| Malignant tumor of colon, Neoplastic disease | Epigenetic Alterations | Because aberrant DNA methylation may contribute to the initiation or progression of colon cancer, we hypothesized that deficient intakes of folate or methionine and high consumption of alcohol, an antagonist of methyl-group metabolism, increase risk of colon neoplasia. | 7707417 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. | 7858479 |
| Carcinoma, Adenoma | Epigenetic Alterations | Intrinsic DNA methylation was significantly lower in carcinomas than in adenomas (P < 0.005). | 7858479 |
| Depressed mood | Epigenetic Alterations | The fact that not all cases with elevated ERBB2 mRNA synthesis were immunohistochemically positive suggests that either immunohistochemistry (after fixation with 10% formalin) is a less sensitive method than in situ hybridization to detect abnormal gene expression or that there are cases in which the oncoprotein synthesis is for some reason depressed, even though there is an increase in gene transcription. | 7910618 |
| Deficit | Epigenetic Alterations | This pattern of cytokine gene transcription may explain functional deficits of TIL. | 8029672 |
| Burn injury, Depressed mood | Epigenetic Alterations | Altered gene transcription after burn injury results in depressed T-lymphocyte activation. | 8092900 |
| Glioma, Glioblastoma Multiforme Pathway | Epigenetic Alterations | In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. | 8645431 |
| Neoplasms | Epigenetic Alterations | The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. | 8645431 |
| Alzheimers Disease | Epigenetic Alterations | This is the first report of an epigenetic defect in an Alzheimers disease patient and the observation suggests that hypomethylation of the APP gene may be one of several factors contributing to aberrant gene expression in Alzheimers disease. | 8746452 |
| Liver carcinoma, Retinoblastoma, Hollings Cancer Center | Epigenetic Alterations | Although genetic changes of Rb gene have been described in hepatocellular carcinoma (HCC), an epigenetic change such as hypermethylation of the Rb promoter as reported in retinoblastoma has not been described. | 8908549 |
| Colorectal Neoplasms | Epigenetic Alterations | DNA hypomethylation and proliferative activity are increased in this group of patients, supporting the concept that their colonic mucosa undergoes epigenetic and kinetic changes that might predispose these individuals to develop colorectal neoplasms. | 8940998 |
| Childhood Leukemia | Epigenetic Alterations | These data (1) provide strong genetic evidence that NF1 functions as a tumor-suppressor in early myelopoiesis, (2) confirm the clonal nature of JCML/JMML, (3) suggest that the elevation in fetal hemoglobin seen in JCML/JMML is a result of primary involvement of erythroid progenitors in the malignant clone, (4) show consistent loss of NF1 in the CD34 cells of affected children and show that the malignant clone may also give rise to pre-B cells in some cases, and (5) implicate epigenetic factors in the development of leukemia in children with NF1. | 8943868 |
| X-linked inheritance | Epigenetic Alterations | Moreover, DNA methylation of X-linked genes in hematopoietic cells may differ from that in other tissues. | 8978285 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Abnormal c-myc oncogene DNA methylation in human bladder cancer: possible role in tumor progression. | 9076471 |
| Breast Carcinoma | Epigenetic Alterations | Our data show that YB-1 has an important role in controlling MDR1 gene transcription and this finding provides a basis for the analysis of molecular mechanisms responsible for intrinsic multidrug resistance in human breast cancer. | 9095180 |
| Human papillomavirus 16 | Epigenetic Alterations | Detection of human papillomavirus type 16 early-gene transcription by reverse transcription-PCR is associated with abnormal cervical cytology. | 9163482 |
| Malignant tumor of colon | Epigenetic Alterations | Are dietary factors involved in DNA methylation associated with colon cancer? | 9200151 |
| Carcinogenesis | Epigenetic Alterations | Disturbances in DNA methylation have been hypothesized as being involved in carcinogenesis. | 9200151 |
| Malignant tumor of colon | Epigenetic Alterations | It has been proposed that dietary factors such as folate, alcohol, and methionine may be associated with colon cancer because of their involvement in DNA methylation processes. | 9200151 |
| Malignant tumor of colon | Epigenetic Alterations | Findings from this study provide only limited support for previously reported associations between dietary factors involved in DNA methylation and risk of colon cancer. | 9200151 |
| Infective cervicitis | Epigenetic Alterations | Genomic deletion on 3p and 5p was correlated with genetic or epigenetic p53 inactivation pathways, including p53 mutation, genetic deletion of p53 and cervical infection with human papillomavirus. | 9219832 |
| Neoplasms | Epigenetic Alterations | Although not all tumors were hypermethylated, these observations are consistent with an important role for epigenetic mechanisms in human cancer. | 9269993 |
| HRAS wt Allele, Carcinogenesis | Epigenetic Alterations | Alterations of level of total genomic DNA methylation and pattern of c-myc, c-Ha-ras oncogene methylation in human gastric carcinogenesis. | 9275356 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | We previously reported that the abl promoter (Pa) undergoes de novo DNA methylation in the course of chronic myelocytic leukemia (CML). | 9389709 |
| Neoplasms | Epigenetic Alterations | Aberrant DNA methylation has been observed consistently in many human tumours, in particular in the CpG islands of tumour suppressor genes, but the underlying mechanism of these changes remains unclear. | 9529124 |
| Prostate Cancer Pathway | Epigenetic Alterations | These results indicate that mutations in p16 may not be a dominant pathway for p16 loss of function or that inactivation of p16 by DNA methylation may not be necessary for the transformation and progression of prostate cancer. | 9537647 |
| Primary central nervous system lymphoma | Epigenetic Alterations | In summary, inactivation of CDKN2A by either homozygous deletion or DNA methylation represents an important molecular mechanism in PCNSL. | 9546285 |
| Peripheral T-Cell Lymphoma | Epigenetic Alterations | Amplification of the TCL1 flanking region at 14q32.1 with no TCL1 gene transcription in a patient with peripheral T cell lymphoma. | 9639427 |
| Neuroblastoma | Epigenetic Alterations | Strong NF-kappaB-DNA binding has been reported previously to temporally precede COX-2 gene transcription in human epithelial (A549), hamster B-cell (HIT-T15), human endothelial (HUVEC), human lymphoblast (IM9), human fibroblast (IMR90), rat glioma/mouse neuroblastoma (NG108-15), human keratinocyte (NHEK), mouse fibroblast (NIH 3T3), rat neuroblastoma (SH-SY5Y) cell lines and in mouse and rat brain hippocampus, indicating a highly conserved inflammatory signaling pathway that is common to diverse species and cell types. | 9726429 |
| Discordance, "Sotos syndrome | Epigenetic Alterations | Our finding of discordance in these identical twins suggests that a postconceptual mutation, or epigenetic change and/or an environmental factor may be involved in the cause of Sotos syndrome. | 9781916 |
| Liver carcinoma | Epigenetic Alterations | Correlation between DNA methylation and pathological changes in human hepatocellular carcinoma. | 9840141 |
| Hollings Cancer Center | Epigenetic Alterations | In addition, we measured the level of global DNA methylation in cancerous and paracancerous tissues of HCC by incubating DNA with 3H-S-adenosylmethionine (3H-SAM) in the presence of methylase. | 9840141 |
| Liver carcinoma | Epigenetic Alterations | The results showed that the hypomethylation rates of c-myc and c-N-ras oncogenes were 30% and 61% respectively in human hepatocellular carcinoma, coinciding with a decreased level of global DNA methylation. | 9840141 |
| Hepatocarcinogenesis | Epigenetic Alterations | It is concluded that abnormal DNA methylation plays an important role in the process of hepatocellular carcinogenesis. | 9840141 |
| Malignant neoplasm of liver | Epigenetic Alterations | DNA methylation level is closely correlated with the biological characteristic of liver cancer, the lower the level of DNA methylation, the stronger the infiltration and metastatic capacity. | 9840141 |
| Colorectal, Primary malignant neoplasm | Epigenetic Alterations | Aging and DNA methylation in colorectal mucosa and cancer. | 9850084 |
| Colorectal Cancer Pathway, Multiple Endocrine Neoplasia, Neoplasms | Epigenetic Alterations | DNA methylation of promoter-associated CpG islands may function as an alternate mechanism of silencing tumor suppressor genes in multiple neoplasias including colorectal cancer. | 9850084 |
| TSPYL2 wt Allele | Epigenetic Alterations | Because c-Myc/Max heterodimers are strong gene transcription activators and are necessary for cell-cycle progression, they may play a role in the progression of CTCL. | 9864169 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | The predominance of G:C-->A:T transitions at CpG sites, which are associated with methyltransferase-induced DNA methylation at carbon 5 of cytosine, in all three tumor types suggests that the status of DNA methylation may be the major determinant for p53 mutations and may be also equally important in gastric carcinogenesis regardless of histology. | 9886570 |
| Liver neoplasms | Epigenetic Alterations | These results suggest that circulating liver tumor DNA may be detected using tumor-associated DNA methylation changes. | 9892188 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | We examined a total of 34 tumours from 30 hepatocellular carcinoma (HCC) patients for deletion, mutation and DNA methylation of these two genes by polymerase chain reaction (PCR) amplification, sequence analysis and Southern blot. | 9893670 |
| Liver carcinoma | Epigenetic Alterations | High levels of DNA methylation were detected in 24 of 29 cases of hepatocellular carcinoma with negative p16(INK4) expression, with methylation of 60%-85% of the CpG islands. | 9922321 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | A strong correlation was found between the extent of methylation and the degree of expression of p16(INK4) in tumor tissues, indicating that epigenetic change due to extensive CpG methylation is the main cause of inactivation of p16(INK4) in hepatocellular carcinoma. | 9922321 |
| Breast Carcinoma | Epigenetic Alterations | Interestingly, most cases with MI at the region encoding for p16 were aggregated in a subgroup of breast carcinomas with no other obvious genetic and/or epigenetic CDKN2/p16(INK4A) alterations. | 9990866 |
| Hepatocarcinogenesis, HCCS gene, Neoplasms, Liver carcinoma | Epigenetic Alterations | To examine the significance of aberrant DNA methylation in hepatocarcinogenesis, the DNA methylation status at the D17S5 locus and mRNA expression of a candidate tumor suppressor gene, HIC-1 (hypermethylated-in-cancer), which was identified at the D17S5 locus, in primary hepatocellular carcinomas (HCCs) and their corresponding noncancerous liver tissues were assessed. | 10051471 |
| Hepatocarcinogenesis | Epigenetic Alterations | These data suggest that aberrant DNA methylation at this locus and reduced HIC-1 mRNA expression participate in hepatocarcinogenesis during both early developmental stages and malignant progression of HCCs. | 10051471 |
| Neoplasms | Epigenetic Alterations | Alterations in DNA methylation in tumours have been reported and have been used to generate hypotheses about mutagenesis and silencing of tumour suppressor genes. | 10071236 |
| Colonic adenomas | Epigenetic Alterations | Effect of folate supplementation on DNA methylation of rectal mucosa in patients with colonic adenomas: correlation with nutrient intake. | 10205316 |
| Cystadenocarcinoma | Epigenetic Alterations | This indicates that cystadenocarcinomas have a mixed biological phenotype and suggests they could arise either from pluripotent cells or from neoplastic cells that reacquire epigenetic features. | 10207666 |
| melanoma | Epigenetic Alterations | Heterogeneity of HLA-G gene transcription and protein expression in malignant melanoma biopsies. | 10213506 |
| melanoma | Epigenetic Alterations | This work provides evidence that HLA-G gene transcription and protein expression can be up-regulated ex vivo in melanoma. | 10213506 |
| Adenocarcinoma of prostate | Epigenetic Alterations | High frequency of alterations in DNA methylation in adenocarcinoma of the prostate. | 10334105 |
| Small cell carcinoma of lung, Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | The p16INK4A tumor suppressor gene is frequently inactivated in non-small cell lung carcinoma (NSCLC) and is less frequently inactivated in small cell lung carcinoma (SCLC) by mutation, deletion or DNA methylation. | 10339660 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Our results suggest that deregulation of DNA methyltransferase gene expression does not play a role in establishing tumor-specific abnormal DNA methylation patterns in human colorectal cancer. | 10344733 |
| Primary malignant neoplasm | Epigenetic Alterations | Abnormal DNA methylation has been found to be a common feature in cancer cells, although the mechanism of this alteration remains poorly understood. | 10360376 |
| Transitional cell carcinoma of kidney | Epigenetic Alterations | DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas. | 10424731 |
| Neoplasms | Epigenetic Alterations | Since DNA methylation is considered an important mechanism for silencing of retroelements in the mammalian genome, hypomethylation in human tumours may lead to their reactivation. | 10424731 |
| Transitional cell carcinoma of ureter | Epigenetic Alterations | The coordinate changes of LINE-1 and HERV-K DNA methylation suggest that hypomethylation in urothelial cancer affects a variety of different retroelements to similar extents. | 10424731 |
| Acquired Immunodeficiency Syndrome | Epigenetic Alterations | In addition to the effect of HIV-1 induced immune suppression, HIV may act directly as a co-factor for stimulation of JCV replication in AIDS patients, in part due to Tat-induced activation of JCV gene transcription. | 10602409 |
| Pancreatic Neoplasm, Ductal Carcinoma | Epigenetic Alterations | These findings suggested that increased expression of sialyl Lewis antigens are involved in pancreatic tumorigenesis and that the accumulation of genetic alterations or epigenetic changes is responsible for the molecular mechanisms of increased expression of the sLe(a) and sLe(x) antigens in ductal carcinomas of pancreas. | 10606190 |
| Hepatitis, Liver Cirrhosis | Epigenetic Alterations | Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis. | 10680595 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | The DNA methylation status of the region around the promoter of the E-cadherin tumor suppressor gene, which is located on 16q22.1, and the allelic status at the D16S421 locus, which is adjacent to the E-cadherin locus, were examined using microdissected liver specimens from 38 hepatocellular carcinoma (HCC) patients. | 10680595 |
| Hepatocarcinogenesis | Epigenetic Alterations | These data suggest that aberrant DNA methylation participates in the precancerous stage of hepatocarcinogenesis by preceding, or causing, LOH. | 10680595 |
| Malignant Neoplasms, Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | We report here that the pathogenesis of hepatocellular carcinoma (HCC), one of the most common cancers in the world, frequently involves an accumulation of somatic DNA methylation changes at GSTP1, the gene encoding the pi-class glutathione S-transferase. | 10717233 |
| Neoplasms | Epigenetic Alterations | The development of this technique should considerably enhance our ability to rapidly and accurately generate epigenetic profiles of tumor samples. | 10734209 |
| Meningioma, Neoplasms | Epigenetic Alterations | Despite the high frequency of LOH at 1p32 microsatellite markers, the lack of genetic and epigenetic aberrations in the p18 gene together with the presence of p18 protein in all but one meningioma samples argues against the role of p18 as a tumour suppressor gene important for meningioma development. | 10736068 |
| Adenoma of large intestine | Epigenetic Alterations | 5,10-Methylene-tetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, may play a role in the etiology of colorectal adenomas via effects on DNA methylation and nucleotide synthesis. | 10744125 |
| SF3B1 wt Allele | Epigenetic Alterations | An unanswered question is whether p15INK4B gene methylation is restricted to undifferentiated blastic cells, or whether differentiated cells such as granulocytes or erythrocytes of MDS origin also harbor this epigenetic alteration. | 10764143 |
| Breast Carcinoma | Epigenetic Alterations | CpG island arrays: an application toward deciphering epigenetic signatures of breast cancer. | 10778974 |
| Primary malignant neoplasm | Epigenetic Alterations | CpG island hypermethylation is a frequent epigenetic event in cancer. | 10778974 |
| Clinical Coordinator, High-Frequency Microsatellite Instability, Hereditary Nonpolyposis Colorectal Cancer, DNA Mismatch Repair Protein MSH2, human | Epigenetic Alterations | The MSI-H phenotype, observed in both hereditary nonpolyposis colon cancer-associated CRC and approximately 15% of sporadic CRC, generally results from mutational or epigenetic inactivation of the DNA mismatch repair (MMR) genes hMSH2 or hMLH1. | 10786688 |
| Colorectal Neoplasms | Epigenetic Alterations | The enzyme 5,10-methylene-tetrahydrofolate reductase (MTHFR) may be linked to DNA methylation and nucleotide synthesis and thus play a role in the etiology of colorectal neoplasia. | 10794488 |
| Admitting diagnosis | Epigenetic Alterations | These data establish that the association of Ckidelta with the tau pathology of AD is reflective of an increase in gene transcription. | 10814741 |
| IGA Glomerulonephritis | Epigenetic Alterations | Adrenomedullin gene transcription is decreased in peripheral blood mononuclear cells of patients with IgA nephropathy. | 10867534 |
| Neoplasms | Epigenetic Alterations | However, the frequency of genetic and epigenetic inactivation of LKB1/STK11 in sporadic tumours is unclear. | 10896921 |
| Squamous cell carcinoma | Epigenetic Alterations | The accumulation of ascorbic acid by squamous cell carcinomas of the lung and larynx is associated with global methylation of DNA. | 10897014 |
| Metastasis, Liver carcinoma, Infiltration | Epigenetic Alterations | The decrease of DNA methylation is present at the stage of liver carcinoma, and hypomethylation of c-myc, c-N-ras genes is correlated with the tendency of infiltration and metastasis. | 10920889 |
| Malignant neoplasm of urinary bladder, Carcinoma of bladder, Carcinoma, Transitional Cell | Epigenetic Alterations | To identify targets of genetic and epigenetic alterations on chromosome 11p15.5 in human bladder cancer, expression of the imprinted KIP2, IGF2 and H19 genes was studied by quantitative RT-PCR in 24 paired samples of urothelial carcinomas and morphologically normal mucosa obtained by cystectomy, and in bladder carcinoma cell lines. | 10944603 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The KIP2 gene could be an important target of genetic and epigenetic alterations in bladder cancer affecting the maternal chromosome 11p15.5. | 10944603 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Genetic and epigenetic alterations in normal bladder epithelium in patients with metachronous bladder cancer. | 10945601 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | To see whether normal mucosa had already acquired genetic or epigenetic changes, we examined loss of heterozygosity (LOH) at 10 microsatellite loci and methylation of the p16(INK4) CpG island in multiple tumors and pathologically normal mucosa in six patients with bladder cancer. | 10945601 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | This result indicated that a population of cells in morphologically normal epithelium possessed genetic or epigenetic aberrations in common with bladder cancer, which might provide a ground for multiple tumorigenesis. | 10945601 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is an epigenetic feature of DNA that influences cellular development and function, and aberrations of DNA methylation are a candidate mechanism for the development of cancer. | 10952104 |
| Primary malignant neoplasm | Epigenetic Alterations | The nuclear matrix-intermediate filament complex (NM-IF) is a protein scaffold which spans the whole cell, and several lines of evidence suggest that this structural frame represents also a functional unit, which could be involved in the epigenetic control of cancer development. | 10972984 |
| Carcinogenesis | Epigenetic Alterations | Previous data support the hypothesis that abnormal DNA methylation plays an integral role in carcinogenesis. | 11010943 |
| Malignant Neoplasms | Epigenetic Alterations | We have previously shown malignancy is associated with increased DNA methylation in the 5 region of the PTHrP gene. | 11044652 |
| Primary malignant neoplasm | Epigenetic Alterations | Although demethylation may be a prerequisite for P2 and P3 expression, the overexpression of the PTHrP gene in cancer cells must be mediated through mechanisms other than DNA methylation. | 11044652 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | DNA methylation and the mechanisms of CDKN2A inactivation in transitional cell carcinoma of the urinary bladder. | 11045568 |
| Hepatitis, Liver Cirrhosis, Liver carcinoma | Epigenetic Alterations | Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. | 11050047 |
| Hepatocarcinogenesis, Loss of Heterozygosity | Epigenetic Alterations | The results of this study indicate that LOH and aberrant DNA methylation contribute to hepatocarcinogenesis; DNA hypermethylation in particular, which precedes or may even cause LOH, is as an early event during hepatocarcinogenesis. | 11050047 |
| Prostate carcinoma | Epigenetic Alterations | Alterations of DNA methylation are very frequent in prostatic carcinoma. | 11074524 |
| Uterine Cancer | Epigenetic Alterations | Additionally, there was no low DNA methylation in ER negative uterine cancer tissues. | 11083005 |
| Prostate Cancer Pathway | Epigenetic Alterations | Because this epigenetic DNA alteration can be reliably detected by methylation-specific PCR (MSP), we applied this new technique for molecular detection of prostate cancer in various human bodily fluids. | 11085508 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic down-regulation of DAP-Kinase gene expression by hypermethylation of its promoter region was reported in B-cell malignancies. | 11092525 |
| Colorectal Carcinoma, "cytidylyl-3-5-guanosine | Epigenetic Alterations | DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. | 11146446 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Alterations in DNA methylation have been associated with cancers at almost all tumor sites and represent one of the most consistent changes in neoplastic cells. | 11205492 |
| Lymphoma | Epigenetic Alterations | Taken together, an increased susceptibility for TNF gene transcription after LPS stimulation was observed in PBC (mainly in monocytes) from lymphoma patients, and especially those carrying the TNF2 allele. | 11274761 |
| Prostate Cancer Pathway | Epigenetic Alterations | Epigenetic regulation of human bone morphogenetic protein 6 gene expression in prostate cancer. | 11277266 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Our results suggested that during cancer progression, besides inactivation of tumor suppressor genes by hypermethylation, activation of certain genes like BMP-6 by selective demethylation was a common epigenetic event giving a variable character to the invading and metastasizing cancer cells. | 11277266 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In a consecutive series of early stage non-small cell lung cancer (NSCLC), we have established the loss of expression of the G1 Cdk inhibitors p15INK4b) and p16INK4a by DNA methylation is very common (37%), and methylation of p16INK4a is tightly correlated with loss of expression of p16INK4a protein (P = 0.0018). | 11282426 |
| Radiation-induced disorder | Epigenetic Alterations | The association might contribute, as an epigenetic and/or bystander effect, to development of several radiation-induced disorders. | 11304439 |
| Anaplastic Oligodendroglioma, oligodendroglioma | Epigenetic Alterations | The locus is deleted in up to 25% of oligodendrogliomas and 50% of anaplastic oligodendrogliomas, but little is known on the frequency of gene silencing by DNA methylation. | 11307615 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | Epigenetic patterns in the progression of esophageal adenocarcinoma. | 11309301 |
| Numerous | Epigenetic Alterations | Each class undergoes unique epigenetic changes at different steps of disease progression of EAC, suggesting a step-wise loss of multiple protective barriers against CpG island hypermethylation. | 11309301 |
| Malignant neoplasm of breast | Epigenetic Alterations | Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. | 11333291 |
| Malignant neoplasm of breast, Neoplasms | Epigenetic Alterations | RASSF1A is a potential tumor suppressor gene that undergoes epigenetic inactivation in lung and breast cancers through hypermethylation of its promoter region. | 11333291 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Heterogeneity of DNA methylation status analyzed by bisulfite-PCR-SSCP and correlation with clinico-pathological characteristics in colorectal cancer. | 11341745 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation has been identified as an important mechanism for inactivation of tumor suppressor genes and mismatch repair genes during carcinogenesis. | 11341745 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | Moreover, the degree of reduced DNA methylation was related to late histopathological HCC grade (P = 0.005) and large tumor size (P = 0.079). | 11358850 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Because immunohistochemical study revealed that all of the ESCC samples showed loss of ING1 protein expression, genetic or epigenetic alterations that abrogate the normal function of ING1 may contribute to esophageal squamous cell carcinogenesis. | 11389058 |
| Malignant Neoplasms | Epigenetic Alterations | Specifically, genome-wide decreased DNA methylation (hypomethylation) in human cancers might be a consequence of decreased SAM levels. | 11406421 |
| Stomach Carcinoma | Epigenetic Alterations | These results suggest that epigenetic changes in the hMLH1 promoter account for the genesis of multiple gastric carcinoma with high frequency MSI. | 11422806 |
| ovarian neoplasm | Epigenetic Alterations | The expression of dMTase is a common feature of ovarian cancer and there is a correlation between dMTase and LRP expression, suggesting that there may be an epigenetic upregulation of the gene. | 11471858 |
| Neoplasms | Epigenetic Alterations | The epigenetic (nonhereditary) mechanism of hMLH1 promoter hypermethylation appears to be responsible for the majority of the remaining patients whose tumors are characterized by defective DNA MMR. | 11524701 |
| ovarian neoplasm | Epigenetic Alterations | DNA methylation and ovarian cancer. | 11531277 |
| ovarian neoplasm | Epigenetic Alterations | Epigenetic signatures in ovarian cancer were determined using DMH. | 11531277 |
| Prostate Cancer Pathway | Epigenetic Alterations | This epigenetic DNA alteration served as the target for molecular detection of prostate cancer cells in urine sediments after prostatic massage. | 11549474 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | These data suggest that epigenetic silencing via aberrant methylation of the E-cadherin promoter is a common cause of inactivation of this gene in esophageal adenocarcinoma. | 11555590 |
| Tumor necrosis | Epigenetic Alterations | Recently, the mouse homologue of the tumor necrosis factor receptor superfamily 6 (TNFRSF6) gene was reported to be inactivated by DNA methylation in various cell types. | 11568974 |
| Carcinoma | Epigenetic Alterations | Thus, although the TNFRSF6 gene can be inactivated efficiently by DNA methylation, hypermethylation occurs neither frequently nor extensively in human carcinomas and appears to play a limited role in downregulation of Fas expression. | 11568974 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic changes, including DNA methylation, are a common finding in cancer. | 11571631 |
| Malignant neoplasm of lung | Epigenetic Alterations | Although the importance of aberrant DNA methylation is well established, the extent of DNA methylation in lung cancers has never been determined. | 11571631 |
| Mismatch Repair Deficiency, Hereditary Nonpolyposis Colorectal Cancer | Epigenetic Alterations | Microsatellite instability is a hallmark of mismatch repair deficiency in hereditary nonpolyposis colorectal cancer and results from mutations in the mismatch repair genes MLH1 or MSH2 or from gene inactivation associated with DNA methylation. | 11601928 |
| Stomach Carcinoma | Epigenetic Alterations | We hypothesized that loss of RARbeta in gastric cancer cells may occur as a result of multiple factors, including epigenetic modifications which alter RARbeta promoter chromatin structure. | 11683489 |
| Nephroblastoma, Imprinting (Psychology) | Epigenetic Alterations | Loss of imprinting (LOI) of the insulin-like growth factor-II (IGF2) gene, an epigenetic alteration associated with expression of the normally silent maternal allele, was observed first in Wilms tumor. | 11717330 |
| Barrett Esophagus, Adenocarcinoma Of Esophagus | Epigenetic Alterations | We conclude that most Barretts metaplasia contains genetic and/or epigenetic p16 lesions and has the ability to undergo clonal expansion, creating a field in which other abnormalities can arise that can lead to esophageal adenocarcinoma. | 11719461 |
| DNA Mismatch Repair Protein MSH2, human, MSH6 protein, human | Epigenetic Alterations | Defective DNA MMR results from genetic or epigenetic alterations that inactivate the DNA MMR genes hMLH1 or hMSH2, and rarely hMSH6. | 11753964 |
| NCI CTEP SDC Oligodendroglial Tumors Sub-Category Terminology | Epigenetic Alterations | Taken together, our results indicate that hypermethylation of CDKN2A, p14ARF, and CDKN2B is an important epigenetic mechanism by which oligodendroglial tumors may escape from p53- and pRb-dependent growth control. | 11764089 |
| Malignant Neoplasms | Epigenetic Alterations | We attempted to identify tumor-related genes whose expression is affected by DNA methylation and that participate in the determination of the biological characteristics of human cancers. | 11768609 |
| Carcinogenesis | Epigenetic Alterations | Recent data suggest that such epigenetic abnormality may occur very early in lung carcinogenesis. | 11809677 |
| Adenomatous Polyposis Coli, Primary Neoplasm, Carcinoma of lung, Gastrointestinal Neoplasms | Epigenetic Alterations | Because genetic and epigenetic alterations of the adenomatous polyposis coli (APC) gene are common events in gastrointestinal tumor development, we sought to investigate the frequency and level of aberrant APC promoter methylation in primary tumors and paired preoperative serum or plasma samples of lung cancer patients by semiquantitative methylation-specific fluorogenic real-time PCR. | 11809682 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | To elucidate the impact of this epigenetic mechanism on telomerase activity, we analyzed the degree of hTERT promoter methylation in 30 patients with B-cell chronic lymphocytic leukemia. | 11823034 |
| Hepatocarcinogenesis, Hollings Cancer Center | Epigenetic Alterations | This is a new type of predictive factor for HCC based on epigenetic changes in hepatocarcinogenesis, and in the future it is expected to be of great value in making preoperative diagnosis and selecting postoperative therapy. | 11850807 |
| Adenocarcinoma of prostate, Neoplasms | Epigenetic Alterations | Epigenetic DNA alterations such as promoter hypermethylation of glutathione S-transferase P1 (GSTP1) in prostatic adenocarcinoma frequently constitute tumour biomarkers. | 11857497 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | A polymorphic variant (TT) has been linked to reduced levels of plasma folate, aberrant DNA methylation in leucocytes, and increased risk of colorectal cancer (CRC) under conditions of low folate intake. | 11889073 |
| Clinical Coordinator | Epigenetic Alterations | These variants may be involved in the development of the subgroup of CRC displaying aberrant DNA methylation and frequently associated with microsatellite instability (MSI). | 11889073 |
| Oral Cavity Carcinoma | Epigenetic Alterations | Epigenetic inactivation of 14-3-3 sigma in oral carcinoma: association with p16(INK4a) silencing and human papillomavirus negativity. | 11929827 |
| Carcinogenesis | Epigenetic Alterations | These findings indicate that both genetic and epigenetic events occur independently in intratumor foci and further suggest hypermethylation-induced loss of gene function may be as critical as specific genetic mutations in prostate carcinogenesis. | 11943705 |
| Colorectal Neoplasms | Epigenetic Alterations | MSI in sporadic colorectal tumours is primarily due to epigenetic silencing of MLH1. | 11948461 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | The strong association seen between p16 methylation in the bronchial epithelium and corresponding primary tumor substantiates that inactivation of this gene, although not transforming by itself, is likely permissive for the acquisition of additional genetic and epigenetic changes leading to lung cancer. | 11956099 |
| Colorectal Carcinoma, Colorectal Cancer Pathway, AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED | Epigenetic Alterations | Our findings suggest that methylation in ACF is an early event in the pathogenesis of a subset of colorectal carcinomas, and that ACF from FAP patients and patients with sporadic colorectal cancer have distinct epigenetic changes that reflect differences in molecular pathogenesis. | 12000733 |
| Prostate carcinoma | Epigenetic Alterations | Because GSTP1 promoter hypermethylation and inactivation of GSTpi expression is a frequent alteration in prostate carcinoma, we hypothesized that this somatic epigenetic modification could obviate any reduced enzyme activity caused by the germ-line polymorphism. | 12010858 |
| Adenoma | Epigenetic Alterations | However, menin might be involved in sporadic adenoma tumorigenesis by downregulation through intronic mutations, epigenetic, posttranscriptional or posttranslational mechanisms. | 12030908 |
| Primary malignant neoplasm | Epigenetic Alterations | CpG island methylation is an important mechanism in gene silencing and is a key epigenetic event in cancer development. | 12032849 |
| Neoplasms | Epigenetic Alterations | This study provides an important resource in the search for genes inactivated in tumors and for the investigation of epigenetic dysregulation of gene expression by CpG island methylation. | 12032849 |
| Malignant Neoplasms | Epigenetic Alterations | In general, >60% of serum from cancers with aberrant methylation demonstrated these epigenetic alterations. | 12060614 |
| Acute lymphocytic leukemia | Epigenetic Alterations | DNA methylation patterns at relapse in adult acute lymphocytic leukemia. | 12060634 |
| Acute leukemia | Epigenetic Alterations | Aberrant DNA methylation of promoter-associated CpG islands is an epigenetic DNA modification observed in acute leukemias that in certain cases has been associated with a poor prognosis and increased relapse rates. | 12060634 |
| Acute lymphocytic leukemia | Epigenetic Alterations | To study the role of DNA methylation in relapse mechanisms in acute lymphocytic leukemia (ALL), we have compared the methylation status of five genes at the time of initial presentation and at first relapse in 25 adult patients with ALL. | 12060634 |
| Acute lymphocytic leukemia | Epigenetic Alterations | In summary, DNA methylation patterns are stable in a majority of patients with relapsed ALL, but a subset of patients acquire new methylation changes, in particular affecting cell cycle regulatory genes. | 12060634 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. | 12114441 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | These results indicated that epigenetic inactivation of RASSF1A plays an important role in the progression of lung adenocarcinoma, and that RASSF1A hypermethylation appears to be a useful molecular marker for the prognosis of patients with stage I lung adenocarcinoma. | 12114441 |
| Endometrial Neoplasms | Epigenetic Alterations | In patients with MSI positive EC, epigenetic inactivations rather than genetic mutations of the MMR genes seem to be involved in endometrial tumorigenesis. | 12115348 |
| Endometrial Carcinoma | Epigenetic Alterations | Ribosomal DNA methylation in patients with endometrial carcinoma: an independent prognostic marker. | 12115383 |
| Liver Cirrhosis, Hollings Cancer Center | Epigenetic Alterations | Inactivation by DNA methylation of several genes of the RB1 pathway is common to cirrhosis and HCC. | 12143052 |
| Carcinogenesis | Epigenetic Alterations | This means that a constitutive activation of antiapoptotic molecules via genetic or epigenetic mechanisms, including gene amplification, may well be involved in carcinogenesis. | 12208731 |
| Discordance, Synesthesia | Epigenetic Alterations | We suggest that the discordance in synaesthesia may be due to either an epigenetic event, X chromosome inactivation, or a mutation of a synaesthesia gene. | 12221147 |
| Pulmonary Hypertension, Gaucher Disease, Type 3 (disorder) | Epigenetic Alterations | Pulmonary hypertension in type 1 Gauchers disease: genetic and epigenetic determinants of phenotype and response to therapy. | 12359135 |
| Congenital absence of spleen | Epigenetic Alterations | Progression to severe, life-threatening PH occurs in the presence of additional genetic factors (non-N370S GBA mutation, positive family history, and ACE I gene polymorphism) and epigenetic modifiers (i.e., asplenia and female sex). | 12359135 |
| Primary malignant neoplasm | Epigenetic Alterations | In the cancer patients, no significant changes were found in TNF-RI and TNF-RII gene transcription, compared to the controls. | 12378118 |
| Admitting diagnosis, Depression, CTCAE | Epigenetic Alterations | Compared to controls and 354 background/alignment markers, AD brain showed a generalized depression in brain gene transcription, including decreases in RNA encoding transcription factors (TFs), neurotrophic factors, signaling elements involved in synaptic plasticity such as synaptophysin, metallothionein III, and metal regulatory factor-1. | 12391607 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Frequent epigenetic silencing of the p16 gene in non-small cell lung cancers of tobacco smokers. | 12417040 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These findings suggest that tobacco smoking leads to inactivation of the p16 gene mainly through the epigenetic mechanism, ultimately increasing the risk of NSCLC, especially the squamous cell histological type. | 12417040 |
| Hollings Cancer Center | Epigenetic Alterations | Furthermore, co-existence of methylated with unmethylated DNA in some cases suggested that both genetic and epigenetic (CpG methylation) mechanisms may act in concert to inactivate the p16INK4a and RASSF1a in HCC. | 12433278 |
| Carcinogenesis | Epigenetic Alterations | Methylenetetrahydrofolate reductase (MTHFR) plays a centralrole in converting folate to methyl donor for DNA methylation, an epigenetic modification known to be dysregulated in carcinogenesis. | 12433726 |
| LINC01191 gene | Epigenetic Alterations | Epigenetic silencing of p16(INK4a) was detected in 68% of VC, 69.2% of VIN, and 42.8% of LS cases. | 12454817 |
| Carcinoma, S100A4 protein, human, LINC01191 gene | Epigenetic Alterations | We conclude (1) that p16(INK4a) epigenetic inactivation most likely represents an early event, insufficient for malignant transformation, that may occur in clinically benign lesions such as LS; (2) that lack of pRb was only detected in fewer than one quarter of the carcinomas and could be considered a late secondary event; and (3) that cyclin-D1, which was overexpressed in VC and VIN, could contribute to the malignant transformation in association with p16 hypermethylation. | 12454817 |
| Lung Neoplasms | Epigenetic Alterations | DNA methylation profiles of lung tumors. | 12467239 |
| Neoplasms | Epigenetic Alterations | Thus, tumor cell lines appear to be suitable models to study aberrant DNA methylation. | 12467239 |
| Prostate Cancer Pathway | Epigenetic Alterations | In prostate cancer, GSTP1 hypermethylation is the most common epigenetic alteration, and can be detected in up to 90% of cases. | 12499435 |
| Non-Metastatic Carcinoma | Epigenetic Alterations | Biallelic inactivation of hMLH1 by epigenetic silencing existed in human primary gastric carcinoma homogeneously. | 12508345 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation, an epigenetic modification, can result in loss of gene function in cancer, similar to genetic mutations such as deletions and point mutations. | 12525538 |
| Primary Neoplasm, Neoplasms | Epigenetic Alterations | We discuss two possible explanations for how different epigenetic events might arise between the primary tumour and the metastatic tumour of a person. | 12525538 |
| Malignant Neoplasms | Epigenetic Alterations | These results suggest that epigenetic inactivation of Chfr may be responsible for many of the checkpoint defects observed in human cancers. | 12538348 |
| Aggressive behavior, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | This epigenetic alteration is associated with inferior survival, suggesting that MGMT promoter hypermethylation might be an important biomarker for a biological aggressive disease in NSCLC. | 12538473 |
| Alcoholic Liver Diseases | Epigenetic Alterations | Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease. | 12540792 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia. | 12548613 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Aberrant methylation of promoter-associated cystosine-guanine (CpG) islands is an epigenetic modification of DNA frequently observed in adult patients with acute lymphocytic leukemia (ALL). | 12548613 |
| S100A4 protein, human | Epigenetic Alterations | This epigenetic modification has been associated with gene silencing, malignant transformation, and aging. | 12548613 |
| Acute lymphocytic leukemia | Epigenetic Alterations | It is not known whether there are epigenetic differences between pediatric patients and adult patients with ALL. | 12548613 |
| Primary malignant neoplasm | Epigenetic Alterations | It thus appears loss of allelic coordination is an epigenetic alteration characterizing cancer, which is easily identified by simple cytogenetic means and has a potential use in both cancer investigation and detection. | 12550768 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. | 12586619 |
| Acute lymphocytic leukemia | Epigenetic Alterations | DNA methylation of a region surrounding the transcription start site of p57KIP2 was found in acute lymphocytic leukemia (ALL)-derived cell lines. | 12586619 |
| Rectal Carcinoma | Epigenetic Alterations | Findings provide limited support for an association between dietary factors involved in DNA methylation and risk of cancers of the colon and rectum. | 12588695 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | This epigenetic inactivation mechanism remains elusive in hepatocellular carcinoma (HCC). | 12592365 |
| Neoplasms | Epigenetic Alterations | These data suggested that MGMT gene silencing in a subset of HCCs was likely caused by epigenetic alteration, such as promoter hypermethylation, and that the promoter hypermethylation silenced the hMLH1 gene in half of the hMLH1-negative tumours. | 12592365 |
| Malignant Neoplasms, Carcinoma, Transitional Cell | Epigenetic Alterations | In many common cancers such as transitional cell carcinoma (TCC), specific genes are hypermethylated, whereas overall DNA methylation is diminished. | 12594811 |
| Suicidal behavior | Epigenetic Alterations | Given the significance of CREB in mediating various physiological functions through gene transcription, our results of decreased expression and functional characteristics of CREB in postmortem brain of suicide subjects suggest that CREB may play an important role in suicidal behavior. | 12622660 |
| Paroxysmal nocturnal hemoglobinuria, Aplastic Anemia | Epigenetic Alterations | This epigenetic change is an additional feature shared by PNH and aplastic anemia. | 12623835 |
| Traditional Serrated Adenoma | Epigenetic Alterations | K-ras mutations in serrated adenomas may be unaffected by the epigenetic silencing of O6-methylguanine-DNA methyltransferase by promoter hypermethylation. | 12626907 |
| Malignant Neoplasms | Epigenetic Alterations | Alteration of DNA methylation is one of the most consistent epigenetic changes in human cancers. | 12637155 |
| Clinical Coordinator, Colorectal Cancer Pathway, Imprinting (Psychology) | Epigenetic Alterations | Loss of imprinting (LOI), an epigenetic alteration affecting the insulin-like growth factor II gene (IGF2), is found in normal colonic mucosa of about 30% of colorectal cancer (CRC) patients, but it is found in only 10% of healthy individuals. | 12637750 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | We performed a genetic and epigenetic study of the hMLH1 and hMSH2 mismatch repair genes in resected primary tumors from 77 non-small cell lung cancer (NSCLC) patients. | 12639995 |
| Carcinogenesis | Epigenetic Alterations | Folate metabolism is thought to play an important role in carcinogenesis through its involvement in both DNA methylation and nucleotide synthesis. | 12649184 |
| Colorectal Neoplasms | Epigenetic Alterations | These epigenetic changes were assessed in colorectal neoplasia to determine whether they arose through a common mechanism or indeed were distinct and unrelated phenomena. | 12651628 |
| Primary central nervous system lymphoma, Neoplasms | Epigenetic Alterations | These findings concur with previous data suggesting a frequent inactivation of p16(INK4A) and very limited involvement of TP53 in PCNSL and also provide insights into the epigenetic molecular involvement of other tumor-related genes in this neoplasm. | 12660028 |
| Colorectal Carcinoma, Adenoma | Epigenetic Alterations | Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma. | 12673484 |
| Adenoma of large intestine, Colorectal Cancer Pathway | Epigenetic Alterations | Genetic and epigenetic events encompassing APC occur variously among patients and tissues in sporadic colorectal cancer patients with synchronous colorectal adenoma. | 12673484 |
| Adenomatous Polyposis Coli, Antigen-Presenting Cells, Carcinoma of lung, Primary Neoplasm | Epigenetic Alterations | We tested five gene promoters [CDKN2A (p16), O(6)-methylguanine-DNA-methyltransferase, glutathione S-transferase P1 (GSTP1), adenomatous polyposis coli (APC), and death-associated protein kinase (DAPK)] by real-time methylation-specific PCR in primary tumors from 90 stage I lung cancer patients for aberrant DNA methylation. | 12684406 |
| Primary malignant neoplasm | Epigenetic Alterations | Promoter hypermethylation is an important pathway for repression of gene transcription in cancer cells and a promising marker for cancer detection. | 12684406 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Our findings suggest that epigenetic silencing of RASSF1A gene expression by promoter hypermethylation could play an important role in primary esophageal squamous cell carcinogenesis. | 12684417 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer. | 12684640 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Epigenetic events such as promoter-region gene hypermethylation may be influenced by environmental exposures and have been implicated in prostate carcinogenesis (by the silencing of tumor suppressors and other regulatory genes). | 12692786 |
| Carcinogenesis | Epigenetic Alterations | These results suggest that inactivation of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 by epigenetic silencing does not seem to play a role in gastric carcinogenesis. | 12692836 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | [Estimation of DNA methylation level in endometrial cancer tissues]. | 12722383 |
| Hyperplasia | Epigenetic Alterations | There was no difference between DNA methylation level between normal endometrium and hyperplastic changes. | 12722383 |
| Primary malignant neoplasm | Epigenetic Alterations | The field of epigenetics has seen a recent surge of interest among cancer researchers since alterations in DNA methylation have emerged as one of the most consistent molecular alterations in multiple neoplasms. | 12724234 |
| Primary malignant neoplasm | Epigenetic Alterations | Early detection and risk assessment: proceedings and recommendations from the Workshop on Epigenetics in Cancer Prevention. | 12724234 |
| Primary malignant neoplasm | Epigenetic Alterations | In the workshop the following areas of research were recognized for emphasis in future work: (1) basic epigenetic mechanisms in cancer need further investigation; (2) technology development in the area of epigenetics, such as high-throughput quantitative assays and increased sensitivity/specificity, is essential for the early detection and risk assessment of cancer; (3) the clinical application of epigenetic changes to cancer prevention and risk assessment needs further investigation. | 12724234 |
| Primary malignant neoplasm | Epigenetic Alterations | An important distinction between genetic and epigenetic alterations in cancer prevention is that the latter might be more easily reversed using therapeutic interventions. | 12724234 |
| Carcinoma of ampulla of Vater, Duodenal Cancer | Epigenetic Alterations | Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas. | 12730870 |
| Neoplasms | Epigenetic Alterations | The samples of primary tumor and paired lymph node metastatic tumor were collected and examined for aberrant gene promoter methylation in E-cadherin by DNA Methylation-specific polymerase chain reaction (MSP). | 12760799 |
| Hyperhomocysteinemia | Epigenetic Alterations | Folate therapy, a common method to reduce hyperhomocysteinaemia, restored DNA methylation to normal levels and corrected the patterns of gene expression. | 12767735 |
| Hyperhomocysteinemia | Epigenetic Alterations | Our results suggest that hyperhomocysteinaemia affects epigenetic control of gene expression, which can be reverted by folate treatment. | 12767735 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Epigenetic silencing of RASSF1A is a frequent event in non-small lung cancer and will provide novel opportunities to develop diagnosis and therapy of NSCLC. | 12794755 |
| Mammary Neoplasms, Neoplasms | Epigenetic Alterations | We examined the DNA methylation status of the TMS1 promoter in lung and breast tumor tissues, tumor cell lines and nonmalignant tissues by methylation-specific polymerase chain reaction (MSP) and its mRNA expression by reverse transcription PCR. | 12800194 |
| Malignant Neoplasms, Adenoma | Epigenetic Alterations | Up-regulation of ALP56 gene transcription was observed in both adenomas and cancers compared to normal mucosa. | 12802606 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation. | 12810640 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | These results indicate that SEMA3B gene alterations may play a important role in the malignant transformation of NSCLC via a two-hit mechanism, including epigenetic changes and allelic loss, for tumor suppressor gene inactivation. | 12810670 |
| Prostate Cancer Pathway | Epigenetic Alterations | We have demonstrated the feasibility of a novel, noninvasive molecular approach for the detection of epigenetic changes associated with prostate cancer. | 12855646 |
| Prostate Cancer Pathway | Epigenetic Alterations | Treatment of prostate cancer cell lines with 5-aza-2-deoxycytidine (5-Aza-CdR), an inhibitor of DNA methylation, restored ZNF185 expression levels. | 12873976 |
| Malignant Neoplasms, Myeloid Leukemia, Chronic, Neoplasms | Epigenetic Alterations | General and site-specific DNA methylation is associated with tumor progression and resistance in several cancers, including chronic myelogenous leukemia (CML). | 12879469 |
| SDHD wt Allele | Epigenetic Alterations | These results suggest that the t(6;14) may represent a rare event in the pathogenesis of PGL and that cyclin D3 deregulation is most likely the result of epigenetic mechanisms. | 12898595 |
| Neoplasms | Epigenetic Alterations | DNA methylation of some genes individually showed only trends toward diminished survival, whereas patients whose tumors had >50% of their gene profile methylated had both significantly poorer survival (P = 0.04) and earlier tumor recurrence (P = 0.05) than those without positive methylation. | 12912936 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | We analysed 64 primary lung carcinomas for promoter methylation of the tumour suppressor genes (TSGs) p16 (p16(INK4a)/CDKN2A) and p14 (p14(ARF)) by methylation-specific PCR, in order to evaluate aberrant methylation as a potential biomarker for epigenetic alterations in tobacco-related lung cancer. | 12918069 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | Epigenetic silencing of the p16 and p15 genes by promoter methylation are commonly observed in human epithelial malignancies, including head and neck squamous cell carcinomas (HNSCC). | 12932666 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Recent studies suggest that tumor suppressor genes (TSGs) can also be silenced through epigenetic disruption, such as promoter CpG island methylation, during carcinogenesis. | 12937151 |
| Malignant tumor of colon | Epigenetic Alterations | Genetics supersedes epigenetics in colon cancer phenotype. | 12957287 |
| Primary malignant neoplasm | Epigenetic Alterations | Correlation between protein expression and epigenetic and mutation changes of Wnt pathway-related genes in oral cancer. | 12963979 |
| Malignant neoplasm of mouth | Epigenetic Alterations | In this study, we analyzed the epigenetic changes and expression patterns of four member proteins of the Wnt-signaling pathway and analyzed the mutations of beta-catenin and AXIN 1 genes, in order to explore the roles of the pathway in the development of oral cancer. | 12963979 |
| Carcinoma of larynx | Epigenetic Alterations | We pose that RXRalpha overexpression might represent an early protective effect in the process of laryngeal carcinogenesis that might be overwhelmed by an epigenetic disability in forming heterodimers with PPARgamma. | 12969790 |
| Pancreatic carcinoma, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Our results indicate that maspin expression is up-regulated in most if not all pancreatic ductal adenocarcinomas and may be related to the development and differentiation, and that DNA methylation and histone deacetylation may suppress maspin gene activation in pancreatic cancer cells. | 12969792 |
| Thyroid carcinoma | Epigenetic Alterations | These findings suggest that the infrequent development of thyroid carcinoma in MAS patients involves additional mutational or epigenetic events. | 12970318 |
| Acute lymphocytic leukemia | Epigenetic Alterations | The most common epigenetic lesion in childhood ALL was methylation of E-cadherin (72%) independent of the molecular subtype or other clinicopathological factors. | 12970785 |
| Primary Neoplasm | Epigenetic Alterations | Genetic and epigenetic alterations in sentinel lymph nodes metastatic lesions compared to their corresponding primary breast tumors. | 14499694 |
| Neoplasms | Epigenetic Alterations | The accumulation of genetic and epigenetic changes plays a pivotal role in tumor development and progression. | 14499694 |
| Acute leukemia | Epigenetic Alterations | Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias. | 14513284 |
| Breast Carcinoma | Epigenetic Alterations | p16 and/or CDH1 hypermethylation was found in 31% (11/36) of primary breast carcinomas and 82% (9/11) of breast cancer patients with tumoral methylation showing identical epigenetic changes in plasma. | 14534701 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation is an important biologic event in colorectal cancer and in some cases is associated with the development of microsatellite instability (MSI). | 14551292 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | DNA methylation is associated with a worse outcome in colorectal cancer, but this adverse prognostic influence is lost in those methylated tumors showing MSI. | 14551292 |
| DU-PAN-2 | Epigenetic Alterations | Additionally, there was a good correlation between BETA;3GAL-T5 gene transcription levels and immunohistochemical grades of CA 19-9 or its precursor DUPAN-2 in cancerous tissues. | 14555842 |
| Malignant neoplasm of prostate | Epigenetic Alterations | We investigated the epigenetic silencing of Cyclin D2 gene in prostate cancers and correlated the data with clinicopathological features. | 14581343 |
| Neoplasms | Epigenetic Alterations | Although considerable work has been done on the epigenetic control of tumor suppressor genes, little is known about the potential role of promoter CpG demethylation in the activation of oncogenes. | 14612939 |
| Neoplasms | Epigenetic Alterations | For some tumour suppressor genes, epigenetic silencing is a more common mechanism of inactivation than somatic mutations. | 14627671 |
| Clinical Coordinator, Refractory Cytopenia of Childhood, carmustine/dacarbazine/hydroxyurea | Epigenetic Alterations | However, we did not detect evidence of epigenetic silencing of BHD in 19 CRC and RCC cell lines, and BHD promoter region hypermethylation was not detected in 20 primary RCCs. | 14627671 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation in serum of breast cancer patients: an independent prognostic marker. | 14633683 |
| Neoplastic disease | Epigenetic Alterations | Changes in the status of DNA methylation are one of the most common molecular alterations in human neoplasia. | 14633683 |
| Breast Carcinoma | Epigenetic Alterations | Because it is possible to detect these epigenetic alterations in the bloodstream of patients, we investigated whether aberrant DNA methylation in patient pretherapeutic sera is of prognostic significance in breast cancer. | 14633683 |
| Primary malignant neoplasm | Epigenetic Alterations | Using MethyLight, a high-throughput DNA methylation assay, we analyzed 39 genes in a gene evaluation set, consisting of 10 sera from metastasized patients, 26 patients with primary breast cancer, and 10 control patients. | 14633683 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation of particular genes in pretherapeutic sera of breast cancer patients, especially of RASSF1A/APC, is more powerful than standard prognostic parameters. | 14633683 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation is a key regulator of gene transcription and genomic stability, and alteration of DNA methylation is one of the most consistent epigenetic changes in human cancers. | 14634451 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Epigenetic inactivation of TSLC1 gene in nasopharyngeal carcinoma. | 14639656 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Frequent epigenetic inactivation of TSLC1 gene in NPC suggested that this gene is one of the target tumor suppressor genes of this endemic cancer. | 14639656 |
| Metastatic malignant neoplasm to brain | Epigenetic Alterations | Our data suggest an important role for gene methylation in the development of brain metastases, primarily involving epigenetic silencing of DAP-kinase, THBS1 and the cell-cycle regulators RB1/p16INK4a. | 14654977 |
| Behavior of tumor, Gastrointestinal Stromal Tumors, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The growing understanding of the epigenetic changes associated with cancer, including aberrant promoter methylation of tumor suppressor genes that afford selective growth advantages to human neoplasms, suggests that the characterization of gene methylation patterns among gastrointestinal stromal tumors (GISTs) may be useful for predicting tumor behavior. | 14675710 |
| Colorectal Carcinoma | Epigenetic Alterations | Aberrant DNA methylation occurs in a subset of colorectal cancers and is characterized by regional areas of hypermethylation at CpG islands. | 14676107 |
| Kidney Failure, Acute, Neoplasms | Epigenetic Alterations | Tumors with aberrant DNA methylation of CpG islands within promoter regions of the hMLH1, TIMP3, and ARF genes also contained higher levels of both 5,10-methylenetetrahydrofolate and FH4. | 14676107 |
| Restenosis | Epigenetic Alterations | These findings suggest the genetic contribution to stent restenosis and support the notion that the long dinucleotide GT repeat in promotor region may interfere with HO-1 gene transcription, leading to decreased vascular protection upon injury. | 14683741 |
| Childhood Medulloblastoma | Epigenetic Alterations | Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. | 14688019 |
| Childhood Medulloblastoma, Neoplasms | Epigenetic Alterations | To assess the role of aberrant epigenetic events in medulloblastoma and identify critical genes in its development, we profiled the promoter methylation status of 11 candidate tumour-suppressor genes (TSGs; p14(ARF), p15(INK4b), p16(INK4a), CASP8, HIC1, EDNRB, TIMP3, TP73, TSLC1, RIZ1 and RASSF1A) in medulloblastoma cell lines, primary tumours and the normal cerebellum. | 14688019 |
| Childhood Medulloblastoma | Epigenetic Alterations | Moreover, methylation of these genes in medulloblastoma cell lines was associated with their epigenetic transcriptional silencing and methylation-dependent re-expression following treatment with the DNA methyltransferase inhibitor, 5-aza-2-deoxycytidine. | 14688019 |
| Childhood Medulloblastoma | Epigenetic Alterations | We conclude that epigenetic TSG inactivation is a significant feature of medulloblastoma, and identify RASSF1A, HIC1 and CASP8 as potentially critical genes in its pathogenesis. | 14688019 |
| Primary malignant neoplasm | Epigenetic Alterations | Our results indicate that epigenetic alteration of these genes is a frequent event in oral cancer, and is an early event observed in normal oral mucosa of the patients, indicating the critical importance of the epigenetic alteration in chewing tobacco associated oral carcinogenesis. | 14693237 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Our results indicate that maspin may contribute to bladder cancer development and that DNA methylation and histone deacetylation may be important for regulating maspin gene activation in bladder cancer cells. | 14732229 |
| Neoplasms | Epigenetic Alterations | We have recently documented that the ATM promoter is a target for epigenetic silencing in cultured tumor cells. | 14744748 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Sequencing FANCA in the AML samples with FANCA deletions did not detect mutations in the second allele and there was no evidence of epigenetic silencing by hypermethylation. | 14749703 |
| Squamous cell carcinoma | Epigenetic Alterations | Genetic and epigenetic alterations of the blood group ABO gene in oral squamous cell carcinoma. | 14750174 |
| cervical cancer, Neoplasms | Epigenetic Alterations | DNA methylation in serum and tumors of cervical cancer patients. | 14760078 |
| DNA Mismatch Repair Protein MSH2, human | Epigenetic Alterations | Defective DNA mismatch repair results from genetic or epigenetic alterations that most frequently inactivate the genes hMLH1 and hMSH2. | 14760534 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | To analyze the genetic and epigenetic alterations of RUNX3 gene, a potential putative tumor suppressor gene, in hepatocellular carcinoma (HCC). | 14760761 |
| Acute leukemia | Epigenetic Alterations | Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias. | 14762685 |
| Neoplasms | Epigenetic Alterations | Differential expression of ER-alpha and ER-beta may alter the expression of key target genes (such as those induced by AP-1-dependent gene transcription), and contribute to the pathogenesis and clinical behavior of these tumors. | 14766247 |
| ovarian neoplasm, QPCT gene, Neoplasms | Epigenetic Alterations | Our results, therefore, suggest a potential role for epigenetic modification of these critical tumour suppressor genes in pathways relevant to the transformation and differentiation of rare type of ovarian cancer (GCTs). | 14970867 |
| Multiple Myeloma | Epigenetic Alterations | SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. | 14976049 |
| Multiple Myeloma | Epigenetic Alterations | The role of promoter hypermethylation leading to epigenetic inactivation of SOCS1 and SHP1 in myeloma was investigated. | 14976049 |
| Multiple Myeloma | Epigenetic Alterations | SHP1 methylation leading to epigenetic activation of the Jak/STAT pathway might have a tentative role in the pathogenesis of myeloma, which should be further confirmed by functional studies in primary myeloma samples. | 14976049 |
| Pheochromocytoma | Epigenetic Alterations | Genetic and epigenetic profile of sporadic pheochromocytomas. | 14985401 |
| Colorectal Cancer Pathway, Imprinting (Psychology) | Epigenetic Alterations | Loss of imprinting (LOI) of insulin-like growth factor-II (IGF-II) may be an inherited epigenetic trait that is polymorphic in the population, and its presence may predispose an individual to the development of colorectal cancer. | 14996863 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Our findings support the hypothesis that LOI of IGF-II is an epigenetic trait polymorphic in the population and suggest that LOI of IGF-II may play a role in colorectal cancer. | 14996863 |
| Stomach Carcinoma | Epigenetic Alterations | CDH1 promoter hypermethylation was found in 20 out of 70 gastric carcinomas and the epigenetic change occurred in the early, as well as in the locally advanced disease. | 14998854 |
| Unknown (origin) (qualifier value) | Epigenetic Alterations | Similar decreases in T cell DNA methylation occur in idiopathic lupus, potentially contributing to disease pathogenesis. | 15004168 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | Recent data implicate HP in the pathogenesis of colorectal cancers (CRC) characterised by extensive DNA methylation and microsatellite instability. | 15016754 |
| Neoplasms | Epigenetic Alterations | DNA methylation was tested in methylated in tumour (MINT) loci (1, 2, 12, 31) and genes HPP1, MGMT, p14ARF, p16INK4a, and hMLH1. | 15016754 |
| Prostate Cancer Pathway | Epigenetic Alterations | Aberrant DNA methylation patterns may be the earliest somatic genome changes in prostate cancer. | 15026333 |
| Retinitis Pigmentosa | Epigenetic Alterations | To avoid inaccurate risk assessment for RP due to epigenetic events, such as the rare occurrence of germ line mosaicism, genetic counseling in families with XLRP should always be guided by molecular testing. | 15032968 |
| Neoplasms | Epigenetic Alterations | Therefore, DNA methylation pattern might be a useful tool to give a primary diagnosis of a brain tumor or as a marker for the early detection of the relapse of the disease. | 15037658 |
| Neoplasms | Epigenetic Alterations | A simple epigenetic method for the diagnosis and classification of brain tumors. | 15037658 |
| Bile duct carcinoma | Epigenetic Alterations | hTERT gene transcription and protein expression is most likely involved in the proliferation and malignant transformation of bile epithelia and the malignant progression of bile duct carcinomas. | 15059327 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Epigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets. | 15059895 |
| Carcinogenesis | Epigenetic Alterations | Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning. | 15059896 |
| Malignant Neoplasms | Epigenetic Alterations | This methylation screening strategy should identify additional genes inactivated by epigenetic silencing in colorectal and other cancers. | 15059896 |
| Neoplasms | Epigenetic Alterations | This data strongly supports the hypothesis that overexpression of transdominant p73 isoforms can function as epigenetic inhibitors of p53 in vivo, thereby alleviating selection pressure for p53 mutations in tumors. | 15059898 |
| Multiple malignancy | Epigenetic Alterations | Germline epimutation of MLH1 in individuals with multiple cancers. | 15064764 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | We hypothesized that an epimutation could occur in any gene as a germline event that predisposes to disease and looked for examples in tumor suppressor genes in individuals with cancer. | 15064764 |
| Embryonic Mosaic | Epigenetic Alterations | The mosaicism and nonmendelian inheritance that are characteristic of epigenetic states could produce patterns of disease risk that resemble those of polygenic or complex traits. | 15064764 |
| Carcinogenesis | Epigenetic Alterations | These results suggest that inactivation of the ATP2A2 gene is a frequent and early event during oral carcinogenesis and that loss of expression may be regulated partly by an epigenetic mechanism. | 15069686 |
| Pancreatic carcinoma | Epigenetic Alterations | In conclusion, the marked over-expression of 14-3-3sigma in PADC together with multiple known genetic and epigenetic alterations of potential 14-3-3sigma interacting partners suggests an important role of aberrant 14-3-3sigma downstream signaling in pancreatic cancer. | 15073049 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The development and application of these new genetic and epigenetic markers with high specificity and sensitivity for PCa in serum and PJ will significantly improve our diagnostic accuracy. | 15084968 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation is a common molecular alteration in colorectal cancer cells. | 15094274 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Whether a combination of genetic and epigenetic markers will identify colorectal cancer at an early stage remains to be shown. | 15094274 |
| Carcinoma, Ovarian Epithelial | Epigenetic Alterations | Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation. | 15102672 |
| ovarian neoplasm | Epigenetic Alterations | Our findings suggest that 14-3-3 sigma is inactivated mainly by aberrant DNA methylation and that it may play an important role in the pathogenesis of epithelial ovarian cancer. | 15102672 |
| Primary Malignant Liver Neoplasm, Neoplasms | Epigenetic Alterations | The p53 tumor suppressor gene is known to play an important role in carcinogenesis of different tissues being involved in gene transcription, DNA synthesis and repair and somatic mutations of p53 are common in primary liver cancer. | 15105048 |
| Arteriosclerosis | Epigenetic Alterations | Taken together, our results unequivocally show that alterations in DNA methylation profiles are early markers of atherosclerosis in a mouse model and may play a causative role in atherogenesis. | 15131116 |
| Behavior, Ameloblastic Carcinoma | Epigenetic Alterations | We conclude that other genetic or epigenetic mechanisms may be responsible for malignant behavior in ameloblastic carcinomas. | 15133474 |
| Clinical Coordinator | Epigenetic Alterations | In this study, 67 sporadic CRC and eight samples of normal bowel were analysed for MSI status (by SSCP) and levels of MLH1, MSH2 and p53 gene transcription (by RT-PCR and scanning densitometry). | 15138486 |
| Pancreatic carcinoma, Aggressive behavior | Epigenetic Alterations | Pancreatic cancer is an aggressive malignancy that exhibits a number of genetic and epigenetic alterations. | 15146555 |
| cervical cancer | Epigenetic Alterations | A DNA methylation pattern similar to normal tissue is associated with better prognosis in human cervical cancer. | 15159026 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Interestingly, statistically significantly less patients whose tumor DNA methylation pattern clustered together with normal cervical tissue died within our observation period, as compared to those patients out of the three remaining clusters (P < 0.03) Cervical cancer patients, whose DNA methylation pattern clustered together with normal cervical tissue revealed a strong trend to better survival (P = 0.066) compared to patients grouped in the remaining cluster. | 15159026 |
| Acute lymphocytic leukemia, Lymphoma, Large-Cell, Follicular | Epigenetic Alterations | These data are in accordance with the hypothesis that polymorphisms in the genes for folate and methionine metabolism might play a greater role in the occurrence of ALL than NHL by influencing DNA synthesis and/or DNA methylation. | 15159311 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Further study is needed focusing on ethnic variations in the relationships among MTHFR polymorphism, DNA methylation and the development of CIMP(+) colorectal cancer. | 15161007 |
| cervical cancer | Epigenetic Alterations | Furthermore, the epigenetic regulation of p73 expression via DNA methylation was also investigated in 103 cervical cancers and 124 normals. | 15161684 |
| Malignant neoplasm of lung | Epigenetic Alterations | In this study, we report for the first time reduced expression of the let-7 microRNA in human lung cancers. | 15172979 |
| Malignant neoplasm of lung | Epigenetic Alterations | Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. | 15172979 |
| cervical cancer | Epigenetic Alterations | Contribution of epigenetic risk factors but not p53 codon 72 polymorphism to the development of cervical cancer in Northeastern Thailand. | 15183536 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma. | 15184253 |
| Lupus Erythematosus | Epigenetic Alterations | Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. | 15188362 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | We then determined whether CD70 is overexpressed on T cells treated with other DNA methylation inhibitors and on SLE T cells, and determined its functional significance. | 15188362 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | SLE T cells and T cells treated with DNA methylation inhibitors overexpressed CD70 and overstimulated B cell IgG production. | 15188362 |
| Gammopathy | Epigenetic Alterations | DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. | 15197802 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers. | 15201980 |
| Malignant neoplasm of kidney, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | To gain insight into the role of epigenetic silencing of tumor suppressor and cancer genes in kidney tumorigenesis, we determined a hypermethylation profile of kidney cancer. | 15217927 |
| melanoma | Epigenetic Alterations | PE SLNs (n = 308) from these patients were sectioned and assessed by qRT for mRNA of four melanoma-associated genes: MART-1 (antigen recognized by T cells-1), MAGE-A3 (melanoma antigen gene-A3 family), GalNAc-T (beta1-->4-N-acetylgalactosaminyl-transferase), and Pax3 (paired-box homeotic gene transcription factor 3). | 15226334 |
| Malignant neoplasm of breast | Epigenetic Alterations | The CDH13/Sat2 epigenetic correlation was seen also in breast cancers. | 15231656 |
| Serrated intestinal polyps, Rectal Carcinoma | Epigenetic Alterations | BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. | 15247181 |
| Clinical Coordinator | Epigenetic Alterations | The BRAF mutation was frequently seen in SSA and in sporadic MSI-H CRC, both of which were associated with DNA methylation. | 15247181 |
| Malignant Neoplasms, Adenoma | Epigenetic Alterations | Sporadic MSI-H cancers may originate in SSA and not adenomas, and BRAF mutation and DNA methylation are early events in this "serrated" pathway. | 15247181 |
| Breast Carcinoma | Epigenetic Alterations | Although the number of samples was relatively small, our results suggest that DNA methylation in ERalpha and ERbeta are present in breast cancer tissue, and that the methylation causes a significant effect on transcriptional silencing. | 15254780 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Using genetic and epigenetic analyses, we examined various molecular alterations including the loss of protein and mRNA expression, and 5CpG hypermethylation, allelic imbalance, and mutation of the p14ARF gene in a series of 102 NSCLC samples, in parallel with clinicopathological and prognostic analyses. | 15269146 |
| Malignant neoplasm of kidney | Epigenetic Alterations | We investigated the feasibility of detecting aberrant DNA methylation in the urine and serum samples of renal cancer patients. | 15289362 |
| Neoplasms | Epigenetic Alterations | There were no significant correlations between DNA methylation in tumor, margins, or bronchoalveolar fluid specimens and either regional recurrence or distant metastases. | 15297416 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | We hypothesized that DNA promoter hypermethylation changes at bronchial margins could be detected in patients with no histological evidence of malignancy and that they would reflect epigenetic events in the primary tumor. | 15297416 |
| Neoplasms | Epigenetic Alterations | Concordance of one gene with an identical epigenetic change in the tumor or bronchial margin was observed in 85% of patients. | 15297416 |
| Malignant Neoplasms | Epigenetic Alterations | These results suggest that loss of function of HELLS/SMARCA6 by allelic loss and aberrant proteins by tumor-specific exon creation may result in epigenetic deregulation, leading lung cells to malignancy or its progression. | 15305370 |
| Neoplasms | Epigenetic Alterations | Our data suggest that the t(6;14) translocation may be extremely uncommon in FL and that a deregulated expression of cyclin D3, possibly due to epigenetic mechanisms, may be involved in the pathogenesis of high-grade tumors. | 15305377 |
| Multiple Myeloma | Epigenetic Alterations | DNA methylation changes in multiple myeloma. | 15318245 |
| Squamous cell carcinoma, Adenocarcinoma, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | DNA methylation analysis of the proximal promoter region of this gene revealed abnormal hypermethylation in 67% of the adenocarcinomas and 50% of squamous cell carcinomas, indicating that epigenetic mechanisms are involved in silencing this gene in NSCLC. | 15328519 |
| Neoplasms | Epigenetic Alterations | DNA methylation patterns in the CpG island of the MGMT gene were determined in every tumor by methylation specific PCR (MSP). | 15332332 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Epigenetic mechanism might be associated with reduced expression of FHIT in a part of ESCC cases. | 15363189 |
| Meningioma | Epigenetic Alterations | DNA methylation of multiple promoter-associated CpG islands in meningiomas: relationship with the allelic status at 1p and 22q. | 15365725 |
| Meningioma | Epigenetic Alterations | The purpose of this research was to examine the DNA methylation profile of meningiomas. | 15365725 |
| Meningioma, Neoplasms | Epigenetic Alterations | Our findings indicate that aberrant DNA methylation of promoter-associated CpG islands in meningiomas contributes to the development of these tumors. | 15365725 |
| Meningioma | Epigenetic Alterations | These meningiomas primarily accumulated the epigenetic changes of THBS1 (14/30; 47%; P < 0.005), TIMP-3 (12/30; 40%; P < 0.05), p73 (10/30; 26%; P < 0.02) and p14(ARF) /p16(INK4a)(7/30 each one; 23%; not significant). | 15365725 |
| Antigen-Presenting Cells | Epigenetic Alterations | We found a clear change in the expression level of the gene transcription product of APC in canceration of oral squamous epithelium and the differentiation of oral SCC. | 15380172 |
| Primary malignant neoplasm | Epigenetic Alterations | Gene promoter hypermethylation is increasingly recognized to play an important role in cancer development through silencing of gene transcription. | 15386372 |
| Breast Carcinoma | Epigenetic Alterations | A number of different genes are known to be inactivated by aberrant hypermethylation in breast cancer, but it is still unknown to what extent these epigenetic alterations differ according to specific breast cancer phenotypes. | 15447983 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Aberrant methylation of 5 gene promoter regions is an epigenetic phenomenon that is a major mechanism for silencing of tumor suppressor genes in many cancer types. | 15447999 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Although the mutator phenotype, including genetic and epigenetic alterations of the mismatch repair (MMR) system, seems to be pronounced in familial colorectal cancer, there have been few integrative studies comprising the entire mutator pathway. | 15448003 |
| Neoplastic disease, Primary malignant neoplasm | Epigenetic Alterations | The genetic and epigenetic alterations that initiate and drive cancer can be used as targets for detection of neoplasia in bodily fluids. | 15448006 |
| Malignant Neoplasms | Epigenetic Alterations | Promoter hypermethylation of CpG islands in tumor-related genes can lead to their transcriptional inactivation, and this epigenetic mechanism has been shown to participate in MGMT silencing in some cancers, including those affecting the nervous system. | 15450401 |
| teratologic, Neoplasms | Epigenetic Alterations | Accordingly, a link between both genetic and epigenetic anomalies may exist in these neoplasms. | 15450401 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic silencing of O(6)-methylguanine-DNA methyltransferase (MGMT) by promoter methylation can confer cancer cells with an increased sensitivity to alkylating chemotherapeutic agents and a higher susceptibility to TP53 transition mutations. | 15455376 |
| Carcinoma of lung | Epigenetic Alterations | Anthracotic index and DNA methylation status of sputum contents can be used for identifying the population at risk of lung carcinoma. | 15481085 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | The investigations on the role of DNA methylation in carcinogenesis have been mainly focused on promoter hypermethylation of tumor suppressor genes. | 15487509 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | As a number of genes associated with cancer development may be influenced by DNA methylation, identification of these genes is of great importance for understanding the epigenetic alteration in carcinogenesis. | 15487509 |
| Carcinoma of lung | Epigenetic Alterations | The hypermethylated DNA fragments identified in this study might be specific epigenetic alterations in the Chinese lung cancer. | 15487509 |
| Neoplasms | Epigenetic Alterations | Epigenetic silencing of multiple genes seen in some tumors is at best rarely the result of an inherited defect in the methylation apparatus. | 15492290 |
| MICROPHTHALMIA, SYNDROMIC 7 | Epigenetic Alterations | Methylation of E-cadherin and RARbeta occurs preferentially in AMLs with high methylation index (MI), while epigenetic lesions in SOCS1, DAP-kinase, and p15 appear to be independent. | 15495254 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study. | 15502094 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression, and modality of treatment were observed. | 15507473 |
| Myeloid Leukemia | Epigenetic Alterations | Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities. | 15507473 |
| Liver carcinoma | Epigenetic Alterations | We provide evidence indicating that epigenetic mechanisms, involving DNA methylation and histone deacetylation, may play a role in the silencing of MTAP gene expression in hepatocarcinoma. | 15511635 |
| Stomach Carcinoma | Epigenetic Alterations | The up-regulation of proto-oncogene may be the consequence of epigenetic control of gene expression by demethylase, and mbd2 is involved in the regulation of hMSH2 expression in human gastric cancer. | 15526354 |
| Carcinoma of lung | Epigenetic Alterations | Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. | 15528220 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. | 15542810 |
| Carcinogenesis | Epigenetic Alterations | Changes in DNA methylation can be detected with a high degree of sensitivity, so we used the MethyLight assay to determine how methylation patterns of apoptosis-associated genes change during bladder carcinogenesis and whether DNA methylation could be detected in urine sediments. | 15569975 |
| Primary malignant neoplasm | Epigenetic Alterations | There is increasing evidence for a fundamental role for epigenetic silencing of apoptotic pathways in cancer. | 15569975 |
| Colorectal Carcinoma | Epigenetic Alterations | Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis. | 15569977 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | The epigenetic inactivation of ID4 gene on colorectal cancer (CRC) development and its clinical significance was assessed. | 15569977 |
| Hepatocarcinogenesis, Neoplasms | Epigenetic Alterations | The tumor suppressor gene p16INK4A is mainly inactivated by an epigenetic change involving promoter hypermethylation in hepatocarcinogenesis. | 15569978 |
| Carcinoma of lung | Epigenetic Alterations | These epigenetic changes in the GATA genes in lung cancer are tumor-specific, relate to the loss of GATA gene expression, and occur increasingly in the elderly. | 15585625 |
| Carcinogenesis | Epigenetic Alterations | We elucidated the significance of aberrant DNA methylation on pericentromeric satellite regions during urothelial carcinogenesis. | 15592089 |
| Rhabdomyosarcoma | Epigenetic Alterations | In addition to exemplifying developmental dysregulation, methylation of PAX3 has potential in the development of an epigenetic profile for the diagnosis of rhabdomyosarcoma. | 15602708 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Epigenetic alteration, via promoter hypermethylation, inactivates genes important for the development of head and neck squamous cell carcinoma (SCCHN). | 15635575 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Neoplasms | Epigenetic Alterations | To detect epigenetic changes in head and neck squamous cell carcinoma (HNSCC) and between metastatic and nonmetastatic tumors, we performed a systematic phosphorylation screening on different protein kinases. | 15641106 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic events such as promoter hypermethylation have been implicated in prostate carcinogenesis. | 15649863 |
| Alcoholic Intoxication, Chronic | Epigenetic Alterations | We observed a significant increase of the alpha synuclein promoter DNA methylation in patients with alcoholism which was significantly associated with their elevated homocysteine levels. | 15671870 |
| Neoplasms | Epigenetic Alterations | In contrast, this epigenetic modification was shown in only three of 23 tumours in which no decrease in TFPI-2 synthesis was found (P=0.016). | 15685245 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These results show that epigenetic inactivation of RASSF1A cannot be a prognostic marker of NSCLC. | 15700308 |
| Fecal occult blood test, Adenoma | Epigenetic Alterations | We explored the potential of a single epigenetic marker in comparison with fecal occult blood testing (FOBT) for the discrimination of patients with CRCs and adenomas from those without. | 15704048 |
| Adenoma | Epigenetic Alterations | We postulate that a panel of merely a few genetic and epigenetic markers will be required for the highly sensitive and specific detection of CRCs and adenomas in fecal samples from affected patients. | 15704048 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation of CRBP1, MINT31 or CDH13 was not correlated between cancers and ACF from the same patients. | 15704093 |
| Malignant neoplasm of liver, Loss of Heterozygosity | Epigenetic Alterations | Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors. | 15704097 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | Previously, the RASSF1A, BLU and SEMAPHORIN 3B (SEMA3B) candidate tumor suppressor genes on chromosome 3p21.3 were found to be inactivated and downregulated by genetic and epigenetic changes in lung cancer. | 15704097 |
| Malignant neoplasm of liver | Epigenetic Alterations | In conclusion, our data indicate that 2-hit gene silencing of SEMA3B through epigenetic changes and allele loss is a common and important event in the carcinogenesis of malignant liver tumors. | 15704097 |
| Carcinoma of lung | Epigenetic Alterations | Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer. | 15709192 |
| Malignant Neoplasms, Carcinogenesis | Epigenetic Alterations | DNA methylation changes are an early event in carcinogenesis and are often present in the precursor lesions of various cancers. | 15713962 |
| cervical cancer, Cervical Intraepithelial Neoplasia | Epigenetic Alterations | We examined whether DNA methylation changes might be used as markers of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC). | 15713962 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Epigenetic silencing of cellular retinol-binding proteins in nasopharyngeal carcinoma. | 15720818 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Recently, we have demonstrated frequent epigenetic inactivation of a retinoic acid receptor (RAR), RARbeta2, in nasopharyngeal carcinoma (NPC). | 15720818 |
| Primary malignant neoplasm | Epigenetic Alterations | Our findings implied that epigenetic disruption of the CRBPs, CRBPI and CRBPIV, is important in NPC tumorigenesis and may contribute to the loss of retinoic acid responsiveness in cancer. | 15720818 |
| Malignant Neoplasms | Epigenetic Alterations | Emerging evidence suggests that microRNA, which are well-conserved, abundant and small regulatory RNA, may be involved in the pathogenesis of human cancers. | 15723655 |
| Breast Carcinoma | Epigenetic Alterations | We analyzed RASSF1A DNA methylation in pretherapeutic sera and serum samples collected 1 year after surgery from 148 patients with breast cancer who were receiving adjuvant tamoxifen; 19.6% and 22.3% of patients with breast cancer showed RASSF1A DNA methylation in their pretherapeutic and 1-year-after serum samples, respectively. | 15734995 |
| Malignant Neoplasms, Hollings Cancer Center | Epigenetic Alterations | In addition to their known epigenetic or genetic abnormality in malignancies, these findings suggest that altered transcription of these two imprinted genes contributes to progression of HCC. | 15736456 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. | 15746151 |
| SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Aberrant DNA methylation is frequently observed in adults with myelodysplastic syndrome (MDS), and is recognized as a critical event in the diseases pathogenesis and progression. | 15755284 |
| Neoplasms | Epigenetic Alterations | We previously identified apolipoprotein D (Apo D) as a novel tumor suppressor gene based on the pharmacological unmasking of epigenetic silencing. | 15756681 |
| Neoplasms | Epigenetic Alterations | In addition, tumors with an advanced pathological stage showed epigenetic alteration of the RAS association domain family 1A promoter with a higher frequency. | 15758578 |
| Carcinoma of lung | Epigenetic Alterations | Detection of epigenetic alterations in serum may provide basis for the early and noninvasive lung cancer diagnosis and customized therapy. | 15758578 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant methylation of DNA has been shown to play an important role in a variety of human cancers, developmental disorders and aging. | 15760842 |
| Clinical Coordinator, Carcinogenesis, Colorectal Carcinoma | Epigenetic Alterations | A distinctive pathway of colorectal carcinogenesis termed CpG island methylator phenotype is characterized by extensive DNA methylation in colorectal carcinoma (CRC) cells but not in nonneoplastic mucosa. | 15767794 |
| Hereditary hemorrhagic telangiectasia, Epistaxis | Epigenetic Alterations | Epistaxis in hereditary hemorrhagic telangiectasia (HHT; Rendu-Osler-Weber syndrome) is a frequent symptom that may be caused by a multitude of different genetic and epigenetic phenomena. | 15794077 |
| Cartilaginous exostosis, Chondrosarcoma, Exostosin-2 | Epigenetic Alterations | To evaluate promoter methylation (which is an epigenetic gene silencing mechanism) of EXT1 and EXT2, we performed methylation-specific polymerase chain reaction (PCR) for 20 chondrosarcoma cases (12 primary, 3 secondary to osteochondroma, 2 secondary to enchondromatosis, 2 extraskeletal ordinary, and 1 clear cell) and in five cell lines. | 15796962 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | This is the first time that the significance of p53 promoter methylation status is described in this pathology, and our data support that this epigenetic phenomenon could be involved in the pathogenesis and clinical evolution of CLL. | 15801955 |
| Colorectal Carcinoma | Epigenetic Alterations | Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability. | 15802015 |
| Admitting diagnosis | Epigenetic Alterations | In order to address transcriptional changes associated with this selective vulnerability, we used subtractive hybridization of transcripts derived from human frontal cortex, which degenerates in late stages of AD, against transcripts of the inferior temporal cortex, which is affected both heavily and early in the course of AD. | 15813938 |
| Hollings Cancer Center | Epigenetic Alterations | These data suggest that PAP expression designate a subset of low-grade, low-stage HCC with frequent beta-catenin mutation and hence more favorable prognosis, whereas further genetic or epigenetic alterations, such as p53 mutation and REG1A expression, lead to more advanced HCCs. | 15814635 |
| Adenoma of large intestine | Epigenetic Alterations | Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. | 15831910 |
| Adenoma of large intestine | Epigenetic Alterations | The hypothesis that folic acid supplementation increases DNA methylation in leucocytes and colorectal mucosa was tested in 31 patients with histologically confirmed colorectal adenoma using a randomised, double blind, placebo controlled, parallel design. | 15831910 |
| Acute lymphocytic leukemia | Epigenetic Alterations | To study the relationship between protein expression and DNA methylation of a triad of cell-cycle regulatory genes known to be frequently methylated in adult acute lymphocytic leukemia (ALL). | 15851765 |
| cervical cancer | Epigenetic Alterations | This phase I study evaluated the tolerability and its effects upon DNA methylation and gene reactivation in patients with untreated cervical cancer. | 15862127 |
| Neoplasms | Epigenetic Alterations | Hydralazine at doses between 50 and 150 mg/day is well tolerated and effective to demethylate and reactivate the expression of tumor suppressor genes without affecting global DNA methylation. | 15862127 |
| Rett Syndrome | Epigenetic Alterations | This observation adds another dimension to the epigenetic factors that may contribute to the phenotype in RTT. | 15862188 |
| Breast Carcinoma | Epigenetic Alterations | Thus, down-regulation of the HIVEP2 genes frequently occurs and may be one of the genetic events responsible for breast cancer, and their transcription may be regulated by complex mechanisms involving interactions with other factors and/or by other genetic/epigenetic mechanisms. | 15868437 |
| Carcinogenesis | Epigenetic Alterations | Vitamin B6, whose main circulating form is pyridoxal 5-phosphate (PLP), is important in one-carbon metabolism, which is critical for DNA synthesis and DNA methylation, both of which are potentially involved in colorectal carcinogenesis. | 15870439 |
| Gastric Adenocarcinoma, PGC gene, "Barretts Adenocarcinoma", Best Case Imputation Technique | Epigenetic Alterations | Although the incidence of Barretts carcinomas (BC) and proximal gastric adenocarcinomas (PGC) is increasing, little is known about different epigenetic changes in these etiopathogenetically distinct entities. | 15870861 |
| Neoplasms | Epigenetic Alterations | This is the first report on promoter methylation of death-associated protein kinase (DAPK) and fragile histidine triad gene (FHIT) in BC; both DAPK (BC 0.7, JC 0.92 and PGC 0.86) and FHIT (BC 0.88, JC 1.0 and PGC 1.0) were found to be highly methylated, suggesting that epigenetic silencing of these tumor suppressors is a common event in adenocarcinomas of the upper gastrointestinal tract, including BC. | 15870861 |
| Neoplasms | Epigenetic Alterations | This might constitute an early epigenetic precursor lesion in the normally-appearing tissue surrounding the tumor. | 15870861 |
| Neoplasms | Epigenetic Alterations | Realization that many tumor suppressor genes are silenced by epigenetic mechanisms has stimulated the discovery of novel tumor suppressor genes. | 15886297 |
| Neoplasms | Epigenetic Alterations | The Ras-association domain family 1A (RASSF1A) tumour suppressor gene is inactivated in a variety of solid tumours, usually by epigenetic silencing of the promoter and/or allelic loss of its locus at 3p21.3. | 15887288 |
| Glaucoma, Primary Open Angle | Epigenetic Alterations | TAP1-1 and TAP1-2 gene polymorphisms may, by way of post-transcriptional changes and altered regulation of gene expression, be involve the immune system in the development of POAG. | 15887980 |
| Sarcoma | Epigenetic Alterations | Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas. | 15891996 |
| Malignant Neoplasms | Epigenetic Alterations | Hypermethylation of promoter CpG islands is a common epigenetic event in a variety of human cancers. | 15892004 |
| Meningioma | Epigenetic Alterations | In conclusion, this study demonstrates that aberrant hypermethylation profile is associated with atypical and anaplastic meningiomas, suggesting that epigenetic change may be involved in malignant progression of meningiomas. | 15892004 |
| Lymphoma, T-Cell, Cutaneous, Neoplasms | Epigenetic Alterations | Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. | 15897551 |
| TSPYL2 wt Allele, Lymphoma, T-Cell, Cutaneous | Epigenetic Alterations | To analyze the occurrence of promoter hypermethylation in primary cutaneous T-cell lymphoma (CTCL) on a genome-wide scale, focusing on epigenetic alterations with pathogenetic significance. | 15897551 |
| Breast Carcinoma | Epigenetic Alterations | Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer. | 15899800 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation in the promoter regions of genes is a prominent epigenetic gene silencing mechanism that contributes to breast cancer biology. | 15899800 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Using a microarray-based technology, the promoter DNA methylation status of 117 candidate genes was studied in a cohort of 200 steroid hormone receptor-positive tumors of patients who received the antiestrogen tamoxifen as first-line treatment for recurrent breast cancer. | 15899800 |
| Carcinogenesis | Epigenetic Alterations | Gene silencing due to aberrant DNA methylation plays an important role in carcinogenesis. | 15911243 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Methylation of several CpG islands was frequently found in normal lung tissue of cancer patients and this may have been attributed to epigenetic field defect and/or infiltrating tumour cells. | 15911247 |
| Neoplasms, Biliary Tract Cancer | Epigenetic Alterations | Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers. | 15915369 |
| Liver and Intrahepatic Biliary Tract Carcinoma | Epigenetic Alterations | Thus, we examined epigenetic (promoter methylation) and genetic (gene mutation) alterations in biliary tract cancer. | 15915369 |
| Liver and Intrahepatic Biliary Tract Carcinoma | Epigenetic Alterations | Reduced MGMT expression may increase the malignant potential of biliary tract cancer through both epigenetic and genetic mechanisms. | 15915369 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | Our results showed that, while candidate tumor suppressor genes at this locus can be simultaneously inactivated by epigenetic alterations, loss of heterozygosity without any hypermethylation of the three genes can also occur in some cases, suggesting that just one allelic loss might also be sufficient for the inactivation of any of these genes for lung cancer development. | 15922865 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | It is noteworthy that, in all of the methylated GISTs, the epigenetic promoter alteration was coupled with mRNA expression. | 15929122 |
| Stomach Carcinoma | Epigenetic Alterations | These results suggest that the detection of DNA methylation in the serum may carry both diagnostic and therapeutic values in gastric cancer patients. | 15942635 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Aberrant DNA methylation is a frequent phenomenon in non-small cell lung cancers. | 15942649 |
| Squamous cell carcinoma, Adenocarcinoma | Epigenetic Alterations | The highest degree of differential DNA methylation in squamous cell carcinoma compared to normal was observed in ARHI, MGMT, GP1bbeta, RARbeta and TMEFF2 genes, while TMEFF2, MGMT and CDKNIC genes differentiated between adenocarcinomas and normal tissue. | 15942649 |
| Neoplasms | Epigenetic Alterations | Of the 60 tumors, DNA methylation of the p16(INK4a) promoter was detected in 28 tumors (47%); the respective values DNA methylation of the RASSF1A, DAPK, and MGMT promoters were 25 tumors (42%), 16 tumors (27%), and 4 tumors (7%), respectively. | 15959912 |
| Neoplasms | Epigenetic Alterations | Forty-six tumors (77%) had DNA methylation in > or = 1 of the 4 promoters, 20 tumors (33%) had DNA methylation in > or = 2 promoters, 6 tumors (10%) had DNA methylation in > or = 3 promoters, and 1 tumor (2%) had DNA methylation in all 4 promoters. | 15959912 |
| SERPINB3 wt Allele | Epigenetic Alterations | Our results suggest that DNA methylation of multiple genes, especially hypermethylation of the p14ARF promoter, is common in OSCC and is associated with the use of tobacco and/or alcohol consumption. | 15975525 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Aberrant DNA methylation of a cell cycle regulatory pathway composed of P73, P15 and P57KIP2 is a rare event in children with acute lymphocytic leukemia. | 15978938 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Aberrant DNA methylation of multiple promoter associated CpG islands is a frequent phenomenon in acute lymphocytic leukemia (ALL). | 15978938 |
| Acute lymphocytic leukemia | Epigenetic Alterations | These results indicate that differences in DNA methylation of specific molecular pathways may contribute to the prognostic differences known to occur between pediatric and adult patients with ALL. | 15978938 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | We, therefore, examined, in a population-based study of human bladder cancer, the relationship between epigenetic silencing of three tumor suppressor genes, p16(INK4A), RASSF1A and PRSS3, and exposure to both tobacco and arsenic in bladder cancer. | 15987713 |
| Bladder Neoplasm | Epigenetic Alterations | These results, from human bladder tumors, add to the body of animal and in vitro evidence that suggests a role in epigenetic alterations for bladder carcinogens. | 15987713 |
| Schizophrenia | Epigenetic Alterations | The association of a specific epigenetic mark, H3-(methyl)-lysine 4, with the molecular architecture of glutamatergic signaling in human brain has potential implications for schizophrenia and other disorders with altered glutamate receptor function. | 15998284 |
| ovarian neoplasm | Epigenetic Alterations | We analyzed the DNA methylation status and mRNA expression of p15INK4b and p16INK4a in 52 ovarian cancer specimens and 40 normal ovarian specimens by using methylation-specific PCR and real-time reverse transcription-PCR, respectively. | 16000597 |
| Carcinogenesis, ovarian neoplasm | Epigenetic Alterations | Our results suggest that epigenetic alterations in p15INK4b but not p16INK4a have an important role in ovarian carcinogenesis and that mechanisms other than methylation may exist to reduce gene expression of p15INK4b in ovarian cancer. | 16000597 |
| cervical cancer, Neoplasms | Epigenetic Alterations | Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. | 16001982 |
| Primary malignant neoplasm | Epigenetic Alterations | The development of cancer has been associated with epigenetic alterations such as aberrant histone deacetylase (HDAC) activity. | 16001982 |
| Carcinogenesis | Epigenetic Alterations | We conclude that epigenetic inactivation of the PTGIS gene is a recurrent alteration in colorectal carcinogenesis. | 16007128 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic silencing of the PRSS3 putative tumor suppressor gene in non-small cell lung cancer. | 16013053 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | As epigenetic alteration is common in non-small cell lung cancer (NSCLC), we sought to determine if promoter hypermethylation of PRSS3 occurred in this disease, and if it was associated with clinical features of NSCLC or tobacco-related exposures in these patients. | 16013053 |
| Hereditary nonpolyposis colorectal carcinoma, Colorectal Carcinoma | Epigenetic Alterations | The current data showed instead that the BRAF V599E mutation was associated only with a subgroup of colorectal carcinomas with MSI that were obtained from older patients without hereditary nonpolyposis colorectal carcinoma and showed epigenetic silencing of hMLH1. | 16015629 |
| Neoplasms | Epigenetic Alterations | These results indicated that tumors with MSI caused by epigenetic MLH1 silencing have a distinct mutational background from that of tumors with genetic loss of mismatch repair, suggesting that there are two genetically distinct entities of microsatellite-instable tumors. | 16015629 |
| Head and Neck Carcinoma | Epigenetic Alterations | DNA methylation in the CTCF-binding site I and the expression pattern of the H19 gene: does positive expression predict poor prognosis in early stage head and neck carcinomas? | 16015666 |
| Calcibiotic Root Canal Sealer | Epigenetic Alterations | Although extensive methylation of CpG islands within the promoter regions of DNA mismatch repair genes such as MLH1 is thought to play a central role in tumorigenesis for MSI-positive sporadic CRCs, it has been obscure whether such aberrant epigenetic regulation occurs more widely and affects other cancer-related genes in vivo. | 16033773 |
| Carcinogenesis | Epigenetic Alterations | Common polymorphisms at the MTHFR nucleotides position 677 (C-T) and a 28-bp tandem repeat polymorphism (2R or 3R) in the TS promoter enhancer region (TSER) have been reported to be functional and are supposed to disturb the normal DNA methylation and synthesis leading to carcinogenesis. | 16045580 |
| Carcinogenesis | Epigenetic Alterations | One-carbon metabolism, in which folate plays an essential role, is involved in DNA methylation and synthesis, and is suspected of impacting on colorectal carcinogenesis. | 16051637 |
| Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation has been shown to play an important role during multistage carcinogenesis in various human organs. | 16053511 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic events, especially those involving alterations in the breast stromal microenvironment, may play an important role in radiation-induced carcinogenesis but remain not well understood. | 16061655 |
| Epithelioma, Carcinogenesis | Epigenetic Alterations | The aim of this study was to compare the promoter hypermethylation profiles of ovarian epithelial neoplasms to better understand the role of epigenetic silencing in carcinogenesis. | 16061849 |
| Malignant neoplasm of ovary | Epigenetic Alterations | Promoter hypermethylation is a frequent epigenetic event that occurs most commonly in invasive epithelial ovarian carcinomas. | 16061849 |
| Non-Small Cell Lung Carcinoma, Loss | Epigenetic Alterations | In NSCLC, loss of PTEN protein expression occurs frequently, although the mechanism responsible for loss is not clearly attributable to deletion or epigenetic silencing. | 16084946 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer. | 16103055 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Using a population-based study of bladder cancer (n = 355), we examined epigenetic alterations, specifically gene promoter hypermethylation, of four SFRP genes in addition to immunohistochemical staining of TP53, which has been previously shown to be a predictor of invasive disease. | 16103055 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Aberrant methylation of 5gene promoter regions associated with gene silencing is an epigenetic phenomenon responsible for silencing of tumor suppressor genes in many cancer types. | 16108009 |
| Carcinogenesis | Epigenetic Alterations | Recent data suggest that epigenetic abnormalities may occur very early in lung carcinogenesis. | 16129599 |
| Stomach Carcinoma | Epigenetic Alterations | DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation. | 16134180 |
| Carcinogenesis | Epigenetic Alterations | The results suggested that gastric carcinogenesis involves transcriptional inactivation by aberrant DNA methylation of genes related to retinoid signaling. | 16134180 |
| Malignant Neoplasms, Metastasis | Epigenetic Alterations | Loss of epigenetic control of synuclein-gamma gene as a molecular indicator of metastasis in a wide range of human cancers. | 16140929 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | By performing genomic sequencing and methylation-specific PCR assays, we identify an inclusive demethylation of CpG sites within the CpG island of SNCG gene in every tumor sample (100%) across all cancer types, illustrating a universal loss of the epigenetic control of SNCG gene expression in tumors and further demonstrating that the demethylation of SNCG CpG island is primarily responsible for the aberrant expression of SNCG protein in cancerous tissues. | 16140929 |
| Malignant neoplasm of ovary | Epigenetic Alterations | These data suggest that genetic and epigenetic changes might lead to elevated cytoplasmic expression of BARD1 and that cytoplasmic BARD1 might be a poor prognostic factor for breast and ovarian cancers. | 16152612 |
| Neoplasms | Epigenetic Alterations | Promoter genomic DNA methylation is an important inactivation mechanism of tumor suppressor genes. | 16163424 |
| Blood Circulation, Colorectal Cancer Pathway | Epigenetic Alterations | While promoter hypermethylation is a common molecular alteration of human colorectal cancer that could be detected in the bloodstream, we tested the feasibility of quantitative detection of aberrant DNA methylation in multiple genes in the serum samples of colorectal cancer patients. | 16181380 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The quantitative detection of aberrant DNA methylation in serum may be a promising high-throughput approach for the noninvasive screening and monitoring of colorectal cancer. | 16181380 |
| Neoplasms | Epigenetic Alterations | This observation suggested that tumors from these patients might be more prone to DNA deletion events; consistent with this, epigenetic silencing of the DNA double-strand break repair genes FancF and BRCA1 was also associated with homozygous deletion of p16(INK4a)(p = 0.002 and p = 0.06, respectively). | 16184554 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Childhood and adult ALL: differences in epigenetic lesions associated with cell cycle genes. | 16184585 |
| Arteriosclerosis, Primary malignant neoplasm | Epigenetic Alterations | Since DNA methylation is an important epigenetic factor in the regulation of gene expression, alteration of the methylation pattern has been associated with aging, cancer, atherosclerosis and other diseases. | 16197315 |
| S-Adenosylhomocysteine | Epigenetic Alterations | In conclusion, an inhibitory effect of SAH on whole-genome methylation was found, but from our data no interaction between vegetarian lifestyle and DNA methylation could be determined. | 16197315 |
| Degenerative polyarthritis | Epigenetic Alterations | This study provides the first evidence that altered synthesis of cartilage-degrading enzymes by late-stage OA chondrocytes may have resulted from epigenetic changes in the methylation status of CpG sites in the promoter regions of these enzymes. | 16200590 |
| Malignant Neoplasms, Hereditary | Epigenetic Alterations | Sporadic MSI+ cancers may require more than a single additional somatic alteration compared to hereditary MSI+ cancers because the epigenetic inactivation of MLH1 commonly observed in sporadic MSI+ cancers may be a multistep process. | 16202134 |
| ovarian neoplasm | Epigenetic Alterations | CpG island methylation of DNA damage response genes in advanced ovarian cancer. | 16204069 |
| Primary malignant neoplasm | Epigenetic Alterations | We have examined the frequency of a polymorphism in the DNA methyltransferase gene DNMT3b6, which has been previously reported to affect gene transcription and cancer risk. | 16204069 |
| Secondary malignant neoplasm of liver, Carcinogenesis, Colorectal Carcinoma | Epigenetic Alterations | In summary, we observed frequent TPEF methylation in primary colorectal cancers and liver metastases, indicating that epigenetic alterations are not only present in the early phases of carcinogenesis, but are also common in metastatic lesions. | 16207479 |
| Colorectal Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | The high frequency of TPEF methylation in this series of colorectal cancers underscores the importance of epigenetic changes as targets for the development of molecular tests for cancer diagnosis. | 16207479 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Aberrant p16 methylation, a possible epigenetic risk factor in familial esophageal squamous cell carcinoma. | 16227635 |
| Primary malignant neoplasm | Epigenetic Alterations | The inactivation of checkpoint genes by genetic and epigenetic mechanisms is frequent in all cancer types, as a less-efficient cell cycle control can lead to genetic instability and tumorigenesis. | 16230422 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia. | 16231140 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Aberrant DNA methylation was found in AML of all French-American-British subtypes and throughout all cytogenetic risk groups. | 16231140 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The growing knowledge of the role of epigenetics in the aberrant silencing of cancer-related genes provides a rationale and molecular basis for targeted therapeutic approaches with demethylating agents in AML. | 16231140 |
| Malignant - descriptor | Epigenetic Alterations | The accumulation of epigenetic events affecting genes which are involved in regulating cell cycle inhibition, cell adhesion, growth factor signaling, and apoptosis may contribute to the malignant AML phenotype. | 16231140 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers. | 16234815 |
| Primary malignant neoplasm | Epigenetic Alterations | The loss of DRM/Gremlin mRNA expression in human cancer cell lines is associated with DNA methylation, and treatment with the methylation inhibitor-reactivated mRNA expression (n=13). | 16234815 |
| PYCARD gene, Primary malignant neoplasm | Epigenetic Alterations | We checked the methylation status of 20 cancer associated genes (p14ARF, p16 CDKN2A, STAT-1, SOCS-1, DR-3, DR-6, PIG-7, BCL-2, H-TERT, BAX, EDNRB, DAPK, RASSF-1A, FADD, TMS-1, E-Cadherin, ICAM-1, TIMP-3, MLH-1, COX-2) for DNA methylation. | 16242928 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | There is increasing evidence for the role of epigenetic gene silencing in superficial bladder cancer. | 16242928 |
| Colorectal Carcinoma | Epigenetic Alterations | Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability. | 16247484 |
| Colorectal Carcinoma | Epigenetic Alterations | Mutation or epigenetic silencing of mismatch repair genes, such as MLH1 and MSH2, results in microsatellite instability (MSI) in the genome of a subset of colorectal carcinomas (CRCs). | 16247484 |
| Carcinogenesis | Epigenetic Alterations | These data indicate that epigenetic silencing of AXIN2 is specifically associated with carcinogenesis in MSI+ CRCs. | 16247484 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | DNA methylation status of CpG islands seems to be a useful predictor of long-term outcome for adenocarcinoma of the lung. | 16256792 |
| Metastasis, Neuroendocrine Tumors | Epigenetic Alterations | Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis. | 16258509 |
| Primary malignant neoplasm | Epigenetic Alterations | Since aging increases promoter hypermethylation and epigenetic silencing of HIC1, we speculate that the resultant upregulation of SIRT1 may be a double-edged sword that both promotes survival of aging cells and increases cancer risk in mammals. | 16269335 |
| Carcinogenesis | Epigenetic Alterations | Although there is growing interest in the possibility that alterations in histone methylation may play a role in carcinogenesis, it has not been explored adequately in humans. | 16276009 |
| Non-Cancer Related Death | Epigenetic Alterations | Correlations between DNA and histone methylation, H_3-Lys4 and H_3-Lys9 were positive and statistically significant in all tissue types; they were strongest in normal oral epithelium from non-cancer subjects (r=0.63, p < 0.001 and r=0.62, p < 0.001 respectively). | 16276009 |
| Carcinogenesis | Epigenetic Alterations | Patterns of DNA and histone methylation are similar in tissues across the spectrum of oral carcinogenesis, and there is a significant positive association between these two epigenetic mechanisms. | 16276009 |
| Hereditary Nonpolyposis Colorectal Cancer | Epigenetic Alterations | MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. | 16285940 |
| MLH1 gene | Epigenetic Alterations | Germline MLH1 epimutations are functionally equivalent to an inactivating mutation and produce a clinical phenotype that resembles HNPCC. | 16285940 |
| Neoplasms | Epigenetic Alterations | Germline epimutations should be suspected in younger individuals without a family history who present with a microsatellite unstable tumor showing loss of MLH1 expression. | 16285940 |
| Malignant Neoplasms | Epigenetic Alterations | Current evidence suggests that hypermethylation of promoter CpG islands is a common epigenetic event in a variety of human cancers. | 16311119 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic silencing through DNA methylation is one of the key steps during carcinogenesis. | 16314833 |
| Stomach Carcinoma | Epigenetic Alterations | Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. | 16314833 |
| HSPD1 gene | Epigenetic Alterations | Hsp60 was expressed on the plasma membrane of heat-stressed ECs, and this followed Hsp60 messenger RNA transcription, confinement of the protein to the cytoplasm, and translocation of the protein to the surface. | 16320351 |
| Colorectal Carcinoma | Epigenetic Alterations | Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries. | 16322286 |
| Prostate Cancer Pathway | Epigenetic Alterations | To analyze the prognostic significance of six epigenetic biomarkers (APC, Cyclin D2, GSTP1, TIG1, Rassf1A, and RARbeta2 promoter hypermethylation) in a homogeneous group of prostate cancer patients, following radical prostatectomy alone. | 16322291 |
| Liver Cirrhosis | Epigenetic Alterations | A comparison of CH and liver cirrhosis samples revealed significantly different pattern of miRNA expression (P<0.01). | 16331254 |
| Hollings Cancer Center | Epigenetic Alterations | Whereas three miRNAs exhibited higher expression in the HCC samples than that in the NT samples, five miRNAs demonstrated lower expression in the HCC samples than in the NT samples (P<0.0001). | 16331254 |
| Hollings Cancer Center | Epigenetic Alterations | In addition, the expression levels of four miRNAs were inversely correlated with the degree of HCC differentiation (P<0.01). | 16331254 |
| Prostate Cancer Pathway | Epigenetic Alterations | Although many genetic events have been described to be involved in androgen-dependent and/or -independent prostate cancer growth, little is known about the contribution of epigenetic events. | 16331274 |
| Hollings Cancer Center | Epigenetic Alterations | The frequent loss of transcription of p16INK4a with promoter methylation not only in the advanced but also in the early stages of HCC suggests that the epigenetic alteration of p16INK4a promoter is likely to be involved in hepatocarcinogenesis. | 16343074 |
| Stage I Esophageal Squamous Cell Carcinoma AJCC v7 | Epigenetic Alterations | Metallothionien 3 expression is frequently down-regulated in oesophageal squamous cell carcinoma by DNA methylation. | 16351731 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Given that, DNA methylation is a common event in colorectal cancer. | 16352895 |
| Neurofibromatosis 2, Meningioma | Epigenetic Alterations | Lack of genetic and epigenetic changes in meningiomas without NF2 loss. | 16353169 |
| Neurofibromatosis 2, Meningioma, Neoplasms | Epigenetic Alterations | To gain more insight into the aetiology of these tumours, we studied genetic and epigenetic alterations in 25 meningiomas without NF2 involvement. | 16353169 |
| Meningioma, Neoplasms | Epigenetic Alterations | In conclusion, meningiomas with an intact NF2 gene have a normal karyotype and no obvious genetic or epigenetic aberrations, suggesting that the gene(s) involved in the pathogenesis of these tumours are altered by smaller events than can be detected with the techniques used in our study. | 16353169 |
| Breast Cancer Cell | Epigenetic Alterations | Epigenetic mechanisms underlying tumorigenesis have recently received much attention as potential therapeutic targets of human cancer. | 16357841 |
| Blood Clot, Primary malignant neoplasm | Epigenetic Alterations | Folate deficiency is associated with increased risk for thrombosis, as well as for several types of cancer, through disruption of DNA methylation, DNA synthesis and deficient DNA repair. | 16365753 |
| melanoma, Neoplasms | Epigenetic Alterations | Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma. | 16374457 |
| melanoma, Neoplasms | Epigenetic Alterations | Our findings suggest that epigenetic silencing of the studied tumor suppressor genes is a common and probably important mechanism for melanoma formation. | 16374457 |
| Mucinous | Epigenetic Alterations | The more frequent occurrence and closer association among MSI, CIMP and BRAF mutation in mucinous CRC observed in our study further supports the idea that its pathogenesis may involve distinct genetic and epigenetic changes. | 16381005 |
| Neoplasms | Epigenetic Alterations | Tumors with BRAF mutation were also 10-fold more likely to show microsatellite instability and frequent DNA methylation (P < 0.0001) compared to tumors without this mutation. | 16403224 |
| Neoplasms | Epigenetic Alterations | In addition, downregulation of both CEP63 and EIF4G2 gene transcription was associated with invasive tumors. | 16410684 |
| Primary malignant neoplasm, Inflammation, Somatic mutation | Epigenetic Alterations | Potential molecular and physiologic contributors to the frequency of cancer occurrence in older individuals include the accumulation of somatic mutations through defects in genome maintenance, epigenetic gene silencing, oxidative stress, loss of immune surveillance, telomere dysfunction, chronic inflammation, and alterations in tissue microenvironment. | 16424011 |
| Pancreatic Diseases | Epigenetic Alterations | DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease. | 16424060 |
| Carcinogenesis | Epigenetic Alterations | DNA hypermethylation in gene promoters is an epigenetic mechanism regulating gene expression in cellular immortalization, an important step in carcinogenesis. | 16426144 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. | 16428476 |
| Bladder Neoplasm | Epigenetic Alterations | To test this hypothesis, epigenetic and genetic pathways involved in the Wif-1 gene modulation and expression of Wnt/beta-catenin-related genes were analyzed in 4 bladder tumor cell lines and 54 bladder tumor and matched normal bladder mucosa. | 16428476 |
| Carcinogenesis, Prostatic Intraepithelial Neoplasias | Epigenetic Alterations | Epigenetic heterogeneity of high-grade prostatic intraepithelial neoplasia: clues for clonal progression in prostate carcinogenesis. | 16446401 |
| Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumour suppressor genes through promoter methylation has been investigated by a variety of means, the most recent of which is pyrosequencing. | 16449996 |
| Renal Cell Carcinoma | Epigenetic Alterations | The recurrence-free survival rate of patients with RCCs showing accumulation of DNA methylation was significantly lower than that of patients not showing this feature. | 16453286 |
| Alcoholic Intoxication, Chronic | Epigenetic Alterations | Recently, it has been shown that the genomic DNA methylation in patients with alcoholism is increased. | 16463117 |
| Alcoholic Intoxication, Chronic | Epigenetic Alterations | Using a multivariate model we observed that the increase (10%) of genomic DNA methylation in patients with alcoholism was significantly associated with their lowered DNMT-3b mRNA expression (multiple linear regression, p = 0.014). | 16463117 |
| Stomach Carcinoma | Epigenetic Alterations | High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. | 16467114 |
| Carcinogenesis, Helicobacter pylori | Epigenetic Alterations | Although aberrant DNA methylation is deeply involved in gastric carcinogenesis, its induction by Helicobacter pylori, a strong gastric carcinogen, is unclear. | 16467114 |
| TMEFF2 gene | Epigenetic Alterations | Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis. | 16469793 |
| TMEFF2 gene | Epigenetic Alterations | Hyperplastic polyposis of the colorectum is a precancerous condition that has been linked with DNA methylation. | 16469793 |
| Serrated intestinal polyps, TMEFF2 gene | Epigenetic Alterations | The existence of distinguishing molecular features was explored in a series of serrated polyps and matched normal mucosa from patients with and without hyperplastic polyposis by assessing mutation of BRAF, DNA methylation in 14 markers (MINTs 1, 2 and 31, p16, MGMT, MLH1, RASSF1, RASSF2, NORE1 (RASSF5), RKIP, MST1, DAPK, FAS, and CHFR), and immunoexpression of MLH1. | 16469793 |
| TMEFF2 gene | Epigenetic Alterations | A more clearcut difference in patients with hyperplastic polyposis was the finding of extensive DNA methylation in normal mucosa from the proximal colon. | 16469793 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Accumulation of DNA methylation is associated with tumor stage in gastric cancer. | 16475210 |
| Neoplasms | Epigenetic Alterations | DNA methylation of tumor-related genes accumulates in conjunction with tumor progression. | 16475210 |
| Stomach Carcinoma | Epigenetic Alterations | DNA methylation of CHFR is not a predictor of the response to docetaxel and paclitaxel in advanced and recurrent gastric cancer. | 16475678 |
| Malignant neoplasm of kidney | Epigenetic Alterations | Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer. | 16488999 |
| Neoplasms, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Genetic and epigenetic changes in the von Hippel-Lindau (VHL) tumor suppressor gene are common in sporadic conventional renal cell carcinoma (cRCC). | 16488999 |
| Breast Carcinoma | Epigenetic Alterations | Genetic variants in epigenetic genes and breast cancer risk. | 16501248 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Epigenetic events, resulting changes in gene expression capacity, are important in tumour progression, and variation in genes involved in epigenetic mechanisms might therefore be important in cancer susceptibility. | 16501248 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | These significant SNPs were genotyped in 75 human cancer cell lines from different tumour types to assess if there was an association between them and six epigenetic measures. | 16501248 |
| Malignant neoplasm of breast | Epigenetic Alterations | Our preliminary findings suggested that abnormal CDH1 methylation occurs in high frequencies in infiltrating breast cancers associated with a decrease in E-cadherin expression in a subgroup of cases characterized by loss of expression of other important genes to the mammary carcinogenesis process, probably due to the disruption of the mechanism of maintenance of DNA methylation in tumoral cells. | 16512896 |
| Colonic Neoplasms | Epigenetic Alterations | Importantly, CIM of RASSF1A is an early epigenetic aberration, occurring in the absence of synchronous colon tumors and is not accompanied by field effects into the surrounding epithelium. | 16513682 |
| Primary malignant neoplasm | Epigenetic Alterations | The change in DNA methylation patterns can be used to distinguish between normal and cancer cells. | 16516880 |
| Stomach Carcinoma | Epigenetic Alterations | Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus. | 16518809 |
| Stomach Carcinoma | Epigenetic Alterations | CIMP status appeared to be associated with distinct genetic, epigenetic, and clinicopathologic features in gastric carcinomas. | 16518809 |
| Optic Atrophy, Hereditary, Leber | Epigenetic Alterations | It is also believed that several epigenetic factors have an influence on the development of LHON. | 16523300 |
| Neoplasms | Epigenetic Alterations | p53 wild-type is a tumor suppressor gene involved in DNA gene transcription or DNA repair mechanisms. | 16525651 |
| Hollings Cancer Center | Epigenetic Alterations | These data indicate that the epigenetic aberrance of promoter CpG island hypermethylation of the GSTP1 gene may contribute to the hepatopathogenesis of HCC and is a potential valuable biomarker for noninvasive disease monitoring and HCC early diagnosis. | 16527261 |
| Carcinoma of lung | Epigenetic Alterations | Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. | 16530703 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | miRNA expression profiles correlated with survival of lung adenocarcinomas, including those classified as disease stage I. | 16530703 |
| Carcinoma of lung | Epigenetic Alterations | These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer. | 16530703 |
| Stomach Carcinoma | Epigenetic Alterations | Hypermethylation of the CDH1 promoter region seems to be the most common epigenetic mechanism in this gene silencing in gastric cancer. | 16531765 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. | 16532500 |
| Prostatic Hyperplasia, Prostate carcinoma, Prostate Cancer Pathway | Epigenetic Alterations | These results show that the transcriptional silencing of DLC-1 by two epigenetic mechanisms is common and may be involved in the pathogenesis of prostate carcinomas and benign prostatic hyperplasias and could have potential clinical application in the early detection and gene therapy of prostate cancer. | 16533763 |
| Ductal Carcinoma | Epigenetic Alterations | The prevalence of DNA methylation of at least one of the 12 genes and the average number of methylated genes were significantly higher in both DEI (60% and 0.85 +/- 0.88, P = 0.0151 and P = 0.0224, respectively) and PanIN (67.5% and 0.95 +/- 0.85, P = 0.0014 and P = 0.0028, respectively) than in DE (15.4% and 0.15 +/- 0.38), and were further increased in ductal carcinoma (98.3% and 2.50 +/- 1.35, P < 0.0001 and P < 0.0001, respectively). | 16537562 |
| Ductal Carcinoma, Neoplasms | Epigenetic Alterations | Considerable heterogeneity of DNA methylation status was observed among multiple microdissected areas from individual ductal carcinomas, and the number of methylated genes per area was significantly correlated with poorer tumor differentiation (P = 0.0249). | 16537562 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | This is the first comprehensive study of the epigenetic dysregulation of the INK4 and CIP/KIP families of CKI in Chinese patients with CLL. | 16565223 |
| Liver carcinoma | Epigenetic Alterations | Epigenetic instability and chromosomal instability in hepatocellular carcinoma. | 16565510 |
| Hepatocarcinogenesis | Epigenetic Alterations | We found that the epigenetic instability phenotype and the chromosomal instability phenotype are not mutually exclusive in hepatocarcinogenesis and that they do not show a simple cause-and-effect relationship. | 16565510 |
| Hollings Cancer Center | Epigenetic Alterations | Furthermore, we identified an epigenetic instability-dependent HCC that shows frequent epigenetic aberrations without chromosomal instability. | 16565510 |
| Hepatocarcinogenesis, Hollings Cancer Center | Epigenetic Alterations | In summary, by combined analyses of genetic and epigenetic aberration profiles in HCC, we obtained a comprehensive view of genomic alterations in hepatocarcinogenesis. | 16565510 |
| Hollings Cancer Center | Epigenetic Alterations | These data suggest that genetic, epigenetic and environmental exposure biomarkers in plasma may help in estimating the risk for the development of HCC. | 16570275 |
| Autolysis | Epigenetic Alterations | Histone methylation differences across various genomic sites were maintained within a wide range of autolysis times and tissue pH. | 16574239 |
| Primary malignant neoplasm | Epigenetic Alterations | We thus have identified a new component of epigenetic TSG silencing that may potentially link some epigenetic changes associated with aging with those found in cancer, and provide new directions for therapeutically targeting these important genes for re-expression. | 16596166 |
| FHIT gene, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance. | 16598757 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event. | 16598760 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic changes during ageing and their relationship with cancer are under the focus of intense research. | 16606445 |
| Neoplasms, Malignant tumor of small intestine | Epigenetic Alterations | The differences in the hypermethylation spectrum of small bowel and stomach cancer indicate significant epigenetic differences between these tumors. | 16619216 |
| Parkinson Disease | Epigenetic Alterations | Transcriptional changes in multiple system atrophy and Parkinsons disease putamen. | 16626704 |
| Aplastic Anemia | Epigenetic Alterations | In conclusion, when compared with normal controls, VEGF expression decreased significantly in patients with aplastic anemia at gene transcription level and protein translation level, it may be related to the defect of angiogenesis and thus hematopoiesis in bone marrow of patients with aplastic anemia. | 16638198 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumor suppressor genes by promoter hypermethylation has been shown for a variety of genes in bladder cancer. | 16642478 |
| Liver carcinoma | Epigenetic Alterations | Decreased dietary folate in an animal model of hepatocellular carcinoma has been associated with the induction of epigenetic silencing of the p16(INK4A) gene. | 16646054 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers. | 16651412 |
| Carcinogenesis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These results suggest that epigenetic silencing by hypermethylation of the CpG-rich promoter region of PCDH20 leads to loss of PCDH20 function, which may be a factor in the carcinogenesis of NSCLC. | 16651412 |
| Malignant tumor of colon | Epigenetic Alterations | let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. | 16651716 |
| Malignant tumor of colon | Epigenetic Alterations | When let-7 low-expressing DLD-1 human colon cancer cells were transfected with let-7a-1 precursor miRNA, which is located at chromosome 9q22.3, the cells underwent significant growth suppression. | 16651716 |
| Malignant tumor of colon | Epigenetic Alterations | These findings suggest the involvement of let-7 miRNA in the growth of colon cancer cells. | 16651716 |
| Cessation of life | Epigenetic Alterations | miRNAs have been implicated in many cellular processes including cell proliferation, differentiation, and death. | 16651716 |
| Lung Neoplasms | Epigenetic Alterations | Recently, let-7 miRNAs were found to regulate human RAS oncogene expression and to be often down-regulated in human lung tumors. | 16651716 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Accordingly, deletion of the single active copy of 13q14.3 results in significant down-regulation of the candidate genes and loss of function, providing a model for the interaction of genetic lesions and epigenetic silencing at 13q14.3 in B cell chronic lymphocytic leukemia. | 16684883 |
| Neoplasms | Epigenetic Alterations | We used the high frequency and specificity of individual DNA mutations in these tumors (MSI at 17 loci) and the early timing of epigenetic events (methylation of 7 gene promoters) to investigate tumor clonality. | 16697867 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer. | 16698880 |
| Colorectal Neoplasms | Epigenetic Alterations | Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis. | 16699497 |
| Colorectal Carcinoma | Epigenetic Alterations | Most previous studies on CpG island methylation in colorectal carcinoma used methylation-specific PCR, which may detect low levels of DNA methylation with little or no biological significance. | 16699497 |
| Colorectal Neoplasms | Epigenetic Alterations | However, no study to date has quantified DNA methylation of CIMP-specific promoters in synchronous colorectal neoplasias. | 16699497 |
| Carcinoma, Adenoma, Neoplasms | Epigenetic Alterations | Utilizing real-time PCR (MethyLight), we quantified DNA methylation in five CIMP-specific gene promoters [CACNA1G (calcium channel, voltage-dependent, T type alpha-1G subunit), CDKN2A (p16/INK4A), CRABP1 (cellular retinoic acid binding protein-1), MLH1 and NEUROG1 (neurogenin 1)] and MGMT in six synchronous carcinoma pairs (12 carcinomas) and eight synchronous carcinoma and adenoma pairs (16 tumors). | 16699497 |
| Colorectal Carcinoma | Epigenetic Alterations | The CpG island methylator phenotype (CIMP) with extensive promoter methylation appears to be a distinct epigenetic subtype of colorectal carcinoma. | 16699497 |
| Colorectal Neoplasms | Epigenetic Alterations | In conclusion, epigenetic alterations at CIMP-specific promoter CpG islands in synchronous colorectal neoplasias likely have both random and nonrandom components. | 16699497 |
| Malignant neoplasm of kidney | Epigenetic Alterations | Identification of novel target genes by an epigenetic reactivation screen of renal cancer. | 16707423 |
| Childhood Leukemia | Epigenetic Alterations | DNA methylation changes after 5-aza-2-deoxycytidine therapy in patients with leukemia. | 16707479 |
| Malignant tumor of colon, Neoplasms | Epigenetic Alterations | The aberrant methylation of genes is an alternate, epigenetic mechanism for silencing tumor suppressor genes in colon cancer. | 16708352 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma. | 16708382 |
| Primary malignant neoplasm | Epigenetic Alterations | Polymorphisms in genes involved in folate metabolism may influence DNA methylation, nucleotide synthesis, and thus individual susceptibility to cancer. | 16723031 |
| Breast Cancer Cell, Premature aging syndrome | Epigenetic Alterations | Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. | 16723399 |
| Chromosomal Instability, Hypersensitivity, Primary malignant neoplasm | Epigenetic Alterations | These findings highlight the importance of WRN epigenetic inactivation in human cancer, leading to enhanced chromosomal instability and hypersensitivity to chemotherapeutic drugs. | 16723399 |
| Esophageal Diseases, Primary malignant neoplasm | Epigenetic Alterations | DNA methylation in esophageal diseases including cancer: special reference to hMLH1 gene promoter status. | 16724696 |
| Malignant Neoplasms, Prostate Cancer Pathway | Epigenetic Alterations | Overexpression of the enhancer of zeste homolog 2 (EZH2) protein, a known repressor of gene transcription, has been reported to be associated with biological malignancy of prostate cancer and several other cancers. | 16734726 |
| Neoplasms | Epigenetic Alterations | Moreover, mutations in RIS1 in MSI-H tumors correlated with the epigenetic silencing of MLH1 (P = 0.04). | 16737913 |
| Endometrial Carcinoma | Epigenetic Alterations | Epigenetic inactivation of hMLH1, CDKN2A, and MGMT may be a common and early event in the development of synchronous primary endometrial and ovarian carcinomas and may qualify as a marker of a field cancerization encompassing the ovary and endometrium. | 16740754 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Lack of MGMT protein expression is associated with aberrant promoter DNA methylation and appears to be a useful marker for predicting the survival of DLBCL patients. | 16757436 |
| Lymphoma, Non-Hodgkin | Epigenetic Alterations | Discovery of novel epigenetic markers in non-Hodgkins lymphoma. | 16774933 |
| Malignant Neoplasms, Lymphoma, Non-Hodgkin, Lymphoma, Large-Cell, Follicular | Epigenetic Alterations | Non-Hodgkins lymphoma (NHL) is a group of malignancies with heterogeneous genetic and epigenetic alterations. | 16774933 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | DNA methylation alterations in urothelial carcinoma. | 16775427 |
| melanoma | Epigenetic Alterations | Epigenetic silencing of the PTEN gene in melanoma. | 16818626 |
| melanoma, Neoplasms | Epigenetic Alterations | In summary, epigenetic PTEN silencing seems to be a relevant mechanism of inactivating this tumor suppressor gene in melanoma that may promote melanoma development by derepression of the AKT pathway. | 16818626 |
| Malignant tumor of colon, Colonic adenomas | Epigenetic Alterations | In addition, some investigators have identified an age-related increase in DNA methylation of the ESR1 locus in the colon mucosa, suggesting that DNA methylation may be a pre-neoplastic change that increases the risk of colon adenomas and colon cancer. | 16820927 |
| Malignant Neoplasms | Epigenetic Alterations | The aberrant methylation of CpG islands is a common epigenetic alteration found in cancers. | 16820927 |
| Carcinogenesis | Epigenetic Alterations | We speculate that not only genetic but also epigenetic alterations are involved in the carcinogenesis due to chromium. | 16828922 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | We analyzed P4 epigenetic alteration using methylation-specific PCR in 34 hepatocellular carcinoma (HCC) specimens, 34 matched adjacent nontumor specimens, and 8 normal adult liver specimens. | 16857788 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic silencing of functionally important genes is important in the development of malignancies and is a source of potential markers for molecular detection. | 16858686 |
| Primary central nervous system lymphoma | Epigenetic Alterations | Our study provides insight into the epigenetic alterations in PCNSL and provides potential biomarkers of disease. | 16858686 |
| Neoplasms | Epigenetic Alterations | Promoter methylation inactivates expression of some important tumor suppressor genes and may be associated with histone modification. | 16863736 |
| Aggressive behavior, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our results indicate that ASC promoter hypermethylation is a common event in patients with primary NSCLC, and this epigenetic alteration is associated with inferior survival, suggesting that ASC promoter hypermethylation might be an important biomarker for a biologic, aggressive disease in NSCLC. | 16870048 |
| Liver carcinoma | Epigenetic Alterations | Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma. | 16872311 |
| Hollings Cancer Center | Epigenetic Alterations | The results suggest that genetic and epigenetic alteration of KLF6 may play a minor role in the development of HCC. | 16872311 |
| Neoplasms | Epigenetic Alterations | However, genetic and epigenetic characteristics of these tumors were scarcely reported. | 16890591 |
| Malignant Neoplasms | Epigenetic Alterations | Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. | 16928264 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic gene silencing is one of the major causes of carcinogenesis. | 16928264 |
| Neoplasms | Epigenetic Alterations | Detection of methylation for critical loci is potentially useful as epigenetic markers in tumor classification. | 16928264 |
| Carcinogenesis | Epigenetic Alterations | By altering both DNA methylation and nucleotide synthesis, folate metabolism is thought to contribute to colorectal carcinogenesis. | 16941173 |
| Neoplasms | Epigenetic Alterations | Despite the role of DNMT3B in de novo DNA methylation, a correlation between DNMT3B expression and promoter DNA methylation has not being established in tumors. | 16951144 |
| Neoplasms | Epigenetic Alterations | An inverse correlation was found between tumor MLH1 RNA expression and MLH1 DNA methylation (P=0.003). | 16951227 |
| Stomach Carcinoma | Epigenetic Alterations | Quantitative analysis of DNA methylation using DNA microarrays is a promising method for risk assessment in the development of gastric cancer. | 16952303 |
| Malignant tumor of colon | Epigenetic Alterations | A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer. | 16952549 |
| Malignant tumor of colon | Epigenetic Alterations | To identify novel methylation targets in colon cancer, we conducted a genome-wide, microarray-based, in silico, and epigenetic search. | 16952549 |
| Primary malignant neoplasm | Epigenetic Alterations | Subsequent epigenetic analysis revealed that primary colon cancers demonstrated frequent methylation of somatostatin (SST, 30 of 34 cases, 88%) and the substance P precursor gene tachykinin-1 (TAC1; 16 of 34 cases, 47%). | 16952549 |
| Stomach Carcinoma | Epigenetic Alterations | The epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration. | 16959213 |
| Stomach Neoplasms | Epigenetic Alterations | Here, we report for the first time the epigenetic silencing of LIMS2 in gastric tumors. | 16959213 |
| Stomach Carcinoma, Metastasis, Neoplasms | Epigenetic Alterations | These results suggest that the frequent inactivation of LIMS2 by epigenetic alteration in gastric cancer may be important in tumor progression events, such as invasion and metastasis. | 16959213 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer. | 16969349 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer (CRC) develops as multistep process, which involves genetic and epigenetic alterations. | 16969349 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Progressive disease in chronic lymphocytic leukemia is correlated with the DNA methylation index. | 16970987 |
| NCI CTEP SDC Oligodendroglial Tumors Sub-Category Terminology | Epigenetic Alterations | DNA methylation and allelic losses on chromosome arm 14q in oligodendroglial tumours. | 16972885 |
| Glioma, Neoplasms | Epigenetic Alterations | In addition, the restriction of 14q32.12 methylation to oligodendroglial tumours suggests a role for epigenetic DNA modifications in these particular gliomas. | 16972885 |
| Acoustic Neuroma | Epigenetic Alterations | DNA methylation of multiple genes in vestibular schwannoma: Relationship with clinical and radiological findings. | 16983315 |
| Neoplasms | Epigenetic Alterations | The effects of epigenetic factors determining the intensity of somatic mutagenesis of p53 in tumors should be taken into account. | 16984108 |
| Neoplasms | Epigenetic Alterations | Some tumors showed concomitant APC, sFRP1 and WIF-1 gene inactivation, indicating that multiple DNA methylation events must have occurred to definitively down-regulate the signaling through Wnt. | 16991125 |
| effusion | Epigenetic Alterations | The increased E-cadherin expression in effusions may be related to lack of negative regulation at the epigenetic level. | 16996643 |
| Lymphoma, Large-Cell, Follicular, Inflammation | Epigenetic Alterations | Nutrients that affect inflammation, vitamin D activity, oxidative DNA damage, or DNA methylation may be associated with risk of NHL. | 17005624 |
| Neoplasms | Epigenetic Alterations | Celecoxib reduced angiogenesis and induced tumor transcriptional changes. | 17008411 |
| Anaplastic astrocytoma | Epigenetic Alterations | Thus, this epigenetic change is unlikely to play an important role in the evolution and development of malignant astrocytomas. | 17016577 |
| Hyperplasia | Epigenetic Alterations | We concluded that Cyclin D2 promoter methylation downregulates gene transcription and occurs with high frequency at low levels in normal, hyperplastic, and preneoplastic prostate tissues. | 17016690 |
| Primary malignant neoplasm | Epigenetic Alterations | Inactivation of cell-cycle regulating genes, such as p14ARF and p16INK4a, and cell adhesion genes, such as E-cadherin, is common in cancer, and results from genetic and/or epigenetic alterations. | 17017004 |
| Neoplasms | Epigenetic Alterations | Hypermethylation of CpG islands, caused by the action of DNA methyltransferases (DNMTs), is a major form of epigenetic inactivation of the p14ARF and p16INK4a genes in tumours. | 17017004 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | To test DNA methylation profiling in detection of urothelial carcinoma in urine. | 17017434 |
| S100A4 protein, human, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The DNA methylation paradox, manifested as derepression of cancer-testis antigens, and silencing of tumor suppressors during malignant transformation, provides the rationale for the utilization of chromatin remodeling agents for cancer therapy. | 17020984 |
| Malignant Neoplasms, Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, Neoplasms | Epigenetic Alterations | Epigenetic mechanisms involving DNA methylation and chromatin remodeling are important in silencing tumor suppressor genes (TSG) in various malignancies, including renal cell carcinoma (RCC). | 17029774 |
| Squamous cell carcinoma of skin | Epigenetic Alterations | Epigenetic abnormalities in cutaneous squamous cell carcinomas: frequent inactivation of the RB1/p16 and p53 pathways. | 17034532 |
| Carcinogenesis | Epigenetic Alterations | Our findings indicate that the promoter hypermethylation of cancer-related genes, especially CDH1, is frequently shown in SCCs, and dysregulation of the RB1/p16 and/or p53 pathway through either genetic or epigenetic mechanisms, except for epigenetic abnormalities of p53 itself, should contribute to the carcinogenesis of SCCs. | 17034532 |
| Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation of the RIZ1 gene is associated with nuclear accumulation of p53 in prostate cancer. | 17052263 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | All four PCa specimens with nuclear accumulation of p53 were stage III disease and showed DNA methylation of RIZ1. | 17052263 |
| Malignant Neoplasms | Epigenetic Alterations | However, of the remaining 43 cancers without nuclear accumulation of p53, DNA methylation of RIZ1 was observed in only 16 (37.2%) specimens (P = 0.0272). | 17052263 |
| Carcinogenesis | Epigenetic Alterations | These results suggest that transcriptional inactivation of RIZ1 by aberrant DNA methylation may contribute to prostate carcinogenesis. | 17052263 |
| Thalassemia | Epigenetic Alterations | The PXE phenotype seen in some patients with beta thalassemia appears to be associated with epigenetic modification of ABCC6 transcription and depends specifically on the beta globin locus. | 17053732 |
| Mammary Neoplasms | Epigenetic Alterations | Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours. | 17071074 |
| Breast Carcinoma | Epigenetic Alterations | We assessed expression of the BRCA1, CTCF and DNMT3b methyltransferase genes along with BRCA1 promoter methylation to better define the epigenetic events involved in BRCA1 inactivation in sporadic breast cancer. | 17071074 |
| Neoplasms, Mammary Neoplasms | Epigenetic Alterations | We suggest that these altered CTCF and DNMT3b expression patterns represent (a) critical events responsible for the epigenetic inactivation of BRCA1 and (b) a diagnostic signature for epigenetic inactivation of other tumour suppressor genes in sporadic breast tumours. | 17071074 |
| Adenocarcinoma of prostate | Epigenetic Alterations | Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. | 17071602 |
| DICER1 protein, human | Epigenetic Alterations | Dicer, an RNase III endonuclease, is an essential component of the microRNA machinery. | 17071602 |
| Adenocarcinoma of prostate | Epigenetic Alterations | Dicer up-regulation may explain an almost global increase of microRNA expression in prostate adenocarcinoma. | 17071602 |
| Adenocarcinoma of prostate | Epigenetic Alterations | The presence of up-regulated microRNA machinery may predict the susceptibility of prostate adenocarcinoma to RNA interference-based therapy. | 17071602 |
| Adenocarcinoma of prostate | Epigenetic Alterations | In prostate adenocarcinoma, 39 microRNAs are up-regulated, and six microRNAs are down-regulated. | 17071602 |
| Stomach Carcinoma | Epigenetic Alterations | Using methylated CpG island amplification coupled with representational difference analysis to identify genes inactivated by DNA methylation in gastric cancer, we identified seven DNA fragments corresponding to the 5 CpG islands of the affected genes. | 17083569 |
| Stomach Carcinoma | Epigenetic Alterations | Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. | 17083569 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic gene inactivation plays a key role in the development of various types of cancer. | 17083569 |
| Gallbladder Carcinoma, Neoplasms | Epigenetic Alterations | Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma. | 17084965 |
| Malignant Neoplasms, Cervical Intraepithelial Neoplasia | Epigenetic Alterations | These findings suggest that CIN and CIMP represent 2 independent and inversely related mechanisms of genetic and epigenetic instability in sporadic CRCs and confirm that MSI cancers arise as a consequence of CIMP. | 17087942 |
| Clinical Coordinator, Carcinogenesis, Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation plays an important role during colorectal cancer (CRC) carcinogenesis. | 17093909 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These results provide clear evidence for the prognostic significance of p16(INK4a) methylation in NSCLC using quantitative DNA methylation analysis. | 17094392 |
| Malignant tumor of colon | Epigenetic Alterations | It has been proposed that dietary factors such as folate, alcohol and methionine may be associated with colon cancer because of their involvement in DNA methylation processes. | 17096326 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Although hypermethylation was not found at the promoter region, the RhoB expression in NSCLC cell lines was induced by histone deacetylase inhibition, suggesting that RhoB downregulation may be due to histone modification. | 17096327 |
| Nasopharyngeal carcinoma, DLEC1 protein, human | Epigenetic Alterations | Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. | 17099870 |
| Malignant tumor of colon, Malignant Neoplasms | Epigenetic Alterations | The identification of novel genetic and epigenetic markers indicative of changes in the pathogenesis of colon cancer, along with easier-to-use, more sensitive assay methods, may improve the detection, treatment, and overall prognosis of this malignancy. | 17101318 |
| Fragile X Syndrome, Peroxisome Biogenesis Disorder, Complementation Group G, Mental Retardation | Epigenetic Alterations | Fragile X syndrome, the most common form of inherited mental retardation in males, arises when the normally stable 5 to 50 CGG repeats in the 5 untranslated region of the fragile X mental retardation protein 1 (FMR1) gene expand to over 200, leading to DNA methylation and silencing of the FMR1 promoter. | 17101793 |
| Skin Basal Cell Carcinoma | Epigenetic Alterations | Epigenetic silencing contributes to frequent loss of the fragile histidine triad tumour suppressor in basal cell carcinomas. | 17107382 |
| Tyrosine Transaminase Deficiency Disease, Neoplasms | Epigenetic Alterations | We have identified epigenetic silencing of the FHIT tumour suppressor gene as a frequent inactivation mechanism which is likely to contribute to functional deficiencies in DNA damage response of BCCs. | 17107382 |
| Arteriosclerosis | Epigenetic Alterations | We suggest that focal epigenetic changes in estrogen receptor beta contribute to the development of atherosclerosis and vascular aging. | 17110088 |
| Carcinogenesis, Colorectal Cancer Pathway | Epigenetic Alterations | Folate deficiency has been associated with colorectal cancer risk and may be involved in colorectal carcinogenesis through increased chromosome instability, gene mutations, and aberrant DNA methylation. | 17116713 |
| Malignant Neoplasms | Epigenetic Alterations | It is possible that deregulation of miRNA may contribute to the oncogenesis of some cancers. | 17121874 |
| Primary malignant neoplasm | Epigenetic Alterations | Little is known about the role of miRNAs in normal and cancer cells. | 17121874 |
| Esophageal Neoplasms, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Reprimo methylation occurs significantly more frequently in BE, HGD, and EAC than in NE or ESCC, suggesting that this epigenetic alteration is a specialized columnar, cell-specific early event with potential as a biomarker for the early detection of esophageal neoplasia. | 17121882 |
| Liver carcinoma | Epigenetic Alterations | Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma. | 17121887 |
| Adenoma, Neoplasms | Epigenetic Alterations | Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas. | 17143260 |
| Neoplasms | Epigenetic Alterations | However, the accurate frequencies of genetic and epigenetic alterations in flat-type colorectal advanced adenomas (laterally spreading tumors) have remained largely unknown. | 17143260 |
| Adenoma | Epigenetic Alterations | Epigenetic alterations infrequently occurred in flat-type advanced adenomas, suggesting that they have different genetic and epigenetic alterations from those of protruded-type advanced adenomas. | 17143260 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | This is the first report showing that M score analysis of Wnt antagonist genes can serve as an excellent epigenetic biomarker panel for detection, staging, and prognosis of RCC using serum DNA. | 17145819 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia. | 17148581 |
| Prostate Cancer Pathway, Prostatic Intraepithelial Neoplasias | Epigenetic Alterations | DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation. | 17164146 |
| Initiation, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our results demonstrate that 15-LO-1 promoter methylation is frequently present in PCa patients and identify a new role for epigenetic phenomenon in PCa wherein hypermethylation of the 15-LO-1 promoter leads to the upregulation of 15-LO-1 expression and enzyme activity contributes to PCa initiation and progression. | 17164146 |
| Colorectal Carcinoma | Epigenetic Alterations | Colorectal cancers are characterized by genetic and epigenetic alterations. | 17167178 |
| Colorectal Carcinoma, Colorectal Neoplasms | Epigenetic Alterations | Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers. | 17183069 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation and histone deacetylation participate in cancer development and progression; hence, their reversal by inhibitors of DNA methylation and histone deacetylases (HDACs) is at present undergoing clinical testing in cancer therapy. | 17183730 |
| Colorectal Carcinoma, Neoplasm Metastasis | Epigenetic Alterations | In a gene evaluation set consisting of sera from 24 patients with local colorectal cancers, 14 with metastasized disease, and 20 healthy controls, the genes HPP1/TPEF, HLTF, and hMLH1 were identified as potential serum DNA methylation markers. | 17189406 |
| Primary malignant neoplasm | Epigenetic Alterations | It is well known that epigenetic alterations such as DNA methylation of CpG dinucleotides located in CpG islands within the regulatory (promoter) regions of genes are associated with transcriptional silencing in cancer. | 17192040 |
| Neoplasms | Epigenetic Alterations | We could assess the DNA methylation status of an average of 2,012 CpG islands for each tumor. | 17192040 |
| Lung Neoplasms | Epigenetic Alterations | Among 162 sites of differential DNA methylation, detected from at least one tumor/normal pair, 21 hypermethylated genes were identified that were not reported previously as hypermethylated in lung tumor tissue. | 17192040 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | However, DNA methylation markers that are highly specific and sensitive for common tumors would be useful for the early detection of cancer, and those required for the malignant phenotype would identify pathways important as therapeutic targets. | 17194187 |
| Carcinoma of lung | Epigenetic Alterations | The epigenetic inactivation of genes plays an important role in lung cancer. | 17196704 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our results show that the hypermethylation frequency of single genes and the accumulation of epigenetic alterations in individual samples of NSCLC patients may vary considerably. | 17196704 |
| Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation has been shown to play important roles during multistage carcinogenesis in various human organs. | 17196739 |
| Pancreatic carcinoma | Epigenetic Alterations | These preliminary observations suggest that plasma DNA might be a useful surrogate in detecting genetic and epigenetic alterations of pancreatic cancer. | 17198183 |
| Pancreatic carcinoma | Epigenetic Alterations | Further studies on environmental modulators of epigenetic changes in pancreatic cancer are warranted. | 17198183 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Folate deficiency has been implicated in the etiology of stomach cancer through abnormal DNA methylation and disrupted DNA synthesis and repair. | 17220339 |
| Endometrial Carcinoma | Epigenetic Alterations | Epigenetic silencing of MLH1 is the most common cause of defective DNA mismatch repair in endometrial and colorectal cancers. | 17230510 |
| Malignant Neoplasms | Epigenetic Alterations | Identification of risk alleles for MLH1 methylation could shed light on mechanisms of epigenetic silencing and may ultimately lead to new approaches to the prevention or treatment of malignancies associated with MLH1 inactivation. | 17230510 |
| Malignant neoplasm of pancreas, Adenocarcinoma of pancreas | Epigenetic Alterations | SPARC undergoes epigenetic silencing in many pancreatic cancers, but stromal fibroblasts adjacent to infiltrating pancreatic adenocarcinomas frequently express SPARC. | 17235047 |
| Neoplasms | Epigenetic Alterations | The objective of this study was to develop a reliable, clinically validated assay for detection of epigenetic silencing of the MGMT gene using formalin-fixed, paraffin-embedded brain tumor resections and methylation-specific PCR. | 17260000 |
| Neoplasms | Epigenetic Alterations | Thirteen genes were analyzed for DNA methylation: the pro-apoptotic CASP8, CASP3, CASP9, DcR1, DR4, DR5 and TMS1; the cell adherence CDH1 and CDH13; the candidate tumor suppressor RASSF1A and BLU; the cell cycle regulator CHFR and the DNA repair MGMT. | 17272309 |
| Neoplasms | Epigenetic Alterations | The CpG island promoter hypermethylation profile of relapsed GBM in comparison with their corresponding primary tumors was identical in 37.5% of the cases, whereas in 62.5% of patients, differences in the DNA methylation patterns of the 13 genes were observed. | 17272309 |
| Lynch Syndrome | Epigenetic Alterations | Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas. | 17278092 |
| Clinical Coordinator, Hereditary Malignant Neoplasm | Epigenetic Alterations | The role of epigenetic alterations, such as aberrant DNA methylation, in the polyp-cancer sequence in sporadic CRC and particularly in hereditary colon cancer is not well understood. | 17278092 |
| Adenoma, Clinical Coordinator, polyps, Lynch Syndrome, Malignant tumor of colon | Epigenetic Alterations | Consequently, we assessed the methylation status of CDKN2A/p16, MGMT, MLH1 and p14(ARF) in adenomas arising in the Lynch syndrome, a familial colon cancer syndrome caused by MLH1 and MSH2 mutations, to determine if DNA methylation is a "second hit" mechanism in CRC and to characterize the role of DNA methylation in the polyp phase of the Lynch syndrome. | 17278092 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer (CRC) forms through a series of histologic steps that are accompanied by mutations and epigenetic alterations, which is called the polyp-cancer sequence. | 17278092 |
| Squamous cell carcinoma | Epigenetic Alterations | Human papillomavirus-16 DNA methylation patterns support a causal association of the virus with oral squamous cell carcinomas. | 17278110 |
| precancerous lesions, Malignant Lesion, Infection | Epigenetic Alterations | Our previous investigations of HPV-16 DNA methylation in anogenital sites have identified hypermethylation of the L1 gene and part of the long control region in many malignant lesions, but rarely in asymptomatic infections and low-grade precancerous lesions. | 17278110 |
| Oral Cavity Carcinoma, Carcinoma, Malignant Lesion | Epigenetic Alterations | These data indicate epigenetic changes of HPV-16 in oral carcinomas similar to those in anogenital carcinomas, suggesting carcinogenic processes under the influence of HPV-16 in most if not all of these oral malignant lesions. | 17278110 |
| Carcinogenesis | Epigenetic Alterations | Accumulating evidence implicates epigenetic changes such as hypermethylation in carcinogenesis. | 17285579 |
| Hepatocarcinogenesis, Hollings Cancer Center, Liver carcinoma | Epigenetic Alterations | To gain insight into the role of epigenetic aberration of tumor-related genes in hepatocarcinogenesis, we determined a hypermethylation profile in hepatocellular carcinoma (HCC). | 17289889 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The epigenetic regulation of the PDGF-B gene dictates whether TGFbeta acts as an oncogenic factor inducing PDGF-B and proliferation in human glioma. | 17292826 |
| Malignant tumor of colon | Epigenetic Alterations | APC mutations and other genetic and epigenetic changes in colon cancer. | 17293392 |
| Malignant tumor of colon | Epigenetic Alterations | The relationships of APC mutations to other genetic and epigenetic alterations add to the already impressive genetic heterogeneity of colon cancer. | 17293392 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Genetic and epigenetic analysis of the EPHB2 gene in gastric cancers. | 17295683 |
| Stomach Carcinoma, Malignant neoplasm of stomach | Epigenetic Alterations | A search was made for mutations at the A9 tract in exon 17, an allelic loss at the EPHB2 gene locus, and promoter hypermethylation of the EPHB2 gene in 81 sporadic gastric cancers in order to determine if genetic or epigenetic alterations of the EPHB2 gene are involved in the development and/or progression of gastric cancer. | 17295683 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Therefore, genetic or epigenetic alterations of the EPHB2 gene might be an uncommon event in the development or progression of gastric cancers. | 17295683 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Methylation of the promoter region of tumor suppressor genes is increasingly recognized to play a role in cancer development through silencing of gene transcription. | 17301267 |
| Hereditary Nonpolyposis Colorectal Cancer, Primary malignant neoplasm | Epigenetic Alterations | Persons who have hypermethylation of one allele of MLH1 in somatic cells throughout the body (a germ-line epimutation) have a predisposition for the development of cancer in a pattern typical of hereditary nonpolyposis colorectal cancer. | 17301300 |
| Primary malignant neoplasm | Epigenetic Alterations | These findings demonstrate a novel pattern of inheritance of cancer susceptibility and are consistent with transgenerational epigenetic inheritance. | 17301300 |
| ovarian neoplasm | Epigenetic Alterations | Epigenetic silencing of HSulf-1 in ovarian cancer:implications in chemoresistance. | 17310998 |
| ovarian neoplasm | Epigenetic Alterations | Collectively, these data indicate that HSulf-1 is epigenetically silenced in ovarian cancer and that epigenetic therapy targeting HSulf-1 might sensitize ovarian tumors to conventional first-line therapies. | 17310998 |
| malignant disease, Neoplasms | Epigenetic Alterations | Accumulating evidence suggests that MMP promoter single nucleotide polymorphisms (SNPs) effecting gene transcription are associated with enhanced susceptibility for the development of malignant disease, increased tumour invasiveness and poor patient survival. | 17311017 |
| oligodendroglioma, Neoplasms | Epigenetic Alterations | Because little is known about the evolution of genetic and epigenetic changes that occur during tumor progression in oligodendrogliomas, we evaluated these changes in paired early and progressive oligodendrogliomas. | 17332285 |
| Clinical Coordinator, precancerous lesions | Epigenetic Alterations | Methylation testing of fecal DNA using a panel of epigenetic markers may be a simple and promising non-invasive screening method for CRC and precancerous lesions. | 17352030 |
| Mouse mammary tumor virus, CXCL14 gene, Neoplasms | Epigenetic Alterations | Oncogenic wingless-related mouse mammary tumour virus (Wnt) signalling, caused by epigenetic inactivation of specific pathway regulators like the putative tumour suppressor secreted frizzled-related protein 1 (SFRP1), may be causally involved in the carcinogenesis of many human solid tumours including breast, colon and kidney cancer. | 17353908 |
| Cervical Adenocarcinoma | Epigenetic Alterations | Although the incidence of cervical adenocarcinoma is increasing, few genetic and epigenetic changes in its progression have been described. | 17360030 |
| Squamous cell carcinoma, Adenocarcinoma | Epigenetic Alterations | Different genetic/epigenetic alterations may explain the possible different therapeutic responsiveness between adenocarcinoma and squamous cell carcinoma of uterine cervix seen in clinic. | 17360030 |
| Neoplasms | Epigenetic Alterations | Our data suggest that gene mutation and/or epigenetic events that cannot be detected by assay of gross alteration of chromosomal structure are likely to underlie the malignant transformation events of this tumor type. | 17372589 |
| Colorectal Carcinoma | Epigenetic Alterations | Utilizing real-time polymerase chain reaction (PCR; MethyLight technology), we quantified DNA methylation in 13 CpG island loci (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3, SOCS1, MINT1, MINT31, IGFBP3, MGMT, and WRN) in 30 metastatic microsatellite stable colorectal carcinomas in phase I/II clinical trials of combination chemotherapy (5-fluorouracil, irinotecan, leucovorin, and gefitinib). | 17372756 |
| Colorectal Carcinoma | Epigenetic Alterations | The CpG island methylator phenotype (CIMP) is a distinct epigenetic phenotype in colorectal carcinoma with concordant methylation in multiple promoter CpG islands. | 17372756 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Dietary folate status appears to influence risk for colorectal cancer possibly by alterations in DNA methylation and nucleotide precursor pools. | 17372834 |
| Adenoma of large intestine | Epigenetic Alterations | We sought to determine the association between folate status, folate metabolism, DNA methylation, tobacco, alcohol consumption, and the risk of colorectal adenomas in African Americans. | 17372834 |
| Colorectal Neoplasms | Epigenetic Alterations | Our results contribute to the hypothesis that altered DNA methylation and methyl metabolism is associated with colorectal neoplasia. | 17375119 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic mechanisms such as DNA methylation play important role in cancer. | 17383681 |
| Neoplasms | Epigenetic Alterations | There was concordance between DNA methylation in tumor and paired serum DNA of each gene. | 17383681 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic alterations involved in the onset and progression of breast cancer may serve as biomarkers for early detection and prediction of disease prognosis. | 17383681 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer. | 17388669 |
| Carcinoma of lung | Epigenetic Alterations | We performed restriction landmark genomic scanning on 40 patient samples and identified 47 DNA methylation targets that together could distinguish the two lung cancer subgroups. | 17388669 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | DNA demethylating agents are used to reverse epigenetic silencing of tumor suppressors in cancer therapeutics. | 17389721 |
| Neoplasms | Epigenetic Alterations | Epigenetic predictive models developed using artificial intelligence techniques identified the presence and timing of tumor progression with 97% specificity and 75% sensitivity. | 17404085 |
| Ulcerative Colitis, Dysplasia | Epigenetic Alterations | Given that both genetic and epigenetic changes are common in UC mucosa and dysplasias, we speculate that the genetic changes lead to a more aggressive clinical course than epigenetic changes. | 17408633 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer. | 17415710 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Clonogenic acute myelogenous leukemia cells are heterogeneous with regard to regulation of differentiation and effect of epigenetic pharmacological targeting. | 17416413 |
| Prostate Cancer Pathway | Epigenetic Alterations | Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis. | 17437806 |
| Stomach Carcinoma | Epigenetic Alterations | Risk prediction of gastric cancer by analysis of aberrant DNA methylation in non-neoplastic gastric epithelium. | 17438355 |
| Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation is one of the major events in carcinogenesis. | 17438355 |
| Stomach Carcinoma, Infection caused by Helicobacter pylori | Epigenetic Alterations | We aimed to clarify the relationship of aberrant DNA methylation in non-neoplastic gastric epithelia with the risk of gastric cancer, Helicobactor pylori infection, and the degree of H. pylori-induced gastritis. | 17438355 |
| Stomach Carcinoma, Peptic Ulcer, Gastritis | Epigenetic Alterations | The status of aberrant DNA methylation was compared in two groups of patients: 43 cases with gastric cancer (mean age 65.9 years [29-91], F:M = 0.30, intestinal type [n = 25], diffuse type [n = 18]) and 46 age- and sex-matched patients without gastric cancer (peptic ulcer diseases [n = 11], gastritis [n = 35]) as a control group. | 17438355 |
| Thyroid Lymphoma | Epigenetic Alterations | HLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese. | 17454594 |
| Prostate Cancer Pathway | Epigenetic Alterations | This is the first report suggesting that reduced histone acetylation or H3K4me2 methylation and increased dimethyl-H3-K9 methylation play a critical role in the maintenance of promoter DNA methylation-associated RASSF1A gene silencing in prostate cancer. | 17473182 |
| Prostate Cancer Pathway | Epigenetic Alterations | Epigenetic modifications of RASSF1A gene through chromatin remodeling in prostate cancer. | 17473182 |
| Stomach Carcinoma | Epigenetic Alterations | Gastric carcinoma is characterised by numerous genetic and epigenetic alterations that influence cell cycle progression, apoptosis and DNA repair. | 17483253 |
| Colorectal Neoplasms | Epigenetic Alterations | Epigenetic alterations have been reported in colorectal neoplasia which can either complement or in some cases be predisposed to genetic alterations such as K-ras mutations. | 17487400 |
| Carcinogenesis | Epigenetic Alterations | These findings strongly support the hypothesis that epigenetic mechanisms play an important role in the early steps of colorectal carcinogenesis. | 17487400 |
| Degenerative polyarthritis | Epigenetic Alterations | Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. | 17502362 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | These data suggest that the decrease in Shp1 in advanced stage CML patients is due to post-transcriptional modifications. | 17503411 |
| Morphologically abnormal structure (morphologic abnormality) | Epigenetic Alterations | The anomaly persisted in lymphocytes cultured for 48 h. There was no evidence of abnormal DNA methylation, a major feature of constitutive heterochromatin and associated with the loss of its structure. | 17503660 |
| Infection caused by Helicobacter pylori | Epigenetic Alterations | Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication. | 17509026 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | We analyzed epigenetic silencing of 16 genes in a population-based incident case series of 331 bladder transitional cell carcinomas. | 17522068 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | This work, studying all stages and grades of incident bladder cancer, provides definitive evidence that carcinogen exposures play a critical role in selecting these alterations in tumorous clones and that epigenetic silencing is a strong and significant predictor of tumor stage and overall patient survival. | 17522068 |
| Glioma | Epigenetic Alterations | Epigenetic inactivation of the hMLH1 gene in progression of gliomas. | 17525680 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population. | 17532092 |
| Hepatitis B, Liver carcinoma | Epigenetic Alterations | Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma. | 17534893 |
| Hepatobiliary Disorder | Epigenetic Alterations | In conclusion, aberrant DNA methylation may begin at different stages of liver disease in a gene-dependent manner. | 17534893 |
| melanoma | Epigenetic Alterations | Genetic and epigenetic alterations in the differential diagnosis of malignant melanoma and spitzoid lesion. | 17535228 |
| Neoplasms | Epigenetic Alterations | These results show that, although most atypical Spitz tumours do not differ from conventional Spitz naevi showing virtually no genetic and epigenetic aberrations, some cases may have chromosomal aberrations that include copy number loss of the CDKN2A gene. | 17535228 |
| Epithelioid and spindle cell nevus, melanoma, Neoplasms | Epigenetic Alterations | Genetic and epigenetic analyses may be useful as an additional diagnostic tool to distinguish between melanoma and Spitz naevus, and may help to define subgroups in atypical Spitz tumours. | 17535228 |
| Mammary Neoplasms | Epigenetic Alterations | Abnormalities in X chromosome copy number and in the epigenetic stability of the inactive X chromosome (Xi) have been proposed to characterize BRCA1 breast tumors. | 17545591 |
| Neoplasms | Epigenetic Alterations | However, our data suggest that amplifications or mutations of this gene seldom occur in HNSCC and that epigenetic events can play an important role in advanced tumour stages. | 17549376 |
| Malignant neoplasm of lung | Epigenetic Alterations | Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers. | 17549418 |
| Multiple Myeloma | Epigenetic Alterations | Epigenetic dysregulation of the death-associated protein kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma. | 17557868 |
| Primary malignant neoplasm | Epigenetic Alterations | Dysregulation of normal promoter usage has been shown to occur in cancer; DNA methylation regulates promoter use. | 17569086 |
| ovarian neoplasm | Epigenetic Alterations | Thus, we sought to examine if DNA methylation varies among IGF-II promoters in ovarian cancer and if methylation patterns are related to clinical features of the disease. | 17569086 |
| Primary malignant neoplasm, Cessation of life | Epigenetic Alterations | From these findings, we propose that EGCG is effective in causing cell death in both MCF-7 and HL60 cancer cell lines and may work through different pathways involving both anti-oxidant effects and epigenetic modulation. | 17570133 |
| Carcinoma | Epigenetic Alterations | MLH1 HM was found in approximately 16% of polyps found in young patients and represents one of the epigenetic changes that may result in the subsequent progression to carcinoma along an accelerated sequence. | 17573746 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | DNA methylation profiling of myelodysplastic syndrome hematopoietic progenitor cells during in vitro lineage-specific differentiation. | 17577921 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Deregulated epigenetic mechanisms are likely involved in the pathogenesis of myelodysplastic syndromes (MDSs). | 17577921 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Neoplasms | Epigenetic Alterations | Epigenetic changes have been implicated in the pathogenesis of solid tumors, including head and neck squamous cell carcinoma (HNSCC). | 17582607 |
| Squamous intraepithelial lesion | Epigenetic Alterations | Human papillomavirus DNA integration and messenger RNA transcription in cervical low- and high-risk squamous intraepithelial lesions in Austrian women. | 17587315 |
| Malignant Head and Neck Neoplasm, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Promoter hypermethylation of tumor suppressor genes is common in head and neck cancer as well as other primary cancers resulting in epigenetic gene silencing. | 17592394 |
| Neoplasms | Epigenetic Alterations | Significant association was observed between ERalpha and PRB methylation (p< or =0.001) and there was concordance between DNA methylation in tumor and serum for each gene. | 17599361 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | This study also underscores the potential utility of DNA methylation based screening of serum (a surrogate for tumor DNA methylation) as a tool for detection of breast cancer. | 17599361 |
| Breast Carcinoma, European Organization for Research and Treatment of Cancer, tamoxifen, Primary malignant neoplasm | Epigenetic Alterations | DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group. | 17601725 |
| Breast Carcinoma | Epigenetic Alterations | Our aim was to identify and validate DNA-methylation markers associated with very good outcome in node negative, hormone receptor positive breast cancer patients after adjuvant endocrine therapy which might allow identifying patients who could be spared the burden of adjuvant chemotherapy. | 17601725 |
| Colorectal Neoplasms | Epigenetic Alterations | Little is known about epigenetic alterations in laterally spreading colorectal tumors (LSTs). | 17620311 |
| Colorectal Carcinoma | Epigenetic Alterations | Utilizing real-time polymerase chain reaction (MethyLight technology), we quantified DNA methylation in MGMT and eight other markers (a CIMP diagnostic panel including CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1 in 182 colorectal cancers collected from two prospective cohorts, the Nurses Health Study and the Health Professionals Follow-up Study. | 17621591 |
| Carcinogenesis | Epigenetic Alterations | The epigenetics of ovarian carcinogenesis remains poorly described. | 17623056 |
| Recurrent respiratory papillomatosis | Epigenetic Alterations | To investigate the contribution of promoter methylation-mediated epigenetic events in recurrent respiratory papillomatosis tumorigenesis. | 17638782 |
| Recurrent respiratory papillomatosis | Epigenetic Alterations | A clonal origin was derived for 5 of 15 recurrent respiratory papillomatosis biopsy specimens based on identical epigenetic events. | 17638782 |
| Recurrent respiratory papillomatosis, Neoplasms | Epigenetic Alterations | The high frequency of epigenetic events, characterized by consistent promoter hypermethylation of multiple tumor suppressor genes, points to the use of gene silencing mechanisms in the pathogenesis of recurrent respiratory papillomatosis. | 17638782 |
| Clinical Coordinator, Colorectal Cancer Pathway, Adenoma | Epigenetic Alterations | DNA methylation of secreted frizzled-related proteins (SFRPs) can be detected in colorectal cancer (CRC) tissue, in tissue of adenomas, and in aberrant crypt foci, whereas in normal colorectal mucosa tissue, SFRP genes are unmethylated. | 17639423 |
| Prostate Cancer Pathway | Epigenetic Alterations | This is the first report showing that CYP7B1 is overexpressed in high-grade PIN and in prostate cancer and that local methylation of CYP7B1 promoter region may have significant effect on gene transcription. | 17639508 |
| Malignant mesothelioma | Epigenetic Alterations | DNA methylation profile of 28 potential marker loci in malignant mesothelioma. | 17659810 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation changes in cancer cells provide powerful markers that are potentially detectable non-invasively in DNA shed into bodily fluids. | 17659810 |
| Agenesis of corpus callosum | Epigenetic Alterations | These coexistent mutations/epigenetic inactivations in PI3K/AKT pathway may be responsible for the unusually aggressive course of ACC. | 17669465 |
| Neoplasms | Epigenetic Alterations | The E-cadherin gene methylation presence in tumors with lowest invasive and metastatic potential, such as VC, suggests the early involvement of this epigenetic event in the multistep progression of the oral carcinogenesis. | 17685455 |
| Ameloblastoma | Epigenetic Alterations | [DNA methylation of human telomerase reverse transcriptase promoter region in human ameloblastoma]. | 17686286 |
| Malignant Neoplasms | Epigenetic Alterations | The IHC findings in MSI-H cancers with methylation in distal or both regions of MLH1 promoter have not confirmed the epigenetic silencing of the MLH1 gene. | 17688369 |
| Malignant Neoplasms | Epigenetic Alterations | The polycomb group protein Enhancer of Zeste Homolg 2 (EZH2), a repressor of gene transcription, has been linked to the progression of various malignancies. | 17694325 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Many cadherins (CDH) are associated with various types of cancer and their genetic and epigenetic alterations might be involved in carcinogenesis. | 17695513 |
| Hodgkin Disease, Huntington Disease | Epigenetic Alterations | Transcriptional dysregulation in Huntingtons disease (HD) is mediated in part by aberrant patterns of histone acetylation. | 17702032 |
| Heart Diseases | Epigenetic Alterations | Altered microRNA expression in human heart disease. | 17712037 |
| Heart Diseases | Epigenetic Alterations | These data show that expression of many microRNAs is altered in heart disease and that different types of heart disease are associated with distinct changes in microRNA expression. | 17712037 |
| Colorectal Cancer Pathway | Epigenetic Alterations | mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer. | 17716371 |
| Malignant tumor of colon, High-Frequency Microsatellite Instability | Epigenetic Alterations | Based on combined miRNA and mRNA gene expression, a molecular signature consisting of twenty seven differentially expressed genes, inclusive of 8 miRNAs, could correctly distinguish MSI-H versus MSS colon cancer samples. | 17716371 |
| Microsatellite instability-high colorectal cancer | Epigenetic Alterations | This is the first report that indicates the existence of differences in miRNA expression between MSS versus MSI-H colorectal cancers. | 17716371 |
| Breast Cancer Cell | Epigenetic Alterations | In addition, the work suggests that the combination of mRNA/miRNA expression signatures may represent a general approach for improving bio-molecular classification of human cancer. | 17716371 |
| Malignant Neoplasms | Epigenetic Alterations | Among the differentially expressed miRNAs, various members of the oncogenic miR-17-92 family were significantly up-regulated in MSS cancers. | 17716371 |
| Malignant neoplasm of gastrointestinal tract | Epigenetic Alterations | Our aim was to clarify the expression profiles and epigenetic alterations of the HHIP gene in gastrointestinal cancer. | 17724792 |
| Primary malignant neoplasm, Malignant neoplasm of gastrointestinal tract | Epigenetic Alterations | The expression and promoter epigenetic status of HHIP in cancer cell lines and freshly resected gastrointestinal cancer tissues were examined using RT-PCR, tissue microarray analysis, methylation-specific PCR, and chromatin immunoprecipitation assay. | 17724792 |
| Parkinson Disease | Epigenetic Alterations | We identified a miRNA, miR-133b, that is specifically expressed in midbrain DNs and is deficient in midbrain tissue from patients with Parkinsons disease. | 17761882 |
| Malignant neoplasm of breast | Epigenetic Alterations | Aberrant DNA methylation has been found frequently in human breast cancers, associated with the loss of expression of a number of regulatory genes for growth and correlated to clinical outcomes. | 17764565 |
| Malignant Neoplasms, Primary Neoplasm | Epigenetic Alterations | This study examines whether gene-promoter hypermethylation could be detected in HNSCC surgical margins with no histologic evidence of malignancy, and if so, whether it reflects epigenetic events of primary tumors. | 17785562 |
| Malignant Neoplasms | Epigenetic Alterations | 14-3-3 sigma has been a major G2/M checkpoint control gene and has demonstrated that its inactivation in various cancers occurs mostly by epigenetic hypermethylation, not by genetic change. | 17786341 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic silencing of MGMT function by its promoter hypermethylation is considered to contribute to carcinogenesis. | 17825378 |
| Breast Carcinoma | Epigenetic Alterations | Except for inherited forms of breast cancer, however, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior. | 17850661 |
| Breast Carcinoma | Epigenetic Alterations | These findings suggest that epigenetic transcriptome changes, more than genotypic variation, account for age-associated differences in sporadic breast cancer incidence and prognosis. | 17850661 |
| Neoplasms, Lymphoma | Epigenetic Alterations | Aberrant hypermethylation of CpG islands in the promoter region of tumor suppressor and other important genes in neoplastic cells of lymphoma has been demonstrated to be one of the mechanisms for epigenetic loss of gene function. | 17852707 |
| Carcinoma of lung | Epigenetic Alterations | These results suggest that the attenuated function of SIN3A due to a decreased level of expression may result in epigenetic de-regulation of growth-related genes through histone acetylation, which leads to the tumorigenesis of lung cancer cells. | 17854949 |
| Breast Carcinoma | Epigenetic Alterations | Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer risk. | 17855699 |
| Germ-Line Mutation, Hereditary Nonpolyposis Colorectal Cancer, Lynch Syndrome, Neoplasms | Epigenetic Alterations | Some of the tumours are caused by hereditary mutations (hereditary nonpolyposis colon cancer or Lynch syndrome), but most are epigenetic changes of sporadic origin. | 17868408 |
| Breast Carcinoma | Epigenetic Alterations | We recently found that DNA methylation of S100A2, spleen tyrosine kinase (SYK), and Stathmin-1 (STMN1) correlates with response to tamoxifen therapy in metastatic breast cancer. | 17874182 |
| Primary malignant neoplasm | Epigenetic Alterations | The isolated cultures may provide a useful in vitro model to elucidate epigenetic effects on angiogenesis in cancer and to optimize antiangiogenic therapy. | 17876298 |
| Multiple Myeloma | Epigenetic Alterations | Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma. | 17882284 |
| Stomach Carcinoma | Epigenetic Alterations | The presence of high levels of aberrant DNA methylation in gastric mucosae correlates with risk of gastric cancer. | 17900260 |
| Lymphoma, Follicular | Epigenetic Alterations | Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular lymphoma. | 17900658 |
| Lymphoma, Follicular, Mantle cell lymphoma | Epigenetic Alterations | In summary, most patients with mantle cell lymphoma and follicular lymphoma had epigenetic aberrations targeting the INK4/Rb pathway. | 17900658 |
| Carcinoma of lung | Epigenetic Alterations | Epigenetic inactivation of genes by promoter hypermethylation, a major mechanism in the initiation and progression of tobacco-induced cancer, has also been associated with lung cancer induced through environmental and occupational exposures. | 17903034 |
| Tetranitromethane, Neoplasms | Epigenetic Alterations | The RPA classified the patients into seven distinct prognostic groups based on TNM stage (first node), histology, and histone modifications: H3K4diMe (< or 85% tumor cells), H3K9Ac (< or 68% tumor cells), and H2AK5Ac (< or 5% tumor cells). | 17906200 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic modifications may contribute to the development and progression of cancer. | 17906200 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The prognostic influence of epigenetic changes involving multiple histones, in particular H2A and H3, is greater in early NSCLC, and evaluation of these changes may help in selecting early-stage NSCLC patients for adjuvant treatment. | 17906200 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Impaired TNFalpha-induced VEGF expression in human airway smooth muscle cells from smokers with COPD: role of MAPkinases and histone acetylation--effect of dexamethasone. | 17906365 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | VEGF expression is directly modulated by phosphorylation of ERK-1,-2 and p38MAPK and by histone acetylation and the acetylation status of the VEGF gene is increased in HASMC of smokers with COPD in a smoking-independent manner. | 17906365 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer. | 17909015 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Long-range epigenetic silencing of contiguous genes has been found on chromosome 2q14 in colorectal cancer. | 17909015 |
| Colorectal Carcinoma | Epigenetic Alterations | Our results show that coordinate epigenetic silencing extends across a large chromosomal region encompassing MLH1 in microsatellite-unstable colorectal cancers. | 17909015 |
| Primary malignant neoplasm | Epigenetic Alterations | Simultaneous epigenetic silencing of this cluster of 3p22 genes may contribute to the development or progression of this type of cancer. | 17909015 |
| Unknown (origin) (qualifier value), Lupus Erythematosus | Epigenetic Alterations | These results suggest that defective T cell PKCdelta activation may contribute to the development of idiopathic and hydralazine-induced lupus through effects on T cell DNA methylation. | 17911642 |
| Carcinoma of lung | Epigenetic Alterations | Genetic and environmental factors (dietary and smoking) influence lung cancer epidemiology and induce epigenetic modifications that should be assessed in individual populations. | 17923809 |
| Colorectal Neoplasms, Neoplasms | Epigenetic Alterations | Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features. | 17923875 |
| MAGEC2 gene | Epigenetic Alterations | Inducible expression of a prostate cancer-testis antigen, SSX-2, following treatment with a DNA methylation inhibitor. | 17929270 |
| Prostate Cancer Pathway | Epigenetic Alterations | In addition, we report that the treatment of at least two human prostate cancer cell lines with the DNA methylation inhibitor 5-aza-2-deoxycytidine induced the expression of SSX-2. | 17929270 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy. | 17947473 |
| Carcinoma of lung | Epigenetic Alterations | The epigenetic inactivation of certain genes by aberrant promoter methylation plays an important role in the pathogenesis of lung cancer. | 17960794 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | PITX2 DNA-methylation was measured in tumor tissue from 412 LNN/HR+ breast cancer patients who had not received any adjuvant systemic treatment. | 17965955 |
| Breast Carcinoma | Epigenetic Alterations | In addition, PITX2 DNA-methylation and mRNA expression was evaluated in 32 breast cancer cell lines. | 17965955 |
| Breast Carcinoma | Epigenetic Alterations | In the breast cancer cell lines, PITX2 DNA methylation was inversely association with PITX2A and PITX2B mRNA expression (P < 0.01). | 17965955 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. | 17967182 |
| Adenocarcinoma, Neoplasms | Epigenetic Alterations | We identified thirteen loci showing significant differential DNA methylation levels between tumor and non-tumor lung; eight of these show highly significant hypermethylation in adenocarcinoma: CDH13, CDKN2A EX2, CDX2, HOXA1, OPCML, RASSF1, SFPR1, and TWIST1 (p-value << 0.0001). | 17967182 |
| Adenocarcinoma of lung (disorder), Neoplasms | Epigenetic Alterations | DNA methylation of these loci did not differ significantly based on gender, race, age or tumor stage, indicating their wide applicability as potential lung adenocarcinoma markers. | 17967182 |
| Adenocarcinoma of lung (disorder), Neoplasms | Epigenetic Alterations | The four most highly ranked loci, CDKN2A EX2, CDX2, HOXA1 and OPCML, which show significant DNA methylation even in stage IA tumor samples, merit further investigation as some of the most promising lung adenocarcinoma markers identified to date. | 17967182 |
| Carcinogenesis | Epigenetic Alterations | This could play an important role in carcinogenesis through the degree of DNA methylation and of nucleotide synthesis. | 17967524 |
| Carcinogenesis | Epigenetic Alterations | Our results also suggest that an aberrant DNA methylation pattern, through impaired folate metabolism, might play a key role in gastric carcinogenesis. | 17972183 |
| Primary malignant neoplasm | Epigenetic Alterations | Further investigation of the role of miRNAs and their regulation in cancer is warranted. | 17974952 |
| Malignant Neoplasms | Epigenetic Alterations | Evidence has highlighted the role of abnormal DNA methylation patterns on inappropriate gene expression in development and progression of various cancers. | 17979520 |
| Aggressive behavior | Epigenetic Alterations | No association of genetic and epigenetic alterations with histological type, tumor aggressiveness, and invasion was found (P > 0.05), which may be attributable to small sample size. | 17981214 |
| Neoplasms | Epigenetic Alterations | Our findings predict that epigenetic events play a significant role in human tumors that express high levels of c-Myc. | 17982115 |
| Breast Carcinoma | Epigenetic Alterations | The epigenetic alterations involved in the onset and progression of breast cancer may serve as biomarkers for early detection and prognosis of the disease. | 17998817 |
| nervous system disorder, Rett Syndrome, Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation of individual genes is a hallmark of cancer and has been shown to play an important role in neurological disorders such as Rett syndrome. | 17999367 |
| Primary malignant neoplasm | Epigenetic Alterations | We determined the quantitative DNA methylation levels of 1,505 CpG sites representing 807 genes with diverse functions, including proliferation and differentiation, previously shown to be implicated in human cancer. | 17999367 |
| Malignant neoplasm of lung, Neoplasms | Epigenetic Alterations | Lung cancers develop via multiple genetic and epigenetic changes, including inactivation of tumor suppressor genes. | 18000218 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We have analyzed both genetic (mutations of BRAF, KRAS, and p53 and microsatellite instability) and epigenetic alterations (DNA methylation of 27 CpG island promoter regions) in 97 primary colorectal cancer patients. | 18003927 |
| Malignant tumor of colon | Epigenetic Alterations | Unsupervised hierarchical clustering of the DNA methylation data identified three distinct groups of colon cancers named CpG island methylator phenotype (CIMP) 1, CIMP2, and CIMP negative. | 18003927 |
| Malignant tumor of colon | Epigenetic Alterations | Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. | 18003927 |
| Malignant tumor of colon | Epigenetic Alterations | Colon cancer has been viewed as the result of progressive accumulation of genetic and epigenetic abnormalities. | 18003927 |
| Malignant tumor of colon | Epigenetic Alterations | Together, our integrated genetic and epigenetic analysis reveals that colon cancers correspond to three molecularly distinct subclasses of disease. | 18003927 |
| Carcinogenesis | Epigenetic Alterations | One of the earliest and most common epigenetic events in prostate carcinogenesis is DNA CpG island (CGI) hypermethylation. | 18004747 |
| Functional disorder | Epigenetic Alterations | Cultured human mammary epithelial cells that lack p16(INK4a) activity have been shown to exhibit premalignant phenotypes, such as telomeric dysfunction, centrosomal dysfunction, a sustained stress response, and, most recently, a dysregulation of chromatin remodeling and DNA methylation. | 18006786 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | These data suggest that cells that lack p16(INK4a) activity would be at high risk for breast cancer development and may exhibit an increased frequency of DNA methylation events in early cancer. | 18006786 |
| Malignant Neoplasms, Imprinting (Psychology), Primary malignant neoplasm, Alloisoleucine | Epigenetic Alterations | Loss of imprinting (LOI) is a common epigenetic event in cancer and may serve as an early biomarker in some cancers. | 18006818 |
| Carcinogenesis | Epigenetic Alterations | Changes in DNA methylation have been reported to occur early in carcinogenesis and therefore are potentially important early indicators of existing disease. | 18025318 |
| Primary malignant neoplasm | Epigenetic Alterations | The clinical implications of these genes as diagnostic and treatment biomarkers are highly relevant as attractive targets for cancer therapy, given the reversible nature of epigenetic gene silencing. | 18025318 |
| Neoplasms | Epigenetic Alterations | To identify new regions of epigenetic perturbation in WTs, we screened kidney and tumor DNA using CpG island (CGI) tags associated with cancer-specific DNA methylation changes. | 18030365 |
| Nephroblastoma, Neoplasms | Epigenetic Alterations | Wilms tumors (WTs) have a complex etiology, displaying genetic and epigenetic changes, including loss of imprinting (LOI) and tumor suppressor gene silencing. | 18030365 |
| Acute lymphocytic leukemia, Neoplasms | Epigenetic Alterations | We have demonstrated that WNT5A, a putative tumour suppressor gene in ALL, is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression and confers poor prognosis in this group of patients. | 18032022 |
| Prostate Cancer Pathway | Epigenetic Alterations | These findings show that AI at 13q14.2 approximately q14.3 is an important event in the progression of localized prostate cancer, and suggest a possible role for microRNAs. | 18036398 |
| NCI CTEP SDC Choroid Plexus Tumors Sub-Category Terminology | Epigenetic Alterations | DNA methylation patterns of the CDH1, RARB, and SFN genes in choroid plexus tumors. | 18036402 |
| Neoplasms, Neuroepithelial | Epigenetic Alterations | Genetic and epigenetic alterations in choroid plexus tumors, a rare neuroepithelial neoplasm most frequently detected in children, are poorly characterized. | 18036402 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Epigenetic silencing associated with aberrant CpG island methylation is one mechanism leading to the loss of tumor suppressor functions in cancer cells. | 18036402 |
| Disease | Epigenetic Alterations | Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation and pathogenesis of human diseases. | 18042587 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | This work indicates that miRNAs are potential diagnosis biomarkers and probable factors involved in the pathogenesis of SLE. | 18042587 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations. | 18048385 |
| Malignant tumor of colon | Epigenetic Alterations | Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. | 18054557 |
| Primary malignant neoplasm | Epigenetic Alterations | These results further highlight the applicability of miRNA expression patterns as potential markers of human cancer, and our results suggest that FFPE tissues are suitable resources for such miRNA expression analyses. | 18058265 |
| Multinodular goiter, Papillary thyroid carcinoma | Epigenetic Alterations | Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues. | 18058265 |
| Methylnitronitrosoguanidine | Epigenetic Alterations | We identified 13 miRNAs upregulated and 26 miRNAs downregulated in PTC versus MNG. | 18058265 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Our results suggest that epigenetic silencing of RUNX3 gene expression by promoter hypermethylation may play an important role in ESCC development. | 18058463 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | The common occurrence of microscopic GISTs compared with the rarity of clinically manifest and malignant esophagogastric GISTs suggests that additional genetic or epigenetic alterations must happen for neoplastic progression. | 18059218 |
| Prostate Cancer Pathway, Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation is a hallmark of carcinogenesis and GSTP1 hypermethylation is the most common molecular alteration in human prostate cancer. | 18076912 |
| Colorectal Carcinoma | Epigenetic Alterations | Utilizing 903 population-based colorectal cancers and real-time PCR (MethyLight), we quantified DNA methylation in WRN and eight other promoters (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1) known to be specific for CIMP. | 18084250 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation biomarkers for blood-based colorectal cancer screening. | 18089654 |
| Hodgkin Disease | Epigenetic Alterations | MicroRNA expression profiling in classic Hodgkin lymphoma. | 18089852 |
| Communicable Diseases, Hodgkin Disease | Epigenetic Alterations | We analyzed miRNA expression in classic Hodgkin lymphoma (cHL) and the influence of Epstein-Barr virus (EBV) infection on the miRNA expression profiles. | 18089852 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer. | 18094410 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Interestingly, the cluster of reported methylation markers used in the U.S. bladder cancers is distinctly different from that identified in this study, suggesting a possible epigenetic disparity between the American and Chinese cases. | 18094410 |
| Non-Cancer Related Death, CTSG gene, Chronic gastritis | Epigenetic Alterations | These markers were then analyzed in a tester set of 25 paired GC and GCN and 27 chronic gastritis (CG) from non-cancer patients to generate their DNA methylation profiles. | 18158559 |
| Stomach Carcinoma | Epigenetic Alterations | Treatment with the demethylating agent, 5-aza-2-deoxycytidine (5-Aza-dC) resulted in the restoration of REG3A mRNA expression in the gastric cancer cell line, indicating that the transcriptional silencing of REG3A in SNU cell lines was caused by DNA methylation. | 18160850 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Aberrant DNA methylation is an important epigenetic alteration in hepatocellular carcinoma (HCC). | 18161048 |
| Hepatitis B, Hepatitis C, Infection | Epigenetic Alterations | Methylation of 19 epigenetic markers was quantified, and the results were correlated with different disease states and the presence or absence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. | 18161048 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | Extensive genetic and epigenetic analysis of poorly differentiated colorectal adenocarcinomas (Por) has been difficult, as the number of cases is too small. | 18161865 |
| Neoplasms | Epigenetic Alterations | The cases of WD were matched with the cases of Por for T classification and tumor location, which influence genetic and epigenetic alterations. | 18161865 |
| Malignant Neoplasms | Epigenetic Alterations | Systemic inhibition of DNA methylation causes cancers in animals, in part by inducing genetic instability. | 18166347 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA signature predicts survival and relapse in lung cancer. | 18167339 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. | 18167339 |
| Primary malignant neoplasm, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients. | 18167339 |
| Hollings Cancer Center | Epigenetic Alterations | A total of 15 miRNAs exhibited higher expression in the HCC samples than that in the NT samples, and one miRNA demonstrated lower expression in the HCC samples than in the NT samples. | 18171346 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation, and pathogenesis of human diseases including cancer. | 18171346 |
| Hollings Cancer Center | Epigenetic Alterations | A total of 18 miRNAs identified valid expression only in HCC samples, with six only in NT samples. | 18171346 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Neoplasms | Epigenetic Alterations | To evaluate aberrant promoter hypermethylation of candidate tumor suppressor genes as a means to detect epigenetic alterations specific to solid tumors, including head and neck squamous cell carcinoma (HNSCC). | 18172258 |
| Breast Carcinoma | Epigenetic Alterations | Folate plays an essential role in DNA methylation and synthesis, and thus may be involved in the development of breast cancer. | 18174236 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | Furthermore, the 20-miRNA tumor signature was validated in 110 additional cases as a significant independent predictor of survival (P = 0.009) and was significantly associated with both survival and relapse in 89 cases of early stage HCC (P = 0.022 and 0.002, respectively). | 18176954 |
| Hollings Cancer Center | Epigenetic Alterations | These 20 miRNAs may provide a simple profiling method to assist in identifying patients with HCC who are likely to develop metastases/recurrence. | 18176954 |
| Hypertensive disease | Epigenetic Alterations | Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension. | 18178212 |
| Hypertensive disease | Epigenetic Alterations | Little is known, however, of human HSD11B2 epigenetic control and its relationship with the onset of hypertension. | 18178212 |
| Hypertensive disease | Epigenetic Alterations | These results show a clear link between the epigenetic regulation through repression of HSD11B2 in PBMC DNA and hypertension. | 18178212 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | To measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China. | 18186556 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. | 18187662 |
| FLT3 Internal Tandem Duplication | Epigenetic Alterations | miRNA expression was also closely associated with selected cytogenetic and molecular abnormalities, such as t(11q23), isolated trisomy 8, and FLT3-ITD mutations. | 18187662 |
| FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute | Epigenetic Alterations | In conclusion, miRNA expression in AML is closely associated with cytogenetics and FLT3-ITD mutations. | 18187662 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | We identified several miRNAs differentially expressed between CD34(+) normal cells and the AML samples. | 18187662 |
| Primary malignant neoplasm | Epigenetic Alterations | Since gene deregulation is one of the key mechanisms by which cells can progress to cancer, we hypothesize that common polymorphisms within miRNA-target binding sites could play a role in the individual risk of cancer. | 18192692 |
| Primary malignant neoplasm | Epigenetic Alterations | These results are the first reporting positive association between miRNA-binding SNPs sequences and cancer risk. | 18192692 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer. | 18192692 |
| Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation has emerged as a promising biomarker for prostate cancer detection. | 18196513 |
| Clinical Coordinator | Epigenetic Alterations | miRNA expression levels were also correlated with commonly used clinicopath-ologic features of CRC. | 18196926 |
| Neoplasms | Epigenetic Alterations | Inactivation of tumour-related genes by promoter hypermethylation is a common epigenetic event in the development of a variety of tumours. | 18211945 |
| Uveal melanoma, melanoma | Epigenetic Alterations | As promoter methylation of APC, RASSF1 and RARB is often observed in cutaneous melanoma, these results suggest that different epigenetic events occur in the development of cutaneous and uveal melanoma. | 18211945 |
| Behavior | Epigenetic Alterations | High activity of histone deacetylases (HDACs) causes epigenetic alterations associated with malignant cell behaviour. | 18212746 |
| Clinical Observations Supplemental Qualifiers Dataset | Epigenetic Alterations | Both show ubiquitous inactivation of TP53 (pPCL 56%; sPCL 83%) by coding mutation or 17p13 deletion; complemented by p14ARF epigenetic silencing in sPCL (29%). | 18216867 |
| Malignant neoplasm of esophagus | Epigenetic Alterations | Furthermore, GNG7-transfected oesophageal cancer cells were analysed in laboratory studies at genomic and epigenetic levels. | 18219292 |
| Malignant neoplasm of esophagus | Epigenetic Alterations | In addition, GNG7 expression was significantly associated with the presence of miR328 in oesophageal cancer cell lines, which suggests that this microRNA might be a regulator of GNG7 expression. | 18219292 |
| Adenocarcinoma of colon | Epigenetic Alterations | MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. | 18230780 |
| Adenocarcinoma of colon | Epigenetic Alterations | To identify microRNA expression patterns associated with colon adenocarcinomas, prognosis, or therapeutic outcome. | 18230780 |
| Neoplasms, Adenocarcinoma of colon | Epigenetic Alterations | MicroRNA microarray expression profiling of tumors and paired nontumorous tissues was performed on a US test cohort of 84 patients with incident colon adenocarcinoma, recruited between 1993 and 2002. | 18230780 |
| Neoplasms, Cessation of life | Epigenetic Alterations | MicroRNAs that were differentially expressed in tumors and microRNA expression patterns associated with survival using cancer-specific death as the end point. | 18230780 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs have potential as diagnostic biomarkers and therapeutic targets in cancer. | 18230780 |
| Neoplasms | Epigenetic Alterations | RESULTS Thirty-seven microRNAs were differentially expressed in tumors from the test cohort. | 18230780 |
| Adenocarcinoma of colon | Epigenetic Alterations | Expression patterns of microRNAs are systematically altered in colon adenocarcinomas. | 18230780 |
| Alzheimers Disease | Epigenetic Alterations | The expression of microRNA miR-107 decreases early in Alzheimers disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. | 18234899 |
| Childhood Leukemia, Primary malignant neoplasm | Epigenetic Alterations | Epigenetic modulation of gene expression plays an important role in cancer, including leukemia. | 18245545 |
| UROD wt Allele | Epigenetic Alterations | UPD was detected in 4 samples; 2 samples involved whole chromosome 13 resulting in homozygous deletion of micro-RNA-15a (miR-15a)/miR-16-1. | 18246537 |
| Agenesis of corpus callosum | Epigenetic Alterations | Cell cycle disruption induced by these epigenetic aberrations might be important in the tumorigenesis of ACC. | 18254776 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas. | 18261630 |
| Colorectal Carcinoma | Epigenetic Alterations | In vitro study found elevated KLF4 mRNA expression in SW620 and RKO cells with 5-aza-dC treatment, implicating the underlying aberrant epigenetic modifications in regulating KLF4 expression at least in a subset of colorectal cancers. | 18264726 |
| Adenoma of large intestine, Malignant Neoplasms | Epigenetic Alterations | KLF4 is associated with terminal differentiation in colorectal epithelium and drastically downregulated in colorectal adenomas and cancers via possible epigenetic modifications. | 18264726 |
| Carcinogenesis | Epigenetic Alterations | Disturbances in DNA methylation are a characteristic of colorectal carcinogenesis. | 18268116 |
| Carcinogenesis | Epigenetic Alterations | These gene-diet interactions suggest that polymorphisms relevant to DNA methylation or alcohol metabolism may play a role in colorectal carcinogenesis in conjunction with a high-risk diet. | 18268116 |
| Thyroid Neoplasm | Epigenetic Alterations | MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility. | 18270258 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miRNA) expression is deregulated in many types of human cancers. | 18270258 |
| Thyroid Neoplasm | Epigenetic Alterations | Various histopathological types of thyroid tumors, including those deriving from the same cell type, showed significantly different profiles of miRNA expression. | 18270258 |
| Carcinoma, Papillary | Epigenetic Alterations | Significant correlation between miRNA expression patterns and somatic mutations was observed in papillary carcinomas. | 18270258 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Aberrant DNA methylation of these loci was found in 94% of all GIST. | 18271923 |
| Glioma, Neoplasms | Epigenetic Alterations | Therefore, we conclude that the tumor suppressor role of PAX6, reported in previous studies on gliomas, is not due to mutation in its coding and regulating regions, suggesting the involvement of epigenetic mechanisms in the silencing of PAX6 in these tumors. | 18273794 |
| Carcinogenesis | Epigenetic Alterations | It is possible that endogenous 8-oxo-7,8-dihydroguanine (8-oxoGua) level may be linked to aberrant DNA methylation of adjacent cytosine and in this way influences carcinogenesis. | 18281064 |
| Carcinogenesis | Epigenetic Alterations | Our work provides the first in vivo evidence suggesting that increased levels of 8-oxodG in DNA may lead to carcinogenesis not only via mispair/mutagenic potential of the modified base but also through its ability to influence gene expression by affecting DNA methylation. | 18281064 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. | 18283041 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | Based on these results, we propose that PKD1 is frequently silenced by epigenetic regulation, which plays a role in cell migration and metastasis in gastric cancer. | 18283041 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Loss of interferon-gamma inducibility of the MHC class II antigen processing pathway in head and neck cancer: evidence for post-transcriptional as well as epigenetic regulation. | 18284388 |
| Carcinogenesis | Epigenetic Alterations | Increased expression of Cx32 in metastases to the lymph nodes might reflect alteration in connexin gene transcription during breast carcinogenesis and finally, it may be a sign of more malignant phenotype of cancerous cells. | 18292829 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The etiology of esophageal squamous cell carcinoma (ESCC) has been shown to be multifactorial, including genetic, epigenetic, and environmental factors, such as tobacco smoking. | 18294291 |
| Penis carcinoma | Epigenetic Alterations | However, so far, only a few studies have searched for DNA methylation in penile carcinoma (PC). | 18299890 |
| Squamous Cell Carcinoma of the Penis | Epigenetic Alterations | Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas. | 18299890 |
| Hepatitis C Virus-Related Hepatocellular Carcinoma | Epigenetic Alterations | MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. | 18307259 |
| Carcinogenesis | Epigenetic Alterations | Many fundamental biological processes are modulated by microRNAs, and an important role for microRNAs in carcinogenesis is emerging. | 18307259 |
| Primary Neoplasm, Neoplasms | Epigenetic Alterations | A subset of microRNAs are aberrantly expressed in primary liver tumors, serving both as putative tumor suppressors and as oncogenic regulators. | 18307259 |
| septic | Epigenetic Alterations | Consequently, septic neutrophils are promptly responsive to IL-10 in vitro, as revealed by a direct IL-10-mediated induction of STAT3 tyrosine phosphorylation and SOCS-3 gene transcription, mRNA and protein expression. | 18308712 |
| Hematopoietic Neoplasms | Epigenetic Alterations | Recent studies have suggested that menin may act as a scaffold protein to coordinate gene transcription, and that menin is an oncogenic cofactor for homeobox (HOX) gene expression in hematopoietic cancer. | 18310293 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion. | 18314483 |
| Malignant neoplasm of penis | Epigenetic Alterations | In summary, the epigenetic inactivation of TSP-1 and RASSF1-A genes is associated with pathological variables and seems to be of prognostic significance in penile cancer. | 18336597 |
| Carcinoma of lung | Epigenetic Alterations | DNA methylation markers and early recurrence in stage I lung cancer. | 18337602 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | The positive associations between folate intake and tumors harboring BRAF mutations and between vitamin B6 intake and those showing MLH1 hypermethylation were most pronounced among men and may suggest that these vitamins enhance colorectal cancer risk through genetic as well as epigenetic aberrations. | 18339680 |
| Primary Neoplasm, Neoplasms | Epigenetic Alterations | This epigenetic event may lead to progressive silencing of tumor suppressor genes, including RUNX3, in these epithelial cells, which also occurred in primary breast tumors. | 18339859 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | The high prevalence of estrogen-induced epigenetic changes in primary tumors and the surrounding histologically normal tissues provides the first empirical link between estrogen injury of breast stem/progenitor cells and carcinogenesis. | 18339859 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | This finding also offers a mechanistic explanation as to why a tumor suppressor gene, such as RUNX3, can be heritably silenced by epigenetic mechanisms in breast cancer. | 18339859 |
| Breast Carcinoma | Epigenetic Alterations | The pathogenesis of breast cancer involves multiple genetic and epigenetic events. | 18346456 |
| Breast Carcinoma | Epigenetic Alterations | In this study, we report an epigenetic alteration of DFNA5 in human breast cancer. | 18346456 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. | 18349282 |
| Hollings Cancer Center | Epigenetic Alterations | This indicates that these epigenetic events may serve as a good marker for HCC. | 18351580 |
| Lewy Body Disease, Dementia | Epigenetic Alterations | It suggested that epigenetic methylation of circadian gene was more prevalent in dementia patients, especially for the DLB patients. | 18358604 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | DNA methylation and loss of protein expression in esophageal squamous cell carcinogenesis of high-risk area. | 18365557 |
| Colorectal Carcinoma | Epigenetic Alterations | Utilizing 869 population-based colorectal cancers, we measured long interspersed nucleotide element-1 (LINE-1) methylation level by Pyrosequencing, which correlates with global DNA methylation level. | 18366060 |
| SF3B1 wt Allele, Neoplasms, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | The epigenetic changes of tumor suppressor genes (TSG) are now recognized as an abnormal mechanism contributing to the development of myelodysplastic syndrome (MDS). | 18367246 |
| Dermatologic disorders, Psoriasis | Epigenetic Alterations | Alteration of the p16INK4a gene by epigenetic changes has been described in some hyperproliferative skin diseases, but its importance in psoriasis has not yet been established. | 18373711 |
| Breast Carcinoma | Epigenetic Alterations | Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy. | 18377693 |
| Neoplasms | Epigenetic Alterations | An increase in DNA repair enzymes and disappearance of DNA methylation patterns attributes to reduction in tumour burden and may suggest good prognosis and efficacy of the treatment. | 18377693 |
| Malignant Neoplasms | Epigenetic Alterations | Both genetic (mutations, deletions, chromosomal rearrangements) and epigenetic (aberrant methylation of the 5CpG island) alterations of the FHIT gene have been reported in various malignancies. | 18378390 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Epigenetic changes play an important role in cancer pathogenesis through transcriptional silencing of critical tumor suppressor genes. | 18385750 |
| Aggressive behavior | Epigenetic Alterations | Effect of DNA methylation on identification of aggressive prostate cancer. | 18387661 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation of promoter regions leads to gene silencing in many cancers. | 18387661 |
| Stomach Carcinoma | Epigenetic Alterations | Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer. | 18395906 |
| Neoplasms | Epigenetic Alterations | Having previously assessed relative methylation in blood-derived DNA, we compared tumor with the blood DNA methylation level and observed these to be independent. | 18398038 |
| Aggressive behavior | Epigenetic Alterations | These findings suggest that HPV-associated tumors differ molecularly from those arising after heavy tobacco use and that this epigenetic alteration may affect survival in HPV-negative patients already exhibiting a more aggressive disease. | 18398038 |
| cervical cancer | Epigenetic Alterations | Identification of novel DNA methylation markers in cervical cancer. | 18398837 |
| Primary malignant neoplasm | Epigenetic Alterations | Testing for DNA methylation has potential in cancer screening. | 18398837 |
| cervical cancer | Epigenetic Alterations | Most previous studies of DNA methylation in cervical cancer used a candidate gene approach. | 18398837 |
| cervical cancer | Epigenetic Alterations | The analysis of these novel DNA methylations may be a promising approach for the screening of cervical cancers. | 18398837 |
| Colorectal Carcinoma | Epigenetic Alterations | Another hypermethylation pattern found in colorectal cancers, termed long-range epigenetic silencing, is associated with DNA/histone methylation in three distinct gene clusters at chromosome 2q14.2, showing that DNA hypermethylation can span larger chromosomal domains and lead to the silencing of flanking, unmethylated genes. | 18403637 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The CpG island methylator phenotype correlates with long-range epigenetic silencing in colorectal cancer. | 18403637 |
| Kidney Failure, Acute, Adenocarcinoma Of Esophagus | Epigenetic Alterations | The results suggest that silencing of ARF is involved in the pathogenesis of oesophageal adenocarcinoma and show that either DNA or histone methylation can provide the primary mechanism for ARF gene silencing. | 18410530 |
| Liver neoplasms | Epigenetic Alterations | Through comparison of RNA polymerase II binding, chromatin structure, DNA methylation, and copy number changes, we suggest that the major contributor to creation of the liver tumor transcriptome was changes in gene copy number. | 18413731 |
| Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome | Epigenetic Alterations | Despite this, pursuing DNMT1 down-regulation remains a sound approach for targeting aberrant epigenetics in AML/MDS. | 18413836 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetic silencing via aberrant promoter DNA hypermethylation of normal genes has been described as a leukemogenic mechanism in myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML). | 18413836 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The abnormality of DNA methylation is involved in tumour progression, and thus has a modulating effect on clinical outcome of cancer patients. | 18414412 |
| Colorectal Neoplasms | Epigenetic Alterations | In most colorectal tumours, APC mutation stabilises beta-catenin and mimics elements of Wnt growth factor signalling, but the high frequency of epigenetic loss of Wnt antagonists indicates an additional role for ligand-mediated Wnt signalling. | 18414471 |
| Antigen-Presenting Cells, APC wt Allele | Epigenetic Alterations | Individual steps in the tumorigenesis pathway, that is, adenomatosis polyposis coli (APC), Wnt-activated, base excision repair mutations, mismatch repair defects, RAF-mediated, transforming growth factor (TGF)-beta-suppressed, bone morphogenic protein (BMP)-suppressed, and p53 alterations, were examined in terms of genetic and epigenetic changes, as well as protein expression. | 18422752 |
| Malignant Neoplasms, Malignant neoplasm of stomach | Epigenetic Alterations | Malignant tumours of the stomach are common, but the incidence of stomach cancer varies from country to country, probably a result of genetic, epigenetic and environmental factors. | 18424576 |
| Primary malignant neoplasm | Epigenetic Alterations | Several miRNAs play crucial roles in cancer cell growth. | 18429962 |
| Stomach Carcinoma | Epigenetic Alterations | In vivo, an inverse relationship between expression of the EZH2 and RUNX3 proteins was observed at the individual cell level in gastric cancer patients in the absence of DNA methylation in the RUNX3 promoter region. | 18430739 |
| Clinical Coordinator, Lynch Syndrome | Epigenetic Alterations | Additionally, aberrant DNA methylation is a common event not only in sporadic CRC but also in Lynch syndrome CRCs. | 18435933 |
| Colorectal Carcinoma | Epigenetic Alterations | Colorectal cancers (CRCs) with the CpG island methylator phenotype (CIMP) often associate with epigenetic silencing of hMLH1 and an activating mutation in the BRAF gene. | 18435933 |
| Adenocarcinoma of pancreas | Epigenetic Alterations | Few genetic mutations have been identified in pancreatic adenocarcinoma, whereas epigenetic changes that lead to gene silencing are known in several genes. | 18437076 |
| Malignant Neoplasms, Pancreatic carcinoma, Neoplasms | Epigenetic Alterations | Because SLC5A8 is regarded as a potential tumor suppressor gene that is down-regulated by epigenetic changes in several other cancers, we sought to characterize promoter methylation status and its relationship to SLC5A8 expression in pancreatic cancer. | 18437076 |
| Pancreatic carcinoma, Carcinogenesis, Neoplasms | Epigenetic Alterations | We suggest that SLC5A8 may function as a tumor suppressor gene whose silencing by epigenetic changes may contribute to carcinogenesis and progression of pancreatic cancer. | 18437076 |
| Autoimmune state | Epigenetic Alterations | Epigenetic changes in gene expression, including DNA methylation and histone modifications, might contribute to autoimmunity. | 18437543 |
| Disease | Epigenetic Alterations | Several microRNA, which are approximately 22-nucleotide noncoding RNAs, exhibit tissue-specific or developmental stage-specific expression patterns and are associated with human diseases. | 18438844 |
| Rheumatoid Arthritis | Epigenetic Alterations | Expression of microRNA-146 in rheumatoid arthritis synovial tissue. | 18438844 |
| ovarian neoplasm | Epigenetic Alterations | Components of the miRNA processing machinery, such as Dicer and Drosha are not responsible for miRNA deregulation in recurrent ovarian cancer, as deluded by TaqMan and immunohistochemistry. | 18442408 |
| ovarian neoplasm | Epigenetic Alterations | We propose a miRNA model for the molecular pathogenesis of recurrent ovarian cancer. | 18442408 |
| ovarian neoplasm | Epigenetic Alterations | Based on integrated transcriptome and miRNA analysis, miR-9 and miR-223 can be of potential importance as biomarkers in recurrent ovarian cancer. | 18442408 |
| Cervix carcinoma | Epigenetic Alterations | Altered MicroRNA expression in cervical carcinomas. | 18451214 |
| Malignant Neoplasms | Epigenetic Alterations | Emerging evidence suggests that miRNAs might be involved in the pathogenesis of a variety of human cancers. | 18451214 |
| Metastasis | Epigenetic Alterations | When we analyzed the expression of the 10 most significant miRNAs in 31 ISCCs, increased miR-127 expression was significantly associated with lymph node metastasis (P = 0.006). | 18451214 |
| Colorectal Carcinoma | Epigenetic Alterations | Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. | 18451217 |
| Adenomatous Polyposis Coli | Epigenetic Alterations | Early events in colorectal tumorigenesis include mutation of the adenomatous polyposis coli (APC) gene and epigenetic hypermethylation with transcriptional silencing of the O(6)-methylguanine DNA methyltransferase (MGMT), human mut L homologue 1 (hMLH1), and P16/CDKN2A genes. | 18451217 |
| Neoplasms | Epigenetic Alterations | Our findings suggest that the heterogeneous epigenetic dysregulation of promoter methylation in various genes is interrelated with the occurrence of mutations, as manifested in epigenetic-genetic subgroups of tumors. | 18451217 |
| palladium | Epigenetic Alterations | For selected transcripts, transcriptional alterations were confirmed with qPCR on a larger set of seven PD cases and seven matched controls. | 18462474 |
| Squamous cell carcinoma | Epigenetic Alterations | Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling. | 18464261 |
| Squamous cell carcinoma | Epigenetic Alterations | Currently, there is no information concerning miRNA expression and functions in squamous cell carcinoma (SCC) of tongue. | 18464261 |
| Glioblastoma Multiforme | Epigenetic Alterations | Furthermore, in 3 out of 4 available H1/H2alpha heterozygous human glioblastoma cell lines, H1-derived mRNA levels were more than 10-fold lower than from H2alpha, resulting at least in part from haplotype-specific epigenetic differences such as DNA methylation and histone acetylation. | 18464291 |
| SF3B1 wt Allele, Tetraploidy | Epigenetic Alterations | Our data suggest that the unique complex abnormality of tetraploidy and 5q deletion described here for the first time in MDS is characterized by distinct disease etiology, the mechanism of which could involve epigenetic inactivation of gene expression via methylation. | 18474300 |
| Pancreatic carcinoma | Epigenetic Alterations | Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer. | 18475302 |
| Pancreatic carcinoma | Epigenetic Alterations | Therefore, we examined genetic and epigenetic alterations of RUNX3 in human pancreatic cancer. | 18475302 |
| Neoplasms | Epigenetic Alterations | Tumors readily clustered based on miRNA expression into two groups that corresponded to the gene expression-based subtypes: class 1 (low metastatic risk) and class 2 (high metastatic risk). | 18477892 |
| Neoplasms | Epigenetic Alterations | A classifier that included the top six miRNA discriminators accurately distinguished class 1 from class 2 tumors with 100% sensitivity and specificity. | 18477892 |
| Uveal melanoma | Epigenetic Alterations | miRNA expression may represent a highly accurate biomarker for metastatic risk in uveal melanoma. | 18477892 |
| Neoplasms | Epigenetic Alterations | In addition, these results may provide new insights into the role of miRNAs in tumor progression and the metastatic phenotype. | 18477892 |
| Uveal melanoma, Metastasis | Epigenetic Alterations | Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling. | 18477892 |
| ovarian neoplasm | Epigenetic Alterations | HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer. | 18478570 |
| Malignant neoplasm of ovary, ovarian neoplasm | Epigenetic Alterations | To identify potential, prognostic DNA methylation markers in ovarian cancer we analyzed the DNA methylation at 71 different loci in 22 ovarian cancers and 18 non-neoplastic ovarian specimens by means of a quantitative, real-time PCR-based technique (MethyLight). | 18478570 |
| Primary malignant neoplasm | Epigenetic Alterations | We identified DNA methylation of HOXA10 and HOXA11, both of them PcGTs, to be the best discriminators between cancer and non-neoplastic tissue. | 18478570 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | In an independent set consisting of 92 ovarian cancer specimens further analysis demonstrated that HOXA11 DNA methylation is (i) strongly associated with the residual tumor after cytoreductive surgery and (ii) is a marker indicating poor prognosis. | 18478570 |
| Cessation of life | Epigenetic Alterations | HOXA11 DNA methylation was independently associated with poor outcome [relative risk for death 3.4 (95% CI 1.2-9.9; p = 0.03)]. | 18478570 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations play a major role in cancer. | 18478570 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation in benign breast epithelium in relation to age and breast cancer risk. | 18483325 |
| Multiple Myeloma | Epigenetic Alterations | Epigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival. | 18483358 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic changes in a group of glycosyltransferases including B4GALNT2 and ST3GAL6 represent a malignant phenotype of gastric cancer caused by silencing of the activity of these enzymes, which action may eventually induce aberrant glycosylation and expression of cancer-associated carbohydrate antigens. | 18485915 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulation of genetic and epigenetic alterations contribute to malignant transformation of normal colonic mucosa to cancer. | 18486467 |
| Carcinogenesis | Epigenetic Alterations | MBD4 (methyl-CpG binding domain protein 4) was identified as a methyl-CpG binding protein and plays an important role in DNA methylation and carcinogenesis. | 18495292 |
| Squamous cell carcinoma | Epigenetic Alterations | Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma. | 18497987 |
| Malignant neoplasm of ovary, ovarian neoplasm | Epigenetic Alterations | To explore the potential role of DNA methylation on HLA-G expression in ovarian cancer, we correlated differences in HLA-G expression with methylation changes within the HLA-G regulatory region in an ovarian cancer cell line treated with 5-aza-deoxycytidine (5-aza-dC) and in malignant and benign ovarian tumor samples and ovarian surface epithelial cells (OSE) isolated from patients with normal ovaries. | 18498645 |
| ovarian neoplasm | Epigenetic Alterations | Epigenetic changes within the promoter region of the HLA-G gene in ovarian tumors. | 18498645 |
| Neoplasms | Epigenetic Alterations | Previous findings have suggested that epigenetic-mediated HLA-G expression in tumor cells may be associated with resistance to host immunosurveillance. | 18498645 |
| Neoplasms | Epigenetic Alterations | There was no correlation between DNA methylation and E-cadherin protein levels in either tumors or matched normal tissues. | 18503162 |
| Primary malignant neoplasm | Epigenetic Alterations | The identification of target mRNAs is a key step for assessing the role of aberrantly expressed microRNAs in human cancer. | 18521080 |
| Neoplasms | Epigenetic Alterations | Recent evidence indicates that small noncoding RNA molecules known as microRNAs (miRNAs) can function as tumor suppressors and oncogenes. | 18521189 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Genetic variants of miRNA sequences and non-small cell lung cancer survival. | 18521189 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Mutation, misexpression, and altered mature miRNA processing are implicated in carcinogenesis and tumor progression. | 18521189 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Because SNPs in pre-miRNAs could alter miRNA processing, expression, and/or binding to target mRNA, we conducted a systematic survey of common pre-miRNA SNPs and their surrounding regions and evaluated in detail the association of 4 of these SNPs with the survival of individuals with non-small cell lung cancer (NSCLC). | 18521189 |
| Carcinoma of lung | Epigenetic Alterations | In the genotype-phenotype correlation analysis of 23 human lung cancer tissue samples, rs11614913 CC was associated with a statistically significant increase in mature hsa-mir-196a expression but not with changes in levels of the precursor, suggesting enhanced processing of the pre-miRNA to its mature form. | 18521189 |
| Primary malignant neoplasm | Epigenetic Alterations | Further characterization of miRNA SNPs may open new avenues for the study of cancer and therapeutic interventions. | 18521189 |
| Neoplasms | Epigenetic Alterations | In addition, we have analyzed the expression of five micro RNAs located within the 17q23.2-q25.3 region, but none of them showed high expression levels compared to the benign tumors. | 18522746 |
| Alzheimers Disease | Epigenetic Alterations | Identification of miRNA changes in Alzheimers disease brain and CSF yields putative biomarkers and insights into disease pathways. | 18525125 |
| Admitting diagnosis | Epigenetic Alterations | Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. | 18525125 |
| Admitting diagnosis, "Alzheimers Disease", Neurodegenerative Disorders | Epigenetic Alterations | MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimers disease (AD) is unknown. | 18525125 |
| Admitting diagnosis | Epigenetic Alterations | We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. | 18525125 |
| Idiopathic Interstitial Pneumonias | Epigenetic Alterations | Assessment of gene transcription demonstrates connection with the clinical course of idiopathic interstitial pneumonia. | 18525195 |
| Malignant Neoplasms | Epigenetic Alterations | Many genes undergo aberrant methylation in human cancers, and microarray platforms enable more comprehensive profiling of aberrant DNA methylation patterns. | 18535405 |
| Pancreatic carcinoma | Epigenetic Alterations | We used methylated CpG island amplification (MCA) and Agilent promoter and CpG island microarrays to identify differential DNA methylation patterns in pancreatic cancer vs. normal pancreas. | 18535405 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia. | 18537968 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | To analyse epigenetic dysregulation of SFRPs in acute myeloid leukaemia (AML), we examined the promoter methylation status of SFRP1, -2, -4 and -5 in AML cell lines by methylation-specific polymerase chain reaction (MSP). | 18537968 |
| Lymphoma, Follicular, Lymphoma | Epigenetic Alterations | MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas. | 18537969 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNA, miR) are negative regulators of gene expression that play an important role in diverse biological processes such as development, cell growth, apoptosis and haematopoiesis, suggesting their association with cancer. | 18537969 |
| Lymphoma, Follicular, Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Here we analysed the expression signatures of 157 miRNAs in 58 diffuse large B-cell lymphoma (DLBCL), 46 follicular lymphoma (FL) and seven non-neoplastic lymph nodes (LN). | 18537969 |
| Neoplasms | Epigenetic Alterations | Comparison of the possible combinations of DLBCL-, FL- and LN resulted in specific DLBCL- and FL-signatures, which include miRNAs with previously published function in haematopoiesis (MIRN150 and MIRN155) or tumour development (MIRN210, MIRN10A, MIRN17-5P and MIRN145). | 18537969 |
| Lymphoma | Epigenetic Alterations | As compared to LN, some miRNAs are differentially regulated in both lymphoma types (MIRN155, MIRN210, MIRN106A, MIRN149 and MIRN139). | 18537969 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Conversely, some miRNAs show lymphoma-specific aberrant expression, such as MIRN9/9*, MIRN301, MIRN338 and MIRN213 in FL and MIRN150, MIRN17-5P, MIRN145, MIRN328 and others in DLBCL. | 18537969 |
| Diffuse Large B-Cell Lymphoma, Neoplasms | Epigenetic Alterations | Finally, eight miRNAs were found to correlate with event-free and overall survival in DLBCL including known tumour suppressors (MIRN21, MIRN127 and MIRN34a) and oncogenes (MIRN195 and MIRNLET7G). | 18537969 |
| Breast Carcinoma | Epigenetic Alterations | Further, the interactions between DNA methylation and hormone receptor biology in breast cancer cells are beginning to be clearly understood. | 18538349 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic markers, in particular, those based on aberrant DNA methylation, can be used to diagnose cancer. | 18541613 |
| Neoplasms | Epigenetic Alterations | No correlation was found between DNA methylation of BAGE loci and age, gender of patients, nor with the tumor stage or site. | 18541613 |
| Malignant tumor of colon | Epigenetic Alterations | BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection. | 18541613 |
| Malignant tumor of colon | Epigenetic Alterations | These new markers enrich the list of currently studied epigenetic alterations in colon cancer and could be associated with hypermethylation markers to develop reliable diagnostic tests. | 18541613 |
| Neoplastic disease | Epigenetic Alterations | The apparently normal mucosal field of patients presenting with neoplasia has evidently undergone significant epigenetic modification. | 18542073 |
| Malignant Neoplasms, Gallbladder Carcinoma, Chronic cholecystitis, Carcinoma | Epigenetic Alterations | In order to determine the potential role of promoter methylation in gallbladder carcinogenesis, we investigated the frequency of this epigenetic mechanism by methylation-specific polymerase chain reaction (MSP) in 35 chronic cholecystitis (CC, separated according to the presence or absence of metaplasia), 19 early cancers (mucosa or muscularis propia invasion) and 48 advanced carcinomas with invasion of the gallbladder subserosa (25 cases) and serosa (23 cases). | 18543280 |
| Hepatocarcinogenesis, Hollings Cancer Center | Epigenetic Alterations | To gain insight into the role of epigenetic aberration of telomerase-related genes in hepatocarcinogenesis, we determined a hypermethylation profile in HCC. | 18546260 |
| B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 | Epigenetic Alterations | Abnormal DNA methylation of promoter-associated CpG islands in the Wnt signaling pathway is very common in Philadelphia chromosome-positive acute lymphoblastic leukemia and potentially defines subgroups with distinct clinical characteristics. | 18549404 |
| Breast Carcinoma | Epigenetic Alterations | Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. | 18550570 |
| Liver carcinoma | Epigenetic Alterations | Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells. | 18553387 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. | 18555017 |
| Neoplasms | Epigenetic Alterations | Specific microRNA (miR)-223 and miR-222 deregulations were verified in an independent series of tumors. | 18555017 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | In hepatocellular carcinoma (HCC), information on differentially expressed miRNA remained largely undefined. | 18555017 |
| Hepatitis B, Hepatitis C, Hollings Cancer Center | Epigenetic Alterations | Array-based miRNA profiling was performed on HCC cells that were derived from chronic carriers of hepatitis B virus (HBV) and hepatitis C virus (HCV), and nonviral-associated patients. | 18555017 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Epigenetic signatures of familial cancer are characteristic of tumor type and family category. | 18559504 |
| Malignant Neoplasms, Colorectal Carcinoma, Clinical Coordinator | Epigenetic Alterations | Although sporadic cancers, especially colorectal carcinoma (CRC), have been characterized for epigenetic changes extensively, such information in familial/hereditary cancer is limited. | 18559504 |
| Prostate Cancer Pathway | Epigenetic Alterations | Reactivation of SSBP2 expression by the demethylating agent 5-aza-2-deoxycytidine in prostate cancer cell lines confirmed epigenetic inactivation as one major mechanism of SSBP2 regulation. | 18559593 |
| Liver carcinoma | Epigenetic Alterations | Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma. | 18559595 |
| ABCB1 wt Allele | Epigenetic Alterations | In conclusion, epigenetic silencing of CXCL12 is a frequent event in NSCLCs, and could be an independent and powerful prognostic marker in patients with NSCLCs and those with stage I disease. | 18575756 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism. | 18575765 |
| Alzheimers Disease | Epigenetic Alterations | Expression of a noncoding RNA is elevated in Alzheimers disease and drives rapid feed-forward regulation of beta-secretase. | 18587408 |
| Alzheimers Disease | Epigenetic Alterations | These data show that BACE1 mRNA expression is under the control of a regulatory noncoding RNA that may drive Alzheimers disease-associated pathophysiology. | 18587408 |
| Alzheimers Disease | Epigenetic Alterations | In summary, we report that a long noncoding RNA is directly implicated in the increased abundance of Abeta 1-42 in Alzheimers disease. | 18587408 |
| Breast Carcinoma | Epigenetic Alterations | Multiple mechanisms involved in altering ERalpha gene expression in breast cancer have been identified, including ERalpha gene amplification as well as transcriptional silencing by DNA methylation of CpG islands within the ERalpha promoter and mutations within the open reading frame of ERalpha. | 18593897 |
| Malignant Neoplasms, Breast Carcinoma | Epigenetic Alterations | Recent evidence has shown that microRNA mutations or misexpression correlate with various human cancers, and miR-206 is reported to decrease endogenous ERalpha mRNA and protein levels in human MCF-7 breast cancer cells via two specific target sites within the 3-untranslated region of the human ERalpha transcript. | 18593897 |
| Malignant Neoplasms | Epigenetic Alterations | The concordant methylation is possibly a consequence of a long-range epigenetic effect in this region of chromosome 3p, which has recently been described in other cancers. | 18594535 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Genetic and epigenetic analysis of the VHL gene in gastric cancers. | 18607865 |
| Malignant neoplasm of stomach | Epigenetic Alterations | This is the first investigation of the genetic and epigenetic alterations of the VHL gene in gastric cancers. | 18607865 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Our results suggest that genetic and epigenetic alterations of the VHL gene may be not involved in the development or progression of gastric cancers. | 18607865 |
| Malignant neoplasm of liver, Hollings Cancer Center, Neoplasms | Epigenetic Alterations | Our current observations provide evidences that ARHI downregulated in HCCs could play a role in liver cancer via acting as a tumor suppressor gene, which mainly was triggered by the epigenetic events in HCC specimens. | 18612997 |
| Coronary Artery Disease | Epigenetic Alterations | Detection of altered global DNA methylation in coronary artery disease patients. | 18613790 |
| Arteriosclerosis | Epigenetic Alterations | Epigenetic modifications, especially alteration in DNA methylation, are increasingly being recognized as a key factor in the pathogenesis of complex disorders, including atherosclerosis. | 18613790 |
| Cardiovascular Diseases | Epigenetic Alterations | The alteration in genomic DNA methylation associated with cardiovascular disease per se appears to be further accentuated by higher homocysteine levels. | 18613790 |
| Coronary Artery Disease | Epigenetic Alterations | However, there are limited data on the epigenetic changes in the coronary artery disease (CAD) patients. | 18613790 |
| Diarrhea, Irritable Bowel Syndrome | Epigenetic Alterations | First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. | 18614545 |
| Malignant tumor of colon | Epigenetic Alterations | The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer. | 18615680 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. | 18616821 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Here we focused on developing DNA methylation markers for squamous cell carcinoma of the lung. | 18616821 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | We have identified 22 DNA methylation markers for squamous cell lung cancer, several of which have not previously been reported to be methylated in any type of human cancer. | 18616821 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | The top eight markers show great promise as a sensitive and specific DNA methylation marker panel for squamous cell lung cancer. | 18616821 |
| Colorectal Carcinoma | Epigenetic Alterations | Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients. | 18618713 |
| Hereditary | Epigenetic Alterations | The rather randomly distributed weak methylation patterns in hereditary CRCs indicate that epigenetic events are redundant in Lynch-syndrome etiology, in contrast to the widespread DNA methylation in sporadic unstable CRCs. | 18618713 |
| Malignant Neoplasms | Epigenetic Alterations | Loss of genomic imprinting is an epigenetic alteration of some cancers involving the absence of parental origin-specific expression of imprinted genes. | 18619647 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Many tumor genes are inactivated by DNA methylation in gastric cancer. | 18622497 |
| Myeloproliferative disease | Epigenetic Alterations | Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases. | 18623127 |
| Neoplasms | Epigenetic Alterations | MEG3 is an imprinted gene encoding a novel noncoding RNA that suppresses tumor cell growth. | 18628527 |
| Loading Technique | Epigenetic Alterations | We propose that epigenetic drift is likely to be a substantial mechanism predisposing individuals to LOAD and contributing to the course of disease. | 18628954 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Two alterations in the pattern of DNA methylation in breast cancer (BC) have been previously reported; active estrogen receptor-alpha (ER-alpha) is associated with decreased methylation of ER-alpha target (ERT) genes, and polycomb group target (PCGT) genes are more likely than other genes to have promoter DNA hypermethylation in cancer. | 18628976 |
| Chronic disease | Epigenetic Alterations | Further research will need to demonstrate whether DNA methylation profiles will be able to serve as a new tool to predict the risk of developing chronic diseases with sufficient accuracy to guide preventive measures. | 18628976 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic changes are emerging as one of the most important events in carcinogenesis. | 18628976 |
| Neoplasms | Epigenetic Alterations | Based on these results, we propose that the observed frequent epigenetic-mediated TCF4 silencing plays a role in tumor formation and progression. | 18635522 |
| Prostate Cancer Pathway | Epigenetic Alterations | Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer. | 18637271 |
| Malignant neoplasm of prostate | Epigenetic Alterations | Like EZH2 expression, DNA methylation alterations escalate in higher stage prostate cancers, raising the question whether these epigenetic changes are related. | 18637271 |
| Prostate Cancer Pathway | Epigenetic Alterations | Intriguingly, our data suggest a direct influence of increased EZH2 on altered DNA methylation patterns in prostate cancer. | 18637271 |
| Communicable Diseases | Epigenetic Alterations | The high frequency of oncogenic HPV types implicates maternal transmission of HPV and infection of an ectodermal stem cell leading to an epigenetic mosaic and altered skin development manifested along Blaschkos lines. | 18638629 |
| Neoplasms | Epigenetic Alterations | DNA methylation is a key regulator of gene transcription and genomic stability, and alterations in DNA methylation patterns are frequently detected in human tumors. | 18639281 |
| Bladder Neoplasm | Epigenetic Alterations | Previously we reported that inactivation of RUNX3 by primarily epigenetic alterations in DNA methylation is closely associated with bladder tumor development, recurrence and progression. | 18639281 |
| Carcinogenesis | Epigenetic Alterations | DNA-methyltransferase-3B (DNMT3B), which plays a role in DNA methylation, is usually aberrant expression involved in carcinogenesis. | 18662374 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methylation in several cancers, thereby modulating the susceptibility to cancer. | 18662374 |
| Childhood Medulloblastoma, Neoplasms | Epigenetic Alterations | Candidate gene investigations have indicated a significant role for epigenetic events in the pathogenesis of medulloblastoma, the most common malignant brain tumor of childhood. | 18664619 |
| Carcinoma of lung | Epigenetic Alterations | A high-throughput and sensitive method to measure global DNA methylation: application in lung cancer. | 18673580 |
| Carcinoma of lung | Epigenetic Alterations | We have applied the technology to understand the role of global DNA methylation in the natural history of lung cancer. | 18673580 |
| Carcinoma of lung | Epigenetic Alterations | By detecting these changes in global DNA methylation, CpGlobal may have a role as a barometer for the onset and development of lung cancer. | 18673580 |
| Prostate Cancer Pathway | Epigenetic Alterations | Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. | 18676839 |
| Prostate Cancer Pathway | Epigenetic Alterations | In summary, microRNA expression becomes altered with the development and progression of prostate cancer. | 18676839 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Lastly, we found evidence that some microRNAs are androgen-regulated and that tumor microRNAs influence transcript abundance of protein-coding target genes in the cancerous prostate. | 18676839 |
| Bladder Neoplasm | Epigenetic Alterations | Exposure to tobacco smoke is associated with increased DNA methylation at certain genes in both lung and bladder tumors. | 18676844 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | We sought to identify interactions in bladder cancer between DNA methylation and a history of smoking, along with any possible effect of aging. | 18676844 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | We measured DNA methylation in 342 transitional cell carcinoma tumors at BCL2, PTGS2 (COX2), DAPK, CDH1 (ECAD), EDNRB, RASSF1A, RUNX3, TERT, and TIMP3. | 18676844 |
| Carcinoma | Epigenetic Alterations | Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma. | 18677302 |
| Carcinoma, Ovarian Serous Adenocarcinoma | Epigenetic Alterations | Specifically, we show decreased p53 expression and downregulation of miR-195 and miR-497 from the microRNA cluster site at chromosome 17p13.1 in primary peritoneal carcinoma relative to ovarian serous carcinoma. | 18677302 |
| Malignant Neoplasms | Epigenetic Alterations | Recent work has shown differential expression of mature microRNAs in human cancers. | 18677302 |
| Carcinoma, Ovarian Serous Adenocarcinoma | Epigenetic Alterations | We characterized the alteration in expression of a select group of microRNAs in primary peritoneal carcinoma relative to matched cases of ovarian serous carcinoma. | 18677302 |
| Carcinoma, Ovarian Serous Adenocarcinoma, Neoplasms | Epigenetic Alterations | We provide definitive evidence that there is downregulation of a select group of microRNAs in tumours meeting Gynaecological Oncology Group criteria for primary peritoneal carcinoma relative to ovarian serous carcinoma. | 18677302 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is known to play an important role in gene transcription and alterations of methylation contribute to the development of certain disorders such as cancer and immunodeficiency. | 18683034 |
| S-Adenosylhomocysteine | Epigenetic Alterations | Our observations suggest that aberrant DNA methylation status reflected by increased plasma SAH concentration and decreased mRNA expression levels of DNMT3A and 3B are possibly involved in the pathogenesis of ITP although the precise mechanisms need further study. | 18683034 |
| Autoimmune Diseases, Lupus Erythematosus, Systemic, Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Recent years have found an increasing interest in the role of epigenetic modifications in the etiology of human autoimmune diseases, such as systemic lupus erythromatosus (SLE) and rheumatoid arthritis (RA). | 18683034 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | DNA methylation analysis revealed that the LZTS1 gene was frequently methylated in both cell lines and primary tumors from breast cancer, and the extent of DNA methylation was correlated with reduced expression of the gene. | 18686028 |
| TRPV6 gene | Epigenetic Alterations | These findings suggested that BMP-6 promoter methylation is likely to be a common epigenetic event at later stages of ATL and that the methylation profiles may be useful for the staging of ATL as well as for evaluation of the individual risk of developing the disease. | 18688853 |
| Primary malignant neoplasm | Epigenetic Alterations | Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer. | 18695884 |
| Neoplasms | Epigenetic Alterations | Many micro-RNAs (miR10a, miR21, miR145, miR212, miR339, miR361) responded to chemoradiotherapy in individual tumor samples, but there was profound intertumoral variability. | 18695884 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | This study was aimed at identifying a recurrence-associated epigenetic prognostic marker in patients with ESCC. | 18697202 |
| Imprinting (Psychology), Alloisoleucine | Epigenetic Alterations | Loss of imprinting (LOI) is an epigenetic alteration involving loss of parental origin-specific expression at normally imprinted genes. | 18701505 |
| Primary malignant neoplasm | Epigenetic Alterations | We further show that Igf2 LOI occurs with aging in histologically normal human prostate tissues and that this epigenetic alteration was more extensive in men with associated cancer. | 18701505 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | DNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection. | 18702824 |
| Breast Cancer Cell | Epigenetic Alterations | Epigenetic alterations are a hallmark of human cancer. | 18702824 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Indistinct DNA hypermethylation of CDH1 and SFN genes between tumoral and normal urinary bladder samples suggests that these epigenetic features are not suitable biomarkers for urinary bladder cancer. | 18702824 |
| Breast Carcinoma | Epigenetic Alterations | Given its important role in DNA methylation and synthesis, one-carbon metabolism may affect breast cancer mortality. | 18708404 |
| Russell-Silver syndrome | Epigenetic Alterations | Silver-Russell syndrome (SRS) is characterized by growth failure and dysmorphic features, and is frequently caused by hypomethylation of the paternally derived H19-DMR (epimutation). | 18709478 |
| Carcinoma, Colorectal Carcinoma | Epigenetic Alterations | These findings suggest that epigenetic changes in the DNA mismatch repair genes play important roles in the development of gastric and colorectal carcinomas and that the SNP of DNA repair genes have little influence on the occurrence of carcinoma in the elderly. | 18713157 |
| Glioblastoma | Epigenetic Alterations | Evaluation of histone acetylation levels showed that histone H3 is more acetylated in glioblastomas than normal brain tissue confirming the downregulation of HDAC mRNA in glioblastomas. | 18713462 |
| Neurodegenerative Disorders | Epigenetic Alterations | Translational regulation by miRNAs may represent a common mechanism underlying complex neurodegenerative disorders. | 18723524 |
| Somatic KIT Gene Mutation | Epigenetic Alterations | Clustering of these lesions in the proximal stomach, their close proximity, and the demonstration of different KIT mutations in individual lesions from the same patient point to the existence of distinct subsets of interstitial cells of Cajal with a higher propensity for different somatic KIT exon 11 mutations, possibly as a result of a field effect involving premutational epigenetic alterations or yet unidentified etiologic factors. | 18724245 |
| Primary malignant neoplasm | Epigenetic Alterations | As DNA methylation has been determined as an important diagnostic biomarker in cancer management, methods for the detection of quantitative DNA methylation which are high-throughput and low-cost are needed. | 18751375 |
| Colorectal Carcinoma, Neoplasms | Epigenetic Alterations | With this method, DNA methylation in the promoter of the APC tumour suppressor gene was quantified in a set of colorectal carcinoma samples. | 18751375 |
| Kidney Cancer pT1a TNM Finding v6 and v7 | Epigenetic Alterations | Prognostic role of global DNA-methylation and histone acetylation in pT1a clear cell renal carcinoma in partial nephrectomy specimens. | 18752633 |
| Aggressive behavior, pT1a Stage Finding | Epigenetic Alterations | The percentage of methylation was significantly higher in grades 3 and 4 (P = 0.033), whereas the percentage of histone acetylation was significantly lower (P = 0.023), suggesting therefore that these markers could correlate with tumour aggressiveness in pT1a RCC. | 18752633 |
| Fuhrman nuclear grade, Aggressive behavior, Renal Cell Carcinoma, Refractory Cytopenia of Childhood | Epigenetic Alterations | These epigenetic markers can give us interesting information about chromatin remodelling in RCCs; the percentage of global methylation increases with increasing Fuhrman grade, whereas histone acetylation decreases with increasing grade in small RCC; our results suggest that global hypermethylation and histone hypoacetylation can be assumed to be an early event in RCC and to correlate with tumour aggressiveness. | 18752633 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | In addition to silencing as a result of mutations, loss of heterozygosity, or classic genetic events, epigenetic modification symbolizes essential events during carcinogenesis and tumour development. | 18752633 |
| Breast Carcinoma | Epigenetic Alterations | Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer. | 18755890 |
| Breast Carcinoma | Epigenetic Alterations | In addition, the prognostic value of the candidate miRNAs was determined in ER(-)/LNN breast cancer. | 18755890 |
| Breast Carcinoma | Epigenetic Alterations | In conclusion, our work connects four miRNAs to breast cancer progression and to several distinct biological processes involved therein. | 18755890 |
| Neoplasms | Epigenetic Alterations | Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. | 18756266 |
| Neoplasms | Epigenetic Alterations | Downregulation of these miRNAs allows high levels of Hh-dependent gene expression leading to tumour cell proliferation. | 18756266 |
| Primary malignant neoplasm | Epigenetic Alterations | These findings identify a novel regulatory circuitry of the Hh signalling and suggest that misregulation of specific miRNAs, leading to its aberrant activation, sustain cancer development. | 18756266 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Aberrant DNA methylation of the transcription factor C/EBPalpha in acute myelogenous leukemia. | 18757096 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Our results provide further evidence for epigenetic dysregulation of C/EBPalpha in AML. | 18757096 |
| Autoimmune Diseases, Primary malignant neoplasm | Epigenetic Alterations | It is known that aberrant microRNA expression can play important roles in cancer, but the role of microRNAs in autoimmune diseases is only beginning to emerge. | 18759964 |
| Rheumatoid Arthritis | Epigenetic Alterations | Our data thus demonstrate that microRNA expression in rheumatoid arthritis peripheral blood mononuclear cells mimics that of synovial tissue/fibroblasts. | 18759964 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Epigenetic dysregulation of the Wnt signalling pathway in chronic lymphocytic leukaemia. | 18765431 |
| Colonic Neoplasms | Epigenetic Alterations | Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors. | 18767147 |
| Glioblastoma, Primary malignant neoplasm | Epigenetic Alterations | Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas--the most common type of adult brain cancer--and nucleotide sequence aberrations in 91 of the 206 glioblastomas. | 18772890 |
| Mismatch Repair Deficiency, Glioblastoma | Epigenetic Alterations | Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. | 18772890 |
| S100A4 protein, human, Primary malignant neoplasm | Epigenetic Alterations | Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. | 18772890 |
| Neoplasms | Epigenetic Alterations | Aberrant DNA methylation of 5-CpG islands located within gene promoters has been identified as a mechanism for transcriptional inactivation of tumor suppressor genes. | 18773859 |
| Cholangiocarcinoma | Epigenetic Alterations | Taken together, these results suggest that aberrant DNA methylation may contribute to the tumorigenesis of cholangiocarcinoma. | 18773859 |
| SF3B1 wt Allele, Leukemia, Myelocytic, Acute | Epigenetic Alterations | The pattern of results suggests that MDS was associated with the DNA methylation status and the risk for AML was associated with both the DNA synthesis and DNA methylation status. | 18774170 |
| Thymic Carcinoma, Thymoma | Epigenetic Alterations | We examined aberrant DNA methylation of DAP-K, p-16, MGMT and HPP1 genes in 26 thymomas and 6 thymic carcinoma to clarify the association between aberrant DNA methylation and clinicopathological features. | 18778870 |
| Behavior, THM gene, Thymic Carcinoma, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation was more frequent in thymic carcinoma than in thymoma, and the frequency of DNA methylation in thymic epithelial tumours is roughly parallel to their malignant behaviour. | 18778870 |
| Carcinogenesis, Carcinoma, Endometrioid | Epigenetic Alterations | To identify a DNA methylation signature of endometrioid carcinoma of the endometrium (EEC) in the early stages of endometrial carcinogenesis. | 18783461 |
| Neoplastic disease | Epigenetic Alterations | DNA methylation is a common molecular alteration in human neoplasia and can be detected easily in the bloodstream of patients. | 18784433 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic markers in sera, especially BRCA1/p16, may be more promising targets for the diagnosis of sporadic breast cancer than previous prognostic markers. | 18784433 |
| Carcinogenesis | Epigenetic Alterations | The epigenetic pathway of colorectal carcinogenesis has recently become the focus of attention. | 18795670 |
| Neoplasms | Epigenetic Alterations | The most common epigenetic change is the promoter hypermethylation of tumor suppressor genes. | 18795670 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Identification of an invasion and tumor-suppressing gene, Endoglin (ENG), silenced by both epigenetic inactivation and allelic loss in esophageal squamous cell carcinoma. | 18798555 |
| Neoplasms | Epigenetic Alterations | Both epigenetic methylation and allelic loss appear to contribute to ENG downregulation in tumor cells. | 18798555 |
| Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation plays important roles during multistage carcinogenesis in various human organs. | 18799028 |
| Gastric Adenocarcinoma | Epigenetic Alterations | Our data suggest that methylation of transmembrane protein containing epidermal growth factor and folistatin domains/hyperplastic polyposis 1 is present in the majority of gastric adenocarcinomas and in the surrounding tumoural-free area, indicating that this epigenetic change may point to a field effect in the gastric mucosa. | 18799374 |
| Liver carcinoma | Epigenetic Alterations | Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. | 18801366 |
| Metastasis, Neoplasms | Epigenetic Alterations | In addition to genetic alterations, epigenetic changes underlie tumor progression and metastasis. | 18801366 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Promoter methylation can silence tumor suppressor genes, and reactive oxygen species (ROS) promote DNA damage, although the relationship between ROS and epigenetic changes in cancer cells is not clear. | 18801366 |
| Carcinogenesis | Epigenetic Alterations | These findings provide novel mechanistic insights into epigenetic modulations induced by ROS in the process of carcinogenesis. | 18801366 |
| Prostate Cancer Pathway | Epigenetic Alterations | PCA3 is a prostate specific, nonprotein coding RNA that is over expressed in prostate cancer. | 18801539 |
| Neoplasms | Epigenetic Alterations | Since then, the concentration of free circulating plasma DNA has been studied as well as the genetic alterations and epigenetic alterations of tumour DNA of patients that suffer from various types of tumours. | 18804892 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. | 18812439 |
| miR-181b, human, MIR30A wt Allele, MIRLET7F1 wt Allele | Epigenetic Alterations | Nine miRNAs of hsa-miR-21, hsa-miR-365, hsa-miR-181b, hsa-let-7f, hsa-miR-155, hsa-miR-29b, hsa-miR-181d, hsa-miR-98, and hsa-miR-29c were observed to be up-regulated greater than twofold in BC compared with NAT, whereas seven miRNAs of hsa-miR-497, hsa-miR-31, hsa-miR-355, hsa-miR-320, rno-mir-140, hsa-miR-127 and hsa-miR-30a-3p were observed to be down-regulated greater than twofold. | 18812439 |
| Neoplasms | Epigenetic Alterations | The most significantly up-regulated miRNAs, hsa-mir-21 (miR-21), was quantitatively analyzed by TaqMan real-time PCR in 113 BC tumors. | 18812439 |
| Breast Carcinoma, Metastasis, Neoplasms, Best Case Imputation Technique | Epigenetic Alterations | This study could identify the differentiated miRNAs expression profile in BC and reveal that miR-21 overexpression was correlated with specific breast cancer biopathologic features, such as advanced tumor stage, lymph node metastasis, and poor survival of the patients, indicating that miR-21 may serve as a molecular prognostic marker for BC and disease progression. | 18812439 |
| Malignant Neoplasms | Epigenetic Alterations | To our knowledge, the present study is the first to demonstrate the epigenetic inactivation of TU3A in human cancers. | 18813805 |
| Neoplasms | Epigenetic Alterations | Our data showed that 10/49 (20.4%), 6/48 (12.5%) and 14/49 (28.6%) of tumors were methylated with a DNA methylation level >0.2 in CDKN2A, DPYD and MLH1, respectively. | 18813836 |
| Neoplasms | Epigenetic Alterations | The tumor DNA samples had unique DNA methylation patterns, which were high-degree and multiple-site methylation, but the normal DNA samples had no or a low-degree and dispersed single-site methylation. | 18813836 |
| Neoplasms | Epigenetic Alterations | In addition, an inverse correlation in those methylated tumors was observed between DNA methylation and RNA expression for MLH1 (RS=-0.62, P=0.003), but not for CDKN2A and DPYD. | 18813836 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm, Intraductal papillary mucinous neoplasm, Non-Neoplastic Pancreatic Disorder | Epigenetic Alterations | Identifying the alterations in DNA methylation that arise during intraductal papillary mucinous neoplasm development may facilitate the development of markers that could be used to differentiate intraductal papillary mucinous neoplasms from non-neoplastic pancreatic cystic lesions. | 18820670 |
| Intraductal papillary mucinous neoplasm | Epigenetic Alterations | Thus, aberrant DNA methylation increases with histologic grades of intraductal papillary mucinous neoplasm. | 18820670 |
| Carcinogenesis | Epigenetic Alterations | Our study provides evidence that epigenetic inactivation of EphA7 may be involved in prostate carcinogenesis. | 18821581 |
| Carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | As demethylating agents are now entering lung cancer trials, it is imperative to gain a greater insight into the potential reactivation of silent retrotransposons in order to advance for the clinical utilization of epigenetics in cancer therapy. | 18823011 |
| Benign neoplasm of bladder, Neoplasms | Epigenetic Alterations | Promoter hypermethylation in a panel of tumour suppressor genes involved in cell cycle control, apoptosis and DNA repair was analyzed in superficial bladder tumours in order to evaluate the suitability of epigenetic biomarkers for an earlier prediction of the aggressive course of the disease. | 18824877 |
| Breast Carcinoma, Carcinogenesis | Epigenetic Alterations | Since other Wnt signalling inhibitors have been reported to be targets of epigenetic inactivation in human breast cancer, we questioned if DKK3 expression is also epigenetically silenced during breast carcinogenesis and therefore might contribute to oncogenic Wnt signalling commonly found in this disease. | 18826564 |
| Malignant tumor of colon | Epigenetic Alterations | Utilising 649 colon cancers (stage I-IV) in two independent cohort studies, we quantified DNA methylation in eight CIMP-specific promoters (CACNA1G, CDKN2A (p16), CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1) as well as CHFR, HIC1, IGFBP3, MGMT, MINT1, MINT31, p14, and WRN by using MethyLight technology. | 18832519 |
| Keloid | Epigenetic Alterations | PAI-1-targeted interventions, such as small interfering RNA and lentiviral short hairpin RNA-containing microRNA sequence suppression reported here, may have therapeutic utility in the prevention of keloid scarring. | 18832570 |
| SF3B1 wt Allele, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. | 18832655 |
| SF3B1 wt Allele, Leukemia, Myelocytic, Acute | Epigenetic Alterations | In 184 patients with MDS and AML, DNA methylation microarray and high-density single nucleotide polymorphism array (SNP-A) karyotyping were used to assess the relative contributions of aberrant DNA methylation and chromosomal deletions to tumor-suppressor gene (TSG) silencing during disease progression. | 18832655 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | However, the ubiquity, extent, and correlation with disease progression suggest that aberrant DNA methylation is the dominant mechanism for TSG silencing and clonal variation in MDS evolution to AML. | 18832655 |
| Chronic inflammatory disorder, Ulcerative Colitis | Epigenetic Alterations | These findings expand the known roles of miRNAs, indicating that tissues from patients with UC, and possibly other chronic inflammatory diseases, have altered miRNA expression patterns. | 18835392 |
| Ulcerative Colitis | Epigenetic Alterations | MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. | 18835392 |
| Ulcerative Colitis | Epigenetic Alterations | Active UC was associated with the differential expression of 11 miRNAs; 3 were significantly decreased and 8 were significantly increased in UC tissues. | 18835392 |
| Breast Carcinoma | Epigenetic Alterations | To what extent epigenetic alterations of the APC gene may differ according to specific breast cancer phenotypes, remains to be elucidated. | 18841156 |
| Hematologic Neoplasms, Malignant neoplasm of liver, Neoplasms | Epigenetic Alterations | DLC1 (deleted in liver cancer 1), a tumor suppressor gene that encodes a RhoGTPase-activating protein, is recurrently downregulated or silenced in various solid tumors and hematological malignancies because of epigenetic modifications or genomic deletion. | 18923442 |
| Multiple Myeloma | Epigenetic Alterations | Given the myeloma cells sensitivity to the reactivation of DLC1 function, the potential for molecular targeted therapy of DLC1-mediated pathways as well as epigenetic therapies hold prospects. | 18923442 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Genome-wide microRNA expression profiling in renal cell carcinoma: significant down-regulation of miR-141 and miR-200c. | 18925646 |
| Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA-21 (miR-21) is considered an onco-microRNA given its abilities to suppress the actions of several tumor suppressor genes and to promote tumor cell growth, invasion and metastasis. | 18932017 |
| Neoplasms | Epigenetic Alterations | The expression of miR-21 in tumor samples was measured with a TaqMan microRNA assay using U6 as reference. | 18932017 |
| Breast Carcinoma | Epigenetic Alterations | The study supports the notion that miR-21 is an onco-microRNA for breast cancer. | 18932017 |
| Primary malignant neoplasm | Epigenetic Alterations | Here, the prognostic significance of this epigenetic marker with respect to severe 5-FU toxicity was assessed in 27 cancer patients receiving 5-FU based chemotherapy, including 17 patients experiencing severe toxic side effects following drug administration, none of which were carriers of a known deleterious DPYD mutation, and ten control patients. | 18937829 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic events in normal colonic mucosa surrounding colorectal cancer lesions. | 18938072 |
| Clinical Coordinator | Epigenetic Alterations | However, current data do not prove direct involvement of this epigenetic modification in the early stages of CRC. | 18938072 |
| Carcinogenesis, Colorectal Neoplasms | Epigenetic Alterations | Our results indicate that epigenetic changes in mucosa surrounding colorectal neoplastic lesions may describe a field cancerisation phenomenon that may occur previous to genetic alterations in early stages of carcinogenesis. | 18938072 |
| Primary malignant neoplasm | Epigenetic Alterations | A possible epigenetic regulation of the two isoenzymes of fructose 1,6-bisphosphatase (FBPase) was studied in liver, muscle, mamma, breast cancer and in different cancer cell lines. | 18938139 |
| Degenerative polyarthritis | Epigenetic Alterations | DNA methylation was lost at specific CpG sites in the ADAMTS-4 promoter in OA chondrocytes, suggesting that the increased gene expression was more than a simple up-regulation, but involved loss of DNA methylation at specific CpG sites, resulting in a heritable and permanent expression of ADAMTS-4 in OA chondrocytes. | 18941754 |
| melanoma | Epigenetic Alterations | Furthermore, treatment of C8161 and MeWo cells with 5-azacytidine, a DNA demethylating agent, induced the expression of PAX4, suggesting that DNA methylation repressed the PAX4 gene expression in human melanoma. | 18949370 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic inactivation of SFRP1 by methylation of its promoter CpG island has recently been reported in several types of cancers. | 18949430 |
| Squamous cell carcinoma | Epigenetic Alterations | Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus. | 18953329 |
| Primary malignant neoplasm | Epigenetic Alterations | Patterns of global histone modifications have been recently suggested as outcome predictors in cancer patients. | 18953329 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | To date, there has been no report on the prognostic significance of global histone modifications in esophageal squamous cell carcinoma. | 18953329 |
| Primary malignant neoplasm | Epigenetic Alterations | The RNA from 9 cancer specimens was compared to 4 normal specimens with real-time PCR using the TaqMan Array Human MicroRNA panel. | 18954897 |
| ovarian neoplasm | Epigenetic Alterations | The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. | 18954897 |
| ovarian neoplasm | Epigenetic Alterations | To determine the utility of serum miRNAs as biomarkers for epithelial ovarian cancer. | 18954897 |
| Primary malignant neoplasm | Epigenetic Alterations | Real-time PCR for the 21 individual miRNAs was performed on the remaining 19 cancer specimens and 11 normal specimens. | 18954897 |
| Primary malignant neoplasm | Epigenetic Alterations | Eight miRNAs of the original twenty-one were identified that were significantly differentially expressed between cancer and normal specimens using the comparative C(t) method. | 18954897 |
| Primary malignant neoplasm | Epigenetic Alterations | MiRNAs-21, 92, 93, 126 and 29a were significantly over-expressed in the serum from cancer patients compared to controls (p<.01). | 18954897 |
| ovarian neoplasm | Epigenetic Alterations | We demonstrate that the extraction of RNA and subsequent identification of miRNAs from the serum of individuals diagnosed with ovarian cancer is feasible. | 18954897 |
| Degenerative polyarthritis | Epigenetic Alterations | p21(WAF1/CIP1) was previously suggested to be down-regulated in OA chondrocytes and is known to be regulated by epigenetic modulation. | 18954998 |
| Admitting diagnosis | Epigenetic Alterations | Furthermore, up-regulation of AZGP1 mRNA in AD may be affected by chromatin remodeling by means of histone acetylation. | 18978557 |
| Neoplasms | Epigenetic Alterations | To determine whether AZGP1 expression in this subset of tumors might be affected by epigenetic mechanisms, low AZGP1-expressing A549 and SKLU1 AD cell lines were treated with TSA and 5-AZA. | 18978557 |
| Breast Carcinoma | Epigenetic Alterations | These data indicate that EGFR as well as HER2 are prognostic factors of worse clinical outcomes, whereas HER3 and HER4 gene transcription is associated with better prognosis in high-risk early breast cancer. | 18985033 |
| Degenerative polyarthritis | Epigenetic Alterations | Both primary and secondary OA were characterized by loss of aggrecan, formation of clones, and abnormal expression of the proteases that correlated with epigenetic DNA demethylation. | 18985702 |
| Breast Carcinoma | Epigenetic Alterations | Although clinical patient outcome was not associated with SFRP2 methylation, the high frequency of this epimutation and its putative specificity to neoplastic cells may qualify SFRP2 promoter methylation as a potential candidate screening marker helping to improve early breast cancer detection. | 18990230 |
| Breast Carcinoma | Epigenetic Alterations | Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer. | 18990230 |
| Breast Carcinoma | Epigenetic Alterations | The SFRP2 gene is a high-frequent target of epigenetic inactivation in human breast cancer. | 18990230 |
| Colonic Neoplasms | Epigenetic Alterations | Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. | 18992263 |
| Tetranitromethane, Metastasis, Liver carcinoma | Epigenetic Alterations | The low-expression or non-expression of NGX6 gene plays an important role in the gene transcription level in hepatocellular carcinoma.The expression of NGX6 gene is related with TNM staging and lymph node metastasis in hepatocellular carcinoma. | 19001737 |
| Colorectal Carcinoma | Epigenetic Alterations | METHOLODOLOGY/PRINCIPAL FINDINGS: DNA methylation at 16 CpG islands [the above 5 plus CDKN2A (p16), CHFR, CRABP1, HIC1, IGFBP3, MGMT, MINT1, MINT31, MLH1, p14 (CDKN2A/ARF) and WRN] was quantified in 904 colorectal cancers by real-time PCR (MethyLight). | 19002263 |
| Degenerative polyarthritis | Epigenetic Alterations | We have identified a number of differentially expressed miRNAs in late-stage human OA cartilage and bone. | 19008124 |
| Hollings Cancer Center | Epigenetic Alterations | Our results show that epigenetic silencing of Tip30 gene expression by CpG island DNA hypermethylation is associated with poor prognosis in patients with HCC. | 19010857 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNA profiling of patient-derived osteoarthritic cartilage in comparison to normal cartilage, revealed a 16 microRNA osteoarthritis gene signature. | 19011694 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay. | 19018278 |
| Clinical Coordinator | Epigenetic Alterations | Analysis of SEPT9 DNA methylation in plasma represents a straightforward, minimally invasive method to detect all stages of CRC with potential to satisfy unmet needs for increased compliance in the screening population. | 19018278 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | The epigenetic changes of TSGs are now recognized as a mechanism contributing to the development of chronic myeloid leukemia (CML). | 19018866 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Adequate intake of folate, methionine, riboflavin, and vitamin B-6 may prevent aberrant DNA methylation and thereby protect against colorectal cancer (CRC). | 19022960 |
| Malignant tumor of colon | Epigenetic Alterations | Using 643 colon cancers in two independent prospective cohorts, we quantified DNA methylation in repetitive long interspersed nucleotide element-1 (LINE-1) elements using pyrosequencing, which is a good indicator of global DNA methylation level. | 19033568 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome. | 19037089 |
| Carcinogenesis | Epigenetic Alterations | To clarify genome-wide DNA methylation profiles during multistage renal carcinogenesis, bacterial artificial chromosome array-based methylated CpG island amplification (BAMCA) was performed. | 19037089 |
| Cell of Claudius | Epigenetic Alterations | In individual patients, DNA methylation status in N was basically inherited by the corresponding clear cell RCC. | 19037089 |
| Hollings Cancer Center | Epigenetic Alterations | These results, thus, suggest that JNK1 plays important roles in the development of human HCC partially through the epigenetic mechanisms. | 19041150 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Epigenetic inactivation of galanin receptor 1 in head and neck cancer. | 19047085 |
| Squamous cell carcinoma of vulva | Epigenetic Alterations | These findings underscore the contribution of both genetic and epigenetic events to the underlying pathogenesis of squamous cell carcinoma of the vulva. | 19047905 |
| Primary malignant neoplasm | Epigenetic Alterations | Altered DNA methylation in cancer cells is characterized by focal CpG island hypermethylation and diffuse genomic hypomethylation. | 19048291 |
| Barrett Esophagus, Helicobacter pylori, Communicable Diseases | Epigenetic Alterations | Genetic or epigenetic alterations in Barretts esophagus (BE) with/without Helicobacter pylori (H. pylori) infection remain unclear. | 19048617 |
| Breast Carcinoma | Epigenetic Alterations | Novel genetic variants in microRNA genes and familial breast cancer. | 19048628 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA) plays an important role in tumorigenesis, but whether miRNA is a cancer predisposition factor or not is still unknown. | 19048628 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Considering the fact that miRNA regulates a number of tumor suppressor genes (TSGs) and oncogenes, genetic variations in miRNA genes could affect the levels of expression of TSGs or oncogenes and, thereby, cancer risk. | 19048628 |
| Breast Carcinoma | Epigenetic Alterations | To test this hypothesis, we screened genetic variants in 17 selected miRNA genes, which are predicted to regulate key breast cancer genes, in 42 patients with familial breast cancer. | 19048628 |
| Breast Carcinoma | Epigenetic Alterations | Our findings suggest that functional genetic variants in miRNA genes can potentially alter the regulation of key breast cancer genes. | 19048628 |
| Scleroderma | Epigenetic Alterations | Additionally, these data also imply that epigenetic factors, such as Dnmt1, may be involved in the maintenance of the scleroderma phenotype. | 19054252 |
| precancerous lesions | Epigenetic Alterations | Epigenetic changes of this type play undisputed roles in cell transformation when they involve genes that safeguard genome stability, and they can also be detected in precancerous lesions and seemingly normal peritumoral tissues. | 19060925 |
| Colorectal Carcinoma, Colorectal Cancer Pathway | Epigenetic Alterations | These findings paralleled immunohistochemical patterns of hMLH1 and MGMT protein loss in an independent series of 231 colorectal cancers and were consistent with current epigenetic profiles of colorectal cancer subsets. | 19060925 |
| Malignant Neoplasms | Epigenetic Alterations | They suggest the intriguing possibility that the epigenetic signatures of cancers may have early-stage, normal-tissue counterparts that reflect potentially important aspects of the initial carcinogenetic process. | 19060925 |
| Adenocarcinoma of pancreas | Epigenetic Alterations | The prevalence of mutant KRAS2, inactivation of TP53 and SMAD4, and aberrant DNA methylation of a seven-gene panel is similar in familial pancreatic adenocarcinomas as in sporadic pancreatic adenocarcinomas. | 19064568 |
| Pancreatic carcinoma, familial | Epigenetic Alterations | Genetic and epigenetic alterations of familial pancreatic cancers. | 19064568 |
| Malignant neoplasm of pancreas | Epigenetic Alterations | Little is known about the genetic and epigenetic changes that contribute to familial pancreatic cancers. | 19064568 |
| Endometrial Endometrioid Adenocarcinoma | Epigenetic Alterations | Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women. | 19065659 |
| Myometrial Invasion | Epigenetic Alterations | The expression of a sub-group of miRNAs was significantly correlated with clinico-pathological characteristics including stage, myometrial invasion, recurrence and lymph node involvement. | 19065659 |
| Waldenstrom Macroglobulinemia | Epigenetic Alterations | microRNA expression in the biology, prognosis, and therapy of Waldenstrom macroglobulinemia. | 19074725 |
| Malignant Neoplasms, Tumor Suppressor Genes, Neoplasms | Epigenetic Alterations | It is also known that miRNAs play a role in human cancers where they can act either as oncogenes, down-regulating tumor suppressor genes, or as onco-suppressors, targeting molecules critically involved in promotion of tumor growth. | 19074879 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer. | 19074899 |
| Late stage | Epigenetic Alterations | Finally, using miRNA microarray, we found that decreased let-7i expression was significantly associated with the shorter progression-free survival of patients with late-stage ovarian cancer (n = 72, P = 0.042). | 19074899 |
| ovarian neoplasm | Epigenetic Alterations | Our recent studies showed that miRNAs exhibit genomic alterations at a high frequency and their expression is remarkably deregulated in ovarian cancer, strongly suggesting that miRNAs are involved in the initiation and progression of this disease. | 19074899 |
| Heart failure | Epigenetic Alterations | Genome-wide histone methylation profile for heart failure. | 19077033 |
| Heart failure, Cardiac Hypertrophy | Epigenetic Alterations | Epigenetic alterations are implicated in the development of cardiac hypertrophy and heart failure, but little is known of which epigenetic changes in which regions of the genome play such a role. | 19077033 |
| Heart failure | Epigenetic Alterations | Our data collectively reveal global epigenetic changes in cardiac myocytes associated with heart failure. | 19077033 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic regulation of the TFPI-2 gene, through methylation of CpG islands, has been advocated in cancer. | 19081094 |
| Carcinogenesis | Epigenetic Alterations | DNA methylation is one of the major events in the early process of gastric carcinogenesis and it also occurs in non-neoplastic gastric mucosa. | 19082889 |
| Infection caused by Helicobacter pylori | Epigenetic Alterations | Our data suggest that MTHFR 677T carrier influences the risk of DNA methylation in gastric mucosa in the long-term outcome of the H. pylori infection. | 19082889 |
| Stomach Carcinoma | Epigenetic Alterations | We analyzed its epigenetic inactivation, biological effects, and prognostic significance in gastric cancer. | 19084528 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The epigenetic silencing of PMF1 by hypermethylation was tested in bladder cancer cells (n = 11) after azacytidine treatment. | 19088041 |
| Neoplasms | Epigenetic Alterations | Gene expression in tumours is regulated by environmental as well as genetic/epigenetic factors. | 19102008 |
| Neoplasms | Epigenetic Alterations | MiR-221 and miR-222 are two highly homologous microRNAs whose upregulation has been recently described in several types of human tumors, for some of which their oncogenic role was explained by the discovery of their target p27, a key cell cycle regulator. | 19107213 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Residual DNA methylation at remission is prognostic in adult Philadelphia chromosome-negative acute lymphocytic leukemia. | 19109226 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Pretreatment aberrant DNA methylation patterns are stable at time of relapse in acute lymphocytic leukemia (ALL). | 19109226 |
| Acute lymphocytic leukemia | Epigenetic Alterations | In conclusion, detection of epigenetic alterations allows the identification of patients with ALL with standard risk but with poor prognosis. | 19109226 |
| Breast Carcinoma | Epigenetic Alterations | In summary, the presented data demonstrate for the first time the reduced EFEMP1 expression on RNA and protein level in a substantial number of sporadic breast carcinomas and its correlation with epigenetic alterations. | 19115204 |
| Colorectal Neoplasms | Epigenetic Alterations | Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact. | 19117505 |
| Alzheimers Disease | Epigenetic Alterations | Epigenetic changes in Alzheimers disease: decrements in DNA methylation. | 19117641 |
| Admitting diagnosis | Epigenetic Alterations | We show, for the first time, neuronal immunoreactivity for all 10 of the epigenetic markers and factors, with highly significant decrements in AD cases. | 19117641 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome. | 19118007 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | We have added to the growing body of evidence that cellular epigenetic dysregulation is a critical mode of action for asbestos in the induction of pleural mesothelioma. | 19118007 |
| Malignant Neoplasms | Epigenetic Alterations | Importantly, these findings hold great promise for using epigenetic profiling in the diagnosis and prognosis of human cancers. | 19118007 |
| Carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors. | 19118009 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | Together, this study identifies aberrant DNA methylation patterns in lung cancer and thus exemplifies the mechanism by which environmental factors may interact with key genes involved in tumor suppression and contribute to lung cancer. | 19118009 |
| Huntington Disease | Epigenetic Alterations | The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntingtons disease. | 19118166 |
| Pathology, Neoplasms | Epigenetic Alterations | Phosphatase and tension homolog deleted on chromosome 10 (PTEN), a tumor suppressor, is frequently deficient in various pathologies due to mutation or epigenetic alterations. | 19118244 |
| Neoplasms | Epigenetic Alterations | PTEN promoter hypermethylation is a major epigenetic silencing mechanism leading to activation of angiogenesis in tumors. | 19118244 |
| Cerebrocostomandibular Syndrome | Epigenetic Alterations | We reported here for the first time the involvement of PTEN promoter methylation in CCMs, particularly in familial CCMs, suggesting this epigenetic alteration as a potential pathomechanism of CCMs. | 19118244 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | To investigate whether epigenetic silencing of sFRP is responsible for the observed Wnt activation in CML, we studied the methylation and mutational status of the sFRP1 promoter in 48 chronic phase CML patients. | 19118898 |
| Carcinogenesis | Epigenetic Alterations | Our findings add to increasing evidence that DNA methylation plays an important role even at an early stage of colorectal carcinogenesis. | 19124508 |
| Carcinogenesis | Epigenetic Alterations | Therefore, it could be suggested that hypermethylation of p16(INK4A) promoter is one of the epigenetic factors affecting the progress of sporadic breast carcinogenesis in Iranian patients. | 19125298 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma. | 19126652 |
| Neoplasms | Epigenetic Alterations | Among tumors, there were significant associations between specific DNA methylation profile classes and tobacco smoking and alcohol exposures. | 19126652 |
| Squamous cell carcinoma of the head and neck, Neoplasms | Epigenetic Alterations | We found that the etiologic heterogeneity of HNSCC is reflected in specific patterns of molecular epigenetic alterations within the tumors and that the DNA methylation profiles may hold clinical promise worthy of further study. | 19126652 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | Previous research has identified individual epigenetic alterations and, in some cases, the relationship of these alterations with carcinogen exposure or patient outcomes, suggesting that specific exposures give rise to specific types of molecular alterations in HNSCCs. | 19126652 |
| Neoplasms | Epigenetic Alterations | The overall pattern of epigenetic alteration could significantly distinguish tumor from normal head and neck epithelial tissues (P < 0.0001) more effectively than specific gene methylation events. | 19126652 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | The authors of this report hypothesized that environmental factors and lifestyle differences among various ethnic groups may differentially influence the epigenetic regulation of tumor suppressor genes in CRC. | 19127559 |
| Primary malignant neoplasm | Epigenetic Alterations | Genetic aberrations such as allelic imbalance (AI) and epigenetic changes such as promoter hypermethylation have been detected in circulating DNA of cancer patients. | 19131636 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | We hypothesized that circulating multimarker DNA assays detecting both genetic and epigenetic markers in serum would be useful in assessing PCa patients. | 19131636 |
| Osteosarcoma, Liver carcinoma | Epigenetic Alterations | MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma. | 19133651 |
| Hollings Cancer Center | Epigenetic Alterations | The results showed that among the 20 HCC samples analyzed, microRNA-101 was significantly down-regulated twofold or more (twofold to 20-fold) in 16 samples compared with the matching nontumoral liver tissues. | 19133651 |
| Hollings Cancer Center | Epigenetic Alterations | In in vitro Matrigel invasion and Transwell migration assays, enhanced microRNA-101 expression inhibited the invasion and migration of cultured HCC cells, respectively. | 19133651 |
| Hollings Cancer Center | Epigenetic Alterations | These findings suggest that microRNA-101 may play an important role in HCC. | 19133651 |
| Hollings Cancer Center | Epigenetic Alterations | MicroRNA-101, which is aberrantly expressed in HCC, could repress the expression of the FOS oncogene. | 19133651 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | Although there is emerging evidence that some microRNAs can function as oncogenes or tumor suppressors, the specific role of miRNA in human hepatocellular carcinoma (HCC) is unclear at this point. | 19133651 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNA) can act as oncogenes or tumor suppressors and modulate the expression of approximately one third of all human genes. | 19138993 |
| Combined Lung Small Cell Carcinoma and Lung Adenocarcinoma, Bronchioloalveolar Adenocarcinoma | Epigenetic Alterations | DNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components. | 19144441 |
| Adenocarcinoma | Epigenetic Alterations | Our results indicate the involvement of epigenetic alterations in the progression of adenocarcinoma with BAC components. | 19144441 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification. | 19144983 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Aberrant expression of microRNAs has been recently associated with chronic lymphocytic leukemia (CLL) outcome. | 19144983 |
| Stomach Carcinoma | Epigenetic Alterations | microRNA expression profile in undifferentiated gastric cancer. | 19148490 |
| Stomach Carcinoma | Epigenetic Alterations | The expression levels of 3 miRNAs (mir-34b, mir-34c and mir-128a) were significantly upregulated and those of 3 miRNAs (mir-128b, mir-129 and mir-148) were downregulated in undifferentiated gastric cancer tissue when compared with those of the paired normal tissues. | 19148490 |
| Stomach Carcinoma | Epigenetic Alterations | Our investigation provides a list of candidate miRNAs that may be associated with the prognosis in undifferentiated gastric cancer patients. | 19148490 |
| Primary malignant neoplasm | Epigenetic Alterations | Consequently, promoter hypermethylation, being the most important aberrant epigenetic characteristic, has been intensively investigated for its biomarker potential in this cancer type. | 19148529 |
| Neoplasms | Epigenetic Alterations | Tumor biopsies revealed the epigenetic silencing of MGMT in 42.5% (17 of 40) of patients and of TIMP3 in 40.5% (17 of 42) of cases. | 19148529 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | In conclusion, in this representative group of 46 patients with advanced HNSCC treated by radiotherapy only, the epigenetic silencing of TIMP3 and CDH1 predicted a better outcome. | 19148529 |
| Breast Carcinoma | Epigenetic Alterations | This research demonstrates the potential for gene-body epigenetic misregulation of ATM and other cancer-related genes in peripheral blood DNA that may be useful as a novel marker to estimate breast cancer risk. | 19153073 |
| Bladder Neoplasm | Epigenetic Alterations | Our data suggest that epigenetic alterations may have an important role in the mechanism of bladder tumor recurrence. | 19157440 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | MicroRNA-143 as a tumor suppressor for bladder cancer. | 19157460 |
| Malignant neoplasm of urinary bladder, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | miRNA profiling of human bladder cancer and matched normal urothelial epithelium controls revealed that 37 miRNAs were up-regulated and 38 were down-regulated in cancer tissues, of which the expression of miRNA-143 was 13.7 times lower in tumor than in the matched control. | 19157460 |
| Transitional cell carcinoma of bladder, Neoplasms | Epigenetic Alterations | miRNA-143 may function as a tumor suppressor in bladder transitional cell carcinoma. | 19157460 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | miRNAs are differentially expressed in bladder cancer tissues. | 19157460 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | miR-21 and 221 were overexpressed in glioma samples, whereas miRNA 181b was downregulated compared with normal brain tissue. | 19159078 |
| Glioma, Neoplasms | Epigenetic Alterations | miRNA-21 was hyperexpressed in all tumor samples whereas higher levels of miRNA-221 were found in high-grade gliomas. | 19159078 |
| Neoplasms | Epigenetic Alterations | Recent evidence indicates that miRNAs can function both as tumor suppressors and as oncogenes. | 19159078 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | The different expression pattern observed in tumors at different stages of malignancy is probably dependent on the cell-specific repertoire of target genes of tumors sharing different molecular pathways activity and suggests miRNAs may have also a place in diagnosis and staging of brain tumors. | 19159078 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Complete consistency in the correlation between both histone marks, the presence of DNA methylation around these miRNAs, and their expression patterns was confirmed in the six ALL cell lines. | 19164206 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Methylation status (methylation-specific polymerase chain reaction [PCR]) and expression (quantitative PCR) of miRNAs showing a pattern of histone modifications linked to a closed chromatin structure were analyzed in a panel of six ALL cell lines and in 353 ALL patients. | 19164206 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Epigenetic regulation of microRNAs in acute lymphoblastic leukemia. | 19164206 |
| Acute lymphocytic leukemia | Epigenetic Alterations | A total of 65% of the ALL samples had at least one miRNA methylated (methylated group). | 19164206 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Aberrant miRNA methylation is a common phenomenon in ALL that affects the clinical outcome of these patients. | 19164206 |
| Acute lymphocytic leukemia | Epigenetic Alterations | To identify microRNAs (miRNAs) epigenetically regulated in acute lymphoblastic leukemia (ALL). | 19164206 |
| MEN1 wt Allele | Epigenetic Alterations | To identify alterations underlying this defect, we searched for disruption and epigenetic silencing of the MEN1 gene. | 19170121 |
| Stomach Carcinoma | Epigenetic Alterations | DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients. | 19170207 |
| Primary malignant neoplasm | Epigenetic Alterations | However, the relationship between DNA methylation and the past lifestyle in cancer patients remains largely unknown. | 19170207 |
| Hepatitis B, Hepatitis C, Liver carcinoma | Epigenetic Alterations | Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. | 19173277 |
| Communicable Diseases, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA) plays an important role in the pathology of various diseases, including infection and cancer. | 19173277 |
| Hepatitis C, Hepatobiliary Disorder | Epigenetic Alterations | Detailed analysis of the differentially expressed miRNA revealed two types of miRNA, one associated with HBV and HCV infections (n = 19), the other with the stage of liver disease (n = 31). | 19173277 |
| Hollings Cancer Center | Epigenetic Alterations | Out of the 31 miRNAs associated with disease state, 17 were down-regulated in HCC, which up-regulated cancer-associated pathways such as cell cycle, adhesion, proteolysis, transcription, and translation; 6 miRNAs were up-regulated in HCC, which down-regulated anti-tumor immune response. | 19173277 |
| Hepatitis C, Hepatobiliary Disorder | Epigenetic Alterations | miRNAs are important mediators of HBV and HCV infection as well as liver disease progression, and therefore could be potential therapeutic target molecules. | 19173277 |
| Lynch Syndrome | Epigenetic Alterations | Large genomic rearrangements and germline epimutations in Lynch syndrome. | 19173287 |
| Mutation-Negative Lynch Syndrome, Lynch Syndrome | Epigenetic Alterations | Large genomic deletions (mainly MSH2) and germline epimutations (MLH1) together explain a significant fraction of point mutation-negative families suspected of Lynch syndrome and are associated with characteristic clinical and family features. | 19173287 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | To investigate the methylation frequencies of multiple tumor suppressor genes (TSGs) in hepatocellular carcinoma (HCC) and the clinical implication of aberrant DNA methylation in molecular carcinogenesis of HCC. | 19173828 |
| Liver carcinoma | Epigenetic Alterations | Different frequency of methylation in hepatocellular carcinomas, adjacent liver tissues and cirrhotic livers implies that epigenetic alteration in the hepatocellular carcinogenesis may be a gradually progressive process. | 19173828 |
| Stomach Carcinoma | Epigenetic Alterations | Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. | 19175831 |
| Stomach Carcinoma | Epigenetic Alterations | The global miRNA expression profile of gastric cancer has not been reported. | 19175831 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in carcinogenesis. | 19175831 |
| Stomach Carcinoma, MIR20A gene | Epigenetic Alterations | The most highly expressed miRNAs in gastric cancer tissues were miR-20b, miR-20a, miR-17, miR-106a, miR-18a, miR-21, miR-106b, miR-18b, miR-421, miR-340*, miR-19a and miR-658. | 19175831 |
| Stomach Carcinoma | Epigenetic Alterations | To our knowledge, this is the first report about these miRNAs associated with gastric cancer. | 19175831 |
| Stomach Carcinoma | Epigenetic Alterations | This new information may suggest the potential roles of these miRNAs in the diagnosis of gastric cancer. | 19175831 |
| Primary malignant neoplasm | Epigenetic Alterations | To identify a better set of DNA methylation markers to detect superficial, low grade cancer cell in urine sediment for improving cancer treatment, morbidity, and mortality. | 19181545 |
| liposarcoma | Epigenetic Alterations | Epigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma. | 19186005 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer develops through genetic, epigenetic, and environmental events that result in uncontrolled cell proliferation. | 19190129 |
| Primary malignant neoplasm | Epigenetic Alterations | Transformation of normal epithelium into cancer cells involves epigenetic and genetic changes and modifications in nuclear structure and tissue architecture. | 19193410 |
| Carcinogenesis, Metastasis | Epigenetic Alterations | These results suggest that the Syk gene is frequently inactivated during oral carcinogenesis and that an epigenetic mechanism may regulate loss of expression possibly leading to metastasis. | 19195024 |
| Opisthorchis Viverrini-Related Cholangiocarcinoma | Epigenetic Alterations | In conclusion, mechanisms of inactivation of p14(ARF), p15(INK4b), and p16(INK4a) in liver fluke-related cholangiocarcinoma are preferentially different, by which epigenetic event being the main mechanism of p14(ARF), whereas p16(INK4a) and p15(INK4b) inactivation occurs through genetic and both genetic and epigenetic events, respectively. | 19200577 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening. | 19201770 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) have been shown to offer great potential in the diagnosis of cancer. | 19201770 |
| Clinical Coordinator | Epigenetic Alterations | All the five miRNAs were validated on the plasma of 25 patients with CRC and 20 healthy controls. | 19201770 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNAs expressed during lung cancer development are expressed in human pseudoglandular lung embryogenesis. | 19209007 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) play a role during mouse embryonic development and are also important in carcinogenesis. | 19209007 |
| Carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | Our study lends support to the model of cancer as an alteration of normal development, as many miRNAs were similarly expressed in early human lung development and stage I-II of lung cancer development. | 19209007 |
| Malignant neoplasm of gastrointestinal tract | Epigenetic Alterations | These epigenetic changes create a distinct CIMP pattern that has been linked to recurrence and survival in gastrointestinal cancers. | 19223509 |
| melanoma | Epigenetic Alterations | Because epigenetic inactivation of TRGs also has been shown in malignant melanoma, we hypothesized the existence of a clinically significant CIMP in cutaneous melanoma progression. | 19223509 |
| Neoplasms | Epigenetic Alterations | Aberrant DAPK methylation in tumor tissues is significantly higher compared with matching normal esophageal tissues, suggesting a fundamental role of this epigenetic alteration in the pathogenesis of this disease. | 19224282 |
| Neoplasms | Epigenetic Alterations | Aberrant methylation of the promoter is an alternative epigenetic change in genetic mechanisms, leading to tumor suppressor gene inactivation. | 19224462 |
| Myofibrillar Myopathy | Epigenetic Alterations | These findings indicate that TDP-43 not only is another protein accumulated in myofibrillar myopathies, sIBM, and IBMPFD but also likely has a role through altered microRNA processing in the abnormal protein production, modification, and accumulation in protein aggregate myopathies. | 19225410 |
| Malignant Neoplasms, Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy. | 19228262 |
| Non-Malignant | Epigenetic Alterations | Nevertheless, malignant and non-malignant tissue could clearly be differentiated by their microRNA profile. | 19228262 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Only few data are available on microRNAs in clear cell renal cell carcinoma (ccRCC). | 19228262 |
| Neoplasms | Epigenetic Alterations | No significant associations between these differentially expressed microRNAs and the clinico-pathological factors tumour stage, tumour grade and survival rate were found. | 19228262 |
| Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation of the PITX2 gene promoter region is a strong independent prognostic marker of biochemical recurrence in patients with prostate cancer after radical prostatectomy. | 19233404 |
| Prostate Cancer Pathway | Epigenetic Alterations | We evaluated DNA methylation markers for prostate cancer prognosis. | 19233404 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Deoxyribonucleic acid (DNA) methylation of tumor origin can be detected in the serum/plasma of cancer patients. | 19240607 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Clinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer. | 19242066 |
| Congenital MeSH qualifier | Epigenetic Alterations | Furthermore, LOI of IGF2 was not associated with age, suggesting an inherited or congenital epigenetic event. | 19242102 |
| Colorectal Neoplasms | Epigenetic Alterations | The relationship between gene-specific DNA methylation in leukocytes and normal colorectal mucosa in subjects with and without colorectal tumors. | 19258481 |
| Carcinogenesis | Epigenetic Alterations | We suggest that the FHIT gene may be turned off in lung carcinogenesis via other genetic or epigenetic mechanisms rather than mutations. | 19267103 |
| Stomach Carcinoma | Epigenetic Alterations | In gastric cancer (GC), global and gene-specific DNA methylation changes have been demonstrated to occur. | 19267258 |
| Skin lesion | Epigenetic Alterations | The increased DNA methylation associated with As exposure previously observed, and confirmed among controls in this study, may be an adaptive change because hypomethylation of leukocyte DNA is associated with increased risk for skin lesions. | 19270796 |
| Adenocarcinoma | Epigenetic Alterations | High-throughput microarray was used to measure microRNA expression levels in 122 adenocarcinoma and squamous NSCLC samples. | 19273703 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | A microRNA-based qRT-PCR assay that measures expression of hsa-miR-205 reached sensitivity of 96% and specificity of 90% in the identification of squamous cell lung carcinomas in an independent blinded validation set. | 19273703 |
| Venous Invasion, Metastasis | Epigenetic Alterations | Specifically, patients with lymph node metastasis or venous invasion showed significantly high expression of microRNA-21. | 19276261 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Here, we show for the first time that a DNA methylation-based surrogate marker can serve as a predictor of disease recurrence in colorectal cancer. | 19282772 |
| Colorectal Cancer Pathway | Epigenetic Alterations | CpG island hypermethylation is a common epigenetic event in colorectal cancer. | 19282772 |
| Neoplasms | Epigenetic Alterations | In situ hybridization for the most differentially expressed miRNAs was performed to show miRNA expression in tumor cells, but not in background cells. | 19287466 |
| Lymphoma | Epigenetic Alterations | Recent studies have shown that certain non-coding short RNAs, called miRNAs, play an important role in diffuse large B-cell lymphomas. | 19287466 |
| Lymphoma | Epigenetic Alterations | No significant differences were seen between germinal center and non-germinal center diffuse large B-cell lymphomas in either the total or the nodal group for any of the 15 miRNAs. | 19287466 |
| Malignant Neoplasms | Epigenetic Alterations | It is becoming increasingly clear that altered miRNA expression correlates with the pathogenesis of cancers. | 19287964 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Over- and under-expressed microRNAs in human colorectal cancer. | 19287964 |
| Carcinogenesis, Colorectal Carcinoma | Epigenetic Alterations | We identified miRNAs that were overexpressed or under-expressed in colorectal cancers and which may be correlated with colorectal carcinogenesis. | 19287964 |
| Breast Cancer Cell, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are a class of small noncoding RNA genes found to be abnormally expressed in several types of cancer, suggesting a role in the pathogenesis of human cancer. | 19289371 |
| Carcinoma of lung | Epigenetic Alterations | Exosomal microRNA: a diagnostic marker for lung cancer. | 19289371 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | The mean miRNA concentration was 158.6 ng/mL (95% CI, 145.7-171.5) for the lung adenocarcinoma group versus 68.1 ng/mL (95% CI, 57.2-78.9) for the control group (P < .001). | 19289371 |
| Neoplasms | Epigenetic Alterations | Comparisons between peripheral circulation miRNA-derived exosomes and miRNA-derived tumors indicated that the miRNA signatures were not significantly different. | 19289371 |
| Carcinoma of lung, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | The significant difference in total exosome and miRNA levels between lung cancer patients and controls, and the similarity between the circulating exosomal miRNA and the tumor-derived miRNA patterns, suggest that circulating exosomal miRNA might be useful as a screening test for lung adenocarcinoma. | 19289371 |
| AJCC tumor staging, Adenocarcinoma of lung (disorder), Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | We evaluated the circulating levels of tumor exosomes, exosomal small RNA, and specific exosomal miRNAs in patients with and without lung adenocarcinoma, correlating the levels with the American Joint Committee on Cancer (AJCC) disease stage to validate it as an acceptable marker for diagnosis and prognosis in patients with adenocarcinoma of the lung. | 19289371 |
| Breast Carcinoma | Epigenetic Alterations | Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. | 19290006 |
| Lobular Neoplasia | Epigenetic Alterations | Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. | 19294736 |
| AKAP13 wt Allele | Epigenetic Alterations | We thus propose that epigenetic silencing represents the first of the two hits required to silence both CDH1 alleles for LBC to develop. | 19294736 |
| AKAP13 wt Allele | Epigenetic Alterations | Because promoter methylation is in principle reversible, our findings suggest that chemoprevention of LBC by epigenetic drugs should be feasible. | 19294736 |
| Cholangiocarcinoma | Epigenetic Alterations | MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. | 19296468 |
| Multiple Myeloma | Epigenetic Alterations | Epigenetic dysregulation of secreted Frizzled-related proteins in multiple myeloma. | 19299079 |
| Malignant Neoplasms | Epigenetic Alterations | It is thought that altered microRNA (miRNA) expression due to various mechanisms plays a critical role in the pathogenesis of most human cancers. | 19306352 |
| Multiple Myeloma, Morular Metaplasia of the Endometrium | Epigenetic Alterations | To date there is little evidence concerning miRNA expression in multiple myeloma (MM). | 19306352 |
| Neoplasms | Epigenetic Alterations | We identified 16 miRNAs mapped to chromosomal regions frequently involved in numerical imbalances in MM, whose expression significantly correlated with the CN of the corresponding miRNA genes; among these, miR-22 expression was also affected by chromosome arm 17p loss in a representative panel of primary MM tumors. | 19306352 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Valproic acid is a clinically relevant HDAC inhibitor, and PBMCs may serve as a surrogate for tumor histone acetylation in solid tumor malignancies. | 19318486 |
| Malignant neoplasm of gastrointestinal tract | Epigenetic Alterations | microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells. | 19318487 |
| Neoplasms | Epigenetic Alterations | Recent evidence has shown that some miRNAs can act as oncogenes or tumor suppressors. | 19318487 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Expression of 250 human mature miRNAs was measured by real-time PCR on paraffin-embedded tumor samples of 21 patients with gastric cancer stage III uniformly treated with surgical resection followed by chemoradiation. | 19318487 |
| Pancreatic carcinoma, Neoplasms | Epigenetic Alterations | let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression. | 19323605 |
| Neoplasms | Epigenetic Alterations | Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation, K-ras expression, and mitogen-activated protein kinase activation, but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA. | 19323605 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs are potent inhibitors of protein translation, and aberrantly expressed in many cancers. | 19323605 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Applying the model to population-based cancer registry data worldwide, 2 biologically relevant estimates are derived, namely the proportion of susceptible individuals and the number of genetic and epigenetic events required for the tumor to develop. | 19329819 |
| NCI CTEP SDC Oligodendroglial Tumors Sub-Category Terminology | Epigenetic Alterations | Correlation among pathology, genetic and epigenetic profiles, and clinical outcome in oligodendroglial tumors. | 19330828 |
| Oligodendroglial Neoplasm, Neoplasms | Epigenetic Alterations | Recent studies have revealed a correlation between specific genetic changes, such as loss of chromosome 1p and 19q, and sensitivity of oligodendroglial neoplasm to radiotherapy and chemotherapy; epigenetic changes also play an important role in some tumors. | 19330828 |
| Primary malignant neoplasm | Epigenetic Alterations | To assess the medical applicability of CpG methylation as molecular markers for cancer diagnosis, we established a new system to determine DNA methylation based on TaqMan PCR combined with a methyl-binding-domain polypeptide 2. | 19332050 |
| Disease | Epigenetic Alterations | A role of microRNA, which are approximately 22-nucleotide noncoding RNAs, has recently been recognized in human diseases. | 19333945 |
| Degenerative polyarthritis | Epigenetic Alterations | Expression of MicroRNA-146a in osteoarthritis cartilage. | 19333945 |
| melanoma, Neoplasms | Epigenetic Alterations | The expression of RUNX3 mRNA and miR-532-5p (microRNA) was assessed in melanoma lines and in primary and metastatic melanoma tumors. | 19336521 |
| Neoplasms | Epigenetic Alterations | Aberrant DNA methylation in thymic epithelial tumors. | 19340654 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation plays a critical role in the development and progression of many types of cancer. | 19340654 |
| Primary malignant neoplasm | Epigenetic Alterations | Cancer cells exhibit alterations in histone modification patterns at individual genes and globally at the level of single nuclei in individual cells. | 19349354 |
| Malignant Neoplasms | Epigenetic Alterations | Global levels of histone modifications predict prognosis in different cancers. | 19349354 |
| Neoplasms | Epigenetic Alterations | The predictive power of these histone modifications was independent of tissue-specific clinicopathological variables, the proliferation marker Ki-67, or a p53 tumor suppressor mutation. | 19349354 |
| aggressive cancer | Epigenetic Alterations | Chromatin immunoprecipitation experiments indicated that the lower cellular levels of histone modifications in more aggressive cancer cell lines correlated with lower levels of modifications at DNA repetitive elements but not with gene promoters across the genome. | 19349354 |
| Adenocarcinoma, aggressive cancer | Epigenetic Alterations | Our results suggest that lower global levels of histone modifications are predictive of a more aggressive cancer phenotype, revealing a surprising commonality in prognostic epigenetic patterns of adenocarcinomas of different tissue origins. | 19349354 |
| Neoplastic disease | Epigenetic Alterations | Epigenetic inactivation of O(6)-methylguanine-DNA methyltransferase has been found in human neoplasia and is considered one of the implicated factors in chemoresistance. | 19356788 |
| Pathology | Epigenetic Alterations | Impaired miRNA target binding resulting from SNPs within mRNA target sites has been shown to lead to pathologies associated with dysregulated gene expression. | 19363479 |
| hearing impairment, Autosome | Epigenetic Alterations | Here we show that point mutations in the seed region of miR-96, a miRNA expressed in hair cells of the inner ear, result in autosomal dominant, progressive hearing loss. | 19363479 |
| Malignant Neoplasms | Epigenetic Alterations | Human microRNA-141 (miR-141), a member of the miR-200 family, has been reported to be associated with various human malignancies. | 19363643 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | We previously reported the epigenetic silencing of paternally expressed gene 3 (PEG3) in glioma cell lines. | 19367087 |
| Glioblastoma Multiforme | Epigenetic Alterations | The lower gene expression, which suggested epigenetic silencing of PEG3, was confirmed statistically in glioblastoma using quantitative reverse-transcription polymerase chain reaction. | 19367087 |
| Breast Cancer Cell | Epigenetic Alterations | Aberrations in the DNA methylation patterns are currently recognized as a hallmark of human cancer. | 19368954 |
| Coronary Artery Disease | Epigenetic Alterations | Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease. | 19371267 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | The characterization of miRNA profiles in human tumors is crucial for the understanding of carcinogenesis processes, finding of new tumor markers, and discovering of specific targets for the development of innovative therapies. | 19372056 |
| Dementia, Discordance | Epigenetic Alterations | Neuropathological discordance in type of dementia among monozygotic pairs hints at environmental or epigenetic factors playing a role in Lewy body pathology. | 19372291 |
| Stomach Carcinoma | Epigenetic Alterations | Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes. | 19375421 |
| Carcinogenesis, Stomach Neoplasms | Epigenetic Alterations | Aberrant DNA methylation is an early and frequent process in gastric carcinogenesis and could be useful for detection of gastric neoplasia. | 19375421 |
| Stomach Carcinoma | Epigenetic Alterations | Additionally, we have developed a new method for gastric cancer detection by DNA methylation in gastric washes. | 19375421 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Identification of novel microRNA targets based on microRNA signatures in bladder cancer. | 19378336 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | To identify miRNAs that have a tumor suppressive function in bladder cancer (BC), 156 miRNAs were screened in 14 BCs, 5 normal bladder epithelium (NBE) samples and 3 BC cell lines. | 19378336 |
| Growth retardation, Neoplasms | Epigenetic Alterations | In addition, significant decreases in cell growth were observed after transfection of 3 miRNAs and si-KRT7 in KK47, suggesting that miR-30-3p, miR-133a and miR-199a* may have a tumor suppressive function through the mechanism underlying transcriptional repression of KRT7. | 19378336 |
| Lupus Erythematosus | Epigenetic Alterations | IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation. | 19380809 |
| Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | From normal epithelium to DCIS, there was a marked reduction in histone acetylation (P < 0.0001). | 19383825 |
| Peripheral Blood Stem Cells, Seizures | Epigenetic Alterations | The upregulation of DNMT-1 and to a lesser extent that of DNMT-3a mRNA in PBL of SZP supports the concept that this readily available peripheral cell type can express an epigenetic variation of specific biomarkers relevant to SZ morbidity. | 19386473 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Our results indicate a function of the epigenetic regulation of the Wnt pathway in predicting relapse in a subgroup of AML patients. | 19387464 |
| Neoplasms | Epigenetic Alterations | Differentially expressed miRNAs were found in tumor samples compared with normal sample. | 19396864 |
| Neurofibromatosis 2 | Epigenetic Alterations | Target genes for these miRNAs include the most frequently affected genes in MM such as CDKN2A, NF2, JUN, HGF, and PDGFA. | 19396864 |
| Malignant Neoplasms, Squamous cell carcinoma, SERPINB3 wt Allele | Epigenetic Alterations | Altered microRNA (miRNA) expression profiles have been observed in numerous malignancies, including oral squamous cell carcinoma (OSCC). | 19396866 |
| SERPINB3 wt Allele, Loss | Epigenetic Alterations | We hypothesize that the expression of miRNAs mapping to 11q are altered in OSCC because of loss or amplification of chromosomal material, and that this contributes to the development and progression of OSCC. | 19396866 |
| Stomach Carcinoma, Carcinogenesis | Epigenetic Alterations | DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis. | 19399343 |
| Stomach Carcinoma | Epigenetic Alterations | DNA methylation identified subgroups of diffuse type gastric cancer. | 19399343 |
| CDISC SDTM Lesion Complexity Terminology | Epigenetic Alterations | Micro-RNA (miRNA) mediated regulation of messenger RNA (mRNA) complexity in the central nervous system (CNS) is emerging as a critical factor in the control of CNS-specific gene expression during development, plasticity, aging and disease. | 19406203 |
| Leukocyte adhesion deficiency type 1 | Epigenetic Alterations | The results suggest (a) that unless specifically stabilized, certain brain-enriched miRNAs represent a rapidly executed signaling system employing highly transient effectors of CNS gene expression, and (b) that in AD temporal lobe neocortex specific brain miRNAs are significantly up-regulated in abundance and strongly correlate with the presence of AD-type neuropatholgical change. | 19406203 |
| Neoplasms | Epigenetic Alterations | ELISA, real-time qPCR and immunocytochemical staining demonstrated that adenoviral-vector based siRNA decreased angiogenin mRNA level and protein secretion, and inhibited angiogenin nuclear expression in A549 cells, resulting in marked inhibition on ribosomal RNA transcription, in vitro cell proliferation, soft agar colony formation, and xenograft tumor proliferation and angiogenesis. | 19423182 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer. | 19432961 |
| Breast Carcinoma | Epigenetic Alterations | Expression profiling of 453 miRNAs was performed in 29 early-stage breast cancer specimens. | 19432961 |
| Breast Carcinoma | Epigenetic Alterations | The association of specific miRNAs with ER, PR and HER2/neu status indicates a role for these miRNAs in disease classification of breast cancer. | 19432961 |
| Carcinogenesis | Epigenetic Alterations | TFPI2 belongs to the recently described group of embryonic cell Polycomb group (PcG)-marked genes that may be predisposed to aberrant DNA methylation in early stages of colorectal carcinogenesis. | 19435926 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Decreased expression of microRNA-143 and -145 in human gastric cancers. | 19439999 |
| Stomach Carcinoma | Epigenetic Alterations | The growth inhibitory effect was estimated by the transfection of human gastric cancer cells with the miRNA. | 19439999 |
| Neoplasms | Epigenetic Alterations | Downregulation of specific microRNAs (miRNAs) occurs in human tumors, which suggests a function for miRNAs in tumor suppression. | 19439999 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | Tumor microRNA expression patterns associated with resistance to platinum based chemotherapy and survival in ovarian cancer patients. | 19446316 |
| Neoplasms | Epigenetic Alterations | Seven microRNAs were found to be significantly differentially expressed in tumors from platinum-sensitive vs. platinum-resistant patients (p<0.05). | 19446316 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer. | 19446359 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | expressions of mature miRNAs, mir-21 and mir-155, were examined by real-time reverse transcription polymerase chain reaction (RT-PCR) and normalized to that of control miRNA, U6B, in sputum of 23 patients with NSCLC and 17 cancer-free subjects. | 19446359 |
| Carcinoma of lung | Epigenetic Alterations | The measurement of altered miRNA expression in sputum could be a useful noninvasive approach for the diagnosis of lung cancer. | 19446359 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNAs (miRNAs) are small regulatory RNAs that are frequently dysregulated in lung cancer and have shown promise as tissue-based markers for its prognostication. | 19446359 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer. | 19448674 |
| Upper aerodigestive tract | Epigenetic Alterations | We identified PLCD1 as a downregulated gene in aerodigestive carcinomas through expression profiling and epigenetic characterization. | 19448674 |
| Stomach Carcinoma, Carcinogenesis, Neoplasms | Epigenetic Alterations | Thus, epigenetic inactivation of PLCD1 is common and tumor-specific in gastric cancer, and PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis. | 19448674 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The effects of folate supplementations were analyzed on the global DNA methylation status, the methylation status of DNA repeat element, the sensitivity of temozolomide-induced apoptosis, and the proliferation index of glioma cells. | 19451595 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Finally, we show that the folate-induced DNA methylation limits proliferation and increases the sensitivity to temozolomide-induced apoptosis in glioma cells through methylation of the genes implicated in these processes (PDGF-B, MGMT, survivin, and bcl-w). | 19451595 |
| Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation biomarkers of prostate cancer: confirmation of candidates and evidence urine is the most sensitive body fluid for non-invasive detection. | 19459176 |
| Malignant Neoplasms | Epigenetic Alterations | Polymorphisms of the DNMT3B gene may influence its activity on DNA methylation in several cancers, thereby modulating susceptibility to tumorigenesis. | 19465161 |
| Primary malignant neoplasm | Epigenetic Alterations | New therapeutic agents, such as DNA methylation inhibitors, could be useful against this dramatic cancer. | 19465885 |
| Liver carcinoma | Epigenetic Alterations | Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression. | 19472311 |
| Liver neoplasms | Epigenetic Alterations | Moreover, we show that overexpression of this miRNA is transcribed by nuclear factor kappa B (NF-kappaB) and favors liver tumor cell invasive and metastatic behavior. | 19472311 |
| Malignant neoplasm of esophagus | Epigenetic Alterations | The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. | 19472401 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Esophageal squamous cell carcinomas (ESCCs) tend to have multiple primary lesions, and it is believed that they arise from background mucosae with accumulation of genetic/epigenetic alterations. | 19472401 |
| Bladder Neoplasm | Epigenetic Alterations | Our data suggest that instead of up-regulation of carcinogenic miRNAs, loss of regulation of these miRNA may be critical for bladder tumor development in patients. | 19475496 |
| Bladder Neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) have recently been shown to down-regulate gene expression by targeting mRNA translation and to play a critical role in tumorigenesis; how they regulate bladder tumor development, particularly in patients, is, however, poorly understood. | 19475496 |
| Hepatitis A | Epigenetic Alterations | Epigenetic factors may modulate chronic Hepatitis B viral infection by affecting virion gene transcription. | 19475606 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells. | 19490101 |
| Disease | Epigenetic Alterations | DNA methylation is an important component of epigenetic modifications, which influences the transcriptional machinery aberrant in many human diseases. | 19491193 |
| Primary malignant neoplasm | Epigenetic Alterations | Trophoblast cells and many cancer cells that harbor foreign antigens may evade immunity by epigenetic silencing of key immune response genes, including MHC class I and II and CD40. | 19493573 |
| Carcinoma of lung | Epigenetic Alterations | Transfected cell viability assays were applied to determine the effects of candidate miRNAs on lung cancer cells. | 19493678 |
| Carcinoma of lung, MIR183 wt Allele | Epigenetic Alterations | Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs. | 19493678 |
| Malignant mesothelioma | Epigenetic Alterations | MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications. | 19502386 |
| Mesothelioma | Epigenetic Alterations | Here we report, for the first time, a cross-evaluation of miRNA expression in mesothelioma (MPP-89, REN) and human mesothelial cells (HMC-telomerase reverse transcriptase). | 19502386 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) post-transcriptionally regulate the expression of target genes, and may behave as oncogenes or tumor suppressors. | 19502386 |
| Mesothelioma | Epigenetic Alterations | Microarray profiling, confirmed by real-time quantitative RT-PCR, revealed a differential expression of miRNAs between mesothelioma and mesothelial cells. | 19502386 |
| Mesothelioma | Epigenetic Alterations | This suggests that miRNAs may be key players in mesothelioma oncogenesis. | 19502386 |
| insulinoma | Epigenetic Alterations | We have previously demonstrated that epigenetic changes are an early event in a mouse model developing insulinomas. | 19502451 |
| Malignant Neoplasms | Epigenetic Alterations | Alterations of DNA methylation patterns have been suggested as biomarkers for diagnostics and therapy of cancers. | 19503099 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | To identify the DNA methylation biomarkers for the detection of the stage I non-small cell lung cancer (NSCLC). | 19506903 |
| Trauma Symptom Checklist for Children Questionnaire | Epigenetic Alterations | MicroRNA profiling was done in 10 cases of TSCC with microarray. | 19509158 |
| SERPINB3 wt Allele, Neoplasms | Epigenetic Alterations | Our study indicates that epigenetic silencing of tumor suppressor genes involved in the Ras/PI3K/AKT pathway plays an important role in OSCC radioresistance and this provides a rationale for exploring novel treatment strategies. | 19509163 |
| S100A4 protein, human | Epigenetic Alterations | To develop a timeline of aberrant DNA methylation events during malignant transformation, we analyzed genome-wide DNA methylation patterns in an isogenic human mammary epithelial cell (HMEC) culture model of transformation. | 19509227 |
| Stasis | Epigenetic Alterations | The first aberrant DNA methylation step coincides with overcoming stasis, and results in few to hundreds of changes, depending on how stasis was overcome. | 19509227 |
| Breast Carcinoma, Carcinogenesis | Epigenetic Alterations | These results show that large-scale epigenetic remodeling occurs in the earliest steps of mammary carcinogenesis, temporally links DNA methylation changes and overcoming cellular proliferation barriers, and provides a bank of potential epigenetic biomarkers that may prove useful in breast cancer risk assessment. | 19509227 |
| Carcinogenesis, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our data demonstrate that DNA methylation and histone methylation analysis of the ICR within the DMR of IGF2/H19 provides important insights into early steps of carcinogenesis and, therefore, may contribute to improving diagnosis of PCa. | 19513555 |
| Prostate Cancer Pathway, Prostatic Hyperplasia | Epigenetic Alterations | Aberrant epigenetic modifications in the CTCF binding domain of the IGF2/H19 gene in prostate cancer compared with benign prostate hyperplasia. | 19513555 |
| Malignant neoplasm of breast, Breast Carcinoma | Epigenetic Alterations | Transcriptional inactivation of breast cancer gene 1 (BRCA1) by DNA methylation is a frequent event in sporadic breast cancers. | 19522853 |
| Colorectal Cancer Pathway | Epigenetic Alterations | These results indicated that epigenetic demethylation of the CDH3 promoter in the human intestine permits its ectopic expression in colorectal cancer. | 19528483 |
| Multiple Myeloma | Epigenetic Alterations | Differential repetitive DNA methylation in multiple myeloma molecular subgroups. | 19531770 |
| Glioblastoma | Epigenetic Alterations | Epigenetic silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) by promoter methylation is associated with improved survival in glioblastomas treated with alkylating agents. | 19536096 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | We examined the correlation between miRNA expressions and the clinicopathological factors and prognosis of ESCC. | 19536617 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Expression profiling of micro-RNAs in human esophageal squamous cell carcinoma using RT-PCR. | 19536617 |
| Myeloid Leukemia, Chronic, Leukemia, Myelocytic, Acute | Epigenetic Alterations | The frequencies of DNA methylation of ID4, SFRP1, and SHP1 were higher in AML patients compared to those in CML patients. | 19543515 |
| Glioblastoma Multiforme | Epigenetic Alterations | These results suggested that epigenetic inactivation of MGMT plays an important role in the survival of glioblastoma patients and this inactivated gene involved in p53 mutation. | 19544111 |
| Neoplasms | Epigenetic Alterations | The presence of epigenetic lesions, like hypermethylation of known tumor suppressor genes such as MGMT, has been widely described in GBM, but to our knowledge, a genome-wide profile of DNA methylation changes in these lethal tumors is not yet available. | 19550145 |
| Pancreatic Neoplasm | Epigenetic Alterations | Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. | 19551852 |
| Pancreatic Neoplasm | Epigenetic Alterations | These microRNAs were chosen as they had previously been shown to be differentially expressed in pancreatic tumors compared to normal tissues. | 19551852 |
| Neoplasms, Cancer Pain | Epigenetic Alterations | Furthermore, tumors from patients demonstrating elevated expression levels of all 4 microRNAs possessed a 6.2-fold increased risk of tumor-related death compared to patients whose tumors showed a lower expression of these microRNAs. | 19551852 |
| Neoplasms | Epigenetic Alterations | Furthermore, the putative target genes for these microRNAs suggest a complex signaling network that can affect PDAC tumorigenesis and tumor progression. | 19551852 |
| Neoplasms | Epigenetic Alterations | As transcriptional regulators, altered miRNA expression may affect many cancer-related biological pathways, indicating that miRNAs can function as tumor suppressors and/or oncogenes. | 19567675 |
| Breast Carcinoma | Epigenetic Alterations | By delivering expression vectors containing either wild-type or mutant precursors of miR-196a-2 into breast cancer cells, we showed that this variant led to less efficient processing of the miRNA precursor to its mature form as well as diminished capacity to regulate target genes. | 19567675 |
| Obesity, Malignant neoplasm of esophagus | Epigenetic Alterations | These findings suggest that G1013A most likely modulates IGF-IR function, possibly by influencing gene transcription or mRNA stability, and represents a plausible mechanistic link underlying the association between obesity and esophageal malignancy. | 19582762 |
| Neoplasms | Epigenetic Alterations | These epigenetic signatures may represent an additional mechanism to promote and maintain a hypoxic-adapted cellular phenotype with a potential role in tumour development. | 19584087 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | MicroRNA classifiers for predicting prognosis of squamous cell lung cancer. | 19584273 |
| Adenocarcinoma | Epigenetic Alterations | We also identified miRNAs, including miR-155 and let-7, which had previously been shown to have prognostic value in adenocarcinoma. | 19584273 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Our data indicate that miRNAs may have greater clinical utility in predicting the prognosis of patients with squamous cell lung carcinomas than mRNA-based signatures. | 19584273 |
| Neoplasms | Epigenetic Alterations | This short lifespan would prevent the accumulation of somatic genetic mutations or epigenetic alterations necessary for tumor progression. | 19584276 |
| Primary malignant neoplasm | Epigenetic Alterations | The identification of target genes is a key step for assessing the role of aberrantly expressed microRNAs (miRNA) in human cancer and for the further development of miRNA-based gene therapy. | 19584283 |
| Hollings Cancer Center | Epigenetic Alterations | Our findings establish a basis toward the development of combined chemo- and miRNA-based therapy for HCC treatment. | 19584283 |
| Aggressive behavior, Metastasis | Epigenetic Alterations | Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence. | 19585579 |
| Malignant Neoplasms, CHOANAL ATRESIA, POSTERIOR, Prostate carcinoma | Epigenetic Alterations | Emerging evidence shows that microRNAs (miR) are involved in the pathogenesis of a variety of cancers, including prostate carcinoma (PCa). | 19585579 |
| Lymphoma, Follicular | Epigenetic Alterations | Array-based DNA methylation profiling in follicular lymphoma. | 19587707 |
| Carcinogenesis | Epigenetic Alterations | Moreover, folate insufficiency can induces carcinogenesis by decreasing DNA methylation. | 19588544 |
| Glioblastoma Multiforme | Epigenetic Alterations | In glioblastoma, low O(6)-methylguanine DNA methyltransferase (MGMT) expression is associated with epigenetic gene silencing and predicts a better response to temozolomide. | 19589911 |
| Breast Adenocarcinoma | Epigenetic Alterations | DNA methylation of K(v)1.3 potassium channel gene promoter is associated with poorly differentiated breast adenocarcinoma. | 19590190 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation is an important mechanism for gene silencing and has already been described for several genes in breast cancer. | 19590190 |
| Breast Adenocarcinoma, Neoplasms | Epigenetic Alterations | Our data suggest that DNA methylation is responsible for a decrease of K(v)1.3 gene expression in breast adenocarcinoma and is associated with poorly differentiated tumors and younger patients. | 19590190 |
| Neoplasms | Epigenetic Alterations | Recent work has shown that these miRNA expression patterns can be used to classify tumor cells, and that this classification can be more accurate than the classification achieved by using messenger RNA gene expression patterns. | 19597549 |
| Primary malignant neoplasm | Epigenetic Alterations | Detection of cancer with serum miRNAs on an oligonucleotide microarray. | 19597549 |
| Neoplasms | Epigenetic Alterations | Altered expression of specific miRNAs in several tumor types has been reported. | 19598010 |
| Fibroid Tumor, Neoplasms | Epigenetic Alterations | Recently it has been shown that repression of HMGA2 by microRNA let-7s is a critical molecular regulatory mechanism associated with tumour growth in many tumours and cell types, including leiomyomas. | 19602040 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation occurs predominantly at cytosines that precede guanines in dinucleotide CpG sites; it is one of the most important mechanisms for epigenetic DNA regulation during normal development and for aberrant DNA in cancer. | 19606065 |
| Pick Disease of the Brain, Frontotemporal Lobar Degeneration, Parkinson Disease, Lewy Bodies, Brain Diseases, Motor Neuron Disease, Dementia, "Alzheimers Disease | Epigenetic Alterations | DNA methylation was analyzed in selected regions of MAPT, APP, and PSEN1 in the frontal cortex and hippocampus of controls (n=26) and those with Alzheimer disease at Stages I to II (n=17); Alzheimer disease at Stages III to IV (n=15); Alzheimer disease at Stages V to VI (n=12); argyrophilic grain disease (n=10); frontotemporal lobar degeneration linked to tau mutations (n=6); frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions (n=4); frontotemporal lobar degeneration with motor neuron disease (n=3); Pick disease (n=3); Parkinson disease (n=8); dementia with Lewy bodies, pure form (n=5); and dementia with Lewy bodies, common form (n=15). | 19606065 |
| Degenerative disorder | Epigenetic Alterations | Because small changes in methylation of DNA promoters in vulnerable cells might have not been detected in total homogenates, however, these results should be interpreted with caution, particularly as they relate to chronic degenerative diseases in which small modifications may be sufficient to modulate disease progression. | 19606065 |
| Carcinogenesis | Epigenetic Alterations | Our results suggest that epigenetic inactivation of hMLH1 might play a role in the carcinogenesis of MSI-H gastric carcinomas. | 19621725 |
| Neoplasms | Epigenetic Alterations | Aberrant DNA methylation has the potential of being a tumor marker. | 19622308 |
| Glioblastoma Multiforme | Epigenetic Alterations | Epigenetic silencing of the MGMT gene by promoter methylation has been associated with longer survival in patients with newly diagnosed glioblastoma multiforme (GBM) who receive alkylating agents. | 19637364 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Epigenetic changes play a role and cooperate with genetic alterations in the pathogenesis of myelodysplastic syndromes (MDS). | 19638460 |
| Malignant Pleural Mesothelioma, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles. | 19638575 |
| Colorectal Cancer Pathway | Epigenetic Alterations | A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer. | 19640954 |
| Neoplasms | Epigenetic Alterations | Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia. | 19641183 |
| melanoma, Neoplasms | Epigenetic Alterations | Taken together, the present report indicates that epigenetic silencing of 14-3-3sigma might contribute to tumor progression in malignant melanoma via loss of cell cycle control, impaired cellular senescence program and support of migratory capacity. | 19642975 |
| Breast Carcinoma | Epigenetic Alterations | Clinical significance of epigenetic inactivation of hMLH1 and BRCA1 in Tunisian patients with invasive breast carcinoma. | 19644562 |
| Breast Carcinoma | Epigenetic Alterations | However, epigenetic silencing of CXCL12 has recently been reported to increase the metastatic potential of breast cancer cells and the reintroduction of the cytokine gene into MDA-MB-231 breast carcinoma cells decreases the number of metastases formed in vivo. | 19646861 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Lack of prognostic significance of serum DNA methylation of DAPK, MGMT, and GSTPI in patients with non-small cell lung cancer. | 19653236 |
| Neoplasms | Epigenetic Alterations | There were no associations between DNA methylation status and histology, tumor stage, grading or gender detectable. | 19653236 |
| Metastasis, Cholangiocarcinoma | Epigenetic Alterations | Aberrant DNA methylation of integrin alpha4: a potential novel role for metastasis of cholangiocarcinoma. | 19655168 |
| Metastasis | Epigenetic Alterations | Moreover, we found that DNA methylation of integrin alpha4 was detected in all CC tissues obtained from patients with LN metastasis (7/7). | 19655168 |
| Metastasis | Epigenetic Alterations | Taken together, these results suggest that loss of the integrin alpha4 gene is caused by aberrant DNA methylation of the 5-CpG island site of the gene, and methylation of the integrin alpha4 gene can be a useful marker of metastasis of CC. | 19655168 |
| Allergic | Epigenetic Alterations | Real-time PCR confirmed the observed increase in Th2 cytokine gene transcription in allergic patients. | 19657353 |
| Malignant tumor of colon, Metastasis | Epigenetic Alterations | MicroRNA expression profile in non-cancerous colonic tissue associated with lymph node metastasis of colon cancer. | 19659786 |
| Malignant tumor of colon, Metastasis | Epigenetic Alterations | To identify microRNA expression patterns associated with the lymph node metastasis of colon cancer. | 19659786 |
| Malignant tumor of colon, Metastasis | Epigenetic Alterations | MicroRNA were isolated from six frozen non-cancerous surrounding colonic tissues derived from stage II-III colon cancer patients with (n = 3) and without (n = 3) lymph node metastasis. | 19659786 |
| Malignant tumor of colon, Metastasis | Epigenetic Alterations | The differentially expressed microRNA could have relevance to the lymph node metastasis of colon cancer and may provide a simple profiling method to assist in identifying patients with lymph node metastasis. | 19659786 |
| Carcinogenesis | Epigenetic Alterations | The enzyme MTHFR plays an important role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair, and synthesis. | 19669769 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy. | 19669769 |
| High-Frequency Microsatellite Instability, Primary malignant neoplasm | Epigenetic Alterations | We assessed MSI-H and other genetic and epigenetic changes on survival of 990 individuals diagnosed with first primary rectal cancer. | 19669908 |
| Malignant Neoplasms, High-Frequency Microsatellite Instability, Neoplasms | Epigenetic Alterations | The genetic and epigenetic characteristics of MSI-H rectal cancers suggest that they are enriched for Lynch-associated tumors; adverse prognosis associated with MSI-H in these tumors may reflect the relatively high frequency of Lynch-associated cancers and/or the effect of radiation or chemotherapy on Lynch-associated rectal cancers or MSI tumors in general. | 19669908 |
| Hepatitis C | Epigenetic Alterations | Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. | 19671175 |
| Hepatitis C | Epigenetic Alterations | We propose an integrative strategy for identifying the miRNA-mRNA regulatory modules that are associated with HCV infection. | 19671175 |
| Disease | Epigenetic Alterations | This report demonstrates the utility of our approach to obtain new insights into post-transcriptional gene regulation at the miRNA level in complex human diseases. | 19671175 |
| Liver carcinoma, Tumor focality | Epigenetic Alterations | MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality. | 19671867 |
| Hepatocarcinogenesis | Epigenetic Alterations | MicroRNAs participate in the modulation of key molecules linked to hepatocarcinogenesis. | 19671867 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidence suggests that DNA methylation markers could serve as sensitive and specific cancer biomarkers. | 19674832 |
| Prostate carcinoma | Epigenetic Alterations | Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma. | 19676045 |
| miR-181b, human, MIR183 wt Allele | Epigenetic Alterations | Ten microRNAs (hsa-miR-16, hsa-miR-31, hsa-miR-125b, hsa-miR-145, hsa-miR-149, hsa-miR-181b, hsa-miR-184, hsa-miR-205, hsa-miR-221, hsa-miR-222) were downregulated and 5 miRNAs (hsa-miR-96, hsa-miR-182, hsa-miR-182, hsa-miR-183, hsa-375) were upregulated. | 19676045 |
| Neoplasms | Epigenetic Alterations | Expression of 5 miRNAs correlated with Gleason score or pathological tumor stage. | 19676045 |
| Prostate Cancer Pathway | Epigenetic Alterations | Thus, differential miRNAs in prostate cancer are useful diagnostic and prognostic indicators. | 19676045 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetics alterations of the 14-3-3 sigma can contribute to reducing or losing expression of 14-3-3 sigma protein, which play an important role in the development of sporadic breast carcinomas and involved in various types, grades, and lymph node metastases. | 19685192 |
| Primary malignant neoplasm | Epigenetic Alterations | Similar epigenomic and epigenetic events were frequently observed within a synchronous cancer pair, suggesting the presence of a field defect. | 19686742 |
| Malignant tumor of colon | Epigenetic Alterations | Post-transcriptional regulation mediated by RNA-binding proteins or microRNAs coordinately targets multiple genes, holding promise involved in colon cancer initiation and development. | 19686745 |
| Autoimmune Diseases | Epigenetic Alterations | Epigenetics may influence the expression of numerous genes, which might contribute to autoimmune diseases. | 19696477 |
| Malignant Neoplasms, Adenocarcinoma of pancreas | Epigenetic Alterations | We hypothesized that if aberrantly expressing microRNAs (miRNA) in pancreatic adenocarcinoma tissues are detected in blood plasma, then plasma profiling of these miRNAs might serve as a minimally invasive early detection biomarker assay for this malignancy. | 19723895 |
| Adenocarcinoma of pancreas | Epigenetic Alterations | By using a modified protocol to isolate and quantify plasma miRNAs from heparin-treated blood, we show that miRNA profiling in plasma can differentiate pancreatic adenocarcinoma patients from healthy controls. | 19723895 |
| Pancreatic carcinoma | Epigenetic Alterations | These observations, although a "proof of principle" finding at this time, show the feasibility of developing plasma miRNA profiling as a sensitive and specific blood-based biomarker assay for pancreatic cancer that has the potential of translation to the clinic with additional improvements in the future. | 19723895 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease. | 19723895 |
| Pancreatic carcinoma | Epigenetic Alterations | We have profiled four miRNAs, miR-21, miR-210, miR-155, and miR-196a, all implicated in the development of pancreatic cancer with either proven or predicted target genes involved in critical cancer-associated cellular pathways. | 19723895 |
| Gammopathy, Neoplasms | Epigenetic Alterations | DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance. | 19727727 |
| Neoplastic disease | Epigenetic Alterations | Specific epigenetic changes in normal colonic mucosa may be correlated with the occurrence and development of neoplasia in the distal colon. | 19733896 |
| Adenocarcinoma, Clear Cell, Adenocarcinoma, Oxyphilic, FLCN protein, human, Neoplasms | Epigenetic Alterations | Additional molecular genetic testing revealed somatic mutations and epigenetic events in genes typically associated with these specific histologic tumor types: oncocytoma harbored a second FLCN mutation (intron 12, IVS12+4 C>T), oncocytic papillary carcinoma harbored promoter methylation of FLCN, and a missense mutation in the MET gene (P246L), whereas clear cell carcinoma harbored inactivating VHL mutation (5-base pair deletion in exon 2) and VHL gene promoter methylation. | 19733897 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We show that the T allele at SNP rs16906252 is a key determinant in the onset of MGMT methylation in colorectal cancer, whereas the association of methylation at MGMT and CDKN2A suggests that these loci may be targets of a common mechanism of epigenetic dysregulation. | 19734844 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) have been identified as promising prognostic markers in non-small-cell lung cancer (NSCLC) since they play an important role in oncogenesis. | 19736307 |
| Adenocarcinoma of colon | Epigenetic Alterations | Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma. | 19737943 |
| Malignant tumor of colon, Carcinogenesis | Epigenetic Alterations | Inflammatory genes and microRNAs have roles in colon carcinogenesis; therefore, they may provide useful biomarkers for colon cancer. | 19737943 |
| Barrett Esophagus | Epigenetic Alterations | MicroRNA expression signatures in Barretts esophagus and esophageal adenocarcinoma. | 19737949 |
| Malignant Neoplasms, Adenocarcinoma Of Esophagus | Epigenetic Alterations | Although microRNA (miRNA) expression signatures have been associated with the etiology and prognosis of several types of cancers, their roles in the development of esophageal adenocarcinoma have not been extensively evaluated. | 19737949 |
| Barretts esophagus with low grade dysplasia | Epigenetic Alterations | Finally, we identified several miRNAs that were involved in the progressions from low grade-dysplasia Barretts esophagus to esophageal adenocarcinoma. | 19737949 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | We showed that miRNAs were involved in the development and progression of esophageal adenocarcinoma. | 19737949 |
| Esophageal carcinoma | Epigenetic Alterations | The identified significant miRNAs that may become potential targets for early detection, chemoprevention, and treatment of esophageal cancer. | 19737949 |
| Colorectal Carcinoma | Epigenetic Alterations | Concordant DNA methylation in synchronous colorectal carcinomas. | 19737982 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Epigenetic changes have been proposed as mediators of the field defect in colorectal carcinogenesis, which has implications for risk assessment and cancer prevention. | 19737982 |
| Primary malignant neoplasm | Epigenetic Alterations | Genomic variation within miRNA target sites may therefore be important sources for genetic differences in cancer risk. | 19738052 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs regulate diverse cellular processes and play an integral role in cancer pathogenesis. | 19738052 |
| Oral Cavity Carcinoma, mucosa-associated lymphoid tissue | Epigenetic Alterations | Epigenetic loss of mucosa-associated lymphoid tissue 1 expression in patients with oral carcinomas. | 19738055 |
| Prostatic Neoplasms | Epigenetic Alterations | Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. | 19738602 |
| Prostate Cancer Pathway | Epigenetic Alterations | Here, we show that microRNA (miR)-16, which is expressed at lower levels in prostate cancer cells, affects the proliferation of human prostate cancer cell lines both in vitro and in vivo. | 19738602 |
| Prostate Cancer Pathway, Neoplasm Metastasis | Epigenetic Alterations | Thus, this study indicates the therapeutic potential of miRNA in an animal model of cancer metastasis with systemic miRNA injection and suggest that systemic delivery of miR-16 could be used to treat patients with advanced prostate cancer. | 19738602 |
| Metastasis | Epigenetic Alterations | Recent reports have linked the expression of specific microRNAs (miRNAs) with tumorigenesis and metastasis. | 19738602 |
| Obesity, Pulmonary Hypertension, Thyroid Diseases | Epigenetic Alterations | The coexistent high prevalence in our cohort of exogenous estrogen exposure, thyroid disease and obesity suggests that an interaction of multiple endocrine factors might contribute to the pathogenesis of pulmonary hypertension and may represent epigenetic modifiers in genetically-susceptible individuals. | 19748850 |
| Human papilloma virus infection | Epigenetic Alterations | Folate status and aberrant DNA methylation are associated with HPV infection and cervical pathogenesis. | 19755648 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant DNA methylation is a recognized feature of human cancers, and folate is directly involved in DNA methylation via one-carbon metabolism. | 19755648 |
| cervical cancer | Epigenetic Alterations | A cross-sectional study was conducted to test the hypothesis that folate status and aberrant DNA methylation show a progressive change across stages of cervical pathology from normal cells to cervical cancer. | 19755648 |
| Malignant - descriptor | Epigenetic Alterations | It appeared that CpG was unique in that it raised the membrane expression of CD20 on malignant B cells, owing to a PU.1 independent increase in its gene transcription. | 19758221 |
| Neoplasms | Epigenetic Alterations | These data indicate that tumour progression and angiogenesis are not directly influenced by VHL alterations and that additional genetic/epigenetic events should be considered to explain the diverse angiogenic and proliferative behaviour during tumour progression. | 19759417 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Characterization of B- and T-lineage acute lymphoblastic leukemia by integrated analysis of MicroRNA and mRNA expression profiles. | 19760605 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Furthermore, we identified miR-148, miR-151, and miR-424 as discriminative of T-lineage versus B-lineage ALL; ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions. | 19760605 |
| Liver carcinoma | Epigenetic Alterations | Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma. | 19760608 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Investigating aberrant DNA methylation in the cancer genome may identify genes that play an important role in tumor progression. | 19760608 |
| Neoplasms | Epigenetic Alterations | Moreover, KLK10 and OXGR1 mRNA levels were inversely correlated (r = -0.435 and -0.497, P < 0.05) with DNA methylation as examined in paired adjacent normal and tumor samples. | 19760608 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Different histological types of non-small cell lung cancer have distinct folate and DNA methylation levels. | 19764999 |
| Carcinoma of lung | Epigenetic Alterations | Aberrant DNA methylation is a commonly observed epigenetic change in lung cancer. | 19764999 |
| Primary malignant neoplasm | Epigenetic Alterations | Folate has been suggested to play a role in the homeostasis of DNA methylation and has also been implicated in cancer chemotherapy. | 19764999 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our results suggest that folate metabolism plays a role in aberrant DNA methylation in NSCLC. | 19764999 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31. | 19768731 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Twelve GISTs were evaluated for differential miRNA expression signatures by use of microarrays representing 734 human miRNAs. | 19768731 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | miRNA profiling may prove to be a key determinant of the biology and clinical features of GISTs. | 19768731 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Differential expression was further analysed and confirmed for four miRNAs (miR-132, miR-221, miR-222, and miR-504) by qRT-PCR in 49 additional GISTs. | 19768731 |
| Gastrointestinal Stromal Tumors, Neoplasms | Epigenetic Alterations | This was confirmed for two selected miRNAs (miR-134 and miR-370) from the 14q32.31 cluster by qRT-PCR in 49 additional GISTs, and the expression of these two miRNAs was significantly lower in GISTs with 14q loss, and also in GISTs with tumour progress. | 19768731 |
| Colorectal Cancer Pathway | Epigenetic Alterations | To identify epigenetic molecular makers in plasma for the early detection of colorectal cancer. | 19773381 |
| Carcinoma, Transitional Cell, Transitional epithelial cell of urinary bladder | Epigenetic Alterations | Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage. | 19775289 |
| Carcinogenesis | Epigenetic Alterations | The combination of DNA methylation status on 83 BAC clones selected by Wilcoxon test was able to completely discriminate N from C, and diagnose N as having a high risk of carcinogenesis, with 100% sensitivity and specificity. | 19775289 |
| Ulcerative Colitis | Epigenetic Alterations | The combination of DNA methylation status for 11 BAC clones selected by Wilcoxon test was able to completely discriminate patients with UCs of the renal pelvis or ureter who suffered from intravesical metachronous UC development from patients who did not. | 19775289 |
| Carcinogenesis, Ulcerative Colitis, Carcinogens | Epigenetic Alterations | Genome-wide alterations of DNA methylation may participate in urothelial carcinogenesis from the precancerous stage to UC, and DNA methylation profiling may provide optimal indicators for carcinogenetic risk estimation and prognostication. | 19775289 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Increased microsatellite instability and epigenetic inactivation of the hMLH1 gene in head and neck squamous cell carcinoma. | 19786217 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | The study is designed to elucidate the relationship between epigenetic silencing of the hMLH1 (human MutL homologue 1) gene and microsatellite instability (MSI) and the prognostic values of hMLH1 promoter methylation and MSI in head and neck squamous cell carcinoma (HNSCC). | 19786217 |
| Malignant neoplasm of larynx, Neoplasms | Epigenetic Alterations | Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer. | 19787239 |
| Malignant Neoplasms, Malignant neoplasm of lung | Epigenetic Alterations | Lethal-7a (let-7a) is a founding member of miRNA family and recently it was found to be associated with several cancers, such as lung and colon cancers. | 19787239 |
| Laryngeal Squamous Cell Carcinoma, Malignant neoplasm of larynx | Epigenetic Alterations | In the present study, we found that let-7a miRNA expression was significantly downregulated both in human laryngeal squamous cancer tissues and in Hep-2 cells, a laryngeal cancer cell line, as compared with adjacent normal tissues and BEAS-2B cells, respectively. | 19787239 |
| Liver carcinoma, S100A4 protein, human, Hollings Cancer Center | Epigenetic Alterations | There is significant regional variation in the etiologic agents responsible for hepatocellular carcinoma (HCC), which influences the genetic and epigenetic mechanisms of malignant transformation. | 19787262 |
| Pancreatic carcinoma | Epigenetic Alterations | We have previously identified transcriptional changes in highly nerve invasive pancreatic cancer cells. | 19787265 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer. | 19787768 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The primary objective of this study is to identify prognostic site-specific epigenetic changes in surgically treated Stage I and II nonsmall cell lung cancer (NSCLC) patients by quantifying methylation levels at multiple CpG sites within each gene promoter. | 19795445 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | MicroRNA expression profile of gastrointestinal stromal tumors is distinguished by 14q loss and anatomic site. | 19795448 |
| Gastrointestinal Stromal Tumors, Neoplasms | Epigenetic Alterations | Although unique microRNA expression profiles have been reported in several tumors, little is known about microRNA expression profiles in GISTs. | 19795448 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | To evaluate the relationship between microRNA expression and clinicopathologic findings of GISTs, we analyzed the microRNA expression profiles of GISTs. | 19795448 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Using unsupervised hierarchical clustering analysis, we found four distinct microRNA expression patterns in our 20 GISTs. | 19795448 |
| Gastrointestinal Stromal Tumors, Neoplasms | Epigenetic Alterations | The microRNA expression patterns of GISTs are closely related to the status of 14q loss, anatomic site, and tumor risk. | 19795448 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | These findings suggest that microRNA expression patterns can differentiate several subsets of GISTs. | 19795448 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | We found 73 microRNAs that were significantly down-regulated in the GISTs with 14q loss; 38 of these microRNAs are encoded on 14q. | 19795448 |
| Gastrointestinal Stromal Tumors, Intestines, Small | Epigenetic Alterations | We also found many microRNAs that were down-regulated in small bowel and high-risk group GISTs. | 19795448 |
| Intestines, Small, Neoplasms | Epigenetic Alterations | Most of the microRNAs down-regulated in the high-risk group and small bowel GISTs are known to be involved in tumor progression, specifically by stimulating mitogen-activated protein kinase (MAPK) and the cell cycle. | 19795448 |
| Nephrotic Syndrome | Epigenetic Alterations | However, to date, our knowledge about the alterations in histone modification in minimal change nephrotic syndrome (MCNS) is unknown. | 19797895 |
| Neoplasms | Epigenetic Alterations | To determine the hypermethylation status of the promoter regions of tumour suppressor genes in breast tissues from healthy women and identify the determinants of these epigenetic changes. | 19799643 |
| Carcinogenesis | Epigenetic Alterations | Recently, researchers have found that microRNAs play several important roles in carcinogenesis. | 19802518 |
| Cutaneous Precancerous Condition, Gastritis | Epigenetic Alterations | Global genome hypomethylation has a fundamental role in early stages of tumorigenesis but little is known about this epigenetic event in gastric precancerous lesions such as gastritis. | 19806785 |
| Stomach Carcinoma, Carcinogenesis | Epigenetic Alterations | This reduction probably continues in the next steps toward gastric cancer and may induce other epigenetic and/or genetic changes (such as MSI) that promote carcinogenesis. | 19806785 |
| Neoplastic disease, Primary malignant neoplasm | Epigenetic Alterations | Our findings support the idea that neoplasia may lead to a deregulation of miRNA expression in blood cells of cancer patients compared to blood cells of healthy individuals. | 19807914 |
| Malignant Neoplasms | Epigenetic Alterations | Furthermore, we provide evidence that miRNA patterns can be used to detect human cancers from blood cells. | 19807914 |
| Primary malignant neoplasm | Epigenetic Alterations | Deregulated miRNAs are found in cancer cells and recently in blood cells of cancer patients. | 19807914 |
| Neoplasms | Epigenetic Alterations | Due to their inherent stability miRNAs may offer themselves for blood based tumor diagnosis. | 19807914 |
| Primary malignant neoplasm | Epigenetic Alterations | Here we addressed the question whether there is a sufficient number of miRNAs deregulated in blood cells of cancer patients to be able to distinguish between cancer patients and controls. | 19807914 |
| Carcinoma of lung | Epigenetic Alterations | Using t-test, we detected 27 miRNAs significantly deregulated in blood cells of lung cancer patients as compared to the controls. | 19807914 |
| Glioblastoma Multiforme | Epigenetic Alterations | Methylation of CpG islands in cancer-related genes may serve as an epigenetic biomarker for glioblastoma diagnosis and prognosis. | 19809523 |
| Myelofibrosis, Thrombocytosis | Epigenetic Alterations | MicroRNA expression profiling of megakaryocytes in primary myelofibrosis and essential thrombocythemia. | 19811223 |
| PRB1 gene, Thrombocytosis, Primary Myelofibrosis | Epigenetic Alterations | In primary myelofibrosis (PMF) and essential thrombocythemia (ET) the megakaryocytic lineage characteristically shows aberrant proliferation and maturation in which the regulatory microRNA (miR) system might be involved. | 19811223 |
| Cluster | Epigenetic Alterations | Cluster analysis revealed a tendency of disease-specific megakaryocytic microRNA expression profiles indicating that a complex shift of microRNA expression appears to be the underlying defect. | 19811223 |
| PRB1 gene | Epigenetic Alterations | In conclusion, this is the first microRNA profiling of in situ-derived PMF, ET and normal megakaryocytes. | 19811223 |
| PRB1 gene | Epigenetic Alterations | Laser-microdissected PMF and ET megakaryocytes were analysed with real-time polymerase chain reaction (PCR) low density arrays comprising 365 microRNAs. | 19811223 |
| Malignant neoplasm of liver | Epigenetic Alterations | MicroRNA expression, survival, and response to interferon in liver cancer. | 19812400 |
| Liver carcinoma | Epigenetic Alterations | The expression patterns of microRNAs in liver tissue differ between men and women with hepatocellular carcinoma. | 19812400 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | Concordance of DNA methylation pattern in plasma and tumor DNA of Egyptian hepatocellular carcinoma patients. | 19818350 |
| Communicable Diseases, Stomach Carcinoma | Epigenetic Alterations | Helicobacter pylori (HP) infection potently induces aberrant DNA methylation in gastric mucosae, and its accumulation is associated with gastric cancer risk. | 19821005 |
| Septicemia | Epigenetic Alterations | MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. | 19823581 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation is considered a major mechanism for silencing tumor suppressor genes in gastric cancer. | 19824040 |
| Stomach Carcinoma | Epigenetic Alterations | Additional experiments showed that the promoter region of GRIK2 was hypermethylated in 3 of the 4 tested gastric cancer cell lines, and its expression was restored by treatment of cells with the DNA methylation inhibitor, 5-aza-dC. | 19824040 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | We used CpG microarray and differential methylation hybridization strategies to identify potential tumor suppressor genes and recovered glutamate receptor, ionotropic, kainate 2 (GRIK2) as a novel epigenetic target in gastric cancer. | 19824040 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic silencing of E-cadherin via aberrant methylation has been investigated in various human tumors, whereas evidence for elucidating mechanism underlying reduction of E-cadherin mRNA remains unclear in non-small cell lung cancer (NSCLC). | 19842844 |
| Carcinogenesis, Colorectal Cancer Pathway | Epigenetic Alterations | Aberrant DNA methylation affects carcinogenesis of colorectal cancer. | 19843671 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. | 19843671 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Distinct microRNA alterations characterize high- and low-grade bladder cancer. | 19843843 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent evidence implicates a regulatory role for microRNA in cancer. | 19843843 |
| Carcinogenesis | Epigenetic Alterations | We hypothesized that altered microRNA expression contributes to UCC carcinogenesis. | 19843843 |
| Neoplasms | Epigenetic Alterations | In UCC, microRNA alterations occur in a tumor phenotype-specific manner and can predict disease progression. | 19843843 |
| Squamous cell carcinoma, SERPINB3 wt Allele | Epigenetic Alterations | However, to date the somatic epigenetic events that occur in cutaneous squamous cell carcinoma (SCC) tumorigenesis have not been well defined. | 19845668 |
| FOXE1 gene | Epigenetic Alterations | To examine epigenetic abnormalities of FOXE1, a gene located on chromosome 9q22, a region frequently lost in SCC. | 19845668 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetic gene silencing due to promoter methylation is observed in human cancers like acute myeloid leukemia (AML). | 19853913 |
| Neoplasms | Epigenetic Alterations | We observed mild to moderate DNA methylation levels in most tumors for ESR1 promoters A and B and PGR promoter B, and a few tumors showed mild methylation in PGR promoter A. | 19861523 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetic regulation of the non-canonical Wnt pathway in acute myeloid leukemia. | 19874313 |
| Neoplasms, Leukemia, Myelocytic, Acute | Epigenetic Alterations | We demonstrate that WNT5A, a putative tumor suppressor gene in AML, is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression and confers poor prognosis in patients with AML. | 19874313 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA) opens up a new field for molecular diagnosis of cancer. | 19876917 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. | 19876917 |
| Primary malignant neoplasm | Epigenetic Alterations | However, the role of circulating miRNAs in plasma/serum in cancer diagnosis is not clear. | 19876917 |
| Adenoma | Epigenetic Alterations | More importantly, these 2 miRNAs also could discriminate advanced adenomas from controls and yielded an AUC of 0.769 for miR-29a and 0.749 for miR-92a. | 19876917 |
| Neoplasms | Epigenetic Alterations | Detection of these epigenetic changes in circulating DNA may not only enhance insight into the biological behavior of the primary tumor of an individual but may also provide valuable information regarding prognosis that can be readily monitored throughout the disease course. | 19879256 |
| Schizophrenia | Epigenetic Alterations | Schizophrenia is a multifactorial disorder characterized by the contribution of multiple susceptibility genes that may act in conjunction with epigenetic processes and environmental factors. | 19881467 |
| Carcinogenesis | Epigenetic Alterations | Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis. | 19881551 |
| Carcinogenesis | Epigenetic Alterations | Such an important epigenetic link between glycolysis and carcinogenesis partly explains the Warburg effect. | 19881551 |
| Thyroid Diseases | Epigenetic Alterations | An interplay of genetic, epigenetic, and environmental factors contributes to thyroid disease. | 19882500 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Hematopoiesis-related microRNA expression in myelodysplastic syndromes. | 19883312 |
| SF3B1 wt Allele | Epigenetic Alterations | We assessed 25 mature miRNAs in total RNA from bone marrow (BM) and peripheral blood (PB) of 25 newly diagnosed patients with MDS and 12 controls. | 19883312 |
| SF3B1 wt Allele | Epigenetic Alterations | Twelve miRNAs in BM and six in PB were differentially expressed between patients with MDS and controls. | 19883312 |
| SF3B1 wt Allele, Leukemia, Myelocytic, Acute | Epigenetic Alterations | This study adds further evidence to the role of miRNAs in the pathogenesis of MDS and their transformation into AML. | 19883312 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | Squamous cell carcinomas of head and neck (HNSCC) are a result of multiple genetic and epigenetic alterations. | 19885608 |
| Head and Neck Carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic inactivation of tumor suppressor genes is an important event in head and neck carcinogenesis. | 19885608 |
| Head and Neck Carcinoma | Epigenetic Alterations | In summary, frequent hyper-methylation of tumor-related genes in HNSCC was detected and this epigenetic silencing event may have an essential role in head and neck carcinogenesis. | 19885608 |
| Colorectal Carcinoma | Epigenetic Alterations | Colorectal cancers (CRCs) may be classified according to underlying genetic and epigenetic changes including microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). | 19885699 |
| Malignant Neoplasms, Malignant Pleural Mesothelioma | Epigenetic Alterations | Malignant pleural mesothelioma (MPM) is a fatal thoracic malignancy, the epigenetics of which are poorly defined. | 19887624 |
| Malignant Pleural Mesothelioma, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma. | 19887624 |
| Neoplasms | Epigenetic Alterations | Our findings show a characteristic epigenetic profile of MPM and uncover multiple distinct epigenetic abnormalities that lead to the silencing of tumor suppressor genes in MPM and could serve as diagnostic or prognostic targets. | 19887624 |
| Ischemic stroke | Epigenetic Alterations | We therefore carried out microRNA (miRNA) profiling from peripheral blood to detect and identify characteristic patterns in ischaemic stroke. | 19888324 |
| Cerebrovascular accident | Epigenetic Alterations | Expression profile of MicroRNAs in young stroke patients. | 19888324 |
| Ischemic stroke | Epigenetic Alterations | We demonstrate that the peripheral blood miRNAs and their profiles can be developed as biomarkers in diagnosis and prognosis of cerebral ischaemic stroke. | 19888324 |
| Cerebrovascular accident | Epigenetic Alterations | The dysregulated miRNAs have been detectable even after several months from the onset of stroke in what is usually regarded as neurologically stable patients. | 19888324 |
| Neoplasms | Epigenetic Alterations | In order to estimate the overall susceptibility of MSs to MSI in MSI-H tumors, the observed MSI frequency of each MS was correlated with its length, interspecies sequence conservation level, and distance from some genetic elements (i.e., stop codon, polyA signal, and microRNA binding sites). | 19888451 |
| Seizures | Epigenetic Alterations | The predicted loss of a microRNA-accessible structure in mutant RB1CC1 RNA fits the hypothesis that 3UTR MSI involves in aberrant RB1CC1 posttranscriptional upregulation. | 19888451 |
| Endometrial Serous Adenocarcinoma | Epigenetic Alterations | A total of 120 miRNAs were differentially expressed in endometrial serous adenocarcinoma compared to normal endometria. | 19891660 |
| Endometrial Serous Adenocarcinoma | Epigenetic Alterations | These findings suggest that the dysregulation of miRNAs is associated with the poor prognosis in endometrial serous adenocarcinoma patients. | 19891660 |
| DNA Mismatch Repair Protein MSH2, human, mismatch repair protein 1, human | Epigenetic Alterations | The aberrant DNA methylation patterns of four mismatch repair genes, hMLH1, hMSH2, hMSH3, and MGMT, were compared by bisulfite modification and methylation-specific PCR (MSP). | 19894224 |
| Stomach Carcinoma | Epigenetic Alterations | Aberrant methylation of DNA mismatch repair genes in elderly patients with sporadic gastric carcinoma: A comparison with younger patients. | 19894224 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Breast cancer is one of the most common cancer affecting women and the recent research is focused on identifying new genetic and epigenetic prognostic and predictive factors. | 19895170 |
| Acute myocardial infarction | Epigenetic Alterations | Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction. | 19896465 |
| Malignant Neoplasms | Epigenetic Alterations | Circulating miRNAs have been proposed as sensitive and informative biomarkers for multiple cancers diagnosis. | 19896465 |
| Neoplasms | Epigenetic Alterations | Finally, the significance of DNA methylation in regulating gene promoters was shown by reinducing 4 methylated tumor suppressor genes (eg, VHL and ABI3) in IGHV unmutated samples using the methyl-inhibitor 5-aza-2-deoxycytidine. | 19897574 |
| Primary malignant neoplasm, Chronic Lymphocytic Leukemia | Epigenetic Alterations | Global hypomethylation and regional hypermethylation are well-known epigenetic features of cancer; however, in chronic lymphocytic leukemia (CLL), studies on genome-wide epigenetic modifications are limited. | 19897574 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Taken together, our data for the first time reveal differences in global methylation profiles between prognostic subsets of CLL, which may unfold epigenetic silencing mechanisms involved in CLL pathogenesis. | 19897574 |
| Endometrial Carcinoma, Hyperplasia, Federation of Gynecology and Obstetrics, Carcinoma | Epigenetic Alterations | DNA methylation of the APC gene increased from atypical hyperplasia (23.5%) to endometrial carcinoma, reaching its highest level of 77.4% in early stage cancer (FIGO I and II) and decreasing stepwise to 24.2% in advanced stage carcinomas (FIGO III and IV). | 19900189 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | MicroRNA expression in head and neck cancer associates with alcohol consumption and survival. | 19901002 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Together, these data suggest that alterations in miRNA expression are related to exposures causal in head and neck cancer and may be useful biomarkers of patient outcome. | 19901002 |
| IGA Glomerulonephritis | Epigenetic Alterations | These miRNA species may be important in the pathogenesis and progression of IgA nephropathy. | 19901913 |
| IGA Glomerulonephritis | Epigenetic Alterations | Intrarenal expression of microRNAs in patients with IgA nephropathy. | 19901913 |
| Malignant neoplasm of kidney, Glomerulosclerosis (disorder) | Epigenetic Alterations | The intrarenal expression of miRNAs was quantified and compared with that of 15 patients with noninflammatory glomerulosclerosis (GS group) and 20 patients with nephrectomy for kidney cancer as controls (CTL group). | 19901913 |
| Renal sclerosis with hypertension | Epigenetic Alterations | The results suggested that these miRNA species may play important roles in the pathogenesis of hypertensive nephrosclerosis. | 19910931 |
| Renal sclerosis with hypertension | Epigenetic Alterations | Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis. | 19910931 |
| Metastasis, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Tumor invasiveness and metastasis in cancer progression is manifested by epigenetic abnormality. | 19914229 |
| Liver carcinoma | Epigenetic Alterations | An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3 untranslated region confers risk for hepatocellular carcinoma. | 19917630 |
| Primary malignant neoplasm | Epigenetic Alterations | Genetic polymorphisms in 3 untranslated regions (3 UTRs) targeted by miRNAs alter the strength of miRNA binding, with consequences on regulation of target genes thereby affecting the individuals cancer risk. | 19917630 |
| Primary malignant neoplasm | Epigenetic Alterations | We have previously predicted polymorphisms falling in miRNA-binding regions of cancer genes. | 19917630 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Differential expression of miRNA patterns in renal cell carcinoma and nontumorous tissues. | 19921256 |
| Renal Cell Carcinoma | Epigenetic Alterations | The report supports that many miRNA expressions were altered in renal carcinoma, whose expression profiling may provide a useful clue for the pathophysiology research. | 19921256 |
| Breast Carcinoma | Epigenetic Alterations | We analyzed four SNPs, one located in the pre-miRNA and the other three located in miRNA flanking regions, for a putative association with breast cancer risk. | 19921425 |
| Breast Carcinoma | Epigenetic Alterations | Our results suggest that promoter methylation could be promising epigenetic markers to be considered for breast cancer survival. | 19921426 |
| Right arm | Epigenetic Alterations | miRNA expression profile analysis highlighted that miR-223 is the only miRNA that is strikingly deregulated in peripheral T-lymphocytes from RA patients compared with healthy donors. | 19931339 |
| Right arm | Epigenetic Alterations | In summary, our data provide a first characterization of the miRNA expression profiles of peripheral T-lymphocytes of RA patients, identifying miR-223 as overexpressed in CD4(+) naive T-lymphocytes from these individuals. | 19931339 |
| Carcinogenesis | Epigenetic Alterations | Alterations in the RAS and RAF pathway relate to epigenetic and epigenomic aberrations, and are important in colorectal carcinogenesis. | 19934290 |
| Prostate Cancer Pathway, Retinitis Pigmentosa | Epigenetic Alterations | In combination with the Gleason score and pre-operation PSA level, the acetylation and methylation of histones H3 and H4 can predict the biochemical recurrence of the prostate cancer following RP. | 19935671 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer. | 19936946 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen. | 19938198 |
| Carcinogenesis | Epigenetic Alterations | The results suggest that JCV T-Ag is involved in gastric carcinogenesis through multiple mechanisms of genetic and epigenetic alterations. | 19938198 |
| Weight decreased | Epigenetic Alterations | These data show that both DNA methylation and gene expression are responsive to caloric restriction and provide new insights about the molecular pathways involved in body weight loss as well as methylation regulation during adulthood. | 19939982 |
| Glioblastoma Multiforme | Epigenetic Alterations | Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation. | 19941032 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Our data suggests that down-regulation of miRNA-128 may contribute to glioma and GBM, in part, by coordinately up-regulating ARP5 (ANGPTL6), Bmi-1 and E2F-3a, resulting in the proliferation of undifferentiated GBM cells. | 19941032 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | ZAP-70 intron1 DNA methylation status: determination by pyrosequencing in B chronic lymphocytic leukemia. | 19944462 |
| Stomach Carcinoma | Epigenetic Alterations | Survival prediction of gastric cancer by a seven-microRNA signature. | 19951901 |
| Primary malignant neoplasm | Epigenetic Alterations | Several microarray studies have reported microRNA (miRNA) expression signatures that classify cancer patients into different prognostic groups. | 19951901 |
| Stomach Carcinoma | Epigenetic Alterations | In this study, we developed a seven-miRNA signature that is closely associated with survival of patients with gastric cancer. | 19951901 |
| Stomach Carcinoma | Epigenetic Alterations | MiRNA expression profile was analysed by real-time RT-PCR in 100 gastric cancer patients, which were randomly assigned to either the training set or the testing set. | 19951901 |
| Stomach Carcinoma | Epigenetic Alterations | We have identified a seven-miRNA signature (miR-10b, miR-21, miR-223, miR-338, let-7a, miR-30a-5p, miR-126) for overall survival (p=0.0009) and relapse-free survival (p=0.0005) of gastric cancer patients. | 19951901 |
| Stomach Carcinoma | Epigenetic Alterations | Our seven-miRNA signature is closely associated with relapse-free and overall survival among patients with gastric cancer. | 19951901 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Early life exposure to famine and colorectal cancer risk: a role for epigenetic mechanisms. | 19956740 |
| Clinical Coordinator | Epigenetic Alterations | This is the first study indicating that exposure to a severe, transient environmental condition during adolescence and young adulthood may result in persistent epigenetic changes that later influence CRC development. | 19956740 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic silencing of RELN in gastric cancer. | 19956836 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Epigenetic alteration of tumor-related genes through changes of DNA methylation is a hallmark for carcinogenesis and aberrant DNA methylation modulates the activity of tumor suppressor genes, imprinted genes and repetitive elements. | 19956846 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | High expression of microRNA-15b predicts a low risk of tumor recurrence following curative resection of hepatocellular carcinoma. | 19956871 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNA) have recently been implicated in carcinogenesis and tumor progression. | 19956871 |
| Hollings Cancer Center | Epigenetic Alterations | We attempted to identify the miRNAs associated with HCC recurrence. | 19956871 |
| Hollings Cancer Center | Epigenetic Alterations | Out of 449 miRNAs assayed, we identified seven miRNAs associated with HCC recurrence. | 19956871 |
| Anaplastic large B-cell lymphoma, B-Cell Lymphomas, Neoplasms | Epigenetic Alterations | These results indicate that global histone modification profiles specific to non-neoplastic germinal center B lymphocytes and mantle zone B lymphocytes are well conserved in corresponding neoplastic lymphoma cells, and suggest that they will be indicative of tumor cell type at least in B cell lymphoma. | 19960376 |
| Breast Cancer Cell | Epigenetic Alterations | MicroRNA (miRNA) deregulation is a hallmark of human cancer. | 19960504 |
| DICER1 protein, human | Epigenetic Alterations | Dicer is a key enzyme in the miRNA processing pathway that is essential for the production of mature miRNAs from their precursors. | 19960504 |
| DICER1 protein, human | Epigenetic Alterations | Our data suggest a common mechanism for miRNAs changes by alterations in the basic machinery controlling miRNA biogenesis, of which Dicer is a central enzyme. | 19960504 |
| Ovarian Carcinoma, Neoplasms | Epigenetic Alterations | These alterations of miRNA processing are of prognostic value and may play a role in the molecular pathogenesis of ovarian carcinoma and, possibly, other tumours. | 19960504 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer. | 19966864 |
| Aggressive behavior | Epigenetic Alterations | Gene networks and microRNAs implicated in aggressive prostate cancer. | 19996289 |
| Prostate Cancer Pathway | Epigenetic Alterations | Further characterization of cell cycle-related genes (particularly, the hub genes) and miRNAs that regulate these hub genes could facilitate identification of candidate genes responsible for the aggressive phenotype and lead to a better understanding of prostate cancer etiology and progression. | 19996289 |
| Carcinogenesis | Epigenetic Alterations | DNA methylation is a common event in gastric carcinogenesis. | 20001710 |
| MYELODYSPLASTIC SYNDROME, Neoplasms | Epigenetic Alterations | Epigenetic inactivation of tumour suppressor gene KLF11 in myelodysplastic syndromes*. | 20002157 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | The identification of aberrantly hypermethylated genes may lead to the development of new diagnostic markers and the identification of novel targets of epigenetic therapy in myelodysplastic syndromes (MDS). | 20002157 |
| SF3B1 wt Allele | Epigenetic Alterations | In conclusion, epigenetic inactivation and subsequent transcriptional repression of the KLF11 gene is quite frequent in MDS. | 20002157 |
| Adult T-Cell Lymphoma/Leukemia, TCL4 gene | Epigenetic Alterations | However, little is known about the association of epigenetic abnormalities with multistep tumorigenic events in adult T cell leukemia/lymphoma (ATLL). | 20019193 |
| Adult T-Cell Lymphoma/Leukemia | Epigenetic Alterations | To determine whether epigenetic abnormalities induce the progression of ATLL, we analyzed the methylation profiles of the SHP1, p15, p16, p73, HCAD, DAPK, hMLH-1, and MGMT genes by methylation specific PCR assay in 65 cases with ATLL patients. | 20019193 |
| Neoplasms | Epigenetic Alterations | Analyses of microRNA expression profiles have shown that many microRNAs are expressed aberrantly and correlate with tumorigenesis, progression, and prognosis of various haematological and solid tumours. | 20022810 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA expression patterns were compared between non-tumour mucosa and cancer samples, graded by diffuse and intestinal histological types and by progression-related factors (eg, depth of invasion, metastasis, and stage). | 20022810 |
| Stomach Carcinoma, Intestinal Cancer | Epigenetic Alterations | The two histological subtypes of gastric cancer showed different microRNA signatures: eight microRNAs were upregulated in diffuse-type and four in intestinal-type cancer. | 20022810 |
| Malignant neoplasm of stomach | Epigenetic Alterations | MicroRNAs are expressed differentially in gastric cancers, and histological subtypes are characterised by specific microRNA signatures. | 20022810 |
| Stomach Carcinoma | Epigenetic Alterations | Unique microRNAs are associated with progression and prognosis of gastric cancer. | 20022810 |
| Childhood Leukemia, Primary malignant neoplasm, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study. | 20026798 |
| Cytogenetically normal acute myeloid leukemia, Leukemia, Myelocytic, Acute | Epigenetic Alterations | To analyze the prognostic significance of NPM1 mutations, and the associated gene- and microRNA-expression signatures in older patients with de novo, cytogenetically normal acute myeloid leukemia (CN-AML) treated with intensive chemotherapy. | 20026798 |
| Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | Gene- and microRNA-expression profiles associated with NPM1 mutations were similar across older patient age groups and similar to those in younger (< 60 years) patients with CN-AML. | 20026798 |
| Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | The gene- and microRNA-expression profiles suggest that NPM1 mutations constitute a marker defining a biologically homogeneous entity in CN-AML that might be treated with specific and/or targeted therapies across age groups. | 20026798 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Altered microRNA (miRNA) expression has been associated with both cancer progression and metastasis. | 20028561 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Evaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after surgical resection. | 20028859 |
| Non-Small Cell Lung Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | We surveyed expression profiles of microRNA (miRNA) in stage I NSCLC to identify patterns that might predict recurrence after surgical resection of this common deadly cancer. | 20028859 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our findings reinforce efforts to profile miRNA expression patterns for better prognostication of stage I NSCLC. | 20028859 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction. | 20029200 |
| Myocardium, Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | In recent studies, three miRNAs have been described as muscle or cardiac specific: miR-1, miR-133, and miR-208, being involved in heart development and disease; but there are limited data on their role in human myocardial infarction (MI). | 20029200 |
| Papillary thyroid carcinoma, Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear Features | Epigenetic Alterations | Differential miRNA expression profiles in variants of papillary thyroid carcinoma and encapsulated follicular thyroid tumours. | 20029416 |
| Methylnitronitrosoguanidine | Epigenetic Alterations | The mean values of the expression pattern of all miRNAS in PTCs show a statistically significant difference from those in MNG and FA with fold changes up to 90 for miRNA 146b, P<0.001. | 20029416 |
| Methylnitronitrosoguanidine | Epigenetic Alterations | The PTC-FVs differ significantly from FA in all five miRNAS, from MNG in three and from WDT-UMP in one miRNA with fold changes between 1.7 and 21.2, but failed to be of diagnostic value regarding individual cases with substantial overlaps. | 20029416 |
| Acute Coronary Syndrome | Epigenetic Alterations | T cell DNA methylation levels decline with age, activating genes such as KIR and TNFSF7 (CD70), implicated in lupus-like autoimmunity and acute coronary syndromes. | 20035856 |
| S-Adenosylhomocysteine | Epigenetic Alterations | Maintenance of DNA methylation depends on DNA methyltransferase 1 (Dnmt1) and intracellular S-adenosylmethionine (SAM) levels, and is inhibited by S-adenosylhomocysteine (SAH). | 20035856 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. | 20038729 |
| SF3B1 wt Allele | Epigenetic Alterations | DNA methylation predicts overall and progression-free survival in MDS. | 20038729 |
| SF3B1 wt Allele | Epigenetic Alterations | Epigenetic therapy using decitabine, a DNA hypomethylating agent, is clinically effective for the treatment of MDS. | 20038729 |
| Inflammation | Epigenetic Alterations | We hypothesized that chronic inflammation is associated with altered DNA methylation levels within the PTGS2 promoter, with effects on COX-2 mRNA expression. | 20042743 |
| Inflammation | Epigenetic Alterations | These findings suggest that the chronic persistence of the biofilm and inflammation may be associated with epigenetic changes in local tissues at the biofilm-gingival interface. | 20042743 |
| Primary malignant neoplasm | Epigenetic Alterations | The polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis. | 20044760 |
| Helicobacter-associated gastritis | Epigenetic Alterations | The gastric epithelium genome undergoes extensive epigenetic alterations during Helicobacter pylori-induced gastritis. | 20044995 |
| Infection caused by Helicobacter pylori, gastritis h pylori | Epigenetic Alterations | We characterized expression of MGMT and its epigenetic regulation via CpG methylation in gastric tissue from patients with H pylori gastritis and investigated the effects of H pylori infection eradication on MGMT expression. | 20044995 |
| Acute leukemia | Epigenetic Alterations | Deficient histone acetylation in acute leukemia and the correction by an isothiocyanate. | 20051681 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Histone acetylation was up-regulated in the presence of PHI, revealing an excess of deacetylation activity in AML. | 20051681 |
| Acute leukemia | Epigenetic Alterations | Deficient histone acetylation may represent an aberration at the epigenetic level in acute leukemia. | 20051681 |
| Acute leukemia | Epigenetic Alterations | Acetylation of histones H3 and H4 was virtually undetectable or significantly lower in acute leukemia. | 20051681 |
| Childhood Leukemia | Epigenetic Alterations | PHI might represent a target for correcting deficient acetylation, and potential epigenetic regulators for preventing the progression of leukemia. | 20051681 |
| Malignant tumor of colon | Epigenetic Alterations | Hormone therapy, DNA methylation and colon cancer. | 20064828 |
| ovarian neoplasm | Epigenetic Alterations | Our previous study showed that ADAM19, a SMAD4 target gene, is downregulated through epigenetic mechanisms in ovarian cancer with aberrant TGF-beta/SMAD4 signaling. | 20065949 |
| ovarian neoplasm | Epigenetic Alterations | FBXO32 methylation was observed in ovarian cancer cell lines displaying constitutive TGF-beta/SMAD4 signaling, and epigenetic drug treatment restored FBXO32 expression in ovarian cancer cell lines regardless of FBXO32 methylation status, suggesting that epigenetic regulation of this gene in ovarian cancer may be a common event. | 20065949 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA expression differentiates histology and predicts survival of lung cancer. | 20068076 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | MicroRNA microarray expression profiling in human myocardial infarction. | 20075508 |
| Primary malignant neoplasm | Epigenetic Alterations | In addition, histone acetylation levels in the promoter regions of CTA genes were high in cancer stem cells and low in differentiated cells, while DNA methylation analysis of the promoter regions revealed hypomethylation in cancer stem cells. | 20082319 |
| Neoplasms | Epigenetic Alterations | This epigenetic difference between cells leads to heterogeneous expression of CTA genes in the tumor mass, which consists of cells at various levels of differentiation. | 20082319 |
| Mantle cell lymphoma | Epigenetic Alterations | microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. | 20086245 |
| Medial collateral ligament | Epigenetic Alterations | Here, we performed miRNA expression profile in 30 patients with MCL using a platform containing 515 human miRNAs. | 20086245 |
| Malignant Neoplasms | Epigenetic Alterations | Thus, our findings provide not only miRNA expression signature but also a novel prognostic marker and pathogenetic factor for this malignancy. | 20086245 |
| Medial collateral ligament | Epigenetic Alterations | Eighteen miRNAs were down-regulated and 21 were up-regulated in MCL compared with normal B lymphocytes. | 20086245 |
| Endometrial adenocarcinoma, Neoplasms | Epigenetic Alterations | Is global DNA methylation in sporadic uterine adenocarcinomas in women a result of histological and clinical tumor advancement? | 20088395 |
| Endometrial adenocarcinoma | Epigenetic Alterations | To find out the relationship, if any between the extent of the overall genomic DNA methylation, and clinical and pathological features of the sporadic endometrial adenocarcinomas in women. | 20088395 |
| Primary malignant neoplasm | Epigenetic Alterations | Mean total cancer DNA methylation (3.48+/-0.46%) was significantly higher than that of the normal proliferative endometrium (2.94+/-0.4%, p=0.003) and lower than that of the secretory endometrium DNAs (3.75+/-0.47%, p=0.03). | 20088395 |
| Neoplasms | Epigenetic Alterations | Lower levels of DNA methylation seemed to be associated with diminished tumor invasiveness. | 20088395 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Our results suggest that alterations in overall DNA methylation seem to be a result of neoplastic transformation and could therefore be used as a prognostic molecular marker of endometrial cancer. | 20088395 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | To assess the effect of methylation in tumor multiplicity in sporadic CRC, hypermethylation of key tumor suppressor genes was evaluated in patients with both multiple and solitary tumors, as a proof-of-concept of an underlying epigenetic defect. | 20098741 |
| Clinical Coordinator | Epigenetic Alterations | This underlying epigenetic defect may have noteworthy implications in the prevention of patients with sporadic CRC. | 20098741 |
| Thrombocytopenic purpura, Autoimmune Diseases | Epigenetic Alterations | Epigenetics might contribute to autoimmune diseases including immune thrombocytopenic purpura (ITP). | 20100009 |
| Mismatch Repair Deficiency, Hereditary Nonpolyposis Colorectal Cancer | Epigenetic Alterations | Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. | 20102720 |
| Malignant Neoplasms, Childhood Leukemia | Epigenetic Alterations | MicroRNAs (miRNAs) are small ( approximately 22 nucleotide) non-coding RNAs whose altered expression has been associated with various types of cancers, including leukemia. | 20110180 |
| Acute leukemia | Epigenetic Alterations | MicroRNAs expression signatures are associated with lineage and survival in acute leukemias. | 20110180 |
| MICROPHTHALMIA, SYNDROMIC 7 | Epigenetic Alterations | We show that 16 miRNAs were differentially expressed between AMLs and ALLs. | 20110180 |
| cervical cancer | Epigenetic Alterations | However, dietary or pharmaceutical agents that can inhibit these epigenetic events may prevent or delay the development of cervical cancer. | 20112504 |
| Carcinogenesis | Epigenetic Alterations | Aberrant methylation of TFPI2 promoter CpG island occurred not only in GC cells but also in primary GC tissues at a high frequency, suggesting that epigenetic silencing of TFPI2 may contribute to gastric carcinogenesis. | 20113832 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Epigenetic inactivation of retinoid X receptor genes in non-small cell lung cancer and the relationship with clinicopathologic features. | 20113835 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Aberrant methylation of DNA-damage-inducible transcript 3 promoter is a common event in patients with myelodysplastic syndrome. | 20116099 |
| SF3B1 wt Allele, Neoplasms, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | The epigenetic changes of tumor suppressor genes are now recognized as an alternative mechanism contributing to the development of myelodysplastic syndrome (MDS). | 20116099 |
| Hematologic Neoplasms | Epigenetic Alterations | Epigenetic inactivation of the miR-34a in hematological malignancies. | 20118199 |
| Infection caused by Helicobacter pylori | Epigenetic Alterations | Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. | 20124475 |
| Communicable Diseases, Stomach Carcinoma, Helicobacter pylori | Epigenetic Alterations | Altered patterns of DNA methylation associated with Helicobacter pylori (HP) infection of gastric epithelial cells are thought to contribute to gastric cancer risk. | 20124475 |
| Communicable Diseases, Stomach Carcinoma | Epigenetic Alterations | In this study, we sought to clarify mechanisms in a gerbil model of gastric cancer where we showed that HP infection is causally involved in induction of aberrant DNA methylation. | 20124475 |
| Communicable Diseases | Epigenetic Alterations | Our findings argue that DNA methylation alterations that occur in gastric mucosae after HP infection are composed of transient components and permanent components, and that it is the infection-associated inflammatory response, rather than HP itself, which is responsible for inducing the altered DNA methylation. | 20124475 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells. | 20124482 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. | 20131257 |
| Disease | Epigenetic Alterations | Aberrant posttranscriptional regulation of matrix metalloproteinases (MMPs) by microRNA has emerged as an important factor in human diseases. | 20131257 |
| Degenerative polyarthritis | Epigenetic Alterations | In IL-1beta-stimulated OA chondrocytes, 42 microRNA were down-regulated, 2 microRNA were up-regulated, and the expression of 308 microRNA remained unchanged. | 20131257 |
| Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation is involved in colon carcinogenesis. | 20131317 |
| Colorectal Carcinoma, Neoplasms | Epigenetic Alterations | Although the CpG island methylator phenotype (CIMP) is defined as a subset of colorectal cancers (CRCs) with remarkably high levels of DNA methylation, it is not known whether epigenetic processes are also involved in CIMP-negative tumors. | 20131317 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Surprisingly, NCX2 could be activated by addition of the DNA methylation inhibitor 5-aza-2-deoxycytidine to glioma cell lines in which NCX2 was completely silent. | 20132488 |
| Glioma | Epigenetic Alterations | Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas. | 20132488 |
| Breast Carcinoma | Epigenetic Alterations | Circulating microRNAs as novel minimally invasive biomarkers for breast cancer. | 20134314 |
| Breast Carcinoma, Mammary Neoplasms | Epigenetic Alterations | We report that cancer-specific miRNAs were detected and significantly altered in the circulation of breast cancer patients, and that increased systemic miR-195 levels in breast cancer patients were reflected in breast tumors. | 20134314 |
| Breast Carcinoma | Epigenetic Alterations | These findings suggest that systemic miRNAs have potential use as novel breast cancer biomarkers and may prove useful in clinical management during the perioperative period. | 20134314 |
| Colorectal Cancer Pathway | Epigenetic Alterations | While these data confirm the detection rate of SEPT9 as a biomarker for colorectal cancer, they also show that methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9. | 20140221 |
| Primary malignant neoplasm | Epigenetic Alterations | Abberant DNA methylation at CpG dinucleotides represents a common mechanism of transcriptional silencing in cancer. | 20144234 |
| Oropharyngeal Route of Drug Administration, Hypopharyngeal Cancer | Epigenetic Alterations | No major difference was detected in miRNA profiles among laryngeal, oropharyngeal, or hypopharyngeal cancers. | 20145181 |
| Squamous cell carcinoma of the head and neck, Molecular Abnormality | Epigenetic Alterations | Further detailed examinations of miRNAs will provide opportunities to dissect the complex molecular abnormalities driving HNSCC progression. | 20145181 |
| Glioma | Epigenetic Alterations | Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades. | 20150384 |
| Refractory Cytopenia of Childhood, Renal Cell Carcinoma Pathway | Epigenetic Alterations | We used high-density gene expression microarrays in a functional epigenetic study of 11 renal cell carcinoma (RCC) cell lines. | 20154727 |
| Carcinoma of lung | Epigenetic Alterations | Epigenetic inactivation of the thyroid hormone receptor beta1 gene at 3p24.2 in lung cancer. | 20155399 |
| Carcinoma of lung | Epigenetic Alterations | This is the first study to demonstrate epigenetic inactivation of TRbeta1 through aberrant methylation in lung cancer, while TRbeta1 mutations are not common in lung cancer. | 20155399 |
| Mesothelioma | Epigenetic Alterations | Moreover, major epigenetic regulation of mesothelioma is mediated by hsa-miR-29c* and was shown through downregulation of DNA methyltransferases as well as upregulation of demethylating genes. | 20160038 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | We have recently identified down-regulated microRNAs including miR-145 and miR-133a in bladder cancer (BC). | 20160723 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | MicroRNA miR-1 is up-regulated in remote myocardium in patients with myocardial infarction. | 20163779 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA) plays a critical role in tumorigenesis, but it is still unknown if variants in miRNA genes lead to predisposition to cancer. | 20167074 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Considering the fact that miRNA regulates a number of tumor suppressor genes (TSGs) and oncogenes, genetic variations in miRNA genes could affect the levels of expression of TSGs or oncogenes and, thereby, cancer risk. | 20167074 |
| ovarian neoplasm | Epigenetic Alterations | To test this hypothesis in familial ovarian cancer, we screened for genetic variants in thirty selected miRNA genes, which are predicted to regulate key ovarian cancer genes and are reported to be misexpressed in ovarian tumor tissues, in eighty-three patients with familial ovarian cancer. | 20167074 |
| Glioblastoma Multiforme | Epigenetic Alterations | Epigenetic silencing of the MGMT gene by promoter methylation is associated with loss of MGMT expression, diminished DNA-repair activity and longer overall survival in patients with glioblastoma who, in addition to radiotherapy, received alkylating chemotherapy with carmustine or temozolomide. | 20167086 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | To address this question, we compared the level of their expression with the DNA methylation and histone acetylation status of 5 sequences of both genes in leukemic cell lines and primitive (lin-CD34+) leukemic cells from chronic phase CML patients. | 20175919 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | In contrast, we found a strong relation between CD7 expression and transcription-permissive chromatin modifications, both at the level of DNA methylation and histone acetylation with evidence of hypomethylation of the CD7 promoter region in the lin-CD34+ cells from CML patients with high CD7 expression. | 20175919 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia. | 20175919 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | These findings indicate a link between epigenetic modifications and CD7 expression in primitive CML cells. | 20175919 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genetic modulation of the Let-7 microRNA binding to KRAS 3-untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab-irinotecan. | 20177422 |
| Neoplasms | Epigenetic Alterations | There is increasing evidence that the Let-7 microRNA (miRNA) exerts an effect as a tumor suppressor by targeting the KRAS mRNA. | 20177422 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic alterations including changes to cellular DNA methylation levels contribute to carcinogenesis and may serve as powerful biomarkers of the disease. | 20179218 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | This investigation sought to determine whether hypomethylation at the long interspersed nuclear elements (LINE1), reflective of the level of global DNA methylation, in peripheral blood-derived DNA is associated with increased risk of bladder cancer. | 20179218 |
| Carcinoma, Ovarian Epithelial | Epigenetic Alterations | DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines. | 20179752 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | This study applied recently developed methods for high-throughput DNA methylation profiling to characterize ovarian cancer cell lines and tumors, including representatives of three major histologies. | 20179752 |
| Epithelial tumor of ovary, ovarian neoplasm | Epigenetic Alterations | We obtained DNA methylation profiles of 1,505 CpG sites (808 genes) in 27 primary epithelial ovarian tumors and 15 ovarian cancer cell lines. | 20179752 |
| ovarian neoplasm | Epigenetic Alterations | We found that the DNA methylation profiles of ovarian cancer cell lines were markedly different from those of primary ovarian tumors. | 20179752 |
| ovarian neoplasm | Epigenetic Alterations | Aggregate DNA methylation levels of the assayed CpG sites tended to be higher in ovarian cancer cell lines relative to ovarian tumors. | 20179752 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | In conclusion, KLK10 acts as a functional tumor suppressor gene in NSCLC, epigenetic inactivation of KLK10 is a common event contributing to NSCLC pathogenesis and may be used as a potential biomarker. | 20180809 |
| Primary malignant neoplasm | Epigenetic Alterations | Previous studies have suggested that microRNAs (miRNAs) may play important roles in tumorigenesis, but little is known about the functions of most miRNAs in cancer development. | 20180843 |
| Malignant Neoplasms | Epigenetic Alterations | It involves a very frequent epigenetic event that is found in many human cancers. | 20186007 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs are short noncoding RNAs that regulate multiple mRNAs and are frequently dysregulated in cancer. | 20187102 |
| Malignant neoplasm of stomach | Epigenetic Alterations | DNA methylation patterns of ulcer-healing genes associated with the normal gastric mucosa of gastric cancers. | 20191040 |
| Gastric mucosa | Epigenetic Alterations | Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. | 20191040 |
| Adenocarcinoma, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Most likely, genetic and epigenetic mechanisms might be responsible for transcriptional inactivation of RBSP3 in non-small cell lung cancers as promoter methylation of RBSP3 according to NotI microarrays data was detected in 80% of squamous cell and in 38% of adenocarcinomas. | 20193080 |
| Neoplasms | Epigenetic Alterations | Both genetic and epigenetic mechanisms contribute to down-regulation of these three genes representing two tumor suppressor clusters in 3p21.3. | 20193080 |
| Alzheimers Disease", Neurodegenerative Disorders | Epigenetic Alterations | Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3. | 20202123 |
| Epidermal cells | Epigenetic Alterations | Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer. | 20210522 |
| Malignant Neoplasms | Epigenetic Alterations | Dysregulation of microRNA (miRNA) metabolism has been observed in a variety of human cancers. | 20210522 |
| Epidermal cells | Epigenetic Alterations | Therefore, we favor the hypothesis that miRNAs are involved in the carcinogenesis of epithelial skin cancer. | 20210522 |
| Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation of HOXD3 as a marker of prostate cancer progression. | 20212450 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation in gene promoters causes gene silencing and is a common event in cancer development and progression. | 20212450 |
| Cardiovascular Diseases | Epigenetic Alterations | miRNAs (microRNAs) participate in many diseases including cardiovascular disease. | 20218970 |
| Astrocytoma | Epigenetic Alterations | Our results suggest a great potential for the use of miRNA profiling as a powerful diagnostic and prognostic marker in defining the signature of astrocytomas and in predicting the post-surgical outcome. | 20219352 |
| Malignant Neoplasms, Disease | Epigenetic Alterations | The aberrant expression of microRNAs (miRNAs) is associated with a variety of diseases including cancers. | 20219352 |
| Astrocytoma | Epigenetic Alterations | We screened the expression profile of 200 miRNAs in a training sample set consisting of 84 astrocytoma samples and 20 normal adjacent tissue (NAT) samples using the method of stem-loop quantitative RT-PCR. | 20219352 |
| Astrocytoma | Epigenetic Alterations | The significantly altered miRNAs were validated in another independent sample set consisting of 40 astrocytoma samples and 40 NAT samples. | 20219352 |
| Astrocytoma | Epigenetic Alterations | After a two-phase selection and validation process, seven miRNAs were found to have a significantly different expression profile in astrocytoma samples upon comparison to the NAT samples. | 20219352 |
| Primary malignant neoplasm | Epigenetic Alterations | Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. | 20219944 |
| S100A4 protein, human | Epigenetic Alterations | These findings shed substantial novel insights into the epigenetic effects of aging and support the view that age may predispose to malignant transformation by irreversibly stabilizing stem cell features. | 20219944 |
| Neoplasms | Epigenetic Alterations | Analyzing DNA methylation of 25 CpG sites within 960 bp around the transcription initiation site of the SERPINE1 gene by bisulfite sequencing, we did the surprising observation that both tumors and tumor-adjacent normal tissue had a significant level of methylation, whereas there was very little methylation in tissue from healthy volunteers, suggesting that tumor-adjacent normal tissue already contains transformation-associated epigenetic changes. | 20222049 |
| Squamous cell carcinoma | Epigenetic Alterations | Epigenetic alterations of the SERPINE1 gene in oral squamous cell carcinomas and normal oral mucosa. | 20222049 |
| Carcinogenesis, Infection caused by Helicobacter pylori | Epigenetic Alterations | Epigenetic inactivation of GATA-4 (and GATA-5) by methylation of CpG islands is an early frequent event during gastric carcinogenesis and is significantly correlated with H. pylori infection. | 20222162 |
| Malignant Neoplasms, Disease | Epigenetic Alterations | MicroRNAs (miRNAs) are a class of small non-coding RNAs regulating gene expression that play roles in the pathogenesis of human diseases, including malignancy. | 20223231 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). | 20223231 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | miR-21, a commonly overexpressed miRNA in very diverse types of malignancies, may affect tumor progression through targeting tumor suppressor genes. | 20223231 |
| Neoplasms | Epigenetic Alterations | Molecular detection of B-cell neoplasms by specific DNA methylation biomarkers. | 20224725 |
| Lymphoid leukemia, Neoplasms | Epigenetic Alterations | A novel, easy to perform PCR-based method employing specific DNA methylation biomarkers to detect B-cell neoplasms in a variety of B-cell lines and B lymphoblastic leukemia (B-ALL) patient specimens has been developed. | 20224725 |
| Breast Carcinoma, SCGB3A1 wt Allele | Epigenetic Alterations | A quantitative methylation-specific PCR assay was used to analyze the DNA methylation status of 6 genes (DAPK, TWIST, HIN-1, RASSF1A, RARbeta2 and APC) in 9 normal breast tissue samples from unaffected women and in 56 paired cancerous and normal tissue samples from breast cancer patients. | 20226036 |
| Mammary Neoplasms | Epigenetic Alterations | These data indicated that LOH and aberrant DNA methylation might be the possible reasons of the decreased expression of beclin 1 in the breast tumors. | 20230646 |
| Mammary Neoplasms | Epigenetic Alterations | Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors. | 20230646 |
| Malignant neoplasm of mouth | Epigenetic Alterations | Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer. | 20233326 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted. | 20300172 |
| Squamous cell carcinoma of the head and neck, Neoplasms | Epigenetic Alterations | Solid tumors, including head and neck squamous cell carcinomas (HNSCC), arise as a result of genetic and epigenetic alterations in a sustained stress environment. | 20300172 |
| Neoplasms | Epigenetic Alterations | We have extended a prior analysis of 1,413 cancer-associated loci for epigenetic changes in HNSCC by integrating DNA copy number alterations, measured at 500,000 polymorphic loci, in a case series of 19 primary HNSCC tumors. | 20300172 |
| Primary malignant neoplasm, Loss of Heterozygosity | Epigenetic Alterations | This work, using a novel and robust statistical approach demonstrates that, although a "second hit" mechanism is not likely the predominant mode of action for epigenetic dysregulation in cancer, the patterns of methylation events are associated with the patterns of allele loss. | 20300172 |
| Cardiovascular Diseases | Epigenetic Alterations | DNA methylation as a biomarker for cardiovascular disease risk. | 20300621 |
| Obesity | Epigenetic Alterations | Our findings indicate that elevated, not decreased, PBL DNA methylation is positively associated with prevalence of CVD/predisposing conditions and obesity in Singapore Chinese. | 20300621 |
| Neoplasm Metastasis | Epigenetic Alterations | MicroRNAs play key roles in tumor metastasis. | 20300657 |
| Barrett Esophagus | Epigenetic Alterations | MicroRNA profiling of Barretts oesophagus and oesophageal adenocarcinoma. | 20301167 |
| Primary malignant neoplasm | Epigenetic Alterations | The aberrant expression of microRNAs (miRNAs) is involved in the development of cancer. | 20301167 |
| melanoma, Inflammation | Epigenetic Alterations | Our findings, although preliminary, support the notion that the differential biology of melanoma at the extremes of age is driven, in part, by deregulation of microRNA expression and by fine tuning of miRs that are already known to regulate cell cycle, inflammation, Epithelial-Mesenchymal Transition (EMT)/stroma and more specifically genes known to be altered in melanoma. | 20302635 |
| Arteriosclerosis | Epigenetic Alterations | Lower blood DNA methylation has been associated with atherosclerosis and high cardiovascular risk. | 20305373 |
| Cardiovascular Diseases | Epigenetic Alterations | Our data provide new insights into epigenetic events that may accompany the development of cardiovascular disease. | 20305373 |
| Liver carcinoma | Epigenetic Alterations | Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. | 20305825 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | Our study shows that HCC tumors exhibit specific DNA methylation signatures associated with major risk factors and tumor progression stage, with potential clinical applications in diagnosis and prognosis. | 20305825 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Hepatocellular carcinoma (HCC) is characterized by late detection and fast progression, and it is believed that epigenetic disruption may be the cause of its molecular and clinicopathological heterogeneity. | 20305825 |
| Carcinogenesis, Esophageal carcinoma | Epigenetic Alterations | Altered microRNA (miRNA) expression has been found to promote carcinogenesis, but little is known about the role of miRNAs in esophageal cancer. | 20309880 |
| Esophageal carcinoma | Epigenetic Alterations | Prognostic significance of differentially expressed miRNAs in esophageal cancer. | 20309880 |
| Esophageal carcinoma | Epigenetic Alterations | In this study, we selected 10 miRNAs and analyzed their expression in 10 esophageal cancer cell lines and 158 tissue specimens using Northern blotting and in situ hybridization, respectively. | 20309880 |
| Neoplasms | Epigenetic Alterations | Genetic and epigenetic data indicate oncogenic or tumor suppressor function of these pleiotropic regulators. | 20331864 |
| Breast Carcinoma | Epigenetic Alterations | However, nothing is known so far about microRNA expression in male breast cancer, accounting for approximately 1% of all breast cancer cases. | 20331864 |
| Breast Carcinoma | Epigenetic Alterations | Not all of them are shared with breast cancer biopsies from female patients indicating male breast cancer specific alterations of microRNA expression. | 20331864 |
| Breast Carcinoma | Epigenetic Alterations | Identification of differentially expressed microRNAs in human male breast cancer. | 20331864 |
| Breast Carcinoma | Epigenetic Alterations | Male breast cancer displays several differentially expressed microRNAs. | 20331864 |
| Carcinoma, Ovarian Epithelial | Epigenetic Alterations | [Expression of microRNA-21 in ovarian epithelial carcinoma and its clinical significance]. | 20335152 |
| Mammary Neoplasms | Epigenetic Alterations | DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response. | 20338046 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Breast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics. | 20338046 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic inactivation of CADM1/TSLC1 gene is a frequent alteration in development of colorectal cancer and can be a potential biomarker for molecular staging of patients with colorectal cancer. | 20340131 |
| Infection caused by Helicobacter pylori, Carcinogenesis | Epigenetic Alterations | Role of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis. | 20345486 |
| Squamous cell carcinoma of skin | Epigenetic Alterations | Aberrant DNA methylation associated with MTHFR C677T genetic polymorphism in cutaneous squamous cell carcinoma in renal transplant patients. | 20346029 |
| Primary malignant neoplasm | Epigenetic Alterations | Changes in genomic DNA methylation associated with cancer include global DNA hypomethylation and gene-specific hyper- or hypomethylation. | 20346029 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker. | 20349219 |
| Malignant neoplasm of stomach, Neoplasms | Epigenetic Alterations | Our results indicate that the detection of miRNA in peripheral blood may be a novel tool for monitoring circulating tumor cells in patients with gastric cancers. | 20349219 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Antioxidant and DNA methylation-related nutrients and risk of distal colorectal cancer. | 20352485 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Our findings provide evidence that antioxidant and DNA methylation-related nutrients may lower the risk of distal colorectal cancer in whites, and selenium may lower risk in African Americans. | 20352485 |
| Malignant Neoplasms, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Epigenetic silencing of secreted frizzled-related protein (SFRP) genes, antagonists of the WNT pathway, contributes to the pathogenesis of several cancers including non-small cell lung cancer (NSCLC). | 20353273 |
| Carcinogenesis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In conclusion, epigenetic inactivation of SFRP1 is a common event contributing to lung carcinogenesis and maybe used as a potential biomarker for NSCLC in Chinese population. | 20353273 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients. | 20353279 |
| melanoma | Epigenetic Alterations | MicroRNA expression profiles associated with mutational status and survival in malignant melanoma. | 20357817 |
| NRAS gene, melanoma | Epigenetic Alterations | In conclusion, our findings show miRNA dysregulation in malignant melanoma and its relation to established molecular backgrounds of BRAF and NRAS oncogenic mutations. | 20357817 |
| melanoma | Epigenetic Alterations | Several miRNAs were differentially expressed between melanocytes and melanomas as well as melanoma cell lines. | 20357817 |
| Neoplasms | Epigenetic Alterations | Inhibition of RASSF2 expression enhances the transforming effects of K-Ras, and epigenetic inactivation of RASSF2 is frequently detected in mutant Ras-containing primary tumors. | 20368356 |
| Cytogenetically normal acute myeloid leukemia, Leukemia, Myelocytic, Acute | Epigenetic Alterations | The R172 IDH2 mutations, previously unreported in AML, characterize a novel subset of CN-AML patients lacking other prognostic mutations and associate with unique gene- and microRNA-expression profiles that may lead to the discovery of novel, therapeutically targetable leukemogenic mechanisms. | 20368543 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The highest expressed gene and microRNAs in R172 IDH2-mutated patients compared with the IDH1/IDH2wt patients were APP (previously associated with complex karyotype AML) and miR-1 and miR-133 (involved in embryonal stem-cell differentiation), respectively. | 20368543 |
| cervical cancer | Epigenetic Alterations | Our results suggest that TSG101 down-regulation in cervical cancer cells is not regulated by genetic or epigenetic events. | 20372822 |
| Primary malignant neoplasm | Epigenetic Alterations | Global hypomethylation is a common epigenetic event in cancer. | 20374511 |
| Cerebrovascular accident | Epigenetic Alterations | A functional variant in the 3-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211. | 20378606 |
| Malignant Neoplasms | Epigenetic Alterations | The alteration of DNA methylation is one of the most common epigenetic changes in human cancers. | 20381114 |
| Neoplasms | Epigenetic Alterations | Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changes. | 20383576 |
| Neoplasms | Epigenetic Alterations | These data suggest that diet and lifestyle factors are associated with specific types of rectal tumor mutations and epigenetic changes. | 20383576 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Therefore, we address this point by the identification of microRNAs that in non-small cell lung cancer (NSCLC) modulate PED levels. | 20388802 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Aberrant expression of microRNAs (miRNAs) has been associated with clinical outcome in patients with chronic lymphocytic leukemia (CLL). | 20393129 |
| Acute myocardial infarction | Epigenetic Alterations | Plasma microRNA 499 as a biomarker of acute myocardial infarction. | 20395621 |
| myocardial injury | Epigenetic Alterations | Recently, we reported that miRNA 208 (miR-208) is produced exclusively in the rat myocardium and that plasma miR-208 is a biomarker of myocardial injury in rats. | 20395621 |
| Malignant Neoplasms | Epigenetic Alterations | Evidence exists that microRNA (miRNA), which regulates gene expression, is frequently deregulated in cancers. | 20402672 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The increased expressions of Ago2 and TNRC6A in both PCA and ESCC compared with their normal cells suggested that over-expression of these proteins may be related to miRNA functions and might play a role in tumorigenesis of PCA and ESCC. | 20402672 |
| Liver carcinoma | Epigenetic Alterations | Epigenetic methylation and expression of caspase 8 and survivin in hepatocellular carcinoma. | 20403046 |
| Hollings Cancer Center | Epigenetic Alterations | In conclusion, epigenetic alteration by promoter methylation of caspase 8 and survivin may constitute an important regulatory mechanism for expression of those genes in HCC. | 20403046 |
| Malignant Neoplasms | Epigenetic Alterations | Micro-RNAs (miRNAs) are involved in the pathogenesis of diverse human cancers, including PTC. | 20406109 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Expression, epigenetic regulation, and humoral immunogenicity of cancer-testis antigens in chronic myeloid leukemia. | 20409582 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | Association of microRNA expression with microsatellite instability status in colorectal adenocarcinoma. | 20413677 |
| Clinical Coordinator | Epigenetic Alterations | When miRNA expression was compared with clinicopathologic features and MSI status, eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203, -133b, and -223) were over-expressed in CRC relative to mucosa, and nine (miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC. | 20413677 |
| Clinical Coordinator, Malignant Neoplasms | Epigenetic Alterations | Our findings indicate that miRNA expression in CRC is associated with MSI subgroups, including low MSI and HNPCC-associated cancers, and that miRNAs may have posttranscriptional gene regulatory roles in these MSI subgroups and possible effects on the clinicopathologic and biomarker characteristics. | 20413677 |
| Non-Cancer Related Death, ovarian neoplasm, Serous cystadenoma, borderline malignancy | Epigenetic Alterations | Its methylation can be used as a novel epigenetic biomarker in discriminating ovarian cancer from non-cancer or borderline tumors. | 20421128 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic regulation of Wnt signaling pathway in urological cancer. | 20421722 |
| Bladder Neoplasm | Epigenetic Alterations | We concluded that epigenetic deregulation of Wnt pathway inhibitors may contribute to aberrant activation of Wnt signaling pathway in bladder, prostate and renal tumors. | 20421722 |
| Clinical Coordinator, Colorectal Carcinoma, Neoplasms | Epigenetic Alterations | Recent findings suggest that epigenetic inactivation of multiple tumor suppressor genes plays an important role in the tumorigenesis of colorectal carcinoma (CRC). | 20423473 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Differential expression of specific microRNA and their targets in acute myeloid leukemia. | 20425795 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | We showed that miRNA expression profiling reveals distinctive miRNA signatures that correlate with cytogenetic and molecular subtypes of AML. | 20425795 |
| FLT3 Internal Tandem Duplication, nucleophosmin, Leukemia, Myelocytic, Acute | Epigenetic Alterations | We observed a significant differentially expressed miRNA profile that characterizes two subgroups of AML with different mechanism of leukemogenesis: core binding factor (CBF) and cytogenetically normal AML with mutations in the genes of NPM1 and FLT3-ITD. | 20425795 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | We demonstrated, for the first time, the inverse correlation of expression levels between miRNA and their targets in specific AML genetic groups. | 20425795 |
| Malignant Neoplasms | Epigenetic Alterations | Altered expression of miRNA is known to induce various human malignancies. | 20428818 |
| Malignant Neoplasms, Squamous cell carcinoma of esophagus | Epigenetic Alterations | MiR-21, which is an oncogenic miRNA in various malignancies, was also up-regulated in HNSCC and ESCC compared to paired normal squamous epithelia. | 20428818 |
| Squamous cell carcinoma, Squamous cell carcinoma of esophagus | Epigenetic Alterations | These results suggest that miR-205 might be a specific marker miRNA of both normal and malignant squamous epithelia, while miR-21 might be a putative oncogenic miRNA in HNSCC and ESCC. | 20428818 |
| Squamous cell carcinoma, Squamous cell carcinoma of the head and neck, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC. | 20428818 |
| Squamous cell carcinoma, Malignant Neoplasms, Squamous cell carcinoma of esophagus | Epigenetic Alterations | We examined the expression of miRNAs in squamous cell carcinoma of human head and neck (HNSCC) and esophagus (ESCC), compared to that in normal squamous epithelia as well as malignancies of other organs. | 20428818 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer. | 20429937 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | We adopt and report a systematic approach to identify the most stable reference genes for miRNA expression studies by RT-qPCR in colorectal cancer (CRC). | 20429937 |
| Clinical Coordinator | Epigenetic Alterations | High-throughput miRNA profiling was performed on ten pairs of CRC and normal tissues. | 20429937 |
| Neoplasms | Epigenetic Alterations | As such the stability of a panel of miRNAs was examined on 35 tumour and 39 normal tissues. | 20429937 |
| Neoplasms | Epigenetic Alterations | The effects of normalisers on the relative quantity of established oncogenic (miR-21 and miR-31) and tumour suppressor (miR-143 and miR-145) target miRNAs were assessed. | 20429937 |
| Neoplasms | Epigenetic Alterations | The combined use of miR-16 and miR-345 to normalise expression data enabled detection of a significant dysregulation of all four target miRNAs between tumour and normal colorectal tissue. | 20429937 |
| Carcinogenesis | Epigenetic Alterations | Analysis of DNA methylation status of the promoter of human telomerase reverse transcriptase in gastric carcinogenesis. | 20430247 |
| Neoplasms | Epigenetic Alterations | Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors. | 20432164 |
| melanoma | Epigenetic Alterations | Signatures of microRNAs and selected microRNA target genes in human melanoma. | 20442294 |
| melanoma | Epigenetic Alterations | Because data presently available on miRNA expression in melanoma are inconsistent thus far, we applied several different miRNA detection and profiling techniques on a panel of 10 cell lines and 20 patient samples representing nevi and primary or metastatic melanoma. | 20442294 |
| melanoma | Epigenetic Alterations | Nevertheless, we identified miRNA-200c to be consistently downregulated in melanocytes, melanoma cell lines, and patient samples, whereas miRNA-205 and miRNA-23b were markedly reduced only in patient samples. | 20442294 |
| melanoma | Epigenetic Alterations | Our findings define miRNAs and miRNA target genes that offer candidate biomarkers in human melanoma. | 20442294 |
| palladium | Epigenetic Alterations | Methylation of SNCA intron 1 was reduced in DNA from sporadic PD patients substantia nigra, putamen, and cortex, pointing toward a yet unappreciated epigenetic regulation of SNCA expression in PD. | 20445061 |
| Malignant Neoplasms, Lymphoma, Non-Hodgkin, Lymphoma, Large-Cell, Follicular, Chronic Lymphocytic Leukemia | Epigenetic Alterations | Targeting aberrant DNA hypermethylation in chronic lymphocytic leukaemia (CLL) and non-Hodgkin lymphoma (NHL) with decitabine may reverse epigenetic silencing in B-cell malignancies. | 20456354 |
| Esophageal carcinoma | Epigenetic Alterations | [Genetic and epigenetic changes of FHIT gene in patients with esophageal cancer]. | 20458975 |
| Obesity, Esophageal carcinoma | Epigenetic Alterations | Associations of risk factors obesity and occupational airborne exposures with CDKN2A/p16 aberrant DNA methylation in esophageal cancer patients. | 20459442 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Quantitative epigenetic subclassification of rectal cancers has clinical utility in distinguishing tumors with increased risk for local recurrence and may help tailor treatment regimens for locoregional control. | 20460484 |
| ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | MicroRNA-21 (miR-21) was reported to be overexpressed and contributes to invasion and gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC). | 20460539 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | We found that imatinib treatment of chronic myeloid leukemia patients rapidly normalizes the characteristic miRNA expression profile, suggesting that miRNAs may serve as a novel clinically useful biomarker in this disease. | 20460641 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia. | 20460641 |
| Malignant Neoplasms, Myeloid Leukemia, Chronic | Epigenetic Alterations | Aberrant expression of miRNAs has been described in many human cancers, including chronic myeloid leukemia. | 20460641 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Expression changes in the same miRNAs were consistently found in an additional cohort of chronic myeloid leukemia patients, as compared to healthy subjects. | 20460641 |
| Breast Carcinoma, Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | The quantitative detection of aberrant DNA methylation in serum samples may be a promising high throughput approach for the diagnosis of breast cancer including DCIS. | 20466412 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition. | 20467341 |
| diabetic | Epigenetic Alterations | Autopsy pancreas samples from 40 type 2 diabetic and 15 nondiabetic patients were used to detect microRNA-375 expression using real-time quantitative polymerase chain reaction. | 20467341 |
| diabetic | Epigenetic Alterations | Pancreatic microRNA-375 expression was increased in type 2 diabetic patients comparing with the nondiabetic patients (median, 4.02 for the diabetic patients vs 0.92 for the nondiabetic patients; P = 0.0001). | 20467341 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Up-regulated microRNA-375 is associated with type 2 diabetes and pancreatic islet amyloid formation and beta-cell deficit. | 20467341 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Epigenetic Alterations | microRNA-375 may serve as a biomarker for known and novel pathways in the pathogenesis of type 2 diabetes related to islet amyloid deposition and beta-cell dysfunction. | 20467341 |
| Degenerative polyarthritis, Rheumatoid Arthritis | Epigenetic Alterations | Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. | 20470394 |
| Degenerative polyarthritis | Epigenetic Alterations | The expression patterns of miRNAs in synovial fluid of OA were similar to miRNAs secreted by synovial tissues. | 20470394 |
| Right arm | Epigenetic Alterations | Synovial fluid miRNAs of RA were likely to originate from synovial tissues and infiltrating cells. | 20470394 |
| Degenerative polyarthritis, Right arm | Epigenetic Alterations | Plasma miR-132 well differentiated HCs from patients with RA or OA, while synovial fluid miRNAs differentiated RA and OA. | 20470394 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Our study underscores the potential utility of DNA methylation of these genes in serum as a promising biomarker and can serve as a surrogate for tumor DNA methylation for diagnosis and prognosis of breast cancer. | 20470789 |
| Parkinson Disease, FGF20 protein, human | Epigenetic Alterations | FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinsons disease in Spanish patients. | 20471450 |
| Breast Carcinoma, Neoplastic disease, Neoplasms | Epigenetic Alterations | Silencing tumor suppressor genes via DNA methylation has established hypermethylation as one of the most frequent molecular alterations that may initiate and drive many types of human neoplasia including breast cancer. | 20471512 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA. | 20471512 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Detecting such epigenetic changes in DNA derived not only from tumor tissue, but also from bodily fluids, may be a promising target for the molecular analysis of cancer. | 20471512 |
| Primary malignant neoplasm | Epigenetic Alterations | Abnormal DNA methylation is a feature of most types of cancer, which is reflected in cell-free circulating DNA in plasma. | 20473856 |
| Neoplasms | Epigenetic Alterations | It is, however, unknown whether surgical removal of the tumor and subsequent therapy induces changes in plasma DNA methylation, which can be used to monitor treatment. | 20473856 |
| Colorectal Cancer Pathway, Lynch Syndrome | Epigenetic Alterations | De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one. | 20473912 |
| Lynch Syndrome | Epigenetic Alterations | Constitutional epimutations of the MLH1 gene, characterized by soma-wide methylation of a single allele of the promoter and allelic transcriptional silencing, have been identified in a subset of Lynch syndrome cases lacking a sequence mutation in MLH1. | 20473912 |
| Neoplasms | Epigenetic Alterations | Analysis of 13 tumors from seven individuals with constitutional MLH1 epimutations showed eight tumors had lost the second MLH1 allele, two tumors had a novel pathogenic missense mutation and three had retained heterozygosity. | 20473912 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | In both cases, cancer had arisen because of the de novo occurrence of a constitutional MLH1 epimutation and somatic loss-of-heterozygosity of the functional allele in the tumors. | 20473912 |
| Neoplasms | Epigenetic Alterations | It is clear that the second hit in MLH1 epimutation-associated tumors typically has a genetic not epigenetic basis. | 20473912 |
| Carcinogenesis, Stomach Carcinoma | Epigenetic Alterations | Our findings demonstrate that reduced RASAL1 expression, partly due to genetic and epigenetic changes, contributes to gastric carcinogenesis, and also re-emphasize the importance of RAS signaling in gastric cancer development. | 20473946 |
| Loss of Chromosome 1p | Epigenetic Alterations | Chromosome 1p loss and epigenetic modifications were the major mechanisms contributing to PDAM downregulation. | 20477830 |
| Neoplasms | Epigenetic Alterations | Our findings also suggest that single-nucleotide polymorphisms located in the binding region of the MRE-RAD50-NBS1 complex or microRNA targeted pathways may influence tumor development. | 20478923 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. | 20479932 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | These findings provide new insights into the role of the ETS transcriptional network in prostate tumorigenesis and uncover previously unrecognized links between aberrant expression of ETS factors, deregulation of epigenetic effectors and silencing of tumor suppressor genes. | 20479932 |
| Prostate Cancer Pathway | Epigenetic Alterations | The link between aberrant ETS activity and epigenetic gene silencing may be relevant for the clinical management of prostate cancer and design of new therapeutic strategies. | 20479932 |
| Cervix carcinoma | Epigenetic Alterations | The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma. | 20482749 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic gene silencing of secreted Wnt antagonists is considered a common event in a wide range of human malignancies. | 20482749 |
| Cervix carcinoma | Epigenetic Alterations | Epigenetic silencing of KLOTHO may occur during the late phase of cervical tumorigenesis, and consequent functional loss of KLOTHO as the secreted Wnt antagonist may contribute to aberrant activation of the canonical Wnt pathway in cervical carcinoma. | 20482749 |
| Lupus Erythematosus, Systemic, Lupus Erythematosus | Epigenetic Alterations | In systemic lupus erythematosus (SLE), global and gene-specific DNA methylation changes have been demonstrated to occur. | 20483040 |
| SLC24A3 gene | Epigenetic Alterations | Aberrant DNA methylation can also be found on selected randomly positive genes (WDR5, SLC24A3, PTPN22, LRP1B METT10D and CDH13). | 20483040 |
| Lupus Erythematosus | Epigenetic Alterations | Such novel findings show the significance of H3K4me3 as a potential biomarker or promising target for epigenetic-based lupus therapies. | 20483040 |
| Chronic heart failure | Epigenetic Alterations | MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients. | 20484156 |
| Congestive heart failure | Epigenetic Alterations | The identified miRNAs might have a potential diagnostic and/or prognostic use in CHF. | 20484156 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact. | 20484983 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | We performed a genome-wide analysis of aberrant DNA methylation in chronic lymphocytic leukemia (CLL) using methylated CpG island amplification (MCA) coupled with a promoter microarray. | 20484983 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | We identified 280 potential targets of aberrant DNA methylation in CLL. | 20484983 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | This study demonstrates that aberrant DNA methylation is common and has potential prognostic and therapeutic value in CLL. | 20484983 |
| Clear cell adenocarcinoma of ovary, Ovarian Serous Adenocarcinoma, OSA protein, Drosophila, Neoplasms, Endometrioma | Epigenetic Alterations | Specific tumour suppressor genes with promoter methylation in ovarian clear cell adenocarcinoma (OCCA) can be one important epigenetic mark distinguishing OCCA from ovarian serous adenocarcinoma (OSA), benign endometriotic cysts and normal ovarian epitheliums. | 20486992 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia. | 20487546 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | XPC epigenetic silence coupled with p53 alteration has a significant impact on bladder cancer outcome. | 20488473 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Epigenetic defects in the XPC gene impact bladder cancer malignant behavior and may also predict poor outcome in some bladder cancer cases, as characterized by p53 pathway alteration. | 20488473 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Promoter methylation is a gene- and cancer type-specific epigenetic event that plays an important role in tumour development. | 20488783 |
| Endometrial Carcinoma, Endometrial Serous Adenocarcinoma, Endometrioid tumor | Epigenetic Alterations | As endometrioid (endometrioid endometrial carcinoma, EEC) and serous endometrial cancers (uterine papillary serous carcinoma, UPSC) exhibit different clinical, histological and molecular genetic characteristics, we hypothesized that these differences may be reflected in epigenetic phenomena as well. | 20488783 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer. | 20490652 |
| Breast Carcinoma | Epigenetic Alterations | We identified hsa-miRNA-30c as an independent predictor for clinical benefit of tamoxifen therapy in patients with advanced breast cancer. | 20490652 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are small RNA molecules that modulate gene expression and which have been implicated in cancer. | 20490652 |
| Mammary Neoplasms | Epigenetic Alterations | These five miRNAs were measured in an independent series of 246 estrogen receptor (ER)-positive primary breast tumors of patients who received tamoxifen for advanced disease by quantitative Real Time PCR. | 20490652 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features. | 20492682 |
| Clinical Coordinator | Epigenetic Alterations | Comprehensive DNA methylation profiling identified three CRC subgroups with distinctive clinicopathological and molecular features. | 20492682 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | The epigenetic changes of TSGs are recently recognized as an abnormal mechanism contributing to the development of chronic myeloid leukemia (CML). | 20492726 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrations of allelic replication timing are epigenetic markers observed in peripheral blood cells of cancer patients. | 20497575 |
| Hematologic Neoplasms | Epigenetic Alterations | We show that aberrant epigenetic markers are detected in patients with hematological malignancies from the time of diagnosis through to when they are scheduled to undergo alloSCT. | 20497575 |
| Aneuploidy | Epigenetic Alterations | A demethylating anti-cancer drug, 5-azacytidine, applied in vitro to lymphocytes of patients prior to transplantation mimics the effect of transplantation: the epigenetic aberrations disappear while aneuploidy stays unchanged. | 20497575 |
| Liver carcinoma | Epigenetic Alterations | [MicroRNA profiling in patients with hepatocellular carcinoma]. | 20501372 |
| Hollings Cancer Center | Epigenetic Alterations | HCC and LC samples have significantly different microRNA expression profiles. | 20501372 |
| Hollings Cancer Center | Epigenetic Alterations | Three microRNAs exhibited higher expression in the HCC samples than in the LC samples. | 20501372 |
| Hollings Cancer Center | Epigenetic Alterations | In comparison with the LC samples, the HCC samples showed down-regulated expressions of 9 microRNAs. | 20501372 |
| Hollings Cancer Center | Epigenetic Alterations | These differentially expressed microRNAs may be involved in the pathogensis of HCC. | 20501372 |
| Malignant Neoplasms, Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | MicroRNA-199a-3p (miR-199a-3p) is downregulated in several human malignancies including hepatocellular carcinoma (HCC). | 20501828 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNA) have rapidly emerged as modulators of gene expression in cancer in which they may have great diagnostic and therapeutic import. | 20501828 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia. | 20504344 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | To elucidate whether microRNAs are involved in the development of fludarabine resistance, we analyzed the expression of 723 human miRNAs before and 5-days after fludarabine mono-therapy in 17 CLL patients which were classified as responder or refractory to fludarabine treatment based on NCI criteria. | 20504344 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | The expression of some microRNAs was also able to predict fludarabine resistance of 12 independent CLL patients. | 20504344 |
| Breast Carcinoma | Epigenetic Alterations | These results suggest that gene methylation in breast cancer can potentially serve as epigenetic biomarkers and may contribute further to current breast cancer classification. | 20505321 |
| Stomach Carcinoma | Epigenetic Alterations | DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae. | 20507321 |
| Stomach Carcinoma | Epigenetic Alterations | Our findings indicate that epigenetic IRF inactivation plays a key role in tumorigenesis of gastric cancer, and that inhibition of DNA methylation may restore the antitumor activity of interferons through up-regulation of IRFs. | 20507321 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | De novo DNA methylation is a relevant epigenetic mechanism, which represses gene transcription and commonly inactivates tumor suppressor genes in carcinogenesis. | 20514408 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation is aberrant in breast cancer and is likely to play a major role in disease progression. | 20515469 |
| Breast Carcinoma, Hormone Receptor Positive Breast Carcinoma | Epigenetic Alterations | In this study, the DNA methylation status of 202 candidate loci was screened to identify those loci that may predict outcome in LNP/estrogen receptor-positive (ER+) breast cancer patients with adjuvant anthracycline-based chemotherapy. | 20515469 |
| Breast Carcinoma | Epigenetic Alterations | Quantitative bisulfite sequencing was used to analyze DNA methylation biomarker candidates in a retrospective cohort of 162 LNP/ER+ breast cancer patients, who received adjuvant anthracycline-based chemotherapy. | 20515469 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Growing evidence suggests that miRNAs have a significant role in tumor development and may constitute robust biomarkers for cancer diagnosis and prognosis. | 20518884 |
| Gallbladder Carcinoma | Epigenetic Alterations | Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population. | 20520619 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) play critical roles in embryonic development and are frequently deregulated in human cancers. | 20525879 |
| Primary malignant neoplasm | Epigenetic Alterations | The let-7 family members are tumor-suppressing miRNAs and are frequently downregulated in cancer cells. | 20525879 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers. | 20526284 |
| Carcinoma of lung | Epigenetic Alterations | We have previously shown that microRNAs (miRNAs) were stably present in sputum and potentially useful in diagnosis of lung cancer. | 20526284 |
| Neoplasms | Epigenetic Alterations | On the surgical tissues, six miRNAs were identified, of which three were overexpressed and three were underexpressed in all 15 tumors. | 20526284 |
| Carcinogenesis | Epigenetic Alterations | Multiple genetic and epigenetic alterations in several genes are implicated in the multistep process of human gastric carcinogenesis. | 20530453 |
| PSMG2 gene | Epigenetic Alterations | Together, these results provide a novel insight into the mechanisms involved in HCV-associated hepatocellular carcinomas, showing that reduced Gadd45beta expression may play a contributory role to this process, and providing evidence that HCV may interfere with epigenetic gene expression by altering promoter methylation. | 20530689 |
| Hematologic Neoplasms | Epigenetic Alterations | Epigenetic therapies, including DNA methyltransferase and histone deacetylase inhibitors, represent important new treatment modalities in hematologic malignancies, but their mechanism of action remains unknown. | 20530795 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Furthermore, it appears that epigenetic therapies have the capacity to induce a CTL response to MAGE antigens in vivo that may contribute to their clinical activity in AML. | 20530795 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Circulating microRNAs are new and sensitive biomarkers of myocardial infarction. | 20534597 |
| Ischemia | Epigenetic Alterations | In mice with acute hind-limb ischaemia, there was no increase in the plasma level of the above miRNAs. | 20534597 |
| Damage | Epigenetic Alterations | These miRNAs represent novel biomarkers of cardiac damage. | 20534597 |
| Helicobacter pylori | Epigenetic Alterations | Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells. | 20542134 |
| Infection caused by Helicobacter pylori | Epigenetic Alterations | MicroRNAs (miRNAs) have recently emerged as key post-transcriptional regulators of gene expression, and their role in H. pylori infection is just beginning to be explored. | 20542134 |
| Uterine Neoplasms | Epigenetic Alterations | MicroRNA signatures differentiate uterine cancer tumor subtypes. | 20542546 |
| Endometrial Serous Adenocarcinoma, Neoplasms | Epigenetic Alterations | Distinct miRNA signatures in tumor versus normal samples and in endometrioid vs. uterine papillary serous carcinomas exist. | 20542546 |
| Carcinosarcoma, Neoplasms | Epigenetic Alterations | Additionally, carcinosarcomas have a unique miRNA signature from either the type I or II epithelial tumors. | 20542546 |
| Neoplasms | Epigenetic Alterations | We hypothesize that further understanding the miRNAs that separate these subtypes of EC will lead to biological insights into the different behavior of these tumors. | 20542546 |
| Small cell carcinoma of lung | Epigenetic Alterations | MicroRNA 92a-2*: a biomarker predictive for chemoresistance and prognostic for survival in patients with small cell lung cancer. | 20548249 |
| Small cell carcinoma of lung, Neoplasms | Epigenetic Alterations | We hypothesized that tumor microRNAs (miRNAs) could serve as predictive biomarkers for chemoresistance and prognostic biomarkers for survival of patients with SCLC treated with systemic chemotherapy. | 20548249 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | As an inhibitor of cyclin-dependent kinases, p16(INK4A) is an important tumour suppressor and inducer of cellular senescence that is often inactivated during the development of cancer by promoter DNA methylation. | 20548956 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3. | 20549700 |
| Malignant Neoplasms | Epigenetic Alterations | microRNA-125b (miR-125b) was implicated to have close relationship with cell proliferation and differentiation, and downregulation of miR-125b was observed in various types of cancers. | 20549700 |
| Primary malignant neoplasm | Epigenetic Alterations | In cancer, regulation of gene transcription can be mediated in a variety of ways. | 20551037 |
| Neoplastic disease | Epigenetic Alterations | MicroRNAs (miRNA) play an important role in a wide array of biological processes and are commonly dysregulated in neoplasia. | 20551304 |
| Colorectal Neoplasms, Adenoma | Epigenetic Alterations | miRNA expression profiles from 29 patients showed higher expression of miR-21 and miR-106a in patients with adenomas and CRCs compared with individuals free of colorectal neoplasia. | 20551304 |
| Colorectal Neoplasms | Epigenetic Alterations | The stools of patients with colorectal neoplasms have unique and identifiable patterns of miRNA expression. | 20551304 |
| Malignant tumor of colon | Epigenetic Alterations | Fecal MicroRNAs as novel biomarkers for colon cancer screening. | 20551304 |
| Colorectal Neoplasms | Epigenetic Alterations | Fecal miRNAs may be an excellent candidate for the development of a noninvasive screening test for colorectal neoplasms. | 20551304 |
| Childhood Leukemia | Epigenetic Alterations | [Detection of miRNA levels in leukemia patients by real-time quantitative PCR]. | 20561445 |
| Neoplasms | Epigenetic Alterations | DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast. | 20563638 |
| Neoplasms | Epigenetic Alterations | Methylation-sensitive high resolution melting (MS-HRM) was used to screen promoter DNA methylation changes in 86 phyllodes tumours (15 benign, 28 borderline, 43 malignant) and 26 fibroadenomas. | 20563638 |
| Hematologic Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation is a hallmark of cancer, and DNA methyltransferase inhibitors have demonstrated clinical efficacy in hematologic malignancies. | 20564122 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation has been implicated as a key survival mechanism in cancer, whereby promoter hypermethylation silences genes essential for many cellular processes including apoptosis. | 20564325 |
| Neoplasms | Epigenetic Alterations | This epigenetic alteration affects promoter of genes having crucial cellular functions such as tumor suppressor, DNA repair, apoptosis, cell adhesion, etc. | 20571967 |
| Colorectal Neoplasms | Epigenetic Alterations | We also showed that epigenetic alteration of CDH1 is a major mechanism of the loss of E-cadherin protein expression in primary colorectal tumors. | 20571967 |
| Malignant Neoplasms, Breast Carcinoma, disease stage | Epigenetic Alterations | Systemic miRNA-195 differentiates breast cancer from other malignancies and is a potential biomarker for detecting noninvasive and early stage disease. | 20576643 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Data have emerged documenting altered systemic miRNA expression across a spectrum of cancers; however, it remains uncertain as to whether circulating miRNAs are tumor specific. | 20576643 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | These findings suggest that individual cancers display specific systemic miRNA profiles, which could aid in discriminating among cancer types. | 20576643 |
| Neoplasms | Epigenetic Alterations | The potential of microRNAs (miRNAs) as novel tumor markers has been the focus of recent scrutiny because of their tissue specificity, stability, and association with clinicopathological parameters. | 20576643 |
| Breast Carcinoma | Epigenetic Alterations | A combination of three circulating miRNAs, including miR-195, further enhanced the discriminative power of this test for breast cancer to 94%. | 20576643 |
| Primary malignant neoplasm | Epigenetic Alterations | This finding is of notable clinical consequence because it illustrates the potential of systemic miRNAs as sensitive, specific, noninvasive cancer biomarkers. | 20576643 |
| Acute lymphocytic leukemia | Epigenetic Alterations | 14q32/miRNA clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a. | 20578197 |
| Acute lymphocytic leukemia | Epigenetic Alterations | We demonstrate that a subset of ALL cases bearing 14q32 LOH showed a down-regulation of miRNA 14q32 clusters, which is directly linked to the submicroscopic chromosomal deletion. | 20578197 |
| Acute lymphocytic leukemia | Epigenetic Alterations | These results suggest that 14q32/miRNA clusters LOH may be another mechanism involved in lymphoid B cell transformation and differentiation and therefore, could be used as a diagnostic marker and therapeutic target in subsets of ALL. | 20578197 |
| Malignant Neoplasms, Carcinogenesis | Epigenetic Alterations | Since DNA methylation-based silencing of hsa-miR-124 occurs in various human cancers, we studied the frequency and functional effects of hsa-miR-124 methylation in cervical carcinogenesis. | 20579385 |
| Carcinogenesis, Mirn124a microRNA, human, cervical cancer | Epigenetic Alterations | DNA methylation-based silencing of hsa-miR-124 is functionally involved in cervical carcinogenesis and may provide a valuable marker for improved detection of cervical cancer and its high-grade precursor lesions. | 20579385 |
| Primary malignant neoplasm | Epigenetic Alterations | A substantial number of microRNAs (miRNAs) is subject to epigenetic silencing in cancer. | 20579385 |
| cervical cancer, Neoplasms | Epigenetic Alterations | Although epigenetic silencing of tumour suppressor genes is an important feature of cervical cancer, little is known about epigenetic silencing of miRNAs. | 20579385 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation. | 20579395 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, the microRNA-200 family was reported to affect cancer biology by regulating epithelial to mesenchymal transition (EMT). | 20579395 |
| Stomach Carcinoma | Epigenetic Alterations | In conclusion, our results suggested that S100A6 plays an important role in the progression of gastric cancer, affecting patient prognosis, and is up-regulated by epigenetic regulation. | 20581057 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumor-related genes by CpG island methylation is an important mechanism for the development of many tumors, including gastric carcinoma. | 20585880 |
| Ulcerative Colitis | Epigenetic Alterations | Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis. | 20586854 |
| Primary malignant neoplasm, Cessation of life | Epigenetic Alterations | It has been recently reported that miRNA have critical functions in key biological processes such as cell proliferation and cell death in various cancer cells. | 20586854 |
| Gastrointestinal inflammation, Ulcerative Colitis | Epigenetic Alterations | Upregulated miRNA may be responsible for the development of intestinal inflammation in UC. | 20586854 |
| Colorectal Cancer Pathway | Epigenetic Alterations | In this prospective study of older women, cigarette smoking was associated with the MSI-high, CIMP-positive, and BRAF mutation-positive colorectal cancer subtypes, which indicates that epigenetic modification may be functionally involved in smoking-related colorectal carcinogenesis. | 20587792 |
| Neoplasms | Epigenetic Alterations | We investigated the likelihood of detecting aberrant DNA methylation of tumor suppressor genes in plasma samples of patients with abnormalities of the lung detected upon computed tomography (CT) scan. | 20592015 |
| Coronary Artery Disease | Epigenetic Alterations | Circulating microRNAs in patients with coronary artery disease. | 20595655 |
| Coronary Artery Disease | Epigenetic Alterations | To address the regulation of circulating microRNAs in patients with stable coronary artery disease. | 20595655 |
| Coronary Artery Disease | Epigenetic Alterations | Interestingly, most of the highly expressed microRNAs that were lower in the blood of patients with coronary artery disease are known to be expressed in endothelial cells (eg, miR-126 and members of the miR-17 approximately 92 cluster). | 20595655 |
| Coronary Artery Disease | Epigenetic Alterations | To prospectively confirm these data, we detected selected microRNAs in plasma of 36 patients with coronary artery disease and 17 healthy volunteers by quantitative PCR. | 20595655 |
| Coronary Artery Disease | Epigenetic Alterations | In contrast, cardiac muscle-enriched microRNAs (miR-133a, miR-208a) tend to be higher in patients with coronary artery disease. | 20595655 |
| Coronary Artery Disease | Epigenetic Alterations | Circulating levels of vascular and inflammation-associated microRNAs are significantly downregulated in patients with coronary artery disease. | 20595655 |
| Hollings Cancer Center | Epigenetic Alterations | Among the 25 HCC samples analyzed, microRNA-183 was significantly up-regulated (twofold to 367-fold) in 17 samples compared with the matching nontumoral liver tissues. | 20602797 |
| Liver carcinoma | Epigenetic Alterations | In recent years, some miRNAs have been reported to be connected closely with the development of human hepatocellular carcinoma. | 20602797 |
| Hollings Cancer Center | Epigenetic Alterations | In our previous studies, a set of miRNAs were revealed to be dysregulated in HCC tissues. | 20602797 |
| Hollings Cancer Center | Epigenetic Alterations | However, the functions of these miRNAs in HCC remain largely undefined. | 20602797 |
| Epilepsy, Epilepsy, Temporal Lobe | Epigenetic Alterations | However, factors that influence MMP-9 gene expression, post-transcriptional modifications, or the balance between activation and inhibition of MMP-9 may play a role in the pathogenesis of TLE and other epileptic syndromes. | 20605480 |
| Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation changes are common somatic alterations in prostate carcinogenesis. | 20606036 |
| Metastasis, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy. | 20609231 |
| Neoplasms, Refractory Cytopenia of Childhood | Epigenetic Alterations | The expression levels of miRNA-155 (p < 0.0001), miRNA-210 (p < 0.0001), miRNA-106a (p < 0.0001) and miRNA-106b (p < 0.0001) were significantly over-expressed in tumor tissue, whereas the expression of miRNA-141 (p < 0.0001) and miRNA-200c (p < 0.0001) were significantly decreased in RCC samples. | 20609231 |
| Neoplasms | Epigenetic Alterations | There were no significant differences between expression levels of miRNA-182 and miRNA-200b in tumor samples and renal parenchyma. | 20609231 |
| Metastasis, Neoplasms, Refractory Cytopenia of Childhood | Epigenetic Alterations | Our data suggest that expression levels of miRNA-106b are significantly lower in tumors of patients who developed metastasis (p = 0.030) and miR-106b is a potential predictive marker of early metastasis after nephrectomy in RCC patients (long-rank p = 0.032). | 20609231 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | For the first time, we have identified a prognostic significance of miRNA-106b, which, after validation on a larger group of patients, maybe useful as a promising biomarker in patients with RCC. | 20609231 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Previous studies have shown altered expression levels of several microRNAs in renal cell carcinoma. | 20609231 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Detection of differentially expressed microRNAs in serum of pancreatic ductal adenocarcinoma patients: miR-196a could be a potential marker for poor prognosis. | 20614181 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have long been established to remain stable in circulation, and dysregulated miRNAs in serum of tumor patients could potentially serve as novel biomarkers. | 20614181 |
| Gastrointestinal Carcinoid Tumor, Neoplasms, Bronchogenic Carcinoma | Epigenetic Alterations | In SCLC tumors, as well as bronchial carcinoids and carcinoids of gastrointestinal origin, recurrent CN alterations were observed in 203 genes, including the RB1 gene and 59 microRNAs of which 51 locate in the DLK1-DIO3 domain. | 20615970 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Our results suggest that genetic, epigenetic, and protein expression pattern alterations of the SDHB gene might play a minor role in the development or progression of gastric cancers. | 20618733 |
| Hepatitis B | Epigenetic Alterations | The hepatitis B virusxprotein (HBx) has been implicated as a potential trigger of the epigenetic deregulation of some genes, but the underlying mechanism remains unknown. | 20620135 |
| Epithelioma | Epigenetic Alterations | Low frequency of epigenetic events in urothelial tumors in young patients. | 20620398 |
| Neoplasms | Epigenetic Alterations | Since many carcinogenic events occur at the epigenetic rather than the genetic level, we analyzed the same tumors for alterations in DNA hypermethylation. | 20620398 |
| Epithelioma | Epigenetic Alterations | Urothelial tumors in patients younger than 19 years have a low rate of epigenetic alteration. | 20620398 |
| Transitional cell carcinoma of bladder, Neoplasms | Epigenetic Alterations | Tumors in patients older than 20 years have epigenetic profiles similar to those of tumors in patients within the typical bladder urothelial cell carcinoma age range. | 20620398 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNAs, which are endogenously expressed regulatory noncoding RNAs, have an altered expression in colorectal cancer. | 20620599 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Chromosome Aberrations | Epigenetic Alterations | This is the first approach to generate an expression profile of 365 microRNAs in myelodysplastic syndromes (MDS) with normal karyotype (n=12) and distinct cytogenetic aberrations (n=12). | 20627384 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | DNA methylation may be important for downregulation of hepaCAM expression in bladder cancer. | 20628239 |
| Neoplasms | Epigenetic Alterations | Alcohol consumption and rectal tumor mutations and epigenetic changes. | 20628283 |
| Neoplasms | Epigenetic Alterations | Epigenetic silencing of Wnt antagonists and expression changes in genes associated with Wnt response pathways occur in early sporadic colorectal tumourigenesis, indicating that tumour cells are more sensitive to Wnt growth factors and respond differently. | 20628379 |
| Esophageal carcinoma | Epigenetic Alterations | MiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma. | 20628822 |
| Ulcerative Colitis-Associated Colorectal Adenocarcinoma, Carcinogenesis | Epigenetic Alterations | As alterations of pro-apoptotic genes might cause instability in the balance of cell-turnover during chronic inflammatory processes, epigenetic silencing of DAPK might be involved in the carcinogenesis of ulcerative colitis-associated carcinoma (UCC). | 20630662 |
| DLEC1 protein, human, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in non-small-cell lung cancer. | 20630829 |
| MYELODYSPLASTIC SYNDROME, Refractory anemia with ringed sideroblasts | Epigenetic Alterations | These results demonstrated, for the first time, the differential ncRNA expression profile between MDS-RARS and healthy individuals, in CD34+ cells and stromal cells, suggesting that ncRNAs may play an important role during the development of myelodysplastic syndromes. | 20633296 |
| Serrated Nodule, Adenomatous hyperplasia | Epigenetic Alterations | DNA methylation varies throughout the normal colorectal mucosa and DNA methylation in normal appearing mucosa is associated with serrated and adenomatous neoplasia elsewhere within the colorectum. | 20635146 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Identifying tumor suppressor genes silenced by promoter CpG methylation uncovers mechanisms of tumorigenesis and identifies new epigenetic biomarkers for early cancer detection. | 20639048 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | We explored its epigenetic alteration in renal cell carcinoma and possible clinicopathological association. | 20639048 |
| Neoplasms | Epigenetic Alterations | The KRAS oncogene and altered levels of the microRNA (miRNA) let-7 are associated with an increased risk of developing solid tumors. | 20647319 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Epigenetic Alterations | MicroRNAs (miRNAs) have been implicated in the epigenetic regulation of key metabolic, inflammatory, and antiangiogenic pathways in type 2 diabetes (DM) and may contribute to common disease complications. | 20651284 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. | 20651284 |
| Diabetes Mellitus | Epigenetic Alterations | We reveal a plasma miRNA signature for DM that includes loss of endothelial miR-126. | 20651284 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Both aberrant localization and epigenetic changes are associated with aberrant expression of connexin 43 in human NSCLC. | 20651379 |
| Glioblastoma Multiforme | Epigenetic Alterations | Epigenetic silencing of the MGMT gene through promoter methylation correlates with improved survival in Glioblastoma Multiforme (GBM) patients receiving concurrent chemoradiotherapy. | 20652362 |
| Neoplasms | Epigenetic Alterations | DNA hypermethylation of promoter CpG islands is known to be a major mechanism for epigenetic inactivation of tumor suppressor genes. | 20652500 |
| Adenocarcinoma of pancreas | Epigenetic Alterations | MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma. | 20652642 |
| Malignant Neoplasms | Epigenetic Alterations | Detection of aberrant microRNA (miR) expression may contribute to diagnosis and prognosis of various cancers. | 20652642 |
| Carcinogenesis | Epigenetic Alterations | To investigate aberrant DNA methylation of CpG islands and subsequent low- or high-level DNA microsatellite instability (MSI) which is assumed to drive colon carcinogenesis. | 20653064 |
| Colorectal Carcinoma, Adenoma | Epigenetic Alterations | DNA of healthy individuals, adenoma (tubular or villous/tubulovillous) patients, and colorectal carcinoma patients who underwent colonoscopy was used for assessing the prevalence of aberrant DNA methylation of human DNA mismatch repair gene mutator L homologue 1 (hMLH1), Cyclin-dependent kinase inhibitor 2A (CDKN2A/p16), and O-6-methylguanine DNA methyltransferase (MGMT), as well as their relation to MSI. | 20653064 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells. | 20655737 |
| Liver carcinoma | Epigenetic Alterations | Recently, some miRNAs have been reported to be connected closely with the development of human hepatocellular carcinoma. | 20655737 |
| Hollings Cancer Center | Epigenetic Alterations | However, the functions of these miRNAs in HCC remain largely undefined. | 20655737 |
| Neoplasms, Malignant Neoplasms, SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Epigenetic Alterations | DNA methylation is one of the major epigenetic changes in human cancers, leading to silencing of tumor suppressor genes, with a pathogenetic role in tumor development and progression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). | 20655775 |
| Malignant Neoplasms, Therapy-related acute myeloid leukemia and myelodysplastic syndrome, Constitutional | Epigenetic Alterations | The significant association with previous malignancy subtypes may underlie a likely susceptibility to methylation of specific targets and a role for constitutional epimutations as predisposing factors for the development of therapy-related myeloid neoplasm. | 20655775 |
| CDISC SDTM Lesion Complexity Terminology | Epigenetic Alterations | Chemotherapy and individual genetic predisposition have a role in t-MDS/AML development, the identification of specific epigenetic modifications may explain complexity and genomic instability of these diseases and give the basis for targeted-therapy. | 20655775 |
| FLT3 Internal Tandem Duplication, Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | FLT3-ITD identifies older CN-AML patients with molecular high risk and is associated with gene- and microRNA-expression signatures that provide biologic insights for novel therapeutic approaches. | 20656931 |
| Adenocarcinoma of pancreas | Epigenetic Alterations | Based upon the clinico-pathologic features of these patients and the role of WRN in experimental models, we propose that its loss-of-function predisposes the development of pancreatic adenocarcinoma through epigenetic silencing or loss-of-heterozygosity of WRN. | 20657174 |
| Inflammatory Breast Carcinoma | Epigenetic Alterations | Integrated miRNA and mRNA expression profiling of the inflammatory breast cancer subtype. | 20664596 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant microRNA (miRNA) expression is presently proposed to correlate with various human cancers and common single-nucleotide polymorphisms (SNP) at miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation. | 20666778 |
| Pituitary Adenoma | Epigenetic Alterations | Down-regulation of Wee1 kinase by a specific subset of microRNA in human sporadic pituitary adenomas. | 20668041 |
| Primary malignant neoplasm | Epigenetic Alterations | Cancer is known to have epigenetic inputs, with events like genomewide hypomethylation and gene-specific hypermethylation of DNA. | 20670142 |
| Abnormal | Epigenetic Alterations | We find that DNA methylation was more prevalent in patients with normal compared to karyotypically abnormal AML for most genes; CEBPa (20% vs 9%), CTNNA1 (14% vs 4%), and ER (41% vs 19%) (p < 0.05 for all comparisons). | 20671427 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia. | 20671427 |
| Schizophrenia, Bipolar Disorder | Epigenetic Alterations | MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. | 20675101 |
| Schizophrenia | Epigenetic Alterations | The number of miRNAs identified is growing rapidly and approximately one-third is expressed in the brain where they have been shown to affect neuronal differentiation, synaptosomal complex localization and synapse plasticity, all functions thought to be disrupted in schizophrenia. | 20675101 |
| Dupuytren Contracture | Epigenetic Alterations | Unique microRNA profile in Dupuytrens contracture supports deregulation of b-catenin pathway. | 20676061 |
| Dupuytren Contracture | Epigenetic Alterations | Identification of unique miRNA expression in Dupuytrens contracture may lead to the development of novel molecular therapy for its treatment. | 20676061 |
| Dupuytren Contracture | Epigenetic Alterations | The miRNAs identified may have a function in the pathogenesis of Dupuytrens contracture by targeting and regulating important pathways. | 20676061 |
| Breast Carcinoma | Epigenetic Alterations | No evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer. | 20680678 |
| Breast Carcinoma | Epigenetic Alterations | Since HIF-1a is frequently expressed in breast carcinomas, we evaluated DNA methylation as a possible mechanism of silencing one or more of the VHL complex genes. | 20680678 |
| Breast Carcinoma, VHL protein, human | Epigenetic Alterations | Epigenetic silencing by promoter DNA methylation for VHL and the complex genes, CUL2, elongin C (TCEB1), elongin B (TCEB2) and RBX1, is unlikely to play a role in HIF-1a upregulation in breast carcinomas. | 20680678 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis. | 20682795 |
| Carcinogenesis | Epigenetic Alterations | Herein, we describe the epigenetic regulation of miR-137 and its contribution to colorectal carcinogenesis. | 20682795 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Global downregulation of microRNAs (miRNA) is a common feature in colorectal cancer (CRC). | 20682795 |
| Breast Carcinoma, Ductal Carcinoma, Neoplasms | Epigenetic Alterations | Promoter hypermethylation of 8 tumor suppressor genes (RASSF1A, APC, HIN1, BRCA1, CYCLIND2, RARbeta, CDH1 and TWIST1) and DNA methylation for three repetitive elements (LINE1, Sat2 and Alu) were analyzed in invasive ductal carcinoma of the breast, paired adjacent normal tissue and WBC from 40 breast cancer patients by the MethyLight assay. | 20682973 |
| Neoplasms | Epigenetic Alterations | DNA methylation for the three repetitive elements was lower in tumor compared to adjacent tissue and WBC DNA. | 20682973 |
| Primary malignant neoplasm | Epigenetic Alterations | Hypermethylation of the CpG islands of gene promoter is one of the earliest and most frequent epigenetic alterations leading to cancer as well as in its development. | 20683150 |
| ovarian neoplasm | Epigenetic Alterations | Whole blood-derived miRNA profiles as potential new tools for ovarian cancer screening. | 20683447 |
| Neoplasms | Epigenetic Alterations | MS-MLPA detects genetic and epigenetic aberrations of 37 tumor suppressor genes (TSG) in a single reaction and might, therefore, avoid the cumbersome single gene analyses. | 20683729 |
| Neoplasms | Epigenetic Alterations | Epigenetic inactivation of tumor suppressor SFRP2 and point mutation in KRAS proto-oncogene in fistula-associated mucinous type anal adenocarcinoma: report of two cases. | 20686305 |
| Anal Mucinous Adenocarcinoma | Epigenetic Alterations | The current results showed that the combined effects of somatic mutations in K-ras and epigenetic alterations in SFRP2 genes may play an active role in the development of mucinous type anal adenocarcinoma. | 20686305 |
| Glioblastoma Multiforme | Epigenetic Alterations | Epigenetic silencing of the O(6)-methylguanine-DNA-methyltransferase (MGMT) gene by promoter methylation is correlated with improved progression-free survival (PFS) and overall survival (OS) in adult patients with newly diagnosed glioblastoma multiforme (GBM) who receive alkylating agents. | 20686820 |
| Neoplasms, Renal Cell Carcinoma Pathway, Hematologic Neoplasms, Prostate Cancer Pathway, Aneuploidy | Epigenetic Alterations | Peripheral blood lymphocytes of patients with hematological malignancies or solid tumors, such as renal cell carcinoma or prostate cancer, display epigenetic aberrations (loss of synchronous replication of allelic counterparts) and genetic changes (aneuploidy) characteristic of the cancerous phenotype. | 20689761 |
| Renal Cell Carcinoma | Epigenetic Alterations | Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas. | 20693965 |
| Refractory Cytopenia of Childhood, Neoplasms | Epigenetic Alterations | Large-scale screening of 3p human chromosome genes/loci in RCC and histologically normal tissues surrounding the tumors using NotI-microarray approach demonstrated that NKIRAS1 gene contained the largest percent of genetic/epigenetic changes in RCC tumor cells. | 20693965 |
| Hypopharyngeal Squamous Cell Carcinoma | Epigenetic Alterations | miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC). | 20700123 |
| Pancreatic carcinoma, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion. | 20703102 |
| Malignant neoplasm of lung, Lymphoma | Epigenetic Alterations | The microRNA-17-92 cluster is an oncogene in human B cell lymphomas and lung cancers. | 20703102 |
| Pancreatic carcinoma | Epigenetic Alterations | Previous microRNA microarray data revealed that miR-17-5p, a member of the miR-17-92 cluster, is upregulated in pancreatic cancer. | 20703102 |
| Hematopoietic Neoplasms, Neoplasms | Epigenetic Alterations | GTPase regulator associated with the focal adhesion kinase (GRAF), a putative tumor suppressor gene, is found inactivated in hematopoietic malignancies by either genetic or epigenetic abnormalities. | 20704716 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic silencing of retinoic acid receptor-beta2 (RARbeta2) and estrogen receptor-alpha (ERalpha) expressions have been revealed to be important in the development of approaches for diagnosis and therapy of breast cancer. | 20711807 |
| Neoplasms | Epigenetic Alterations | Tumour suppressor ING4 is one of ING family genes, which are involved in cell cycle arrest, gene transcription regulation, DNA repair and apoptosis. | 20716169 |
| Prostate Cancer Pathway, Aggressive behavior | Epigenetic Alterations | Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior. | 20717995 |
| Carcinoma of lung, Carcinogenesis | Epigenetic Alterations | Based on the important role of microRNA (miRNA) biosynthesis genes in carcinogenesis, we hypothesized that polymorphisms in the miRNA biosynthesis genes may modulate susceptibility to lung cancer. | 20721975 |
| Hollings Cancer Center | Epigenetic Alterations | Furthermore, we showed that histone modification contributes to leptins gene regulation in HCC. | 20723213 |
| Stomach Carcinoma | Epigenetic Alterations | Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression. | 20726036 |
| Stomach Carcinoma | Epigenetic Alterations | Gastric cancer shows a complex derangement of the miRNA-ome, including Dicer and Drosha. | 20726036 |
| Stomach Carcinoma | Epigenetic Alterations | Twenty miRNAs were up- and two down-regulated in gastric carcinoma compared with non-neoplastic tissue. | 20726036 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Six of these miRNAs separated node-positive from node-negative gastric cancers, ie miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a. | 20726036 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Five miRNAs expressed differentially in node-positive cancers had conserved binding sites for mRNAs differentially expressed in the same set of tumour samples. | 20726036 |
| Colorectal Cancer Pathway | Epigenetic Alterations | microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells. | 20727858 |
| Primary malignant neoplasm | Epigenetic Alterations | Deregulated microRNAs and their roles in cancer development have attracted much attention. | 20727858 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Expression and function of miRNA in postoperative radiotherapy sensitive and resistant patients of non-small cell lung cancer. | 20728239 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Moreover, our results showed miRNA-126 promoted non-small cell lung cancer cells apoptosis induced by irradiation through the PI3K-Akt pathway. | 20728239 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We found 12 differently expressed miRNAs in the radiotherapy sensitive and resistant non-small cell lung cancer samples. | 20728239 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | However, at date the somatic epigenetic events that occur in head and neck squamous cell carcinoma (HNSCC) tumorigenesis are not yet been well defined. | 20729134 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Several SNPs belonging to the pre-miRNA and were identified to be significantly associated with RCC recurrence. | 20732906 |
| Vulva | Epigenetic Alterations | Conclusions are as follows: (i) the epigenetic inactivation of genes is a common event in vulvar SCC and is also present in adjacent lesions, implying a possible precursor role for these alterations; (ii) MGMT and RASSF2A hypermethylation are present exclusively in vulvar SCC and LS associated with SCC, and absent from isolated LS; and (iii) TSP-1 hypermethylation is a bad prognosis factor in vulvar SCC. | 20734389 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. | 20802236 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation profiles can be used to define molecular cancer subtypes that may better inform disease etiology and clinical decision-making. | 20802236 |
| Malignant neoplasm of urinary bladder, Aggressive behavior, Neoplasms | Epigenetic Alterations | Exposures and demographic associated with increased risk of bladder cancer specifically associate with particular subgroups of tumors defined by DNA methylation profiling and these subgroups may define more aggressive disease. | 20802236 |
| Malignant tumor of colon, Neoplasms | Epigenetic Alterations | Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer. | 20802524 |
| Malignant tumor of colon | Epigenetic Alterations | We aim to clarify the epigenetic inactivation, biological function and clinical significance of TBX5 in colon cancer. | 20802524 |
| Neoplastic Syndromes, Hereditary | Epigenetic Alterations | An increasing body of evidence points to a possible role of microRNAs (miRNAs) in hereditary cancer syndromes. | 20810544 |
| Primary malignant neoplasm | Epigenetic Alterations | No allelic variant was detected for hsa-mir-17 and hsa-mir-369, and allelic and genotype frequencies for miR-146a rs2910164 single-nucleotide polymorphism (SNP) were comparable with that of 155 controls from the same population, ruling out a role for genetic variations in these three miRNAs as major determinants in cancer predisposition of BRCA1/BRCA2-negative patients. | 20810544 |
| Carcinogenesis, Carcinoma, Ovarian Epithelial | Epigenetic Alterations | The aim of this study was to analyze promoter hypermethylation profiles of each subtype of ovarian epithelial cancer (OEC), to improve the understanding of the role of epigenetic silencing in carcinogenesis. | 20811671 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic DNA methylations plays an important role in oral carcinogenesis. | 20811686 |
| Malignant neoplasm of mouth | Epigenetic Alterations | WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors. | 20811686 |
| Primary malignant neoplasm | Epigenetic Alterations | This study showed that the methylation is an important epigenetic alteration in oral cancer. | 20811686 |
| Primary malignant neoplasm | Epigenetic Alterations | SFRP-1 was also characterized by a different statistically significant epigenetic behaviour, because of it was demethylated in cancer (p<0.05). | 20811686 |
| Malignant neoplasm of mouth | Epigenetic Alterations | This study suggests that a cause of catenin delocalization in oral cancer could be due to WNT pathway activation, by epigenetic alterations of SFRP, WIF-1 and DKK-3 genes. | 20811686 |
| Ulcerative Colitis | Epigenetic Alterations | We hypothesized that differences in circulating immune cells in CD and UC patients are reflected by altered miRNA expression and that miRNA expression patterns can distinguish CD and UC from normal healthy individuals. | 20812331 |
| Ulcerative Colitis | Epigenetic Alterations | Twelve miRNAs were significantly increased and miRNA-505* was significantly decreased in the blood of active UC patients as compared to healthy controls. | 20812331 |
| Ulcerative Colitis | Epigenetic Alterations | Ten miRNAs were significantly increased and one miRNA was significantly decreased in the blood of active UC patients as compared to active CD patients. | 20812331 |
| Ulcerative Colitis, Crohn Disease | Epigenetic Alterations | Peripheral blood microRNAs distinguish active ulcerative colitis and Crohns disease. | 20812331 |
| Ulcerative Colitis | Epigenetic Alterations | Peripheral blood miRNAs can be used to distinguish active CD and UC from healthy controls. | 20812331 |
| Ulcerative Colitis, Inflammatory Bowel Diseases | Epigenetic Alterations | The data support the evidence that CD and UC are associated with different circulating immune cells types and that the differential expression of peripheral blood miRNAs may form the basis of future diagnostic tests for inflammatory bowel disease. | 20812331 |
| Carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | BMS is an alternative method to detect cancer specific genetic and epigenetic alterations and will be a useful complementary diagnostic tool for lung cancer. | 20813423 |
| Carcinoma of lung | Epigenetic Alterations | Investigation of genetic and epigenetic changes associated with lung cancer has clinical importance for its diagnosis and management. | 20813423 |
| Pathology | Epigenetic Alterations | Serum microRNA characterization identifies miR-885-5p as a potential marker for detecting liver pathologies. | 20815808 |
| Hollings Cancer Center, Liver carcinoma | Epigenetic Alterations | Real-time qPCR (quantitative PCR)-based TaqMan MicroRNA arrays were first employed to profile miRNAs in serum pools from patients with HCC (hepatocellular carcinoma) or LC (liver cirrhosis) and from healthy controls. | 20815808 |
| Pathology | Epigenetic Alterations | In summary, miR-885-5p is significantly elevated in the sera of patients with liver pathologies, and our data suggest that serum miRNAs could serve as novel complementary biomarkers for the detection and assessment of liver pathologies. | 20815808 |
| Malignant neoplasm of breast | Epigenetic Alterations | Biologic profiling of lymph node negative breast cancers by means of microRNA expression. | 20818337 |
| Malignant Neoplasms, Triple-Negative Breast Cancer Finding, Neoplasms | Epigenetic Alterations | Other interesting observations are the presence of several microRNAs (miR532-5p, miR-500, miR362-5p, and miR502-3p) located at Xp11.23 in cancers with a triple-negative signature, and the upregulation of several miR-17 cluster members in estrogen receptor-negative tumors. | 20818337 |
| Neoplasms | Epigenetic Alterations | Genetic and epigenetic alterations identified in this study are correlated with OT molecular groups we have recently reported: a neurogenic group composed of tumors with loss of heterozygosity (LOH) at 1p-19q, IDH1 mutations, and MGMT promoter methylation, showing good prognosis; an intermediate group, presenting TP53 mutations or LOH at 17p, IDH1 mutations, and GSTP1 promoter methylation; and a proliferative group, presenting major genetic alterations (LOH at 10q, EGFR amplification, and CDKN2A/ARF deletion) and poor prognosis. | 20820872 |
| Breast Carcinoma | Epigenetic Alterations | In summary, transcriptional changes induced in breast cancer cells by fibroblasts from positive as well as negative nodes are very much alike in a specific lineage. | 20820980 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Integrated genetic and epigenetic analysis of bladder cancer reveals an additive diagnostic value of FGFR3 mutations and hypermethylation events. | 20824703 |
| Primary malignant neoplasm, Refractory Cytopenia of Childhood | Epigenetic Alterations | In conclusion, our study supports the concept of global histone modification levels as a universal cancer prognosis marker, and provides evidence for the use of histone deacetylases inhibitors as future drugs in the therapy of RCC. | 20825416 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Recent studies have suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. | 20825416 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Global histone acetylation levels: prognostic relevance in patients with renal cell carcinoma. | 20825416 |
| Refractory Cytopenia of Childhood, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Global histone acetylation levels (histone H3 lysine 9 acetylation [H3K9Ac], histone H3 lysine 18 acetylation [H3K18Ac], total histone H3 acetylation [H3Ac] and total histone H4 acetylation [H4Ac]) were determined in patients with renal cell carcinoma (RCC) using immunohistochemistry in a tissue micro array with 193 RCC and 10 oncocytoma specimens. | 20825416 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | The histone acetylation pattern was not different among the diverse histological subtypes of RCC or oncocytoma samples. | 20825416 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic alterations play an important role in carcinogenesis. | 20825416 |
| melanoma, Neoplasms | Epigenetic Alterations | Melanoma cells were harvested from primary, cutaneous MM tumors by laser-capture microdissection, and microRNA expression profiles were obtained by the microarray technique. | 20827223 |
| Aortic Aneurysm, Thoracic, Muscle, Smooth, Vascular, Marfan Syndrome | Epigenetic Alterations | Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms. | 20829218 |
| Aortic Aneurysm, Thoracic | Epigenetic Alterations | Our results demonstrate the heritability, the cell specificity, and the independence with regard to TGF-b1 and genetic backgrounds of the Smad2 dysregulation in human thoracic aneurysms and the involvement of epigenetic mechanisms regulating histone marks in this process. | 20829218 |
| High-Frequency Microsatellite Instability, Stomach Carcinoma, Low-Frequency Microsatellite Instability | Epigenetic Alterations | We demonstrated for the first time that MSI-H can develop from MSI-L or the absence of MSI due to time-dependent accumulation of DNA methylation during progression of early-stage gastric carcinomas. | 20831982 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | DNA methylation in patients with colorectal cancer--correlation with some clinical and morphological features and with local tumour invasion. | 20836393 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are a family of small, non-coding RNA species functioning as negative regulators of multiple target genes including tumour suppressor genes and oncogenes. | 20838434 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. | 20838434 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | To identify potential new amplified oncogenic and/or deleted tumour suppressing miRNAs in lung cancer, we inferred miRNA gene dosage from high dimensional arrayCGH data. | 20838434 |
| Carcinoma of lung | Epigenetic Alterations | Analysis of three independent published lung cancer arrayCGH datasets confirmed that 22 of these miRNA loci showed directionally concordant copy number variation. | 20838434 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | Thus, we show for the first time that putative lung cancer-associated miRNAs can be identified from genome-wide arrayCGH datasets using a bioinformatics mapping approach, and report that miR-218 is a strong candidate tumour suppressing miRNA potentially involved in lung cancer. | 20838434 |
| Rheumatoid Arthritis | Epigenetic Alterations | MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients. | 20840794 |
| Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | We conclude that in older CN-AML patients, low BAALC and ERG expression associates with better outcome and distinct gene and microRNA expression signatures that could aid in identifying new targets and novel therapeutic strategies for older patients. | 20841507 |
| Tumor Hypoxia, Neoplasms | Epigenetic Alterations | Loss of Beclin 1 expression (allelic loss or microRNA regulatory activity, as suggested in the literature) defines poor prognosis presumably by promoting anti-apoptotic pathways, while overexpression of the protein, being linked with tumour hypoxia and acidity, also defines subgroups of tumours with aggressive clinical behaviour. | 20842118 |
| Leukemia, Myelomonocytic, Chronic, Myeloid Leukemia, Chronic | Epigenetic Alterations | Expression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemia. | 20842500 |
| Lesion of breast | Epigenetic Alterations | Previously, we reported that the accuracy of cytological diagnosis of breast lesions could be augmented through the quantitative assessment of DNA methylation of fine-needle aspirate (FNA) washings. | 20842524 |
| Breast Carcinoma | Epigenetic Alterations | Thus, epigenetic biomarkers provide valuable tools for breast cancer patient management. | 20842524 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Functional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer. | 20843712 |
| Malignant neoplasm of urinary bladder, Best Case Imputation Technique | Epigenetic Alterations | Our previous study demonstrated that fascin homolog 1 (FSCN1) might have an oncogenic function in bladder cancer (BC) and that its expression was regulated by specific microRNAs (miRNAs). | 20843712 |
| Neoplasms | Epigenetic Alterations | Our data indicate that LASP1 may have an oncogenic function and that it might be regulated by miR-1, miR-133a, and miR-218, which may function as tumor suppressive miRNAs in BC. | 20843712 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | The main epigenetic modification in glioma is aberrant DNA methylation that is now renowned to be a common hallmark of brain tumors. | 20844987 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Epigenetic inactivation of HOXA5 and MSH2 gene in clear cell renal cell carcinoma. | 20846263 |
| Primary malignant neoplasm | Epigenetic Alterations | The study provides further evidence in support of the notion that epigenetic regulation of let-7a-3 may affect the actions of IGFs in cancer. | 20848182 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Frequent epigenetic inactivation of Myocardin in human nasopharyngeal carcinoma. | 20848417 |
| Nasopharyngeal carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumor suppressor genes plays an important role in nasopharyngeal carcinoma (NPC) tumorigenesis. | 20848417 |
| Chronic inflammatory disorder, Ulcerative Colitis | Epigenetic Alterations | MicroRNAs (miRNAs) are small, noncoding RNAs that act as potent negative regulators of gene expression and are differentially expressed in chronic inflammatory diseases, including UC. | 20848482 |
| Crohns disease of large bowel | Epigenetic Alterations | Identification of microRNAs associated with ileal and colonic Crohns disease. | 20848482 |
| ibudilast, Inflammatory Bowel Diseases | Epigenetic Alterations | The expression differences between ileal CD, colonic CD, and previously identified UC-associated miRNAs support the likelihood that miRNAs influence differing inflammation-related gene expression in each inflammatory bowel disease (IBD) subtype and may form the basis for future diagnostic tests and therapeutic targets for IBD. | 20848482 |
| Ulcerative Colitis | Epigenetic Alterations | Serological and epigenetic markers identify a subset of UC patients with an expression profile of a key TH1 pathogenic cytokine. | 20848535 |
| Carcinogenesis, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Changes in DNA methylation of crucial cancer genes including tumor suppressors can occur early in carcinogenesis, being potentially important early indicators of cancer. | 20849603 |
| Malignant Neoplasms | Epigenetic Alterations | The miR-17-92 gene cluster, a polycistron encoding six microRNAs (miRNA), is frequently overexpressed in human cancers and has been shown to promote several aspects of oncogenic transformation, including evasion of apoptosis. | 20851997 |
| Adenoma of large intestine, Hyperplastic Polyp | Epigenetic Alterations | Furthermore, DNA methylation analysis revealed that the frequency of SHH methylation in CRCs (20.6%) was significantly lower than that in colorectal adenomas (72.4%, p<0.001) and hyperplastic polyps (64.7%, p = 0.002). | 20854074 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation patterns are frequently dysregulated in cancer, although little is known of the mechanisms through which specific gene sets become aberrantly methylated. | 20855866 |
| MICROPHTHALMIA, SYNDROMIC 7, Leukemia, Myelocytic, Acute | Epigenetic Alterations | We find that the promoter DNA methylation signature of EVI1 AML blast cells differs from those of normal CD34(+) bone marrow cells and other AMLs. | 20855866 |
| MICROPHTHALMIA, SYNDROMIC 7 | Epigenetic Alterations | Our data point to a role for EVI1 in directing aberrant promoter DNA methylation patterning in EVI1 AMLs. | 20855866 |
| Multiple Myeloma, Primary malignant neoplasm | Epigenetic Alterations | Epigenetic dysregulation is a hallmark of cancer, including multiple myeloma. | 20862746 |
| Prostate Cancer Pathway | Epigenetic Alterations | [Expressions of 6 microRNAs in prostate cancer]. | 20873592 |
| Malignant Neoplasms | Epigenetic Alterations | Experimental evidence shows that microRNAs play an important role in the initiation and progression of human malignancies. | 20873592 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Then we analyzed the correlation among the expressions of the 6 microRNAs in PCa and their correlation with the Gleason score and clinical stages of PCa. | 20873592 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer. | 20873592 |
| Osteosarcoma | Epigenetic Alterations | microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2. | 20878132 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Circulating miRNAs exist in serum and plasma and they can be used as a potential noninvasive molecular marker for colorectal cancer (CRC) diagnosis. | 20880178 |
| cervical cancer, Federation of Gynecology and Obstetrics | Epigenetic Alterations | Epigenetic therapy and cisplatin chemoradiation in FIGO stage IIIB cervical cancer. | 20882878 |
| Liver carcinoma | Epigenetic Alterations | Efficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers. | 20883676 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation is an epigenetic modification that is profoundly altered in most cancers. | 20885350 |
| Acute myocardial infarction | Epigenetic Alterations | MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction. | 20886220 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Loss of the PTEN tumor suppressor gene occurs frequently in non-small-cell lung carcinoma (NSCLC), although neither genetic alterations nor epigenetic silencing are significant predictors of PTEN protein levels. | 20889565 |
| Prostate Cancer Pathway | Epigenetic Alterations | Suitable reference genes for relative quantification of miRNA expression in prostate cancer. | 20890088 |
| Prostate Cancer Pathway | Epigenetic Alterations | Currently, no validated reference genes for miRNA qPCR in prostate cancer are available. | 20890088 |
| Fibrosis, Liver | Epigenetic Alterations | Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. | 20890893 |
| Hepatocarcinogenesis | Epigenetic Alterations | Recently, miRNAs have been suggested to crucially modulate cellular processes in the liver such as hepatocarcinogenesis. | 20890893 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation epigenotypes in breast cancer molecular subtypes. | 20920229 |
| Breast Carcinoma | Epigenetic Alterations | Our results provide evidence that well defined DNA methylation profiles enables breast cancer subtype prediction and support the utilization of this biomarker for prognostication and therapeutic stratification of patients with breast cancer. | 20920229 |
| Breast Carcinoma | Epigenetic Alterations | Genetic mutations along with epigenetic alterations contribute to gene expression changes occurring in breast cancer. | 20920229 |
| Breast Carcinoma | Epigenetic Alterations | So far, these epigenetic contributions to sporadic breast cancer subtypes have not been well characterized, and there is only a limited understanding of the epigenetic mechanisms affected in those particular breast cancer subtypes. | 20920229 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences. | 20920251 |
| Malignant Neoplasms, Breast Carcinoma | Epigenetic Alterations | Alteration of DNA methylation is an epigenetic change in human cancers, including breast cancer. | 20920981 |
| Myocardium, Cardiovascular Diseases | Epigenetic Alterations | Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease. | 20921333 |
| Pathology | Epigenetic Alterations | Small RNA molecules, called microRNAs, freely circulate in human plasma and correlate with varying pathologies. | 20921333 |
| Viral myocarditis | Epigenetic Alterations | In viral myocarditis, we observed a milder but significant elevation of these microRNAs, 30-fold and 6-fold, respectively. | 20921333 |
| Damage | Epigenetic Alterations | Cardiac damage initiates the detectable release of cardiomyocyte-specific microRNAs-208b and -499 into the circulation. | 20921333 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | We used the techniques of quantitative real-time PCR and DNA methylation-specific PCR combined microdissection to precisely detect MUC4 expression and promoter methylation status in 116 microdissected foci from 57 patients with pancreatic ductal adenocarcinoma. | 20922503 |
| SF3B1 wt Allele | Epigenetic Alterations | Promoter hypermethylation of the NPM1 gene may lead to suppressed gene transcription and hence functional haploinsufficiency, which contributes to the development of MDS. | 20924036 |
| Carcinoma of lung | Epigenetic Alterations | Our approach was to screen for lung cancer by assessing the cheek cells based on emerging genetic/epigenetic data which suggests that the buccal epithelium is altered in lung field carcinogenesis. | 20924114 |
| Glioma, Glioblastoma Multiforme Pathway | Epigenetic Alterations | A study of paired initial and recurrent gliomas demonstrated that methylation profiles were remarkably stable across glioma evolution, even during anaplastic transformation, suggesting that epigenetic alterations occur early during gliomagenesis. | 20926426 |
| Malignant neoplasm of larynx | Epigenetic Alterations | The chondroitin/dermatan sulfate synthesizing and modifying enzymes in laryngeal cancer: expressional and epigenetic studies. | 20929582 |
| Adult Burkitt Lymphoma | Epigenetic Alterations | Alteration of microRNAs regulated by c-Myc in Burkitt lymphoma. | 20930934 |
| cervical cancer | Epigenetic Alterations | The reversing of epigenetic aberrations using the inhibitors of DNA methylation and histone deacetylases may have therapeutic value in cervical cancer. | 20931299 |
| Admitting diagnosis | Epigenetic Alterations | These data support the hypothesis that patterns of miRNA expression in cortical GM may contribute to AD pathogenetically, because the aggregate change in miRNA expression observed early in the disease would be predicted to cause profound changes in gene expression. | 20936480 |
| Primary malignant neoplasm | Epigenetic Alterations | Interaction between the MTHFR C677T polymorphism and alcohol--impact on oral cancer risk and multiple DNA methylation of tumor-related genes. | 20940365 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs), which are endogenously expressed regulatory noncoding RNAs, have an altered expression in tumor tissues. | 20944140 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The evaluation of miRNA expression could yield new information about PCa pathogenesis. | 20944140 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | Inflammatory and microRNA gene expression as prognostic classifier of Barretts-associated esophageal adenocarcinoma. | 20947516 |
| Ovarian Carcinoma, Glioblastoma Multiforme | Epigenetic Alterations | Presence of microRNAS produced by malignant cells has been reported in the blood and saliva of tumor-bearing patients, especially patients diagnosed with glioblastoma or ovarian carcinoma. | 20950422 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Extra-cellular release and blood diffusion of BART viral micro-RNAs produced by EBV-infected nasopharyngeal carcinoma cells. | 20950422 |
| Infection caused by Helicobacter pylori, Stomach Carcinoma | Epigenetic Alterations | MTHFR C677T and Helicobacter pylori infection are believed to play critical roles in the DNA methylation process, an epigenetic feature frequently found in gastric cancer. | 20957490 |
| Communicable Diseases, Neoplasms | Epigenetic Alterations | DNA methylation in CDKN2A associated to the MTHFR 677T carrier is suggested to be a distal tumor characteristic, especially in those 60 years old or older, and it seems to depend on the infection by H. pylori cagA/vacAs1m1 strains. | 20957490 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA expression profiling of exfoliated colonocytes isolated from feces for colorectal cancer screening. | 20959518 |
| Clinical Coordinator | Epigenetic Alterations | Expression analysis of oncogenic microRNA (miRNA) in peripheral blood was recently reported for CRC detection. | 20959518 |
| Clinical Coordinator | Epigenetic Alterations | The exfoliated colonocytes of 197 CRC patients and 119 healthy volunteers were analyzed because of the presence of sufficient miRNA concentration. | 20959518 |
| Clinical Coordinator | Epigenetic Alterations | miRNA was relatively well conserved in exfoliated colonocytes from feces both of CRC patients and healthy volunteers. | 20959518 |
| Clinical Coordinator | Epigenetic Alterations | miRNA expression analysis of the isolated colonocytes may be a useful method for CRC screening. | 20959518 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). | 20960050 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer. | 20960050 |
| ACTH-Producing Pituitary Gland Neoplasm, Pituitary carcinoma | Epigenetic Alterations | MicroRNA expression in ACTH-producing pituitary tumors: up-regulation of microRNA-122 and -493 in pituitary carcinomas. | 20960104 |
| Adenoma, Pituitary carcinoma | Epigenetic Alterations | Both real-time RT-PCR and in situ hybridization showed significant up-regulation of miRNA-122 between pituitary carcinomas and adenomas. | 20960104 |
| Carcinoma, Adenoma | Epigenetic Alterations | MiRNA-493 was also up-regulated in carcinomas compared to ACTH adenomas. | 20960104 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in cell proliferation, differentiation, and apoptosis, and can function as tumor suppressor genes or oncogenes. | 20960104 |
| Carcinoma, Adenoma | Epigenetic Alterations | There were more miRNAs up- (188) or down-regulated (160) between adenomas and normal pituitaries compared to carcinomas and normal pituitaries (92 up- and 91 down-regulated) or between carcinomas and adenomas (46 up- and 52 down-regulated). | 20960104 |
| Pituitary Neoplasms | Epigenetic Alterations | These results provide information about marker miRNAs that may lead to further insights into the regulation of pituitary tumor growth and development. | 20960104 |
| Malignant neoplasm of kidney, Conventional (Clear Cell) Renal Cell Carcinoma, Refractory Cytopenia of Childhood, Neoplasms | Epigenetic Alterations | The commonest histological type of renal cancer, clear cell renal cell carcinoma (cc RCC), is associated with genetic and epigenetic changes in the von Hippel-Lindau (VHL) tumour suppressor. | 20964835 |
| Malignant neoplasm of kidney | Epigenetic Alterations | The VHL-dependent regulation of microRNAs in renal cancer. | 20964835 |
| Neoplasms | Epigenetic Alterations | Differential levels of specific microRNAs (miRNAs) are observed in several tumours when compared to normal tissue. | 20964835 |
| Malignant neoplasm of kidney | Epigenetic Alterations | This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue. | 20964835 |
| Carcinogenesis, ovarian neoplasm | Epigenetic Alterations | Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis. | 20965493 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | The Illumina beads array (Illumina Inc, San Diego, CA) was used to profile DNA methylation in enriched tumor cells that had been isolated from 75 benign and malignant serous tumor tissues and 6 tumor-associated stromal cell cultures. | 20965493 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer. | 20967208 |
| Clinical Coordinator | Epigenetic Alterations | Logistic regression was used to test for association between SNPs in the region of MLH1 and CRC, MSI-H CRC, MLH1 gene expression in CRC, and DNA methylation in CRC. | 20967208 |
| Carcinogenesis, SERPINB3 wt Allele | Epigenetic Alterations | This study showed that IAP expression is an early event in oral carcinogenesis and that epigenetic and genetic pathways are associated with IAP expression in OSCC. | 20967871 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) regulate hundreds of genes central to maintaining a cancer phenotype. | 20975375 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | We measured expression of these miRNAs in formalin-fixed, paraffin-embedded tissue from both tumor and matched normal lung in a set of 46 patients with surgically resected T1 or T2 stage I NSCLC. | 20975375 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | The vast majority of GISTs exhibit activating mutations of KIT or PDGFRA, but epigenetic alteration of GISTs is largely unknown. | 20978145 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Global histone modification patterns as prognostic markers to classify glioma patients. | 20978174 |
| Neoplasms | Epigenetic Alterations | RPA classified the patients into 10 distinct prognostic groups based on WHO grade, histology, and histone modifications: H3K9Ac (<88% or >=88% tumor cells), H3K4diMe (<64% or >=64% tumor cells), H3K18Ac (<74% or >=74% tumor cells), and H4K20triMe (<75% or >=75% tumor cells). | 20978174 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Multiple histone modifications seem to have prognostic relevance in glioma. | 20978174 |
| Neoplasms | Epigenetic Alterations | An altered pattern of epigenetic modifications is central to the development and progression of various tumors. | 20978174 |
| Malignant neoplasm of lung | Epigenetic Alterations | MicroRNAs (miRNA) mediate distinct gene regulatory pathways triggered by epidermal growth factor receptor (EGFR) activation, which occurs commonly in lung cancers with poor prognosis. | 20978205 |
| Carcinoma of lung | Epigenetic Alterations | In this study, we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic "oncomiR" and its role as a key mediator of EGFR signaling in lung cancer cells. | 20978205 |
| Inflammation | Epigenetic Alterations | Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation. | 20980348 |
| Inflammation | Epigenetic Alterations | Chronic inflammation is deeply involved in induction of aberrant DNA methylation, but it is unclear whether any type of persistent inflammation can induce methylation and how induction of cell proliferation is involved. | 20980348 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Using microRNA microarrays, we characterized the microRNA gene expression of 27 patients with acute myeloid leukemia (AML) with normal cytogenetics, focusing on the microRNAs differentially expressed between the M1 and M5 French-American-British (FAB) subtypes. | 20981674 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Expression profiling of cytogenetically normal acute myeloid leukemia identifies microRNAs that target genes involved in monocytic differentiation. | 20981674 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | An accurate delineation of these two AML entities was observed based on the expression of 12 microRNAs. | 20981674 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The expression changes of the candidate microRNAs during monocytic differentiation of AML cell lines treated with Vitamin D and phorbol 12-myristate 13-acetate were examined. | 20981674 |
| Pleural Effusion, Malignant | Epigenetic Alterations | We compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). | 21029414 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating cell-free microRNAs have been identified as potential cancer biomarkers. | 21029414 |
| Pleural Effusion, Malignant, Neoplasms | Epigenetic Alterations | Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions. | 21029414 |
| effusion | Epigenetic Alterations | We measured the expression of 22 miRNAs using qRT-PCR in two samples, which were pooled with 18 malignant and 12 benign effusions, respectively. | 21029414 |
| effusion, Malignant Neoplasms | Epigenetic Alterations | Collectively, our study demonstrated that cell-free miRNAs in the supernatant of effusions may aid in the diagnosis of malignancy and predict chemosensitivity to docetaxel. | 21029414 |
| Endometrial Endometrioid Adenocarcinoma | Epigenetic Alterations | The expression of the miRNA-200 family in endometrial endometrioid carcinoma. | 21035172 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Recent reports suggest that targeting the unique miRNAs highly expressed in several cancers may be a promising approach in the development of new cancer therapeutic tools. | 21035172 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease. | 21037022 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Eight miRNAs were expressed at a significantly lower level in current-smoking patients with COPD compared with never-smokers without airflow limitation. | 21037022 |
| Breast Carcinoma | Epigenetic Alterations | Loss of heterozygosity and DNA methylation affect germline fibroblast growth factor receptor 4 polymorphism to direct allelic selection in breast cancer. | 21037081 |
| Breast Carcinoma | Epigenetic Alterations | These findings support a growth advantage function for FGFR4-R388 and underscore the complex role of DNA methylation and LOH in determining the penetrance of allelic selection in breast cancer progression. | 21037081 |
| Malignant Neoplasms | Epigenetic Alterations | Using a database of 861 colon and rectal cancers, DNA methylation at 16 CpG islands [CACNA1G, CDKN2A (p16/ink4a), CHFR, CRABP1, HIC1, IGF2, IGFBP3, MGMT, MINT-1, MINT-31, MLH1, NEUROG1, p14 (CDKN2A/arf), RUNX3, SOCS1, and WRN] was quantified by real-time PCR. | 21037082 |
| Acute leukemia | Epigenetic Alterations | Expression of IGFBP7 in acute leukemia is regulated by DNA methylation. | 21040219 |
| Acute leukemia | Epigenetic Alterations | In conclusion, aberrant IGFBP7 expression is regulated by DNA methylation in acute leukemia. | 21040219 |
| Metastasis, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Identification and validation of DNA methylation markers to predict lymph node metastasis of esophageal squamous cell carcinomas. | 21042947 |
| Carcinoma of lung | Epigenetic Alterations | SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates. | 21047392 |
| ovarian neoplasm | Epigenetic Alterations | In addition, we have established the clinical relevance of these microRNAs for ovarian cancer patients treatment response and survival. | 21051560 |
| Ovarian Carcinoma | Epigenetic Alterations | Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients. | 21051560 |
| Malignant neoplasm of ovary | Epigenetic Alterations | Distinctive DNA methylation patterns of cell-free plasma DNA in women with malignant ovarian tumors. | 21056906 |
| Liver carcinoma | Epigenetic Alterations | Frequent and distinct aberrations of DNA methylation patterns in fibrolamellar carcinoma of the liver. | 21060828 |
| Liver carcinoma, Hepatocellular Adenoma, Hollings Cancer Center | Epigenetic Alterations | Gene silencing due to aberrant DNA methylation is a frequent event in hepatocellular carcinoma (HCC) and also in hepatocellular adenoma (HCA). | 21060828 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | In contrast to common HCC the APC and CDH1 (E-cadherin) genes were found devoid of any DNA methylation in FLC, whereas the GSTp1 gene showed comparable DNA methylation in tumor and surrounding tissue at a moderate level. | 21060828 |
| Malignant Neoplasms | Epigenetic Alterations | FLCs display frequent and distinct gene-specific hypermethylation in the absence of significant global hypomethylation indicating that these two epigenetic aberrations are induced by different pathways and that full-blown malignancy can develop in the absence of global loss of DNA methylation. | 21060828 |
| Liver carcinoma, Fibrolamellar Hepatocellular Carcinoma | Epigenetic Alterations | However, very little is known about epigenetic defects in fibrolamellar carcinoma (FLC), a rare variant of hepatocellular carcinoma that displays distinct clinical and morphological features. | 21060828 |
| Hodgkin Disease | Epigenetic Alterations | These findings support the notion that epigenetic-interactions between these cytokines may influence pathogenesis of HD modulating the proliferation of regulatory T cells. | 21061265 |
| heterochromatin organization, Chronic Lymphocytic Leukemia | Epigenetic Alterations | Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males. | 21062507 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Increase in acetyl-H3 in resistant female but not male CLL samples as well as a decrease of total cellular level of RelB after an inhibition of histone deacetylase (HDAC) by trichostatin A (TSA), further emphasize the role of epigenetic modifications which could discriminate two CLL subsets. | 21062507 |
| Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | Our observations promote the concept that epigenetic processes are under genetic control and that, other than environment, variation in genes encoding KATs may also determine susceptibility to CHD outcomes and mortality. | 21062767 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer. | 21062931 |
| Pituitary Adenoma | Epigenetic Alterations | MicroRNA profile indicates downregulation of the TGFb pathway in sporadic non-functioning pituitary adenomas. | 21063788 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small, non-coding RNAs of endogenous origin, they have been increasingly shown to have aberrant expression in many tumor types. | 21063914 |
| Colorectal Neoplasms | Epigenetic Alterations | Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. | 21068132 |
| Colorectal Neoplasms | Epigenetic Alterations | Hierarchical epigenetic alterations occur at transition points during colorectal neoplastic progression. | 21068132 |
| Pancreatic Ductal Adenocarcinoma, Pancreatitis | Epigenetic Alterations | The same results were obtained in the expression levels of microRNA-155 in tissue and pancreatic juice between pancreatic ductal adenocarcinoma and chronic pancreatitis (P=0.014 and P=0.021, respectively). | 21068491 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | MicroRNA-21 and microRNA-155 in pancreatic juice have the potential of becoming biomarkers for diagnosing pancreatic ductal adenocarcinoma. | 21068491 |
| malignant disease, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | MicroRNAs are small RNAs regulating various cellular processes and have recently been identified as possible markers of malignant diseases including pancreatic ductal adenocarcinoma. | 21068491 |
| Malignant tumor of colon, Colorectal Carcinoma | Epigenetic Alterations | High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients. | 21069438 |
| Malignant tumor of colon, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-21 (miR-21) is upregulated in several cancer types and has been associated with survival in colon cancer. | 21069438 |
| Malignant tumor of colon | Epigenetic Alterations | We conclude that miR-21 is primarily a stromal microRNA, which when measured by image analysis identifies a subgroup of stage II colon cancer patients with short disease-free survival. | 21069438 |
| Hepatitis B, Chronic | Epigenetic Alterations | Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha. | 21070682 |
| Hepatitis C | Epigenetic Alterations | There have been reports of in-vitro interferon (IFN)-mediated antiviral activity against the hepatitis C virus (HCV) through microRNAs (miRNAs). | 21070682 |
| Virus Diseases, Hepatitis C | Epigenetic Alterations | Given the importance of miRNAs in defending the host against virus infections, it is possible that IFN-induced miRNAs may represent an important determinant of the clinical outcome of IFN therapy in HCV infection. | 21070682 |
| Malignant Neoplasms | Epigenetic Alterations | Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human cancers. | 21073609 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The epigenetic disturbances are recognized as an alternative mechanism contributing to the pathogenesis of acute myeloid leukemia (AML). | 21074269 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Down-regulation of microRNAs 222/221 in acute myelogenous leukemia with deranged core-binding factor subunits. | 21076613 |
| Myeloid neoplasm | Epigenetic Alterations | Epigenetic changes play a role in the pathogenesis of myeloid malignancies, and hypomethylating agents have shown efficacy in these diseases. | 21077739 |
| Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | To our knowledge, we provide the first evidence that the expression of a single microRNA, miR-181a, is associated with clinical outcome of patients with CN-AML and may refine their molecular risk classification. | 21079133 |
| ovarian neoplasm | Epigenetic Alterations | The pathological and clinical significance of aberrant miRNA expression in ovarian tumours has yet to be adequately documented. | 21083603 |
| ovarian neoplasm | Epigenetic Alterations | The miRNA expression profiles of 103 human ovarian tumours were evaluated. | 21083603 |
| Malignant Neoplasms, ovarian neoplasm | Epigenetic Alterations | Via a bead-based miRNA microarray, five aberrant miRNAs were selected which were expressed differentially in malignant serous tumours from borderline and benign ovarian tumours, including miRNA (miR)-519a, miR-18b (up-regulation) and miR-153, miR-511 and miR-485-5p (down-regulation). | 21083603 |
| ovarian neoplasm | Epigenetic Alterations | We conducted quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) in order to confirm that these miRNAs are differentially expressed in different histological subtypes of ovarian tumours, and compared the expression profiles of these miRNAs between different clinical subsets. | 21083603 |
| Malignant neoplasm of ovary | Epigenetic Alterations | A significant correlation was detected between the deregulation of specific types of miRNAs, such as miR-519a, miR-153 and miR-485-5p, and clinical variables as well as histological subtypes in ovarian cancers. | 21083603 |
| ovarian neoplasm | Epigenetic Alterations | An illegitimate microRNA target site within the 3 UTR of MDM4 affects ovarian cancer progression and chemosensitivity. | 21084273 |
| Neoplasms | Epigenetic Alterations | We identified an SNP (SNP34091) in the 3-UTR of MDM4 that creates a putative target site for hsa-miR-191, a microRNA that is highly expressed in normal and tumor tissues. | 21084273 |
| Increase, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma. | 21088996 |
| Pancreatic carcinoma | Epigenetic Alterations | miRNA expression profiles may be used as biomarkers for detecting pancreatic cancer. | 21088996 |
| Malignant Neoplasms, Breast Carcinoma | Epigenetic Alterations | Sporadic breast cancer like many other cancers is proposed to be a manifestation of abnormal genetic and epigenetic changes. | 21092294 |
| Neoplasms | Epigenetic Alterations | Progressive epigenetic alterations in advancing tumors result in aberrant DDR-apoptotic pathway thereby promoting tumor development. | 21092294 |
| Glioblastoma Multiforme | Epigenetic Alterations | Epigenetic silencing of the MGMT gene by promoter methylation blunts repair of O6-methyl guanine and has been shown to be a predictive factor for benefit from alkylating agent therapy in glioblastoma. | 21097691 |
| Carcinoma of lung | Epigenetic Alterations | Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer. | 21102258 |
| Squamous cell carcinoma, Adenocarcinoma, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We tested three key genetic and epigenetic alterations (EGFR, RASSF1A, and BRAF) of this pathway on a series of primary NSCLC (total 111; adenocarcinoma 49, squamous cell carcinoma [SCC] 48, and others 14). | 21102258 |
| Adenocarcinoma | Epigenetic Alterations | Overall, genetic and/or epigenetic alterations of erbB pathway genes were detected in 80% (39/49) of adenocarcinomas.Approximately half of primary adenocarcinoma harbor molecular alterations of the erbB pathway. | 21102258 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic silencing of cancer-related genes by promoter methylation is a frequent event in sporadic colorectal cancer. | 21102416 |
| CpG Island Methylator Phenotype, Colorectal Cancer Pathway | Epigenetic Alterations | The CpG island methylator phenotype (CIMP+), in which discrete genes throughout the genome are simultaneously methylated, and long-range epigenetic silencing, whereby multiple genes within contiguous chromosomal regions are methylated, have been described in subsets of colorectal cancer. | 21102416 |
| CpG Island Methylator Phenotype | Epigenetic Alterations | These findings show that long-range epigenetic silencing across 3p22 occurs in the context of CIMP+ and the BRAF V600E mutation, and only gives rise to microsatellite instability when this process encompasses MLH1. | 21102416 |
| CpG Island Methylator Phenotype | Epigenetic Alterations | Furthermore, the strong relationship between long-range epigenetic silencing of 3p22 and CIMP+ provides further evidence that these two purportedly distinct epigenetic phenotypes represent a single entity with a common aetiology. | 21102416 |
| Neoplasms | Epigenetic Alterations | Low-level methylation of MLH1 and flanking 3p22 genes, as well as the BRAF V600E mutation, were detected in the apparently normal colonic mucosa of a small number of cases whose tumours showed a similar molecular profile, suggesting that these concurring genetic and epigenetic events can occur as a field defect in neoplastic development. | 21102416 |
| Carcinogenesis | Epigenetic Alterations | Altered DNA methylation is often seen in malignant cells, potentially contributing to carcinogenesis by suppressing gene expression. | 21105050 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations in the pattern of DNA and histone modifications play a crucial role in cancer development. | 21106756 |
| SF3B1 wt Allele, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Phosphoinositide-phospholipase C (PI-PLC) b1 is involved in both genetic and epigenetic mechanisms of MDS progression to acute myeloid leukemia. | 21109771 |
| Primary malignant neoplasm | Epigenetic Alterations | With the use of a linear regression model we could adjust for the storage-dependent effect, leading to the identification of 54 differentially expressed miRNAs in tongue cancer, compared to 16 when using standard normalization, including up-regulation of a novel miRNA, miR-424. | 21109926 |
| Breast Cancer Cell, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides that can function as oncogenes or tumor suppressors in human cancer. | 21109942 |
| Malignant Neoplasms, Cell Proliferation, Neoplasms | Epigenetic Alterations | Down-regulation of the miRNA miR-133a in many type of cancers, and a reduction of cell proliferation, migration, and invasion upon over-expression, suggests that miR-133a is a tumor suppressor. | 21109942 |
| Neoplasms | Epigenetic Alterations | The identification of tumor suppressive miRNAs and their target genes could provide new insights into potential mechanism of HNSCC carcinogenesis. | 21109942 |
| Primary malignant neoplasm | Epigenetic Alterations | Promoter-specific expression is regulated by DNA methylation, which is often dysregulated in cancer. | 21109978 |
| ovarian neoplasm | Epigenetic Alterations | The study suggests that DNA methylation regulates IGF-II promoter-specific expression in ovarian cancer and the regulation may play a role in disease progression. | 21109978 |
| Malignant Neoplasms | Epigenetic Alterations | In MNU-induced advanced cancers, DNA methylation at the Tff1 promoter was observed. | 21111741 |
| Carcinogenesis | Epigenetic Alterations | Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing. | 21111741 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations have been correlated with field cancerization in human patients, but evidence from experimental models that specific epigenetic changes can initiate cancer has been lacking. | 21111741 |
| Neoplasms | Epigenetic Alterations | Epigenetic alterations of the trefoil factor 1 (TFF1) tumor suppressor gene were evaluated in vitro and in vivo. | 21111741 |
| Hypergastrinemia (finding), Neoplasms | Epigenetic Alterations | Hypergastrinemia suppressed MNU-dependent tumor initiation and progression in a manner that correlated with gene silencing and epigenetic alterations of Tff1. | 21111741 |
| Stomach Carcinoma | Epigenetic Alterations | In gastric cancer cells, gastrin stimulation partially reversed the epigenetic silencing in the TFF1 promoter. | 21111741 |
| Stomach Carcinoma | Epigenetic Alterations | Initiation of antral gastric cancer is associated with progressive epigenetic silencing of TFF1, which can be suppressed by the hormone gastrin. | 21111741 |
| Hollings Cancer Center | Epigenetic Alterations | Subsequent differential microRNA expression profiling of CD133(+) and CD133- cells from human HCC clinical specimens and cell lines identified an overexpression of miR-130b in CD133(+) TICs. | 21112564 |
| Aneuploidy, Neoplasms | Epigenetic Alterations | Among paired samples, the highest frequencies of DNA methylation were found in tumours with aneuploidy. | 21115918 |
| Neoplasms | Epigenetic Alterations | The altered miRNA expressions were reproducibly confirmed in the tumor tissues. | 21116241 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | A logistic regression model with the best prediction was defined on the basis of the four genes (miRNA-21, -126, -210, and 486-5p), yielding 86.22% sensitivity and 96.55% specificity in distinguishing NSCLC patients from the healthy controls. | 21116241 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Plasma microRNAs as potential biomarkers for non-small-cell lung cancer. | 21116241 |
| Primary Neoplasm, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Using microarray platforms, we previously identified 12 microRNAs (miRNAs) the aberrant expressions of which in primary lung tumors are associated with early-stage NSCLC. | 21116241 |
| Lung Neoplasms, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We initially validated expressions of the miRNAs in paired lung tumor tissues and plasma specimens from 28 stage I NSCLC patients by real-time quantitative reverse transcription PCR, and then evaluated diagnostic value of the plasma miRNAs in a cohort of 58 NSCLC patients and 29 healthy individuals. | 21116241 |
| Neoplasms | Epigenetic Alterations | Of the 12 miRNAs, five displayed significant concordance of the expression levels in plasma and the corresponding tumor tissues (all r>0.850, all P<0.05). | 21116241 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Furthermore, the panel of miRNAs produced 73.33% sensitivity and 96.55% specificity in identifying stage I NSCLC patients. | 21116241 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Altered expressions of the miRNAs in plasma would provide potential blood-based biomarkers for NSCLC. | 21116241 |
| Neoplasms | Epigenetic Alterations | These results identify a role for Sp100 as a tumor suppressor in addition to its role in maintaining ND10/PML bodies and in the epigenetic regulation of gene expression. | 21118961 |
| ovarian neoplasm | Epigenetic Alterations | Taken together, miRNA-related genetic polymorphisms may impact ovarian cancer predisposition and clinical outcome both individually and jointly. | 21118967 |
| Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | After selecting 15 CpG island loci showing breast cancer-specific DNA methylation, another set of normal breast tissue (n = 10), ADH/FEA (n = 30), DCIS (n = 35), and IDC (n = 30) of the breast were analyzed for these loci. | 21120523 |
| Hepatitis C | Epigenetic Alterations | Autoantibodies to a miRNA-binding protein Argonaute2 (Su antigen) in patients with hepatitis C virus infection. | 21122261 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. | 21123457 |
| palladium | Epigenetic Alterations | Our findings suggest that a novel epigenetic regulatory mechanism controlling SNCA expression influences PD pathogenesis. | 21124796 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Neoplasms | Epigenetic Alterations | Previous research on the epigenetics of myelodysplastic syndromes (MDS) mainly focused on the inactivation of tumor suppressor genes as a result of DNA methylation. | 21125401 |
| SF3B1 wt Allele | Epigenetic Alterations | Recent studies have revealed that DNA methylation and histone modification may be controlled by Polycomb-group (PcG) proteins, which may give new clues toward understanding the epigenetic mechanism of MDS. | 21125401 |
| SF3B1 wt Allele | Epigenetic Alterations | The MDS patients with DNA methylation had higher EZH2 expression than those without DNA methylation. | 21125401 |
| SF3B1 wt Allele | Epigenetic Alterations | However, the basic molecular pathogenesis of epigenetics in MDS remains poorly understood. | 21125401 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring. | 21125401 |
| SF3B1 wt Allele | Epigenetic Alterations | The products of these genes might participate in epigenetic regulation of MDS. | 21125401 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Aberrant microRNA expression in Chinese patients with chronic lymphocytic leukemia. | 21130495 |
| Malignant Neoplasms, Childhood Leukemia | Epigenetic Alterations | Many reports have indicated that miRNAs play a critical role in malignancies, and regulations in the progression of leukemia. | 21130495 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | However, the miRNAs expression level in Chinese patients with chronic lymphocytic leukemia (CLL), and its prognostic value remain elusive. | 21130495 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | In addition, an inverse correlation was observed in the CLL samples we examined between miRNAs (miR-16-1, miR-181a, miR-181b) and BCL-2 level; furthermore, an inverse correlation was also observed between miRNAs (miR-16-1, miR-181a, miR-181b) and TCL-1, which suggest that these miRNAs may implicate in negatively regulating target mRNA at transcriptional level. | 21130495 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | These different miRNAs may play an important role in the pathogenesis of CLL and might be applied for the assessment of prognosis in patients with CLL. | 21130495 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Differential miRNA expression profiles in bladder urothelial carcinomas. | 21133599 |
| Neoplasms | Epigenetic Alterations | Creation of lists of miRNAs differentially expressed between this tumor type and normal tissue might help identify new diagnostic and prognostic markers. | 21133599 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | These findings suggest that these miRNAs may be involved in bladder urothelial carcinoma pathogenesis and have potential as biomarkers. | 21133599 |
| Stomach Carcinoma | Epigenetic Alterations | Results of our study imply that there is either germline mutation or an epigenetic inactivation of another MMR gene, which causes MSI phenotype in the referred gastric cancer cases. | 21136174 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Deregulation of Aiolos expression in chronic lymphocytic leukemia is associated with epigenetic modifications. | 21139082 |
| Gain, Chronic Lymphocytic Leukemia | Epigenetic Alterations | These epigenetic modifications should allow its upstream effectors, such as nuclear factor-kB, constitutively activated in CLL, to gain access to promoter, resulting up-regulation of Aiolos. | 21139082 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Our results strongly suggest that Aiolos deregulation by epigenetic modifications may be a hallmark of CLL. | 21139082 |
| Carcinogenesis | Epigenetic Alterations | MGMT promoter hypermethylation and epigenetic silencing often occur as early events in carcinogenesis. | 21140203 |
| Lynch Syndrome | Epigenetic Alterations | We previously showed that constitutional 3 end deletions of EPCAM can cause Lynch syndrome through epigenetic silencing of MSH2 in EPCAM-expressing tissues, resulting in tissue-specific MSH2 deficiency. | 21145788 |
| Hepatocarcinogenesis, Hollings Cancer Center | Epigenetic Alterations | A general stepwise increase in methylating events is seen during HBV-related multistep hepatocarcinogenesis, and epigenetic changes may occur predominantly in the earlier stages of HCC development. | 21145824 |
| Hepatocarcinogenesis, Premalignant | Epigenetic Alterations | However, miRNA deregulation in the pre-malignant lesions and expression changes during multistep hepatocarcinogenesis remain elusive. | 21145831 |
| Hepatocarcinogenesis | Epigenetic Alterations | Our results showed that miRNA deregulation was an early event and accumulated throughout the various steps of HBV-associated hepatocarcinogenesis. | 21145831 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | Our findings also suggest that miR-145 is a candidate tumor suppressive miRNA and may play an important role in HCC development. | 21145831 |
| Liver carcinoma | Epigenetic Alterations | Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. | 21146512 |
| Hollings Cancer Center | Epigenetic Alterations | Herein, we sought to establish DNA methylation patterns in HCC and corresponding cirrhotic tissues and to identify DNA methylation changes associated with major risk factors. | 21146512 |
| Hollings Cancer Center | Epigenetic Alterations | We have established assays for quantitative analysis of DNA methylation levels in a panel of seven cancer-associated genes and repetitive elements, and combined these assays with a series of HCC tumors, associated with major risk factors, collected from two different geographical areas. | 21146512 |
| Hollings Cancer Center | Epigenetic Alterations | This study identifies aberrant DNA methylation of specific cellular genes in HCC and the major risk factors associated with these changes, providing information that could be exploited for biomarker discovery in clinics and molecular epidemiology. | 21146512 |
| Treatment/Psychosocial Effects | Epigenetic Alterations | Epigenetic patterns associated with the immune dysregulation that accompanies psychosocial distress. | 21146603 |
| Malignant neoplasm of larynx, Malignant Head and Neck Neoplasm | Epigenetic Alterations | While recent observations indicate the occurrence of an epigenetic field defect in head and neck cancer patients, a detailed exploration of the characteristic changes in the DNA methylation profile in laryngeal cancer patients was lacking. | 21147548 |
| Laryngeal neoplasm | Epigenetic Alterations | Our findings indicate the high prevalence of epigenetic abnormalities in laryngeal tumors. | 21147548 |
| Initiation | Epigenetic Alterations | Recent evidence indicates that small noncoding RNA molecules, known as microRNAs (miRNAs), are involved in cancer initiation and progression. | 21149617 |
| Kidney Diseases, Diabetes Mellitus, Kidney Failure, Chronic | Epigenetic Alterations | DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy. | 21150313 |
| Chronic kidney disease stage 5, Kidney Failure, Chronic, Kidney Diseases, Diabetes Mellitus, Chronic Kidney Diseases | Epigenetic Alterations | We identified potential epigenetic biomarkers for chronic kidney disease progression by comparing site-specific DNA methylation levels in more than 14,000 genes between African American and Hispanic diabetes patients with end stage renal disease (ESRD) and diabetes patients without nephropathy. | 21150313 |
| Kidney Diseases | Epigenetic Alterations | The fact that these nephropathy and/or dialysis-associated differences between patients were identified in DNA extracted from saliva offers proof-of-principle that inter-individual epigenetic differences may prove useful as predictive biomarkers of disease susceptibility. | 21150313 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome. | 21150891 |
| SF3B1 wt Allele, Refractory anemia with excess blasts I, Refractory anemia with excess blasts II | Epigenetic Alterations | Differences in miRNA expression of MDS subtypes showed a distinction between early and advanced MDS; an apparent dissimilarity was observed between RAEB-1 and RAEB-2 subtypes. | 21150891 |
| SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | However, limited information is available regarding the role of miRNAs in myelodysplastic syndrome (MDS). | 21150891 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic silencing of peroxisome proliferator-activated receptor g is a biomarker for colorectal cancer progression and adverse patients outcome. | 21151932 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | Our findings provide a novel mechanistic insight into epigenetic silencing of PPARG in CRC that may be relevant as a prognostic marker of tumor progression. | 21151932 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant promoter hypermethylation (methylation) is an epigenetic change that silences the expression of crucial genes, thus inactivating the apoptotic pathway in various cancers. | 21152877 |
| Adenoma, Sessile Serrated Adenoma/Polyp | Epigenetic Alterations | Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract. | 21154739 |
| Glioblastoma Multiforme | Epigenetic Alterations | DNA methylation in glioblastoma: impact on gene expression and clinical outcome. | 21156036 |
| Glioblastoma Multiforme | Epigenetic Alterations | Changes in promoter DNA methylation pattern of genes involved in key biological pathways have been reported in glioblastoma. | 21156036 |
| Glioblastoma Multiforme | Epigenetic Alterations | Genome-wide assessments of DNA methylation levels are now required to decipher the epigenetic events involved in the aggressive phenotype of glioblastoma, and to guide new treatment strategies. | 21156036 |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Epigenetic Alterations | Epigenetic regulation of PAX5 expression in acute T-cell lymphoblastic leukemia. | 21156323 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. | 21156726 |
| ovarian neoplasm | Epigenetic Alterations | Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. | 21156726 |
| Soft Tissue Injuries | Epigenetic Alterations | Recently, plasma miRNAs have been reported to be sensitive and specific biomarkers of various tissue injuries and pathological conditions. | 21157109 |
| Malignant Neoplasms, DICER1 protein, human | Epigenetic Alterations | Dicer and Drosha are key enzymes in the miRNA-processing pathway which is altered in many human cancers. | 21160068 |
| Primary malignant neoplasm | Epigenetic Alterations | Polycomb Group (PcG) proteins are epigenetic silencers involved in maintaining cellular identity, and their deregulation can result in cancer. | 21162745 |
| Klatskin Tumor | Epigenetic Alterations | Taqman microRNA assay shows that down-regulation of miR-373 is closely associated with poor cell differentiation, advanced clinical stage and shorter overall and disease-free survival in hilar cholangiocarcinomas. | 21165562 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant expression of miRNAs is associated with particular cancers showing tissue- and clinical-feature-specificity patterns. | 21165562 |
| Ulcerative Colitis | Epigenetic Alterations | MiR-96 and miR-183 were differentially upregulated microRNA in our previous microRNA screening for UC. | 21166959 |
| Squamous cell carcinoma, SERPINB3 wt Allele, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are epigenetic regulators of gene expression, and their deregulation plays an important role in human cancer, including oral squamous cell carcinoma (OSCC). | 21167132 |
| Mammary Neoplasms | Epigenetic Alterations | Alcohol consumption in relation to aberrant DNA methylation in breast tumors. | 21168302 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Alcohol may impact breast malignancies or tumor progression by altering DNA methylation. | 21168302 |
| Breast Carcinoma | Epigenetic Alterations | We found alcohol consumption was associated with DNA methylation in postmenopausal breast tumors, suggesting that the association of alcohol and breast cancer may be related, at least in part, to altered methylation, and may differ by drinking pattern. | 21168302 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | To gain insight into the role of epigenetic aberration of cell-cycle regulator genes in oesophagus squamous cell carcinoma (ESCC), the authors determined the hypermethylation profile in ESCC. | 21169275 |
| Fragile X Syndrome | Epigenetic Alterations | In patient-derived lymphoblasts and fibroblasts, we determined by chromatin immunoprecipitation that there is increased acetylation of histones at the FMR1 locus in pre-mutation carriers compared to control or FXS derived cell lines. | 21170301 |
| Neoplasms | Epigenetic Alterations | We performed loss-of-function and gain-of-function experiments regarding cell proliferation, cell cycle, apoptosis, in vivo tumor formation and luciferase reporter assays, using siRNAs against PLK1 and miRNA. | 21170987 |
| Bladder Neoplasm | Epigenetic Alterations | A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression. | 21173382 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic silencing can extend to whole chromosomal regions in cancer. | 21173382 |
| Bladder Neoplasm, Primary malignant neoplasm | Epigenetic Alterations | We searched for chromosomal regions affected by epigenetic silencing in cancer by using Affymetrix microarrays and real-time quantitative polymerase chain reaction to analyze RNA from 57 bladder tumors compared with normal urothelium. | 21173382 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Clustering was used to distinguish tumors with multiple regional epigenetic silencing (MRES) from those without and to analyze the association of this phenotype with histopathologic and molecular types of bladder cancer. | 21173382 |
| Bladder Neoplasm | Epigenetic Alterations | Cell lines derived from aggressive bladder tumors presented epigenetic silencing of the same regions. | 21173382 |
| Malignant neoplasm of urinary bladder, Carcinoma | Epigenetic Alterations | We have identified an MRES phenotype characterized by the concomitant epigenetic silencing of several chromosomal regions, which, in bladder cancer, is specifically associated with the carcinoma in situ gene expression signature. | 21173382 |
| Secondary malignant neoplasm of liver, Colorectal Carcinoma | Epigenetic Alterations | MicroRNA expression profiles in human colorectal cancers with liver metastases. | 21174058 |
| Malignant Neoplasms, Disease | Epigenetic Alterations | MicroRNAs (miRNAs) are shown to be involved in various human diseases including cancers through negative regulation of target gene expression at the post-transcriptional level. | 21174058 |
| Secondary malignant neoplasm of liver, Colorectal Carcinoma | Epigenetic Alterations | Of these, 4 miRNAs including miR-150*, miR-125b-2*, miR-1179 and miR-139-3p were up-regulated in colorectal cancers with liver metastasis while the others were down-regulated. | 21174058 |
| Secondary malignant neoplasm of liver, Carcinogenesis, Colorectal Carcinoma | Epigenetic Alterations | Our results indicated that miRNAs are not only involved in carcinogenesis of colorectum, but may also participate in the progression such as with liver metastases in human colorectal cancers. | 21174058 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer (CRC) is caused by an accumulation of genetic alterations and epigenetic alterations. | 21174064 |
| Clinical Coordinator | Epigenetic Alterations | The combination of genetic and epigenetic alterations may be a good marker for the prognosis of CRC patients. | 21174064 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | Copy number alterations in urothelial carcinomas: their clinicopathological significance and correlation with DNA methylation alterations. | 21177765 |
| Carcinogenesis | Epigenetic Alterations | Both genetic and epigenetic events appear to accumulate during urothelial carcinogenesis, reflecting the clinicopathological diversity of UCs. | 21177765 |
| Disease | Epigenetic Alterations | Changes in DNA methylation may represent an intermediate step between the environment and human diseases. | 21178401 |
| Senile angioma | Epigenetic Alterations | Investigation of senile hemangioma and the regulatory mechanisms of angiogenesis by miRNA in the aged skin may lead to new treatments using miRNA by the transfection into senile hemangioma. | 21179471 |
| Primary malignant neoplasm | Epigenetic Alterations | Global genomic hypomethylation is a common epigenetic event in cancer that mostly results from hypomethylation of repetitive DNA elements. | 21188491 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Aberrant expression of microRNA (miRNA) is commonly associated with cancer and loss of miR-124a has previously been implicated to function as a tumour suppressor. | 21196113 |
| Ductal Breast Carcinoma | Epigenetic Alterations | Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification. | 21197409 |
| Hepatitis C | Epigenetic Alterations | Liver-specific microRNA-122 (miR-122) has been shown to facilitate the replication of hepatitis C virus (HCV) in human hepatoma cells in vitro. | 21199296 |
| Neoplasms | Epigenetic Alterations | Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. | 21199797 |
| Neoplasms | Epigenetic Alterations | Our results indicate that tumor identity is achieved mainly by variation in the expression levels of a common set of miRNAs rather than by tissue-specific expression. | 21199797 |
| Breast Carcinoma | Epigenetic Alterations | Ten percent of the new miRNAs are located in regions with high-level genomic amplifications in breast cancer. | 21199797 |
| Breast Carcinoma | Epigenetic Alterations | In summary, our work substantially expands the number of known miRNAs and highlights the complexity of small RNA expression in breast cancer. | 21199797 |
| Primary central nervous system lymphoma | Epigenetic Alterations | With a candidate approach and miRNA quantification by reverse transcription polymerase chain reaction, miRNAs with significant levels in the CSF of patients with PCNSL were identified. | 21200023 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are regulatory RNA molecules that are deregulated in many disease types, including cancer. | 21200023 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, miRNAs have shown promise as markers for cancer diagnosis. | 21200023 |
| Primary central nervous system lymphoma | Epigenetic Alterations | In conclusion, CSF miRNAs are potentially useful tools as novel noninvasive biomarker for the diagnosis of PCNSL. | 21200023 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetics, particularly DNA methylation, has recently been elucidated as important in gastric cancer (GC) initiation and progression. | 21203466 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. | 21205967 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | A microRNA/TP53 feedback circuitry is associated with CLL pathogenesis and outcome. | 21205967 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | This mechanism provides a novel pathogenetic model for the association of 13q deletions with the indolent form of CLL that involves microRNAs, TP53, and ZAP70. | 21205967 |
| Fragile X Syndrome | Epigenetic Alterations | Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056. | 21209411 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Polymorphic variants in genes involved in one-carbon metabolism, in particular of dietary folate, may modulate the risk for colorectal cancer through aberrant DNA-methylation and altered nucleotide synthesis and repair. | 21211571 |
| SF3B1 wt Allele | Epigenetic Alterations | These findings suggest that suppression of DAPK1 expression by DNA methylation may play a substantial role in the development of MDS. | 21212658 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | MiRNA profile in esophageal squamous cell carcinoma: downregulation of miR-143 and miR-145. | 21218087 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The expression profile of miRNA in ESCC tissues was analyzed by miRNA microarray. | 21218087 |
| Esophageal carcinoma | Epigenetic Alterations | The mobility effect was estimated by wound-healing using esophageal carcinoma cells transfected with miRNA expression plasmids. | 21218087 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | These findings suggest that the deregulation of miRNAs plays an important role in the progression of ESCC. | 21218087 |
| Neoplasms | Epigenetic Alterations | In recent years, microRNAs (miRNAs) have been found to play an essential role in tumor development. | 21219656 |
| Neoplasms | Epigenetic Alterations | MiR-155 is one of the miRNAs most consistently involved in various neoplastic diseases. | 21219656 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. | 21220473 |
| Neoplasms | Epigenetic Alterations | MicroRNA 125a-5p (miR-125a-5p) has been reported to be a tumor suppressor in malignancies of the breast, ovary, lung, and central nervous system. | 21220473 |
| melanoma, Primary malignant neoplasm | Epigenetic Alterations | We previously reported that the miR-34a gene is subject to epigenetic inactivation by CpG methylation of its promoter region in primary prostate cancer and melanomas, and in 110 different cancer cell lines of diverse origin. | 21225432 |
| Breast Carcinoma | Epigenetic Alterations | Further studies on sources of "remaining" heterogeneity of population with breast cancer (such as genetic/epigenetic characteristics) are necessary. | 21225455 |
| Carcinogenesis, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Changes in DNA methylation of tumor suppressors can occur early in carcinogenesis and are potentially important early indicators of cancer. | 21227392 |
| Conventional (Clear Cell) Renal Cell Carcinoma, Metastasis | Epigenetic Alterations | Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma. | 21229250 |
| Metastasis | Epigenetic Alterations | We aimed at identifying specific miRNA expression patterns that are associated with metastasis and prognosis in ccRCC patients. | 21229250 |
| Metastasis, Neoplasms, Neoplasm Metastasis | Epigenetic Alterations | MiRNA of 30 human ccRCC including ten non-metastatic tumours, four tumours with metastasis after 3 years or later and four tumours with primary metastasis was isolated. | 21229250 |
| Aggressive behavior, Neoplasms | Epigenetic Alterations | Furthermore, we identified a group of 12 miRNAs, such as let-7 family, miR-30c, miR-26a, which are decreased in highly aggressive primary metastatic tumours. | 21229250 |
| Metastasis | Epigenetic Alterations | Our findings suggest that specific miRNAs are involved in metastasis and have an impact on the progression of the ccRCC. | 21229250 |
| Aggressive behavior, Metastasis | Epigenetic Alterations | Furthermore, we identified specific miRNAs characterising very aggressive tumours with early metastasis. | 21229250 |
| Primary Neoplasm, Metastasis | Epigenetic Alterations | Thus, it seems possible to use miRNAs for prediction of progression to distant metastasis and prognosis analysing the primary tumour. | 21229250 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The hallmark of cancer epigenetics is aberrant DNA methylation consisting of global hypomethylation and regional hypermethylation of tumor suppressor genes (TSGs) by DNA methyltransferases (DNMTs). | 21229291 |
| Primary malignant neoplasm | Epigenetic Alterations | The role of epigenetics and significance of aberrant gene regulation in etiology of cancer is a well-established phenomenon. | 21229291 |
| Glioma | Epigenetic Alterations | Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas. | 21229291 |
| Glioma | Epigenetic Alterations | Interestingly, little is known about variation in the methylation status of epigenetic regulators themselves in gliomas. | 21229291 |
| Malignant neoplasm of lung, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation of some tumor suppressor genes in lung cancers from workers with chromate exposure. | 21229606 |
| Primary malignant neoplasm | Epigenetic Alterations | Numerous studies have shown that aberrant microRNA (miRNA) expression is associated with the development and progression of various types of human cancer and serum miRNAs are potential biomarkers. | 21229610 |
| Liver carcinoma, Hepatitis, Chronic | Epigenetic Alterations | Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. | 21229610 |
| Hepatitis, Chronic | Epigenetic Alterations | However, these elevated serum miRNAs were also detected in patients with chronic hepatitis (P = 2.05 x 10-12, P = 4.52 x 10-16, and P = 1.65 x 10-11, respectively). | 21229610 |
| Squamous cell carcinoma | Epigenetic Alterations | As epithelial-mesenchymal transition is the postulated pathogenetic mechanism in spindle cell carcinoma, we analyzed the expression of these microRNAs in spindle cell carcinoma of the head and neck in comparison to conventional squamous cell carcinoma of similar location and stage. | 21237487 |
| Carcinoma, Spindle-Cell | Epigenetic Alterations | These microRNAs act on transcription repressors that were also up-regulated in our cases of spindle cell carcinoma, both on mRNA and on protein levels. | 21237487 |
| cervical cancer, Neoplasms | Epigenetic Alterations | Epigenetic regulation of the potential tumor suppressor gene, hLHX6.1, in human cervical cancer. | 21240459 |
| cervical cancer | Epigenetic Alterations | This epigenetic alteration in the hLHX6.1 promoter begins at a relatively early stage, suggesting its potential as a biomarker for the early diagnosis and prevention of cervical cancer. | 21240459 |
| Lung Diseases, Interstitial | Epigenetic Alterations | Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes. | 21241464 |
| Gastrointestinal Stromal Tumors, Metastasis | Epigenetic Alterations | Although the main cause of gastrointestinal stromal tumor (GIST) is gain-of-function mutations in the c-kit gene in the interstitial cells of Cajal, concomitant genetic or epigenetic changes other than c-kit appear to occur in the development of metastasis. | 21244575 |
| Oral Cavity Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA expression profiling of oral carcinoma identifies new markers of tumor progression. | 21244772 |
| Neoplasms | Epigenetic Alterations | Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. | 21244772 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Since miRNAs have been shown to be abnormally expressed in different tumours their importance as potential cancer prognostic indicators is increasing. | 21244772 |
| Carcinoma of lung | Epigenetic Alterations | Epigenetic mechanisms for silencing glutathione S-transferase m2 expression by hypermethylated specificity protein 1 binding in lung cancer. | 21246532 |
| Malignant Neoplasms | Epigenetic Alterations | We hypothesized that p53 mutations may lead to different transcriptional changes and carry different prognostic value in these two different types of cancers. | 21248301 |
| Behavior, Carcinogenesis | Epigenetic Alterations | Abnormal miRNA expression has emerged as crucial factors in carcinogenesis and is important in the comprehension of prostate cancer behavior. | 21255804 |
| Prostate Cancer Pathway | Epigenetic Alterations | We determined the correlation of miRNA expression profiles with prostate cancer progression. | 21255804 |
| Breast Cancer Cell | Epigenetic Alterations | Aberrant DNA methylation is a common phenomenon in human cancer. | 21255913 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Thus, the results indicated that methylated alteration of multiple genes plays an important role in NSCLC pathogenesis and a panel of candidate epigenetic biomarkers for NSCLC detection in the Chinese population was identified. | 21255913 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer. | 21258252 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA profiling was performed on total RNA extracted from serum obtained from 22 individuals (11 controls and 11 patients with early-stage NSCLC). | 21258252 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These miRNAs may serve as biomarkers for NSCLC early detection. | 21258252 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Receiver operating characteristic curves plotting these two miRNAs were able to discriminate early-stage NSCLC samples from controls with 82% and 77% of sensitivity and specificity, respectively, in the discovery cohort and with 73% and 71% of sensitivity and specificity, respectively, in the validation cohort. | 21258252 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Serum miRNAs are differentially expressed between patients with early-stage NSCLC and controls. | 21258252 |
| Carcinogenesis | Epigenetic Alterations | Here, we first evaluated SMARCA5 expression and promoter DNA methylation in gastric carcinogenesis. | 21261476 |
| melanoma | Epigenetic Alterations | Immunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi. | 21262599 |
| Malignant Neoplasms, melanoma | Epigenetic Alterations | Although a variety of malignancies have been attributed to perturbations in the miRNA machinery, there has been little research conducted on the role of miRNAs in cutaneous malignant melanoma and its premalignant lesions. | 21262599 |
| DICER1 protein, human | Epigenetic Alterations | Dicer is an essential cytosolic enzyme necessary for processing pre-microRNAs into mature microRNAs (miRNAs). | 21262599 |
| Neoplasms | Epigenetic Alterations | p14(ARF), p15(INK4b), and p16(INK4a) are tumor suppressor genes that are located closely at 9p21 and are often coinactivated by genetic or epigenetic alterations. | 21262917 |
| Malignant tumor of colon, Colonic Neoplasms | Epigenetic Alterations | We determined that DNA methylation of the YPEL3 promoter CpG island does not play a role in YPEL3 regulation in human colon tumors or colon cancer cells lines, consistent with the inability of 5-azadeoxycytidine treatment to induce YPEL3 expression in colon cancer cell lines. | 21267786 |
| Malignant tumor of colon | Epigenetic Alterations | In contrast, colon cell line results suggest that histone acetylation may play a role in YPEL3 regulation in colon cancer. | 21267786 |
| Adenocarcinoma of colon | Epigenetic Alterations | Histone acetylation may be a relevant epigenetic modulator of YPEL3 in colon adenocarcinomas. | 21267786 |
| Malignant Neoplasms | Epigenetic Alterations | Although the precise molecular mechanisms by which LOI of IGF2 increases GC risk require further study, LOI of IGF2 may be a potentially important clinical epigenetic marker to identify individuals at increased risk for gastric malignancy. | 21268128 |
| Primary malignant neoplasm, Neoplasm Metastasis | Epigenetic Alterations | The accumulation of a single microRNA in the bone marrow has the potential to regulate the translation of multiple genes in cancer metastasis and may therefore serve as a prognostic marker for cancer recurrence. | 21271219 |
| Breast Carcinoma | Epigenetic Alterations | The much higher significant correlation with microRNA levels and prognosis suggests epistatic effects on multiple target genes in the bone marrow of breast cancer patients. | 21271219 |
| Breast Carcinoma | Epigenetic Alterations | Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients. | 21271219 |
| Breast Carcinoma | Epigenetic Alterations | Accumulation of two of these microRNAs, miR-21 and miR-181a, in the recurrent breast cancer cases was validated by RT-PCR in bone marrow from 291 additional breast cancer cases. | 21271219 |
| Colorectal Cancer Pathway, Premalignant | Epigenetic Alterations | To evaluate association between DNA methylation of MAL, CDKN2A, and MGMT in stool and development of colorectal cancer, and to evaluate the screening value of these biomarkers in colorectal cancer and pre-malignant lesions. | 21271382 |
| Colorectal Cancer Pathway, Premalignant, Colonic adenomas | Epigenetic Alterations | DNA methylations levels of MAL, CDKN2A, and MGMT in stools are significantly higher in colorectal cancer and colon adenoma, which may serve as an noninvasive approach for the screening of colorectal cancer and pre-malignant lesions. | 21271382 |
| melanoma, Neoplasms | Epigenetic Alterations | The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker. | 21273047 |
| melanoma | Epigenetic Alterations | MicroRNA-221 (miR-221) is known to be abnormally expressed in malignant melanoma (MM) cells, and it favors the induction of the malignant phenotype through down-modulation of p27Kip1/CDKN1B and the c-KIT receptor. | 21273047 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | To prove the epigenetic regulation of OPCML, five bladder cancer cell lines were exposed to 5-aza-2deoxycytidine (5-aza-dC), a specific DNA methyltransferase inhibitor and trichostatin A (TSA), a histone deacetylase inhibitor. | 21273058 |
| Carcinoma, Transitional Cell, Transitional cell carcinoma of bladder, Carcinogenesis | Epigenetic Alterations | The high frequency of OPCML promoter methylation in urothelial carcinomas suggests an important role for this epigenetic alteration in bladder carcinogenesis, highlighting its potential as an epigenetic biomarker for bladder urothelial carcinoma with prognostic significance. | 21273058 |
| Gastric Cardia Adenocarcinoma | Epigenetic Alterations | Epigenetic silencing of Wnt-antagonist genes expression by promoter hypermethylation may play an important role in gastric cardia adenocarcinoma. | 21275459 |
| Papillary thyroid carcinoma | Epigenetic Alterations | Development of a microRNA-based molecular assay for the detection of papillary thyroid carcinoma in aspiration biopsy samples. | 21275764 |
| Thyroid Neoplasm | Epigenetic Alterations | miRNA quantification for differential diagnosis of thyroid neoplasms within aspiration biopsy samples is feasible and may improve the accuracy of FNAB cytology. | 21275764 |
| Carcinoma of lung | Epigenetic Alterations | Recently, epigenetic aberration of lung cancer, not only genomic DNA methylation but also chromatin modification, has become an important target for lung cancer research, although previous research has demonstrated that lung cancer develops as a result of both environmental and genetic factors. | 21276135 |
| Malignant tumor of colon | Epigenetic Alterations | Moreover, DNA methylation of selected ECM genes helps to stratify the high-risk stage 2 colon cancers patients who would benefit from adjuvant chemotherapy (HR: 5.85, 95% CI: 2.03-16.83, P = 0.001 for simultaneous methylation of IGFBP3, EVL, and CD109). | 21278247 |
| Clinical Coordinator | Epigenetic Alterations | We identified 29 low frequency-mutated genes that are also inactivated by epigenetic mechanisms in CRC. | 21278247 |
| Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | CRC that have silenced genes in ECM pathway components show worse survival suggesting that our finding provides novel prognostic biomarkers for CRC and reflects the high importance of integrative analyses linking genetic and epigenetic abnormalities with pathway disruption in cancer. | 21278247 |
| Hollings Cancer Center | Epigenetic Alterations | Recent reports suggest a link between aberrant expression of miRNA, and HCC. | 21278583 |
| Liver carcinoma | Epigenetic Alterations | Circulating microRNAs as biomarkers for hepatocellular carcinoma. | 21278583 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | In addition to genetic and epigenetic alterations, some genetic polymorphisms in the genes associated with the Wnt signaling pathway have been reported to be associated with an increased risk of cancer, including breast cancer. | 21279955 |
| Autoimmune Diseases | Epigenetic Alterations | MicroRNA reflect physiologic and pathologic processes and may be used as biomarkers of concurrent pathophysiologic events in complex settings such as autoimmune diseases. | 21280008 |
| Stomach Carcinoma | Epigenetic Alterations | Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. | 21281785 |
| Stomach Carcinoma | Epigenetic Alterations | Furthermore, epigenetic alterations in CA9 differ between the intestinal and diffuse types of gastric cancer. | 21281785 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | DNA methylation changes following 5-azacitidine treatment in patients with myelodysplastic syndrome. | 21286011 |
| Childhood Leukemia | Epigenetic Alterations | Furthermore, we found that Evi1 binds to several polycomb group proteins and recruits polycomb repressive complexes for PTEN down-regulation, which shows a novel epigenetic mechanism of AKT/mTOR activation in leukemia. | 21289308 |
| Metastasis, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Neoplasms | Epigenetic Alterations | MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. | 21294122 |
| Neoplasm Metastasis | Epigenetic Alterations | MicroRNA-200c (miR200c) is emerging as an important regulator of tumourigenicity and cancer metastasis with a strong capacity for inducing epithelial-mesenchymal transitions. | 21294122 |
| Parkinson Disease | Epigenetic Alterations | Identification of blood microRNAs associated to Parkinsonis disease. | 21295623 |
| Alzheimers Disease | Epigenetic Alterations | DNA methylation in repetitive elements and Alzheimer disease. | 21296655 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | Epigenetics is believed to play a role in Alzheimers disease (AD). | 21296655 |
| X-linked inheritance, Autosome | Epigenetic Alterations | We used quantitative mRNA expression and DNA methylation analyses to determine the relationship between expression and methylation of X-linked (MAGE-A1, NY-ESO-1, XAGE-1) and autosomal (BORIS, SOHLH2) CG genes, global DNA methylation (5mdC levels, LINE-1, Alu, and Sat-a methylation), and clinicopathology, using 75 EOC samples. | 21296871 |
| Neoplasms | Epigenetic Alterations | High-level DNA methylation was found in 16% of chromosomal instable tumors and in 44% of both microsatellite instable and microsatellite and chromosomally stable carcinomas. | 21297586 |
| Cervical Intraepithelial Neoplasia, Adenocarcinoma of small intestine | Epigenetic Alterations | Genetics and epigenetics of small bowel adenocarcinoma: the interactions of CIN, MSI, and CIMP. | 21297586 |
| Neoplasms | Epigenetic Alterations | Characterization of tumor genetics and epigenetics allows to stratify a tumor entity according to molecular pathways and may shed light on the interactions of different types of DNA alterations during tumorigenesis. | 21297586 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan Criteria. | 21298008 |
| Hollings Cancer Center | Epigenetic Alterations | MicroRNA profiling can predict HCC recurrence in Milan criteria cases. | 21298008 |
| Clinical Coordinator | Epigenetic Alterations | However, there is limited knowledge of the DNA methylation pattern in CRC. | 21298349 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations. | 21298349 |
| Primary malignant neoplasm | Epigenetic Alterations | Most human cancer types result from the accumulation of multiple genetic and epigenetic alterations in a single cell. | 21301064 |
| Sjogrens Syndrome | Epigenetic Alterations | Alterations in type I hemidesmosome components suggestive of epigenetic control in the salivary glands of patients with Sjogrens syndrome. | 21305504 |
| Cervical Intraepithelial Neoplasia | Epigenetic Alterations | High-risk human papillomavirus reduces the expression of microRNA-218 in women with cervical intraepithelial neoplasia. | 21309487 |
| Hematologic Neoplasms | Epigenetic Alterations | Epigenetic inactivation of the hsa-miR-203 in haematological malignancies. | 21323860 |
| Neoplasms | Epigenetic Alterations | miR-203 is a tumour suppressor microRNA (miRNA). | 21323860 |
| Lymphoma, Non-Hodgkin, Acute lymphocytic leukemia, Myeloid Leukemia, Chronic, Lymphoma, Large-Cell, Follicular, Chronic Lymphocytic Leukemia, Leukemia, Myelocytic, Acute | Epigenetic Alterations | We studied the methylation of hsa-miR-203 in 150 samples including acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), chronic myeloid leukaemia (CML), chronic lymphocytic leukaemia (CLL) and non-Hodgkins lymphoma (NHL) by methylation-specific PCR, and miRNA expression by stem-loop RT-qPCR. | 21323860 |
| Lymphoma, Large-Cell, Follicular, Neoplasms | Epigenetic Alterations | In NHL, hsa-miR-203 methylation was associated with concomitant methylation of other tumour suppressor miRNAs. | 21323860 |
| Malignant neoplasm of endometrium, Type 2 | Epigenetic Alterations | This raises the hypothesis that one-carbon nutrients (folate, methionine, and the enzymic cofactors vitamins B2, B6, and B12), which mediate chromosomal stability and DNA methylation, may be protective for type II but not type I endometrial cancer. | 21324952 |
| Mitral Valve Stenosis, Atrial Fibrillation | Epigenetic Alterations | MicroRNA expression signature in atrial fibrillation with mitral stenosis. | 21325063 |
| Microbiology Susceptibility Domain, Atrial Fibrillation | Epigenetic Alterations | miRNA arrays revealed that 136 and 96 miRNAs were expressed at different levels in MS patients with AF and in MS patients without AF, respectively, compared with healthy controls. | 21325063 |
| Colorectal Carcinoma | Epigenetic Alterations | Only HLTF, HPP1/TPEF, and NEUROG1 DNA methylation was detectable in at least 50% of patients with colorectal cancers. | 21326223 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The quantitative detection of NEUROG1 DNA methylation in serum is a suitable approach for the non-invasive screening for asymptomatic colorectal cancer. | 21326223 |
| Malignant Neoplasms, Hereditary | Epigenetic Alterations | Our results highlight the importance of epigenetic events in hereditary and sporadic cancers and suggest that MS-MLPA is an excellent choice for quantitative analysis of methylation in archival formalin-fixed, paraffin-embedded samples, which pose challenges to many other techniques commonly used for methylation studies. | 21327300 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small noncoding RNAs that contribute to tumorigenesis by acting as oncogenes or tumor suppressor genes and may be important in the diagnosis, prognosis and treatment of cancer. | 21327300 |
| Carcinoma, Hereditary | Epigenetic Alterations | Altered methylation at microRNA-associated CpG islands in hereditary and sporadic carcinomas: a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)-based approach. | 21327300 |
| Neoplasms, Hereditary Diseases | Epigenetic Alterations | The frequencies with which the individual miRNA loci were affected in tumors showed statistically significant differences relative to the tissue of origin (colorectal versus gastric versus endometrial), MMR proficiency versus deficiency and sporadic versus hereditary disease. | 21327300 |
| Neoplasms | Epigenetic Alterations | Hypermethylation at miRNA loci correlated with hypermethylation at classic tumor suppressor promoters in the same tumors. | 21327300 |
| Malignant Neoplasms, Hereditary Malignant Neoplasm, Hereditary | Epigenetic Alterations | Compared with sporadic cancers, the role of miRNAs in hereditary or familial cancer is poorly understood. | 21327300 |
| Neoplasms | Epigenetic Alterations | Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152 and 18b; decreased methylation for 200a and 208a; and no major change for 373 and let-7a-3. | 21327300 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Identification of a risk dependent microRNA expression signature in myelodysplastic syndromes. | 21332710 |
| SF3B1 wt Allele | Epigenetic Alterations | We identified a thirteen microRNA signature with statistically significant differential expression between normal and MDS specimens (P < 0*01), including down-regulation of members of the leukaemia-associated MIRLET7 family. | 21332710 |
| Neoplasms | Epigenetic Alterations | MicroRNAs play an important role in tumour suppression and the regulation of self-renewal and differentiation of haematopoietic progenitors. | 21332710 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions. | 21340720 |
| Cytogenetically normal acute myeloid leukemia, Leukemia, Myelocytic, Acute | Epigenetic Alterations | To determine the frequency of TET2 mutations, their associations with clinical and molecular characteristics and outcome, and the associated gene- and microRNA-expression signatures in patients with primary cytogenetically normal acute myeloid leukemia (CN-AML). | 21343549 |
| SMIM6 gene | Epigenetic Alterations | We identified a TET2 mutation-associated gene-expression signature in favorable-risk but not in intermediate-I-risk patients and found distinct mutation-associated microRNA signatures in both ELN groups. | 21343549 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer. | 21343564 |
| malignant disease | Epigenetic Alterations | Changes in DNA methylation in nontarget tissues, specifically peripheral blood, can also affect risk of malignant disease. | 21343564 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | We sought to identify specific profiles of DNA methylation in peripheral blood that are associated with bladder cancer risk and therefore serve as an epigenetic marker of disease susceptibility. | 21343564 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | In a training set of 112 cases and 118 controls, we identified a panel of 9 CpG loci whose profile of DNA methylation was significantly associated with bladder cancer in a masked, independent testing series of 111 cases and 119 controls (P < .0001). | 21343564 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations in tissues targeted for cancer play a causal role in carcinogenesis. | 21343564 |
| Malignant neoplasm of urinary bladder, Malignant Neoplasms | Epigenetic Alterations | These results indicate that profiles of epigenetic states in blood are associated with risk of bladder cancer and signal the potential utility of epigenetic profiles in peripheral blood as novel markers of susceptibility to this and other malignancies. | 21343564 |
| Neoplasms | Epigenetic Alterations | Weaker associations in CRLM suggest involvement of other unknown factors possibly from the liver microenvironment or resulting from additional genetic or epigenetic changes that drive tumour metastatic capability in OPN transcriptional control. | 21343932 |
| Prostate Cancer Pathway | Epigenetic Alterations | Improvement of prostate cancer detection by integrating the PSA test with miRNA expression profiling. | 21345070 |
| DICER1 protein, human | Epigenetic Alterations | The RNASE III endonuclease Dicer is one of the key enzymes of microRNA biogenesis. | 21345667 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Strong expression of the central microRNA biosynthesis enzyme Dicer predicts poor prognosis in patients with colorectal cancer. | 21345667 |
| Neoplasms | Epigenetic Alterations | We profiled miRNA expression in stage I EOC tumours to assess whether there is a miRNA signature associated with overall and progression-free survival (PFS) in stage I EOC. | 21345725 |
| Neoplasms | Epigenetic Alterations | 89 samples from tumour tissue collection A were stratified into a training set (51 samples, 15 of which were from patients who relapsed) for miRNA signature generation, and into a validation set (38 samples, seven of which were from patients who relapsed) for signature validation. | 21345725 |
| Hantavirus Infections | Epigenetic Alterations | Genetic or epigenetic alterations in DNMT genes do not appear to be associated with HPS, but further investigation of genetic variation at rs62106244 is justified given the high frequency of the minor allele in this case series. | 21347319 |
| Primary malignant neoplasm | Epigenetic Alterations | Normal proliferating cells and cancer cells express the sense mitochondrial ncRNA (SncmtRNA). | 21347712 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-146a is down-regulated in gastric cancer and regulates cell proliferation and apoptosis. | 21347720 |
| Malignant Neoplasms, Stomach Carcinoma | Epigenetic Alterations | Aberrant expression of microRNA-146a (miR-146a) has been reported to be involved in development and progression in various types of cancers, but its role in gastric cancer has not been fully elucidated. | 21347720 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer. | 21347785 |
| Pancreatic carcinoma | Epigenetic Alterations | Our aim was to identify promising microRNAs as markers to predict responses to gemcitabine in patients with resected pancreatic cancer. | 21347785 |
| Pancreatic carcinoma | Epigenetic Alterations | Eleven miRNAs were selected as putative predictive markers and analyzed by means of macrodissected formalin-fixed, paraffin-embedded samples obtained from 90 patients with or without gemcitabine treatment after resection of pancreatic cancer. | 21347785 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | There is increasing evidence that altered microRNA expression is associated with tumor progression and survival in cancer patients. | 21350005 |
| Adenocarcinoma of lung, stage I | Epigenetic Alterations | We tested if the expression of specific microRNAs was associated with prognosis and disease progression in early-stage lung adenocarcinoma. | 21350005 |
| Prostate Cancer Pathway, Carcinogenesis, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | There have been several reports of miRNA deregulation in prostate cancer (PCa) and the biological evidence for an involvement of miRNAs in prostate tumorigenesis is increasing. | 21351256 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. | 21351266 |
| Neoplasms | Epigenetic Alterations | From the surgical tissues, 7 miRNAs with significantly altered expression were identified, of which "4" were overexpressed and "3" were underexpressed in all 20 tumors. | 21351266 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Epigenetic alteration, using promoter hypermethylation of hMLH1 gene, is important for the development of head and neck squamous cell carcinoma (HNSCC). | 21353335 |
| SF3B1 wt Allele | Epigenetic Alterations | Therefore, zo-1 gene hypermethylation may be served as a useful epigenetic marker in the differential diagnosis for MDS. | 21362226 |
| Stomach Carcinoma | Epigenetic Alterations | Methylation-specific PCR (MS-PCR) was used to detect the DNA methylation status of hsa-miR-124a in gastric cancer tissues and adjacent normal tissues from 30 patients. | 21365509 |
| Multiple Sclerosis | Epigenetic Alterations | Changed histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions. | 21368055 |
| Multiple Sclerosis | Epigenetic Alterations | Here, we report, in humans brains, a shift toward histone acetylation in the white matter of the frontal lobes of aged subjects and in patients with chronic multiple sclerosis (MS). | 21368055 |
| Endometrial Neoplasms | Epigenetic Alterations | Microsatellite instability and DNA methylation of endometrial tumors and clinical features in young women compared with older women. | 21370598 |
| Malignant Neoplasms | Epigenetic Alterations | We have assayed cancers for microsatellite instability (MSI) and DNA methylation from a large group of patients younger than 50 years and a comparable group of older women. | 21370598 |
| Malignant Neoplasms | Epigenetic Alterations | On the basis of previous reports on methylation in other cancers, we hypothesized that the absence of RSK4 transcript is associated with epigenetic silencing rather than mutation. | 21372219 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | microRNA expression profiling of nasopharyngeal carcinoma. | 21373758 |
| Breast Carcinoma | Epigenetic Alterations | microRNA (miRNA) are short, noncoding RNA that negatively regulate gene expression and may play a causal role in invasive breast cancer. | 21375733 |
| Invasive carcinoma of breast | Epigenetic Alterations | Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer. | 21375733 |
| Neoplasms | Epigenetic Alterations | Since many genetic aberrations of invasive disease are detectable in early stages, we hypothesized that miRNA expression dysregulation and the predicted changes in gene expression might also be found in early breast neoplasias. | 21375733 |
| Ductal Carcinoma, Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | Expression profiling of 365 miRNA by real-time quantitative polymerase chain reaction assay was combined with laser capture microdissection to obtain an epithelium-specific miRNA expression signature of normal breast epithelium from reduction mammoplasty (RM) (n = 9) and of paired samples of histologically normal epithelium (HN) and ductal carcinoma in situ (DCIS) (n = 16). | 21375733 |
| Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | Thirty-five miRNA were aberrantly expressed between RM, HN and DCIS. | 21375733 |
| Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | Twenty-nine miRNA and 420 mRNA were aberrantly expressed between HN and DCIS. | 21375733 |
| Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | Knockdown of the putative oncogenic miRNA miR-182 and miR-183, both highly overexpressed in DCIS, increased the expression of chromobox homolog 7 (CBX7) (which regulates E-cadherin expression), DOK4, NMT2 and EGR1. | 21375733 |
| Invasive carcinoma of breast | Epigenetic Alterations | These data provide the first miRNA expression profile of normal breast epithelium and of preinvasive breast carcinoma. | 21375733 |
| Malignant Neoplasms | Epigenetic Alterations | Further, we demonstrate that altered miRNA expression can modulate gene expression changes that characterize these early cancers. | 21375733 |
| Breast Carcinoma | Epigenetic Alterations | We conclude that miRNA dysregulation likely plays a substantial role in early breast cancer development. | 21375733 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma. | 21375764 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | No significant relation was observed between aberrant DNA methylation of P16, MGMT and hMLH1 gene, as well as MTHFR C677T genetic polymorphisms and the prognosis of ESCC. | 21375764 |
| Neoplasms, Prostate carcinoma | Epigenetic Alterations | Herein we report that in a large and diverse cohort of prostate carcinoma samples, miR-221 is down-regulated in patients with tumours bearing TMPRSS2:ERG fusion transcripts, thus providing a link between miRNA and gene fusion expression. | 21378318 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Neoplasms | Epigenetic Alterations | miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma. | 21378409 |
| Hypopharyngeal Squamous Cell Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Based on the microRNA (miRNA) expression signatures of hypopharyngeal and esophageal squamous cell carcinoma, we found that miR-1 was significantly down-regulated in cancer cells. | 21378409 |
| Neoplasms | Epigenetic Alterations | Our data indicate that TAGLN2 may have an oncogenic function and may be regulated by miR-1, a tumor suppressive miRNA in HNSCC. | 21378409 |
| SERPINB3 wt Allele, Neoplasms | Epigenetic Alterations | Hypermethylation of CpG islands is a common epigenetic mechanism that leads to gene silencing in tumors and could be a useful biomarker in OSCC. | 21380558 |
| Neoplasms | Epigenetic Alterations | Suppression of miR-218 was associated with epigenetic silencing of SLIT2 and SLIT3, ligands of ROBO receptors that have been previously implicated in tumor angiogenesis. | 21385904 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL). | 21386967 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia. | 21386967 |
| Acute lymphocytic leukemia | Epigenetic Alterations | All these findings indicate that TP53 pathway is altered by epigenetic mechanisms in the majority of ALL patients and correlates with prognosis. | 21386967 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Treatments with compounds that may reverse the epigenetic abnormalities or activate directly the p53 pathway represent a new therapeutic alternative for patients with ALL. | 21386967 |
| Carcinoma of lung, Chronic Obstructive Airway Disease | Epigenetic Alterations | Specific peripheral miRNA profiles for distinguishing lung cancer from COPD. | 21388703 |
| Carcinoma of lung | Epigenetic Alterations | Recently we reported differential miRNA signatures in blood cells of lung cancer patients and healthy controls. | 21388703 |
| Carcinoma of lung, Chronic Obstructive Airway Disease | Epigenetic Alterations | The miRNA pattern from patients with lung cancer and COPD were more similar to each other than to the healthy controls. | 21388703 |
| Carcinoma of lung, Chronic Obstructive Airway Disease | Epigenetic Alterations | In conclusion, we showed that blood miRNA signatures are suitable to distinguish lung cancer from COPD. | 21388703 |
| Carcinoma of lung, Chronic Obstructive Airway Disease | Epigenetic Alterations | We compared the expression of 863 human miRNAs in blood cells of lung cancer patients, COPD patients, and healthy controls. | 21388703 |
| Carcinoma of lung, Chronic Obstructive Airway Disease | Epigenetic Alterations | In total, 140 miRNAs were significant for the comparison COPD and controls, 61 miRNAs were significant for the comparison lung cancer and controls, and 14 miRNAs were significant for the comparison lung cancer and COPD. | 21388703 |
| Carcinoma of lung, Non-Malignant | Epigenetic Alterations | The predicted mRNA targets of three of the 14 miRNAs were significantly up-regulated in PBMCs of lung cancer patients compared to patients with non-malignant lung diseases. | 21388703 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-301 mediates proliferation and invasion in human breast cancer. | 21393507 |
| Breast Carcinoma | Epigenetic Alterations | Several microRNAs have been implicated in human breast cancer but none to date have been validated or utilized consistently in clinical management. | 21393507 |
| Primary malignant neoplasm | Epigenetic Alterations | The concentrations of cell-free DNA (p = 0.0001), serum microRNAs (p = 0.0001) and caspase activities (p = 0.0001) significantly discriminated cancer patients from healthy individuals. | 21398193 |
| Carcinoma of lung | Epigenetic Alterations | The findings of our pilot study suggest that the assays for circulating DNA, microRNAs and caspase activities in blood might become novel minimally invasive diagnostic tools for detection and risk assessment of lung cancer, provided that their clinical utility can be confirmed in larger prospective trials. | 21398193 |
| Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumor-suppressive microRNAs (miRNAs) is a key oncogenic mechanism for the activation of oncogenes in tumors. | 21399664 |
| Neoplasms, Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia. | 21399664 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Among these miRNAs, miR-193a was embedded in a CpG island and epigenetically repressed by promoter hypermethylation in acute myeloid leukemia (AML) cell lines and primary AML blasts, but not in normal bone marrow cells. | 21399664 |
| Breast Cancer Cell, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer. | 21399871 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA miR-125b is a prognostic marker in human colorectal cancer. | 21399871 |
| Carcinogenesis | Epigenetic Alterations | The criteria combining DNA methylation status for the 30 regions including the 45 CpG sites were able to diagnose N as being at high risk of carcinogenesis with 100% sensitivity and specificity in the learning cohort and 95.6% sensitivity and 100% specificity in the validation (n=90) cohort. | 21400512 |
| Hepatitis, Hepatitis B, Liver Cirrhosis | Epigenetic Alterations | The DNA methylation status of the 30 regions did not depend on the presence or absence of hepatitis virus infection, or the status of noncancerous liver tissue (chronic hepatitis or cirrhosis). | 21400512 |
| Prostate carcinoma | Epigenetic Alterations | MicroRNA profiles of prostate carcinoma detected by multiplatform microRNA screening. | 21400514 |
| Prostate Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | To characterize the diagnostic potential of miRNAs in prostate cancer, a leading cause of cancer mortality, we performed screening of miRNA expression profiles. | 21400514 |
| Primary malignant neoplasm | Epigenetic Alterations | We used commercially available microarrays to establish miRNA expression profiles from a cohort of 20 cancer samples. | 21400514 |
| Primary malignant neoplasm | Epigenetic Alterations | We identified 25 miRNAs that showed a significant differential expression in cancer samples. | 21400514 |
| Prostate Cancer Pathway | Epigenetic Alterations | Our data extend the knowledge about the deregulation of miRNAs in prostate cancer. | 21400514 |
| Neoplasms | Epigenetic Alterations | The differential expression of several miRNAs is highly consistent using independent cohorts of tumor samples, different tissue preservation methods and different experimental methods. | 21400514 |
| Prostate Cancer Pathway | Epigenetic Alterations | Our results indicate that combinations of miRNAs are promising biomarkers for the diagnosis of prostate cancer. | 21400514 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | To decipher the epigenetic alterations during the development of liver metastasis, the DNA methylation status of 12 genes, including 5 classical CpG island methylator phenotype (CIMP) markers, was analyzed in 62 liver metastases and in 78 primary CRCs (53 stage I-III; 25 stage IV). | 21406167 |
| Colorectal Carcinoma, Metastasis | Epigenetic Alterations | Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasis. | 21406167 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway, Clinical Coordinator | Epigenetic Alterations | Liver metastasis is a fatal step in the progression of colorectal cancer (CRC); however, the epigenetic evolution of this process is largely unknown. | 21406167 |
| Mycosis Fungoides | Epigenetic Alterations | miRNA expression profiling of mycosis fungoides. | 21406335 |
| Childhood Leukemia, Sezary Syndrome, Seizures | Epigenetic Alterations | Previously we examined the miRNA profile of Sezary syndrome (Sz), a leukemia of skin-homing memory T cells. | 21406335 |
| Inflammatory dermatosis, Lichen Planus, Eczema, Neoplasms | Epigenetic Alterations | The miRNA profile of skin biopsies from 19 patients with tumor stage MF and 12 patients with benign inflammatory dermatoses (eczema and lichen planus) were compared by microarray analysis. | 21406335 |
| Neoplasms | Epigenetic Alterations | Differential expression of a selection of these miRNAs was validated by miRNA-Q-PCR on additional test groups (tumors and controls). | 21406335 |
| Neoplasms | Epigenetic Alterations | Taken together this report is the first describing the miRNA signature of tumor stage MF. | 21406335 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many malignancies including lymphoma. | 21406335 |
| Inflammatory dermatosis, Neoplasms | Epigenetic Alterations | We identified 49 miRNAs that are differentially expressed in tumor stage MF compared to benign inflammatory dermatoses using ANOVA analysis (P < 0.05, Benjamini-Hochberg corrected). | 21406335 |
| Neoplasms | Epigenetic Alterations | The majority of the differentially expressed miRNAs (30/49) were up-regulated in tumor stage MF. | 21406335 |
| Neoplasms | Epigenetic Alterations | None of the miRNAs up-regulated in tumor stage MF was previously shown to be up-regulated in Sz, and only 2 of the 19 miRNAs down-regulated in tumor stage MF were also down-regulated in Sz. | 21406335 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer. | 21406965 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer. | 21412018 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | The clinical significance of microRNA-21 (miR-21) and miR-155 in colorectal cancer (CRC) patients remains elusive. | 21412018 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays, and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR (RT-PCR). | 21412018 |
| Lipoma | Epigenetic Alterations | Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs, we did not observe a significant link with let-7 inhibition in such cases. | 21412931 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Alterations in DNA methylation have been implicated in the pathogenesis of myelodysplastic syndromes (MDS), although the underlying mechanism remains largely unknown. | 21415852 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small noncoding RNAs that regulate the expression of protein-encoding genes and are involved in the development, progression and prognosis of other malignancies. | 21420070 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | MicroRNA prognostic signature for nodal metastases and survival in esophageal adenocarcinoma. | 21420070 |
| Malignant neoplasm of esophagus | Epigenetic Alterations | We hypothesized that global miRNA expression would predict survival and lymph node involvement in a cohort of surgically resected esophagus cancer patients. | 21420070 |
| Malignant neoplasm of esophagus | Epigenetic Alterations | These results suggest miRNA expression profiling could provide prognostic utility in staging esophagus cancer patients and treatment planning with endoscopic and neoadjuvant therapies. | 21420070 |
| Metastasis | Epigenetic Alterations | The expression of three miRNAs (miR-99b and miR-199a_3p and _5p) was also associated with the presence of lymph node metastasis. | 21420070 |
| Huntington Disease | Epigenetic Alterations | Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntingtons disease. | 21421997 |
| Glioblastoma Multiforme | Epigenetic Alterations | Epigenetic silencing of the O(6) -methylguanine-DNA methyltransferase (MGMT) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). | 21425258 |
| Admitting diagnosis | Epigenetic Alterations | These observations suggest that coordinated transcriptional changes associated with ageing and calcium homeostasis in the human brain are accelerated in patients with AD. | 21425351 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | [DNA methylation of tumor suppressor genes located on chromosome 3p in non-small cell lung cancer]. | 21426665 |
| Imprinting (Psychology), Alloisoleucine | Epigenetic Alterations | Loss of imprinting (LOI) is an epigenetic alteration involving loss of parental origin-specific expression at normally imprinted genes. | 21432864 |
| Prostate Cancer Pathway | Epigenetic Alterations | These data provide evidence for a widespread epigenetic field defect in histologically normal tissues that might be employed to identify prostate cancer in patients. | 21432864 |
| Loss of Heterozygosity | Epigenetic Alterations | The relationship between these polymorphisms and the frequently observed genetic and/or epigenetic aberrations, TP53 loss of heterozygosity (LOH), 1p34 LOH, retinoblastoma-1 (RB1) LOH, p16 inactivation and epidermal growth factor receptor aberrations, was then assessed. | 21435097 |
| Primary malignant neoplasm | Epigenetic Alterations | We previously identified a functional variant in a let-7 microRNA (miRNA) complementary site in the 3-untranslated region of the KRAS oncogene (rs61764370) which is associated with cancer. | 21435948 |
| Breast Carcinoma, Triple-Negative Breast Cancer Finding | Epigenetic Alterations | The KRAS variant might be a genetic marker for development of triple-negative breast cancer in premenopausal women, and altered gene and miRNA expression signatures should enable molecular and biological stratification of patients with this subgroup of breast cancer. | 21435948 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus. | 21436623 |
| Lupus Erythematosus | Epigenetic Alterations | We identified 236 hypomethylated and 105 hypermethylated CG sites in lupus CD4 (+) T cells compared to normal controls, consistent with widespread DNA methylation changes in lupus T cells. | 21436623 |
| Lupus Erythematosus | Epigenetic Alterations | Recent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus. | 21436623 |
| Primary malignant neoplasm | Epigenetic Alterations | Alterations in DNA methylation contribute to cancer development and progression. | 21438024 |
| Pituitary Adenoma | Epigenetic Alterations | It has been suggested that pituitary adenoma results from accumulation of multiple genetic and/or epigenetic aberrations, which may be identified through association studies. | 21439054 |
| Communicable Diseases, Skin carcinoma | Epigenetic Alterations | HPV-38 was predicted to express an miRNA conserved to human let-7a and the expression of let-7a, in HPV-38-positive non-melanoma skin cancer (NMSC) biopsies was 10-fold higher than those with HPV-positive (for other types except HPV-38) and HPV-negative NMSCs, suggesting that let-7a expression might be related to HPV-38 infection. | 21442230 |
| Communicable Diseases | Epigenetic Alterations | Potential gene targets of the predicted miRNA that may aid HPV in infection and pathogenesis were also analysed. | 21442230 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Reduced levels of global DNA methylation, assessed in peripheral blood, have been associated with bladder cancer risk in European and American populations. | 21445976 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Similar data are lacking in Asian populations where genetic differences, lifestyle factors and different environmental exposures may affect DNA methylation and its risk relationship with bladder cancer. | 21445976 |
| MYELODYSPLASTIC SYNDROME, Acute Myeloid Leukemia with Myelodysplasia-Related Changes, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Impaired mitochondrial gene transcription in myelodysplastic syndromes and acute myeloid leukemia with myelodysplasia-related changes. | 21447369 |
| Congenital contractural arachnodactyly, Cholangiocarcinoma | Epigenetic Alterations | Genetic changes have been widely reported in association with cholangiocarcinoma (CCA), while epigenetic changes are poorly characterised. | 21448164 |
| Metastasis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration. | 21448905 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA microarray profiling was performed on samples from clinically matched NSCLC from seven patients with BM (BM+) and six without BM (BM-). | 21448905 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We investigated miRNAs that may serve as biomarkers to differentiate between NSCLC patients with and without BM. | 21448905 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In summary, miR-328 has a role in conferring migratory potential to NSCLC cells working in part through PRKCA and with further corroboration in additional independent cohorts, these miRNAs may be incorporated into clinical treatment decision making to stratify NSCLC patients at higher risk for developing BM. | 21448905 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | With regard to miRNA-processing elements, the expression level of RNASEN was higher in ESCC than in normal epithelium (P < 0.05). | 21453382 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The findings may imply that miRNA biogenesis is aberrantly accelerated in ESCC. | 21453382 |
| Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma, Hodgkin Disease | Epigenetic Alterations | Epigenetic changes have been implicated in the loss of the B-cell program in classical Hodgkins lymphoma, and might provide a basis for the immunophenotypic alterations seen in mediastinal gray zone lymphoma. | 21454882 |
| Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma, Hodgkin Disease | Epigenetic Alterations | Based on the epigenetic profiles we were able to establish class prediction models utilizing genes such as HOXA5, MMP9, EPHA7 and DAPK1 which could distinguish between mediastinal gray zone lymphoma, classical Hodgkins lymphoma and primary mediastinal large B-cell lymphoma with a final combined prediction of 100%. | 21454882 |
| Pancreatic carcinoma | Epigenetic Alterations | Leukocyte DNA methylation signature differentiates pancreatic cancer patients from healthy controls. | 21455317 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Expression of microRNAs can affect age of tumor onset and prognosis of cancer patients. | 21455991 |
| sodium thiosulfate, Sarcoma, Primary malignant neoplasm | Epigenetic Alterations | However, nothing is known about the effects of microRNAs on altered age of cancer onset and disease-specific survival of soft-tissue sarcoma (STS) patients. | 21455991 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Functional implications of microRNAs in acute myeloid leukemia by integrating microRNA and messenger RNA expression profiling. | 21455993 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The expression of microRNAs (miRNAs) is deregulated in acute myeloid leukemia (AML), but the corresponding functional miRNA-controlled pathways are poorly understood. | 21455993 |
| Leukemogenesis | Epigenetic Alterations | Integration of messenger RNA (mRNA) and miRNA expression profiling may allow the identification of functional links between the whole transcriptome and microRNome that are involved in myeloid leukemogenesis. | 21455993 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Our results indicate that by integrating the transcriptome and microRNome in AML cells, it is possible to identify previously unidentified putative functional miRNA-mRNA interactions in AML. | 21455993 |
| Liver carcinoma | Epigenetic Alterations | Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma. | 21458843 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-221, microRNA-222, and microRNA-21 were differentially overexpressed in hepatocellular carcinoma compared with nonneoplastic and normal livers (P < .001). | 21458843 |
| Carcinoma | Epigenetic Alterations | The mean fold changes in microRNA-221, microRNA-222, and microRNA-21(hepatocellular carcinoma to matched nonneoplastic liver) were 4.00, 4.44, and, 3.67, respectively. | 21458843 |
| Liver carcinoma | Epigenetic Alterations | High expression of microRNA-221 in hepatocellular carcinomas was significantly related to shorter time to local recurrence (P < .001) and determined as an independent predictor for local recurrence (P = .001). | 21458843 |
| Hepatocarcinogenesis, Metastasis | Epigenetic Alterations | Based on these results, we propose the possible role of microRNA-221, microRNA-222, microRNA-21, and microRNA-155 dysregulation in hepatocarcinogenesis and the potential of microRNA-221 dysregulation for predicting local recurrence and distant metastasis after curative surgery. | 21458843 |
| Liver carcinoma | Epigenetic Alterations | Aberrant expression of specific microRNAs in hepatocellular carcinomas has recently been reported. | 21458843 |
| Carcinogenesis | Epigenetic Alterations | DNA methylation contributes to carcinogenesis by mediating transcriptional regulation and chromatin remodelling, which may influence the effect of DNA-damaging drugs. | 21458988 |
| ovarian neoplasm | Epigenetic Alterations | Consistent with their epigenetic regulation, reduced expression of FZD4, DVL1, and ROCK1 is an indicator of early-disease relapse in an independent ovarian tumor cohort (n = 311, adjusted P < 0.05). | 21459799 |
| ovarian neoplasm | Epigenetic Alterations | The data highlight the importance of epigenetic regulation of multiple promoter CGIs of Wnt pathway genes in ovarian cancer and identify methylation at NKD1 and DVL1 as independent predictors of PFS. | 21459799 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia. | 21460253 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | The levels of several of these circulating miRNAs also displayed significant differences between zeta-associated protein 70 (ZAP-70)(+) and ZAP-70(-) CLL. | 21460253 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | This hypothesis suggests the possibility of using the levels of specific miRNAs in plasma to detect CLL and to determine the ZAP-70 status. | 21460253 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant expression of miRNA has been associated with the development or progression of several diseases, including cancer. | 21460750 |
| Malignant Neoplasms, Virus Diseases | Epigenetic Alterations | Molecular and epidemiological data have unequivocally confirmed that high-risk human papillomaviruses (HPVs) are a major etiological agent of this malignancy, as host epigenetic alterations are induced in response to viral infection. | 21461574 |
| Neoplasms | Epigenetic Alterations | Differences in miRNA hypermethylation between the tumor and control samples were highly significant for all the genes tested (p<0.0001). | 21461574 |
| Neoplasms | Epigenetic Alterations | The lr-HPV precursor lesions had a methylation percent pattern similar to that of the normal samples, while the results for the hr-HPV precursor lesions and tumors indicate a possible involvement of the hr-HPV genotype in the miRNA methylation process. | 21461574 |
| Stomach Carcinoma | Epigenetic Alterations | Clinical significance of expression of Hint1 and potential epigenetic mechanism in gastric cancer. | 21468541 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | microRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells. | 21468550 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Abnormal expression of let-7a microRNA (miRNA) in non-small cell lung cancer (NSCLC) cells and tissue has been previously reported. | 21468581 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Aberrant expression of let-7a miRNA in the blood of non-small cell lung cancer patients. | 21468581 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The 2(-ddCt) of let-7a miRNA in the blood of normal subjects and those with NSCLC was 3242.49+-355.28 and 747.85+-177.74, respectively. | 21468581 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The 2(-ddCt) of let-7a miRNA in the normal human lung tissues and human NSCLC tissues was 42.30+-3.98 and 27.73+-3.86, respectively. | 21468581 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Let-7a miRNAs were under-expressed in the blood of NSCLC patients, as well as NSCLC cells and NSCLC tissues, compared to normal controls. | 21468581 |
| Autoimmune state | Epigenetic Alterations | MicroRNAs (miRNAs), small non-coding RNA molecules that post-transcriptionally regulate gene expression, are known to play key roles in regulating immune responses and autoimmunity. | 21469088 |
| Childhood Medulloblastoma | Epigenetic Alterations | Expression of KCASH2 and -3 is observed in cerebellum, whereas epigenetic silencing and allelic deletion are observed in human medulloblastoma. | 21472142 |
| CDKN2A Negative | Epigenetic Alterations | The genetic and epigenetic alterations frequently observed were EGFR amplification (51.5%), TP53 mutation (33.8%), CDKN2A loss (32.4%), TP53 loss (16.2%), methylation of the MGMT promoter (33.8%) and IDH1 mutation (5.9%). | 21472719 |
| Primary Neoplasm | Epigenetic Alterations | Aberrant DNA methylation of primary breast tumors can have impact on the clinical outcome. | 21479925 |
| 1-methyl-1-piperidinomethane sulfonate | Epigenetic Alterations | miRNAs isolated from fresh-frozen biopsies of MPM patients were tested for the expression of 88 types of miRNA involved in cancerogenesis. | 21483773 |
| Neoplasms | Epigenetic Alterations | Since recent data point to abnormal levels of microRNAs (miRNAs) in tumors, we hypothesized that a profile of deregulated miRNAs may be a marker of MPM and that the levels of specific miRNAs may be used for monitoring its progress. | 21483773 |
| Primary malignant neoplasm | Epigenetic Alterations | As the epigenetics of cancer are unraveled, KLK10 may represent not only a novel biomarker, but also a promising future therapeutic target for the disease. | 21487810 |
| Prostate Cancer Pathway | Epigenetic Alterations | The expression of 7 miRNAs in LNCaP, LNCaP-AI, and PC3 prostate cancer cell lines was detected by Northern blotting. | 21487968 |
| Malignant mesothelioma | Epigenetic Alterations | Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism. | 21489980 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | DNA methylation profile during multistage progression of pulmonary adenocarcinomas. | 21494759 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Multiple genetic and epigenetic alterations are known to be involved in the carcinogenesis of peripheral pulmonary adenocarcinoma (ADC). | 21494759 |
| Carcinogenesis | Epigenetic Alterations | Our results indicate that epigenetic alterations are involved in the multistep progression of pulmonary ADC development, and aberrant CpG island methylation accumulates during multistep carcinogenesis. | 21494759 |
| Invasive Lesion | Epigenetic Alterations | In addition, aberrant methylation of HOXA1, TMEFF2, and RARB occurred in preinvasive lesions, which indicates that epigenetic alterations of these genes are involved in the early stages of pulmonary ADC development. | 21494759 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Epigenetic regulation of cathepsin L expression in chronic myeloid leukaemia. | 21496199 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Do DNA-methylation and histone acetylation play a role in clear cell renal carcinoma? | 21496397 |
| Neoplasms | Epigenetic Alterations | The percentage of global DNA methylation was significantly higher in grades 3 and 4 tumors (p=0.033). | 21496397 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA; miR) is a class of small regulatory RNA molecules, the aberrant expression of which can lead to the development of cancer. | 21502955 |
| Neoplastic disease | Epigenetic Alterations | Leukemic mutations in all four genes have recently been implicated in aberrant DNA methylation, a hallmark of neoplasia. | 21504050 |
| Carcinogenesis | Epigenetic Alterations | These evidences held the role of oncosuppressor methylation in both colon tumorigenesis and progression and suggested that epigenetic events should be taken into account when biological therapies in mCRC patients have to be set. | 21506124 |
| Malignant tumor of colon | Epigenetic Alterations | DNA methylation predicts recurrence from resected stage III proximal colon cancer. | 21509761 |
| Clinical Coordinator, teratologic, Colorectal Cancer Pathway | Epigenetic Alterations | In colorectal cancer (CRC), DNA methylation anomalies define distinct subgroups termed CpG island methylator phenotype 1 (CIMP1), CIMP2, and CIMP-negative. | 21509761 |
| Clinical Coordinator | Epigenetic Alterations | DNA methylation is a useful biomarker of recurrence in resected stage III proximal but not distal CRC. | 21509761 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11. | 21510944 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNAs are widely dysregulated in various cancers and integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. | 21510944 |
| Primary Neoplasm | Epigenetic Alterations | We initially compared whole-genome patterns of DNA methylation among 24 OPSCC primary tumors and 24 matched normal mucosal samples. | 21514414 |
| Neoplasms | Epigenetic Alterations | From a survey of 27,578 CpG dinucleotide loci spanning more than 14,000 genes, we identified 958 CpG loci in which measurements of DNA methylation were altered in the primary tumors relative to the normal mucosal samples. | 21514414 |
| Oropharyngeal Carcinoma | Epigenetic Alterations | This study reports the epigenetic silencing of Kruppel-type zinc finger protein genes on chromosome 19q13 in oropharyngeal cancer. | 21514414 |
| Malignant neoplasm of urinary bladder, Best Case Imputation Technique | Epigenetic Alterations | However, the genetic or epigenetic regulations of these miRNAs have not yet been fully elucidated in bladder cancer (BC). | 21519788 |
| Malignant Neoplasms, Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Growing evidence suggests that microRNAs (miRNAs) are aberrantly expressed in many human cancers, and that they play significant roles in carcinogenesis and cancer progression. | 21519788 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | The identification of tumor suppressive miRNAs and their target genes could provide new insights into the mechanism of carcinogenesis. | 21519788 |
| Mental disorders | Epigenetic Alterations | The genetic, epigenetic and environmental factors may influence the risk for neuropsychiatric disease through their effects on gene transcription. | 21521424 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic changes in the methylation of the RUNX3 proximal promoter, but not common genetic changes in RUNX3, have been associated with both changes in the gene expression and development of the cancer. | 21523770 |
| Stomach Carcinoma | Epigenetic Alterations | In addition to epigenetic changes in the RUNX3 proximal promoter, genetic changes in the distal promoter may be associated with susceptibility to intestinal-type gastric cancer by increasing promoter activity. | 21523770 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | PGIS mRNA expression was regulated by DNA CpG methylation and histone acetylation in NSCLC cell lines, with chromatin remodeling taking place directly at the PGIS gene. | 21523772 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Prostacyclin synthase expression and epigenetic regulation in nonsmall cell lung cancer. | 21523772 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | The expression of specific miRNAs may be useful for DLBCL survival prediction and their role in the pathogenesis of this disease should be examined further. | 21525173 |
| Sezary Syndrome | Epigenetic Alterations | MicroRNA profiling reveals that miR-21, miR486 and miR-214 are upregulated and involved in cell survival in Sezary syndrome. | 21525938 |
| Metastasis | Epigenetic Alterations | MicroRNA profiling may be particularly helpful in patients in whom the IHC profile of the metastasis is nondiagnostic or leaves a large differential diagnosis. | 21531815 |
| Neoplasms | Epigenetic Alterations | Although microRNAs regulate all the major biological mechanisms, their influence on tumor microenvironment is largely unexplored. | 21532615 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | These results suggest the possible implication of BRCA1 promoter methylation in the early onset of breast cancer and propose the use of this epigenetic modification as a powerful molecular marker for detecting women potentially predisposed to cancer. | 21537840 |
| Papillary thyroid carcinoma | Epigenetic Alterations | MicroRNA signature distinguishes the degree of aggressiveness of papillary thyroid carcinoma. | 21537871 |
| F9 gene | Epigenetic Alterations | miRNA array was used to identify a subset of differentially expressed miRNAs between aggressive and nonaggressive PTC. | 21537871 |
| F9 gene | Epigenetic Alterations | The miRNA array identified miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC. | 21537871 |
| F9 gene | Epigenetic Alterations | Significant miRNA deregulation was confirmed in the validation cohort, with upregulation of miR-146b and miR-222 and downregulation of miR-34b and miR-130b seen in aggressive PTC. | 21537871 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are dysregulated in various tumors types, and some of them serve as markers of poor prognosis. | 21537871 |
| methionine, F9 gene, Neoplasms, ret/PTC | Epigenetic Alterations | These miRNAs were further validated by real-time RT-PCR in a cohort of 17 PTC with local tumor recurrence or distant metastases and 15 PTC with no extrathyroidal dissemination and correlated with BRAF, RAS, and RET/PTC mutations and MET expression. | 21537871 |
| methionine, F9 gene | Epigenetic Alterations | MET was identified as a potential target gene for 2 downregulated miRNAs (miR-34b and miR-1), and significantly higher level of MET expression was observed in aggressive PTC. | 21537871 |
| Colorectal Carcinoma | Epigenetic Alterations | [MicroRNA-221 controls CDKN1C/P57 expression in human colorectal carcinoma]. | 21538272 |
| Neoplasms | Epigenetic Alterations | The role of microRNA-155 (miR-155) has been associated with oncogenesis of several human tumors. | 21541331 |
| Colorectal Neoplasms | Epigenetic Alterations | Our results suggest that analysis of the methylation of DNA in mucosal wash fluid may be a good molecular marker for predicting the invasiveness of colorectal tumors. | 21543345 |
| Colorectal Neoplasms | Epigenetic Alterations | Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors. | 21543345 |
| Hematologic Neoplasms | Epigenetic Alterations | Epigenetic inactivation of the miR-124-1 in haematological malignancies. | 21544199 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic deregulation of miRs is implicated in carcinogenesis. | 21544199 |
| Neoplasms | Epigenetic Alterations | miR-124-1 is a tumour suppressor microRNA (miR). | 21544199 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer. | 21544802 |
| Carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | Circulating micro-RNA (miR) profiles have been proposed as promising diagnostic and prognostic biomarkers for cancer, including lung cancer. | 21544802 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-21 and PDCD4 expression in colorectal cancer. | 21546206 |
| Malignant tumor of colon | Epigenetic Alterations | This study was designed to determine whether DNA methylation biomarkers are associated with recurrence and survival in colon cancer patients. | 21551253 |
| Stomach Carcinoma | Epigenetic Alterations | Stem cell associated genes working with one miRNA cluster have different clinic pathologic values in gastric cancer. | 21553350 |
| Liver carcinoma | Epigenetic Alterations | Underexpressed microRNA-199b-5p targets hypoxia-inducible factor-1a in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients. | 21557766 |
| ovarian neoplasm | Epigenetic Alterations | Peripheral blood DNA methylation detected in the BRCA1 or BRCA2 promoter for sporadic ovarian cancer patients and controls. | 21557934 |
| ovarian neoplasm | Epigenetic Alterations | In most of sporadic ovarian cancer, variation in the expression of BRCA1 and BRCA2 genes was observed and it could be a consequence of epigenetic modifications. | 21557934 |
| ovarian neoplasm | Epigenetic Alterations | These results may have implications in better understanding the underlying epigenetic mechanisms in BRCA1 and BRCA2 oncosuppressors in sporadic ovarian cancer. | 21557934 |
| Glioblastoma Multiforme | Epigenetic Alterations | A specific miRNA signature in the peripheral blood of glioblastoma patients. | 21561454 |
| Glioblastoma Multiforme | Epigenetic Alterations | To this end, miRNA profiles from the blood of 20 patients with glioblastoma and 20 age- and sex-matched healthy controls were compared. | 21561454 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic regulation of microRNA-10b and targeting of oncogenic MAPRE1 in gastric cancer. | 21562367 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs act as negative regulators of gene expression, and the altered expression of microRNAs by epigenetic mechanisms is strongly implicated in carcinogenesis. | 21562367 |
| Stomach Carcinoma | Epigenetic Alterations | Here we report that the microRNA-10b gene (miR-10b) was silenced in gastric cancer cells by promoter methylation. | 21562367 |
| Secondary malignant neoplasm of rectum | Epigenetic Alterations | MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility. | 21562850 |
| Malignant Neoplasms, Breast Carcinoma, Metastasis | Epigenetic Alterations | Human microRNA-9 (miR-9) has been reported to be involved in the metastasis of several malignancies including brain breast cancer. | 21562850 |
| Primary malignant neoplasm | Epigenetic Alterations | Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy. | 21567082 |
| Colorectal Carcinoma | Epigenetic Alterations | miRNA-21 (miR-21) is upregulated and miR-143 and miR-145 are downregulated in colorectal carcinoma. | 21567082 |
| Neoplasms | Epigenetic Alterations | According to the predictive and prognostic value of the analyzed miRNAs, a significant correlation between miR-145 expression and tumor regression was seen. | 21567082 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNA let-7a: a potential marker for selection of paclitaxel in ovarian cancer management. | 21571355 |
| Prostate Cancer Pathway | Epigenetic Alterations | EFEMP1 as a novel DNA methylation marker for prostate cancer: array-based DNA methylation and expression profiling. | 21571867 |
| Prostatic Hyperplasia, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | DNA methylation and gene expression analysis in 203 human prostate specimens, including 106 PCa and 97 benign prostate hyperplasia (BPH), were carried out. | 21571867 |
| Clinical Coordinator | Epigenetic Alterations | The selected candidate prognostic miRNAs were validated in a cohort of 50 CRC patients by TaqMan quantitative PCR. | 21573504 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Germline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma. | 21584899 |
| Somatic, Primary malignant neoplasm | Epigenetic Alterations | In summary, we have identified KILLIN as a potential novel cancer predisposition gene for nonsyndromic clear-cell RCC, and the epigenetic mechanism of KILLIN inactivation in both the germline and somatic setting suggests the potential for treatment with demethylating agents. | 21584899 |
| Infection caused by Helicobacter pylori, Stomach Carcinoma | Epigenetic Alterations | Genome-wide DNA methylation profiles in noncancerous gastric mucosae with regard to Helicobacter pylori infection and the presence of gastric cancer. | 21585603 |
| Communicable Diseases, Helicobacter pylori | Epigenetic Alterations | To determine genome-wide DNA methylation profiles induced by Helicobacter pylori (H. pylori) infection and to identify methylation markers in H. pylori-induced gastric carcinogenesis. | 21585603 |
| Carcinoma of lung | Epigenetic Alterations | These findings suggest that DNA methylation may be important for downregulation of CFTR gene expression in lung cancer. | 21585618 |
| Ventricular hypertrophy, Aortic Valve Stenosis | Epigenetic Alterations | Myocardial gene expression of microRNA-133a and myosin heavy and light chains, in conjunction with clinical parameters, predict regression of left ventricular hypertrophy after valve replacement in patients with aortic stenosis. | 21586423 |
| Clinical Coordinator, Colorectal Neoplasms | Epigenetic Alterations | Wnt5a is a critical regulator of non-canonical Wnt activity and promoter hypermethylation of this gene has emerging prognostic roles in CRC; however the frequency and prognostic significance of this epigenetic event have not been explored in the context of colorectal tumour subtype. | 21587258 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | Methylation of Wnt5a is associated with distinct tumour subtypes, strengthening the evidence of an epigenetic-mediated Wnt bias in CRC. | 21587258 |
| Multiple Myeloma | Epigenetic Alterations | MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival. | 21592325 |
| Malignant Neoplasms | Epigenetic Alterations | A comparison of these microRNAs with those aberrantly expressed in other B-cell and T-cell malignancies revealed a surprising degree of similarity (~40%) suggesting the existence of a common lymphoma microRNA signature. | 21592325 |
| Malignant Neoplasms, Hematologic Neoplasms | Epigenetic Alterations | MicroRNAs are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many cancers including hematological malignancies. | 21592325 |
| Multiple Myeloma, Morular Metaplasia of the Endometrium | Epigenetic Alterations | However, the role of microRNAs in the pathogenesis of multiple myeloma (MM) is only poorly understood. | 21592325 |
| Monoclonal Gammopathy of Undetermined Significance | Epigenetic Alterations | We identified 39 microRNAs associated with the pre-malignant condition MGUS. | 21592325 |
| Multiple Myeloma | Epigenetic Alterations | Additionally, we identified microRNAs associated with light chain only myeloma, as well as IgG and IgA-type MM. | 21592325 |
| Primary malignant neoplasm | Epigenetic Alterations | Thus, DNA methylation analysis is expected to be a new tool for cancer diagnosis. | 21594664 |
| Malignant neoplasm of urinary bladder, Primary malignant neoplasm | Epigenetic Alterations | Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine. | 21599969 |
| Arteriosclerosis, Cardiovascular Diseases | Epigenetic Alterations | SNPs in miRNA-processing genes may modify associations between ambient pollution and sICAM-1 and sVCAM-1, which are correlates of atherosclerosis and cardiovascular disease. | 21600003 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is a promising biomarker for cancer. | 21600201 |
| SF3B1 wt Allele | Epigenetic Alterations | The distributions of these 2 miRNA levels were bimodal in MDS patients, and these levels were significantly associated with their progression-free survival and overall survival (both P < .001 for let-7a; P < .001 and P = .001 for miR-16). | 21602527 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Circulating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndrome. | 21602527 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNAs (miRNAs) are potential biomarkers for cancer. | 21602527 |
| SF3B1 wt Allele | Epigenetic Alterations | Circulating levels of both miRNAs were similar among healthy controls but were significantly lower in MDS patients (P = .001 and P < .001, respectively). | 21602527 |
| melanoma | Epigenetic Alterations | Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma. | 21606880 |
| Neoplasms | Epigenetic Alterations | MicroRNA-146a downregulates NFkB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma. | 21610143 |
| SCYL1 gene | Epigenetic Alterations | We measured miRNA expression in NKTL tissues and cell lines, using real-time PCR, and analyzed its role in NKTL, using cell lines. | 21610143 |
| Carcinoma of lung | Epigenetic Alterations | We then tested this 15-gene set to identify the more useful DNA methylation changes in the serum of a limited number of lung cancer patients and controls. | 21610147 |
| Carcinoma of lung | Epigenetic Alterations | An epigenetic marker panel for detection of lung cancer using cell-free serum DNA. | 21610147 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer. | 21610322 |
| Carcinoma of lung | Epigenetic Alterations | In addition identifying patients with KEAP1 genetic and epigenetic abnormalities may contribute to disease progression prediction and response to therapy in lung cancer patients. | 21610322 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. | 21610323 |
| Renal Cell Carcinoma, Refractory Cytopenia of Childhood | Epigenetic Alterations | Here, we defined profiles of DNA methylation in primary renal cell carcinomas (RCC) and assessed the association of these profiles with the expression of genes required for the establishment and maintenance of epigenetic marks. | 21610323 |
| Nerve Degeneration, Huntington Disease | Epigenetic Alterations | These findings suggest that other genetic, epigenetic, and environmental factors play important roles in neurodegeneration in Huntingtons disease. | 21611979 |
| Primary malignant neoplasm | Epigenetic Alterations | Genome-wide alterations in DNA methylation are a common event in cancer. | 21615918 |
| Concomitant Medication Submission Domain | Epigenetic Alterations | Overall level of genomic DNA methylation was measured using bisulfite pyrosequencing at three CpG sites (CpG1, CpG2, CpG3) of the Long Interspersed Nucleotide Element-1 (LINE-1) sequences in short-term CM cultures from 42 stage IIIC patients. | 21615918 |
| Carcinoma of lung | Epigenetic Alterations | The microRNA (miRNA) miR-196a2 may play an important role in lung cancer development and survival by altering binding activity of target mRNA. | 21617338 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA miR-335 is crucial for the BRCA1 regulatory cascade in breast cancer development. | 21618216 |
| Breast Carcinoma | Epigenetic Alterations | Deregulation of the microRNA during breast cancer development and progression may thereby lead to an increased tumorigenic potential by inactivating crucial tumor-suppressive signals. | 21618216 |
| Cerebral Ischemia | Epigenetic Alterations | MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia. | 21622133 |
| Ischemia | Epigenetic Alterations | MicroRNA-210 (miR-210), a master and pleiotropic hypoxia-microRNA, plays multiple roles in brain ischemia. | 21622133 |
| Cerebrovascular accident | Epigenetic Alterations | Compared to healthy controls, blood miRNA-210 was significantly decreased in stroke patients (0.93 vs. 1.36; P=0.001), especially at 7 days (0.56 vs. 1.36; P=0.001) and 14 days of stroke onset (0.50 vs. 1.36; P=0.001). | 21622133 |
| Admitting diagnosis, MIRLET7F1 wt Allele | Epigenetic Alterations | miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens (all P < .05; t test). | 21622546 |
| Adenocarcinoma, Neoplasms, Admitting diagnosis, Squamous cell carcinoma, SERPINB3 wt Allele | Epigenetic Alterations | MicroRNAs (miRNAs) are small noncoding genes recently reported as useful in differentiating squamous cell carcinoma (SCC) from adenocarcinoma (AD) in resected tumor specimens. | 21622546 |
| Metastasis, Familial medullary thyroid carcinoma | Epigenetic Alterations | MicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis, and potential therapeutic targets. | 21622722 |
| Magnetic-Targeted Carriers, Primary malignant neoplasm | Epigenetic Alterations | In addition, microRNAs (miRNAs) have been shown to be important diagnostic and prognostic markers in cancer but have not been defined in MTC. | 21622722 |
| Magnetic-Targeted Carriers | Epigenetic Alterations | Our data indicate that miRNAs play a pivotal role in the biology of MTC and represent an important class of prognostic biomarkers and therapeutic targets warranting further investigation. | 21622722 |
| Carcinoma of larynx | Epigenetic Alterations | [DNA methylation and histone modification relate to RASSF1A gene deletion in laryngeal carcinoma tissues]. | 21624251 |
| Carcinoma of larynx | Epigenetic Alterations | Chromatin immunoprecipitation (ChIP), methylation specific polymerase chain reaction (MSP) and realtime quantitative reverse transcription polymerase chain reaction (realtime RT-PCR) were used to analyze RASSF1A gene promoter region histone H3 lysine 9 methylation, H3 lysine 4 methylation, H3 lysine 9 acetylation, DNA methylation, and RASSF1A gene expression in laryngeal carcinoma tissue of 50 cases. | 21624251 |
| Carcinoma of larynx | Epigenetic Alterations | DNA methylation rate of gene RASSF1A was 62% in 50 cases of laryngeal carcinoma, but no DNA methylation was found in normal control group, with a significant difference (kh(2) = 15.381, P < 0.05). | 21624251 |
| Metastasis | Epigenetic Alterations | DNA methylation had no correlation with age, gender, differentiation degree, T stage, pathological type and lymph node metastasis (P > 0.05). | 21624251 |
| Affection | Epigenetic Alterations | The affection of DNA methylation group was more than unmethylation group to expression of gene RASSF1A (t = -3.108, P < 0.01). | 21624251 |
| Carcinoma of larynx | Epigenetic Alterations | There was positive correlation between RASSF1A deletion and gene hypermethylation or between H3 lysine 9 methylation of RASSF1A gene promoter and DNA methylation in laryngeal carcinoma tissue(r = 0.816, P < 0.05), but there was negative correlation between H3 lysine 4 methylation of RASSF1A gene promoter and DNA methylation (r = -0.837, P < 0.05) and no correlation between H3 lysine 9 acetylation and DNA methylation (r = -0.383, P > 0.05). | 21624251 |
| Neoplasms | Epigenetic Alterations | Laryngeal tumor suppressor gene RASSF1A promoter methylation is a key factor down-regulating the gene expression, and histone modifications also plays an important role in tumor development. | 21624251 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | *Global histone modification levels (H3K4me1, H3K4me3, H4K20me1, H4K20me2, and H4K20me3) were lower in bladder cancer samples than in NU tissue *Global levels of H3K4me1, H4K20me1, H4K20me2 and H4K20me3 were decreasing from NU over NMIBC and MIBC to METS. | 21627749 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | *To determine the role of global histone methylation as a prognostic parameter in patients with bladder cancer. | 21627749 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | *Global histone methylation levels may help to identify patients with bladder cancer with poor prognosis after radical cystectomy. | 21627749 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer. | 21627863 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA profiling for the identification of cancers with unknown primary tissue-of-origin. | 21630269 |
| Malignant Neoplasms | Epigenetic Alterations | These results establish that FFPE samples can be used to reveal the tissue of origin of metastatic cancers by using microRNA expression profiling and suggest that the approach, if applied, could provide strong indications for CUPs, whose correct diagnosis is presently undefined. | 21630269 |
| Glioma, Neoplasms | Epigenetic Alterations | DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas. | 21631628 |
| Malignant Glioma | Epigenetic Alterations | Taken together, our findings demonstrate that both 5-CpG island hypermethylation and histone modifications contribute to the frequent and prognostically unfavorable transcriptional downregulation of RRP22 in malignant gliomas. | 21631628 |
| Toxicity aspects, Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | Given that dysregulation of hepatic microRNA expression has been observed in NAFLD, we examined the role of miRNA in regulating PUMA expression during lipotoxicity. | 21633093 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | DNA hypermethylation is a common epigenetic abnormality in colorectal cancers (CRCs) and a promising class of CRC screening biomarkers. | 21636702 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. | 21637912 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Until now, there are no data published on the miRNA expression in head and neck cancers from Malaysia. | 21637912 |
| Primary malignant neoplasm | Epigenetic Alterations | Diverse studies on expression profiling of miRNAs have been performed and the data showed that some miRNAs are up-regulated or down-regulated in cancer. | 21637912 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | These miRNAs may contribute in a simple profiling strategy to identify individuals at higher risk of developing head and neck cancers, thus helping in the elucidation of the molecular mechanisms involved in head and neck cancer pathogenesis. | 21637912 |
| Hypoxia, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In summary, neuroglobin and myoglobin overexpression in NSCLC is associated with histological subtype, hypoxia and, in case of neuroglobin - epigenetic regulation. | 21640426 |
| Malignant neoplasm of breast | Epigenetic Alterations | We broadly profiled DNA methylation in breast cancers (n = 351) and benign parenchyma (n = 47) for correspondence with disease phenotype, using FFPE diagnostic surgical pathology specimens. | 21641572 |
| Malignant Neoplasms | Epigenetic Alterations | However, genetic and epigenetic alterations of SIP1 have not been fully elucidated in cancers. | 21645397 |
| Hollings Cancer Center | Epigenetic Alterations | Epigenetic mechanisms contribute significantly to the downregulation of SIP1 expression in HCC. | 21645397 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNA) are noncoding regulatory RNAs involved in initiation and progression of human cancers. | 21652542 |
| Primary malignant neoplasm | Epigenetic Alterations | In 10 resected PDAC samples, miR-10b was the most frequently and consistently overexpressed miRNA among characterized miRNAs, exhibiting a four-fold increase in the cancer cells (P = 0.012). | 21652542 |
| Carcinoma of lung, Lung Neoplasms | Epigenetic Alterations | In a comprehensive evaluation of EBV miRNA, DNA, RNA, and protein in lung cancer, we found little evidence of EBV in lung tumour tissue. | 21654679 |
| Carcinoma of lung | Epigenetic Alterations | Epstein-Barr virus microRNAs and lung cancer. | 21654679 |
| Neoplasms | Epigenetic Alterations | We tested for EBV DNA, RNA, and protein in tumour tissue from six cases with and six cases without strong qPCR-based evidence of EBV miRNAs. | 21654679 |
| Neoplasms | Epigenetic Alterations | Although qPCR provided substantial evidence of EBV miRNAs in 7 out of 48 cases, only 1 of these 7 cases had detectable EBV DNA in tumour tissue. | 21654679 |
| Stage I Esophageal Squamous Cell Carcinoma AJCC v7 | Epigenetic Alterations | The oncogenetic role of microRNA-31 as a potential biomarker in oesophageal squamous cell carcinoma. | 21658006 |
| Malignant Neoplasms | Epigenetic Alterations | miR-31 (microRNA-31) is frequently altered in numerous cancers. | 21658006 |
| Pancreatic carcinoma | Epigenetic Alterations | Our study suggests that the mismatch repair genes play an important role in pancreatic cancer carcinogenesis and progression through epigenetic modification, and it may be regarded as a potential target for the management of pancreatic cancer. | 21660619 |
| Multiple Myeloma | Epigenetic Alterations | miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. | 21664042 |
| Neoplasms | Epigenetic Alterations | The deregulation of miRNAs expression contributes to tumorigenesis by modulating oncogenic and tumor suppressor signaling pathways. | 21664042 |
| Multiple Myeloma | Epigenetic Alterations | These results suggest the Myc-inducible miR-17-92 cluster miRNAs contribute to tumorigenesis and poor prognosis in multiple myeloma. | 21664042 |
| Neoplasms | Epigenetic Alterations | DNA methylation analyses of mir-345 showed high methylation levels in tumor versus normal tissues. | 21665895 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer. | 21665895 |
| Clinical Coordinator | Epigenetic Alterations | Here, we investigated CpG island promoter hypermethylation as a potential mechanism underlying miRNA disruption and identifed methylation-sensitive miRNAs that might repress CRC development. | 21665895 |
| Clinical Coordinator | Epigenetic Alterations | The candidate miRNA was transfected into CRC cells and growth-suppressive mechanisms were explored. | 21665895 |
| Clinical Coordinator | Epigenetic Alterations | These results suggested as a methylation-sensitive miRNA in CRC, mir-345 may play an important role of antineoplastic as a growth inhibitor in the development of CRC. | 21665895 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have been found deregulated in human colorectal cancer (CRC), and some of them may function as tumor suppressor genes. | 21665895 |
| Neoplasms | Epigenetic Alterations | Initial screening established a profile of aberrantly expressed miRNAs in tumors. | 21666718 |
| Malignant tumor of colon, Neoplasms | Epigenetic Alterations | Transcription and external cell signaling factors are altered as covariates to COX-2 expression in colon cancer tissue, but DNA methylation of the COX-2 promoter region was not a significant factor behind COX-2 expression in tumor and normal colon tissue. | 21668942 |
| Carcinogenesis | Epigenetic Alterations | In a network analysis, chromatin modifications were linked to 11 significantly modulated histone genes, pointing towards a possible epigenetic mechanism that may be relevant in comprehending NOC-induced carcinogenesis. | 21669488 |
| Colorectal Carcinoma | Epigenetic Alterations | [DNA methylation of ZIC1 and KLOTHO gene promoters in colorectal carcinomas and its clinicopathological significance]. | 21671493 |
| Colorectal Carcinoma | Epigenetic Alterations | To determine DNA methylation status of ZIC1 and KLOTHO gene in colorectal carcinomas and its relationship with clinicopathological features of patients. | 21671493 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | Detection of circulating miRNAs might provide new complementary tumour markers for ESCC. | 21673684 |
| Small cell carcinoma of lung | Epigenetic Alterations | Genetic variation in an miRNA-1827 binding site in MYCL1 alters susceptibility to small-cell lung cancer. | 21676885 |
| Primary malignant neoplasm | Epigenetic Alterations | Genetic variations in microRNAs (miRNA) that affect control of their target genes may alter individual susceptibilities to cancer. | 21676885 |
| Small cell carcinoma of lung | Epigenetic Alterations | Our findings define a 3-UTR SNP in the human L-MYC oncogene that may increase susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827. | 21676885 |
| Injury of kidney | Epigenetic Alterations | Renal kallikrein excretion and epigenetics in human acute kidney injury: expression, mechanisms and consequences. | 21679467 |
| Kidney Failure, Acute | Epigenetic Alterations | Therefore we first examined KLK1 renal excretion in human AKI, and then probed potential endocrine and epigenetic mechanisms for its alterations. | 21679467 |
| Kidney Failure, Acute | Epigenetic Alterations | Epigenetic changes at KLK1 may also play a role in early changes of KLK1 expression and thus AKI susceptibility or recovery. | 21679467 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Bladder cancer cells illustrate major disruptions in their DNA methylation patterns as compared with normal ones. | 21680534 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Authors aimed to identify epigenetic molecular markers in urine for early detection of bladder cancer. | 21680534 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | We tested the epigenetic silencing hypothesis and evaluated the biological influence of KISS1 methylation on its expression and clinical relevance in bladder cancer. | 21683672 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | KISS1 hypermethylation was identified in bladder cancer, providing a potential mechanistic explanation (epigenetic silencing) for the observed loss of KISS1 in uroepithelial malignancies. | 21683672 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are a recently discovered class of small non-coding RNAs that regulate gene expression and may contribute to the development and progression of many cancers. | 21684154 |
| Endocrine System Diseases | Epigenetic Alterations | The etiopathogenesis of the trait is a matter of debate and ranges from genetic predisposition to epigenetic, while endocrine disturbances, aging, and dietary factors are also listed among the causes. | 21684729 |
| Psoriasis | Epigenetic Alterations | Considering that two main characteristics of psoriasis are keratinocytes hyperproliferation and abnormal skin differentiation, we hypothesized that aberrant microRNA expression contributes to the psoriatic phenotype. | 21687694 |
| MIRN99a microRNA, human | Epigenetic Alterations | MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R. | 21687694 |
| MIRN99a microRNA, human | Epigenetic Alterations | Fourteen differentially expressed microRNAs were identified, including hsa-miR-99a, hsa-miR-150, hsa-miR-423 and hsa-miR-197. | 21687694 |
| Carcinogenesis | Epigenetic Alterations | These findings suggest that both processes stem from the same epigenetic and genetic events occurring at an early stage in colon carcinogenesis in AAs. | 21687703 |
| Cytomegalovirus Infections, Hypertensive disease | Epigenetic Alterations | Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection. | 21690488 |
| Cytomegalovirus Infections, Hypertensive disease, Hypertensive (finding) | Epigenetic Alterations | We report for the first time a circulating miRNA profile for hypertensive patients and demonstrate a novel link between HCMV infection and essential hypertension. | 21690488 |
| Hypertensive disease | Epigenetic Alterations | However, little is known about the roles of miRNAs in essential hypertension. | 21690488 |
| Malignant Neoplasms | Epigenetic Alterations | Different microRNAs have been shown to have oncogenic and tumor-suppressive functions in human cancers. | 21692045 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is a fundamental epigenetic event associated with physiologic and pathologic conditions, including cancer. | 21692051 |
| Neoplasms | Epigenetic Alterations | The authors analyzed 16 matched normal and tumor tissues for aberrant DNA methylation using the methylated CpG island amplification and microarray method and the pyrosequencing technique. | 21692051 |
| Malignant Neoplasms | Epigenetic Alterations | It has been suggested that the presence of single-nucleotide polymorphisms in precursor miRNAs (pre-miRNAs) can alter miRNA processing, expression, and/or binding to target mRNA and represent another type of genetic variability that can contribute to the development of human cancers. | 21692953 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are an abundant class of small nonprotein-coding RNAs with posttranscriptional regulatory functions as tumour suppressors and oncogenes. | 21692953 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant expression and structural alteration of miRNAs are thought to participate in tumourigenesis and cancer development. | 21692953 |
| Prostate Cancer Pathway | Epigenetic Alterations | Absolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing. | 21694441 |
| Prostate Cancer Pathway, Carcinogenesis, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Aberrant DNA methylation plays a pivotal role in carcinogenesis and its mapping is likely to provide biomarkers for improved diagnostic and risk assessment in prostate cancer (PCa). | 21694441 |
| Carcinoma of lung | Epigenetic Alterations | SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma. | 21694641 |
| Carcinoma of lung | Epigenetic Alterations | Recently, analysis of DNA methylation of the SHOX2 locus was shown to reliably identify lung cancer in bronchial aspirates of patients with disease. | 21694641 |
| Lung diseases | Epigenetic Alterations | DNA methylation of SHOX2 could be used as a biomarker to distinguish between malignant lung disease and controls at a sensitivity of 60% (95% confidence interval: 53-67%) and a specificity of 90% (95% confidence interval: 84-94%). | 21694641 |
| Carcinoma of lung, Lung diseases | Epigenetic Alterations | SHOX2 DNA methylation is a biomarker for detecting the presence of malignant lung disease in blood plasma from patients with lung cancer. | 21694641 |
| Hyperhomocysteinemia | Epigenetic Alterations | Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia. | 21697534 |
| Homocysteinemia | Epigenetic Alterations | However, the reduction in homocysteinemia and the increased availability of methyl compounds provided by vitamin supplementation may not be sufficient to affect genomic DNA methylation. | 21697534 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | We demonstrate a distinct and rapid increase in levels of cardiospecific miRNA in the circulation after myocardial infarction. | 21701171 |
| Necrosis | Epigenetic Alterations | Release of miRNAs correlated with cardiomyocyte necrosis markers, the ejection fraction, and the GFR, indicating a possible role for these molecules as biomarkers for the diagnosis of STEMI as well as the prediction of long-term complications. | 21701171 |
| Primary malignant neoplasm | Epigenetic Alterations | We focused on the functional significance of miR-1 and miR-133a in cancer cells and identification of the novel cancer networks regulated by these miRNAs in MSSCC. | 21701775 |
| Primary malignant neoplasm | Epigenetic Alterations | Restoration of downregulated miRNAs (miR-1 or miR-133a) in cancer cells revealed that both miRNAs significantly inhibited cancer cell proliferation and induced cell apoptosis. | 21701775 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2-deoxycytidine (5-aza-CdR) and determined the expressions of the 55 miRNAs. | 21702040 |
| Carcinoma of lung | Epigenetic Alterations | The DNA methylation of mir-34b can be used as a biomarker for an invasive phenotype of lung cancer. | 21702040 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer. | 21702040 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miRNA) expression is frequently altered in human cancers. | 21702040 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | To search for epigenetically silenced miRNAs in non-small-cell lung cancer (NSCLC), we mapped human miRNAs on autosomal chromosomes and selected 55 miRNAs in silico. | 21702040 |
| Primary malignant neoplasm | Epigenetic Alterations | Fourteen miRNAs were decreased in the cancer cell lines and were induced after 5-aza-CdR treatment. | 21702040 |
| SF3B1 wt Allele | Epigenetic Alterations | This study identifies microRNAs (miRNA) and miRNA targets that might represent diagnostic markers for MDS. | 21703983 |
| SF3B1 wt Allele | Epigenetic Alterations | A discovery set of 20 frozen bone marrow mononuclear cell samples (10 MDS, 10 controls) was profiled on a custom Agilent miRNA microarray. | 21703983 |
| SF3B1 wt Allele | Epigenetic Alterations | Target prediction identified potential targets of miRNA regulation that correspond to many of the genes that characterize MDS. | 21703983 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Diagnostic microRNAs in myelodysplastic syndrome. | 21703983 |
| SF3B1 wt Allele | Epigenetic Alterations | Classifier miRNAs were validated in a separate set of 49 paraffin-embedded particle preparations by real-time polymerase chain reaction (24 MDS, 25 controls). | 21703983 |
| SF3B1 wt Allele | Epigenetic Alterations | Our data utilize both discovery and validation sets and two complementary platforms to identify miRNAs associated with MDS. | 21703983 |
| Prostate Cancer Pathway | Epigenetic Alterations | We found that global DNA methylation was low in most prostate cancer compared with benign regions from the same patients sections. | 21704537 |
| Hepatitis B, Malignant neoplasm of liver | Epigenetic Alterations | Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer. | 21706058 |
| Colorectal Carcinoma, Carcinogenesis, Adenocarcinoma | Epigenetic Alterations | Epigenetic silencing of the DNA mismatch repair genes has been poorly described in colorectal carcinomas showing the classic adenoma-carcinoma pathway of carcinogenesis. | 21706233 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour. | 21708825 |
| Gastrointestinal Stromal Sarcoma | Epigenetic Alterations | Additionally, genome-wide DNA methylation profiles were compared between small, malignant-prone, and malignant GISTs using methylated GpG island amplification microarrays (MCAM) in a training set (n=40). | 21708825 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Our results suggest that GIST is not, in epigenetic terms, a uniform disease and that DNA methylation in a set of genes is associated with aggressive clinical behavior and unfavorable prognosis. | 21708825 |
| Aggressive behavior, Gastrointestinal Stromal Tumors | Epigenetic Alterations | The majority of gastrointestinal stromal tumors (GISTs) have KIT mutations; however, epigenetic abnormalities that could conceivably potentiate the aggressiveness of GISTs are largely unidentified. | 21708825 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Our aim was to establish epigenetic profiles associated with the malignant transformation of GISTs. | 21708825 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic fingerprint in endometrial carcinogenesis: the hypothesis of a uterine field cancerization. | 21709441 |
| Malignant Neoplasms | Epigenetic Alterations | Non-endometrioid cancers showed very low levels of epigenetic methylations, but strong P53 protein positivity. | 21709441 |
| Endometrial | Epigenetic Alterations | Finally, this study assessed that the use of an epigenetic fingerprint may improve the current diagnostic tools for a better clinical management of endometrial lesions. | 21709441 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation is an important mechanism of gene silencing in human malignancies. | 21709715 |
| Psoriasis vulgaris | Epigenetic Alterations | microRNA-mediated keratinocyte hyperproliferation in psoriasis vulgaris. | 21711342 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | miRNA and mRNA were isolated from surgical lung biopsies from IPF patients with a clinically documented rapid or slow course of disease over the first year after diagnosis. | 21712985 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | A quantitative PCR miRNA array containing 88 of the most abundant miRNA in the human genome was used to profile lung biopsies from 9 patients with rapidly progressing IPF, 6 patients with slowly progressing IPF, and 10 normal lung biopsies. | 21712985 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Five miRNA (miR-302c, miR-423-5p, miR-210, miR-376c, and miR-185) were significantly increased in rapid compared with slow IPF lung biopsies. | 21712985 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | These findings suggest that the development and/or clinical progression of IPF might be the consequence of aberrant miRNA processing. | 21712985 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis. | 21712985 |
| Neoplasms | Epigenetic Alterations | A variety of germline and somatic, genetic and epigenetic alterations at 9p21.3, which encode CDKN2A/CDKN2B tumor suppressor genes, have been isolatedly reported to be associated with GBM risk and prognosis. | 21713760 |
| Ovarian Serous Adenocarcinoma, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours. | 21720365 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | Analyses delineated four ovarian cancer transcriptional subtypes, three microRNA subtypes, four promoter methylation subtypes and a transcriptional signature associated with survival duration, and shed new light on the impact that tumours with BRCA1/2 (BRCA1 or BRCA2) and CCNE1 aberrations have on survival. | 21720365 |
| Neoplasms | Epigenetic Alterations | Tumor (cellular) and serum microRNA copy numbers from the same 15 patients were correlated. | 21720996 |
| Neoplasms | Epigenetic Alterations | Further investigation of potential EBV microRNA target genes revealed inhibition of tumor suppressor genes (eg, PTEN) and extensive deregulation of several pathways frequently involved in NPC (eg, Wnt signaling). | 21720996 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs. | 21720996 |
| Nasopharyngeal carcinoma, Neoplasms | Epigenetic Alterations | Epstein-Barr virus (EBV) microRNAs are abundant in nasopharyngeal carcinoma (NPC) tumors. | 21720996 |
| Neoplasms | Epigenetic Alterations | Twenty-nine of 39 EBV microRNAs were significantly up-regulated in tumor versus their nontumor biopsies (P < .05). | 21720996 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Prognostic significance of serum miRNA-21 expression in human non-small cell lung cancer. | 21721011 |
| Neoplasms | Epigenetic Alterations | Deregulation of microRNAs (miRNAs) plays important roles in tumor progression. | 21721011 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Dysregulated miRNAs in NSCLC serum were identified by microarray. | 21721011 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | Invasion front-specific expression and prognostic significance of microRNA in colorectal liver metastases. | 21722265 |
| Cell Invasion, Neoplasms | Epigenetic Alterations | By comparing samples from the liver invasion front with samples from pure liver parenchyma, the tumor invasion front and the tumor center, 13 miRNA were downregulated. | 21722265 |
| Secondary malignant neoplasm of liver, Neoplasms | Epigenetic Alterations | In conclusion, the present study suggests that invasion front-specific downregulation of miRNA in colorectal liver metastases plays a pivotal role in tumor progression. | 21722265 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia. | 21724256 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | The results suggested that the epigenetic regulation of SPARC expression in tumor cells versus stromal cells of CRC is significantly different. | 21725199 |
| Serous Cystadenocarcinoma, Endometrial Endometrioid Adenocarcinoma | Epigenetic Alterations | microRNA expression profiling of endometrial endometrioid adenocarcinomas and serous adenocarcinomas reveals profiles containing shared, unique and differentiating groups of microRNAs. | 21725615 |
| Endometrial adenocarcinoma | Epigenetic Alterations | Quantitative miRNA profiling of endometrial adenocarcinomas revealed four overlapping groups of significantly overexpressed and underexpressed miRNAs. | 21725615 |
| Endometrial Carcinoma | Epigenetic Alterations | These validated and potential miRNA target lists were filtered using published lists of genes displaying significant overexpression or underexpression in endometrial cancers compared to benign endometrium. | 21725615 |
| Malignant Neoplasms | Epigenetic Alterations | microRNAs (miRNAs) control a multitude of pathways in human cancers. | 21725615 |
| Neoplasms | Epigenetic Alterations | Differential expression of miRNAs among different histological types of tumors within the same type of tissue offers insight into the mechanism of pathogenesis and may help to direct treatment to improve prognosis. | 21725615 |
| Adenocarcinoma, Endometrioid, Adenocarcinoma, Serous Cystadenocarcinoma | Epigenetic Alterations | The first group was composed of 20 miRNAs significantly dysregulated in both adenocarcinoma types compared with benign endometrium, two groups were composed of miRNAs significantly dysregulated in either endometrioid adenocarcinomas or in serous adenocarcinomas compared with benign endometrium, and the fourth group was composed of 17 miRNAs that significantly distinguished between endometrioid adenocarcinomas and serous adenocarcinomas themselves. | 21725615 |
| Endometrioid tumor, Neoplasms | Epigenetic Alterations | Validation of the expression levels of the selected miRNAs was carried out in a second panel composed of ten endometrioid and five serous tumors. | 21725615 |
| Malignant Neoplasms, Endometrial Carcinoma | Epigenetic Alterations | Our results revealed a number of dysregulated miRNAs that are commonly found in endometrial (and other) cancers as well as several dysregulated miRNAs not previously identified in endometrial cancers. | 21725615 |
| Small cell carcinoma of lung | Epigenetic Alterations | MicroRNA expression and clinical outcome of small cell lung cancer. | 21731696 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | miR-34a is known as a p53 regulated tumor suppressor microRNA in many cancer types. | 21731696 |
| Small cell carcinoma of lung | Epigenetic Alterations | The role of microRNAs in small-cell lung carcinoma (SCLC) is largely unknown. | 21731696 |
| Small cell carcinoma of lung | Epigenetic Alterations | The expression of the 7 microRNAs was unrelated to SCLC patients clinical characteristics and was neither prognostic in term of overall survival or progression-free survival nor predictive of treatment response. | 21731696 |
| Inflammation, Supranuclear paralysis | Epigenetic Alterations | Although little is known about the etiology of progressive supranuclear palsy (PSP), genetic and epigenetic factors, oxidative injury and inflammation are thought to contribute to its development and/or progression. | 21741294 |
| Neoplasms, Malignant neoplasm of gastrointestinal tract | Epigenetic Alterations | Prognostic impact of disseminated tumor cells and microRNA-17-92 cluster deregulation in gastrointestinal cancer. | 21743960 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNA) play key roles in cellular processes implicated in cancer. | 21743960 |
| Neoplasms | Epigenetic Alterations | miRNAs were isolated from formalin-fixed, paraffin-embedded tumors. | 21743960 |
| Carcinogenesis | Epigenetic Alterations | Single nucleotide polymorphisms (SNPs) in miRNAs may contribute to carcinogenesis by altering expression of miRNAs and their targets. | 21744077 |
| Carcinoma of lung | Epigenetic Alterations | A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer. | 21744498 |
| Non-Small Cell Lung Carcinoma, ABCB1 wt Allele | Epigenetic Alterations | We developed a test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of asymptomatic high-risk individuals with 80% accuracy. | 21744498 |
| Neoplasms | Epigenetic Alterations | The DNA methylation inhibitor, 5-aza-2-deoxycytidine, activated several of the genes that are demethylated and induced in tumors, supporting a causal role for demethylation in activation of these genes. | 21747116 |
| Malignant Neoplasms | Epigenetic Alterations | Recently discovered microRNAs (miRNAs), small noncoding RNA molecules, play a crucial role in modulating gene expression networks and are directly involved in the progression of a number of human cancers. | 21748820 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In this study, we analyzed the expression profile of 858 miRNAs in 38 Estonian nonsmall cell lung cancer (NSCLC) samples (Stage I and II) and 27 adjacent nontumorous tissue samples using Illumina miRNA arrays. | 21748820 |
| Neoplasms | Epigenetic Alterations | We found that 39 miRNAs were up-regulated and 33 down-regulated significantly in tumors compared with normal lung tissue. | 21748820 |
| Liver carcinoma | Epigenetic Alterations | Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. | 21749846 |
| Primary malignant neoplasm | Epigenetic Alterations | Several groups have reported the significance of circulating microRNA as a biochemical marker of cancer. | 21749846 |
| Liver carcinoma | Epigenetic Alterations | To our knowledge, however, there are no reports on the significance of circulating microRNA in hepatocellular carcinoma. | 21749846 |
| Liver carcinoma, Hepatitis, Chronic | Epigenetic Alterations | Plasma microRNA-21 was also compared in other groups of: 126 patients with hepatocellular carcinoma, 30 patients with chronic hepatitis, and 50 healthy volunteers. | 21749846 |
| Liver carcinoma, Hepatitis, Chronic | Epigenetic Alterations | The power of microRNA-21 in differentiating hepatocellular carcinoma from chronic hepatitis or from healthy volunteers was compared to that of a-fetoprotein. | 21749846 |
| Liver carcinoma, Hepatitis, Chronic | Epigenetic Alterations | Plasma microRNA-21 level in the 126 patients with hepatocellular carcinoma was significantly higher than in patients with chronic hepatitis and healthy volunteers (p<0.0001, p<0.0001, respectively). | 21749846 |
| Liver carcinoma | Epigenetic Alterations | Plasma microRNA-21 level is a promising biochemical marker for hepatocellular carcinoma. | 21749846 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Furthermore, we demonstrated for the first time that an aberrant epigenetic pattern involving DNA methylation, H3 and H4 acetylation, and trimethylation of histone H3 lysine 4 and histone H3 lysine 27 might play a role in the transcriptional regulation of EVI1 in acute myeloid leukemia. | 21750091 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia. | 21750091 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | We analyzed the prevalence and prognostic impact of EVI1 over-expression in a series of 476 patients with acute myeloid leukemia, and investigated the epigenetic modifications of the EVI1 locus which could be involved in the transcriptional regulation of this gene. | 21750091 |
| Carcinogenesis | Epigenetic Alterations | We carried out a global molecular analysis including assessment of ERCC1 expression levels by using both immunohistochemistry (IHC) and quantitative reverse transcriptase PCR (qRT-PCR), genomic instability, global gene and miRNA expression, and sequencing of selected key genes involved in lung carcinogenesis. | 21750204 |
| Neoplasms | Epigenetic Alterations | The miRNA expression analysis identified miR-375 as significantly underexpressed in ERCC1-positive tumors. | 21750204 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Neoplasms | Epigenetic Alterations | Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). | 21753766 |
| Hypopharyngeal Squamous Cell Carcinoma, Primary malignant neoplasm, Maxillary Sinus Squamous Cell Carcinoma, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Our microRNA (miRNA) expression signatures of hypopharyngeal squamous cell carcinoma, maxillary sinus squamous cell carcinoma and esophageal squamous cell carcinoma revealed that miR-375 was significantly reduced in cancer tissues compared with normal epithelium. | 21753766 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The identification of novel tumor suppressive miRNA and its regulated cancer pathways could provide new insights into potential molecular mechanisms of HNSCC oncogenesis. | 21753766 |
| Rheumatoid Arthritis | Epigenetic Alterations | DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts. | 21753787 |
| Breast Carcinoma | Epigenetic Alterations | Distinct expressions of microRNAs that directly target estrogen receptor a in human breast cancer. | 21755340 |
| Breast Carcinoma | Epigenetic Alterations | Recently, several microRNAs (miRNAs) that directly target ERa have been identified, and we previously demonstrated that miR-206 expression was downregulated in ERa-positive human breast cancer. | 21755340 |
| Neoplasms | Epigenetic Alterations | Surprisingly, the expression levels of miR-193b and miR-221 were significantly lower in ERa-negative than in ERa-positive tumors (P = 0.0015 and P = 0.0045, respectively), and the levels of these miRNAs gradually increased as ERa protein expression increased. | 21755340 |
| Breast Carcinoma | Epigenetic Alterations | Our results suggest that miRNAs that directly target ERa have distinct roles in not only regulating ERa but also regulating other target genes in human breast cancer. | 21755340 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Copy number changes and DNA methylation alterations are good indicators of carcinogenesis and cancer prognosis. | 21757291 |
| Ductal Breast Carcinoma, Pancreatic Cyst | Epigenetic Alterations | Elevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma. | 21757972 |
| Pancreatic carcinoma | Epigenetic Alterations | Deregulated microRNA (miRNAs) expression is widespread in pancreatic cancer. | 21757972 |
| Pancreatic Cyst | Epigenetic Alterations | We assessed whether aberrant miRNAs in pancreatic cyst fluid could be used as potential biomarkers for cystic precursor lesions of pancreatic cancer. | 21757972 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia. | 21760961 |
| Myeloproliferative disease | Epigenetic Alterations | Five genes were identified by DNA methylation screening in the K562 cell line and 3 genes in patients with myeloproliferative neoplasms. | 21760961 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | We conclude that aberrant DNA methylation is associated with CML progression and that DNA methylation could be a marker associated with imatinib resistance. | 21760961 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Finally, DNA methylation of PDLIM4 may help identify a subset of CML patients that would benefit from treatment with Src/Abl inhibitors. | 21760961 |
| Adamantinous Craniopharyngioma | Epigenetic Alterations | CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas. | 21761366 |
| Adult Craniopharyngioma | Epigenetic Alterations | Our data suggest the potential involvement of the deregulation of miRNA expression in the craniopharyngioma pathogenesis and outcome and also that the miRNA could modulate the Wnt signaling pathway in craniopharyngioma tumorigenesis. | 21761366 |
| Adult Craniopharyngioma, Pituitary Gland, Anterior | Epigenetic Alterations | Genes involved in formation/development of the adenohypophysis, CTNNB1 gene, and microRNAs might be implicated in the craniopharyngioma pathogenesis. | 21761366 |
| 22q11.2 | Epigenetic Alterations | Possible explanations include modification of the effect of TBX1 by genes outside of the 22q11.2 region that may further influence the formation of the palate or heart, or the presence of epigenetic factors that may effect genes within the deleted region, modifying genes elsewhere, or polymorphisms on the normal copy of chromosome 22. | 21763005 |
| Prostate Cancer Pathway | Epigenetic Alterations | Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer. | 21765474 |
| Malignant Neoplasms | Epigenetic Alterations | It is becoming increasingly evident that small non-coding RNA (ncRNA) species are associated with the development and progression of this malignancy. | 21765474 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our findings provide miRNA expression signatures that may serve as an accurate tool for the diagnosis and prognosis of PCa. | 21765474 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | miRNAs can predict prostate cancer biochemical relapse and are involved in tumor progression. | 21769427 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Literature search shows that many of these miRNAs have an established prognostic significance in other cancers and can be actively involved in tumor progression. | 21769427 |
| Neoplasms | Epigenetic Alterations | Target prediction analysis showed that predicted targets of these miRNAs could be involved in biological processes and pathways that enhance tumor progression. | 21769427 |
| Prostate Cancer Pathway | Epigenetic Alterations | miRNAs can be reliable predictive markers for biochemical relapse of prostate cancer at the time of radical prostatectomy. | 21769427 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | The pathogenesis of colorectal carcinoma (CRC) is a complex process that involves the recruitment of both genetic and epigenetic mechanisms. | 21769619 |
| Cutaneous Melanoma, melanoma | Epigenetic Alterations | In this study, we combined quantitative DNA methylation analysis in patient biopsies and in their derived cell lines to demonstrate that TCF21 expression is downregulated in metastatic melanoma by promoter hypermethylation and TCF21 promoter DNA methylation is correlated with decreased survival in metastatic skin melanoma patients. | 21771727 |
| Metastasis, melanoma | Epigenetic Alterations | Epigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma. | 21771727 |
| Aggressive behavior, melanoma | Epigenetic Alterations | These data suggest that epigenetic downregulation of TCF21 is functionally involved in melanoma progression and that it may serve as a biomarker for aggressive tumor behavior. | 21771727 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | However, none of the analyzed CpG sites in the three genes showed differences in DNA methylation in islets from donors with T2D compared with non-diabetic donors. | 21775499 |
| Inflammation | Epigenetic Alterations | We hypothesized that body mass may affect DNA methylation through increased estrogen and chronic inflammation. | 21775555 |
| Postmenopausal state | Epigenetic Alterations | It may be that the association of body fat composition and postmenopausal breast cancer is related to altered DNA methylation. | 21775555 |
| Mesothelioma, Neoplasms | Epigenetic Alterations | Using a case series of MPM patients from the International Mesothelioma Program at the Brigham and Womens hospital, we sought to determine whether epigenetic change at the MSLN gene in patient tumors is responsible for the poor sensitivity of SMRP. | 21775819 |
| Lichen Planus | Epigenetic Alterations | Changes in miRNA expression in sera and correlation to duration of disease in patients with multifocal mucosal lichen planus. | 21777290 |
| Lichen Planus | Epigenetic Alterations | Even if no specific LP-associated miRNA profile was found, data clearly indicate that miRNAs could play a role in the earlier phases of lichen planus. | 21777290 |
| Colorectal Cancer Pathway, Adenoma | Epigenetic Alterations | The presence of cancer-specific DNA methylation patterns in epithelial colorectal cells in human feces provides the prospect of a simple, non-invasive screening test for colorectal cancer and its precursor, the adenoma. | 21777459 |
| Colorectal Cancer Pathway, Adenoma | Epigenetic Alterations | Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas. | 21777459 |
| Colorectal Carcinoma, Adenoma | Epigenetic Alterations | The novel epigenetic marker panel shows very high sensitivity and specificity for both colorectal cancers and adenomas. | 21777459 |
| Thyroid Neoplasm, Neoplasms | Epigenetic Alterations | Can the microRNA signature distinguish between thyroid tumors of uncertain malignant potential and other well-differentiated tumors of the thyroid gland? | 21778212 |
| Follicular thyroid carcinoma, Thyroid Gland Follicular Adenoma, Follicular neoplasm, Papillary thyroid carcinoma | Epigenetic Alterations | We have analyzed the expression of microRNA (miRNA) in a training set of 42 WDT of different histological subtypes: seven follicular tumors of UMP (FT-UMP), six WDT-UMP, seven follicular thyroid adenomas (FTA), 11 conventional papillary thyroid carcinomas (C-PTC), five follicular variants of PTC (FV-PTC), and six follicular thyroid carcinomas (FTC), which led to the identification of about 40 deregulated miRNAs. | 21778212 |
| Lupus Erythematosus, Systemic, Antiphospholipid Syndrome | Epigenetic Alterations | Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome. | 21794077 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | Characterization of microRNAs expression profiling in one group of Chinese urothelial cell carcinoma identified by Solexa sequencing. | 21795071 |
| Primary malignant neoplasm | Epigenetic Alterations | In addition, transduction of cancer cell lines with DOK1 impaired their proliferation, consistent with the critical role of epigenetic silencing of DOK1 in the development and maintenance of malignant cells. | 21796618 |
| Primary malignant neoplasm | Epigenetic Alterations | Thus, hypermethylation of DOK1 is a potentially critical event in human carcinogenesis, and may be a potential cancer biomarker and an attractive target for epigenetic-based therapy. | 21796618 |
| Uterine Cervical Neoplasm | Epigenetic Alterations | DNA methylation markers, with high sensitivity and specificity are urgently needed to improve current population-based screening on (pre)malignant cervical neoplasia. | 21796628 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) play an important role in carcinogenesis through the regulation of their target genes. | 21799879 |
| Alzheimers Disease | Epigenetic Alterations | Epigenetic silencing of nucleolar rRNA genes in Alzheimers disease. | 21799908 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Previous studies have suggested that SLC5A8 might function as a tumor suppressor gene, whose silencing by epigenetic changes might contribute to carcinogenesis. | 21802122 |
| Primary central nervous system lymphoma | Epigenetic Alterations | Using paraffin-embedded biopsy specimens from 21 HIV-negative patients with newly diagnosed PCNSL (n = 11) and nDLBCL (n= 10), we measured the expression of 365 miRNA species by quantitative real-time PCR using low-density PCR arrays. | 21803762 |
| Primary central nervous system lymphoma | Epigenetic Alterations | We conclude that PCNSL exhibits a distinct pattern of miRNA expression compared with nDLBCL. | 21803762 |
| Lymphoma | Epigenetic Alterations | Differential micro-RNA expression in primary CNS and nodal diffuse large B-cell lymphomas. | 21803762 |
| Primary malignant neoplasm | Epigenetic Alterations | Micro-RNAs (miRNAs) have been associated with cancer development and progression. | 21803762 |
| Primary central nervous system lymphoma | Epigenetic Alterations | We found that 18 miRNAs were differentially expressed: median expression levels of 13 miRNAs were 2.1-13.1 times higher in PCNSL, and median expression levels of 5 miRNAs were 2.6-3.3 times higher in nDLBCL. | 21803762 |
| MIR20A gene, Primary central nervous system lymphoma | Epigenetic Alterations | MiRNAs upregulated in PCNSL were associated with the Myc pathway (miR-17-5p, miR-20a, miR-9), with blocking of terminal B-cell differentiation (miR-9, miR-30b/c), or with upregulation by inflammatory cytokines (miR-155). | 21803762 |
| Primary central nervous system lymphoma | Epigenetic Alterations | Putative tumor-suppressor miRNAs (miR-199a, miR-214, miR-193b, miR-145) were downregulated in PCNSL. | 21803762 |
| Primary central nervous system lymphoma | Epigenetic Alterations | There was no overlap of miRNAs dysregulated in PCNSL with those differentially expressed between immunohistologically defined germinal center B cell-like (GCB) and non-GCB types or, apart from miR-9, with miRNAs known to be overexpressed in human brain. | 21803762 |
| Cardiovascular Diseases | Epigenetic Alterations | MicroRNAs (miRNAs) are a novel class of small, non-coding RNAs that play a significant role in both inflammatory and cardiovascular diseases. | 21804579 |
| Primary malignant neoplasm | Epigenetic Alterations | The phosphatidylinositol-3-OH kinase (PI3K)-Akt pathway is activated in cancer by genetic or epigenetic events and efforts are under way to develop targeted therapies. | 21804599 |
| ovarian neoplasm | Epigenetic Alterations | This chapter will provide in-depth protocols to analyze epigenetic alterations in proprotein convertase gene expression using the PCSK6 gene in the context of human ovarian cancer as a model system. | 21805246 |
| Malignant Neoplasms | Epigenetic Alterations | It has been suggested that the presence of single nucleotide polymorphisms in precursor miRNAs (pre-miRNAs) can alter miRNA processing, expression, and/or binding to target mRNA and represent another type of genetic variability that can contribute to the susceptibility of human cancers. | 21807077 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant expression and structural alteration of miRNAs are considered to participate in tumorigenesis and cancer development. | 21807077 |
| Malignant Neoplasms, Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | To characterize the interactions of non-small cell lung cancer (NSCLC) tumors with the immune system at the level of mRNA and microRNA (miRNA) expression and to define expression signatures that characterize the presence of a malignant tumor versus a nonmalignant nodule. | 21807633 |
| Neoplasms | Epigenetic Alterations | A tumor presence in the lung influences mRNA and miRNA expression in PBMC and this influence is reversed by tumor removal. | 21807633 |
| Neoplasms | Epigenetic Alterations | Additional important regulators included five miRNAs expressed at significantly higher levels before tumor removal. | 21807633 |
| Loss, Supranuclear paralysis | Epigenetic Alterations | MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy. | 21807765 |
| Tauopathies | Epigenetic Alterations | Taken together, these results suggest that changes in the miR-132/PTBP2 pathway could contribute to the abnormal splicing of tau exon 10 in the brain, and sheds light into the potential role played by miRNAs in a subset of tauopathies. | 21807765 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Testicular germ cell tumors (TGCTs) have a unique epigenetic profile distinct from that of other types of cancer. | 21809391 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Several miRNAs have been found to be inappropriately regulated by DNA methylation in patients with acute lymphoblastic leukaemia (ALL). | 21810092 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Deregulation of FGFR1 and CDK6 oncogenic pathways in acute lymphoblastic leukaemia harbouring epigenetic modifications of the MIR9 family. | 21810092 |
| Neoplasms | Epigenetic Alterations | The role of epigenetic mechanisms in the regulation of microRNAs (miRNAs) with a tumour-suppressor function in human neoplasms has recently been established. | 21810092 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Epigenetic downregulation of MIR9 induced upregulation of its targets, FGFR1 and CDK6, while treatment of ALL cells with FGFR1 (PD-173074) and CDK6 (PD-0332991) inhibitors induced a decrease in cell proliferation and an increase in apoptosis of ALL cells. | 21810092 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Our results indicate that the MIR9 family is involved in the pathogenesis and clinical behaviour of ALL and provide the basis for new therapeutic strategies in the treatment of ALL, targeting the epigenetic regulation of miRNAs and/or the FGFR1 or CDK6-RB pathway directly. | 21810092 |
| Prostate Cancer Pathway | Epigenetic Alterations | NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene. | 21810217 |
| Tongue Diseases | Epigenetic Alterations | On an individual gene level, significant enrichment of transcripts early in dengue disease were chemokines CCL2 (MCP-1), CCL8 (MCP-2), CXCL10 (IP-10) and CCL3 (MIP-1a), antimicrobial peptide b-defensin 1 (DEFB1), desmosome/intermediate junction component plakoglobin (JUP) and a microRNA which may negatively regulate pro-inflammatory cytokines in dengue infected peripheral blood cells, mIR-147 (NMES1). | 21810247 |
| ovarian neoplasm | Epigenetic Alterations | Evidence for the complexity of microRNA-mediated regulation in ovarian cancer: a systems approach. | 21811625 |
| Primary malignant neoplasm | Epigenetic Alterations | Our findings underscore the complexities of miRNA-mediated regulation in vivo and the necessity of understanding the basis of these complexities in cancer cells before the therapeutic potential of miRNAs can be fully realized. | 21811625 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases including cancer. | 21811625 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | However, the potential clinical utility of miRNAs in cancer therapy rests heavily upon our ability to understand and accurately predict the consequences of fluctuations in levels of miRNAs within the context of complex tumor cells. | 21811625 |
| Plaque (lesion) | Epigenetic Alterations | A unique microRNA signature associated with plaque instability in humans. | 21817153 |
| Medical Device Material Rupture, Plaque, Atherosclerotic, atherosclerotic | Epigenetic Alterations | These results are the first to report alterations in the expression of specific miRNAs in human atherosclerotic plaques and suggest that miRNAs may have an important role in regulating the evolution of atherosclerotic plaque toward instability and rupture. | 21817153 |
| Primary malignant neoplasm | Epigenetic Alterations | The choice of specific regions in the CpG island is a critical step in determining the functional role and prognostic value of DNA methylation in cancer cells. | 21818286 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas. | 21818286 |
| Squamous cell carcinoma, SERPINB3 wt Allele, Molecular Abnormality | Epigenetic Alterations | Recent studies indicate various molecular abnormalities in oral squamous cell carcinomas (OSCC), including DNA methylation of tumor-associated genes. | 21819494 |
| Colorectal Cancer Pathway, Colorectal Neoplasms | Epigenetic Alterations | Overall, this study identifies for the first time the relevant metallothionein isoforms for colorectal cancer progression, supports the concept that their loss is associated with worse prognosis, and suggests 2 mechanisms for epigenetic repression of metallothionein expression in colorectal tumors. | 21820154 |
| atherosclerotic | Epigenetic Alterations | The microRNA expression profile differs significantly between atherosclerotic plaques and control arteries. | 21820659 |
| Plaque, Atherosclerotic, Cardiovascular Diseases | Epigenetic Alterations | Interfering with the miRNA expression in the artery wall is a potential way to affect atherosclerotic plaque and cardiovascular disease development. | 21820659 |
| atherosclerotic | Epigenetic Alterations | Ten miRNAs were found to be differently expressed in atherosclerotic plaques when compared to controls (p<0.05). | 21820659 |
| Arteriosclerosis | Epigenetic Alterations | The most up-regulated miRNAs are involved in processes known to be connected to atherosclerosis. | 21820659 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic control of CDK2NA was observed in vitro in 11 cancer cell lines. | 21821326 |
| Thrombocytosis, Polycythemia Vera | Epigenetic Alterations | Epigenomic profiling in polycythaemia vera and essential thrombocythaemia shows low levels of aberrant DNA methylation. | 21821860 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation in promoters of tumor suppressor genes is an early and frequent event during prostate carcinogenesis. | 21822036 |
| CHOANAL ATRESIA, POSTERIOR, Primary malignant neoplasm | Epigenetic Alterations | Modern techniques allow a sensitive detection of DNA methylation biomarkers in bodily fluids from cancer patients offering a noninvasive tool for PCa monitoring. | 21822036 |
| Malignant tumor of colon | Epigenetic Alterations | There is significant difference of miRNA expression between colon caner and normal colonic mucosa. | 21826996 |
| Malignant tumor of colon, MicroRNA 105 | Epigenetic Alterations | The up-regulated miRNAs in colon cancer included has-miR-182, has-miR-17, hasmiR-106a, has-miR-93, has-miR-200c, has-miR-92a, has-let-7a, has-miR-20a (FDR value < 5%), while the downregulated miRNAs were has-miR-l195, has-miR-143, has-miR-145 (FDR value < 5%). | 21826996 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | RT-PCR and qPCR were used to detect miRNA expression in liver metastases by utilizing TaqMan(r) MicroRNA Reverse Transcription Kit and TaqMan(r) miRNA Assays. | 21827717 |
| Colorectal Cancer Pathway, DICER1 protein, human | Epigenetic Alterations | Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients. | 21827717 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | We also correlated the expression of Dicer mRNA to the miRNA expression of miR-141, miR-200a, miR-200b, mir-200c and miR-429 in liver metastases. | 21827717 |
| Leukemia, Myelomonocytic, Chronic | Epigenetic Alterations | Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. | 21828135 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma. | 21829728 |
| Glioma | Epigenetic Alterations | As a global DNA methylation marker, LINE-1 may be a promising marker in gliomas. | 21829728 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | DNA methylation changes correlate with Gleason score and tumor stage in prostate cancer. | 21830905 |
| Neoplasms | Epigenetic Alterations | DNA methylation, a widely used epigenetic mark, has been associated with many tumors. | 21830905 |
| Aggressive behavior, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | However, few studies have addressed the role of cell-free plasma DNA methylation in discriminating aggressive prostate cancer (PCa) from indolent cases. | 21830905 |
| Neoplasms | Epigenetic Alterations | DNA methylation levels were significantly higher in tumor tissue than in adjacent nontumor tissue for p16 (CDKN4A), GSTP1, and APC; GSTP1 had a higher average percentage methylation in tumor tissue (38.9%) compared with p16 (CDKN4A) (5.9%) and APC (14.5%). | 21830905 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). | 21831520 |
| Malignant Neoplasms, Stomach Carcinoma | Epigenetic Alterations | Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. | 21831520 |
| Islet Cell Tumor | Epigenetic Alterations | RASSF1A gene silencing by DNA methylation has been suggested as a major event in pancreatic endocrine tumor (PET) but RASSF1A expression has never been studied. | 21838870 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Our results suggest that aberrant histone modifications may play an important role in the development and progression of ESCC. | 21843048 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Abnormal histone acetylation and methylation levels in esophageal squamous cell carcinomas. | 21843048 |
| Malignant Neoplasms | Epigenetic Alterations | We aimed to identify novel DNA methylation biomarkers common to these three urological cancers, potentially suitable for non-invasive testing. | 21847011 |
| Maxillary Sinus Squamous Cell Carcinoma, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma. | 21847129 |
| Maxillary Sinus Squamous Cell Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | On the basis of the microRNA (miRNA) expression signature of maxillary sinus squamous cell carcinoma (MSSCC), we found that miR-874 was significantly reduced in cancer cells. | 21847129 |
| Neoplasms | Epigenetic Alterations | The downregulation of miR-874 was a frequent event in MSSCC, which suggests that miR-874 functions as a tumour suppressive miRNA, directly regulating PPP1CA that has a potential role of an oncogene. | 21847129 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | Moreover, we have shown CpG island-associated promoter of MLL3 gene has no DNA methylation in CRC cells but also primary tumor and normal colon, and this region has a highly homologous of pseudo gene (psiTPTE22) that was age relate DNA methylation. | 21853109 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | In attempt to discover novel aberrantly hypermethylated genes with putative tumor suppressor function in epithelial ovarian cancer (EOC), we applied expression profiling following pharmacologic inhibition of DNA methylation in EOC cell lines. | 21856257 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The role of p16 is gaining importance in non-small cell lung cancer (NSCLC) because of epigenetic therapy options. | 21857254 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | The DNA methylation inhibitor 5-aza-2-deoxycytidine (DAC) is approved for the treatment of myelodysplastic syndromes (MDS), but resistance to DAC develops during treatment and mechanisms of resistance remain unknown. | 21858090 |
| malignant disease, Choledocholithiasis | Epigenetic Alterations | Using high-throughput real-time PCR-based miRNA microarrays, the expression profiles of 667 miRNAs were compared in patients with malignant disease (n = 9) and age-matched patients with the benign disease choledocholithiasis (n = 9). | 21858175 |
| Primary malignant neoplasm | Epigenetic Alterations | In recent years, it has been suggested that profiles for circulating miRNAs, as well as those for tissue miRNAs, have the potential to be used as diagnostic biomarkers for cancer. | 21858175 |
| Hepatobiliary Disorder | Epigenetic Alterations | These findings suggest that bile miRNAs could be informative biomarkers for hepatobiliary disease and that some miRNAs, particularly miR-9, may be helpful in the diagnosis and clinical management of BTC. | 21858175 |
| Adrenocortical carcinoma | Epigenetic Alterations | The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma. | 21859927 |
| Agenesis of corpus callosum, Adenoma | Epigenetic Alterations | miRNA expression profiles were determined in a series of ACC, adenoma, and normal cortices using microarray. | 21859927 |
| Adenoma | Epigenetic Alterations | A subset of miRNAs showed distinct expression patterns in the ACC compared with adrenal cortices and adenomas. | 21859927 |
| Agenesis of corpus callosum, Tumors of Adrenal Cortex | Epigenetic Alterations | In summary, we identified additional miRNAs associated with ACC, elucidated the functional role of four miRNAs in the pathogenesis of ACC cells, demonstrated the potential involvement of the pro-apoptotic factor PUMA (a miR-483-3p target) in adrenocortical tumors, and found novel miRNAs associated with survival in ACC. | 21859927 |
| Colorectal Carcinoma | Epigenetic Alterations | Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. | 21862635 |
| Secondary malignant neoplasm of female breast | Epigenetic Alterations | In cooperation with Polycomb complex PRC2, the HOTAIR long ncRNA is reported to reprogram chromatin organization and promote breast cancer metastasis. | 21862635 |
| Clinical Coordinator, Breast Carcinoma | Epigenetic Alterations | Our findings suggest that HOTAIR expression is associated with a genome-wide reprogramming of PRC2 function not only in breast cancer but also in CRC, where upregulation of this long ncRNA may be a critical element in metastatic progression. | 21862635 |
| Primary malignant neoplasm | Epigenetic Alterations | The functional impact of recently discovered long noncoding RNAs (ncRNAs) in human cancer remains to be clarified. | 21862635 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNAs (miRNA) are tiny, noncoding, small, endogenous RNAs that play major roles in neoplastic transformation and could therefore offer a better quantitative and noninvasive method for the diagnosis and prognosis of colorectal cancer (CRC) using feces. | 21863218 |
| Clinical Coordinator | Epigenetic Alterations | We demonstrated that miRNAs are stable in the fecal microenvironment, and that, among them, miR-144* represents a novel fecal-based diagnostic marker for CRC screening. | 21863218 |
| Carcinoma of lung | Epigenetic Alterations | Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers. | 21864403 |
| Peripheral Nerve Neoplasms, Malignant | Epigenetic Alterations | We then validate the miRNA panel in a testing set of 76 patients with malignant SPNs and 80 patients with benign SPNs. | 21864403 |
| Carcinoma of lung | Epigenetic Alterations | We previously demonstrated that microRNAs (miRNAs) could be used as biomarkers for lung cancer diagnosis. | 21864403 |
| Lung Neoplasms | Epigenetic Alterations | The three miRNAs used in combination produced the area under receiver operating characteristic curve at 0.86 in distinguishing lung tumors from benign SPNs with 75.00% sensitivity and 84.95% specificity. | 21864403 |
| Carcinoma of lung | Epigenetic Alterations | The plasma miRNAs provide potential circulating biomarkers for noninvasively diagnosing lung cancer among individuals with SPNs, and could be further evaluated in clinical trials. | 21864403 |
| Neoplasms | Epigenetic Alterations | The growth suppression by miRNAs in PDFS cells is consistent with the hypothesis that the DLK1-MEG3 locus plays a tumor suppressor role in human NFAs. | 21871428 |
| SERPINB3 wt Allele, Neoplasms | Epigenetic Alterations | A significant association was revealed between some clinicopathological findings and the DNA methylation status of WNT7A (normal vs tumor, P=0.007; T1-2 vs T3-4, P=0.040; I-III vs IV, P=0.016) and WNT10A (N0-N1 vs N2-N3, P=0.046) in the advanced stages of OSCC. | 21874048 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNA expression profiles may become useful biomarkers for diagnostics, prognosis and prediction of response to treat, and it could be a powerful tool for cancer prevention and therapeutics. | 21874264 |
| Stomach Carcinoma | Epigenetic Alterations | Several miRNA expression profiles of miRNAs in gastric cancer have been reported, but these studies screened only few miRNAs and samples used in experiments include several different subtypes of gastric cancers, which decrease the sensitivity to identify new aberrant miRNAs. | 21874264 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Forty miRNA precursors were up-regulated and thirty-six miRNA were down-regulated in intestinal-type gastric cancers (p<0.01). | 21874264 |
| Stomach Carcinoma | Epigenetic Alterations | Identification of new aberrantly expressed miRNAs in intestinal-type gastric cancer and its clinical significance. | 21874264 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Sixteen new miRNAs were found in intestinal-type gastric cancers. | 21874264 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Seventeen new miRNAs were found in intestinal-type gastric cancers. | 21874264 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Taken together, aberrantly expressed miRNAs may offer new clues to tumorigenesis of gastric cancers. | 21874264 |
| Carcinogenesis | Epigenetic Alterations | Change in MTHFR activity may influence both DNA methylation and synthesis, crucial steps in carcinogenesis. | 21875294 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. | 21878637 |
| Hollings Cancer Center | Epigenetic Alterations | Compelling evidence has suggested the important roles of microRNAs in HCC development. | 21878637 |
| Prostate Cancer Pathway, Metastasis, Prostatic Intraepithelial Neoplasias | Epigenetic Alterations | MicroRNA expression profiles in the progression of prostate cancer--from high-grade prostate intraepithelial neoplasia to metastasis. | 21880514 |
| Metastasis | Epigenetic Alterations | Interestingly, there was a significant global loss of miRNA expression between HGPIN and metastasis at 2 important steps. | 21880514 |
| Carcinogenesis | Epigenetic Alterations | The importance of our study is in the identification of possible miRNAs and miRNA-targeted genes involved in the progression of prostate carcinogenesis that may help the development of potential diagnostic or prognostic markers as well as the design of new target therapies. | 21880514 |
| Acute myocardial infarction | Epigenetic Alterations | Circulating microRNAs are promising novel biomarkers of acute myocardial infarction. | 21881276 |
| Malignant Neoplasms | Epigenetic Alterations | microRNAs (miRNAs), small non-coding RNAs, are always aberrantly expressed in many diseases including human cancers. | 21882196 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Various statistical methods were used to analyze the relationship between miRNA expression and clinicopathologic features and prognosis in 91 patients with ESCC. | 21882196 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Growing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis. | 21883694 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis. | 21890451 |
| Carcinoma of lung | Epigenetic Alterations | Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but microRNA signatures varied between different populations. | 21890451 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Furthermore, we measured the expression of the 13q14-resident microRNAs by quantitative PCR (Q-PCR) in 242 CLL patients and subsequently assessed their prognostic significance. | 21890456 |
| Chronic Kidney Diseases | Epigenetic Alterations | Circulating microRNA expression is reduced in chronic kidney disease. | 21891774 |
| Kidney Failure, Chronic | Epigenetic Alterations | We measured the levels of miRNAs in patients with different stages of chronic kidney failure including those receiving maintenance haemodialysis treatment. | 21891774 |
| Chronic Kidney Diseases, Renal Insufficiency | Epigenetic Alterations | In patients with severe chronic renal failure, circulating levels of total and specific miRNAs are reduced in comparison to patients with mild renal impairment or normal renal function. | 21891774 |
| Chronic Kidney Diseases, Hyperparathyroidism, Anemia | Epigenetic Alterations | A strong correlation exists between detected circulating miRNAs and estimated glomerular filtration rate, and less strong correlations with other features of chronic kidney disease, such as anaemia and hyperparathyroidism. | 21891774 |
| Endometrial Carcinoma | Epigenetic Alterations | The microRNA-200 family is upregulated in endometrial carcinoma. | 21897839 |
| Chronic active hepatitis | Epigenetic Alterations | We compared the expression profiles of 723 human miRNAs from 14 cases of EEC, 10 cases of CAH, and 10 normal proliferative endometria controls using Agilent Human miRNA arrays following RNA extraction from formalin-fixed paraffin-embedded (FFPE) tissues. | 21897839 |
| Chronic active hepatitis | Epigenetic Alterations | This information contributes to the candidate miRNA expression profile that has been generated for EEC and shows that certain miRNAs are dysregulated in the precursor lesion, CAH. | 21897839 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs are dysregulated in cancer and may play essential roles in tumorigenesis. | 21897839 |
| Primary malignant neoplasm | Epigenetic Alterations | Additionally, miRNAs have been shown to have prognostic and diagnostic value in certain types of cancer. | 21897839 |
| Chronic active hepatitis | Epigenetic Alterations | Forty-three miRNAs were dysregulated in EEC and CAH compared to normal controls (p<0.05). | 21897839 |
| Breast Carcinoma, Breast Cancer Cell | Epigenetic Alterations | Large-scale profiling approaches have revealed global down-regulation of microRNAs (miRNAs) in several human cancer types including breast cancer. | 21898071 |
| Breast Carcinoma | Epigenetic Alterations | In conclusion, the decreased expression of Dicer and Drosha may play a role in down-regulation of miRNAs in breast cancer. | 21898071 |
| Primary Biliary Cholangitis | Epigenetic Alterations | We hypothesized that CD40L may play a key role in the pathogenesis of the elevated serum IgM and analyzed genetic and epigenetic modifications of the gene coding for CD40L in CD4(+) and CD8(+) T cells isolated from circulating mononuclear cells from PBC patients and healthy controls. | 21898485 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia. | 21898529 |
| Neoplasms | Epigenetic Alterations | Epigenetic therapy to reactivate tumor suppressor genes may enhance the anti-proliferative effect of erlotinib. | 21901396 |
| Carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | We searched the published literature for the miRNA microarray data of primary lung cancer and selected 15 miRNAs that were most frequently up-regulated in lung cancer tissues. | 21904633 |
| Carcinoma of lung | Epigenetic Alterations | Plasma microRNAs as novel biomarkers for early detection of lung cancer. | 21904633 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNAs (miRNAs), a family of 19- to 25-nucleotide non-coding small RNAs, are frequently dysregulated in lung cancer. | 21904633 |
| Carcinoma of lung | Epigenetic Alterations | The levels of miRNAs were determined by real-time RT-PCR in 74 lung cancer patients and 68 age-matched cancer-free controls. | 21904633 |
| Carcinoma of lung | Epigenetic Alterations | The combination of these 3 miRNAs yielded 81.33% sensitivity and 86.76% specificity in discriminating lung cancer patients from controls. | 21904633 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Taking this into account, we evaluated if genetic and/or epigenetic variation in the ATM gene may modulate the individual susceptibility to develop CLL. | 21910157 |
| Prostate carcinoma | Epigenetic Alterations | Promoter hypermethylation is an important epigenetic mechanism in the regulation of several key modulators of prostate carcinoma progression. | 21912429 |
| Pancreatic carcinoma | Epigenetic Alterations | Combination of plasma microRNAs with serum CA19-9 for early detection of pancreatic cancer. | 21913185 |
| Primary malignant neoplasm | Epigenetic Alterations | Serum microRNAs have the potential to be valuable biomarkers of cancer. | 21914171 |
| Malignant Neoplasms, Carcinogenesis | Epigenetic Alterations | NADPH oxidase DUOX1, DUOX2, and NOX4 have recently been gained considerable concerns, owing to the fact that they involve in reactive oxygen species-induced genetic and epigenetic alternations of human carcinogenesis and serve as biomarkers in several cancers. | 21915726 |
| Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation plays a critical role in carcinogenesis, and the availability of dietary factors involved in 1-carbon metabolism may contribute to aberrant DNA methylation. | 21916701 |
| Malignant Neoplasms, Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Micro RNAs are often aberrantly expressed in cancer and microRNA-21 is upregulated in a variety of cancers, including breast cancer. | 21917003 |
| Neoplasms | Epigenetic Alterations | Our result enlightens the accumulation of aberrant DNA methylation which occurs in concordance with the tumor progression. | 21917081 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer. | 21917081 |
| Ischemia, Primary malignant neoplasm | Epigenetic Alterations | Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue. | 21917534 |
| Primary malignant neoplasm | Epigenetic Alterations | Several of the 56 miRNAs have been reported to play a role in cancer, such as hsa-miR-663 and hsa-miR-125a-3p. | 21917534 |
| Ischemia | Epigenetic Alterations | Caution should be taken when the miRNAs and mRNAs reported to be affected by ischemia time are included in a prognostic or predictive signature. | 21917534 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Aberrant DNA methylation and concomitant transcriptional silencing of death-associated protein kinase 1 (DAPK1) have been demonstrated to be key pathogenic events in chronic lymphocytic leukemia (CLL). | 21918973 |
| SF3B1 wt Allele, Leukemia, Myelocytic, Acute, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | In acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), however, the presence of elevated DNA methylation levels has been a matter of continued controversy. | 21918973 |
| Maxillary Sinus Squamous Cell Carcinoma, Neoplasms | Epigenetic Alterations | Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma. | 21922130 |
| Primary malignant neoplasm, Maxillary Sinus Squamous Cell Carcinoma | Epigenetic Alterations | The expression of microRNA-375 (miR-375) is significantly reduced in cancer tissues of maxillary sinus squamous cell carcinoma (MSSCC). | 21922130 |
| Clinical Coordinator | Epigenetic Alterations | We found 75 candidate genes that were potentially suppressed by DNA methylation in CRC. | 21922135 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA profiling differentiates colorectal cancer according to KRAS status. | 21922590 |
| Neoplasms | Epigenetic Alterations | Recent studies have shown the important role of microRNAs (miRNAs) in a variety of biological processes, and in its ability to distinguish tumors according to their prognostic and predictive properties. | 21922590 |
| Neoplasms | Epigenetic Alterations | Comparing these with normal colon tissue, we identified 49 miRNAs--including 19 novel miRNAs--significantly deregulated in tumor tissue. | 21922590 |
| Neoplasms | Epigenetic Alterations | Polycomb group genes (PcGs) are epigenetic modifiers involved in tumor suppressor gene silencing. | 21926398 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations also affect the expression of cancer genes, either alone or in combination with genetic mechanisms. | 21928112 |
| Malignant Neoplasms | Epigenetic Alterations | The current evidence suggests that hypermethylation of promoter CpG islands is a common epigenetic event in a variety of human cancers. | 21928112 |
| FHIT protein, human | Epigenetic Alterations | Furthermore, inactivation of FHIT by epigenetic mechanisms in GBM may not be associated with brain tumorigenesis. | 21928112 |
| Clinical Coordinator | Epigenetic Alterations | MiRNA levels in CRC tissues and stool samples were detected by real-time quantitative reverse transcription PCR. | 21930727 |
| Clinical Coordinator, polyps | Epigenetic Alterations | Stool miRNA are useful for screening CRC and polyps. | 21930727 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm | Epigenetic Alterations | Carcinogenesis of intraductal papillary mucinous neoplasm of the pancreas: loss of microRNA-101 promotes overexpression of histone methyltransferase EZH2. | 21932133 |
| Hollings Cancer Center | Epigenetic Alterations | Up-regulation of ABC transporters in HCC occurs prior to chemotherapeutic treatment and is associated with miRNA down-regulation. | 21932399 |
| Liver carcinoma | Epigenetic Alterations | Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs. | 21932399 |
| Hollings Cancer Center | Epigenetic Alterations | Because cellular microRNAs (miRNAs) are involved in posttranscriptional gene silencing, we hypothesized that regulation of ABC expression in HCC might be mediated by miRNAs. | 21932399 |
| Hollings Cancer Center | Epigenetic Alterations | Up-regulation of five ABC genes appears to be mediated by 13 cellular miRNAs in HCC patient samples. | 21932399 |
| Colorectal Cancer Pathway, Neoplasm Metastasis | Epigenetic Alterations | MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4. | 21934092 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) regulate tumor progression and invasion via direct interaction with target messenger RNAs (mRNAs). | 21934092 |
| DICER1 protein, human | Epigenetic Alterations | Dicer, a ribonuclease III-like enzyme is essential for miRNA processing. | 21937200 |
| TSPYL2 wt Allele | Epigenetic Alterations | Our data suggest Dicer expression as a possible molecular marker in patients with MF and apparently indicate that miRNA(s) might be of clinical relevance in CTCL. | 21937200 |
| Lymphoma, T-Cell, Cutaneous, Neoplasms | Epigenetic Alterations | Aberrant expression of microRNAs (miRNAs) has been implicated in oncogenesis of various tumors and primary cutaneous T cell lymphomas. | 21937200 |
| Carcinogenesis, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Because of the involvement of miRNA in carcinogenesis, miRNAs in CSF may serve as unique biomarkers for minimally invasive diagnosis of glioma. | 21937590 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma. | 21937590 |
| Glioma | Epigenetic Alterations | Accordingly, miRNAs in the CSF have the potential to serve as novel biomarkers for the detection of gliomas. | 21937590 |
| nucleolin | Epigenetic Alterations | Nucleolin seems to be over-expressed in highly proliferative cells and is involved in many aspect of gene expression: DNA recombination and replication, RNA transcription by RNA polymerase I and II, rRNA processing, mRNA stabilization, cytokinesis, and apoptosis. | 21938743 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Gene expression networks in COPD: microRNA and mRNA regulation. | 21940491 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | miRNA and mRNA expression were compared to enrich for biological networks relevant to the pathogenesis of COPD. | 21940491 |
| Lung Diseases, Obstructive, Chronic Obstructive Airway Disease | Epigenetic Alterations | Lung tissue from smokers with no evidence of obstructive lung disease (n=9) and smokers with COPD (n=26) was examined for miRNA and mRNA expression followed by validation. | 21940491 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | miRNA and mRNA expression profiles enriched for biological pathways that may be relevant to the pathogenesis of COPD including the transforming growth factor b, Wnt and focal adhesion pathways. | 21940491 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | miRNA and mRNA are differentially expressed in individuals with COPD compared with smokers without obstruction. | 21940491 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Identifying expression patterns of miRNAs in COPD may enhance our understanding of the mechanisms of disease. | 21940491 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | 70 miRNAs and 2667 mRNAs were differentially expressed between lung tissue from subjects with COPD and smokers without COPD. | 21940491 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | miR-223 and miR-1274a were the most affected miRNAs in subjects with COPD compared with smokers without obstruction. | 21940491 |
| Disease | Epigenetic Alterations | MicroRNAs are small non-coding RNAs involved in normal processes such as development and differentiation as well as progression of human diseases. | 21943223 |
| Lichen Planus | Epigenetic Alterations | Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus. | 21943223 |
| Prostate Cancer Pathway | Epigenetic Alterations | The investigational ProCaM(tm) prostate cancer methylation assay detects aberrant methylation of DNA in cells associated with prostate cancer. | 21944123 |
| Prostate Cancer Pathway | Epigenetic Alterations | The assay is designed to detect epigenetic modifications in the 3 markers GSTP1, RARb2 and APC, which are indicative of prostate cancer. | 21944123 |
| Stomach Carcinoma | Epigenetic Alterations | This study underscores the potential application of measurement of serum DNA methylation of these genes, as promising tool for gastric cancer detection. | 21945024 |
| Antigen-Presenting Cells, Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | [Expression of DNA methylation of APC in peripheral blood and tumor tissue in patients with esophageal squamous cell carcinoma]. | 21948542 |
| Upper Gingival Squamous Cell Carcinoma | Epigenetic Alterations | Revisit of field cancerization in squamous cell carcinoma of upper aerodigestive tract: better risk assessment with epigenetic markers. | 21952583 |
| Malignant Neoplasms | Epigenetic Alterations | Traditional risk factors allowed us to discriminate between patients with and without cancers with 74% sensitivity (95% CI: 67%-81%), 74% specificity (66%-82%), and 80% area under the curve (67%-91%); epigenetic markers in normal esophageal mucosa had values of 74% (69%-79%), 75% (67%-83%), and 83% (79%-87%); and both together had values of 82% (76%-88%), 81% (74%-88%), and 91% (88%-94%). | 21952583 |
| Hematologic Neoplasms | Epigenetic Alterations | Homeobox (HOX) gene transcription factors are frequently deregulated in hematologic malignancies and involved in leukemogenic transformation [1]. | 21953534 |
| Lynch Syndrome | Epigenetic Alterations | Constitutional epimutations of DNA mismatch repair (MMR) genes have been recently reported as a possible cause of Lynch syndrome. | 21953887 |
| Lynch Syndrome | Epigenetic Alterations | A cohort of 134 unrelated Lynch syndrome-suspected patients without MMR germline mutation was screened for constitutional epimutations of MLH1 and MSH2 by quantitative bisulfite pyrosequencing. | 21953887 |
| Neoplasms | Epigenetic Alterations | Tumors from patients with constitutional epimutations were extensively analyzed. | 21953887 |
| Colonic Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | For one of them, we report for the first time evidence of transmission to two children who also developed early colonic tumors, indicating that constitutional MLH1 epimutations are associated to a real risk of transgenerational inheritance of cancer susceptibility. | 21953887 |
| Primary malignant neoplasm | Epigenetic Alterations | Evidence of constitutional MLH1 epimutation associated to transgenerational inheritance of cancer susceptibility. | 21953887 |
| BRAF gene, Neoplasms | Epigenetic Alterations | Moreover, a somatic BRAF mutation was detected in one affected child, indicating that tumors from patients carrying constitutional MLH1 epimutation can mimic MSI-high sporadic tumors. | 21953887 |
| Plaque, Atherosclerotic | Epigenetic Alterations | Somatic mutation theory of atherogenesis proved by alterations at the DNA level such as "loss of heterozygosity" and microsatellite instability in atherosclerotic plaque is complemented by the date of epigenetic variability of genetic loci involved in the pathological process. | 21954592 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | Standardized incidence rates for thyroid cancer were 72 [95% confidence interval (CI), 51-99; P < 0.001] for pathogenic PTEN mutations, 63 (95% CI, 42-92; P < 0.001) for SDHx variants, and 45 (95% CI, 26-73; P < 0.001) for KLLN epimutations. | 21956414 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks. | 21960591 |
| Primary malignant neoplasm, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Aberrant DNA methylation is a hallmark of cancer, including AML. | 21960591 |
| Clinical Coordinator | Epigenetic Alterations | Here we used TaqMan Array MicroRNA Cards, capable of detecting 664 unique human microRNAs (miRNAs), to describe changes of the miRNA transcriptome following disruption of beta-catenin/TCF4 activity in DLD1 CRC cells. | 21963845 |
| Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Attenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes. | 21963845 |
| Clinical Coordinator | Epigenetic Alterations | Several of these miRNAs (miR-145, miR-126, miR-30e-3p and miR-139-5p) markedly inhibited CRC cell growth in vitro when ectopically expressed. | 21963845 |
| methylene chloride, Heart failure | Epigenetic Alterations | Consistent with murine DCM caused by genetic disruption of histone deacetylases, the data implicate an inherited basis for epigenetic dysregulation in human heart failure. | 21965549 |
| Mycosis Fungoides | Epigenetic Alterations | Altered microRNA expression in mycosis fungoides. | 21966986 |
| Hematologic Neoplasms, Neoplasms | Epigenetic Alterations | Altered expression of different microRNAs has been observed in both solid tumours and haematological malignancies. | 21966986 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis. | 21967505 |
| CpG Island Methylator Phenotype, Carcinogenesis, Malignant neoplasm of endometrium | Epigenetic Alterations | CIMP+ is an important and frequent epigenetic event in endometrial cancer or adjacent NET, and may be a biomarker for predicting early carcinogenesis. | 21968189 |
| Carcinoma | Epigenetic Alterations | microRNAs (miRs) are endogenous small non-coding RNAs that are aberrantly expressed in various carcinomas. | 21971665 |
| Schizophrenia | Epigenetic Alterations | Several genes that were dysregulated in both individuals with schizophrenia and their siblings related to nucleosome and histone structure and function, suggesting a potential epigenetic mechanism underlying the risk state for the disorder. | 21972136 |
| Breast Carcinoma | Epigenetic Alterations | Contribution of epigenetic alteration of BRCA1 and BRCA2 genes in breast carcinomas in Tunisian patients. | 21978880 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Epigenetic regulation of death-associated protein kinase expression in primary gastric cancers from Chinese patients. | 21979297 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Promoter methylation is an important mechanism by which tumor suppressor gene transcription is repressed in cancer cells. | 21979297 |
| Dyskeratosis Congenita | Epigenetic Alterations | The relationship between DNA methylation and telomere length in dyskeratosis congenita. | 21981348 |
| Primary malignant neoplasm | Epigenetic Alterations | Since the discovery of small non-coding RNAs, the analyses of microRNA (miRNA) expression patterns in human cancer have provided new insights into cancer biology. | 21983937 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma. | 21983937 |
| Malignant Neoplasms, Pancreatic carcinoma | Epigenetic Alterations | miRNA-21 has been suggested to be one of the miRNAs that have an important role in the development or biological behavior of a variety of malignancies, including pancreatic cancer. | 21983937 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | The miRNA most highly expressed in pancreatic ductal adenocarcinomas (ie, miRNA-21) was further assessed by quantitative real-time reverse transcription PCR (RT-PCR) assays in the 65 pancreatic ductal adenocarcinoma cases. | 21983937 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | miRNA-21 was the most significantly overexpressed miRNA in the pancreatic ductal adenocarcinomas analyzed, and was also highly expressed in 75% of the 65 pancreatic ductal adenocarcinomas examined by real-time RT-PCR. | 21983937 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | High miRNA-21 expression was correlated with a worse prognosis in the pancreatic ductal adenocarcinoma patients (P=0.045). | 21983937 |
| Pancreatic Ductal Adenocarcinoma, Neoplasms | Epigenetic Alterations | Our data suggest that an overexpression of miRNA-21 is, therefore, associated with the biological behavior of pancreatic ductal adenocarcinoma via the downregulation of the expression of tumor suppressors, PDCD4 and TIMP3, thus resulting in tumor progression and the adverse clinical course of pancreatic ductal adenocarcinoma. | 21983937 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA expression is altered in cancer cells, and microRNAs could serve as diagnostic/prognostic biomarker for cancer patients. | 21984948 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA levels are distinctly increased in cancer patients, although only a small subset of circulating microRNAs has a tumor-specific origin. | 21984948 |
| B-Cell Lymphomas | Epigenetic Alterations | Serum microRNAs are promising novel biomarkers for diffuse large B cell lymphoma. | 21987025 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are regulatory RNA molecules that are deregulated in many disease types, including cancer. | 21987025 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, miRNAs have shown promise as markers for cancer diagnosis. | 21987025 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | In conclusion, these data suggest that serum miRNAs are potentially useful tools as novel noninvasive biomarker for the diagnosis of DLBCL. | 21987025 |
| Malignant neoplasm of urinary bladder, Enrichment (technique) | Epigenetic Alterations | Subsequent enrichment-based bioprocess mapping revealed alterations in phase I/II metabolism and suggested a possible role for DNA methylation in perturbing xenobiotic metabolism in bladder cancer. | 21990318 |
| Stomach Carcinoma | Epigenetic Alterations | When recombinant EBV was introduced into the EBV(-)/low-methylation epigenotype gastric cancer cell, MKN7, 3 independently established subclones displayed increases in DNA methylation. | 21990320 |
| Communicable Diseases, Stomach Carcinoma, Malignant neoplasm of stomach | Epigenetic Alterations | In summary, DNA methylation profiling classified gastric cancer into 3 epigenotypes, and EBV(+) gastric cancers showed distinct methylation patterns likely attributable to EBV infection. | 21990320 |
| Colorectal Cancer Pathway | Epigenetic Alterations | A let-7 microRNA SNP in the KRAS 3UTR is prognostic in early-stage colorectal cancer. | 21994416 |
| Clinical Coordinator | Epigenetic Alterations | Recently, a SNP in a lethal-7 (let-7) miRNA complementary site (LCS6) in the KRAS 3untranslated region was suggested to affect survival in metastatic CRC. | 21994416 |
| Diabetes Mellitus | Epigenetic Alterations | Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. | 21994764 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Inter-individual DNA methylation variations were frequently hypothesized to alter individual susceptibility to Type 2 Diabetes Mellitus (T2DM). | 21994764 |
| Tuberculosis, Pulmonary | Epigenetic Alterations | Circulating microRNAs in patients with active pulmonary tuberculosis. | 21998423 |
| Tuberculosis, Pulmonary | Epigenetic Alterations | In all, for the first time our results revealed that a number of miRNAs were differentially expressed during active pulmonary tuberculosis infection, and circulating miR-29a has great potential to serve as a marker for the detection of active pulmonary tuberculosis infection. | 21998423 |
| Primary malignant neoplasm | Epigenetic Alterations | Based on The Cancer Genome Atlas (TCGA), discovery and validation sets with gene, microRNA, and quantitative MR-imaging data were created. | 21998659 |
| Parkinson Disease | Epigenetic Alterations | Convergence of miRNA expression profiling, a-synuclein interacton and GWAS in Parkinsons disease. | 22003392 |
| nervous system disorder, Parkinson Disease, palladium | Epigenetic Alterations | miRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinsons disease (PD). | 22003392 |
| Unknown (origin) (qualifier value) | Epigenetic Alterations | These findings suggest that several miRNAs may act as regulators of both known and novel biological processes leading to idiopathic PD. | 22003392 |
| Disease, Degenerative polyarthritis | Epigenetic Alterations | MicroRNAs (miRNAs) are a family of non-coding RNAs that play an important role in human diseases, including osteoarthritis (OA). | 22006119 |
| Degenerative polyarthritis | Epigenetic Alterations | Changes in microRNA expression in peripheral mononuclear cells according to the progression of osteoarthritis. | 22006119 |
| Clinical Coordinator | Epigenetic Alterations | The DNA methylation of each marker was quantified using combined bisulfite restriction analysis (COBRA) and analyzed along with various genetic factors associated with CRC [the BRAF and KRAS mutations, MLH1 methylation and microsatellite instability (MSI)]. | 22006538 |
| Aortic Aneurysm, Thoracic | Epigenetic Alterations | Selective microRNA suppression in human thoracic aneurysms: relationship of miR-29a to aortic size and proteolytic induction. | 22010139 |
| Carcinoma of lung | Epigenetic Alterations | Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. | 22011669 |
| Malignant Neoplasms | Epigenetic Alterations | The recent DNA methylation studies on cancers have revealed the necessity of profiling an entire human genome and not to restrict the profiling to specific regions of the human genome. | 22011669 |
| Carcinogenesis | Epigenetic Alterations | It has been suggested that genome-wide DNA methylation analysis enables us to identify the genes that are regulated by DNA methylation in carcinogenesis. | 22011669 |
| Inflammation, Primary malignant neoplasm | Epigenetic Alterations | A protein connected to inflammation and suggested to be involved in cancer development is cyclooxygenase-2 (COX-2) which can be inhibited by microRNA-26b (miR-26b). | 22017396 |
| Malignant neoplasm of stomach stage IV | Epigenetic Alterations | However, the mechanisms by which miRNAs regulate gastric cancer metastasis remain poorly understood. | 22018270 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis. | 22018284 |
| Malignant neoplasm of pancreas | Epigenetic Alterations | We also analyzed the expression levels of this miRNA in microdissected (n = 15) and formalin-fixed, paraffin-embedded (FFPE) (n = 115) samples from pancreatic cancers by quantitative RT-PCR. | 22018284 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) have been gaining attention as new, key molecules that contribute to carcinogenesis. | 22018284 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis. | 22018950 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) have been implicated in a variety of human diseases including cancer, and have many characteristics of an ideal biomarker most notably their inherent stability and resilience. | 22018950 |
| Clinical Coordinator | Epigenetic Alterations | (III) We examined the correlation between the expressions of candidate serum miRNAs with clinical parameters of CRC patients. | 22018950 |
| Colorectal Cancer Pathway | Epigenetic Alterations | NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA. | 22018986 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Caffeine and caffeic acid, major coffee constituents, have been shown to suppress mammary tumor formation in animal models and to inhibit DNA methylation in human breast cancer cells, respectively. | 22020403 |
| Colorectal Cancer Pathway, Colorectal Adenomatous Polyp | Epigenetic Alterations | DNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polyps. | 22020530 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have emerged as important gene regulators and are recognized as oncogenes or tumor suppressor genes in carcinogenesis. | 22020746 |
| Neoplasms | Epigenetic Alterations | ccRCC cases with particular VHL germline polymorphisms were more likely to have VHL inactivation through promoter hypermethylation than through sequence alterations in tumor DNA, suggesting that the presence of these SNPs may represent an example of facilitated epigenetic variation (an inherited propensity towards epigenetic variation) in renal tissue. | 22022277 |
| Colonic Polyps | Epigenetic Alterations | There are sparse data on genetic, epigenetic and vitamin D exposure in African Americans (AA) with colon polyp. | 22022386 |
| Epidermal cells | Epigenetic Alterations | Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer. | 22025453 |
| Hematologic Neoplasms | Epigenetic Alterations | Next-generation sequencing identifies novel microRNAs in peripheral blood of lung cancer patients. | 22027949 |
| Carcinoma of lung | Epigenetic Alterations | Here, we applied high-throughput SOLiD transcriptome sequencing of miRNAs expressed in human peripheral blood of patients with lung cancer. | 22027949 |
| Primary malignant neoplasm | Epigenetic Alterations | In addition, we identified 32 annotated and seven unknown miRNAs that were significantly altered in cancer patients. | 22027949 |
| Carcinoma of lung | Epigenetic Alterations | These results demonstrate that deep sequencing of small RNAs bears high potential to quantify miRNAs in peripheral blood and to identify previously unknown miRNAs serving as biomarker for lung cancer. | 22027949 |
| Carcinogenesis | Epigenetic Alterations | Our findings highlight the possible effect of environmental exposures in carcinogenesis through DNA methylation and should have applications in prevention, molecular diagnosis, prognosis, and treatment. | 22028395 |
| Colorectal Carcinoma | Epigenetic Alterations | Distinct genetic and epigenetic signatures of colorectal cancers according to ethnic origin. | 22028395 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer. | 22028396 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Cumulative data have shown that microRNAs (miRNA) are involved in the etiology and prognosis of colorectal cancer (CRC). | 22028396 |
| Clinical Coordinator, Adenocarcinoma | Epigenetic Alterations | We analyzed the effects of seven single-nucleotide polymorphisms (SNP) in pre-miRNA genes on the prognosis of a Chinese population with 408 CRC patients with surgically-resected adenocarcinoma. | 22028396 |
| Clinical Coordinator | Epigenetic Alterations | Our data suggest that genetic polymorphisms in pre-miRNA genes may impact CRC prognosis especially in patients receiving chemotherapy, a finding that warrants further independent validation. | 22028396 |
| Malignant Neoplasms | Epigenetic Alterations | Polycomb group (PcG) proteins are critical epigenetic mediators of stem cell pluripotency, which have been implicated in the pathogenesis of human cancers. | 22028491 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic regulation is an important mechanism leading to cancer initiation and promotion. | 22029821 |
| Vulval intraepithelial neoplasia, Squamous cell carcinoma of vulva, LINC01191 gene | Epigenetic Alterations | Little is known about the epigenetic regulation of vulvar intraepithelial neoplasia (VIN) and vulvar squamous cell cancer (VSCC). | 22029821 |
| Vulvar Neoplasms, LINC01191 gene | Epigenetic Alterations | These results suggest that epigenetic regulation plays a considerable role in the transformation of VIN to invasive vulvar neoplasia. | 22029821 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetic deregulation of Wnt modulators leading to aberrant signaling has been reported in adult patients with acute myeloid leukemia (AML), but its occurrence in childhood patients with AML and the role of individual modulators are unclear. | 22031861 |
| Cytogenetically normal acute myeloid leukemia, Leukemia, Myelocytic, Acute | Epigenetic Alterations | The associations of mutations in the enhancer of trithorax and polycomb family gene ASXL1 with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression profiles in primary cytogenetically normal acute myeloid leukemia (CN-AML) are unknown. | 22031865 |
| Frontotemporal Lobar Degeneration | Epigenetic Alterations | Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations. | 22032330 |
| GRN gene, Frontotemporal dementia | Epigenetic Alterations | Using miRNA array profiling, we identified the 20 miRNAs that showed greatest evidence (unadjusted P < 0.05) of dysregulation in frontal cortex of eight FTLD-TDP patients carrying PGRN mutations when compared to 32 FTLD-TDP patients with no apparent genetic abnormalities. | 22032330 |
| Progranulins, Frontotemporal Lobar Degeneration, GRN gene, Frontotemporal dementia | Epigenetic Alterations | Here we examine the role of miRNAs in FTLD patients with TAR DNA-binding protein 43 pathology (FTLD-TDP) caused by genetic mutations in the progranulin (PGRN) gene. | 22032330 |
| GRN gene | Epigenetic Alterations | Additional qRT-PCR analyses showed that 5 out of 9 miRNAs (miR-922, miR-516a-3p, miR-571, miR-548b-5p, and miR-548c-5p) were also significantly dysregulated (unadjusted P < 0.05) in cerebellar tissue samples of PGRN mutation carriers, consistent with a systemic reduction in PGRN levels. | 22032330 |
| GRN gene, Frontotemporal dementia | Epigenetic Alterations | Our study suggests that miRNAs may contribute to the pathogenesis of FTLD-TDP caused by PGRN mutations and provides new insight into potential future therapeutic options. | 22032330 |
| Sjogrens Syndrome | Epigenetic Alterations | Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjogrens syndrome. | 22033216 |
| SF3B1 wt Allele | Epigenetic Alterations | Epigenetic regulation of nuclear PI-PLCbeta1 signaling pathway in low-risk MDS patients during azacitidine treatment. | 22033492 |
| Plexiform Neurofibroma, Neurofibromatosis 1 | Epigenetic Alterations | Role of noncoding RNA ANRIL in genesis of plexiform neurofibromas in neurofibromatosis type 1. | 22034633 |
| Kidney Failure, Acute | Epigenetic Alterations | To confirm the functional role of rs2151280, we used real-time quantitative reverse transcription-polymerase chain reaction to analyze the expression of cyclin-dependent kinase inhibitor 2A (CDKN2A), CDKN2B, alternate reading frame (ARF), and antisense noncoding RNA in the INK4 locus (ANRIL) in the peripheral blood of 124 NF1 patients. | 22034633 |
| neurofibroma, Neoplasms | Epigenetic Alterations | Identification of ANRIL as a modifier gene in NF1 may offer clues to the molecular pathogenesis of PNFs, particularly neurofibroma formation, and emphasizes the unanticipated role of large noncoding RNA in activation of critical regulators of tumor development. | 22034633 |
| Breast Carcinoma | Epigenetic Alterations | Although DNA methylation profiles in breast cancer have been connected to breast cancer molecular subtype, there have been no studies of the association of DNA methylation with stem cell phenotype. | 22037257 |
| Breast Carcinoma | Epigenetic Alterations | Taken together, these data indicate loss of klotho expression as an early event in breast cancer development, and suggest a role for DNA methylation and histone deacetylation in klotho silencing. | 22042362 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic silencing of the tumor suppressor klotho in human breast cancer. | 22042362 |
| Intraductal papillary mucinous neoplasm | Epigenetic Alterations | [MicroRNA expression pattern in intraductal papillary mucinous neoplasm]. | 22042419 |
| Malignant Neoplasms | Epigenetic Alterations | The aberrant microRNA expression is commonly observed in many cancers. | 22042419 |
| Pancreatic carcinoma | Epigenetic Alterations | After applying anti-miRNA inhibitors, cell survival of four pancreatic cancer cell lines decreased by 24.5% with anti-miR-196a and by 14.2% with anti-miR-183 on average. | 22042419 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatic carcinoma | Epigenetic Alterations | Two microRNAs, miR-196a and miR-183-increased in IPMN and pancreatic cancer cell lines compared with immortalized dancreatic ductal cell line. | 22042419 |
| Pancreatic carcinoma | Epigenetic Alterations | The inhibitions of these microRNAs repressed cell proliferation of pancreatic cancer cell lines. | 22042419 |
| Lafora Disease | Epigenetic Alterations | To what extent epigenetic changes play a role in the regulation of a-synuclein expression and may contribute to the aetiology of sporadic LBD is a matter of debate. | 22042430 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | MicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation. | 22042971 |
| Obesity, Inflammation | Epigenetic Alterations | The expression of specific microRNA species in obesity, which could also target and post-transcriptionally modulate cytokine mRNA, provides new insight into possible mechanisms of how risk factors might modify periodontal inflammation and may represent novel therapeutic targets. | 22043006 |
| Drug-Induced Liver Disease | Epigenetic Alterations | Circulating microRNAs as potential markers of human drug-induced liver injury. | 22045675 |
| Drug-Induced Liver Disease | Epigenetic Alterations | This work provides the first evidence for the potential use of miRNAs as biomarkers of human drug-induced liver injury. | 22045675 |
| Neoplasms | Epigenetic Alterations | Epigenetic modifications such as methylation of CpG islands in tumor-suppressor gene promoter regions have been associated with tumor development in many human cancers. | 22045684 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNAs as a potential prognostic factor in gastric cancer. | 22046085 |
| Small cell carcinoma of lung | Epigenetic Alterations | Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer. | 22047961 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) can act as oncogenes or tumor-suppressor genes in human malignancy. | 22047961 |
| Malignant Neoplasms, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The miR-34 family is comprised of tumor-suppressive miRNAs, and its reduced expression by methylation has been reported in various cancers, including non-small cell lung cancer (NSCLC). | 22047961 |
| Ventricular Septal Rupture, Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | MicroRNAs, innate immunity and ventricular rupture in human myocardial infarction. | 22048267 |
| Follicular thyroid carcinoma, Follicular adenoma | Epigenetic Alterations | Since microRNA (miRNA) analyses could provide new leads to malignant progression, we characterised the global miRNA expression in follicular adenoma (FA) and follicular carcinoma (FC). | 22049245 |
| In situ follicular neoplasia | Epigenetic Alterations | We conclude that follicular neoplasia is associated with major changes in miRNA expression that may promote malignant transformation by increasing the expression of transcripts encoding tumourigenic factors. | 22049245 |
| Carcinoma, Adenoma | Epigenetic Alterations | Moreover, miRNA profiling may facilitate the diagnosis of carcinoma vs adenoma. | 22049245 |
| Follicular thyroid carcinoma | Epigenetic Alterations | Down-regulation of microRNAs controlling tumourigenic factors in follicular thyroid carcinoma. | 22049245 |
| Carcinoma, Adenoma | Epigenetic Alterations | Comparison of carcinoma and adenoma with normal thyroid revealed 150 and 107 differentially expressed miRNAs respectively. | 22049245 |
| Thyroid Neoplasm | Epigenetic Alterations | Integration of the changed miRNAs with differentially expressed mRNAs demonstrated an enrichment of seed sites among up-regulated transcripts encoding proteins implicated in thyroid tumourigenesis. | 22049245 |
| Squamous cell carcinoma of the head and neck, Malignant Head and Neck Neoplasm | Epigenetic Alterations | Genetic polymorphisms in folate metabolism may affect the risk of head and neck cancer (HNSCC) due to its involvement in DNA methylation and synthesis. | 22051736 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNA) have potential as prognostic biomarkers and therapeutic targets in cancer. | 22052060 |
| Malignant neoplasm of large intestine, Neoplasms, Adenoma | Epigenetic Alterations | miRNA expression profiling in tumour, adenoma and normal colorectal tissues was performed to identify tumour-related miRNAs in the course of colorectal malignant changes. | 22052060 |
| Neoplasms | Epigenetic Alterations | Moreover, patients whose tumours had low miR-150 expression had shorter survival and a worse response to adjuvant chemotherapy than patients whose tumours had high miRNA expression. | 22052060 |
| Primary malignant neoplasm | Epigenetic Alterations | Global hypomethylation is one of the most consistent epigenetic changes in cancer. | 22055592 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Development of hepatocellular carcinoma (HCC) must be understood as a multistep process with accumulation of genetic and epigenetic alterations. | 22055592 |
| Breast Carcinoma, Best Case Imputation Technique | Epigenetic Alterations | We analyzed the expression of several microRNAs (miRs) implicated in breast cancer (BC) pathogenesis (miR-21, miR-10b, miR17-5p, mir-31, miR-155, miR-200c, miR-18a, miR-205, and miR-27a) in 80 breast carcinomas obtained from patients with bilateral BC (biBC) and 40 cases of unilateral BC (uBC). | 22057972 |
| Primary malignant neoplasm | Epigenetic Alterations | Despite the well-established role of the miR-17-92 in cancer formation and progression, the contribution of each individual miRNA remains to be characterized. | 22065543 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs have been shown to offer great potential in both the diagnosis and prognosis of cancer. | 22065543 |
| Primary malignant neoplasm | Epigenetic Alterations | Our recent analyses of miRNA expression signatures showed that miR-1 and miR-133a were significantly reduced in several types of cancer. | 22068816 |
| Carcinogenesis | Epigenetic Alterations | Therefore, identification of novel molecular networks regulated by miRNAs may provide new insights into the underlying causes of PCa oncogenesis. | 22068816 |
| Breast Carcinoma | Epigenetic Alterations | Aberrant expression of miRNAs was involved in various biological and pathological processes, including tumorigenesis of breast cancer. | 22074121 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Leukocyte global DNA methylation levels are currently being considered as biomarkers of cancer susceptibility and have been associated with risk of several cancers. | 22076155 |
| Autoimmune Diseases | Epigenetic Alterations | Increasing evidence indicates that microRNAs (miRNAs) play a vital role in the pathogenesis of inflammatory and autoimmune diseases. | 22077423 |
| Breast Carcinoma | Epigenetic Alterations | LIN28: a regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer. | 22081076 |
| Malignant Neoplasms | Epigenetic Alterations | A tumor-suppressor gene, let-7 microRNA (miRNA) family, is often inactivated in various human malignancies. | 22081076 |
| Breast Carcinoma | Epigenetic Alterations | These results also suggest that LIN28 promotes tumorigenic activity by suppressing let-7 miRNA maturation in breast carcinoma cells. | 22081076 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | MicroRNA (miR) miR-34a, -34b/c, -124-1 and -203 are tumor suppressor miRs implicated in carcinogenesis. | 22082000 |
| Hemangioblastoma, Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. | 22082152 |
| methionine, Hemangioblastoma | Epigenetic Alterations | We hypothesized that hemangioblastomas and Met CCRCC display distinct miRNA signatures enabling their histologic differentiation. | 22082152 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are noncoding cellular small RNA molecules that play an important role in cancer. | 22082152 |
| methionine, Hemangioblastoma | Epigenetic Alterations | MiRNAs were profiled in 10 cases each of hemangioblastomas, Met CCRCC and primary CCRCC. | 22082152 |
| Hemangioblastoma | Epigenetic Alterations | Ten miRNAs had greater abundance (including miR-9 (~10-fold) and miR-135a (~7-fold)) and 39 miRNAs were lower [including miR-200a (~22-fold) and miR-200b (~12-fold)] in hemangioblastomas compared with Met CCRCC. | 22082152 |
| Neoplasms | Epigenetic Alterations | Metastasis-Associated-in-Lung-Adenocarcinoma-Transcript-1 (MALAT-1) is an ncRNA that is highly expressed in several tumor types. | 22088988 |
| Squamous cell carcinoma of lung, Neoplasms | Epigenetic Alterations | Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma. | 22089643 |
| Squamous cell carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | Analysis of the microRNA (miRNA) expression signature of lung squamous cell carcinoma (lung-SCC) revealed that the expression levels of miR-133a were significantly reduced in cancer tissues compared with normal tissues. | 22089643 |
| Carcinogenesis, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The identification of a tumor suppressive miRNA and the novel cancer pathways it regulates could provide new insights into potential molecular mechanisms of lung-SCC carcinogenesis. | 22089643 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs), highly conserved small RNA molecules, may target oncogenes and have potential as a therapeutic strategy against cancer. | 22098779 |
| Neoplasms | Epigenetic Alterations | Enhanced expression of these microRNAs mimics p38a deficiency and increases tumor growth in mouse models, but it also improves the response to chemotherapeutic agents. | 22101765 |
| Meningioma | Epigenetic Alterations | Epigenetic subclassification of meningiomas based on genome-wide DNA methylation analyses. | 22102699 |
| Cardiovascular Diseases | Epigenetic Alterations | Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease. | 22103680 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small, non-coding RNAs that can act as oncogenes or tumor suppressor genes in human cancer. | 22105365 |
| Stage I Esophageal Squamous Cell Carcinoma AJCC v7 | Epigenetic Alterations | Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma. | 22108521 |
| Carcinoma of lung | Epigenetic Alterations | In the identification of subjects with lung cancer, increased DNA methylation of the SHOX2 gene locus in bronchial aspirates has previously been proven to be a clinically valuable biomarker. | 22108652 |
| Clinical Events Domain | Epigenetic Alterations | To facilitate the use in a diagnostic setting, a CE marked in vitro diagnostic test kit to quantify SHOX2 DNA methylation in bronchial aspirates was developed and characterized. | 22108652 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. | 22110741 |
| Carcinoma of lung | Epigenetic Alterations | Epigenetic regulation of miR-212 expression in lung cancer. | 22110741 |
| Primary malignant neoplasm | Epigenetic Alterations | Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. | 22110741 |
| Breast Carcinoma | Epigenetic Alterations | miRNAs (miRs), which are noncoding RNA genes, may respond to estrogen and serve as posttranscriptional regulators in tumorigenic progression, especially in breast cancer; however, only limited information about this possibility is available. | 22113133 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | miRNA-34b as a tumor suppressor in estrogen-dependent growth of breast cancer cells. | 22113133 |
| Breast Carcinoma | Epigenetic Alterations | These findings reveal that miR-34b is an oncosuppressor miRNA requiring both ER+ and wild-type p53 phenotypes in breast cancer cells. | 22113133 |
| Breast Carcinoma | Epigenetic Alterations | These results improve our ability to develop new therapeutic strategies to target the complex estrogenic pathway in human breast cancer progression through miRNA regulation. | 22113133 |
| Nevus cell, melanoma | Epigenetic Alterations | We analyzed the epigenetic inactivation of RASSF2 and RASSF10 in malignant melanoma (MM) of the skin, including 5 MM cell lines, 28 primary MM, 33 metastases of MM, 47 nevus cell nevi (NCN), and 22 control tissues. | 22113481 |
| Vulvar Lichen Sclerosus, Lichen Planus | Epigenetic Alterations | An autoimmune phenotype in vulvar lichen sclerosus and lichen planus: a Th1 response and high levels of microRNA-155. | 22113482 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma. | 22114136 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNA) have potential as diagnostic and prognostic biomarkers and as therapeutic targets in cancer. | 22114136 |
| ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | We sought to establish the relationship between miRNA expression and clinicopathologic parameters, including prognosis, in pancreatic ductal adenocarcinoma (PDAC). | 22114136 |
| Neoplasms | Epigenetic Alterations | miRNA profiling identified expression signatures associated with PDAC, lymph node involvement, high tumor grade, and 20 miRNAs were associated with overall survival. | 22114136 |
| Prostate Cancer Pathway | Epigenetic Alterations | The expression and clinical significance of GTP-binding RAS-like 3 (ARHI) and microRNA 221 and 222 in prostate cancer. | 22117988 |
| Prostate Cancer Pathway | Epigenetic Alterations | Whether ARHI and microRNA 221 and 222 could be considered as biomarkers for disease progression in prostate cancer requires further investigation. | 22117988 |
| Primary malignant neoplasm | Epigenetic Alterations | Focal CpG island hypermethylation and diffuse genomic hypomethylation signify the changes in the DNA methylation status in cancer cells. | 22120154 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Stage-dependent differential expression of microRNAs in colorectal cancer: potential role as markers of metastatic disease. | 22120473 |
| Primary malignant neoplasm | Epigenetic Alterations | Proteins interpreting and modifying histone methylation, such as JmjC-domain and particularly PHD-finger proteins like PHF8, are activated in subsets of PrCas and promote cancer relevant phenotypes. | 22120715 |
| Prostate Cancer Pathway | Epigenetic Alterations | Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion. | 22120715 |
| Primary malignant neoplasm | Epigenetic Alterations | Our study highlights subsets of epigenetic enzymes influencing different cancer cell phenotypes. | 22120715 |
| Heart failure | Epigenetic Alterations | The small non-coding RNAs known as microRNAs regulate gene expression and seem to play an important role in the pathogenesis of heart failure. | 22120965 |
| Heart failure | Epigenetic Alterations | The differences in microRNA levels between the two groups were characterized, and a score, based on the levels of four specific microRNAs with the most significant increase in the heart failure group (miR-423-5p, miR-320a, miR-22, and miR-92b), was defined. | 22120965 |
| Heart failure | Epigenetic Alterations | Serum levels of microRNAs in patients with heart failure. | 22120965 |
| Heart Failure, Systolic | Epigenetic Alterations | Elevated serum levels of specific microRNAs: miR-423-5p, miR-320a, miR-22, and miR-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters. | 22120965 |
| Primary malignant neoplasm, Beckwith-Wiedemann Syndrome | Epigenetic Alterations | Dr Feinberg continued to perform seminal work in cancer epigenetics as a Howard Hughes investigator at the University of Michigan (MI, USA), discovering human imprinted genes and loss of imprinting in cancer, and the molecular basis of Beckwith-Wiedemann syndrome. | 22122634 |
| Prostate Cancer Pathway | Epigenetic Alterations | To evaluate the prognostic significance of six epigenetic biomarkers (AIM1, CDH1, KIF1A, MT1G, PAK3, and RBM6 promoter hypermethlation) in a homogeneous group of prostate cancer patients, following radical prostatectomy (RP). | 22127895 |
| Squamous cell carcinoma | Epigenetic Alterations | MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma. | 22132151 |
| SERPINB3 wt Allele | Epigenetic Alterations | MiRNA expression and DNA methylation changes are a common event in OSCC, and we suggest miR-375, miR-127, miR-137, the miR-200 family and miR-205 as promising candidates for future investigations. | 22132151 |
| SERPINB3 wt Allele, Neoplasms | Epigenetic Alterations | MiRNA expression patterns were consistent in healthy oral epithelium and stroma, but broadly altered in both tumor and adjacent tissue from OSCC patients. | 22132151 |
| SERPINB3 wt Allele | Epigenetic Alterations | Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers, suggesting a potential clinical application for OSCC specific miRNA signatures in oral fluids. | 22132151 |
| SERPINB3 wt Allele, Neoplasms | Epigenetic Alterations | Although overall activated in OSCC, miR-200/miR-205 suppression in oral CSCs indicate that cell specific silencing of these miRNAs may drive tumor expansion and progression. | 22132151 |
| Secondary malignant neoplasm of liver, Colorectal Carcinoma | Epigenetic Alterations | DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis. | 22132162 |
| Colorectal Carcinoma | Epigenetic Alterations | The contribution of DNA methylation to the metastatic process in colorectal cancers (CRCs) is unclear. | 22132162 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | Most DNA methylation differences between primary CRCs and matched liver metastasis are due to random variation and an increase in DNA methylation density rather than de-novo inactivation and silencing. | 22132162 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | Thus, DNA methylation changes occur for the most part before progression to liver metastasis. | 22132162 |
| Carcinogenesis | Epigenetic Alterations | Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the intracellular folate metabolism which plays an important role in carcinogenesis through DNA methylation and nucleotide synthesis. | 22132838 |
| Psoriasis, Disease | Epigenetic Alterations | Although miRNAs are thought to be involved in the pathogenesis of human diseases, little is known about miRNAs in psoriasis. | 22133505 |
| Neoplasms | Epigenetic Alterations | Data further showed increased tumour histone acetylation and decreased phosphorylated ERK protein expression. | 22134508 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway, MIR320A gene, Neoplasms | Epigenetic Alterations | microRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer. | 22134529 |
| Metastasis | Epigenetic Alterations | The expression profile of miRNAs in liver metastasis and primary CRC tissues was analyzed by miRNA microarrays and verified by real-time polymerase chain reaction (PCR). | 22134529 |
| Clinical Coordinator, Colorectal Cancer Pathway, Secondary malignant neoplasm of liver, Neoplasms | Epigenetic Alterations | Although there is emerging evidence that various miRNAs function as oncogenes or tumor suppressors in colorectal cancer (CRC), the role of miRNAs in mediating liver metastasis remains unexplored. | 22134529 |
| Primary malignant neoplasm | Epigenetic Alterations | Germline variants in the 3 untranslated region (3UTR) of cancer genes disrupting microRNA (miRNA) regulation have recently been associated with cancer risk. | 22139083 |
| Lichen Planus | Epigenetic Alterations | Increased miRNA-146a and miRNA-155 expressions in oral lichen planus. | 22139425 |
| Barrett Esophagus | Epigenetic Alterations | DNA methylation profiling in Barretts esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses. | 22139570 |
| Degenerative polyarthritis | Epigenetic Alterations | These included 39 miRNAs that are coexpressed with miRNA-140 (miR-140), which is known to be involved in cartilage homeostasis and osteoarthritis (OA). | 22143896 |
| Degenerative polyarthritis | Epigenetic Alterations | The expression and function of microRNAs in chondrogenesis and osteoarthritis. | 22143896 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNA-223 (miR-223) expression has been demonstrated to be stage-specific in B cell differentiation and associated with the outcome of chronic lymphocytic leukemia (CLL). | 22145958 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma. | 22146010 |
| Liquid Chromatography | Epigenetic Alterations | DNA methylation of RASSF1A, p16(INK4a), RARb, MGMT and DAPK was detected in 12 (30.8%), 3 (7.7%), 11 (28.2%), 0 (0.0%) and five patients (12.8%) with MPM, and in 22 (47.8%), 14 (30.4%), 24 (52.2%), 1 (2.2%) and six patients (13.0%) with LC, respectively. | 22146010 |
| Heart valve disease, Atrial Fibrillation | Epigenetic Alterations | Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease. | 22147268 |
| Right arm | Epigenetic Alterations | There was no detectable effect of chronic AF on miRNA expression in LA tissue, but miRNA expression in RA was strongly influenced by AF, with 47 miRNAs (15 higher, 32 lower) showing differential expression between the AF and control sinus rhythm groups. | 22147268 |
| Right arm | Epigenetic Alterations | VHD induced different changes in miRNA expression in LA compared with RA. | 22147268 |
| Right arm | Epigenetic Alterations | We conclude that VHD and AF influence miRNA expression patterns in LA and RA, but these are affected differently by disease progression and by the development of AF. | 22147268 |
| Right arm | Epigenetic Alterations | Fifty-three (12 higher, 41 lower) miRNAs were altered by VHD in LA, compared with 5 (4 higher, 1 lower) in RA tissue. | 22147268 |
| ST segment elevation myocardial infarction | Epigenetic Alterations | [Circulating microRNA-92a in patients with ST-segment elevation myocardial infarction]. | 22153007 |
| Neoplasms | Epigenetic Alterations | Taken together, our findings indicate that epigenetic silencing of PRDX1 is frequent in 1p/19q-deleted oligodendroglial tumours and likely contributes to radio- and chemosensitivity of these tumours. | 22158042 |
| Ulcerative Colitis | Epigenetic Alterations | Array-based identification of common DNA methylation alterations in ulcerative colitis. | 22159500 |
| Ulcerative Colitis | Epigenetic Alterations | To the best of our knowledge, this work defines the first high-throughput aberrant DNA methylation profiles of the colonic mucosa of UC patients. | 22159500 |
| Primary malignant neoplasm | Epigenetic Alterations | Albeit the causes remain to be understood, epigenetic alterations have been suggested to play a role in the long-term cancer risk of these patients. | 22159500 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We identified epigenetic alterations affecting genes putatively involved in UC disease, and in susceptibility to develop colorectal cancer. | 22159500 |
| Ulcerative Colitis | Epigenetic Alterations | These epigenetic profiles provide novel and relevant knowledge on the molecular alterations associated to the UC pathology. | 22159500 |
| Breast Carcinoma | Epigenetic Alterations | Association of aberrant DNA methylation with clinicopathological features in breast cancer. | 22159596 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation is responsible for the epigenetic silencing of genes associated with tumourigenesis and progression of cancer. | 22159596 |
| Hollings Cancer Center | Epigenetic Alterations | Epigenetic alteration and dysregulation of several pathways including wingless-type MMTV integration site (Wnt), mitogen-activated protein kinase (MAPK) and Janus kinase and signal transducer and activator of transcription (JAK-STAT) are associated with HCC development in Gnmt knockout mice. | 22160218 |
| Infection caused by Helicobacter pylori | Epigenetic Alterations | Interweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection. | 22161133 |
| Neutrophil Infiltration, Polymorphonuclear Cell Infiltrate | Epigenetic Alterations | Among the 17 miRNAs, 15 were associated with the degree of neutrophil infiltration and, more prominently, the degree of mononuclear cell infiltration, according to the updated Sydney system. | 22161133 |
| Inflammation | Epigenetic Alterations | Persistent H. pylori infection may affect the mucosal expression profiles of miRNAs via chronic inflammation mediated by proinflammatory cytokines. | 22161133 |
| Carcinogenesis, Helicobacter-associated gastritis | Epigenetic Alterations | Underscoring the causal association between miRNAs and proinflammatory cytokines may provide insights into the pathogenesis of H. pylori-associated gastritis linking to gastric carcinogenesis. | 22161133 |
| Carcinogenesis, Stomach Neoplasms | Epigenetic Alterations | We previously reported that aberrant DNA methylation is an early and frequent process in gastric carcinogenesis and could be useful for the detection of gastric neoplasia. | 22161215 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Our data suggest that the miRNA variants could affect the development of colorectal cancer in the Korean population. | 22161766 |
| Malignant neoplasm of urinary bladder, Breast Carcinoma | Epigenetic Alterations | The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes. | 22166496 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | This is the first report of associations between DNA repair gene miRNA-binding site SNPs with bladder and breast cancer risk and radiotherapy outcomes. | 22166496 |
| Primary malignant neoplasm | Epigenetic Alterations | Valproic acid (VPA) is a potential anticancer agent that belongs to a class of histone deacetylase (HDAC) inhibitors, targeting the epigenetic control of gene functions in cancer cells. | 22168970 |
| Stomach Carcinoma | Epigenetic Alterations | Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer. | 22169097 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Recent studies demonstrated that in several human malignancies aberrant expression profiles of circulating microRNAs (miRNAs) anticipate great cancer diagnostic potential. | 22169097 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Plasma DNA methylation of Wnt antagonists predicts recurrence of esophageal squamous cell carcinoma. | 22171134 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | To detect the effects of plasma DNA methylation of Wnt antagonists/inhibitors on recurrence of esophageal squamous cell carcinoma (ESCC). | 22171134 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNAs (miRNAs) are small, noncoding RNA molecules that can be down- or upregulated in colorectal cancer and have been associated to prognosis and response to treatment. | 22172905 |
| Primary malignant neoplasm | Epigenetic Alterations | A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. | 22172905 |
| Primary malignant neoplasm | Epigenetic Alterations | A set of 13 miRNAs is strongly associated with pCR and may represent a specific predictor of response to chemoradiotherapy in rectal cancer patients. | 22172905 |
| Malignant Neoplasms | Epigenetic Alterations | Widespread epigenetic alterations are characteristic of many cancers, yet few studies have systematically analyzed epigenetic alterations of neoplastic precursors. | 22173550 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent data suggest a link between blood leukocyte DNA methylation, and cancer risk. | 22173668 |
| Clinical Coordinator | Epigenetic Alterations | This reduced HSD17B1 expression was associated with significantly increased DNA methylation (p = 0.003) in the CpG rich region located in the 5 flanking sequence of the HSD17B1 gene in CRC in the proximal but not distal colon and rectum. | 22176788 |
| Clinical Coordinator | Epigenetic Alterations | Our results showed that reduced HSD17B1 expression can be associated with DNA methylation in the 5 flanking region of HSD17B1 in CRC from the proximal colon. | 22176788 |
| Neoplasms | Epigenetic Alterations | We are the first to demonstrate that miR-574-3p is a miRNA with tumor suppressor function and that MESDC1 (which has a potential oncogenic function in BC) may be targeted by miR-574-3p. | 22179486 |
| Stomach Carcinoma, Carcinogenesis, Cessation of life | Epigenetic Alterations | Gastric cancer (GC) is still a leading cause of cancer-related death worldwide, and environmental, genetic, and epigenetic DNA changes are involved in the process of gastric carcinogenesis. | 22179688 |
| Carcinogenesis, Inflammation | Epigenetic Alterations | If our subhypothesis regarding a mechanistic link from microorganism to carcinogenesis via inflammation and consequent aberrant DNA methylation is correct, then we should see hypermethylation of relevant genes associate with specific microbiomic profiles. | 22180460 |
| Primary lymphoma of conjunctiva | Epigenetic Alterations | MicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2. | 22183793 |
| Initiation | Epigenetic Alterations | Aberrant microRNA expression is implicated in cancer initiation and progression. | 22183793 |
| Primary lymphoma of conjunctiva | Epigenetic Alterations | We demonstrated that miRNAs were dysregulated in conjunctival MALT lymphoma, and dysregulation of the miR-200 family could be involved in the pathogenesis and progression of the disease. | 22183793 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNA expression profiles may be promising biomarkers for diagnosis and assessment of the prognosis of cancer patients. | 22198701 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is one of major factors in cancer progression. | 22199344 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran. | 22207181 |
| MIR122 gene, Hepatitis B, Chronic | Epigenetic Alterations | MicroRNA-122 is a liver specific microRNA and is elevated in the sera of patients with chronic hepatitis C virus infection. | 22209627 |
| Acute leukemia | Epigenetic Alterations | Distinctive microRNA signature is associated with the diagnosis and prognosis of acute leukemia. | 22209839 |
| Acute leukemia | Epigenetic Alterations | MicroRNAs (miRNAs) are of great importance in pathogenesis, diagnosis and prognosis of acute leukemia (AL). | 22209839 |
| Malignant neoplasm of stomach | Epigenetic Alterations | We examined the genetic and epigenetic alterations of the PDCD4 gene as well as the expression of PDCD4 protein in gastric cancers. | 22212233 |
| Malignant neoplasm of stomach | Epigenetic Alterations | miRNA-21 overexpression was frequently detected in gastric cancers (31 of 46, 67.4%), and there was a significant inverse correlation between miRNA-21 and PDCD4 protein expression (P = 0.029), but not between miRNA-21 and PDCD4 mRNA expression. | 22212233 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Our data suggest that overexpression of miRNA-21 and reduced or loss of PDCD4 expression may play a role in the development and progression of gastric cancers. | 22212233 |
| Cholangiocarcinoma | Epigenetic Alterations | Ars2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing microRNA-21. | 22213145 |
| Carcinoma of lung, Lung Neoplasms | Epigenetic Alterations | In adjacent histologically normal lung from lung cancer patients (n = 120), low levels of DNA methylation of the CYP1A1 enhancer were related to high levels of smoking-induced hydrophobic DNA adduct (p < 0.03), and to the presence of TP53 or K-ras mutations in the corresponding lung tumors (p < 0.03). | 22213191 |
| Primary malignant neoplasm | Epigenetic Alterations | In vitro, using a panel of cultured human lung cells, we found hypermethylation of the CYP1A1 enhancer in cancer cell lines and an inverse correlation between DNA methylation and mRNA levels (Spearman r = -0.53; p = 0.003). | 22213191 |
| Carcinogenesis | Epigenetic Alterations | Altogether, our results indicated that low levels of DNA methylation of the CYP1A1 enhancer in histologically normal human lung were associated with high CYP1A1 mRNA levels and with smoking-induced genetic alterations; thus, it may play a role in the initiation of lung carcinogenesis. | 22213191 |
| Intrahepatic Cholangiocarcinoma, Liver carcinoma | Epigenetic Alterations | Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. | 22213236 |
| Hepatocarcinogenesis, Hepatobiliary Disorder | Epigenetic Alterations | Dysregulation of microRNAs is involved in liver disease, especially hepatocarcinogenesis. | 22213236 |
| Malignant Neoplasms | Epigenetic Alterations | Genomic and epigenetic alterations of the gene encoding transcription factor AP-2 epsilon (TFAP2E) are common in human cancers. | 22216841 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations of TFAP2E were independent of mutations in key regulatory cancer genes, microsatellite instability, and other genes that affect fluorouracil metabolism. | 22216841 |
| Lung Neoplasms | Epigenetic Alterations | Similar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposure. | 22217548 |
| Malignant Neoplasms | Epigenetic Alterations | Low concentrations of EM66 found in malignant tumors are associated with reduced expression and production of SgII and SgII-derived peptides that could be ascribed to a decrease in SgII gene transcription, probably linked to p-CREB down-regulation, and to lower PC levels. | 22217803 |
| Pancreatic carcinoma, melanoma | Epigenetic Alterations | In pancreatic cancer and melanoma, CXCR4 expression is regulated by DNA methylation within its promoter region. | 22220212 |
| Breast Carcinoma | Epigenetic Alterations | Loss of DNA methylation in the CXCR4 promoter was detected in 67% of the breast cancer analyzed. | 22220212 |
| Breast Carcinoma | Epigenetic Alterations | These findings suggest that the DNA methylation status of both CXCR4 and CXCL12 genes could be used as a biomarker for prognosis in breast cancer. | 22220212 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic changes of CXCR4 and its ligand CXCL12 as prognostic factors for sporadic breast cancer. | 22220212 |
| Colorectal Carcinoma | Epigenetic Alterations | The contribution of chromosomal instability, microsatellite instability, and epigenetic instability to the development of synchronous colorectal carcinomas is controversial. | 22228162 |
| Colorectal Carcinoma, Neoplasms | Epigenetic Alterations | Our findings suggest that microsatellite instability plays a more important role than does epigenetic instability in the development of synchronous colorectal cancers, and that information regarding concordant or discordant microsatellite instability status between individual tumors might help to predict clinical outcome of synchronous colorectal cancers. | 22228162 |
| Glioblastoma | Epigenetic Alterations | MGMT is involved in direct DNA repair exerted by cleavage of mutagenic alkyl adducts within DNA, and its epigenetic silencing confers susceptibility to DNA-damaging alkylating agents in glioblastomas and melanomas. | 22228432 |
| Breast Carcinoma | Epigenetic Alterations | In this study we have mapped the promoters of 93 breast cancer-associated miRNAs, and then looked for associations between DNA methylation of 15 of these promoters and miRNA expression in breast cancer cells. | 22231446 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation of both P1 and P2 was inversely associated with miR-200b expression in eight out of nine breast cancer cell lines, and in vitro methylation of both promoters repressed their activity in reporter assays. | 22231446 |
| Breast Carcinoma | Epigenetic Alterations | These data suggest an association between miR-200b regulation and breast cancer subtype and a potential use of DNA methylation of miRNA promoters as a component of a suite of breast cancer biomarkers. | 22231446 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer. | 22231446 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Although miRNAs have been implicated in cancer, including breast cancer, the regulation of miRNA transcription and the role of defects in this process in cancer is not well understood. | 22231446 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genetic and epigenetic changes have correlation with specific stages of polyp-adenocarcinoma progression and colorectal cancer histopathological changes. | 22234098 |
| gastrointestinal | Epigenetic Alterations | Control of epigenetic changes using histone deacetylase inhibitors (HDACi) is thought to be a promising target in therapy of gastrointestinal (GI) cancer. | 22234637 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. | 22234685 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNAs (miRNAs) play a key role in chronic lymphocytic leukemia as well as in normal B cells. | 22234685 |
| Neoplasms | Epigenetic Alterations | 5-Methylcytosine (5 mC) in genomic DNA has important epigenetic functions in embryonic development and tumor biology. | 22234893 |
| Liver carcinoma | Epigenetic Alterations | Genome-wide DNA methylation profiles in hepatocellular carcinoma. | 22234943 |
| Malignant neoplasm of liver, Hollings Cancer Center | Epigenetic Alterations | Alterations in DNA methylation frequently occur in hepatocellular cancer (HCC). | 22234943 |
| cervical cancer, Neoplasms | Epigenetic Alterations | Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion. | 22237456 |
| Malignant Neoplasms, cervical cancer | Epigenetic Alterations | microRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancer patients has not been established. | 22237456 |
| cervical cancer | Epigenetic Alterations | The expression of microRNA-218 was detected in the sera of 90 cervical cancer patients and 50 normal age-matched women by quantitative real-time PCR. | 22237456 |
| Primary malignant neoplasm | Epigenetic Alterations | In the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001). | 22237456 |
| Cervical Adenocarcinoma, Metastasis | Epigenetic Alterations | Moreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis. | 22237456 |
| cervical cancer, Neoplasms | Epigenetic Alterations | microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion. | 22237456 |
| Malignant tumor of colon | Epigenetic Alterations | DNA methylation biomarker candidates for early detection of colon cancer. | 22238052 |
| Primary malignant neoplasm | Epigenetic Alterations | Many researchers have been looking for potential epigenetic therapeutic targets in cancer using gene expression profiling with DNA microarray approaches. | 22238052 |
| palladium | Epigenetic Alterations | We found decreased methylation of the cytochrome P450 2E1 gene and increased expression of CYP2E1 messenger RNA in PD patients brains, suggesting that epigenetic variants of this cytochrome contribute to PD susceptibility. | 22238121 |
| Malignant Neoplasms, Adrenal Gland Pheochromocytoma | Epigenetic Alterations | The microRNA expression changes associated with malignancy and SDHB mutation in pheochromocytoma. | 22241719 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules with relevance as regulators of gene expression thereby affecting crucial processes in cancer development. | 22242178 |
| Breast Carcinoma | Epigenetic Alterations | We performed microarray-based miRNA profiling on whole blood of 48 early stage breast cancer patients at diagnosis along with 57 healthy individuals as controls. | 22242178 |
| MIR206 wt Allele | Epigenetic Alterations | The relative fold changes of the RT-qPCR validation were in line with the microarray data for both miRNAs, and statistically significant differences in miRNA-expression were found for miR-202. | 22242178 |
| Breast Carcinoma | Epigenetic Alterations | MiRNA profiling in whole blood has potential as a novel method for early stage breast cancer detection, but there are still challenges that need to be addressed to establish these new biomarkers in clinical use. | 22242178 |
| Primary malignant neoplasm | Epigenetic Alterations | MiRNAs offer great potential as biomarkers for cancer detection due to their remarkable stability in blood and their characteristic expression in many different diseases. | 22242178 |
| Breast Carcinoma | Epigenetic Alterations | This was followed by a real-time semi-quantitative Polymerase Chain Reaction (RT-qPCR) validation in a separate cohort of 24 early stage breast cancer patients from a breast cancer screening unit and 24 age matched controls using two differentially expressed miRNAs (miR-202, miR-718). | 22242178 |
| Breast Carcinoma | Epigenetic Alterations | Using the significance level of p<0.05, we found that 59 miRNAs were differentially expressed in whole blood of early stage breast cancer patients compared to healthy controls. | 22242178 |
| Breast Carcinoma | Epigenetic Alterations | Circulating micro-RNAs as potential blood-based markers for early stage breast cancer detection. | 22242178 |
| Colorectal Cancer Pathway | Epigenetic Alterations | A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer. | 22244828 |
| Primary malignant neoplasm | Epigenetic Alterations | Altered promoter DNA methylation, one of the most important molecular alterations in cancer, is proposed to correlate with deregulation of DNA methyltransferases, although the molecular mechanisms implicated are still poorly understood. | 22244828 |
| ovarian neoplasm | Epigenetic Alterations | Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients. | 22246208 |
| Malignant neoplasm of stomach | Epigenetic Alterations | Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: induction of promoter demethylation and histone modification causing inhibition of Wnt signaling. | 22246241 |
| Stomach Carcinoma | Epigenetic Alterations | Sodium butyrate (NaB) induced demethylation and histone modification at the promoter region of SFRP1/2 restoring the SFRP expression in human gastric cancer cells. | 22246241 |
| Stomach Carcinoma | Epigenetic Alterations | These data suggest that aberrant epigenetic modification of SFRP genes is one of the major mechanisms by which Wnt signaling is activated in human gastric cancer cells and sodium butyrate may modulate the SFRP1/2 expression through histone modification and promoter demethylation causing anti-tumor effects. | 22246241 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | However, to date the somatic epigenetic events that occur in head and neck squamous cell carcinoma (HNSCC) tumorigenesis have not been well-defined. | 22246327 |
| Neoplasms | Epigenetic Alterations | In summary, we have shown promoter hypermethylation of the tumor suppressor genes MGMT and RASSF1A in HNSCC, suggesting that this epigenetic inactivation of TSGs may play a role in the development of HNSCC. | 22246327 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-34a (miR-34a) can function as a tumor suppressor in some cancers through negative regulation of gene expression. | 22246523 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Tumor suppressor function of PGP9.5 is associated with epigenetic regulation in prostate cancer--novel predictor of biochemical recurrence after radical surgery. | 22246902 |
| Prostate Cancer Pathway | Epigenetic Alterations | We speculated that impaired regulation of PGP9.5 through epigenetic pathways is associated with the pathogenesis of prostate cancer. | 22246902 |
| S100A4 protein, human | Epigenetic Alterations | Epigenetic de novo methylation of CpG islands is an important event in malignant transformation. | 22248274 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | The goal of this study was to develop an assay to detect the colorectal cancer (CRC)-associated, circulation-derived, epigenetic DNA marker hypermethylated vimentin gene (mVIM) in the urine of patients with CRC. | 22251609 |
| Clinical Coordinator | Epigenetic Alterations | A potential urine test for CRC screening using epigenetic markers is discussed. | 22251609 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Genetic variations in epigenetic genes are predictors of recurrence in stage I or II non-small cell lung cancer patients. | 22252258 |
| Primary malignant neoplasm, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We assessed the association of 165 SNPs in selected epigenetic enzyme genes, DNA methyltransferases, and methyl-CpG-binding proteins with cancer recurrence in 467 patients with stage I or II NSCLC treated with either surgery alone (N = 340) or surgery plus (neo)-adjuvant chemotherapy (N = 127). | 22252258 |
| Troponin T, Cardiac Muscle | Epigenetic Alterations | We compared the diagnostic performance of high-sensitivity cardiac troponin T (hs-cTnT) and cardiac enriched microRNAs (miRNAs) in patients with MI. | 22252325 |
| Chest Pain | Epigenetic Alterations | miRNAs and hs-cTnT were already detectable in the plasma 1 h after onset of chest pain. | 22252325 |
| Malignant tumor of colon | Epigenetic Alterations | The epigenetic silencing of myopodin by hypermethylation was tested in colon cancer cells (n = 5) before and after azacitidine treatment. | 22252522 |
| Squamous cell carcinoma | Epigenetic Alterations | Aberrant DNA methylation of tumor-related genes in oral rinse: a noninvasive method for detection of oral squamous cell carcinoma. | 22252571 |
| SERPINB3 wt Allele | Epigenetic Alterations | Eight of the 13 genes had significantly higher levels of DNA methylation in samples from patients with OSCC than in controls. | 22252571 |
| Primary malignant neoplasm | Epigenetic Alterations | The use of microRNAs (miRNAs) as minimally-invasive biomarkers has opened new opportunities for the diagnosis of cancer, primarily because they exhibit tumor-specific expression profiles and have been commonly observed in blood of both cancer patients and healthy controls. | 22253921 |
| Cardiovascular Diseases, mercaptopurine | Epigenetic Alterations | Quantitative reverse transcription-polymerase chain reaction of miRNAs which have been associated with cardiovascular diseases also demonstrated significant differences in miRNA profiles between platelets and their MP. | 22258631 |
| mercaptopurine | Epigenetic Alterations | Notably, the main fraction of miRNA in plasma was localized in MP. | 22258631 |
| Coronary Artery Disease, mercaptopurine | Epigenetic Alterations | Furthermore, miRNA profiles of MP differed significantly between patients with stable and unstable coronary artery disease. | 22258631 |
| mercaptopurine | Epigenetic Alterations | miRNA profiles of MP are significantly different from their maternal cells, indicating an active mechanism of selective packaging from cells into MP. | 22258631 |
| Cardiovascular Diseases | Epigenetic Alterations | Circulating microRNAs (miRNAs) have attracted major interest as biomarkers for cardiovascular diseases. | 22258631 |
| mercaptopurine | Epigenetic Alterations | We hypothesized that microparticles (MP) represent protective transport vehicles for miRNAs and that these are specifically packaged by their maternal cells. | 22258631 |
| Cardiovascular Diseases, mercaptopurine | Epigenetic Alterations | Circulating MP represent transport vehicles for large numbers of specific miRNAs, which have been associated with cardiovascular diseases. | 22258631 |
| Neoplasms | Epigenetic Alterations | Epigenetic inactivation of these three important glioma-associated genes was analyzed in paired biopsy samples from 18 patients with tumour recurrence. | 22264301 |
| Neoplasms | Epigenetic Alterations | Tumor-specific alterations of DNA methylation in circulating DNA have been associated with tumor burden and malignant progression. | 22265839 |
| Primary malignant neoplasm | Epigenetic Alterations | A wealth of information indicating the potential use of DNA methylation in circulating DNA for cancer screening, prognosis and monitoring of the efficacy of anticancer therapies has emerged. | 22265839 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins. | 22266187 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Frequent downregulation of microRNA-449a (miR-449a) was detected in 14 human bladder cancer tissues. | 22266187 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Tumor suppressive microRNA-133a regulates novel targets: moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma. | 22266319 |
| Malignant Neoplasms, Metastasis | Epigenetic Alterations | Recently, many studies suggest that microRNAs (miRNAs) contribute to the development, invasion and metastasis of various types of human cancers. | 22266319 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Prognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes stage of colorectal cancer patients. | 22267128 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Down-regulation of the novel tumor suppressor gene programmed cell death 4 (PDCD4) was demonstrated in several types of cancer and regulation by micro-RNA is gaining attention. | 22267128 |
| Fibrosis, Liver | Epigenetic Alterations | MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis. | 22267590 |
| Malignant neoplasm of liver | Epigenetic Alterations | MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. | 22267590 |
| Chronic liver disease, Fibrosis, Liver | Epigenetic Alterations | To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. | 22267590 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development. | 22269326 |
| Admitting diagnosis | Epigenetic Alterations | Increasing evidence indicates epigenetic modifications in LOAD brains, and many of the environmental factors associated with AD risk, such as heavy metals and dietary factors, are able to modify the epigenome. | 22272627 |
| Clinical Coordinator | Epigenetic Alterations | We detected 4 miRNAs (miR-143, miR-145, miR-21, and miR-106a) in the stool samples of 38 CRC patients and 13 healthy individuals. | 22273643 |
| Clinical Coordinator | Epigenetic Alterations | The detection of fecal miRNAs is a potential method for CRC diagnosis or screening. | 22273643 |
| Breast Carcinoma | Epigenetic Alterations | Effects of oestrogen on microRNA expression in hormone-responsive breast cancer cells. | 22274890 |
| Breast Carcinoma | Epigenetic Alterations | Here, we analysed changes in miRNA expression in response to oestrogen in hormone-responsive breast cancer MCF-7 and ZR-75.1 cells by microarray-mediated expression profiling. | 22274890 |
| Breast Carcinoma | Epigenetic Alterations | Results show that miRNAs modulated by ERa represent a novel genomic pathway to impact oestrogen-dependent processes that affect hormone-responsive breast cancer cell behaviour. | 22274890 |
| Clinical Coordinator, Carcinogenesis, Colorectal Cancer Pathway | Epigenetic Alterations | Considering the important role of miRNAs in carcinogenesis, it is hypothesized here that these SNPs could also affect the individual risk of colorectal cancer (CRC). | 22282400 |
| Colorectal Cancer Pathway | Epigenetic Alterations | UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression. | 22286757 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | UHRF1 is emerging as a cofactor that coordinates the epigenetic silencing of tumor suppressor genes, but its role in CRC remains elusive. | 22286757 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma. | 22286769 |
| Meningioma | Epigenetic Alterations | Cytogenetic, molecular and epigenetic changes are all known to take place in the pathogenesis of meningiomas. | 22288845 |
| Carcinogenesis, Metastasis | Epigenetic Alterations | The association of GATA5 hypermethylation with metastasis and progression-free survival of patients indicates that epigenetic alterations of GATA5 participate in renal cell carcinogenesis. | 22289415 |
| Liver carcinoma | Epigenetic Alterations | Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression. | 22289527 |
| Invasive Malignant Neoplasm, Metastasis | Epigenetic Alterations | Increasing evidence suggests that large intervening non-coding RNAs (lincRNAs) regulate key pathways in cancer invasion and metastasis. | 22289527 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Increased expression of microRNA-21and its association with chemotherapeutic response in human colorectal cancer. | 22289545 |
| Cytogenetically normal acute myeloid leukemia, Leukemia, Myelocytic, Acute | Epigenetic Alterations | To determine the frequency of DNMT3A mutations, their associations with clinical and molecular characteristics and outcome, and the associated gene- and microRNA-expression signatures in primary cytogenetically normal acute myeloid leukemia (CN-AML). | 22291079 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Low accuracy of gene- and microRNA-expression signatures in predicting DNMT3A mutation status suggested that the role of these mutations in AML remains to be elucidated. | 22291079 |
| diabetic | Epigenetic Alterations | DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. | 22293752 |
| diabetic | Epigenetic Alterations | We uncovered 276 CpG loci affiliated to promoters of 254 genes displaying significant differential DNA methylation in diabetic islets. | 22293752 |
| diabetic, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Together, our findings offer new insights into the intricate mechanisms of T2D pathogenesis, underscore the important involvement of epigenetic dysregulation in diabetic islets and may advance our understanding of T2D aetiology. | 22293752 |
| Breast Carcinoma | Epigenetic Alterations | The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer. | 22294488 |
| Breast Carcinoma | Epigenetic Alterations | Our results demonstrate alterations in miRNA expression at different stages of disease progression in breast cancer, and suggest a direct involvement of the miR-200 family and miR-9 in the metastatic process. | 22294488 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | In recent years, the involvement of microRNAs (miRNAs) in cancer has become apparent, and the objective of this study was to identify miRNAs associated with breast cancer progression. | 22294488 |
| Acoustic Neuroma | Epigenetic Alterations | Genetic and epigenetic alterations of the NF2 gene in sporadic vestibular schwannomas. | 22295085 |
| Primary malignant neoplasm | Epigenetic Alterations | In addition to genetic changes, epigenetic events, as aberrant DNA methylation and histone modification, are responsible for cancer development. | 22297548 |
| Neoplasms | Epigenetic Alterations | Many tumour suppressor genes are inactivated by DNA hypermethylation, which could be utilized for identification of new epigenetic biomarkers. | 22297548 |
| Malignant Neoplasms | Epigenetic Alterations | Circulating microRNA (miRNAs) have been shown to have the potential as noninvasive diagnosis markers in several types of cancers. | 22298030 |
| Prostate Cancer Pathway | Epigenetic Alterations | A panel of five circulating microRNAs as potential biomarkers for prostate cancer. | 22298030 |
| Aggressive behavior | Epigenetic Alterations | Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer. | 22298119 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | It is becoming increasingly evident that microRNAs (miRNAs) are associated with the development and progression of prostate cancer (PCa). | 22298119 |
| CHOANAL ATRESIA, POSTERIOR, MIR20A gene | Epigenetic Alterations | Four miRNAs (miR-20a, miR-21, miR-145, and miR-221) could also distinguish high versus low risk in PCa patients by DAmico score with an AUC of 0.824. | 22298119 |
| Aggressive behavior, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | These preliminary data suggest that altered plasma miRNAs may be useful predictors to distinguish PCa patients with varied aggressiveness. | 22298119 |
| Malignant tumor of colon, Primary malignant neoplasm | Epigenetic Alterations | We have compared DNA methylation in normal colon mucosa between patients with colon cancer and patients without cancer. | 22300984 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic differences in normal colon mucosa of cancer patients suggest altered dietary metabolic pathways. | 22300984 |
| Carcinoma | Epigenetic Alterations | A third miRNA, miR-375, showed marked downregulation exclusively in EACs and in none of the BM or HGD lesions, suggesting its association with progression to invasive carcinoma. | 22302717 |
| Barrett Esophagus | Epigenetic Alterations | The microRNAs, MiR-31 and MiR-375, as candidate markers in Barretts esophageal carcinogenesis. | 22302717 |
| Barrett Esophagus | Epigenetic Alterations | Taken together, we propose miR-31 and -375 as novel candidate microRNAs specifically associated with early- and late-stage malignant progression, respectively, in Barretts esophagus. | 22302717 |
| Barrett Esophagus, Dysplasia | Epigenetic Alterations | We then assessed the 26 EAC-derived miRNAs in laser microdissected biopsy pairs of Barretts metaplasia (BM)/nSQ (n = 15), and high-grade dysplasia (HGD)/nSQ (n = 14) by qPCR, to map the timing of deregulation during progression from BM to HGD and to EAC. | 22302717 |
| Hepatitis C | Epigenetic Alterations | Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection. | 22307176 |
| Splenic Marginal Zone B-Cell Lymphoma | Epigenetic Alterations | Unsupervised hierarchical clustering of miRNA expression profiles demonstrated a distinct signature of SMZL compared with the normal splenic marginal zone. | 22307176 |
| Splenic Marginal Zone B-Cell Lymphoma, Neoplasms | Epigenetic Alterations | Furthermore, we identified miR-26b, a miRNA known to have tumor suppressive properties, as significantly downregulated in SMZL arising in HCV-positive patients (P=0.0016). | 22307176 |
| Splenic Marginal Zone B-Cell Lymphoma | Epigenetic Alterations | In conclusion, there is a characteristic dysregulation of miRNA expression in SMZL with a possible implication in its molecular tumorigenesis. | 22307176 |
| Neoplasms | Epigenetic Alterations | Supervised analysis revealed differentially expressed miRNAs, including miRNAs with previously recognized tumor suppressive or oncogenic potential. | 22307176 |
| Splenic Marginal Zone B-Cell Lymphoma | Epigenetic Alterations | Five miRNAs were found significantly overexpressed in SMZL, including miR-21, miR-155 and miR-146a, whereas seven miRNAs showed significantly reduced expression, including miR-139, miR-345, miR-125a and miR-126. | 22307176 |
| Malignant neoplasm of kidney | Epigenetic Alterations | microRNA-155 silencing inhibits proliferation and migration and induces apoptosis by upregulating BACH1 in renal cancer cells. | 22307849 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma. | 22311119 |
| Malignant Neoplasms | Epigenetic Alterations | The microRNA-200 (miR-200) family has been reported to induce epithelial differentiation and suppress epithelial-mesenchymal transition (EMT) by inhibiting translation of zinc finger E-box-binding homeobox (ZEB) 1 and 2 mRNAs in several types of cancers. | 22311119 |
| Chronic sinusitis | Epigenetic Alterations | Epigenetics of chronic rhinosinusitis and the role of the eosinophil. | 22311846 |
| Primary malignant neoplasm | Epigenetic Alterations | Oncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling. | 22318752 |
| S100A4 protein, human | Epigenetic Alterations | The miRNA participates in a variety of biologic processes, and dysregulation of miRNA is associated with malignant transformation. | 22318752 |
| Primary malignant neoplasm | Epigenetic Alterations | There were 23 miRNAs found with considerably differential expressions between six oral cancer cell lines and five lines of normal oral keratinocytes, in which, 10 miRNAs showed the highest significant difference after independent examination by reverse transcription quantitative PCR. | 22318752 |
| Malignant neoplasm of mouth | Epigenetic Alterations | In conclusion, we have identified at least 10 miRNAs significantly associated with oral cancer, including the most elevated miR-10b. | 22318752 |
| Liver carcinoma | Epigenetic Alterations | Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. | 22318941 |
| Liver neoplasms, Hollings Cancer Center | Epigenetic Alterations | The expression of microRNA (miR)-23a, a candidate miR targeting PGC-1a and G6PC, was up-regulated in the mouse liver tumors as well as in primary human HCC. | 22318941 |
| Malignant Neoplasms, DICER1 protein, human | Epigenetic Alterations | Dicer and Drosha are the main regulators of miRNA biogenesis, and deregulation of their expression has been indicated as a possible cause of miRNA alterations observed in various cancers. | 22320315 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Alterations in microRNAs (miRNAs) expression have been proposed to play a role in CLL pathogenesis. | 22320315 |
| Neoplasms | Epigenetic Alterations | DNA methylation of CpG islands within the promoters of specific genes may play roles in tumor initiation and progression. | 22320963 |
| Neoplasms | Epigenetic Alterations | The clinical significance and tumor suppressive effect of miR-125a-3p, as well as previously reported miR-125a-5p, suggest that the functional role of another strand of the mature form miRNA cannot be ignored, at least in miR-125a biogenesis. | 22322911 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells. | 22322955 |
| Gastric Adenocarcinoma | Epigenetic Alterations | MicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma. | 22325466 |
| Neoplasms | Epigenetic Alterations | Recent evidence indicates that many miRNAs function as oncogenes or tumor suppressors by negatively regulating their target genes. | 22325466 |
| Neoplasms | Epigenetic Alterations | DNA methylation of HIC1 was analysed in a total of 98 tumor and 70 tumor adjacent normal specimens. | 22327210 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are a class of small non-coding RNAs of 19-25 nt and play important roles in gene regulation in human cancers. | 22331473 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer. | 22331473 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The purpose of this study is to identify miRNA expression profiles that would better predict prognosis of stage I NSCLC. | 22331473 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MiRNAs extracted from 527 stage I NSCLC patients were profiled on the human miRNA expression profiling v2 panel (Illumina). | 22331473 |
| Squamous cell carcinoma, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | MiRNA expression patterns between lung adenocarcinoma and squamous cell carcinoma differed significantly with 171 miRNAs, including Let-7 family members and miR-205. | 22331473 |
| Metastasis | Epigenetic Alterations | Ten miRNAs associated with brain metastasis were identified including miR-145*, which inhibit cell invasion and metastasis. | 22331473 |
| Adenocarcinoma, Non-Small Cell Lung Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | The first contained 34 miRNAs derived from 357 stage I NSCLC patients independent of cancer subtype, whereas the second containing 27 miRNAs was adenocarcinoma specific. | 22331473 |
| fibrogenesis | Epigenetic Alterations | Computational modeling approaches further highlight a potentially important link between HCV-associated oxidative stress and epigenetic regulatory mechanisms impacting on liver fibrogenesis. | 22331615 |
| ovarian neoplasm | Epigenetic Alterations | [Expression and significance of microRNAs in the p53 pathway in ovarian cancer cells and serous ovarian cancer tissues]. | 22340095 |
| ovarian neoplasm | Epigenetic Alterations | Mutant p53 ovarian cancer cell line SKOV3.ipl cells were transfected with pre-microRNAs and the cell-cycle changes were detected. | 22340095 |
| Malignant neoplasm of ovary, Neoplasms | Epigenetic Alterations | This study demonstrates that the p16 gene plays a role in the progression of human ovarian cancers and the blood DNA methylation of p16 gene promoter region is a weak predictor of tumor tissue methylation status. | 22344043 |
| myocardial injury | Epigenetic Alterations | Circulating microRNAs are promising new biomarkers of myocardial injury. | 22344502 |
| Carcinogenesis | Epigenetic Alterations | Recently, researchers have found that microRNAs play several important roles in carcinogenesis. | 22344713 |
| Primary malignant neoplasm | Epigenetic Alterations | The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in womens cancer. | 22346766 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation is an important cancer hallmark, yet the dynamics of DNA methylation changes in human carcinogenesis remain largely unexplored. | 22346766 |
| Malignant Neoplasms | Epigenetic Alterations | Moreover, the role of DNA methylation for prediction of clinical outcome is still uncertain and confined to specific cancers. | 22346766 |
| Malignant Neoplasms | Epigenetic Alterations | Here we perform the most comprehensive study of DNA methylation changes throughout human carcinogenesis, analysing 27,578 CpGs in each of 1,475 samples, ranging from normal cells in advance of non-invasive neoplastic transformation to non-invasive and invasive cancers and metastatic tissue. | 22346766 |
| MIR20A gene | Epigenetic Alterations | The relative concentrations of four circulating microRNAs (miR-19a, miR-20a, miR-21, and miR-214) in blood serum were measured by TaqMan MicroRNA assays. | 22350790 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNAs play a role in breast cancer development and progression by post-transcriptional repression of the expression of important genes, such as the tumor suppressor gene phosphatase and tensin homolog (PTEN). | 22350790 |
| Liver carcinoma | Epigenetic Alterations | Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma. | 22351518 |
| Hollings Cancer Center | Epigenetic Alterations | Epigenetic deregulation of the genes encoding the secreted frizzled-related proteins (sFRPs), the Wnt signalling antagonists, has been linked with aberrant hyperactivation of the Wnt signalling in HCC cells; however, the precise underlying mechanism remains elusive. | 22351518 |
| Malignant neoplasm of liver, Hollings Cancer Center | Epigenetic Alterations | We investigated the methylation profiles of Wnt antagonists in liver samples of different stages of HCC development and liver cancer cell lines and studied the functional impact of aberrant epigenetic silencing of sFRPs on the canonical Wnt pathway and cell viability. | 22351518 |
| Thyroid Gland | Epigenetic Alterations | A panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration. | 22351693 |
| Bipolar Disorder | Epigenetic Alterations | Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients with BDI and BDII. | 22353757 |
| Bipolar Disorder | Epigenetic Alterations | The etiology of bipolar disorder (BD) is still poorly understood, involving genetic and epigenetic mechanisms as well as environmental contributions. | 22353757 |
| Fibrosis Assessment | Epigenetic Alterations | Several miRNAs that have critical roles in tissue fibrosis and ECM metabolism have been reported. | 22358059 |
| Keloid | Epigenetic Alterations | However, regulation and function of miRNAs in keloid remain to be explored. | 22358059 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients. | 22360506 |
| Carcinogenesis | Epigenetic Alterations | Altered expression of specific microRNAs (miRNA) is known to occur during colorectal carcinogenesis. | 22362069 |
| Colorectal Carcinoma | Epigenetic Alterations | However, little is known about the genome-wide alterations in miRNA expression during the neoplastic progression of primary colorectal cancers. | 22362069 |
| Primary malignant neoplasm | Epigenetic Alterations | We identified a seven-miRNA expression signature that differentiated stage I and stage IV primary colon cancers. | 22362069 |
| Malignant tumor of colon | Epigenetic Alterations | We transfected HCT-116, a highly invasive colon cancer cell line, with corresponding downregulated miRNA and demonstrated that overexpression of three miRNA (miR200c*, miR143*, and miR424*) significantly abrogated invasive potential. | 22362069 |
| Neoplasms | Epigenetic Alterations | We have identified a seven-miRNA signature that is associated with metastatic potential in the primary tumor. | 22362069 |
| Neoplasms | Epigenetic Alterations | Forced overexpression of three downregulated miRNA resulted in attenuation of in vitro invasion, suggesting direct tumor suppressive function and further supporting the biological importance of complementary strand miRNA. | 22362069 |
| Adenocarcinoma of colon | Epigenetic Alterations | Complementary strand microRNAs mediate acquisition of metastatic potential in colonic adenocarcinoma. | 22362069 |
| Triple Negative Breast Neoplasms | Epigenetic Alterations | The epigenetic silencing of the estrogen receptor (ER) by hypermethylation of the ESR1 promoter is seen predominantly in triple-negative breast cancers in Indian women. | 22362381 |
| Triple-Negative Breast Cancer Finding, Neoplasms | Epigenetic Alterations | While the proportion of hypermethylated tumors are lower in this study than that estimated using MSP, our results support the notion of increased epigenetic deregulations in ER-negative tumors in general and TN tumors in particular. | 22362381 |
| Malignant Neoplasms, Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | The deregulation of microRNA (miRNA) is frequently associated with a variety of cancers, including hepatocellular carcinoma (HCC). | 22362728 |
| Hollings Cancer Center | Epigenetic Alterations | Therefore, miR-138 may serve as a useful therapeutic agent for miRNA-based HCC therapy. | 22362728 |
| Breast Carcinoma | Epigenetic Alterations | Identification of DNA methylation biomarkers is a field that provides potential for improving the clinical process of breast cancer diagnosis. | 22366991 |
| Primary Neoplasm, Breast Carcinoma | Epigenetic Alterations | Interestingly, DNA methylation of a novel gene OTP was detected in adjacent normal tissues even 6 cm away from primary tumors, suggesting that OTP methylation may qualify as a biomarker for the early detection of breast cancer. | 22366991 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Decreased expression of repulsive guidance molecule member A by DNA methylation in colorectal cancer is related to tumor progression. | 22367090 |
| Colorectal Cancer Pathway | Epigenetic Alterations | However, the relationship between the expression levels and promoter DNA methylation status of RGMa and the clinical characteristics of colorectal cancer has not been previously reported. | 22367090 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients. | 22370716 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Mesenchymal stromal cells from myelodysplastic syndrome patients showed lower DICER1 (0.65+-0.08 vs. 1.91+-0.57; P=0.011) and DROSHA (0.62+-0.06 vs. 1.38+-0.29; P=0.009) gene expression levels, two relevant endonucleases associated to microRNA biogenesis, in comparison to normal myelodysplastic syndrome. | 22371183 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Furthermore, mesenchymal stromal cells from myelodysplastic syndrome patients showed an underlying microRNA repression compared to healthy controls. | 22371183 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Conclusions This is the first description of an impaired microRNA biogenesis in human mesenchymal stromal cells from myelodysplastic syndrome patients, where DICER1 and DROSHA gene and protein downregulation correlated to a gene and microRNA abnormal expression profile, validating the animal model results previously described. | 22371183 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients. | 22371183 |
| Breast Carcinoma | Epigenetic Alterations | Our purpose was to identify epigenetic markers of breast cancer risk, which can be reliably measured in peripheral blood and are amenable for large population screening. | 22371529 |
| Hollings Cancer Center | Epigenetic Alterations | However, the overexpression of microRNA-301a (miR-301a) has seldom been connected with tumorigenesis in HCC. | 22373864 |
| Malignant Neoplasms, Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | MiRNAs have been connected closely with the development of cancers such as hepatocellular carcinoma (HCC). | 22373864 |
| Primary malignant neoplasm | Epigenetic Alterations | We propose that this approach can be adopted for accurate analysis of other suitable circulating miRNA markers of different types of cancer. | 22374169 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Gene expression profiling (GEP) and miRNA expression profiling clearly differentiated pediatric DLBCL from BL, forming distinct clusters regardless of patient age. | 22374697 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The evaluation of WBC DNA methylation as a biomarker of cancer risk is of particular importance as peripheral blood is often available in prospective cohorts and easier to obtain than tumor or normal tissues. | 22374981 |
| Breast Carcinoma | Epigenetic Alterations | Together, our findings indicate that WBC DNA methylation levels at ATM could be a marker of breast cancer risk and further support the pursuit of epigenome-wide association studies of peripheral blood DNA methylation. | 22374981 |
| Clinical Coordinator, Carcinogenesis | Epigenetic Alterations | Colorectal (CRC) carcinogenesis through various morphological stages has been linked to several genetic and epigenetic changes. | 22376079 |
| Malignant Neoplasms, Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Primary malignant neoplasm | Epigenetic Alterations | Our expression signatures of human cancers including head and neck squamous cell carcinoma (HNSCC) demonstrated that downregulation of microRNA-133a (miR-133a) were frequently observed in cancer cells. | 22378351 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Novel molecular targets regulated by tumor suppressors microRNA-1 and microRNA-133a in bladder cancer. | 22378464 |
| Malignant neoplasm of urinary bladder, Primary malignant neoplasm, Best Case Imputation Technique | Epigenetic Alterations | Our expression signatures of human cancer including bladder cancer (BC) revealed that the expression of microRNA-1 (miR-1) and microRNA-133a (miR-133a) is significantly reduced in cancer cells. | 22378464 |
| Scleroderma | Epigenetic Alterations | TGF-b-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts. | 22379029 |
| Sample Size Calculation | Epigenetic Alterations | miR-196a inhibitor leads to the overexpression of type I collagen in normal fibroblasts, whereas overexpression of the miRNA resulted in the downregulation of type I collagen in SSc fibroblasts. | 22379029 |
| SF3B1 wt Allele | Epigenetic Alterations | Several genetic/epigenetic abnormalities are deeply associated with the pathogenesis of MDS. | 22382018 |
| SF3B1 wt Allele | Epigenetic Alterations | Here, we report that circulating cell-free DNAs from plasma and serum of patients with MDS can be used to detect genetic/epigenetic abnormalities. | 22382018 |
| Stomach Carcinoma | Epigenetic Alterations | H. pylori eradication improved miRNA dysregulation, but not in intestinal metaplastic glands or in the gastric mucosa of patients in a high-risk group for gastric cancer. | 22382634 |
| Stomach Carcinoma | Epigenetic Alterations | Many microRNAs (miRNAs) are differentially expressed in Helicobacter pylori-infected gastric mucosa and in gastric cancer tissue. | 22382634 |
| Stomach Carcinoma | Epigenetic Alterations | We aimed to compare the effect of H. pylori eradication on gastric mucosal miRNAs in subjects in a high-risk group for gastric cancer compared to controls. | 22382634 |
| Primary malignant neoplasm | Epigenetic Alterations | The expression of oncogenic miRNAs (miR-17/92 and the miR-106b-93-25 cluster, miR-21, miR-194, and miR-196) was significantly higher in the gastric mucosa of the cancer group than in the controls. | 22382634 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | MicroRNA-199a-5p is associated with hypoxia-inducible factor-1a expression in lungs from patients with COPD. | 22383663 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | However, the role of miRNAs associated with these genes in lungs from patients with COPD is unknown. | 22383663 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | These data suggest that miR-34a and miR-199a-5p contribute to the pathogenesis of COPD, and these miRNAs may also affect the HIF-1a-dependent lung structure maintenance program. | 22383663 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNA) have been implicated to play an important role in the pathogenesis of a variety of cancers. | 22386240 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The level of these miRNA targets in urine has the potential to be developed as noninvasive markers for bladder cancer. | 22386240 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Expression of microRNAs in the urine of patients with bladder cancer. | 22386240 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The urinary level of these miRNAs may be developed as noninvasive markers for bladder cancer. | 22386240 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Serum microRNA biomarkers for detection of non-small cell lung cancer. | 22389695 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Receiver operating characteristic curves (ROC) and area under the curve were used to identify differentially expressed miRNA pairs that could distinguish NSCLC from healthy controls. | 22389695 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Selected miRNA candidates were further validated in sera from an additional 55 NSCLC patients and 75 healthy controls. | 22389695 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Examination of miRNA expression levels in serum from a multi-institutional cohort of 50 subjects (30 NSCLC patients and 20 healthy controls) identified differentially expressed miRNAs. | 22389695 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Upon further testing on additional 130 subjects (55 NSCLC and 75 healthy controls), this miRNA pair predicted NSCLC with a specificity of 84% (95% CI 0.73-0.91), sensitivity of 100% (95% CI; 0.93-1.0), NPV of 100%, and PPV of 82%. | 22389695 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | A combination of two differentially expressed miRNAs miR-15b and miR-27b, was able to discriminate NSCLC from healthy controls with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 100% in the training set. | 22389695 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These data provide evidence that serum miRNAs have the potential to be sensitive, cost-effective biomarkers for the early detection of NSCLC. | 22389695 |
| Metabolic Syndrome X | Epigenetic Alterations | Epigenetic regulation of COMT may further influence the prevalence of metabolic syndrome in these patient populations. | 22391769 |
| Primary malignant neoplasm | Epigenetic Alterations | It has been suggested that the presence of single nucleotide polymorphisms (SNPs) in miRNAs can alter miRNA processing, expression, and/or binding to target mRNA and represent another type of genetic variability that can contribute to susceptibility to cancer development in humans. | 22393998 |
| Leukemia, Myelomonocytic, Chronic | Epigenetic Alterations | Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. | 22395470 |
| Myeloid Leukemia | Epigenetic Alterations | TET2 mutations are common in myeloid leukemia and were proposed to contribute to leukemogenesis through DNA methylation. | 22395470 |
| Leukemia, Myelomonocytic, Chronic, Myeloid Leukemia | Epigenetic Alterations | Using bisulfite pyrosequencing, global methylation measured by the LINE-1 assay and DNA methylation levels of 10 promoter CpG islands frequently abnormal in myeloid leukemia were not different between TET2 mutants and wild-type CMML cases. | 22395470 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The predictive value of microRNA-126 in relation to first line treatment with capecitabine and oxaliplatin in patients with metastatic colorectal cancer. | 22397399 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Global histone methylation levels may help to identify RCC patients with poor prognosis. | 22399607 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetics, particularly DNA methylation, has recently been shown to be important in breast cancer initiation. | 22402307 |
| Sample Size Calculation | Epigenetic Alterations | miR-129-5p, one of the downregulated microRNAs in SSc fibroblasts, increased due to IL-17A and mediated the a1(I) collagen reduction. | 22403442 |
| Neoplasms | Epigenetic Alterations | The miRNA levels in the different groups reflected pathological tumor progression. | 22406928 |
| Neoplasms | Epigenetic Alterations | An assay of serum miR-17-5p/20a levels showed that the levels of serum miRNAs were notably reduced in post-treated mice with tumor volume regression. | 22406928 |
| Stomach Carcinoma | Epigenetic Alterations | Clinicopathological and prognostic significance of microRNA-107 and its relationship to DICER1 mRNA expression in gastric cancer. | 22407237 |
| Invasive Malignant Neoplasm, Metastasis | Epigenetic Alterations | It is known that miRNA-107 (miR-107) promotes cancer invasion and metastasis. | 22407237 |
| Non-Small Cell Lung Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | The weak increase of both APIP and UACA mRNA levels in the 5-aza-2-deoxycytidine-treated NSCLC cells indicates that mechanisms other than DNA methylation are involved in the regulation of APIP and UACA gene expression in these cancer cells. | 22407486 |
| Liver carcinoma | Epigenetic Alterations | Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. | 22407776 |
| Hepatocarcinogenesis | Epigenetic Alterations | Epigenetic inactivation of a subset of TSGs plays a critical role in the earliest steps of hepatocarcinogenesis. | 22407776 |
| Carcinogenic Chlorinated Hydrocarbon, Hollings Cancer Center | Epigenetic Alterations | Furthermore, epigenetic inactivation of these genes in CHC provides a prognostic value for determining the risk for developing HCC later in life. | 22407776 |
| AMD1 wt Allele | Epigenetic Alterations | The evidence presented suggests that GSTM1 and GSTM5 undergo epigenetic repression in AMD RPE/choroid, which may increase susceptibility to oxidative stress in AMD retinas. | 22410570 |
| Liver Cirrhosis | Epigenetic Alterations | In contrast, alterations in serum levels of miR-652 were stage-independent, reflecting a concordant down-regulation of this miRNA in circulating monocytes of patients with liver cirrhosis, which was inducible by proinflammatory stimuli like bacterial lipopolysaccharide. | 22412969 |
| Liver Cirrhosis | Epigenetic Alterations | Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis. | 22412969 |
| Chronic liver disease | Epigenetic Alterations | Micro-RNAs (miRNAs) have recently emerged as crucial modulators of molecular processes involved in chronic liver diseases. | 22412969 |
| Liver Cirrhosis | Epigenetic Alterations | The few miRNAs with previously proposed roles in liver cirrhosis were identified in screening approaches on liver parenchyma, mostly in rodent models. | 22412969 |
| Prostate carcinoma | Epigenetic Alterations | Epigenetic down regulation of RASSF10 and its possible clinical implication in prostate carcinoma. | 22415519 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | This is the first study, which demonstrates the frequent epigenetic inactivation of RASSF10 in PCa and its implication in clinical symptoms of PCa. | 22415519 |
| Breast Diseases | Epigenetic Alterations | The DNA methylation level in 1,505 CpG-sites was similar in samples from patients with benign breast disorders and lymphogenous metastases. | 22416386 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | [Epigenetic aspects of early lymphogenic metastasis in breast cancer]. | 22416386 |
| Coronary Artery Disease, Hypercholesterolemia | Epigenetic Alterations | ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia. | 22419126 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | In conclusion, inactivation of TROP2 due to LOH or by DNA methylation may play an important role in lung cancer tumourigenicity through losing its suppressive effect on IGF-1R signalling and tumour growth. | 22419550 |
| Metabolic Diseases | Epigenetic Alterations | These novel associations between global LINE-1 DNA methylation and blood glycaemic and lipid profiles highlight a potential role for epigenetic biomarkers as predictors of metabolic disease and may be relevant to future diagnosis, prevention and treatment of this group of disorders. | 22422454 |
| Malignant neoplasm of urinary bladder, Carcinogenesis, Neoplasms | Epigenetic Alterations | Altered microRNA (miRNA) expression may occur early in bladder cancer and may play a role in carcinogenesis and tumor behavior. | 22426337 |
| Bladder Neoplasm | Epigenetic Alterations | We evaluated whether alterations in miRNA expression could improve disease stratification and outcome prognosis in bladder tumors and noninvasive diagnosis in urinary samples. | 22426337 |
| Carcinoma, Neoplasms | Epigenetic Alterations | Tumor miRNA expression by RT-qPCR correlated with tumor grade, size, and presence of carcinoma in situ for miR-222, recurrence (miR-222 and miR-143), progression (miR-222 and miR-143), disease-specific survival (miR-222), and overall survival (miR-222). | 22426337 |
| Bladder Neoplasm, Neoplasms | Epigenetic Alterations | Thus, bladder tumors were characterized by changes in miRNA expression that could aid in tumor stratification and clinical outcome prognosis, and miRNAs were detected in urinary specimens for noninvasive diagnosis. | 22426337 |
| Malignant tumor of colon, Neoplasms | Epigenetic Alterations | Tumor microRNA-29a expression and the risk of recurrence in stage II colon cancer. | 22426940 |
| Malignant tumor of colon | Epigenetic Alterations | There is emerging evidence for the prognostic role of various microRNA (miRNA) molecules in colon cancer. | 22426940 |
| Terminal illness | Epigenetic Alterations | The study population included 110 patients, 51 (46%) with stage I and 59 (54%) with stage II disease, who underwent curative colectomies between 1995 and 2005 without adjuvant therapy and for whom reliable miRNA expression data were available. | 22426940 |
| Clinical Coordinator | Epigenetic Alterations | In addition, we analyzed the DNA methylation of the sixth CTCF-binding site in the DMR of IGF2/H19 in 81 CRC patients using bisulfate sequencing. | 22427002 |
| Neoplasms | Epigenetic Alterations | Tumour genetic and epigenetic features differ by tumour location. | 22427238 |
| diabetic | Epigenetic Alterations | In conclusion, these findings show a dysregulation of miRNAs in HF, shedding light on the specific disease mechanisms differentiating diabetic patients. | 22427379 |
| Malignant neoplasm of kidney | Epigenetic Alterations | MicroRNA 15a, inversely correlated to PKCa, is a potential marker to differentiate between benign and malignant renal tumors in biopsy and urine samples. | 22429968 |
| Renal Cell Carcinoma | Epigenetic Alterations | An identical system can be identified in renal carcinomas, in which, after nuclear transmigration, PKCa binds directly to pri-miRNA 15a in the nucleus. | 22429968 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Conversely, miRNA 15a is up-regulated in RCC and down-regulated in oncocytoma. | 22429968 |
| Cystitis, Refractory Cytopenia of Childhood, Neoplasms | Epigenetic Alterations | Up-regulated miRNA 15a can be measured in urine from patients with RCC but is nearly undetectable in oncocytoma, other tumors, and urinary tract inflammation. | 22429968 |
| Disease | Epigenetic Alterations | Increasing evidence shows that single nucleotide polymorphisms (SNPs) or mutations in microRNAs (miRNAs) sequence may affect the processing and function of miRNAs and participate in the occurrence of diseases. | 22430032 |
| Pathology | Epigenetic Alterations | Association between the miRNA signatures in plasma and bronchoalveolar fluid in respiratory pathologies. | 22430188 |
| Carcinoma of lung, Malignant neoplasm of lung | Epigenetic Alterations | The measurement of miRNA expression through less invasive techniques such as plasma and serum have been suggested to analysis of several lung malignancies including lung cancer. | 22430188 |
| Respiration Disorders | Epigenetic Alterations | This finding supports that the miRNAs profiles obtained from different biological samples have to be carefully validated to link with respiratory diseases. | 22430188 |
| Neoplasms | Epigenetic Alterations | DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract. | 22430803 |
| Neoplasms | Epigenetic Alterations | This study identifies aberrant DNA methylation patterns in UADT cancers and suggests a potential mechanism by which environmental factors may deregulate key cellular genes involved in tumor suppression and contribute to UADT cancers. | 22430803 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | This profile demonstrates the potential of DNA methylation measured in blood for development of non-invasive applications for detection of head and neck cancer. | 22430805 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Monoallelic and biallelic deletions of 13q14.3 in chronic lymphocytic leukemia: FISH vs miRNA RT-qPCR detection. | 22431542 |
| Malignant Neoplasms | Epigenetic Alterations | A single nucleotide polymorphism located in the 3-untranslated region of the KRAS oncogene (KRAS variant; rs61764370) disrupts a let-7 miRNA binding and was recently reported to act as a genetic marker for increased risk of developing human cancers. | 22436609 |
| Dyspepsia | Epigenetic Alterations | Genetic polymorphism of pri-microRNA 325, targeting SLC6A4 3-UTR, is closely associated with the risk of functional dyspepsia in Japan. | 22438098 |
| Breast Carcinoma, Mammary Neoplasms | Epigenetic Alterations | microRNA expression signatures can differentiate normal and breast cancer tissues and can define specific clinico-pathological phenotypes in breast tumors. | 22438871 |
| Breast Carcinoma | Epigenetic Alterations | Importantly, the role of 43 of these microRNAs has not been previously reported in breast cancer, including several evolutionary conserved microRNA*, showing similar expression rates to that of their corresponding leading strand. | 22438871 |
| Carcinogenesis | Epigenetic Alterations | Pathway analysis identified that some biological process which are important in breast carcinogenesis are affected by the altered microRNA expression, including signaling through MAP kinases and TP53 pathways, as well as biological processes like cell death and communication, focal adhesion and ERBB2-ERBB3 signaling. | 22438871 |
| Breast Carcinoma | Epigenetic Alterations | Identification and pathway analysis of microRNAs with no previous involvement in breast cancer. | 22438871 |
| Neoplasms | Epigenetic Alterations | The expression of 14 microRNAs was replicated in an independent set of 55 tumors. | 22438871 |
| Breast Carcinoma | Epigenetic Alterations | Our data identified the altered expression of several microRNAs whose aberrant expression might have an important impact on cancer-related cellular pathways and whose role in breast cancer has not been previously described. | 22438871 |
| Mammary Neoplasms | Epigenetic Alterations | 130 miRNAs showed significant differential expression (adjusted P value = 0.05, Fold Change = 2) in breast tumors compared to the normal adjacent tissue. | 22438871 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Salivary rinses have been recently proposed as a valuable resource for the development of epigenetic biomarkers for detection and monitoring of head and neck squamous cell carcinoma (HNSCC). | 22438973 |
| SERPINB3 wt Allele, Metastasis | Epigenetic Alterations | This study demonstrates that downregulation of 7 miRNA associated with advanced stage, 6 miRNAs with metastasis and 2 with poor prognosis in SCCC. | 22438992 |
| Small cell carcinoma of the cervix, Metastasis | Epigenetic Alterations | Downregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix. | 22438992 |
| Neoplasm Metastasis | Epigenetic Alterations | Using the GeneCopoeia All-in-One(tm) Customized Human qPCR Primer Array, the expression profiles of 30 miRNAs associated with tumor metastasis was obtained from the formalin-fixed paraffin embedded samples of all 44 patients. | 22438992 |
| MicroRNA 105, SERPINB3 wt Allele, Federation of Gynecology and Obstetrics | Epigenetic Alterations | Seven miRNAs, has-let-7c, has-miR-10b, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p were significantly down-regulated in advanced stage SCCC patients (FIGO IB2-IV) compared to early stage SCCC patients (FIGOIB1). | 22438992 |
| MicroRNA 105, SERPINB3 wt Allele, Metastasis | Epigenetic Alterations | Among, downregulation of six miRNAs, has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p were significantly associated with lymph node metastasis and reduced survival in SCCC. | 22438992 |
| SERPINB3 wt Allele | Epigenetic Alterations | Functional analysis of these miRNAs may enhance our understanding of SCCC, as altered expression of specific miRNAs may regulate the metastatic pathway and provide novel targets for therapy. | 22438992 |
| Malignant Neoplasms, Breast Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) are small non-coding RNAs playing significant role in the pathogenesis of many cancers including breast cancer. | 22439831 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | Therefore, miRNAs are also potential prognostic and/or predictive biomarkers in triple-negative breast cancer patients. | 22439831 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been recently described as powerful circulating biomarkers in a wide range of solid cancers. | 22440013 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | We identified 30 miRNAs differentially expressed between serum of RCC patients and healthy controls: 19 miRNAs were up-regulated and 11 miRNAs were down-regulated in RCC patients. | 22440013 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Circulating miRNAs in serum are promising biomarkers in RCC. | 22440013 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Recent studies have shown that deregulated expression of microRNAs (miRNAs) contributes to the initiation and progression of PCa. | 22442719 |
| Aggressive behavior, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Among several known miRNAs, let-7 family appears to play a key role in the recurrence and progression of PCa by regulating CSCs; however, the mechanism by which let-7 family contributes to PCa aggressiveness is unclear. | 22442719 |
| Multiple Myeloma | Epigenetic Alterations | Circulating microRNA expression is associated with genetic subtype and survival of multiple myeloma. | 22447484 |
| Esophageal carcinoma | Epigenetic Alterations | To explore the epigenetic changes and the function of TFPI-2 in esophageal cancer. | 22449186 |
| Alzheimers Disease | Epigenetic Alterations | Genome-wide DNA methylation differences between late-onset Alzheimers disease and cognitively normal controls in human frontal cortex. | 22451312 |
| Alzheimers Disease", Loading Technique | Epigenetic Alterations | Evidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset Alzheimers disease (LOAD), but little has been done on a genome-wide scale to identify potential sites involved in disease. | 22451312 |
| Loading Technique | Epigenetic Alterations | Identification of epigenetic biomarkers of LOAD risk may allow for the development of novel diagnostic and therapeutic targets. | 22451312 |
| Primary malignant neoplasm | Epigenetic Alterations | Oncogenic miRNAs, including two miRNA clusters, miR-17-92a and miR-106b-25 cluster, were upregulated in cancer stromal tissues compared with normal stroma. | 22452939 |
| Primary malignant neoplasm | Epigenetic Alterations | Although further validation is required, the finding that stromal miRNA expression levels were associated with clinicopathologic factors suggests the possibility that miRNAs in cancer stroma are crucially involved in cancer progression. | 22452939 |
| Primary malignant neoplasm | Epigenetic Alterations | Oncogenic miRNAs were highly expressed in cancer stroma. | 22452939 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant expression of MicroRNAs is considered to participate in occurrence and progression of human cancers. | 22455393 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Claudin-6 is a candidate tumor suppressor gene in breast cancer, and has been shown to be regulated by DNA methylation and histone modification in breast cancer lines. | 22455563 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-372 is associated with poor prognosis in colorectal cancer. | 22456107 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Aberrant DNA methylation has been implicated in the development of hepatocellular carcinoma (HCC). | 22457049 |
| Neoplasms | Epigenetic Alterations | Meanwhile, the reduced expression of two miRNAs in tumor patient was supposed to have a trend of lymph node metastases. | 22457808 |
| Neoplasms | Epigenetic Alterations | It showed a significant correlation between these two miRNAs expression both in tissues and tumor cell lines. | 22457808 |
| Eyelid Sebaceous Gland Carcinoma | Epigenetic Alterations | Epigenetic inactivation of the E-cadherin gene in eyelid sebaceous gland carcinoma. | 22458737 |
| Eyelid Sebaceous Gland Carcinoma | Epigenetic Alterations | Epigenetic inactivation of the E-cadherin gene causes loss of membrane-bound E-cadherin and could contribute to the reduced disease-free survival in eyelid sebaceous gland carcinoma. | 22458737 |
| Coronary Artery Disease | Epigenetic Alterations | [The influence of statin therapy on circulating microRNA-92a expression in patients with coronary heart disease]. | 22464573 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | MicroRNA expression aids the preoperative diagnosis of pancreatic ductal adenocarcinoma. | 22466166 |
| Pancreatic Ductal Adenocarcinoma, Pancreas | Epigenetic Alterations | Pancreatic ductal adenocarcinomas show differential expression of miRNAs compared to benign pancreatic lesions. | 22466166 |
| Pancreas | Epigenetic Alterations | A select panel of miRNAs aids the distinction between pancreatic lesions in cytology specimens. | 22466166 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | These findings indicate that miR-378, miR-375, miR-422a and miR-215 play an important role in CRC as tumour suppressors, whereas miR-135b functions as an oncogene; both groups of miRNA contribute to CRC pathogenesis. | 22469014 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Identification and functional screening of microRNAs highly deregulated in colorectal cancer. | 22469014 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) constitute a robust regulatory network with post-transcriptional regulatory efficiency for almost one half of human coding genes, including oncogenes and tumour suppressors. | 22469014 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | We determined the expression profile of 667 miRNAs in colorectal cancer (CRC) tissues and paired non-tumoural tissues and identified 42 differentially expressed miRNAs. | 22469014 |
| Primary malignant neoplasm | Epigenetic Alterations | An altered expression of microRNAs (miRNAs) contributes both to the development of cancer and to the progression of the disease. | 22470130 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Malignant tumours and tumour cell lines have widespread deregulated expressions of miRNAs compared to normal tissues. | 22470130 |
| Glioblastoma Multiforme | Epigenetic Alterations | We show that the expression profiles of 10 miRNAs can distinguish primary from secondary glioblastoma types. | 22470130 |
| Glioblastoma | Epigenetic Alterations | In conclusion, the expression patterns of different miRNAs characterise primary and secondary glioblastomas. | 22470130 |
| SERPINB3 wt Allele | Epigenetic Alterations | Observational assessment of DNA copy number, miRNA, and RNA expression in primary and metastatic OSCC. | 22470160 |
| Metastasis | Epigenetic Alterations | Among these unique miRNAs, miR-140-3p, miR-29c, and miR-29a were differentially expressed in metastasis versus nonmetastatic samples and had a strong positive correlation with their DNA copy numbers and a negative correlation with the expression of their target genes. | 22470160 |
| Neoplasm Metastasis | Epigenetic Alterations | Results suggest that DNA copy number aberration may play a role in the dysregulation of some differentially expressed miRNAs in OSCC metastasis, warranting further investigation. | 22470160 |
| Stomach Carcinoma | Epigenetic Alterations | Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer. | 22470493 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Analysis of the DNA methylation profile of the CRY1 promoter in a subgroup of 57 patients revealed that CRY1 expression in LR CLL cells is silenced by aberrant promoter CpG island hypermethylation. | 22470559 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia. | 22470559 |
| Malignant Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | We also compared the CRY1 expression in CLL with other lymphoid malignancies and observed epigenetic silencing of CRY1 in a patient with B cell acute lymphoblastic leukemia (B-ALL). | 22470559 |
| Carcinoma of lung | Epigenetic Alterations | Expression of A/B/H blood group antigens was not detected in lung cancer tissues, which may have resulted from down-regulation of ABO/FUT2 gene transcription. | 22471454 |
| Carcinoma of lung | Epigenetic Alterations | Effects of ABO and FUT2 genetic transcription absence on ABH histo-blood group antigen expression in lung cancer patients. | 22471454 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer (CRC) patients; however, only a little is known about its functional role in CRC. | 22476768 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer. | 22476851 |
| Breast Carcinoma | Epigenetic Alterations | However, prognostic markers and the outcome prediction of the miRNA signature in breast cancer patients have not been comprehensively assessed. | 22476851 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent studies have suggested that specific microRNAs (miRNAs) may play important roles in the development of cancer cells. | 22476851 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The expression of heparanase and microRNA-1258 in human non-small cell lung cancer. | 22488243 |
| Mantle cell lymphoma | Epigenetic Alterations | Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis. | 22490335 |
| Mantle cell lymphoma, Medial collateral ligament | Epigenetic Alterations | miRNA deregulation has been implicated in the pathogenesis of mantle cell lymphoma (MCL). | 22490335 |
| Medial collateral ligament, Aggressive Non-Hodgkin Lymphoma | Epigenetic Alterations | We identified a 19-miRNA classifier that included 6 up-regulated miRNAs and 13 down regulated miRNA that was able to distinguish MCL from other aggressive lymphomas. | 22490335 |
| Medial collateral ligament, Lymphoma | Epigenetic Alterations | This miRNA classifier showed consistent results in formalin-fixed paraffin-embedded tissues and was able to distinguish cyclin D1-negative MCL from other lymphomas. | 22490335 |
| Medial collateral ligament, B Lymphoblastic Leukemia/Lymphoma | Epigenetic Alterations | A 26-miRNA classifier could distinguish MCL from small lymphocytic leukemia/lymphoma, dominated by 23 up-regulated miRNAs in MCL. | 22490335 |
| Medial collateral ligament | Epigenetic Alterations | Unsupervised hierarchical clustering of MCL patients demonstrated a cluster characterized by high expression of miRNAs from the polycistronic miR17-92 cluster and its paralogs, miR-106a-363 and miR-106b-25, and associated with high proliferation gene signature. | 22490335 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are non-coding RNAs that have been shown to be aberrantly expressed in several tumor types. | 22492279 |
| Neoplasms | Epigenetic Alterations | Of these miRNAs, miR-22 as tumor suppressor has been shown to play a crucial role in human carcinogenesis. | 22492279 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients. | 22492545 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) constitute a robust regulatory network with posttranscriptional regulatory efficiency for almost one-half of human coding genes, including oncogenes and tumor suppressors. | 22492545 |
| Neoplasms, Refractory Cytopenia of Childhood | Epigenetic Alterations | To identify potential prognostic miRNAs, we analyzed expression profiles in tumors of different prognostic groups of RCC patients. | 22492545 |
| Neoplasms, Refractory Cytopenia of Childhood | Epigenetic Alterations | We identified tumor relapse-signature based on the expression of 64 miRNAs differentially expressed between relapse-free RCC patients and RCC patients who developed relapse (20 miRNAs were increased, 44 miRNAs were decreased). | 22492545 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | If further validated, we suggest that identified miRNAs might be used for identification of RCC patients at high risk of early relapse after nephrectomy in clinical practice. | 22492545 |
| Endometrial disorder | Epigenetic Alterations | Evidence suggests that a number of microRNA (miRNA) are aberrantly expressed in endometrial disorders with potential posttranscriptional regulation of their specific target genes, including ovarian steroid receptors. | 22492871 |
| Neuroblastoma | Epigenetic Alterations | In neuroblastoma caspase-8 is frequently silenced by DNA methylation. | 22493319 |
| Functional disorder, Carcinoma of lung | Epigenetic Alterations | Lysine specific demethylase 1 (LSD1) has been identified and biochemically characterized in epigenetics, but the pathological roles of its dysfunction in lung cancer remain to be elucidated. | 22493729 |
| Prostate Cancer Pathway | Epigenetic Alterations | Using whole genome expression profiling and whole genome methylation profiling, we have determined the genome-wide differences in genetic and epigenetic responses to genistein in prostate cancer cells before and after undergoing the EMT. | 22494660 |
| Barrett Esophagus | Epigenetic Alterations | microRNA-145 in Barretts oesophagus: regulating BMP4 signalling via GATA6. | 22504665 |
| sq. in | Epigenetic Alterations | Three unique miRNA expression profiles were found in tissue from EAC, BE and SQ, which showed that miRNA-145 was upregulated in BE compared with EAC and SQ. | 22504665 |
| Pancreatic carcinoma | Epigenetic Alterations | Differential signature of fecal microRNAs in patients with pancreatic cancer. | 22504911 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | These findings suggest that fecal microRNAs such as miR-181b and miR-210 may have potential to be used as new biomarkers for PCa screening. | 22504911 |
| Colorectal Cancer Pathway | Epigenetic Alterations | However, whether DNA methylation at the displacement loop (D-loop) region of mitochondrial DNA (mtDNA) has an effect on the expression of the rate-limiting enzyme, and, therefore, on oxidative phosphorylation in colorectal cancer remains to be determined. | 22505229 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | The role of epigenetic changes in determining the lung phenotype in IPF is unknown. | 22506007 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Our results provide evidence that epigenetic changes in IPF are widespread and potentially important. | 22506007 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methyltransferase 1, 3a, and 3b affect DNA methylation, and it is thought that they play an important role in the malignant transformation of various cancers. | 22520950 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | These data suggest that overexpression of various DNA methyltransferases might represent a critical event responsible for the epigenetic inactivation of multiple tumor suppressor genes, leading to the development of aggressive forms of sporadic breast cancer. | 22520950 |
| Paget Disease | Epigenetic Alterations | The presence of epigenetic and genetic lesions was then correlated to the patient pathology data to determine the potential role of these genes in extramammary Pagets disease etiology and progression. | 22522847 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Using paired tumor and non-tumor lung tissues from 146 individuals from three independent populations we sought to identify common changes in DNA methylation associated with the development of non-small cell lung cancer. | 22522909 |
| Carcinoma of lung | Epigenetic Alterations | Key epigenetic changes associated with lung cancer development: results from dense methylation array profiling. | 22522909 |
| Carcinoma of lung | Epigenetic Alterations | Epigenetic alterations are a common event in lung cancer and their identification can serve to inform on the carcinogenic process and provide clinically relevant biomarkers. | 22522909 |
| Breast Carcinoma | Epigenetic Alterations | One decade early onset of the breast cancer in Iranian females was reported but the basis of the observed difference has remained unclear and difference in gene silencing by epigenetic processes is suggested. | 22524805 |
| Diabetes Mellitus | Epigenetic Alterations | Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1. | 22525256 |
| Pelvic Organ Prolapse | Epigenetic Alterations | Increased microRNA-221/222 and decreased estrogen receptor a in the cervical portion of the uterosacral ligaments from women with pelvic organ prolapse. | 22527538 |
| Degenerative polyarthritis | Epigenetic Alterations | Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions. | 22527881 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells. | 22528944 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-10b (miR-10b) was recently reported to be dysregulated in some types of cancer and to play a role in invasion and metastasis. | 22528944 |
| Adenocarcinoma, Neuroendocrine Tumors | Epigenetic Alterations | Finally, we also present data supporting the hypothesis that there are differences in miRNA expression between adenocarcinomas and neuroendocrine tumors of the colon. | 22529906 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Differential expression of miRNAs in colorectal cancer: comparison of paired tumor tissue and adjacent normal mucosa using high-throughput sequencing. | 22529906 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | Some of these miRNAs are previously published as potential regulators in colorectal adenocarcinomas such as miR-1, miR-96 and miR-145. | 22529906 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Methylcap-seq reveals novel DNA methylation markers for the diagnosis and recurrence prediction of bladder cancer in a Chinese population. | 22529986 |
| Malignant Neoplasms, Aggressive behavior | Epigenetic Alterations | DNA methylation affects the aggressiveness of human malignancies. | 22532250 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Cancers with CpG island methylator phenotype (CIMP), a distinct group with extensive DNA methylation, show characteristic features in several types of tumors. | 22532250 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | CIMP classification using our six-marker panel has implications for personalized medical strategies for lung cancer patients; in particular, DNA methylation inhibitor might be of therapeutic benefit to patients with CIMP-positive tumors. | 22532250 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma. | 22532250 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | The NFATc1 P2 promoter and first intron was found to be hypomethylated and correlated with upregulation of both NFATc1 RNA and protein expression levels in CLL suggesting that an epigenetic mechanism is involved in the constitutive activation of NFAT activity in CLL cells. | 22534504 |
| Carcinoma, Intraepithelial Neoplasia | Epigenetic Alterations | A microRNA panel to discriminate carcinomas from high-grade intraepithelial neoplasms in colonoscopy biopsy tissue. | 22535378 |
| Colorectal Cancer Pathway | Epigenetic Alterations | This microRNA panel has considerable clinical value in the early diagnosis and optimal surgical decision-making of colorectal cancer. | 22535378 |
| Neoplasms | Epigenetic Alterations | The expression of 723 human microRNAs was measured in laser capture microdissected epithelial tumours from 133 snap-frozen surgical colorectal specimens. | 22535378 |
| Carcinoma, Adenoma | Epigenetic Alterations | One classifier of 14 microRNAs was identified with a prediction accuracy of 94.1% for discriminating carcinomas from adenomas. | 22535378 |
| Liver carcinoma | Epigenetic Alterations | VCP/p97, down-regulated by microRNA-129-5p, could regulate the progression of hepatocellular carcinoma. | 22536440 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations in the global DNA methylation status may be associated with an increased risk of some cancer types in humans. | 22536880 |
| Obesity | Epigenetic Alterations | miRNA and protein expression profiles of visceral adipose tissue reveal miR-141/YWHAG and miR-520e/RAB11A as two potential miRNA/protein target pairs associated with severe obesity. | 22537031 |
| Experimental Organism Basal Cell Carcinoma | Epigenetic Alterations | Expression of microRNAs in basal cell carcinoma. | 22540308 |
| Malignant Neoplasms | Epigenetic Alterations | Perturbations in the expression profiles of microRNAs (miRNAs) have been reported for a variety of different cancers. | 22540308 |
| Lymphoma | Epigenetic Alterations | Detection of these 3 miRNA in plasma of patients can contribute to the clinical diagnosis, treatment and prognosis evaluation of lymphoma. | 22541087 |
| Childhood Leukemia, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | [Abnormal expression of microRNA-124 in patients with leukemia or myelodysplastic syndrome and its significance]. | 22541098 |
| Primary malignant neoplasm | Epigenetic Alterations | Emerging evidence suggest that microRNAs could serve as non-invasive biomarker for cancer patients. | 22542158 |
| Pulmonary Hypertension | Epigenetic Alterations | Erythroid-specific transcriptional changes in PBMCs from pulmonary hypertension patients. | 22545094 |
| Clinical Coordinator, Colorectal Cancer Pathway, Cell Proliferation | Epigenetic Alterations | MicroRNA-143 (miRNA-143) is frequently down-regulated in colorectal cancer (CRC) and may influence CRC cell proliferation, apoptosis and sensitivity to 5-fluorouracil. | 22549179 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer. | 22549179 |
| Neoplasms | Epigenetic Alterations | Down-regulation of miRNA-143 was observed in 47 out of 77 (61%) tumours. | 22549179 |
| Clinical Coordinator | Epigenetic Alterations | Our data indicate that miRNA-143 expression levels serve as an independent prognostic biomarker for CRC in KRAS wild-type patients. | 22549179 |
| Clinical Coordinator | Epigenetic Alterations | Given its negative impact on CSS and PFS, miRNA-143 represents a novel prognosticator and a promising drug target for patients with CRC. | 22549179 |
| ovarian neoplasm, Primary malignant neoplasm | Epigenetic Alterations | Together, the results of this study suggest that low-dose decitabine altered DNA methylation of genes and cancer pathways, restoring sensitivity to carboplatin in patients with heavily pretreated ovarian cancer and resulting in a high RR and prolonged PFS. | 22549947 |
| ovarian neoplasm | Epigenetic Alterations | Epigenetic resensitization to platinum in ovarian cancer. | 22549947 |
| melanoma | Epigenetic Alterations | Histology-specific microRNA alterations in melanoma. | 22551973 |
| melanoma | Epigenetic Alterations | The lower expression level of six out of seven microRNAs in SSM compared with NM was confirmed by real-time PCR on a subset of cases in the training cohort and validated in an independent cohort of 97 melanoma cases (38 SSM, 59 NM). | 22551973 |
| Pancreatic carcinoma | Epigenetic Alterations | Target inhibition measured by quantification of histone acetylation was shown at doses of 10 mg/d and was maximal at 40 mg. A partial response was seen in one patient with metastatic acinar pancreatic carcinoma. | 22553374 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | DNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients. | 22555092 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Quantitative, methylation-specific (HeavyMethyl), real-time polymerase chain reaction assays were used to measure DNA methylation of PITX2 and SHOX2 in bisulfite-converted DNA from formalin-fixed, paraffin-embedded tissues from 474 non-small-cell lung cancer patients. | 22555092 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | DNA methylation of PITX2 and SHOX2 is an independent prognostic biomarker for disease progression in non-small-cell lung cancer patients. | 22555092 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. | 22560814 |
| Nasopharyngeal carcinoma, Primary malignant neoplasm, Nasopharyngitis | Epigenetic Alterations | We retrospectively analysed miRNA expression profiles in 312 paraffin-embedded specimens of nasopharyngeal carcinoma from Sun Yat-sen University Cancer Center (Guangzhou, China) and 18 specimens of non-cancer nasopharyngitis. | 22560814 |
| Tetranitromethane | Epigenetic Alterations | Identification of patients with the five-miRNA signature might add prognostic value to the TNM staging system and inform treatment decisions for patients at high risk of progression. | 22560814 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) can be used as prognostic biomarkers in many types of cancer. | 22560814 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | We aimed to identify miRNAs that were prognostic in patients with nasopharyngeal carcinoma. | 22560814 |
| Nasopharyngeal carcinoma, Nasopharyngitis | Epigenetic Alterations | 41 miRNAs were differentially expressed between nasopharyngeal carcinoma and non-cancer nasopharyngitis tissues. | 22560814 |
| Cataract | Epigenetic Alterations | In addition, several genes that were predicted to be targets of the identified miRNAs have been reported to be involved in lens development or cataract formation. | 22562507 |
| Cataract | Epigenetic Alterations | The differential expression of miRNAs suggests that these miRNAs have potential roles in lens development and/or cataract formation. | 22562507 |
| Carcinogenesis | Epigenetic Alterations | Correlation of epigenetic aberrance with STAT3 signaling pathway in gastric carcinogenesis. | 22562532 |
| Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) have been shown to be aberrantly expressed in many human carcinomas. | 22567743 |
| Endometriosis, Malignant neoplasm of endometrium | Epigenetic Alterations | A number of microRNAs (miRNAs), including miR-200 family, are aberrantly expressed in endometriosis and endometrial cancer. | 22569286 |
| FRAGILE X TREMOR/ATAXIA SYNDROME | Epigenetic Alterations | These results suggest that sequestration of specific rCGG repeat-binding proteins could lead to aberrant expression of selective miRNAs, which may modulate the pathogenesis of FXTAS by post-transcriptionally regulating the expression of specific mRNAs involved in FXTAS. | 22570635 |
| Carcinogenesis | Epigenetic Alterations | In carcinogenesis, methylation of DNA promoter regions results in inactivation of tumor-suppressing genes. | 22571342 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Epigenetic inactivation of PLCD1 in chronic myeloid leukemia. | 22576628 |
| Neoplasm Metastasis | Epigenetic Alterations | MicroRNAs (miRNAs), which are noncoding RNAs that regulate gene expression, are involved in tumor metastasis. | 22580051 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-93 inhibits tumor growth and early relapse of human colorectal cancer by affecting genes involved in the cell cycle. | 22581829 |
| Neoplasms | Epigenetic Alterations | MicroRNA-93 also suppressed tumor growth in null mice. | 22581829 |
| Clinical Coordinator | Epigenetic Alterations | This study showed that microRNA-93 can inhibit tumorigenesis and reduce the recurrence of CRC; these findings may have potential clinical applications for predicting the recurrence of CRC. | 22581829 |
| Clinical Coordinator | Epigenetic Alterations | Because deregulation of microRNAs is associated with CRC development and recurrence, the expression levels of microRNAs can be a simple and reliable biomarker to detect postoperative early relapse, thereby helping physicians to treat high-risk patients more efficiently. | 22581829 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNAs are frequently deregulated in cancer and have shown promise as tissue-based markers for cancer classification and prognostication. | 22583011 |
| HER2-positive carcinoma of breast | Epigenetic Alterations | Polymorphism rs4919510:C>G in mature sequence of human microRNA-608 contributes to the risk of HER2-positive breast cancer but not other subtypes. | 22586447 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We conducted a phase I/II trial of combined epigenetic therapy with azacitidine and entinostat, inhibitors of DNA methylation and histone deacetylation, respectively, in extensively pretreated patients with recurrent metastatic non-small cell lung cancer. | 22586682 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. | 22586682 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations are strongly associated with the development of cancer. | 22586682 |
| Liver damage, Hollings Cancer Center | Epigenetic Alterations | The above findings confirm the accumulation, in the progression of chronic liver damage to HCC, of a ROS-mediated oxidative DNA damage, and suggest that this correlates with induction of telomerase activity and, as a novel finding, with over-expression of miR-92, a microRNA that plays a role in both the apoptotic process and in cellular proliferation pathways. | 22587342 |
| Endophthalmitis | Epigenetic Alterations | Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling. | 22589448 |
| Inflammatory disorder | Epigenetic Alterations | Recent discovery of microRNAs and their negative gene regulation have provided new understanding in the pathogenesis of inflammatory diseases. | 22589448 |
| MIRLET7E gene | Epigenetic Alterations | Among these, four microRNAs (hsa-miR-1, hsa-let-7e, hsa-miR-9, and hsa-miR-182) were known to be associated with the inflammatory signaling pathway. | 22589448 |
| Neoplasms | Epigenetic Alterations | Gene mutation rates (EGFR, KRAS, STK11, TP53), chromosomal instability, regional copy number, and genomewide DNA methylation were significantly different among tumors of the molecular subtypes. | 22590557 |
| Primary malignant neoplasm | Epigenetic Alterations | While epigenetic and genetic modifications of DNA have been reported in blood of cancer patients, little is known about modifications of histones on circulating nucleosomes. | 22593510 |
| Laryngeal Squamous Cell Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are noncoding RNAs involved in posttranscriptional regulation of gene expression in cancer and provide new perspectives on the development of laryngeal squamous cell carcinoma (SCC). | 22605671 |
| Laryngeal Squamous Cell Carcinoma | Epigenetic Alterations | Comprehensive expression profiling of microRNAs in laryngeal squamous cell carcinoma. | 22605671 |
| Stomach Carcinoma | Epigenetic Alterations | Overexpression of IFITM1 has clinicopathologic effects on gastric cancer and is regulated by an epigenetic mechanism. | 22609115 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Although folate deficiency may contribute to DNA hypomethylation in colorectal cancer, findings on the association between total folate concentration and global DNA methylation have been inconsistent. | 22609762 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Blood and normal mucosa from 112 colorectal cancer patients and 114 healthy people were analyzed for global DNA methylation and folate species distribution using liquid chromatography tandem mass spectrometry. | 22609762 |
| Primary malignant neoplasm | Epigenetic Alterations | There was no evidence that mucosal global DNA methylation or folate distribution was related to the presence of cancer per se, suggesting that if abnormalities exist, they are confined to individual cells rather than the entire colon. | 22609762 |
| Malignant Neoplasms | Epigenetic Alterations | Epstein-Barr virus (EBV) is implicated in a range of B-cell malignancies and expresses unique microRNAs (EBV-miRNAs). | 22609801 |
| Aggressive behavior | Epigenetic Alterations | These data indicated that DNA methylation alterations at precancerous stages may determine tumor aggressiveness and patient outcome. | 22610075 |
| Hepatocarcinogenesis, Hepatitis C | Epigenetic Alterations | Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. | 22610915 |
| Inflammation | Epigenetic Alterations | Moreover, microRNA-155 (miR-155) plays an important role in regulating both inflammation and tumorigenesis. | 22610915 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. | 22613842 |
| Neoplasms | Epigenetic Alterations | We identified 766 genes showing altered DNA methylation between tumors and non-tumor lung. | 22613842 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Comparison of DNA methylation profiles between lung adenocarcinomas of current and never-smokers showed modest differences, identifying only LGALS4 as significantly hypermethylated and down-regulated in smokers. | 22613842 |
| Neoplasms | Epigenetic Alterations | Unsupervised analysis of the DNA methylation data identified two tumor subgroups, one of which showed increased DNA methylation and was significantly associated with KRAS mutation and to a lesser extent, with smoking. | 22613842 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Our analysis lays the groundwork for further molecular studies of lung adenocarcinoma by identifying novel epigenetically deregulated genes potentially involved in lung adenocarcinoma development/progression, and by describing an epigenetic subgroup of lung adenocarcinoma associated with characteristic molecular alterations. | 22613842 |
| Neoplasms | Epigenetic Alterations | Levels of candidate miRNAs were also quantified in MM tumor samples. | 22617246 |
| Adenocarcinoma, Squamous cell carcinoma of lung | Epigenetic Alterations | miRNAs expression profiling to distinguish lung squamous-cell carcinoma from adenocarcinoma subtypes. | 22618509 |
| Admitting diagnosis | Epigenetic Alterations | We identified differential expression profiles of miRNAs in AD and SCC. | 22618509 |
| Neoplasms | Epigenetic Alterations | A second-generation microRNA-based assay for diagnosing tumor tissue origin. | 22618571 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs are a family of noncoding, regulatory RNA genes involved in carcinogenesis. | 22618571 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs that are highly stable in clinical samples and tissue specific serve as ideal biomarkers for cancer diagnosis. | 22618571 |
| Neoplasms | Epigenetic Alterations | Our first-generation assay identified the tumor of origin based on 48 microRNAs measured on a quantitative real-time polymerase chain reaction platform and differentiated 25 tumor types. | 22618571 |
| Neoplasms | Epigenetic Alterations | A combination of a binary decision-tree and a k-nearest-neighbor classifier was developed to identify the tumor of origin based on the expression of 64 microRNAs. | 22618571 |
| Prostate Cancer Pathway | Epigenetic Alterations | Epigenetic markers of prostate cancer in plasma circulating DNA. | 22619380 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic differences are a common feature of many diseases, including cancer, and disease-associated changes have even been detected in bodily fluids. | 22619380 |
| Pancreatic carcinoma | Epigenetic Alterations | However, the mechanisms by which miRNAs regulate pancreatic cancer (PC) development remain poorly understood. | 22628193 |
| Neoplasms | Epigenetic Alterations | The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors. | 22638884 |
| Malignant Neoplasms | Epigenetic Alterations | On the base of optimizing experimental design and improving trial protocol, we wanted to know whether the circulating microRNA-21 was dysregulated in the common solid cancers. | 22638884 |
| MS gene | Epigenetic Alterations | It has also been reported that CD47 expression in multiple sclerosis is regulated by microRNAs. | 22641236 |
| Cardiovascular Diseases | Epigenetic Alterations | The data indicate a persisting epigenetic link between early-life maternal diet and/or foetal growth and cardiovascular disease risk in humans. | 22642564 |
| Primary malignant neoplasm | Epigenetic Alterations | The micro RNA (miRNA) mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase (MMP) inhibitor RECK. | 22642976 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | An evaluation of urinary microRNA reveals a high sensitivity for bladder cancer. | 22644299 |
| Carcinogenesis | Epigenetic Alterations | Changes in microRNA (miR) expression are seen in urothelial carcinogenesis in a phenotype-specific manner. | 22644299 |
| DICER1 protein, human | Epigenetic Alterations | MicroRNAs are posttranscriptional regulators of messenger RNA synthesis that are intracellularly processed and transferred by the microRNA-regulating machinery consisting of Drosha, Dicer, and Argonaute. | 22647351 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | By MassARRAY and pyrosequencing, we identified significant DNA methylation differences at the ID4 gene promoter and in the 5 region of members of the SFRP gene family in 62 AML patients compared with healthy controls. | 22647397 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Most work has focused on tissue and cell expression with few reports of circulating miRNAs in colorectal cancer. | 22648208 |
| Cardiovascular Diseases | Epigenetic Alterations | Micro-RNA-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease. | 22651868 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Micro-RNAs were detected by miR profiling in BMCs isolated from healthy volunteers (n = 6) or from patients with myocardial infarction (n = 6), and the results were confirmed by polymerase chain reaction (PCR) in a larger cohort (n = 37). | 22651868 |
| DICER1 protein, human | Epigenetic Alterations | Dicer and Drosha are two key enzymes that are involved in the processing of miRNA production. | 22658478 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs have been recently identified as important regulators that influence human carcinogenesis, cancer progression, and the interaction between the host and virus. | 22658643 |
| Bulbo-Spinal Atrophy, X-Linked | Epigenetic Alterations | Here we describe a novel therapeutic approach using the adeno-associated virus (AAV) vector-mediated delivery of a specific miRNA for SBMA. | 22660636 |
| Neurodegenerative Disorders | Epigenetic Alterations | Our results establish the proof of principle that disease-specific miRNA delivery could be useful in neurodegenerative diseases. | 22660636 |
| Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | Forty-one SNPs in 26 microRNA-related genes were genotyped in 1,097 patients with CRC recruited at the University of Texas MD Anderson Cancer Center (Houston, TX). | 22661538 |
| Clinical Coordinator | Epigenetic Alterations | Genetic polymorphisms in the microRNA pathway may predict prognosis in patients with stage III CRC treated with fluoropyrimidine-based chemotherapy. | 22661538 |
| Scleroderma | Epigenetic Alterations | microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma. | 22661558 |
| Sample Size Calculation | Epigenetic Alterations | Clarifying the role of miRNAs in SSc may result in a better understanding of this disease and the development of new therapeutic approaches. | 22661558 |
| Malignant Neoplasms | Epigenetic Alterations | A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. | 22662244 |
| Disorder of eye | Epigenetic Alterations | These results provide further evidence that patients with GO do not have a distinct genetic susceptibility to their eye disease and again suggest that environmental and/or epigenetic influences are at play. | 22663548 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Lower levels of genomic DNA methylation in blood DNA has been associated with risk of different cancers and several cancer risk factors. | 22665578 |
| Meningioma | Epigenetic Alterations | A microRNA expression signature predicts meningioma recurrence. | 22674195 |
| Meningioma | Epigenetic Alterations | Our results suggest that the use of miRNA profiling has significant potential as an effective diagnostic and prognostic marker in defining the expression signature of meningiomas and in predicting postsurgical outcomes. | 22674195 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | The aberrant expression of microRNAs (miRNAs) is associated with a variety of diseases, including cancer. | 22674195 |
| Meningioma | Epigenetic Alterations | After a two-phase selection and validation process, 14 miRNAs were found to exhibit significantly different expression profiles in meningioma samples compared to normal adjacent tissue (NAT) samples. | 22674195 |
| Stomach Carcinoma | Epigenetic Alterations | TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep). | 22675170 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Hence, blood-based microarray profiling of microRNA (miR) expression was performed in preoperative serum of 21 non-small cell lung cancer (NSCLC) patients and 11 healthy individuals by microfluid biochips containing 1158 different miRs. | 22675530 |
| Lung diseases, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Two out of the 30 most dysregulated miRs were further validated in serum of 97 NSCLC patients, 20 patients with benign lung diseases and 30 healthy individuals by TaqMan MicroRNA Assays. | 22675530 |
| Colorectal Carcinoma | Epigenetic Alterations | We analysed miRNA expression levels between MDR colorectal carcinoma cell line HCT116/L-OHP cells and their parent cell line HCT116 using a miRNA microarray. | 22676135 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression. | 22677169 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma. | 22681717 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | miR-182 is one of the most significantly up-regulated miRNAs in hepatocellular carcinoma (HCC). | 22681717 |
| Osteosarcoma | Epigenetic Alterations | Our findings indicate a crucial impact of deregulated miRNAs with consecutive changes in gene expression in osteosarcomas, which strongly suggests pathogenetic and potentially therapeutic implications. | 22682620 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Inhibitory effects of microRNA-34a on cell migration and invasion of invasive urothelial bladder carcinoma by targeting Notch1. | 22684561 |
| Malignant Neoplasms | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) play crucial roles in human cancers. | 22685290 |
| Chromosomal Loss | Epigenetic Alterations | Tumor-suppressor genes on chromosome X can be inactivated by a single hit, any of the point mutations, chromosomal loss and aberrant DNA methylation. | 22689052 |
| Malignant neoplasm of gastrointestinal tract | Epigenetic Alterations | These data showed that FHL1 is a methylation-silenced tumor-suppressor gene on chromosome X in gastrointestinal cancers, and that its silencing contributes to the formation of an epigenetic field for cancerization. | 22689052 |
| Neoplasms | Epigenetic Alterations | DNA methylation is one of the main epigenetic mechanisms and hypermethylation of CpG islands at tumor suppressor genes switches off these genes. | 22690089 |
| Hollings Cancer Center | Epigenetic Alterations | In conclusion, we identified 221 novel DNA methylation markers for HCC. | 22690089 |
| Schizophrenia | Epigenetic Alterations | DNA methylation in schizophrenia subjects: gender and MTHFR 677C/T genotype differences. | 22690662 |
| Verrucous carcinoma | Epigenetic Alterations | Differential expression of microRNAs miR-21, miR-31, miR-203, miR-125a-5p and miR-125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck. | 22690848 |
| Neoplasms | Epigenetic Alterations | Aberrant microRNA (miRNA) expression plays an important role in tumor formation and development. | 22692639 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | Integration of genetic and epigenetic changes in thyroid cancer will help identify relevant biologic pathways that drive its development. | 22694820 |
| Neoplasms | Epigenetic Alterations | The quantitative DNA methylation analysis of the candidate genes showed higher methylation proportion in the primary tumor tissue than that of the matched normal tissue and the differences were significant for the APC, BIN1, BMP6, BRCA1, CST6, ESR-b, P16, PTEN and TIMP3 promoter regions (P<0.05). | 22695536 |
| Malignant Neoplasms, Metastasis | Epigenetic Alterations | Invasion and metastasis are two important hallmarks of malignant tumors caused by complex genetic and epigenetic alterations. | 22695536 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Relationship between tumor DNA methylation status and patient characteristics in African-American and European-American women with breast cancer. | 22701537 |
| Breast Carcinoma | Epigenetic Alterations | Aberrant DNA methylation is critical for development and progression of breast cancer. | 22701537 |
| Each (qualifier value) | Epigenetic Alterations | Significant differences in the CDH13 methylation status were observed by comparing DNA methylation between AA and EA patients, with more obvious CDH13 methylation differences between the two patient groups in the ER- disease and among young patients (age<50). | 22701537 |
| Mammary Neoplasms | Epigenetic Alterations | In conclusion, the DNA methylation status of breast tumors was found to be significantly associated with clinicopathological features and race/ethnicity of the patients. | 22701537 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | MicroRNA expression signature in human abdominal aortic aneurysms. | 22704053 |
| Neoplasms | Epigenetic Alterations | The relationship between miRNA expression, patient survival and tumor pathological features was also examined. | 22704449 |
| Malignant neoplasm of urinary bladder, Metastasis, Neoplasms | Epigenetic Alterations | Expression of miRNAs involved in angiogenesis, tumor cell proliferation, tumor suppressor inhibition, epithelial-mesenchymal transition and activation of metastasis in bladder cancer. | 22704449 |
| Malignant neoplasm of urinary bladder, Metastasis, Neoplasms | Epigenetic Alterations | We analyzed the expression profile of a group of miRNAs involved in bladder cancer angiogenesis, tumor cell proliferation, tumor suppressor inhibition, epithelial-mesenchymal transition and metastasis activation. | 22704449 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Most miRNAs analyzed are down-regulated in bladder cancer. | 22704449 |
| melanoma | Epigenetic Alterations | Although several studies have shown a dysregulation of microRNA (miRNA) expression profiles in cutaneous melanoma, there has been little research on the miRNA machinery itself. | 22706980 |
| Cutaneous Melanoma | Epigenetic Alterations | The miRNA machinery in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi. | 22706980 |
| S100A4 protein, human | Epigenetic Alterations | The results of this study show that the miRNA machinery components argonaute-1, TARBP2 and SND1 are dysregulated in PCMM and CMMM compared to BMN and may play a role in the process of malignant transformation. | 22706980 |
| Prostate Cancer Pathway | Epigenetic Alterations | MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer. | 22710126 |
| palladium | Epigenetic Alterations | RNA was extracted from the PD effluent after PET, and intra-peritoneal expression of miRNA targets were quantified. | 22710867 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | A single nucleotide polymorphism in microRNA-146a is associated with the risk for nasopharyngeal carcinoma. | 22711332 |
| Malignant Neoplasms | Epigenetic Alterations | A common GC polymorphism within miRNA-146a precursor region (rs2910164) has been associated with the risk of various cancers despite the underlying mechanism is unclear. | 22711332 |
| Non-Malignant | Epigenetic Alterations | There is disagreement about the impact of this epigenetic event on protein expression of Cyclin A1 in malignant and non-malignant tissue and there hardly exists any information about possible relationships between Cyclin A1 expression and clinicopathological characteristics in HNSCC. | 22712549 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer. | 22716222 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA deregulation is a key feature of cancer; however, the molecular mechanisms underlying deregulation are unknown. | 22716222 |
| DICER1 protein, human | Epigenetic Alterations | Dicer is a central enzyme in microRNA processing essential for production of mature microRNAs which, in turn, regulate gene expression post-transcription. | 22716222 |
| Neoplasms | Epigenetic Alterations | We hypothesized that alterations in DNA methylation may play a role in the breakage of centromeric repeat sequences in these tumours. | 22718136 |
| Esophageal carcinoma, X-linked sideroblastic anemia | Epigenetic Alterations | To explore epigenetic changes in the gene encoding X chromosome-linked inhibitor of apoptosis-associated factor 1 (XAF1) during esophageal carcinogenesis. | 22719195 |
| Acute myocardial infarction | Epigenetic Alterations | Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction. | 22719221 |
| Septicemia | Epigenetic Alterations | Receiver operating characteristic curves were generated and the areas under the curve (AUC) for these six miRNAs for predicting sepsis mortality ranged from 0.610 (95%CI: 0.523-0.697) to 0.790 (95%CI: 0.719-0.861). | 22719975 |
| Septicemia | Epigenetic Alterations | Six serum miRNAs were identified as prognostic predictors for sepsis patients. | 22719975 |
| Alzheimers Disease | Epigenetic Alterations | Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease. | 22720070 |
| Squamous cell carcinoma of the head and neck, Neoplasms | Epigenetic Alterations | Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas. | 22722388 |
| Neoplasms | Epigenetic Alterations | The goal of this study was to describe the association between pretreatment diet and HNC tumor DNA methylation. | 22722388 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Tumor DNA methylation patterns were assessed using the Illumina Goldengate Methylation Cancer Panel. | 22722388 |
| MMP8 wt Allele, Neoplasms | Epigenetic Alterations | These preliminary results suggest that intake of folate, vitamin A and vitamin B12 may be associated with the tumor DNA methylation profile in HNC and enhance tumor suppression. | 22722388 |
| Primary malignant neoplasm, MMP8 wt Allele, Malignant Head and Neck Neoplasm | Epigenetic Alterations | Diet is associated with cancer prognosis, including head and neck cancer (HNC), and has been hypothesized to influence epigenetic state by determining the availability of functional groups involved in the modification of DNA and histone proteins. | 22722388 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-9 as potential biomarker for breast cancer local recurrence and tumor estrogen receptor status. | 22723919 |
| Alzheimers Disease | Epigenetic Alterations | Epigenetic regulation of BACE1 in Alzheimers disease patients and in transgenic mice. | 22728099 |
| cervical cancer, Human papilloma virus infection | Epigenetic Alterations | It has been reported that aberrant DNA methylation can be associated with HPV infection and cervical cancer, and folate is directly involved in DNA methylation via one-carbon metabolism. | 22729741 |
| Secondary malignant neoplasm of rectum | Epigenetic Alterations | MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. | 22735571 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | Liver metastasis tissues showed higher expression of miR-200c (primary CRC = 1.31 vs. liver metastasis = 1.59; p = 0.0014) and miR-141 (primary CRC = 0.14 vs. liver metastasis = 0.17; p = 0.0234) than did primary CRCs, which was significantly associated with hypomethylation of the promoter region of these miRNAs (primary CRC = 61.2% vs. liver metastasis = 46.7%; p < 0.0001). | 22735571 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Therefore, a genome-wide evaluation of DNA methylation loci in fibroblast-like synoviocytes (FLS) isolated from the site of disease in rheumatoid arthritis (RA) was performed. | 22736089 |
| Right arm | Epigenetic Alterations | RA and control FLS segregated based on DNA methylation, with 1859 differentially methylated loci. | 22736089 |
| Arthritis | Epigenetic Alterations | DNA methylation of critical genes suggests that RA FLS are imprinted and implicate epigenetic contributions to inflammatory arthritis. | 22736089 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation levels of vimentin, sFRP1 and HPP1 are significantly higher in colorectal cancer tissue. | 22736139 |
| Squamous cell carcinoma of oropharynx | Epigenetic Alterations | A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma. | 22736309 |
| Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7 | Epigenetic Alterations | This new miRNA signature was experimentally validated in an independent oropharyngeal SCC cohort. | 22736309 |
| Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7 | Epigenetic Alterations | A combined expression signature of these miRNAs was prognostic of oropharyngeal SCC, independent of common clinical features or HPV status. | 22736309 |
| Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7 | Epigenetic Alterations | Furthermore, 5 HPV-related miRNAs were identified, which may help to characterize HPV-induced cancers including both oropharyngeal and cervical SCC. | 22736309 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation of circulating DNA: a marker for monitoring efficacy of neoadjuvant chemotherapy in breast cancer patients. | 22744714 |
| Medullary carcinoma of thyroid | Epigenetic Alterations | MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary relationships with RET status and outcome. | 22747440 |
| Malignant Neoplasms, Medullary carcinoma of thyroid, Magnetic-Targeted Carriers | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in the pathogenesis of human cancers, including medullary thyroid carcinoma (MTC). | 22747440 |
| Magnetic-Targeted Carriers | Epigenetic Alterations | MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001). | 22747440 |
| Medullary carcinoma of thyroid, Magnetic-Targeted Carriers | Epigenetic Alterations | miRNAs are significantly dysregulated in MTC, and this dysregulation is probably an early event in C-cell carcinogenesis. | 22747440 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation. | 22749068 |
| Neoplasms, Leukemia, Myelocytic, Acute | Epigenetic Alterations | We examined 79 acute myeloid leukemia (AML) patients for DNA methylation of 12 tumor suppressor genes (TSG) and 24 homeobox domain (Hox) genes, and additionally for mutations in DNMT3A gene. | 22749068 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma. | 22752059 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The expression levels of the most upregulated miRNA, miR-375 were analyzed by quantitative real-time PCR in human ESCC specimens. | 22752059 |
| Neoplasms | Epigenetic Alterations | Our results indicate that HDACIs upregulate miRNAs, at least some of which act as tumor suppressors. | 22752059 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures. | 22753902 |
| Bipolar Disorder, "Alzheimers Disease | Epigenetic Alterations | Epigenetic modifications in frontal cortex from Alzheimers disease and bipolar disorder patients. | 22760556 |
| Admitting diagnosis | Epigenetic Alterations | AD and BD brains showed several epigenetic similarities, including global DNA hypermethylation, and histone H3 phosphorylation. | 22760556 |
| Admitting diagnosis | Epigenetic Alterations | These epigenetic modifications involving neuroinflammatory, AA cascade and synaptic markers may contribute to progression in AD and BD and identify new targets for drug development. | 22760556 |
| Squamous cell carcinoma, Neoplasms | Epigenetic Alterations | Here, we report that miRNA expression profiling provided more precise information when oral squamous cell carcinomas were subcategorized on the basis of clinicopathological parameters (tumor primary site, histological subtype, tumor stage, and HPV16 status). | 22761427 |
| Neoplasms | Epigenetic Alterations | Transfection of miR-7 and miR-21-mimics reduced the expression of RECK through direct miRNA-mediated regulation, and these miRNAs were inversely correlated with RECK in CAL 27 orthotopic xenograft tumors. | 22761427 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, the aberrant expressions of miRNAs have become a major focus in cancer research. | 22761427 |
| Neoplasms | Epigenetic Alterations | Further investigations demonstrated the regulation of the tumor suppressor gene reversion-inducing cysteine-rich protein with kazal motifs (RECK) by two keratinization-associated miRNAs, miR-7 and miR-21. | 22761427 |
| Malignant neoplasm of mouth, Aggressive behavior, Neoplasms | Epigenetic Alterations | Taken together, our data show that keratinization is associated with poor prognosis of oral cancer patients and keratinization-associated miRNAs mediate deregulation of RECK which may contribute to the aggressiveness of tumors. | 22761427 |
| Lynch Syndrome | Epigenetic Alterations | Recently, constitutional MLH1 epimutations have been identified in a subset of Lynch syndrome (LS) cases. | 22763379 |
| Early-onset, Neoplasms | Epigenetic Alterations | MLH1 methylation screening in lymphocyte DNA from patients with early-onset MLH1-methylated LS-associated tumors allows the identification of epimutation carriers. | 22763379 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic events are, along with genetic alteration, important in the development and progression of cancer. | 22765268 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Genetic and epigenetic alterations are the two key mechanisms in the development of hepatocellular carcinoma (HCC). | 22766745 |
| Hyperplasia, Chronic active hepatitis | Epigenetic Alterations | They might serve to increase the diagnostic reproducibility and improve discrimination, especially, between CAH and CA by miRNA expression profiles and between simple and complex hyperplasia through PTEN expression patterns. | 22766795 |
| Hyperplasia, Endometrial adenocarcinoma | Epigenetic Alterations | Expression of miRNAs and PTEN in endometrial specimens ranging from histologically normal to hyperplasia and endometrial adenocarcinoma. | 22766795 |
| Hyperplasia, Malignant neoplasm of endometrium | Epigenetic Alterations | We measured the expression of six miRNAs (miR-21, 182, 183, 200a, 200c and 205) in 75 formalin-fixed, paraffin-embedded normal, hyperplastic, and malignant endometrial tissue blocks using Taqman-based real-time PCR assays. | 22766795 |
| Endometrial Carcinoma, Hyperplasia, She Chinese, Chronic active hepatitis | Epigenetic Alterations | Expression of five miRNAs (miR-182, 183, 200a, 200c and 205) was significantly higher in endometrial carcinoma (CA) when compared with complex atypical hyperplasia (CAH), simple hyperplasia (SH) and normal endometrial tissue (P<0.05, respectively). | 22766795 |
| Endometrial Hyperplasia | Epigenetic Alterations | Considering the likelihood ratio and number of parameters, the composite panel of six miRNAs was the best marker, revealing a sensitivity of 91% and a specificity of 94% in differentiating endometrial CA from endometrial hyperplasia or normal endometrium while the individual miRNAs exhibited 64-77% sensitivity and 66-91% specificity. | 22766795 |
| Chronic active hepatitis | Epigenetic Alterations | Interestingly, in distinguishing endometrial CA from CAH, the composite panel of four miRNAs (miR-182, 183, 200a, 200c) was the best marker, producing 95% sensitivity and 91% specificity. | 22766795 |
| Endometrial Hyperplasia | Epigenetic Alterations | Aberrant expression of miRNAs and loss of PTEN expression are common in endometrial hyperplasia and CA. | 22766795 |
| Neoplasms, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Tumor suppressive microRNA-138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma. | 22766839 |
| Renal Cell Carcinoma Pathway, Primary malignant neoplasm, Refractory Cytopenia of Childhood | Epigenetic Alterations | Previously, our miRNA expression signature of renal cell carcinoma (RCC) revealed that microRNA-138 (miR-138) was significantly reduced in cancer cells. | 22766839 |
| Malignant Neoplasms | Epigenetic Alterations | Many studies have recently suggested that microRNAs (miRNAs) contribute to the development of various types of human cancers as well as to their invasive and metastatic capacities. | 22766839 |
| Primary malignant neoplasm | Epigenetic Alterations | Cancer cells exhibit two types of DNA methylation alterations: global DNA hypomethylation and site-specific CpG island promoter hypermethylation. | 22766991 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Selected gene promoter hypermethylation in normal esophageal mucosae has attracted attention as a surrogate marker for the epigenetic field defect induced by smoking and/or drinking in esophageal squamous cell carcinoma (ESCC). | 22766991 |
| Neoplasms | Epigenetic Alterations | The microRNA cluster C19MC is deregulated in parathyroid tumours. | 22767050 |
| Parathyroid Gland Adenocarcinoma | Epigenetic Alterations | A subset of over-expressed microRNAs (miRNAs) identified in parathyroid carcinomas (Ca) compared to normal glands belongs to C19MC, a cluster on chromosome 19q13.4 involved in stem cell biology and tumourigenesis. | 22767050 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | In the last decade, studies in hepatocellular carcinoma (HCC) demonstrate dysregulation of miRNAs expression. | 22767438 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation changes are common and relatively stable in various types of cancers, and may be used as diagnostic or prognostic biomarkers. | 22768131 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We performed DNA methylation profiling of samples from 48 patients with stage I NSCLC and 18 matching cancer-free lung samples using microarrays that cover the promoter regions of more than 14,500 genes. | 22768131 |
| Neoplasms | Epigenetic Alterations | Altered DNA methylation of tumor suppressor gene promoters plays a role in human carcinogenesis and DNA methyltransferases (DNMTs) are responsible for it. | 22768205 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs regulate gene expression at the post-transcriptional level and play important roles in cancer development, progression, and metastasis. | 22772712 |
| Malignant Neoplasms, Astrocytoma | Epigenetic Alterations | IDH1 mutations showed wide regulation of angiogenesis and genome-wide change of histone and DNA methylation, which were not suppressed as the malignancy level progressed, suggesting an early role of IDH1 mutations in astrocytoma tumorigenesis. | 22772731 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | Detection of methylated CEBPd genomic DNA may have utility as an epigenetic biomarker of primary breast carcinomas at increased risk of relapse and metastasis. | 22782348 |
| Glioma | Epigenetic Alterations | Alterations of DNA methylation play an important role in gliomas. | 22787434 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | The risk of colorectal cancer (CRC) may be influenced by aberrant DNA methylation and altered nucleotide synthesis and repair, possibly caused by impaired dietary folate intake as well as by polymorphic variants in one-carbon metabolism genes. | 22794911 |
| Neoplasms | Epigenetic Alterations | These findings suggest that the detection of microRNA-21 in serum might serve as a new tumor biomarker in diagnosis and assessment of prognosis of ESCCs. | 22799367 |
| Depressed mood | Epigenetic Alterations | We detected intensive DNA methylation within a recently described, functional important region of the ACE gene promoter including hypermethylation in depressed patients (p = 0.008) and a significant inverse correlation between the ACE serum concentration and ACE promoter methylation frequency in the total sample (p = 0.02). | 22808171 |
| Cardiovascular Diseases | Epigenetic Alterations | The results of the present study suggest that aberrations in ACE promoter DNA methylation may be an underlying cause of MD and probably a common pathogenic factor for the bi-directional relationship between MD and cardiovascular disorders. | 22808171 |
| Prostate Cancer Pathway | Epigenetic Alterations | Aberrant DNA methylation plays a role in prostate cancer progression. | 22810147 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Altered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance. | 22810507 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Circulating miRNA is a novel marker for head and neck squamous cell carcinoma. | 22811001 |
| Breast Carcinoma, Malignant Neoplasms, Carcinoma of lung, Prostate Cancer Pathway, Malignant neoplasm of urinary bladder, Colorectal Cancer Pathway | Epigenetic Alterations | Altered microRNAs (miRNAs) expression has been found in many cancers, including lung cancer, breast cancer, prostate cancer, bladder cancer and colorectal cancer. | 22811001 |
| Malignant Neoplasms | Epigenetic Alterations | Many recent studies have demonstrated that aberrant plasma miRNAs were also found in various types of cancers. | 22811001 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | We previously identified an miRNA signature for type 2 diabetes in the general population. | 22813605 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | In subjects with subsequent myocardial infarction, differential co-expression patterns of circulating miRNAs occur around endothelium-enriched miR-126, with platelets being a major contributor to this miRNA signature. | 22813605 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | One cluster included all miRNAs associated with the risk of future myocardial infarction. | 22813605 |
| Prostate carcinoma | Epigenetic Alterations | Identification of ZNF217, hnRNP-K, VEGF-A and IPO7 as targets for microRNAs that are downregulated in prostate carcinoma. | 22815235 |
| CHOANAL ATRESIA, POSTERIOR, Primary malignant neoplasm | Epigenetic Alterations | We previously detected several miRNAs, for example, miR-24 and miR-22, as significantly downregulated in PCa (Szczyrba et al., Mol Cancer Res 2010;8:529-38). | 22815235 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Additionally, for two genes that are deregulated in PCa (heterogeneous nuclear ribonucleoprotein K, hnRNP-K, and vascular endothelial growth factor A, VEGF-A), we identified two regulatory miRNAs, miR-205 and miR-29b. | 22815235 |
| Multiple Myeloma, Malignant neoplasm of testis | Epigenetic Alterations | Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity. | 22816680 |
| Malignant neoplasm of testis | Epigenetic Alterations | Epigenetic induction of an adaptive immune response to cancer testis antigens is safe and feasible in MM patients undergoing SCT. | 22816680 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer. | 22818121 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Five SNPs found in pre-miRNAs (rs11614913/miR-196a2, rs2910164/miR-146a, rs6505162/miR-423, rs2289030/miR-492, and rs895819/miR-27a) and 2 SNPs found in pri-miRNAs (rs7372209/miR-26a-1 and rs213210/miR-219-1) were genotyped in 388 patients with NSCLC. | 22818121 |
| Neoplasms | Epigenetic Alterations | Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in the development of LC. | 22818553 |
| Stomach Carcinoma | Epigenetic Alterations | These findings demonstrated that decreased RASAL1 expression is a characteristic of gastric cancer and regulated by epigenetic mechanisms. | 22825043 |
| Adenocarcinoma of duodenum | Epigenetic Alterations | The purpose was to identify possible subsets of duodenal adenocarcinomas based on microsatellite instability (MSI), DNA methylation, mutations in the KRAS and BRAF genes, clinicopathologic features, and prognosis. | 22825585 |
| Adenocarcinoma of duodenum | Epigenetic Alterations | Little information is available on genetic and epigenetic changes in duodenal adenocarcinomas. | 22825585 |
| Admitting diagnosis | Epigenetic Alterations | Furthermore, we found that SORL1 promoter DNA methylation might act as one of the mechanisms responsible for the differences in expression observed between blood and brain for both healthy elderly and AD patients groups. | 22836009 |
| Chronic Kidney Diseases | Epigenetic Alterations | We observed an alteration of the platelet messenger RNA (mRNA) and microRNA transcriptome in CKD patients. | 22836280 |
| Uremia | Epigenetic Alterations | Reduced in platelets of uraemic patients, phosphatidylcholine transfer protein (PCTP) and WD repeat-containing protein 1 (WDR1) were found to be regulated by microRNAs, the latter of which involving hsa-miR-19b, a microRNA increased in platelets of uraemic patients and involved in platelet reactivity. | 22836280 |
| Uremia, Chronic Kidney Diseases | Epigenetic Alterations | These results suggest that an alteration of microRNA-based mRNA regulatory mechanisms may underlie the platelet response to uremia and entail the development of platelet-related complications in CKD. | 22836280 |
| Mesothelioma | Epigenetic Alterations | Our goal is to identify DNA methylation of these three candidate genes in two peritoneal mesothelioma cases. | 22836805 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | Recent research on the pathogenesis of malignant pleural mesothelioma has indicated that both epigenetic and genetic alterations contribute to tumorigenesis. | 22836805 |
| Mesothelioma | Epigenetic Alterations | Here, we hypothesize that peritoneal mesothelioma also has an epigenetic alteration in the same genes (Kazal-type serine peptidase inhibitor domain 1 (KAZALD1), transmembrane protein 30B (TMEM30B), and mitogen-activated protein kinase 13 (MAPK13)). | 22836805 |
| Neoplasms | Epigenetic Alterations | The role of microRNAs (miRNAs) in tumor biology might pinpoint an alteration in expression of miRNAs as new diagnostic/prognostic biomarkers. | 22836856 |
| SERPINB3 wt Allele | Epigenetic Alterations | These results suggest that regulation of podoplanin is not simple, but in the majority of OSCC cell lines, its expression is positively and negatively regulated by TGF-b receptor/Smad signaling pathway and epigenetic mechanism leading to squamous differentiation, respectively. | 22840788 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Expression of miRNA-146a in nasopharyngeal carcinoma is upregulated by Epstein-Barr virus latent membrane protein 1. | 22843060 |
| Nasopharyngitis | Epigenetic Alterations | The miRNA-146a levels in NPC were significantly higher than that in chronic nasopharyngitis (p<0.01), and were higher in CNE1-GL cells than those in CNE1 cells (p<0.01). | 22843060 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Overexpression of Epstein-Barr virus-encoded microRNA-BART7 in undifferentiated nasopharyngeal carcinoma. | 22843893 |
| Septicemia | Epigenetic Alterations | Corticosteroid resistance in sepsis is influenced by microRNA-124--induced downregulation of glucocorticoid receptor-a. | 22846781 |
| TSC22D3 gene | Epigenetic Alterations | Furthermore, a glucocorticoid-induced three-fold upregulation of microRNA-124 was found. | 22846781 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Genetic variants in miRNAs predict bladder cancer risk and recurrence. | 22846912 |
| Carcinogenesis | Epigenetic Alterations | miRNAs play important roles in numerous cellular processes, including development, proliferation, apoptosis, and carcinogenesis. | 22846912 |
| Secondary malignant neoplasm of female breast | Epigenetic Alterations | MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis. | 22847191 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | Recent studies have suggested that microRNA-10b (miR-10b) acts as a promoter of metastasis in breast cancer, although the underlying mechanism remains largely unknown. | 22847191 |
| Neoplasms, Neoplasm Metastasis | Epigenetic Alterations | The tumor suppressor gene p53 has been implicated in the regulation of epithelial-mesenchymal transition (EMT) and tumor metastasis by regulating microRNA (miRNA) expression. | 22847613 |
| Hepatitis B, Liver carcinoma | Epigenetic Alterations | Association of polymorphism in pri-microRNAs-371-372-373 with the occurrence of hepatocellular carcinoma in hepatitis B virus infected patients. | 22848681 |
| Inflammatory disorder, MS gene | Epigenetic Alterations | Since miR-155 has recently been demonstrated to up-regulate IFN-g, this microRNA might represent a novel therapeutic target in HAM/TSP, as recently demonstrated in multiple sclerosis, another neuroinflammatory disease. | 22848768 |
| Pancreatic carcinoma | Epigenetic Alterations | Expression of microRNAs in patients with pancreatic cancer and its prognostic significance. | 22850622 |
| Adenocarcinoma of pancreas | Epigenetic Alterations | Investigation of expression profile of well-established microRNAs in pancreatic adenocarcinoma, and its correlation with clinicopathological factors. | 22850622 |
| Prostate Cancer Pathway, Inflammation | Epigenetic Alterations | Genetic factors regulating inflammation and DNA methylation associated with prostate cancer. | 22850906 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The GNMT T allele may influence PCa risk by affecting DNA methylation and prostate gene expression. | 22850906 |
| Stomach Carcinoma | Epigenetic Alterations | [Expression of microRNA-183 in stage II ( gastric cancer and its association with Ezrin protein]. | 22851079 |
| Pancreatic carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Prognostic microRNAs in cancer tissue from patients operated for pancreatic cancer--five microRNAs in a prognostic index. | 22851141 |
| Primary malignant neoplasm | Epigenetic Alterations | MiRNAs were purified from formalin-fixed paraffin embedded (FFPE) cancer tissue from 225 patients operated for PC. | 22851141 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer. | 22854542 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | This study seeks to identify novel miRNA-regulated molecular pathways in prostate cancer (PCa). | 22854542 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The miRNA expression signature in clinical specimens of PCa showed that 56 miRNAs were significantly downregulated in PCa compared with non-PCa tissues. | 22854542 |
| Metastasis, Neoplasms | Epigenetic Alterations | microRNAs (miRNAs) have key roles in human tumorigenesis, tumor progression and metastasis. | 22854542 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | miRNAs are aberrantly expressed in many human cancers and can function as tumor suppressors or oncogenes that target many cancer-related genes. | 22854542 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Identification and categorization of the molecular pathways regulated by tumor suppressive miRNAs could provide new information about the molecular mechanisms of PCa tumorigenesis. | 22854542 |
| Papillary thyroid carcinoma, F9 gene | Epigenetic Alterations | Correlation between clinicopathogenetic features and the expression of specific miRNAs is unclear in papillary thyroid carcinoma (PTC). | 22855362 |
| Stomach Carcinoma | Epigenetic Alterations | Plasma microRNAs, miR-223, miR-21 and miR-218, as novel potential biomarkers for gastric cancer detection. | 22860003 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Plasma microRNA profiles for bladder cancer detection. | 22863868 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Plasma miRNA was isolated from 20 patients with bladder cancer and 18 noncancerous controls. | 22863868 |
| Prostate carcinoma | Epigenetic Alterations | Do microRNA 96, 145 and 221 expressions really aid in the prognosis of prostate carcinoma? | 22864280 |
| Clinical Coordinator | Epigenetic Alterations | Genetic and epigenetic alterations of APC may therefore be associated with dietary and lifestyle risk factors for CRC. | 22864938 |
| Helicobacter pylori | Epigenetic Alterations | Helicobacter pylori decreases p27 expression through the delta opioid receptor-mediated inhibition of histone acetylation within the p27 promoter. | 22867947 |
| Clinical Coordinator | Epigenetic Alterations | MiRNAs are non-protein-coding RNAs regulating gene expression that play a role in CRC development. | 22868372 |
| Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | Levels of 380 miRNAs were determined using microfluidic array technology (Applied Biosystems) in a "training" set of 30 CRC patients from whom cancer and adjacent normal tissue were collected. | 22868372 |
| Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | The 4 most dysregulated miRNAs (P < 0.05, false discovery rate (FDR): 10%) were then validated in a second blinded "test" set of 16 CRC patients from whom cancer and normal adjacent tissue had been collected. | 22868372 |
| Clinical Coordinator | Epigenetic Alterations | Validated tissue miRNAs were then evaluated in a plasma "test" set consisting of 30 CRC patients and 30 individuals without CRC. | 22868372 |
| Clinical Coordinator | Epigenetic Alterations | The most dysregulated tissue miRNAs were then validated in an independent new plasma test set consisting of 20 CRC patients with 20 age-, -, and race-matched subjects without CRC. | 22868372 |
| Clinical Coordinator | Epigenetic Alterations | The 2 most upregulated (miR-31; miR-135b) and most downregulated (miR-1; miR-133a) miRNAs identified CRC in our "test" set with 100% sensitivity and 80% specificity. | 22868372 |
| Clinical Coordinator | Epigenetic Alterations | Plasma miRNAs provide reliable and noninvasive markers for CRC. | 22868372 |
| Disease | Epigenetic Alterations | Serum microRNAs may be useful biomarkers for diagnosing human diseases. | 22868808 |
| Neoplasms | Epigenetic Alterations | An expanded patient cohort (tumor n=149, matched normal n=30) also showed significant MIR-205 DNA methylation in tumors compared with normal, and MIR-205 hypermethylation is significantly associated with biochemical recurrence (hazard ratio=2.005, 95% confidence interval (1.109, 3.625), P=0.02), in patients with low preoperative prostate specific antigen. | 22869146 |
| Prostate Cancer Pathway | Epigenetic Alterations | Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer. | 22869146 |
| Carcinogenesis | Epigenetic Alterations | Deregulation of microRNA (miRNA) expression can have a critical role in carcinogenesis. | 22869146 |
| Prostate Cancer Pathway | Epigenetic Alterations | Here we show in prostate cancer that miRNA-205 (miR-205) transcription is commonly repressed and the MIR-205 locus is hypermethylated. | 22869146 |
| Glioblastoma Multiforme | Epigenetic Alterations | A novel volume-age-KPS (VAK) glioblastoma classification identifies a prognostic cognate microRNA-gene signature. | 22870228 |
| SCGB3A1 wt Allele | Epigenetic Alterations | Methylation of HIN-1 promoter is a novel epigenetic biomarker associated with poor outcomes in OCCA patients. | 22871047 |
| Malignant Neoplasms, Carcinogenesis, CHOANAL ATRESIA, POSTERIOR, Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation plays an important role in carcinogenesis and is being recognized as a promising diagnostic and prognostic biomarker for a variety of malignancies including Prostate cancer (PCa). | 22874102 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Subsequently, we have quantified KLK6 and KLK10 DNA methylation levels in two independent cohorts of PCa patients operated by radical prostatectomy between 2007-2011 (Cohort I, n = 150) and 1998-2001 (Cohort II, n = 124). | 22874102 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The results suggest that KLK6 and KLK10 DNA methylation distinguishes organ confined from locally invasive PCa and may have prognostic value. | 22874102 |
| Inflammatory disorder, Periodontitis | Epigenetic Alterations | The role of epigenetic regulation in inflammatory diseases such as periodontitis is poorly known. | 22875665 |
| Malignant tumor of colon, Colorectal Cancer Pathway | Epigenetic Alterations | Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry. | 22878509 |
| Adenocarcinoma of ampulla of Vater, Adenocarcinoma of pancreas | Epigenetic Alterations | MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma. | 22878649 |
| Adenocarcinoma of ampulla of Vater, Adenocarcinoma of pancreas | Epigenetic Alterations | The expression of 664 microRNAs in tissue from 170 pancreatic adenocarcinomas and 107 ampullary adenocarcinomas were analyzed using a commercial microRNA assay. | 22878649 |
| Adenocarcinoma of ampulla of Vater | Epigenetic Alterations | MicroRNA profiles of pancreatic and ampullary adenocarcinomas were correlated (0.990). | 22878649 |
| Pancreatic carcinoma, Adenocarcinoma of pancreas | Epigenetic Alterations | MicroRNA expression profiles for pancreatic cancer described in the literature were consistent with our findings, and the microRNA profile for pancreatic adenocarcinoma (miR-196b-miR-217) was validated. | 22878649 |
| Adenocarcinoma of ampulla of Vater | Epigenetic Alterations | We also identified microRNA profiles to subclassify ampullary adenocarcinomas into pancreatobiliary or intestinal type. | 22878649 |
| Pancreatitis, Chronic, Adenocarcinoma of ampulla of Vater | Epigenetic Alterations | A diagnostic 19 microRNA classifier was constructed which without micro-dissection could discriminate pancreatic and ampullary adenocarcinomas from chronic pancreatitis and normal pancreas with high sensitivity and accuracy. | 22878649 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs have potential as diagnostic cancer biomarkers. | 22878649 |
| Pancreatic carcinoma | Epigenetic Alterations | In all, 43 microRNAs had higher and 41 microRNAs reduced expression in pancreatic cancer compared with normal pancreas. | 22878649 |
| Pancreatitis, Chronic, Adenocarcinoma of pancreas | Epigenetic Alterations | In all, 32 microRNAs were differently expressed in pancreatic adenocarcinoma compared with chronic pancreatitis (17 higher; 15 reduced). | 22878649 |
| Fibrosis Assessment, Aortic Valve Stenosis | Epigenetic Alterations | Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients. | 22882958 |
| Degenerative polyarthritis | Epigenetic Alterations | Amongst these 7 human miRNAs, 1 was up-regulated in OA chondrocytes (hsa-miR-483-5p) and 6 were up-regulated in normal chondrocytes (hsa-miR-149*, hsa-miR-582-3p, hsa-miR-1227, hsa-miR-634, hsa-miR-576-5p and hsa-miR-641). | 22883423 |
| Degenerative polyarthritis | Epigenetic Alterations | We have identified 7 miRNAs differentially expressed in OA and normal chondrocytes. | 22883423 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC. | 22884253 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Quantitative real-time PCR was used to measure mRNA expression and DNA methylation of GST-PI in paired tumor (T) and non-tumor (N) lung tissue of 91 NSCLC patients. | 22884253 |
| Tetranitromethane, Neoplasms | Epigenetic Alterations | The median GST-PI methylation was not significantly different between T and N. No associations were seen between the mRNA expression or DNA methylation levels and clinical or histopathologic parameters such as gender, age, TNM stage, tumor histology and grading. | 22884253 |
| Aggressive behavior, Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | High levels of GST-PI DNA methylation in tumor tissue of NSCLC patients have a potential as a biomarker identifying subpopulations with a more aggressive tumor biology. | 22884253 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer. | 22885837 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Recently, microRNA-124 (miR-124) has been demonstrated as a potential tumor suppressor in several types of cancers. | 22885837 |
| Neoplasms | Epigenetic Alterations | The results showed that miRNA expression (increased or decreased) in the paired benign and tumor tissue was consistent between the two methods in all cases. | 22886225 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNA profile in rectal cancer showed unique characteristics, and identified a series of new, aberrantly expressed miRNAs. | 22886225 |
| Primary malignant neoplasm | Epigenetic Alterations | [Identification of aberrantly expressed miRNAs in rectal cancer]. | 22886225 |
| Primary malignant neoplasm | Epigenetic Alterations | To identify aberrantly expressed miRNAs in rectal cancer. | 22886225 |
| Malignant Neoplasms, Colorectal Cancer Pathway | Epigenetic Alterations | All 6 paired rectal cancers were classified pathology stage C or D. Eighty-eight miRNAs were up-regulated and 46 miRNAs have been reported in colorectal cancer; 40 miRNAs were down-regulated in rectal cancers and 15 miRNAs have been reported in colorectal cancer. | 22886225 |
| Prostate Cancer Pathway, Hormone refractory prostate cancer | Epigenetic Alterations | We demonstrated that serum samples from patients of low risk, localized prostate cancer and metastatic CRPC patients exhibit distinct circulating miRNA signatures. | 22887127 |
| Prostate Cancer Pathway | Epigenetic Alterations | Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer. | 22887127 |
| Prostate Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | In the search for improved minimally invasive methods to follow cancer pathogenesis, the correlation of disease status with the expression patterns of circulating miRNAs may indicate the potential importance of circulating miRNAs as prognostic markers for prostate cancer progression. | 22887127 |
| Atypical Reparative Cell, CRYAA gene | Epigenetic Alterations | To assess the potential contribution of epigenetic regulation of CRYAA genes relevant to ARC pathogenesis, we evaluated DNA methylation, a tissue-specific genetic modulation that affects gene expression. | 22889833 |
| CRYAA gene, Cataract | Epigenetic Alterations | The evidence presented suggests that CRYAA undergoes epigenetic repression in the lens epithelia in age-related nuclear cataract. | 22889833 |
| Cardiac Arrest | Epigenetic Alterations | Circulating microRNAs after cardiac arrest. | 22890253 |
| Acute Coronary Syndrome, Cardiac Arrest | Epigenetic Alterations | While the potential of circulating microRNAs as biomarkers of acute coronary syndromes is an active field of investigation, it is unknown whether microRNAs are associated with outcome in cardiac arrest patients. | 22890253 |
| Brain Injuries, Cardiac Arrest | Epigenetic Alterations | In vitro experiments showed that both miR-122 and miR-21 are produced by neuronal cells, indicating that the elevation of circulating levels of these microRNAs after cardiac arrest may reflect brain damage. | 22890253 |
| Cardiac Arrest | Epigenetic Alterations | As compared to neuron-specific enolase, circulating microRNAs are modest but significant predictors of neurological outcome and mortality in this small group of patients with cardiac arrest. | 22890253 |
| melanoma, Neoplasms | Epigenetic Alterations | In situ measurement of miR-205 in malignant melanoma tissue supports its role as a tumor suppressor microRNA. | 22890556 |
| Neoplasms | Epigenetic Alterations | We utilized quantitative in situ hybridization (qISH) to evaluate the tumor suppressing properties of miRNA, miR-205 in a population of human tumors. | 22890556 |
| melanoma, Neoplasms | Epigenetic Alterations | Low levels of melanoma cell miR-205 expression as quantified by ISH show worse outcome, supporting the role of miR-205 as a tumor suppressor miRNA. | 22890556 |
| melanoma, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Oncogenic and tumor suppressing microRNAs (miRNAs) have emerged as key regulators of gene expression in many types of cancer including melanoma. | 22890556 |
| Glioblastoma Multiforme | Epigenetic Alterations | Plasma MicroRNA-21 concentration may be a useful biomarker in glioblastoma patients. | 22891879 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-21 was shown to induce glioblastoma growth. | 22891879 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05). | 22891879 |
| Glioblastoma Multiforme | Epigenetic Alterations | Circulating microRNA-21 might be a useful biomarker in glioblastoma. | 22891879 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs are proposed as plasma biomarkers in cancer. | 22891879 |
| Neoplasms | Epigenetic Alterations | However, Pearson analysis showed no statistical correlation in the relative miRNAs expression between plasma and esophageal tissues, which suggested different origins of circulating miRNAs distinct from tumor cell miRNAs. | 22891887 |
| Progranulins, Frontotemporal dementia | Epigenetic Alterations | TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways. | 22895706 |
| Progranulins, Depression, CTCAE, TMEM106B gene, Frontotemporal dementia | Epigenetic Alterations | Thus, TMEM106B is an FTLD-TDP risk gene, with microRNA-132/212 depression as an event which can lead to aberrant overexpression of TMEM106B, which in turn alters progranulin pathways. | 22895706 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Real-time polymerase chain reaction was used to profile microRNA (miRNA) in tumor tissue from 50 breast cancer patients using non-tumor breast tissue from each patient as a control. | 22898264 |
| Breast Carcinoma | Epigenetic Alterations | We have focussed on three miRNA; miR-21, miR-125b and miR-191, all of which have been implicated in breast cancer with either proven or predicted target genes involved in critical cancer-associated cellular pathways. | 22898264 |
| Breast Carcinoma | Epigenetic Alterations | These observations, although a proof of principle finding at this time, show that a combined expression profile of two miRNA (miR-125b/miR-191 and miR-21/miR-191) can discriminate between breast cancer and non-tumor tissue with high specificity and sensitivity. | 22898264 |
| Inflammatory Bowel Diseases | Epigenetic Alterations | MicroRNA expression patterns in indeterminate inflammatory bowel disease. | 22899284 |
| Ulcerative Colitis, Colitis, Crohn Disease-like Reaction | Epigenetic Alterations | Among the 16 indeterminate colitis patients, 15 showed ulcerative colitis-like and one Crohns disease-like microRNA pattern. | 22899284 |
| Ulcerative Colitis, Crohn Disease, Colitis | Epigenetic Alterations | MicroRNA expression patterns in indeterminate colitis are far more similar to those of ulcerative colitis than Crohns disease. | 22899284 |
| Colitis, Ulcer | Epigenetic Alterations | MicroRNA expression patterns of indeterminate colitis provide molecular evidence indicating that most cases are probably ulcerative colitis-similar to the data from long-term clinical follow-up studies. | 22899284 |
| Inflammatory Bowel Diseases | Epigenetic Alterations | Validation of microRNA results by additional long-term outcome data is needed, but the data presented show promise for improved classification of indeterminate inflammatory bowel disease. | 22899284 |
| Ulcerative Colitis, Crohn Disease, Colitis | Epigenetic Alterations | The average expression level of all five microRNAs was statistically different between indeterminate colitis and Crohns disease groups (P<0.05); no significant difference was present between indeterminate and ulcerative colitis groups. | 22899284 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-126 inhibits tumor cell growth and its expression level correlates with poor survival in non-small cell lung cancer patients. | 22900072 |
| Neoplasms | Epigenetic Alterations | It is controversial whether microRNA-126 is a tumor suppressive or oncogenic miRNA. | 22900072 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | More experiments are needed to determine whether microRNA-126 is associated with non-small cell lung cancer risk and prognosis. | 22900072 |
| Neoplasms | Epigenetic Alterations | We analyzed the associations of the microRNA-126 expression between genetic variants within microRNA-126 and clinical information including smoking status, sex, age, and histological type and the tumor stage. | 22900072 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Over-expression of microRNA-126 in NSCLC cell lines decreased cell proliferation in vitro and tumor growth in the nude mouse xenograft model. | 22900072 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | The expression level of microRNA-126 was decreased in NSCLC lines and tumor tissues. | 22900072 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our data indicate that microRNA-126 is a tumor-suppressor gene in NSCLC and low microRNA-126 expression is a unfavorable prognostic factor in NSCLC patients. | 22900072 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Therefore, further research is needed to explore the tumor suppressive functions of microRNA-126 in NSCLC. | 22900072 |
| Tuberculosis, Pulmonary | Epigenetic Alterations | Altered microRNA signatures in sputum of patients with active pulmonary tuberculosis. | 22900099 |
| Tuberculosis | Epigenetic Alterations | We found that 95 miRNAs were differentially expressed between tuberculosis group and controls. | 22900099 |
| Tuberculosis | Epigenetic Alterations | More miRNAs (52 out of 95 miRNAs) were underexpressed than overexpressed during tuberculosis infection. | 22900099 |
| Tuberculosis, Pulmonary | Epigenetic Alterations | For the first time, differential expression of miRNAs in sputum was found in active pulmonary tuberculosis. | 22900099 |
| Neoplasms, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Taken together, miR-370 may function as a tumor suppressor by targeting FoxM1, and the epigenetic silence of miR-370 thus leads to derepression of FoxM1 expression and consequently contributes to AML development and progression. | 22900969 |
| Malignant Neoplasms, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Recent evidence has accumulated that MicroRNA (miRNA) dysregulation occurs in the majority of human malignancies including acute myeloid leukemia (AML) and may contribute to onco-/leukemo-genesis. | 22900969 |
| Neoplasms, Leukemia, Myelocytic, Acute | Epigenetic Alterations | The tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemia. | 22900969 |
| Metastasis, Neoplasms | Epigenetic Alterations | The discovery that microRNA (miRNA) regulates metastasis provide a principal molecular basis for tumor heterogeneity. | 22901144 |
| Secondary malignant neoplasm of female breast, Neoplasms | Epigenetic Alterations | It is necessary to discover the mechanism of breast cancer metastasis in relation to the fact that there is a differential distribution of crucial microRNA in tumors from centers to edges. | 22901144 |
| Breast Carcinoma | Epigenetic Alterations | Our data suggest that miR-20a and miR-20b are differentially distributed in breast cancer, while VEGF-A and HIF-1alpha mRNA had coincident distributions, and VEGF-A and HIF-1alpha proteins had uneven and opposing distributions to the miRNAs. | 22901144 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genome-wide analysis of aberrant DNA methylation for identification of potential biomarkers in colorectal cancer patients. | 22901147 |
| Malignant Neoplasms, Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic modifications, such DNA methylation, have also been implicated in many cancers but have yet to be examined in the East Asian population of colorectal cancer patients. | 22901147 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer. | 22903020 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We are interested in revealing the relationship between deregulated miRNAs and deoxycholic acid in colorectal cancer development. | 22903020 |
| Amyotrophic Lateral Sclerosis | Epigenetic Alterations | A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis. | 22903028 |
| Neurodegenerative Disorders | Epigenetic Alterations | In addition, misregulation of microRNAs contributes to some mental disorders and neurodegeneration diseases. | 22903028 |
| Disease | Epigenetic Alterations | MicroRNAs, a class of noncoding RNAs, play roles in human diseases. | 22903258 |
| Rheumatoid Arthritis | Epigenetic Alterations | Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation. | 22903258 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | The different expression of miRNAs could modulate the expression of angiogenic and antiangiogenic factors, which may play an important role in the pathogenesis of endometrial cancer. | 22904162 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNA) are involved in tumor development and are commonly dysregulated in PCA. | 22905187 |
| Pancreatic carcinoma | Epigenetic Alterations | Feasibility of fecal microRNAs as novel biomarkers for pancreatic cancer. | 22905187 |
| Pancreatitis | Epigenetic Alterations | The expression of the remaining three miRNAs (miR-21, -210 and -375) remained unchanged among controls and the patients with either chronic pancreatitis or PCA. | 22905187 |
| Breast Carcinoma Metastatic in the Bone | Epigenetic Alterations | Serum overexpression of microRNA-10b in patients with bone metastatic primary breast cancer. | 22906258 |
| Hypospadias | Epigenetic Alterations | Genome-wide DNA methylation profiling of CpG islands in hypospadias. | 22906644 |
| Hypospadias | Epigenetic Alterations | Our findings suggest DNA methylation patterns are useful in identifying new genes such as SCARB1 and MYBPH that may be involved in the etiology of hypospadias. | 22906644 |
| Colorectal Carcinoma | Epigenetic Alterations | The topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers. | 22911899 |
| Carcinoma of lung | Epigenetic Alterations | Dysfunctions associated with methylation, microRNA expression and gene expression in lung cancer. | 22912875 |
| Carcinoma of lung | Epigenetic Alterations | By comparing the MCC ranks of methylation, microRNA and mRNA for each GO term, we classified the GO sets into six groups and identified the dysfunctional methylation, microRNA and mRNA gene sets in lung cancer. | 22912875 |
| Prostate Cancer Pathway | Epigenetic Alterations | Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer. | 22915211 |
| Prostate Cancer Pathway | Epigenetic Alterations | SFRP2 methylation in combination with other epigenetic markers may be a useful biomarker of prostate cancer. | 22915211 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Epigenetic aberrations have been reported in hepatocellular carcinoma (HCC). | 22915658 |
| Neoplasms | Epigenetic Alterations | Epigenetic therapy with belinostat demonstrates tumor stabilization and is generally well-tolerated. | 22915658 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | 450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments. | 22922567 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Intriguingly, CLL prognostic genes (for example, CLLU1, LPL, ZAP70 and NOTCH1), epigenetic regulator (for example, HDAC9, HDAC4 and DNMT3B), B-cell signaling (for example, IBTK) and numerous TGF-b and NF-kB/TNF pathway genes were alternatively methylated between subgroups. | 22922567 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | DNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer. | 22923190 |
| Carcinoma of lung | Epigenetic Alterations | We found that lung cancer cells or tissues had significantly different DNA methylation and mRNA levels than normal human bronchial epithelial cells or adjacent non-tumorous tissues, respectively. | 22923190 |
| Carcinoma of lung | Epigenetic Alterations | High DNA methylation of ILs promoters in lung cancer cells or tissues was associated with low mRNA levels. | 22923190 |
| Primary malignant neoplasm | Epigenetic Alterations | We found an inverse correlation between DNA methylation of IL1B, IL6, and IL8 gene promoters and their corresponding mRNA levels, such inverse correlation was more significant for IL1B (i.e., all cancer cell lines used in this study had a hypermethylated IL1B promoter which was associated with silencing of the gene). | 22923190 |
| Carcinoma of lung | Epigenetic Alterations | Our results underline for the first time the role of epigenetic modifications in the regulation of the expression of key cytokines involved in the inflammatory response during lung cancer development. | 22923190 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | To determine the role of DNA methylation in the progression of acute myeloid leukaemia (AML), we analysed the methylation status of ALOX12, GSTM1, HS3ST2 and FZD9 in 127 AML patients. | 22924777 |
| Neuroendocrine Tumors | Epigenetic Alterations | Altered expression of microRNA miR-21, miR-155, and let-7a and their roles in pulmonary neuroendocrine tumors. | 22924844 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA) has a critical effect on tumorigenesis through post-transcriptional modification and is considered to be potential biomarkers for cancer diagnosis and treatment monitoring. | 22924844 |
| Ovarian Carcinoma | Epigenetic Alterations | MicroRNA expression in ovarian carcinoma and its correlation with clinicopathological features. | 22925189 |
| Malignant neoplasm of ovary | Epigenetic Alterations | MicroRNA (miRNA) expression is known to be deregulated in ovarian carcinomas. | 22925189 |
| Malignant neoplasm of ovary, ovarian neoplasm | Epigenetic Alterations | However, limited data is available about the miRNA expression pattern for the benign or borderline ovarian tumors as well as differential miRNA expression pattern associated with histological types, grades or clinical stages in ovarian carcinomas. | 22925189 |
| ovarian neoplasm | Epigenetic Alterations | Aberrant expression of miRNAs is common in ovarian tumor suggesting involvement of miRNA in ovarian tumorigenesis. | 22925189 |
| Carcinoma | Epigenetic Alterations | Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. | 22925189 |
| Carcinoma | Epigenetic Alterations | An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues. | 22925189 |
| Malignant neoplasm of ovary | Epigenetic Alterations | Among ovarian carcinomas, expression of four miRNAs (miR-30a-3p, miR-30c, miR-30d, miR-30e-3p) was lowest in mucinous and highest in clear cell samples. | 22925189 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | CpG island hypermethylation of gene promoters and regulatory regions is a well-known mechanism of epigenetic silencing of tumor suppressors and is directly linked to carcinogenesis. | 22925896 |
| Breast Carcinoma | Epigenetic Alterations | Circulating microRNAs in plasma as early detection markers for breast cancer. | 22927033 |
| Breast Carcinoma | Epigenetic Alterations | We profiled miRNAs extracted from the plasma of early stage breast cancer patients (taken at the time-point of diagnosis) and healthy control individuals using TaqMan low-density arrays (TLDA). | 22927033 |
| Breast Carcinoma | Epigenetic Alterations | Four miRNAs (miR-148b, miR-376c, miR-409-3p and miR-801) were shown to be significantly upregulated in the plasma of breast cancer patients. | 22927033 |
| Breast Carcinoma | Epigenetic Alterations | In conclusion, the identified miRNAs might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer. | 22927033 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations, such as CpG islands methylation and histone modifications, are recognized key characteristics of cancer. | 22927297 |
| Neoplasms | Epigenetic Alterations | Glycogenes are a group of genes which epigenetic status was found to be changed in several tumors. | 22927297 |
| Prostate Cancer Pathway | Epigenetic Alterations | Genistein suppresses prostate cancer growth through inhibition of oncogenic microRNA-151. | 22928040 |
| Meningioma, Neoplasms | Epigenetic Alterations | We conclude that hypermethylation of the promoter of hMLH1 is an epigenetic change in meningiomas and is associated with the tumor grade, while microsatellite instability is an uncommon event in meningiomas. | 22930430 |
| Breast Carcinoma | Epigenetic Alterations | Aberrant DNA methylation constitutes a well-established epigenetic marker for breast cancer. | 22930747 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Agilent Human miRNA Microarray 16.0 was used to detect the expression of micro-RNAs in paraffin-embedded tissue of 24 cases of DLBCL that had available clinical follow-up. | 22932402 |
| Malignant Neoplasms, Breast Carcinoma | Epigenetic Alterations | Dysregulation of microRNAs is a common feature in human cancers, including breast cancer (BC). | 22935141 |
| Squamous cell carcinoma, SERPINB3 wt Allele | Epigenetic Alterations | Epigenetic silencing of cancer-related genes plays an important role in oral/oropharyngeal squamous cell carcinoma (OSCC). | 22936053 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Association of polymorphisms in microRNA-binding sites and colorectal cancer in an Iranian population. | 22939228 |
| Clinical Coordinator | Epigenetic Alterations | Finally, we can conclude that a significant relationship exists between the miRNA-binding site polymorphism of the IL-16 gene and CRC risk in the Iranian population. | 22939228 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are agents of post-transcriptional gene expression, and they can affect many functions of an individual cell or tissue from extracellular matrix production to inflammatory processes and tumor development. | 22939228 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101. | 22943841 |
| Atrial Fibrillation | Epigenetic Alterations | [Differential expressions of miRNAs in patients with nonvalvular atrial fibrillation]. | 22944230 |
| Atrial Fibrillation | Epigenetic Alterations | To detect the differential expressions of miRNAs in left atrial appendage (LAA) in patients with atrial fibrillation (AF). | 22944230 |
| Degenerative polyarthritis | Epigenetic Alterations | Serum non-coding RNAs as biomarkers for osteoarthritis progression after ACL injury. | 22944527 |
| Cartilage damage | Epigenetic Alterations | This study suggests serum non-coding RNAs may serve as novel noninvasive biomarkers for the detection and assessment of cartilage damage after ACL injury. | 22944527 |
| Cartilage damage | Epigenetic Alterations | Initial TaqMan array miRNA profiling showed an increased serum concentration of a small nucleolar RNA (snoRNA), U48, in five patients with cartilage damage compared with that in five patients without cartilage damage and six normal donors. | 22944527 |
| Carcinogenesis | Epigenetic Alterations | Sarco (endo)plasmic reticulum Ca(2+)-ATPase (SERCAs) 3 is involved in calcium mobilization from endoplasmic reticulum into cytosol and closely links to metabolism, neuronal plasticity, gene transcription, cell growth, differentiation, apoptosis, protein folding, and carcinogenesis. | 22948776 |
| Carcinogenesis | Epigenetic Alterations | MicroRNA is a naturally occurring class of non-coding RNA molecules that mediate posttranscriptional gene regulation and are strongly implicated in cellular processes such as cell proliferation, carcinogenesis, cell survival and apoptosis. | 22954303 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer. | 22954303 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | We profiled the expression of 671 miRNAs in formalin fixed paraffin embedded tumors from patients with advanced bladder cancer treated with cisplatin based chemotherapy. | 22954303 |
| Neoplasms | Epigenetic Alterations | We delineated differentially expressed miRNAs in tumors from patients with complete response vs. patients with progressive disease and in tumors form patients with short and long overall survival time. | 22954303 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Furthermore, we studied the effect of up- and down regulation of key miRNAs on the cisplatin sensitivity in eight bladder cancer cell lines with different sensitivities to cisplatin. | 22954303 |
| Neoplasms | Epigenetic Alterations | MicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours. | 22954417 |
| Stomach Carcinoma | Epigenetic Alterations | Thus, we hypothesised that the quantitative detection of the miR-200 family as epithelial-specific microRNAs in the blood could be a useful clinical biomarker for gastric cancer (GC). | 22954417 |
| Admitting diagnosis | Epigenetic Alterations | Thus, epigenetic mechanisms that regulate gene expression might have an important role in AD. | 22954668 |
| Neoplasms | Epigenetic Alterations | We aimed to estimate the prognostic value of DNA methylation of tumor suppressor genes from pleural fluid. | 22954699 |
| Neoplastic disease | Epigenetic Alterations | Although epigenetic changes are commonly related to human neoplasia, scarce date is available on patients with MPE. | 22954699 |
| Psychotic Disorders | Epigenetic Alterations | DNA methylation/demethylation network expression in psychotic patients with a history of alcohol abuse. | 22958170 |
| Schizophrenia, Bipolar Disorder, Psychotic Disorders | Epigenetic Alterations | We recently reported that DNA methylation dynamics are altered in brains of psychotic (PS) patients, including schizophrenia and bipolar disorder patients. | 22958170 |
| Psychotic Disorders | Epigenetic Alterations | Additional investigation may also be necessary to determine whether the altered DNA methylation dynamics are direct or the consequence of an indirect interaction of alcohol with the neuropathogenetic mechanisms underlying psychosis. | 22958170 |
| Chronic Kidney Diseases | Epigenetic Alterations | Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). | 22960330 |
| Chronic Kidney Diseases | Epigenetic Alterations | We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. | 22960330 |
| Chronic Kidney Diseases | Epigenetic Alterations | Our results suggest that urinary miRNA profiling has the potential of further development as biomarkers of CKD. | 22960330 |
| Chronic Kidney Diseases | Epigenetic Alterations | Micro-RNA expression in the urinary sediment of patients with chronic kidney diseases. | 22960330 |
| cervical cancer | Epigenetic Alterations | Clinico-epigenetic combination including quantitative methylation value of DKK3 augments survival prediction of the patient with cervical cancer. | 22961207 |
| Cervix carcinoma | Epigenetic Alterations | We assessed the quantitative methylation levels of DKK3 in cervical carcinoma, determined the potential clinical correlations, and tested whether the combination of clinical and epigenetic factors augmented the prediction power of prognosis. | 22961207 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Cell-free microRNAs in urine as diagnostic and prognostic biomarkers of bladder cancer. | 22961325 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Urinary cell-free miRNAs show promise as noninvasive biomarkers for diagnosis and recurrence of bladder cancer. | 22961325 |
| Stomach Carcinoma | Epigenetic Alterations | Aberrant DNA methylation is implicated in the epigenetic field defect seen in gastric cancer. | 22961779 |
| Stomach Carcinoma | Epigenetic Alterations | Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer. | 22961779 |
| Stomach Carcinoma | Epigenetic Alterations | Collectively, our data suggest that RASGRF1 methylation is significantly involved in an epigenetic field defect in the stomach, and that it could be a useful biomarker to identify individuals at high risk for gastric cancer. | 22961779 |
| Carcinoma of lung | Epigenetic Alterations | DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer. | 22962272 |
| Lung Neoplasms | Epigenetic Alterations | These findings clearly show the impact of DNA methylation-based assays in the diagnosis of cytologically occult lung neoplasms. | 22962272 |
| Meningioma | Epigenetic Alterations | We propose that this gene repression may be caused by gene promoter hypermethylation, as in the case of UCHL1 and SFRP1, suggesting that this epigenetic event, together with loss of specific chromosomal regions, may play an important role in meningioma progression and recurrence. | 22964784 |
| Colorectal Carcinoma | Epigenetic Alterations | Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas. | 22966016 |
| Clinical Coordinator | Epigenetic Alterations | Several dietary and lifestyle factors can modulate DNA methylation suggesting that they may influence CRC risk through epigenetic regulation of cancer-related genes. | 22966878 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | [DNA methylation status of RARb2 and p16(INK4a) in peripheral blood and tumor tissue in patients with esophageal squamous cell carcinoma]. | 22967446 |
| Antilymphocyte Serum | Epigenetic Alterations | Compared to healthy controls, miRNA 23a, 29b, 206 and 455 were increased in skeletal muscle of ALS patients. | 22975021 |
| Amyotrophic Lateral Sclerosis | Epigenetic Alterations | Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis. | 22975021 |
| Abnormality of mitochondrial metabolism, Antilymphocyte Serum | Epigenetic Alterations | These results show that skeletal muscle mitochondrial dysfunction in ALS patients is associated with a reduction in PGC-1a signalling networks involved in mitochondrial biogenesis and function, as well as increases in several miRNAs potentially implicated in skeletal muscle and neuromuscular junction regeneration. | 22975021 |
| Paraganglioma of head and neck | Epigenetic Alterations | Identification of a signaling axis HIF-1a/microRNA-210/ISCU independent of SDH mutation that defines a subgroup of head and neck paragangliomas. | 22977270 |
| Neoplasms | Epigenetic Alterations | To get some insights into the hypoxic/pseudohypoxic molecular basis of HNPGLs, we attempted to define the gene, microRNA (miRNA), and HIF-1a expression patterns that distinguish tumors from normal paraganglia tissue. | 22977270 |
| Cerebrovascular accident, Hypertensive disease | Epigenetic Alterations | Metalloproteins and metals play key roles in epigenetic events in living organisms, including hypertension, the most important modifiable risk factor for stroke. | 22983496 |
| Endometrial Endometrioid Adenocarcinoma | Epigenetic Alterations | Diagnostic and prognostic significance of miRNA signatures in tissues and plasma of endometrioid endometrial carcinoma patients. | 22987275 |
| Neoplasms | Epigenetic Alterations | Two miRNA signatures: miR-92a/miR-410 and miR-92a/miR-205/miR-410 classified tumor tissues with higher accuracy in comparison to single miRNAs (AUC: 0.977, 95% CI: 0.927-0.996 and 0.984, 95% CI: 0.938-0.999, respectively). | 22987275 |
| Colorectal Carcinoma | Epigenetic Alterations | Genetic and epigenetic factors in regulation of microRNA in colorectal cancers. | 22989523 |
| Malignant Neoplasms | Epigenetic Alterations | Studies on miRNA profiling revealed that a large number of them are significantly deregulated in human cancers. | 22989523 |
| Neoplasms | Epigenetic Alterations | Like miRNAs, snoRNAs are globally down-regulated in tumor cells compared with their normal counterparts. | 22990019 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer. | 22990173 |
| Clinical Coordinator | Epigenetic Alterations | This study showed the most sensitive epigenetic markers, E-cadherin (60 %), followed by APC (57 %), for detecting CRC. | 22990173 |
| Clinical Coordinator | Epigenetic Alterations | In this study, E-cad and APC genes may be particularly useful epigenetic biomarkers in plasma for the detection of CRC. | 22990173 |
| Hollings Cancer Center | Epigenetic Alterations | We previously demonstrated that deregulation of epigenetic regulators is a common event in human HCC. | 22991213 |
| Adenomatous Polyposis Coli, Antigen-Presenting Cells, Neoplasms, Malignant neoplasm of urinary bladder | Epigenetic Alterations | Epigenetic alterations of adenomatous polyposis coli (APC), retinoic acid receptor beta (RARb) and survivin genes in tumor tissues and voided urine of bladder cancer patients. | 22992440 |
| Reduced | Epigenetic Alterations | Our results suggest that a total (cytogenetic and epigenetic) functional loss of both EMP3 alleles accounts for the reduced disease progression-free interval in OII patients. | 22992787 |
| Childhood Leukemia | Epigenetic Alterations | Oncogenic Bmi-1 (B-lymphoma Moloney murine leukemia virus insertion region-1) belongs to the Polycomb-group (PcG) family of proteins and plays an important role in the regulation of proliferation, senescence, cell cycle and apoptosis, chromosome stability, activation of gene transcription. | 22994774 |
| Clinical Coordinator | Epigenetic Alterations | Our integrative genomic and epigenetic analysis suggests early onset of CIMP during CRC development and indicates a previously unknown CRC development pathway in which epigenetic instability associates with genomic alterations. | 22995252 |
| Stomach Carcinoma | Epigenetic Alterations | Prognostic implications for high expression of oncogenic microRNAs in advanced gastric carcinoma. | 22996433 |
| Malignant Neoplasms, Stomach Carcinoma | Epigenetic Alterations | Aberrant expressions of specific microRNAs are recently known in many malignancies, including gastric carcinoma. | 22996433 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Stage, grade and behavior of bladder urothelial carcinoma defined by the microRNA expression profile. | 22999546 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | We identified miRNA expression profiles in urothelial carcinoma that are associated with grade, stage, and recurrence-free and disease specific survival. | 22999546 |
| Neoplasms | Epigenetic Alterations | The other miRNAs were present at levels similar to those of normal bladder tissue or under expressed in each tumor group. | 22999546 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | Four miRNAs were differentially expressed in the 2 urothelial carcinoma groups. | 22999546 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | miRNAs could be incorporated into the urothelial carcinoma molecular pathway. | 22999546 |
| Squamous Cell Carcinoma of the Penis | Epigenetic Alterations | Histone methylation defines an epigenetic entity in penile squamous cell carcinoma. | 22999995 |
| Carcinogenesis | Epigenetic Alterations | Histone methylation patterns are frequently altered during carcinogenesis. | 22999995 |
| Primary malignant neoplasm | Epigenetic Alterations | Histone methylation levels defined an epigenetic entity that allowed accurate differentiation of cancer and normal samples. | 22999995 |
| Penis carcinoma | Epigenetic Alterations | The description of a definite epigenetic entity in penile carcinoma provides a rationale for testing epigenetic agents in patients with metastatic disease. | 22999995 |
| Carcinogenesis | Epigenetic Alterations | Adequate folate status may protect against colorectal carcinogenesis through mechanisms involving adequate DNA methylation in the genome. | 23001241 |
| Epstein-Barr virus associated gastric carcinoma | Epigenetic Alterations | Epigenetic silencing of WNT5A in Epstein-Barr virus-associated gastric carcinoma. | 23001722 |
| SF3B1 wt Allele | Epigenetic Alterations | The Dab2 gene is inactivated in MDS in part by DNA methylation, and the suppression of Dab2 expression by DNA methylation may play a role in the development of MDS. | 23005040 |
| Stomach Carcinoma | Epigenetic Alterations | Identification of recurrence-related genes by integrating microRNA and gene expression profiling of gastric cancer. | 23007704 |
| Primary malignant neoplasm | Epigenetic Alterations | We previously analyzed the microRNA (miRNA) expression pattern in gastric cancer with and without recurrence and obtained 17 differentially expressed miRNAs with potential to predict recurrence risk for GC patients. | 23007704 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Tumor samples from 155 patients with stages IIIB to IV NSCLC who received EGFR-TKI therapy were analyzed for DNA methylation status of Wnt antagonist genes, including SFRP1, SFRP2, SFRP5, DKK3, WIF1, and APC, using methylation specific PCR (MSP) method. | 23009178 |
| Clinical Coordinator, Carcinogenesis | Epigenetic Alterations | DNA methylation is a common event in CRC where it is now considered an important phenomenon in CRC carcinogenesis and useful for the classification and prognosis of CRC. | 23010642 |
| Clinical Coordinator | Epigenetic Alterations | To gain insight into the molecular mechanisms underpinning CRC in Saudi Arabian patients, we profiled the DNA methylation frequency of key genes (MLH1, MSH2, RASSF1A, SLIT2, HIC1, MGMT, SFRP1, MYOD1, APC, CDKN2A, as well as five CIMP markers) in 120 sporadic CRC cases. | 23010642 |
| Malignant Neoplasms, Primary malignant neoplasm, Squamous cell carcinoma of esophagus | Epigenetic Alterations | The association of microRNAs (miRs) with cancer progression has been established in many cancers including esophageal squamous cell carcinoma (ESCC). | 23013135 |
| Endometrial adenocarcinoma | Epigenetic Alterations | Quantitative assessment of DNA methylation for the detection of cervical and endometrial adenocarcinomas in liquid-based cytology specimens. | 23016466 |
| Cervical Intraepithelial Neoplasia | Epigenetic Alterations | Methylated DNA Immunoprecipitation (MeDIP) combined with DNA microarray was used to compare DNA methylation profiles of epithelial cells derived from high-grade CIN lesions with normal cervical epithelium. | 23018867 |
| Cervical Intraepithelial Neoplasia | Epigenetic Alterations | In conclusion, our newly identified hypermethylated DMRs represent specific DNA methylation patterns in high-grade CIN lesions and are candidate biomarkers for early detection. | 23018867 |
| cervical cancer | Epigenetic Alterations | Epigenetic modifications, such as aberrant DNA promoter methylation, are frequently observed in cervical cancer. | 23018867 |
| Aneuploidy, Chordoma, Neoplasms | Epigenetic Alterations | Our data suggest that chromosome 3 aneuploidy and epigenetic regulation of FHIT contribute to loss of the FHIT tumor suppressor in chordoma. | 23019410 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Acute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene. | 23022987 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Acute myeloid leukemia (AML) with t(8;16)(p11;p13) (t(8;16) AML) has unique clinico-biological characteristics, but its microRNA pattern is unknown. | 23022987 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | However, there was no difference in methylation status between t(8;16) and other AML subtypes, either overall or in the microRNA promoter. | 23022987 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | In conclusion, t(8;16) AML harbors a specific microRNA signature that is partially epigenetically regulated and targets RET proto-oncogene. | 23022987 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | We analyzed 670 microRNAs in seven patients with t(8;16) AML and 113 with other AML subtypes. | 23022987 |
| Primary malignant neoplasm | Epigenetic Alterations | Cancer cells exhibit 2 types of deoxyribonucleic acid (DNA) methylation alterations: global DNA hypomethylation and site-specific CpG island promoter hypermethylation. | 23023202 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) have increasingly been implicated in regulating the malignant progression of cancer. | 23023232 |
| Colorectal Cancer Pathway | Epigenetic Alterations | microRNA-181a is associated with poor prognosis of colorectal cancer. | 23023298 |
| Prostatic Neoplasms | Epigenetic Alterations | Collectively, these results indicate that histone modifications can contribute to TIMP3 repression in the absence of promoter hypermethylation, and suggest that the combination of histone modifying agents could restore TIMP3 expression in prostate tumors harboring aberrant histone modifications at the TIMP3 promoter. | 23023649 |
| Prostate Cancer Pathway | Epigenetic Alterations | Heterogeneous epigenetic regulation of TIMP3 in prostate cancer. | 23023649 |
| Prostate Cancer Pathway | Epigenetic Alterations | The mechanisms involved in TIMP3 transcriptional repression are not fully understood, but evidence suggests that promoter hypermethylation may not be the predominant epigenetic alteration in prostate cancer. | 23023649 |
| Acute Coronary Syndrome | Epigenetic Alterations | Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs. | 23023917 |
| CO-methylating acetyl-CoA synthase activity | Epigenetic Alterations | Circulating microRNAs hold great potential as novel early biomarkers for the management of suspected ACS patients. | 23023917 |
| cervical cancer | Epigenetic Alterations | Post-transcriptional and epigenetic regulation of antigen processing machinery (APM) components and HLA-I in cervical cancers from Uighur women. | 23024775 |
| Primary malignant neoplasm | Epigenetic Alterations | The posttranscriptional regulation of HLA-I and APM expression may associate with epigenetic modifications in cancer development which was not described so far. | 23024775 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Our results suggested that epigenetic modifications are responsible for the aberrant expression of certain HLA-I and APM genes, and may help to understand unrevealed mechanisms of tumor escape from immune surveillance in cervical carcinogenesis. | 23024775 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs have been shown to be dysregulated in a variety of cancers. | 23026055 |
| Septicemia | Epigenetic Alterations | Four serum microRNAs identified as diagnostic biomarkers of sepsis. | 23026916 |
| Septicemia | Epigenetic Alterations | Four serum miRNAs were identified as novel biomarkers of sepsis. | 23026916 |
| Disease | Epigenetic Alterations | In addition, we identified two robust miSNPs x 3utrSNPs interactions, one involving HLA-DPB1 rs1042448 and hsa-mir-219-1 rs107822, the second the H1F0 rs1894644 and hsa-mir-659 rs5750504, modulating the expression of the associated genes.As some of the aforementioned genes have previously been reported to reside at disease-associated loci, our findings provide novel arguments supporting the hypothesis that the genetic variability of miRNAs could also contribute to the susceptibility to human diseases. | 23029284 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | We determined the expression of ITGAL, PRF1, KIR2DL4, CD70, and CD40LG in patients with SLE and performed correlations with the global DNA methylation status and the levels of three DNA methylation enzymes and two methyl CpG-binding domain (MBD) proteins. | 23029299 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | MicroRNA expression profiles of whole blood in lung adenocarcinoma. | 23029380 |
| Carcinoma of lung | Epigenetic Alterations | The association of lung cancer with changes in microRNAs in plasma shown in multiple studies suggests a utility for circulating microRNA biomarkers in non-invasive detection of the disease. | 23029380 |
| Carcinoma of lung | Epigenetic Alterations | These results suggest that whole blood microRNA expression profiles can be used to distinguish lung cancer cases from clinically relevant controls. | 23029380 |
| Neoplasms | Epigenetic Alterations | The epigenetic silencing of tumor suppressor genes plays an important role in gliomagenesis. | 23032906 |
| Glioblastoma Multiforme | Epigenetic Alterations | The present work demonstrated that the epigenetic inactivation of TFPI-2 by promoter hypermethylation was a frequent and tumor-specific event in glioblastoma, and TFPI-2 promoter methylation might be considered as a prognostic marker in glioblastoma. | 23032906 |
| Malignant Neoplasms | Epigenetic Alterations | A quantitative Malignancy Index Diagnostic System (qMIDS) was developed based on 14 FOXM1 (isoform B)-associated genes implicated in the regulation of the cell cycle, differentiation, ageing, genomic stability, epigenetic and stem cell renewal, and two reference genes. | 23034676 |
| Carcinoma of lung, quercetin | Epigenetic Alterations | Influence of quercetin-rich food intake on microRNA expression in lung cancer tissues. | 23035181 |
| Autoimmune Thyroid Disease Pathway | Epigenetic Alterations | Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease. | 23039890 |
| Autoimmune thyroid disease | Epigenetic Alterations | To clarify the association between factors regulating DNA methylation and the prognosis of autoimmune thyroid diseases (AITDs), we genotyped single nucleotide polymorphisms in genes encoding DNA methyltransferase 1 (DNMT1), DNMT3A, DNMT3B, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), which are enzymes essential for DNA methylation. | 23039890 |
| Carcinoma of lung | Epigenetic Alterations | Two microRNA panels to discriminate three subtypes of lung carcinoma in bronchial brushing specimens. | 23043084 |
| Small cell carcinoma of lung, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The microRNA panels were applied as differentiators of SCLC from NSCLC and of SQ from AC in 207 bronchial brushing specimens. | 23043084 |
| Small cell carcinoma of lung, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Two microRNA panels yielded high diagnostic accuracy in discriminating SCLC from NSCLC (miR-29a and miR-375; area under the curve [AUC], 0.991 and 0.982 for training and validation data set, respectively) and in differentiating SQ from AC (miR-205 and miR-34a; AUC, 0.977 and 0.982 for training and validation data set, respectively) in FFPE surgical lung specimens. | 23043084 |
| Small cell carcinoma of lung, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Moreover, the microRNA panels accurately differentiated SCLC from NSCLC (AUC, 0.947) and SQ from AC (AUC, 0.962) in bronchial brushing specimens. | 23043084 |
| Carcinoma of lung | Epigenetic Alterations | We found two microRNA panels that accurately discriminated between the three subtypes of lung carcinoma in bronchial brushing specimens. | 23043084 |
| Carcinoma of lung | Epigenetic Alterations | The identified microRNA panels may have considerable clinical value in differential diagnosis and optimizing treatment strategies based on lung cancer subtypes. | 23043084 |
| Primary malignant neoplasm | Epigenetic Alterations | Microarrays were used to screen 723 microRNAs in laser-captured, microdissected cancer cells from 82 snap-frozen surgical lung specimens. | 23043084 |
| Malignant Neoplasms | Epigenetic Alterations | MiRNA profiling is an emerging tool for the potential early detection of a variety of malignancies. | 23043708 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The five optimized miRNAs accurately clustered these eight retrospective patients into NSCLC positive cases and negative controls. | 23043708 |
| ovarian neoplasm | Epigenetic Alterations | We compared miRNA expression profiles of an isogenic cisplatin-sensitive and -resistant ovarian cancer cell line pair (A2780/A2780 DDP) and found 27 miRNAs to be differentially expressed (2-fold). | 23045278 |
| Disease | Epigenetic Alterations | Circulating microRNAs (miRNAs) have emerged as new biomarkers for human diseases. | 23051042 |
| Carcinoma of lung | Epigenetic Alterations | Epigenetic modifications are observed universally during the tumorigenesis of lung cancer. | 23053268 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The development of epigenetic-modulating agents utilizing the synergism between hypomethylating agents and histone deacetylase (HDAC) inhibitors provides a novel therapeutic approach in treating NSCLC. | 23053268 |
| Carcinogenesis | Epigenetic Alterations | DNA-methyltransferase (DNMT)-3A plays a crucial role in embryonic development and aberrant DNA methylation in carcinogenesis. | 23053986 |
| SF3B1 wt Allele | Epigenetic Alterations | Our results provide further evidence for the involvement of epigenetic dysregulation in the pathogenesis of MDS. | 23055192 |
| Neoplasms, Malignant Neoplasms, Malignant - descriptor, Carcinoma, Ovarian Epithelial, Carcinoma | Epigenetic Alterations | The aim of this study was to assess the extent of methylation of the RASSF1A and APC TSG promoters in ovarian epithelial adenomas, low malignant potential tumours and carcinomas in order to reveal a role for epigenetic TSG silencing in the development of these ovarian malignancies. | 23055343 |
| Carcinoma, Cystadenoma, Neoplasms | Epigenetic Alterations | The observed aberrant methylation frequencies of the RASSF1A and APC gene promoters indicate that an accumulation of epigenetic events at these specific TSG promoters may be associated with the malignant transformation of benign cystadenomas and LMP tumours to carcinomas. | 23055343 |
| Bladder Neoplasm | Epigenetic Alterations | Aberrant DNA methylation is present in all bladder tumors and can be detected in urine specimens. | 23056278 |
| Clinical Coordinator | Epigenetic Alterations | We aimed to determine whether expression status of certain miRNAs might have prognostic/predictive value in CRC patients treated with conventional cytotoxic chemotherapies. | 23056401 |
| Clinical Coordinator | Epigenetic Alterations | Among the candidate miRNAs studied, miR-148a expression was most significantly down-regulated in advanced CRC tissues. | 23056401 |
| Cell of Claudius, Neoplasms | Epigenetic Alterations | In summary, the WNT7A gene is inactivated by genetic/epigenetic alterations in clear cell RCC and demonstrates tumor suppressor properties. | 23056560 |
| Breast Carcinoma, NCOA5 gene | Epigenetic Alterations | CIA identified miR-187 as a key miRNA associated with poor outcome in breast cancer. | 23060431 |
| Glioblastoma Multiforme | Epigenetic Alterations | Plasma micro-RNA-21 may be associated with glioblastoma development in individual cases. | 23061753 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | We have also recognized a DNA methylation signature that distinguishes new clinico-biological subtypes of CLL. | 23064414 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | The two molecular subtypes of CLL have differing DNA methylomes that seem to represent epigenetic imprints from distinct normal B-cell subpopulations. | 23064414 |
| Leukemia, Myelomonocytic, Chronic | Epigenetic Alterations | We found that myelodysplastic chronic myelomonocytic leukemias are characterized by mutations in transcription/epigenetic regulators (ASXL1, RUNX1, TET2) and splicing genes (SRSF2) and the absence of mutations in signaling genes. | 23065512 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | A polymorphism in the 3-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia. | 23065518 |
| nucleophosmin, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Together, our findings uncover a microRNA-mediated control of NPM1 expression that contributes to disease heterogeneity and suggest additional prognostic values of NPM1 in acute myeloid leukemia. | 23065518 |
| Myeloproliferative disease | Epigenetic Alterations | Even though mutations in epigenetic regulators frequently occur in myeloproliferative neoplasms, their effects on the epigenome have not been well studied. | 23066032 |
| JAK2 NP_004963.1:p.V617F | Epigenetic Alterations | In contrast, the JAK2V617F mutation did not drive epigenetic clustering within MPNs. | 23066032 |
| PRB1 gene, Thrombocytosis, Polycythemia | Epigenetic Alterations | These results show epigenetic differences between PMF and polycythemia vera/essential thrombocytosis and reveal methylomic signatures of ASXL1 and TET2 mutations. | 23066032 |
| Cardiovascular Diseases | Epigenetic Alterations | MicroRNAs (miRNAs) act by targeting 3-UTR mRNA, causing translational repression in physiological and pathological conditions, including cardiovascular diseases. | 23066896 |
| Breast Carcinoma | Epigenetic Alterations | Serum microRNA-155 as a potential biomarker to track disease in breast cancer. | 23071695 |
| Primary malignant neoplasm | Epigenetic Alterations | A growing body of evidence implicates the diagnostic potential of circulating miRNAs in cancer detection. | 23071695 |
| Hemolytic-Uremic Syndrome | Epigenetic Alterations | Circulating microRNAs in patients with Shiga-Toxin-producing E. coli O104:H4 induced hemolytic uremic syndrome. | 23071762 |
| Neurologic Symptoms | Epigenetic Alterations | Circulating microRNAs are strongly altered in this patient cohort and associated with neurological symptoms as well as platelet count. | 23071762 |
| Primary Neoplasm, Magnetic-Targeted Carriers, Metastasis | Epigenetic Alterations | Nodal metastasis microRNA expression correlates with the primary tumour in MTC. | 23072640 |
| Primary Neoplasm, Magnetic-Targeted Carriers | Epigenetic Alterations | miRNA expression patterns in nodal metastases significantly reflect those of the primary tumour in MTC. | 23072640 |
| Clinical Coordinator | Epigenetic Alterations | In addition to genetic aberrations, DNA methylation also plays important roles in the development of CRC. | 23073979 |
| Neoplasms | Epigenetic Alterations | Tumors with frequent DNA methylation were most strongly enriched in subgroups with infrequent CNAs. | 23073979 |
| Epstein-Barr virus associated gastric carcinoma | Epigenetic Alterations | Role of DNA methylation in the development of Epstein-Barr virus-associated gastric carcinoma. | 23073987 |
| Epstein-Barr virus associated gastric carcinoma, Neoplasms | Epigenetic Alterations | DNA methylation of tumor suppressor genes that regulate the cell cycle and apoptosis specifically occurred in EBV-associated gastric carcinomas. | 23073987 |
| Epstein-Barr virus associated gastric carcinoma | Epigenetic Alterations | Aberrant DNA methylation might lead to the development and progression of EBV-associated gastric carcinoma. | 23073987 |
| Malignant tumor of colon | Epigenetic Alterations | Genetic and epigenetic factors affecting DNA methylation and gene expression are known to be involved in the development of colon cancer, but the full range of genetic alterations and many key genes involved in the pathogenesis of colon cancer remain to be identified. | 23079973 |
| Hepatitis B Virus-Related Hepatocellular Carcinoma | Epigenetic Alterations | Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma. | 23082062 |
| Hepatitis B, Hollings Cancer Center | Epigenetic Alterations | To identify the differentially expressed miRNAs and their targets in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). | 23082062 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Detecting DNA methylation of the BCL2, CDKN2A and NID2 genes in urine using a nested methylation specific polymerase chain reaction assay to predict bladder cancer. | 23083854 |
| Malignant neoplasm of urinary bladder, Primary malignant neoplasm | Epigenetic Alterations | As urine is easily attainable, bladder cancer is an optimal cancer to detect using DNA methylation. | 23083854 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is highly specific in cancer detection. | 23083854 |
| Hepatitis B | Epigenetic Alterations | Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle. | 23091627 |
| ovarian neoplasm | Epigenetic Alterations | We conclude that Nanog, which probably plays an important role in ovarian embryonic development, may be partially silenced in fertile and post-menopausal women, but is re-expressed in ovarian cancer, probably by epigenetic activation of Nanog gene expression. | 23092806 |
| SF3B1 wt Allele | Epigenetic Alterations | Our results indicate that epigenetic regulation of the Wnt pathway in MDS cell line, and the methylation status of Wnt antagonists predicts prognoses of MDS patients. | 23093371 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is a mechanism for gene expression silencing in cancer. | 23093492 |
| Carcinoma | Epigenetic Alterations | Unsupervised clustering of DNA methylation profiles identified two groups of carcinomas, one with an elevated methylation level, evoking a CpG island methylator phenotype (CIMP). | 23093492 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Changes in DNA methylation, whether hypo- or hypermethylation, have been shown to be associated with the progression of colorectal cancer. | 23096130 |
| Carcinoma, Adenoma | Epigenetic Alterations | Widespread changes in DNA methylation are seen in the transition from adenoma to carcinoma. | 23096130 |
| Malignant neoplasm of liver | Epigenetic Alterations | The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing. | 23097274 |
| Neoplasms | Epigenetic Alterations | Lin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. | 23097274 |
| Hollings Cancer Center | Epigenetic Alterations | Our results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins. | 23097274 |
| Refractory Colorectal Carcinoma | Epigenetic Alterations | MicroRNA profiling predicts survival in anti-EGFR treated chemorefractory metastatic colorectal cancer patients with wild-type KRAS and BRAF. | 23098991 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Somatic mutations of epigenetic gene regulators are common in patients with myelodysplastic syndromes (MDS) and correlate with some clinical and laboratory features. | 23099237 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Correlation of microRNA-375 downregulation with unfavorable clinical outcome of patients with glioma. | 23103713 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNA-375 (miR-375) is frequently demonstrated to be frequently dysregulated and functions as a tumor suppressor or an oncogene in different cancer types. | 23103713 |
| Glioma | Epigenetic Alterations | This miRNA might function as a candidate unfavorable prognostic marker for human gliomas. | 23103713 |
| Breast Carcinoma, Columnar Cell Lesion of the Breast | Epigenetic Alterations | Epigenetic progression of columnar cell lesions of the breast to invasive breast cancer. | 23104224 |
| Carcinogenesis, Columnar epithelial cell, Neoplasms | Epigenetic Alterations | Promoter hypermethylation of several tumour suppressor genes often occurs during breast carcinogenesis, but little is known about epigenetic silencing in the possible precursor columnar cell lesion (CCL). | 23104224 |
| Stomach Carcinoma | Epigenetic Alterations | Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer. | 23107361 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA let-7i has been proven to be down-regulated in many human malignancies and correlated with tumor progression and anticancer drug resistance. | 23107361 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Epigenetic biomarkers of T-cells in human glioma. | 23108258 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | To explore epigenetic influences, promoter methylation of selected tumor suppressor genes was analyzed in early-stage NSCLC patients ranging in age from 30 to 87 years at diagnosis. | 23111194 |
| Cutaneous Melanoma, Carubicin | Epigenetic Alterations | Perturbations in microRNA (miRNA) expression profiles have been reported for cutaneous malignant melanoma (CMM) predominantly when examined in cell lines. | 23111773 |
| Cutaneous Melanoma | Epigenetic Alterations | Despite the rapidly growing number of newly discovered human miRNA sequences, the availability of up-to-date miRNA expression profiles for clinical samples of primary cutaneous malignant melanoma (PCMM), cutaneous malignant melanoma metastases (CMMM), and benign melanocytic nevi (BMN) is limited. | 23111773 |
| Carubicin | Epigenetic Alterations | In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. | 23111773 |
| Carubicin | Epigenetic Alterations | The results of this study partially confirm previous CMM miRNA profiling studies identifying miRNAs that are dysregulated in CMM. | 23111773 |
| Arteriosclerosis | Epigenetic Alterations | Clarification of familial factors associated with DNA methylation and early atherosclerosis will provide important information to uncover clinical correlates of disease. | 23116433 |
| Arteriosclerosis | Epigenetic Alterations | Atherosclerosis is a complex process involving both genetic and epigenetic factors. | 23116433 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Our results emphasize the importance of validating potential tumor markers in independent patient cohorts, and indicate that the role of miRNAs as colorectal cancer biomarkers is still undetermined. | 23121918 |
| Hollings Cancer Center | Epigenetic Alterations | Both KL gene expression and its promoter DNA methylation are predictive factors for the poor prognosis of HCC. | 23123137 |
| Liver carcinoma | Epigenetic Alterations | Epigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma. | 23123137 |
| Carcinogenesis | Epigenetic Alterations | Therefore, our data suggested that inactivation of the FHL1 gene is a frequent event during oral carcinogenesis and that the mechanism of FHL1 downregulation in OSCCs is through DNA methylation of the promoter region rather than histone deacetylation or mutation. | 23123766 |
| Malignant neoplasm of breast | Epigenetic Alterations | HOTAIR expression and DNA methylation were analyzed in tissue from 348 primary breast cancers with quantitative RT-PCR and methylation-specific PCR, respectively. | 23124417 |
| Breast Carcinoma | Epigenetic Alterations | These findings suggest that the intergenic DNA methylation may have important biologic relevance in regulating HOTAIR expression, and that HOTAIR expression may not be an independent prognostic marker in breast cancer, but needs further validation in independent studies. | 23124417 |
| Breast Carcinoma | Epigenetic Alterations | Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer. | 23124417 |
| Primary Neoplasm, Primary malignant neoplasm | Epigenetic Alterations | Global microRNA profiling in favorable prognosis subgroups of cancer of unknown primary (CUP) demonstrates no significant expression differences with metastases of matched known primary tumors. | 23124598 |
| Malignant neoplasm of ovary, Breast Adenocarcinoma, Head and Neck Neoplasms | Epigenetic Alterations | Subsequently, we profiled the expression of 733 microRNAs (miRs) in the CUP cases and compared results with metastases from 20 ovarian carcinomas, 10 breast adenocarcinomas, 20 squamous head neck or lung tumors. | 23124598 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma. | 23124769 |
| Primary malignant neoplasm | Epigenetic Alterations | Tumor-specific microRNAs (miRNAs) seem to be potential biomarkers for the early diagnosis and treatment of cancer. | 23124769 |
| Esophageal carcinoma, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Therefore, there is a set of differentially expressed miRNAs in esophageal cancer which may be associated with the incidence and development of ESCC. | 23124769 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Differential expression profiles of miRNAs in ESCC may be promising biomarkers for the early screening of high-risk populations and early detection. | 23124769 |
| Neoplasms | Epigenetic Alterations | Disturbances in the epigenetic landscape by aberrant methylation of CpG islands can lead to inactivation of cancer-related genes in solid tumors. | 23125005 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. | 23125220 |
| Neoplasms | Epigenetic Alterations | Recently, downregulation of tumor suppressor genes expression by microRNA (miRNA) is increasingly recognized as an important mechanism of nasopharyngeal tumorigenesis. | 23125220 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Epigenetic profile in chronic lymphocytic leukemia using methylation-specific multiplex ligation-dependent probe amplification. | 23130831 |
| Malignant tumor of colon | Epigenetic Alterations | The epigenetic silencing of KiSS-1 by hypermethylation was tested in colon cancer cells (n = 5) before and after azacytidine treatment. | 23132294 |
| Glioblastoma Multiforme | Epigenetic Alterations | Epigenetic silencing of Id4 identifies a glioblastoma subgroup with a better prognosis as a consequence of an inhibition of angiogenesis. | 23132729 |
| Adenoma of large intestine | Epigenetic Alterations | Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas. | 23132835 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Low concentrations of folate, other B vitamins, and methionine are associated with colorectal cancer risk, possibly by changing DNA methylation patterns. | 23132835 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer. | 23133627 |
| Carcinoma of lung | Epigenetic Alterations | We further showed that miR-574-5p was the mostly up-regulated miRNA in human lung cancer cells under TLR9 signaling by miRNA array analysis. | 23133627 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | Here we characterized the potential role of miRNA-574-5p in enhanced tumor progression induced by TLR9 signaling in human lung cancer. | 23133627 |
| Neoplasms | Epigenetic Alterations | Notably, we found that down-regulation of miRNA-574-5p using miR-574-5p inhibitor in vitro or miR-574-5p sponge in vivo significantly abrogated the enhanced tumor progression induced by TLR9 signaling. | 23133627 |
| Neoplasms | Epigenetic Alterations | Notably, we identified checkpoint suppressor 1 (Ches1) as the dominant direct target for miRNA-574-5p to confer the TLR9 signaling enhanced tumor progression. | 23133627 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Our findings not only facilitated the further understanding of the crosstalk between miRNAs and TLRs in tumor biology, but also provided novel potential candidates for treatment of cancer. | 23133627 |
| Myocardium, Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction. | 23137501 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Circulating microRNAs (miRs) have emerged as potential diagnostic markers in patients with myocardial infarction. | 23137501 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Transporter gene expression in human head and neck squamous cell carcinoma and associated epigenetic regulatory mechanisms. | 23137910 |
| Squamous cell carcinoma of the head and neck, Neoplasms | Epigenetic Alterations | In summary, the expression of drug transporters (i) is markedly changed in HNSCC tumor tissues compared with normal mucosa, (ii) might be predictive of the outcome of patients with HNSCC, and (iii) is affected by novel epigenetic therapies and is further modulated by nuclear receptor-mediated mechanisms. | 23137910 |
| Malignant Neoplasms | Epigenetic Alterations | Because PcG-associated aberrant DNA methylation is a hallmark of several human malignancies, our methylation data suggest that epigenetic reprogramming of pluripotency genes may initiate cell immortalization. | 23143272 |
| Primary malignant neoplasm | Epigenetic Alterations | Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization. | 23143272 |
| Primary malignant neoplasm | Epigenetic Alterations | Unlike genetic alterations, epigenetic changes are reversible events, and as such, can be amenable to pharmacological interventions, which makes them appealing targets for cancer therapy when genetic approaches prove inadequate. | 23143272 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | However, studies of direct link between estrogen (especially estradiol E2), miRNA expression, and MMR in colorectal cancer (CRC) have not been done. | 23143558 |
| Breast Carcinoma | Epigenetic Alterations | Independent T-test was used to detect significant correlation between miRNA expression level and the different clinicopathological features for breast cancer. | 23144930 |
| Malignant neoplasm of breast | Epigenetic Alterations | Validation of expression patterns for nine miRNAs in 204 lymph-node negative breast cancers. | 23144930 |
| Humor, Cataract | Epigenetic Alterations | MicroRNA in aqueous humor from patients with cataract. | 23146683 |
| Glaucoma, CTCAE | Epigenetic Alterations | Further analysis of the AH miRNA population may identify potential gene targets and provide insights regarding their roles in AH regulation, glaucoma and anterior segment disease processes. | 23146683 |
| Humor, Cataract | Epigenetic Alterations | We analyzed aqueous humor (AH) from human subjects undergoing cataract surgery to establish the presence and relative quantities of known miRNAs. | 23146683 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | We determined global miRNA expression profiles of RCC and parallel renal parenchyma tissues by using quantitative reverse transcriptase-polymerase chain reaction-based TaqMan low-density arrays. | 23150176 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Functional in vitro experiments were performed on ACHN and CAKI-2 RCC cell lines transfected with miRNA-210 inhibitor. | 23150176 |
| Carcinogenic Chlorinated Hydrocarbon | Epigenetic Alterations | The resulting miRNA expression was compared to the stage or grade of CHC determined by blood examination and histological inspection. | 23152743 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis, Fibrosis, Liver | Epigenetic Alterations | Additionally, we could link miRNA expression pattern with liver fibrosis stage and grade of liver inflammation in CHC. | 23152743 |
| Inflammation | Epigenetic Alterations | In particular, the miRNA expression pattern for early fibrotic stage differed greatly from that observed in high inflammation grades. | 23152743 |
| Liver diseases | Epigenetic Alterations | We demonstrated that miRNA expression pattern in exosome rich fractionated serum shows a high potential as a biomarker for diagnosing the grade and stage of liver diseases. | 23152743 |
| Carcinoma, Transitional Cell, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder. | 23153939 |
| Malignant Neoplasms, SDHB protein, human, Neoplasms | Epigenetic Alterations | Furthermore, a constitutional SDHB mutation is proposed to predispose for an epigenetic tumor phenotype occurring before the emanation of clinically recognized malignancy. | 23154831 |
| Pancreatic carcinoma | Epigenetic Alterations | High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer. | 23155457 |
| Malignant Neoplasms | Epigenetic Alterations | Yes-associated protein (YAP) plays an important role in signal transduction and gene transcription regulation in normal cells, with elevated and over-expressed YAP levels observed in various malignant tumors. | 23158133 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia. | 23158571 |
| Prostate Cancer Pathway | Epigenetic Alterations | We determined whether a novel combination of field defect DNA methylation markers could predict the presence of prostate cancer using histologically normal transrectal ultrasound guided biopsy cores. | 23159584 |
| Prostate Cancer Pathway | Epigenetic Alterations | Using the epigenetic field defect to detect prostate cancer in biopsy negative patients. | 23159584 |
| Prostate Cancer Pathway | Epigenetic Alterations | A widespread epigenetic field defect can be used to detect prostate cancer in patients with histologically negative biopsies. | 23159584 |
| Kidney Failure, Acute | Epigenetic Alterations | MicroRNA-494 reduces ATF3 expression and promotes AKI. | 23160513 |
| Necrosis, Kidney Failure, Acute | Epigenetic Alterations | MicroRNA-494 mediates apoptosis and necrosis in several types of cells, but its renal target and potential role in AKI are unknown. | 23160513 |
| Kidney Failure, Acute | Epigenetic Alterations | In humans, urinary microRNA-494 levels were 60-fold higher in patients with AKI than normal controls. | 23160513 |
| Injury of kidney | Epigenetic Alterations | In conclusion, upregulation of microRNA-494 contributes to inflammatory or adhesion molecule-induced kidney injury after ischemia/reperfusion by inhibiting expression of ATF3. | 23160513 |
| Kidney Failure, Acute | Epigenetic Alterations | Furthermore, microRNA-494 may be a specific and noninvasive biomarker for AKI. | 23160513 |
| Coronary Artery Disease | Epigenetic Alterations | Oxidative stress in coronary artery disease: epigenetic perspective. | 23160801 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic regulation, has been very scarcely explored in familial breast cancer (BC). | 23160909 |
| Breast Carcinoma | Epigenetic Alterations | Different methylation and microRNA expression pattern in male and female familial breast cancer. | 23160909 |
| Colorectal Cancer Pathway, cetuximab | Epigenetic Alterations | Let-7 miRNA-binding site polymorphism in the KRAS 3UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/- cetuximab. | 23167843 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are small non-coding RNAs playing significant roles in the pathogenesis of many cancers including rectal cancer. | 23167930 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA expression profile associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients. | 23167930 |
| Primary malignant neoplasm | Epigenetic Alterations | Our pilot study suggests that miRNAs are part of the mechanisms that are involved in response of rectal cancer to the chemoradiotherapy and that miRNAs may be promising predictive biomarkers for such patients. | 23167930 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | [Urine cardiac specific microRNA-1 level in patients with ST segment elevation acute myocardial infarction]. | 23168196 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | [Changes in cardiac specific microRNA-208a level in peripheral blood in ST segment elevation acute myocardial infarction patients]. | 23168198 |
| Corneal Endothelial Cell Loss | Epigenetic Alterations | [Evaluation of circulating microRNA-92a for endothelial damage induced by percutaneous coronary intervention]. | 23168199 |
| Multiple Myeloma | Epigenetic Alterations | Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma. | 23169280 |
| Multiple Myeloma | Epigenetic Alterations | Three serum microRNAs, miR-720, miR-1308 and miR-1246, were found to have potential as diagnostic biomarkers in myeloma. | 23169280 |
| Multiple Myeloma | Epigenetic Alterations | We have developed a biomarker signature using microRNAs extracted from serum, which has potential as a diagnostic and prognostic tool for multiple myeloma. | 23169280 |
| Myositis | Epigenetic Alterations | This leukocyte index was subsequently utilized to differentiate transcriptional changes due to leukocyte infiltration from other alterations in myositis muscle. | 23171592 |
| Myositis | Epigenetic Alterations | Although the role of miR-146a in myositis remains uncertain, our results highlight the potential benefit of deconvoluting the source of transcriptional changes in myositis muscle or other heterogeneous tissue samples. | 23171592 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNAs are small noncoding RNAs that participate in a variety of biologic processes, and dysregulation of miRNA is always associated with cancer development and progression. | 23171948 |
| Lupus Erythematosus, Autoimmune Diseases, Rheumatoid Arthritis, MS gene | Epigenetic Alterations | MicroRNA expression profiles have been identified in several autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. | 23173724 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Reduced expression of microRNA-100 confers unfavorable prognosis in patients with bladder cancer. | 23173870 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA-100 (miR-100) has been demonstrated to be downregulated in bladder cancer tissues, and enforced expression of this miRNA may inhibit cell growth and colony formation of human bladder cancer 5637 cells in vitro. | 23173870 |
| Malignant neoplasm of urinary bladder, Primary malignant neoplasm | Epigenetic Alterations | Our data offer the convincing evidence that miR-100 may play an important role in the progression of bladder cancer and that the reduced expression of this miRNA may be independently associated with shorter PFS and OS of patients, suggesting that miR-100 might be a potential marker for further risk stratification in the treatment of this cancer. | 23173870 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Plasma specific miRNAs as predictive biomarkers for diagnosis and prognosis of glioma. | 23174013 |
| Malignant Neoplasms | Epigenetic Alterations | Recently, some researchers have demonstrated that plasma miRNAs are sensitive and specific biomarkers of various cancers. | 23174013 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | These findings suggest that plasma specific miRNAs have potential use as novel biomarkers of glioma and may be useful in clinical management for glioma patients. | 23174013 |
| Pancreatic carcinoma | Epigenetic Alterations | To explore the clinical significance of miRNA-216a expression in pancreatic cancer. | 23174591 |
| Pancreatic carcinoma | Epigenetic Alterations | The expression of miRNA-216a was significantly lower in pancreatic cancer than in benign pancreas lesions (P=0.000). | 23174591 |
| Neoplasms | Epigenetic Alterations | It has been suggested that SMARCB1 may be silenced by epigenetic changes in the remaining 90% of tumors. | 23174932 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | microRNA and inflammatory gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma. | 23175214 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | These data were combined to generate a miRNA risk score that was significantly associated with worse prognosis (p = 0.0001), suggesting that these miRNAs may be useful prognostic classifiers for ESCC. | 23175214 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Therefore, miRNA and inflammatory gene expression patterns, alone or in combination, have potential as prognostic classifiers for ESCC and may help to guide therapeutic decisions. | 23175214 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | MicroRNAs (miRNAs) and inflammatory genes have a role in the initiation and development of esophageal squamous cell carcinoma (ESCC). | 23175214 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-27a inhibitors alone or in combination with perifosine suppress the growth of gastric cancer cells. | 23175237 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-27a (miR-27a) is an oncogene that contributes to drug resistance in various types of cancer. | 23175237 |
| Clinical Coordinator | Epigenetic Alterations | We carried out comprehensive genome-scale DNA methylation profiling by Illumina Infinium HumanMethylation27 of 21 DNA pools that represent 84 CRC samples divided according to their high-, intermediate-, and low-methylation epigenotypes (HME, IME, and LME, respectively) and 70 normal-adjacent colonic tissues. | 23175427 |
| Primary malignant neoplasm, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Tumor-suppressive microRNA-135a inhibits cancer cell proliferation by targeting the c-MYC oncogene in renal cell carcinoma. | 23176581 |
| Malignant Neoplasms, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Recently, many studies have suggested that microRNAs (miRNAs) are involved in cancer cell development, invasion, and metastasis of various types of human cancers. | 23176581 |
| AMD1 wt Allele | Epigenetic Alterations | Furthermore, we showed that hypomethylation of the IL17RC promoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RC may potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis. | 23177625 |
| Non-Malignant | Epigenetic Alterations | All miRNAs were suitable to discriminate malignant from non-malignant tissue. | 23178446 |
| Impaired, Right arm | Epigenetic Alterations | The impaired apoptosis in RA synovium might result from increased autophagy, which in turn could be due to the deregulation of miRNA-30a. | 23178792 |
| estrogen receptor-positive breast cancer, Neoplasms | Epigenetic Alterations | In this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissue were compared between ER(high) Ki67(low) tumors and ER(low) Ki67(high) tumors by miRNA and mRNA microarrays. | 23183268 |
| Neoplasms | Epigenetic Alterations | We picked up 11 genes that were potential target genes of the selected miRNAs and that were differentially expressed in ER(high) Ki67(low) tumors and ER(low) Ki67(high) tumors. | 23183268 |
| Fibrosis Assessment | Epigenetic Alterations | miRNAs are novel regulators of organ fibrosis. | 23183523 |
| Primary malignant neoplasm | Epigenetic Alterations | Expression of miRNA associated with Gleason grading system may contribute to more accurate preoperative cancer risk evaluation. | 23184537 |
| Prostate Cancer Pathway | Epigenetic Alterations | Expression of microRNAs associated with Gleason grading system in prostate cancer: miR-182-5p is a useful marker for high grade prostate cancer. | 23184537 |
| Prostate Cancer Pathway | Epigenetic Alterations | Expression profiles of some microRNAs (miRNAs) were associated with clinicopathological findings in human prostate cancer (PC), but the relative expression of miRNAs among Gleason patterns (GPs) remains unclear. | 23184537 |
| Breast Carcinoma | Epigenetic Alterations | Furthermore miRNA-24 expression levels in breast cancer patient specimens showed no correlation with TRIB3 mRNA or TRIB3 protein levels, or with prognosis. | 23185332 |
| Breast Carcinoma | Epigenetic Alterations | Thus, the expression of miRNA-24 does not explain the difference between mRNA and protein expression of TRIB3 in this cohort of breast cancer patients. | 23185332 |
| Autoimmune hepatitis, Primary Biliary Cholangitis | Epigenetic Alterations | Epigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis. | 23187010 |
| Autoimmune liver disease | Epigenetic Alterations | Epigenetic changes are of crucial importance in the etiopathogenesis of autoimmune liver diseases. | 23187010 |
| Cerebral Hemorrhage, Hypertrophy | Epigenetic Alterations | Circulating MicroRNAs as potential risk biomarkers for hematoma enlargement after intracerebral hemorrhage. | 23190933 |
| Cerebral Hemorrhage | Epigenetic Alterations | MicroRNAs have recently been shown to regulate the downstream bioprocesses of intracerebral hemorrhage. | 23190933 |
| helium, Infectious Canine Hepatitis | Epigenetic Alterations | We demonstrated that multiple miRNAs are differentially expressed in the plasma of ICH patients with or without HE and may serve as circulating biomarkers for predicting HE after ICH. | 23190933 |
| Autoimmune Diseases, Myasthenia Gravis | Epigenetic Alterations | Myasthenia gravis (MG) are T-cell dependent antibody-mediated autoimmune disorders, microRNAs are important regulators of human autoimmune disease pathogenesis. | 23196978 |
| Neoplasms | Epigenetic Alterations | This is the first report describing microRNA-mediated down-regulation of ATM leading to clinically manifest tumor radiosensitivity. | 23199656 |
| Primary malignant neoplasm | Epigenetic Alterations | Our results indicate that epigenetic silencing of miRNA genes may be involved in the development of BCa and that methylation of miRNA genes could be a useful biomarker for cancer detection. | 23200812 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Methylation of a panel of microRNA genes is a novel biomarker for detection of bladder cancer. | 23200812 |
| Primary Neoplasm, Primary malignant neoplasm | Epigenetic Alterations | Bisulfite pyrosequencing was used to assess miRNA gene methylation in 5 cancer cell lines, 83 primary tumors, and 120 preoperative and 47 postoperative urine samples. | 23200812 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Dysregulation of microRNAs (miRNAs) has been implicated in bladder cancer (BCa), although the mechanism is not fully understood. | 23200812 |
| Cerebrovascular accident | Epigenetic Alterations | The combined effects between microRNA polymorphisms and homocysteine/folate levels may contribute to stroke and SBI prevalence. | 23202363 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Decreased expression of microRNA-375 in nonsmall cell lung cancer and its clinical significance. | 23206448 |
| Malignant Neoplasms | Epigenetic Alterations | Emerging evidence has shown the association of aberrant microRNA-375 (miR-375) expression with tumourigenesis in many types of human malignancy. | 23206448 |
| ovarian neoplasm | Epigenetic Alterations | Epigenetic and immunohistochemical characterization of the Clusterin gene in ovarian tumors. | 23208459 |
| Malignant Ovarian Cyst, Serous cystadenoma, borderline malignancy | Epigenetic Alterations | To characterize abnormal epigenetic changes and protein expression of the clusterin gene in a large series of ovarian malignant and borderline tumors. | 23208459 |
| Malignant Neoplasms | Epigenetic Alterations | microRNAs (miRNAs) are small non-coding RNAs that can function as endogenous silencers of target genes and play critical roles in human malignancies. | 23209550 |
| Gastric Mucosa-Associated Lymphoid Tissue Lymphoma | Epigenetic Alterations | These miRNAs might have potential application as therapeutic targets and novel biomarkers for gastric MALT lymphoma. | 23209550 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer. | 23209692 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We employed a genome-scale marker discovery method to identify and verify candidate DNA methylation biomarkers for blood-based detection of colorectal cancer. | 23209692 |
| Stomach Carcinoma | Epigenetic Alterations | Determination of plasma microRNA for early detection of gastric cancer. | 23212612 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | We demonstrated that miR-195-5p is a novel tumor suppressor miRNA and may contribute to gastric carcinogenesis. | 23212612 |
| Liver carcinoma | Epigenetic Alterations | Frequent concomitant epigenetic silencing of SOX1 and secreted frizzled-related proteins (SFRPs) in human hepatocellular carcinoma. | 23215838 |
| Malignant Neoplasms | Epigenetic Alterations | Except for genetic mutations, epigenetic changes are also involved in the development of human cancers. | 23215838 |
| Neoplasms | Epigenetic Alterations | Our findings indicate pre-miRNA polymorphisms may predict tumor HPV16-positive SCCOP cases and may be prognostic biomarkers for SCCOP. | 23219900 |
| Diabetic Retinopathy | Epigenetic Alterations | Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: role of histone methylation. | 23221071 |
| Diabetic Retinopathy | Epigenetic Alterations | Histone methylation of retinal Sod2 has an important role in the development of diabetic retinopathy and in the metabolic memory phenomenon associated with its continued progression. | 23221071 |
| Diabetic Retinopathy | Epigenetic Alterations | Targeting enzymes important for histone methylation may serve as a potential therapy to halt the development of diabetic retinopathy. | 23221071 |
| melanoma | Epigenetic Alterations | The rs2910164 G>C polymorphism in microRNA-146a is associated with the incidence of malignant melanoma. | 23222547 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-146a (miR-146a) is one of the microRNAs (miRNAs) implicated in the pathogenesis of various cancers. | 23222547 |
| Adenocarcinoma, Carcinoma, Neuroendocrine | Epigenetic Alterations | Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum. | 23224118 |
| Colorectal Carcinoma | Epigenetic Alterations | Methylation-specific multiple ligation-dependent probe amplification (MS-MLPA) is a fast, new, inexpensive method that has rarely been exploited in DNA methylation profiling of colorectal cancers (CRCs). | 23224118 |
| Neoplasms | Epigenetic Alterations | MS-MLPA assay is an easy and reliable system for epigenetic characterization of tumor tissues and leads to a rapid identification of CRCs with the highest levels of gene methylation. | 23224118 |
| Breast Carcinoma | Epigenetic Alterations | The microRNA maturation regulator Drosha is an independent predictor of outcome in breast cancer patients. | 23225145 |
| Neoplasms | Epigenetic Alterations | These observations provide further evidence that alterations in miRNA regulation influence tumour behaviour. | 23225145 |
| Breast Carcinoma | Epigenetic Alterations | Drosha is a protein that plays a key role in the biogenesis of microRNAs which are well known to be deranged in human breast cancer (BC). | 23225145 |
| Asthma Pathway | Epigenetic Alterations | The results of the current study provide evidence for differential function of T cell subsets in monozygotic twins discordant for asthma that are regulated by changes in DNA methylation. | 23226205 |
| Asthma Pathway | Epigenetic Alterations | T cells mediate the inflammatory responses observed in asthma among genetically susceptible individuals and have been suspected to be prone to epigenetic regulation. | 23226205 |
| Human Papillomavirus-Related Cervical Carcinoma, Neoplasms | Epigenetic Alterations | Changes in host tumor genome DNA methylation patterns are among the molecular alterations associated with HPV-related carcinogenesis. | 23226306 |
| Anal squamous cell carcinoma | Epigenetic Alterations | However, there is little known about the epigenetic changes associated specifically with the development of anal squamous cell cancer (SCC). | 23226306 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Increased expression of microRNA-17 predicts poor prognosis in human glioma. | 23226946 |
| Breast Carcinoma | Epigenetic Alterations | An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma. | 23227519 |
| Breast Carcinoma | Epigenetic Alterations | Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer. | 23228090 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Emerging evidence has shown that miRNAs are involved in human carcinogenesis as tumor suppressors or oncogenes. | 23228090 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | To gather more knowledge on microRNAs in human hepatocellular carcinoma (HCC) we generated a small RNA library in the human HCC cell line HA22T/VGH by cloning and sequencing the cDNA obtained following the size selection of 18-24 nucleotide RNAs. | 23229173 |
| Hollings Cancer Center | Epigenetic Alterations | We determined the expression levels of the most frequently cloned microRNAs by qPCR in HCC tissues and in their peritumoral counterparts from biopsy specimens of 41 HCC patients. | 23229173 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC. | 23229173 |
| Carcinogenesis | Epigenetic Alterations | Polymorphisms in 3 untranslated region (UTR) of cancer-related genes might affect their regulation by microRNAs (miRNAs) and thereby contribute to carcinogenesis. | 23232114 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Further investigations may also help to elucidate the biological role of microRNA-200c in DLBCL. | 23232598 |
| Breast Carcinoma, NRAS gene | Epigenetic Alterations | miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1. | 23233531 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are a class of small noncoding RNAs whose expression changes are associated with cancer development and invasion. | 23238818 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | The level of circulating miRNA-10b and miRNA-373 in detecting lymph node metastasis of breast cancer: potential biomarkers. | 23238818 |
| Breast Carcinoma | Epigenetic Alterations | Our data suggest that circulating miRNA-10b and miRNA-373 are potential biomarkers for detecting the lymph node status of breast cancer. | 23238818 |
| Breast Carcinoma | Epigenetic Alterations | A miRNA binding site single-nucleotide polymorphism in the 3-UTR region of the IL23R gene is associated with breast cancer. | 23239971 |
| Breast Carcinoma | Epigenetic Alterations | Our results suggest that a miRNA binding site SNP in the 3-UTR region of the IL23R gene may be associated with the risk of breast cancer and contribute to the early development of breast cancer in Chinese women. | 23239971 |
| Neoplasms | Epigenetic Alterations | To date, most epigenetic studies have focused on somatic methylation events occurring within solid tumors; less is known of the contributions of peripheral blood cell (PBC) methylation to processes such as aging and tumorigenesis. | 23240038 |
| Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA-27a (miR-27a) is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10. | 23240057 |
| Inflammation | Epigenetic Alterations | Epigenetic modification, oxidative stress, and inflammation play an important role in the pathogenesis of the disease. | 23242124 |
| Diastolic dysfunction | Epigenetic Alterations | Circulating miRNA as novel markers for diastolic dysfunction. | 23247724 |
| Cardiovascular Diseases | Epigenetic Alterations | The diagnostic potential of miRNA detection in human plasma for cardiovascular disorders is beginning to be recognized as important. | 23247724 |
| Dilated Cardiomyopathy Pathway, Diastolic dysfunction, Congestive heart failure | Epigenetic Alterations | The presence of these miRNAs was tested in stable patients with isolated DD, patients with stable compensated dilated cardiomyopathy (DCM-systolic plus diastolic dysfunction) and those with decompensated congestive heart failure secondary to dilated cardiomyopathy (DCM-CHF-systolic plus diastolic dysfunction). | 23247724 |
| Diastolic dysfunction | Epigenetic Alterations | We identified new circulating miRNAs (miR-454, miR-500, miR-1246, miR-142-3p) which showed distinct patterns of expression in patients with diastolic dysfunction. | 23247724 |
| Diastolic dysfunction | Epigenetic Alterations | We therefore propose that these circulating miRNAs may serve as novel biomarkers for diastolic dysfunction because in all of these patients the only common factor was diastolic dysfunction. | 23247724 |
| Breast Carcinoma | Epigenetic Alterations | In addition, identifying patients with KEAP1 epigenetic abnormalities may contribute to disease progression prediction in breast cancer patients. | 23249627 |
| Fibrosis Assessment | Epigenetic Alterations | Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis. | 23250779 |
| Inflammation | Epigenetic Alterations | The hypermethylation of E-cadherin and cyclooxygenase 2 (COX-2) in chronic inflammation may demonstrate a mild lesion/mutation at epigenetic levels. | 23250779 |
| Inflammation, Primary malignant neoplasm | Epigenetic Alterations | The epigenetic changes presented in patients with chronic inflammation might demonstrate an irreversible destruction in the tissues or organs similar to the effects of cancer. | 23250779 |
| Diabetes Mellitus | Epigenetic Alterations | Furthermore, exposure of healthy CD34(pos)-PCs to high glucose reproduced the transcriptional changes induced by diabetes mellitus, with this effect being reversed by forced expression of microRNA-155. | 23250986 |
| Allergic sensitization | Epigenetic Alterations | Allergen sensitization is associated with increased DNA methylation in older men. | 23257623 |
| Asthma Pathway, Allergic sensitization | Epigenetic Alterations | These data suggest that increased DNA methylation of repetitive elements may be associated with allergen sensitization but does not appear to be associated with asthma. | 23257623 |
| Hypersensitivity, Asthma Pathway | Epigenetic Alterations | Variation in epigenetic modifications, arising from either environmental exposures or internal physiological changes, can influence gene expression and may ultimately contribute to complex diseases such as asthma and allergies. | 23257623 |
| Asthma Pathway | Epigenetic Alterations | Previous studies have suggested that the pathogenesis of asthma may be affected by epigenetic regulation. | 23257708 |
| Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma | Epigenetic Alterations | Micro-RNA-16 expression in paraffin-embedded specimen correlates with overall survival of T-lymphoblastic lymphoma/leukemia. | 23260326 |
| Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma | Epigenetic Alterations | To our knowledge, we provide here the first evidence that the expression of a single micro-RNA, miR-16, is associated with clinical outcome of patients with T-lymphoblastic lymphoma/leukemia. | 23260326 |
| Neoplasms | Epigenetic Alterations | Recently, specific micro-RNAs have emerged as potential biomarkers for the diagnosis and prognosis of various types of tumor. | 23260326 |
| Epilepsy, Temporal Lobe | Epigenetic Alterations | Recently, several miRNAs have been found to be differentially expressed in animal models of TLE. | 23262343 |
| Thrombocytosis, Polycythemia Vera | Epigenetic Alterations | MicroRNA deregulation in polycythemia vera and essential thrombocythemia patients. | 23265742 |
| Erythrocytosis | Epigenetic Alterations | Since erythrocytosis is the only feature that distinguishes PV from ET, we also compared specific miRNA expression in the nucleated erythroid cells directly descended from the early erythroid progenitor cells of PV and ET patients. | 23265742 |
| Erythrocytosis, Thrombocytosis | Epigenetic Alterations | The results of our study also suggest that deregulated miRNAs may represent an important mechanism by which the PV erythrocytosis and ET thrombocytosis phenotypes are determined. | 23265742 |
| Primary malignant neoplasm | Epigenetic Alterations | The miRNA-regulating enzymes Dicer and Drosha exhibit aberrant expression in several cancer types. | 23266047 |
| Prostate Cancer Pathway | Epigenetic Alterations | Development and clinical validation of a real-time PCR assay for PITX2 DNA methylation to predict prostate-specific antigen recurrence in prostate cancer patients following radical prostatectomy. | 23266319 |
| Prostate Cancer Pathway | Epigenetic Alterations | PITX2 DNA methylation is a strong prognostic biomarker in prostate cancer. | 23266319 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Circulating microRNAs in serum: novel biomarkers for patients with bladder cancer? | 23266581 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) such as miR-17-5p, miR-21, miR-106a and miR-106b are reported to be highly expressed in gastric carcinoma (GC) tissues. | 23267156 |
| Neoplasms | Epigenetic Alterations | Recently, we reported that these miRNAs were consistently detectable in plasma and reflected tumor dynamics of GC. | 23267156 |
| Clinical Coordinator | Epigenetic Alterations | Patients with CRC or AAs had plasma miRNA expression profiles that differed significantly from those of controls. | 23267864 |
| Clinical Coordinator | Epigenetic Alterations | Patients with CRC have significantly different patterns of miRNA expression than healthy individuals. | 23267864 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNAs (miRNAs/miRs) might be used as biomarkers for the diagnosis of cancer and other diseases. | 23267864 |
| Clinical Coordinator | Epigenetic Alterations | We selected a group of 13 miRNAs for validation in an independent cohort of patients; 6 (miR18a, miR19a, miR19b, miR15b, miR29a, and miR335) were confirmed to be significantly up-regulated in patients with CRC, differentiating patients with CRC from controls with area under the receiver operating characteristic curve values ranging from 0.80 (95% confidence interval [CI], 0.71-0.89) to 0.70 (95% CI, 0.59-0.80). | 23267864 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Different patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer. | 23271133 |
| Neoplasms | Epigenetic Alterations | These findings suggest that miR-149 suppresses tumor cell mobility, and that the pre-mir-149 polymorphism may affect the processing of miR-149, resulting in a change in the abundance of the mature form miRNA, which, in turn, modulates tumor progression and patient survival. | 23272122 |
| Malignant Neoplasms, Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in modulating the neoplastic process of cancers including head and neck squamous cell carcinoma (HNSCC). | 23272122 |
| Carcinoma, Ovarian Epithelial | Epigenetic Alterations | Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer. | 23272653 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs are stable in the circulation and may have utility as biomarkers of malignancy. | 23272653 |
| Tuberculosis, Pulmonary | Epigenetic Alterations | Altered serum microRNAs as biomarkers for the early diagnosis of pulmonary tuberculosis infection. | 23272999 |
| Tuberculosis, Pulmonary | Epigenetic Alterations | The Low-Density Array data showed that 97 miRNAs were differentially expressed in pulmonary TB patient sera compared with healthy controls (90 up-regulated and 7 down-regulated). | 23272999 |
| Lymphoma, Follicular | Epigenetic Alterations | Prognostic significance of epigenetic inactivation of p16, p15, MGMT and DAPK genes in follicular lymphoma. | 23275143 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Further research is warranted on the SWI/SNF complex genes and epigenetic mechanisms more generally in the development of glioma in adults. | 23276717 |
| Clinical Coordinator | Epigenetic Alterations | A significant association with increased disease free survival was confirmed for miR-362-3p in a second independent cohort of 43 CRC patients, using single TaqMan((r)) microRNA assays. | 23280316 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer. | 23280316 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are aberrantly expressed in cancers and appear to have both diagnostic and prognostic significance. | 23280316 |
| Neoplasms | Epigenetic Alterations | Four miRNAs (miR-362-3p, miR-570, miR-148 a* and miR-944) were expressed at a higher level in tumors from patients with no recurrence (p<0.015), compared with tumors from patients with recurrence. | 23280316 |
| Carcinoma | Epigenetic Alterations | Epigenetic changes in Basal Cell Carcinoma affect SHH and WNT signaling components. | 23284750 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Epigenetic alterations such as promoter hypermethylation silence tumor suppressor genes (TSG) in several malignancies. | 23284750 |
| Ulcerative Colitis | Epigenetic Alterations | Up-regulation of microRNA-126 may contribute to pathogenesis of ulcerative colitis via regulating NF-kappaB inhibitor IkBa. | 23285182 |
| Ulcerative Colitis | Epigenetic Alterations | Altered expression of miRNAs has recently demonstrated association with human ulcerative colitis (UC). | 23285182 |
| SERPINB3 wt Allele, Primary malignant neoplasm | Epigenetic Alterations | Although OSCC seems as much an epigenetic as a genetic disease, the translational potential of cancer epigenetics has yet to be fully exploited. | 23287992 |
| Squamous cell carcinoma | Epigenetic Alterations | The epigenetic landscape of oral squamous cell carcinoma. | 23287992 |
| SERPINB3 wt Allele | Epigenetic Alterations | Epigenetic deregulation of NOTCH4 signalling in OSCC was also observed, as part of a possible methylation signature for recurrence, with parallels to recently discovered NOTCH mutations in HNSCC. | 23287992 |
| SERPINB3 wt Allele | Epigenetic Alterations | This data points to the application of epigenetic biomarkers and targets available to further the development of therapy in OSCC. | 23287992 |
| Inflammatory Bowel Diseases | Epigenetic Alterations | Overexpression of microRNAs-155 and 21 targeting mismatch repair proteins in inflammatory bowel diseases. | 23288924 |
| ibudilast | Epigenetic Alterations | Here, we hypothesize that overexpression of miR-155 and miR-21, two inflammation-related microRNAs that target core MMR proteins, may constitute a pre-neoplastic event for the development of MSI IBD CRCs. | 23288924 |
| ibudilast, Primary malignant neoplasm | Epigenetic Alterations | These results show a strong deregulation of both MMR-targeting microRNAs in IBD subjects with or without cancer. | 23288924 |
| Stomach Carcinoma | Epigenetic Alterations | Loss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancer. | 23291975 |
| Stomach Carcinoma | Epigenetic Alterations | Bisulfate sequencing showed that TFF1 expression is strongly dependent on DNA methylation in both gastric cancer cells and tissues. | 23291975 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | TFF1 expression is silenced by DNA methylation and is associated with tumor invasion and a poor survival in gastric cancer patients. | 23291975 |
| Helicobacter Pylori-Related Gastric Adenocarcinoma | Epigenetic Alterations | Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis. | 23292007 |
| Carcinogenesis, Helicobacter pylori, Inflammation | Epigenetic Alterations | Chronic inflammation triggered by Helicobacter pylori causes altered DNA methylation in stomach mucosae, which is deeply involved in gastric carcinogenesis. | 23292007 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Aberrant expression as well as genetic and epigenetic alterations of numerous genes involved in different pathways of apoptosis regulation has been described in CLL. | 23292833 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Expression and clinical significance of microRNA-326 in human glioma miR-326 expression in glioma. | 23292865 |
| Neoplasms | Epigenetic Alterations | As a suppressor of Hedgehog signaling pathway, microRNA-326 (miR-326) has been demonstrated to control the development of cerebellar neuronal progenitor and tumor cells. | 23292865 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Correlation of microRNA-372 upregulation with poor prognosis in human glioma. | 23298385 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-372 (miR-372) acts as either an oncogenic miRNA or an anti-oncomiR in various human malignancies. | 23298385 |
| Malignant Neoplasms, Glioma, Neoplasms | Epigenetic Alterations | Taken together, these data offer the convincing evidence for the first time that miR-372 may act as an oncogenic miRNA in gliomas and represent a potential regulator of aggressive development and a candidate prognostic marker for this malignancy, especially for advanced tumors with high pathological grades. | 23298385 |
| Hollings Cancer Center | Epigenetic Alterations | Our data suggest potential molecular mechanisms underpinning miRNA-controlled HCC recurrence, and support the notion that miRNA expression signature and miRNA-based therapy can be useful tools for a better diagnosis and treatment stratification of this disease. | 23299437 |
| Liver carcinoma | Epigenetic Alterations | Identification of recurrence related microRNAs in hepatocellular carcinoma after surgical resection. | 23299437 |
| Primary malignant neoplasm, Hollings Cancer Center | Epigenetic Alterations | Moreover, functional annotation of predicted target genes of these recurrent HCC-related miRNAs indicates that multiple biological pathways (i.e., focal adhesion pathway, cancer-related pathways and mitogen-activated protein kinase (MAPK) signaling) that are all critical for cancer development and progression, may participate in the recurrence of HCC. | 23299437 |
| Primary malignant neoplasm | Epigenetic Alterations | Cancer subjects had significantly lower PBMCs-DNA methylation than controls [4.39 (95% confidence intervals (CI), 4.25-4.53) vs. 5.13 (95% CI, 5.03-5.21) %mCyt/(mCyt+Cyt); P < 0.0001]. | 23300023 |
| Primary malignant neoplasm | Epigenetic Alterations | A DNA methylation threshold of 4.74% clearly categorized patients with cancer from controls so that those with DNA methylation less than 4.74% showed an increased prevalence of cancer than those with higher levels (91.5% vs. 19%; P < 0.001). | 23300023 |
| Primary malignant neoplasm | Epigenetic Alterations | Subjects with cancer at follow-up had, already at enrollment, reduced DNA methylation as compared with controls [4.34 (95% CI, 4.24-4.51) vs. 5.08 (95% CI, 5.05-5.22) %mCyt/(mCyt+Cyt); P < 0.0001]. | 23300023 |
| Primary malignant neoplasm | Epigenetic Alterations | Moreover, MTHFR677C>T genotype and folate interact for determining DNA methylation, so that MTHFR677TT carriers with low folate had the lowest DNA methylation and concordantly showed a higher prevalence of cancer history (OR, 7.04; 95% CI, 1.52-32.63; P = 0.013). | 23300023 |
| Primary malignant neoplasm | Epigenetic Alterations | Genomic PBMCs-DNA methylation may be a useful epigenetic biomarker for early detection and cancer risk estimation. | 23300023 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome. | 23300180 |
| Antilymphocyte Serum | Epigenetic Alterations | Alterations in epigenetic modifications are likely to play a role in disease onset and progression in ALS, as aberrant epigenetic patterns may be acquired throughout life. | 23300739 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Profiling results showed 8 miRNAs were concordantly up-regulated and 1 miRNA was concordantly down-regulated in both plasma and tumor tissue of breast cancer patients. | 23301032 |
| Breast Carcinoma | Epigenetic Alterations | Circulating microRNAs as specific biomarkers for breast cancer detection. | 23301032 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We previously showed microRNAs (miRNAs) in plasma are potential biomarkers for colorectal cancer detection. | 23301032 |
| Breast Carcinoma | Epigenetic Alterations | These results suggested that these circulating miRNAs could be a potential specific biomarker for breast cancer screening. | 23301032 |
| Congestive heart failure | Epigenetic Alterations | MicroRNA 210 as a biomarker for congestive heart failure. | 23302636 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) play crucial roles during the occurrence and development of gastric cancer. | 23307240 |
| Stomach Carcinoma | Epigenetic Alterations | Several miRNAs in peripheral blood have been used as biomarkers of gastric cancer. | 23307240 |
| Primary malignant neoplasm | Epigenetic Alterations | However, most of these miRNAs are shared by several types of cancer. | 23307240 |
| Stomach Carcinoma | Epigenetic Alterations | In summary, our results suggest that gastric juice miR-129-1-3p and miR-129-2-3p are potential biomarkers for the screening gastric cancer, and the detection of gastric juice miRNAs is a convenient non-invasion method for the diagnosis of gastric cancer. | 23307240 |
| Impaired cognition, Fetal Measurements Domain | Epigenetic Alterations | Methylation of the fragile X-related epigenetic element 2 (FREE2) located on the exon 1/intron 1 boundary of the FMR1 gene is related to FMRP expression and cognitive impairment in full mutation (FM; CGG>200) individuals. | 23307923 |
| Behavior | Epigenetic Alterations | MicroRNAs (miRNAs) regulate cancer cell behavior and may be attractive biomarkers for prognosis and prediction of response. | 23308047 |
| Fibrosis Assessment | Epigenetic Alterations | MicroRNA signature at the time of clinical HCV recurrence associates with aggressive fibrosis progression post-liver transplantation. | 23312020 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm. | 23316282 |
| Arteriosclerosis, Coronary Arteriosclerosis | Epigenetic Alterations | MicroRNAs play a fundamental role in atherosclerosis, and atherosclerotic coronary artery disease is characterized by tissue- and plasma-specific microRNA signatures. | 23316282 |
| SF3B1 wt Allele, Myeloid neoplasm, Myeloproliferative disease, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Genomic studies in chronic myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and MPN/MDS, have identified common mutations in genes encoding signaling, epigenetic, transcription, and splicing factors. | 23319568 |
| Osteosarcoma | Epigenetic Alterations | Identification of serum microRNA-21 as a biomarker for chemosensitivity and prognosis in human osteosarcoma. | 23321165 |
| Secondary malignant neoplasm of female breast | Epigenetic Alterations | MicroRNA-374a activates Wnt/b-catenin signaling to promote breast cancer metastasis. | 23321667 |
| Breast Carcinoma | Epigenetic Alterations | Here we report that Wnt/b-catenin signaling is hyperactivated in metastatic breast cancer cells that express microRNA 374a (miR-374a). | 23321667 |
| Cocarcinogenesis | Epigenetic Alterations | MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis. | 23322197 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA, miR)-18a is a member of the miR-17-92 cluster, an important locus that is markedly overexpressed in several cancers and associated with cancer development and progression. | 23322197 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | MicroRNA-34a promotes cardiomyocyte apoptosis post myocardial infarction through down-regulating aldehyde dehydrogenase 2. | 23323620 |
| Primary malignant neoplasm | Epigenetic Alterations | Gene silencing through CpG island hypermethylation is a major epigenetic mechanism involved in cancer development. | 23324576 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Our results suggest that epigenetic down-regulation of TMEM25 is cancer-related; we thus suggest that TMEM25 hypermethylation might play a significant role in altering expression of this gene in colorectal cancer. | 23324576 |
| Hypertensive disease, Hypertensive (finding) | Epigenetic Alterations | The identification of a difference in a blood leukocyte DNA methylation site between hypertensive cases and normotensive controls suggests that changes in DNA methylation may play an important role in the pathogenesis of hypertension. | 23325143 |
| Stomach Carcinoma | Epigenetic Alterations | Six of them were randomly selected and miRNA microarray was applied to study the miRNA expression profiles of gastric cancer. | 23328512 |
| Stomach Carcinoma | Epigenetic Alterations | Compared with normal gastric tissues, 7 miRNA were significantly up-regulated and 9 miRNA significantly down-regulated for over 2 folds in gastric cancer tissues (P < 0.05). | 23328512 |
| Stomach Carcinoma | Epigenetic Alterations | Special miRNA expression profiles of gastric cancer are found. | 23328512 |
| Intestinal Neuroendocrine Tumor | Epigenetic Alterations | Global microRNA profiling of well-differentiated small intestinal neuroendocrine tumors. | 23328977 |
| Neoplasms | Epigenetic Alterations | Moreover, we characterized nine miRNAs, five (miR-96, -182, -183, -196a and -200a), which are upregulated during tumor progression, whereas four (miR-31, -129-5p, -133a and -215) are downregulated. | 23328977 |
| Pancreatic carcinoma | Epigenetic Alterations | Up-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherin. | 23331011 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate gene expression, thereby affecting crucial processes in cancer development. | 23334650 |
| Breast Carcinoma | Epigenetic Alterations | Serum circulating microRNA profiling for identification of potential breast cancer biomarkers. | 23334650 |
| Breast Carcinoma | Epigenetic Alterations | We performed miRNA profiling on serum from breast cancer patients, followed by construction of ROC (Receiver Operating Characteristic) curves to determine the sensitivity and specificity of the assay. | 23334650 |
| Breast Carcinoma | Epigenetic Alterations | miRNA profiling in serum has potential as a novel method for breast cancer detection in the Mexican population. | 23334650 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNAs offer great potential as biomarkers for cancer detection because of their remarkable stability in blood and their characteristic expression in different diseases. | 23334650 |
| Breast Carcinoma | Epigenetic Alterations | We found that seven miRNAs (miR-10b, miR-21, miR-125b, miR-145, miR-155 miR-191 and miR-382) had different expression patterns in serum of breast cancer patients compared to healthy controls. | 23334650 |
| Admitting diagnosis | Epigenetic Alterations | Recent studies suggest epigenetic influences on gene expression in AD, as DNA methylation levels influence protein and mRNA expression in postmortem AD brain. | 23336521 |
| Arteriosclerosis | Epigenetic Alterations | Recent evidence supports a role for miRNAs in cardiovascular pathophysiology and atherosclerosis development. | 23339529 |
| Dilated Cardiomyopathy Pathway | Epigenetic Alterations | Alterations in cardiac DNA methylation in human dilated cardiomyopathy. | 23341106 |
| methylene chloride | Epigenetic Alterations | Aberrant DNA methylation in DCM patients was associated with significant changes in LY75 and ADORA2A mRNA expression, but not in ERBB3 and HOXB13. | 23341106 |
| methylene chloride | Epigenetic Alterations | Hence, disease mechanisms must exist that modify the occurrence and progression of DCM, either by genetic or epigenetic factors that may interact with environmental stimuli. | 23341106 |
| Adenocarcinoma | Epigenetic Alterations | Furthermore, we identified a three-miRNA plasma signature (high miR-155-5p, high miR-223-3p, and low miR-126-3p) that significantly associated with a higher risk for progression in adenocarcinoma patients. | 23342174 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In conclusion, we identified two plasma miRNA expression profiles that may be useful for predicting the outcome of patients with resectable NSCLC. | 23342174 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs), a group of small, noncoding RNAs, can be isolated from blood serum samples and have demonstrated utility as biomarkers in multiple cancer types. | 23342275 |
| Primary malignant neoplasm | Epigenetic Alterations | Combining these serum miRNA profiles with other screening techniques could greatly improve the sensitivity in oral cancer detection. | 23342275 |
| Malignant neoplasm of mouth | Epigenetic Alterations | Five of these miRNAs (miR-16, let-7b, miR-338-3p, miR-223, and miR-29a) yielded an area under the ROC curve (AUC) >0.8, suggesting utility as noninvasive biomarkers for detection of oral cancer or high-grade lesions. | 23342275 |
| Neoplasms | Epigenetic Alterations | In general, the overall tumor miRNA expression was downregulated in our cohort compared with normal tissues. | 23349018 |
| Squamous cell carcinoma, Adenocarcinoma | Epigenetic Alterations | Expression levels of hsa-let-7a (P = 0.005) and miR-16 (P = 0.003) miRNA were significantly higher in squamous cell carcinoma than in adenocarcinoma samples. | 23349018 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification. | 23349018 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Levels of DICER1, DROSHA and five different miRNAs were measured in NSCLC specimens (N = 115) by qRT-PCR assay and correlated with clinical outcomes. | 23349018 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In addition, differential expression of miRNAs, such as hsa-let-7a and miR-16 may be helpful tools in the histologic subclassification of NSCLC. | 23349018 |
| Meningioma | Epigenetic Alterations | DNA methylation in the malignant transformation of meningiomas. | 23349797 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Clustering analysis readily separates malignant from atypical and benign tumors, implicating that DNA methylation patterns may serve as diagnostic biomarkers for malignancy. | 23349797 |
| Meningioma, Malignant Meningioma | Epigenetic Alterations | Most genes with hypermethylated CpG islands at promoters are suppressed in malignant and benign meningiomas, suggesting the switching of gene silencing machinery from PRC binding to DNA methylation in malignant meningiomas. | 23349797 |
| S100A4 protein, human, Malignant Meningioma | Epigenetic Alterations | In summary, our results suggest that malignant meningiomas have distinct DNA methylation patterns compared to their benign and atypical counterparts, and that the differentially methylated genes may serve as diagnostic biomarkers or candidate causal genes for malignant transformation. | 23349797 |
| Meningioma, S100A4 protein, human, Malignant Meningioma | Epigenetic Alterations | Despite previous studies on benign and atypical meningiomas, the key molecular pathways involved in malignant transformation remain to be determined, as does the extent of epigenetic alteration in malignant meningiomas. | 23349797 |
| Malignant neoplasm of stomach | Epigenetic Alterations | miRCURY LNA Arrays (v.16.0; Exiqon, Vedbaek, Denmark) were used to screen miRNAs in 17 gastric cancers. | 23351547 |
| Stomach Carcinoma | Epigenetic Alterations | In gastric cancer, 49 miRNAs were overexpressed by 2.0-fold or greater, and 39 miRNAs were down-regulated by 1.5-fold or greater, whereas miR-10b was up-regulated by 2.98-fold. | 23351547 |
| Prostate Cancer Pathway, Obesity | Epigenetic Alterations | Recent evidence shows that certain microRNAs (miRNAs) play a role in both obesity and prostate cancer recurrence, but the association between the expression of these miRNAs and obesity in prostate cancer recurrence is unknown. | 23353719 |
| Malignant tumor of colon | Epigenetic Alterations | Clinical significance of microRNA-93 downregulation in human colon cancer. | 23354160 |
| Malignant tumor of colon | Epigenetic Alterations | MicroRNA-93 (miR-93) has been shown to suppress proliferation and colony formation of colon cancer stem cells. | 23354160 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating cell-free microRNAs (miRNAs) are potential cancer biomarkers. | 23354517 |
| Metastatic Neoplasm to the Bladder | Epigenetic Alterations | Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression. | 23354591 |
| Primary malignant neoplasm | Epigenetic Alterations | After adjusting for cancer site, stage, age, gender, alcohol consumption, and smoking status, HPV status was found to be a significant predictor for DNA methylation at an additional 11 genes, including CASP8 and SYBL1. | 23358896 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic changes are an important mechanism in carcinogenic progression, but how these changes differ between viral- and chemical-induced cancers remains unknown. | 23358896 |
| Carcinogenesis | Epigenetic Alterations | These findings provide insight into the epigenetic regulation of viral vs. chemical carcinogenesis and could provide novel targets for development of individualized therapeutic and prevention regimens based on environmental exposures. | 23358896 |
| Stage I Esophageal Squamous Cell Carcinoma AJCC v7 | Epigenetic Alterations | Serum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma. | 23361059 |
| Stage I Esophageal Squamous Cell Carcinoma AJCC v7, Squamous cell carcinoma of esophagus | Epigenetic Alterations | We performed an miRNA array using serum samples obtained from oesophageal squamous cell carcinoma (ESCC) patients or healthy controls. | 23361059 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | These data support our contention that serum miR-1246 has strong potential as a novel diagnostic and prognostic biomarker in ESCC, and its releasing mechanism is selective and independent of tissue miRNA abundance. | 23361059 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in blood and can serve as useful biomarkers for cancer. | 23361059 |
| Endometriosis | Epigenetic Alterations | We identified three distinct miRNA signatures with reliable differential expression between healthy individuals, patients with endometriosis, and patients with EAOC. | 23362326 |
| Endometriosis | Epigenetic Alterations | Our study reports for the first time that distinct plasma miRNA expression patterns may serve as highly specific and sensitive diagnostic biomarkers to discriminate between healthy, endometriosis, and EAOC cases. | 23362326 |
| Endometriosis, ovarian neoplasm | Epigenetic Alterations | Plasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer. | 23362326 |
| Endometriosis, ovarian neoplasm | Epigenetic Alterations | We aimed to identify plasma miRNAs that can be used to differentiate patients with endometriosis and ovarian cancer from healthy individuals. | 23362326 |
| Endometriosis | Epigenetic Alterations | In the first stage, using global profiling of more than 1,000 miRNAs via reverse transcriptase quantitative PCR (RT-qPCR) in a 20-patient initial screening cohort, we identified 23 candidate miRNAs, which are differentially expressed between healthy controls (n = 6), patients with endometriosis (n = 7), and patients with EAOC (n = 7) based on the fold changes. | 23362326 |
| Endometriosis, ovarian neoplasm | Epigenetic Alterations | In the second stage, the 23 miRNAs were further tested in an expanded cohort (n = 88) of healthy individuals (n = 20), endometriosis (n = 33), EAOC (n = 14), and serous ovarian cancer cases (SOC; n = 21, included as controls). | 23362326 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Agilent Human miRNA Microarray 16.0 was used to select the miRNAs on paraffin-embedded tissues of 24 DLBCL cases. | 23363792 |
| Bladder Neoplasm | Epigenetic Alterations | Bladder tumors in patients younger than 20 years show a low incidence of the genetic and epigenetic aberrations typically found in older patients. | 23369722 |
| Malignant Neoplasms | Epigenetic Alterations | One of the most common epigenetic aberrations in human malignancies is DNA hypermethylation. | 23369722 |
| Barrett Esophagus | Epigenetic Alterations | Discovery and validation of Barretts esophagus microRNA transcriptome by next generation sequencing. | 23372692 |
| Gastroesophageal reflux disease | Epigenetic Alterations | NGS-identified miRNA were validated using qRT-PCR in an independent group of 40 GERD and 27 BE patients. | 23372692 |
| Cluster | Epigenetic Alterations | Cluster analysis found similarly regulated (up or down) miRNA to share common targets suggesting coordination between miRNA. | 23372692 |
| Gastroesophageal reflux disease | Epigenetic Alterations | Differentially expressed miRNA between BE and GERD have been further validated. | 23372692 |
| Secondary malignant neoplasm of liver, Colorectal Neoplasms, Metastasis | Epigenetic Alterations | We compared miRNA expression between primary colorectal tumors and liver metastasis to identify those involved in the process of metastasis. | 23373973 |
| Secondary malignant neoplasm of liver, Primary Neoplasm | Epigenetic Alterations | The most abundant miRNA in liver metastasis compared with primary tumors was miR-122. | 23373973 |
| Malignant Neoplasms, Secondary malignant neoplasm of liver | Epigenetic Alterations | MicroRNAs have been shown to be involved in the development of many cancers, but little is known about their role in the process of colorectal liver metastasis. | 23373973 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Dysregulation of microRNA-100 (miR-100) has been reported to be involved in tumorigenesis and tumor progression of several cancer types. | 23378187 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Given the density of single-nucleotide polymorphisms (SNP) in the human genome and the sensitivity of single-nucleotide changes in microRNA (miRNA) functionality and processing, we asked whether polymorphisms within miRNA processing pathways and binding sites may influence non-small cell lung cancer (NSCLC) patients prognosis. | 23378343 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These results indicate that miRNA-related polymorphisms may be associated with NSCLC patients clinical outcomes through altered miRNA regulation of target genes. | 23378343 |
| Neoplasms | Epigenetic Alterations | MicroRNAs are small molecules involved in several cellular processes, and their expression is altered in the vast majority of tumors. | 23383149 |
| Liver damage, Hepatitis C, Chronic | Epigenetic Alterations | Sensitive detection of hepatocellular injury in chronic hepatitis C patients with circulating hepatocyte-derived microRNA-122. | 23383654 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Predicting progression of bladder urothelial carcinoma using microRNA expression. | 23387295 |
| Neoplasms | Epigenetic Alterations | For 19 samples, microdissection was performed to compare microRNA expression between the tumour and surrounding tissue. | 23387295 |
| Neoplasms | Epigenetic Alterations | The microRNA profile of tumours invading the bladder muscle was more similar to that of NMI tumours from patients who later progressed, than to that of the same-stage NMI tumours from patients who did not later progress. | 23387295 |
| Neoplasms | Epigenetic Alterations | The expression level of one microRNA, miR-29c*, was significantly under-expressed in tumours that progressed and could be used to stratify patients with T1 disease into risk groups. | 23387295 |
| Neoplasms | Epigenetic Alterations | Tumour progression was associated with altered levels of microRNAs. | 23387295 |
| NMI protein, human, Carcinoma of bladder | Epigenetic Alterations | To identify microRNAs that could be useful as prognostic markers for non-muscle-invasive (NMI) bladder carcinoma. | 23387295 |
| Neoplasms | Epigenetic Alterations | MicroRNAs that were found to be unrelated to the tumour itself were excluded as potential prognostic markers. | 23387295 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | MicroRNAs can be useful biomarkers for prognosis in patients with urothelial carcinoma. | 23387295 |
| Breast Carcinoma | Epigenetic Alterations | Down-regulation of miRNA-30a in human plasma is a novel marker for breast cancer. | 23389917 |
| Neoplasms | Epigenetic Alterations | And we compared the diagnostic value of plasma miRNA-30a with conventional circulating tumor markers CA153 and CEA. | 23389917 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | The status of ER and triple-negative BC was significantly associated with miRNA-30a level (P = 0.007 and P = 0.005, respectively). | 23389917 |
| Prostate Cancer Pathway, Malignant neoplasm of prostate | Epigenetic Alterations | Characterization of transcriptional changes in ERG rearrangement-positive prostate cancer identifies the regulation of metabolic sensors such as neuropeptide Y. ERG gene rearrangements are found in about one half of all prostate cancers. | 23390522 |
| Prostate Cancer Pathway | Epigenetic Alterations | Transcriptional changes between prostate cancer and non-cancerous prostate, as well as ERG rearrangement-positive (ERG+) and ERG rearrangement-negative (ERG-) prostate cancer, were analyzed. | 23390522 |
| Prostate Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | In summary, we found robust population-independent transcriptional changes in prostate cancer and first signs of ERG rearrangements inducing metabolic changes in cancer cells by activating major metabolic signaling molecules like NPY. | 23390522 |
| Malignant tumor of colon | Epigenetic Alterations | Functional polymorphism in the MicroRNA-367 binding site as a prognostic factor for colonic cancer. | 23393343 |
| Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | As microRNAs play important roles in cancer development and progression by regulating the expressions of oncogenes and tumor suppressor genes though interacting with the 3 untranslated region (UTR) of target genes, we aimed to evaluate the association between genetic variants of miRNAs and their binding sites and prognosis in patients with colorectal cancer (CRC). | 23393343 |
| Multiple Myeloma | Epigenetic Alterations | Impact of global and gene-specific DNA methylation pattern in relapsed multiple myeloma patients treated with bortezomib. | 23395385 |
| Neoplasms, Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-153 is tumor suppressive in glioblastoma stem cells. | 23397238 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Accumulating data indicate that some microRNAs (miRNAs or miRs) can function as tumor suppressors or oncogenes and as such are important in cancer development. | 23397547 |
| Liver carcinoma | Epigenetic Alterations | Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma. | 23398123 |
| Neoplasms | Epigenetic Alterations | Genetic alterations and deregulation of the miRNA biogenesis pathway components have been reported in human tumors. | 23398123 |
| Carcinogenesis | Epigenetic Alterations | Tissue-specific deletion of the Dicer gene, which encodes an essential miRNA processing enzyme, promotes carcinogenesis in animal models. | 23398123 |
| Primary malignant neoplasm | Epigenetic Alterations | These features indicate that aberrant miRNA biogenesis components are directly associated with cancer. | 23398123 |
| Hollings Cancer Center | Epigenetic Alterations | Trimethylation of histone H3 lysine 27 in the promoters is implicated in the deregulation of these miRNA-biogenesis-related genes in non-HBV genome integrated HCC cell lines. | 23398123 |
| Hollings Cancer Center | Epigenetic Alterations | In conclusion, deregulation of the miRNA biogenesis pathway components is frequently observed in non-viral-associated HCC and is linked to etiological risk factors and poor prognosis. | 23398123 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Long noncoding RNAs have been shown to have important regulatory roles in cancer biology, and long noncoding RNA 19 (H19) is essential for human tumor growth. | 23399020 |
| Ductal Carcinoma, Noninfiltrating Intraductal Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-132 is frequently down-regulated in ductal carcinoma in situ (DCIS) of breast and acts as a tumor suppressor by inhibiting cell proliferation. | 23399321 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Altered miRNA expression could also contribute to the origination of cancer, including breast cancer. | 23399321 |
| Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | Here, by using miRNA microarray and real time PCR, we analyzed the miRNA expression profile in 21 DCIS and the corresponding normal tissues. | 23399321 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | These findings highlight possible dysregulated pathways in SLE and suggest that circulating miRNA patterns distinguish SLE from other immunoinflammatory phenotypes. | 23401079 |
| Stomach Carcinoma | Epigenetic Alterations | Assessment of SOX17 DNA methylation in cell free DNA from patients with operable gastric cancer. | 23403728 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | DNA methylation represents one of the most common epigenetic changes in human cancer providing important information regarding carcinogenesis. | 23403728 |
| Hematologic Neoplasms | Epigenetic Alterations | Epigenetic inactivation of the MIR129-2 in hematological malignancies. | 23406679 |
| Neoplasms | Epigenetic Alterations | MIR129-2 has been shown to be a tumor suppressor microRNA hypermethylated in epithelial cancers. | 23406679 |
| Myeloid neoplasm, Neoplasms | Epigenetic Alterations | MIR129-2 is a tumor suppressive microRNA frequently methylated in lymphoid but not myeloid malignancies, leading to reversible MIR129-2 silencing. | 23406679 |
| Malignant neoplasm of urinary bladder, Aggressive behavior | Epigenetic Alterations | Decreased expression of microRNA-31 associates with aggressive tumor progression and poor prognosis in patients with bladder cancer. | 23408039 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-31 (miR-31) has different expression patterns in various human cancers. | 23408039 |
| Primary malignant neoplasm | Epigenetic Alterations | Leukocyte DNA methylation levels of selected imprinted genes may therefore serve as surrogate markers of DNA methylation in cancer tissue. | 23409079 |
| Primary malignant neoplasm | Epigenetic Alterations | There is growing interest in identifying surrogate tissues to identify epimutations in cancer patients since primary target tissues are often difficult to obtain. | 23409079 |
| Adenocarcinoma | Epigenetic Alterations | miRNA screening was done using qRT-PCR based low-density arrays (664 miRNAs) comparing adenocarcinoma patients (n=40) with and without recurrence 24 months after surgery. | 23410826 |
| Adenocarcinoma, Neoplasms | Epigenetic Alterations | Elevated miRNA levels were exclusively observed in the group of high-risk patient diagnosed for operable adenocarcinoma compared with benign diagnosis or advanced tumour disease. | 23410826 |
| Adenocarcinoma | Epigenetic Alterations | miRNAs were also measured in advanced adenocarcinoma patients (n=29), and individuals with benign pulmonary diagnosis (n=21). | 23410826 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Genome-wide profiling reveals epigenetic inactivation of the PU.1 pathway by histone H3 lysine 27 trimethylation in cytogenetically normal myelodysplastic syndrome. | 23411464 |
| Glioblastoma Multiforme | Epigenetic Alterations | Very little is known regarding correlation of micro RNA (miR)-106a with clinical outcomes of patients with glioblastoma multiforme (GBM). | 23416698 |
| Carcinogenesis, Thyroid Neoplasm | Epigenetic Alterations | Alterations in microRNA (miRNA) expression have been described in thyroid tumors, suggesting a role for miRNAs in thyroid carcinogenesis. | 23416953 |
| Papillary thyroid carcinoma | Epigenetic Alterations | Expressions of miRNAs in papillary thyroid carcinoma and their associations with the BRAFV600E mutation. | 23416953 |
| F9 gene | Epigenetic Alterations | miRNAs differentially expressed between BRAF(V600E)-positive and -negative PTC tissues were then validated by real-time quantitative PCR on 69 PTC tissues and 69 paracancerous tissues. | 23416953 |
| Hypersensitivity | Epigenetic Alterations | We also focused on four genes with extensive hyper- or hypo-methylation in the muscle lineage (PAX3, TBX1, MYH7B/MIR499 and OBSCN) to compare DNA methylation, DNaseI hypersensitivity, histone modification, and CTCF binding profiles. | 23417056 |
| Neoplasms | Epigenetic Alterations | First, we confirmed transcriptional alterations in genes involved in the oxidative stress induced by MAP17 expression in HeLa cervical tumor cells and found that Hela cells expressing MAP17 were more sensitive to therapies that induce ROS than were parental cells. | 23418532 |
| Cervical Intraepithelial Neoplasia | Epigenetic Alterations | Genome-wide approaches have been used to identify DNA methylation marks associated with CIN persistence or progression. | 23418553 |
| Cervical Intraepithelial Neoplasia | Epigenetic Alterations | However, associations between DNA methylation marks and CIN or ICC remain weak and inconsistent. | 23418553 |
| Kidney Failure, Chronic | Epigenetic Alterations | Likewise, microRNA expression profiling showed a broad overlap between ESRD and healthy donor MSCs. | 23419679 |
| Acute myocardial infarction | Epigenetic Alterations | Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction. | 23420161 |
| Acute myocardial infarction | Epigenetic Alterations | Recent studies have shown that circulating microRNAs might be useful, novel biomarkers for the diagnosis of acute myocardial infarction. | 23420161 |
| Acute myocardial infarction | Epigenetic Alterations | The expression of the cardiac-specific miRNAs in acute myocardial infarction patients decreased to close to the baseline levels at the time of hospital discharge (all p>0.05). | 23420161 |
| Acute myocardial infarction, Troponin T, Cardiac Muscle | Epigenetic Alterations | Our results demonstrate that circulating miR-1, -133a, -208b, and -499 may be useful biomarkers in acute myocardial infarction patients but that these miRNAs are not superior to cardiac troponin T for the diagnosis of acute myocardial infarction. | 23420161 |
| Glioblastoma Multiforme | Epigenetic Alterations | Comparison of microRNA expression levels between initial and recurrent glioblastoma specimens. | 23420397 |
| Glioblastoma Multiforme | Epigenetic Alterations | We selected the following 7 microRNAs with potential relevance for glioblastoma pathobiology by means of a comprehensive literature search: microRNA-10b, microRNA-21, microRNA-181b, microRNA-181c, microRNA-195, microRNA-221 and microRNA-222. | 23420397 |
| Epilepsy, Glioblastoma Multiforme | Epigenetic Alterations | All microRNAs showed detectable levels of expressions in glioblastoma group, whereas microRNA-10b was not detectable in epilepsy patients. | 23420397 |
| Epilepsy, Glioblastoma Multiforme | Epigenetic Alterations | MicroRNAs except microRNA-21 showed significantly higher levels in epilepsy patients when compared to the levels of first resection of glioblastoma. | 23420397 |
| Neoplasms | Epigenetic Alterations | Cox regression analyses showed no significant association of microRNA expression levels in the tumor tissue with progression free survival times. | 23420397 |
| Glioblastoma Multiforme | Epigenetic Alterations | Expression levels of microRNA-10b, microRNA-21, microRNA-181b, microRNA-181c, microRNA-195, microRNA-221 and microRNA-222 do not differ significantly between initial and recurrent glioblastoma. | 23420397 |
| Aggressive behavior, Primary malignant neoplasm, Neoplasm Metastasis | Epigenetic Alterations | MicroRNAs are small RNAs proposed o have important roles for cancer including proliferation, aggressiveness and metastases development. | 23420397 |
| Glioblastoma Multiforme | Epigenetic Alterations | There exist only few data on the involvement of microRNAs in glioblastoma recurrence. | 23420397 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | Objective clinical responses to dacarbazine in patients with metastatic CRC are confined to those tumors harboring epigenetic inactivation of the DNA repair enzyme MGMT. | 23422094 |
| Stomach Carcinoma | Epigenetic Alterations | DNA methylation, dysregulation of miR-34c-5p, and MAPT expression are critical factors in the chemoresistance of gastric cancer to paclitaxel. | 23423488 |
| Primary malignant neoplasm | Epigenetic Alterations | MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. | 23423488 |
| diabetic | Epigenetic Alterations | Histone modifications and recruitment of the nuclear transcriptional factor-kB (p65 subunit) at the MMP-9 promoter and the activity of lysine-specific demethylase 1 (LSD1) were measured in the retina from streptozotocin-induced diabetic rats. | 23423566 |
| Diabetic Retinopathy | Epigenetic Alterations | Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy. | 23423566 |
| Diabetic Retinopathy | Epigenetic Alterations | Human donors with diabetic retinopathy had similar epigenetic changes at the MMP-9 promoter. | 23423566 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are mostly located at cancer-associated genomic regions or in fragile sites, suggesting their important role in the pathogenesis of human cancers. | 23424776 |
| Adenoma | Epigenetic Alterations | To shed light on RCT pathogenesis, we investigated genetic and epigenetic alterations in two cases of pure and composite RCT and compared them with the profiles of matched adenomas and normal mucosa. | 23425390 |
| Stomach Carcinoma | Epigenetic Alterations | Association of microRNA-181c expression with the progression and prognosis of human gastric carcinoma. | 23425811 |
| Lymphoma | Epigenetic Alterations | MiRNAs located in 14q32-31 were underexpressed in splenic marginal zone lymphoma compared with reactive lymphoid tissues and other B-cell lymphomas. | 23429603 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Emerging evidence has shown that microRNAs (miRNAs) participate in human carcinogenesis as tumor suppressors or oncogenes. | 23430406 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs are potentially very useful biomarkers in the diagnosis of cancer. | 23430754 |
| Pancreatic carcinoma | Epigenetic Alterations | We sought to identify specific microRNAs in peripheral blood mononuclear cells (PBMCs) whose levels might facilitate diagnosis of pancreatic cancer. | 23430754 |
| Pancreatic carcinoma, Borderline Personality Disorder | Epigenetic Alterations | First, we used sequencing technology to identify differentially expressed microRNAs in PBMC of pancreatic cancer, BPD, and healthy controls (n = 20 in each group). | 23430754 |
| Malignant tumor of colon, Neoplasms | Epigenetic Alterations | MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7. | 23435373 |
| Malignant Neoplasms | Epigenetic Alterations | Because it is a member of the miR-106b~25 cluster, microRNA-25 (miR-25) is known to be dysregulated in human cancers. | 23435373 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation patterns are associated with the development and prognosis of cancer. | 23436614 |
| Liver carcinoma | Epigenetic Alterations | Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma. | 23437062 |
| Hollings Cancer Center | Epigenetic Alterations | Substantial changes of DNA methylation at a genome-wide level were observed in HCC. | 23437062 |
| Malignant neoplasm of liver, Hollings Cancer Center | Epigenetic Alterations | Understanding epigenetic changes in HCC will help to elucidate the pathogenesis and may eventually lead to identification of molecular markers for liver cancer diagnosis, treatment and prognosis. | 23437062 |
| Primary malignant neoplasm, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Emerging evidence has suggested that circulating microRNAs (miRNAs) could serve as noninvasive biomarkers for cancer detection; however, little is known about circulating miRNA profiles in AML patients. | 23437222 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Identification of circulating microRNAs as potential biomarkers for detecting acute myeloid leukemia. | 23437222 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | These data demonstrated that the expression patterns of circulating miRNAs were systematically altered in AML and miR-181b-5p may serve as a predictor for overall survival in AML patients. | 23437222 |
| Ataxia Telangiectasia, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer. | 23437304 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | miR-18a is one of the most up-regulated miRNAs in colorectal cancers (CRC) based on miRNA profiling. | 23437304 |
| Pathology | Epigenetic Alterations | Our experimental data suggest that a specific set of circulating miRNAs is secreted in the vitreous, which is quite different from the miRNA pattern in serum, and that the quantity of vitreal miRNAs could change, depending on the pathologies of the eye. | 23441115 |
| Humor, Disease | Epigenetic Alterations | MicroRNAs in vitreus humor from patients with ocular diseases. | 23441115 |
| Disease, Vitreous humor | Epigenetic Alterations | Based on evidence that microRNAs (miRNAs) are found in many biologic fluids (e.g., urine, saliva, pleural fluid), we sought to detect the presence of miRNAs and analyze their profile in vitreous humor (VH) from patients affected by various ocular diseases. | 23441115 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Identification of microRNAs regulated by isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic colorectal cancer. | 23441612 |
| ovarian neoplasm | Epigenetic Alterations | Serous ovarian cancer tissues displayed decreased DNA methylation in the promoter region of PARP1 compared to normal tissue, and methylation intensity correlated inversely with PARP1 mRNA levels. | 23442605 |
| Heart failure | Epigenetic Alterations | Increased miRNA levels were strongly associated with increased risk of mortality or heart failure within 30 days for miR-208b (OR 1.79, 95% CI = 1.38-2.23, p = 1 x 10(-5)) and miR-499-5p (OR 1.70, 95% CI = 1.31-2.20, p = 5 x 10(-5)) but the association was lost when adjusting for Troponin T. During surgery miR-208b and miR-499-5p was released in the coronary sinus after cardioplegia-reperfusion to markedly higher levels than in a peripheral vein. | 23448306 |
| Heart failure, Cessation of life | Epigenetic Alterations | Our findings confirm increased levels of cardio-enriched miRNAs in the blood of MI patients and establish association of increased miRNA levels with reduced systolic function after MI and risk of death or heart failure. | 23448306 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Circulating cardio-enriched microRNAs are associated with long-term prognosis following myocardial infarction. | 23448306 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Increased levels of cardio-enriched microRNAs (miRNAs) have been described in patients with myocardial infarction (MI). | 23448306 |
| Heart failure, Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | miRNAs were assessed for discrimination of a clinical diagnosis of myocardial infarction and for association with 30-day mortality and diagnosis of heart failure. | 23448306 |
| Liver carcinoma | Epigenetic Alterations | Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma. | 23449122 |
| Malignant neoplasm of kidney | Epigenetic Alterations | In addition to HIF-1 regulating miR-210 in renal cancer, HIF-2 can regulate this microRNA in the absence of HIF-1. | 23449350 |
| Malignant neoplasm of kidney | Epigenetic Alterations | MicroRNA-210 is upregulated in renal cancer compared with normal renal cortex tissue. | 23449350 |
| Neoplasms | Epigenetic Alterations | Exosomal microRNA (miR) content differed between MM and normal BM-MSCs, with a lower content of the tumor suppressor miR-15a. | 23454749 |
| Carcinogenesis, Aneuploidy | Epigenetic Alterations | Subsequent acquisition of aneuploidy leads to subtle but distinct transcriptional alterations, revealing novel target genes that drive genomic instability and thus carcinogenesis. | 23455720 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-335 acts as a candidate tumor suppressor in prostate cancer. | 23456549 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-335 (miR-335) acts as a tumor suppressor or a tumor promoter in different human malignancies. | 23456549 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The loss of this microRNA might be associated with clinical progression of PCa patients. | 23456549 |
| Colorectal Cancer Pathway | Epigenetic Alterations | A plasma microRNA panel for early detection of colorectal cancer. | 23456911 |
| Clinical Coordinator, Neoplasm Metastasis | Epigenetic Alterations | Moreover, the diagnostic performance of the microRNA panel persisted in nonmetastasis CRC stages (Dukes A-B, AUC: 0.809 and 0.892 for training and validation dataset, respectively) and in metastasis CRC stages (Dukes C-D, AUC: 0.917 and 0.865 for training and validation dataset, respectively). | 23456911 |
| Clinical Coordinator | Epigenetic Alterations | In conclusion, our study reveals a plasma microRNA panel that has potential clinical value in early CRC detection and would play a critical role on preliminarily screening CRC in general population. | 23456911 |
| Papillary neoplasm | Epigenetic Alterations | MicroRNA-146a targets PRKCE to modulate papillary thyroid tumor development. | 23457043 |
| SERPINB3 wt Allele | Epigenetic Alterations | Our results indicate that microRNA polymorphisms modify the risk of OSCC associated with HPV16 seropositivity, particularly in patients with SCCOP and never smokers. | 23457596 |
| Communicable Diseases, Squamous cell carcinoma, SERPINB3 wt Allele | Epigenetic Alterations | Both microRNAs and human papillomavirus (HPV) infection play an important role in the development and progression of oral squamous cell carcinoma (OSCC). | 23457596 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are small non-coding genes which become dysregulated in cancer and may predict survival. | 23458262 |
| Metastasis | Epigenetic Alterations | Three miRNA sets were significantly associated with overall survival (miR-107, miR-151, miR-492; P = 0.0002), disease-free survival (miR-20b, miR-107, miR-151, miR-182, miR-361; P = 0.0001), and distant metastasis (miR-151, miR-152, miR-324-5p, miR-361, miR492; P = 0.0087), which retained significance even after adjusting for p16 status. | 23459718 |
| Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma | Epigenetic Alterations | Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma. | 23459718 |
| Malignant Neoplasms | Epigenetic Alterations | Deregulation of miRNAs is associated with almost all human malignancies. | 23459718 |
| Metastasis | Epigenetic Alterations | The associated biologic functions of these miRNAs include immune surveillance, treatment resistance, invasion, and metastasis. | 23459718 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) are endogenous small noncoding RNAs that negatively regulate gene expression at the posttranscriptional level and play an important role in carcinogenesis. | 23461060 |
| Malignant Neoplasms | Epigenetic Alterations | Then, we validated the detective ability of this miRNA panel in a testing set of 34 malignant tumor patients, 30 patients with benign pulmonary nodules and 32 healthy smokers. | 23462458 |
| Carcinoma of lung | Epigenetic Alterations | Identification of plasma microRNAs as novel noninvasive biomarkers for early detection of lung cancer. | 23462458 |
| Carcinoma of lung | Epigenetic Alterations | Using quantitative reverse transcriptase PCR analysis, we first selected and identified three aberrant plasma expression miRNAs (miR-21, miR-145, and miR-155) in a training set of 62 patients and 60 healthy smokers to define a panel that had high diagnostic efficiency for lung cancer. | 23462458 |
| Carcinoma of lung | Epigenetic Alterations | The three miRNAs used in combination produced the area under receiver operating characteristic curve at 0.847, which helped distinguish lung cancer from healthy smokers with 69.4% sensitivity and 78.3% specificity. | 23462458 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. | 23462794 |
| WFS1 gene | Epigenetic Alterations | Successful DNA methylation data were generated for 16 of these 19 CpG-SNP loci, representing the candidate genes TCF7L2, KCNQ1, PPARG, HHEX, CDKN2A, SLC30A8, DUSP9, CDKAL1, ADCY5, SRR, WFS1, IRS1, DUSP8, HMGA2, TSPAN8 and CHCHD9. | 23462794 |
| WFS1 gene | Epigenetic Alterations | Moreover, six CpG-SNPs, representing TCF7L2, KCNQ1, CDKN2A, ADCY5, WFS1 and HMGA2, were also associated with DNA methylation of surrounding CpG sites. | 23462794 |
| Diabetes Mellitus | Epigenetic Alterations | Our results suggest that the introduction or removal of a CpG site may be a molecular mechanism through which some of the type 2 diabetes SNPs affect gene function via differential DNA methylation and consequently contributes to the phenotype of the disease. | 23462794 |
| B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Low expression of microRNA-129-5p predicts poor clinical outcome in diffuse large B cell lymphoma (DLBCL). | 23463124 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | MicroRNA expression provides a new and interesting tool for understanding the biology and clinical course of DLBCL. | 23463124 |
| Neoplasms | Epigenetic Alterations | No significant difference was found among microRNA-129-5p expression in tumor tissue, the tissue surrounding the tumor, and normal controls. | 23463124 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | To our knowledge, this is the first report to show that the expression of microRNA-129-5p can affect the clinical outcome of DLBCL patients and that microRNA-129-5p may be involved in the biology of DLBCL development, although larger studies are necessary to confirm this. | 23463124 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Further investigations may also help to elucidate the biological role of microRNA-129-5p in DLBCL. | 23463124 |
| Functional disorder, Coronary Artery Disease | Epigenetic Alterations | MicroRNA (miRNA) expression profiles in endothelial progenitor cells (EPCs) contribute to EPC dysfunction in patients suffering from coronary artery disease. | 23465244 |
| Extracellular Matrix | Epigenetic Alterations | Sixteen miRNAs (miR-126, miR-508-5p, miR-34a, miR-210, miR-490-3p, miR-513-5p, miR-517c, miR-518e, miR-589, miR-220c, miR-200a*, miR-186*, miR-7i*, miR-200b*, miR-595, and miR-662) were found to be differentially expressed between ICM and NICM patients. | 23465244 |
| Congestive heart failure, Extracellular Matrix | Epigenetic Alterations | The miRNAs miR-126 and miR-508-5p are associated with the outcome of ICM and NICM patients with CHF. | 23465244 |
| Congestive heart failure | Epigenetic Alterations | These two miRNAs could be useful in the diagnosis of CHF patients, and might provide novel targets for prevention and treatment of CHF. | 23465244 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Increasing evidence has lent support to the notion that miRNAs regulate hepatocellular carcinoma (HCC) cell proliferation by directly targeting cell cycle-related genes. | 23466643 |
| Barrett Esophagus | Epigenetic Alterations | MicroRNA expression signatures during malignant progression from Barretts esophagus to esophageal adenocarcinoma. | 23466817 |
| Barrett Esophagus | Epigenetic Alterations | The majority of miRNA aberrations involved upregulation of expression in Barretts esophagus and esophageal adenocarcinoma tissues, with the most dramatic alterations occurring at the Barretts metaplasia stage. | 23466817 |
| Barrett Esophagus, Adenocarcinoma Of Esophagus | Epigenetic Alterations | The significant miRNA alterations that were exclusive to esophageal adenocarcinoma but not Barretts esophagus included miR-375 downregulation and upregulation of five members of the miR-17-92 and its homologue clusters, which may become promising biomarkers for esophageal adenocarcinoma development. | 23466817 |
| Barrett Esophagus, Neoplasms | Epigenetic Alterations | Known oncomiRs, such as miR-21, miR-25, and miR-223, and tumor suppressor miRNAs, including miR-205, miR-203, let-7c, and miR-133a, showed progressively altered expression from Barretts esophagus to esophageal adenocarcinoma. | 23466817 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic analyses have shown that aberrant DNA methylation signatures are associated with breast cancer molecular subtypes. | 23467623 |
| Breast Carcinoma | Epigenetic Alterations | By using pyrosequencing, we analyzed the DNA methylation status of 5 candidate genes in 60 breast cancer samples. | 23467623 |
| Breast Carcinoma | Epigenetic Alterations | Our results indicate that the basal-like subtype is associated with low methylation levels of the SFRP1 gene, suggesting that the methylation levels of specific breast cancer genes may potentially serve as epigenetic biomarkers and prognostic factors. | 23467623 |
| Damper Device, Breast Carcinoma | Epigenetic Alterations | Dampening enthusiasm for circulating microRNA in breast cancer. | 23472110 |
| Breast Carcinoma | Epigenetic Alterations | Genome-wide platforms for high-throughput profiling of circulating miRNA (oligoarray or miR-Seq) offer enormous promise for agnostic discovery of circulating miRNA biomarkers as a pathway for development in breast cancer detection. | 23472110 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidences indicate that dysregulated microRNAs (miRNA) are involved in cancer tumorigenesis and progression. | 23474644 |
| Cholangiocarcinoma | Epigenetic Alterations | Classification of mid/distal bile duct cancer by both genetic and epigenetic profiles may improve the accuracy in predicting outcome and the effectiveness of tailored therapy in these diseases. | 23478949 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Expression of type 2 orexin receptor in human endometrium and its epigenetic silencing in endometrial cancer. | 23482607 |
| Hepatitis C Virus-Related Hepatocellular Carcinoma | Epigenetic Alterations | ABCB6 mRNA and DNA methylation levels serve as useful biomarkers for prediction of early intrahepatic recurrence of hepatitis C virus-related hepatocellular carcinoma. | 23483087 |
| childhood nasal type extranodal NK/T-cell lymphoma | Epigenetic Alterations | [Expression of MCL-1 and microRNA-29a in extranodal NK/T-cell lymphoma tissue]. | 23484699 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-21 as an indicator of aggressive phenotype in breast cancer. | 23485999 |
| Liver carcinoma | Epigenetic Alterations | MiR-124 and miR-203 function as tumor-suppressor microRNAs silenced by DNA methylation in hepatocellular carcinoma. | 23487440 |
| Breast Carcinoma, Metastasis, Neoplasms | Epigenetic Alterations | Senescence-associated microRNA, miR-22, suppresses tumor growth and metastasis in vivo in a murine breast cancer model, and exosomal senescence-associated microRNA may affect the tumor microenvironment. | 23487440 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs in Cancer: the 22nd Hiroshima Cancer Seminar/the 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima. | 23487440 |
| Breast Cancer Cell, Primary malignant neoplasm, Carcinogenesis | Epigenetic Alterations | The joint international symposium of the 22nd Hiroshima Cancer Seminar and the 4th Japanese Association for RNA Interference focused on a pivotal role of microRNAs in carcinogenesis, progression and therapy of human cancer. | 23487440 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | The therapeutic potential of microRNAs for preventing and treating lung cancer using the Kras(LSL-G12D/+);p53(LSL-R172H/+)mouse model suggests that miR-34 may be useful in sensitizing tumors to other conventional therapeutics. | 23487440 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Expression profile of microrna-145 in urothelial bladder cancer. | 23489501 |
| MS gene | Epigenetic Alterations | Circulating microRNAs as biomarkers for disease staging in multiple sclerosis. | 23494648 |
| Antilymphocyte Serum, Amyotrophic Lateral Sclerosis | Epigenetic Alterations | Interestingly, the same circulating miRNAs (let-7 and miR-92) that were differentially expressed in RRMS versus SPMS also differentiated amyotrophic lateral sclerosis (ALS) from RRMS subjects, but were not different between SPMS and ALS, suggesting that similar processes may occur in SPMS and ALS. | 23494648 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant DNA methylation is a common epigenetic alteration and an important feature in human cancers. | 23495895 |
| ovarian neoplasm, Primary malignant neoplasm | Epigenetic Alterations | Although we still have a long way to go before an effective and nontoxic miRNA-based cancer therapy can be introduced into the clinic, the inhibition of integrin a5 expression by targeting miR-92a needs to be explored further for future applications in ovarian cancer treatment. | 23499550 |
| Atrial Fibrillation | Epigenetic Alterations | Regulation of the SK3 channel by microRNA-499--potential role in atrial fibrillation. | 23499625 |
| Atrial Fibrillation | Epigenetic Alterations | MicroRNAs are important regulators of gene expression, including those involving electrical remodeling in atrial fibrillation (AF). | 23499625 |
| Prostate Cancer Pathway | Epigenetic Alterations | Prostatic concentrations of 1,25D positively correlated with these miRNA levels in both prostate cancer and benign epithelium, showing that patients with prostate cancer may still benefit from vitamin D3. | 23503652 |
| Prostate Lymphoma, Neoplasms | Epigenetic Alterations | Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue. | 23503652 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Together, these findings show that vitamin D3 supplementation augments tumor suppressive miRNAs in patient prostate tissue, providing evidence that miRNAs could be key physiologic mediators of vitamin D3 activity in prevention and early treatment of prostate cancer. | 23503652 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic regulations including DNA methylation and histone modification control gene expression and play important roles during cancer progression. | 23504335 |
| Degenerative polyarthritis | Epigenetic Alterations | Alterations in DNA methylation patterns have been found to correlate with several diseases including osteoarthritis (OA). | 23505229 |
| Degenerative polyarthritis | Epigenetic Alterations | DNA methylation profiling was performed using Illumina Infinium HumanMethylation27 in 25 patients with OA and 20 healthy controls. | 23505229 |
| Degenerative polyarthritis | Epigenetic Alterations | We were able to identify a tight subgroup of patients with OA, characterised by an increased inflammatory response that could be regulated by epigenetics. | 23505229 |
| Glioma | Epigenetic Alterations | Altered expression of MGMT in high-grade gliomas results from the combined effect of epigenetic and genetic aberrations. | 23505468 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes? | 23505498 |
| Diabetes Mellitus, Non-Insulin-Dependent, Islets of Langerhans | Epigenetic Alterations | Epigenetics may play a role in the pathophysiology of type 2 diabetes (T2D), and increased DNA methylation of the metabolic master regulator peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) has been reported in muscle and pancreatic islets from T2D patients and in muscle from individuals at risk of T2D. | 23505498 |
| Family | Epigenetic Alterations | No significant effect of familiality on DNA methylation was found. | 23505498 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Taken together, increased DNA methylation of the PPARGC1A promoter is unlikely to play a major causal role for the development of insulin resistance in FDR of patients with T2D. | 23505498 |
| Colorectal Cancer Pathway, Loss of Heterozygosity | Epigenetic Alterations | Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients. | 23505554 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Our goal was to characterize the relationships between CSMD1 somatic mutations, allele imbalance, DNA methylation, and the clinical characteristics in colorectal cancer patients. | 23505554 |
| Colorectal Neoplasms | Epigenetic Alterations | Finally, we performed methylation-specific PCR on 76 colorectal tumors to determine DNA methylation status for CSMD1 and known methylation targets ALX4, RUNX3, NEUROG1, and CDKN2A. | 23505554 |
| Colorectal Cancer Pathway | Epigenetic Alterations | High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer. | 23506979 |
| Malignant tumor of colon | Epigenetic Alterations | Finally, we also found that these miRNAs were up-regulated in oxaliplatin resistant HCT116/oxPt (miR-625-3p, miR-181b and miR-27b) and LoVo/oxPt (miR-181b) colon cancer cell lines as compared with their isogenic parental cells. | 23506979 |
| Injury of liver | Epigenetic Alterations | Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B. | 23508904 |
| Communicable Diseases, Hepatitis B | Epigenetic Alterations | Hepatitis B virus (HBV) infection is associated with increased expression of microRNA-122. | 23508904 |
| Fibrosis Assessment | Epigenetic Alterations | MicroRNA-122 levels were also lower in patients with advanced liver fibrosis (P < 0.001) and lower inflammatory activity (P < 0.025). | 23508904 |
| Hepatitis B | Epigenetic Alterations | Association of polymorphism in MicroRNA 219-1 with clearance of hepatitis B virus infection. | 23508906 |
| Communicable Diseases, Hepatitis B | Epigenetic Alterations | Polymorphisms in the primary microRNA region may be associated with natural course of hepatitis B virus (HBV) infection. | 23508906 |
| Communicable Diseases | Epigenetic Alterations | This result suggests that polymorphisms in the pri-miRNA region of miR-219-1 might be a genetic factor for HBV clearance after infection. | 23508906 |
| Leukoplakia | Epigenetic Alterations | We identified a specific miRNA signature that is aberrantly expressed in progressing oral LGD leukoplakias. | 23510112 |
| Primary malignant neoplasm | Epigenetic Alterations | These results show promise for using saliva miRNA signature for monitoring of cancer precursor lesions and early detection of disease progression. | 23510112 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is an epigenetic process which has been involved as an important pathogenic factor of cancer. | 23513484 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Recently, emerging studies have suggested that an aberrant microRNA (miRNA) expression signature exists in ESCC. | 23516093 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Thus, our data present new evidence for the important roles of miRNAs in ESCC. | 23516093 |
| Acute myocardial infarction | Epigenetic Alterations | Aspirin protects human coronary artery endothelial cells against atherogenic electronegative LDL via an epigenetic mechanism: a novel cytoprotective role of aspirin in acute myocardial infarction. | 23519265 |
| Neoplasms | Epigenetic Alterations | The expression of let-7a miRNA in serum, tumor tissues, and peritumoral tissues was measured by real-time PCR. | 23519840 |
| Gastric Adenocarcinoma, Neoplasms | Epigenetic Alterations | The let-7a miRNA levels in the serum and tumor tissues of gastric adenocarcinoma patients were significantly lower than in the serum of healthy controls and peritumoral tissues, respectively. | 23519840 |
| Gastric Adenocarcinoma | Epigenetic Alterations | Dicer 1 protein positively correlated with let-7a miRNA level, but negatively correlated with CCR7 protein level in gastric adenocarcinoma. | 23519840 |
| Tetranitromethane, Metastasis, Neoplasms | Epigenetic Alterations | Negative Dicer 1 protein and let-7a miRNA expression and positive CCR7 protein expression significantly correlated with lymph node metastasis, depth of invasion, high clinical TNM stage, and larger tumor size. | 23519840 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | High expression of CCR7 protein and low expression of Dicer 1 protein and let-7a miRNA are significantly associated with the metastasis and progression of gastric cancer. | 23519840 |
| Stomach Carcinoma | Epigenetic Alterations | High CCR7 protein expression may be caused by the loss of Dicer 1 protein expression and reduced let-7a miRNA level in gastric cancer. | 23519840 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Our results indicated that LRP1B was frequently downexpressed in human RCC tissue and cell lines, which involved both epigenetic events (DNA methylation and histone deacetylation) and N-terminal deletion of LRP1B. | 23521319 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway | Epigenetic Alterations | Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer. | 23523318 |
| Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | In chronic lymphocytic leukemia (CLL) patients, disruptions of the TP53 tumor suppressor pathway by 17p13 deletion (del17p), somatic TP53 mutations, or downregulation of microRNA-34a have been associated with a poor prognosis. | 23525797 |
| Breast Carcinoma | Epigenetic Alterations | Our results suggest that germline variation in the 5 region proximal to pre-miRNA gene sequences may be associated with breast cancer risk among African Americans and breast cancer-specific survival generally; however, further validation is needed to confirm these findings. | 23526039 |
| Liver carcinoma | Epigenetic Alterations | Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. | 23526469 |
| Chronic liver disease, Hollings Cancer Center | Epigenetic Alterations | Loss of SIRT6 induces epigenetic changes that may be relevant to chronic liver disease and HCC development. | 23526469 |
| Hollings Cancer Center, Primary malignant neoplasm | Epigenetic Alterations | Our data demonstrate that deficiency in one epigenetic regulator predisposes a tumorigenic phenotype that ultimately has relevance for outcome of HCC and other cancer patients. | 23526469 |
| Breast Carcinoma | Epigenetic Alterations | Downregulation of miRNA-128 sensitises breast cancer cell to chemodrugs by targeting Bax. | 23526655 |
| Urinary Bladder, Schistosomiasis | Epigenetic Alterations | Here we evaluated aberrant promoter DNA methylation as a potential biomarker to detect severe bladder damage that is associated with schistosomiasis by analyzing urine specimens. | 23527093 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Neoplasms | Epigenetic Alterations | Epigenetic alterations of the transcription factor 21 (TCF21) gene have been associated with head and neck squamous cell carcinoma (HNSCC) and other tumor entities. | 23529585 |
| Squamous cell carcinoma of the head and neck, Human papilloma virus infection | Epigenetic Alterations | These epigenetic, and possibly also genetic, alterations of the TCF21 gene in HNSCCs may be driven by HPV infection, nicotine and alcohol abuse, or both. | 23529585 |
| Nasopharyngeal carcinoma, Metastasis, Neoplasms | Epigenetic Alterations | Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. | 23529758 |
| SCYL1 gene | Epigenetic Alterations | We show that EZH2 upregulation is mediated by MYC-induced repression of its regulatory micro RNAs and EZH2 exerts oncogenic properties in NKTL. | 23529930 |
| Endometrial Carcinoma | Epigenetic Alterations | Epigenetic regulation of L1CAM in endometrial carcinoma: comparison to cancer-testis (CT-X) antigens. | 23530769 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | The acetylation status of histones is involved in the epigenetic control of gene expression and is usually disrupted in advanced thyroid cancer. | 23531031 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery. | 23532818 |
| Papillary thyroid carcinoma | Epigenetic Alterations | Differential expression profiling and functional analysis of microRNAs through stage I-III papillary thyroid carcinoma. | 23533107 |
| F9 gene | Epigenetic Alterations | Biological function analysis showed that target genes were involved in five aspects including cell proliferation, differentiation, apoptosis, cycle, and signaling transduction pathway, suggesting the regulatory role of abnormal expression of critical miRNAs in the pathogenesis of PTC. | 23533107 |
| Chordoma | Epigenetic Alterations | Chordoma characterization of significant changes of the DNA methylation pattern. | 23533570 |
| Chordoma | Epigenetic Alterations | In summary, we have shown that chordomas are characterized by a significant genomic instability and furthermore we demonstrated a characteristic DNA methylation pattern. | 23533570 |
| Stomach Carcinoma | Epigenetic Alterations | Diet folate, DNA methylation and polymorphisms in methylenetetrahydrofolate reductase in association with the susceptibility to gastric cancer. | 23534741 |
| Stomach Carcinoma | Epigenetic Alterations | Methylenetetrahydrofolate reductase (MTHFR) has been reported to be associated with DNA methylation, an epigenetic feature frequently found in gastric cancer. | 23534741 |
| Sarcoma - category (morphologic abnormality) | Epigenetic Alterations | Growth rate of late passage sarcoma cells is independent of epigenetic events but dependent on the amount of chromosomal aberrations. | 23535008 |
| Sarcoma | Epigenetic Alterations | Soft tissue sarcomas (STS) are characterized by co-participation of several epigenetic and genetic events during tumorigenesis. | 23535008 |
| Gain, Primary malignant neoplasm | Epigenetic Alterations | Collectively, our data demonstrate that these fairly differentiated/advanced cancer cell lines have still the potential to gain an additional spontaneous growth benefit without external influences and that maintenance of increased proliferative potential towards longevity of STS cells (having crossed senescence barriers) may be independent of overt epigenetic alterations. | 23535008 |
| Childhood Leukemia | Epigenetic Alterations | Recently, epigenetic regulation of CEBPA expression through DNA methylation has been demonstrated in leukemia. | 23541085 |
| ovarian neoplasm | Epigenetic Alterations | Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. | 23542579 |
| Breast Cancer Cell | Epigenetic Alterations | Recent studies have suggested that miRNA deregulation is associated with the initiation and progression of human cancer. | 23542579 |
| Primary malignant neoplasm, Ascites | Epigenetic Alterations | Out of 2222 kinds of total miRNAs that were identified in the microarray analysis, 95 miRNAs were down-regulated and 88 miRNAs were up-regulated, in the serum, tissue, and ascites of cancer patients. | 23542579 |
| ovarian neoplasm | Epigenetic Alterations | Among the miRNAs that showed a consistent regulation tendency through all specimens and showed more than a 2-fold difference in serum, 5 miRNAs (miR-132, miR-26a, let-7b, miR-145, and miR-143) were determined as the 5 most markedly down-regulated miRNAs in the serum from ovarian cancer patients with respect to those of controls. | 23542579 |
| ovarian neoplasm | Epigenetic Alterations | Four miRNAs (miR-132, miR-26a, let-7b, and miR-145) out of 5 selected miRNAs were significantly underexpressed in the serum of ovarian cancer patients in qRT-PCR. | 23542579 |
| ovarian neoplasm | Epigenetic Alterations | Also, serum miRNAs is a promising and useful tool for discriminating between controls and patients with serous ovarian cancer. | 23542579 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | DNA methylation profiles at precancerous stages associated with recurrence of lung adenocarcinoma. | 23544068 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | The aim of this study was to clarify the significance of DNA methylation alterations at precancerous stages of lung adenocarcinoma. | 23544068 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Stepwise progression of DNA methylation alterations from normal lung tissue to non-cancerous lung tissue obtained from patients with lung adenocarcinomas, and then tumorous tissue samples, was observed at 3,270 CpG sites, suggesting that non-cancerous lung tissue obtained from patients with lung adenocarcinomas was at precancerous stages with DNA methylation alterations. | 23544068 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | At CpG sites of 2,083 genes, DNA methylation status in samples of non-cancerous lung tissue obtained from patients with lung adenocarcinomas was significantly correlated with recurrence after establishment of lung adenocarcinomas. | 23544068 |
| Aggressive behavior | Epigenetic Alterations | These data suggest that DNA methylation alterations at precancerous stages determine tumor aggressiveness and outcome through silencing of specific genes. | 23544068 |
| Acute myocardial infarction | Epigenetic Alterations | MicroRNA-150: a novel marker of left ventricular remodeling after acute myocardial infarction. | 23547171 |
| Neoplasms | Epigenetic Alterations | MicroRNAs have been reported to play roles as oncogenes or tumor suppressor genes in human cancers. | 23548968 |
| Neoplasms | Epigenetic Alterations | ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance. | 23549872 |
| Breast Carcinoma | Epigenetic Alterations | These findings support the hypothesis that a SNP located in igf-1r gene may alter miRNA regulation of IGF-1R, with a putative effect on BRCA1 penetrance and breast cancer risk. | 23549953 |
| Hollings Cancer Center | Epigenetic Alterations | These results demonstrate the potential of MALDI IMS for uncovering new relevant biomarkers of MiVI in HCC, and highlight the role of epigenetic modifications in the prognosis of HCC. | 23553687 |
| Primary Neoplasm, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Our observations suggest that cancer cells in omental tumors express key miRNAs differently than primary tumors, and that at least some of these microRNAs may be critical regulators of the emergence of drug resistant disease. | 23554878 |
| ovarian neoplasm | Epigenetic Alterations | Identification of ovarian cancer metastatic miRNAs. | 23554878 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer. | 23554959 |
| Malignant Neoplasms | Epigenetic Alterations | Genistein has been shown to inhibit cancers both in vitro and in vivo, by altering the expression of several microRNAs (miRNAs). | 23554959 |
| Hormone refractory prostate cancer | Epigenetic Alterations | We used Enhanced Reduced Representation Bisulfite Sequencing, a genome-wide high-coverage single-base resolution DNA methylation method to profile seven localized PCa samples, seven matched benign prostate tissues, and six aggressive castration-resistant prostate cancer (CRPC) samples. | 23555183 |
| Neoplasms | Epigenetic Alterations | We found that most DNA methylation changes occurred in the context of ASM, suggesting that variations in tumor epigenetic landscape of individuals are partly mediated by genetic differences, which may affect PCa disease progression. | 23555183 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | We further selected a panel of 13 CGIs demonstrating increased DNA methylation with disease progression and validated this panel in an independent cohort of 20 benign prostate tissues, 16 PCa, and 8 aggressive CRPCs. | 23555183 |
| Primary malignant neoplasm | Epigenetic Alterations | Several of the most significantly altered loci (CAV1, EVX1, MCF2L, and FGF1) were then used as probes to map the extent of these DNA methylation changes in normal tissues from prostates containing cancer. | 23555185 |
| CHOANAL ATRESIA, POSTERIOR, Peripheral zone of prostate | Epigenetic Alterations | These mapping studies indicate that a spatially widespread epigenetic defect occurs in the peripheral prostate tissues of men who have PCa that may be useful in the detection of this disease. | 23555185 |
| Breast Carcinoma | Epigenetic Alterations | There is no association between microRNA gene polymorphisms and risk of triple negative breast cancer in a Chinese Han population. | 23555923 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miRNA) as a novel modulator of gene expression has played an important regulatory role in the malignancy. | 23555923 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant expression of microRNA-146a (miR-146a) has been reported to be involved in the development and progression of various types of cancers. | 23555954 |
| Neoplasms | Epigenetic Alterations | Global histone modification patterns correlate with tumor phenotypes and prognostic factors in multiple tumor types. | 23557258 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent studies suggest that aberrant histone modifications play an important role in cancer. | 23557258 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma. | 23558898 |
| Malignant Neoplasms, Maxillary Sinus Squamous Cell Carcinoma | Epigenetic Alterations | Our recent studies of microRNA (miRNA) expression signature demonstrated that microRNA-874 (miR-874) was significantly downregulated in maxillary sinus squamous cell carcinoma (MSSCC), and a putative tumour-suppressive miRNA in human cancers. | 23558898 |
| Primary malignant neoplasm | Epigenetic Alterations | Recognition of tumour-suppressive miRNA-mediated cancer pathways provides new insights into the potential mechanisms of HNSCC oncogenesis and suggests novel therapeutic strategies for the disease. | 23558898 |
| Primary malignant neoplasm, Uterine Corpus Sarcoma, Neoplasms | Epigenetic Alterations | As aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expression profiles of the major uterine sarcoma subtypes and mixed epithelial-mesenchymal tumors of the uterus. | 23558962 |
| Uterine Neoplasms, Uterine Corpus Sarcoma | Epigenetic Alterations | microRNAs in uterine sarcomas and mixed epithelial-mesenchymal uterine tumors: a preliminary report. | 23558962 |
| Carcinoma of lung, Pneumonia, Tuberculosis, Pulmonary | Epigenetic Alterations | Differential microRNAs expression in serum of patients with lung cancer, pulmonary tuberculosis, and pneumonia. | 23559272 |
| Tuberculosis, Pulmonary, Carcinoma of lung, Infectious Lung Disorder, Pneumonia, Primary malignant neoplasm | Epigenetic Alterations | Several studies have shown that aberrant expression of miRNAs in human cancer including lung cancer, but little is known about their effects on some infectious lung diseases such as pulmonary tuberculosis (TB) and pneumonia. | 23559272 |
| Esophageal carcinoma | Epigenetic Alterations | Salivary microRNAs as promising biomarkers for detection of esophageal cancer. | 23560033 |
| Malignant Neoplasms | Epigenetic Alterations | Tissue microRNAs (miRNAs) can detect cancers and predict prognosis. | 23560033 |
| Esophageal carcinoma | Epigenetic Alterations | By Agilent microarray, six deregulated miRNAs from whole saliva samples from seven patients with esophageal cancer and three healthy controls were selected. | 23560033 |
| Esophageal carcinoma | Epigenetic Alterations | The six selected miRNAs were subjected to validation of their expression levels by RT-qPCR using both whole saliva and saliva supernatant samples from an independent set of 39 patients with esophageal cancer and 19 healthy controls. | 23560033 |
| Esophageal carcinoma | Epigenetic Alterations | We found distinctive miRNAs for esophageal cancer in both whole saliva and saliva supernatant. | 23560033 |
| Esophageal carcinoma | Epigenetic Alterations | These miRNAs possess discriminatory power for detection of esophageal cancer. | 23560033 |
| Esophageal carcinoma | Epigenetic Alterations | Because saliva collection is noninvasive and convenient, salivary miRNAs show great promise as biomarkers for detection of esophageal cancer in areas at high risk. | 23560033 |
| Metastasis | Epigenetic Alterations | Interestingly, the expression levels of these miRNAs were also shown to be upregulated in widely invasive FTC (WI-FTC; n=13) that has distant metastasis and worse prognosis, indicating a close similarity in the miRNA expression between metastatic MI-FTC and WI-FTC. | 23563786 |
| Squamous cell carcinoma, SERPINB3 wt Allele | Epigenetic Alterations | Oral squamous cell carcinoma (OSCC) development involves complex machinery of genomic and epigenetic regulations including microRNA (miRNA) expression changes. | 23564792 |
| Squamous cell carcinoma | Epigenetic Alterations | miRNA expression profiles of oral squamous cell carcinomas. | 23564792 |
| Tetranitromethane, SERPINB3 wt Allele | Epigenetic Alterations | We aimed to analyze the expression patterns of a set of miRNAs in human TNM stage I and II OSCC samples in an autologous normal mucosa-controlled experimental design. | 23564792 |
| Infection caused by Helicobacter pylori, Carcinogenesis | Epigenetic Alterations | Interleukin polymorphisms and Helicobacter pylori infection are believed to play critical roles in DNA methylation, a process frequently associated with carcinogenesis. | 23566094 |
| Stomach Carcinoma | Epigenetic Alterations | DNA methylation in gastric cancer seems to be influenced by the presence of interleukin polymorphisms and by the H. pylori cagA/vacAs1m1 strains. | 23566094 |
| Septicemia | Epigenetic Alterations | Sepsis and systemic inflammatory response syndrome induce considerable changes of methylation metabolism without apparent functional consequences on homocysteine plasma levels or DNA methylation. | 23566119 |
| Childhood Medulloblastoma | Epigenetic Alterations | Epigenetic Silencing of DKK3 in medulloblastoma. | 23567267 |
| Clinical Coordinator | Epigenetic Alterations | Subsequently, we tried to correlate expression levels of analyzed miRNAs to clinical-pathological features of CRC patients. | 23568010 |
| Neoplasms | Epigenetic Alterations | To study epigenetics in clear-cell ovarian cancer, fresh frozen tumor DNA (n = 485) was assayed on Illumina Infinium HumanMethylation450 BeadChips. | 23571109 |
| Neoplasms | Epigenetic Alterations | Several loci methylation inversely correlated with tumor gene expression, most notably KCNH2 (HERG, a potassium channel) (P = 9.5 x 10(-7)), indicating epigenetic silencing. | 23571109 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer (CRC) development involves underlying modifications at genetic/epigenetic level. | 23573237 |
| Neoplasms | Epigenetic Alterations | The Lenti-miRNA-VEGF-A+VEGF-C significantly inhibited the cell proliferation and tumor growth, compared with Lenti-miRNA-VEGF-A or Lenti-miRNA-VEGF-C (P<0.05). | 23573305 |
| Neoplasms | Epigenetic Alterations | In addition, Lenti-miRNA- VEGF-A+VEGF-C markedly lowered the tumor size in vivo in comparison with Lenti-miRNA-VEGF-A or Lenti-miRNA-VEGF-C (P<0.05). | 23573305 |
| Osteosarcoma | Epigenetic Alterations | MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma. | 23574781 |
| Osteosarcoma | Epigenetic Alterations | The investigation of miRNA expression between healthy subjects and patients with osteosarcoma is crucial for future clinical trials. | 23574781 |
| Osteosarcoma | Epigenetic Alterations | miRNA profiling of osteosarcoma tissue samples showed that expression of 10 miRNAs had increased 10-fold compared with normal controls. | 23574781 |
| Disease | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in the development, differentiation, and function of different cell types and in the pathogenesis of various human diseases. | 23574781 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNAs are differentially expressed in normal and cancer cells. | 23574781 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | While no miRNA alone differentiated localized PCa and mCRPC, combinations had greater sensitivity and specificity. | 23574937 |
| Metastatic castration-resistant prostate cancer | Epigenetic Alterations | Plasma miRNAs as biomarkers to identify patients with castration-resistant metastatic prostate cancer. | 23574937 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | We identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. | 23574937 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our results demonstrate that plasma levels of selected miRNAs are potential biomarkers to differentiate localized PCa and mCRPC. | 23574937 |
| Neoplasms | Epigenetic Alterations | Discovery and prevalidation of salivary extracellular microRNA biomarkers panel for the noninvasive detection of benign and malignant parotid gland tumors. | 23575476 |
| Malignant Neoplasms | Epigenetic Alterations | A four miRNA combination was able to discriminate between saliva samples from patients with malignant tumors from those of patients with benign parotid gland tumors (sensitivity 69%, specificity 95%). | 23575476 |
| Neoplasms | Epigenetic Alterations | Salivary miRNA profiles differ in saliva from patients with malignant from saliva from patients with a benign parotid gland tumor. | 23575476 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | We measured DNA methylation at 27578 CpGs in blood samples from 298 women who developed breast cancer 0 to 5 years after enrollment in the Sister Study cohort and compared them with a random sample of 612 cohort women who remained cancer free. | 23578854 |
| Liver carcinoma | Epigenetic Alterations | Frequent DNA methylation of MiR-129-2 and its potential clinical implication in hepatocellular carcinoma. | 23580407 |
| Carcinogenesis | Epigenetic Alterations | Recently, microRNAs have been shown to play an important role in carcinogenesis, being regulated by DNA methylation in several cases. | 23580407 |
| Neoplasms | Epigenetic Alterations | Our data suggest that GPX7 possesses tumour suppressor functions in OAC and is silenced by location-specific promoter DNA methylation. | 23580780 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-375 is downregulated in pancreatic cancer and inhibits cell proliferation in vitro. | 23581226 |
| Malignant Neoplasms, Pancreatic carcinoma | Epigenetic Alterations | Aberrant expression of microRNA-375 (miR-375) has been reported to be involved in development and progression in various types of cancers, but few studies have been conducted to determine its relationship with pancreatic cancer. | 23581226 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) have emerged as important regulators in the development of pancreatic cancer and may be a valuable therapeutic application. | 23581226 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimers disease (AD). | 23582657 |
| Neoplasms | Epigenetic Alterations | MicroRNA miR-378 plays important roles in tumorigenesis by enhancing cell survival, reducing apoptosis, promoting tumor growth, angiogenesis and promoting cell migration and invasion. | 23582927 |
| Pterygium | Epigenetic Alterations | Correlation of microRNA-145 levels and clinical severity of pterygia. | 23583047 |
| Glioblastoma Multiforme | Epigenetic Alterations | Differential expression of MicroRNAs in patients with glioblastoma after concomitant chemoradiotherapy. | 23586679 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are significantly involved in the initiation and progression of numerous cancers; however, the role of miRNAs in recurrence of tumors remains unknown. | 23586679 |
| Cessation of life | Epigenetic Alterations | Bioinformatic analysis revealed that the differentially expressed miRNAs and their putative target genes were mainly involved in cell death, cellular development, and cellular growth and proliferation, which are the key regulators for stem cells. | 23586679 |
| Primary malignant neoplasm | Epigenetic Alterations | Pathway analysis supported that the miRNAs may regulate signaling associated with induction and maintenance of cancer and stem cell, such as p53, ErbB1, Notch, Wnt, and TGF-b signaling pathways. | 23586679 |
| Primary malignant neoplasm | Epigenetic Alterations | These data suggest that, in recurrent GBM, growth factor and anti-apoptotic signalings for cancer cell growth and proliferation are regulated by miRNAs. | 23586679 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Upregulation of microRNA-155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin-1 expression. | 23588589 |
| Addisons disease due to autoimmunity | Epigenetic Alterations | MicroRNA expressions in PMBCs, CD4+, and CD8+ T-cells from patients suffering from autoimmune Addisons disease. | 23589231 |
| Addisons disease due to autoimmunity | Epigenetic Alterations | They extend our very limited knowledge concerning miRNAs in autoimmune Addisons disease. | 23589231 |
| Bacterial Infections | Epigenetic Alterations | The pro-apoptotic miRNA, MIR-15 and MIR-16, were upregulated in cirrhotics with bacterial infections. | 23590253 |
| Small cell carcinoma of lung | Epigenetic Alterations | DNA methylation-mediated repression of miR-886-3p predicts poor outcome of human small cell lung cancer. | 23592755 |
| Small cell carcinoma of lung | Epigenetic Alterations | In this report, we surveyed 924 miRNA (miR) for their expressions in the formalin-fixed paraffin-embedded specimens from 42 patients with SCLC, and found that the downregulated miR-886-3p is closely correlated with the shorter survival of SCLC. | 23592755 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | We therefore characterized the epigenetic makeup of 13q14.3 in CLL cells and found histone modifications by chromatin-immunoprecipitation (ChIP) that are associated with activated transcription and significant DNA-demethylation at the transcriptional start sites of DLEU1 and DLEU2 using 5 different semi-quantitative and quantitative methods (aPRIMES, BioCOBRA, MCIp, MassARRAY, and bisulfite sequencing). | 23593011 |
| Childhood Leukemia | Epigenetic Alterations | Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. | 23593011 |
| Neoplasms | Epigenetic Alterations | While no point mutations have been found in the protein coding candidate genes at 13q14.3, they are deregulated in malignant cells, suggesting an epigenetic tumor suppressor mechanism. | 23593011 |
| Neoplasms | Epigenetic Alterations | These epigenetic aberrations were correlated with transcriptional deregulation of the neighboring candidate tumor suppressor genes, suggesting a coregulation in cis of this gene cluster. | 23593011 |
| Neoplasms | Epigenetic Alterations | Therefore, the tumor suppressor mechanism in 13q14.3 underlines the role both of epigenetic aberrations and of lncRNA genes in human tumorigenesis and is an example of colocalization of a functionally related gene cluster. | 23593011 |
| Anemia, Sickle Cell | Epigenetic Alterations | Expression of regulatory platelet microRNAs in patients with sickle cell disease. | 23593351 |
| Anemia, Sickle Cell | Epigenetic Alterations | We have identified significant differences in functionally active platelet miRNAs in patients with SCD as compared to controls. | 23593351 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant expression of microRNA-34a (miR-34a) has been reported to be involved in the tumorigenesis and progression of various classes of malignancies. | 23593387 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | In conclusion, miR-34a may act as a tumor suppressor miRNA of HCC. | 23593387 |
| Malignant tumor of colon | Epigenetic Alterations | We discovered CCAT1, a non-coding RNA over-expressed in colon cancer (CC), but not in normal tissues, thereby making it a potential disease-specific biomarker. | 23594791 |
| Ulcerative Colitis | Epigenetic Alterations | MicroRNA (miRNA) plays an important role in the pathogenesis of UC by regulating the gene expression at the post-transcriptional level and control crucial physiological processes. | 23595390 |
| Ulcerative Colitis | Epigenetic Alterations | Aquaporin 8 expression is reduced and regulated by microRNAs in patients with ulcerative colitis. | 23595390 |
| Ulcerative Colitis | Epigenetic Alterations | AQP8 and its relationship with miRNAs may be involved in the pathogenesis of UC. | 23595390 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Epigenetic, genetic and environmental interactions in esophageal squamous cell carcinoma from northeast India. | 23596512 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Esophageal squamous cell carcinoma (ESCC) develops as a result of complex epigenetic, genetic and environmental interactions. | 23596512 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Epigenetic changes like, promoter hypermethylation of multiple tumour suppressor genes are frequent events in cancer, and certain habit-related carcinogens are thought to be capable of inducing aberrant methylation. | 23596512 |
| Carcinogenesis | Epigenetic Alterations | DNA methylation, a regulator of gene expression, plays an important role in diverse biological processes including developmental process, carcinogenesis and aging. | 23599224 |
| Malignant Neoplasms | Epigenetic Alterations | In particular, aberrant DNA methylation has been largely observed in several types of cancers. | 23599224 |
| Italy | Epigenetic Alterations | These results pose a major public health problem, as the epigenetic contribution to these changes, rather than longevity, have serious implications indicating earlier onset of neurological morbidity pressurizing families, health and social care services, with resource implications especially for Australia, Canada, Italy, Netherlands, Spain, the UK and the USA. | 23601790 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNAs are a class of small noncoding RNAs playing a crucial role in physiological and pathological conditions, including acute myeloid leukemia. | 23602072 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Patient-specific microRNA expression profiles as a marker for minimal residual disease in acute myeloid leukemia. | 23602072 |
| Malignant Neoplasms, Malignant neoplasm of thyroid | Epigenetic Alterations | MicroRNA (miRNA) expression is deregulated in many types of human cancers, including thyroid cancer. | 23609190 |
| Metastasis | Epigenetic Alterations | The miRNA microarray results showed that compared to the NLN group, upregulation of four miRNAs including miR-2861, miR-451, miR-193b, and miR-1202 was associated with LN metastasis, whereas four other miRNAs including miR-let-7i, miR-542-5p, miR-664*, and miR-564 were downregulated in the LN group. | 23609190 |
| Metastasis, F9 gene | Epigenetic Alterations | Upregulated expression of miR-2861 and miR-451 in PTC with LN metastasis represents a unique miRNA signature associated with the prognosis and progression of PTC. | 23609190 |
| Stomach Carcinoma | Epigenetic Alterations | [Expression of microRNA-100 in human gastric cancer]. | 23611267 |
| Gastrointestinal Stromal Sarcoma | Epigenetic Alterations | [Screening of differentially expressed microRNAs in borderline and malignant gastrointestinal stromal tumors]. | 23611268 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | The most significantly expressed 4 miRNAs were then chosen for further validation by real-time PCR in 22 additional GIST samples. | 23611268 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Among differentially expressed miRNAs, miR-221 and miR-675(*) might be related to the malignant transformation of GISTs, and have a potential value in predicting biological behavior of GISTs. | 23611268 |
| Septicemia | Epigenetic Alterations | Characterization and Identification of novel serum microRNAs in sepsis patients with different outcomes. | 23612084 |
| Septicemia | Epigenetic Alterations | Circulating microRNAs (miRNAs) are an emerging biomarker for sepsis patients. | 23612084 |
| Septicemia | Epigenetic Alterations | In conclusion, 41 novel miRNAs were detectable in the sera of sepsis patients, and six of them might be related to sepsis outcome. | 23612084 |
| Prostate Cancer Pathway | Epigenetic Alterations | MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer. | 23612742 |
| Metastasis, Neoplasms | Epigenetic Alterations | Decreased expression of the microRNA miR-205 has been observed in multiple tumour types due to its role in the epithelial to mesenchymal transition, which promotes metastasis. | 23612742 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Diagnostic and biological significance of microRNA-192 in pancreatic ductal adenocarcinoma. | 23612862 |
| Clinical Observations Supplemental Qualifiers Dataset | Epigenetic Alterations | To date, no information on microRNA (miRNA) expression in pPCL has been reported. | 23613318 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Biological and clinical relevance of miRNA expression signatures in primary plasma cell leukemia. | 23613318 |
| Clinical Observations Supplemental Qualifiers Dataset | Epigenetic Alterations | Global miRNA expression profiles were analyzed in highly purified malignant plasma cells from 18 pPCL untreated patients included in a prospective clinical trial. | 23613318 |
| Multiple Myeloma, Clinical Observations Supplemental Qualifiers Dataset | Epigenetic Alterations | MiRNA expression was also integrated with gene expression profiles in pPCL and multiple myeloma samples. | 23613318 |
| Multiple Myeloma, Clinical Observations Supplemental Qualifiers Dataset | Epigenetic Alterations | We identified a series of deregulated miRNAs in pPCL (42 upregulated and 41 downregulated) in comparison with multiple myeloma. | 23613318 |
| Clinical Observations Supplemental Qualifiers Dataset | Epigenetic Alterations | Overall, our study provides insights into the possible contribution of miRNAs in the pathogenesis of pPCL and suggests targets for future therapeutic investigations. | 23613318 |
| Stomach Carcinoma | Epigenetic Alterations | Gastric cancer is a biologically heterogeneous disease containing many genetic and epigenetic alterations. | 23613399 |
| Ischemic stroke | Epigenetic Alterations | We observed that microRNA-424 (miR-424) significantly decreased in an miRNA profile of circulating lymphocytes of patients with ischemic stroke. | 23613494 |
| Cerebral Ischemia | Epigenetic Alterations | MiRNA-424 protects against permanent focal cerebral ischemia injury in mice involving suppressing microglia activation. | 23613494 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network. | 23620406 |
| Neoplasms, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Long non-coding RNA GAS5 functions as a tumor suppressor in renal cell carcinoma. | 23621190 |
| Cholangiocarcinoma, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-21 regulates the invasion and metastasis in cholangiocarcinoma and may be a potential biomarker for cancer prognosis. | 23621247 |
| Metastasis, Cholangiocarcinoma | Epigenetic Alterations | Influence on cholangiocarcinoma cell line invasion and metastasis was analyzed with microRNA-21 transfected cells. | 23621247 |
| Metastasis | Epigenetic Alterations | In situ hybridization and real-time quantitative PCR results for patients with lymph node metastasis or perineural invasion showed significantly high expression of microRNA-21 (P<0.05). | 23621247 |
| Metastasis, Cholangiocarcinoma | Epigenetic Alterations | There was a dramatic decrease in cholangiocarcinoma cell line invasion and metastasis ability after microRNA-21 knockdown (P<0.05). | 23621247 |
| Metastasis, Cholangiocarcinoma | Epigenetic Alterations | MicroRNA-21 may play an important role in cholangiocarcinoma invasion and metastasis, suggesting that MicroRNA-21 should be further evaluated as a biomarker for predicting cholangiocarcinoma prognosis. | 23621247 |
| Lupus Erythematosus | Epigenetic Alterations | Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients. | 23623029 |
| Lupus Erythematosus | Epigenetic Alterations | Abnormal T cell DNA methylation and type-I interferon play an important role in the pathogenesis of lupus. | 23623029 |
| Lupus Erythematosus | Epigenetic Alterations | DNA methylation was quantified for over 485,000 methylation sites across the genome, and differentially methylated sites between lupus patients and controls were identified and then independently replicated. | 23623029 |
| Abnormal cell, Lupus Erythematosus | Epigenetic Alterations | Our data suggest epigenetic "poising" of interferon-regulated genes in lupus naive CD4+ T cells, argue for a novel pathogenic implication for abnormal T cell DNA methylation in lupus, and suggest a mechanism for type-I interferon hyper-responsiveness in lupus T cells. | 23623029 |
| Lupus Erythematosus | Epigenetic Alterations | We observed significant hypomethylation in interferon-regulated genes in naive CD4+ T cells from lupus patients, including IFIT1, IFIT3, MX1, STAT1, IFI44L, USP18, TRIM22 and BST2, suggesting epigenetic transcriptional accessibility in these genetic loci. | 23623029 |
| Neoplasms, Glioblastoma Multiforme | Epigenetic Alterations | Glioblastoma is one of the most common, lethal and poor clinical outcome primary brain tumors with extraordinarily miscellaneous epigenetic alterations profile. | 23624749 |
| Glioblastoma Multiforme | Epigenetic Alterations | This study of new epigenetic targets has shown considerably high level of analyzed genes promoter methylation variability in glioblastoma tissue. | 23624749 |
| Neoplasms | Epigenetic Alterations | The up-regulated miRNAs (miR-320a, 22 and 129-5p) and down-regulated miRNAs (miR-9, 155 and 640) were confirmed in paclitaxel-resistant FFPE tumor samples, compared with paclitaxel-sensitive samples. | 23627607 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant expression of miRNAs has emerged as an important hallmark of cancer. | 23627613 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Emerging evidence suggests that down-regulated miRNAs play an important role in the carcinogenesis of colorectal cancer (CRC). | 23628392 |
| Clinical Coordinator | Epigenetic Alterations | Single nucleotide polymorphisms (SNPs) in the promoter region of miRNAs may disturb miRNAs processing, alter their expression, and ultimately affect an individuals susceptibility to CRC. | 23628392 |
| cervical cancer | Epigenetic Alterations | Upregulation of microRNA-224 is associated with aggressive progression and poor prognosis in human cervical cancer. | 23631806 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Accumulating evidence for differential expression of microRNA-224 (miR-224) in various types of human cancer suggests that it may be play a crucial role in tumor biology. | 23631806 |
| cervical cancer | Epigenetic Alterations | The previous microarray detection also shown that miR-224 was one of miRNAs with significant upregulation in cervical cancer tissues relative to adjacent normal tissues. | 23631806 |
| Malignant Neoplasms | Epigenetic Alterations | Enhancer of zeste homologue 2 (EZH2) plays important roles in epigenetic silencing and cell cycle regulation and is upregulated in a wide variety of malignancies. | 23636867 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation. | 23637748 |
| Primary malignant neoplasm | Epigenetic Alterations | By methylation-specific PCR, DNA methylation in the upstream region of miR-219-2-3p was detected in both adjacent normal tissues and cancer tissues. | 23637748 |
| SERPINB3 wt Allele | Epigenetic Alterations | The genetic and epigenetic alterations of Epidermal Growth Factor Receptor (EGFR)-RAS-RAF signaling in penile SCC are unclear. | 23637996 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer. | 23640607 |
| Prostate Cancer Pathway, Prostate | Epigenetic Alterations | Prostate cancer-associated ncRNA transcripts 1 (PCAT-1), a lncRNA, has been recently revealed involving in human prostate cancer progression. | 23640607 |
| Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (lncRNA) are emerging as key molecules in human cancer. | 23640607 |
| Mantle cell lymphoma | Epigenetic Alterations | microRNA expression profiles identify subtypes of mantle cell lymphoma with different clinicobiological characteristics. | 23640973 |
| Medial collateral ligament | Epigenetic Alterations | Enriched targets of these miRNAs corresponded to relevant pathways in MCL pathogenesis such as DNA stress response, CD40 signaling, and chromatin modification. | 23640973 |
| Acute myocardial infarction, Angina Pectoris | Epigenetic Alterations | Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris. | 23641832 |
| Malignant tumor of colon | Epigenetic Alterations | A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. | 23642368 |
| Malignant tumor of colon, Neoplasms | Epigenetic Alterations | Here, we show that the tumor suppressor microRNA miR-34a is a cell-fate determinant in early-stage dividing colon cancer stem cells (CCSCs). | 23642368 |
| Prostate Cancer Pathway, CTBP1-AS gene | Epigenetic Alterations | Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer. | 23644382 |
| CTBP1-AS gene | Epigenetic Alterations | Here, we report an androgen-responsive long ncRNA, CTBP1-AS, located in the AS region of C-terminal binding protein 1 (CTBP1), which is a corepressor for androgen receptor. | 23644382 |
| Stomach Carcinoma | Epigenetic Alterations | Decreased expression of long noncoding RNA AC096655.1-002 in gastric cancer and its clinical significance. | 23645148 |
| Liver carcinoma, Hollings Cancer Center, Neoplasm Metastasis | Epigenetic Alterations | We previously reported that miR-185 is associated with hepatocellular carcinoma (HCC) venous metastasis analysed by miRNA-array profile. | 23648054 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients. | 23650424 |
| Transitional cell carcinoma of bladder, UBC gene | Epigenetic Alterations | Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological, genetic, and epigenetic levels. | 23650517 |
| Autoimmune Diseases | Epigenetic Alterations | Modification of the expression of specific microRNAs (miRNAs) has been associated with different autoimmune diseases and/or LPDs. | 23650540 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-424-5p suppresses the expression of SOCS6 in pancreatic cancer. | 23653113 |
| Malignant Neoplasms, Pancreatic carcinoma | Epigenetic Alterations | The expression of microRNA-424-5p (miR-424-5p) has been shown to vary in multiple hematological and solid organ malignancies, such as pancreatic cancer. | 23653113 |
| Chronic heart failure | Epigenetic Alterations | MicroRNAs (miRNAs) are widely involved in the process of chronic heart failure (HF), which is characterized by reactivation of the fetal gene program. | 23660476 |
| Gallbladder Carcinoma, Aggressive behavior | Epigenetic Alterations | High expression of microRNA-155 is associated with the aggressive malignant behavior of gallbladder carcinoma. | 23660842 |
| VHL protein, human, Neurofibromatosis 1, Oncogene, RET, Neoplasms | Epigenetic Alterations | Through characterization of miRNA profiles in 69 frozen tumors with germline mutations in the genes SDHD, SDHB, VHL, RET, NF1, TMEM127, and MAX, we identified miRNA signatures specific to, as well as common among, the genetic groups of PCCs/PGLs. | 23660872 |
| Primary malignant neoplasm | Epigenetic Alterations | Since methylation of tumor-derived DNA can be detected in the serum of cancer patients, this makes DNA methylation-based biomarkers one of the most promising diagnostic strategies. | 23661397 |
| Admitting diagnosis, Traumatic, "Alzheimers Disease", Traumatic Brain Injury | Epigenetic Alterations | Traumatic brain injury (TBI) is an epigenetic risk factor for Alzheimers disease (AD) and amyloid b (Ab) deposition is observed histopathologically in the traumatized brain. | 23662609 |
| Multiple Myeloma | Epigenetic Alterations | [Expression level of microRNA-92a and its clinical significance in multiple myeloma patients]. | 23668207 |
| Adrenocortical carcinoma | Epigenetic Alterations | Deregulation of microRNA (miRNA) expression in adrenocortical carcinomas (ACCs) has been documented to have diagnostic, prognostic, as well as functional implications. | 23671264 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is an important epigenetic modification and is frequently altered in cancer. | 23671639 |
| Metastasis, Ascites | Epigenetic Alterations | A significant up-regulation of miRNA-21 and miRNA-214 was observed in malignant cells of ascites compared to omental metastasis; this was confirmed by both cell viability assay and RT-q-PCR. | 23672416 |
| Metastasis, Neoplasms, Ascites | Epigenetic Alterations | Ours is the first report that demonstrates significant up-regulation of miRNA-21 and miRNA-214 in tumor cells from ascites of patients with EOC compared to omental metastasis. | 23672416 |
| Resistance Process, ovarian neoplasm | Epigenetic Alterations | Chemoresistance in ovarian cancer linked to expression of microRNAs. | 23672416 |
| Colorectal Cancer Pathway | Epigenetic Alterations | microRNA expression profile in stage III colorectal cancer: circulating miR-18a and miR-29a as promising biomarkers. | 23673725 |
| Primary malignant neoplasm | Epigenetic Alterations | The deregulation of miRNA expression has been found in several types of cancer and may represent a novel class of cancer biomarkers. | 23673725 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Our aim was to determine the miRNA signature of stage III colorectal cancer (CRC) tumors and to identify potential circulating miRNAs that may represent non-invasive biomarkers in CRC patients. | 23673725 |
| Clinical Coordinator | Epigenetic Alterations | A selection of differentially overexpressed miRNAs was validated by quantitative real-time polymerase chain reaction (qRT-PCR) and determined in the serum of a set of 56 individuals (30 stage III CRC patients and 26 healthy individuals). | 23673725 |
| Clinical Coordinator | Epigenetic Alterations | We were able to detect 9 of these 11 miRNAs in serum samples from CRC patients and healthy individuals. | 23673725 |
| Clinical Coordinator | Epigenetic Alterations | Moreover, the findings provide relevant information concerning overexpressed tumoral miRNAs as potential circulating biomarkers and highlight serum miR-18a and miR-29a as promising biomarkers for the screening and monitoring of CRC patients. | 23673725 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation of tumor-suppressor genes occurs early in the molecular transformation of precursor events to breast cancer and is therefore of interest to screening in high-risk women. | 23674191 |
| Primary malignant neoplasm | Epigenetic Alterations | The frequency of target gene DNA methylation in tissue and DL of cancer and healthy control patients was assessed, and an association of DNA methylation between different duct systems in the same breast was explored. | 23674191 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Tumor, adjacent tissue and bilateral DL samples for comparative DNA methylation studies were obtained during surgery from women with cancer. | 23674191 |
| SCGB3A1 gene, Primary malignant neoplasm | Epigenetic Alterations | The sensitivity of DNA methylation in DL samples compared with matched cancer tissue was highest for SCGB3A1 (90 %), CDH13 (91 %), and RARB (83 %). | 23674191 |
| Primary malignant neoplasm | Epigenetic Alterations | The genetic algorithm selected RASSF1A, RARB, and IGFBP7 as the optimum predictor set for detecting DNA methylation in cancer tissue. | 23674191 |
| Primary malignant neoplasm | Epigenetic Alterations | The optimum area under the ROC curve for DNA methylation in cancer compared with internal control healthy tissue from excision margins was 0.84. | 23674191 |
| Primary malignant neoplasm | Epigenetic Alterations | The area under the ROC curve for DNA methylation in cancer DL compared with contralateral benign DL was 0.76. | 23674191 |
| Breast Carcinoma | Epigenetic Alterations | The approach of DNA methylation in DL may be substantiated by a larger trial of breast cancer biomarkers. | 23674191 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Protein-coding genes and long noncoding RNAs are differentially expressed in dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib. | 23676950 |
| Esophageal carcinoma | Epigenetic Alterations | We report the emerging role of microRNA (miRNA) deregulation associated with activation of an oncogene SOX4 (a member of the SRY-related HMG-box) in esophageal carcinoma. | 23677061 |
| Primary malignant neoplasm | Epigenetic Alterations | Restoration of miR-129-2 by transfection with an miRNA expression plasmid led to a decrease in SOX4 expression, which was accompanied by reduced migration and proliferation of the cancer cells. | 23677061 |
| Esophageal carcinoma | Epigenetic Alterations | Our results demonstrated that the deregulation of miR-129-2 leads to aberrant SOX4 expression, presenting a new paradigm in which the restoration of miRNA suppresses its oncogenic target in esophageal cancer. | 23677061 |
| Metastasis, Neoplasms | Epigenetic Alterations | The discovery that microRNAs (miRNAs) regulate proliferation, invasion and metastasis provides a principal molecular basis of tumor heterogeneity. | 23679262 |
| Neoplasms | Epigenetic Alterations | MiRNAs can regulate gene expression, cell growth, differentiation and apoptosis by targeting mRNAs for translational repression or degradation in tumor cells. | 23679328 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation at CpG islands within promoters is increasingly recognised as a common event in human cancers and has been associated with the silencing of important tumour suppressor genes. | 23679560 |
| SF3B1 wt Allele | Epigenetic Alterations | Epigenetic therapy using hypomethylating agents has demonstrated clinical effectiveness; the drugs azacitidine and decitabine have been approved for the treatment of MDS. | 23679560 |
| Malignant neoplasm of urinary bladder, Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Bladder cancer like other cancers arises from the accumulation of many genetic and epigenetic changes that lead to the activation of proto-oncogenes or inactivation of tumor suppressor genes. | 23682613 |
| Neoplasms, Hereditary | Epigenetic Alterations | No significant differences in miRNA expression were found between RET mutation positive and negative tumors nor between sporadic and hereditary tumors. | 23685355 |
| Neoplasms | Epigenetic Alterations | MicroRNAs are a primordial mechanism of gene expression control that appear to be crucial to cellular development and may play an important role in tumor development. | 23685355 |
| Carcinoma of lung | Epigenetic Alterations | In human (HOP62, H522, and H23) and murine transgenic (ED-1, ED-2, LKR-13, and 393P, driven, respectively, by cyclin E, degradation-resistant cyclin E, KRAS, or KRAS/p53) lung cancer cell lines, vorinostat reduced growth, cyclin D1, and cyclin E levels, but induced p27, histone acetylation, and apoptosis. | 23686769 |
| Chronic active Epstein-Barr virus infection | Epigenetic Alterations | Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection. | 23687223 |
| Epstein-Barr Virus Infections | Epigenetic Alterations | Levels of specific plasma EBV miRNAs were elevated differentially in patients with CAEBV infection. | 23687223 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miRNA) deregulation is associated with progression and treatment outcome in various types of cancers. | 23689423 |
| Leukemia, Myelomonocytic, Chronic, JAK2 protein, human, nucleophosmin, NRAS gene, KRAS protein, human | Epigenetic Alterations | We genotyped ASXL1 and up to 18 other genes including epigenetic (TET2, EZH2, IDH1, IDH2, DNMT3A), splicing (SF3B1, SRSF2, ZRSF2, U2AF1), transcription (RUNX1, NPM1, TP53), and signaling (NRAS, KRAS, CBL, JAK2, FLT3) regulators in 312 patients with CMML. | 23690417 |
| Clinical Coordinator | Epigenetic Alterations | MiRNAs were profiled by TaqMan MicroRNA Array and screened for differential expression in 5 pools of plasma samples of CRC patients (N = 50) and 5 pools of neoplasm-free controls (N = 50). | 23690963 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Identification and evaluation of plasma microRNAs for early detection of colorectal cancer. | 23690963 |
| Clinical Coordinator | Epigenetic Alterations | Circulating microRNAs (miRNAs) have been suggested as potentially promising markers for early detection of CRC. | 23690963 |
| Clinical Coordinator | Epigenetic Alterations | Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples. | 23690963 |
| Adenoma | Epigenetic Alterations | None of the selected miRNAs showed significant differential expression between advanced adenoma patients and neoplasm-free controls. | 23690963 |
| Clinical Coordinator | Epigenetic Alterations | The identified panel of miRNAs could be of potential use in the development of a multi-marker blood based test for early detection of CRC. | 23690963 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer. | 23694962 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer (CRC) and precursor lesions have been extensively studied. | 23694962 |
| Neoplastic disease, Inflammatory Bowel Diseases | Epigenetic Alterations | Moreover, our panel may complement histologic and endoscopic diagnosis of inflammatory bowel disease (IBD)-associated neoplasia, as it was also efficient detecting aberrant DNA methylation in non-neoplastic tissue samples from affected patients. | 23694962 |
| Breast Carcinoma | Epigenetic Alterations | Decreased expression of microRNA-206 in breast cancer and its association with disease characteristics and patient survival. | 23696595 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-206 (miR-206) is downregulated in many human malignancies, which correlates with tumour progression. | 23696595 |
| Heart failure | Epigenetic Alterations | Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients. | 23696613 |
| Cardiovascular Diseases | Epigenetic Alterations | Since their identification in the circulation, microRNAs have received considerable interest as putative biomarkers of cardiovascular disease. | 23696613 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Seventeen microRNAs were selected for validation in 44 HF, 32 COPD, 59 other breathless, and 15 controls. | 23696613 |
| Neoplasms | Epigenetic Alterations | Epigenetic events, including covalent post-translational modifications of histones, have been demonstrated to have critical roles in tumor development and progression. | 23698071 |
| Sample Size Calculation | Epigenetic Alterations | Aberrant epigenetic modifications also contribute to the persistent activation of SSc fibroblasts. | 23698475 |
| Sample Size Calculation | Epigenetic Alterations | We investigated whether increased Wnt signalling and epigenetic changes in SSc are causally linked via promoter hypermethylation-induced silencing of Wnt antagonists. | 23698475 |
| Sample Size Calculation | Epigenetic Alterations | These data provide a novel link between epigenetic alterations and increased Wnt signalling in SSc and also have translational implications because Dnmt inhibitors are already approved for clinical use. | 23698475 |
| Neoplasms | Epigenetic Alterations | Combining DNA methylation and gene expression data led to the identification of the epigenetically regulated tumor modulating genes GPX3, RBP1, SPARC, and TGFBI. | 23699600 |
| Multiple Myeloma | Epigenetic Alterations | Assessment of the DNA methylation status of the identified genes could contribute to the molecular characterization of myeloma, which is prerequisite for an individualized treatment approach. | 23699600 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | These observations suggest that ARID1A is a causative gene, instead of a target gene, of microsatellite instability by having a role in epigenetic silencing of the MLH1 gene in endometrial cancer. | 23702729 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Results from the present explorative study suggest that quantitative epigenetic classification of rectal cancer by MS-MLPA clearly distinguishes tumor tissue from apparently normal mucosa. | 23702823 |
| Clinical Coordinator, Adenoma | Epigenetic Alterations | We validated expression of candidate miRNAs in serum samples from an independent cohort of 186 CRC patients, 60 postoperative patients, 43 advanced adenoma patients, and 53 control subjects. | 23704278 |
| Clinical Coordinator | Epigenetic Alterations | We analyzed miR-21 expression in 166 matched primary CRC tissues to determine whether serum miRNAs reflect expression in CRC. | 23704278 |
| Neurodegenerative Disorders, Antilymphocyte Serum | Epigenetic Alterations | Considering that miRNAs are increasingly being recognized as having a role in a variety of neurodegenerative diseases, we decided to characterize the miRNA expression profile in spinal cord (SC) tissue in sporadic ALS (sALS) and controls. | 23705811 |
| Cerebrovascular accident, Impaired cognition, nervous system disorder | Epigenetic Alterations | European Leukodystrophies Association, INSERM and Assistance Publique-Hopitaux de Paris, Dutch Organisation for Scientific Research (ZonMw), E-Rare, Hersenstichting, Optimix Foundation for Scientific Research, Myelin Disorders Bioregistry Project, National Institute of Neurological Disorders and Stroke, and Genetic and Epigenetic Networks in Cognitive Dysfunction (GENCODYS) Project (funded by the European Union Framework Programme 7). | 23707145 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Epigenetic silencing was particularly severe in SDHB-mutated tumors, potentially explaining their malignancy. | 23707781 |
| Heart failure, Coronary Artery Disease | Epigenetic Alterations | Coronary artery disease (CAD)-associated ischemic heart failure is characterized by dysregulated gene expression which is partly mediated by microRNAs (miRNAs). | 23711953 |
| Pancreatic carcinoma | Epigenetic Alterations | The regulation of Mut L homologue 1 (MLH1) expression by microRNA (miR)-155 and its prognostic significance in pancreatic cancer (PC) remain to be elucidated. | 23715647 |
| Kidney Failure, Acute | Epigenetic Alterations | MicroRNA-21 and risk of severe acute kidney injury and poor outcomes after adult cardiac surgery. | 23717419 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST]. | 23717541 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | A cluster of miRNAs on 14q32 show strikingly different expression patterns amongst GISTs, a finding which appears to be explained at least in part by differential allelic methylation of this imprinted region. | 23717541 |
| Bladder Neoplasm | Epigenetic Alterations | Also, our results suggest interesting differentially regulated miRNA-mRNA interactions associated with bladder tumor progression. | 23717626 |
| Primary malignant neoplasm | Epigenetic Alterations | It has been proposed that miRNAs play an important role in cancer development and progression. | 23717626 |
| Primary malignant neoplasm | Epigenetic Alterations | Further analysis reveals genes identified as differentially regulated by miRNAs to be enriched in cancer pathways, thus suggesting biologically interesting interactions. | 23717626 |
| Chronic Kidney Diseases | Epigenetic Alterations | Decreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD). | 23717629 |
| Chronic Kidney Diseases | Epigenetic Alterations | In conclusion, we have found ex vivo and in vitro evidence for decreased expression of these vascular miRNA in CKD, suggesting that alterations in miRNAs may lead to the synthetic state of VSMC found in CKD. | 23717629 |
| Vascular smooth muscle cell | Epigenetic Alterations | MicroRNAs (miRNAs) control mRNA expression intracellularly and are secreted into the circulation; three miRNAs (miR-125b, miR-145 and miR-155) are known to alter vascular smooth muscle cell (VSMC) proliferation and differentiation. | 23717629 |
| Multiple Myeloma | Epigenetic Alterations | Improved risk stratification in myeloma using a microRNA-based classifier. | 23718138 |
| Colorectal Carcinoma | Epigenetic Alterations | MicroRNAs (miRNA) have potential prognostic value for colorectal cancers; however, their value based on patient race/ethnicity and pathologic stage has not been determined. | 23719259 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The prognostic value of microRNAs varies with patient race/ethnicity and stage of colorectal cancer. | 23719259 |
| African American | Epigenetic Alterations | The goal was to ascertain the prognostic value of 5 miRNAs with increased expression in colorectal cancers of African American (black) and non-Hispanic Caucasian (white) patients. | 23719259 |
| Colorectal Carcinoma | Epigenetic Alterations | All 5 miRNAs had higher expression in colorectal cancers (>1.0-fold) than in corresponding normal tissues. | 23719259 |
| Colorectal Carcinoma | Epigenetic Alterations | These preliminary findings suggest that the prognostic value of miRNAs in colorectal cancers varies with patient race/ethnicity and stage of disease. | 23719259 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA gene polymorphisms in pancreatic cancer. | 23719600 |
| Pancreatic Neoplasm | Epigenetic Alterations | Our findings suggested that the rs2910164 and rs11614913 SNPs might play a role in pancreatic tumorigenesis, but the molecular mechanism underlying the particular sequence variations in miRNA that can cause aberrant expression remains to be determined. | 23719600 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | These findings suggest that the relative low expression of miRNA-34a might be involved in the tumorigenesis of bladder cancer. | 23720881 |
| HIV | Epigenetic Alterations | MicroRNA regulation and its effects on cellular transcriptome in human immunodeficiency virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts. | 23721325 |
| Communicable Diseases | Epigenetic Alterations | Selected miRNA and mRNA transcripts were validated using in vivo and in vitro infection model. | 23721325 |
| Neoplasms, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Epigenetic alterations of Kruppel-like factor 4 and its tumor suppressor function in renal cell carcinoma. | 23722653 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | The purpose of this study is to determine epigenetic alterations and possible roles of KLF4 in renal cell carcinoma. | 23722653 |
| Malignant Neoplasms, MIR20A gene | Epigenetic Alterations | MicroRNA- 20a (miR-20a) and microRNA-203 (miR-203) have previously shown significant alteration in a range of cancers. | 23725129 |
| cervical cancer | Epigenetic Alterations | We propose that miRNAs might be used as therapeutic agents for cervical cancer. | 23725129 |
| Hodgkin Disease | Epigenetic Alterations | MicroRNA signatures and treatment response in patients with advanced classical Hodgkin lymphoma. | 23725219 |
| Hodgkin Disease | Epigenetic Alterations | Although specific microRNA (miRNA) signatures in classical Hodgkin lymphoma (cHL) have been proposed, their relationship with clinical outcome remains unclear. | 23725219 |
| MIR21 gene, doxorubicin | Epigenetic Alterations | Additionally, functional silencing of MIR21 and MIR30D in L428 cells showed increased sensitivity to doxorubicin-induced apoptosis, pointing towards abnormalities of mitochondrial intrinsic and TP53-CDKN1A pathways as related to miRNA deregulation in cHL. | 23725219 |
| Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | Serum levels of miRNAs, miR-21, miR-34a, miR-122, and miR-451 were higher in participants with NAFLD. | 23727030 |
| Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | Serum levels of miRNAs, particularly miR-122, may be a useful biomarker for NAFLD. | 23727030 |
| Endometrial Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | We analyzed more than 27,000 CpGs in normal endometrial tissue (n = 23) and endometrial cancers (n = 64) and found that DNA methylation of GALR1 is among the most frequent epigenetic alterations in this cancer. | 23727823 |
| Malignant Neoplasms, Malignant neoplasm of endometrium, Postmenopausal bleeding | Epigenetic Alterations | The receiver operating characteristics area under the curve, describing sensitivity and specificity to correctly identify the 41 women with both premalignant and malignant endometrial changes, was 0.93 (95% confidence interval, 0.87-0.97; P < 0.0001).GALR1 DNA methylation is one of the most common molecular alterations in endometrial cancer, and the presence of GALR1 methylation in vaginal swabs from women with postmenopausal bleeding indicates the presence of endometrial malignancy with a sensitivity of 92.7% and a specificity of 78.9%. | 23727823 |
| Neoplasms | Epigenetic Alterations | We show that ZBTB7A physically interacts with SOX9 and functionally antagonizes its transcriptional activity on key target genes such as MIA, which is involved in tumor cell invasion, and H19, a long noncoding RNA precursor for an RB-targeting microRNA. | 23727861 |
| Malignant neoplasm of larynx | Epigenetic Alterations | Global DNA methylation status in laryngeal cancer. | 23729003 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | MicroRNA-503 suppresses proliferation and cell-cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1. | 23731275 |
| Initiation | Epigenetic Alterations | MicroRNAs (miRNAs) are post-transcriptional inhibitor regulators of gene expression that act by directly binding complementary mRNA and are key determinants of cancer initiation and progression. | 23731275 |
| Stomach Carcinoma | Epigenetic Alterations | MiRNA-199a-3p: A potential circulating diagnostic biomarker for early gastric cancer. | 23733518 |
| Stomach Diseases | Epigenetic Alterations | The expression of miRNA-199a-3p (47.5 +- 6.5) in plasma in EGC patients was significantly higher than that from healthy controls (13.9 +- 2.7, P < 0.001) and gastric precancerous diseases (GPD) patients (19.2 +- 2.5, P = 0.004), respectively. | 23733518 |
| Neoplasms | Epigenetic Alterations | With respect of clinicopathological characteristics, the expression of miRNA-199a-3p in plasma was not associated with the depth of tumor invasion. | 23733518 |
| Neoplasms | Epigenetic Alterations | Moreover, the AUC of the expression of miRNA-199a-3p in plasma for EGC diagnosis was 0.818, which was significantly higher than that of combined tumor markers (0.556). | 23733518 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met. | 23734217 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNA-449a is expressed at a low level in several tumors and cancer cell lines, and induces G1 arrest, apoptosis, and senescence. | 23734217 |
| Ulcerative Colitis | Epigenetic Alterations | Based on these preliminary findings, diagnostic markers based on differential DNA methylation at specific loci can be useful for non-invasive and reliable detection of UC and epigenetic field defect. | 23735005 |
| Hypertrophy, Fibrosis Assessment | Epigenetic Alterations | In responders, reverse remodelling is associated with favourable changes in miRNAs that regulate cardiac fibrosis, apoptosis, and hypertrophy. | 23736534 |
| Neoplasms | Epigenetic Alterations | Epigenetic changes are considered to be a frequent event during tumor development. | 23736679 |
| Malignant neoplasm of endometrium, Carcinogenesis | Epigenetic Alterations | The findings suggest the importance of hypermethylation of CDH13, WT1 and GATA5 genes in endometrial carcinogenesis and could have implications for future diagnostic and therapeutic strategies of endometrial cancer based on epigenetic changes. | 23736679 |
| Primary malignant neoplasm | Epigenetic Alterations | Cancer is a multifactorial disease composed of cells that show somatic mutations and epigenetic changes. | 23738964 |
| Antilymphocyte Serum | Epigenetic Alterations | Therefore, antisense oligonucleotides may be used to successfully inhibit miRNAs throughout the brain and spinal cord, and miR-155 is a promising new therapeutic target for human ALS. | 23740943 |
| Malignant tumor of colon | Epigenetic Alterations | Diagnostic microRNA markers to screen for sporadic human colon cancer in stool: I. | 23741026 |
| Tetranitromethane, Malignant tumor of colon | Epigenetic Alterations | Twelve of the miRNAs exhibited increased and 8 decreased expression in stool from 60 individuals (20 controls, 20 with tumor-lymph node-metastatic (TNM) stage 0-1, 10 with stage 2, five with stage 3, and 5 with stage 4 colon cancer) to quantitatively monitor miRNA changes at various TNM stages of colon cancer progression. | 23741026 |
| Malignant tumor of colon | Epigenetic Alterations | The performance characteristics of the test confirmed that stool is a medium well-suited for colon cancer screening, and that the quantitative changes in the expression of few mature miRNA molecules in stool associated with colon cancer progression provided for more sensitive and specific non-invasive diagnostic markers than tests currently available on the market. | 23741026 |
| Malignant tumor of colon, MIR20A gene, Adenoma, Carcinoma | Epigenetic Alterations | Results of the PCR analyses confirmed that twelve miRNAs (miR-7, miR-17, miR-20a, miR-21, miR-92a, miR-96, miR-106a, miR-134, miR-183, miR-196a, miR-199a-3p and miR214) had an increased expression in the stool of patients with colon cancer, and that later TNM carcinoma stages exhibited a more pronounced expression than did adenomas. | 23741026 |
| Malignant tumor of colon, Tetranitromethane | Epigenetic Alterations | On the other hand, eight miRNAs (miR-9, miR-29b, miR-127-5p, miR-138, miR-143, miR-146a, miR-222 and miR-938) had decreased expression in the stool of patients with colon cancer, which was also more pronounced from early to later TNM stages. | 23741026 |
| Aggressive behavior, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer. | 23743197 |
| Malignant Neoplasms, Metastasis | Epigenetic Alterations | HOTAIR is one of long non-coding RNAs and its expression correlates with the prognosis and metastasis in various cancers. | 23743197 |
| ovarian neoplasm, Neoplasms, Cessation of life | Epigenetic Alterations | Ovarian cancer is the leading cause of death from gynaecologic tumours, but the molecular and especially epigenetic events underlying the transformation are poorly understood. | 23746174 |
| ovarian neoplasm | Epigenetic Alterations | To search for epigenetic events we used methylation-specific multiplex ligation-dependent probe amplification to compare the methylation status of 44 tissue samples of ovarian cancer with 30 control samples. | 23746174 |
| ovarian neoplasm | Epigenetic Alterations | These findings could potentially be used in screening of ovarian cancer, and may have implications for future chemotherapy based on epigenetic changes. | 23746174 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Identification and characterization of microRNAs in vascular smooth muscle cells from patients with abdominal aortic aneurysms. | 23746831 |
| Cardiovascular Diseases | Epigenetic Alterations | The role of microRNAs (miRs) in the development of various cardiovascular diseases was recently highlighted in several studies. | 23746831 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation has shown promise as a biomarker for the early detection of cancer. | 23747112 |
| Hypertrophy | Epigenetic Alterations | Release kinetics of circulating muscle-enriched microRNAs in patients undergoing transcoronary ablation of septal hypertrophy. | 23747779 |
| Cardiovascular Diseases | Epigenetic Alterations | miRNAs may be useful as novel biomarkers in patients with cardiovascular disease, although it is difficult to establish the detailed release kinetics of miRNAs in patients with AMI. | 23747779 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRs) are small, noncoding RNAs that target genes involved in tumor development and progression. | 23748853 |
| Neoplasms | Epigenetic Alterations | Using quantitative TaqMan MicroRNA PCR, we measured the relative concentrations of 6 circulating microRNAs (miR-10b, -17, -34a, -93, -155, and -373) known to be relevant for tumor development and progression. | 23748853 |
| Breast Cancer Cell | Epigenetic Alterations | Deregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression. | 23748853 |
| Breast Carcinoma | Epigenetic Alterations | Our findings indicate that serum concentrations of deregulated microRNAs may be linked to a particular biology of breast carcinomas favoring progression and metastatic spread. | 23748853 |
| Stomach Carcinoma | Epigenetic Alterations | Downregulation of microRNA-206 is a potent prognostic marker for patients with gastric cancer. | 23751352 |
| Breast Carcinoma, Malignant neoplasm of larynx, Neoplasms, Malignant Neoplasms, Carcinoma of lung, Rhabdomyosarcoma, Glioblastoma Multiforme Pathway, Endometrial Endometrioid Adenocarcinoma | Epigenetic Alterations | MicroRNA-206 (miR-206), as a homolog of miR-1, plays important roles in tumorigenesis and tumor progression of various human malignancies, including breast cancer, endometrial endometrioid carcinoma, rhabdomyosarcoma, glioma, lung cancer, and laryngeal cancer. | 23751352 |
| Neoplasms | Epigenetic Alterations | The high relative stability of miRNAs in biofluids such as plasma and serum, and the ability of miRNA expression profiles to accurately classify discrete tissue types and disease states have positioned miRNAs as promising non-invasive new tumor biomarkers. | 23756108 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Deregulation of miRNAs expression levels has been detected in many human tumor types, and recent studies have demonstrated the critical roles of miRNAs in cancer pathogenesis. | 23756108 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We further validated our results by RT-qPCR for differentially expressed miRNAs in an independent group of 40 matched fresh frozen tissues, 37 plasma samples from NSCLC patients and 28 healthy donors. | 23756108 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | However, in NSCLC plasma samples, only three of these miRNAs (miR-21, miR-10a, and miR-30e-5p) displayed differential expression when compared to plasma of healthy donors. | 23756108 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer. | 23758639 |
| Clinical Coordinator | Epigenetic Alterations | The triple miRNA classifier of miR-193a-3p, miR-23a and miR-338-5p appears to be a potential blood biomarker for early detection of CRC. | 23758639 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating blood miRNAs offer great potential as cancer biomarkers. | 23758639 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | The objective of this study was to correlate the differential expression of miRNAs in tissue and blood in the identification of biomarkers for early detection of colorectal cancer (CRC). | 23758639 |
| Immune dysregulation | Epigenetic Alterations | Dysregulations in circulating blood miRNAs are reflective of those in colorectal tissues. | 23758639 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | BCL11A overexpression predicts survival and relapse in non-small cell lung cancer and is modulated by microRNA-30a and gene amplification. | 23758992 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Data from array-based Comparative Genomic Hybridization (aCGH) and microRNA transfection experiments were integrated to explore the potential mechanisms of abnormal BCL11A activation in NSCLC. | 23758992 |
| Adenocarcinoma of lung (disorder), Squamous cell carcinoma of lung | Epigenetic Alterations | Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma. | 23759980 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These newly identified miRNAs may prove to be highly valuable molecular markers for the classification of NSCLC histological subtypes and may contribute to the pathogenesis of each subtype of NSCLC. | 23759980 |
| MIRN548 microRNA, human | Epigenetic Alterations | This resulted in loss of 9 out of 14 miRNA binding sites (hsa-miR-548 family), despite the significant overexpression of miR548a-5p and miR548d-5p among such cases (28.64 and 36.25 folds, respectively), in comparison to HPV negative control samples. | 23762404 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-22 expression in hepatocellular carcinoma and its correlation with ezrin protein. | 23766411 |
| Liver carcinoma, Hollings Cancer Center, Neoplasms | Epigenetic Alterations | Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. | 23766440 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. | 23766440 |
| Endothelial dysfunction | Epigenetic Alterations | MiR-21, a multiple-functional miRNA, was evidenced to be involved in endothelial dysfunction, however, the underlying molecular mechanisms were still unknown. | 23771797 |
| Adenoid Cystic Carcinoma, Neoplasms | Epigenetic Alterations | The expression of some miRNAs differed in the tumor tissues compared to their controls: the let-7b was overexpressed in salivary gland-derived adenoid cystic carcinoma, while decreased in breast-derived adenoid cystic carcinoma. | 23774803 |
| Adenoid Cystic Carcinoma | Epigenetic Alterations | Through post-transcriptional regulation of the genes, the diverse expression of some miRNAs may partially explain the diverse clinical outcome of salivary gland-derived and breast-derived adenoid cystic carcinomas. | 23774803 |
| Colorectal Carcinoma | Epigenetic Alterations | An essential microRNA maturing microprocessor complex component DGCR8 is up-regulated in colorectal carcinomas. | 23775303 |
| Clinical Coordinator, Immune dysregulation, Carcinogenesis, Colorectal Cancer Pathway | Epigenetic Alterations | Dysregulations in the miRNA machinery may be involved in carcinogenesis of colorectal cancer (CRC). | 23775303 |
| Ancriviroc | Epigenetic Alterations | First, we employed Illumina deep sequencing for the initial screening to indicate the read numbers of miRNA expression in 10 PBC, 5 CH-C, 5 CH-B patients and 5 healthy controls. | 23776611 |
| Ancriviroc | Epigenetic Alterations | The heat map and hierarchical clustering demonstrated that the miRNA profiles from PBC clustered with those of CH-B, CH-C and healthy controls. | 23776611 |
| Primary Biliary Cholangitis | Epigenetic Alterations | Distinct microRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers. | 23776611 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Overexpression of miRNA-21 promotes radiation-resistance of non-small cell lung cancer. | 23777591 |
| Primary malignant neoplasm | Epigenetic Alterations | MiRNA-21 was previously reported to be up-regulated in many kinds of cancer. | 23777591 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA-21 expression increased in non-small cell lung cancer. | 23777591 |
| Metastasis | Epigenetic Alterations | Expression of miRNA-21 was positively associated with lymph node metastasis, clinical stage and poor prognosis. | 23777591 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA-21 may be considered as a potential novel target for future development of specific therapeutic interventions in NSCLC. | 23777591 |
| Malignant Neoplasms, Cancer-Related Death | Epigenetic Alterations | Chemo-resistance is one of the key causal factors in cancer death and emerging evidences suggest that microRNAs (miRNAs) have critical roles in the regulation of chemo-sensitivity in cancers. | 23778521 |
| Cessation of life | Epigenetic Alterations | The mucin phenotype and expression of microRNA-21 (miR-21) and programmed cell death protein 4 (PDCD4) were also analysed. | 23778530 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Involvements of microRNA-22 (miR-22) in cancer development have attracted much attention, but its role in tumorigenesis of gastric cancer is still largely unknown. | 23786758 |
| Liver carcinoma | Epigenetic Alterations | Epigenetic silencing of DACH1 induces loss of transforming growth factor-b1 antiproliferative response in human hepatocellular carcinoma. | 23787902 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic mechanisms have important roles in carcinogenesis. | 23788032 |
| Carcinogenesis, Colorectal Cancer Pathway | Epigenetic Alterations | These molecular pathological epidemiology data suggest a protective effect of smoking cessation on a DNA methylation-related carcinogenesis pathway leading to CIMP-high colorectal cancer. | 23788674 |
| FRAGILE X TREMOR/ATAXIA SYNDROME | Epigenetic Alterations | MicroRNA expression profiling in blood from fragile X-associated tremor/ataxia syndrome patients. | 23790110 |
| Neurodegenerative Disorders | Epigenetic Alterations | Since the identification of the first microRNAs (miRNAs) and their role in normal development, several studies have associated them with neurodegenerative diseases such as Parkinson, Alzheimer and Huntington diseases, suggesting that they play a key role in brain development, as well as in its morphogenesis. | 23790110 |
| FRAGILE X TREMOR/ATAXIA SYNDROME | Epigenetic Alterations | When comparing these results, 14 miRNAs were found deregulated in FXTAS patients. | 23790110 |
| Malignant Neoplasms, Breast Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-7 (miR-7) has been described as a tumor suppressor in several human cancers, but the results of a study to identify miRNAs associated with metastatic capability in breast cancer suggested that miR-7 may be characterized as an oncogene. | 23793934 |
| Renal Cell Carcinoma, Refractory Cytopenia of Childhood | Epigenetic Alterations | Quantitative real-time polymerase chain reaction was used to validate the expressions of miR-7 in 48 paired renal cell carcinomas (RCC) and normal tissues, based on the preliminary sequencing results of miRNAs. | 23793934 |
| Breast Carcinoma | Epigenetic Alterations | Identification of circulating microRNA signatures for breast cancer detection. | 23797906 |
| Mammary Neoplasms | Epigenetic Alterations | miRNA from paired breast cancer tumors, normal tissue, and serum samples derived from 32 patients were comprehensively profiled using microarrays or locked nucleic acid real-time PCR panels. | 23797906 |
| Breast Carcinoma, Mammary Neoplasms | Epigenetic Alterations | The 20 most significant miRNAs differentially expressed in breast cancer tumors included miRNA (miR)-21, miR-10b, and miR-145, previously shown to be dysregulated in breast cancer. | 23797906 |
| Malignant neoplasm of breast | Epigenetic Alterations | The clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different subtypes of breast cancers. | 23797906 |
| Neoplasms | Epigenetic Alterations | Only 7 miRNAs were overexpressed in both tumors and serum, suggesting that miRNAs may be released into the serum selectively. | 23797906 |
| Prostate Cancer Pathway | Epigenetic Alterations | Distinct microRNA expression profile in prostate cancer patients with early clinical failure and the impact of let-7 as prognostic marker in high-risk prostate cancer. | 23798998 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our findings define a distinct miRNA expression profile in PCa cases with early CF and identified let-7b as prognostic biomarker in high-risk PCa. | 23798998 |
| CHOANAL ATRESIA, POSTERIOR, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs, being important regulators of gene expression, are promising biomarkers in various cancer entities, though the impact as prognostic predictors in PCa is poorly understood. | 23798998 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Epigenetic Alterations | We identified an miRNA signature of 7 miRNAs (5 upregulated: miR-512-3p, miR-886-5p, miR-886-3p, miR-708, miR-135b; 2 downregulated: miR-146a, miR-155) significantly associated with ALK(+) ALCL cases. | 23801630 |
| Ki-1+ Anaplastic Large Cell Lymphoma, Peripheral T-Cell Lymphoma | Epigenetic Alterations | In addition, we derived an 11-miRNA signature (4 upregulated: miR-210, miR-197, miR-191, miR-512-3p; 7 downregulated: miR-451, miR-146a, miR-22, miR-455-3p, miR-455-5p, miR-143, miR-494) that differentiates ALK(-) ALCL from other PTCLs. | 23801630 |
| Stomach Carcinoma | Epigenetic Alterations | Upregulation of microRNA 181c expression in gastric cancer tissues and plasma. | 23803080 |
| Neoplasms | Epigenetic Alterations | Thus, it is very important to perform microarray-based miRNA screening of tumors at different sites. | 23803104 |
| Triple-Negative Breast Cancer Finding, Neoplasms | Epigenetic Alterations | Seventeen kinds of miRNAs were heterogeneously distributed in the tumors from different clinicopathological subtypes that included 1 kind of miRNA in Luminal A and Luminal B Her2+ subtypes, 4 kinds in Luminal A and Her2 overexpression subtypes, 6 kinds in Luminal B Ki67+ and Luminal B Her2+ subtypes, 2 kinds between Luminal B Ki67+ and triple-negative breast cancer (TNBC) subtypes, 2 kinds between Luminal B Her2+ and TNBC subtypes, and 2 kinds between Luminal B Ki67+, Luminal B Her2+, and TNBC subtypes. | 23803104 |
| Breast Carcinoma | Epigenetic Alterations | Differential distribution of microRNAs in breast cancer grouped by clinicopathological subtypes. | 23803104 |
| Metastasis, Neoplasms | Epigenetic Alterations | microRNAs (miRNAs) that regulate proliferation, invasion and metastasis are considered to be the principal molecular basis of tumor heterogeneity. | 23803104 |
| Neoplasms | Epigenetic Alterations | All differential miRNAs were analyzed between the edges and centers of the tumors. | 23803104 |
| Neoplasms | Epigenetic Alterations | Twenty kinds of miRNAs were homogenously distributed in the tumors from different clinicopathological subtypes that included 6 kinds of miRNAs in Luminal B Ki67+ and Luminal B Her2+ subtypes, 1 kind in Luminal B Ki67+ and Her2 overexpression subtypes, 10 kinds between Luminal B Ki67+ and TNBC subtypes, 2 kinds in Luminal B Her2+ and TNBC subtypes, and 1 kind between Luminal B Ki67+, Luminal B Her2+, and TNBC subtypes. | 23803104 |
| Neoplasms | Epigenetic Alterations | A total of 37 miRNAs were significantly distributed in tumors from the centers to edges, and in all clinicopathological subtypes. | 23803104 |
| B-Cell Lymphomas | Epigenetic Alterations | Finally, treatment with methyl inhibitors induced re-expression of ANGPT2 in two B-cell lymphoma cell lines, underscoring the importance of DNA methylation in regulating transcriptional silencing of this gene. | 23803577 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | In conclusion, we believe that the known variability in ANGPT2 expression among CLL patients could be explained by differential promoter DNA methylation and that low methylation levels of the ANGPT2 promoter have an adverse prognostic impact in CLL. | 23803577 |
| Coronary Artery Disease | Epigenetic Alterations | Impact of intravenous heparin on quantification of circulating microRNAs in patients with coronary artery disease. | 23803974 |
| Liver Cirrhosis | Epigenetic Alterations | Circulating microRNAs as a Fingerprint for Liver Cirrhosis. | 23805240 |
| Carcinoma of lung, cell transformation, Neoplasms | Epigenetic Alterations | To date, aberrant DNA methylation has been shown to be one of the most common and early causes of malignant cell transformation and tumors of different localizations, including lung cancer. | 23806794 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer. | 23806809 |
| Metastasis | Epigenetic Alterations | Then, we compared the level of three miRNAs (miR-21, miR-146a, and miR-148a) with the total of 79 GC patients with or without LN metastasis. | 23806809 |
| Hepatocellular Carcinoma pN0 TNM Finding v8 | Epigenetic Alterations | Levels of the miRNAs were significantly different between pN0 and pN0 in the pT1 group (P = 0.013, P = 0.004, and P = 0.035, respectively) and among clinical stages (P = 0.001, P = 0.002, and P < 0.001, respectively). | 23806809 |
| Liver carcinoma | Epigenetic Alterations | Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma. | 23810247 |
| Liver carcinoma | Epigenetic Alterations | Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma. | 23812667 |
| Liver carcinoma | Epigenetic Alterations | A 30-miRNA signature consisting of 10 downregulated and 20 upregulated miRNAs was established for distinguishing hepatocellular carcinoma from noncancerous liver tissues in the training set with 99.2% accuracy. | 23812667 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in the development and progression of cancer. | 23812667 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-203 down-regulation is associated with unfavorable prognosis in human glioma. | 23813496 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-203 (miR-203) serves as a tumor suppressor or a tumor promoter in different human malignancies. | 23813496 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Increased skeletal muscle-specific microRNA in the blood of patients with COPD. | 23814167 |
| Structure of quadriceps femoris muscle, Chronic Obstructive Airway Disease, Skeletal muscle weakness | Epigenetic Alterations | Reduced expression of muscle-specific microRNA (myomiRs) in quadriceps muscle in patients with COPD is associated with skeletal muscle weakness and changes in muscle fibre composition. | 23814167 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Muscle-specific miRNA was elevated in the plasma of patients with COPD and showed distinct patterns. | 23814167 |
| Acute lymphocytic leukemia, Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNA-223 mimics was transfected to increase the expression of MicroRNA-223 in the lymphocytes sorted by ficoll separation from the bone marrow mononuclear cells (BMMNC) of ALL and CLL patients. | 23815897 |
| Acute lymphocytic leukemia, Chronic Lymphocytic Leukemia | Epigenetic Alterations | The results indicated that before the transfection, the expression of MicroRNA-223 in ALL and CLL cells was (433.11 +- 144.88), which was significantly lower than that in the normal lymphocyte (949.59 +- 267.39); the expression of LMO2 was (807.10 +- 238.41), which was significantly higher than that in the normal lymphocytes (455.32 +- 176.83) (P < 0.05); after the transfection, the expression of MicroRNA-223 was (571.86 +- 142.00) in ALL and CLL cells, which was significantly higher than that before transfection (P < 0.05), but the expression of LMO2 was significantly lower than that before transfection (651.97 +- 230.12) (P < 0.05); in the normal control the expression of MicroRNA-223 obviously decreased (646.32 +- 172.93) (P < 0.05), the expression of LMO2 was significantly increased (541.27 +- 158.86.2) (P < 0.05). | 23815897 |
| Lymphoid leukemia, Abnormal lymphocyte apoptosis | Epigenetic Alterations | It is concluded that the expression of MicroRNA-223 decreases, and the expression of LMO2 increases in lymphocytic leukemia cells which leads to the lymphocytes over-proliferation and abnormal apoptosis, thus may be one of pathogenesis in lymphocytic leukemia. | 23815897 |
| Malignant Neoplasms | Epigenetic Alterations | Altered microRNA (miRNA) expression has been found in many cancers, including lung, breast, prostate, bladder and colorectal cancer. | 23817697 |
| Laryngeal Squamous Cell Carcinoma | Epigenetic Alterations | However, the alteration in plasma miRNA expressions in laryngeal squamous cell carcinoma (LSCC) remains unclear. | 23817697 |
| Laryngeal Squamous Cell Carcinoma | Epigenetic Alterations | Differential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma. | 23817697 |
| Malignant Neoplasms | Epigenetic Alterations | Many recent studies have demonstrated that aberrant plasma miRNAs were also found in various types of cancers. | 23817697 |
| Injury of central nervous system | Epigenetic Alterations | Differential miRNA expression may therefore provide insight into mechanisms responsible for distinct phenotypic and functional properties of myeloid cells, thus impacting their ability to influence CNS injury and repair. | 23818336 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are small, noncoding RNAs that are critical regulators of various diseases, including cancer, which may represent a novel class of cancer biomarkers. | 23819812 |
| cervical cancer | Epigenetic Alterations | We hypothesized that microRNA-20a (miR-20a) and microRNA-203 (miR-203), which were altered in lymphatic metastatic tissues, could be directly assayed in the serum and used to detect the lymph node status of cervical cancer patients. | 23819812 |
| cervical cancer, Metastasis | Epigenetic Alterations | Circulating miRNA-20a and miRNA-203 for screening lymph node metastasis in early stage cervical cancer. | 23819812 |
| Breast Carcinoma | Epigenetic Alterations | We have developed a user-friendly, web-based system to allow the evaluation of genes/microRNAs (miRNAs) that are significantly associated with survival in breast cancer and its molecular subtypes. | 23820017 |
| Malignant Neoplasms, Primary malignant neoplasm, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) play a key role in cancer pathogenesis and are involved in several human cancers, including non-small cell lung cancer (NSCLC). | 23820752 |
| Squamous cell carcinoma, Adenocarcinoma, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | No significant association was observed between the analysed miRNAs and the main clinicopathological or molecular characteristics of the NSCLC patients, although both miRNAs were downregulated in squamous cell carcinomas compared to adenocarcinomas. | 23820752 |
| Aggressive behavior, Ocular Adnexal Lymphoma | Epigenetic Alterations | MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease. | 23821202 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | We conclude that fundamental differences in miRNA expression exist between ocular adnexal EMZL and DLBCL, mainly due to differences in MYC and NF-kB regulatory pathways. | 23821202 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Seven of the miRNAs down-regulated in DLBCL relative to EMZL showed enrichment for a direct transcriptional repression by the oncoprotein MYC. | 23821202 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Noncoding RNAs play a pivotal role in the pathogenesis of chronic lymphocytic leukemia (CLL). | 23821659 |
| Lymphocyte count increased, Chronic Lymphocytic Leukemia | Epigenetic Alterations | We hypothesized that microRNAs (miRs) are involved in the transition from monoclonal B-cell lymphocytosis (MBL) to CLL and tested miR-15a/16-1 cluster, miR-21, and miR-155 expression in purified B cells of normal individuals, individuals with MBL, and patients with CLL. | 23821659 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | MicroRNA (miRNA) may be potential biomarkers of Alzheimers disease (AD). | 23822153 |
| Admitting diagnosis | Epigenetic Alterations | In conclusion, miRNA present in human biofluids may offer utility as biomarkers of AD. | 23822153 |
| Plaque (lesion) | Epigenetic Alterations | The objective of this investigation was to demonstrate that miRNAs in human brain or biofluids are differentially expressed according to disease status, tissue type, neuritic plaque score or Braak stage. | 23822153 |
| Ovarian Serous Adenocarcinoma | Epigenetic Alterations | High-grade serous ovarian carcinoma (HG-SOC) is a heterogeneous, poorly classified, lethal disease that frequently exhibits altered expressions of microRNAs. | 23825028 |
| Muscle, Smooth, Vascular | Epigenetic Alterations | We previously showed that constitutive Smad2 activation is associated with Smad2 mRNA overexpression in aneurysmal vascular smooth muscle cells (VSMCs), which is dependent on epigenetic regulation of the SMAD2 promoter involving histone modifications. | 23825360 |
| NCI CTEP SDC Oligodendroglial Tumors Sub-Category Terminology | Epigenetic Alterations | Genetic and epigenetic alterations in primary-progressive paired oligodendroglial tumors. | 23826216 |
| Primary Neoplasm | Epigenetic Alterations | Epigenetic analysis detected promoter methylation of the MGMT, P16, DAPK, PTEN, RASSF1A, and Rb1 genes in 38.1%, 19.0%, 38.1%, 33.3%, 66.7%, and 14.3% of primary tumors, respectively. | 23826216 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Down-regulation of microRNA-181b is a potential prognostic marker of non-small cell lung cancer. | 23827213 |
| S100A4 protein, human | Epigenetic Alterations | Further investigation and validation of our microRNA database of MPM may elucidate previously unrecognized molecular pathways and/or mechanisms by identifying novel microRNAs that are involved in malignant transformation. | 23828229 |
| Neoplasms | Epigenetic Alterations | In addition to several novel MPM-associated microRNAs, we observed that the expression level of miR-1 was significantly lower in tumors as compared with normal pleural specimens. | 23828229 |
| Gastric Adenocarcinoma | Epigenetic Alterations | We studied the comprehensive DNA methylation status in the naturally derived gastric adenocarcinoma cell line SNU-719, which was infected with the Epstein-Barr virus (EBV) by methylated CpG island recovery on chip assay. | 23829175 |
| Primary malignant neoplasm | Epigenetic Alterations | We verified DNA methylation of the genes in 75 primary gastric cancer tissues from 25 patients with EBVaGC and 50 EBV-negative patients who were controls. | 23829175 |
| B-Cell Lymphomas | Epigenetic Alterations | Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. | 23831920 |
| Neoplasms | Epigenetic Alterations | To identify a unique microRNA (miRNA) pattern associated with the progression of OSC at early and advanced stages, a miRNA microarray was performed using Chinese tumor bank specimens of patients with OSC stage I or III in a retrospective analysis. | 23836287 |
| Ovarian Serous Adenocarcinoma | Epigenetic Alterations | MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. | 23836287 |
| Carcinoma of lung | Epigenetic Alterations | For TIMP3, males showed lower methylation frequency than females (OR=0.18, 95%CI=0.04-0.88) while central lung cancer, heavy smoking and radiation exposure presented higher aberrant DNA methylation status (OR=2.19, 95%CI=1.07-4.52; OR=6.99, 95%CI=1.32-37.14; OR=2.30, 95%CI=1.04-5.08). | 23838140 |
| Primary malignant neoplasm | Epigenetic Alterations | There is increasing evidence that microRNA expression in cancer tissue is useful for predicting the prognosis of patients with cancer. | 23838916 |
| Esophageal carcinoma | Epigenetic Alterations | However, the relationship between the levels of circulating microRNAs and response to chemotherapy and prognosis remains unclear in esophageal cancer. | 23838916 |
| Neoplasms | Epigenetic Alterations | Tissue sections from the deepest invasive tumour front were processed for miRNA-126 ISH and CD34 immunohistochemistry (IHC). | 23838926 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The functional significance of microRNA-29c in patients with colorectal cancer: a potential circulating biomarker for predicting early relapse. | 23840538 |
| Clinical Coordinator | Epigenetic Alterations | We recently identified microRNA-29c (miRNA-29c) as a predictor of early recurrence in CRC. | 23840538 |
| Clinical Coordinator | Epigenetic Alterations | miRNA-29c expression significantly decreased during early relapse compared to non-early relapse in UICC stage II and III CRC patients (P = 0.021). | 23840538 |
| Neoplasms | Epigenetic Alterations | In vivo, miRNA-29c suppressed tumor growth in null mice. | 23840538 |
| Clinical Coordinator | Epigenetic Alterations | miRNA-29c shows anti-tumorigenesis activity, and preoperative circulating miRNA-29c levels can be used to predict postoperative early relapse of CRC. | 23840538 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | microRNAs have been suggested to play roles in carcinogenesis and cancer recurrence. | 23840538 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | We compared miRNA expression profiles in lymph node tissues of patients with DLBCL of the activated B-cell like (ABC) type from two geographical areas with different background exposures, Sweden and Egypt. | 23841503 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | DNA methylation is associated with bladder cancer and these modifications could serve as useful biomarkers. | 23842048 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | Downregulation of microRNA-100 correlates with tumor progression and poor prognosis in hepatocellular carcinoma. | 23842624 |
| S100A4 protein, human, Neoplasms | Epigenetic Alterations | Increasing evidence suggests that dysregulation of microRNAs is correlated with malignant transformation and tumor development. | 23842624 |
| Malignant Neoplasms, Retinitis Pigmentosa | Epigenetic Alterations | Recurrence-associated miRNAs were subsequently quantitated by qRT-PCR in a validation cohort comprised of 70 patients with Gleason 7 cancers treated by RP, 31 of whom had undergone disease progression following surgery. | 23846169 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2. | 23846336 |
| Primary malignant neoplasm | Epigenetic Alterations | Over-expression of long non-coding RNA HOTAIR has been reported in several types of cancer. | 23847441 |
| Central visual impairment | Epigenetic Alterations | Taken together, our data suggest that common genetic variations in COL1A2 may influence CVI risk, possibly through microRNA-382-mediated regulation. | 23849651 |
| DICER1 protein, human | Epigenetic Alterations | Dicer is an RNase III enzyme essential for the maturation of the majority of microRNAs. | 23851498 |
| Prostate Cancer Pathway, DICER1 protein, human, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Complete ablation of Dicer activity in a Pten null mouse model for prostate cancer significantly halts tumor growth and progression, demonstrating that microRNAs have a critical role in maintaining cancer cell fitness. | 23851498 |
| Breast Carcinoma | Epigenetic Alterations | Estrogen receptor a regulates ATM Expression through miRNAs in breast cancer. | 23857602 |
| Cerebrovascular Disorders | Epigenetic Alterations | Serum microRNA-21 and microRNA-221 as potential biomarkers for cerebrovascular disease. | 23860376 |
| Cerebrovascular accident | Epigenetic Alterations | To test the prediction for stroke, we built regression models containing the serum miRNA levels and risk factors. | 23860376 |
| cervical cancer | Epigenetic Alterations | MicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer. | 23861821 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-34a targets Bcl-2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment. | 23862748 |
| Hepatitis B, Liver carcinoma | Epigenetic Alterations | Microvesicle microRNA profiles and functional roles between chronic hepatitis B and hepatocellular carcinoma. | 23864279 |
| Hollings Cancer Center, Complete atrioventricular block | Epigenetic Alterations | We demonstrated that CHB and HCC displayed aberrantly co-expressed MV miRNA profiles for the first time, which may have a link between CHB and HCC. | 23864279 |
| Hollings Cancer Center, Complete atrioventricular block | Epigenetic Alterations | Among them, 25 co-expressed MV miRNAs targeted 21 inflammatory factors and these miRNAs may be a tight linkage between CHB and HCC. | 23864279 |
| Hollings Cancer Center, Complete atrioventricular block | Epigenetic Alterations | Those MV miRNAs may play roles in CHB developing to HCC. | 23864279 |
| Hollings Cancer Center, Complete atrioventricular block | Epigenetic Alterations | Those MV miRNAs may serve as early biomarkers for HCC and may aid to promote CHB developing to HCC. | 23864279 |
| Adenoma | Epigenetic Alterations | Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. | 23868178 |
| Colorectal Cancer Pathway, Adenocarcinoma | Epigenetic Alterations | Recent studies have shown two distinct non-CIMP methylation clusters in colorectal cancer, raising the possibility that DNA methylation, involving non-CIMP genes, may play a role in the conventional adenoma-carcinoma pathway. | 23868178 |
| Adenoma | Epigenetic Alterations | A total of 135 adenomas (65 left colon and 70 right colon) were profiled for epigenome-wide DNA methylation using the Illumina HumanMethylation450 BeadChip. | 23868178 |
| Adenoma | Epigenetic Alterations | Linear regression and linear mixed effects models were used to identify locus-specific differential DNA methylation in adenomas of right and left colon. | 23868178 |
| Adenoma | Epigenetic Alterations | In summary, our results indicate distinct patterns of DNA methylation, independent of CIMP genes, in adenomas of the right and left colon. | 23868178 |
| Pterygium | Epigenetic Alterations | miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. | 23872359 |
| Pterygium | Epigenetic Alterations | Genome-wide miRNA and mRNA expression profiling of paired pterygium and normal conjunctiva was performed in the context of conventional excision of pterygium with autotransplantation of conjunctiva (n = 8). | 23872359 |
| Pterygium | Epigenetic Alterations | In pterygium, 25 miRNAs and 31 mRNAs were significantly differentially expressed by more than two-fold compared to normal conjunctiva. | 23872359 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. | 23874207 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | In summary, our findings suggest NTRK3 is a conditional tumor suppressor gene that is commonly inactivated in colorectal cancer by both epigenetic and genetic mechanisms whose function in the pathogenesis of colorectal cancer depends on the expression status of its ligand, NT-3. | 23874207 |
| Metastasis, Neoplasms | Epigenetic Alterations | High-throughput miRNA and mRNA sequencing of paired colorectal normal, tumor and metastasis tissues and bioinformatic modeling of miRNA-1 therapeutic applications. | 23874421 |
| Colorectal Cancer Pathway, Metastasis, Neoplasms | Epigenetic Alterations | To identify potential miRNA drugs in colorectal cancer, we profiled miRNA and mRNA expression in matching normal, tumor and metastasis tissues of eight patients by Illumina sequencing. | 23874421 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | We validated six miRNAs in a large tissue screen containing 16 additional tumor entities and identified miRNA-1, miRNA-129, miRNA-497 and miRNA-215 as constantly de-regulated within the majority of cancers. | 23874421 |
| Mammary Neoplasms | Epigenetic Alterations | This data presents miR-379 as a novel regulator of Cyclin B1 expression, with significant loss of the miRNA observed in breast tumours. | 23874748 |
| Hepatocarcinogenesis | Epigenetic Alterations | Epigenetic alterations are well documented in hepatocarcinogenesis. | 23875825 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Identification of microRNAs in blood and urine as tumour markers for the detection of urinary bladder cancer. | 23877086 |
| Bladder Neoplasm | Epigenetic Alterations | Three blood miRNAs (miR-26b-5p, miR-144-5p, miR-374-5p) were found to be significantly upregulated in invasive bladder tumour patients (P<0.05) when compared to the control group. | 23877086 |
| Neoplasms | Epigenetic Alterations | The expression of 2 miRNAs (miR-618, miR-1255b-5p) in the urine of patients with invasive tumours was significantly (P<0.05) increased in comparison to the control group. | 23877086 |
| Benign neoplasm of bladder | Epigenetic Alterations | In addition, it was shown that invasive bladder tumours could be identified by differentially expressed urine miRNAs. | 23877086 |
| diabetic, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by differential DNA methylation of GLP1R in pancreatic islets of type 2 diabetic patients. | 23879380 |
| Neoplasms | Epigenetic Alterations | Currently, the methylation epigenetic silencing of miRNAs with tumor suppressor features by CpG island hypermethylation is emerging as a common hallmark of different tumors. | 23880861 |
| Malignant Neoplasms | Epigenetic Alterations | The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanism, diagnosis and treatment of human cancers. | 23880861 |
| Malignant neoplasm of kidney | Epigenetic Alterations | DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome. | 23881922 |
| Primary malignant neoplasm | Epigenetic Alterations | Data of an independent ccRCC cohort from The Cancer Genome Atlas (TCGA) were analyzed on MCT4 mRNA (n = 482) and DNA methylation (n = 283) level. | 23881922 |
| Imprinting (Psychology) | Epigenetic Alterations | However, early investigations suggested that children born as a result of ART had higher risk of diseases with epigenetic etiologies, including imprinting disorders caused by a lack of maternal methylation at imprinting control elements. | 23884645 |
| Chronic disease | Epigenetic Alterations | The level of these miRNAs may serve as new potential biomarkers for this chronic disease. | 23885139 |
| Primary malignant neoplasm | Epigenetic Alterations | When present in PRC2, EZH2 catalyzes trimethylation on lysine 27 residue of histone H3, resulting in epigenetic silencing of gene expression and cancer progression. | 23887863 |
| High-Resolution Microendoscopy | Epigenetic Alterations | HRM is as a simple, cost-effective method for the reliable high-throughput quantification of DNA methylation in clinical material. | 23888343 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | The aberrant promoter methylation of tumor suppressor genes is a typical epigenetic alteration for breast cancer and can be detected in early carcinogenesis. | 23888343 |
| Breast Carcinoma | Epigenetic Alterations | The main purpose of our study was to optimize a high-resolution melting (HRM) assay for the reliable and quantitative assessment of RASSF1 gene methylation, which is considered one of the earliest epigenetic alterations in breast cancer. | 23888343 |
| Carcinogenesis | Epigenetic Alterations | However, the effects of ROS on miRNAs expression and the role of miRNAs in ROS-mediated injury on carcinogenesis are uncertain. | 23888942 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant DNA methylation is a recognized feature of human cancers and folate is directly involved in DNA methylation via one-carbon metabolism. | 23888945 |
| Malignant Neoplasms | Epigenetic Alterations | Folate supplement and recovery of aberrant DNA methylation status may offer a new strategy for prevention and therapy of cancers. | 23888945 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Tumor-suppressive microRNA-1291 directly regulates glucose transporter 1 in renal cell carcinoma. | 23889809 |
| Neoplasms | Epigenetic Alterations | Differences in microRNA expression during tumor development in the transition and peripheral zones of the prostate. | 23890084 |
| Neoplasms | Epigenetic Alterations | MicroRNA signatures that are specific for PZ and TZ tumors could also lead to more accurate prognoses, since tumors arising in the PZ tend to be more aggressive than tumors arising in the TZ. | 23890084 |
| Neoplasms | Epigenetic Alterations | The results also indicate that separate miRNA expression signatures for diagnosis might be needed for tumors arising in the different zones. | 23890084 |
| Neoplasms | Epigenetic Alterations | In addition, tumors arising in the TZ have more unique differentially expressed miRNAs compared to the PZ. | 23890084 |
| Scleroderma | Epigenetic Alterations | Detection of hair-microRNAs as the novel potent biomarker: evaluation of the usefulness for the diagnosis of scleroderma. | 23890704 |
| Malignant Neoplasms, Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and is caused by the accumulation of genetic and epigenetic alterations in regulatory genes. | 23891693 |
| Bone necrosis | Epigenetic Alterations | Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw. | 23892139 |
| Bone lesion | Epigenetic Alterations | Differences in DNA methylation induced by BP treatment could be involved in the pathogenesis of the bone lesion. | 23892139 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Clinic significance of microRNA-99a expression in human lung adenocarcinoma. | 23893385 |
| Zebrafish, Sample Size Calculation | Epigenetic Alterations | Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor b. | 23893664 |
| Sample Size Calculation | Epigenetic Alterations | Although several miRNAs have been shown to regulate autoimmune pathogenesis by affecting lymphocyte function, the roles of miRNAs in the pathogenesis of SSc remain unclear. | 23893664 |
| Sample Size Calculation | Epigenetic Alterations | The expression of these miRNAs in sera of SSc patients and healthy controls was measured by quantitative PCR. | 23893664 |
| Sample Size Calculation | Epigenetic Alterations | Nineteen of 95 miRNAs were significantly decreased in the sera of SSc patients. | 23893664 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Unique DNA methylation loci distinguish anatomic site and HPV status in head and neck squamous cell carcinoma. | 23894057 |
| nervous system disorder, Admitting diagnosis | Epigenetic Alterations | The data indicate that deregulated miRNAs in blood might be used as biomarkers in the diagnosis of AD or other neurological diseases. | 23895045 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Overexpression of primary microRNA 221/222 in acute myeloid leukemia. | 23895238 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The expression of 636 human miRNAs was compared between samples from 52 patients with AML and 13 healthy individuals by highly specific locked nucleic acid (LNA) based microarray technology. | 23895238 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | 64 miRNAs were significantly differentially expressed between AML and controls. | 23895238 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Expression of some miRNAs is strongly regulated at the posttranscriptional level in AML. | 23895238 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Deficiency in expression and epigenetic DNA Methylation of ASS1 gene in nasopharyngeal carcinoma: negative prognostic impact and therapeutic relevance. | 23897555 |
| Aggressive behavior, Neoplasms | Epigenetic Alterations | Attributable to epigenetic DNA methylation, ASS1 deficiency may link to the therapeutic sensitivity to the arginine-depriving agents and promote tumor aggressiveness through its newly identified tumor suppressor function. | 23897555 |
| Aggressive behavior, Neoplasms | Epigenetic Alterations | In summary, ASS1 protein deficiency was seen in approximately a half of NPCs and associated with advanced T classification, DNA methylation, and clinical aggressiveness, consistent with its tumor suppressor role. | 23897555 |
| Carcinoma, Transitional Cell, Ulcerative Colitis | Epigenetic Alterations | Variations in urothelial carcinoma (UC) response to platinum chemotherapy are common and frequently attributed to genetic and epigenetic variations of somatic DNA. | 23897706 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | miRNAs have features of potential biomarkers, and an altered expression of miRNAs was shown in established rheumatoid arthritis (RA). | 23897768 |
| Right arm | Epigenetic Alterations | To analyse RA associated miRNAs in the sera of patients with ERA to find markers of early disease, clinical activity or predictors of disease outcome. | 23897768 |
| Right arm | Epigenetic Alterations | From all analysed miRNAs, levels of miR-146a, miR-155 and miR-16 were decreased in the sera of ERA patients in comparison with established RA. | 23897768 |
| Gastric Adenocarcinoma | Epigenetic Alterations | Evaluation of MicroRNA expression pattern of gastric adenocarcinoma associated with socioeconomic, environmental and lifestyle factors in northwestern Hungary. | 23898078 |
| Primary malignant neoplasm | Epigenetic Alterations | Since microRNAs (miRNAs) represent an emerging field of cancer research, there is an increasing interest regarding the miRNA responses to environmental and lifestyle exposures. | 23898078 |
| Gastric Adenocarcinoma | Epigenetic Alterations | Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic regions population show homogenous correlations with the existence of common risk factors. | 23898078 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidence has identified that polymorphism residing in the microRNA (miRNA) binding site of target genes can affect the strength of miRNA binding and influence individual susceptibility to cancer. | 23900673 |
| Neoplasms | Epigenetic Alterations | These tumors overexpress HIF-1a protein and target genes and the HIF-inducible microRNA miR-210 (pHx-HNPGLs). | 23902947 |
| Neoplasms | Epigenetic Alterations | In miRNAs that were downregulated in the tumors, Let-7f-2 and miR-22 differed the most (P < 0.001 and P = 0.007, respectively). | 23904007 |
| Neoplasms | Epigenetic Alterations | We postulate that mRNA-protein decoupling of BCAR1 may be a result of reduced inhibition of specific miRNAs in tumor tissues, which warrants further study. | 23904007 |
| Breast Carcinoma | Epigenetic Alterations | Evaluation of protein expression and DNA methylation profiles detected by pyrosequencing in invasive breast cancer. | 23906298 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | By using pyrosequencing, we analysed DNA methylation levels of 11 genes, namely APC, ADAM23, CXCL12, ESR1, PGR B, CDH1, RASSF1A, SYK, TIMP3, BRMS1 and SOCS1 in tumour, plasma and peripheral blood cells from 34 patients with primary breast cancer, as well as plasma and peripheral blood cells from 50 healthy controls. | 23906298 |
| Neoplasms | Epigenetic Alterations | On the other hand, no correlations were observed in patients between DNA methylation in tumours and cell-free plasma DNA. | 23906298 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | The DNA methylation profiles manifested in our group of breast carcinomas are cancer specific, but they are not the only cause that affects the silencing of evaluated genes and the decrease of relevant protein products. | 23906298 |
| palladium | Epigenetic Alterations | Importantly, we identified concordant methylation alterations in brain and blood, suggesting that blood might hold promise as a surrogate for brain tissue to detect DNA methylation in PD and as a source for biomarker discovery. | 23907097 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | Upregulation of microRNA-203 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer. | 23918241 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNA-203 (miR-203), possessing tumor suppressive or promotive activities, has been found to be downregulated or upregulated in different cancer types. | 23918241 |
| Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer. | 23918943 |
| Neoplasms | Epigenetic Alterations | Circulating profiles of miRNAs have been shown to discriminate different tumor types, indicate staging and progression of the disease and to be useful as prognostic markers. | 23922807 |
| Glioblastoma Multiforme | Epigenetic Alterations | Relationship between magnetic resonance imaging features and miRNA gene expression in patients with glioblastoma multiforme. | 23924460 |
| Neoplasms | Epigenetic Alterations | Recent research has shown that microRNAs (miRNAs) may act as oncogenes, or in some cases, tumor suppressor genes that in turn may reflect the genotypic features of GBM. | 23924460 |
| Neoplasms | Epigenetic Alterations | The miRNAs such as hsa-miR-95, hsa-miR-498, and hsa-miR-1300 were associated with a contrast tumor enhanced/T2 ratio >=1. | 23924460 |
| MIR524 gene, Hemorrhage, MIR612 gene | Epigenetic Alterations | The miRNAs such as hsa-miR-612, hsa-miR-524-3, and hsamiR-1282 were associated with multiple lesions identified on MRI and the expression of miR-221 was associated with hemorrhage by GBM. | 23924460 |
| Necrosis | Epigenetic Alterations | The gene expression of miRNAs such as hsa-miR-140-5p, hsa-miR-30e, and hsa-miR-301a was relatively low when compared with the larger necrotic volume group as identified by MRI. | 23924460 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations are a hallmark of cancer that govern the silencing of genes. | 23924947 |
| Barrett Esophagus | Epigenetic Alterations | MicroRNA expression differentiates squamous epithelium from Barretts esophagus and esophageal cancer. | 23925817 |
| Biliary | Epigenetic Alterations | MicroRNA profiles in graft preservation solution are predictive of ischemic-type biliary lesions after liver transplantation. | 23928409 |
| Biliary stricture | Epigenetic Alterations | MicroRNA profiles in perfusates from grafts that developed ITBL (n=20) and grafts without biliary strictures (n=37) were compared. | 23928409 |
| Ischemia | Epigenetic Alterations | Graft preservation solutions (perfusates) and paired liver biopsies collected at the end of cold ischemia were analysed by RT-qPCR for CDmiR-30e, CDmiR-222, and CDmiR-296 and hepatocyte-derived miRNAs (HDmiRs) HDmiR-122 and HDmiR-148a. | 23928409 |
| Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. | 23931760 |
| Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. | 23931760 |
| Endoribonuclease ZC3H12A | Epigenetic Alterations | Our findings provide an example of treatment-induced epigenetic organ remodeling in humans. | 23931760 |
| Pancreatic carcinoma | Epigenetic Alterations | Evidence suggests that deregulated miRNA expression is associated with pancreatic cancer development. | 23933230 |
| Pancreatic Ductal Adenocarcinoma, Pancreatic intraepithelial neoplasia | Epigenetic Alterations | MicroRNAs as diagnostic markers for pancreatic ductal adenocarcinoma and its precursor, pancreatic intraepithelial neoplasm. | 23933230 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Clinical significance of microRNA-148a in patients with early relapse of stage II stage and III colorectal cancer after curative resection. | 23933284 |
| Clinical Coordinator | Epigenetic Alterations | We used microRNA arrays and identified that microRNA-148a (miRNA-148a) had substantially different expression levels in early and nonearly relapsed stage II and III CRC tissues. | 23933284 |
| Clinical Coordinator | Epigenetic Alterations | Subsequently, we explored whether the serum level of miRNA-148a can be used to predict early CRC recurrence. | 23933284 |
| Clinical Coordinator | Epigenetic Alterations | This study showed that miRNA-148a can inhibit tumorigenesis and reduce the early recurrence of CRC. | 23933284 |
| Clinical Coordinator | Epigenetic Alterations | These findings suggest that miRNA-148a may have potential clinical applications for predicting the early relapse of patients with CRC after radical resection. | 23933284 |
| Clinical Coordinator | Epigenetic Alterations | We aimed to determine whether expression status of microRNAs might be a simple and reliable biomarker to detect postoperative early relapse in patients with CRC after radical resection. | 23933284 |
| Esophageal carcinoma | Epigenetic Alterations | Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis. | 23933602 |
| Astrocytoma, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Genomic and epigenetic data on astrocytoma have demonstrated that the IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. | 23934769 |
| Primary malignant neoplasm | Epigenetic Alterations | Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. | 23936094 |
| Parkinson Disease | Epigenetic Alterations | LINE-1 DNA methylation, smoking and risk of Parkinsons disease. | 23938260 |
| Parkinson Disease | Epigenetic Alterations | Plasma-based circulating MicroRNA biomarkers for Parkinsons disease. | 23938262 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are small non-coding RNAs capable of inhibiting gene expression post-transcriptionally and expression profiling can provide therapeutic targets and tools for cancer diagnosis. | 23940002 |
| Chondrosarcoma | Epigenetic Alterations | We further validated the expression levels of miRNAs by quantitative real-time PCR for miR-181a, let-7a, 100, 222, 136, 376a, and 335 in extended number of chondrosarcoma clinical samples. | 23940002 |
| Hollings Cancer Center | Epigenetic Alterations | Our results suggested that the gene loss and epigenetic silencing of SOCS1 were strongly associated with HBV-related HCC. | 23941364 |
| Gastric mucosa, Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation in noncancerous gastric mucosa is strongly implicated in gastric carcinogenesis and could be a useful biomarker of GC risk. | 23942619 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Therefore, H19 CBS6 methylation potentially represents a novel clinically relevant epigenetic marker to identify individuals at increased risk for the occurrence, progression and prognosis of ESCC. | 23943562 |
| Stomach Carcinoma | Epigenetic Alterations | Examination of whole blood DNA methylation as a potential risk marker for gastric cancer. | 23943784 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Variability in whole blood DNA methylation of cancer markers is primarily associated with aging, reflecting turnover of white blood cells, and has no direct link to gastric cancer predisposition. | 23943784 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. | 23945108 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The verification of tumor-specific miRNA expression profile, together with the observed association of miR-141 and miR-205 expression with overall survival, underline the potential of miRNAs to function as diagnostic and/or prognostic markers of bladder cancer. | 23945108 |
| Malignant neoplasm of urinary bladder, MIR20A gene | Epigenetic Alterations | Seven miRNAs (miR-20a, miR-106b, miR-130b, miR-141, miR-200a, miR-200a*, and miR-205) were found to be up-regulated and eight miRNAs (miR-100, miR-125b, miR-130a, miR-139-5p, miR-145*, miR-199a-3p, miR-214, and miR-222) were found to be down-regulated in malignant bladder tissue samples compared to healthy tissue. | 23945108 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Four miRNAs that have already been described in the literature (miR-141, miR-199a-3p, miR-205, and miR-214) were significantly differentially expressed between nonmuscle-invasive and muscle-invasive bladder cancer. | 23945108 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Furthermore, real-time RT-qPCR of all miRNAs provided high overall correct classification (>75%) of bladder cancer diagnosis. | 23945108 |
| Carcinoma of lung | Epigenetic Alterations | microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer. | 23945385 |
| Granuloma, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Six microRNAs (miR-151a-5p, miR-30a-3p, miR-200b-5p, miR-629, miR-100, and miR-154-3p) were selected for a second test on the nodule population to discriminate between lung adenocarcinoma and granuloma. | 23945385 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | MicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma. | 23946296 |
| Adenocarcinoma of lung (disorder), Metastasis, Primary malignant neoplasm | Epigenetic Alterations | We conducted genome-wide miRNA-sequencing (miRNA-seq) in primary cancer tissue from patients of lung adenocarcinoma to identify markers for the presence of lymph node metastasis. | 23946296 |
| Hypernatremia, Aortic Valve Stenosis | Epigenetic Alterations | Myocardial microRNA-133a (miR-133a) is directly related to reverse remodeling after pressure overload release in aortic stenosis patients. | 23948643 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We recently reported a fecal microRNA (miRNA) test (FmiRT) to detect colorectal cancer. | 23950216 |
| Hollings Cancer Center | Epigenetic Alterations | We have previously delineated the landscape of DNA methylation in HCC patients unraveling the importance of promoter hypomethylation in activation of cancer- and metastasis-driving genes. | 23950870 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Although the main thrust in DNA methylation diagnostics in cancer is on hypermethylated genes, our study for the first time illustrates the potential use of hypomethylated genes as markers for solid tumors. | 23950870 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Although aberrant DNA methylation patterning is a hallmark of cancer, the relevance of targeting DNA methyltransferases (DNMT) remains unclear for most tumors. | 23955273 |
| Resistance Process, Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | In diffuse large B-cell lymphoma (DLBCL) we observed that chemoresistance is associated with aberrant DNA methylation programming. | 23955273 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have been integrated into cancer development and progression, because they repress translation of target genes which can be tumor suppressors and oncogenes. | 23959478 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | A number of miRNAs have been found to be closely related to human non-small cell lung cancer (NSCLC). | 23959478 |
| Admitting diagnosis | Epigenetic Alterations | In conclusion, the abnormal expression of several miRNAs in hippocampus of intermediate- and late-stage AD patients suggests their involvement in AD pathogenesis, and low levels of miR-146a in CSF were associated with AD. | 23962497 |
| Neoplasms | Epigenetic Alterations | The microRNA miR-101 has been reported to be a tumor suppressor. | 23962556 |
| Neoplasm Metastasis | Epigenetic Alterations | We also identified a subset of miRNAs associated with tumor metastasis and MCC-specific survival. | 23962809 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) play a crucial role in the pathogenesis of several malignancies via regulating gene expression. | 23963825 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant methylation in gene promoter is common in various cancers, and epigenetic alterations can result in down-regulation or silence of gene expression. | 23963856 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | A panel of 4 microRNAs facilitates the prediction of left ventricular contractility after acute myocardial infarction. | 23967079 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA) is an emerging subclass of small non-coding RNAs that regulates gene expression and has a pivotal role for many physiological processes including cancer development. | 23967217 |
| Malignant neoplasm of larynx | Epigenetic Alterations | MicroRNA-196a is a putative diagnostic biomarker and therapeutic target for laryngeal cancer. | 23967217 |
| estrogen receptor-positive breast cancer, Neoplasms | Epigenetic Alterations | We performed a global microRNA screen (1105 human microRNAs) in primary tumours of six matched pairs of postmenopausal, ER-positive breast cancer patients treated with tamoxifen, who were either recurrence free or had developed a recurrence (median follow up: 8.84 years; range: 1.28-12.7 years). | 23968733 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNAs have been suggested to be important prognosticators in breast cancer. | 23968733 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | MicroRNAs that may have an essential role in GIST pathogenesis were identified, in particular miR-17/20a/222 that target KIT and ETV1. | 23969726 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Delivering these microRNAs therapeutically could hold great potential for GIST management, especially in imatinib-resistant disease. | 23969726 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation has been recognized to contribute to breast carcinogenesis, and promoter hypermethylation of several tumor suppressor genes has been correlated with decreased gene expression. | 23969757 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic parameters such as DNA methylation and histone modifications play pivotal roles in carcinogenesis. | 23969945 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Global histone modification patterns have been implicated as possible predictors of cancer recurrence and prognoses in a great variety of tumor entities. | 23969945 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In conclusion, H3K27me3 level defines unrecognized subgroups of NSCLC patients with distinct epigenetic phenotype and clinical outcome, and can probably be used as a novel predictor for better prognosis in NSCLC patients. | 23969945 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) are small, noncoding RNAs that are involved in carcinogenesis through postranscriptional gene regulatory activity. | 23970420 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Prognostic implications of serum microRNA-21 in colorectal cancer. | 23970420 |
| Primary malignant neoplasm | Epigenetic Alterations | Growing evidence has indicated that polymorphism present in the miRNA binding site of target gene can alter the ability of miRNAs to bind its target gene and modulate the development and progression of cancer. | 23975373 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidence suggests that aberrant expression of long non-coding RNAs (lncRNAs) play an important functional role in cancer biology. | 23976967 |
| Fatty Liver Disease, Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | The importance of genetics and epigenetic changes in the pathogenesis of non alcoholic fatty liver disease (NAFLD) has been increasingly recognized. | 23977033 |
| Carcinoma of lung | Epigenetic Alterations | Optimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients. | 23978937 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | This method was applied to assess the optimal amounts of enzymes required for DNA digestion regarding an accurate global DNA methylation determination and completeness of digestion and to determine global methylation in human tumor adjacent lung tissue of 79 lung cancer patients. | 23978937 |
| Squamous cell carcinoma, Adenocarcinoma | Epigenetic Alterations | Global DNA methylation levels in adenocarcinoma and squamous cell carcinoma patients were similar in the range of 3.16-4.01 %. | 23978937 |
| Carcinoma of lung | Epigenetic Alterations | Global DNA methylation levels were not affected by smoking and gender and were not correlated with N7-meG or 8-oxodG in lung cancer patients. | 23978937 |
| Malignant Neoplasms | Epigenetic Alterations | Increasing evidence suggests that large-scale loss of 5-hmC is an epigenetic hallmark of several human cancers. | 23980508 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation of promoter region CpG islands may serve as an alternative mechanism to genetic defects in the inactivation of tumor suppressor genes (TSGs) in human malignancies. | 23980519 |
| Primary malignant neoplasm | Epigenetic Alterations | Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. | 23981575 |
| Stomach Carcinoma | Epigenetic Alterations | The aim of this study was to characterize the epigenetic inactivation of Reprimo and its biologic function and clinical relevance in gastric cancer. | 23982217 |
| Carcinoma | Epigenetic Alterations | Carcinomas initiate and progress due to genetic and epigenetic alterations in epithelial cells. | 23982433 |
| Metastasis | Epigenetic Alterations | After initial screening, miR-200c was selected as the candidate serum miRNA best associated with metastasis. | 23982750 |
| Clinical Coordinator, Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | To evaluate the ability of epithelial-to-mesenchymal transition-related microRNAs (miRNAs) as serum biomarkers for prognosis and prediction of metastasis in patients with colorectal cancer (CRC). | 23982750 |
| Clinical Coordinator, Metastasis | Epigenetic Alterations | Epithelial-to-mesenchymal transition-related miRNAs drive CRC progression and metastasis. | 23982750 |
| Clinical Coordinator, Metastasis | Epigenetic Alterations | In the first phase, we selected candidate miRNAs associated with metastasis by analyzing the expression of 4 miR-200 family members (miR-200b, -200c, -141, and -429) in serum samples from 12 patients with stage I and IV CRC. | 23982750 |
| Clinical Coordinator | Epigenetic Alterations | The second phase involved independent validation of candidate miRNAs in serum from 182 patients with CRC and 24 controls. | 23982750 |
| Clinical Coordinator, Secondary malignant neoplasm of liver, Neoplasms | Epigenetic Alterations | Finally, we analyzed expression in matched 156 tumor tissues from 182 patients with CRC and an independent set of 20 matched primary CRC and corresponding liver metastases to identify the source of circulating miRNAs. | 23982750 |
| Traumatic injury | Epigenetic Alterations | We identified a miRNA profile involved in posttranscriptional regulatory mechanisms in I/R injury post-LT. A better understanding of these molecular processes involved in I/R may contribute to develop new strategies to minimize graft injury. | 23985720 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Taken together, our data indicate that galectin-7 has a tumor suppressive function, and that the gene is epigenetically modified by DNA methylation and significantly down-regulated in gastric cancer. | 23985992 |
| Neoplasms | Epigenetic Alterations | Most changes in miRNA and gene expression levels had already manifested in the primary tumors while these levels were almost stably maintained in the subsequent primary tumor-to-metastasis transition. | 23987127 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | Using a large dataset of CRC miRNA and gene expression profiles, we describe the interplay of miRNA groups in regulating gene expression, which in turn affects modulated pathways that are important for tumor development. | 23987127 |
| Carcinogenesis, Metastasis | Epigenetic Alterations | Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis. | 23987127 |
| Malignant tumor of colon, Primary Neoplasm | Epigenetic Alterations | Qualitative alterations or abnormal expression of microRNAs (miRNAs) in colon cancer have mainly been demonstrated in primary tumors. | 23987127 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Poorly overlapping sets of oncomiRs, tumor suppressor miRNAs and metastamiRs have been linked with distinct stages in the progression of colorectal cancer. | 23987127 |
| Neoplasms | Epigenetic Alterations | Of 82 miRNAs that were modulated during tumor progression, 22 were involved in EMT. | 23987127 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island. | 23988185 |
| Primary malignant neoplasm | Epigenetic Alterations | Because the DNA methylation landscape of different regions of SEPT9 is poorly understood in cancer, we analyzed the methylation patterns of this gene in distinct cell populations from normal and diseased colon mucosa. | 23988185 |
| Osteoporosis | Epigenetic Alterations | Further evaluation of Alu hypomethylation may clarify the epigenetic regulation of osteoporosis in post-menopausal women. | 23990903 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRs) are small noncoding RNAs that function by suppressing gene expression and are dysregulated in cancer. | 23991015 |
| Metastasis, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis. | 23991015 |
| Neoplasms | Epigenetic Alterations | A simple quantitative diagnostic alternative for MGMT DNA-methylation testing on RCL2 fixed paraffin embedded tumors using restriction coupled qPCR. | 23993306 |
| Childhood Leukemia | Epigenetic Alterations | [MicroRNA-193b expression in newly diagnosed leukemia patients and its significance]. | 23998571 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | In order to more thoroughly analyze aberrant DNA methylation in glioma, we applied a large cohort methylation microarray including 119 glioma samples. | 24002581 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Epigenetic silencing of KAZALD1 confers a better prognosis and is associated with malignant transformation/progression in glioma. | 24002581 |
| Cholangiocarcinoma | Epigenetic Alterations | Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway. | 24002901 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic changes such as aberrant hypermethylation and subsequent atypical gene expression are characteristic features of most human cancers. | 24002901 |
| DNA Mismatch Repair Protein MSH2, human, Basal-Like Breast Carcinoma | Epigenetic Alterations | Protein expression and methylation of DNA repair genes hMLH1, hMSH2, MGMT and BRCA1 and their correlation with clinicopathological parameters and prognosis in basal-like breast cancer. | 24004112 |
| Hollings Cancer Center | Epigenetic Alterations | In conclusion, our data suggested that epigenetic silencing of TIG1 gene expression by promoter hypermethylation may play an important role in HCC. | 24006221 |
| Stomach Carcinoma | Epigenetic Alterations | Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. | 24006224 |
| Carcinoma of ampulla of Vater, Pancreatic Neoplasm, Pancreatitis | Epigenetic Alterations | Serum miRNA was examined by RT-PCR in a group of 49 patients, including 22 with PCs, 6 with benign pancreatic tumors, 7 with ampullary carcinomas, 6 with chronic pancreatitis and 8 healthy participants. | 24007214 |
| Adenocarcinoma of pancreas | Epigenetic Alterations | Analysis of serum exosomal microRNAs and clinicopathologic features of patients with pancreatic adenocarcinoma. | 24007214 |
| Carcinogenesis, Adenocarcinoma of pancreas | Epigenetic Alterations | Altered expression of serum microRNAs (miRNAs) have been reported to correlate with carcinogenesis and progression of pancreatic adenocarcinoma (PC), but descriptions of serum exosomal miRNAs in PC are still lacking. | 24007214 |
| Liver carcinoma | Epigenetic Alterations | microRNA-200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6. | 24009066 |
| Malignant Neoplasms, Disease | Epigenetic Alterations | Deregulation of microRNA-200a (miR-200a) has been observed in different types of diseases, including cancers. | 24009066 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Regulation of microRNA-1288 in colorectal cancer: altered expression and its clinicopathological significance. | 24009195 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Altered microRNA (miRNA) expression is frequently observed in acute myelogenous leukemia (AML) and has been implicated in leukemic transformation. | 24009227 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon. | 24009227 |
| Somatic | Epigenetic Alterations | Whether somatic copy number alterations (CNAs) are a frequent cause of altered miRNA gene expression is largely unknown. | 24009227 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Three other cases of AML were identified with very low to absent miR-223 expression, an miRNA gene known to play a key role in myelopoiesis. | 24009227 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | These data show that somatic CNAs specifically targeting miRNA genes are uncommon in AML. | 24009227 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | To identify clinically relevant tumor suppressor genes silenced by DNA methylation in HCC, we integrated DNA methylation data from human primary HCC samples with data on up-regulation of gene expression after epigenetic unmasking. | 24012984 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | Based on DNA methylation in primary HCC and gene re-expression in cell lines after epigenetic unmasking, we identified 13 candidate tumor suppressor genes. | 24012984 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma. | 24012984 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumor suppressor genes contributes to the pathogenesis of hepatocellular carcinoma (HCC). | 24012984 |
| Pancreatic carcinoma | Epigenetic Alterations | miRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4. | 24013097 |
| Pancreatic carcinoma, Neoplasms | Epigenetic Alterations | Therefore, we conclude that miR-141 targets MAP4K4, acts as a tumor suppressor in pancreatic cancer cells, and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy. | 24013097 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNAs are associated with various types of cancer due to their ability to affect expression of genes that modulate tumorigenesis. | 24013097 |
| Malignant Neoplasms, Malignant neoplasm of gallbladder | Epigenetic Alterations | Other patterns, such as tobacco-related cancers among ArA men and gall bladder and thyroid cancers among ArA women, will require more investigation of genetic, epigenetic, and environmental factors. | 24013772 |
| Transitional cell carcinoma of ureter | Epigenetic Alterations | We analyzed KLF4 expression and DNA methylation, and their clinical relevance and biological function in urothelial cancer. | 24018236 |
| Transitional cell carcinoma of ureter | Epigenetic Alterations | Epigenetic inactivation of KLF4 is associated with urothelial cancer progression and early recurrence. | 24018236 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-9 (miR-9) has various expression patterns in diverse human cancers. | 24019037 |
| Primary malignant neoplasm | Epigenetic Alterations | Emerging evidences indicate that dysregulated microRNAs are implicated in cancer tumorigenesis and progression. | 24019037 |
| Squamous cell carcinoma, Leukoplakia, SERPINB3 wt Allele | Epigenetic Alterations | Increased expression of microRNAs (miRNAs), miR-21, miR-345, and miR-181b has been demonstrated in oral leukoplakia (OL) that progresses to oral squamous cell carcinoma (OSCC), suggesting a miRNA signature with potential prognostic value. | 24020903 |
| SERPINB3 wt Allele | Epigenetic Alterations | We also compared the expression levels of these miRNAs in OL with normal oral mucosa and OSCC. | 24020903 |
| SERPINB3 wt Allele | Epigenetic Alterations | OSCC cases showed increased expression of all 3 miRNAs when compared with OL and normal oral mucosa. | 24020903 |
| Adenoma of large intestine, Colorectal Cancer Pathway | Epigenetic Alterations | A plasma microRNA panel for detection of colorectal adenomas: a step toward more precise screening for colorectal cancer. | 24022433 |
| Clinical Coordinator, Adenoma | Epigenetic Alterations | As intended, we undertook a more comprehensive plasma-miRNA screening study in patients with CR adenoma and CRC. | 24022433 |
| Clinical Coordinator | Epigenetic Alterations | Receiver-operating-characteristic curves of miRNA panels for all CRC versus controls and polyps versus all CRC showed AUC values of 0.829 (95% CI: 0.73-0.93) and 0.856 (95% CI: 0.75-0.97), respectively. | 24022433 |
| Clinical Coordinator, Adenoma | Epigenetic Alterations | We screened for 380 plasma-miRNAs using microfluidic array technology (Applied BioSystems) in a screening cohort of 12 healthy controls, 9 patients with CR adenomas, and 20 patients with CRC. | 24022433 |
| Clinical Coordinator, Adenoma | Epigenetic Alterations | A panel of the most dysregulated miRNAs (P < 0.05, False Discovery Rate: 5%) was then validated in a blinded cohort of 26 healthy controls, 16 patients with large adenomas, and 45 patients with CRC. | 24022433 |
| Clinical Coordinator | Epigenetic Alterations | In addition, a panel of 3 plasma miRNAs (miR-431, miR-15b, and miR-139-3p) distinguished Stage IV CRC from controls with an [AUC = 0.896 (95% CI: 0.78-1.0)]. | 24022433 |
| Adenoma | Epigenetic Alterations | Plasma miRNAs are reliable, noninvasive, and inexpensive markers for CR adenomas. | 24022433 |
| melanoma | Epigenetic Alterations | In-depth characterization of microRNA transcriptome in melanoma. | 24023765 |
| melanoma | Epigenetic Alterations | Surprisingly, the miRNA signature distinguishing specimens of melanoma from nevus was significantly different than that of melanoma cell lines from melanocytes. | 24023765 |
| melanoma, Primary malignant neoplasm | Epigenetic Alterations | From this data representing 698 known miRNAs, we defined a set of top-40 list, which properly classified normal from cancer; also confirming 23 (58%) previously discovered miRNAs while introducing an additional 17 (42%) known and top-15 putative novel candidate miRNAs deregulated during melanoma progression. | 24023765 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Diagnostic and prognostic value of plasma microRNA deregulation in nasopharyngeal carcinoma. | 24025417 |
| Primary malignant neoplasm | Epigenetic Alterations | There was a negative correlation between plasma miRNA expression and cancer progression, where miR-21 was statistically significant in T and N staging and miR-16 and 24 were significant in N staging only. | 24025417 |
| Chronic somatic dysfunction, Tubular atrophy, Interstitial Fibrosis Assessment | Epigenetic Alterations | Since microRNAs (miRNAs) have emerged as promising disease biomarkers, we sought to establish an miRNA signature in urinary cell pellets comparing kidney transplant patients diagnosed with chronic allograft dysfunction (CAD) with interstitial fibrosis and tubular atrophy and those recipients with normal graft function. | 24025639 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNA) have played an important role in carcinogenesis. | 24025765 |
| MMP8 wt Allele | Epigenetic Alterations | In summary, our results identify Axl as a key mediator of acquired erlotinib resistance in HNC and suggest that therapeutic inhibition of Axl by small molecule drugs or specific miRNAs might overcome anti-EGFR therapy resistance. | 24026012 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | These miRNAs are located on chromosome 13 in the 13q14.3 region, which is deleted in more than 55% of CLL patients. | 24026141 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Recent studies have revealed that long non-coding RNAs (lncRNAs) play important roles in cancer biology and that lncRNA gas5 (growth arrest-specific 5) regulates breast cancer cell growth. | 24026436 |
| Stomach Carcinoma | Epigenetic Alterations | Inhibition of mTOR signalling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation. | 24030871 |
| Stomach Carcinoma | Epigenetic Alterations | The relationship between mTOR pathway and histone acetylation is still unclear in gastric cancer (GC). | 24030871 |
| Malignant neoplasm of mouth | Epigenetic Alterations | Global analysis of DNA methylation changes during progression of oral cancer. | 24035722 |
| Malignant neoplasm of mouth, Primary malignant neoplasm | Epigenetic Alterations | In identifying aberrant DNA methylation at the earliest stages of oral precancer and finding recurring epigenetic disruption of specific genes/pathways across our analyzed cohort, we see evidence that CpG methylation changes may play a role in oral cancer progression and that global DNA methylation analyses may have significant utility in wider studies that seek to derive biomarkers or potentially druggable targets to improve oral cancer outcomes. | 24035722 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We provide the first evidence that variations in miRNA-binding sites in BER genes 3-UTR may modulate colorectal cancer prognosis and therapy response. | 24036853 |
| Primary malignant neoplasm | Epigenetic Alterations | Aging and cancer demonstrate profound genome-wide DNA methylation changes, suggesting that nutrition may affect the aging process and cancer development through epigenetic mechanisms. | 24038247 |
| Carcinoma of lung | Epigenetic Alterations | In summary, this study identifies a novel miRNA that targets PKCa and illustrates that the downregulation of PKCa by miR-203 modulates biological processes in lung cancer cells. | 24040137 |
| Carcinoma of lung, Carcinogenesis | Epigenetic Alterations | PKCa (protein kinase C alpha, PRKCA) is an important protein involved in several steps of signaling pathways in lung cancer, and microRNAs (miRNAs) have also been shown to participate in lung carcinogenesis. | 24040137 |
| Acute GVH disease | Epigenetic Alterations | Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. | 24041574 |
| Graft-vs-Host Disease | Epigenetic Alterations | Here, we show that plasma samples from aGVHD patients have a distinct microRNA (miRNA) expression profile. | 24041574 |
| Graft-vs-Host Disease | Epigenetic Alterations | In addition, the levels of these miRNAs were positively associated with aGVHD severity, and high expression of the miRNA panel was associated with poor overall survival. | 24041574 |
| Graft-vs-Host Disease | Epigenetic Alterations | Our results have identified a specific plasma miRNA signature that may serve as an independent biomarker for the prediction, diagnosis, and prognosis of aGVHD. | 24041574 |
| Graft-vs-Host Disease | Epigenetic Alterations | We have developed a model including 4 miRNAs (miR-423, miR-199a-3p, miR-93*, and miR-377) that can predict the probability of aGVHD with an area under the curve of 0.80. | 24041574 |
| Graft-vs-Host Disease | Epigenetic Alterations | Moreover, these elevated miRNAs were detected before the onset of aGVHD (median = 16 days before diagnosis). | 24041574 |
| Astrocytoma, Neoplasms | Epigenetic Alterations | Our results further indicate that epigenetic mechanisms are involved in silencing AKAP12 in diffuse astrocytomas; however, a tumor suppressive role of AKAP12 in distinct astrocytoma subtypes remains to be determined. | 24042196 |
| Acute lymphocytic leukemia | Epigenetic Alterations | DNA methylation of membrane-bound tyrosine phosphatase genes in acute lymphoblastic leukaemia. | 24045499 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Aberrant DNA promoter methylation with associated gene silencing is a common epigenetic abnormality in acute lymphoblastic leukaemia (ALL) and is associated with poor survival. | 24045499 |
| Malignant Neoplasms | Epigenetic Alterations | Methylation of the phosphatase promoters was reversible with decitabine and a histone deacetylase inhibitor, suggesting that PTPRK-mediated cell signalling pathways may be targeted with epigenetic therapies in lymphoid malignancy. | 24045499 |
| Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs), small noncoding RNAs, have been reported to be highly involved in the formation and progression of all types of human cancer including colorectal cancer (CRC). | 24045965 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Prognostic significance of microRNA-16 expression in human colorectal cancer. | 24045965 |
| Clinical Coordinator | Epigenetic Alterations | Therefore, miRNAs are also potential prognostic biomarkers in CRC patients. | 24045965 |
| Neoplasms | Epigenetic Alterations | Therefore, we focused on those miRNAs that are relevant to tumor differentiation. | 24045973 |
| Clinical Coordinator | Epigenetic Alterations | NEK2 may be an independent prognostic factor for CRC and was regulated by miR-128, a microRNA that was subjected to epigenetic regulation. | 24046120 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Up-regulation of NEK2 by microRNA-128 methylation is associated with poor prognosis in colorectal cancer. | 24046120 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Subversion of oncogene-induced senescence is a key step during cancer development, and many tumors have lost p16(INK4A) activity by mutation or epigenetic silencing. | 24046371 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Cell-free plasma microRNA in pancreatic ductal adenocarcinoma and disease controls. | 24048453 |
| Gastrointestinal Diseases | Epigenetic Alterations | In the plasma-miRNA population, we find miRNA-375, which is selectively expressed in the endocrine pancreas under normal conditions, increased in PDAC cases compared with patients with other pancreatic or gastrointestinal diseases. | 24048453 |
| CARCINOMA OF VULVA | Epigenetic Alterations | microRNA portraits in human vulvar carcinoma. | 24048714 |
| Human papilloma virus infection, Vulvar Neoplasms | Epigenetic Alterations | Our study characterizes microRNA in vulvar tumors through an expression profile of 754 miRNAs, relating this with clinical and anatomopathologic data, and presence of HPV infection. | 24048714 |
| CARCINOMA OF VULVA | Epigenetic Alterations | A network between microRNA expression profiles and putative target mRNAs predicted by target prediction algorithms and previously demonstrated as relevant in vulvar carcinomas, such as TP53, RB, PTEN, and EGFR was constructed. | 24048714 |
| CARCINOMA OF VULVA, Primary malignant neoplasm | Epigenetic Alterations | In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer. | 24048714 |
| Neoplasms | Epigenetic Alterations | Unregulated expression of microRNAs is well known and has already been demonstrated in many tumor types. | 24048714 |
| Neoplasms | Epigenetic Alterations | Twenty-five differentially expressed microRNAs between HPV-positive and HPV-negative groups and 79 differentially expressed on the tumor compared with normal samples were obtained. | 24048714 |
| Idiopathic chronic inflammatory bowel disease | Epigenetic Alterations | Novel specific microRNA biomarkers in idiopathic inflammatory bowel disease unrelated to disease activity. | 24051693 |
| Ulcerative Colitis, Crohn Disease | Epigenetic Alterations | Among them, a panel of nine miRNAs was aberrantly expressed in both ulcerative colitis and Crohn disease. | 24051693 |
| Septicemia, RNU6-50P gene, Fibrosis, Liver | Epigenetic Alterations | U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis. | 24052167 |
| Acute lymphocytic leukemia | Epigenetic Alterations | MicroRNA-142-3p inhibits cell proliferation in human acute lymphoblastic leukemia by targeting the MLL-AF4 oncogene. | 24057258 |
| Hemorrhage | Epigenetic Alterations | The effect of the plasma miRNA level on major adverse cardiovascular events (MACE) within one year and bleeding within six months were assessed. | 24058072 |
| Hemorrhage | Epigenetic Alterations | There was no significant association between the level of five plasma miRNAs and bleeding events during six-month follow-up. | 24058072 |
| Prostate Cancer Pathway | Epigenetic Alterations | Genetic variation in IL-16 miRNA target site and time to prostate cancer diagnosis in African-American men. | 24061634 |
| Prostate Cancer Pathway | Epigenetic Alterations | No association with time to prostate cancer diagnosis was found for the other miRNA target genotypes. | 24061634 |
| Prostate Cancer Pathway | Epigenetic Alterations | Genetic variation in IL-16 encoding miRNA target site may be informative of time to prostate cancer diagnosis among African-American men enrolled in prostate cancer risk assessment, which may inform individualized prostate cancer screening strategies in the future. | 24061634 |
| S-Adenosylhomocysteine | Epigenetic Alterations | Allelic variants of several enzymes within this pathway have been associated with altered SAM levels either directly, or indirectly as reflected by altered levels of SAH and Homocysteine levels, and altered levels of DNA methylation. | 24063603 |
| Endometrial | Epigenetic Alterations | Finally, the present study suggests that epigenetic alterations may be of diagnostic value for the better clinical management of premalignant endometrial lesions. | 24068440 |
| Neoplasms, Glioblastoma Multiforme | Epigenetic Alterations | The tumor suppressor microRNA, miR-124a, is regulated by epigenetic silencing and by the transcriptional factor, REST in glioblastoma. | 24068568 |
| Primary malignant neoplasm | Epigenetic Alterations | Reduced levels of specific microRNA in cancer are frequently reported and associated with attenuated cancer genes and associated pathways. | 24068568 |
| Atrial Fibrillation | Epigenetic Alterations | Impact of microRNA expression in human atrial tissue in patients with atrial fibrillation undergoing cardiac surgery. | 24069193 |
| Atrial Fibrillation | Epigenetic Alterations | Although microRNA (miRNA) regulates initiation and/or progression of atrial fibrillation (AF) in canine AF models, the underlying mechanism in humans remains unclear. | 24069193 |
| Fibrosis Assessment | Epigenetic Alterations | Percent fibrosis and miRNA-21 expression were correlated (r=0.508, p<0.05). | 24069193 |
| Fibrosis Assessment | Epigenetic Alterations | The expression of miRNA-21 in human atrial tissue was found to be related to atrial fibrosis and might affect AF occurrence, indicating its usefulness as a biomarker for cardiac surgery management. | 24069193 |
| Stomach Carcinoma | Epigenetic Alterations | We aimed to clarify its epigenetic regulation and biological functions in gastric cancer. | 24069310 |
| Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | MicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia. | 24072101 |
| Cytogenetics | Epigenetic Alterations | Here we report a potential association between miRNA expression and clinical outcome in 238 intermediate-risk cytogenetic AML (IR-AML) patients from 16 institutions in the CETLAM cooperative group. | 24072101 |
| Primary Biliary Cholangitis | Epigenetic Alterations | Decreased expression of miR-let-7b may be associated with development and progression of PBC, and this miRNA may represent a novel target of improved diagnostic and preventive strategies for PBC. | 24074714 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | A prognostic DNA methylation signature for stage I non-small-cell lung cancer. | 24081945 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | A DNA methylation microarray that analyzes 450,000 CpG sites was used to study tumoral DNA obtained from 444 patients with NSCLC that included 237 stage I tumors. | 24081945 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The prognostic DNA methylation markers were validated by a single-methylation pyrosequencing assay in an independent cohort of 143 patients with stage I NSCLC. | 24081945 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Unsupervised clustering of the 10,000 most variable DNA methylation sites in the discovery cohort identified patients with high-risk stage I NSCLC who had shorter relapse-free survival (RFS; hazard ratio [HR], 2.35; 95% CI, 1.29 to 4.28; P = .004). | 24081945 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The DNA methylation signature of NSCLC affects the outcome of stage I patients, and it can be practically determined by user-friendly polymerase chain reaction assays. | 24081945 |
| Hypertrophic Cardiomyopathy | Epigenetic Alterations | MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations. | 24083979 |
| Health maintenance | Epigenetic Alterations | To determine which miRNAs were changed in expression, miRNA arrays were performed on heart tissue from HCM patients with a MYBPC3 mutation (n=6) and compared with hearts of non-failing donors (n=6). | 24083979 |
| Health maintenance | Epigenetic Alterations | HCM patients with MYBPC3 mutations have a specific miRNA expression profile. | 24083979 |
| Health maintenance | Epigenetic Alterations | 13 miRNAs were differentially expressed in HCM compared with donors (at p<0.01, fold change >= 2). | 24083979 |
| Health maintenance | Epigenetic Alterations | The genomic context of these differentially expressed miRNAs revealed that miR-204 (fold change 2.4 in HCM vs. donor) was located in an intron of the TRPM3 gene, encoding an aspecific cation channel involved in calcium entry. | 24083979 |
| Health maintenance, Cardiac Hypertrophy | Epigenetic Alterations | In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. | 24083979 |
| Breast Carcinoma | Epigenetic Alterations | Identification of breast cancer DNA methylation markers optimized for fine-needle aspiration samples. | 24089458 |
| Breast Carcinoma | Epigenetic Alterations | Unbiased whole-genome 5-aza-2-deoxycytidine (5AZA)-induced gene expression assays, followed by several phases of qualitative and quantitative methylation-specific PCR (MSP) testing, were used to identify novel breast cancer DNA methylation markers optimized for clinical FNA samples. | 24089458 |
| Hepatitis B | Epigenetic Alterations | Hepatitis B virus inhibits apoptosis of hepatoma cells by sponging the MicroRNA 15a/16 cluster. | 24089558 |
| Metabolic Syndrome X | Epigenetic Alterations | Circulating microRNAs have a sex-specific association with metabolic syndrome. | 24093444 |
| ETV3 wt Allele | Epigenetic Alterations | In the female subjects, increased expression of both microRNAs was associated with an increased number of MetS risk components (p = 0.002 for let-7 g and p = 0.022 for miR-221). | 24093444 |
| Disorder of skeletal system | Epigenetic Alterations | Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders. | 24096177 |
| Stomach Carcinoma | Epigenetic Alterations | Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer. | 24097871 |
| Chronic Kidney Diseases | Epigenetic Alterations | Our report raises the possibility that epigenetic dysregulation plays a role in chronic kidney disease development via influencing core pro-fibrotic pathways and can aid the development of novel biomarkers and future therapeutics. | 24098934 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | We previously identified a panel of epigenetic biomarkers (GDF15, TMEFF2 and VIM promoter methylation) that accurately identifies bladder cancer in urine. | 24100025 |
| Admitting diagnosis | Epigenetic Alterations | Our results provide a link between familial AD genes and sporadic neuropathology, thus emphasizing an epigenetic pathomechanism for sporadic AD. | 24101602 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We quantified miRNA-21 and miRNA-486 expression from plasma and EBC samples from patients with a diagnosis of non-small-cell lung cancer (NSCLC) and controls. | 24102090 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA-21 was significantly higher in plasma and in EBC of the NSCLC patients and miRNA-486 was significantly lower. | 24102090 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Plasma and EBC microRNAs as early biomarkers of non-small-cell lung cancer. | 24102090 |
| Primary malignant neoplasm | Epigenetic Alterations | Micro RNAs have called great attention for classification of different cancer types and have been implicated in a range of important biological processes and are deregulated in cancer pathogenesis. | 24104964 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Many micro-RNAs (miRNAs) are differentially expressed in Helicobacter pylori-infected gastric mucosa and in gastric cancer tissue and previous reports have suggested the possibility of serum miRNAs as complementary tumour markers. | 24104965 |
| Malignant Neoplasms | Epigenetic Alterations | Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be related with susceptibility to several human cancers. | 24107911 |
| Wounds and Injuries | Epigenetic Alterations | Identification of a miRNA signature in neutrophils after traumatic injury. | 24108763 |
| Wounds and Injuries | Epigenetic Alterations | However, the association between miRNA deregulation and traumatic injury is largely unknown. | 24108763 |
| Traumatic injury | Epigenetic Alterations | Results showed that 13 miRNAs in neutrophils of major trauma patients were significantly and differentially expressed compared with the miRNA profiles of healthy controls. | 24108763 |
| Wounds and Injuries | Epigenetic Alterations | In conclusion, neutrophils associated with traumatic injury were found to have a unique miRNA signature. | 24108763 |
| Wounds and Injuries | Epigenetic Alterations | The molecular mechanisms underlying traumatic injury logically involve changes in gene expression that may be regulated through microRNAs (miRNAs). | 24108763 |
| Wounds and Injuries | Epigenetic Alterations | Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury. | 24108763 |
| Colorectal Neoplasms | Epigenetic Alterations | The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia. | 24108782 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Decreased genomic and increased gene-specific DNA methylation predispose to colorectal cancer. | 24108782 |
| Carcinoma of lung | Epigenetic Alterations | Here we developed and validated a prediction algorithm based on microRNA (miRNA) expression that can assist clinical diagnosis of lung cancer in minimal biopsy material to improve clinical management. | 24113142 |
| Prostate Cancer Pathway | Epigenetic Alterations | Whole-genome methylation sequencing reveals distinct impact of differential methylations on gene transcription in prostate cancer. | 24113458 |
| Liver carcinoma | Epigenetic Alterations | Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. | 24114970 |
| Hollings Cancer Center | Epigenetic Alterations | Recent evidence highlighted long noncoding RNAs (lncRNAs) as crucial determinants of HCC development. | 24114970 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetic priming of AML blasts for all-trans retinoic acid-induced differentiation by the HDAC class-I selective inhibitor entinostat. | 24116031 |
| Autoimmune Diseases, Lupus Erythematosus | Epigenetic Alterations | Epigenetic deregulation of genes encoded on the X chromosome as reported for CD40L in lupus could explain the female predominance of autoimmune diseases. | 24117612 |
| Inflammation, Neoplasms | Epigenetic Alterations | MicroRNA-218 (miR-218) can function as a tumour suppressor and inactivate cancer-promoting inflammation. | 24118778 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Plasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first-line oxaliplatin-based treatment. | 24119443 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Increased expression of microRNA-9 predicts an unfavorable prognosis in human glioma. | 24122417 |
| Glioma, Neoplasms, Glioblastoma Multiforme | Epigenetic Alterations | microRNA-9 (miR-9) has been found to be upregulated along with tumor progression of gliomas by microarray-based expression profiling, and also be strongly linked to glioblastoma subtypes. | 24122417 |
| Stomach Carcinoma, MIR20A gene | Epigenetic Alterations | We previously identified five miRNAs (miR-1, miR-20a, miR-27a, miR-34a, and miR-423-5p) that are up-regulated in gastric cancer. | 24122958 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The relationship between and clinical significance of MicroRNA-32 and phosphatase and tensin homologue expression in colorectal cancer. | 24123284 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs, miRs) are suspected to play important roles in carcinogenesis. | 24123284 |
| Liver carcinoma | Epigenetic Alterations | [Expression of serum microRNAs (miR-222, miR-181, miR-216) in human hepatocellular carcinoma and its clinical significance]. | 24124720 |
| Prostate Cancer Pathway | Epigenetic Alterations | Prostate cancer cells exposed to epigenetic modifying drugs trichostatin A, alone or combined with 5-aza-2-deoxycytidine, increased H2AFZ transcript, although with a concomitant decrease in protein levels. | 24127549 |
| Prostate Cancer Pathway | Epigenetic Alterations | Epigenetic modifying drugs in conjunction with enzymatic modulators are able to restore the normal functions of sirtuin 1 and might constitute relevant tools for targeted therapy of prostate cancer patients. | 24127549 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | The specific modification of microRNAs (miRNAs) expression could be a promising strategy in breast cancer therapy, leading to the suppression of tumourigenic processes in tumour cells. | 24129242 |
| Breast Carcinoma | Epigenetic Alterations | Considering that miR-221/-222 are strongly involved in cell invasion, these miRNAs may be promising markers for breast cancer prognosis and therapy. | 24129242 |
| Kidney Neoplasm | Epigenetic Alterations | MicroRNA profile: a promising ancillary tool for accurate renal cell tumour diagnosis. | 24129247 |
| Adenocarcinoma of lung, stage I | Epigenetic Alterations | Epigenetic inactivation of miR-34b/c by DNA methylation has independent prognostic value in patients with early-stage lung adenocarcinoma. | 24130071 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Epigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma. | 24130071 |
| Neoplasms | Epigenetic Alterations | The microRNA-34b/c (miR-34b/c) is considered a tumor suppressor in different tumor types and a transcriptional target of TP53. | 24130071 |
| Primary malignant neoplasm | Epigenetic Alterations | Global decrease in DNA methylation is a common feature of cancer and is associated with genomic and chromosomal instability. | 24130171 |
| Squamous cell carcinoma of lung, Neoplasms | Epigenetic Alterations | Comparisons of microRNA patterns in plasma before and after tumor removal reveal new biomarkers of lung squamous cell carcinoma. | 24130905 |
| Carcinoma of lung | Epigenetic Alterations | However, results of multiple previous attempts to identify circulating miRNAs specific for lung cancer are inconsistent, likely due to two main reasons: prominent variability in blood miRNA content among individuals and difficulties in distinguishing tumor-relevant miRNAs in the blood from their non-tumor counterparts. | 24130905 |
| Squamous cell carcinoma of lung, Neoplasms | Epigenetic Alterations | To overcome these impediments, we compared circulating miRNA profiles in patients with lung squamous cell carcinoma (SCC) before and after tumor removal, assuming that the levels of all tumor-relevant miRNAs would drop after the surgery. | 24130905 |
| Carcinoma of lung | Epigenetic Alterations | Interestingly, miRNA profiling of plasma fractions of lung SCC patients revealed high levels of these miRNA species in tumor-specific exosomes; additionally, some of these miRNAs were also found to be selectively secreted to the medium by cultivated lung cancer cells. | 24130905 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | These results strengthen the notion that tumor cells secrete miRNA-containing exosomes into circulation, and that miRNA profiling of the exosomal plasma fraction may reveal powerful cancer biomarkers. | 24130905 |
| Asthma Pathway | Epigenetic Alterations | DNA methylation in the ADRB2 gene is associated with decreased asthma symptom severity, suggesting a role for methylation in asthma phenotypes. | 24131275 |
| Asthma Pathway | Epigenetic Alterations | Epigenetic variation in the ADRB2 may play an important role in asthma phenotype. | 24131275 |
| Neoplasms | Epigenetic Alterations | The CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) gene is a novel tumor suppressor with frequent epigenetic inactivation. | 24131472 |
| Primary malignant neoplasm | Epigenetic Alterations | We found that CMTM3 expression was reduced or silenced by epigenetic regulation in gastric cell lines, and dramatically downregulated in primary gastric cancer tissues. | 24131472 |
| Primary malignant neoplasm | Epigenetic Alterations | The disease has endemic distribution in the Danube river regions in several Balkan countries.DNA methylation is a primary epigenetic modification that is involved in major processes such as cancer, genomic imprinting, gene silencing, etc. | 24131581 |
| Neoplasms | Epigenetic Alterations | MicroRNA miR-124 has been suggested as a tumor suppressor for its role in inhibiting cell growth, inducing differentiation and promoting apoptosis. | 24135052 |
| Bile Duct Neoplasms, Liver carcinoma | Epigenetic Alterations | Expression profile of microRNA-200 family in hepatocellular carcinoma with bile duct tumor thrombus. | 24135722 |
| Metastasis, Hollings Cancer Center | Epigenetic Alterations | Epithelial-to-mesenchymal transition (EMT) is considered a critical step in the progression and metastasis of HCC and is regulated by the microRNA-200 (miR-200) family. | 24135722 |
| Neoplasms | Epigenetic Alterations | Specific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours. | 24136150 |
| Pleural effusion disorder, Neoplasms | Epigenetic Alterations | SHOX2 DNA methylation is a tumour marker in pleural effusions. | 24136974 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Aberrant expression of microRNAs in chronic lymphocytic leukemia (CLL) has been reported to be associated with clinical outcome and improve prognostic stratification. | 24138306 |
| Neoplasms | Epigenetic Alterations | Dysregulation of microRNA let-7a-3 has been identified in several solid tumors and is associated with prognosis of patients. | 24138945 |
| Albuminuria | Epigenetic Alterations | Downregulation of Sirt1 and upregulation of the tight junction protein Claudin-1 by SIRT1-mediated epigenetic regulation in podocytes contributed to albuminuria. | 24141423 |
| Cervical Squamous Cell Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma. | 24141696 |
| Malignant Neoplasms | Epigenetic Alterations | Our recent studies of microRNA (miRNA) expression signatures indicated that microRNA-29a (miR-29a) was significantly downregulated in several types of human cancers, suggesting that miR-29a may be a putative tumor-suppressive miRNA in human cancers. | 24141696 |
| cervical cancer, Primary malignant neoplasm | Epigenetic Alterations | Restoration of miR-29a in cervical cancer cell lines (CaSKi, HeLa, ME180 and Yumoto) revealed that this miRNA significantly inhibited cancer cell migration and invasion. | 24141696 |
| Metastasis | Epigenetic Alterations | Recognition of tumor-suppressive miRNA-regulated molecular targets provides new insights into the potential mechanisms of cervical SCC oncogenesis and metastasis and suggests novel therapeutic strategies for treatment of this disease. | 24141696 |
| Malignant Neoplasms, Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Increasing epidemiological evidence has indicated that inherited variations of mitochondrial DNA (mtDNA) copy number affect the genetic susceptibility of many malignancies in a tumour-specific manner and that DNA methylation also plays an important role in controlling gene expression during the differentiation and development of hepatocellular carcinoma (HCC). | 24143196 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRs) play important roles in the development and progression of human cancers. | 24144839 |
| Carcinogenesis, Primary malignant neoplasm, Ovarian Carcinoma, Neoplasms | Epigenetic Alterations | Altered DNA methylation of tumor suppressor gene promoters probably plays a relevant role in ovarian carcinogenesis and frequently occurs as an early event in the development of different types of cancer including ovarian carcinoma. | 24145767 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Genetic variation in a microRNA-502 minding site in SET8 gene confers clinical outcome of non-small cell lung cancer in a Chinese population. | 24146953 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our data suggested that the rs16917496 T>C located at miR-502 binding site contributes to NSCLC survival by altering SET8 expression through modulating miRNA-target interaction. | 24146953 |
| Hollings Cancer Center | Epigenetic Alterations | DNA methylation directed repression of BTG3 mRNA expression in HCC cell lines. | 24147003 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Overexpression of microRNA-183 in human colorectal cancer and its clinical significance. | 24150523 |
| Malignant tumor of colon | Epigenetic Alterations | MicroRNA-183 (miR-183) has been shown to play a potential oncogenic role in colon cancer. | 24150523 |
| Lymphoma | Epigenetic Alterations | FLIS and PFL had no or few secondary chromosomal imbalances detectable by array comparative genomic hybridization (FLIS 0.8 copy number alterations (CNA)/case; PFL 2.0 CNA/case; mFL 6.3 CNA/case) and a lower level of DNA methylation of genes recurrently de novo methylated in lymphomas, as compared with mFL. | 24153014 |
| Squamous cell carcinoma | Epigenetic Alterations | DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma. | 24155659 |
| SERPINB3 wt Allele | Epigenetic Alterations | DNA methylation profiling was utilized to screen the differentially hypermethylated genes in OSCC. | 24155659 |
| Admitting diagnosis | Epigenetic Alterations | Our results provide a possibility that miRNAs detected in plasma and CSF can serve as biomarkers for AD. | 24157723 |
| Primary malignant neoplasm | Epigenetic Alterations | Additionally, one new miRNA-like molecule with a potential role in cancer was identified in the cell lines and clinical samples. | 24160351 |
| Squamous cell carcinoma | Epigenetic Alterations | High-throughput sequencing of small RNA transcriptomes reveals critical biological features targeted by microRNAs in cell models used for squamous cell cancer research. | 24160351 |
| Disease | Epigenetic Alterations | The implication of post-transcriptional regulation by microRNAs in molecular mechanisms underlying cancer disease is well documented. | 24160351 |
| Usher Syndrome | Epigenetic Alterations | Our results indicate that mutations in the USH2A gene and the resulting phenotype are probably modulated by other variables, such as modifying genes, epigenetics or environmental factors which may be of importance for better understanding the etiology of Usher syndrome. | 24160897 |
| Neoplasms | Epigenetic Alterations | Our findings confirm frequent presence of certain aberrations and reveal novel candidates for improving prognosis based on genetic and epigenetic tumor features. | 24162828 |
| Alzheimers Disease", Loading Technique | Epigenetic Alterations | Alterations in DNA methylation have implicated as an epigenetic event in the pathogenesis of late-onset Alzheimers disease (LOAD). | 24164934 |
| Asthma Pathway | Epigenetic Alterations | Aberrant epigenetic modifications, such as DNA methylation, may be important in asthma development. | 24166889 |
| Asthma Pathway | Epigenetic Alterations | Fetal exposure to maternal asthma during critical periods of in utero development may lead to epigenetic alterations that predispose infants to a greater risk of developing asthma themselves. | 24166889 |
| Prostate Cancer Pathway | Epigenetic Alterations | MicroRNA profiling in prostate cancer--the diagnostic potential of urinary miR-205 and miR-214. | 24167554 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | ROC curve shows that all four miRNAs successfully discriminated between PCa and adjacent normal tissues. | 24167554 |
| Myocardial fibrosis, Aortic Valve Stenosis | Epigenetic Alterations | microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-b1 up-regulation. | 24168656 |
| 1-methyl-1-piperidinomethane sulfonate | Epigenetic Alterations | microRNA-34b/c (miR-34b/c), which plays an important role in the pathogenesis of MPM, is frequently downregulated by DNA methylation in approximately 90% of MPM cases. | 24168922 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma. | 24168922 |
| Breast Carcinoma | Epigenetic Alterations | Differences in DNA methylation by extent of breast cancer family history in unaffected women. | 24172832 |
| Breast Carcinoma | Epigenetic Alterations | Lower global DNA methylation in white blood cells (WBC) has been associated with increased breast cancer risk. | 24172832 |
| Breast Carcinoma | Epigenetic Alterations | We examined whether WBC DNA methylation varies by extent of breast cancer family history in unaffected women from high-risk breast cancer families. | 24172832 |
| Breast Carcinoma | Epigenetic Alterations | We used generalized estimated equation models to test for differences in DNA methylation levels by extent of their breast cancer family history after adjusting for age. | 24172832 |
| Breast Carcinoma | Epigenetic Alterations | LINE-1 and Sat2 DNA methylation levels were lower in individuals with 3 or more (3+) first-degree relatives with breast cancer relative to women with only one first-degree relative. | 24172832 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | If replicated, these results indicate that lower global WBC DNA methylation levels in families with extensive cancer histories may be one explanation for the clustering of cancers in these families. | 24172832 |
| Intervertebral Disc Degeneration | Epigenetic Alterations | Characterization of microRNA expression profiles in patients with intervertebral disc degeneration. | 24173697 |
| Intervertebral disc disorder | Epigenetic Alterations | Our results demonstrated that the miRNA expression in patients with IDD differed significantly from that in patients who sustained injury to the intervertebral disc. | 24173697 |
| Intervertebral disc disorder | Epigenetic Alterations | Further studies on miRNA target gene identification and biological functions may address the specific regulatory mechanisms of miRNAs in IDD, and may provide valuable insight into the diagnosis and treatment of IDD. | 24173697 |
| Disorder of male reproductive system | Epigenetic Alterations | Accumulating evidence has indicasted that newly defined gene regulators, microRNAs (miRNAs), play a vital role in neurodegenerative, pathophysiological and certain reproductive disorders. | 24173697 |
| Intervertebral disc disorder, Spinal Cord Injuries | Epigenetic Alterations | Among the miRNAs analyzed, 25 miRNAs were found to be upregulated and 26 were found to be downregulated in the IDD group compared with the spinal cord injury group. | 24173697 |
| Intervertebral disc disorder | Epigenetic Alterations | Our data indicate that the dysregulated miRNAs control the signaling pathways important for the maintenance of IDD. | 24173697 |
| Esophageal carcinoma | Epigenetic Alterations | Involvement of microRNA-198 overexpression in the poor prognosis of esophageal cancer. | 24175778 |
| Esophageal carcinoma | Epigenetic Alterations | MicroRNA was extracted from esophageal cancer patients who underwent surgery for assessment using the Taqman@ MicroRNA assay. | 24175778 |
| ovarian neoplasm | Epigenetic Alterations | Epigenetic and expression analysis of TRAIL-R2 and BCL2: on the TRAIL to knowledge of apoptosis in ovarian tumors. | 24190693 |
| Prostate Cancer Pathway | Epigenetic Alterations | Our findings showed Chinese prostate cancer patients have a common and specific miRNA expression profile compared with non-Chinese populations. | 24191917 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | A total of 28 miRNAs (fold change >= 1.5; P <= 0.05) were differentially expressed between tumor tissue and adjacent benign tissue of 4 prostate cancer patients.10 top Differentially expressed miRNAs were validated by qRT-PCR using all 20 tissue pairs. | 24191917 |
| Malignant Glioma, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Here, we used an integrated approach to identify miRNA functional targets during glioma malignant progression by combining the paired expression profiles of miRNAs and mRNAs across 160 Chinese glioma patients, and further constructed the functional miRNA-mRNA regulatory network. | 24194606 |
| Glioblastoma Multiforme Pathway, Neoplasms, Malignant Glioma | Epigenetic Alterations | Glioma is the most common and fatal primary brain tumour with poor prognosis; however, the functional roles of miRNAs in glioma malignant progression are insufficiently understood. | 24194606 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | As a result, most tumour-suppressive miRNAs in glioma progression were newly discovered, whose functions were widely involved in gliomagenesis. | 24194606 |
| Colorectal Carcinoma | Epigenetic Alterations | MicroRNA-191 correlates with poor prognosis of colorectal carcinoma and plays multiple roles by targeting tissue inhibitor of metalloprotease 3. | 24195505 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | MicroRNA-191 (miR-191) is reported to be overexpressed in colorectal carcinoma (CRC), but the role of miR-191 in CRC progress remained unclear. | 24195505 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer. | 24195777 |
| Breast Carcinoma, Mammary Neoplasms | Epigenetic Alterations | Age is a key risk factor for breast cancer and epigenetic alterations may contribute to age-related increases in breast cancer risk, though the relation of age-related methylation in normal breast tissues with altered methylation in breast tumors is unclear. | 24196486 |
| Cessation of life, Fibrosis Assessment | Epigenetic Alterations | The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development. | 24196965 |
| fibrogenesis | Epigenetic Alterations | Recently, microRNA-21 (miR-21) has been found to be prevalently up-regulated during fibrogenesis in different tissues, although its detailed role needs to be further elucidated. | 24196965 |
| Kidney Diseases | Epigenetic Alterations | MicroRNAs (miRNAs), a family of endogenous small non-coding RNAs, are associated with the development of renal diseases. | 24198052 |
| Kidney Diseases | Epigenetic Alterations | We observed 80-99 % of the miRNAs in both the healthy controls and the renal disease patients. | 24198052 |
| Kidney Diseases | Epigenetic Alterations | The majority of UmiRNAs displayed higher signal intensity in renal disease patients than in healthy controls, including 39 miRNAs exhibiting signal intensities 100 times greater than in healthy controls. | 24198052 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Adverse prognostic value of MYBL2 overexpression and association with microRNA-30 family in acute myeloid leukemia patients. | 24199710 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Prostate cancer (PCa), a leading cause of cancer-related morbidity and mortality, arises through the acquisition of genetic and epigenetic alterations. | 24200674 |
| Inflammation | Epigenetic Alterations | Histone acetylation at promoter and enhancer chromosomal regions opens the chromatin and allows access of transcription enzymes to specific genes in rapid response cell signals, such as in inflammation. | 24204704 |
| diabetic | Epigenetic Alterations | Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes. | 24204704 |
| Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Epigenetic Alterations | Unstimulated (p = 0.140) and GM-CSF-stimulated (p = 0.0485) T1D monocytes, had greater STAT5Ptyr binding to epigenetic regulatory sites upstream of CSF2 than control monocytes. | 24204704 |
| Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Epigenetic Alterations | These findings suggest that the persistent activation of STAT5 by GM-CSF may be involved in altering the epigenetic regulation of these inflammatory response genes in T1D monocytes. | 24204704 |
| Primary malignant neoplasm | Epigenetic Alterations | A key epigenetic alteration involved in the initiation and progression of cancer is aberrant methylation in the promoter region of a gene. | 24204800 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | MicroRNA expression profile in head and neck cancer: HOX-cluster embedded microRNA-196a and microRNA-10b dysregulation implicated in cell proliferation. | 24209638 |
| Malignant Neoplasms | Epigenetic Alterations | Current evidence implicates aberrant microRNA expression patterns in human malignancies; measurement of microRNA expression may have diagnostic and prognostic applications. | 24209638 |
| Squamous cell carcinoma | Epigenetic Alterations | MicroRNA expression profile of oral squamous cell carcinoma samples was determined by means of DNA microarrays. | 24209638 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | Roles for microRNAs in head and neck squamous cell carcinomas (HNSCC) are largely unknown. | 24209638 |
| Carcinoma of lung | Epigenetic Alterations | Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells. | 24211326 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA-449a (miR-449a) was significantly downregulated in 156 lung cancer tissues (p<0.001). | 24211326 |
| teratologic, Colorectal Carcinoma | Epigenetic Alterations | Subgroups of colorectal carcinomas (CRCs) characterized by DNA methylation anomalies are termed CpG island methylator phenotype (CIMP)1, CIMP2, or CIMP-negative. | 24211491 |
| Neoplasms | Epigenetic Alterations | A better understanding of the biological determinants of CRCs can be achieved when these tumors are categorized according to their epigenetic status. | 24211491 |
| Malignant Neoplasms | Epigenetic Alterations | Recent reports suggest that circulating microRNAs (miRNAs) have great potential as biomarkers for diagnosis and prognosis in patients with several types of cancers. | 24212760 |
| Malnutrition | Epigenetic Alterations | The bone porosity was probably caused by malnutrition that might have had a beneficial effect on longevity of adults, similar to effects of restricted food intake on extending lifespan through epigenetic signatures influencing gene expression. | 24219154 |
| Neoplasms | Epigenetic Alterations | miR-21, a putative tumor oncomiR, is a frequently overexpressed miRNA in a variety of tumors. | 24221338 |
| Breast Carcinoma | Epigenetic Alterations | Identification of androgen-responsive microRNAs and androgen-related genes in breast cancer. | 24222117 |
| Neoplasms, Hormone-Dependent | Epigenetic Alterations | The study of microRNAs has recently provided with important insights into the biology of hormone-dependent cancer. | 24222117 |
| Breast Carcinoma | Epigenetic Alterations | We examined a possible correlation among microRNAs, target genes, and ARs in breast cancer tissues using immunohistochemistry and laser capture microscopy. | 24222117 |
| Primary malignant neoplasm | Epigenetic Alterations | Although microRNAs (miRNA) show potential as diagnostic biomarkers in cancer, their role as circulating cell-free disease response biomarkers remains unknown. | 24222179 |
| Hodgkin Disease | Epigenetic Alterations | Candidate circulating miRNA biomarkers for classical Hodgkin lymphoma (cHL) might arise from Hodgkin-Reed-Sternberg (HRS) cells and/or nonmalignant tumor-infiltrating cells. | 24222179 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA and protein expression patterns were compared between gastric cancer tissue and normal gastric tissue and between two different prognostic groups. | 24222951 |
| Stomach Carcinoma | Epigenetic Alterations | Array technologies were used to generate 1146 microRNAs and 124 proteins expression profiles of samples from 60 patients with gastric cancer. | 24222951 |
| Non-Cancer Related Death, Primary malignant neoplasm | Epigenetic Alterations | Four microRNAs were aberrantly expressed in the two prognostic groups and in cancer vs non-cancer tissues (P < 0.05). | 24222951 |
| Rheumatoid Arthritis, Neoplasms | Epigenetic Alterations | The methylation status of miR-124a seen in this study concurs with that reported in tumor cells, indicating epigenetic dysregulation constituents, a mechanism in the development of rheumatoid arthritis. | 24223605 |
| ovarian neoplasm | Epigenetic Alterations | Plasma miRNAs as diagnostic and prognostic biomarkers for ovarian cancer. | 24223734 |
| Amyotrophic Lateral Sclerosis | Epigenetic Alterations | Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset. | 24224837 |
| methionine, Antilymphocyte Serum | Epigenetic Alterations | In conclusion, increased DNA MET % is a possible marker of epigenetic dysfunction in ALS independently of age of onset. | 24224837 |
| Ovarian Carcinoma | Epigenetic Alterations | We suggest that SAHA may suppress growth, migration and invasion in ovarian carcinoma cells, including cisplatin-resistant or highly-invasive ovarian cells, by promoting histone acetylation and modulating their phenotype-related molecules. | 24236158 |
| Ischemic stroke | Epigenetic Alterations | However, the knowledge on the association of plasma miRNAs with ischemic stroke is still lacking. | 24237608 |
| Anus Neoplasms | Epigenetic Alterations | Total miRNA was extracted from serum samples in patients with malignant and benign adrenal neoplasms. | 24238045 |
| SERPINB3 wt Allele | Epigenetic Alterations | The up-regulated level of microRNA-31 expression may be related to the pathogenesis of OSCC. | 24238414 |
| Periapical Diseases | Epigenetic Alterations | MicroRNAs: new insights into the pathogenesis of endodontic periapical disease. | 24238436 |
| Periapical Diseases, Inflammation | Epigenetic Alterations | MicroRNAs (miRNAs) have been shown to play an important role in the regulation of inflammation and the immune response; however, their role in the pathogenesis of endodontic periapical disease has not been explored. | 24238436 |
| Carcinoma of larynx | Epigenetic Alterations | Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data. | 24238754 |
| Carcinoma of larynx | Epigenetic Alterations | These two candidate miRNA biomarkers were combined as a single classifier to recognize the biological characteristics in early larynx carcinoma. | 24238754 |
| Laryngeal neoplasm | Epigenetic Alterations | We identified 47 miRNAs that were significantly differentially expressed in primary larynx tumor tissues compared to normal tissues using a SAM algorithm. | 24238754 |
| Malignant tumor of colon | Epigenetic Alterations | Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis. | 24239208 |
| Stage II Colon Cancer AJCC v7, Neoplasms | Epigenetic Alterations | Using miRNA microarrays, we analysed 40 paired stage II colon cancer tumours and adjacent normal mucosa tissues, and identified 35 miRNAs that were differentially expressed between tumours and normal tissue. | 24239208 |
| Malignant tumor of colon | Epigenetic Alterations | We developed two nomograms for clinical use that integrated the six-miRNA-based classifier and four clinicopathological risk factors to predict which patients might benefit from adjuvant chemotherapy after surgery for stage II colon cancer. | 24239208 |
| Stage II Colon Cancer AJCC v7 | Epigenetic Alterations | Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer, and might be able to predict which patients benefit from adjuvant chemotherapy. | 24239208 |
| Stage II Colon Cancer AJCC v7 | Epigenetic Alterations | Using paraffin-embedded specimens from a further 138 patients with stage II colon cancer, we confirmed differential expression of these miRNAs using qRT-PCR. | 24239208 |
| Multiple Myeloma, Gammopathy | Epigenetic Alterations | Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. | 24241494 |
| Multiple Myeloma, Gammopathy | Epigenetic Alterations | Emerging evidence has suggested that circulating microRNAs can serve as minimally invasive biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. | 24241494 |
| Multiple Myeloma, Gammopathy | Epigenetic Alterations | Median time of remission for both miR-744 and let-7e was approximately 11 months for the low expression and approximately 47 months for the high expression groups of myeloma patients These data demonstrate that expression patterns of circulating microRNAs are altered in multiple myeloma and monoclonal gammopathy of undetermined significance and miR-744 with let-7e are associated with survival of myeloma patients. | 24241494 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway. | 24242331 |
| Malignant Neoplasms | Epigenetic Alterations | Although microRNAs (miRNAs) are useful biomarkers of various cancers, the association between miRNA and BRAF in CRCs is undefined. | 24242331 |
| Serrated Nodule | Epigenetic Alterations | Therefore, this study was conducted to identify a relationship between specific miRNA molecules and BRAF mutation in CRCs and serrated lesions. | 24242331 |
| Adenoma | Epigenetic Alterations | To assess the identified miRNAs, quantitative reverse transcription-PCR was performed on 721 CRCs, 381 serrated lesions and 251 non-serrated adenomas. | 24242331 |
| Secondary malignant neoplasm of lung | Epigenetic Alterations | A miRNA signature distinguished lung metastases from other metastatic sites. | 24242678 |
| Primary Neoplasm, Conventional (Clear Cell) Renal Cell Carcinoma, Metastasis | Epigenetic Alterations | MicroRNAs with prognostic potential for metastasis in clear cell renal cell carcinoma: a comparison of primary tumors and distant metastases. | 24242678 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are regulators of gene expression in tumor development and progression. | 24242678 |
| Neoplasms | Epigenetic Alterations | There were 14 miRNAs differently expressed in metastatic primary ccRCC and distant metastases compared to non-metastatic primary tumors. | 24242678 |
| Metastasis | Epigenetic Alterations | MiRNAs are deregulated in metastatic primary ccRCC and could be promising prognostic markers for an early prediction of metastasis. | 24242678 |
| Neoplasms | Epigenetic Alterations | However, there is limited understanding regarding the molecular mechanisms of altered methylation, and whether the tumor microenvironment has any effect on DNA methylation and IFNG production. | 24244422 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Development of colorectal cancer (CRC) can occur both via gene mutations in tumor suppressor genes and oncogenes, as well as via epigenetic changes, including DNA methylation. | 24244575 |
| Metabolic Diseases | Epigenetic Alterations | Restoring Dicer levels and the diurnal patterns of Dicer-controlled miRNA and RNA expression may provide new therapeutic strategies for metabolic disease and aging-associated complications. | 24244599 |
| Pseudolymphoma | Epigenetic Alterations | Eight miRNAs showed statistically significant difference in expression between PTCL-NOS and reactive lymphoid hyperplasia. | 24246916 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) are emerging as key molecules in human cancer. | 24247585 |
| Malignant Neoplasms | Epigenetic Alterations | Single nucleotide polymorphisms (SNPs) in microRNA (miR)-196a-2 have been suggested to contribute to susceptibility to various human cancers. | 24248733 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1/caspase-9 apoptotic pathway in colorectal cancer cells. | 24249161 |
| Neoplasms | Epigenetic Alterations | Current literature provided information that alteration in microRNA expression impacted sensitivity or resistance of certain tumor types to anticancer treatment, including the possible intracellular pathways. | 24249161 |
| Progranulins, Frontotemporal Lobar Degeneration | Epigenetic Alterations | Promoter DNA methylation regulates progranulin expression and is altered in FTLD. | 24252647 |
| Frontotemporal Lobar Degeneration | Epigenetic Alterations | We analyzed whether DNA methylation in the GRN core promoter restricts GRN expression and, thus, might promote FTLD in the absence of GRN mutations. | 24252647 |
| Frontotemporal Lobar Degeneration | Epigenetic Alterations | These data suggest that altered DNA methylation is a novel pathomechanism for FTLD that is potentially amenable to targeted pharmacotherapy. | 24252647 |
| Metastasis, Neoplasms | Epigenetic Alterations | DNA methylation contributes to tumor formation, development and metastasis. | 24256813 |
| Primary malignant neoplasm | Epigenetic Alterations | qRT-PCR, quantitative methylation-specific PCR (qMSP) and pyrosequencing were used to verify gene expression and DNA methylation in cancer cell lines. | 24256813 |
| Disease | Epigenetic Alterations | Growing evidences show that the pathogenesis of majority human diseases is influenced by the abnormalities of epigenetic and genetic mechanism. | 24257350 |
| Malignant Neoplasms, Breast, Malignant neoplasm of liver | Epigenetic Alterations | Expression of HOX transcript antisense intergenic RNA (HOTAIR)--a long non-coding RNA--has been examined in a variety of human cancers, and overexpression of HOTAIR is correlated with poor survival among breast, colon, and liver cancer patients. | 24258260 |
| Angina, Unstable | Epigenetic Alterations | Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina. | 24260372 |
| Thymoma, Neoplasms | Epigenetic Alterations | Moreover, epithelial tumours (thymomas) are present in about 10-20% of the patients, and there is indication that changes in DNA methylation might contribute to the risk and progression of thymomas. | 24260492 |
| Primary malignant neoplasm, Autoimmune state | Epigenetic Alterations | Increasing evidence suggests a contribution of epigenetic processes in promoting cancer and autoimmunity. | 24260492 |
| Primary malignant neoplasm | Epigenetic Alterations | Let-7 microRNAs (miRNAs) are found in a wide range of species, and alterations of let-7 miRNA family member expression levels in humans are associated with various types of cancer. | 24264599 |
| Breast Diseases, babaodan capsule | Epigenetic Alterations | We utilized digoxigenin-labeled locked nucleic acid-miRNA probes to detect let-7b expression in 80 BC and 22 benign breast disease (BBD) histologic specimens by in situ hybridization, and also detect the expression of BSG-a potential target gene of let-7b-by immunohistochemistry. | 24264599 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | We detected thousands of transcriptional elements differentially expressed between the CLL and normal B cells, including protein-coding genes, noncoding RNAs, and pseudogenes. | 24265505 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. | 24265601 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of cancer. | 24265601 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure. | 24268366 |
| Degenerative polyarthritis | Epigenetic Alterations | OA chondrocytes were transfected with a miRNA precursor for hsa-miR-148a or a miRNA precursor negative control. | 24269634 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | Epigenetic inactivation of SPINT2 is associated with tumor suppressive function in esophageal squamous cell carcinoma. | 24269829 |
| Malignant Neoplasms | Epigenetic Alterations | Growing evidence has indicated the important roles for different miRNA species in the development of different cancers. | 24272087 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Differential expression profiling of microRNAs and their potential involvement in esophageal squamous cell carcinoma. | 24272087 |
| Hollings Cancer Center | Epigenetic Alterations | Arsenic resistance protein 2 (Asr2) was reported to be important for microRNA (miR) biogenesis, and its depletion could reduce the levels of several miRs, including miR-21, which is over-expressed in HCC. | 24272391 |
| Colorectal Cancer Pathway | Epigenetic Alterations | A DNA methylation microarray was used to identify epigenetic differences in oxaliplatin-sensitive and -resistant colorectal cancer cells. | 24273214 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We found that oxaliplatin resistance in colorectal cancer cells depends on the DNA methylation-associated inactivation of the BRCA1 interactor SRBC gene. | 24273214 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic inactivation of the BRCA1 interactor SRBC and resistance to oxaliplatin in colorectal cancer. | 24273214 |
| Primary Neoplasm, Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | SRBC epigenetic inactivation occurred in primary tumors from a discovery cohort of colorectal cancer patients (29.8%; n = 39 of 131), where it predicted shorter PFS (hazard ratio [HR] = 1.83; 95% confidence interval [CI] = 1.15 to 2.92; log-rank P = .01), particularly in oxaliplatin-treated case subjects for which metastasis surgery was not indicated (HR = 1.96; 95% CI = 1.13 to 3.40; log-rank P = .01). | 24273214 |
| Hollings Cancer Center | Epigenetic Alterations | MiRNAs showed high accuracy in identifying HCC, and could be a useful screening tool for diagnosing HCC patients. | 24273935 |
| Primary malignant neoplasm | Epigenetic Alterations | The role of E-cadherin down-regulation in oral cancer: CDH1 gene expression and epigenetic blockage. | 24274398 |
| Glioma | Epigenetic Alterations | Combined aberrant expression of microRNA-214 and UBC9 is an independent unfavorable prognostic factor for patients with gliomas. | 24277415 |
| Neoplasms | Epigenetic Alterations | MicroRNA-214 (miR-214) plays an important role in tumor cell proliferation, migration and invasion, as well as tumor angiogenesis. | 24277415 |
| Colorectal Carcinoma | Epigenetic Alterations | MicroRNA-338-3p inhibits colorectal carcinoma cell invasion and migration by targeting smoothened. | 24277750 |
| Colorectal Carcinoma | Epigenetic Alterations | The microRNA-338-3p expression pattern of colorectal carcinoma tissues and cell lines was detected by real-time reverse transcriptase polymerase chain reaction. | 24277750 |
| Colorectal Carcinoma | Epigenetic Alterations | Furthermore, colorectal carcinoma cells were pretreated with or without anti-smoothened-small interfering ribonucleic acid prior to the addition of pre-microRNA-338-3p or anti-microRNA-338-3p. | 24277750 |
| Colorectal Carcinoma, Metastasis, Neoplasms | Epigenetic Alterations | The expression of microRNA-338-3p was significantly down-regulated in colorectal carcinoma tissues in comparison with those in the adjacent non-tumorous tissues, and the value was negatively related to advanced tumor, node, metastasis stage and local invasion. | 24277750 |
| Colorectal Carcinoma | Epigenetic Alterations | The expression of microRNA-338-3p in colorectal carcinoma cells transfected with pre-microRNA-338-3p p was significantly increased. | 24277750 |
| Colorectal Carcinoma | Epigenetic Alterations | Furthermore, over-expression of microRNA-338-3p inhibited the expression of smoothened protein in colorectal carcinoma cells, which showed obviously suppressed invasion and migration ability. | 24277750 |
| Colorectal Carcinoma | Epigenetic Alterations | The expression of microRNA-338-3p in colorectal carcinoma cells transfected with anti-microRNA-338-3p was significantly decreased. | 24277750 |
| Colorectal Carcinoma | Epigenetic Alterations | Moreover, the down-regulated expression of microRNA-338-3p caused the up-regulated expression of smoothened protein in colorectal carcinoma cells, which showed significantly enhanced invasion and migration ability. | 24277750 |
| Colorectal Carcinoma | Epigenetic Alterations | However, anti-smoothened-small interfering ribonucleic acid largely, but not completely, reversed the effects induced by blockage of microRNA-338-3p, suggesting that the regulative effect of microRNA-338-3p on colorectal carcinoma cell invasion and migration was indeed mediated by smoothened. | 24277750 |
| Colorectal Carcinoma | Epigenetic Alterations | MicroRNA-338-3p could inhibit colorectal carcinoma cell invasion and migration by inhibiting smoothened expression. | 24277750 |
| Tuberculosis, Pulmonary | Epigenetic Alterations | miRNA signatures in sera of patients with active pulmonary tuberculosis. | 24278252 |
| Primary malignant neoplasm | Epigenetic Alterations | One-carbon metabolism is the basement of nucleotide synthesis and the methylation of DNA linked to cancer risk. | 24278388 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Loss of microRNA-200a expression correlates with tumor progression in breast cancer. | 24280074 |
| Malignant Neoplasms | Epigenetic Alterations | The miRNA-200 family has been shown to play a crucial role in the epithelial to mesenchymal transition in human cancers. | 24280074 |
| Malignant neoplasm of breast, Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | MiRNA-200a expression was demonstrated in 95.2% of normal breast tissue samples and 80.4% of DCIS, whereas 178 (58.0%) of 307 breast cancers and 83.3% of metastatic lymph node samples lacked miRNA-200a expression (P < 0.001). | 24280074 |
| Neoplasms | Epigenetic Alterations | Moreover, loss of MiRNA-200a expression correlated with high histologic grade (P = 0.017) and perinodal tumor extension (P = 0.026). | 24280074 |
| Malignant neoplasm of breast, Neoplasms | Epigenetic Alterations | In conclusion, loss of miRNA-200a is frequently observed in breast cancers, especially tumors with high grade histology. | 24280074 |
| Breast Carcinoma | Epigenetic Alterations | These findings suggest that miRNA-200a may play an important role in breast cancer initiation and progression. | 24280074 |
| Carcinoma of lung | Epigenetic Alterations | Measuring miRNA expression levels in sputum could provide a potential approach for the diagnosis of lung cancer. | 24281335 |
| Carcinoma of lung | Epigenetic Alterations | As digital PCR becomes more established, it would be a robust tool for quantitative assessment of miRNA copy number in sputum for lung cancer diagnosis. | 24281335 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in the initiation and progression of lung cancer. | 24281335 |
| Carcinoma of lung | Epigenetic Alterations | Digital PCR quantification of miRNAs in sputum for diagnosis of lung cancer. | 24281335 |
| Carcinoma of lung | Epigenetic Alterations | We then used digital PCR to quantify copy number of two lung cancer-associated miRNAs (miR-31 and miR-210) in 35 lung cancer patients and 40 cancer-free controls. | 24281335 |
| Pathology, Cardiovascular Diseases | Epigenetic Alterations | miRNAs (microRNAs), the small non-coding RNA molecules that regulate gene expression, have been shown previously to be associated with a broad range of human pathologies, including cardiovascular diseases. | 24283299 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | microRNA profiling in patients with abdominal aortic aneurysms: the significance of miR-155. | 24283299 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Histone methylation and acetylation play important roles in the carcinogenesis and progression of cancer. | 24283856 |
| Prostate Cancer Pathway | Epigenetic Alterations | The tumor-suppressive microRNA-143/145 cluster inhibits cell migration and invasion by targeting GOLM1 in prostate cancer. | 24284362 |
| Primary malignant neoplasm | Epigenetic Alterations | Restoration of miR-143 or miR-145 in PCa cell lines (PC3 and DU145) revealed that these miRNAs significantly inhibited cancer cell migration and invasion. | 24284362 |
| Hypertensive disease | Epigenetic Alterations | Differential expression of vascular smooth muscle-modulating microRNAs in human peripheral blood mononuclear cells: novel targets in essential hypertension. | 24284386 |
| Hypertensive disease | Epigenetic Alterations | Our data provide important evidence that VSMC-modulating microRNAs are closely related to essential hypertension in humans and they may represent potential therapeutic targets in essential hypertension. | 24284386 |
| Glioma | Epigenetic Alterations | Gliomas with H3F3A K27M from pediatric or young adult patients had similar, characteristic DNA methylation profiles. | 24285547 |
| Glioblastoma, Glioma | Epigenetic Alterations | In contrast, thalamic gliomas with wild-type H3F3A had DNA methylation profiles similar to those of hemispheric glioblastomas. | 24285547 |
| Primary malignant neoplasm | Epigenetic Alterations | Small non-coding microRNAs (miRNAs) are key components of cancer development and are considered as potential biomarkers for cancer diagnosis and for monitoring treatment. | 24286416 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Epigenetic marks are extensively altered in cancer but may also change in normal tissues with age, which is the primary risk factor for most cancers. | 24287154 |
| Malignant neoplasm of breast, Breast Carcinoma, Neoplasms | Epigenetic Alterations | In conclusion, although most variation in methylation status is present between individual breast cancers, clonal epigenetic heterogeneity is seen within most primary breast carcinomas, indicating that methylation results from a single random sample may not be representative of the whole tumor. | 24287456 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs are small non-coding RNAs, and it is suggested that knowledge of microRNA expression profiles in cancer may have substantial value for diagnostics. | 24287458 |
| Rhabdoid Tumor, Sarcoma, Epithelioid | Epigenetic Alterations | Differential microRNA expression profiles between malignant rhabdoid tumor and epithelioid sarcoma: miR193a-5p is suggested to downregulate SMARCB1 mRNA expression. | 24287458 |
| Rhabdoid Tumor | Epigenetic Alterations | We first analyzed microRNA expression profiles in 13 frozen materials (five malignant rhabdoid tumors, two proximal type epithelioid sarcomas, and six conventional type epithelioid sarcomas) and subsequently examined the specific microRNA expressions in 29 paraffin-embedded materials (8 malignant rhabdoid tumors, 13 proximal type epithelioid sarcomas, and 8 conventional type epithelioid sarcomas) and 13 previously described frozen materials by quantitative RT-PCR. | 24287458 |
| Rhabdoid Tumor, Sarcoma, Epithelioid | Epigenetic Alterations | According to the unsupervised hierarchical clustering of microRNA, proximal type epithelioid sarcoma and conventional type epithelioid sarcoma were classified into the same category, whereas malignant rhabdoid tumor was a distinct category from both types of epithelioid sarcoma. | 24287458 |
| Rhabdoid Tumor, Neoplasms, Sarcoma, Epithelioid | Epigenetic Alterations | These results suggest that epithelioid sarcoma, especially proximal type epithelioid sarcoma, and malignant rhabdoid tumor are distinct tumors with respect to the microRNA expression profiles and that miR193a-5p may have an important role in the inhibition of SMARCB1 mRNA expression. | 24287458 |
| Rhabdoid Tumor, Sarcoma, Epithelioid | Epigenetic Alterations | In addition, when malignant rhabdoid tumor with SMARCB1 gene alterations and proximal type and conventional type epithelioid sarcoma with no SMARCB1 gene alterations were compared, 56 microRNAs were isolated as being significantly different (ANOVA, P<0.05). | 24287458 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA) polymorphisms contribute to cancer susceptibility and prognosis. | 24288122 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy. | 24288122 |
| Clinical Coordinator, Colorectal Cancer Pathway, Pancreatic carcinoma | Epigenetic Alterations | Profiling of DNA methylation status of specific genes is a way to screen for colorectal cancer (CRC) and pancreatic cancer (PC) in blood. | 24288256 |
| Fibromyxosarcoma | Epigenetic Alterations | The new myxofibrosarcoma cell line MUG-Myx1 was established to enrich the bank of publicly available cell lines, with respect to providing comprehensive genetic and epigenetic characterization. | 24289252 |
| Clinical Coordinator, Malignant Neoplasms | Epigenetic Alterations | We showed the potential of NPY, PENK, and WIF1 as combined epigenetic markers for CRC diagnosis, both in tissue and serum and tested their use as serum biomarkers in other cancers. | 24289328 |
| MIR206 wt Allele, melanoma | Epigenetic Alterations | MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D. Expression profiling of microRNAs in melanoma lesional skin biopsies compared with normal donor skin biopsies, as well as melanoma cell lines compared with normal melanocytes, revealed that hsa-miR-206 was down-regulated in melanoma (-75.4-fold, P = 1.7 x 10(-4)). | 24289491 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-25 (miR-25) has recently been found to be involved in many critical processes in human malignancies. | 24293092 |
| Cerebrovascular Disorders | Epigenetic Alterations | The level of global DNA methylation may be related to the cerebrovascular disease. | 24295503 |
| Laryngeal Squamous Cell Carcinoma | Epigenetic Alterations | MicroRNA-205 suppresses proliferation and promotes apoptosis in laryngeal squamous cell carcinoma. | 24297308 |
| Neoplasms | Epigenetic Alterations | MicroRNAs were reported to be involved in the modulation of tumor development. | 24297308 |
| Malignant neoplasm of mouth | Epigenetic Alterations | Genetic variations at microRNA and processing genes and risk of oral cancer. | 24297336 |
| Primary malignant neoplasm | Epigenetic Alterations | Genetic variations at microRNA and microRNA processing genes are known to confer risk of cancer in different populations. | 24297336 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. | 24298892 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Our results indicate that aberrant DNA methylation is (1) a genome-wide phenomenon in small airways of patients with COPD, and (2) associated with altered expression of genes and pathways important to COPD, such as the NF-E2-related factor 2 oxidative response pathway. | 24298892 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | DNA methylation is likely an important mechanism contributing to modulation of genes important to COPD pathology. | 24298892 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Because these methylation events may underlie disease-specific gene expression changes, their characterization is a critical first step toward the development of epigenetic markers and an opportunity for developing novel epigenetic therapeutic interventions for COPD. | 24298892 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | At DNA, mRNA and miRNA levels we could identify molecular markers that discriminated significantly between the various histopathological entities of NSCLC. | 24299561 |
| Primary malignant neoplasm | Epigenetic Alterations | Alternatively, noncoding RNAs (ncRNAs) are emerging as key molecules in human cancer, with the potential to serve as novel markers of disease, e.g. | 24300377 |
| Papillary thyroid carcinoma | Epigenetic Alterations | MicroRNA-222 and microRNA-146b are tissue and circulating biomarkers of recurrent papillary thyroid cancer. | 24301304 |
| Neoplasms, F9 gene | Epigenetic Alterations | Patients with recurrent PTC (Rc-PTC) and those without recurrence (NR-PTC) were retrospectively recruited for a comparison of their tumor miRNA profiles. | 24301304 |
| Fibrosis Assessment | Epigenetic Alterations | Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype. | 24301681 |
| Fibrosis Assessment | Epigenetic Alterations | Epigenetic changes may play an important role in modulating hypoxia-induced fibrosis within the heart. | 24301681 |
| Hypoxia | Epigenetic Alterations | Epigenetic modifications and changes in the epigenetic machinery identified in cardiac fibroblasts during prolonged hypoxia may contribute to the pro-fibrotic nature of the ischemic milieu. | 24301681 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Recurrent deletions and somatic mutations in TET2, a gene involved in epigenetic regulation, have been reported in about 20% of adult patients with myelodysplastic syndrome. | 24301955 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy. | 24304648 |
| Clinical Coordinator | Epigenetic Alterations | We identified a group of miRNA predictors in response to chemosensitivity for CRC patients. | 24304648 |
| Carcinoma of lung | Epigenetic Alterations | The sputum miRNA biomarkers might be useful in improving CT for diagnosis of lung cancer, but further independent validation on an external and prospective cohort of patients is required. | 24305007 |
| Carcinoma of lung | Epigenetic Alterations | Analysis of MicroRNAs in sputum to improve computed tomography for lung cancer diagnosis. | 24305007 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | We previously identified 12 microRNAs (miRNAs) whose expressions in tumor tissues were associated with lung cancer. | 24305007 |
| Carcinoma of lung | Epigenetic Alterations | In a training set consisting of 66 lung cancer patients and 68 cancer-free smokers, 10 of the 12 miRNAs were differentially expressed between the cases and controls (p <= 0.01). | 24305007 |
| Carcinoma of lung | Epigenetic Alterations | From the miRNAs, a logistic regression model was built on the basis of miR-31 and miR-210, both of which had the best prediction for lung cancer, producing an area under receiver operating characteristic curve of 0.83. | 24305007 |
| Carcinoma of lung | Epigenetic Alterations | Combined use of the two miRNAs yielded 65.2% sensitivity and 89.7% specificity, CT had 93.9% sensitivity and 83.8% specificity for lung cancer diagnosis. | 24305007 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | By miRNA expression profiling of microdissected human tumor biopsy specimens we identified miR-328 as one of the main miRNAs upregulated in invading glioma cells in vivo and further investigated its role in glioma pathogenesis. | 24305703 |
| Glioma | Epigenetic Alterations | Methods We employed miRNA mimics and inhibitors to functionally characterize miR-328, 3 untranslated region luciferase assays, and T-cell factor/lymphoid enhancer factor reporter assays to pinpoint miR-328 targets and signaling pathways, and analyzed miR-328 expression in a large panel of gliomas. | 24305703 |
| Glioma | Epigenetic Alterations | High-throughput microRNA profiling of pediatric high-grade gliomas. | 24305714 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) have been identified as key molecules in gene expression regulation, both in development and in cancer. | 24305714 |
| Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNA (miRNA) expression is deregulated in many tumors including chronic lymphocytic leukemia (CLL). | 24306027 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia. | 24306027 |
| Neoplasms | Epigenetic Alterations | The candidate prognostic biomarkers, SMAD4 protein loss (P=.01) in tumor cells and microRNA-21 expression in the stroma (P=.05), also correlated with OS. | 24306217 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | We investigated the relationship between the expression of frequently deregulated microRNAs (miRNAs) as well as their target genes (ZEB1/ZEB2) and bladder cancer histopathological grade in an attempt to find a miRNA that might allow more reliable grading of PUTs. | 24306957 |
| Papillary neoplasm | Epigenetic Alterations | Expression of miRNAs and ZEB1 and ZEB2 correlates with histopathological grade in papillary urothelial tumors of the urinary bladder. | 24306957 |
| Bladder Neoplasm | Epigenetic Alterations | We measured the expression levels of four miRNAs (miR-145, miR-205, miR-125b, and miR-200c) in 120 formalin-fixed, paraffin-embedded bladder tumor tissue samples using real-time PCR assays. | 24306957 |
| Cataract | Epigenetic Alterations | Epigenetic regulation of aA-crystallin in high myopia-induced dark nuclear cataract. | 24312600 |
| CRYAA gene | Epigenetic Alterations | To assess the etiology of early-onset dark nucleus in high-myopic patients and its relationship with the epigenetic regulation of aA-crystallin (CRYAA). | 24312600 |
| Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | Significance of serum and hepatic microRNA-122 levels in patients with non-alcoholic fatty liver disease. | 24313922 |
| Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | We extracted the total RNA, along with preserved miRNAs, from liver biopsy samples of 67 patients with NAFLD. | 24313922 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Evaluation of long noncoding RNA MALAT1 as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer. | 24313945 |
| Adenocarcinoma of lung (disorder), Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The long noncoding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) is described as a potential biomarker for NSCLC (non-small cell lung cancer). | 24313945 |
| ibudilast | Epigenetic Alterations | Additionally, DNA methylation has been reported to be correlated with the development of IBD. | 24317008 |
| ibudilast, Inflammatory Bowel Diseases | Epigenetic Alterations | Mounting evidence suggests that inflammatory bowel disease (IBD) is caused by genetic predisposition of various genes as well as an abnormal interaction with environmental factors, resulting in epigenetic alterations. | 24317008 |
| Stomach Carcinoma | Epigenetic Alterations | Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. | 24317477 |
| Stomach Carcinoma | Epigenetic Alterations | We examined the microRNA (miRNA) expression of 35 patients who underwent S-1 adjuvant chemotherapy after curative surgery (R0) for pathological stage II or III gastric cancer. | 24317477 |
| Neoplasms | Epigenetic Alterations | If tumors showed high expression of 4 miRNAs (miR-92b, 422a, 4732-5p and 4758-3p) their positive predictive value of relapse was 93.8% and negative predictive value was 92.3%. | 24317477 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | DNA methylation analysis was performed to determine the regulatory mechanism of DENND2D expression in ESCC. | 24317529 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | These results suggest that the miRNA-196a2 functional polymorphism rs11614913 might be an effective genetic marker for ESCC risk assessment in individuals younger than 60 years of age from a region of high ESCC incidence in northern China. | 24320161 |
| Malignant Neoplasms, Liver carcinoma | Epigenetic Alterations | The overexpression of microRNA-221 (miR-221) is reported in several human cancers including hepatocellular carcinoma, and its targeting by tailored treatments has been proposed. | 24324033 |
| palladium, Parkinson Disease | Epigenetic Alterations | Recent studies suggest that epigenetic factors may play an important role in the pathogenesis of Parkinsons disease (PD). | 24325350 |
| Primary malignant neoplasm | Epigenetic Alterations | The deregulation of microRNA (miRNA) is associated with multiple processes involved in cancer progression. | 24325353 |
| Malignant Neoplasms | Epigenetic Alterations | RNase III endonucleases, Dicer and Drosha, are key enzymes for miRNA biogenesis, and it has been reported that altered expressions of these molecules affect the clinical outcomes of patients with various cancers. | 24325353 |
| Obesity, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity. | 24325907 |
| Obesity, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Our results provide evidence that a different composition of gut microbiota in obesity and type 2 diabetes affect the epigenetic regulation of genes. | 24325907 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-21 expression is associated with overall survival in patients with glioma. | 24326156 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-21 has been proved to be associated with glioma proliferation and invasion; thus, we sought to clarify the clinical value of miR-21 expression in glioma tissues with WHO grade I to IV. | 24326156 |
| palladium | Epigenetic Alterations | Hypomethylation of SNCA intron-1 was detected in PBMCs of PD patients, and DNA methylation levels were associated with Rep1 polymorphism. | 24326201 |
| Cachexia, Lipolysis | Epigenetic Alterations | MicroRNA profiling links miR-378 to enhanced adipocyte lipolysis in human cancer cachexia. | 24326420 |
| Stomach Carcinoma | Epigenetic Alterations | The development of gastric cancer (GC) is a complex multistep process, including numerous genetic and epigenetic changes. | 24327257 |
| ovarian neoplasm | Epigenetic Alterations | Opioid binding protein/cell adhesion molecule-like gene (OPCML) has a tumor-suppressor function in ovarian cancer, and epigenetic inactivation of OPCML induces oncogenic transformation of human ovarian surface epithelial cells. | 24327526 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Activating mutations of genes involved in the BCR and NF-kB pathways (CD79A, CD79B, MYD88, and CARD11) or in epigenetic regulation (EZH2) have been recently reported, preferentially in one of the two DLBCL subtypes. | 24327543 |
| Carcinogenesis | Epigenetic Alterations | Histotype-specific miRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. | 24327568 |
| ACAA1 gene | Epigenetic Alterations | All miRNAs were remarkably up-regulated in ATC samples compared with PTL samples (P < .01). | 24327568 |
| Malignant neoplasm of liver | Epigenetic Alterations | Epigenetic silencing of glutaminase 2 in human liver and colon cancers. | 24330717 |
| Malignant neoplasm of liver, Primary malignant neoplasm | Epigenetic Alterations | Importantly, the lower level of Gls2 in cancer cells was closely correlated to its promoter hypermethylation; and chemical demethylation treatment with 5-aza-2-deoxycytidine (Aza) increased Gls2 mRNA level in both liver and colon cancer cells, indicating that direct epigenetic silencing suppressed Gls2 expression by methylation. | 24330717 |
| Carcinogenesis, Malignant neoplasm of liver, Neoplasms | Epigenetic Alterations | We provide evidence showing that epigenetic silencing of Gls2 via promoter hypermethylation is common in human liver and colon cancers and Gls2 appears to be a functional tumor suppressor involved in the liver and colon tumorigenesis. | 24330717 |
| Colorectal Cancer Pathway | Epigenetic Alterations | miR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression. | 24330809 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | MicroRNA-133b (miR-133b), which is a muscle-specific microRNA, has been reported to be downregulated in human colorectal carcinoma (CRC) when compared to adjacent non-tumor tissue. | 24330809 |
| Multiple Chronic Conditions, Cardiovascular Diseases, Primary malignant neoplasm | Epigenetic Alterations | Disturbances of DNA methylation have been associated with multiple diseases, including cardiovascular disease, cancer and, as some have suggested, glucometabolic disturbances. | 24331772 |
| Metabolic Syndrome X | Epigenetic Alterations | This association was mainly attributable to linear associations of two metabolic syndrome components with DNA methylation: fasting plasma glucose (b = -0.02; p = 0.004) and high-density lipoprotein cholesterol (b = 0.07; p = 0.004). | 24331772 |
| AIDS-Related Hodgkin Lymphoma | Epigenetic Alterations | DNA methylation profiling can classify HIV-associated lymphomas. | 24335480 |
| AIDS-Related Hodgkin Lymphoma | Epigenetic Alterations | DNA methylation profiling indicated that 2541 target sites differed significantly in HIV-associated lymphoma, which may partly explain the poor prognosis. | 24335480 |
| Sarcoma - category (morphologic abnormality) | Epigenetic Alterations | Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling. | 24336067 |
| Adrenocortical carcinoma, Adenoma, miR-181b, human | Epigenetic Alterations | In contrast, of the selected eight miRNAs reported in the literature as differentially expressed in ACT tissues, five (hsa-miR-100, hsa-miR-181b, hsa-miR-184, hsa-miR-210 and hsa-miR-483-5p) showed a statistically significant overexpression in adrenocortical cancer vs adenoma when normalized on hsa-miR-16 as a reference gene. | 24336071 |
| Liver carcinoma | Epigenetic Alterations | miRNA-302b suppresses human hepatocellular carcinoma by targeting AKT2. | 24337067 |
| Malignant Neoplasms, Liver carcinoma | Epigenetic Alterations | miRNAs (miR) play a critical role in human cancers, including hepatocellular carcinoma. | 24337067 |
| Neoplasms, Prostate carcinoma | Epigenetic Alterations | Comparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing. | 24337069 |
| Non-Malignant, Prostate carcinoma | Epigenetic Alterations | Previous deep sequencing identified the miRNA profile of prostate carcinoma versus nonmalignant prostate tissue. | 24337069 |
| Neoplasms, Prostate carcinoma | Epigenetic Alterations | Here, we generated miRNA expression profiles of prostate carcinoma by deep sequencing, with increasing tumor stage relative to corresponding nonmalignant and healthy prostate tissue, and detected clearly changed miRNA expression patterns. | 24337069 |
| Neoplasms | Epigenetic Alterations | The regulation for other selected miRNAs could, however, not be confirmed by qRT-PCR in individual tumor stages. | 24337069 |
| Prostate Cancer Pathway | Epigenetic Alterations | These genomic data reveal relevant miRNAs in prostate cancer that may have biomarker and therapeutic potential. | 24337069 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Methylation of CpG islands in the promoter region of genes acts as a significant mechanism of epigenetic gene silencing in head and neck cancer. | 24337411 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Upregulation of the long non-coding RNA PlncRNA-1 promotes esophageal squamous carcinoma cell proliferation and correlates with advanced clinical stage. | 24337686 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent studies revealed that long noncoding RNAs (lncRNAs) play critical regulatory roles in cancer biology. | 24337686 |
| Neoplasms | Epigenetic Alterations | We report here the first instance of epigenetic downregulation in NPC tumor biopsies of a key enzyme, CYB5R2, which is responsible for the detoxification of environmental carcinogens. | 24338690 |
| Hepatitis B | Epigenetic Alterations | Association of a microRNA-323b polymorphism with the persistence of hepatitis B virus infection by the enhancement of viral replication. | 24341744 |
| Prostate Cancer Pathway | Epigenetic Alterations | Epigenetic regulation of MDR1 gene through post-translational histone modifications in prostate cancer. | 24344919 |
| CHOANAL ATRESIA, POSTERIOR, Prostate carcinoma | Epigenetic Alterations | MDR1 promoter methylation is frequent in prostate carcinoma (PCa), suggesting an epigenetic regulation but no functional correlation has been established. | 24344919 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | We aimed to elucidate the epigenetic mechanisms involved in MDR1 deregulation in PCa. | 24344919 |
| Acute chest pain | Epigenetic Alterations | Diagnostic and prognostic value of circulating microRNAs in patients with acute chest pain. | 24345063 |
| Primary Vitreoretinal Lymphoma, Uveitis | Epigenetic Alterations | Primary vitreoretinal B-cell lymphoma and uveitis might be characterized by distinct microRNA signatures. | 24345320 |
| Childhood Medulloblastoma | Epigenetic Alterations | Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma. | 24346283 |
| Childhood Medulloblastoma | Epigenetic Alterations | Thus, re-expression of microRNA-9 may constitute a novel epigenetic regulation strategy against medulloblastoma. | 24346283 |
| Malignant Neoplasms, Childhood Medulloblastoma | Epigenetic Alterations | microRNA-9 is a key regulator of neuronal development aberrantly expressed in brain malignancies, including medulloblastoma. | 24346283 |
| Childhood Medulloblastoma | Epigenetic Alterations | The association of microRNA-9 expression with medulloblastoma patients clinical outcome was assessed, and the impact of microRNA-9 restoration was functionally validated in medulloblastoma cells. | 24346283 |
| Childhood Medulloblastoma | Epigenetic Alterations | HES1 was identified as a direct target of microRNA-9 in medulloblastoma, and restoration of microRNA-9 was shown to trigger cell cycle arrest, to inhibit clonal growth and to promote medulloblastoma cell differentiation. | 24346283 |
| Childhood Medulloblastoma, Neoplasms | Epigenetic Alterations | microRNA-9 is a methylation-silenced tumour suppressor that could be a potential candidate predictive marker for poor prognosis of medulloblastoma. | 24346283 |
| Neoplasms | Epigenetic Alterations | Loss of microRNA-9 may confer a proliferative advantage to tumour cells, and it could possibly contribute to disease pathogenesis. | 24346283 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | These data support the notion that epigenetic changes have clinical impact in CLL and may contribute to the identification of novel candidate disease-associated genes potentially useful to predict the clinical outcome of early stage CLL patients. | 24347044 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | Identification and validation of reference genes for qPCR detection of serum microRNAs in colorectal adenocarcinoma patients. | 24349425 |
| Adenoma of large intestine, Adenocarcinoma of large intestine | Epigenetic Alterations | We firstly profiled pooled serum of colorectal adenocarcinoma, colorectal adenoma and healthy controls and selected a list of 13 miRNAs as candidate reference genes. | 24349425 |
| Prostate Cancer Pathway | Epigenetic Alterations | Association of microRNA-126 expression with clinicopathological features and the risk of biochemical recurrence in prostate cancer patients undergoing radical prostatectomy. | 24350576 |
| Primary malignant neoplasm | Epigenetic Alterations | Numerous studies have suggested that microRNA-126 (miR-126) is involved in development of various cancer types as well as in malignant proliferation and invasion. | 24350576 |
| Neoplasms | Epigenetic Alterations | Epithelial tumors are thought to accumulate a series of genetic and epigenetic changes as they progress through well-defined clinical and histopathological changes. | 24351440 |
| Cell of Claudius | Epigenetic Alterations | MicroRNA expression signatures of stage, grade, and progression in clear cell RCC. | 24351440 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in the regulation of mRNA expression from many human genes and miRNA expression is dysregulated in cancer. | 24351440 |
| Malignant Neoplasms | Epigenetic Alterations | Pathways predicted as targets of the most significantly dysregulated miRNAs included signaling, epithelial cancers, metabolism, and epithelial to mesenchymal transition. | 24351440 |
| Diabetes Mellitus | Epigenetic Alterations | While diabetes mellitus affects plasma miRNAs, no data exist on platelet miRNA profiles in this disease. | 24352417 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Controlled type II diabetes mellitus has no major influence on platelet micro-RNA expression. | 24352417 |
| Diabetes Mellitus | Epigenetic Alterations | Functional annotation of predicted targets for these miRNAs pointed towards an influence of diabetes mellitus on mRNA processing. | 24352417 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA profiles of 90 gastric cancer cases identified two microRNA subtypes significantly associated with survival. | 24352645 |
| Stomach Carcinoma | Epigenetic Alterations | Integrated analysis identified a key microRNA regulatory network likely driving the gastric cancer mesenchymal subtype. | 24352645 |
| Stomach Carcinoma, Mesenchymal | Epigenetic Alterations | We have uncovered a key microRNA regulatory network that defines the mesenchymal gastric cancer subtype significantly associated with poor overall survival in gastric cancer. | 24352645 |
| Stomach Carcinoma | Epigenetic Alterations | RNA and protein expression were analyzed by RT-PCR and tissue microarray, respectively, in a cohort of 385 gastric cancer cases (including the 90 cases for profiling) to validate the key microRNAs and targets in the network. | 24352645 |
| Osteosarcoma | Epigenetic Alterations | Clinical significance of microRNA-183/Ezrin axis in judging the prognosis of patients with osteosarcoma. | 24352761 |
| Osteosarcoma, Neoplasms | Epigenetic Alterations | MicroRNA-183 (miR-183) has been demonstrated to be a tumor suppressor miRNA in inhibition of migration and invasion of osteosarcoma by targeting an oncogene Ezrin. | 24352761 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia. | 24356097 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | These results reveal that although evolution of DNA methylation occurs in high-risk, clinically progressive cases, positive selection of novel methylation patterns entails coevolution of genetic alteration(s) in CLL. | 24356097 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Although clonal selection by genetic driver aberrations in cancer is well documented, the ability of epigenetic alterations to promote tumor evolution is undefined. | 24356097 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer. | 24357161 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | IGFBP7 is associated with poor prognosis in oesophageal adenocarcinoma and is regulated by promoter DNA methylation. | 24357797 |
| Primary Cutaneous Follicle Center Lymphoma | Epigenetic Alterations | In conclusion, PCFCL and PCLBCL-LT differ in their microRNA profiles. | 24358187 |
| Diffuse Large B-Cell Lymphoma, Lymphoma | Epigenetic Alterations | Aberrant expression of microRNAs is widely accepted to be pathogenetically involved in nodal diffuse large B-cell lymphomas (DLBCLs). | 24358187 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | MicroRNA-17, microRNA-18a, and microRNA-19a are prognostic indicators in esophageal squamous cell carcinoma. | 24360091 |
| Malignant Neoplasms | Epigenetic Alterations | The members of the microRNA (miR)-17-92 cluster have been reported to be highly expressed in several cancers. | 24360091 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Clinical performance and utility of a DNA methylation urine test for bladder cancer. | 24360662 |
| Lymphoma, Non-Hodgkin, Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma. | 24362313 |
| Primary malignant neoplasm | Epigenetic Alterations | Genes with altered DNA methylation can be used as biomarkers for cancer detection and assessment of prognosis. | 24362313 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Efficacy and feasibility of the epithelial cell adhesion molecule (EpCAM) immunomagnetic cell sorter for studies of DNA methylation in colorectal cancer. | 24362576 |
| ovarian neoplasm | Epigenetic Alterations | Twenty-two miRNAs were differentially expressed between healthy controls and the ovarian cancer group (P<0.05), while a six miRNA profile subset distinguished presurgical plasma from benign and ovarian cancer patients. | 24366298 |
| ovarian neoplasm | Epigenetic Alterations | There were also significant differences in miRNA profiles in presurgical plasma from women diagnosed with ovarian cancer who had short overall survival when compared to women with long overall survival (P<0.05). | 24366298 |
| Carcinoma, Ovarian Epithelial, ovarian neoplasm | Epigenetic Alterations | Our preliminary data support the utility of circulating plasma miRNAs to distinguish women with ovarian cancer from those with a benign mass and identify women likely to benefit from currently available treatment for serous epithelial ovarian cancer from those who may not. | 24366298 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRs) are small non-coding RNAs that play important roles in cancer development where they can act as oncogenes or as tumor-suppressors. | 24370784 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Dysregulation of microRNA-34a expression in colorectal cancer inhibits the phosphorylation of FAK via VEGF. | 24370784 |
| Uveal melanoma | Epigenetic Alterations | Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease. | 24370793 |
| Cardiac Arrhythmia, Ischemia | Epigenetic Alterations | MicroRNA (miR) is emerging as an important regulator of mitochondrial function, arrhythmia, and protection from ischemia and reperfusion. | 24371264 |
| Primary malignant neoplasm | Epigenetic Alterations | Both genetic and epigenetic changes can contribute to cancer development and progression. | 24371281 |
| Malignant Neoplasms | Epigenetic Alterations | Given the vast genetic heterogeneity of human cancers and difficulty to monitor cancer-initiating events in vivo, the precise relationship between acquisition of genetic mutations and the temporal progression of epigenetic alterations in transformed cells is largely unclear. | 24371281 |
| AMD1 wt Allele | Epigenetic Alterations | Aberrant DNA methylation within the promoter of IL17RC in peripheral blood mononuclear cells has recently been reported in AMD. | 24373284 |
| Impaired cognition | Epigenetic Alterations | Overall, our results indicated that both Trisomy 21 and cognitive impairment were associated with distinct patterns of DNA methylation. | 24373378 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Changes in circulating microRNAs after radiochemotherapy in head and neck cancer patients. | 24373621 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNAs (miRNAs) are easily accessible and have already proven to be useful as prognostic markers in cancer patients. | 24373621 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia--implications on constitutive activation of NFkB pathway. | 24373626 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | The miR-9 family microRNAs have been identified as a tumor suppressor miRNA in cancers. | 24373626 |
| Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | Of the miR-9 family, miR-9-3 is a tumor suppressor miRNA relatively frequently methylated, and hence silenced in CLL; whereas miR-9-1 methylation is rare in CLL. | 24373626 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | LINE1 and Alu repetitive element DNA methylation in tumors and white blood cells from epithelial ovarian cancer patients. | 24374023 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | We determined whether DNA methylation of repetitive elements (RE) is altered in epithelial ovarian cancer (EOC) patient tumors and white blood cells (WBC), compared to normal tissue controls. | 24374023 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant DNA methylation on CpG islands is one of the most consistent epigenetic changes in human cancers, and the process of methylation is catalyzed by the DNA methyltransferases DNMT1, DNMT3a, and DNMT3b. | 24375250 |
| Malignant Neoplasms, Carcinogenesis | Epigenetic Alterations | Recent reports demonstrate that deregulation of miR-124a, one of the frequently methylated microRNAs in human cancers, is related to carcinogenesis. | 24375250 |
| Colorectal Cancer Pathway | Epigenetic Alterations | A genetic variant in microRNA target site of TGF-b signaling pathway increases the risk of colorectal cancer in a Chinese population. | 24375256 |
| Primary malignant neoplasm | Epigenetic Alterations | Evidence shows that single-nucleotide polymorphisms in microRNA (miRNA) target sites can create, destroy, or modify the miRNA/mRNA binding, therefore modulating gene expression and affecting cancer susceptibility. | 24375256 |
| Clinical Coordinator | Epigenetic Alterations | To test the hypothesis that genetic variants in miRNA target sites in genes of the TGF-b signaling pathway may also be associated with CRC risk, we first systematically scanned the single-nucleotide polymorphisms (SNPs) in genes of TGF-b signaling pathway which potentially affect the miRNA/mRNA bindings. | 24375256 |
| Clinical Coordinator, Carcinogenesis | Epigenetic Alterations | Our study suggested that SNPs in miRNA target sites could contribute to the likelihood of CRC susceptibility and emphasized the important role of polymorphisms at miRNA-regulatory elements in carcinogenesis. | 24375256 |
| liposarcoma, Neoplasms | Epigenetic Alterations | MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors. | 24375455 |
| liposarcoma | Epigenetic Alterations | MiRNA signatures of liposarcoma subtypes were established and validated in an independent series of 58 liposarcomas and control tissues. | 24375455 |
| liposarcoma | Epigenetic Alterations | In conclusion, we show that miRNA expression profiling can be used to discriminate liposarcoma subtypes, which can possibly aid in objective diagnostic decision making. | 24375455 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have been associated with carcinogenesis in many tumors and may function as tumor suppressor or oncogene. | 24375455 |
| liposarcoma | Epigenetic Alterations | Supervised hierarchical clustering of the most differentially expressed miRNAs (p < 0.0002) distinguished most liposarcoma subtypes and control tissues. | 24375455 |
| liposarcoma, Neoplasms | Epigenetic Alterations | In addition, our data indicate that miR-145 and miR-451 act as tumor suppressors in adipose tissue and show that re-expression of these miRNAs could be a promising therapeutic strategy for liposarcomas. | 24375455 |
| Parkinson Disease | Epigenetic Alterations | DNA methylation of the MAPT gene in Parkinsons disease cohorts and modulation by vitamin E in vitro. | 24375821 |
| palladium, Neurodegenerative Disorders, Parkinson Disease | Epigenetic Alterations | Parkinsons disease (PD) is a neurodegenerative disorder for which environmental factors influence disease risk and may act via an epigenetic mechanism. | 24375821 |
| Hollings Cancer Center | Epigenetic Alterations | The epigenetic changes observed in this study indicate that HCC tumors exhibit specific DNA methylation signatures with potential clinical applications in diagnosis and prognosis. | 24377595 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score. | 24378410 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | A seven-gene score encompassing epigenetic and genetic prognostic information identifies novel AML subsets that are meaningful for treatment guidance. | 24378410 |
| Primary malignant neoplasm | Epigenetic Alterations | There is increasing evidence that microRNAs (miRNAs) are involved in cancer development and progression. | 24379138 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Our results, which identified the plasma miR-221/222 at variable levels during RCC development, suggest that these miRNAs may have a potential as noninvasive biomarkers of RCC development. | 24379138 |
| Glioblastoma Multiforme | Epigenetic Alterations | Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme. | 24380367 |
| Glioma, Neoplasms | Epigenetic Alterations | Concomitant microRNA-31 downregulation and radixin upregulation predicts advanced tumor progression and unfavorable prognosis in patients with gliomas. | 24380686 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | To clarify the clinical significance of microRNA-31 (miR-31) and radixin (RDX) in human glioma. | 24380686 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-210 overexpression predicts poorer prognosis in glioma patients. | 24382515 |
| Hypoxia, Neoplasms | Epigenetic Alterations | MicroRNA-210 (miR-210) levels are elevated in many tumor types, are frequently associated with hypoxia induction, and are correlated with poor prognosis in many solid tumors. | 24382515 |
| Prostate Cancer Pathway | Epigenetic Alterations | MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1. | 24382668 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our previous microarray data showed that microRNA-224 (miR-224) was downregulated in human prostate cancer (PCa) tissues compared with adjacent benign tissues. | 24382668 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | DNA methylation profiling of well-differentiated thyroid cancer uncovers markers of recurrence free survival. | 24382797 |
| Thyroid Neoplasm | Epigenetic Alterations | Here, we investigated the role of aberrant DNA methylation in the development of well-differentiated thyroid tumors. | 24382797 |
| Primary Neoplasm, Thyroid Neoplasm | Epigenetic Alterations | We performed genome-wide DNA methylation profiling in the largest well-differentiated thyroid tumor series reported to date, comprising 83 primary tumors as well as 8 samples of adjacent normal tissue. | 24382797 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | This comprehensive study provides insights into the role of DNA methylation in well-differentiated thyroid cancer development and identifies novel markers associated with recurrence-free survival. | 24382797 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | Thyroid cancer is a heterogeneous disease with several subtypes characterized by cytological, histological and genetic alterations, but the involvement of epigenetics is not well understood. | 24382797 |
| Carcinoma, Follicular neoplasm, Neoplasms, Adenoma | Epigenetic Alterations | The epigenetic profiles were closely related to not only tumor histology but also the underlying driver mutation; we found that follicular tumors had higher levels of methylation, which seemed to accumulate in a progressive manner along the tumorigenic process from adenomas to carcinomas. | 24382797 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations such as DNA methylation are widespread cancer, contributing to tumorigenesis and acting as markers for prognostication. | 24383114 |
| Colorectal Cancer Pathway, Intestinal Cancer | Epigenetic Alterations | The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer. | 24384857 |
| Primary malignant neoplasm | Epigenetic Alterations | Additionally, a significant negative correlation was observed between methylation and DCLK1 expression in 74 cancer cell lines derived from 15 different tissues, and gene expression increased significantly after epigenetic drug treatment of initially methylated cancer cell lines. | 24384857 |
| Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, Neoplasms | Epigenetic Alterations | The purpose of this study is to identify new tumor suppressor miRNA and elucidate its physiological function and mechanism in renal cell carcinoma (RCC). | 24384875 |
| Malignant Neoplasms | Epigenetic Alterations | Abnormal expression of miRNAs is closely related to a variety of human cancers. | 24384875 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | A single microRNA signature classified CML from normal was detected. | 24385111 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | The results showed that three microRNAs (miR-150, miR-23a, and miR-130a) were identified to significantly decrease in expanded 38 CML patients compared with 90 normal controls. | 24385111 |
| Childhood Leukemia, Neoplasms | Epigenetic Alterations | All these results indicated that those three microRNAs could act as a tumor suppressor and their decreased expression might be one of the causes of leukemia. | 24385111 |
| Pleural Effusion, Malignant | Epigenetic Alterations | Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant and malignant pleural effusions. | 24386354 |
| Primary malignant neoplasm | Epigenetic Alterations | The combined analysis of cytology and DNA methylation resulted in an increase of 71% positively classified PEs from cancer patients as compared to cytological analysis alone. | 24386354 |
| Alzheimers Disease | Epigenetic Alterations | Global changes in DNA methylation and hydroxymethylation in Alzheimers disease human brain. | 24387984 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers altered in Alzheimers disease (AD) brain. | 24387984 |
| Thymic epithelial tumor, Neoplasms | Epigenetic Alterations | A key challenge in diagnosis and treatment of thymic epithelial tumors (TET) is in improving our understanding of the genetic and epigenetic changes of these relatively rare tumors. | 24388682 |
| Carcinoma of lung | Epigenetic Alterations | Methylation quantification using MS-qPCR and pyrosequencing of cytological lymph node samples obtained using echobronchoscopy is feasible if an appropriate DNA concentration is obtained, notably contributing to the identification of epigenetic biomarkers capable of improving decision-making for the benefit of potentially curable lung cancer patients. | 24388707 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1. | 24388988 |
| melanoma, Neoplasms | Epigenetic Alterations | We recently reported the loss of 5-hydroxymethylcytosine in melanoma compared with benign nevi and suggested that loss of this epigenetic marker is correlated with tumor virulence based on its association with a worse prognosis. | 24390216 |
| Malignant Neoplasms | Epigenetic Alterations | Changes in the expression profiles of microRNAs (miRNAs) have been found in many cancers. | 24390317 |
| Anaplastic astrocytoma | Epigenetic Alterations | Decreased expression of microRNA-206 correlates with poor clinical outcome in patients with malignant astrocytomas. | 24390803 |
| Malignant - descriptor, Neoplasms | Epigenetic Alterations | MicroRNA-206 (miR-206) has been proved to function as a tumor suppressor in several types of human malignant cancers. | 24390803 |
| Breast Carcinoma | Epigenetic Alterations | MiRNA profiling of approximately 380 miRNAs was performed on RNA derived from blood specimens from 10 women with breast cancer and 10 matched controls. | 24391813 |
| Malignant Neoplasms | Epigenetic Alterations | Their combined use to normalize expression data enabled the detection of altered target miRNA expression that reliably differentiated between cancers and controls in human blood specimens. | 24391813 |
| Breast Carcinoma | Epigenetic Alterations | Identification and validation of miRNAs as endogenous controls for RQ-PCR in blood specimens for breast cancer studies. | 24391813 |
| Neoplasms | Epigenetic Alterations | We also showed that there are different miRNA expression profiles associated with NPC for tumor tissue and sera. | 24393330 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Methods and matrices: approaches to identifying miRNAs for nasopharyngeal carcinoma. | 24393330 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer (CRC) arises as a consequence of genetic events such as gene mutation and epigenetic alteration. | 24393480 |
| ovarian neoplasm | Epigenetic Alterations | microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition. | 24394555 |
| Malignant Neoplasms, Meningioma | Epigenetic Alterations | To reveal any possible association between clinical features and promoter hypermethylation of O(6)-methylguanine-DNA methyltransferase (MGMT) as an important epigenetic modification in many human cancers, we also evaluated the methylation status of MGMT in meningiomas by a SYBR-green-based real-time PCR method. | 24398011 |
| Communicable Diseases, Hollings Cancer Center | Epigenetic Alterations | However, there was no significant correlation between aberrant DNA methylation of MMR genes or p16 and HCV infection in related HCC specimens. | 24400091 |
| Hepatocarcinogenesis | Epigenetic Alterations | However, the proposed HCV dependent promoter methylation of DNA mismatch repair (MMR) genes and thereby enhanced progression of hepatocarcinogenesis has been the subject of controversial discussion. | 24400091 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumour suppressor genes has been observed in various cancers. | 24400091 |
| B-Cell Lymphomas | Epigenetic Alterations | Clinical significance and detection of microRNA-21 in serum of patients with diffuse large B-cell lymphoma in Chinese population. | 24400911 |
| Autoimmune state | Epigenetic Alterations | Disturbed expression of microRNAs (miRNAs) in regulatory T cells (Tregs) leads to development of autoimmunity in experimental mouse models. | 24401767 |
| Neoplasms | Epigenetic Alterations | However, 20% of HPV DNA-positive tumors were negative for p16, with most of these tumors manifesting DNA methylation at the p16 gene promoter. | 24403267 |
| Initiation, Metastasis | Epigenetic Alterations | MicroRNAs (miRNAs) are directly involved in cancer initiation, progression and metastasis. | 24404590 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Our previous work described a metastasis-related microRNAs expression profiling and revealed miR-503 regulating metastatic function in hepatocellular carcinoma (HCC) cells. | 24405610 |
| Hematologic Neoplasms | Epigenetic Alterations | To determine the changes in the underlying epigenetic landscape responsible for this expression, we characterized expression, DNA methylation and histone modification profiles in 28 hematological cancer cell lines and confirmed the methylation signature in 356 cytogenetically well-characterized primary hematological malignancies. | 24405639 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Detectable expression of this gene is an excellent marker for minimal residual disease in acute myeloid leukemia (AML), but the underlying epigenetic alterations are unknown. | 24405639 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Despite high expression of WT1 and AWT1 transcripts in AML-derived cell lines, we observe robust hypermethylation of the AWT1 promoter and an epigenetic switch from a permissive to repressive chromatin structure between normal cells and AML cell lines. | 24405639 |
| Cervical Squamous Cell Carcinoma | Epigenetic Alterations | Differentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and after surgery. | 24405714 |
| Female Genital Diseases | Epigenetic Alterations | Finally, we depicted a regulatory network of differentially expressed serum miRNAs, and many possible target genes were predicted in the estrogen-mediated signal pathways, supporting the hypothesis that cervical SCC is a hormone-associated gynecological disease. | 24405714 |
| Neoplasms | Epigenetic Alterations | The survival and colonization of tumor cells at new locations involve a variety of complex genetic, epigenetic, and microenvironmental factors. | 24409330 |
| Glioma, Neoplasms, Glioblastoma Multiforme | Epigenetic Alterations | Comparing miRNA expression between glioblastoma group and gliomas of grades I-III, 3 miRNAs (miR-10b, mir-34a and miR-101) showed different regulation statuses between high-grade and low-grade tumors. | 24412053 |
| Neoplastic disease, Glioblastoma Multiforme | Epigenetic Alterations | This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs. | 24412053 |
| Neoplastic disease, Glioblastoma Multiforme | Epigenetic Alterations | Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I-III. | 24412053 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs could represent putative target molecules, considering their role in tumorigenesis, cancer progression and their specific tissue expression. | 24412053 |
| Neoplasms | Epigenetic Alterations | Analysis of expression of microRNAs and genes involved in the control of key signaling mechanisms that support or inhibit development of brain tumors of different grades. | 24412320 |
| Glioblastoma | Epigenetic Alterations | Different miRNAs with pro-oncogenic and anti-oncogenic properties have been identified in glioblastomas. | 24412320 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | We also measured expression of six key genes such as PTEN, p21/CDKN1A, MDR1, ABCG2, BAX, and BCL-2 involved in the regulation of critical glioma signaling pathways to establish the effect of miRNAs on these signaling mechanisms. | 24412320 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | These observations provide new insights into molecular pathogenic mechanisms of glioma progression and suggest about a potential value of miRNAs as a putative diagnostic marker of brain tumors. | 24412320 |
| Inflammatory disorder | Epigenetic Alterations | Serum levels of microRNA have been proposed as biomarkers in various inflammatory diseases. | 24413579 |
| Septicemia | Epigenetic Alterations | Among all regulated microRNAs, miR-133a displayed the most prominent and concordant up-regulation in sepsis, and this microRNA was therefore chosen for further investigation in the human. | 24413579 |
| SF3B1 wt Allele | Epigenetic Alterations | Our data show consistency in patterns of aberrant DNA methylation in human and mouse MDS and suggest that epigenetically, MDS displays an accelerated aging phenotype. | 24414704 |
| Papillary thyroid carcinoma, Primary malignant neoplasm, F9 gene | Epigenetic Alterations | Aberrant DNA methylation is known to be a major factor in oncogenesis and cancer progression, but effects of methylation in papillary thyroid cancer (PTC) are not well defined. | 24423287 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | The expression of miR-21 and miR-126 was analysed in a large cohort of RCC patients; a combined risk score (CRS)-model was constructed based on expression levels of both miRNAs. | 24428907 |
| Extracellular Matrix | Epigenetic Alterations | miRNASeq revealed 160 and 147 differentially expressed miRNAs in ICM and NICM, respectively, compared with nonfailing LV. | 24429688 |
| Extracellular Matrix | Epigenetic Alterations | Among these, only 2 (ICM) and 5 (NICM) miRNAs are normalized with LVAD. | 24429688 |
| Autoimmune thrombocytopenia | Epigenetic Alterations | Aberrant histone methylation in the patients with immune thrombocytopenia. | 24433164 |
| Colorectal Carcinoma | Epigenetic Alterations | It is uncertain whether synchronous colorectal cancers (S-CRCs) preferentially develop through widespread DNA methylation and whether they have a prognosis worse than solitary CRC. | 24434431 |
| Encyclopedias | Epigenetic Alterations | Furthermore, the targets of this microRNA were predicted through the gateway miRecords and mapped to lung cancer-associated pathways using the KEGG (Kyoto Encyclopedia of Genes and Genomes) database. | 24438615 |
| Small cell carcinoma of lung, sq. in | Epigenetic Alterations | MicroRNA-205 yielded high diagnostic accuracy in discriminating SQ from AC with an area under the curve (AUC) of 0.985, and discriminating SQ from SCLC with an AUC of 0.978 in formalin-fixed paraffin-embedded (FFPE) surgical lung tissues. | 24438615 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer. | 24439061 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | To analyze microRNA profile in Ta and T1 urinary bladder cancers in combination and separately and to relate this to the risk of later developing higher-stage disease. | 24439061 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Formalin-fixed, paraffin-embedded samples of 44 Ta and 42 T1 bladder cancers representing cases with and without stage progression during follow-up were collected and microRNA expression levels were measured by microarray analysis. | 24439061 |
| Malignant Neoplasms | Epigenetic Alterations | The comparison concerning microRNA expression between the progressors and controls in category T1 cancers revealed no significant differences. | 24439061 |
| Neoplasms | Epigenetic Alterations | Lower miR-10a-5p expression in Ta progressing tumors indicates that this microRNA could be important for later malignant potential among this group of patients. | 24439061 |
| Malignant Neoplasms | Epigenetic Alterations | Profiling revealed that certain microRNAs predicted the risk of developing higher-stage disease among patients with Ta cancers. | 24439061 |
| Ocular Sebaceous Carcinoma | Epigenetic Alterations | Hypermethylation of the CDKN2A gene promoter is a frequent epigenetic change in periocular sebaceous carcinoma and is associated with younger patient age. | 24440092 |
| Ocular Sebaceous Carcinoma | Epigenetic Alterations | In order to clarify and explore the molecular and epigenetic basis of HPV, CDKN2A status and role of microsatellite instability in the development of periocular sebaceous carcinoma, 24 cases of periocular sebaceous carcinoma were analyzed for the expression of p16(INK4a) and mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2) via immunohistochemistry. | 24440092 |
| Neoplasms | Epigenetic Alterations | Higher frequency of CDKN2A promoter hypermethylation in younger patients implies a significant epigenetic role in tumor development in this age group. | 24440092 |
| Adrenal Cortical Adenoma, hyperfunction | Epigenetic Alterations | MicroRNA expression patterns associated with hyperfunctioning and non-hyperfunctioning phenotypes in adrenocortical adenomas. | 24446485 |
| Alcohol abuse | Epigenetic Alterations | The results suggest that miRNA expression profiles can distinguish different subtypes of ACA, which may contribute to a deeper understanding of ACA development and potential therapeutics. | 24446485 |
| Neoplasms | Epigenetic Alterations | Significance analysis of microarrays (SAM) was carried out to identify differentially expressed miRNAs between ACA and adrenal cortices or between tumor subtypes. | 24446485 |
| Adenoma | Epigenetic Alterations | SAM analysis identified 40 over-expressed and three under-expressed miRNAs in the adenomas as compared with adrenal references. | 24446485 |
| Alcohol abuse | Epigenetic Alterations | Fourteen miRNAs were common among the three ACA subtypes. | 24446485 |
| Neoplasms | Epigenetic Alterations | Furthermore, we found specific miRNAs associated with different tumor phenotypes. | 24446485 |
| Crohn Disease | Epigenetic Alterations | microRNAs (miRNAs) have been suggested to be candidates for biomarkers in various diseases including Crohns disease (CD). | 24447044 |
| Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma | Epigenetic Alterations | [Significance of microRNA-16 and bcl-2 expression in T lymphoblastic lymphoma/leukemia and its relation with prognosis]. | 24447552 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Prognostic value of microRNA expression in operable non-small cell lung cancer patients. | 24448358 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We assessed by quantitative reverse transcription PCR microRNA (miRNA) expression in 273 stage I-IIIA NSCLC samples. | 24448358 |
| SERPINB3 wt Allele | Epigenetic Alterations | In the second step, miRNAs with highest predictive value for distant relapse were re-evaluated in formalin-fixed paraffin-embedded material in an independent group of 134 stage I-IIIA SCC patients. | 24448358 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA biomarkers in whole blood for detection of pancreatic cancer. | 24449318 |
| Pancreatic carcinoma, Pancreatitis, Primary malignant neoplasm | Epigenetic Alterations | To describe differences in microRNA expression in whole blood between patients with pancreatic cancer, chronic pancreatitis, and healthy participants and to identify panels of microRNAs for use in diagnosis of pancreatic cancer compared with the cancer antigen 19-9 (CA19-9). | 24449318 |
| Pancreatic carcinoma | Epigenetic Alterations | Identification of microRNA panels (classifiers) for diagnosing pancreatic cancer. | 24449318 |
| Pancreatic carcinoma | Epigenetic Alterations | The discovery cohort demonstrated that 38 microRNAs in whole blood were significantly dysregulated in patients with pancreatic cancer compared with controls. | 24449318 |
| Rheumatoid Arthritis, Inflammation | Epigenetic Alterations | A novel p53/microRNA-22/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis. | 24449575 |
| Autoimmune Diseases | Epigenetic Alterations | Our results not only reveal a novel mechanism whereby p53 is involved in the posttranscriptional regulation of Cyr61 expression via miRNA-22, but also provide a molecular explanation for the role of somatic mutations of p53, which are frequently observed in RA synovial tissue, in the etiology of this autoimmune disease. | 24449575 |
| Degenerative polyarthritis | Epigenetic Alterations | To investigate the role of the newly discovered epigenetic mark 5-hydroxymethylcytosine (5hmC) and its regulators in altered gene expression in osteoarthritis (OA). | 24449578 |
| Degenerative polyarthritis | Epigenetic Alterations | This study provides the first evidence of an epigenetic imbalance of the 5hmC homeostasis in OA leading to TET1 down-regulation and 5hmC accumulation. | 24449578 |
| Vasa Previa, atherosclerotic | Epigenetic Alterations | Aberrant DNA methylation of the analyzed loci was not established in either the atherosclerotic plaques and in the tissues from the macroscopically unchanged previa vascular wall in the same patients. | 24450202 |
| Primary malignant neoplasm | Epigenetic Alterations | microRNAs (miRNAs) are aberrantly expressed in the whole blood of patients suffering from different types of cancer. | 24452363 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-30c serves as an independent biochemical recurrence predictor and potential tumor suppressor for prostate cancer. | 24452717 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-30c (miR-30c) acts as a tumor suppressor or a tumor promoter in various human malignancies. | 24452717 |
| Antilymphocyte Serum | Epigenetic Alterations | These results demonstrate that the expression of two miRNAs (miRNAs miR-b1336 and miR-b2403) whose effect is to stabilize NEFL mRNA are down regulated in ALS, the net effect of which is predicted to contribute directly to the loss of NEFL steady state mRNA which is pathognomic of spinal motor neurons in ALS. | 24454911 |
| Carcinoma of lung | Epigenetic Alterations | miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1. microRNAs (miRNAs) are a class of endogenously expressed, small non-coding RNAs that play an important role in the regulation of gene expression at the post-transcriptional level. | 24456795 |
| Carcinoma of lung, Disease | Epigenetic Alterations | Dysregulation of miRNAs is associated with a variety of diseases, including lung cancer. | 24456795 |
| 1-methyl-1-piperidinomethane sulfonate, Malignant Pleural Mesothelioma, Neoplasms | Epigenetic Alterations | Epigenetic inactivation of tumor suppressor genes is involved in the development of malignant pleural mesothelioma (MPM). | 24457242 |
| diabetic | Epigenetic Alterations | These results suggest that epigenetic interventions may reverse alterations in human CMSC obtained from diabetic patients. | 24458358 |
| Stomach Carcinoma | Epigenetic Alterations | Tumor-associated microRNAs have been detected in serum or plasma, but whether plasma microRNA-21 (miR-21) could be a potential circulating biomarker for gastric cancer (GC) prognosis in Chinese is still uncertain. | 24460332 |
| Atrial Fibrillation | Epigenetic Alterations | In conclusion, miR-150 expression levels in platelets of patients with systolic HF with AF are significantly reduced and correlated to the cell-free circulating levels of this miRNA. | 24462065 |
| Primary malignant neoplasm | Epigenetic Alterations | In conclusion, we provide evidence that DNA damage responsive microRNAs are frequently misexpressed in human cancer and can modulate chemotherapy sensitivity. | 24462518 |
| Malignant Neoplasms | Epigenetic Alterations | In recent years the investigation of malignancy genomics (genetic and epigenetic changes) has become the main focus of scientists because of its high sensitivity and specificity. | 24464006 |
| Esophageal Basaloid Carcinoma | Epigenetic Alterations | Downregulation of sFRP-2 by epigenetic silencing activates the b-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. | 24464051 |
| NEFH gene, Neoplasms | Epigenetic Alterations | DNA methylation of the NEFH promoter and loss of expression have previously been shown to activate the AKT/b-catenin pathway in tumor cells. | 24464810 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | We identified NEFH methylation as a candidate epigenetic marker for prognosis of RCC patients as well as prediction of anti-vascular endothelial growth factor-based therapy response. | 24464810 |
| Hepatitis B, Liver carcinoma | Epigenetic Alterations | Aberrant DNA methylation of G-protein-coupled bile acid receptor Gpbar1 (TGR5) is a potential biomarker for hepatitis B Virus associated hepatocellular carcinoma. | 24465162 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | MicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer. | 24465504 |
| Tetranitromethane, Metastasis | Epigenetic Alterations | These patients showed a significantly more advanced stage (TNM stage >= IB, 35.0% vs. 12.8%, p = 0.045) and higher rate of LN metastasis (30.0% vs. 5.1%, p = 0.014) than those with up-regulation of miRNA-135a expression. | 24465504 |
| Metastasis | Epigenetic Alterations | Our results confirm the tumor-suppressive role of miRNA-135a, and demonstrate its role in LN metastasis in EGC. | 24465504 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | MicroRNAs (miRNAs) play a critical role in gastric cancer progression and metastasis. | 24465504 |
| Breast Carcinoma, ovarian neoplasm, Neoplasms | Epigenetic Alterations | MicroRNA-214 (MiR-214) is aberrantly expressed in several human tumors such as ovarian cancer and breast cancer. | 24465927 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Then the expressions of microRNAs (miRNAs) in six pairs of colorectal cancer and normal tissues were determined by miRNA array, and 30 up-regulated miRNAs were found in the colorectal cancer tissues. | 24468585 |
| Breast Carcinoma | Epigenetic Alterations | Association of microRNAs and pathologic response to preoperative chemotherapy in triple negative breast cancer: preliminary report. | 24469723 |
| Prostatic Hyperplasia | Epigenetic Alterations | MicroRNAs 143 and 145 may be involved in benign prostatic hyperplasia pathogenesis through regulation of target genes and proteins. | 24474452 |
| Hyperhomocysteinemia, Cardiovascular Diseases | Epigenetic Alterations | DNA methylation of repetitive elements may explain the relations between dietary intake, hyperhomocysteinemia, and cardiovascular disease risk. | 24477006 |
| Malignant Neoplasms, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Aberrant expression of microRNAs (miRNAs) has been associated with the pathogenesis of various cancers, including PCa. | 24477576 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulatory forms of miRNAs have been detected in serum and hold promise as minimally invasive cancer biomarkers. | 24477576 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Candidate serum miRNAs were detected by using PCR microarray in a learning set of six African American (AA) and six Caucasian American (CA) PCa patients. | 24477576 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our results demonstrate that the three miRNAs, particularly miR-628-5p, may be further developed as a biomarker, which can serve as novel noninvasive biomarker for PCa diagnosis and prognosis. | 24477576 |
| Diabetes Mellitus, Non-Insulin-Dependent, Sensitization (observable entity) | Epigenetic Alterations | Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization. | 24478399 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | A discriminant function of four miRNAs (miR-140-5p, miR-423-5p, miR-195, and miR-126) was specific for T2D with an accuracy of 89.2% (P < 0.0001). | 24478399 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer. | 24479446 |
| Breast Carcinoma | Epigenetic Alterations | miRNAs have emerged as an attractive candidate for molecular biomarkers and treatment targets in breast cancer, but their role in the progression of triple negative breast cancer remains largely unexplored. | 24479446 |
| Breast Carcinoma | Epigenetic Alterations | 71 miRNAs were differentially expressed in triple negative breast cancer, the majority of which have previously been associated with breast cancer, including members of the miR-200 family and the miR-17-92 oncogenic cluster, suggesting that the majority of miRNAs involved in the initiation of triple negative breast cancer are not subtype specific. | 24479446 |
| Malignant neoplasm of breast | Epigenetic Alterations | However, the repertoire of miRNAs expressed in lymph node negative and lymph node positive triple negative breast cancers were largely distinct from one another. | 24479446 |
| Breast Carcinoma | Epigenetic Alterations | From this, 27 miRNAs were identified that are associated with metastatic capability in the triple negative breast cancer subtype. | 24479446 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | These results provide novel insight into the repertoire of miRNAs that contribute to the initiation of and progression to lymph node metastasis in triple negative breast cancer and have important implications for the treatment of this breast cancer subtype. | 24479446 |
| ovarian neoplasm | Epigenetic Alterations | Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer. | 24479488 |
| ovarian neoplasm | Epigenetic Alterations | Both genetic and epigenetic factors influence the development and progression of epithelial ovarian cancer (EOC). | 24479488 |
| Neoplasms | Epigenetic Alterations | Using our previously developed BRCA1/2-signatures, we identified 7 non-BRCA1/2 tumors with a BRCA1-like molecular phenotype and provide evidence for epigenetic inactivation of BRCA1 in three of the tumors. | 24479546 |
| Pathological accumulation of air in tissues | Epigenetic Alterations | MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression. | 24479666 |
| Carcinoma of lung, Chronic Obstructive Airway Disease | Epigenetic Alterations | Resected lung from patients with COPD undergoing lung cancer surgery was profiled using miRNA (Agilent Human miRNA profiler G4470 V1.01) and mRNA (OperonV2.0) microarrays. | 24479666 |
| Chronic Obstructive Airway Disease, Pathological accumulation of air in tissues | Epigenetic Alterations | Differences in miRNA expression are associated with emphysema severity in COPD patients. | 24479666 |
| Pathological accumulation of air in tissues | Epigenetic Alterations | Five miRNAs (miR-34c, miR-34b, miR-149, miR-133a and miR-133b) were significantly down-regulated in lung from patients with moderate compared to mild emphysema as defined by gas transfer (p < 0.01). | 24479666 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | miRNA profiling was performed on 12 pairs of samples of gastric cancer with distant metastasis (GC/DM) and gastric cancer with no distant metastasis (GC/NDM); 14 differentially expressed miRNAs were identified for further inspection. | 24481716 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. | 24481854 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Although miR-10b was identified as an miRNA deregulator expressed in gastric cancer (GC), there also exists some debate on whether miR-10b is acting as tumor suppressor or oncogene in GC. | 24481854 |
| Neoplasms | Epigenetic Alterations | MicroRNAs act as tumor suppressors or oncogenes. | 24481854 |
| Triple Negative Breast Neoplasms | Epigenetic Alterations | Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis. | 24485087 |
| Triple Negative Breast Neoplasms | Epigenetic Alterations | This study provides evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrates that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation. | 24485087 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | In conclusion, functional and epigenetic alterations of COPD fibroblasts can be reprogrammed through formation of iPSCs. | 24487392 |
| Malignant Neoplasms | Epigenetic Alterations | The mitogen-activated protein kinase (MAPK) and AKT signaling pathways are downstream of EGFR and deregulated via genetic and epigenetic mechanisms in many human cancers. | 24487999 |
| Polycystic Kidney, Autosomal Dominant | Epigenetic Alterations | Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline. | 24489795 |
| Polycystic Kidney, Autosomal Dominant | Epigenetic Alterations | Expression of the dysregulated miRNA in fetal tubule epithelia resembled ADPKD better than normal adult cells, except let-7i, which was lower in fetal cells. | 24489795 |
| Kidney Neoplasm, Polycystic Kidney, Autosomal Dominant, Chronic Kidney Diseases | Epigenetic Alterations | We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. | 24489795 |
| Polycystic Kidney, Autosomal Dominant | Epigenetic Alterations | Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. | 24489795 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | We found this repressive association in 6/6 patient tumor samples of different Gleason score, suggesting a strong interplay of DNA methylation and EZH2 to silence RARb during prostate tumorigenesis. | 24492483 |
| Heat (physical force) | Epigenetic Alterations | Here we examine genome-wide DNA methylation, first in 50 identical twins discordant for heat pain sensitivity and then in 50 further unrelated individuals. | 24496475 |
| Low Back Pain, Feel Pain | Epigenetic Alterations | Whole-blood DNA methylation was characterized at 5.2 million loci by MeDIP sequencing and assessed longitudinally to identify differentially methylated regions associated with high or low pain sensitivity (pain DMRs). | 24496475 |
| Feel Pain | Epigenetic Alterations | Our approach identifies epigenetic changes in both novel and established candidate genes that provide molecular insights into pain and may generalize to other complex traits. | 24496475 |
| Cholangiocarcinoma | Epigenetic Alterations | Human bile contains microRNA-laden extracellular vesicles that can be used for cholangiocarcinoma diagnosis. | 24497320 |
| Disease | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) are key regulatory molecules involved in a variety of biological processes and human diseases. | 24497937 |
| Breast Carcinoma | Epigenetic Alterations | Identification and validation of oncologic miRNA biomarkers for luminal A-like breast cancer. | 24498016 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MiRNAs play regulatory roles in tumor initiation and progression, and altered miRNA expression has been demonstrated in a variety of cancer states presenting the potential for exploitation as cancer biomarkers. | 24498016 |
| Mammary Neoplasms | Epigenetic Alterations | The biomarker potential of 4 miRNAs (miR-29a, miR-181a, miR-223 and miR-652) was confirmed by RQ-PCR, with significantly reduced expression in blood of women with Luminal A-like breast tumors compared to healthy controls (p = 0.001, 0.004, 0.009 and 0.004 respectively). | 24498016 |
| Malignant Neoplasms | Epigenetic Alterations | Binary logistic regression confirmed that combination of 3 of these miRNAs (miR-29a, miR-181a and miR-652) could reliably differentiate between cancers and controls with an AUC of 0.80. | 24498016 |
| Breast Carcinoma | Epigenetic Alterations | From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. | 24498016 |
| Mammary Neoplasms | Epigenetic Alterations | The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection. | 24498016 |
| Primary malignant neoplasm, Neoplasm Metastasis | Epigenetic Alterations | MicroRNAs (miRNAs) are small, single-stranded, non-coding RNAs that play pivotal roles in human cancer development and progression, such as tumor metastasis. | 24498348 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Here, we identified the miRNAs that regulate hepatocellular carcinoma (HCC) cell migration by a high-throughput screening method using the classical wound-healing assay with time-lapse video microscopy and validation with a transwell migration assay. | 24498348 |
| Hollings Cancer Center | Epigenetic Alterations | Eleven miRNAs (miR-134, -146b-3p, -188-3p, -525-3p, -661, -767-5p, -891a, -891b, -1244, -1247 and miR-1471) were found to promote or inhibit HCC cell migration. | 24498348 |
| Clinical Coordinator | Epigenetic Alterations | Present results support the hypothesis that DNA methylation in CRC depends from both physiological and environmental factors, with one-carbon metabolism largely involved in this process. | 24500500 |
| Cerebrovascular accident, Obesity | Epigenetic Alterations | Epigenetic patterns of two gene promoters (TNF-a and PON) in stroke considering obesity condition and dietary intake. | 24500802 |
| Cerebrovascular accident | Epigenetic Alterations | Some causal bases of stroke remain unclear, but the nutritional effects on the epigenetic regulation of different genes may be involved. | 24500802 |
| methionine, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. | 24500968 |
| ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | To define the genome-wide pattern of DNA methylation in pancreatic ductal adenocarcinomas (PDAC), we captured the methylation profiles of 167 untreated resected PDACs and compared them to a panel of 29 adjacent nontransformed pancreata using high-density arrays. | 24500968 |
| methionine | Epigenetic Alterations | Bisulfite amplicon deep sequencing and qRT-PCR expression analyses confirmed recurrent perturbation of axon guidance pathway genes SLIT2, SLIT3, ROBO1, ROBO3, ITGA2 and MET and suggests epigenetic suppression of SLIT-ROBO signaling and up-regulation of MET and ITGA2 expression. | 24500968 |
| Chordoma | Epigenetic Alterations | Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma. | 24501096 |
| Stomach Carcinoma, S100A4 protein, human | Epigenetic Alterations | The malignant transformation in gastric cancer is a multistep, complex process caused by numerous genetic and epigenetic changes, and smoking habits clearly effects on the predisposition to gastric cancer. | 24501797 |
| Ductal Carcinoma | Epigenetic Alterations | Epigenetic regulation of DNMT1 was assessed in 85 invasive ductal carcinomas from BRCA1 mutation carriers. | 24502362 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Our work showed the importance of the methylation status of the PDGF-B gene promoter, and suggests that the epigenetic regulation of the PDGF-B gene may serve as a potential therapeutic target for the inhibition of glioma proliferation. | 24502980 |
| Coinfection, Primary malignant neoplasm | Epigenetic Alterations | Our study shows the first evidence of miRNAs specific for co-infection, several of which are correlated with key gene targets demonstrating functional relationships to pathways in cancer, immune-function, and metabolism. | 24503097 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA signature in metastatic colorectal cancer patients treated with anti-EGFR monoclonal antibodies. | 24503111 |
| ras GTPase-Activating Proteins, Primary malignant neoplasm | Epigenetic Alterations | Despite the voluminous body of observational evidence concerning the role of miRNAs in cancer, significant knowledge gaps remain concerning the molecular circumstances that underlie the miRNA-cancer connection. | 24503492 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Identification of biomarkers that predict responses to hypomethylating agents (HMAs) will allow optimal strategies for epigenetic therapy in myelodysplastic syndromes (MDS) to be established. | 24503739 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Serum microRNA-21 as a potential biomarker for response to hypomethylating agents in myelodysplastic syndromes. | 24503739 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNAs (miRNAs) regulate the biological properties of colorectal cancer (CRC) cells and might serve as potential prognostic factors and therapeutic targets. | 24504363 |
| Clinical Coordinator | Epigenetic Alterations | In this study, we therefore globally profiled miRNAs associated with E-cadherin expression in CRC cells in an attempt to identify miRNAs that are associated with aggressive clinical course in CRC patients. | 24504363 |
| Clinical Coordinator | Epigenetic Alterations | Two CRC cell lines (Caco-2 and HRT-18) with different E-cadherin expression pattern were profiled for differences in abundance for more than 1000 human miRNAs using microarray technology. | 24504363 |
| Childhood Leukemia | Epigenetic Alterations | microRNA-34a (miRNA-34a) plays an important role in the pathogenesis of leukemia. | 24504520 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. | 24504682 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | A large number of genetic and epigenetic alterations have been found in gastric cancer, but there is remarkably little consensus on the value of individual biomarker in diagnosis and prognosis of this cancer. | 24505629 |
| Heart failure | Epigenetic Alterations | Transcoronary gradient of plasma microRNA 423-5p in heart failure: evidence of altered myocardial expression. | 24506564 |
| Heart failure | Epigenetic Alterations | Elevated plasmatic microRNAs (miRs) are observed in heart failure (HF). | 24506564 |
| Glioblastoma, Primary malignant neoplasm | Epigenetic Alterations | Genetic and epigenetic profiling of glioblastomas has provided a comprehensive list of altered cancer genes of which only O(6)-methylguanine-methyltransferase (MGMT) methylation is used thus far as a predictive marker in a clinical setting. | 24510240 |
| Glioblastoma Multiforme | Epigenetic Alterations | We screened 98 human glioblastoma samples for genetic and epigenetic alterations in 10 genes and chromosomal loci by PCR and multiplex ligation-dependent probe amplification (MLPA). | 24510240 |
| Glioblastoma Multiforme | Epigenetic Alterations | We tested the association between these genetic and epigenetic alterations and glioblastoma patient survival. | 24510240 |
| Stomach Carcinoma | Epigenetic Alterations | Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. | 24510342 |
| Carcinogens | Epigenetic Alterations | Several miRNAs differentially expressed between HGSC, CCC and OSE have been identified, suggesting a carcinogenetic role for these miRNAs. | 24512620 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The number of CA tandem repeats (CA)n in a highly polymorphic region of EGFR (epidermal growth factor receptor) intron 1 may affect gene transcription; the potential impact of allelic variants on the efficacy of cetuximab in metastatic colorectal cancer (mCRC) patients is debated for long. | 24513691 |
| Asthma Pathway, IL13 gene | Epigenetic Alterations | Altered microRNA expression of nasal mucosa in long-term asthma and allergic rhinitis. | 24513959 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | However, little is known about the differences in miRNA expression in patients with chronic allergic airway disease. | 24513959 |
| Asthma Pathway | Epigenetic Alterations | With regard to asthma severity, a trend of increased miRNA expression in persistent asthma was seen, whereas the downregulation of certain miRNAs was most distinct in nonpersistent-asthma patients. | 24513959 |
| Acute myocardial infarction | Epigenetic Alterations | To confirm these data, we compared selected miRNAs in the plasma of patients with bevacizumab-induced cardiotoxicity with those of 66 patients with acute myocardial infarction (AMI). | 24515657 |
| Cardiotoxicity | Epigenetic Alterations | We identify two miRNAs that are specifically elevated in patients with bevacizumab-induced cardiotoxicity, miR1254 and miRNA579, and miRNA1254 shows the strongest correlation to the clinical diagnosis of bevacizumab-induced cardiotoxicity. | 24515657 |
| Degenerative polyarthritis | Epigenetic Alterations | miRNA-454 was inversely correlated with severe knee or hip osteoarthritis with an adjusted HR of 0.77 (95% CI 0.61 to 0.97; p=0.028) when normalised to U6. | 24515954 |
| Degenerative polyarthritis | Epigenetic Alterations | Signature of circulating microRNAs in osteoarthritis. | 24515954 |
| Degenerative polyarthritis | Epigenetic Alterations | Among these microRNAs, let-7e emerged as potential predictor for severe knee or hip osteoarthritis. | 24515954 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11. | 24516043 |
| Neoplasms | Epigenetic Alterations | SLC7A11 protein and mRNA, and miRNA-27a were quantified in patient tumor material. | 24516043 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Our findings indicate that miRNA-27a negatively regulates SLC7A11 in cisplatin-resistant bladder cancer, and shows promise as a marker for patients likely to benefit from cisplatin-based chemotherapy. | 24516043 |
| Chronic Kidney Diseases | Epigenetic Alterations | Epigenetic mechanisms may be important in the progression of chronic kidney disease (CKD). | 24516231 |
| Renal function, Chronic Kidney Diseases | Epigenetic Alterations | Epigenetic modifications may be important in determining the rate of loss of kidney function in patients with established CKD. | 24516231 |
| Prostate Cancer Pathway | Epigenetic Alterations | Recent evidence suggests that the prostate cancer (PCa)-specific up-regulation of certain genes such as AMACR, EZH2, PSGR, PSMA and TRPM8 could be associated with an aberrant expression of non-coding microRNAs (miRNA). | 24517338 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Consequently, miRNAs could contribute to oncogenesis and progression of PCa via an altered miRNA-target gene-interaction. | 24517338 |
| Colorectal Neoplasms | Epigenetic Alterations | Validation of methylation-sensitive high-resolution melting (MS-HRM) for the detection of stool DNA methylation in colorectal neoplasms. | 24518356 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Methylation-sensitive high-resolution melting (MS-HRM) is a new technique for assaying DNA methylation, but its feasibility for assaying stool in patients with colorectal cancer (CRC) is unknown. | 24518356 |
| Prostate Cancer Pathway | Epigenetic Alterations | Aberrant miRNA expression is associated with prostate cancer pathogenesis. | 24518785 |
| Prostate Cancer Pathway | Epigenetic Alterations | We identified miRNAs as potential biomarkers for prostate cancer diagnosis and prognosis. | 24518785 |
| Colorectal Cancer Pathway | Epigenetic Alterations | To identify dysregulated microRNA(miRNA) that can act as novel biomarker for colorectal cancer screening. | 24519049 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The microRNA expression signature of bladder cancer by deep sequencing: the functional significance of the miR-195/497 cluster. | 24520312 |
| Malignant neoplasm of urinary bladder, Best Case Imputation Technique | Epigenetic Alterations | We determined the genome-wide miRNA expression signature in bladder cancer (BC) by deep sequencing technology. | 24520312 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Tumor suppressive miRNA-mediated cancer pathways provide new insights into the potential mechanisms of BC oncogenesis. | 24520312 |
| NBEA gene | Epigenetic Alterations | Among the known miRNAs, a total of 60 miRNAs were significantly downregulated in BC compared with NBE. | 24520312 |
| Metastasis | Epigenetic Alterations | In conclusion, aberrant expression of clustered miRNAs was identified by deep sequencing, and downregulation of miR-195/497 contributed to BC progression and metastasis. | 24520312 |
| Ulcerative Colitis, Neoplasms | Epigenetic Alterations | Notably, the TET2 epigenetic regulator was one of only two genes more frequently methylated in superficial tumors and the sole gene in low grade UC. | 24521710 |
| Pyelonephritis | Epigenetic Alterations | Acute pyelonephritis in renal allografts: a new role for microRNAs? | 24521778 |
| Clinical Coordinator | Epigenetic Alterations | Moreover, we found the expression of miR-31, a short non-coding RNA which played a critical role in CRC development, was negatively correlated with FIH-1 expression in CRC samples and cell lines. | 24521875 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-31 contributes to colorectal cancer development by targeting factor inhibiting HIF-1a (FIH-1). | 24521875 |
| Stomach Carcinoma | Epigenetic Alterations | However, the significance of lncRNA, especially long intergenic ncRNA (lincRNA, the main type of lncRNA family), in the diagnosis of gastric cancer is largely unknown. | 24523021 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | This study was designed to detect aberrant miRNA expressions as a potential biomarker for early detection and prognosis prediction of non-small cell lung cancer (NSCLC). | 24523873 |
| Neoplasms | Epigenetic Alterations | A similar effect was seen in tumours with epigenetic BRCA-1 silencing. | 24526178 |
| Meningioma, Neoplasms | Epigenetic Alterations | Epigenetic biomarkers such as DNA methylation, which is found in many tumors and is thus important in tumorigenesis can help diagnose meningiomas and predict response to adjuvant chemotherapy. | 24528051 |
| Childhood Leukemia, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation of tumor suppressor genes has been reported in all major types of leukemia with potential involvement in the inactivation of regulatory cell cycle and apoptosis genes. | 24528084 |
| Acute lymphocytic leukemia, Myeloid Leukemia, Chronic, Chronic Lymphocytic Leukemia, Childhood Leukemia, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Here, we analyzed six key genes (p14, p15, p16, p53, DAPK and TMS1) for DNA methylation using methylation specific PCR to analyze peripheral blood of 78 leukemia patients (24 CML, 25 CLL, 12 AML, and 17 ALL) and 24 healthy volunteers. | 24528084 |
| Esophageal carcinoma, Squamous cell carcinoma of esophagus | Epigenetic Alterations | To determine whether aberrant miR-34a methylation occurs in esophageal cancer, the DNA methylation of 23 CpGs sites in the miR-34a promoter was quantitatively analyzed in relation to the translation initiation site by MALDI -TOF mass spectrometry in 59 ESCC tissues and 34 normal tissues from the Kazakh population. | 24528540 |
| Hollings Cancer Center | Epigenetic Alterations | Methylation-specific sequencing and methylation-specific PCR were performed to examine DNA methylation status of the CHD5 promoter in HCC cell lines and samples. | 24529164 |
| Hollings Cancer Center | Epigenetic Alterations | In this study, we focused on the epigenetic modification and tumour-suppressive mechanism of CHD5 gene in HCC. | 24529164 |
| Hypermethylation | Epigenetic Alterations | This study is the first to report cerebellar hypermethylation in c9FTD/ALS, and the first to identify a c9FTD patient with aberrant DNA methylation. | 24530272 |
| Neurodegenerative Disorders | Epigenetic Alterations | Repeat expansions, also present in other neurodegenerative diseases, have been shown to alter epigenetic mechanisms and consequently lead to decreased gene expression, while also leading to toxic RNA gain-of-function. | 24530272 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Low expression of microRNA-126 is associated with poor prognosis in colorectal cancer. | 24532280 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-126 (miR-126) has been reported to be a tumor suppressor that targets CXCR4 in colorectal cancer (CRC) cells. | 24532280 |
| ovarian neoplasm | Epigenetic Alterations | Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer. | 24535937 |
| Aggressive behavior, Refractory Cytopenia of Childhood | Epigenetic Alterations | Epigenetic alterations in GATA family members may be associated with aggressive tumor phenotypes in RCC, and in the case of GATA5, may serve as a new independent molecular marker for aggressiveness and disease progression. | 24549248 |
| Liver carcinoma | Epigenetic Alterations | Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival. | 24549282 |
| Hollings Cancer Center | Epigenetic Alterations | The diagnostic value of plasma miRNA-139 for differentiating patients with HCC from the ones with chronic HBV-hepatitis (CH) was analyzed. | 24549282 |
| Hollings Cancer Center | Epigenetic Alterations | Compared with plasma of chronic HBV-hepatitis, miRNA-139 was lowly expressed in plasma of HCC patients (p<0.010). | 24549282 |
| Hollings Cancer Center | Epigenetic Alterations | ROC analysis of plasma miRNA-139 yielded an AUC of 0.764 (p<0.010) with sensitivity of 80.6% and specificity of 58.1% while differentiating HCC from chronic HBV-hepatitis. | 24549282 |
| Hollings Cancer Center | Epigenetic Alterations | Subsequently, 31 HCC patients were divided into the low or high expression group based on plasma miRNA-139 level. | 24549282 |
| Hollings Cancer Center | Epigenetic Alterations | miRNA-139 was downregulated in the cancerous tissue and plasma of HCC patients. | 24549282 |
| Hollings Cancer Center | Epigenetic Alterations | Plasma miRNA-139 is a diagnostic biomarker and prognostic factor for HCC. | 24549282 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) have been frequently reported to be diagnostic biomarkers and prognostic factors for cancer. | 24549282 |
| Hollings Cancer Center | Epigenetic Alterations | Epigenetic down-regulation of COL1A1 mRNA expression might have a role as a prognostic biomarker of HCC. | 24552139 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | DNA methylation plays an important role in cancer biology and methylation events are important prognostic and predictive markers in many tumor types. | 24554053 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | Epigenetic silencing of the LDOC1 tumor suppressor gene in ovarian cancer cells. | 24554348 |
| Autoimmune thyroid disease | Epigenetic Alterations | microRNA expressions in CD4+ and CD8+ T-cell subsets in autoimmune thyroid diseases. | 24554510 |
| Haiti | Epigenetic Alterations | Both GD and HT showed significantly decreased miRNA 200a_1 and miRNA 200a2* in CD4+-T-cells (mean relative expression 12,57 in HT vs. 19.40 in control group (CG), p=0.0002; 12,10 in GD vs. 19.40 in CG, p=0.0002) and in CD8+-T-cells (13.13 in HT vs. 18,12 in CG, p=0.02; 11.66 in GD vs. 18.12 in CG, p=0.0002). | 24554510 |
| Haiti | Epigenetic Alterations | GD and HT showed significantly decreased miRNA 155_2 and miRNA 155*_1 in HT in CD8+-T-cells (10.69 in HT vs. 11.30 in CG, p=0.01; 10.40 in GD vs. 11.30 in CG, p=0.005). | 24554510 |
| Thyroid Diseases | Epigenetic Alterations | They extend our very limited knowledge concerning miRNAs in thyroid diseases. | 24554510 |
| Alzheimers Disease | Epigenetic Alterations | DNA methylation of the TNF-a promoter region in peripheral blood monocytes and the cortex of human Alzheimers disease patients. | 24556805 |
| Admitting diagnosis | Epigenetic Alterations | In AD patients, epigenetic mechanisms of TNF-a gene regulation, like aberrant DNA methylation, are not relevant in blood. | 24556805 |
| Pathological accumulation of air in tissues | Epigenetic Alterations | A rat model of emphysema was induced by enforced smoking, and the dynamic miRNAs expression profile at different stages of emphysema with varying periods of smoking were analyzed by microarray and quantitative real-time polymerase chain reaction (qRT-PCR). | 24556821 |
| Pulmonary Emphysema | Epigenetic Alterations | Following smoking for varying periods, different severities of lung emphysema were observed in different groups of rats, accompanied by altered levels of some serum miRNAs associated with regulating some pathways. | 24556821 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic alterations, including histone modifications, play an important role during carcinogenesis. | 24556868 |
| methionine | Epigenetic Alterations | Histone methylation levels of MET resembled MIBC. | 24556868 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Epigenetic inactivation of mir-34b/c in addition to mir-34a and DAPK1 in chronic lymphocytic leukemia. | 24559316 |
| Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | Taken together, miR-34b/c is a tumor suppressor miRNA frequently methylated, and hence silenced in CLL. | 24559316 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Decreased expression of microRNA-200b is an independent unfavorable prognostic factor for glioma patients. | 24559637 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in cancer development and prognosis. | 24563077 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Profiling plasma microRNA in nasopharyngeal carcinoma with deep sequencing. | 24563490 |
| Neoplasms | Epigenetic Alterations | Epigenetic alterations, especially aberrant DNA methylation, are recognized as common molecular alterations in a variety of tumors and also occur during the development of tumors. | 24565108 |
| Primary malignant neoplasm | Epigenetic Alterations | CGPredictor: a systematic integrated analytic tool for mining and examining genome-scale cancer independent prognostic epigenetic marker panels. | 24565108 |
| Medullary carcinoma of thyroid | Epigenetic Alterations | Overexpression of genes involved in miRNA biogenesis in medullary thyroid carcinomas with RET mutation. | 24569963 |
| Primary malignant neoplasm | Epigenetic Alterations | Expression of genes encoding factors involved in miRNA biogenesis results often deregulated in human cancer and correlates with aggressive clinical behavior. | 24569963 |
| Aggressive behavior | Epigenetic Alterations | We then attempted to correlate expression of miRNA biogenesis genes with tumor aggressiveness. | 24569963 |
| Myeloid neoplasm | Epigenetic Alterations | BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression. | 24571310 |
| Skin Basal Cell Carcinoma | Epigenetic Alterations | Epigenetic alterations in sporadic basal cell carcinomas. | 24573469 |
| Breast Cancer Cell | Epigenetic Alterations | Recently, it has become evident that along with genetic mutations epigenetic alterations play a key role in the pathogenesis of human cancer. | 24573469 |
| Metastasis | Epigenetic Alterations | Moreover, our results revealed that abnormal DNA methylation of miR-34a was correlated with lymph metastasis (P = 0.010). | 24573638 |
| Carcinoma of lung | Epigenetic Alterations | mRNA and miRNA analyses in cytologically positive endobronchial ultrasound-guided transbronchial needle aspiration: implications for molecular staging in lung cancer patients. | 24574164 |
| Sjogrens Syndrome | Epigenetic Alterations | Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjogrens syndrome. | 24574234 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miR)-182 is frequently upregulated in cancers, has generally been viewed as an oncogene and is possibly connected to angiogenesis. | 24575749 |
| Admitting diagnosis | Epigenetic Alterations | Serum miRNA panel (or miR-342-3p alone) may serve as a novel, noninvasive biomarker for AD. | 24577456 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | DNA methylation of tumor suppressor genes (TSGs) represents a frequent and early epigenetic event with potential applications for cancer detection and disease evolution. | 24577895 |
| Breast Carcinoma | Epigenetic Alterations | Aberrant DNA methylation status of DNA repair genes in breast cancer treated with neoadjuvant chemotherapy. | 24581343 |
| Primary Neoplasm, Colorectal Cancer Pathway | Epigenetic Alterations | HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. | 24583926 |
| Neoplasms | Epigenetic Alterations | Long non-coding RNA HOTAIR (Homeobox Transcript Antisense Intergenic RNA) overexpression in tumors was previously associated with poor prognosis and higher mortality in different carcinomas. | 24583926 |
| Stomach Carcinoma | Epigenetic Alterations | We hoped to identify miRNA polymorphism or a combination of several polymorphisms that could serve as biomarkers for predicting the risk of gastric cancer and its precancerous diseases. | 24586594 |
| Pathology | Epigenetic Alterations | Circulating microRNAs (miRNAs) are emerging as promising biomarkers for several pathologies. | 24588811 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Aberrant DNA methylation plays an important role in genesis of colorectal cancer (CRC). | 24590867 |
| Small cell carcinoma of lung | Epigenetic Alterations | Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer. | 24591352 |
| Fragile X Syndrome | Epigenetic Alterations | Greater than 200 CGG repeats in the 5UTR of the FMR1 gene lead to epigenetic silencing and lack of the FMR1 protein, causing fragile X Syndrome. | 24591415 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA expression profiles of circulating microvesicles in hepatocellular carcinoma. | 24592541 |
| Neoplasms | Epigenetic Alterations | Microvesicles (MVs) packaged with microribonucleic acids (miRNAs) have been shown to be released mainly from tumor cells. | 24592541 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | However, little information is known for miRNAs from MVs in hepatocellular carcinoma (HCC). | 24592541 |
| Hollings Cancer Center | Epigenetic Alterations | Among them, 115 miRNAs were over-expressed with up to 31 fold difference (miR-671-5p) and 127 were down-expressed with up to 0.041 fold difference (miR-432) in HCC. | 24592541 |
| Hollings Cancer Center | Epigenetic Alterations | The deregulation of MVs miRNAs and their target genes were closely involved in the pathways of HCC. | 24592541 |
| Hollings Cancer Center | Epigenetic Alterations | Aberrant HCC-MVs miRNAs may play important roles in the development of HCC. | 24592541 |
| Liver carcinoma | Epigenetic Alterations | Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma. | 24593846 |
| Malignant Solid Neoplasm | Epigenetic Alterations | Accumulating evidence has shown that up-regulation of microRNA-25(miR-25) is associated with the prognosis of several types of human malignant solid tumors. | 24593846 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant global DNA methylation is shown to increase cancer risk. | 24595004 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The findings from this large-scale study suggest that both low and high levels of global DNA methylation are associated with the risk of bladder cancer. | 24595004 |
| Septicemia | Epigenetic Alterations | [Expression of microRNA-155 and regulative T cell in sepsis patients and their relationship]. | 24598292 |
| Carcinoma of lung | Epigenetic Alterations | Still, the prognosis remains poor, and we need to know more about the genetic and epigenetic alterations in lung cancer. | 24599520 |
| Adenocarcinoma of lung (disorder), Neoplasms | Epigenetic Alterations | 129 microRNAs were significantly differentially expressed in lung adenocarcinomas compared with normal lung tissue, and 17 microRNAs were differentially expressed between EGFR-mutated and EGFR wildtype tumors. | 24599520 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | We have identified several aberrantly expressed microRNAs that discriminate lung adenocarcinomas from normal lung tissue, and hence may be potential biomarkers for early detection. | 24599520 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | We have found microRNAs that are differentially expressed between EGFR-mutated and EGFR wildtype lung adenocarcinomas, suggesting that microRNAs can be used as molecular biomarkers in classification. | 24599520 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | CpG island methylator phenotype of myelodysplastic syndrome identified through genome-wide profiling of DNA methylation and gene expression. | 24601943 |
| Malignant Neoplasms | Epigenetic Alterations | The CpG island methylator phenotype (CIMP) is an epigenetic phenomenon and plays an important role in tumourigenesis in various cancers. | 24601943 |
| Ischemia | Epigenetic Alterations | Prolonged cold ischemia induces significant transcriptional changes in a small subset of transcripts in the tissue. | 24602449 |
| Childhood Leukemia | Epigenetic Alterations | microRNA-125b promotes leukemia cell resistance to daunorubicin by inhibiting apoptosis. | 24604579 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | microRNA-125b (miR-125b) is overexpressed in several types of cancer and contributes to tumor resistance to chemotherapy. | 24604579 |
| Primary malignant neoplasm | Epigenetic Alterations | However, it is in cancer that only two miRNAs of this cluster and its paralogues have been reported so far to regulate TGFbR2. | 24606633 |
| Metastasis | Epigenetic Alterations | A cluster set of 4 TGFbR2-associated miRNAs was identified; they are all from miR-17-92 cluster and its paralogues, of which miR-93 was one of the most significant miRNAs, directly targeting TGFbR2, promoting cell proliferation, invasion and metastasis in vitro and in vivo. | 24606633 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Our findings indicated that miR-199a-3p target HGF/c-Met signaling pathway which is crucial for RCC development and suggest that miR-199a-3p may serve as a potential target miRNA for RCC therapy. | 24609899 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Accumulating evidence suggests that miRNAs are involved in cancer development and progression, acting as either tumor suppressors or oncogenes. | 24609899 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Recent studies have tried to associate colorectal cancer with the aberrant expression of several microRNAs. | 24615484 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are thought to have a role in cancer development. | 24615520 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Epigenetic modifiers such as histone deacetylases (HDACs) have come into focus as novel drug targets for cancer therapy due to their functional role in tumor progression. | 24618845 |
| Carcinoma, Transitional Cell, Renal Cell Carcinoma | Epigenetic Alterations | New miRNA profiles accurately distinguish renal cell carcinomas and upper tract urothelial carcinomas from the normal kidney. | 24621579 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm, Intestinal-Type | Epigenetic Alterations | Elevated expression level of microRNA-196a is predictive of intestinal-type intraductal papillary mucinous neoplasm of the pancreas. | 24622064 |
| Intestinal metaplasia, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-196a (miR-196a) is up-regulated in Barrett esophagus (characterized by intestinal metaplasia) and in colorectal cancer; this relationship between intestinal characteristics and miR-196a might also be applicable to intestinal-type IPMNs. | 24622064 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm, Neoplasms | Epigenetic Alterations | Aberrant expression of several microRNAs (miRs) has been reported in various neoplasms including intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. | 24622064 |
| Mammary Neoplasms | Epigenetic Alterations | The methylation status of the GR promoter was assessed to determine if this observed decrease of expression in breast tumors could be due to epigenetic regulation. | 24622770 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Overexpression of microRNA-155 predicts poor prognosis in glioma patients. | 24623016 |
| Malignant Neoplasms, Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA-155 is highly expressed in many malignant tumors with poor prognosis, which regulates cell apoptosis, proliferation, invasion, metastasis, tumor angiogenesis, and metabolism. | 24623016 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-dependent regulation of transcription in non-small cell lung cancer. | 24625834 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These results suggest miRNA-dependent transcriptional regulation differences play an important role in determining key hallmarks of NSCLC, and may provide new biomarkers for personalized treatment strategies. | 24625834 |
| Adenocarcinoma | Epigenetic Alterations | Nine miRNAs and 56 mRNAs were found to be differentially expressed in SCC versus adenocarcinoma samples. | 24625834 |
| CGN gene, Carcinoma of lung | Epigenetic Alterations | Of them, 6 miRNAs (miR-149, miR-205, miR-375, miR-378, miR-422a and miR-708) and 9 target genes (CEACAM6, CGN, CLDN3, ABCC3, MLPH, ACSL5, TMEM45B, MUC1) were validated by quantitative PCR in an independent cohort of 41 lung cancer patients. | 24625834 |
| Primary malignant neoplasm | Epigenetic Alterations | In an miR-18a overexpressing cell line, the miR-18a concentration of cultured medium increased in both cell number and time-course dependent manners, suggesting microRNA might be released from cancer cells into the surrounding environment. | 24626859 |
| Malignant Neoplasms | Epigenetic Alterations | Recently, circulating microRNAs have been reported to be stably detectable in plasma/serum and to function as potent non-invasive biomarkers in various cancers. | 24626859 |
| Adult T-Cell Lymphoma/Leukemia | Epigenetic Alterations | Overexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells. | 24626955 |
| Hematologic Neoplasms, Neoplasms | Epigenetic Alterations | Microrna-143 (miR-143) has been suggested to be a tumor suppressor, yet its role in hematological tumors has not been determined. | 24626955 |
| Coronary Artery Disease | Epigenetic Alterations | The plasma levels of miR-320b and miR-125b were significantly lower in patients with AMI when compared with controls, and these miRNAs may be involved in the pathogenesis of coronary heart disease. | 24627568 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Peroxisome proliferator-activated receptor g-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer. | 24631504 |
| Carcinogenesis | Epigenetic Alterations | Since PPAR family members are able to modulate complex miRNAs networks, we hypothesized a role of miRNA-145 in the interaction between PPARg and SOX9 in colorectal carcinogenesis. | 24631504 |
| Clinical Coordinator | Epigenetic Alterations | To address this issue, we evaluated gene expression in tissue specimens of CRC patients and we took advantage of invitro models represented by CRC derived cell lines (CaCo2, SW480, HCT116, and HT-29), employing PPARg activation and/or miRNA-145 ectopic overexpression to analyze how their interplay impact the expression of SOX9 and the development of a malignant phenotype. | 24631504 |
| Hollings Cancer Center | Epigenetic Alterations | Taken together, our data suggest that miR-625 might function as an antimetastatic miRNA to have an important role in HCC progression by modulating the IGF2BP1/PTEN pathway. | 24632613 |
| Renal Cell Carcinoma | Epigenetic Alterations | DNA methylation biomarkers predict progression-free and overall survival of metastatic renal cell cancer (mRCC) treated with antiangiogenic therapies. | 24633192 |
| Primary malignant neoplasm | Epigenetic Alterations | Among some cancer patients, epigenetic changes in the nature of methylation of different gene promoter regions are observed, which affect expression of suppressor genes such as septin 9 (SEPT9). | 24633736 |
| Autoimmune Diseases | Epigenetic Alterations | MiRNAs are regulatory molecules that play a key role in the immune system and are altered in many autoimmune diseases. | 24637658 |
| THM gene | Epigenetic Alterations | Our study suggests that different clinical phenotypes in MG share common altered mechanisms in circulating miRNAs, with no additional contribution of the thymoma. | 24637658 |
| Small cell carcinoma of lung | Epigenetic Alterations | A microRNA signature predicts survival in early stage small-cell lung cancer treated with surgery and adjuvant chemotherapy. | 24637927 |
| Small cell carcinoma of lung | Epigenetic Alterations | We found that the miR-150/miR-886-3p signature was significantly correlated with the overall survival (OS) of SCLC patients (p = 0.02) in the training set, and both miRNA expression levels were much lower in the SCLC samples than normal lung samples. | 24637927 |
| Small cell carcinoma of lung | Epigenetic Alterations | First, we surveyed the expression of 924 miRNAs from 42 SCLC patients to discover survival-relevant miRNAs and develop prognostic models, which were then validated in an independent cohort of 40 cases using quantitative real-time PCR. | 24637927 |
| Small cell carcinoma of lung | Epigenetic Alterations | These preliminary results indicated that miRNAs may serve as promising molecular prognostic markers and new therapeutic targets for SCLC. | 24637927 |
| Mycosis Fungoides | Epigenetic Alterations | A specific DNA methylation profile correlates with a high risk of disease progression in stage I classical (Alibert-Bazin type) mycosis fungoides. | 24641245 |
| Metastatic Cervical Squamous Cell Carcinoma, Not Otherwise Specified | Epigenetic Alterations | Characterization of the microRNA expression profile of cervical squamous cell carcinoma metastases. | 24641388 |
| Metastasis | Epigenetic Alterations | MicroRNAs (miRNAs) are important regulators of many physiological and pathological processes, including tumorigenesis and metastasis. | 24641388 |
| cervical cancer | Epigenetic Alterations | MiRNAs having at least 4-fold differential expression between PLN-positive and PLN-negative cervical cancer tissues were bioinformatically analyzed for target gene prediction. | 24641388 |
| Reverse Transcriptase Polymerase Chain Reaction | Epigenetic Alterations | Sixty-nine percent of the miRNAs (27/39) had tumor-associated target genes, and the expression levels of six of those (miR-126, miR-96, miR-144, miR-657, miR-490-5p, and miR-323-3p) were confirmed by quantitative (q)RT-PCR. | 24641388 |
| Metastasis | Epigenetic Alterations | These findings suggest that a panel of miRNAs may regulate multiple and various steps of the metastasis cascade by targeting metastasis-associated genes. | 24641388 |
| cervical cancer | Epigenetic Alterations | Since these six miRNAs are predicted to target tumor-associated genes, it is likely that they contribute to the metastatic potential of cervical cancer and may aid in prognosis or molecular therapy. | 24641388 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-484 is more highly expressed in serum of early breast cancer patients compared to healthy volunteers. | 24641801 |
| Breast Carcinoma | Epigenetic Alterations | These miRNAs are then assessed in serum of breast cancer patients compared to healthy volunteers. | 24641801 |
| Breast Carcinoma | Epigenetic Alterations | Taqman low density array (TLDA) cards were used to profile serum miRNAs in a discovery cohort of serum from 39 early breast cancer patients compared to 10 healthy volunteers. | 24641801 |
| Breast Carcinoma | Epigenetic Alterations | Seventeen miRNAs were found to have significantly higher levels in breast cancer serum compared to serum of healthy volunteers in the discovery cohort. | 24641801 |
| ovarian neoplasm | Epigenetic Alterations | Our previous laboratory and clinical data suggested that one mechanism underlying the development of platinum resistance in ovarian cancer is the acquisition of DNA methylation. | 24642620 |
| Hepatitis B | Epigenetic Alterations | Comparison of circulating, hepatocyte specific messenger RNA and microRNA as biomarkers for chronic hepatitis B and C. Circulating microRNAs have been widely recognized as a novel category of biomarker in a variety of physiological and pathological conditions. | 24643113 |
| Chronic liver disease | Epigenetic Alterations | Taken together, our results suggest that hepatocyte specific transcripts in plasma like albumin mRNA showed greater sensitivity and specificity in differentiating HBV or HCV induced chronic liver disease than microRNA-122. | 24643113 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | Epigenetics are thought to play a major role in the carcinogenesis of multiple sporadic colorectal cancers (CRC). | 24643221 |
| Papillary thyroid carcinoma, F9 gene | Epigenetic Alterations | It has been shown that miRNA 221, 222 and 146b are increasingly expressed while p27(Kip1) is suppressed in papillary thyroid cancer (PTC). | 24643689 |
| Malignant neoplasm of thyroid, Vascular Invasion Assessment, Metastasis | Epigenetic Alterations | Higher expression levels of miRNA 146b, 221 and 222 were detected in thyroid cancer patients presenting with capsule invasion, vascular invasion or lymph node metastasis, when compared to the patients lacking these features. | 24643689 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | The expression levels of miRNA 221, 222 and 146b were found to be increased in cases of thyroid cancer with a high risk of recurrence. | 24643689 |
| Hashimoto Disease, Haiti | Epigenetic Alterations | We also measured the changes in miRNAs in the presence of Hashimotos thyroiditis (HT). | 24643689 |
| Haiti | Epigenetic Alterations | No difference was found between the patients with HT and without HT regarding miRNAs expression levels. | 24643689 |
| ovarian neoplasm | Epigenetic Alterations | Estrogen combined with progesterone decreases cell proliferation and inhibits the expression of Bcl-2 via microRNA let-7a and miR-34b in ovarian cancer cells. | 24643702 |
| Neoplasms | Epigenetic Alterations | Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle. | 24646477 |
| Refractory Cytopenia of Childhood, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Although microRNAs (miRNA) have been revealed as crucial modulators of tumorigenesis, our understanding of their roles in renal cell carcinoma (RCC) is limited. | 24647573 |
| Cell of Claudius | Epigenetic Alterations | We performed microarray-based miRNA profiling of clear cell RCC (ccRCC) and adjacent normal tissues and then explored the roles of miR-141 both in vitro and in vivo, which was the most significantly downregulated in ccRCC tissues. | 24647573 |
| Carcinogenesis | Epigenetic Alterations | Here we sought to identify human miRNAs that act as key regulators of renal carcinogenesis. | 24647573 |
| palladium, Neurodegenerative Disorders, Parkinson Disease | Epigenetic Alterations | Blood-cell-free circulating micro-RNAs (miRNAs) have been proposed as potential accessible biomarkers for neurodegenerative diseases such as Parkinsons disease (PD). | 24648008 |
| Unknown (origin) (qualifier value), Parkinson Disease | Epigenetic Alterations | Identification of blood serum micro-RNAs associated with idiopathic and LRRK2 Parkinsons disease. | 24648008 |
| Biliary stricture | Epigenetic Alterations | MicroRNAs in the bile of patients with biliary strictures after liver transplantation. | 24648209 |
| Diabetes Mellitus, Primary malignant neoplasm | Epigenetic Alterations | RRAD (Ras-related associated with diabetes) is a small Ras-related GTPase that is frequently inactivated by DNA methylation of the CpG island in its promoter region in cancer tissues. | 24648519 |
| Diabetes Mellitus, ovarian neoplasm | Epigenetic Alterations | Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model. | 24648519 |
| ovarian neoplasm | Epigenetic Alterations | Our results indicate that Ras(V12)-mediated oncogenic transformation induces RRAD epigenetic inactivation, which in turn promotes glucose uptake and may contribute to ovarian cancer tumorigenesis. | 24648519 |
| Glioblastoma Multiforme | Epigenetic Alterations | Moreover, these epigenetic alterations overlap those described in glioblastoma patients, suggesting common mechanisms of tumorigenesis. | 24650279 |
| Neoplasms | Epigenetic Alterations | Epigenetic changes are considered to be a frequent event during tumor development. | 24651021 |
| Malignant neoplasm of endometrium, Carcinogenesis | Epigenetic Alterations | The finding suggests the importance of hypermethylation of this gene in endometrial carcinogenesis and could have implications for future diagnostic and therapeutic strategies for endometrial cancer based on epigenetic changes. | 24651021 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Chromatin immunoprecipitation (ChIP) and re-ChIP assays demonstrated marked increases in H3K9me3, H3K27me3, and DNA methylation, together with their respective modifying enzymes G9a, EZH2, and DNA methyltransferases (Dnmts) and respective binding proteins heterochromatin protein 1 (HP1), polycomb protein complex 1 (PRC1) and methyl CpG binding protein 2 (MeCP2), at the COX-2 promoter in lung fibroblasts from patients with IPF (F-IPFs) compared with fibroblasts from nonfibrotic lungs. | 24652950 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Our results support a central role for G9a- and EZH2-mediated histone hypermethylation and a model of bidirectional, mutually reinforcing, and interdependent crosstalk between histone hypermethylation and DNA methylation in COX-2 epigenetic silencing in IPF.-Coward, W. R., Feghali-Bostwick, C. A., Jenkins, G., Knox, A. J., Pang, L. A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis. | 24652950 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis. | 24652950 |
| Primary Neoplasm, Hyperplasia | Epigenetic Alterations | As aberrant CTCFL/BORIS expression might relate to loss of methylation, we explored methylation status in clinical samples from complex atypical hyperplasia, through primary tumors to metastatic lesions, demonstrating a pattern of DNA methylation loss during disease development and progression in line with the increase in CTCFL/BORIS mRNA expression observed. | 24658009 |
| Malignant Neoplasms | Epigenetic Alterations | Cancers arise through accumulating genetic and epigenetic alterations, considered relevant for phenotype and approaches to targeting new therapies. | 24658009 |
| Carcinogenesis | Epigenetic Alterations | It has been demonstrated that aberrant expression of microRNAs (miRNAs) is strongly associated with carcinogenesis. | 24659264 |
| Neoplasms | Epigenetic Alterations | Recently, specific miRNAs may serve as potential biomarkers for the diagnosis and prognosis of various types of tumor. | 24659264 |
| Carcinoma of larynx | Epigenetic Alterations | Epigenetic silencing of the TRAIL receptor by hypermethylation of a DR4 CpG island might be an underlying mechanism for TRAIL resistance in recurrent laryngeal carcinoma treated with radiation. | 24661673 |
| Prostate Cancer Pathway | Epigenetic Alterations | Circulating MicroRNAs in blood of patients with prostate cancer. | 24661838 |
| Pancreatic carcinoma | Epigenetic Alterations | A microRNA-based test improves endoscopic ultrasound-guided cytologic diagnosis of pancreatic cancer. | 24662333 |
| Carcinogenesis | Epigenetic Alterations | An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis. | 24662736 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. | 24663402 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic events play a major role in the carcinogenesis of tobacco-related cancers. | 24664792 |
| Malignant Neoplasms, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Aberrant microRNA (miRNA) expression is involved in tumorigenesis of several cancers, including non-small cell lung cancer (NSCLC). | 24665010 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | However, less is known regarding the role of miRNA methylation in NSCLC development or clinical outcomes. | 24665010 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Therefore, we tested miRNA methylation patterns by quantitative real-time methylation-specific PCR for a panel of candidate miRNAs in 19 NSCLC paired tumor and adjacent normal tissues. | 24665010 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our results demonstrate that miRNA methylation plays a role in NSCLC tumorigenesis and prognosis. | 24665010 |
| Neoplasms | Epigenetic Alterations | Significant differences in methylation patterns were observed for 9 of the 12 miRNAs, all due to hypermethylation in the tumor tissue. | 24665010 |
| Urinary Stress Incontinence | Epigenetic Alterations | Differential expression of microRNAs in periurethral vaginal wall tissues of postmenopausal women with and without stress urinary incontinence. | 24667354 |
| Sui Chinese | Epigenetic Alterations | The expression levels of the three miRNAs were quantified, and a reduction in SUI was revealed. | 24667354 |
| SF3B1 wt Allele, Childhood Leukemia, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling. | 24668493 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | To enhance current models through discovery of novel predictive biomarkers, we employed a genome-wide, agnostic strategy to specifically capture both methylation-directed changes in gene expression and alternative associations of DNA methylation with disease survival in glioma. | 24670968 |
| Primary malignant neoplasm | Epigenetic Alterations | Human GBM-associated DNA methylation, gene expression, IDH1 mutation status, and survival data were obtained from The Cancer Genome Atlas. | 24670968 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Recently, epigenetic alterations were found to play key roles in both glioma genesis and clinical outcome, demonstrating the need to integrate genetic and epigenetic data in predictive models. | 24670968 |
| Neoplasms | Epigenetic Alterations | These results support the existence of cancer-associated DNA methylation profiles in the blood of solid tumor patients that are independent of alterations in normal leukocyte distributions. | 24671036 |
| melanoma | Epigenetic Alterations | The effect of histone modifications and their catalysing enzymes over euchromatic promoter DNA methylation in melanoma remains unclear. | 24673285 |
| melanoma | Epigenetic Alterations | Epigenetic mechanisms participate in melanoma development and progression. | 24673285 |
| Stomach Carcinoma | Epigenetic Alterations | DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach. | 24674026 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | In colorectal cancer, the CpG island methylator phenotype (CIMP) is defined as widespread and elevated levels of DNA methylation and CIMP+ tumors have distinctive clinicopathological and molecular features. | 24674026 |
| Obesity | Epigenetic Alterations | Adaptive expression of microRNA-125a in adipose tissue in response to obesity in mice and men. | 24675842 |
| Obesity | Epigenetic Alterations | Here, we characterized the function of microRNA-125a in adipose tissue in a context of experimentally-induced IR and obesity in mice and in obese patients. | 24675842 |
| Obesity | Epigenetic Alterations | Our findings indicate that microRNA-125a expression in adipose tissue adapts to IR and may play a role in the development of obesity in mice and obese subjects through uncoupled regulation of the expression of microRNA-125a and its targets. | 24675842 |
| Obesity | Epigenetic Alterations | MicroRNAs are emerging as new mediators in the regulation of adipose tissue biology and the development of obesity. | 24675842 |
| Liver carcinoma | Epigenetic Alterations | Single nucleotide polymorphisms of microRNA processing machinery genes and outcome of hepatocellular carcinoma. | 24676133 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) can affect cancer development, treatment efficacy and patients prognosis. | 24676133 |
| Diabetes Mellitus | Epigenetic Alterations | Increasing evidence shows that DNA methylation is involved in the development and progression of diabetes mellitus (DM) and its complications. | 24676352 |
| Kidney Diseases, Diabetes Mellitus | Epigenetic Alterations | DNA methylation is a regulatory mechanism of CTGF expression, which is decreased in patients with DM, particularly in those with DN, and may contribute to the pathogenesis of nephropathy. | 24676352 |
| Carcinoma of supraglottis | Epigenetic Alterations | MicroRNA expression profiles in supraglottic carcinoma. | 24676647 |
| Neoplasms | Epigenetic Alterations | Unsupervised clustering shows that miRNA profiles can distinguish tumor from normal tissues. | 24676647 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are single-stranded RNA molecules which regulate gene expression at the post-transcriptional level and several miRNAs have been found to be associated with some types of cancer. | 24676647 |
| DICER1 protein, human | Epigenetic Alterations | Dicer is a component of the MicroRNA-producing machinery. | 24676997 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Aberrant expression of miRNA (miR)-96 is associated with tumorigenesis and tumor progression in several solid cancers. | 24678958 |
| MYOTONIC DYSTROPHY 1 | Epigenetic Alterations | In conclusion, we identified a characteristic plasma miRNA signature of DM1. | 24679513 |
| Myotonic Dystrophy | Epigenetic Alterations | Plasma microRNAs as biomarkers for myotonic dystrophy type 1. | 24679513 |
| MYOTONIC DYSTROPHY 1 | Epigenetic Alterations | We identified a signature of nine deregulated miRNAs in DM1 patients: eight miRNAs were increased (miR-133a, miR-193b, miR-191, miR-140-3p, miR-454, miR-574, miR-885-5p, miR-886-3p) and one (miR-27b) was decreased. | 24679513 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | Epigenetic processes play a key role in the central nervous system and altered levels of 5-methylcytosine have been associated with a number of neurologic phenotypes, including Alzheimers disease (AD). | 24679604 |
| Malignant neoplasm of esophagus | Epigenetic Alterations | MicroRNA is a class of small, well-conserved, non-coding RNAs, and could play a potential role as diagnostic and prognostic biomarkers of esophageal cancers. | 24680681 |
| Malignant neoplasm of esophagus | Epigenetic Alterations | We aimed to review comprehensively the evidence of microRNA as prognostic biomarkers in esophageal cancers. | 24680681 |
| Esophageal carcinoma | Epigenetic Alterations | Among 33 prognostic microRNAs identified for esophageal cancer, miR-21 and miR-375 appeared more frequently. | 24680681 |
| Esophageal carcinoma | Epigenetic Alterations | These results indicated that microRNAs show promising associations with prognosis in esophageal cancer. | 24680681 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | The microRNAs (miRNAs), namely miR-219-2 and miR-199b, centromeric to the ABL1 gene are frequently lost in CML patients. | 24680705 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | These results provided a novel insight into the mechanism of miRNA regulation in lung adenocarcinoma. | 24682381 |
| Carcinogenesis, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have been recognised to regulate cancer development and progression in carcinogenesis as either oncogenes or tumour suppressor genes. | 24682952 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. | 24686393 |
| Colorectal Cancer Pathway, Adenoma | Epigenetic Alterations | Identification of microRNA-135b in stool as a potential noninvasive biomarker for colorectal cancer and adenoma. | 24691020 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Detecting microRNA (miRNA) in stool is a novel approach for colorectal cancer (CRC) screening. | 24691020 |
| Clinical Coordinator, Adenoma | Epigenetic Alterations | A miRNA expression array covering 667 human miRNAs was performed on five pairs of CRC and two pairs of advanced adenoma tissues. | 24691020 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | microRNAs (miRNA) are promising predictors in colorectal cancer (CRC). | 24691499 |
| Arca, Adenoma | Epigenetic Alterations | The expressions of six candidate miRNAs were significantly decreased from levels in normal colorectal tissue compared with ARCA with adenoma recurrence (RACRA) in this retrospective cohort. | 24691499 |
| Bladder Neoplasm | Epigenetic Alterations | Changes in DNA methylation are chemically stable, occur early during tumorigenesis, and can be quantified in bladder tumors and in cells shed into the urine. | 24691641 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | We analyzed the DNA methylation levels of six markers in 368 urine sediment samples serially collected from 90 patients with noninvasive urothelial carcinoma (Tis, Ta, T1; grade low-high). | 24691641 |
| Neoplasms | Epigenetic Alterations | The three-marker DNA methylation test reliably predicted tumor recurrence in 80% of patients superior to cytology (35%) and cystoscopy (15%) while accurately forecasting no recurrence in 74% of patients that scored negative in the test. | 24691641 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | MicroRNA-203 inhibits the progression of esophageal squamous cell carcinoma with restored epithelial tissue architecture in vivo. | 24692008 |
| SERPINB3 wt Allele | Epigenetic Alterations | Thirteen miRNAs, including miRNA-155, were upregulated (>2-fold) in OSCC against ACF. | 24692283 |
| SERPINB3 wt Allele, Primary malignant neoplasm | Epigenetic Alterations | MiRNA-155 was confirmed to have significantly higher expression in OSCC against ACF (paired-samples t test; p = .041) and it was localized in the cancer nest, inflammatory area, and vascular endothelium of OSCC. | 24692283 |
| SERPINB3 wt Allele | Epigenetic Alterations | High expression of miRNA-155 in ACF tissue was an independent prognostic indicator for OSCC survival. | 24692283 |
| SERPINB3 wt Allele, Primary malignant neoplasm | Epigenetic Alterations | MiRNA-155 was overexpressed in OSCC and it was located in the cancer nest, inflammatory area, and vascular endothelium of OSCC. | 24692283 |
| SERPINB3 wt Allele | Epigenetic Alterations | High miRNA-155 expression level in ACF may predict poor prognosis in patients with OSCC. | 24692283 |
| SERPINB3 wt Allele, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) play an important role in cancer, but their role in OSCC is not clarified. | 24692283 |
| Neoplasms | Epigenetic Alterations | No association between miRNA expression and tumor grade, tumor size, menopausal- or lymph node status was observed. | 24694649 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are present in the circulation and may be unique biomarkers for early diagnosis of human cancers. | 24694649 |
| Breast Carcinoma | Epigenetic Alterations | Since microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer. | 24694649 |
| Breast Carcinoma | Epigenetic Alterations | A signature of miRNAs was subsequently validated in an independent set of 111 serum samples from 60 patients with early-stage breast cancer and 51 healthy controls and further tested for reproducibility in 3 independent data sets from the GEO Database. | 24694649 |
| Breast Carcinoma | Epigenetic Alterations | A multivariable signature consisting of 9 miRNAs (miR-15a, miR-18a, miR-107, miR-133a, miR-139-5p, miR-143, miR-145, miR-365, miR-425) was identified that provided considerable discrimination between breast cancer patients and healthy controls. | 24694649 |
| Breast Carcinoma | Epigenetic Alterations | The signature was also successfully validated in a previously published independent data set of circulating miRNAs in early-stage breast cancer (p = 0.024). | 24694649 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic modifications are important early events during carcinogenesis. | 24695110 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | To conclude, our findings demonstrated that epigenetic dysregulation of TFPI-2, leading to its reduced expression, is frequently detected in canine DLBCL. | 24695110 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNA-25 expression level is an independent prognostic factor in epithelial ovarian cancer. | 24696291 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Different expression of miRNAs in early esophageal squamous cell carcinoma with differential prognosis. | 24697845 |
| Metastasis | Epigenetic Alterations | Such miRNAs were associated with lympho-vascular invasion and metastasis, and acted as predictive markers of lympho-vascular invasion and metastasis. | 24697845 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The detection of these miRNAs forms an important basis for the treatment of early ESCC. | 24697845 |
| Virus Diseases | Epigenetic Alterations | Our findings unravel the significant alterations in serum miRNA expression following virus infection and manifest great potential of circulating miRNAs for the diagnosis of viral diseases. | 24699363 |
| Communicable Diseases | Epigenetic Alterations | Upon infection, a total of 395 miRNAs were expressed in the serum pool of patients, far beyond the 221 in healthy controls. | 24699363 |
| Stomach Carcinoma | Epigenetic Alterations | Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer. | 24700496 |
| Carcinoma in situ of skin | Epigenetic Alterations | Epigenetic alterations in metastatic cutaneous carcinoma. | 24700717 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic profiles of 37 primary cases of cutaneous SCC and BCC were quantified via the Illumina Goldengate Cancer Panel. | 24700717 |
| Skin carcinoma | Epigenetic Alterations | Epigenetic profiling may prove useful in future diagnosis and prevention of advanced nonmelanoma skin cancers. | 24700717 |
| Primary malignant neoplasm | Epigenetic Alterations | Micro-RNAs (miRNAs) are small noncoding RNAs that play a crucial role in regulating gene expression and are involved in various biological processes, including cancer development. | 24703100 |
| Malignant neoplasm of kidney | Epigenetic Alterations | In summary, we describe the miRNA expression profile of a relatively infrequent type of renal cancer. | 24703100 |
| Clear cell papillary renal cell carcinoma, Conventional (Clear Cell) Renal Cell Carcinoma, Papillary Renal Cell Carcinoma | Epigenetic Alterations | Clear cell papillary renal cell carcinoma: micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. | 24703100 |
| Aggressive behavior | Epigenetic Alterations | Moreover, CCPRCC lacks dysregulation of important miRNAs typically associated with aggressive behavior. | 24703100 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNA let-7a-3 gene methylation is associated with karyotyping, CEBPA promoter methylation, and survival in acute myeloid leukemia. | 24703161 |
| Primary malignant neoplasm | Epigenetic Alterations | Let-7a-3 transcribes the miRNA let-7a, of which the expression is dysregulated in cancer. | 24703161 |
| Hollings Cancer Center | Epigenetic Alterations | In summary, our results suggest that DNA methylation may be involved in the inactivation of miR-34b in HCC. | 24704024 |
| Liver carcinoma | Epigenetic Alterations | Methylation-associated silencing of microRNA-34b in hepatocellular carcinoma cancer. | 24704024 |
| Malignant Neoplasms, Hollings Cancer Center | Epigenetic Alterations | MicroRNAs (miRNAs) can act as oncogenes or tumor-suppressor genes in human cancers including HCC. | 24704024 |
| Clinical Coordinator | Epigenetic Alterations | Exosomal miRNA signatures appear to mirror pathological changes of CRC patients and several miRNAs are promising biomarkers for non-invasive diagnosis of the disease. | 24705249 |
| Malignant tumor of colon | Epigenetic Alterations | Circulating exosomal microRNAs as biomarkers of colon cancer. | 24705249 |
| Primary malignant neoplasm | Epigenetic Alterations | Exosomal microRNAs (miRNAs) have been attracting major interest as potential diagnostic biomarkers of cancer. | 24705249 |
| Malignant tumor of colon | Epigenetic Alterations | The expression levels of miRNAs in the culture medium of five colon cancer cell lines were also compared with those in the culture medium of a normal colon-derived cell line. | 24705249 |
| Neoplasms, disease stage | Epigenetic Alterations | The serum exosomal levels of seven miRNAs (let-7a, miR-1229, miR-1246, miR-150, miR-21, miR-223, and miR-23a) were significantly higher in primary CRC patients, even those with early stage disease, than in healthy controls, and were significantly down-regulated after surgical resection of tumors. | 24705249 |
| Malignant tumor of colon | Epigenetic Alterations | These miRNAs were also secreted at significantly higher levels by colon cancer cell lines than by a normal colon-derived cell line. | 24705249 |
| Prostate Cancer Pathway | Epigenetic Alterations | This highlights the need for independent validation patient cohorts and suggests that urinary microRNA signatures at radical prostatectomy may not be a robust way to predict the course of clinical disease after definitive treatment for prostate cancer. | 24705338 |
| Prostate Cancer Pathway | Epigenetic Alterations | Curated microRNAs in urine and blood fail to validate as predictive biomarkers for high-risk prostate cancer. | 24705338 |
| Prostate Cancer Pathway | Epigenetic Alterations | Our initial findings suggested that plasma and urinary profiling of microRNAs at radical prostatectomy may allow prognostication of prostate cancer behaviour. | 24705338 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Long non-coding RNA 91H contributes to the occurrence and progression of esophageal squamous cell carcinoma by inhibiting IGF2 expression. | 24706416 |
| Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Hypermethylation of DNA is an epigenetic alteration commonly found in colorectal cancer (CRC) and can also be detected in blood samples of cancer patients. | 24708595 |
| Ischemic stroke | Epigenetic Alterations | The relationship between circulating microRNA-223 and pathogenesis of acute ischemic stroke is unknown. | 24708646 |
| Infarction, TOAST Classification | Epigenetic Alterations | The relationship between the microRNA-223 level and NIHSS scores, TOAST subtypes, and infarct volume was analyzed respectively. | 24708646 |
| Ischemic stroke | Epigenetic Alterations | microRNA-223 levels in the circulating blood of acute ischemic stroke patients were greatly increased compared to the control (p < 0.05). | 24708646 |
| Cerebrovascular accident, Infarction | Epigenetic Alterations | microRNA-223, which were negatively correlated with NIHSS scores (r = -0.531, p < 0.01) and infarct volume (r = -0.265, p = 0.039), was significantly up-regulated in large artery and small artery strokes. | 24708646 |
| Cerebral artery occlusion | Epigenetic Alterations | Moreover, microRNA-223 in blood and brain were positively correlated (r = 0.834, p < 0.05), and they were up-regulated significantly in mice that underwent middle cerebral artery occlusion (p < 0.05). | 24708646 |
| Cerebrovascular accident, Ischemic stroke | Epigenetic Alterations | Our results suggest that microRNA-223 is associated with acute ischemic stroke and possibly plays a role in stroke through up-regulating growth factor such as insulin-like growth factor-1 gene. | 24708646 |
| Arthritis, Gouty | Epigenetic Alterations | MicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis. | 24708712 |
| Disease | Epigenetic Alterations | Their data, collected from June 22, 2011 to September 28, 2012, in a comprehensive epidemiological survey and during medical examinations, permitted an extensive evaluation of the relation between metal exposure, gene, epigenetics and risk of human diseases. | 24709102 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Identification of a circulating microRNA signature for colorectal cancer detection. | 24709885 |
| Clinical Coordinator | Epigenetic Alterations | We built a serum microRNA expression profile signature and tested its specificity and sensitivity as a biomarker in the diagnosis of CRC. | 24709885 |
| Clinical Coordinator | Epigenetic Alterations | Thus, the identified six-miRNA signature can be used as a noninvasive biomarker for the diagnosis of CRC, with relatively high sensitivity and specificity. | 24709885 |
| Neoplasms | Epigenetic Alterations | The discovery of microRNAs (miRNAs) and their different expression profiles among different kinds of diseases has opened a new avenue for tumor diagnosis. | 24709885 |
| Clinical Coordinator | Epigenetic Alterations | We conducted a two phase case-control test to identify serum miRNAs as biomarkers for CRC diagnosis. | 24709885 |
| Clinical Coordinator | Epigenetic Alterations | The expression levels of the six serum miRNAs were also correlated with CRC progression. | 24709885 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Frequency of genetic and epigenetic alterations of p14ARF and p16INK4A in head and neck cancer in a Hungarian population. | 24710824 |
| cervical cancer | Epigenetic Alterations | MicroRNA-215 is a potential prognostic marker for cervical cancer. | 24710934 |
| Malignant Neoplasms, Metastasis, Neoplasms | Epigenetic Alterations | Recently, microRNAs (miRNAs) have been shown to be involved in multiple biological pathways that can influence tumor progression and metastasis and they can serve as prognostic biomarkers in many cancers. | 24710934 |
| Hormone refractory prostate cancer | Epigenetic Alterations | Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer. | 24714754 |
| Prostate Cancer Pathway, Aggressive behavior | Epigenetic Alterations | DNA promoter hypermethylation is a frequent epigenetic event in prostate cancer, but few studies of DNA methylation in relation to features of more aggressive tumors or prostate cancer recurrence have been completed. | 24718283 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | We used the Infinium HumanMethylation450 BeadChip to assess DNA methylation in tumor tissue from 407 patients with clinically localized prostate cancer who underwent radical prostatectomy. | 24718283 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Tumor DNA methylation profiling may help to distinguish patients with prostate cancer at higher risk for disease recurrence. | 24718283 |
| Metastasis, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation and histone H3-K9 trimethylation of EFEMP1 may be responsible for its downregulation in GC, and thus have an important role in tumor invasion and metastasis. | 24718752 |
| palladium, Parkinson Disease | Epigenetic Alterations | DNA methylation of a CpG island located in intron 1 of the a-synuclein gene (SNCA) has been reported to play an essential role in the regulation of a-synuclein transcription, and probably has a close association with Parkinsons disease (PD). | 24721670 |
| palladium | Epigenetic Alterations | Our results indicated that there were no significant differences in DNA methylation between PD patients and controls. | 24721670 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Thus, the TP53/MIR34A "double hit" characterizes a very aggressive subgroup of DLBCL, which may be treatable with epigenetic therapy prior to or in combination with conventional immunochemotherapy. | 24722400 |
| Neoplasms | Epigenetic Alterations | Accumulating evidence is revealing an important role of microRNA (miRNA) in tumor progression and chemotherapeutic resistance. | 24723223 |
| DICER1 protein, human | Epigenetic Alterations | Dicer is a cytoplasmic endoribonuclease type III crucial for production of mature miRNAs. | 24723223 |
| Lichen disease | Epigenetic Alterations | Global DNA methylation: uncommon event in oral lichenoid disease. | 24724918 |
| Squamous cell carcinoma, Carcinogenesis | Epigenetic Alterations | Accumulating evidence indicates that aberrant DNA methylation is closely related to oral carcinogenesis, and it has been shown that methylation changes might be used as prognostic biomarker in oral squamous cell carcinoma. | 24724918 |
| Malignant tumor of colon | Epigenetic Alterations | Association study of the let-7 miRNA-complementary site variant in the 3 untranslated region of the KRAS gene in stage III colon cancer (NCCTG N0147 Clinical Trial). | 24727325 |
| Angina, Unstable | Epigenetic Alterations | Assessment of microRNAs in patients with unstable angina pectoris. | 24727883 |
| Glioma, Neoplasms | Epigenetic Alterations | Differential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours. | 24729345 |
| Hypoxia, Neoplasms | Epigenetic Alterations | The microRNA, miR-210, is frequently associated with hypoxia induction, and an increase in its levels is often correlated with poor prognosis in many solid tumours. | 24729345 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905. | 24732316 |
| Neoplasms | Epigenetic Alterations | In conclusion, the frequent heterozygous losses of the RB1 locus could partly explain the decreased RB expression in MCV-negative MCC tumors, although the effects of RB1 mutations, coinciding promoter hypermethylation and, for example, miRNA regulation, cannot be excluded. | 24735260 |
| Neoplasms | Epigenetic Alterations | Expression of CYP24A1 was inversely correlated with promoter DNA methylation in lung AC cell lines and tumors. | 24736069 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma. | 24736069 |
| Carcinogenesis | Epigenetic Alterations | DNA methylation status of a distinctively different subset of genes is associated with each histologic Lauren classification subtype in early gastric carcinogenesis. | 24737029 |
| Carcinogenesis | Epigenetic Alterations | DNA methylation change is known to play a crucial role in early gastric carcinogenesis. | 24737029 |
| Stomach Carcinoma | Epigenetic Alterations | Aberrant histone methylation and the effect of Suv39H1 siRNA on gastric carcinoma. | 24737085 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | We developed cMethDNA, a quantitative multiplexed methylation-specific PCR assay for a panel of ten genes, consisting of novel and known breast cancer hypermethylated markers identified by mining our previously reported study of DNA methylation patterns in breast tissue (103 cancer, 21 normal on the Illumina HumanMethylation27 Beadchip) and then validating the 10-gene panel in The Cancer Genome Atlas project breast cancer methylome database. | 24737128 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidence indicates that dysregulated microRNAs (miRNAs) are involved in cancer development, progression and metastasis. | 24737193 |
| Malignant tumor of colon | Epigenetic Alterations | Expression levels of SELENBP1, carcinoembryonic antigen (CEA) and alkaline phosphatase (AKP) were determined in cultures of human colon cancer cell lines (SW480, SW620 and HT29) folllowing treatment with i) sodium butyrate (NaB, 2 mM), a differentiation inducer; ii) Trichostatin A (TSA, 0.3 uM), a histone deacetylase inhibitor; or iii) 5-aza-2-deoxycytidine (5-Aza-dC, 5 uM), a DNA methylation inhibitor. | 24737289 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Selenium-binding protein 1 is associated with the degree of colorectal cancer differentiation and is regulated by histone modification. | 24737289 |
| Stomach Carcinoma | Epigenetic Alterations | Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer. | 24737431 |
| Prostate Cancer Pathway | Epigenetic Alterations | The GABRE~miR-452~miR-224 locus is downregulated and hypermethylated in prostate cancer and is a new promising epigenetic candidate biomarker for prostate cancer diagnosis and prognosis. | 24737792 |
| Prostate Cancer Pathway | Epigenetic Alterations | Tumor-suppressive functions of the intronic miR-224 and miR-452 were demonstrated in two prostate cancer cell lines, suggesting that epigenetic silencing of GABRE~miR-452~miR-224 may be selected for in prostate cancer. | 24737792 |
| Dermatitis, Atopic | Epigenetic Alterations | An integrated epigenetic and transcriptomic analysis reveals distinct tissue-specific patterns of DNA methylation associated with atopic dermatitis. | 24739813 |
| Admitting diagnosis | Epigenetic Alterations | No genome-wide significant DNA methylation differences between AD cases and controls were observed in whole blood, T cells, and B cells, and, in general, intra-individual differences in DNA methylation were larger than interindividual differences. | 24739813 |
| Admitting diagnosis | Epigenetic Alterations | Our pilot study provides preliminary evidence for functionally relevant DNA methylation differences associated with AD, particularly in the epidermis, and represents a starting point for future investigations of epigenetic mechanisms in AD. | 24739813 |
| Prostate Cancer Pathway | Epigenetic Alterations | Recent evidence indicates that microRNAs might participate in prostate cancer initiation, progression and treatment response. | 24740842 |
| Prostate Cancer Pathway | Epigenetic Alterations | Germline variations in microRNAs might alter target gene expression and modify the efficacy of prostate cancer therapy. | 24740842 |
| palladium | Epigenetic Alterations | Increased expression of alpha-synuclein (PARK4) is a disease-triggering event in familial PD and also observed in SN DA neurons in sporadic PD but related transcriptional changes are unknown. | 24742361 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | To this end, we performed a miRNA profiling of 1547 distinct human miRNAs using 31 samples of tumor and paired normal mucosa obtained from 31 CRC patients. | 24743265 |
| Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Aberrant expression of microRNAs (miRNAs) has been implicated in human cancer, including colorectal cancer (CRC). | 24743265 |
| Clinical Coordinator | Epigenetic Alterations | However, the nature of an association between these miRNAs and clinical stages of CRC is still not clear. | 24743265 |
| Colorectal Carcinoma | Epigenetic Alterations | Among the 569 dysregulated miRNAs, downregulation of 17 was associated with stages II, III, and IV colon and rectal cancers (separate or combined), according to our criteria. | 24743265 |
| Clinical Coordinator, Metastasis | Epigenetic Alterations | We also assessed the potential of these dysregulated miRNAs as diagnostic biomarkers for CRC patients who were without metastasis, and the value of the dysregulated miRNAs for predicting metastasis, lymph node and distant. | 24743265 |
| Chronic Obstructive Airway Disease, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | MicroRNA clusters: dysregulation in lung adenocarcinoma and COPD. | 24743967 |
| Chronic Obstructive Airway Disease, Adenocarcinoma | Epigenetic Alterations | Expression of 381 miRNAs was quantified by TaqMan Human MicroRNA A Array v2.0 in bronchoalveolar lavage fluid samples from 87 patients classified into four groups: COPD, adenocarcinoma, adenocarcinoma with COPD, and control (neither COPD nor adenocarcinoma). | 24743967 |
| Chronic Obstructive Airway Disease, Adenocarcinoma | Epigenetic Alterations | Four miRNA clusters (the mir-17-92 cluster and its paralogues, mir-106a-363 and mir-106b-25; and the miR-192-194 cluster) were upregulated in patients with adenocarcinoma and one miRNA cluster (miR-132-212) was upregulated in patients with COPD. | 24743967 |
| Chronic Obstructive Airway Disease, Adenocarcinoma | Epigenetic Alterations | These results contribute to unravelling miRNA-controlled networks involved in the pathogenesis of adenocarcinoma and COPD, and provide new tools of potential use as biomarkers for diagnosis and/or therapeutic purposes. | 24743967 |
| Coronary Artery Disease | Epigenetic Alterations | Association of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary artery disease patients. | 24745016 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are closely involved in the development and progression of various tumors. | 24745613 |
| Intrahepatic Cholangiocarcinoma | Epigenetic Alterations | IMP3 expression is associated with poor outcome and epigenetic deregulation in intrahepatic cholangiocarcinoma. | 24745619 |
| Breast Cancer Cell | Epigenetic Alterations | To our knoweldge, this is the first direct evidence of epigenetic deregulation of IMP3 in human cancer. | 24745619 |
| Myometrial Invasion, Endometrial Endometrioid Adenocarcinoma, Primary malignant neoplasm | Epigenetic Alterations | Micro-RNA (miRNA) signatures influence the prognosis of cancer, but little is known about their role in myometrial invasion in endometrioid endometrial adenocarcinoma (EEC). | 24746199 |
| Adenocarcinoma in Situ, Adenocarcinoma | Epigenetic Alterations | Of the 20 miRNAs differentially expressed in noninvasive (stage IA) and myoinvasive adenocarcinomas (stage IB and IC), miR27 was overexpressed in invasive adenocarcinomas, and its expression increased linearly according to stage. | 24746199 |
| cervical cancer | Epigenetic Alterations | Overexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer. | 24748337 |
| Malignant Neoplasms | Epigenetic Alterations | The long noncoding RNA HOTAIR has been reported to be a good biomarker for poor prognosis in a variety of human cancers. | 24748337 |
| Stomach Carcinoma | Epigenetic Alterations | This study explores the possibility of methylation of DNA damage repair genes serving as a prognostic and chemo-sensitive marker in human gastric cancer. | 24748501 |
| Clinical Coordinator | Epigenetic Alterations | We provide the first evidence that variations in potential miRNA target-binding sites in the 3UTR of MMR genes may contribute to modulate CRC prognosis and predictivity of therapy. | 24755277 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1. | 24755295 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer tissues from patients with or without liver metastases were profiled to identify differentially expressed microRNA. | 24755295 |
| Neoplasms | Epigenetic Alterations | Thus, genetic alterations of b-catenin and epigenetics-related Wif-1 promoter hypermethylation may be important mechanisms underlying AC tumor formation though aberrant canonical Wnt/b-catenin signaling activation. | 24755523 |
| Tumors of Adrenal Cortex | Epigenetic Alterations | Extracellular activation of Wnt signaling through epigenetic dysregulation of Wnt inhibitory factor-1 (Wif-1) is associated with pathogenesis of adrenocortical tumor. | 24755523 |
| Neoplasms | Epigenetic Alterations | We investigated epigenetic regulation of Wif-1 and its association with adrenocortical (AC) tumor pathogenesis in light of Wnt activation. | 24755523 |
| Neoplasms | Epigenetic Alterations | Dysregulation of microRNAs (miRNAs) expression is an important step in tumor progression as miRNAs can act as tumor suppressors or oncogenes and may affect cell sensitivity to chemotherapy. | 24755707 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | A detailed understanding of the mechanisms of microRNA that are clinically relevant in AML may enhance our ability to predict and overcome drug resistance. | 24756163 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNAs have been shown to play an important role in regulating the chemotherapy resistance in AML. | 24756163 |
| Breast Carcinoma | Epigenetic Alterations | Aberrant DNA methylation of integrin a4 in human breast cancer. | 24756760 |
| Ductal Carcinoma | Epigenetic Alterations | In addition, DNA methylation of integrin a4 showed statistical correlation with HER2 positivity and higher histologic grade (p = 0.001, 0.008 in ductal carcinoma in situ and 0.003 in invasive ductal carcinoma). | 24756760 |
| Breast Carcinoma | Epigenetic Alterations | Moreover, we found that the downregulated expression of integrin a4 in a heavily methylated breast cancer cell line (ZR-75) was restored by treatment with 5-aza-2deoxycytidine, a DNA methyltransferase inhibitor, implying transcriptional silencing by DNA methylation. | 24756760 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation of integrin a4 may be a poor prognostic factor which affects undifferentiated histologic change of breast cancer. | 24756760 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | These results suggest that these three variants in the miRNA binding sites of TYMS may be associated with cancer risk and survival of gastric cancer patients. | 24756984 |
| Degenerative polyarthritis | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) play crucial regulatory roles in diverse biologic processes, but knowledge of lncRNAs in osteoarthritis (OA) is limited. | 24757148 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | Our group recently identified specific histone modifications occurring during apoptosis that play an important role in the autoimmune response in SLE. | 24758196 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | This implies that specific histone modifications, in particular acetylation, might enhance the immunostimulatory potential of NETs in SLE. | 24758196 |
| Hepatocellular carcinoma, scirrhous | Epigenetic Alterations | Correlation of microRNA-16, microRNA-21 and microRNA-101 expression with cyclooxygenase-2 expression and angiogenic factors in cirrhotic and noncirrhotic human hepatocellular carcinoma. | 24759835 |
| Hormone refractory prostate cancer | Epigenetic Alterations | Our purpose was to identify a miRNA expression profile associated with the development of CRPC. | 24760272 |
| Aggressive behavior, Primary malignant neoplasm | Epigenetic Alterations | The increased evidence that miRNAs are involved in cancer development and progression has made them potential biomarkers for cancer diagnosis, prognosis, and aggressiveness. | 24760272 |
| Chordoma | Epigenetic Alterations | MicroRNA-1 (miR-1) inhibits chordoma cell migration and invasion by targeting slug. | 24760686 |
| cervical cancer | Epigenetic Alterations | Epigenetic regulation of human riboflavin transporter 2(hRFT2) in cervical cancers from Uighur women. | 24761851 |
| Carcinogenesis | Epigenetic Alterations | Our results suggested that epigenetic modifications are responsible for aberrant expression of the hRFT2 gene, and may help to understand mechanisms of cervical carcinogenesis. | 24761851 |
| ovarian neoplasm | Epigenetic Alterations | DNA was extracted from 200 formalin-fixed paraffin-embedded ovarian cancer and their normal adjacent tissues (NAT) and DNA methylation was detected by methylation specific PCR (MSP). | 24761891 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | This finding highlights the possible role of the high risk HPV virus in ovarian carcinogenesis or in facilitating cancer progression by suppression of SFRP and APC genes via DNA methylation. | 24761891 |
| melanoma | Epigenetic Alterations | We observed that CDKN2A epimutation is rare in melanoma families, and therefore is unlikely to cause major susceptibility in families without CDKN2A mutations. | 24762620 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain. | 24763054 |
| Pathology | Epigenetic Alterations | Comparing the top miRNAs with the highest levels detected in each pool, we found close homology only between the BAL samples of the two pathologies. | 24764226 |
| Neoplasms | Epigenetic Alterations | In tumor plasma, we found a higher percentage of miRNAs with increased levels than in tumor BAL or in nontumor plasma. | 24764226 |
| Adenoma | Epigenetic Alterations | BRBs significantly decreased cellular proliferation, DNA methylation methyl transferase 1 protein expression, and p16 promoter methylation, but not promoter methylation of the Wnt pathway antagonists, SFRP2 and WIF1, in rectal polyps (adenomas) from responders but not from nonresponders. | 24764585 |
| Prostate Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer. | 24768995 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our recent study of the microRNA expression signature of prostate cancer (PCa) revealed that microRNA-224 (miR-224) is significantly downregulated in PCa tissues. | 24768995 |
| Malignant Neoplasms | Epigenetic Alterations | The single nucleotide polymorphisms (SNPs) involved in microRNA (miRNA) functions are potential biomarkers for prognosis of various human cancers. | 24770678 |
| levamisole | Epigenetic Alterations | Initially, 10 high-grade LMS and 10 high-grade UPS were profiled with a miRNA microarray. | 24771630 |
| levamisole, Neoplasms | Epigenetic Alterations | We identified miRNA expression patterns in LMS and UPS, linking them to chromosomal regions and mRNA targets known to be involved in tumor development/progression of LMS and UPS. | 24771630 |
| Colorectal Cancer Pathway | Epigenetic Alterations | To identify microRNAs (miRNA) that predict response to anti-EGFR antibodies in patients with wild-type KRAS metastatic colorectal cancer (mCRC). | 24771647 |
| Islet Cell Tumor | Epigenetic Alterations | Global microRNA profiling of pancreatic neuroendocrine neoplasias. | 24778027 |
| Colorectal Cancer Pathway, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Furthermore, microRNA profiles of primary colorectal cancer in our database indicated that these two microRNAs were overexpressed in primary colorectal cancer relative to primary lung adenocarcinomas. | 24778034 |
| Carcinoma of lung, Secondary malignant neoplasm of rectum, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | MicroRNA profiles predict the histology of primary lung carcinomas, and differentiate between primary lung adenocarcinomas and colorectal cancer metastases. | 24778034 |
| Malignant neoplasm of endometrium, Neoplasms | Epigenetic Alterations | microRNA 31 functions as an endometrial cancer oncogene by suppressing Hippo tumor suppressor pathway. | 24779718 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNAs play essential role in breast carcinoma progression and invasion. | 24781337 |
| Pituitary macroadenoma, Neoplasms | Epigenetic Alterations | A pilot genome-scale profiling of DNA methylation in sporadic pituitary macroadenomas: association with tumor invasion and histopathological subtype. | 24781529 |
| Oropharyngeal Carcinoma, Neoplasms | Epigenetic Alterations | Prognostic factors in oral and oropharyngeal cancer based on ultrastructural analysis and DNA methylation of the tumor and surgical margin. | 24782031 |
| Osteosarcoma | Epigenetic Alterations | Prognostic value of microRNA-223/epithelial cell transforming sequence 2 signaling in patients with osteosarcoma. | 24784921 |
| Osteosarcoma | Epigenetic Alterations | MicroRNA-223 (miR-223) has been demonstrated to be implicated in cell proliferation and cell cycle progression of osteosarcoma cell lines by regulating its target gene epithelial cell transforming sequence 2 (ECT2). | 24784921 |
| Primary malignant neoplasm | Epigenetic Alterations | Altered expression of microRNA (miRNA) can significantly contribute to cancer development and recent studies have shown that a number of miRNAs may be regulated by DNA methylation. | 24785261 |
| Stomach Carcinoma, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Our study provides unequivocal evidence that MIR941 and MIR1247 are transcriptionally regulated by DNA methylation in gastric cancer and that they have tumor suppressor properties through their inhibition of key cancer promoting genes in this context. | 24785261 |
| Malignant neoplasm of stomach | Epigenetic Alterations | We confirmed that these miRNAs are also densely methylated in primary gastric cancers but not in normal gastric tissues. | 24785261 |
| Stomach Carcinoma | Epigenetic Alterations | In addition, we demonstrated that ectopic expression of these two miRNAs in AGS gastric cancer cells resulted in suppression of growth and migration. | 24785261 |
| Spondylitis | Epigenetic Alterations | Higher expression of whole blood microRNA-21 in patients with ankylosing spondylitis associated with programmed cell death 4 mRNA expression and collagen cross-linked C-telopeptide concentration. | 24786924 |
| Cessation of life | Epigenetic Alterations | The binding of microRNA-21 (miR-21) to programmed cell death 4 (PDCD4) could inhibit the expression of PDCD4 and further induce the activation of osteoclasts. | 24786924 |
| Ischemic stroke | Epigenetic Alterations | Global DNA methylation of ischemic stroke subtypes. | 24788121 |
| Cerebrovascular accident, Pathology, Cardiovascular Diseases | Epigenetic Alterations | Epigenetic mechanisms, such as DNA methylation, change over time and may be associated with aging processes and with modulation of the risk of various pathologies, such as cardiovascular disease and stroke. | 24788121 |
| Adenoma | Epigenetic Alterations | Differential expression of microRNA-320a, -145, and -192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum. | 24791633 |
| Carcinogenesis, Metastasis | Epigenetic Alterations | MicroRNA (miR)-320a, miR-145, and miR-192 have been shown to play a role in colorectal carcinogenesis and metastasis. | 24791633 |
| Colonic adenomas | Epigenetic Alterations | Genome-wide miRNA expression profiling was performed on 113 colon adenomas. | 24791633 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Long non-coding RNA MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion. | 24793017 |
| Malignant Neoplasms | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have emerged as major players in governing fundamental biological processes, and many of which are misregulated in multiple cancers and likely to play a functional role in tumorigenesis. | 24793017 |
| Colorectal Cancer Pathway, Adenoma | Epigenetic Alterations | Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. | 24793120 |
| Malignant Neoplasms | Epigenetic Alterations | We found genome-wide alterations in DNA methylation in the nontumor colon mucosa and cancers. | 24793120 |
| Malignant Neoplasms, Adenoma | Epigenetic Alterations | Three classes of cancers and 2 classes of adenomas were identified based on their DNA methylation patterns. | 24793120 |
| Malignant Neoplasms, Colonic Neoplasms, Adenoma | Epigenetic Alterations | Additionally, the high-frequency methylation adenoma class had DNA methylation signatures similar to those of cancers with low or intermediate levels of methylation, and the low-frequency methylation adenoma class had methylation signatures similar to that of nontumor colon tissue. | 24793120 |
| Tubular adenoma, Primary malignant neoplasm | Epigenetic Alterations | Genome-wide alterations in DNA methylation occur during early stages of progression of tubular adenomas to cancer. | 24793120 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Genetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC). | 24793120 |
| Clinical Coordinator, Tubular adenoma | Epigenetic Alterations | Although epigenetic and genetic alterations have been detected in conventional tubular adenomas, little is known about how these affect progression to CRC. | 24793120 |
| Colorectal Carcinoma, Tubular adenoma, Primary malignant neoplasm | Epigenetic Alterations | We compared methylomes of normal colon mucosa, tubular adenomas, and colorectal cancers to determine how epigenetic alterations might contribute to cancer formation. | 24793120 |
| Neoplasms | Epigenetic Alterations | In ccRCC, microRNAs (miRs) differentially expressed in tumour tissue have been identified and have been proposed to predict prognosis. | 24793999 |
| Breast Carcinoma, Discordance | Epigenetic Alterations | The discordance of ER expression status in primary and relapse/metastatic lesions of breast cancer might be related to DNA methylation status. | 24796462 |
| Carcinoma, Squamous cell carcinoma of esophagus | Epigenetic Alterations | F-box protein 32 (FBXO32) (also known as atrogin-1), a member of the F-box protein family, has recently been identified as a transforming growth factor beta (TGF-b)/Smad target gene involved in regulating cell survival, and it may be transcriptionally silenced by epigenetic mechanisms in some kinds of carcinomas, yet its role in esophageal squamous cell carcinoma (ESCC) has not been defined. | 24798237 |
| Colorectal Neoplasms | Epigenetic Alterations | CAHM, a long non-coding RNA gene hypermethylated in colorectal neoplasia. | 24799664 |
| Secondary malignant neoplasm of lung, Malignant neoplasm of liver, Primary malignant neoplasm | Epigenetic Alterations | Efficacy and potential microRNA mechanism for computed tomography-guided percutaneous radiofrequency ablation of primary lung cancer and lung metastasis from liver cancer. | 24802132 |
| Carcinoma of lung | Epigenetic Alterations | Real-time RT-PCR was used to quantify the selected miRNAs known to be play key roles in lung cancer. | 24802132 |
| Hollings Cancer Center, Neoplasms, Neoplasm Metastasis | Epigenetic Alterations | CT-PRFA is a effective treatment for primary NSCLCs and secondary lung tumors from HCC and the efficacy may be related to its ability to normalize deregulated expression of miRNAs: upregulating tumor suppressor miRNAs and downregulating oncomiRs. | 24802132 |
| Stomach Carcinoma | Epigenetic Alterations | Finally, we show that JMJD2A level is correlated with the level of the pro-apoptotic microRNA miR-34a in gastric cancer tissues and JMJD2A represses the expression of miR-34a by decreasing its promoter activity. | 24802408 |
| Refractory Cytopenia of Childhood, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Downregulation of miRNA expression has been identified as a novel feature of renal cell carcinoma (RCC). | 24802708 |
| Neoplasms | Epigenetic Alterations | Our findings indicate that the miR-200 family of microRNAs, and miR-429 in particular, play a critical role in the functioning of OC metastasizing cells and that targeted delivery of miR-429, and perhaps other miR-200 family members, in combination with platinum-based chemotherapies may be an effective strategy in reducing OC metastasis and tumor recurrence. | 24802724 |
| Hollings Cancer Center | Epigenetic Alterations | Fourteen frequently deregulated miRNAs in HCC (miR-17-5p, miR-18a, miR-21, miR-34a, miR-122, miR-195, miR-210, miR-214, miR-221, miR-222, miR-223, miR-224, miR-140, miR-328) were tested by qRT-PCR. | 24804874 |
| Neoplasm Metastasis | Epigenetic Alterations | Argonaute 2 (AGO2) is the core effector protein of the miRNA-induced silencing complex and overexpression of AGO2 might enhance tumor metastasis. | 24805183 |
| Neoplasm Metastasis | Epigenetic Alterations | Evidence in literature has demonstrated that some microRNAs (miRNAs) play a pivotal role in most solid tumor metastasis. | 24805183 |
| Stomach Carcinoma | Epigenetic Alterations | Dysregulated miRNAs in gastric cancer are usually screened by miRNA microarray from clinical samples, however, reports have indicated that results of each miRNA microarray screening are considerably different, and dysregulated miRNAs, especially downregulated miRNAs were contradictory. | 24805774 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | The Human Cancer Pathway Finder miRNA PCR array could be used to screen dysregulated miRNAs effectively, and 4 screened miRNAs, mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p were found to be downregulated in gastric cancer. | 24805774 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Clinical significance and bioinformatic analysis on the target genes of these 4 miRNAs indicated that they were deeply involved in tumorigenesis, suggesting roles such as miRNA tumor suppressors in gastric cancer tumorigenesis which could be applied in gastric cancer diagnosis and prognosis. | 24805774 |
| Stomach Carcinoma | Epigenetic Alterations | Thirty-eight miRNAs were upregulated, and four miRNAs were downregulated in gastric cancer cell lines. | 24805774 |
| Lymphatic Invasion Assessment, Stomach Carcinoma, Venous Invasion, Metastasis | Epigenetic Alterations | Clinical significance of 4 miRNAs including mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tissue compared with adjacent non-tumor tissues of 58 patients indicated that the low-expression group of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p showed more extensive lymph node metastasis, lymphatic invasion, venous invasion, high-stage Borrmann type, lymphatic invasion and poor differentiation than that of the high-expression groups, respectively (P<0.05; kh2 test). | 24805774 |
| Primary malignant neoplasm | Epigenetic Alterations | Enriched GO terms showed that targeted genes of the 4 miRNAs concentrated on 339 terms, 24 of 339 terms are associated with cancer tumorigenesis. | 24805774 |
| MIR152 gene | Epigenetic Alterations | The results obtained by miRNA microarrays of differential expression with hsa-miR-106b-3p, hsa-miR-152, hsa-miR-200a-3p, hsa-miR-381, and hsa-miR-429 were confirmed by real-time PCR. | 24805828 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. | 24805877 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-148b expression is decreased in hepatocellular carcinoma and associated with prognosis. | 24805877 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-148a (miR-148a) has recently been found to be involved in many critical processes in human malignancies. | 24805877 |
| Liver carcinoma | Epigenetic Alterations | Epigenetic high regulation of ATAD2 regulates the Hh pathway in human hepatocellular carcinoma. | 24805933 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Up-regulation of microRNA-183-3p is a potent prognostic marker for lung adenocarcinoma of female non-smokers. | 24805982 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-183 (miR-183) has various expression patterns in types of human cancers. | 24805982 |
| melanoma | Epigenetic Alterations | Here, we explore the application of chromatin conformation capture technology to generate a diagnostic epigenetic barcode for melanoma. | 24807349 |
| Carcinoma, Metastasis | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) play key roles in the progression and metastasis of some carcinomas. | 24810858 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Long noncoding RNA SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis. | 24810925 |
| Neoplasms | Epigenetic Alterations | We studied if DNA methylation might contribute to inactivation of gene/microRNA (miRNA) in the TP53 tumour suppressor network. | 24811488 |
| Acute Promyelocytic Leukemia | Epigenetic Alterations | Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia. | 24811488 |
| Neoplasms | Epigenetic Alterations | miR-34b/c is a tumour suppressor miRNA in APL. | 24811488 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/b-catenin signaling pathway genes. | 24811787 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | The onset and progression of colorectal cancer (CRC) involves a cascade of genetic and/or epigenetic events. | 24811787 |
| Sample Size Calculation | Epigenetic Alterations | The aetiology of systemic sclerosis (SSc) is not clear, but there is an emerging evidence of gene-specific epigenetic dysregulation in the pathogenesis of SSc. | 24812288 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice. | 24812324 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Targeting these miRNAs may be a novel therapeutic strategy to prevent AAA. | 24812324 |
| Diabetes Mellitus, Non-Insulin-Dependent, Inflammation | Epigenetic Alterations | Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. | 24812430 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | However, 15,627 sites, representing 7,046 genes including PPARG, KCNQ1, TCF7L2, and IRS1, showed differential DNA methylation in adipose tissue from unrelated subjects with T2D compared with control subjects. | 24812430 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | A total of 1,410 of these sites also showed differential DNA methylation in the twins discordant for T2D. | 24812430 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Genetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D). | 24812430 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Taken together, subjects with T2D exhibit multiple transcriptional and epigenetic changes in adipose tissue relevant to the development of the disease. | 24812430 |
| Medullary carcinoma of thyroid, Aggressive behavior | Epigenetic Alterations | Epigenetic-related gene expression profile in medullary thyroid cancer revealed the overexpression of the histone methyltransferases EZH2 and SMYD3 in aggressive tumours. | 24813658 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic control of gene expression plays a major influence in the development and progression of many cancer types. | 24813658 |
| Lymphoma, Follicular | Epigenetic Alterations | Hypermethylation of DAPK1 promoter gene was found to be a frequent epigenetic alteration in follicular lymphoma (FL). | 24814955 |
| Ductal Breast Carcinoma | Epigenetic Alterations | The results suggest that methylation of promoter sites of ESR1 and PGR is a relatively uncommon event in ductal and lobular breast cancer, and also suggest that the determination of epigenetic states of ESR1 and PGR could represent an alternative or complement to the histopathological expression analysis. | 24815444 |
| Prostate Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer. | 24815849 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our recent studies of the microRNA (miRNA) expression signature in prostate cancer (PCa) indicated that miRNA-218 (miR-218) was significantly downregulated in clinical specimens, suggesting that miR-218 might act as a tumor-suppressive miRNA in PCa. | 24815849 |
| Primary malignant neoplasm | Epigenetic Alterations | Restoration of miR-218 in PCa cell lines (PC3 and DU145) revealed that this miRNA significantly inhibited cancer cell migration and invasion. | 24815849 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | We hypothesized that the aberrant expression of microRNAs (miRNAs) in rheumatoid arthritis (RA) T cells was involved in the pathogenesis of RA. | 24816316 |
| Right arm | Epigenetic Alterations | The expression profile of 270 human miRNAs in T cells from the first five RA patients and five controls were analysed by real-time polymerase chain reaction. | 24816316 |
| Right arm | Epigenetic Alterations | Twelve miRNAs exhibited potentially aberrant expression in RA T cells compared to normal T cells. | 24816316 |
| Breast Cancer Cell | Epigenetic Alterations | MicroRNAs have been demonstrated to have a role in susceptibility and prognosis of various types of human cancer. | 24816919 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA expression signatures and their correlation with clinicopathological features in glioblastoma multiforme. | 24817689 |
| Glioblastoma Multiforme | Epigenetic Alterations | The increasing interest in identifying molecular biomarkers to determine patient prognosis in glioblastoma multiforme (GBM) has resulted in several microRNA (miRNA)-based signatures able to predict progression-free and overall survival. | 24817689 |
| Neoplasms | Epigenetic Alterations | In total, 161 miRNAs were shown to cluster the GBM tumor samples into long- and short-term-surviving patients. | 24817689 |
| Clinical Coordinator | Epigenetic Alterations | Micro(mi)RNAs are noncoding RNAs that recognize their cognate messenger (m)RNA targets by sequence-specific interactions with the 3 untranslated region and are involved in the multistep process of CRC development. | 24817781 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42. | 24817781 |
| Stomach Carcinoma | Epigenetic Alterations | Dysregulation of microRNA biosynthesis enzyme Dicer plays an important role in gastric cancer progression. | 24817967 |
| DICER1 protein, human | Epigenetic Alterations | Dicer is one of the most important components in microRNA biogenesis. | 24817967 |
| Prostate Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Tumor-suppressive microRNA-29s inhibit cancer cell migration and invasion via targeting LAMC1 in prostate cancer. | 24820027 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our recent studies of microRNA (miRNA) expression signatures revealed that microRNA-29s (miR-29s; including miR-29a/b/c) were significantly downregulated in prostate cancer (PCa) and was a putative tumor-suppressive miRNA family in PCa. | 24820027 |
| Carcinogenesis, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Recognition of tumor-suppressive miRNA-mediated cancer pathways provides new insights into the potential mechanisms of PCa oncogenesis and metastasis, and suggests novel therapeutic strategies for treating this disease. | 24820027 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Differential expression of long noncoding RNA in primary and recurrent nasopharyngeal carcinoma. | 24822202 |
| Colorectal Carcinoma | Epigenetic Alterations | Relationship between miRNA-338-3p expression and progression and prognosis of human colorectal carcinoma. | 24824250 |
| Ulcerative Colitis | Epigenetic Alterations | DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis. | 24825593 |
| Inflammation | Epigenetic Alterations | MicroRNA-124a (miR - 124a) is known to have tumor-suppressive function and be methylation-silenced during exposure to chronic inflammation. | 24825593 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer. | 24825851 |
| Colorectal Cancer Pathway | Epigenetic Alterations | In summary, EPAS1 is transcriptionally regulated by DNA methylation in colorectal cancer. | 24825851 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation and mRNA status of EPAS1 have novel prognostic potential for colorectal cancer. | 24825851 |
| Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | MicroRNA-335 inhibits invasion and metastasis of colorectal cancer by targeting ZEB2. | 24829139 |
| Neoplasms | Epigenetic Alterations | MicroRNAs have been suggested to play a vital role in regulate tumor progression and invasion. | 24829139 |
| Primary malignant neoplasm | Epigenetic Alterations | Growing number of long noncoding RNAs (lncRNAs) are emerging as new modulators in cancer origination and progression. | 24833086 |
| Heart failure, Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | MicroRNA (miRNAs) is demonstrated to be present in the blood of humans and has been increasingly suggested as a novel biomarker for various pathological processes in the heart, including myocardial infarction, myocardial remodeling and progression to heart failure. | 24833470 |
| Heart failure | Epigenetic Alterations | Additionally, increased miRNA levels were strongly associated with increased risk of mortality or heart failure within 6 months for miR-328 (OR 7.35, 95 % confidence interval 1.07-17.83, P < 0.001) and miR-134 (OR 2.28, 95 % confidence interval 1.03-11.32 P < 0.001). | 24833470 |
| Heart failure | Epigenetic Alterations | In conclusion, circulating miR-328 and miR-134 could be potential indicators for AMI, and the miRNA levels are associated with increased risk of mortality or development of heart failure. | 24833470 |
| Heart failure, Infarction | Epigenetic Alterations | MiRNAs were assessed for discrimination of a clinical diagnosis of AMI and for association with primary clinical endpoint defined as a composite of cardiogenic death and development of heart failure within 6 months after infarction. | 24833470 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | A MicroRNA cluster at 14q32 drives aggressive lung adenocarcinoma. | 24833665 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | To determine whether different subtypes of lung adenocarcinoma (AC) have distinct microRNA (miRNA) expression profiles, and to identify miRNAs associated with aggressive subgroups of resected lung AC. | 24833665 |
| Neoplasms | Epigenetic Alterations | miR-411 knockdown significantly reduced cell migration in lung AC cell lines and this miRNA was overexpressed in tumors from patients who relapsed systemically. | 24833665 |
| Neoplasms | Epigenetic Alterations | Unsupervised hierarchical clustering of 356 miRNAs identified 3 major clusters of lung AC correlated with stage (P = 0.023), tumor differentiation (P < 0.003), and IASLC histologic subtype of lung AC (P < 0.005). | 24833665 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Down-regulated microRNA-101 in bladder transitional cell carcinoma is associated with poor prognosis. | 24834983 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Down-regulation of microRNA-101 (miR-101) expression has been linked to bladder transitional cell carcinoma (BTCC) development. | 24834983 |
| Colorectal Neoplasms, Neoplasms | Epigenetic Alterations | Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia. | 24837038 |
| Degenerative polyarthritis | Epigenetic Alterations | We demonstrated that global DNA methylation using a high-density array can be a powerful tool in the characterization of OA at the molecular level. | 24838673 |
| Neoplasms | Epigenetic Alterations | Epigenetic alteration of tumor suppressor genes by promoter hypermethylation has played a key role in tumorigenesis, which is an important mechanism as indispensable as gene deletion and mutation. | 24839112 |
| Malignant tumor of colon, Metastasis | Epigenetic Alterations | Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer. | 24840737 |
| Malignant Neoplasms, Metastasis | Epigenetic Alterations | HOTAIR, a cancer-associated long non-coding RNA (lncRNA), is a powerful biomarker of metastasis and poor prognosis in a diverse group of cancers. | 24840737 |
| Cerebral Infarction | Epigenetic Alterations | Identification of miRNA-21 and miRNA-24 in plasma as potential early stage markers of acute cerebral infarction. | 24841240 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Global fecal microRNA profiling in the identification of biomarkers for colorectal cancer screening among Asians. | 24841830 |
| Clinical Coordinator | Epigenetic Alterations | Global miRNA profiling uncovered 17 fecal markers (p<0.05) differentially regulated in CRC. | 24841830 |
| Neoplasms | Epigenetic Alterations | Notably, a discrete set of aberrant miRNAs occurred within the tumor, indicating the presence of contributors beyond the exfoliation of tumor cells to the fecal miRNA profile. | 24841830 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Hypermethylation of tumor suppressor promoters is generally accepted to indicate poor prognosis in glioma; however, the DNA methylation patterns associated with different glioma prognoses remain to be elucidated. | 24842301 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is a potential biomarker for early cancer detection. | 24844223 |
| Liver carcinoma | Epigenetic Alterations | Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma. | 24844570 |
| Kidney Diseases | Epigenetic Alterations | Global and specific histone acetylation pattern in patients with Balkan endemic nephropathy, a worldwide disease. | 24845033 |
| Mesothelial Neoplasms | Epigenetic Alterations | Having in mind a possible mechanism and biological role of epigenetic chromatin modification in urothelial tumor development they obtained results may open opportunity for selective therapeutic interventions in patients with BEN. | 24845033 |
| Malignant tumor of cervix | Epigenetic Alterations | Regarding viral DNA methylation, the E2BS1 showed a significantly higher mean methylation frequency compared to E2BS3/4, as previously observed in high-grade precancerous lesions of the uterine cervix. | 24845262 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs), the endogenous noncoding RNAs, are involved in carcinogenesis. | 24846066 |
| Primary malignant neoplasm | Epigenetic Alterations | Two miRNAs, miR-21 and miR-106b were found up-regulated in cancer tissues (P=0.0012 and P<0.001, respectively), while miR-375 down-regulated (P<0.001). | 24846066 |
| Neoplasms | Epigenetic Alterations | Our preliminary data suggest that three miRNAs, miR-21, miR-106b and miR- 375 might become novel tumor markers for LSCC diagnosis. | 24846066 |
| Metastasis | Epigenetic Alterations | MiRNAs have been shown to have important role in oncogenesis, invasion, and metastasis via epigenetic post-transcriptional gene regulation. | 24846313 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. | 24846313 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | The expression of miRNAs in patients with primary breast cancer with LN metastasis and that without LN metastases was compared by miRNA microarray. | 24846313 |
| Metastasis | Epigenetic Alterations | The miRNA microarray initially identified that eight miRNAs (miR-206, miR-3923, miR-181a, miR-92a, miR-421, miR-339-5p, miR-3196, and miR-29b) were downregulated in LN metastasis group, whereas five miRNAs (miR-542-5p, miR-200a, miR-564, miR-451, miR-30c, miR-200b, miR-191-3p, miR-142-5p, and miR-185-5p) were upregulated in LN group when compared with those in NLN group. | 24846313 |
| Malignant Neoplasms, Prostate Cancer Pathway | Epigenetic Alterations | Molecular markers that can discriminate indolent cancers from aggressive ones may improve the management of prostate cancer and minimize unnecessary treatment.Aberrant DNA methylation is a common epigenetic event in cancers and HOXD3 promoter hypermethylation (H3PH) has been found in prostate cancer. | 24847526 |
| B-Cell Lymphomas | Epigenetic Alterations | [Plasma DNA methylation of shp1 in patients with diffuse large B cell lymphoma]. | 24851890 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Aberrant DNA methylation at CpG islands has been implicated as a critical player in colorectal cancer (CRC). | 24852431 |
| Primary malignant neoplasm | Epigenetic Alterations | Furthermore, WIF1 significantly increased the expression of microRNAs pri-let-7a and pri-miR-200c, negative regulators of stemness and cancer progression. | 24853424 |
| Malignant Neoplasms | Epigenetic Alterations | MiR-155 is one of most commonly upregulated miRNAs in malignancies, and regulates multiple pro-oncogenic pathways. | 24854560 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) regulate gene expression and act as tumor suppressors or enhancers in oncogenesis. | 24854593 |
| Malignant Neoplasms, Disease | Epigenetic Alterations | MicroRNAs (miRNAs) are stably expressed in serum, which could serve as great potential prognostic biomarkers in a variety of diseases, including various cancers. | 24858372 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | The expression levels of these five serum miRNAs may serve as novel prognostic biomarkers to predict the clinical outcome of DLBCL patients treated with R-CHOP regimen. | 24858372 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Aberrant DNA methylation is a common epigenetic alteration involved in colorectal cancer (CRC). | 24861485 |
| Breast Carcinoma | Epigenetic Alterations | Association of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients. | 24865188 |
| Bone Cysts, Aneurysmal | Epigenetic Alterations | Levels of miRNA-93 differed significantly in core biopsies of LABC patients with different expressions of ER (estrogen receptor) and PR (progesterone receptor). | 24865188 |
| Breast Carcinoma | Epigenetic Alterations | The assessment of core biopsy miRNA profiles and receptor-based subtypes may identify new signaling pathways for improved breast cancer classification. | 24865188 |
| Malignant tumor of colon | Epigenetic Alterations | Specifically, differences in miRNA expression levels of miR-182 may contribute to decreased survival in AA colon cancer patients. | 24865442 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer (CRC) incidence and mortality are higher in African Americans (AAs) than in Caucasian Americans (CAs) and microRNAs (miRNAs) have been found to be dysregulated in colonic and other neoplasias. | 24865442 |
| Malignant tumor of colon, Primary malignant neoplasm | Epigenetic Alterations | Differential expression of miRNAs in colon cancer between African and Caucasian Americans: implications for cancer racial health disparities. | 24865442 |
| Malignant tumor of colon | Epigenetic Alterations | miRNAs may play a role in the differences between AA and CA colon cancer. | 24865442 |
| Malignant Neoplasms, Childhood Leukemia | Epigenetic Alterations | The extent and role of aberrant DNA methylation in promoter CpG islands (CGIs) have been extensively studied in leukemia and other malignancies. | 24866170 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Among genetic mutations in AML, DNMT3A mutations showed the most prominent association with the DNA methylation pattern, characterized by hypomethylation of CGIs (as compared with DNMT3A wild type cases). | 24866170 |
| Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | In conclusion, we show that, in CN-AML, the most pronounced changes in DNA methylation occur in non-CGI regions and that DNMT3A mutations confer a pattern of global hypomethylation that specifically targets HOX genes. | 24866170 |
| Breast Carcinoma | Epigenetic Alterations | A novel panel of microRNAs provides a sensitive and specific tool for the diagnosis of breast cancer. | 24866395 |
| Breast Carcinoma | Epigenetic Alterations | The results demonstrated that four out of the six candidate miRNAs were significantly downregulated in breast cancer patients (miR-451, P=0.000; miR-148a, P=0.021; miR-27a, P=0.013 and miR-30b, P=0.001). | 24866395 |
| Breast Carcinoma | Epigenetic Alterations | A panel of miRNAs consisting of the four downregulated miRNAs was able to distinguish breast cancer from healthy controls, with an area under the receiver operating characteristic curve of 95.3%, a sensitivity of 94.7% and a specificity of 82.8%. | 24866395 |
| Breast Carcinoma | Epigenetic Alterations | Thus, this panel of miRNAs may be used as a sensitive and specific tool for the diagnosis of breast cancer. | 24866395 |
| Autism Spectrum Disorders | Epigenetic Alterations | Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder. | 24875834 |
| Liver carcinoma | Epigenetic Alterations | To analyze the expression profiles of long non-coding RNAs (lncRNAs) in hepatocellular carcinoma. | 24876753 |
| Primary malignant neoplasm | Epigenetic Alterations | Small noncoding microRNAs (miRNAs) regulate gene expression at posttranscriptional level, thus playing an important role in many aspects of cell pathophysiology, including cancerogenesis and cancer progression. | 24877083 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Comparison of promoter DNA methylation and expression levels of genes encoding CCAAT/enhancer binding proteins in AML patients. | 24878001 |
| melanoma | Epigenetic Alterations | MicroR-125b is a miRNA whose down-regulation seems to be implicated in melanoma progression. | 24878024 |
| Aggressive behavior, melanoma | Epigenetic Alterations | Malignant melanoma is an aggressive tumor that produces exosomes, which contain microRNAs (miRNAs) that could be of utility in following tumoral cell dysregulation. | 24878024 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | High levels of global DNA methylation are an independent adverse prognostic factor in a series of 90 patients with de novo myelodysplastic syndrome. | 24880536 |
| SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | The prognostic impact of global DNA methylation and hydroxymethylation was assessed in 90 patients with de novo myelodysplastic syndrome (MDS). | 24880536 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | This study suggests that global DNA methylation predicts overall survival in myelodysplastic syndromes. | 24880536 |
| Hypertensive disease | Epigenetic Alterations | DNA methylation of human telomerase reverse transcriptase associated with leukocyte telomere length shortening in hyperhomocysteinemia-type hypertension in humans and in a rat model. | 24882549 |
| Neoplasms | Epigenetic Alterations | We found that rDNA locus tended to be hypermethylated in tumor compared to matched normal breast tissues and that the DNA methylation level of several CpG units within the rDNA locus was associated to nuclear grade and to nucleolar size of tumor tissues. | 24884608 |
| Mammary Neoplasms | Epigenetic Alterations | In conclusion, we suggest that rDNA is an important target of epigenetic regulation in breast tumors and that rDNA methylation level is associated to nucleolar size. | 24884608 |
| Stomach Carcinoma | Epigenetic Alterations | Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells. | 24885194 |
| Stomach Carcinoma | Epigenetic Alterations | Two gastric cancer cell lines were treated with IGF-I to induce EMT and levels of transcription factor ZEB2 and microRNA-200c (miR-200c) were measured. | 24885194 |
| Prostate Cancer Pathway, Prostatic Cancer, Castration-Resistant | Epigenetic Alterations | Moreover, site-specific DNA methylation may play an important role in miR-146a expression in androgen-dependent prostate cancer progression to androgen-independent prostate cancer and therefore provides a potentially useful biomarker for assessing drug efficacy in prostate cancer. | 24885368 |
| Behavior | Epigenetic Alterations | microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors. | 24886316 |
| Lymphoid leukemia | Epigenetic Alterations | Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding. | 24886876 |
| Childhood Leukemia | Epigenetic Alterations | MicroRNA dysregulation is a common event in leukemia. | 24886876 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Mutations in epigenetic modifiers were reported in patients with acute myeloid leukaemia (AML) including mutations in DNA methyltransferase 3A gene (DNMT3A) in 20%-30% patients and mutations in isocitrate dehydrogenase 1/2 gene (IDH1/2) in 5%-15% patients. | 24887327 |
| Ovarian Serous Adenocarcinoma, Cessation of life | Epigenetic Alterations | Programmed cell death 4 and microRNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions. | 24888238 |
| Neoplasms, Cessation of life | Epigenetic Alterations | Programmed cell death 4 (PDCD4) is a tumor suppressor gene whose expression is directly controlled by microRNA-21 (miR-21). | 24888238 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Comparison of long non-coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma. | 24888564 |
| Primary malignant neoplasm | Epigenetic Alterations | Non-coding RNAs, in particular microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been widely reported to be important in the regulation of tumorigenesis and cancer development. | 24888564 |
| Esophageal Neoplasms | Epigenetic Alterations | However, to the best of our knowledge, investigation of the expression profiles of lncRNAs and a comparison of the involvement of lncRNAs, miRNAs and messenger RNAs (mRNAs) in esophageal tumorigenesis and development have not previously been performed. | 24888564 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Furthermore, the results indicated a high level of similarity in the potential function of lncRNAs, miRNAs and mRNAs in the processes of ESCC development. | 24888564 |
| MMP8 wt Allele | Epigenetic Alterations | Our findings indicate that both genetic and epigenetic RB1 changes may contribute to the pathogenesis of HNC in the Pakistani population. | 24888624 |
| Adrenocortical carcinoma | Epigenetic Alterations | MicroRNA expression patterns in adrenocortical carcinoma variants and clinical pathologic correlations. | 24890943 |
| Ductal Carcinoma | Epigenetic Alterations | VGLL1 and miR-934 expression miRNA profiling was carried out on frozen samples of grade 3 invasive ductal carcinomas. | 24891455 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | RNA-seq data from The Cancer Genome Atlas (TCGA) was used to confirm differences in VGLL1 and miR-934 expression in different breast cancer subtypes, and to correlate their expression with that of other genes and miRNAs. | 24891455 |
| Breast Carcinoma, Triple-Negative Breast Cancer Finding | Epigenetic Alterations | Of 28 miRNAs differentially expressed in estrogen receptor (ER)-positive and ER-negative grade 3 breast carcinomas, miR-934 was most strongly upregulated in ER-negative carcinomas, and its expression was correlated with that of VGLL1. | 24891455 |
| Clinical Coordinator | Epigenetic Alterations | Additionally, TaqMan Human MicroRNA Array Set v2.0 was used to profile the expression of 667 miRNAs in 14 normal colon mucosa and 46 microsatellite stable stage II CRC patients. | 24892549 |
| Clinical Coordinator | Epigenetic Alterations | Finally, combining the functional screening with profiling of CRC tissue samples we identified clinically relevant miRNAs and miRNA targets in CRC. | 24892549 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) play a critical role in many biological processes and are aberrantly expressed in human cancers. | 24892549 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer. | 24892549 |
| Neoplasms | Epigenetic Alterations | Particular miRNAs function either as tumor suppressors or oncogenes and appear to have diagnostic and prognostic significance. | 24892549 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Although numerous miRNAs are dys-regulated in colorectal cancer (CRC) only a small fraction has been characterized functionally. | 24892549 |
| Clinical Coordinator | Epigenetic Alterations | We conclude that the high-throughput screening successfully identified miRNAs that induce apoptosis and/or inhibit proliferation in CRC cells. | 24892549 |
| palladium | Epigenetic Alterations | In addition, we showed a reduced percentage of DNA methylation in the 5UTR region of ADORA2A in advanced PD cases. | 24892887 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | We obtained miRNA expression profiles and corresponding clinical information for 372 LUAD patients from The Cancer Genome Atlas (TCGA), and identified the most significantly altered miRNAs between tumor and normal samples. | 24893932 |
| Liver carcinoma | Epigenetic Alterations | The microRNA-200 family--a potential diagnostic marker in hepatocellular carcinoma? | 24895326 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia. | 24895338 |
| Malignant Neoplasms, Metastasis | Epigenetic Alterations | Curcumin suppresses proliferation, migration, invasion, metastasis and angiogenesis and induces apoptosis by regulating multiple signalling pathways and miRNAs in a wide variety of human malignancies. | 24896104 |
| Carcinogenesis, Nasopharyngeal carcinoma | Epigenetic Alterations | miRNAs play crucial roles in various steps of carcinogenesis in nasopharyngeal carcinoma (NPC); thus, they could serve as critical therapeutic targets for NPC treatment. | 24896104 |
| Breast Carcinoma | Epigenetic Alterations | Evaluation of microRNA-10b prognostic significance in a prospective cohort of breast cancer patients. | 24897960 |
| Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA-10b (miR-10b) has a prominent role in regulating tumor invasion and metastasis by targeting the HOXD10 transcriptional repressor and has been found up-regulated in several tumor types. | 24897960 |
| Malignant Neoplasms | Epigenetic Alterations | An accumulating amount of microRNAs (miRNA) were found aberrantly expressed in human cancers and regulate CSCs. | 24898358 |
| Clinical Coordinator | Epigenetic Alterations | To compare the performance of a new Septin9 DNA methylation based blood test with a fecal immunochemical test (FIT) for CRC screening. | 24901436 |
| Degenerative polyarthritis | Epigenetic Alterations | We measured the expression of 380 miRNA in OA; 12 miRNA were overexpressed under the OA condition (p value, <=0.05; fold change, >2). | 24901787 |
| Feel Pain | Epigenetic Alterations | Some metabolic pathways affected by the miRNA: mRNA ratio are signaling Bone morphogenetic proteins (BMP), Platelet-derived growth factor (PDGF), and Nerve growth factor (NGF), these latter two involved in the process of pain. | 24901787 |
| Cartilage damage | Epigenetic Alterations | Specific miRNA that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. | 24901787 |
| Degenerative polyarthritis | Epigenetic Alterations | Several miRNA could regulate genes and pathways related with development of the disease; eight of these circulating miRNA are described, to our knowledge, for first time in OA. | 24901787 |
| Gallbladder Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer. | 24903309 |
| Gallbladder Carcinoma | Epigenetic Alterations | The precise functions and mechanisms of microRNAs (miR) in gallbladder cancer (GBC) remain elusive. | 24903309 |
| Psoriasis | Epigenetic Alterations | We identified several deregulated miRNAs in the blood from patients with psoriasis including miR-223 and miR-143 which were found to be significantly upregulated in the PBMCs from patients with psoriasis compared with healthy controls (FCH=1.63, P<0.01; FCH=2.18, P<0.01, respectively). | 24909097 |
| Neoplasms | Epigenetic Alterations | Loss of heterozygosity (LOH) and promoter hypermethylation analysis revealed that deletion and/or aberrant epigenetic modulation of PCDH20 gene account for its downregulation, at least in a fraction of tumour specimens. | 24910204 |
| ovarian neoplasm | Epigenetic Alterations | Circulating microRNA expression profiles in ovarian cancer. | 24911418 |
| Breast Cancer Cell | Epigenetic Alterations | Recent studies have suggested that miRNA deregulation is associated with the initiation and progression of human cancer. | 24911418 |
| ovarian neoplasm | Epigenetic Alterations | Our results demonstrated that expression levels of eight miRNAs were significantly upregulated in patients with ovarian cancer when compared with a control group (p < 0.05). | 24911418 |
| ovarian neoplasm | Epigenetic Alterations | Expression levels of four miRNAs were found significantly downregulated in patients with ovarian cancer (p < 0.05). | 24911418 |
| ovarian neoplasm | Epigenetic Alterations | In addition, 10 miRNAs were expressed only in the ovarian cancer group and miR-138-5p of these miRNAs is ovarian specific. | 24911418 |
| ovarian neoplasm | Epigenetic Alterations | In conclusion, our study suggests that detecting these ovarian cancer specific miRNAs in plasma might serve as novel non-invasive biomarkers for ovarian cancer. | 24911418 |
| Ischemic stroke | Epigenetic Alterations | microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. | 24911610 |
| Ischemic stroke | Epigenetic Alterations | miRNA from peripheral blood cells of forty-eight patients with ischemic stroke and vascular risk factor controls were compared. | 24911610 |
| Ischemic stroke | Epigenetic Alterations | The gene targets and pathways associated with ischemic stroke that may be regulated by the identified miRNA were characterized. | 24911610 |
| Ischemic stroke | Epigenetic Alterations | Several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. | 24911610 |
| Ischemic stroke, Blood Clot | Epigenetic Alterations | These miRNA may regulate leukocyte gene expression in ischemic stroke including pathways involved in immune activation, leukocyte extravasation and thrombosis. | 24911610 |
| Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression. | 24912422 |
| Ovarian Carcinoma | Epigenetic Alterations | Epigenetic alteration of p16 and retinoic acid receptor beta genes in the development of epithelial ovarian carcinoma. | 24913706 |
| Carcinogenesis, ovarian neoplasm | Epigenetic Alterations | Our results suggest that epigenetic alterations of p16 and RAR-b have an important role in ovarian carcinogenesis and that mechanism along with methylation plays a significant role in downregulation of RAR-b gene in ovarian cancer. | 24913706 |
| Aggressive behavior, Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. | 24914134 |
| Aggressive behavior, Childhood Leukemia, Chronic Lymphocytic Leukemia | Epigenetic Alterations | High-level leukemia cell expression of micro-RNA 155 (miR-155) is associated with more aggressive disease in patients with chronic lymphocytic leukemia (CLL), including those cases with a low-level expression of z-chain-associated protein of 70 kD. | 24914134 |
| B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma, Hepatitis C | Epigenetic Alterations | To identify molecular characteristics to hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) through a comprehensive miRNAs expression profiling. | 24914240 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | A set of 52 miRNAs define a signature for HCV-associated DLBCL. | 24914240 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | In addition, epigenetic mechanisms, such as changes in DNA methylation patterns, might have a role in the pathophysiology of T2D. | 24914535 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Taken together, newly diagnosed, drug-naive type 2 diabetic patients display specific epigenetic changes at the TCF7L2 promoter as compared to age- and BMI-matched controls. | 24914535 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Methylation in TCF7L2 promoter is further correlated with fasting glucose in peripheral blood DNA, which sheds new light on the role of epigenetic regulation of TCF7L2 in T2D. | 24914535 |
| Hypopharyngeal Squamous Cell Carcinoma, Neoplasms | Epigenetic Alterations | Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature. | 24918822 |
| Primary malignant neoplasm | Epigenetic Alterations | Restoration of miR-451a in cancer cell lines revealed that this miRNA significantly inhibited cancer cell migration and invasion. | 24918822 |
| Malignant Neoplasms, Metastasis, Neoplasms | Epigenetic Alterations | Identification of differentially expressed miRNAs and their regulated molecular targets in tumour cells might enhance our understanding of the molecular mechanisms of metastasis in human cancers. | 24918822 |
| Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | Similar data are lacking in Chinese population where different genetic, lifestyle and environmental factors may affect DNA methylation and its risk relationship with CHD. | 24918913 |
| Diabetes Mellitus, Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | Potential CHD risk factors such as older age, elevated total cholesterol, and diagnosis of diabetes may have impact on global DNA methylation, whereby exerting their effect on CHD risk. | 24918913 |
| Carcinogenesis | Epigenetic Alterations | Buccal microRNA dysregulation in lung field carcinogenesis: gender-specific implications. | 24919547 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have been shown to be reliable early biomarkers in a variety of cancers including that of lung. | 24919547 |
| Carcinoma of lung | Epigenetic Alterations | We ascertained whether the biomarker potential of miRNAs could be validated in microscopically normal and easily accessible buccal epithelial brushings from cigarette smokers as a consequence of lung cancer linked field carcinogenesis. | 24919547 |
| Carcinoma of lung | Epigenetic Alterations | We found that compared to neoplasia-free subjects, a panel of 68 miRNAs were upregulated and 3 downregulated in the normal appearing buccal mucosal cells collected from patients harboring lung cancer (n=76). | 24919547 |
| Chronic Obstructive Airway Disease, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease. | 24921089 |
| Primary Neoplasm | Epigenetic Alterations | DNA methylation alterations on 1,928 probes occurred in N samples relative to normal lung tissue from patients without primary lung tumors, and were inherited by, or strengthened in, T samples. | 24921089 |
| Chronic Obstructive Airway Disease, Aggressive behavior, Carcinogens, Neoplasms | Epigenetic Alterations | DNA methylation profiles reflecting carcinogenetic factors such as smoking and COPD appear to be established in non-cancerous lung tissue from patients with LADCs and may determine the aggressiveness of tumors developing in individual patients, and thus patient outcome. | 24921089 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | As microRNAs (miRNA) may play important roles in tumorigenesis by regulating the expression of proto-oncogenes or tumor suppressor genes, the present study analyzed single nucleotide polymorphisms (SNPs) located in miRNA and miRNA-binding sites of various genes and their impact on prognosis for 452 patients with early breast cancer. | 24922658 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-224 upregulation and AKT activation synergistically predict poor prognosis in patients with hepatocellular carcinoma. | 24923856 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Previous evidence has shown that microRNA (miR)-224 may function as an onco-miRNA in hepatocellular carcinoma (HCC) cells by activating AKT signaling. | 24923856 |
| Ovarian Carcinoma | Epigenetic Alterations | Exosome-derived miRNAs and ovarian carcinoma progression. | 24925027 |
| Primary malignant neoplasm | Epigenetic Alterations | Collectively, these data demonstrate the central role of miRNAs and their content in the biology of this cancer. | 24925027 |
| Breast Carcinoma | Epigenetic Alterations | This is the first evidence of a significant association between genetic and epigenetic alterations in breast cancer using blood-based tests. | 24927296 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | Epigenetic silencing of TSHR gene in thyroid cancer patients in relation to their BRAF V600E mutation status. | 24927793 |
| Carcinoma of lung | Epigenetic Alterations | A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival. | 24927902 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Sox2 overlapping transcript (Sox2ot) is a long noncoding RNA (lncRNA), localized on human chromosome 3q26.33, which is frequently amplified in lung squamous cell carcinomas (SCCs). | 24927902 |
| atherosclerotic | Epigenetic Alterations | These data show a statistically significant correlation of the analyzed miRNA with increased lipids, specifically with a- and b-lipoproteins, and CRP and IL-1b levels in HL and/or HG sera, suggesting a contribution of these miRNAs to the atherosclerotic process. | 24928089 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Circulating microRNA profiling in patients with advanced non-squamous NSCLC receiving bevacizumab/erlotinib followed by platinum-based chemotherapy at progression (SAKK 19/05). | 24928469 |
| Neoplasms | Epigenetic Alterations | Prognostic and predictive miRNA expression profiles were identified by Spearmans rank correlation test (percentage tumor shrinkage) or log-rank testing (for time-to-event endpoints). | 24928469 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Circulating miRNA profiling should further be validated in external cohorts for the selection and monitoring of systemic treatment in patients with advanced NSCLC. | 24928469 |
| MIR29A gene | Epigenetic Alterations | Ten miRNAs were significantly associated with OS, with hsa-miR-29a being the strongest prognostic marker (HR=6.44, 95%-CI 2.39-17.33). | 24928469 |
| Virus Diseases | Epigenetic Alterations | MicroRNA miR-J1-5p as a potential biomarker for JC virus infection in the gastrointestinal tract. | 24932487 |
| Clinical Coordinator | Epigenetic Alterations | Herein, we determined the pattern of JCV miRNA expression in clinical specimens from healthy subjects and CRC patients. | 24932487 |
| Clinical Coordinator, Colonic Neoplasms, Virus Diseases | Epigenetic Alterations | JC virus-specific miR-J1-5p miRNA is a potential biomarker for viral infection, and the lower expression in patients with colonic neoplasia highlights its biological role regulating oncogenic T-Ag expression in CRC. | 24932487 |
| Primary malignant neoplasm | Epigenetic Alterations | The importance of the Piwi-interacting RNA (piRNA) pathway for germ cell maintenance, genome integrity, DNA methylation and retrotransposon control raises possible roles of this pathway in cancer. | 24932571 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer. | 24933454 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) play an important role to contribute carcinogenesis. | 24933454 |
| Arteriosclerosis | Epigenetic Alterations | Homocysteine disrupts EPCs function via inducing the hypermethylation of DDAH2 promoter, suggesting a key role of epigenetic mechanism in the progression of atherosclerosis. | 24934151 |
| Primary malignant neoplasm | Epigenetic Alterations | The Cancer Genome Atlas data were used to examine DNA methylation profiles at 17 CpG sites located in the MSH3 locus. | 24934723 |
| Neoplasms | Epigenetic Alterations | The TCGA data confirmed significantly higher DNA methylation level at the MSH3 promoter region in tumors (P = 0.0024). | 24934723 |
| Liver carcinoma | Epigenetic Alterations | Serum microRNA-210 as a predictive biomarker for treatment response and prognosis in patients with hepatocellular carcinoma undergoing transarterial chemoembolization. | 24935355 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Tumor specific epigenetic alterations can be used as a molecular markers of malignancy, which can lead to better diagnosis, prognosis and therapy. | 24935385 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | Somatic phosphatase and tensin homolog deleted on chromosome 10 (PTEN) mutations and deletions or epigenetic silencing have been observed in multiple tumor types including CRC. | 24935469 |
| Malignant Neoplasms | Epigenetic Alterations | Emerging evidence has shown associations of microRNA-205 (miR-205) with crucial cell processes such as the epithelial-mesenchymal transition (EMT) and aberrant expression with tumorigenesis in many types of human malignancy. | 24935592 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The correlation between DNA methylation and RNA expression of a validated marker, SOX17, was examined in a validation cohort of 61 ESCC patients. | 24936140 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | To understand the biology of tumor recurrence in epithelial ovarian cancer, more studies are necessary, including epigenetic modifications or additional mutations in other genes. | 24936796 |
| Depression, CTCAE | Epigenetic Alterations | Sustained alterations in SERT gene expression profiles, possibly mediated by epigenetic modifications, are a frequent correlate of depression and may thus constitute a putative mediator of GxE interaction. | 24937096 |
| diabetic | Epigenetic Alterations | Treatment-naive, poorly controlled diabetic patients show a significant dysregulation of miRNAs involved in the regulation of the adiponectin pathway, a phenomenon that may be reversed, at least in part, by improved glycemic control. | 24937531 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation status is more reliable than gene expression at detecting cancer in prostate biopsy. | 24937670 |
| Prostatic Hyperplasia | Epigenetic Alterations | Microarray profiling of gene expression and DNA methylation was performed on 16 benign prostatic hyperplasia (BPH) and 32 cancerous and non-cancerous prostate samples extracted by radical prostatectomy. | 24937670 |
| Malignant Neoplasms, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | DNA methylation-based biomarkers reflect the prostate malignancy and might be useful in supporting clinical decisions for suspected PCa following an initial negative prostate biopsy. | 24937670 |
| Breast Carcinoma | Epigenetic Alterations | Oncogenic microRNAs: miR-155, miR-19a, miR-181b, and miR-24 enable monitoring of early breast cancer in serum. | 24938880 |
| Ovarian Serous Adenocarcinoma | Epigenetic Alterations | Characterization of microRNA expression in serous ovarian carcinoma. | 24939816 |
| ovarian neoplasm | Epigenetic Alterations | MiRNA expression profiling showed that 63 miRNAs were downregulated and 43 miRNAs were upregulated in serous ovarian cancer tissues compared with control tissues. | 24939816 |
| Malignant neoplasm of ovary | Epigenetic Alterations | MicroRNAs (miRNAs) have been shown to be dysregulated in ovarian carcinomas. | 24939816 |
| Carcinogenesis | Epigenetic Alterations | The results suggested that the aberrant expression of miRNAs is involved in ovarian carcinogenesis and thus these miRNAs may function as diagnostic and prognostic biomarkers. | 24939816 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) have important regulatory functions in cellular processes and have shown promising potential as prognostic markers for disease outcome in patients with cancer. | 24940606 |
| Early-onset | Epigenetic Alterations | The expression analysis of these miRNAs might be used as biomarkers of the BRCA mutation status of early-onset and/or familial BC. | 24942235 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Recent advances in comprehensive genomic analyses in acute myeloid leukemia have revealed prevalent mutations in regulators of epigenetic phenomena including global DNA methylation status. | 24942948 |
| Lymphoma | Epigenetic Alterations | These results suggest that, in terms of 5 mC/5 hmC immunohistochemistry, B-cell lymphomas with different histological subtypes are associated with distinct global DNA methylation statuses that resemble those of their postulated normal counterparts. | 24942948 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Reduced expression of circulating microRNA-218 in gastric cancer and correlation with tumor invasion and prognosis. | 24944481 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. | 24945256 |
| Malignant Neoplasms, Liver carcinoma, Carcinogenesis, Hollings Cancer Center | Epigenetic Alterations | Aberrant DNA methylation profiles are a characteristic feature of almost all types of cancers including hepatocellular carcinoma (HCC) and play an important role in carcinogenesis. | 24947038 |
| Hollings Cancer Center | Epigenetic Alterations | However, a comparison between three disease cohorts (CH, LC & HCC) revealed no significant difference in levels of DNA methylation at DKK1 promoter. | 24947038 |
| Ulcerative Colitis, Neoplastic disease, Inflammation | Epigenetic Alterations | The lack of correlation between well-known IBD-associated SNPs and UC-neoplasia demonstrated in this study suggests that the development of neoplasia in patients with UC is associated with genetic determinants other than those that predispose to inflammation or results from posttranslational modifications or epigenetic factors rather than germline polymorphisms. | 24947639 |
| Malignant neoplasm of gastrointestinal tract | Epigenetic Alterations | We have previously shown that gastrointestinal cancers display similar epigenetic aberrations. | 24948044 |
| Colorectal Cancer Pathway, Cholangiocarcinoma, Malignant neoplasm of gastrointestinal tract | Epigenetic Alterations | In conclusion, the high methylation frequency of these genes in colorectal- as well as in gastric-, pancreatic- and bile duct cancer confirmed an epigenetic similarity between gastrointestinal cancer types, and simultaneously demonstrated their potential as biomarkers, particularly for colorectal cancer detection. | 24948044 |
| Malignant Neoplasms, Gallbladder Carcinoma | Epigenetic Alterations | Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer. | 24953832 |
| Gallbladder Carcinoma | Epigenetic Alterations | The effects of HOTAIR and miRNA-130a on gallbladder cancer cell invasion and proliferation was tested using in vitro cell invasion and flow cytometric assays. | 24953832 |
| Gallbladder Carcinoma | Epigenetic Alterations | Moreover, a negative correlation between HOTAIR and miRNA-130a was observed in gallbladder cancer tissues. | 24953832 |
| Malignant Neoplasms | Epigenetic Alterations | Together, these results suggest that HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a. | 24953832 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs play important roles in cancer. | 24954107 |
| Multidrug-resistant bacteria | Epigenetic Alterations | Long noncoding RNA MRUL promotes ABCB1 expression in multidrug-resistant gastric cancer cell sublines. | 24958102 |
| Primary malignant neoplasm, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our findings suggest that miR216a is a cancer suppressor miRNA and that overexpression of miR216a is a novel NSCLC treatment strategy. | 24958806 |
| Inflammation | Epigenetic Alterations | Evidence suggests that HTLV-1, via the viral protein Tax, exploits CD4+ T cell plasticity and induces transcriptional changes in infected T cells that cause suppressive CD4+CD25+CCR4+ Tregs to lose expression of the transcription factor FOXP3 and produce IFN-g, thus promoting inflammation. | 24960164 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Serum microRNA expression signatures identified from genome-wide microRNA profiling serve as novel noninvasive biomarkers for diagnosis and recurrence of bladder cancer. | 24961907 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Recent advantages of serum microRNAs (miRNAs) open a new realm of possibilities for noninvasive diagnosis and prognosis of bladder cancer (BC). | 24961907 |
| Prostate Cancer Pathway | Epigenetic Alterations | Our findings strongly indicate that epigenetic silencing of GSTM2 and PENK is a common event in prostate cancer that could be used as a molecular marker for prostate cancer diagnosis. | 24961912 |
| Osteosarcoma | Epigenetic Alterations | To quantify microRNA-9 (miR-9) concentrations in the serum of patients with osteosarcoma; to explore its relationship with clinicopathological characteristics and prognosis of osteosarcoma. | 24962996 |
| Hypertrophy | Epigenetic Alterations | In conclusions, miR-155 is a fibrosis-associated miRNA and may play important role in the pathogenesis of LF hypertrophy. | 24963214 |
| Liver carcinoma | Epigenetic Alterations | Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma. | 24963487 |
| Neoplasms | Epigenetic Alterations | Aberrant DNA methylation is one of the main drivers of tumor initiation and progression. | 24963497 |
| Traditional Serrated Adenoma, Colon Carcinoma | Epigenetic Alterations | DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability. | 24964857 |
| melanoma | Epigenetic Alterations | Long non-coding RNA BANCR promotes proliferation in malignant melanoma by regulating MAPK pathway activation. | 24967732 |
| melanoma, Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been shown to be implicated in the complex network of cancer including malignant melanoma and play important roles in tumorigenesis and progression. | 24967732 |
| melanoma, Metastatic malignant neoplasm to brain | Epigenetic Alterations | DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations. | 24968695 |
| melanoma | Epigenetic Alterations | Little is known about the genetic and epigenetic alterations in melanoma brain metastases (MBMs). | 24968695 |
| Malignant neoplasm of liver | Epigenetic Alterations | MicroRNA-451 regulates activating transcription factor 2 expression and inhibits liver cancer cell migration. | 24968707 |
| Neoplasms | Epigenetic Alterations | Accumulating evidence suggests that microRNAs (miRNAs) can function as oncogenes or as tumor suppressor genes depending on the tissue type or target. | 24968707 |
| Primary malignant neoplasm | Epigenetic Alterations | Therefore, clarification of the specific roles of miRNAs is vital for the diagnosis and treatment of cancer. | 24968707 |
| Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) play an important role in cancer occurrence and development. | 24969565 |
| Diabetic Retinopathy, Vitreous humor | Epigenetic Alterations | Comparisons of microRNA expression profiles in vitreous humor between eyes with macular hole and eyes with proliferative diabetic retinopathy. | 24970617 |
| Diabetic Retinopathy, PDR gene | Epigenetic Alterations | We compared the expression profiles of the miRNAs in the vitreous of eyes with macular hole (MH) to that in eyes with proliferative diabetic retinopathy (PDR). | 24970617 |
| PDR gene | Epigenetic Alterations | The mean number of miRNAs expressed in the vitreous was 63 (55-69) in eyes with MH and 86 (65-117) in eyes with PDR. | 24970617 |
| PDR gene | Epigenetic Alterations | The mean number of miRNAs expressed in the serum was 162 (159-167) in the MH patients and 142 (115-160) in the PDR patients. | 24970617 |
| PDR gene | Epigenetic Alterations | Twenty-six miRNAs were expressed in the vitreous of both MH and PDR eyes. | 24970617 |
| PDR gene | Epigenetic Alterations | In addition, the mean fold changes of three miRNAs, hsa-miR-23a, hsa-miR-320a, and hsa-miR-320b, in the vitreous to serum were significantly higher in the PDR group than in the MH group. | 24970617 |
| Fibrosis Assessment, PDR gene | Epigenetic Alterations | The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR. | 24970617 |
| Dysplasia | Epigenetic Alterations | Mutations of genes involved in DNA methylation, splicing factors other than SF3B1, and genes of the RAS pathway and cohesin complex were independently associated with multilineage dysplasia and identified a distinct subset (51 of 245 patients, 20.8%). | 24970933 |
| Primary malignant neoplasm | Epigenetic Alterations | The changes in DNA methylation status in cancer cells are characterized by hypermethylation of promoter CpG islands and diffuse genomic hypomethylation. | 24971511 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Our findings suggest that miRNA-196a2 T/C polymorphism (rs11614913) is associated with an increased risk of CVD in type 2 diabetes patients. | 24972764 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation in gene promoters is associated with aging and cancer, but the circumstances determining methylation change are unknown. | 24973978 |
| Primary malignant neoplasm | Epigenetic Alterations | Lifestyle, including aspirin use, modulates age-associated DNA methylation change in the colonic epithelium and thereby impacts the evolution of cancer methylomes. | 24973978 |
| Primary malignant neoplasm | Epigenetic Alterations | APA may lead to disruption of microRNA-mediated gene silencing in cancer cells via detachment of microRNA binding sites. | 24975429 |
| Aggressive behavior, Primary malignant neoplasm | Epigenetic Alterations | Our results indicate that the loss of PABPN1, a suppressor of APA, might promote tumor aggressiveness by releasing the cancer cells from microRNA-mediated gene regulation. | 24975429 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | MiRNA profiling of four PCa and four BPH patients with microarray revealed that miR-361-3p, miR-133b and miR-221 were significantly downregulated and miR-203 was upregulated in PSS of PCa patients. | 24976077 |
| Prostate Cancer Pathway | Epigenetic Alterations | Identification of microRNAs differentially expressed in prostatic secretions of patients with prostate cancer. | 24976077 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Four miRNAs, together and individually have much power (AUC; 0.950) than PSA has (AUC; 0.463) to discriminate PCa from BPH patients. | 24976077 |
| Chemosensitivity, Primary malignant neoplasm | Epigenetic Alterations | In parallel, expression of TLR4 and MyD88 mRNA and regulatory microRNAs (miR-21 and miR-146a) was assessed, as well as in a series of chemosensitive and resistant cancer cells lines. | 24977712 |
| Colorectal Cancer Pathway | Epigenetic Alterations | UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution. | 24977734 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cancer biology, and functional lncRNAs can be used for cancer diagnosis and prognosis. | 24977734 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine. | 24980822 |
| Degenerative polyarthritis | Epigenetic Alterations | Genome-wide DNA methylation profiling of >485,000 methylation sites was performed on eroded and intact cartilage from within the same joint of 24 patients undergoing hip arthroplasty for OA. | 24980887 |
| Degenerative polyarthritis | Epigenetic Alterations | Our data implicate epigenetic dysregulation of a host of genes and pathways in OA, including a number of OA susceptibility genes. | 24980887 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. | 24981248 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-630 is a prognostic marker for patients with colorectal cancer. | 24981248 |
| Malignant Neoplasms | Epigenetic Alterations | Among various microRNAs, miR-630 has recently been identified to be implicated in many critical processes in human malignancies. | 24981248 |
| Cerebellar degeneration, MIR206 wt Allele | Epigenetic Alterations | This study provides novel insight into the role of miRNA in cerebellar degeneration and suggests that miR-202 is a key miRNA mediating the pathogenesis of MSA. | 24981430 |
| Breast Carcinoma, MIR206 wt Allele, Breast Diseases | Epigenetic Alterations | To determine their relevance for breast cancer, we quantified the levels of MAGE-A1, -A2, -A3, -A12 and BORIS mRNA, as well as microRNAs let-7b and miR-202 in pre- and postoperative serum of 102 and 34 breast cancer patients, respectively, and in serum of 26 patients with benign breast diseases and 37 healthy women by real-time PCR. | 24983365 |
| Breast Carcinoma, MIR206 wt Allele | Epigenetic Alterations | Transfection of breast cancer cells with synthetic microRNAs and their inhibitors showed that let-7b and miR-202 did not affect the protein expression of MAGE-A1. | 24983365 |
| Stomach Carcinoma | Epigenetic Alterations | Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance. | 24984296 |
| Neoplasms | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) play an important role in basic physiological processes, also affect tumor occurrence and development. | 24984296 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer. | 24986041 |
| melanoma | Epigenetic Alterations | DNA methylation profiles in primary cutaneous melanomas are associated with clinically significant pathologic features. | 24986547 |
| melanoma | Epigenetic Alterations | DNA methylation studies have elucidated a methylation signature distinguishing primary melanomas from benign nevi and provided new insights about genes that may be important in melanoma development. | 24986547 |
| Acute leukemia | Epigenetic Alterations | [Effects of DNA methylation on expression of TIG1 gene in acute leukemia]. | 24989270 |
| Neoplasms | Epigenetic Alterations | DNA methylation of ID4 gene promoter occurred frequently in patients with AL and was found to be highly related to the tumor progression. | 24989275 |
| Cardiovascular Diseases | Epigenetic Alterations | MicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). | 24990426 |
| Autoimmune thyroid disease | Epigenetic Alterations | Associations of single nucleotide polymorphisms in precursor-microRNA (miR)-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases. | 24990808 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent advances in microRNAome have made microRNAs (miRNAs) a compelling novel class of biomarker in cancer biology. | 24992592 |
| Primary malignant neoplasm | Epigenetic Alterations | Long interspersed nuclear element-1 (LINE-1) methylation status, representing global DNA methylation levels, is associated with patient prognosis in several types of cancer. | 24992910 |
| Hepatitis, Liver carcinoma | Epigenetic Alterations | Serum microRNA 143 and microRNA 215 as potential biomarkers for the diagnosis of chronic hepatitis and hepatocellular carcinoma. | 24993656 |
| Hepatitis, Hollings Cancer Center | Epigenetic Alterations | The levels of the two mature miRNAs (miR-143 and miR-215) were detected by probe-based stem-loop quantitative reverse-transcriptase PCR (RT-qPCR) in controls, hepatitis and HCC patients. | 24993656 |
| Mycobacterium Infections | Epigenetic Alterations | microRNA-124 negatively regulates TLR signaling in alveolar macrophages in response to mycobacterial infection. | 24995397 |
| Mycobacterium Infections | Epigenetic Alterations | The emerging roles of microRNAs (miRNAs) in regulating immune responses have attracted increasing attention in recent years; and the alveolar macrophages (AMs) are the main targets of mycobacterial infection, which play a pivotal role in the pathogenesis of Mycobacterium tuberculosis infection. | 24995397 |
| Acute-On-Chronic Liver Failure | Epigenetic Alterations | Aberrant DNA methylation of G-protein-coupled bile acid receptor Gpbar1 predicts prognosis of acute-on-chronic hepatitis B liver failure. | 24995843 |
| Asthma | Epigenetic Alterations | By mapping genome-wide histone modification profiles for subsets of T cells isolated from peripheral blood of healthy and asthmatic individuals, we identified enhancers with known and potential roles in the normal differentiation of human TH1 cells and TH2 cells. | 24997565 |
| Metastasis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25. | 24997798 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The role of epigenetics in distinguishing pathological and clinical subgroups in bladder cancer is not fully characterized. | 24998186 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | miR-152 may act as a tumor suppressor miRNA by also targeting TNFRSF6B and is therefore a potential candidate biomarker for HCC diagnosis, prognosis and molecular therapy. | 24998573 |
| Adenoma | Epigenetic Alterations | We observed that lower levels of LINE-1 DNA methylation in normal appearing background colon mucosa were associated with increased adenoma risk for males, and for both sexes combined. | 24998982 |
| Malignant Neoplasms | Epigenetic Alterations | The methylation of DNA is recognized as a key epigenetic mechanism and evidence for its role in the development of several malignancies is accumulating. | 24998982 |
| Malignant neoplasm of urinary bladder, Primary malignant neoplasm | Epigenetic Alterations | Tumour-suppressive microRNA-24-1 inhibits cancer cell proliferation through targeting FOXM1 in bladder cancer. | 24999187 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Here, we found that microRNA-24-1 (miR-24-1) is significantly reduced in bladder cancer (BC) tissues, suggesting that it functions as a tumour suppressor. | 24999187 |
| HIV-1 Infection Pathway | Epigenetic Alterations | These data suggest that DNA methylation at the IL2 locus in CD4(+) T cells is coupled to immunosenescence and plays a critical role in the broad dysfunction that occurs in polyclonal T cells during HIV-1 infection. | 25001463 |
| HIV Infections | Epigenetic Alterations | Epigenetic repression of interleukin 2 expression in senescent CD4+ T cells during chronic HIV type 1 infection. | 25001463 |
| Neoplasms | Epigenetic Alterations | There may be key molecular differences (eg, DNA methylation changes) in tumors at high risk for progression. | 25003289 |
| Malignant neoplasm of anus | Epigenetic Alterations | Epigenetic events likely play a significant role in the progression of anal cancer and may serve as potential biomarkers. | 25003289 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | miRNA expression was determined using TaqMan assays in 155 tumors from resected NSCLC patients. | 25003366 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are promising molecular markers in multiple cancers and show differences in expression depending on histological subtype. | 25003366 |
| melanoma | Epigenetic Alterations | Association of TNFRSF10D DNA-methylation with the survival of melanoma patients. | 25003639 |
| Breast Carcinoma | Epigenetic Alterations | Alterations in circulating miRNA levels following early-stage estrogen receptor-positive breast cancer resection in post-menopausal women. | 25004125 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNAs (miRNAs) exhibit remarkable stability and may serve as biomarkers in several clinical cancer settings. | 25004125 |
| Primary malignant neoplasm | Epigenetic Alterations | These specific miRNAs may be involved in tumorigenesis and could potentially be used to monitor whether all cancer cells have been removed at surgery and/or, subsequently, whether the patients develop recurrence. | 25004125 |
| X-linked inheritance, Parkinsonian Disorders | Epigenetic Alterations | Because women carriers of the genetic changes specific for X-linked dystonia-parkinsonism are common in the Philippines, the epigenetic factor of nonrandom X-chromosome inactivation may contribute to the skewing of the sex prevalence of parkinsonism toward women in this country, warranting further investigation. | 25004170 |
| Family history | Epigenetic Alterations | Inactivation of SDH and another tricarboxylic acid cycle component, fumarate hydratase (FH), have both been associated with abnormalities of cellular metabolism, responsible for the activation of hypoxic gene response pathways and epigenetic alterations (eg, DNA methylation). | 25004247 |
| Aggressive behavior, CHOANAL ATRESIA, POSTERIOR, Neoplasms | Epigenetic Alterations | In summary, these results demonstrate that epigenetic regulation of miR-152/DNMT1 may play an important role in multiple events that contribute to the aggressiveness of PCa tumors, with an emphasis on AA PCa patients . | 25004396 |
| Prostate Cancer Pathway | Epigenetic Alterations | Herein, we probed the miRNA expression profile of novel AA and CA derived prostate cancer cell lines. | 25004396 |
| Neoplasms | Epigenetic Alterations | We found a unique miRNA signature associated with AA cell lines, independent of tumor status. | 25004396 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. | 25009298 |
| Stomach Carcinoma | Epigenetic Alterations | Genome-wide DNA methylation profiles between 4 metastatic and 4 nonmetastatic gastric carcinomas and their surgical margins (SM) were analyzed using methylated-CpG island amplification with microarray. | 25009298 |
| Metastatic Gastric Carcinoma, Stomach Carcinoma | Epigenetic Alterations | An epigenetic biomarker panel for predicting gastric carcinoma metastasis could have significant clinical impact on the care of patients with gastric carcinoma. | 25009298 |
| Obesity | Epigenetic Alterations | This study provides evidence that obesity influences age driven epigenetic changes, which provides a molecular link between aging and obesity. | 25010727 |
| Islet Cell Tumor | Epigenetic Alterations | Prognostic relevance of aberrant DNA methylation in g1 and g2 pancreatic neuroendocrine tumors. | 25011998 |
| Primary malignant neoplasm | Epigenetic Alterations | These data are consistent with functional relevance of allelic regulation of RAD52 expression by the rs7963551 SNP and miRNA let-7 in cancer cells. | 25012956 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | In conclusion, our results support the hypothesis that genetic variants influencing miRNA-mediated regulation of tumor suppressor genes or oncogenes may contribute glioma susceptibility. | 25012956 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Do epigenetic events take place in the vastus lateralis of patients with mild chronic obstructive pulmonary disease? | 25013984 |
| Muscular Atrophy, muscle mass | Epigenetic Alterations | Several biological mechanisms including epigenetic events regulate muscle mass and function in models of muscle atrophy. | 25013984 |
| Chronic Obstructive Airway Disease, Renal Insufficiency | Epigenetic Alterations | We assessed whether the epigenetic profile may be altered in the vastus lateralis of patients with mild COPD, normal body composition, and mildly impaired muscle function and exercise capacity. | 25013984 |
| Conventional (Clear Cell) Renal Cell Carcinoma, Neoplasms | Epigenetic Alterations | Expression of the tumor suppressive miRNA-23b/27b cluster is a good prognostic marker in clear cell renal cell carcinoma. | 25014580 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Cell-free urinary microRNA-99a and microRNA-125b are diagnostic markers for the non-invasive screening of bladder cancer. | 25014919 |
| Hematuria | Epigenetic Alterations | However, the contaminated blood cells in patients with haematouria significantly altered the expression profiles of urinary microRNA, influencing the test accuracy. | 25014919 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | Evidence implicated the diagnostic significance of microRNAs in whole urine/urine sediments in urothelial carcinoma of the bladder (UCB). | 25014919 |
| Malignant neoplasm of urinary bladder, Transitional cell carcinoma of ureter | Epigenetic Alterations | Hsa-miR-1 downregulates long non-coding RNA urothelial cancer associated 1 in bladder cancer. | 25015192 |
| Diabetic Retinopathy | Epigenetic Alterations | Thus, in diabetic retinopathy, histone methylation at Gclc-ARE4 plays an important role in regulating the Nrf2-Gclc-GSH cascade. | 25016074 |
| Diabetic Retinopathy | Epigenetic Alterations | Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression. | 25016074 |
| Secondary malignant neoplasm of prostate | Epigenetic Alterations | Epigenetic gene regulation has been shown to trigger prostate cancer metastasis and androgen independence. | 25016185 |
| Malignant neoplasm of liver, Hollings Cancer Center, Neoplasms | Epigenetic Alterations | The present findings support the hypothesis that the oncogenic events leading to an ectopic activation of the Y-located protooncogene TSPY and/or inactivating mutation/epigenetic silencing of the X-located tumor suppressor gene TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners. | 25017435 |
| Admitting diagnosis | Epigenetic Alterations | Increasing evidence has suggested that noncoding RNAs (ncRNAs) may be associated with the development of AD. | 25019275 |
| Thyroid carcinoma | Epigenetic Alterations | Genetic or epigenetic events probably play a part in promoting thyroid carcinoma. | 25019383 |
| MLL Partial Tandem Duplication, Neoplasms | Epigenetic Alterations | Twenty gene mutations including class I, class II, class III of epigenetic regulators (IDH1, IDH2, TET2, DNMT3A, MLL-PTD, ASXL1, and EZH2), and class IV (tumor suppressor genes) were analyzed in 67 patients with AML-M0. | 25022553 |
| Malignant tumor of colon | Epigenetic Alterations | We aim to clarify its epigenetic inactivation, biological function and clinical implication in colon cancer. | 25023701 |
| Chondrogenic Neoplasm, Molecular | Epigenetic Alterations | With the characteristic accumulative process of somatic changes as a background, molecular defects in chondrogenesis and aberrant epigenetic control are primarily causative of both benign and malignant cartilaginous tumors. | 25024164 |
| Clinical Coordinator, Dysbiosis | Epigenetic Alterations | Growing evidence has demonstrated that epigenetic modifications and fecal microbiota changes, also known as dysbiosis, are associated with CRC pathogenesis and might be used as surrogate markers of CRC. | 25025467 |
| Neoplasms | Epigenetic Alterations | The aberrant expression of microRNAs (miRNAs) is always associated with tumor development and progression. | 25027403 |
| spiromustine | Epigenetic Alterations | The distribution of coding mutations in driver genes and the correlation with SHM suggest CREBBP and AID to be potential modifiers of genetic and epigenetic co-evolution in FL. | 25027518 |
| Ductal Carcinoma | Epigenetic Alterations | Both microarray and RT-qPCR techniques were used to assess miRNA expression levels in lymph node-positive and -negative human invasive ductal carcinoma tissues. | 25027758 |
| Malignant neoplasm of breast | Epigenetic Alterations | Non-protein-coding microRNAs (miRNAs) have recently been found to be deregulated in breast cancers and, in addition, to be correlated with several clinico-pathological features. | 25027758 |
| Breast Carcinoma | Epigenetic Alterations | Here, we specifically searched for differentially expressed miRNAs in high-risk breast cancer patients as compared to low-risk breast cancer patients. | 25027758 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Differences in miRNA expression in early stage lung adenocarcinomas that did and did not relapse. | 25028925 |
| Adenocarcinoma of lung (disorder), Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We measured miRNA expression only from flash frozen stage I lung adenocarcinomas, excluding other NSCLC subtypes. | 25028925 |
| Neoplasms | Epigenetic Alterations | A unique comparison between adjacent normal lung tissue from relapse and non-relapse groups revealed dramatically different miRNA expression, suggesting dysregulation of miRNA in the environment around the tumor. | 25028925 |
| Neoplasms | Epigenetic Alterations | To assess patient-to-patient variability, miRNA levels in the tumors were normalized to levels in matched adjacent normal lung tissue. | 25028925 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Together our analyses elucidated miRNA not previously linked to lung adenocarcinoma that likely have important roles in its development and progression. | 25028925 |
| Adenocarcinoma | Epigenetic Alterations | Our results also highlight the differences in miRNA expression in normal lung tissue in adenocarcinomas that do and do not recur. | 25028925 |
| Secondary malignant neoplasm of female breast | Epigenetic Alterations | Inhibition of breast cancer metastasis with microRNA-302a by downregulation of CXCR4 expression. | 25030358 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Upregulation of the long noncoding RNA HOTAIR predicts recurrence in stage Ta/T1 bladder cancer. | 25030736 |
| Malignant Neoplasms, Breast Carcinoma | Epigenetic Alterations | Long noncoding RNA HOTAIR has been reported to be expressed in some human cancers such as breast cancer, and it may be positively correlated with patients prognosis. | 25030736 |
| Neoplasms | Epigenetic Alterations | Superimposition of the tumor tissues was carried out in patients with and without epigenetic changes. | 25031184 |
| Malignant Neoplasms | Epigenetic Alterations | Rapidly accumulating studies show that the long non-coding RNAs (lncRNAs) may play essential roles in cancers. | 25031695 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma. | 25031703 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Here, we showed that a novel long non-coding RNA FOXCUT (FOXC1 promoter upstream transcript) and its neighboring gene FOXC1 played a similar important role in the oncogenesis and progression of esophageal squamous cell carcinoma (ESCC). | 25031703 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are noncoding RNAs that regulate multiple cellular processes during cancer progression. | 25031755 |
| Primary malignant neoplasm | Epigenetic Alterations | Low expression of miR-21 by transfection with miRNA expression plasmid led to a decrease in BCL2 expression, which was accompanied by reduced migration and proliferation of the cancer cells. | 25031780 |
| Colorectal Carcinoma | Epigenetic Alterations | Increased expression of miRNA-182 in colorectal carcinoma: an independent and tissue-specific prognostic factor. | 25031782 |
| Carcinogenesis | Epigenetic Alterations | Increasing evidence has revealed that miRNAs play a pivotal role in multiple processes of carcinogenesis, and are being explored as diagnostic, prognostic and predictive biomarker. | 25031782 |
| Heart failure | Epigenetic Alterations | The rationale was to utilize a bioinformatics approach to identify miRNA binding sites in genes with single nucleotide mutations (SNPs) to discover pathways in heart failure (HF). | 25033200 |
| Astrocytoma | Epigenetic Alterations | Prognostic value of coexistence of abnormal expression of micro-RNA-200b and cyclic adenosine monophosphate-responsive element-binding protein 1 in human astrocytoma. | 25033730 |
| Acute myocardial infarction | Epigenetic Alterations | Long noncoding RNAs in patients with acute myocardial infarction. | 25035150 |
| SF3B1 wt Allele, Leukemia, Myelocytic, Acute, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Patients with acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) may respond to treatment with epigenetic-modifying agents. | 25040094 |
| Breast Cancer Cell | Epigenetic Alterations | miRNA-21 (miR-21) appears to be important in the tumourigenesis of almost all types of human cancer. | 25041158 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival. | 25043310 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA profile in very young women with breast cancer. | 25047087 |
| Breast Carcinoma | Epigenetic Alterations | To our knowledge, this is the first time that a validated microRNA profile, distinctive to breast cancer in very young women, has been presented. | 25047087 |
| Malignant tumor of colon | Epigenetic Alterations | Combined nuclear expression of histone modifications H3K4me3, H3K9me3 and H4K20me3 is prognostic in early-stage colon cancer. | 25047223 |
| Tetranitromethane, Malignant tumor of colon | Epigenetic Alterations | The histone methylation markers only showed prognostic value in early-stage (TNM stage I and II) colon cancer. | 25047223 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Identification of a DNA methylome profile of esophageal squamous cell carcinoma and potential plasma epigenetic biomarkers for early diagnosis. | 25050929 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Combination epigenetic treatment (EGT) utilizing DNA methyl transferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi) may be more efficacious than single agent treatment in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). | 25051119 |
| Stage II Colon Cancer AJCC v7 | Epigenetic Alterations | Redefining high-risk patients with stage II colon cancer by risk index and microRNA-21: results from a population-based cohort. | 25051407 |
| Neoplasms | Epigenetic Alterations | MicroRNA-21 was analysed by qPCR based on tumour tissue. | 25051407 |
| Stage II Colon Cancer AJCC v7 | Epigenetic Alterations | This population-based study supports miRNA-21 as an additional prognostic biomarker in patients with stage II colon cancer. | 25051407 |
| liposarcoma | Epigenetic Alterations | Liposarcoma miRNA signatures identified from genome-wide miRNA expression profiling. | 25052748 |
| liposarcoma | Epigenetic Alterations | To identify the miRNA expression profile of liposarcoma (LPS) that could facilitate detection of LPS, and provide the basis for further investigation of molecular-targeted therapeutic drugs. | 25052748 |
| Neoplasms | Epigenetic Alterations | A real-time quantitative PCR assay was performed to analyze the expression of 1888 miRNAs from 25 LPS tumor tissue samples, 16 samples of adipose tissue adjacent to the tumors and 18 normal adipose tissue samples from patients with LPS. | 25052748 |
| Neoplasms, Lipoma | Epigenetic Alterations | Ten dysregulated miRNAs were identified that effectively distinguished LPS tissue from adipose tissue and benign lipoma tissue, and LPS tumor tissues from normal adipose tissues in LPS patients. | 25052748 |
| Coronary Restenosis | Epigenetic Alterations | A micro RNA-146a polymorphism is associated with coronary restenosis. | 25053223 |
| Chlamydia psittaci infection, Ocular Adnexal Lymphoma | Epigenetic Alterations | Genome-wide DNA methylation profiles according to Chlamydophila psittaci infection and the response to doxycycline treatment in ocular adnexal lymphoma. | 25053874 |
| Neoplasms | Epigenetic Alterations | MiRNAs are small noncoding RNAs that have been implicated in tumor development. | 25053875 |
| Pterygium | Epigenetic Alterations | MiRNA-221 negatively regulated downstream p27Kip1 gene expression involvement in pterygium pathogenesis. | 25053875 |
| Pterygium | Epigenetic Alterations | Here, we hypothesize that b-catenin-associated miRNA, miRNA-221, and downstream p27Kip1 gene expression are correlated with the pathogenesis of pterygium. | 25053875 |
| SF3B1 wt Allele | Epigenetic Alterations | Speculating that differences in the expression of genes and microRNA (miRNA) in control and MDS-derived erythroid progenitors may cause ineffective erythropoiesis, we sorted common megakaryocyte-erythroid progenitors (MEPs) in bone marrow cells from three lower-risk MDS patients, and compared expression levels of genes and miRNA with those from controls. | 25056847 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Expressional changes of genes and miRNA in common megakaryocyte-erythroid progenitors from lower-risk myelodysplastic syndrome. | 25056847 |
| SF3B1 wt Allele | Epigenetic Alterations | Some of these alterations in gene and miRNA expression may contribute to the pathogenesis of ineffective hematopoiesis in lower-risk MDS and provide molecular markers for sub-classification and making a prognosis. | 25056847 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miRNAs) are nonprotein-encoding RNAs that regulate gene expression and enable the distinction of benign from malignant tissues in human cancers. | 25057879 |
| Goiter, Papillary thyroid carcinoma, F9 gene | Epigenetic Alterations | miRNA profiling was assessed by TaqMan Array Human MicroRNA A Cards v2.0 in pooled sera from 12 healthy subjects (HS), 12 nodular goiters (NG), and 12 patients with papillary thyroid cancer (PTC) (cohort 1). | 25057879 |
| F9 gene | Epigenetic Alterations | These miRNAs were further validated in a second cohort of sera from 79 PTC, 80 NG, and 41 HS. | 25057879 |
| Glioblastoma Multiforme | Epigenetic Alterations | Correlation between EGFR amplification and the expression of microRNA-200c in primary glioblastoma multiforme. | 25058589 |
| Glioblastoma Multiforme | Epigenetic Alterations | This microRNA plays an important role in epithelial-mesenchymal transition, but its implication in the behavior of glioblastoma is largely unknown. | 25058589 |
| Neoplasms | Epigenetic Alterations | Our results showed that microRNA-200c and E-cadherin expression are down-regulated, while ZEB1 is up-regulated, when tumors showed a high level of EGFR amplification. | 25058589 |
| Hollings Cancer Center | Epigenetic Alterations | In conclusion, the miRNA-149C>T and miR-499A>G polymorphisms were found to play an important role for HCC risk in China. | 25061729 |
| Malignant Neoplasms, Stomach Carcinoma, Metastasis | Epigenetic Alterations | Long non-coding RNA HOTAIR (HOX transcript antisense RNA) recently emerged as a promoter of metastasis in various cancers including gastric cancer. | 25063030 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA 520d-3p inhibits gastric cancer cell proliferation, migration, and invasion by downregulating EphA2 expression. | 25063221 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant expression of microRNAs (miRNAs) has been shown to play important roles in cancer progression as a result of changes in expression of their target genes. | 25063221 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | DNA methylation of apoptosis genes in rectal cancer predicts patient survival and tumor recurrence. | 25064172 |
| Primary malignant neoplasm | Epigenetic Alterations | The study of epigenetic regulation of apoptosis genes provides more insight in the tumorigenic process in rectal cancer and might be helpful in further refining treatment regimens for individual patients. | 25064172 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Prognostic potential of microRNA-138 and its target mRNA PDK1 in sera for patients with non-small cell lung cancer. | 25064732 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | microRNA (miR)-138 has been recognized as a potential tumor suppressor via regulating 3-phosphoinositide-dependent protein kinase-1 (PDK1) expression in non-small cell lung cancer (NSCLC) cells. | 25064732 |
| Communicable Diseases, Hepatitis, Hepatitis C | Epigenetic Alterations | Hepatic expression of miR-122, miR-126, miR-136 and miR-181a and their correlation to histopathological and clinical characteristics of patients with hepatitis C. It has been shown for hepatitis C virus (HCV) infection that host miRNAs contribute to the replication of the viral RNA genome. | 25065618 |
| Post-Traumatic Stress Disorder | Epigenetic Alterations | Longitudinal epigenetic variation of DNA methyltransferase genes is associated with vulnerability to post-traumatic stress disorder. | 25065861 |
| Post-Traumatic Stress Disorder | Epigenetic Alterations | Epigenetic differences exist between trauma-exposed individuals with and without post-traumatic stress disorder (PTSD). | 25065861 |
| Post-Traumatic Stress Disorder, Traumatic injury | Epigenetic Alterations | It is unclear whether these epigenetic differences pre-exist, or arise following, trauma and PTSD onset. | 25065861 |
| Post-Traumatic Stress Disorder | Epigenetic Alterations | DNAm among trauma-exposed individuals shows both longitudinal changes and pre-existing epigenetic states that differentiate individuals who are resilient versus susceptible to PTSD. | 25065861 |
| Post-Traumatic Stress Disorder | Epigenetic Alterations | These distinctive DNAm differences within DNMT loci may contribute to genome-wide epigenetic profiles of PTSD. | 25065861 |
| Gallbladder Carcinoma, Cholecystitis | Epigenetic Alterations | Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile. | 25066711 |
| Cholecystitis | Epigenetic Alterations | Global DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0.01) and ESR1 (p = 0.05) were significantly different in GBC when compared with cholecystitis. | 25066711 |
| Cirrhotic, Hypertensive disease | Epigenetic Alterations | The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS. | 25068403 |
| Liver diseases | Epigenetic Alterations | Circulating miRNA-34a is increased in blood of patients with different liver diseases when compared to healthy controls. | 25068403 |
| Cirrhotic, Portal Hypertension | Epigenetic Alterations | However, the origin of miRNA-34a and its possible relationship with hemodynamics and outcome in cirrhotic patients with portal hypertension is unknown. | 25068403 |
| Cirrhotic, Hypertensive disease | Epigenetic Alterations | We analyzed the levels of miRNA-34a in cirrhotic patients with severe portal hypertension. | 25068403 |
| Cirrhotic, Hypertensive disease | Epigenetic Alterations | Even though higher levels of miRNA-34a are possibly associated with better survival at long-term follow-up in cirrhotic patients with severe portal hypertension receiving TIPS, classical prognostic parameters predict the survival better. | 25068403 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm, Carcinoma | Epigenetic Alterations | miRNA hierarchical clustering demonstrated grouping of two main IPMN subgroups: low-grade IPMN versus high-grade IPMN and carcinoma. | 25069861 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-495 induces breast cancer cell migration by targeting JAM-A. | 25070379 |
| Breast Carcinoma | Epigenetic Alterations | Taken together, our findings suggest that miR-495 could facilitate breast cancer progression through the repression of JAM-A, making this miRNA a potential therapeutic target. | 25070379 |
| Breast Carcinoma, Disease | Epigenetic Alterations | The deregulated expression of miRNAs is associated with a variety of diseases, including breast cancer. | 25070379 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer. | 25071007 |
| Suicide, Behavior | Epigenetic Alterations | Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors. | 25073599 |
| Colorectal Lymphoma, Neoplasms | Epigenetic Alterations | Prognostic microRNA expression signature from examination of colorectal primary and metastatic tumors. | 25075017 |
| Clinical Coordinator, Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | While previous studies have described associations between specific microRNAs and colorectal cancer (CRC) metastasis, our understanding of microRNA regulation of metastatic spread remains largely unexplored. | 25075017 |
| Secondary malignant neoplasm of liver, Neoplasms | Epigenetic Alterations | To identify microRNAs critical for disease progression, we measured microRNA expression in primary CRC tumors and synchronous liver metastases in 19 cases using quantitative polymerase chain reaction (qPCR) arrays. | 25075017 |
| Primary Neoplasm, Secondary malignant neoplasm of liver | Epigenetic Alterations | We identified 16 microRNAs significantly differentially expressed between primary tumors and liver metastases that distinguish primary tumors and liver metastases by hierarchical clustering. | 25075017 |
| Neoplasms | Epigenetic Alterations | Combinations of microRNAs expressed in the primary tumor and in the metastatic tumor are associated with survival, but these signatures have no microRNAs in common. | 25075017 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Our results may have important implications for treatment of DLBCL by epigenetic regulation. | 25076845 |
| Primary malignant neoplasm | Epigenetic Alterations | A single nucleotide polymorphism (SNP) in a miRNA sequence may alter miRNA expression and/or maturation, which was proposed to associate with the development and progression of cancer. | 25078482 |
| Palmar-plantar erythrodysesthesia syndrome | Epigenetic Alterations | Comparisons of the plasma miRNA profiles after NAC and AC suggested that chemotherapy-induced miRNAs originated from both tumoral and non-tumoral compartments. | 25078559 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | This study is the first to demonstrate that NAC specifically induces miRNA expression in plasma and tumor tissue, which might be involved in the anti-tumor effects of chemotherapy in breast cancer patients. | 25078559 |
| Breast Carcinoma | Epigenetic Alterations | In this article, we describe the modifications of circulating miRNAs profile after neoadjuvant chemotherapy (NAC) for breast cancer. | 25078559 |
| Aggressive behavior | Epigenetic Alterations | Among these miRNAs, miR-34a and miR-122 were highly upregulated, notably in pPR patients with aggressive breast cancer. | 25078559 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer. | 25079514 |
| Primary malignant neoplasm | Epigenetic Alterations | Single nucleotide polymorphisms (SNPs) located in the 3-UTR of miRNA target genes could affect miRNA-mediated gene regulation, thereby contributing to the susceptibility or prognosis of cancer. | 25079514 |
| melanoma | Epigenetic Alterations | Dual labeling for the melanocyte lineage marker, MART-1, and the epigenetic marker, 5-hydroxymethylcytosine, a functionally significant indicator that has been shown to distinguish benign nevi from melanoma, was performed on all cases using immunohistochemistry and/or direct immunofluorescence. | 25081754 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4. | 25081869 |
| Pancreatic carcinoma | Epigenetic Alterations | Interaction of Serum microRNAs and Serum Folate With the Susceptibility to Pancreatic Cancer. | 25084000 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm | Epigenetic Alterations | The epigenetic mechanism of tumorigenesis in pancreatic intraductal papillary mucinous neoplasm (IPMN) remains largely unknown. | 25084021 |
| Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | The present work provides evidence to support the association of promoter DNA methylation status with the risk profile of CHD. | 25084356 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer. | 25086633 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in the progression of breast cancer. | 25086633 |
| Breast Carcinoma | Epigenetic Alterations | Some miRNAs, especially the miR-200 family, miR-9, and miR-155 have been reported to be associated with epithelial-mesenchymal transition (EMT) and breast cancer stem cell (BCSC) phenotypes. | 25086633 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Taken together, our findings indicate that LRPPRC is a transcription factor related to ABCB1 expression and highlight the importance of epigenetic regulation in CML resistance. | 25089713 |
| Clinical Coordinator, Carcinogenesis, Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic alterations of specific genes have been reported to be related to colorectal cancer (CRC) transformation and would also appear to be involved in the early stages of colorectal carcinogenesis. | 25091577 |
| Multiple Myeloma | Epigenetic Alterations | Potential relationship and clinical significance of miRNAs and Th17 cytokines in patients with multiple myeloma. | 25092124 |
| MICROPHTHALMIA, SYNDROMIC 7 | Epigenetic Alterations | MiRNA-155 (MiR-155) was found to be upregulated in FLT3-ITD-associated AMLs. | 25092144 |
| Myeloid Cell Differentiation, Childhood Leukemia | Epigenetic Alterations | MicroRNAs (miRNAs) have a pivotal role in myeloid differentiation and leukemia. | 25092144 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Resistant starch fermentation produces butyrate, which can alter microRNA (miRNA) levels in colorectal cancer cells in vitro; effects of red meat and resistant starch on miRNA expression in vivo were unknown. | 25092886 |
| Hepatocarcinogenesis | Epigenetic Alterations | However, the role of epigenetic changes such as aberrant DNA methylation in hepatocarcinogenesis remains largely unclear. | 25093504 |
| Adenoma of large intestine, Primary malignant neoplasm | Epigenetic Alterations | Colorectal adenoma develops into cancer with the accumulation of genetic and epigenetic changes. | 25093594 |
| Kidney Failure, Acute | Epigenetic Alterations | Follow-up biopsies of AKI allografts compared to time-matched protocol biopsies, further baseline adjustment for zero-hour biopsy expression level and validation in independent datasets, revealed a molecular AKI signature holding 20 mRNAs and two miRNAs (miR-182-5p and miR-21-3p). | 25093671 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small, noncoding RNAs of endogenous origin that play an important role in tumor development. | 25095980 |
| Carcinoma of larynx | Epigenetic Alterations | Expression and clinical significance of microRNA-152 in supragalottic laryngeal carcinoma. | 25095980 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Cancer is characterized by mutations, genome rearrangements, epigenetic changes, and altered gene expression that enhance cell proliferation, invasion, and metastasis. | 25100863 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer. | 25100863 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Plasma miRNAs might be promising biomarkers of chronic obstructive pulmonary disease. | 25102970 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Here, we want to find out promising miRNAs for early detection of chronic obstructive pulmonary disease (COPD). | 25102970 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | We found seven miRNAs were special expression in the COPD patients. | 25102970 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | These results suggested that plasma miRNAs could be potential specific biomarker for early detection COPD. | 25102970 |
| Breast Carcinoma | Epigenetic Alterations | Serum microRNA-195 is down-regulated in breast cancer: a potential marker for the diagnosis of breast cancer. | 25103018 |
| Neoplasms | Epigenetic Alterations | MicroRNA-195 (miR-195) is a tumor suppressor that plays an important role in tumorigenesis. | 25103018 |
| Somatic mutation | Epigenetic Alterations | Potential explanations for this relationship include possible autoimmune or estrogen effects of uranium, somatic mutation, epigenetic effects, or effects of some other unidentified accompanying exposure. | 25103365 |
| Primary malignant neoplasm | Epigenetic Alterations | Single-nucleotide polymorphisms (SNP) in miRNA sequence may alter miRNA functions in gene regulation, which, in turn, may affect cancer risk and disease progression. | 25103824 |
| Clinical Coordinator | Epigenetic Alterations | However, the data on association between miRNA SNPs and CRC development are inconsistent. | 25103961 |
| Clinical Coordinator | Epigenetic Alterations | Overall, all genotypes and alleles of miRNA SNPs were distributed equally between control and CRC groups. | 25103961 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have an established role in the development of different cancers. | 25103961 |
| Primary malignant neoplasm | Epigenetic Alterations | Methylenetetrahydrofolate reductase (MTHFR) enzyme is essential for transmethylation reactions including DNA methylation and DNA synthesis and thereby may contribute to cancer prognosis. | 25104092 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer. | 25107371 |
| Malignant neoplasm of urinary bladder, Carcinoma of bladder | Epigenetic Alterations | Our data indicated that miR-19a might act as an oncogenic microRNA in bladder cancer and was significantly up-regulated in bladder cancer carcinogenesis. | 25107371 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The discovery of tumor associated miRNAs in serum of patients supported the use of plasma/serum miRNAs as noninvasive means of cancer detection. | 25107371 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | However, the aberrant expression of miRNAs in bladder cancer patients and their intensive roles and mechanisms in bladder cancer are poorly understood. | 25107371 |
| Atrial Fibrillation | Epigenetic Alterations | Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current. | 25107449 |
| Cardiac Arrhythmia | Epigenetic Alterations | These results suggested that this microRNA could participate in the CAF-induced I(Ca,L) downregulation and in the action potential duration shortening that maintains the arrhythmia. | 25107449 |
| Atrial Fibrillation | Epigenetic Alterations | Alterations in atrial microRNAs could contribute to the protein changes underlying atrial fibrillation-induced atrial electrical remodeling. | 25107449 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Aberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer. | 25107489 |
| Primary malignant neoplasm | Epigenetic Alterations | Global DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - A pilot study. | 25108814 |
| Carcinogenesis | Epigenetic Alterations | DNA methylation is a distinctive molecular pathway in colorectal carcinogenesis. | 25108814 |
| Neoplasms | Epigenetic Alterations | The significant correlation between pre-treatment DNA methylation with tumour response suggests a potential role for methylation as a biomarker of response. | 25108814 |
| Primary malignant neoplasm | Epigenetic Alterations | Analysis of DNA epigenetic mutations in the blood circulating DNA is a prospective trend for creation of noninvasive methods for the diagnosis and treatment efficiency monitoring in cancer. | 25110096 |
| Breast Cancer Cell, Neoplasms | Epigenetic Alterations | MicroRNA-218 (miR-218) is considered a tumor suppressor in human cancer. | 25110121 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | High association between human circulating microRNA-497 and acute myocardial infarction. | 25110754 |
| Adrenocortical carcinoma | Epigenetic Alterations | Inhibin alpha-subunit (INHA) expression in adrenocortical cancer is linked to genetic and epigenetic INHA promoter variation. | 25111790 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Downregulation of microRNA-124 predicts poor prognosis in glioma patients. | 25112530 |
| Loss of Cell Polarity, cervical cancer | Epigenetic Alterations | Epigenetic silencing of CXCR4 promotes loss of cell adhesion in cervical cancer. | 25114911 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer. | 25115396 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Our recent study of microRNA (miRNA) expression signatures in prostate cancer (PCa) has revealed that all members of the miR-23b/27b/24-1 cluster are significantly downregulated in PCa tissues. | 25115396 |
| Metastasis | Epigenetic Alterations | The cell metabolome comprises abundant information that may be predictive of cell functions in response to epigenetic or genetic changes at different stages of cell proliferation and metastasis. | 25115443 |
| Esophageal carcinoma | Epigenetic Alterations | Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis. | 25117314 |
| Tetranitromethane, Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA was extracted using the Taqman((r)) MicroRNA Assay from 46 EC patients at the same tumor node metastasis (TNM) stage, but with different prognoses, who underwent surgery. | 25117314 |
| Neoplasms | Epigenetic Alterations | The tumors of patients with ccRCC had lower expression of miR-126 and miR-378 during the early stages of disease (T1), but higher expression of these miRNAs during the later stages of disease (T2/T3). | 25119741 |
| Carcinogenesis, Refractory Cytopenia of Childhood | Epigenetic Alterations | Our results indicate that EphB1 may be involved in carcinogenesis of RCC, the molecular mechanisms of down-regulation of EphB1 including genetic and epigenetic alterations and the dedicated roles of EphB1 in occurrence and progress of RCC need to be explicated in next step. | 25120806 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small, non-coding RNAs which can function as oncogenes or tumor suppressor genes in human cancers. | 25120851 |
| Malignant neoplasm of urinary bladder, Transitional cell carcinoma of ureter | Epigenetic Alterations | Urothelial cancer associated 1 (UCA1) is a novel non-coding RNA gene, which plays a pivotal role in bladder cancer progression. | 25123267 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are short non-coding RNAs that exert a critical influence on tumorigenesis through post-transcriptional modification and are considered to be potential biomarkers for the diagnosis or prognosis of various cancers. | 25124149 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Expression of microRNA miR-126 and miR-200c is associated with prognosis in patients with non-small cell lung cancer. | 25124149 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Although several miRNAs have been proposed as relevant biomarkers for non-small cell lung cancer (NSCLC), detailed working mechanisms and validated prognostic significance of these miRNAs remain controversial. | 25124149 |
| HIV Infections | Epigenetic Alterations | The miRNA pattern of HIV/HCV samples showed altered expression of 57 and 33 miRNA compared to HCV and HIV infection, respectively. | 25125218 |
| Fibrosis Assessment | Epigenetic Alterations | miRNA-122 and miRNA-22 were associated with relevant fibrosis (FIB-4 >1.45; APRI >1). | 25125218 |
| Fibrosis Assessment | Epigenetic Alterations | Circulating levels of miRNA-122 were independent predictors for relevant fibrosis in HIV patients. | 25125218 |
| Injury of liver | Epigenetic Alterations | Circulating miRNA-122, miRNA-22, and miRNA-34a correlates with the etiology of liver injury in HIV patients. | 25125218 |
| Injury of liver, HIV | Epigenetic Alterations | Circulating microRNAs as a marker for liver injury in human immunodeficiency virus patients. | 25125218 |
| Injury of liver | Epigenetic Alterations | MicroRNAs (miRNAs) are small regulatory RNAs suggested as biomarkers for liver injury. | 25125218 |
| Injury of liver | Epigenetic Alterations | We analyzed the circulating levels of miRNAs in HIV patients with regard to the extent and etiology of liver injury. | 25125218 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA expression in salivary supernatant of patients with pancreatic cancer and its relationship with ZHENG. | 25126577 |
| Buccal Route of Drug Administration | Epigenetic Alterations | A quest for miRNA bio-marker: a track back approach from gingivo buccal cancer to two different types of precancers. | 25126847 |
| Primary malignant neoplasm | Epigenetic Alterations | Deregulation of miRNA expression may contribute to tumorigenesis and other patho-physiology associated with cancer. | 25126847 |
| Oropharyngeal Carcinoma | Epigenetic Alterations | A let-7 microRNA polymorphism in the KRAS 3-UTR is prognostic in oropharyngeal cancer. | 25127693 |
| Patient Satisfaction with Cancer Care Questionnaire | Epigenetic Alterations | OPSCC patients (n=122) were genotyped for ten genetic polymorphisms in pre-miRNAs (pre-mir-146a, pre-mir-196a2), in miRNA biosynthesis genes (Drosha, XPO5) and in miRNA target genes (KRAS, SMC1B). | 25127693 |
| Ischemic stroke | Epigenetic Alterations | miRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke. | 25127724 |
| Cerebrovascular accident | Epigenetic Alterations | In the blood, 287 different miRNAs were detected of which two miRNAs (miR-151a-3p and miR-140-5p) were found upregulated and one miRNA (miR-18b-5p) was found downregulated in the stroke group. | 25127724 |
| Cerebrovascular accident | Epigenetic Alterations | In total, 183 different miRNAs were detected in the CSF, of which two miRNAs (let-7c and miR-221-3p) were found upregulated in relation to stroke. | 25127724 |
| Cerebrovascular accident | Epigenetic Alterations | Some miRNAs occurred exclusively in the CSF including miR-523-3p which was detected in 50 % of the stroke patients, whereas it was completely absent in controls. | 25127724 |
| nervous system disorder | Epigenetic Alterations | Our preliminary results demonstrate that it is possible to detect and profile miRNAs in CSF and blood from patients with neurological diseases. | 25127724 |
| Cerebrovascular accident | Epigenetic Alterations | Some miRNAs appear differentially expressed in the CSF and others in the blood of stroke patients. | 25127724 |
| Colorectal Carcinoma | Epigenetic Alterations | Downregulation of microRNA-498 in colorectal cancers and its cellular effects. | 25128149 |
| Perceived stress scale | Epigenetic Alterations | MiR-181a was the miRNA that most profoundly differed between patients with pSS and healthy individuals; however, similar miRNA-181a expression profiles were found in groups with different disease phenotypes. | 25128511 |
| Virus Diseases, Perceived stress scale | Epigenetic Alterations | In addition to the regulation of human miRNA, many virus-derived miRNA were unexpectedly upregulated in the patients with pSS, suggesting that viral infection of PBMC plays a role in this disease. | 25128511 |
| Alzheimers Disease | Epigenetic Alterations | Alzheimers disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. | 25129075 |
| Admitting diagnosis | Epigenetic Alterations | Our analyses suggest that these DNA methylation changes may have a role in the onset of AD given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network. | 25129075 |
| Primary malignant neoplasm | Epigenetic Alterations | Extracellular microRNAs (miRNAs) embedded in circulating exosomes may serves as prognostic biomarkers in cancer. | 25129854 |
| Neurodegenerative Disorders | Epigenetic Alterations | In addition, microRNA dysregulation contributes to some mental disorders and neurodegeneration diseases. | 25130371 |
| Squamous cell carcinoma, Trauma Symptom Checklist for Children Questionnaire | Epigenetic Alterations | However, the involvement of microRNA during the EMT process in tongue squamous cell carcinoma (TSCC) remains to be determined. | 25130698 |
| TGIF1 gene | Epigenetic Alterations | Ectopic expression of miR-639 with miRNA mimics effectively blocked TGFb-induced EMT in SCC9 and CAL27 cells, but inhibition of miR-639 in SCC9 and CAL27 cells with antisense oligonucleotides induced EMT. | 25130698 |
| Hepatitis, Hepatitis B, Chronic | Epigenetic Alterations | Serum microRNA-124 is a novel biomarker for liver necroinflammation in patients with chronic hepatitis B virus infection. | 25131617 |
| Hepatitis | Epigenetic Alterations | The capacity of serum microRNA-124 levels in discriminating the grade of liver necroinflammation was compared with alanine aminotransferase (ALT) with liver biopsy validation. | 25131617 |
| Hepatitis | Epigenetic Alterations | In patients with normal ALT and a serum HBV DNA load >10(4) copies/mL, receiver operating characteristic (ROC) curve of serum microRNA-124 levels yielded an area under ROC curve (AUC) of 0.840, with 58.3% sensitivity and 91.7% specificity in discriminating between moderate-to-severe liver necroinflammation (G >= 2). | 25131617 |
| Necrosis with inflammation, Hepatitis | Epigenetic Alterations | Patients with considerable liver necroinflammation (G >= 2) had significantly higher serum miRNA-124 levels than those without or with mild necroinflammation (P < 0.0001). | 25131617 |
| Prostatic Cancer, Castration-Resistant, Neoplasms | Epigenetic Alterations | In a mouse xenograft model of androgen-independent prostate cancer, PAX2 knockdown inhibited tumor growth and AR gene expression and also increased DNA methylation of the AR gene. | 25132193 |
| Prostatic Cancer, Castration-Resistant, Primary malignant neoplasm | Epigenetic Alterations | These findings suggested that PAX2 promoted cancer cell growth in androgen-independent prostate cancer by regulating AR gene expression through an epigenetic mechanism. | 25132193 |
| Pancreatic carcinoma | Epigenetic Alterations | Stromal microRNA-21 levels predict response to 5-fluorouracil in patients with pancreatic cancer. | 25132574 |
| Primary malignant neoplasm, ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | MicroRNA-21 (miR-21) is upregulated and inversely associated with survival in many cancer types, including pancreatic ductal adenocarcinoma (PDAC). | 25132574 |
| Secondary malignant neoplasm of prostate | Epigenetic Alterations | Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11-miRNA-541-androgen receptor (AR)-MMP9 signaling. | 25135278 |
| Cell Invasion | Epigenetic Alterations | Targeting these newly identified signals via FGF11-siRNA, miRNA-541 inhibitor or MMP9 inhibitor all led to partially reverse the enhanced PCa cell invasion. | 25135278 |
| Metastasis | Epigenetic Alterations | Together, these results concluded that infiltrating CD4(+) T cells could promote PCa metastasis via modulation of FGF11-miRNA-541-AR-MMP9 signaling. | 25135278 |
| skeletal muscle plasticity | Epigenetic Alterations | Epigenomic regulation of the transcriptome by DNA methylation and posttranscriptional gene silencing by miRNAs are potential environmental modulators of skeletal muscle plasticity to chronic exercise in healthy and diseased populations. | 25138607 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer. | 25139296 |
| Colorectal Neoplasms | Epigenetic Alterations | Aberrant DNA methylation could potentially serve as a biomarker for colorectal neoplasms. | 25139296 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Our results demonstrate that DNA methylation in BLF specimens may be a useful biomarker for the detection of colorectal cancer. | 25139296 |
| Breast Carcinoma | Epigenetic Alterations | Breast cancer is a heterogeneous disease with a highly variable clinical outcome in which both genetic and epigenetic changes have critical roles. | 25139823 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | A three-microRNA signature predicts responses to platinum-based doublet chemotherapy in patients with lung adenocarcinoma. | 25142144 |
| Alzheimers Disease Assessment Scale-Cognitive CDISC Version Questionnaire | Epigenetic Alterations | The three-miRNA signature in surgically resected primary LADC tissues may by clinically useful for predicting responsiveness to platinum-based doublet chemotherapy in patients with LADC recurrence. | 25142144 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Analysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients. | 25143946 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Microarray technology was used to profile miRNA expression in primary tumor and stromal tissue from paraffin embedded material of 51 patients with colorectal cancer. | 25143946 |
| Metastasis, Neoplasms | Epigenetic Alterations | No significant association was found between miRNA expressions and stage at diagnosis, site of primary tumor, first site of metastasis, progression-free, or overall survival. | 25143946 |
| Neoplasms | Epigenetic Alterations | 26 miRNAs resulted differentially expressed with at least 2-fold change in tumor tissue with respect to stroma (16 more expressed in the tumor and 10 more expressed in the stroma). | 25143946 |
| Hormone refractory prostate cancer | Epigenetic Alterations | Methylated Glutathione S-transferase 1 (mGSTP1) is a potential plasma free DNA epigenetic marker of prognosis and response to chemotherapy in castrate-resistant prostate cancer. | 25144624 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNAs are non-coding RNA molecules; their deregulations may contribute to cancer pathogenesis. | 25146331 |
| Asthma Pathway | Epigenetic Alterations | Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma. | 25147914 |
| Asthma Pathway | Epigenetic Alterations | Epigenetic changes including DNA methylation caused by environmental exposures may contribute to the heterogeneous inflammatory response in asthma. | 25147914 |
| Asthma Pathway | Epigenetic Alterations | We have identified characteristic alterations in DNA methylation that are associated with inflammatory phenotypes of asthma and may contribute to the disease mechanisms. | 25147914 |
| Asthma Pathway | Epigenetic Alterations | This network-based characterization may help in the development of epigenetic biomarkers and therapeutic targets for asthma. | 25147914 |
| Juvenile Myelomonocytic Leukemia | Epigenetic Alterations | Aberrant DNA methylation at specific genetic loci is a key molecular feature of juvenile myelomonocytic leukemia (JMML) with poor prognosis. | 25147919 |
| Aggressive behavior | Epigenetic Alterations | The results corroborate the significance of epigenetic modifications in the phenotype of aggressive JMML. | 25147919 |
| Rheumatoid Arthritis | Epigenetic Alterations | Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations. | 25147922 |
| Colorectal Cancer Pathway | Epigenetic Alterations | A miRNA-binding site single nucleotide polymorphism in the 3-UTR region of the NOD2 gene is associated with colorectal cancer. | 25148897 |
| Clinical Coordinator | Epigenetic Alterations | Single nucleotide polymorphisms in miRNA-binding site on gene transcripts are reported to play important role in increased risk of CRC in different population. | 25148897 |
| Pancreatic carcinoma | Epigenetic Alterations | Here we screened miRNAs associated with drug resistance in pancreatic cancer, and identified a panel of miRNAs dysregulated in gemcitabine-resistance pancreatic cancer cells, including 13 downregulated miRNAs and 20 upregulated miRNAs. | 25149530 |
| Metastatic hepatocellular carcinoma | Epigenetic Alterations | DNA methylation-mediated silencing of matricellular protein dermatopontin promotes hepatocellular carcinoma metastasis by a3b1 integrin-Rho GTPase signaling. | 25149533 |
| DPT gene, Hollings Cancer Center | Epigenetic Alterations | We further revealed that the down-regulation of DPT in HCC was due to epigenetic silencing by promoter DNA methylation. | 25149533 |
| Neoplasms, Neoplasm Metastasis | Epigenetic Alterations | Our study provides new evidence for epigenetic control of tumor microenvironment, and suggests matricellular protein DPT may serve as a novel prognostic marker and act as a HCC metastasis suppressor. | 25149533 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | DNA methylation was quantified by highly reproducible bisulfite pyrosequencing assays in two independent CLL series. | 25151957 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact. | 25151957 |
| Hematopoietic Neoplasms | Epigenetic Alterations | Aberrant expression of CTNNA1 is regulated by epigenetic mechanisms including both promoter methylation and histone deacetylation in hematopoietic malignancies. | 25153418 |
| melanoma, Primary malignant neoplasm | Epigenetic Alterations | In addition, we integrated our miRNA signature with publicly available Cancer Genome Atlas data to examine the relevance of these miRNAs to melanoma biology. | 25155861 |
| melanoma | Epigenetic Alterations | Serum-based miRNAs in the prediction and detection of recurrence in melanoma patients. | 25155861 |
| melanoma | Epigenetic Alterations | We recently reported our array-based discovery of prognostic serum miRNAs in melanoma. | 25155861 |
| melanoma | Epigenetic Alterations | Data demonstrate that serum miRNAs can improve melanoma patient stratification over stage and support further testing of miR-15b to guide patient surveillance. | 25155861 |
| Hollings Cancer Center | Epigenetic Alterations | In HCC, TRb1 down-regulation was not the result of hypermethylation of its promoter, but was associated with an increased expression of TRb1-targeting microRNAs ([miR]-27a, -181a, and -204). | 25156012 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | A novel saliva-based microRNA biomarker panel to detect head and neck cancers. | 25156495 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | Five differentially expressed miRNAs were selected from miScript(tm) miRNA microarray data generated using saliva from five HNSCC patients and five healthy controls. | 25156495 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | This diagnostic panel was independently validated using HNSCC miRNA expression data from The Cancer Genome Atlas (TCGA), encompassing 334 tumours and 39 adjacent normal tissues. | 25156495 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are known to play an important role in cancer development by post-transcriptionally affecting the expression of critical genes. | 25156495 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | We found that miR-9 (P <0.0001), miR-134 (P <0.0001) and miR-191 (P <0.001) were differentially expressed between saliva from HNSCC patients and healthy controls, and that these miRNAs provided a good discriminative capacity with area under the curve (AUC) values of 0.85 (P <0.0001), 0.74 (P < 0.001) and 0.98 (P < 0.0001), respectively. | 25156495 |
| Neoplasms | Epigenetic Alterations | However, the exact role of ATM gene and its epigenetic alterations, especially promoter methylation in different grades of brain tumors, remains elusive. | 25159481 |
| Alzheimers Disease | Epigenetic Alterations | Epigenetic modifications in Alzheimers disease: cause or effect? | 25159670 |
| Admitting diagnosis | Epigenetic Alterations | These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women. | 25159673 |
| Neoplasms | Epigenetic Alterations | Differences among brain tumor stem cell types and fetal neural stem cells in focal regions of histone modifications and DNA methylation, broad regions of modifications, and bivalent promoters. | 25163646 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Using ChIP-chip and MeDIP-chip approaches, we localized well-established and prevalent epigenetic marks (H3K27me3, H3K4me3, H3K9me3, DNA methylation) on a genome scale in several lines of putative glioma stem cells (brain tumor stem cells, BTSCs) and, for comparison, normal human fetal neural stem cells (fNSCs). | 25163646 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrational epigenetic marks are believed to play a major role in establishing the abnormal features of cancer cells. | 25163646 |
| Rheumatoid Arthritis | Epigenetic Alterations | Decreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis. | 25164131 |
| Primary malignant neoplasm | Epigenetic Alterations | Loss of epigenetic gene regulation through altered long noncoding RNA (lncRNA) expression seems important in human cancer. | 25165097 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Identification of differentially expressed long noncoding RNAs in bladder cancer. | 25165097 |
| Stomach Carcinoma, Infection caused by Helicobacter pylori | Epigenetic Alterations | Different microRNA expression levels in gastric cancer depending on Helicobacter pylori infection. | 25167801 |
| Stomach Carcinoma | Epigenetic Alterations | miRNA expression in the intestinal type of H. pylori infection-dependent gastric cancer suggests that different gastric can-cer pathogenesis mechanisms could exist between H. pylori-positive and H. pylori-negative gastric cancer. | 25167801 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Urinary cell-free microRNA-106b as a novel biomarker for detection of bladder cancer. | 25168920 |
| Malignant Neoplasms | Epigenetic Alterations | Expression of the long non-coding RNA (lncRNA) LOC285194 was previously shown to be correlated with aggressive clinicopathological features and poor prognosis in several cancers. | 25169763 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-218 is upregulated in gastric cancer after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and increases chemosensitivity to cisplatin. | 25170221 |
| Carcinoma of lung, Malignant neoplasm of lung | Epigenetic Alterations | Changes in DNA methylation status have now been identified as a critical component in the initiation of lung cancer, and the detection of DNA methylation is expected to be an important method for the early diagnosis of lung cancer. | 25172267 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | These results suggest that epigenetic regulation of CHRNB4 may affect tumor progression and survival in patients with NSCLC. | 25172267 |
| Squamous cell carcinoma | Epigenetic Alterations | Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma. | 25174622 |
| Neoplasms | Epigenetic Alterations | MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2. | 25174799 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | An increasing body of evidence indicates that miRNAs have a critical role in carcinogenesis and cancer progression; however, the role of miRNAs in the tumorigenesis of adencarcinoma of gastric esophageal junction (AGEJ) remains largely unclear. | 25174799 |
| Carcinoma of lung | Epigenetic Alterations | The blood-borne miRNA signature of lung cancer patients is independent of histology but influenced by metastases. | 25175044 |
| Lung Neoplasms | Epigenetic Alterations | We further determined the overlap of miRNAs expressed in each subgroup with the 24-miRNA signature of lung tumor patients. | 25175044 |
| Carcinoma of lung | Epigenetic Alterations | In addition, we found a large overlap between the blood-borne miRNAs detected in the three histological subgroups and the previously described 24-miRNA signature that separates lung cancer patients form controls. | 25175044 |
| Small cell carcinoma of lung, Adenocarcinoma, Squamous cell carcinoma of lung, Hematologic Neoplasms, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | There is a common miRNA expression pattern in blood of lung cancer patients that does not allow a reliable further subtyping into NSCLC or SCLC, or into adenocarcinoma and squamous cell lung cancer. | 25175044 |
| Carcinoma of lung | Epigenetic Alterations | The previously described 24-miRNA signature for lung cancer appears not primarily dependent on histological subtypes. | 25175044 |
| Small cell carcinoma of lung, Adenocarcinoma, Squamous cell carcinoma of lung | Epigenetic Alterations | Based on a raw p-value < 0.05, only 18 blood-borne miRNAs were differentially expressed between patients with adenocarcinoma and with squamous cell lung carcinoma, 11 miRNAs between adenocarcinoma and SCLC, and 2 between squamous cell lung carcinoma and SCLC. | 25175044 |
| Small cell carcinoma of lung, Adenocarcinoma, Neoplasms | Epigenetic Alterations | We identified several miRNAs that allowed differentiating between metastatic and non-metastatic tumors both in blood of patients with adenocarcinoma and in blood of patients with SCLC. | 25175044 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | There have been many DNA methylation studies on breast cancer which showed various methylation patterns involving tumour suppressor genes and oncogenes but only a few of those studies link the methylation data with gene expression. | 25175708 |
| Mammary Neoplasms | Epigenetic Alterations | DNA methylation profiling was carried out on 76 fresh frozen primary breast tumour tissues and 25 adjacent non-cancerous breast tissues using the Illumina Infinium((r)) HumanMethylation27 BeadChip. | 25175708 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the PI3K/AKT and MAPK/ERK pathways in ovarian cancer. | 25176450 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) have been shown to play an important role in diverse biological processes and cancer progression. | 25176450 |
| Primary malignant neoplasm | Epigenetic Alterations | Single-nucleotide polymorphisms in microRNAs play important roles in oncogenesis and cancer development. | 25177719 |
| Malignant neoplasm of urinary bladder, Behavior | Epigenetic Alterations | MicroRNA-320c inhibits tumorous behaviors of bladder cancer by targeting Cyclin-dependent kinase 6. | 25178497 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | Increasing evidence has suggested that dysregulation of microRNAs (miRNAs) could contribute to human disease including cancer. | 25178497 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Elevated level of microRNA-21 in the serum of patients with colorectal cancer. | 25178939 |
| Colorectal Cancer Pathway | Epigenetic Alterations | In patients with colorectal cancer, circulating micro RNA-21 (miR-21) is overexpressed and may act as a potential diagnostic and prognostic biomarker. | 25178939 |
| Systemic Scleroderma, Sample Size Calculation | Epigenetic Alterations | As aberrant epigenetic modifications have been linked to the pathogenesis of systemic sclerosis (SSc), we aimed to investigate the role of Sirt1 in fibroblast activation. | 25180292 |
| Asthma Pathway | Epigenetic Alterations | hASMCs from patients with asthma exhibit elevated expression of cytokine-responsive genes, and in some instances this is attributable to an altered histone code and/or microRNA expression. | 25180620 |
| Colorectal Cancer Pathway | Epigenetic Alterations | A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy. | 25183481 |
| hearing impairment | Epigenetic Alterations | Epigenetic regulation might explain the observed difference in age of onset and magnitude of hearing impairment with age. | 25184702 |
| Coronary Arteriosclerosis | Epigenetic Alterations | In our previous experiments, the altered expressions of circulating miRNA-21-5p, miRNA-361-5p and miRNA-519e-5p were confirmed in patients with coronary atherosclerosis by miRNA microarrays. | 25184815 |
| Cardiovascular Diseases | Epigenetic Alterations | The dysregulated expressions of circulating miRNAs have been detected in various cardiovascular diseases. | 25184815 |
| Acute myocardial infarction | Epigenetic Alterations | However, the expression levels of these circulating miRNAs in the early phase of acute myocardial infarction (AMI) are still unknown. | 25184815 |
| Hypoxia | Epigenetic Alterations | Furthermore, cell experiments demonstrated that these plasma miRNAs may originate from injured cardiomyocytes induced by hypoxia. | 25184815 |
| Pulmonary Embolism, Ischemic stroke | Epigenetic Alterations | In addition, the levels of all the three circulating miRNAs in ischemic stroke (IS) and pulmonary embolism (PE) were elevated, whereas the decreased level of plasma miR-519e-5p was only detected in AMI. | 25184815 |
| Malignant tumor of colon | Epigenetic Alterations | C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion. | 25185650 |
| Malignant Neoplasms, Malignant tumor of colon | Epigenetic Alterations | Recently, more and more evidence are rapidly accumulating that long noncoding RNAs (lncRNAs) are involved in human tumorigenesis and misregulated in many cancers, including colon cancer. | 25185650 |
| Multiple Myeloma | Epigenetic Alterations | Activation of LTBP3 gene by a long noncoding RNA (lncRNA) MALAT1 transcript in mesenchymal stem cells from multiple myeloma. | 25187517 |
| Neoplasms | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) are emerging as important regulatory molecules in tumor suppressor and oncogenic pathways. | 25187517 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Downregulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: a possible biomarker to discontinue imatinib safely. | 25187697 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Identification of novel genetic and epigenetic alterations is required for optimal stratification of patients with hepatocellular carcinoma (HCC) at risk for recurrence and adverse prognosis. | 25189544 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant microRNA (miRNA) expression in blood of cancer patients is a common finding. | 25189899 |
| SERPINB3 wt Allele | Epigenetic Alterations | Alterations in miRNA expression patterns in whole blood of OSCC patients. | 25189899 |
| SERPINB3 wt Allele | Epigenetic Alterations | 21 miRNAs were identified to be significantly differentially expressed in whole blood of OSCC patients compared to healthy controls. | 25189899 |
| SERPINB3 wt Allele | Epigenetic Alterations | The aberrant expressions of miR-186, miR-494 and miR-3651 in whole blood of OSCC patients may serve as the basis for establishing minimally-invasive screening methods for OSCC based on miRNAs as biomarkers. | 25189899 |
| Neoplasms | Epigenetic Alterations | More and more evidence reveals that noncoding RNA miR-34b/c and tumor suppressor gene TP-53 independently, and/or jointly, play crucial roles in carcinogenesis. | 25190020 |
| Prostate Cancer Pathway | Epigenetic Alterations | Circulating miRNAs 21 and 221 as biomarkers for early diagnosis of prostate cancer. | 25190021 |
| Prostate Cancer Pathway | Epigenetic Alterations | Our study showed that serum miRNAs 21 and 221 expression profiling tests may be used as specific noninvasive molecular biomarkers for prostate cancer diagnosis due to their higher sensitivity and specificity with a high negative predictive value leading to a decrease in the biopsies taken for patients with elevated serum PSA values. | 25190021 |
| Primary malignant neoplasm | Epigenetic Alterations | Polymorphisms in pre-microRNAs (miRNAs) or mature miRNAs may influence miRNA processing or target binding, thus contributing to tumorigenesis and cancer development. | 25190221 |
| Hollings Cancer Center | Epigenetic Alterations | However, no significant association between miRNA-608 rs4919510 and the risk of HCC/HBV-associated HCC was found. | 25190221 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Prognostic significance of microRNA expression in completely resected lung adenocarcinoma and the associated response to erlotinib. | 25192889 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | In conclusion, lung adenocarcinoma patients with reduced miRNA-21 expression exhibit longer overall survival and a poor response rate to erlotinib. | 25192889 |
| Refractory Cytopenia of Childhood, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Data mining using a microRNA array database suggested that let-7d microRNA may be associated with renal cell carcinoma (RCC) malignant progression. | 25193015 |
| Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation gene-based models indicating independent poor outcome in prostate cancer. | 25193387 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation plays an important role in determining the biology of cancer but prognostic information is scanty. | 25193387 |
| Prostate Cancer Pathway, Cessation of life | Epigenetic Alterations | We assessed the potential of gene-specific DNA methylation changes to predict death from prostate cancer in a cohort of untreated men in the UK. | 25193387 |
| Colorectal Cancer Pathway, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Recently, microRNA-339-5p has been reported to be frequently down-regulated in colorectal cancer, and furthermore, its down-regulation is associated with poor prognosis in cancer patients, which strongly suggests a tumor suppressive function of microRNA-339-5p in colorectal cancer. | 25193859 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Furthermore, microRNA-339-5p inhibits the migration and invasion of colorectal cancer cells and the growth of colorectal xenograft tumors in a largely p53-dependent manner. | 25193859 |
| Colorectal Neoplasms, Neoplasms | Epigenetic Alterations | Our results highlighted an important role of microRNA-339-5p in suppression of colorectal tumorigenesis, and also revealed that regulating the p53 function is an important mechanism for microRNA-339-5p in tumor suppression. | 25193859 |
| Glioblastoma | Epigenetic Alterations | Epigenetic silencing of MGMT is associated with loss of MGMT activity and improved sensitivity to alkylating agents in glioblastomas. | 25194640 |
| ovarian neoplasm | Epigenetic Alterations | A polymorphism at miRNA-122-binding site in the IL-1a 3UTR is associated with risk of epithelial ovarian cancer. | 25195148 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Epigenetic markers for noninvasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting. | 25196065 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Since aberrant promoter hypermethylation of tumor suppressor genes (TSGs) is widely considered to be an important epigenetic change in early carcinogenesis, this study identified a panel of methylation markers for early detection of NPC and also assessed the clinical usefulness of these markers with noninvasive plasma specimens instead of biopsies. | 25196065 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in numerous biological and pathological processes including colorectal cancer (CRC). | 25197016 |
| Coronary Artery Disease | Epigenetic Alterations | Polymorphism in miRNA-1 target site and circulating miRNA-1 phenotype are associated with the decreased risk and prognosis of coronary artery disease. | 25197382 |
| Malignant Neoplasms | Epigenetic Alterations | Lin28B, a homologue of Lin28, represses biogenesis of let-7 microRNAs with a role in tumorigenesis and is considered a potential therapeutic target for various human cancers. | 25197381 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-133a has been proven downregulated in many human malignancies and correlated with tumor progression. | 25198665 |
| Coronary Artery Disease | Epigenetic Alterations | Altered serum microRNAs as novel diagnostic biomarkers for atypical coronary artery disease. | 25198728 |
| Inflammation, Fibrosis Assessment | Epigenetic Alterations | In addition, target gene prediction showed that these five altered miRNAs are involved in affecting various aspects of cardiac or vascular remodeling, especially in the pathway involving inflammation and fibrosis. | 25198728 |
| Arteriosclerosis, Coronary Arteriosclerosis | Epigenetic Alterations | Our findings indicate that the five altered serum miRNAs could be novel non-invasive biomarkers for ACAD and may also represent potential therapeutic targets for atherosclerosis and myocardial ischemia. | 25198728 |
| Stage II Colon Cancer AJCC v7 | Epigenetic Alterations | The prognostic value of microRNA-126 and microvessel density in patients with stage II colon cancer: results from a population cohort. | 25199818 |
| Malignant tumor of colon | Epigenetic Alterations | We analysed the prognostic value of two angiogenesis parameters, microRNA-126 (miRNA-126) and microvessel density (MVD), in a population based cohort of patients operated for stage II colon cancer. | 25199818 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Long non-coding RNAs expressed in pancreatic ductal adenocarcinoma and lncRNA BC008363 an independent prognostic factor in PDAC. | 25200694 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) play critical roles in the development and progression of ovarian cancer. | 25201063 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Notably, plasma levels of miR-195 were reduced in patients with abdominal aortic aneurysms suggesting that microRNAs might serve as a noninvasive biomarker of abdominal aortic aneurysms. | 25201911 |
| Neoplasms | Epigenetic Alterations | Histone deacetylase (HDAC) is well-known to be associated with tumorigenesis through epigenetic regulation and its inhibitors (HDACIs) induce differentiation and apoptosis of tumor cells. | 25202113 |
| Stomach Carcinoma | Epigenetic Alterations | Association between common genetic variants in pre-microRNAs and prognosis of advanced gastric cancer treated with chemotherapy. | 25202115 |
| Malignant Neoplasms | Epigenetic Alterations | Common single-nucleotide polymorphisms (SNPs) in pre-miRNAs (hsa-mir-196a2, hsa-mir-146a and hsa-mir-499) have been associated with various malignancies and their prognoses. | 25202115 |
| Degenerative polyarthritis | Epigenetic Alterations | Epigenetic differences in human cartilage between mild and severe OA. | 25212754 |
| Degenerative polyarthritis | Epigenetic Alterations | The development of osteoarthritis (OA) depends on genetic and environmental factors, which influence the biology of the chondrocyte via epigenetic regulation. | 25212754 |
| Malignant Neoplasms | Epigenetic Alterations | Changes in DNA methylation in peripheral blood could be associated with malignancy at early stage. | 25213452 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Circulating Epstein-Barr virus microRNAs miR-BART7 and miR-BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment. | 25213622 |
| Neoplasms | Epigenetic Alterations | NPC is an Epstein-Barr virus (EBV) associated tumor in which only a few viral proteins but more than 20 BamHI A rightward transcripts (BART) microRNAs are detected, at abundant levels. | 25213622 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | The epigenetic silencing of miR-23a led to derepression of BCR/ABL expression, and consequently contributes to CML development and progression. | 25213664 |
| Neoplasms | Epigenetic Alterations | MicroRNA (miR) 149 functions as a tumor suppressor and plays an important role in the carcinogenesis of renal cells. | 25213695 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-10b indicates a poor prognosis of non-small cell lung cancer and targets E-cadherin. | 25214146 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-10b(miR-10b) has been reported to be dysregulated in some types of cancer and to play an important role in invasion and metastasis. | 25214146 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Lung fibroblasts from patients with idiopathic pulmonary fibrosis exhibit genome-wide differences in DNA methylation compared to fibroblasts from nonfibrotic lung. | 25215577 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | DNA methylation changes are critical to the development of many diseases, but the DNA methylome of IPF fibroblasts has never been characterized. | 25215577 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | DNA methylation differences may thus help to explain a proportion of the differences in gene expression previously observed in studies of IPF fibroblasts. | 25215577 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Moreover, significant variability in DNA methylation was observed among individual IPF cell lines, suggesting that differences in DNA methylation may contribute to fibroblast heterogeneity among patients with IPF. | 25215577 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | These results demonstrate that IPF fibroblasts exhibit global differences in DNA methylation that may contribute to the excessive fibroproliferation associated with this disease. | 25215577 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Plasma circulating-microRNA profiles are useful for assessing prognosis in patients with cytogenetically normal myelodysplastic syndromes. | 25216221 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | We applied a novel, high-throughput digital quantification technology (NanoString) to profile microRNA expression in plasma samples of 72 patients with myelodysplastic syndromes and 12 healthy individuals. | 25216221 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | In patients with myelodysplastic syndromes associated with a diploid karyotype, we identified and validated a 7-microRNA signature as an independent predictor of survival with a predictive power of 75% accuracy (P=0.008), better than those of the International Prognostic Scoring Systems and the MD Anderson Prognostic Lower Risk Prognostic Model. | 25216221 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | These results validate the utility of circulating-microRNA levels as noninvasive biomarkers that can inform the management of patients with myelodysplastic syndromes. | 25216221 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | We also identified differentially expressed plasma microRNAs in patients with myelodysplastic syndromes versus healthy individuals and between patients with myelodysplastic syndromes associated with different cytogenetic features. | 25216221 |
| Barrett Esophagus | Epigenetic Alterations | Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barretts esophagus carcinogenesis. | 25216530 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Dysregulation of miRNA expression plays an important role in cancer development, and circulating miRNAs are biomarkers of several cancers. | 25216866 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Elevated microRNA-185 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in clear cell renal cell carcinoma. | 25217984 |
| Neoplasms | Epigenetic Alterations | Tumors were classified as low or high miRNA-185-expressing using the median as the cutoff. | 25217984 |
| Neoplasms | Epigenetic Alterations | The median gene expression levels of VEGFR-2 were significantly lower in the tumors expressing low levels of miRNA-185, 0.31 (95 % CI, 0.25-0.37), compared to those expressing high levels of miRNA-185, 0.47 (95 % CI, 0.27-0.59), p = 0.02. | 25217984 |
| Neoplasms | Epigenetic Alterations | The median MVD was significantly lower in the tumors expressing low levels of miRNA-185, 6.8 (95 % CI, 6.33-7.67), compared to those expressing high levels, 8.0 (95 % CI, 6.33-9.00), p < 0.01. miRNA-185 was detected in endothelial cells by in situ hybridization detection. | 25217984 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | The results suggest that high levels of miRNA-185 in RCC are associated with high VEGFR-2 mRNA and protein levels and a higher density of microvessels. | 25217984 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | However, further investigation should be performed to analyze the prognostic value of miRNA-185 in RCC. | 25217984 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in a number of biological processes, including tumor biology. | 25217984 |
| Vulvar Neoplasms | Epigenetic Alterations | HPV16 DNA methylation, integration and gene expression were assessed using pyrosequencing, ligation-mediated PCR and QPCR, in biopsies from 25 patients attending a specialist vulval neoplasia clinic and in short-term clonal cell lines derived from vulval and vaginal neoplasia. | 25218242 |
| Human Papillomavirus Positive | Epigenetic Alterations | The data suggest that increased HPV DNA methylation may be partly attributable to viral integration, and provide a biological rationale for quantification of L1/L2 methylation in triage of HPV positive cervical screening samples. | 25218242 |
| Malignant neoplasm of stomach, Neoplasms | Epigenetic Alterations | MicroRNA-106b~25 expressions in tumor tissues and plasma of patients with gastric cancers. | 25218271 |
| Tetranitromethane, Metastasis, Neoplasms | Epigenetic Alterations | The expression of miRNA-106b~25 cluster in tumor tissues was significantly correlated with tumor size, borrmann type, depth of tumor invasion (T), lymph node metastases (N), distant metastasis (M) and TNM stage (P<0.05). | 25218271 |
| Tetranitromethane, Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Considering the relationship between three miRNAs and some clinical pathological factors (TNM stage), it was implied that miR-106b~25 could be the next potential tumor biomarker for diagnosis and predictive prognosis for gastric cancer patients. | 25218271 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Prognostic value of microRNA-100 in esophageal squamous cell carcinoma. | 25218280 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | MicroRNA-100 (miR-100) has been demonstrated to be implicated in tumorigenesis and tumor progression of human esophageal squamous cell carcinoma (ESCC). | 25218280 |
| Primary malignant neoplasm, Leukemia, Myelocytic, Acute | Epigenetic Alterations | In silico analysis of DNA methylation data for 173 AML samples generated by the Cancer Genome Atlas Research Network revealed promoter hypermethylation of the gene encoding Y box binding protein 3, YBX3, in 11/173 (6.4%) AML cases, which was significantly associated with reduced mRNA expression (P < 0.0001). | 25220401 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia. | 25220401 |
| Hematologic Neoplasms | Epigenetic Alterations | Although aberrant epigenetic changes are frequently implicated in blood cancers, their direct role in suppressing one or both alleles of critical splicing factors has not been previously examined. | 25220401 |
| Morular Metaplasia of the Endometrium | Epigenetic Alterations | Serum miRNA levels were analyzed in 108 newly diagnosed symptomatic MM patients and 56 healthy donors (HDs). | 25220540 |
| Primary malignant neoplasm | Epigenetic Alterations | It is increasingly apparent that cancer development depends not only on genetic alterations, but also on epigenetic changes involving histone modifications. | 25220908 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are thought to play a role in cancer development. | 25222224 |
| Malignant Neoplasms | Epigenetic Alterations | Polymorphisms in pri-, pre-, and mature-microRNAs (miRNAs) have been proposed to be associated with various human cancers. | 25222241 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic test for breast cancer. | 25225690 |
| Metastasis | Epigenetic Alterations | Thus, miR-506 represents a new class of miRNA that regulates both E-cad and vimentin/N-cad in the suppression of EMT and metastasis. | 25230372 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | miR-1285-3p acts as a potential tumor suppressor miRNA via downregulating JUN expression in hepatocellular carcinoma. | 25230788 |
| Osteopenia, Osteoporosis | Epigenetic Alterations | We have demonstrated that specific miRNAs species are significantly changed in the plasma of osteoporosis and osteopenia patients and correlated with the BMD. | 25231354 |
| Primary malignant neoplasm | Epigenetic Alterations | Emerging evidence suggests that altered expression of microRNAs (miRNAs) is involved in cancer progression. | 25231560 |
| Ulcerative Colitis | Epigenetic Alterations | The identification of differentially expressed miRNAs, IL-37, and IRAK-M suggests different pathophysiologic mechanisms in various disease stages in LC, CC, and UC. | 25232259 |
| Colorectal Traditional Serrated Adenoma | Epigenetic Alterations | MicroRNA-31 expression in colorectal serrated pathway progression. | 25232271 |
| Clinical Coordinator | Epigenetic Alterations | We have recently observed that microRNA-31 (miR-31) expression is associated with BRAF mutation and prognosis in CRC. | 25232271 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers (CRC). | 25232271 |
| Colorectal Carcinoma | Epigenetic Alterations | microRNA-221 and microRNA-18a identification in stool as potential biomarkers for the non-invasive diagnosis of colorectal carcinoma. | 25233396 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | The detection of microRNA (miRNA) dysregulation in stool is a novel approach for the diagnosis of colorectal carcinoma (CRC). | 25233396 |
| Clinical Coordinator | Epigenetic Alterations | A miRNA expression array containing 667 miRNAs was performed to identify miRNA dysregulation in CRC tissues. | 25233396 |
| Clinical Coordinator | Epigenetic Alterations | We focused on miR-221 and miR-18a, two significantly upregulated miRNAs which were subsequently verified in 40 pairs of CRC tissues and 595 stool samples (198 CRCs, 199 polyps and 198 normal controls). | 25233396 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-196 (miR-196), which is highly up-regulated in oral cancer cells, has been reported to be aberrantly expressed in several cancers; however, the significance of miR-196 in oral cancer has not yet been addressed. | 25233933 |
| Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease, Myelofibrosis | Epigenetic Alterations | Overexpression of high mobility group AT-hook 2 (Hmga2), which is negatively regulated by MIRLET7 micro RNAs through 3-untranslated region (3UTR), causes proliferative haematopoiesis mimicking myeloproliferative neoplasms (MPNs) and contributes to progression of myelofibrosis in mice. | 25236537 |
| Primary malignant neoplasm | Epigenetic Alterations | The targets of four down-regulated miRNAs in MPM (mir-181a-5p, miR-101-3p, miR-145-5p and miR-212-3p), one in PP (mir-101-3p) and one in HP (mir-494) were significantly enriched in "pathways in cancer". | 25236577 |
| Serous Cystadenocarcinoma, Adenocarcinoma, Clear Cell | Epigenetic Alterations | To identify microRNA profiles specific for clear cell carcinomas, microRNA expression profiles were compared between clear cell carcinomas and serous carcinomas of the ovary using microRNA microarray. | 25238166 |
| Adenocarcinoma, Clear Cell, Neoplasms | Epigenetic Alterations | When germ cell tumors were compared with clear cell carcinomas of the ovary, miR-302d was the most significantly overexpressed microRNA in germ cell tumors. | 25238166 |
| Endometrial Clear Cell Adenocarcinoma | Epigenetic Alterations | Thus, here we describe microRNA profiles characteristic for clear cell carcinomas of the ovary and uterus. | 25238166 |
| Ovarian Clear Cell Tumor, Serous Cystadenocarcinoma, Adenocarcinoma, Clear Cell, Carcinoma, Endometrioid | Epigenetic Alterations | Six microRNAs differentially expressed between ovarian clear cell and serous carcinomas distinguished uterine clear cell carcinomas from endometrioid carcinomas. | 25238166 |
| Inflammation | Epigenetic Alterations | Differential expression and correlations between miRNAs, genes of the TLR pathways, and clinical parameters are unique findings in the severely injured and may lead to a greater understanding of the regulation of sterile inflammation after severe injury. | 25239329 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Clinical potential role of circulating microRNAs in early diagnosis of colorectal cancer patients. | 25239640 |
| Clinical Coordinator | Epigenetic Alterations | Circulating microRNAs (miRNAs) are promising molecular markers for CRC prediction. | 25239640 |
| Clinical Coordinator | Epigenetic Alterations | We performed a comprehensive meta-analysis to integrate an evaluation index for diagnostic accuracy of circulating miRNAs in diagnosing CRC patients. | 25239640 |
| Insulator | Epigenetic Alterations | Subsequent investigations indicate that long intergenic non-coding RNA lincRNA-NR_034037, separating TSNAX from DISC1, regulates TSNAX -DISC1 production and TSNAX/DISC1 expression levels by extricating CTCF from insulators. | 25239642 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | The deregulation of microRNAs has been reported to play a pivotal role in hepatocellular carcinoma (HCC). | 25240815 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Ubiquitin-specific protease 22 (USP22) is a component of the transcription regulatory histone acetylation complex SAGA, which broadly regulates gene transcription and correlates with cancer progression, metastasis and prognosis. | 25241857 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) are novel transcripts that may play important roles in cancer. | 25243407 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Prognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer. | 25243792 |
| Neoplasms | Epigenetic Alterations | Numerous changes in epigenetic mechanisms have been described in various types of tumors. | 25243792 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic inactivation and tumor-suppressor behavior of NGFR in human colorectal cancer. | 25244921 |
| Blood Clot | Epigenetic Alterations | A panel of microRNAs as a new biomarkers for the detection of deep vein thrombosis. | 25244974 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | microRNA-548l is involved in the migration and invasion of non-small cell lung cancer by targeting the AKT1 signaling pathway. | 25245053 |
| Primary malignant neoplasm | Epigenetic Alterations | microRNAs (miRNAs) have been documented playing a critical role in cancer development and progression. | 25245053 |
| Primary malignant neoplasm | Epigenetic Alterations | Several miRNAs are differentially expressed in cancer and many are being considered as biomarkers for predicting clinical outcomes. | 25252191 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The expression of microRNA-375 in plasma and tissue is matched in human colorectal cancer. | 25255814 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) offer great potential as cancer biomarkers. | 25255814 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | The importance of miRNAs profiling in tissue and body fluids in colorectal cancer (CRC) have been addressed respectively in many studies. | 25255814 |
| Cardiovascular Diseases | Epigenetic Alterations | MicroRNAs (miRNAs) are associated with cardiovascular disease and control gene expression and are detectable in the circulation. | 25257092 |
| Neoplasms, Leukemia, Myelocytic, Acute | Epigenetic Alterations | SMG1 acts as a novel potential tumor suppressor with epigenetic inactivation in acute myeloid leukemia. | 25257528 |
| Neoplasms, Leukemia, Myelocytic, Acute | Epigenetic Alterations | In conclusion, our results indicate that SMG1 acts as a potential tumor suppressor with epigenetic regulation in AML. | 25257528 |
| Neoplasms | Epigenetic Alterations | At the molecular level, non-coding RNAs and especially microRNAs have played an important role in the origin and development of this neoplasm In the Anglo-Saxon population, diverse genetic variants in microRNA genes and in their targets are associated with the development of this disease. | 25259427 |
| Breast Carcinoma | Epigenetic Alterations | [Genetic variants in miRNAs and its association with breast cancer]. | 25259427 |
| Stomach Carcinoma | Epigenetic Alterations | The novel long noncoding RNA AC138128.1 may be a predictive biomarker in gastric cancer. | 25260808 |
| Carcinogenesis | Epigenetic Alterations | It is well known that the differential expression of long noncoding RNA (lncRNA) plays critical roles in carcinogenesis. | 25260808 |
| Primary malignant neoplasm | Epigenetic Alterations | Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer. | 25261372 |
| Primary malignant neoplasm | Epigenetic Alterations | Expression of miR-155 was detected and quantitated in rectal cancer tissues and in adjacent nonmalignant tissues from 40 patients by TaqMan MicroRNA assays. | 25261908 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently identified class of microRNAs (miRNAs) provided a new insight in cancer research. | 25261908 |
| Neoplasms | Epigenetic Alterations | As a member of miRNAs family, miR-155 expression demonstrated the correlation with tumor stage. | 25261908 |
| Primary malignant neoplasm | Epigenetic Alterations | Enhancer of zeste homolog 2 (EZH2) plays a key role in tumorigenesis and cancer progression through epigenetic gene silencing and chromatin remodeling. | 25262426 |
| Radiation-Induced Cancer | Epigenetic Alterations | Radiation-induced changes in DNA methylation and their relationship to chromosome aberrations in nuclear power plant workers. | 25264146 |
| Carcinoma, Adrenal Cortical Adenoma | Epigenetic Alterations | Specific MicroRNAs Differentiate Adrenocortical Adenomas from Carcinomas and Correlate With Weiss Histopathologic System. | 25265426 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRs) play a central role in regulating gene expression and are strongly associated with cancer development. | 25265426 |
| Septicemia | Epigenetic Alterations | Dysregulation in microRNA expression in peripheral blood mononuclear cells of sepsis patients is associated with immunopathology. | 25265569 |
| Kaposi Sarcoma | Epigenetic Alterations | The expression profiles of microRNAs in Kaposis sarcoma. | 25266797 |
| Cessation of life | Epigenetic Alterations | MicroRNAs are non-protein-coding small RNAs in the size range 19-25 nucleotides (nt) that play important roles in biological processes, including cellular differentiation, proliferation, and death. | 25266797 |
| Squamous cell carcinoma | Epigenetic Alterations | Expression of microRNA-10a-5p was down-regulated in LEPL, showing statistical difference between low-risk lesion group and high-risk lesion group, while microRNA-34c-5p expression was up-regulated gradually in LEPL groups and dropped suddenly in squamous cell carcinoma group. | 25266939 |
| Malignant Neoplasms | Epigenetic Alterations | Dysregulation of microRNA plays critical roles in various malignancies. | 25270284 |
| Liver neoplasms | Epigenetic Alterations | In summary, a senescence-inducing program was found in hepatocytes with increased b-catenin levels and a positive selection of hepatocytes lacking p16(INK4a), by epigenetic silencing, drives the development of liver tumors in mice with reduced APC expression (Apc(580S) mice). | 25270420 |
| Liver neoplasms | Epigenetic Alterations | Epigenetic silencing of p16(Ink4a) in selected liver cells bypassing senescence is a general principle for development of liver tumors with b-catenin involvement in mice independent of the initial stimulus. | 25270420 |
| Breast Cancer Cell | Epigenetic Alterations | Upregulation of miRNA-494 (miR-494) has been identified as an oncogenic miRNA and is associated with poor prognosis in several types of human cancer. | 25270723 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidence has shown that micro-RNAs (miRNAs) are involved in multiple processes in cancer development and progression. | 25270723 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic silencing of miRNA-9 is correlated with promoter-proximal CpG island hypermethylation in gastric cancer in vitro and in vivo. | 25270964 |
| Neoplasms | Epigenetic Alterations | Here, we examine if tumor suppressor microRNAs (miRNAs) are silenced in a similar manner. | 25270964 |
| Carcinoma, Metastasis | Epigenetic Alterations | Three other miRNAs, miR-19b, miR-433, and miR-370 were associated with lymph node metastasis, decreased curvature, and poorly differentiated carcinoma. | 25270964 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Upregulated UHRF1 promotes bladder cancer cell invasion by epigenetic silencing of KiSS1. | 25272010 |
| Primary malignant neoplasm | Epigenetic Alterations | Ubiquitin-like with PHD and RING finger domains 1 (UHRF1), as an epigenetic regulator, plays important roles in the tumorigenesis and cancer progression. | 25272010 |
| Malignant Neoplasms, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | KiSS1 functions as a metastasis suppressor in various cancers, and epigenetic silencing of KiSS1 increases the metastatic potential of cancer cells. | 25272010 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | These data demonstrated that upregulated UHRF1 increases bladder cancer cell invasion by epigenetic silencing of KiSS1. | 25272010 |
| Primary malignant neoplasm | Epigenetic Alterations | Altogether, our data indicate that epigenetic activation of rDNA genes induced by JHDM1B depletion is associated with a p53-dependent growth arrest, but may promote cancer cell growth when p53 is lacking. | 25273595 |
| Breast Carcinoma | Epigenetic Alterations | Wild-type genotypes of BRCA1 gene SNPs combined with micro-RNA over-expression in mammary tissue leading to familial breast cancer with an increased risk of distant metastases occurrence. | 25273865 |
| Stomach Carcinoma | Epigenetic Alterations | DNA methylation at selected CpG sites in peripheral blood leukocytes is predictive of gastric cancer. | 25275032 |
| Neoplasm Metastasis | Epigenetic Alterations | MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in post-transcriptional gene regulation and have recently been shown to play a role in cancer metastasis. | 25277099 |
| Secondary malignant neoplasm of female breast | Epigenetic Alterations | MicroRNA expression as risk biomarker of breast cancer metastasis: a pilot retrospective case-cohort study. | 25277099 |
| Breast Carcinoma, Metastasis, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | In solid tumors, especially breast cancer, alterations in miRNA expression contribute to cancer pathogenesis, including metastasis. | 25277099 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | Considering the emerging role of miRNAs in metastasis, the identification of predictive markers is necessary to further the understanding of stage-specific breast cancer development. | 25277099 |
| Metastasis | Epigenetic Alterations | Among these, we identified miRNAs previously associated with cell motility (let-7 family) and distant metastasis (hsa-miR-21). | 25277099 |
| MIR183 wt Allele | Epigenetic Alterations | Between them, hsa-miR-183 was the most significative of CSII, which miRNAs combination for CSII (hsa-miR-494, hsa-miR-183 and hsa-miR-21) was significant and were a more effective risk marker compared to the single miRNAs. | 25277099 |
| Secondary malignant neoplasm of female breast | Epigenetic Alterations | These miRNAs therefore represent new risk biomarkers of breast cancer metastasis and may be useful for future targeted therapies. | 25277099 |
| Carcinoma of lung, Adenocarcinoma | Epigenetic Alterations | Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome. | 25278450 |
| Carcinoma of lung | Epigenetic Alterations | However, whether clinically relevant subgroups based on DNA methylation patterns exist in lung cancer remains unclear. | 25278450 |
| Adenocarcinoma | Epigenetic Alterations | Unsupervised bootstrap clustering was performed to identify DNA methylation subgroups, which were validated in 695 adenocarcinomas and 122 SqCCs. | 25278450 |
| Carcinoma of lung, Adenocarcinoma, Neoplasms | Epigenetic Alterations | This study demonstrates the possibility to further subgroup lung cancer, and more specifically adenocarcinomas, based on epigenetic/molecular classification that could lead to more accurate tumor classification, prognostication, and tailored patient therapy. | 25278450 |
| Glioma | Epigenetic Alterations | A miRNA signature for defining aggressive phenotype and prognosis in gliomas. | 25279461 |
| Colonic Neoplasms | Epigenetic Alterations | The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas (TCGA) datasets. | 25279461 |
| Glioma, Neoplasms | Epigenetic Alterations | We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours. | 25279461 |
| Glioblastoma, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | 25279461 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis. | 25280565 |
| Somatic, ovarian neoplasm, BRCA1 gene | Epigenetic Alterations | The performance of BRCA1 immunohistochemistry for detecting germline, somatic, and epigenetic BRCA1 loss in high-grade serous ovarian cancer. | 25281711 |
| ovarian neoplasm, BRCA1 gene | Epigenetic Alterations | Given the potential importance of BRCA1 loss as a predictive and prognostic biomarker in high-grade serous ovarian cancer, we sought to evaluate the utility of BRCA1 immunohistochemistry (IHC) in screening for BRCA1 loss by germline, somatic, and epigenetic mechanisms. | 25281711 |
| Somatic, BRCA1 gene | Epigenetic Alterations | BRCA1 IHC interpretation was a highly reproducible and accurate modality for detecting germline, somatic, or epigenetic mechanisms of BRCA1 loss. | 25281711 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Gene promoter hypermethylation is recognised as an essential early step in carcinogenesis, indicating important application areas for DNA methylation analysis in early cancer detection. | 25281766 |
| Malignant neoplasm of endometrium, cervical cancer, Histologic type | Epigenetic Alterations | All samples of women with cervical cancer (79/79, 100%), independent of the histotype, and 76% (16/21; 95% CI 58.0% to 94.4%) of women with endometrial cancer scored positive for DNA methylation for at least one of the three genes. | 25281766 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9. | 25281924 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | miR-3127-5p is a primate-specific miRNA which is down-regulated in recurrent NSCLC tissue vs. matched primary tumor tissue (N = 15) and in tumor tissue vs. normal lung tissue (N = 177). | 25284075 |
| palladium, Parkinson Disease | Epigenetic Alterations | The deregulation of several microRNAs (miRNAs) has been associated with neurodegenerative processes, including Parkinsons disease (PD). | 25284245 |
| Clinical Coordinator, Adenoma | Epigenetic Alterations | We selected 7 miRNA candidates with previously reported elevated expression in adenoma tissue but low expression in blood cells ("rare" miRNAs), 2 previously proposed as adenoma biomarkers, and 3 implicated in CRC. | 25286412 |
| Clinical Coordinator | Epigenetic Alterations | Strong (ORs >5) and significant associations with CRC were observed for 6 miRNA candidates, with corresponding AUCs significantly >0.5. | 25286412 |
| Colorectal Neoplasms | Epigenetic Alterations | Rare circulating microRNAs as biomarkers of colorectal neoplasia. | 25286412 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNAs (miRNAs) are regulatory RNAs, stable in circulation, and implicated in colorectal cancer (CRC) etiology and progression. | 25286412 |
| Colorectal Neoplasms | Epigenetic Alterations | However, many circulating miRNAs are highly expressed in blood cells, and therefore may not be specific to colorectal neoplasia. | 25286412 |
| Adenoma | Epigenetic Alterations | No miRNAs were significantly associated with non-advanced or advanced adenomas. | 25286412 |
| Adenoma | Epigenetic Alterations | These candidate miRNAs, assayed by qRT-PCR, are probably unsuitable as blood-based adenoma biomarkers. | 25286412 |
| Clinical Coordinator | Epigenetic Alterations | Strong associations between miRNAs and CRC were observed, but primarily with miRNAs highly expressed in blood cells. | 25286412 |
| Adenoma | Epigenetic Alterations | These results suggest that rare miRNAs will require new detection methods to serve as circulating biomarkers of adenomas. | 25286412 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival. | 25287138 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | However, the role of DNA methylation in breast cancer development and progression and its relationship with the intrinsic tumor subtypes are not fully understood. | 25287138 |
| Neoplasms | Epigenetic Alterations | This study demonstrates that epigenetic patterns are strongly associated with HR status, subtype, and p53 mutation status and may show heterogeneity within tumor subclass. | 25287138 |
| Acute Cerebrovascular Accidents | Epigenetic Alterations | Circulating microRNAs as novel potential biomarkers for early diagnosis of acute stroke in humans. | 25287657 |
| Acute Cerebrovascular Accidents | Epigenetic Alterations | The significance of circulating miRNAs for early diagnosis of acute stroke in humans is unknown. | 25287657 |
| MIR106B gene, Acute Cerebrovascular Accidents | Epigenetic Alterations | Compared with healthy individuals, the miRNAs were increased as in patients with acute stroke as follows: hsa-miR-106b-5P, 3.63-fold in MRI(-) patients and 23.90-fold in MRI(+) patients; hsa-miR-4306, 3.19-fold in MRI(-) patients and 5.30-fold in MRI(+) patients; hsa-miR-320e, .33-fold in MRI(-) patients and .13-fold in MRI(+) patients; and hsa-miR-320d, .23-fold in MRI(-) patients and .07-fold in MRI(+) patients. | 25287657 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Genome-wide miRNA profiling in myelodysplastic syndrome with del(5q) treated with lenalidomide. | 25287904 |
| SF3B1 wt Allele | Epigenetic Alterations | This report describes changes in miRNA expression in del(5q) patients with MDS treated with lenalidomide, likely arising from deregulation of pathways implicated in lenalidomide action. | 25287904 |
| Haploinsufficiency | Epigenetic Alterations | Additionally, we focused more deeply on miRNAs from the 5q commonly deleted region and found that levels of miR-378 and miR-378* followed haploinsufficiency trend. | 25287904 |
| Pituitary Neoplasms, Metastasis | Epigenetic Alterations | However, the molecular mechanism of these miRNAs in pituitary tumor growth and metastasis is still unclear. | 25305447 |
| Pituitary Neoplasms | Epigenetic Alterations | Then, we show that these miRNAs synergistically target Sox5 in pituitary tumor. | 25305447 |
| Pituitary Neoplasms, Neoplasms | Epigenetic Alterations | In conclusion, our data indicate that miR-132 and miR-15a/16 act as tumor suppressor genes in pituitary tumor by directly targetting Sox5, and imply that these miRNAs have potential as therapeutic targets for invasive pituitary tumor. | 25305447 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer. | 25307864 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic changes are of crucial importance in cancer development and are potentially reversible; they are therefore targets of interest for anti-cancer therapy. | 25307864 |
| Colorectal Neoplasms | Epigenetic Alterations | The epigenetic markers were immunohistochemically stained on tissue microarrays containing colorectal tumours (n = 254) and normal colorectal tissues (n = 50). | 25307864 |
| Carcinogenesis | Epigenetic Alterations | These results indicate that epigenetic mechanisms play an important role in colorectal carcinogenesis. | 25307864 |
| Laryngeal Squamous Cell Carcinoma | Epigenetic Alterations | MicroRNA-93 regulates cyclin G2 expression and plays an oncogenic role in laryngeal squamous cell carcinoma. | 25309979 |
| Weight decreased, Obesity, Malignant neoplasm of liver | Epigenetic Alterations | The epigenetic age acceleration, which is not reversible in the short term after rapid weight loss induced by bariatric surgery, may play a role in liver-related comorbidities of obesity, such as insulin resistance and liver cancer. | 25313081 |
| Malignant tumor of colon, Metastasis | Epigenetic Alterations | MicroRNA classifier and nomogram for metastasis prediction in colon cancer. | 25315964 |
| Malignant tumor of colon | Epigenetic Alterations | In addition, we recommend combination of miR16-5p and miR26a-5p as standard for normalization in qPCR of colon cancer tissue-derived miRNA expression. | 25315964 |
| Tetranitromethane, Neoplasms | Epigenetic Alterations | In conjunction with TNM staging, by means of a nomogram, this miRNA classifier may allow for personalized treatment decisions based on individual tumor characteristics. | 25315964 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNAs have been proposed as potential biomarkers for cancer. | 25315964 |
| Neoplasms | Epigenetic Alterations | MicroRNA-224 is downregulated in mucinous cystic neoplasms of the pancreas and may regulate tumorigenesis by targeting Jagged1. | 25322937 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | An miRNA array identified miRNA expression level changes in response to NRF2 knockdown in AML cells. | 25323587 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Posttranscriptional regulation by microRNAs (miRNAs) can affect the malignant phenotype of AML cells. | 25323587 |
| Bladder Neoplasm | Epigenetic Alterations | DNA methylation analysis showed tumor-specific TGS2 promoter methylation in 73% (38/52) of bladder tumors. | 25323766 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Epigenetic repression of regulator of G-protein signaling 2 by ubiquitin-like with PHD and ring-finger domain 1 promotes bladder cancer progression. | 25323766 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | However, little is known about whether UHRF1 promotes bladder cancer progression by epigenetic silencing of RGS2. | 25323766 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | These results demonstrate that epigenetic repression of RGS2 by UHRF1 contributes to bladder cancer progression. | 25323766 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Cancer is a consequence of accumulation of genetic and epigenetic alterations in the cell which can lead to activation of oncogenes or inactivation of tumor suppressor genes (TSG). | 25324173 |
| Toxicity aspects | Epigenetic Alterations | Arsenic is associated with a number of health outcomes, with epigenetic modification suggested as a potential mechanism of toxicity. | 25325195 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Long noncoding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer. | 25326054 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Tissue microRNAs as predictors of outcome in patients with metastatic colorectal cancer treated with first line Capecitabine and Oxaliplatin with or without Bevacizumab. | 25329796 |
| Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | We tested the hypothesis that expression of microRNAs (miRNAs) in cancer tissue can predict effectiveness of bevacizumab added to capecitabine and oxaliplatin (CAPEOX) in patients with metastatic colorectal cancer (mCRC). | 25329796 |
| Breast Carcinoma, Ductal Carcinoma, Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | DNA methylation is a well-studied biomarker in invasive breast cancer, but its role in ductal carcinoma in situ (DCIS) is less well characterized. | 25331261 |
| Primary malignant neoplasm | Epigenetic Alterations | SHOX2 DNA methylation identified 66% of the patients with cancer subsequent to a cytological equivocal diagnosis. | 25331797 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes. | 25332168 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | The CpG island methylator phenotype (CIMP) of clear cell renal cell carcinomas (ccRCCs) is characterized by accumulation of DNA methylation at CpG islands and poorer patient outcome. | 25332168 |
| Breast Carcinoma | Epigenetic Alterations | Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients. | 25333260 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs were additionally quantified in exosomes of 50 cancer patients and 12 healthy women from the same cohort. | 25333260 |
| Carcinogenesis | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) play a key role in cellular processes, such as cell growth, apoptosis, and carcinogenesis. | 25337221 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNA-218 (miR-218) acts as a tumor suppressor in numerous types of cancer by regulation of the expression of target genes. | 25337271 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Because 3 untranslated region (3UTR) polymorphisms disrupting microRNA (miRNA) binding can be functional and can act as genetic markers of cancer risk, we aimed to determine genetic variation in the 3UTR of BRCA1/BRCA2 in familial and early-onset breast cancer patients with and without mutations in the coding regions of BRCA1/ BRCA2 and to identify specific 3UTR variants that may be risk factors for cancer development. | 25339023 |
| Early-onset, Breast Carcinoma | Epigenetic Alterations | Evaluation of genetic variations in miRNA-binding sites of BRCA1 and BRCA2 genes as risk factors for the development of early-onset and/or familial breast cancer. | 25339023 |
| Ductal Carcinoma | Epigenetic Alterations | Expression of DNA methylation marker of paired-like homeodomain transcription factor 2 and growth receptors in invasive ductal carcinoma of the breast. | 25339043 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology. | 25342220 |
| Carcinoma of lung | Epigenetic Alterations | We conclude that miRNAs disrupted in a smoking status-dependent manner affect distinct cellular pathways and differentially influence lung cancer patient prognosis in current, former and never smokers. | 25342220 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA library-based functional screening identified miR-137 as a suppresser of gastric cancer cell proliferation. | 25342326 |
| Stomach Carcinoma | Epigenetic Alterations | miRNA mimics were transfected into gastric cancer cell line SGC7901 and the effect of individual miRNA on the proliferation rate of the cells was measured by the RT-CES system. | 25342326 |
| Malignant Neoplasms | Epigenetic Alterations | miRNAs has been suggested to play a crucial role in the pathogenesis and development of various cancers. | 25342326 |
| Primary malignant neoplasm | Epigenetic Alterations | Genetic variation in miRNA-encoding sequences or their corresponding binding sites may affect the fidelity of the miRNA-mRNA interaction and subsequently alter the risk of cancer development. | 25342389 |
| Admitting diagnosis | Epigenetic Alterations | These data suggest that an exosomal miRNA signature may have potential to be developed as a suitable peripheral screening tool for AD. | 25349172 |
| Coronary Artery Disease | Epigenetic Alterations | MicroRNA expression in circulating microvesicles predicts cardiovascular events in patients with coronary artery disease. | 25349183 |
| Malignant Neoplasms, Lymphoma | Epigenetic Alterations | The methylation of DNA at position 5 of cytosine, and the subsequent reduction in intracellular 5-hydroxymethylcytosine (5-hmC) levels, is a key epigenetic event in several cancers, including systemic lymphomas. | 25353265 |
| Neoplasms | Epigenetic Alterations | PSD gene may function as a tumor suppressor in GC suggesting a vital role for DNA methylation and histone modification in PSD silencing. | 25355626 |
| Stomach Carcinoma | Epigenetic Alterations | The Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance. | 25355626 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | Upregulation of microRNA-31 associates with a poor prognosis of malignant pleural mesothelioma with sarcomatoid component. | 25358615 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells. | 25361001 |
| Clinical Coordinator | Epigenetic Alterations | Aberrant microRNA expression holds great potential as diagnostic and prognostic biomarker for CRC. | 25362853 |
| Alzheimers Disease | Epigenetic Alterations | Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease. | 25365775 |
| Admitting diagnosis | Epigenetic Alterations | Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 was associated with pathological AD. | 25365775 |
| Pathology | Epigenetic Alterations | Brain DNA methylation in multiple AD loci is associated with AD pathologies. | 25365775 |
| Admitting diagnosis | Epigenetic Alterations | The results provide further evidence that disruption of DNA methylation is involved in the pathological process of AD. | 25365775 |
| Sarcoidosis, Pulmonary | Epigenetic Alterations | Differential inflammatory microRNA and cytokine expression in pulmonary sarcoidosis. | 25366387 |
| Autoimmune reaction | Epigenetic Alterations | Accordingly, changes in the expression of some miRNAs have been also associated with different autoimmune pathologies. | 25366387 |
| Malignant tumor of colon | Epigenetic Alterations | Importantly, the relationship between DNA methylation of PKCB and gene expression may warrant further attention in the context of colon cancer chemoprevention and anti-cancer therapy. | 25366420 |
| Clear cell adenocarcinoma of ovary | Epigenetic Alterations | MicroRNA-21 is a candidate driver gene for 17q23-25 amplification in ovarian clear cell carcinoma. | 25366985 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant expression of microRNAs has been shown to be involved in oncogenesis, and microRNA-21 (miR-21) is frequently overexpressed in many types of cancers. | 25366985 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | However, there was no report on the correlation of genome-wide DNA methylation with survival benefit from chemotherapy in NSCLC. | 25367137 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Using the sandwich ELISA method, we found that the genome-wide DNA methylation level in NSCLC cancer tissues was significantly lower than that in adjacent normal tissues, which further validated the assay. | 25367137 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) are small noncoding RNAs, which are involved in a great variety of pathological processes, particularly carcinogenesis. | 25367852 |
| Stomach Carcinoma | Epigenetic Alterations | Three dysregulated microRNAs in serum as novel biomarkers for gastric cancer screening. | 25367852 |
| Primary malignant neoplasm | Epigenetic Alterations | MiRNAs are stable in gastric juice, plasma as well as serum, which facilitate it to be a promising biomarker for cancer. | 25367852 |
| Tetranitromethane, Neoplasms | Epigenetic Alterations | Relative expression of these miRNAs was significantly correlated with clinical characteristics of GC patients, such as TNM stage (P = 0.036 for miR-223; P < 0.001 for miR-100), metastatic status (P = 0.045 for miR-223; P = 0.031 for miR-16; P = 0.006 for miR-100), tumor size (P = 0.042 for miR-223; P = 0.031 for miR-16; P < 0.001 for miR-100), and differentiation grade (P = 0.036 for miR-223; P = 0.030 for miR-16; P = 0.034 for miR-100). | 25367852 |
| Primary malignant neoplasm | Epigenetic Alterations | Significantly elevated expression of the three miRNAs was also observed in advanced GC patients, which suggested their availability in cancer staging. | 25367852 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Tumor suppressor gene silencing through DNA methylation contributes to cancer formation. | 25367851 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Identification and Evaluation of Serum MicroRNA-29 Family for Glioma Screening. | 25367878 |
| Malignant Neoplasms | Epigenetic Alterations | Considering the fact that miRNAs are stable in serum, plasma, urine, and other body fluids, they show great promises to be convenient and non-invasive biomarkers for cancers. | 25367878 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients. | 25368035 |
| Chronic Obstructive Airway Disease, Abnormal breathing | Epigenetic Alterations | Epigenetic mechanisms in respiratory muscle dysfunction of patients with chronic obstructive pulmonary disease. | 25369292 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Epigenetic events are differentially expressed in the lungs and airways of patients with chronic obstructive pulmonary disease (COPD). | 25369292 |
| Functional disorder, Chronic Obstructive Airway Disease | Epigenetic Alterations | Moreover, epigenetic mechanisms are involved in the skeletal (peripheral) muscle dysfunction of COPD patients. | 25369292 |
| Chronic Obstructive Airway Disease, Abnormal breathing | Epigenetic Alterations | Whether epigenetic events may also regulate respiratory muscle dysfunction in COPD remains unknown. | 25369292 |
| Chronic Obstructive Airway Disease, Respiratory Muscles | Epigenetic Alterations | We hypothesized that epigenetic mechanisms would be differentially expressed in the main inspiratory muscle (diaphragm) of patients with COPD of a wide range of disease severity compared to healthy controls. | 25369292 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | It is likely that these epigenetic events act as biological adaptive mechanisms to better overcome the continuous inspiratory loads of the respiratory system in COPD. | 25369292 |
| Chronic Obstructive Airway Disease, Respiratory Muscles | Epigenetic Alterations | In the main respiratory muscle of COPD patients with a wide range of disease severity and normal body composition, muscle-specific microRNAs were downregulated, while HDAC4 and MEF2C levels were upregulated. | 25369292 |
| Multiple Myeloma | Epigenetic Alterations | The pathogenesis of multiple myeloma involves complex genetic and epigenetic events. | 25369863 |
| Multiple Myeloma | Epigenetic Alterations | MALAT1 long non-coding RNA is overexpressed in multiple myeloma and may serve as a marker to predict disease progression. | 25369863 |
| Prostate Cancer Pathway | Epigenetic Alterations | Heterogeneity of DNA methylation in multifocal prostate cancer. | 25369892 |
| Neoplasms | Epigenetic Alterations | Common epigenetic profile of recurrent tumors can be inferred from our data. | 25369892 |
| diabetic | Epigenetic Alterations | Insulin-stimulated glucose uptake is decreased in differentiated diabetic cultured myotubes, which is in keeping with a retained genetic/epigenetic defect of insulin action. | 25370850 |
| Malignant tumor of colon | Epigenetic Alterations | MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells. | 25371200 |
| Malignant tumor of colon, methionine | Epigenetic Alterations | In this study, we systematically demonstrate that Ascl2 loss of function in colon cancer cells promotes MET by derepressing the expression of microRNA (miR)-200s (i.e. | 25371200 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | microRNA-338-3p functions as a tumor suppressor in human non-small-cell lung carcinoma and targets Ras-related protein 14. microRNAs (miRNAs) have been demonstrated to be important gene regulators with critical roles in diverse biological processes, including tumorigenesis. | 25374067 |
| Primary malignant neoplasm | Epigenetic Alterations | Of 72 paired samples, 65 cancer tissues overexpressed microRNA-200a greater than two fold in comparison with matched normal epithelium. | 25374174 |
| ovarian neoplasm | Epigenetic Alterations | Our findings support the notion that miR- 200a is an onco-microRNA for ovarian cancer, and elevation is a useful potential diagnostic indicator. | 25374174 |
| B-Cell Lymphomas | Epigenetic Alterations | MicroRNA profiling of low-grade and transformed nodal marginal zone lymphoma reveals a similar signature pattern distinct from diffuse large B cell lymphoma. | 25376122 |
| Hematologic Neoplasms | Epigenetic Alterations | Many hematologic malignancies exhibit distinct microRNA signatures. | 25376122 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | While microRNA signatures of low-grade and transformed NMZL did not differ significantly, several microRNAs were differentially expressed between transformed NMZL and DLBCL, hinting at molecularly distinct mechanisms of lymphomagenesis and indicating the biological disparity of transformed NMZL from DLBCL. | 25376122 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | In the light of the unresolved issue regarding the classification of marginal zone-derived transformed B-cell neoplasms, microRNAs may be a valuable aid in discriminating NMZL from DLBCL. | 25376122 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | Genome-wide profiling of DNA methylation and tumor progression in human hepatocellular carcinoma. | 25376281 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | To clarify the progression pattern of abnormal DNA methylation during the development of hepatocellular carcinoma (HCC) using a comprehensive methylation assay. | 25376281 |
| Neoplasms | Epigenetic Alterations | Altered DNA methylation patterns during tumor progression were also analyzed. | 25376281 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | DNA methylation-dependent transcriptional inactivation of tumor suppressor genes (TSGs) is critical for the pathogenesis of hepatocellular carcinoma (HCC). | 25376292 |
| Hollings Cancer Center | Epigenetic Alterations | We identified several potential TSGs that participate in transcription inactivation through epigenetic interactions in HCC. | 25376292 |
| Hollings Cancer Center | Epigenetic Alterations | The results of this study are important for the understanding of functionally important epigenetic alterations in HCC. | 25376292 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Differential expression of microRNAs and their target genes in non-small-cell lung cancer. | 25376560 |
| Carcinoma of lung | Epigenetic Alterations | There were significantly differentially expressed miRNAs and mRNAs between lung cancer and normal tissue. | 25376560 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Further investigation of miRNAs and their target genes is warranted to better understand NSCLC. | 25376560 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. | 25379950 |
| Primary malignant neoplasm | Epigenetic Alterations | Assessment of the degree of an epigenetic field defect is a promising cancer risk marker that takes account of life history. | 25379950 |
| Malignant Neoplasms | Epigenetic Alterations | Cell free circulating microRNAs (cfmiRNAs) have been recognized as robust and stable biomarkers of cancers. | 25381453 |
| Infection caused by Helicobacter pylori, Adenocarcinoma Of Esophagus | Epigenetic Alterations | Whole-miRNome profiling identifies prognostic serum miRNAs in esophageal adenocarcinoma: the influence of Helicobacter pylori infection status. | 25381453 |
| Disease | Epigenetic Alterations | Over the past several years, evidence emerged that microRNAs (miRNAs), a class of small non-coding RNA molecules regulating gene expression at posttranscriptional level, play an important role in cell functioning, as well as in human diseases. | 25384507 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Expression of miRNAs in non-small-cell lung carcinomas and their association with clinicopathological features. | 25384507 |
| Carcinoma of lung | Epigenetic Alterations | Detailed analysis revealed significant change in expression of miR-15a/16, miR-34a, miR-126, and miR-210 in NSCLC tumor samples indicating involvement of these miRNAs in lung cancer pathogenesis. | 25384507 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Several recent studies have revealed that microRNAs (miRNAs) have a role in carcinogenesis and cancer development, and that it is stably detectable in plasma/serum. | 25384963 |
| Blood Circulation | Epigenetic Alterations | The extracellular miRNAs circulate in the bloodstream and may serve as novel diagnostic and therapeutic biomarkers. | 25385173 |
| Degenerative polyarthritis | Epigenetic Alterations | Cotransfection of OA chondrocytes with miR-608 or miR-602 mimic inhibited reporter activity, and mutation of the miRNA seed sequences abolished the repression of reporter activity. | 25385442 |
| Degenerative polyarthritis | Epigenetic Alterations | Because interleukin-1b (IL-1b) has been implicated as a principal instigator of OA, we sought to determine whether IL-1b induces the expression of sonic HH (SHH) and its regulation by microRNAs (miRNAs) in human chondrocytes. | 25385442 |
| Carcinoma of lung | Epigenetic Alterations | Deregulation of serum microRNA expression is associated with cigarette smoking and lung cancer. | 25386559 |
| Malignant Neoplasms, Carcinoma of lung | Epigenetic Alterations | Circulating microRNAs (miRNAs) are considered potential biomarkers of various cancers, including lung cancer. | 25386559 |
| Carcinoma of lung | Epigenetic Alterations | In conclusion, our results indicate that changes in serum miRNAs are associated with cigarette smoking and lung cancer and that let-7i-3p and miR-154-5p are potential biomarkers of smoking-related lung cancer. | 25386559 |
| Bacterial sepsis | Epigenetic Alterations | Expression profile of MicroRNAs in gram-negative bacterial sepsis. | 25394245 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Long-chain non-coding RNAs (lncRNAs) have been shown to be involved in the development and progression of non-small cell lung cancer (NSCLC). | 25394782 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-224 and its target CAMKK2 synergistically influence tumor progression and patient prognosis in prostate cancer. | 25394900 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | We previously demonstrated that microRNA (miR)-224 expression was significantly reduced in human prostate cancer (PCa) tissues and predicted unfavorable prognosis in patients. | 25394900 |
| Neoplasms | Epigenetic Alterations | We previously demonstrated that constitutive activation of the Wnt signalling pathway by epigenetic silencing of secreted frizzled-related protein 4 (SFRP4) is observed in this tumour. | 25395299 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The present study implicates b-catenin promoter hypermethylation in the mechanism of epigenetic changes underlying NSCLC metastasis and progression, thus indicating the potential of b-catenin as a novel epigenetic target for the treatment of NSCLC patients. | 25396757 |
| leprosy vaccine | Epigenetic Alterations | Transcriptional changes that characterize the immune reactions of leprosy. | 25398459 |
| Sample Size Calculation | Epigenetic Alterations | SSc cases showed a distinct expression profile with 14/26 miRNA significantly decreased (false discovery rate < 0.05) and 5/26 increased compared with HC. | 25399392 |
| Lupus Erythematosus, Systemic, Sample Size Calculation, hydrocortisone | Epigenetic Alterations | A 21-miRNA classifier gave optimum accuracy (80%) for discriminating SSc from both HC and SLE. | 25399392 |
| hydrocortisone, Sample Size Calculation, Lupus Erythematosus, Systemic | Epigenetic Alterations | The discrimination between HC and SSc (95% accuracy) was strongly driven by miRNA of the 17 ~ 92 cluster and by miR-16, -223, and -638, while SLE and SSc differed mainly in the expression of miR-142-3p, -150, -223, and -638. | 25399392 |
| Lupus Erythematosus, Systemic, Sample Size Calculation, hydrocortisone | Epigenetic Alterations | Circulating miRNA profiles are characteristic for SSc compared with both HC and SLE cases. | 25399392 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma. | 25400770 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | Previous studies observed the downregulation of microRNA (miR)-195 in esophageal squamous cell carcinoma (ESCC) tissues, confirmed cell division cycle 42 (Cdc42) as one target gene of miR-195, and demonstrated that miR-195 may act as a tumor suppressor in ESCC by regulating Cdc42 expression. | 25400770 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Stromal expression of MiR-21 predicts biochemical failure in prostate cancer patients with Gleason score 6. microRNAs (miRNAs) are involved in various neoplastic diseases, including prostate cancer (PCs). | 25401698 |
| Malignant tumor of colon | Epigenetic Alterations | We quantified DNA methylation of mucin genes (MUC2, MUC5AC, MUC4) in colonic cancers and examined the association with clinicopathological characteristics and molecular (MSI, KRAS, BRAF, and TP53 mutations) features. | 25403854 |
| Lymphoma, T-Cell, Cutaneous | Epigenetic Alterations | MicroRNA expression profiling and DNA methylation signature for deregulated microRNA in cutaneous T-cell lymphoma. | 25405321 |
| Communicable Diseases, TSPYL2 wt Allele, Lymphoma, T-Cell, Cutaneous | Epigenetic Alterations | Supervised clustering confirmed a distinctive microRNA profile for cutaneous T-cell lymphoma (CTCL) with respect to ID. | 25405321 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs usually regulate gene expression negatively, and aberrant expression has been involved in the development of several types of cancers. | 25405321 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer. | 25405368 |
| Malignant Neoplasms | Epigenetic Alterations | Our recent studies of microRNA (miRNA) expression signatures revealed that the microRNA-23b/27b (miR-23b/27b) cluster is frequently downregulated in various types of human cancers. | 25405368 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Restoration of mature miR-23b or miR-27b miRNAs significantly inhibited cancer cell migration and invasion, suggesting that these clustered miRNAs function as tumor suppressors. | 25405368 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma. | 25405789 |
| Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, Neoplasms | Epigenetic Alterations | Aberrant expression of miRNA-451a (miR-451a) has previously been reported in tumors, however its role in renal cell carcinoma (RCC) is currently unknown. | 25405789 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Alterations in the expression of several long non-coding RNAs (lncRNAs) have been found in primary nasopharyngeal carcinoma (NPC). | 25406670 |
| Breast Carcinoma | Epigenetic Alterations | Aberrant DNA methylation is a key feature of breast carcinoma. | 25407397 |
| Breast Carcinoma | Epigenetic Alterations | Overall, the OR for breast cancer was 0.42 (95% CI 0.20-0.90) for the top versus bottom quartile of epigenome-wide DNA methylation and the OR for a one standard deviation increment was 0.69 (95% CI 0.50-0.95; test for linear trend, p = 0.02). | 25407397 |
| protein expression, Type 2 | Epigenetic Alterations | MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion. | 25408296 |
| Communicable Diseases, Carcinogenesis | Epigenetic Alterations | MicroRNA polymorphisms may be associated with carcinogenesis or immunopathogenesis of infection. | 25408584 |
| Prostate Cancer Pathway | Epigenetic Alterations | In summary, miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers. | 25409297 |
| Ischemic stroke | Epigenetic Alterations | Identification of circulating microRNAs as potential biomarkers for detecting acute ischemic stroke. | 25410304 |
| atherosclerotic | Epigenetic Alterations | Globally, hypomethylation of chromosomal DNA predominates in atherosclerotic plaques and two-thirds of genes showing over 2.5-fold differential in DNA methylation are up-regulated in comparison to healthy mammary arteries. | 25411193 |
| Vascular Diseases | Epigenetic Alterations | These results suggest that epigenetic changes are involved in atherogenesis and may offer new potential therapeutic targets for vascular diseases. | 25411193 |
| Malignant tumor of colon, Neoplasms | Epigenetic Alterations | During 3,206,985 person-years of follow-up, we identified 993 rectal and colon cancer cases with an available tumor DNA methylation status. | 25411283 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | The association between alcohol intake and colorectal cancer risk may differ by tumor epigenetic features. | 25411283 |
| Pancreatic carcinoma | Epigenetic Alterations | Long noncoding RNA HULC is a novel biomarker of poor prognosis in patients with pancreatic cancer. | 25412939 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | The expression of multiple miRNAs, including miR-224, is deregulated in colorectal adenocarcinoma. | 25420464 |
| Sample Size Calculation | Epigenetic Alterations | Transcription factor Fli1, whose deficiency due to epigenetic suppression is implicated in the pathogenesis of SSc, occupied the CCN1 promoter and gene silencing of Fli1 resulted in the reduction of CCN1 expression in human dermal microvascular endothelial cells. | 25421497 |
| Sample Size Calculation | Epigenetic Alterations | This study further supports the idea that epigenetic downregulation of Fli1 is a potential predisposing factor in the pathogenesis of SSc. | 25421497 |
| Primary malignant neoplasm, Neoplasms, Cessation of life | Epigenetic Alterations | Evidence indicates that a HPV+ diagnosis has significant prognostic implications; these patients have at least half the risk of death when compared with the HPV- patient, due in part to a better response to chemoradiotherapy (Fakhry et al., J Natl Cancer Inst 100:261-269, 2008).Epigenetic events of promoter hypermethylation are emerging as promising molecular strategies for cancer detection, representing tumor-specific markers occurring early in tumor progression. | 25421671 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Clinical significance of microRNA-21 as a biomarker in each Dukes stage of colorectal cancer. | 25421755 |
| Malignant Neoplasms | Epigenetic Alterations | It is known that microRNA-21 (miR-21) is implicated in the promotion, proliferation and progression of several types of human cancers. | 25421755 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | The expression levels of miR-21 in the tumor tissues and normal adjacent tumor tissues of 306 CRC patients were determined by TaqMan microRNA assays. | 25421755 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | miRNA-34a-5p may play a role as a tumor suppressor gene in colorectal cancer, with involvement of DNA methylation. | 25422210 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Expression and clinical significance of miRNA-34a in colorectal cancer. | 25422210 |
| Primary malignant neoplasm | Epigenetic Alterations | Samples of cancer, paraneoplastic tissues and polyps were selected and total RNA was extracted by conventional methods for real-time PCR to detect the miRNA- 34a expression. | 25422210 |
| Colorectal Cancer Pathway | Epigenetic Alterations | In addition, the LOVO colorectal cancer cell line was cultured, treated with the demethylating agent 5-azacytidine and screened for differentially expressed miRNA-34a. | 25422210 |
| Colorectal Cancer Pathway | Epigenetic Alterations | After the drug treatment, the miRNA-34a expression of colorectal cancer cell line LOVO was increased and real-time PCR showed that levels of expression in both cell line and colorectal cancer tissues were low, as compared to paraneoplastic tissue (p<0.05). | 25422210 |
| In-Stent Restenosis Indicator | Epigenetic Alterations | Plasma microRNAs as potential noninvasive biomarkers for in-stent restenosis. | 25427155 |
| Neoplasms, Renal Cell Carcinoma Pathway | Epigenetic Alterations | miRNA-205 is a candidate tumor suppressor that targets ZEB2 in renal cell carcinoma. | 25427583 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | A 3-microRNA scoring system for prognostication in de novo acute myeloid leukemia patients. | 25428263 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | We thus analyzed the clinical, genetic and microRNA profiling data of 138 de novo AML patients of our institute. | 25428263 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | We conclude that this 3-microRNA scoring system is simple and powerful for risk stratification of de novo AML patients. | 25428263 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNAs have florid biological functions and have critical roles in the pathogenesis and prognosis in AML. | 25428263 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The development of human cancer is a multistep process characterized by the accumulation of genetic and epigenetic alterations that drive or reflect tumour progression. | 25428504 |
| Cerebrovascular accident | Epigenetic Alterations | These DNA methylation patterns could be used as future potential stroke biomarkers. | 25429063 |
| Cerebrovascular accident, Obesity | Epigenetic Alterations | Obesity and stroke are multifactorial diseases in which genetic, epigenetic and lifestyle factors are involved. | 25429063 |
| Cerebrovascular accident | Epigenetic Alterations | Furthermore, the epigenetic marks differentially methylated in the stroke patients were dependent on the previous obese state. | 25429063 |
| Degenerative polyarthritis | Epigenetic Alterations | Identification of long noncoding RNA associated with osteoarthritis in humans. | 25430712 |
| Degenerative polyarthritis | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) are an important class of genes involved in various biological functions; however, knowledge about lncRNAs in osteoarthritis (OA) is limited. | 25430712 |
| Malignant Neoplasms | Epigenetic Alterations | The clinical utility of microRNA-21 as novel biomarker for diagnosing human cancers. | 25431259 |
| Malignant Neoplasms | Epigenetic Alterations | Recently, microRNA-21 (miR-21) attracts much attention for its aberrant expression and has been widely studied in various cancers. | 25431259 |
| Pancreatic carcinoma | Epigenetic Alterations | However, the status of polycomb-associated histone modifications and their clinical implications in pancreatic cancer remain unclear. | 25431952 |
| Tetranitromethane, Metastasis, Neoplasms | Epigenetic Alterations | Furthermore, compared to the tumor, lymph node, metastasis (TNM) staging system, histone modifications can discriminate the survival difference more accurately, especially for patients with stage I or stage II tumors. | 25431952 |
| Pancreatic carcinoma | Epigenetic Alterations | We have proposed that epigenetic modifications may serve as discriminatory biomarkers for molecular staging of pancreatic cancer. | 25431952 |
| frontal lobe, Cessation of life | Epigenetic Alterations | Total RNA, including microRNAs, was isolated from the cerebellum of individuals who had died from severe frontal cortex injuries or due to natural causes of death (reference group). | 25432860 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Long non-coding RNA HOX transcript antisenseRNA (HOTAIR) has been widely identified to participate in tumour pathogenesis, acting as a promoter in colorectal cancer carcinogenesis. | 25432874 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | MicroRNA-520g induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7. | 25436421 |
| Hollings Cancer Center | Epigenetic Alterations | Aberrant expression of miRNAs contributes to HCC development. | 25436421 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | New findings have suggested the potential involvement of epigenetic mechanisms in Type 2 diabetes (T2DM) as a crucial interface between the effects of genetic predisposition and environmental influences. | 25437047 |
| Metabolic Diseases | Epigenetic Alterations | This finding highlights the potential role for epigenetic biomarkers as predictors of T2DM risk or other related metabolic disorders. | 25437047 |
| Adenoma of large intestine | Epigenetic Alterations | Using colorectal adenomas, we investigated nucleosome positioning, DNA methylation, and gene expression in the early stages of gene silencing. | 25437056 |
| Asthma Pathway | Epigenetic Alterations | MicroRNA-19a enhances proliferation of bronchial epithelial cells by targeting TGFbR2 gene in severe asthma. | 25443138 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant expression of microRNA-148a (miR-148a) has been reported in several types of malignancies. | 25444499 |
| Hollings Cancer Center | Epigenetic Alterations | miR-148a might act as a suppressor miRNA of HCC and it therefore has a potential role in prognosis of HCC patients. | 25444499 |
| Malignant Neoplasms, Ovarian Carcinoma | Epigenetic Alterations | MicroRNA-145 (miR-145) expression is downregulated in several human cancers, but its clinical and functional relevance to ovarian carcinoma has not yet been elucidated. | 25444913 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Long intergenic noncoding RNA POU3F3 (linc-POU3F3) has been characterized as a highly conserved functional transcription regulator in esophageal squamous cell carcinoma. | 25445282 |
| Primary malignant neoplasm | Epigenetic Alterations | Growing number of long intergenic noncoding RNAs (lincRNAs) have recently been identified in mammals as new modulators in cancer origination and progression involved in a broad range of biological processes. | 25445282 |
| Prostate Cancer Pathway | Epigenetic Alterations | Identification of cell-free microRNAs in the urine of patients with prostate cancer. | 25445383 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidence suggests that miRNAs play an important role in tumorigenesis, are differentially expressed in different cancer types, and can be found in all bodily fluids so-far tested, including urine. | 25445383 |
| Prostate Cancer Pathway | Epigenetic Alterations | Long noncoding RNA PCA3 gene promoter region is related to the risk of prostate cancer on Chinese males. | 25445501 |
| Hollings Cancer Center | Epigenetic Alterations | Among the 60 HCC cases, 76.7% (46/60) showed at elevated DNA methylation and displayed significantly lower levels of GPX3 mRNA and protein expression. | 25445749 |
| atherosclerotic | Epigenetic Alterations | The identification of miR-33b and miR-758 as putative key regulators of ABCA1 protein expression within human atherosclerotic plaques provides further data for the realization of new anti-atherosclerotic drugs with specific targets based on anti-miRNA technologies. | 25445880 |
| Malignant Neoplasms, Heart Diseases | Epigenetic Alterations | Recently, microRNAs have been detected in serum and plasma, and circulating microRNA (miRNA) profiles have now been associated with many diseases such as cancers and heart disease, as well as altered physiological states. | 25450382 |
| Ovarian Diseases | Epigenetic Alterations | A novel serum microRNA panel to discriminate benign from malignant ovarian disease. | 25451316 |
| Neoplasms | Epigenetic Alterations | MicroRNA profiling has allowed the identification of signatures associated with diagnosis, prognosis and response to treatment of human tumours. | 25451316 |
| Primary malignant neoplasm | Epigenetic Alterations | A panel of 4 microRNAs (let-7i-5p, miR-122, miR-152-5p and miR-25-3p) was significantly down regulated in cancer patients. | 25451316 |
| Carcinogenesis | Epigenetic Alterations | These microRNAs target WNT signalling, AKT/mTOR and TLR-4/MyD88, which have previously been found to play a role in ovarian carcinogenesis and chemoresistance. | 25451316 |
| Hepatitis B, Virus Diseases | Epigenetic Alterations | Differences in serum microRNA profiles in hepatitis B and C virus infection. | 25452043 |
| Viral hepatitis | Epigenetic Alterations | Serum microRNA levels reflect differences in the etiology and stage of viral hepatitis. | 25452043 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | Changes in epigenetic marks may help explain the late onset of Alzheimers disease (AD). | 25452147 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Interestingly, gene hypermethylation was detected in 13/37 tumors: 5/13 HNSCC cases had family history of cancer in first-degree relatives and 8/13 showed both, DNA methylation and PHF21B losses in the tumor sample. | 25454821 |
| PHF21B gene, Neoplasms | Epigenetic Alterations | These data suggest that PHF21B is a novel tumor suppressor gene that can be inactivated by genetic and epigenetic mechanisms in the human cancer. | 25454821 |
| Neoplasms | Epigenetic Alterations | MicroRNA-26a (miR-26a) functions as a tumor suppressor by regulating its direct target gene high mobility group AT-hook 1 (HMGA1). | 25455159 |
| Primary malignant neoplasm, Squamous Cell Carcinoma of the Penis | Epigenetic Alterations | Profiling of expression of human papillomavirus-related cancer miRNAs in penile squamous cell carcinomas. | 25455689 |
| Patient Satisfaction with Cancer Care Questionnaire | Epigenetic Alterations | Altered expression of miRNAs has been reported in HPV-related cervical and head and neck cancers, but such data have not been available for PSCC. | 25455689 |
| Condyloma, Human papilloma virus infection, Human Papillomavirus-Related Malignant Neoplasm in AIDS Patient | Epigenetic Alterations | We analyzed a series of 59 PSCCs and 8 condylomata for presence of HPV infection, for p16(INK4a), Ki-67, and p53 immunohistochemical expression, and for expression of a panel of cellular miRNAs (let-7c, miR-23b, miR-34a, miR-145, miR-146a, miR-196a, and miR-218) involved in HPV-related cancer. | 25455689 |
| Malignant Neoplasms | Epigenetic Alterations | The long non-coding RNA SChLAP1 was identified as the highest-ranked overexpressed gene in cancers with metastatic progression. | 25456366 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | Dicer expression and microRNA dysregulation associate with aggressive features in thyroid cancer. | 25456905 |
| Malignant Neoplasms, DICER1 protein, human | Epigenetic Alterations | Altered miRNA expression and down-regulation of Dicer has been shown in various cancers. | 25456905 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | These findings suggest that disruption in normal miRNA processing involving Dicer may play a role in thyroid cancer progression. | 25456905 |
| DICER1 protein, human, Malignant neoplasm of thyroid | Epigenetic Alterations | Dysregulation of Dicer and possibly altered expression of miRNAs are associated with aggressive features in thyroid cancers. | 25456905 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis | Epigenetic Alterations | Serum levels of microRNA-122 were significantly higher in acute hepatitis and CHC patients than in healthy donors (p<0.001). | 25461662 |
| Malignant neoplasm of breast | Epigenetic Alterations | Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers. | 25465188 |
| Hematopoietic Neoplasms | Epigenetic Alterations | A novel intragenic long non-coding RNA (lncRNA) IRAIN within the IGF1R locus has been recently identified in haematopoietic malignancies using RNA-guided chromatin conformation capture (R3C). | 25465188 |
| Parkinson Disease | Epigenetic Alterations | miRNA expression is highly sensitive to a drug therapy in Parkinsons disease. | 25465742 |
| Parkinson Disease | Epigenetic Alterations | miRNAs may play a role in the pathogenesis of Parkinsons disease. | 25465742 |
| Nerve Degeneration, Parkinson Disease | Epigenetic Alterations | It is necessary to continue the search for new miRNAs that may affect the development of neurodegeneration in Parkinsons disease. | 25465742 |
| Parkinson Disease | Epigenetic Alterations | It is probable that miRNAs are very sensitive to drug therapy and that the effects of therapy observed may be associated with changes in the levels of these miRNAs and their target genes in patients with Parkinsons disease. | 25465742 |
| Neoplasms | Epigenetic Alterations | Tumor-specific DNA methylation of the ST6GAL1 promoter region was frequently found in pT2-4 tumors (53.6% (22/41)), whereas only 13.8% (4/29) of pTa tumors showed ST6GAL1 promoter methylation. | 25465919 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Epigenetic inactivation of ST6GAL1 in human bladder cancer. | 25465919 |
| Esophagitis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Serum inflammatory miRNAs predict radiation esophagitis in patients receiving definitive radiochemotherapy for non-small cell lung cancer. | 25466375 |
| Toxicity aspects | Epigenetic Alterations | High serum miR-155 and miR-221 during the first 2 weeks of CRT were associated with the development of severe RIET, suggesting that these miRNAs may be useful as an early surrogate for this form of toxicity. | 25466375 |
| Glioblastoma Multiforme | Epigenetic Alterations | The contrasting epigenetic role of RUNX3 when compared with that of MGMT and TIMP3 in glioblastoma multiforme clinical outcomes. | 25467143 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | DNA methylation profiling reveals novel diagnostic biomarkers in renal cell carcinoma. | 25472429 |
| Malignant neoplasm of kidney, Conventional (Clear Cell) Renal Cell Carcinoma, Neoplasms | Epigenetic Alterations | Additionally, we identified a single panel of DNA methylation biomarkers that reliably distinguishes tumor from benign adjacent tissue in all of the most common kidney cancer histologic subtypes, and a second panel does the same specifically for clear cell renal cell carcinoma tumors. | 25472429 |
| Malignant neoplasm of kidney, Renal Cell Carcinoma Pathway | Epigenetic Alterations | These DNA methylation profiles provide insights into the etiology of renal cell carcinoma and, most importantly, demonstrate clinically applicable biomarkers for use in early detection of kidney cancer. | 25472429 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | Single nucleotide polymorphisms (SNPs) in the microRNA-binding sites in the 3 UTR region of target genes may result in the level change of target gene expression and subsequently susceptible to diseases, including cancer. | 25472585 |
| Metastasis, Neoplasms | Epigenetic Alterations | Our data suggest that polymorphisms of the microRNA-binding sites in the 3 UTR region of integrin are associated with GC susceptibility (rs2675), tumor stage (rs2675, rs17664, and rs3809865), and lymphatic metastasis (rs17664) in Chinese Han population. | 25472585 |
| Primary malignant neoplasm | Epigenetic Alterations | Association of MicroRNA-31-5p with Clinical Efficacy of Anti-EGFR Therapy in Patients with Metastatic Colorectal Cancer. | 25472647 |
| Clinical Coordinator | Epigenetic Alterations | We recently reported that microRNA-31 (miR-31)-5p may regulate BRAF activation and play a role in the signaling pathway downstream of EGFR in CRC. | 25472647 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Clinical Relevance of Plasma DNA Methylation in Colorectal Cancer Patients Identified by Using a Genome-Wide High-Resolution Array. | 25472652 |
| Malignant Neoplasms, Colorectal Cancer Pathway, Clinical Coordinator, Neoplasms | Epigenetic Alterations | DNA methylation is a potential tumor marker for several cancers, including colorectal cancer (CRC), because of its heritable and stable characteristics. | 25472652 |
| Clinical Coordinator | Epigenetic Alterations | DNA methylation patterns differed in CRC subtypes. | 25472652 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We were able to show for the first time that in plasma miRNA profiles change within days after colorectal cancer surgery. | 25472670 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Suitability of circulating miRNAs as potential prognostic markers in colorectal cancer. | 25472670 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNAs are crucial in cellular processes and have been shown to be abnormally expressed in cancer tissue and the circulation. | 25472670 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Our results underscore the role of the investigated miRNAs in colorectal cancer and their potential utility as prognostic biomarkers. | 25472670 |
| Functional disorder, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Adverse epigenetic signatures by histone methyltransferase Set7 contribute to vascular dysfunction in patients with type 2 diabetes mellitus. | 25472959 |
| Functional disorder | Epigenetic Alterations | Set7-induced epigenetic changes contribute to vascular dysfunction in patients with T2DM. | 25472959 |
| Primary malignant neoplasm | Epigenetic Alterations | Long intergenic noncoding RNAs (lincRNAs) play important roles in regulating various biological processes in cancer, including proliferation and apoptosis. | 25473900 |
| Primary malignant neoplasm | Epigenetic Alterations | Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) have been suggested to influence the occurrence and progression of cancer through altering the expression and biological function of miRNAs. | 25474430 |
| Neoplasms | Epigenetic Alterations | Epigenetic modifiers, including the histone deacetylase inhibitor vorinostat, may sensitize tumors to chemotherapy and enhance outcomes. | 25476537 |
| Septicemia, Traumatic injury, human herpesvirus 8 | Epigenetic Alterations | Cellular and Kaposis sarcoma-associated herpes virus microRNAs in sepsis and surgical trauma. | 25476907 |
| Septicemia | Epigenetic Alterations | Cellular and KSHV miRNAs are differentially expressed in sepsis and early postsurgical patients and may be exploited for diagnostic and therapeutic purposes. | 25476907 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Downregulation of microRNA-21 expression restrains non-small cell lung cancer cell proliferation and migration through upregulation of programmed cell death 4. | 25477028 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs are endogenous non-coding RNAs that play important roles in a wide variety of biological processes such as apoptosis, development, aging and cancer. | 25479763 |
| Malignant Neoplasms | Epigenetic Alterations | The loss of 5-hydroxymethylcytosine (5-hmC) has been identified as an epigenetic hallmark in several malignancies. | 25480415 |
| Conventional (Clear Cell) Renal Cell Carcinoma, Neoplasms | Epigenetic Alterations | Upregulation of long non-coding RNA MALAT1 correlates with tumor progression and poor prognosis in clear cell renal cell carcinoma. | 25480417 |
| Pancreatic carcinoma | Epigenetic Alterations | Overexpression of long non-coding RNA MALAT1 is correlated with clinical progression and unfavorable prognosis in pancreatic cancer. | 25481511 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been proved to serve as a critical role in cancer development and progression. | 25481511 |
| Carcinogenesis | Epigenetic Alterations | DNA methylation changes contribute to bladder carcinogenesis. | 25482586 |
| Thymic Carcinoma | Epigenetic Alterations | Mutations of epigenetic regulatory genes are common in thymic carcinomas. | 25482724 |
| Thymoma | Epigenetic Alterations | Our results suggest a potential disruption of epigenetic homeostasis in TCs, and a substantial difference in genetic makeup between TCs and thymomas. | 25482724 |
| SERPINB3 wt Allele | Epigenetic Alterations | Therefore, we evaluated the differential expression of six selected miRNAs namely hsa-miR-21, hsa-miR-125b2*, hsa-miR-138, hsa-miR-155, hsa-miR-184, and hsa-miR-205 in OSCC specimens of Indian ethnicity. | 25482863 |
| Alzheimers Disease", Neurodegenerative Disorders | Epigenetic Alterations | There is increasing evidence that epigenetic modifications may become compromised in aging and increase susceptibility to the development of neurodegenerative disorders such as Alzheimers disease. | 25484284 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNAs (miRNAs) have been implicated in colorectal cancer (CRC) development and associated with prognostic indicators such as disease stage and survival. | 25484364 |
| Clinical Coordinator | Epigenetic Alterations | In this study, we utilize population-based data from 1,141 CRC cases to replicate previously reported associations between 121 miRNAs and disease stage and survival. | 25484364 |
| Neoplasms | Epigenetic Alterations | Five miRNAs were associated with more advanced disease stage; hsa-miR-145-5p and hsa-miR-31-5p showed increased expression with more advanced tumor stage, while hsa-miR-200b-3p, hsa-miR-215 and hsa-miR-451a had decreased expression with more advanced tumors. | 25484364 |
| Clinical Coordinator, Rectal Carcinoma, Malignant tumor of colon | Epigenetic Alterations | Thirteen miRNAs were associated with CRC mortality among individuals diagnosed with colon cancer while 14 were associated with CRC mortality after a diagnosis with rectal cancer. | 25484364 |
| Neoplasms | Epigenetic Alterations | Strongest associations were observed for those miRNAs that were expressed in a small subset of tumors. | 25484364 |
| ovarian neoplasm | Epigenetic Alterations | Herpes virus microRNA expression and significance in serous ovarian cancer. | 25485872 |
| ovarian neoplasm | Epigenetic Alterations | Gene, miRNA expression, and cytotoxicity assay were performed on multiple ovarian cancer cell lines transfected with miR-H25 and miR-BART7. | 25485872 |
| ovarian neoplasm | Epigenetic Alterations | This is the first investigation linking viral miRNA expression to ovarian cancer outcome. | 25485872 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Age-dependent clinical prognostic value of histone modifications in colorectal cancer. | 25488396 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | We hypothesized that expression of histone modifications, acetylation of histone 3 lysine 9 (H3K9Ac) and trimethylation of histone 3 lysine 27 (H3K27me3), with reported normal age-related expression patterns might show an age-dependent prognostic value in colorectal cancer (CRC). | 25488396 |
| Tetranitromethane, Clinical Coordinator | Epigenetic Alterations | To quantify expression, we performed immunohistochemical staining of these histone modifications on a tissue microarray containing colorectal tissues of the 254 patients with TNM stage I-III CRC. | 25488396 |
| Clinical Coordinator | Epigenetic Alterations | These opposite expression patterns translated into an age-dependent prognostic value in CRC for the individual histone modifications and their combination. | 25488396 |
| Primary malignant neoplasm | Epigenetic Alterations | Furthermore, it is known that epigenetic mechanisms are involved in the development of cancer. | 25488396 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | The microRNA-367 inhibits the invasion and metastasis of gastric cancer by directly repressing Rab23. | 25489984 |
| Stomach Carcinoma | Epigenetic Alterations | Dysregulated expression of microRNAs is often found in gastric cancer, and it contributes to the pathogenesis of gastric cancer via regulation of the cell cycle, proliferation, apoptosis, migration, and invasion. | 25489984 |
| Merkel cell polyomavirus | Epigenetic Alterations | miRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma. | 25491743 |
| Neoplasms | Epigenetic Alterations | However, distinct miRNA expression profiles have been suggested for MCV-positive and MCV-negative tumors. | 25491743 |
| Neoplasms | Epigenetic Alterations | Neither tumor location nor development of metastases affected miRNA expression. | 25491743 |
| Metabolic Diseases, Autoimmune Diseases, Primary malignant neoplasm | Epigenetic Alterations | As a new class of microregulators of gene expression, miRNA have been reported to play vital roles in autoimmune diseases, metabolic diseases and cancer. | 25495156 |
| Vitiligo | Epigenetic Alterations | Our analysis showed that differentially expressed miRNA were associated with the mechanism of immune imbalance of vitiligo and that Ta1 could play an important role in changing the expression of these miRNA in the PBMC of patients with NSV. | 25495156 |
| Vitiligo | Epigenetic Alterations | This study provided further evidence that miRNA may serve as novel drug targets for vitiligo therapeutic evaluation. | 25495156 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | LEIGC long non-coding RNA acts as a tumor suppressor in gastric carcinoma by inhibiting the epithelial-to-mesenchymal transition. | 25496320 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs have been shown to have critical regulatory roles in cancer biology. | 25496320 |
| Malignant Neoplasms | Epigenetic Alterations | Forty-seven cancers varying by CIMP-status and IDH1 mutation status were examined using Illumina 450K DNA methylation microarrays. | 25496513 |
| Colorectal Cancer Pathway | Epigenetic Alterations | This study provides a precedent that a single gene mutation may cause CIMP in colorectal cancer, and that this will be associated with a specific epigenetic signature and clinicopathological features. | 25496513 |
| Neoplasms | Epigenetic Alterations | Patient, Design, Patients & Methods: MicroRNA expression signature was developed for RNA extracted from freshly frozen tumour and adjacent normal tissue (n = 5). | 25496852 |
| Colonic Neoplasms | Epigenetic Alterations | Identification of tissue specific microRNAs will help is designing microRNAs based gene therapies to control the development and progression of colonic neoplasia. | 25496852 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | MiR-score: a novel 6-microRNA signature that predicts survival outcomes in patients with malignant pleural mesothelioma. | 25497279 |
| Neoplasms | Epigenetic Alterations | Candidate microRNAs from microarray profiling of tumor samples from 8 long (median: 53.7 months) and 8 short (median: 6.4 months) survivors following extrapleural pneumonectomy (EPP) were validated by RT-qPCR in 48 additional EPP samples. | 25497279 |
| Antilymphocyte Serum | Epigenetic Alterations | For ALS, a total of 364 miRNAs were identified in the motor cortex, 91 being up-regulated and 233 down-regulated. | 25497327 |
| Antilymphocyte Serum | Epigenetic Alterations | This indicated that one of the miRNAs up-regulated in ALS (miR-338-3p) had already been identified in leukocytes, serum, cerebrospinal fluid and frozen spinal cord from ALS patients. | 25497327 |
| Carcinoma, Transitional Cell, Ulcerative Colitis, Neoplasms | Epigenetic Alterations | To analyze a possible correlation between a miRNA expression profile and important prognostic factors for pTa urothelial carcinomas (UC), including tumor size, multiplicity and episodes of recurrence. | 25498275 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | Micro RNA expression and prognosis in low-grade non-invasive urothelial carcinoma. | 25498275 |
| Neoplasms | Epigenetic Alterations | Statistical tests were used to compare tumor size, multiplicity and episodes of recurrence with miRNAs expression profiles. | 25498275 |
| Neoplasms | Epigenetic Alterations | The majority of miRNAs are down-regulated, except mir-10a, over-expressed in most of cases, seeming to have increased levels as tumor with more unfavorable prognostic factors. | 25498275 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | microRNA-137 functions as a tumor suppressor in human non-small cell lung cancer by targeting SLC22A18. | 25498886 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | As a result, bioinformatics analysis and luciferase reporter assay showed that microRNA (miRNA)-137 directly targeted SLC22A18 in NSCLC cells. | 25498886 |
| Aggressive Non-Hodgkin Lymphoma | Epigenetic Alterations | Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma. | 25498913 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | We identified a 27-miRNA signature that included v-myc avian myelomatosis viral oncogene homolog (MYC) targets and enabled the differentiation of BL from DLBCL, a distinction comparable with the "gold standard" GEP-defined diagnosis. | 25498913 |
| Diffuse Large B-Cell Lymphoma, Mediastinal (Thymic) Large B-Cell Lymphoma | Epigenetic Alterations | Distinct miRNA signatures were identified for DLBCL subgroups, including GCB-DLBCL, activated B-cell (ABC)-DLBCL, and PMBL. | 25498913 |
| Failure, Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | We also identified predictive miRNA biomarker signatures in DLBCL, including high expression of miR-155, which is significantly associated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) treatment failure. | 25498913 |
| Glioblastoma Multiforme, Primary malignant neoplasm, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA and mRNA expression data from glioblastoma (n = 475) and grade II and III glioma (n = 178) were accessed from The Cancer Genome Atlas. | 25499534 |
| Neoplasms | Epigenetic Alterations | The statistical significance of the microRNA signature was higher than MGMT methylation in temozolomide treated tumors. | 25499534 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The 9-microRNA risk score was validated in an independent dataset (p = 4.50e-02) and also stratified patients into high- and low-risk groups in lower grade glioma (p = 5.20e-03). | 25499534 |
| Glioblastoma Multiforme | Epigenetic Alterations | We have identified a novel, biologically relevant microRNA signature that stratifies high- and low-risk patients in glioblastoma. | 25499534 |
| Glioblastoma Multiforme | Epigenetic Alterations | The majority of the 9 microRNAs have been previously linked to glioblastoma biology or treatment response. | 25499534 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Usefulness of microRNA-375 as a prognostic and therapeutic tool in esophageal squamous cell carcinoma. | 25501018 |
| Neoplasms | Epigenetic Alterations | The growth of both the TE2 and T.Tn tumors in the miR-375 groups was significantly suppressed compared with that in the control-miRNA groups. | 25501018 |
| Lymphoma | Epigenetic Alterations | These epigenetic changes, seen in Tet2 insufficiency-triggered lymphoma, possibly contributed to predated outgrowth of Tfh-like cells and subsequent lymphomagenesis. | 25501021 |
| Metastasis, Neoplasms | Epigenetic Alterations | Low level of miRNA-148/152 members may associate with advanced stage, large tumor size, malignant cell differentiation, and metastasis. | 25501703 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs were previously proposed as promising novel biomarkers in cancer screening. | 25501703 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The combination of four candidate miRNAs exhibited the highest predictive accuracy in NSCLC screening compared with individual miRNAs (AUC = 0.97). | 25501703 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Hence, the four candidate miRNAs have great potential to serve as promising novel biomarkers in NSCLC screening. | 25501703 |
| Initiation | Epigenetic Alterations | MicroRNAs (miRNAs) are small noncoding RNAs with known regulatory functions in cancer initiation and progression. | 25501825 |
| Carcinoma of lung | Epigenetic Alterations | Transient and stable overexpression of mir-660 using miRNA mimics reduced migration, invasion, and proliferation properties and increased apoptosis in p53 wild-type lung cancer cells (NCI-H460, LT73, and A549). | 25501825 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | Our finding supports that mir-660 acts as a tumor suppressor miRNA and we suggest the replacement of mir-660 as a new therapeutic approach for p53 wild-type lung cancer treatment. | 25501825 |
| Neoplasms | Epigenetic Alterations | Deregulation of microRNAs is a frequent event in the tumorigenesis and tumor progression. | 25502080 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Although microRNA-200 (miR-200) family members are thought to play roles in tumorigenesis, their functions in carcinogenesis are tumor specific, and the underlying mechanism of action still remains elusive. | 25502084 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Long noncoding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression. | 25504755 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Recent evidence highlights long noncoding RNAs (lncRNA) as crucial regulators of cancer biology that contribute to essential cancer cell functions such as cell proliferation, apoptosis, and metastasis. | 25504755 |
| Carcinogenic Chlorinated Hydrocarbon | Epigenetic Alterations | We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC. | 25505813 |
| Hypoxia, Degenerative polyarthritis | Epigenetic Alterations | Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes. | 25510649 |
| Hypoxia | Epigenetic Alterations | These findings demonstrate a role for hypoxia in the regulation of anabolic and catabolic gene expression and the influence of changes in DNA methylation. | 25510649 |
| Degenerative polyarthritis | Epigenetic Alterations | There is also a growing body of evidence to support the role of epigenetic factors in the pathogenesis of OA. | 25510649 |
| Carcinogenesis, Stomach Carcinoma | Epigenetic Alterations | Dysregulation of specific microRNAs (miRNAs) is found to play a vital role in carcinogenesis and progression of gastric cancer (GC). | 25510669 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Evaluation of urinary miRNA-96 as a potential biomarker for bladder cancer diagnosis. | 25511320 |
| Malignant neoplasm of urinary bladder, Schistosomiasis, Lesion of bladder | Epigenetic Alterations | Urine cytology, serologic assessment of schistosomiasis and estimation of miRNA-96 by real-time PCR were carried out for 94 bladder cancer patients, 30 benign bladder lesions and 60 healthy individuals. | 25511320 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Urinary miRNA-96 is a good noninvasive diagnostic biomarker for bladder cancer. | 25511320 |
| Neoplasms | Epigenetic Alterations | Furthermore, we found that the promoter region of SRHC contains a CpG-rich island and that SRHC is down-regulated in tumors by DNA methylation. | 25512078 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Here, we identified a new long noncoding RNA designated as SRHC that is capable of inhibiting cancer proliferation and is down-regulated in tumors at least partly by DNA methylation. | 25512078 |
| Primary malignant neoplasm, Squamous cell carcinoma of esophagus | Epigenetic Alterations | We explored genome-wide DNA methylation data from The Cancer Genome Atlas project and identified a panel of tumor-related genes hypermethylated in ESCC. | 25514805 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | Global DNA methylation level, assessed by LINE-1, was significantly lower in ESCC than in normal mucosa (p < 0.0001), and lower in greater than or equal to T2 (n = 69) than T1 tumors (n = 45; p = 0.03). | 25514805 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic alterations contributing to this deadly cancer type that can be used as novel therapeutic or diagnostic targets are still poorly understood. | 25514805 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | This study demonstrates that epigenetic alterations of a panel of tumor-related genes and the noncoding region LINE-1 can be used as prognostic indicators and help in clinical management of ESCC patients. | 25514805 |
| Metastasis, Neoplasms | Epigenetic Alterations | MicroRNAs regulate gene expression at the posttranscriptional level and play important roles in tumor development, progression, and metastasis. | 25515201 |
| Atrophic | Epigenetic Alterations | We hypothesised that increased circulating and muscle growth and differentiation factor-15 (GDF-15) causes atrophy in ICUAW by changing expression of key microRNAs. | 25516419 |
| Muscular Atrophy | Epigenetic Alterations | GDF-15 may increase sensitivity to TGF-b signalling by suppressing the expression of muscle microRNAs, thereby promoting muscle atrophy in ICUAW. | 25516419 |
| Primary malignant neoplasm | Epigenetic Alterations | Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C. | 25518741 |
| Primary malignant neoplasm | Epigenetic Alterations | Our recent microRNA (miRNA) expression signatures of lung-SCC revealed that clustered miRNAs miR-1/133a were significantly reduced in cancer tissues. | 25518741 |
| Clinical Coordinator | Epigenetic Alterations | Our findings suggest that the rs2910164 polymorphism in pre-miRNA, miR-146a may be associated with the risk of CRC. | 25519012 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Evaluation of genetic variants in miRNAs in patients with colorectal cancer. | 25519012 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant expression and structural alteration of miRNAs are considered to participate in cancer development. | 25519012 |
| Clinical Coordinator, Disease, Colorectal Cancer Pathway | Epigenetic Alterations | It has been suggested that common single-nucleotide polymorphisms (SNPs) in miRNAs are associated with susceptibility to several human diseases including colorectal cancer (CRC). | 25519012 |
| Primary malignant neoplasm | Epigenetic Alterations | Abnormally expressed circulating microRNA (miRNA) may serve as a potential biomarker for the diagnosis of cancer patients. | 25519019 |
| Hepatitis B Virus-Related Hepatocellular Carcinoma | Epigenetic Alterations | Profiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma. | 25519019 |
| Hollings Cancer Center, Complete atrioventricular block | Epigenetic Alterations | Relative to healthy controls, nine, three, and 11 miRNAs were up-regulated in the CHB group, LC group and small HCC group, respectively. | 25519019 |
| Neoplastic disease | Epigenetic Alterations | MicroRNAs (miRNAs) are short, non-coding RNA molecules that are commonly dysregulated in neoplasia. | 25519020 |
| Clinical Coordinator | Epigenetic Alterations | MiRNA microarray expression profiling was performed with Agilents miRNA Microarray system on 12 CRC and 8 normal stool samples. | 25519020 |
| Clinical Coordinator | Epigenetic Alterations | In profiling study, we found 215 down-regulated miRNAs in CRC group. | 25519020 |
| Dental Plaque | Epigenetic Alterations | Plasma microRNA-100 is associated with coronary plaque vulnerability. | 25519160 |
| methionine, Squamous cell carcinoma of lung | Epigenetic Alterations | Tumor-suppressive microRNA-206 as a dual inhibitor of MET and EGFR oncogenic signaling in lung squamous cell carcinoma. | 25522678 |
| methionine | Epigenetic Alterations | Furthermore, putative miR-206 binding sites were annotated in the 3-UTRs of MET and EGFR RTKs in miRNA databases. | 25522678 |
| Atrial Fibrillation | Epigenetic Alterations | Left atrial transcriptional changes associated with atrial fibrillation susceptibility and persistence. | 25523945 |
| Degenerative polyarthritis | Epigenetic Alterations | Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients. | 25524778 |
| Degenerative polyarthritis | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have emerged as a novel class of regulatory molecules involved in various biological processes, but their role in osteoarthritis (OA) remains unknown. | 25524778 |
| Squamous cell carcinoma | Epigenetic Alterations | Expression and epigenetic regulation of DACT1 and DACT2 in oral squamous cell carcinoma. | 25524937 |
| Malignant Neoplasms | Epigenetic Alterations | Abnormal expression of microRNA-146 (miR-146) has been found in several classes of cancers. | 25524940 |
| F9 gene | Epigenetic Alterations | MicroRNA-146a and miR-146b expressed in thyroid tissue may act as potential biomarkers for PTC patients. | 25524940 |
| Primary malignant neoplasm | Epigenetic Alterations | Human miRNAs have emerged as potentially useful diagnostic and prognostic markers in cancer within the past decade. | 25524940 |
| Prostate Cancer Pathway | Epigenetic Alterations | These data demonstrate that JUNB/AP-1 cooperates with PTEN signalling as barriers to invasive prostate cancer, whose concomitant genetic or epigenetic suppression induce malignant progression. | 25526087 |
| Malignant Neoplasms, DICER1 protein, human, Pleuropulmonary blastoma, Stromal tumor of ovary | Epigenetic Alterations | Dicer is an essential component of the microRNA-producing machinery; germline mutations of DICER1 have been confirmed in familial pleuropulmonary blastoma, ovarian sex cord-stromal tumors, and other cancers. | 25526195 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA LSINCT5 predicts negative prognosis and exhibits oncogenic activity in gastric cancer. | 25526476 |
| Neoplasms | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) are recently discovered RNA transcripts that are aberrantly expressed in many tumor types. | 25526476 |
| Toxicity aspects, Drug-induced | Epigenetic Alterations | MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity. | 25527335 |
| Myeloproliferative disease | Epigenetic Alterations | Role of JAK2 V617F mutation and aberrant expression of microRNA-143 in myeloproliferative neoplasms. | 25527813 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Investigation of microRNA-155 as a serum diagnostic and prognostic biomarker for colorectal cancer. | 25528214 |
| Transcriptional Regulator ATRX, Human | Epigenetic Alterations | We demonstrate high-penetrance nonsense mutations in PDE4DIP (n = 4) as well as various missense mutations in the DNA damage response (PRKDC, AURKB, ERCC5, ATR, and ATRX) and epigenetic modulating enzymes (MLL3). | 25531179 |
| Pathology, Primary malignant neoplasm | Epigenetic Alterations | Altered DNA methylation is associated with important and common pathologies such as cancer. | 25531253 |
| Colorectal Cancer Pathway, Neoplasm Metastasis | Epigenetic Alterations | STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer. | 25531324 |
| Clinical Coordinator | Epigenetic Alterations | Moreover, STIM1 was found to be a direct target of miR-185, a microRNA (miRNA) that has not previously been reported to be involved in EMT, in both CRC tissues and cell lines. | 25531324 |
| Prostate Cancer Pathway | Epigenetic Alterations | Dysregulated microRNA-224/apelin axis associated with aggressive progression and poor prognosis in patients with prostate cancer. | 25532941 |
| Prostate Cancer Pathway, Malignant Neoplasms, CHOANAL ATRESIA, POSTERIOR, Neoplasms | Epigenetic Alterations | Our previous study revealed that microRNA (miR)-224 down-regulation could promote tumor progression of prostate cancer (PCa) and might be associated with poor biochemical recurrence-free survival of patients with this malignancy. | 25532941 |
| Primary central nervous system lymphoma | Epigenetic Alterations | Here we characterised microRNA (miRNA) fingerprints in the blood of PCNSL patients with short-term survival (STS) versus long-term survival (LTS) to assess their potential as novel prognostic biomarkers. | 25534293 |
| Primary central nervous system lymphoma | Epigenetic Alterations | Besides the known miRNAs we identified putative novel miRNA candidates with potential regulatory influence of PCNSL. | 25534293 |
| Primary central nervous system lymphoma | Epigenetic Alterations | In conclusion, peripheral blood miRNA expression patterns hold promise as a prognostic tool in PCNSL patients. | 25534293 |
| ovarian neoplasm | Epigenetic Alterations | The BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2. | 25537514 |
| ovarian neoplasm | Epigenetic Alterations | By analyzing multidimensional datasets of ovarian cancer patients from the TCGA data portal, we identified three miRNAs (hsa-miR-146a, hsa-miR-148a and hsa-miR-545) that target BRCA1/2 and were associated with overall survival and progression-free survival in patients with wild-type BRCA1/2. | 25537514 |
| Disease | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) play an important role in the pathogenesis of many human diseases. | 25542208 |
| Esophageal carcinoma, Neoplasm Metastasis | Epigenetic Alterations | TGF-b1 induces epigenetic silence of TIP30 to promote tumor metastasis in esophageal carcinoma. | 25544767 |
| Parkinson Disease | Epigenetic Alterations | We hypothesized that risk variants affect methylation of a putative promoter in SNCA intron 1, previously highlighted in epigenetic studies of Parkinsons disease. | 25545759 |
| Epithelial-myoepithelial carcinoma, Primary malignant neoplasm | Epigenetic Alterations | These 220 differentially expressed genes including microRNAs provide here a sufficiently large set to specifically define epithelial-myoepithelial carcinoma and to identify novel and potentially important targets for diagnosis, prognosis, and therapy of this cancer. | 25546727 |
| Stomach Carcinoma | Epigenetic Alterations | Expression of serum let-7c, let-7i, and let-7f microRNA with its target gene, pepsinogen C, in gastric cancer and precancerous disease. | 25549793 |
| Malignant Neoplasms | Epigenetic Alterations | Homeobox A5 (HOXA5) is a master regulator of the morphogenesis and cell differentiation, and its expression is also downregulated in many cancers mediated by DNA methylation. | 25549794 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA expressions in HPV-induced cervical dysplasia and cancer. | 25550598 |
| Lesion of cervix, Human papilloma virus infection | Epigenetic Alterations | Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. | 25550598 |
| Breast Carcinoma, Esophageal carcinoma, Malignant Neoplasms, Primary malignant neoplasm, Malignant neoplasm of urinary bladder, Colorectal Cancer Pathway | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and the lncRNA UCA1 is upregulated in several cancers such as bladder cancer, breast cancer and colorectal cancer, however, the contributions of UCA1 to esophageal cancer remain largely unknown. | 25550835 |
| Malignant tumor of colon | Epigenetic Alterations | MicroRNA-139-3p indicates a poor prognosis of colon cancer. | 25550849 |
| Neoplasms | Epigenetic Alterations | Dysregulation of long non-coding RNAs (lncRNAs) plays critical roles in tumor progression. | 25550852 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Association detection between genetic variants in the microRNA binding sites of toll-like receptors signaling pathway genes and bladder cancer susceptibility. | 25550860 |
| Primary malignant neoplasm | Epigenetic Alterations | However, most existing studies have been focused on individual genes or a single type of data, which may lack the power to detect the complex mechanisms of cancer formation by overlooking the interactions of different genetic and epigenetic factors. | 25551281 |
| ovarian neoplasm, Primary malignant neoplasm | Epigenetic Alterations | We propose an integrative framework to identify genetic and epigenetic features related to ovarian cancer and to quantify the causal relationships among these features using a probabilistic graphical model based on the Cancer Genome Atlas (TCGA) data. | 25551281 |
| Disease | Epigenetic Alterations | The proposed framework is effective in identifying possible important genetic and epigenetic features that are related to complex cancer diseases. | 25551281 |
| ovarian neoplasm | Epigenetic Alterations | The constructed Bayesian network has identified some new genetic/epigenetic pathways, which may shed new light into the molecular mechanisms of ovarian cancer. | 25551281 |
| cervical cancer | Epigenetic Alterations | Decreased expression of microRNA-126 is associated with poor prognosis in patients with cervical cancer. | 25551621 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-126(miR-126) has been shown to be frequently down-regulated in a variety of malignancies and act as a potential tumor suppressor. | 25551621 |
| Ovarian Serous Adenocarcinoma | Epigenetic Alterations | Identification of microRNAs and target genes involved in serous ovarian carcinoma and their influence on survival. | 25556270 |
| spindle orientation checkpoint, Ovarian Serous Adenocarcinoma | Epigenetic Alterations | To identify the expression of key microRNAs and their predicted target genes involved in serous ovarian carcinoma (SOC) and correlation between miRNAs and prognosis. | 25556270 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Epigenetic changes within the promoter regions of antigen processing machinery family genes in Kazakh primary esophageal squamous cell carcinoma. | 25556465 |
| Primary malignant neoplasm | Epigenetic Alterations | Posttranscriptional regulation of human leukocyte antigen class I (HLA-I) and antigen processing machinery (APM) proteins expression may be associated with novel epigenetic modifications in cancer development. | 25556465 |
| Neoplasms | Epigenetic Alterations | Only some of them result in genetic transcription, and silencing of HLA-B, ERp57, and LMP7 expression through hypermethylation of the promoters or other mechanisms may contribute to mechanisms of tumor escape from immune surveillance in Kazakh esophageal carcinogenesis. | 25556465 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Expression of tumor suppressive microRNA-34a is associated with a reduced risk of bladder cancer recurrence. | 25556547 |
| Neoplasms | Epigenetic Alterations | MicroRNA-34a (miR-34a) is a short noncoding regulatory RNA with tumor suppressive attributes. | 25556547 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | This panel of 5 serum miRNA may have the potential to be used clinically as an auxiliary diagnostic tool for the early detection of RCC. | 25556603 |
| Primary malignant neoplasm, Refractory Cytopenia of Childhood | Epigenetic Alterations | Circulating microRNAs (miRNAs) are emerging as clinically useful tools for cancer detection; however, little is known about their early diagnostic impact on RCC. | 25556603 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | A panel of five serum miRNAs as a potential diagnostic tool for early-stage renal cell carcinoma. | 25556603 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Markedly dysregulated miRNAs in RCC cases were subsequently validated individually by qRT-PCR in another 107 patients and 107 controls arranged in two sets. | 25556603 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Identification of high-risk Dukes B colorectal cancer by microRNA expression profiling: a preliminary study. | 25557290 |
| Metastasis, Neoplasms | Epigenetic Alterations | The study suggests that the development of metastasis in Dukes B tumours may be predictable based on the miRNA expression of miR-15b and miR-135b. | 25557290 |
| Colorectal Cancer Pathway, Metastasis, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) from tumour tissue and common gene mutations were studied to determine whether they predict the development of metastasis in patients with Dukes B colorectal cancer. | 25557290 |
| Colorectal Cancer Pathway, Metastasis, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MiRNAs from tumour and adjacent normal tissue and common gene mutations (KRAS, BRAF, PIK3CA) in primary cancer tissue were analysed to identify prognostic tissue markers for the development of metastasis in patients with Dukes B colorectal cancer. | 25557290 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Clinical significance of DNA methylation mRNA levels of TET family members in colorectal cancer. | 25557833 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Therefore, we investigated DNA methylation and mRNA levels of all TETs in colorectal cancer (CRC) patients. | 25557833 |
| cervical cancer | Epigenetic Alterations | Downregulation of microRNA-145 is associated with aggressive progression and poor prognosis in human cervical cancer. | 25560490 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in the processes of tumor initiation and progression. | 25560490 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | microRNA-328 is a favorable prognostic marker in human glioma via suppressing invasive and proliferative phenotypes of malignant cells. | 25562367 |
| Glioma, Neoplasms | Epigenetic Alterations | microRNA (miR)-328 has been reported to be implicated into tumorigenesis and tumor progression in human gliomas. | 25562367 |
| cervical cancer, Infection | Epigenetic Alterations | To evaluate how the genetic and epigenetic profile of human papillomavirus 16 (HPV16) changes from asymptomatic cervical infections to cervical cancer (CaCx) development. | 25563334 |
| Carcinoma of lung, Metastasis | Epigenetic Alterations | Inhibition of NADPH oxidase protects against metastasis of human lung cancer by decreasing microRNA-21. | 25563770 |
| Malignant Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Reduced expression of microRNA-134 correlates with malignancy and poor prognosis in human glioma. | 25564273 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-134 (miR-134) has been demonstrated to be dysregulated in glioma tissues. | 25564273 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | To identify tumor suppressor genes (TSGs) silenced by hypermethylation and discover new epigenetic biomarkers for early cancer detection. | 25569086 |
| Human papilloma virus infection | Epigenetic Alterations | DNA methylation in conjunction with HPV infection appears to play a role in OPSCC. | 25569158 |
| Depressive disorder, Minimal Disseminated Disease | Epigenetic Alterations | Current perspectives on the molecular underpinnings of major depressive disorder (MDD) posit a mechanistic role of epigenetic DNA modifications in mediating the interaction between environmental risk factors and a genetic predisposition. | 25571874 |
| Myocardial Ischemia | Epigenetic Alterations | Epigenetic screening may help identify determinants of therapeutic vasculogenesis in ischemic disease. | 25573856 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-15a down-regulation is associated with adverse prognosis in human glioma. | 25575767 |
| Squamous cell carcinoma of skin | Epigenetic Alterations | In order to elucidate the role of epigenetic alterations in the development of cutaneous squamous cell carcinoma (SCC), we analyzed both gene-specific promoter hypermethylation and repetitive sequence hypomethylation in cutaneous SCC as well as normal skin tissue samples. | 25575897 |
| Stomach Carcinoma | Epigenetic Alterations | Identification of long-range epigenetic silencing on chromosome 15q25 and its clinical implication in gastric cancer. | 25576785 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-93-5p (miR-93) is a novel oncogenic microRNA (miRNA) and is elevated in diverse human malignancies. | 25578493 |
| Periampullary Adenocarcinoma | Epigenetic Alterations | A total of 85 periampullary adenocarcinomas were characterized by mRNA and miRNA expressions profiling. | 25579086 |
| Periampullary Adenocarcinoma | Epigenetic Alterations | Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas. | 25579086 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers. | 25579142 |
| Breast Carcinoma | Epigenetic Alterations | Identification of obesity-associated epigenetic changes in breast tissue may advance mechanistic understanding of breast cancer initiation and progression. | 25583948 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | DNA methylation of ABCG1 might also play a role in previous hospitalized myocardial infarction (odds ratio, 1.15; 95% confidence interval=1.06-1.25). | 25583993 |
| Liver carcinoma | Epigenetic Alterations | Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. | 25584485 |
| Neoplasms | Epigenetic Alterations | A significant positive correlation was demonstrated by comparing the changes in tumour size with the changes in cir-miRNA-126, r=0.48, P=0.0001. | 25584492 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Opposite Prognostic Significance of Cellular and Serum Circulating MicroRNA-150 in Patients with Chronic Lymphocytic Leukemia. | 25584781 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNAs (or miRs) play a crucial role in chronic lymphocytic leukemia (CLL) physiopathology and prognosis. | 25584781 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Promoter DNA methylation and expression levels of HOXA4, HOXA5 and MEIS1 in acute myeloid leukemia. | 25585874 |
| Malignant Neoplasms, Breast Carcinoma, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Overexpression of Hox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with cancer cell proliferation, invasion, progression, and metastasis as well as poor survival in a variety of human cancers including breast cancer (BC). | 25586347 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | To assess the impact of arsenic exposure at a time progressive manner, we developed and characterized a cell culture model and tested a panel of miRNAs in urine samples from arsenic-exposed subjects, urothelial carcinoma patients, and controls. | 25586904 |
| Clinical Coordinator | Epigenetic Alterations | While, as expected, some miRNAs have been previously reported to be associated with CRC, including miR-21 and miR-145, others were new (miR-125a-5p and miR-320 family). | 25586944 |
| Clinical Coordinator | Epigenetic Alterations | Some miRNAs were specific for the CRC versus NOR comparison (miR-320b), or for the CRA versus NOR comparison (miR-15b or miR-16), but several of them (miR-21, miR-24, miR-145, mir-150, miR-378) were deregulated in both CRAs and CRCs, as compared to NOR. | 25586944 |
| Colorectal, Primary malignant neoplasm | Epigenetic Alterations | We confirmed that several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer. | 25586944 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Differences in the associations of a unique DNA methylation-based subgroup of colorectal cancer with important lifestyle and environmental exposures increase understanding of the molecular pathologic epidemiology of this heavily methylated subset of colorectal cancer. | 25587051 |
| Congenital heart disease | Epigenetic Alterations | DNA methylation abnormalities in congenital heart disease. | 25587870 |
| Deformity | Epigenetic Alterations | These epimutations likely contribute to the pathogenesis of the malformation by cis-acting effects on gene expression. | 25587870 |
| Congenital Heart Defects | Epigenetic Alterations | Our data indicate that epigenetic alterations of relevant genes are present in developing heart DNA in fetuses with both isolated and syndromic heart malformations. | 25587870 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic changes and functional study of HOXA11 in human gastric cancer. | 25590359 |
| Stomach Carcinoma | Epigenetic Alterations | To examine epigenetic changes and the function of HOXA11 in human gastric cancer (GC). | 25590359 |
| Malignant Neoplasms | Epigenetic Alterations | Dysregulation of long noncoding RNAs (lncRNAs) has been regarded as a primary feature of several human cancers. | 25590602 |
| Breast Carcinoma | Epigenetic Alterations | Comprehensive DNA Methylation and Extensive Mutation Analyses of HER2-Positive Breast Cancer. | 25591616 |
| HER2-positive carcinoma of breast | Epigenetic Alterations | Genes involved in cancer-related pathways were frequently affected not only by genetic but also by epigenetic alterations in HER2-positive breast cancer. | 25591616 |
| Neoplasms | Epigenetic Alterations | The EGFL7 VA was significantly higher and the miRNA-126 VA significantly lower in regional lymph node metastases compared to primary tumours, p = 0.01 and p < 10(-6), respectively. | 25592646 |
| Secondary malignant neoplasm of liver, Primary Neoplasm | Epigenetic Alterations | Furthermore, the miRNA-126 VA in liver metastases was significantly lower than in the primary tumours, p = 0.02. | 25592646 |
| Uveal melanoma | Epigenetic Alterations | Skewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma. | 25593028 |
| Primary malignant neoplasm | Epigenetic Alterations | Given the important role of epigenetic processes in cancer development and progression, we compared the transcriptional profiles of a selection of epigenetic regulators between primary UM with a good and a bad prognosis. | 25593028 |
| Neoplasms | Epigenetic Alterations | In the first set of tumors, general downregulation of transcription of the genes encoding epigenetic regulatory enzymes was seen in association with M3. | 25593028 |
| Uveal melanoma | Epigenetic Alterations | Expression levels of a number of histone-modifying genes and polycomb family members are significantly lower in uveal melanoma with monosomy 3/class 2, supporting a general dysregulation of epigenetic modifiers in UM with a bad prognosis. | 25593028 |
| Multiple Myeloma | Epigenetic Alterations | A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma. | 25593199 |
| Carcinoma of lung | Epigenetic Alterations | Sputum microRNA biomarkers for identifying lung cancer in indeterminate solitary pulmonary nodules. | 25593345 |
| Carcinoma of lung | Epigenetic Alterations | Using quantitative RT-PCR, we evaluated expressions of 13 sputum miRNAs, previously identified sputum miRNA signatures of lung cancer, in a training set of 122 patients with either malignant (n = 60) or benign SPNs (n = 62) to define a panel of biomarkers. | 25593345 |
| Peripheral Nerve Neoplasms, Malignant | Epigenetic Alterations | In the training set, a panel of three miRNA biomarkers (miRs21, 31, and 210) was developed, producing 82.93% sensitivity and 87.84% specificity for identifying malignant SPNs. | 25593345 |
| Carcinoma of lung, Peripheral Nerve Neoplasms, Malignant | Epigenetic Alterations | Sputum miRNA biomarkers may improve LDCT screening for lung cancer in heavy smokers by preoperatively diagnosing malignant SPNs. | 25593345 |
| Carcinoma of lung | Epigenetic Alterations | We have demonstrated that sputum miRNAs could provide potential biomarkers for lung cancer. | 25593345 |
| Adrenocortical carcinoma | Epigenetic Alterations | Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence. | 25595289 |
| Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) play an important role in cancer development. | 25595289 |
| Adrenal Gland Neoplasms | Epigenetic Alterations | Pathogenesis of adrenal tumours have been characterised by mRNA, microRNA and methylation expression signatures, but it is unknown if this extends to lncRNAs. | 25595289 |
| Adult T-Cell Lymphoma/Leukemia | Epigenetic Alterations | A frequently affected pathway was the JAK/STAT pathway (18%) and a significant proportion of T-ALL patients harboured mutations in epigenetic regulators (33%), both predominantly found in the unfavourable subgroup of early T-ALL. | 25595890 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-34a expression is predictive of recurrence after radiofrequency ablation in early hepatocellular carcinoma. | 25596083 |
| Hollings Cancer Center | Epigenetic Alterations | Previous studies have reported that aberrant expression of microRNA-34a (miR-34a) is involved in oncogenesis and progression of HCC. | 25596083 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Decreased expression of microRNA-107 predicts poorer prognosis in glioma. | 25596705 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-10b and minichromosome maintenance complex component 5 gene as prognostic biomarkers in breast cancer. | 25596707 |
| Breast Carcinoma | Epigenetic Alterations | The expression of miRNA-10b and MCM5 mRNA was positive in 86.4 and 79.7 % breast cancer patients, respectively. | 25596707 |
| Breast Carcinoma | Epigenetic Alterations | Thus, we could consider miRNA-10b and MCM5 mRNA as prognostic markers and potential therapeutic targets in breast cancer to be applied to other patient data sets. | 25596707 |
| Prostate Cancer Pathway, Disease, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Aberrant elevation of JARID1B and histone H3 lysine 4 trimethylation (H3K4me3) is frequently observed in many diseases including prostate cancer (PCa), yet the mechanisms on the regulation of JARID1B and H3K4me3 through epigenetic alterations still remain poorly understood. | 25596733 |
| Neoplasms | Epigenetic Alterations | In the tumors, miRNAs (miR-125b-5p, miR-126-5p, miR-151a-5p, miR-221-3p, and miR-222-3p) were significantly upregulated with downregulation of miR-486-5p. | 25597612 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The small RNA transcriptomes obtained in this study uncovers six differentially expressed miRNAs and 12 novel miRNAs, and provides a better understanding of the expression and function of miRNAs in the development of PCa and reveals several miRNAs in PCa that may have biomarker and therapeutic potentials. | 25597612 |
| Prostate Cancer Pathway | Epigenetic Alterations | Here, we report on the evaluation of the diagnostic performance of ejaculate-derived PCA3, Hepsin, and miRNAs to complement serum PSA to detect prostate cancer. | 25597828 |
| Prostate Cancer Pathway | Epigenetic Alterations | Furthermore, a combination of serum PSA and selected miRNAs improved prediction of prostate cancer status. | 25597828 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205. | 25600645 |
| Malignant Neoplasms, Refractory Cytopenia of Childhood, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Recently, long noncoding RNAs (lncRNA) have emerged as new gene regulators and prognostic markers in several cancers, including renal cell carcinoma (RCC). | 25600645 |
| Clinical Coordinator | Epigenetic Alterations | The molecular mechanisms underlying CRC development involve a multistep process with the accumulation of both genetic and epigenetic changes. | 25602156 |
| Adenocarcinoma, Dysplasia | Epigenetic Alterations | These polyps contain BRAF mutations and are prone to epigenetic methylation that ultimately silences MLH1, leading to MSI and heralding progression of dysplasia to invasive adenocarcinoma. | 25602793 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA 196B regulates FAS-mediated apoptosis in colorectal cancer cells. | 25605245 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-10b is upregulated and has an invasive role in colorectal cancer through enhanced Rhoc expression. | 25606801 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm | Epigenetic Alterations | A genome-wide investigation of microRNA expression identifies biologically-meaningful microRNAs that distinguish between high-risk and low-risk intraductal papillary mucinous neoplasms of the pancreas. | 25607660 |
| Malignant Neoplasms | Epigenetic Alterations | This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. | 25607660 |
| Pancreatic Cyst | Epigenetic Alterations | The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. | 25607660 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Decreased microRNA-132 and its function in human non-small cell lung cancer. | 25607827 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-132 (miR-132) has been shown to be dysregulated in certain types of human malignancies and is associated with tumor progression. | 25607827 |
| Prostate Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Our study provides evidence that EphA5 is a potential target for epigenetic silencing in primary prostate cancer and is a potentially valuable prognosis predictor and thereapeutic marker for prostate cancer. | 25609195 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer. | 25611389 |
| Clinical Coordinator | Epigenetic Alterations | Therefore, our data have revealed several hundred potential miRNA-mRNA regulatory networks in CRC and suggest targeting relevant networks as potential therapeutic strategy for CRC. | 25611389 |
| Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs have recently emerged as key regulators of cancer development and progression by targeting multiple cancer-related genes; however, such regulatory networks are not well characterized in CRC. | 25611389 |
| Clinical Coordinator | Epigenetic Alterations | Using target prediction and bioinformatics, ~77% of the upregulated genes were predicted to be targeted by microRNAs found to be downregulated in CRC. | 25611389 |
| Clinical Coordinator | Epigenetic Alterations | Significant inverse correlation between EZH2 and hsa-miR-26a-5p (R(2)=0.56, P=0.0001) and hsa-let-7b-5p (R(2)=0.19, P=0.02) expression was observed in the same samples, corroborating the belief of EZH2 being a bona fide target for these two miRNAs in CRC. | 25611389 |
| Lupus Erythematosus, Systemic, Lupus Erythematosus | Epigenetic Alterations | Histone acetylation modulates gene expression and has been described as increased in systemic lupus erythematosus (SLE). | 25611806 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | Histone acetylation was defined in monocytes and T cells from controls and SLE patients. | 25611806 |
| AMD1 wt Allele | Epigenetic Alterations | Results also suggest that the degree of whole blood DNA methylation is not a marker of AMD. | 25611924 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Long noncoding RNA MALAT1 associates with the malignant status and poor prognosis in glioma. | 25613066 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a bona fide long noncoding RNA (lncRNA). | 25613066 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | Aberrant methylation of genes is one of the most common epigenetic modifications involved in the development of urothelial carcinoma. | 25613404 |
| Neoplasms | Epigenetic Alterations | PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. | 25613750 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-149 suppresses colorectal cancer cell migration and invasion by directly targeting forkhead box transcription factor FOXM1. | 25613903 |
| Cancer Prognosis | Epigenetic Alterations | Sequence Variation in Mature MicroRNA-499 Confers Unfavorable Prognosis of Lung Cancer Patients Treated with Platinum-Based Chemotherapy. | 25614447 |
| Carcinoma of lung | Epigenetic Alterations | We found that the microRNA-499 rs3746444T>C polymorphism exhibited a consistently poor prognosis for patients with lung cancer in the discovery set [HR, 1.24; 95% confidence interval (CI), 1.02-1.49; P = 0.028], in the validation set I (HR, 1.31; 95% CI, 1.01-1.71; P = 0.048) and in the validation set II (HR, 1.45; 95% CI, 1.12-1.86; P = 0.004). | 25614447 |
| Low Grade Cervical Squamous Intraepithelial Neoplasia | Epigenetic Alterations | Aberrant DNA methylation of DLX4 and SIM1 is a predictive marker for disease progression of uterine cervical low-grade squamous intraepithelial lesion. | 25614457 |
| Communicable Diseases | Epigenetic Alterations | Aberrant DNA methylation of the DLX4 and SIM1 genes should be a novel progression marker for uterine cervical LSIL with hrHPV infection. | 25614457 |
| melanoma, Neoplasms | Epigenetic Alterations | Epigenetic modifications in cutaneous malignant melanoma: EZH2, H3K4me2, and H3K27me3 immunohistochemical expression is enhanced at the invasion front of the tumor. | 25614949 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Cancer stem cells and the misregulation of epigenetic modifications have been identified to possess a determinative role in carcinogenesis. | 25614949 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Tumor suppressor gene silencing through DNA methylation contributes to cancer formation. | 25616722 |
| BDI - Functional Impairment, Neoplasms, Neoplasm Metastasis | Epigenetic Alterations | Although deregulation of microRNA (miRNA) expression has been detected in many tumor types, the mechanisms underlying functional impairment and specific involvement of miRNAs in tumor metastasis remain unclear. | 25617495 |
| Heart failure | Epigenetic Alterations | Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction. | 25619197 |
| Squamous cell carcinoma of oropharynx | Epigenetic Alterations | Epigenetic changes in the CDKN2A locus are associated with differential expression of P16INK4A and P14ARF in HPV-positive oropharyngeal squamous cell carcinoma. | 25619363 |
| Oropharyngeal Carcinoma | Epigenetic Alterations | Overall, this study provides evidence of epigenetic changes to the downstream region of the CDKN2A locus in HPV+ oropharyngeal cancer that are associated with changes in expression of the coded protein products. | 25619363 |
| Multiple Pregnancy | Epigenetic Alterations | MicroRNAs (miRNAs) are small and highly conserved non-coding RNAs that regulate gene expression of target mRNAs through posttranscriptional inhibition involved in the tumorigenesis and progression of multiple malignancies. | 25620172 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-133a functions as a tumor suppressor in gastric cancer. | 25620172 |
| Clinical Coordinator | Epigenetic Alterations | Our results demonstrate that EYA4 is under epigenetic regulation in CRC. | 25620232 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Aberrant expression of microRNAs (miRs) has been proved to have a role in acute myeloid leukemias (AML), but there is no information on miR-331 in AML. | 25620533 |
| Chordoma | Epigenetic Alterations | Understanding epigenetic changes in chordomas may provide insights into chordoma tumorigenesis and development of epigenetic biomarkers. | 25621392 |
| Primary malignant neoplasm | Epigenetic Alterations | Preclinical studies suggest that noncytotoxic concentrations of the DNA methyltransferase 1 (DNMT1) inhibitor decitabine produce p53-independent cell-cycle exits by reversing aberrant epigenetic repression of proliferation-terminating (MYC-antagonizing) differentiation genes in cancer cells. | 25621498 |
| Neoplasms | Epigenetic Alterations | Overexpression of the miRNA cluster 182/96/183 is specific in SDHB-mutated tumours and induces malignant traits, whereas silencing of the imprinted DLK1-MEG3 miRNA cluster appears as a potential driver in a subgroup of sporadic tumours. | 25625332 |
| Polycystic Ovary Syndrome | Epigenetic Alterations | MicroRNA-181a (miR-181a) is thought to be involved in posterior capsule opacification (PCO). | 25626972 |
| Neoplasms | Epigenetic Alterations | Accumulating evidences indicate that microRNAs play a vital role in regulating tumor progression. | 25627001 |
| Ulcerative Colitis, Crohn Disease, Inflammatory Bowel Diseases | Epigenetic Alterations | MicroRNAs (miRNAs) are dysregulated in the inflammatory bowel diseases, Crohns disease (CD) and ulcerative colitis (UC), which arise due to dysfunctional host-microbe interactions and impairment of the barrier function of the intestine. | 25628040 |
| Ulcerative Colitis | Epigenetic Alterations | Here, we sought to determine whether circulating miRNAs are biomarkers of active colonic CD and UC and can provide insights into disease pathogenesis. | 25628040 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Comparison was made with serum miRNAs in patients with rheumatoid arthritis (RA). | 25628040 |
| Malignant Neoplasms, Cancer of Urinary Tract | Epigenetic Alterations | MicroRNAs play an important role in many human malignancies; so far, their expression remains to be studied in upper urinary tract urothelial cancer (UUTUC). | 25629698 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the blood and can serve as useful biomarkers for various types of cancer. | 25629978 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNA let-7a modifies the effect of self-renewal gene HIWI on patient survival of epithelial ovarian cancer. | 25630839 |
| ovarian neoplasm | Epigenetic Alterations | Aberrant expressions of self-renewal gene HIWI and microRNA (miRNA) let-7a are observed in epithelial ovarian cancer (EOC). | 25630839 |
| Adenocarcinoma Of Esophagus, Neoplasms | Epigenetic Alterations | Exosomal onco-miRs from serum of patients with adenocarcinoma of the esophagus: comparison of miRNA profiles of exosomes and matching tumor. | 25631748 |
| Neoplasms | Epigenetic Alterations | Oncogenic shuttle miRNAs present in exosomes may contribute to understanding how tumor cells spread their oncogenic potential to the environment. | 25631748 |
| Neoplasms | Epigenetic Alterations | Tumor specimens were analyzed for BRAF and KRAS mutations, CpG island methylator phenotype-specific promoters (CACNA1G, CDKN2A, IGF2 and RUNX3), IGFBP7, MGMT, MLH1 and RASSF2 methylation, microsatellite instability (MSI) and microRNA- 31 (miR-31). | 25632919 |
| KMT2A gene, Malignant neoplasm of larynx, Primary malignant neoplasm | Epigenetic Alterations | Deregulation of epigenetic effectors, including altered expression of histone methyltransferases from the MLL (mixed lineage leukemia) family, have been reported in many cancer types, yet little is known concerning their involvement in larynx cancer. | 25633166 |
| Stomach Carcinoma | Epigenetic Alterations | Gastric cancer (GC) is a biologically heterogeneous disease accompanying various genetic and epigenetic alterations, and the molecular mechanisms underlying this disease are complex and not completely understood. | 25633292 |
| Stomach Carcinoma, Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA-141 inhibits tumor growth and metastasis in gastric cancer by directly targeting transcriptional co-activator with PDZ-binding motif, TAZ. | 25633292 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | A tumor-specific microRNA signature predicts survival in clear cell renal cell carcinoma. | 25633718 |
| Malignant neoplasm of kidney, Conventional (Clear Cell) Renal Cell Carcinoma, Neoplasms | Epigenetic Alterations | Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancers in adults, and microRNAs (miRNAs) differentially expressed in ccRCC tumors have been identified and proposed to predict prognosis. | 25633718 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A. | 25633810 |
| Health maintenance | Epigenetic Alterations | Sequence variants in miRNAs of patients with HCM are not frequent and the contribution of these variants to the development of this disease was not demonstrated. | 25633875 |
| Multiple Myeloma | Epigenetic Alterations | Correlation between microRNA-21 and sprouty homolog 2 gene expression in multiple myeloma. | 25633921 |
| Cluster, Primary cutaneous B-cell lymphoma | Epigenetic Alterations | The High Expression of the microRNA 17-92 Cluster and its Paralogs, and the Downregulation of the Target Gene PTEN, Is Associated with Primary Cutaneous B-Cell Lymphoma Progression. | 25634356 |
| B-Cell Lymphomas | Epigenetic Alterations | The oncogenic microRNA (miR) 17-92 cluster has a causative role in the lymphomagenesis of nodal B-cell lymphomas, by activating proliferation and inhibiting apoptosis. | 25634356 |
| Liver carcinoma | Epigenetic Alterations | High serum microRNA-122 level is independently associated with higher overall survival rate in hepatocellular carcinoma patients. | 25636448 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNA-200c and microRNA-141 as potential diagnostic and prognostic biomarkers for ovarian cancer. | 25636451 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Decreased expression of long noncoding RNA MEG3 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer. | 25636452 |
| Breast Carcinoma | Epigenetic Alterations | Our results provide evidence that well-defined DNA methylation profiles enable breast cancer prediction and patient stratification. | 25636590 |
| Feel Pain, Fibromyalgia | Epigenetic Alterations | Recently, microRNA dysregulation has been reported in patients with painful conditions such as complex regional pain syndrome and fibromyalgia. | 25636687 |
| Migraine Disorders | Epigenetic Alterations | In conclusion, migraine manifestation is reflected in serum miRNA aberrations, both during attacks and pain-free periods. | 25636687 |
| Nerve Degeneration | Epigenetic Alterations | MicroRNAs have emerged as important biomarkers and modulators of pathophysiological processes including oncogenesis and neurodegeneration. | 25636687 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate a wide variety of cellular processes, and also play an important role in the development and progression of cancers. | 25637514 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation, which would be helpful in developing miRNA-based treatments for ESCC. | 25637514 |
| Carcinoma of lung | Epigenetic Alterations | Early Detection of Lung Cancer in Serum by a Panel of MicroRNA Biomarkers. | 25639977 |
| Carcinoma of lung | Epigenetic Alterations | The diagnostic value of the miRNA panel in an independent set of lung cancer patients confirmed the sensitivity and specificity. | 25639977 |
| Carcinoma of lung | Epigenetic Alterations | The results demonstrated that the panel of miRNA biomarkers had the potential for the early detection of lung cancer. | 25639977 |
| Carcinoma of lung | Epigenetic Alterations | The objective of the study was to develop a panel of microRNAs (miRNAs) as highly sensitive and specific biomarkers for lung cancer early detection. | 25639977 |
| Carcinoma of lung | Epigenetic Alterations | The combination of the 3 miRNAs could produce 0.936 area under the receiver operating characteristic curve value in distinguishing early stage lung cancer patients from control subjects with 87.5% sensitivity and 87.5% specificity, respectively. | 25639977 |
| Stomach Carcinoma | Epigenetic Alterations | Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene in gastric cancer development. | 25640751 |
| Congestive heart failure | Epigenetic Alterations | We demonstrated the increased expression levels of circulating miRNAs in CHF as compared with controls. | 25643195 |
| Breast Carcinoma | Epigenetic Alterations | Role of microRNAs -29b-2, -155, -197 and -205 as diagnostic biomarkers in serum of breast cancer females. | 25644077 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | The most significantly modulated miRNAs in stimulated CLL are miR-132 and miR-212. | 25645730 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | There is no clear understanding of the epigenetic alterations in hepatocellular carcinoma (HCC) and of the potential role of DNA methylation markers as prognostic biomarkers. | 25645722 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic deregulation has emerged as a driver in human malignancies. | 25645722 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. | 25646356 |
| Metastatic malignant neoplasm to brain, Neoplasms | Epigenetic Alterations | Comparing patients with and without brain metastases, the expression of miRNA-328 and miRNA-378 in tumor tissues were significantly different (P = 6.2 x 10(-5) and P = 2.8 x 10(-5), respectively). | 25646356 |
| Metastatic malignant neoplasm to brain, Neoplasms | Epigenetic Alterations | For the patients with brain metastases, the expression of miRNA-328 and miRNA-378 in tumor tissues compared with para-carcinoma tissues were also significantly different (P = 2.2 x 10(-5) and P = 1.6 x 10(-5), respectively). | 25646356 |
| Stomach Carcinoma | Epigenetic Alterations | Overexpression of E2F mRNAs associated with gastric cancer progression identified by the transcription factor and miRNA co-regulatory network analysis. | 25646628 |
| Stomach Carcinoma | Epigenetic Alterations | This study profiled differentially expressed mRNAs and miRNAs in gastric cancer tissues to construct a TF and miRNA co-regulatory network in order to identify altered genes in gastric cancer progression. | 25646628 |
| Stomach Carcinoma | Epigenetic Alterations | We obtained 887 up-regulated and 93 down-regulated genes and 41 down-regulated and 4 up-regulated miRNAs in gastric cancer tissues. | 25646628 |
| Carcinoma of lung | Epigenetic Alterations | NPTX1 is a novel epigenetic regulation gene and associated with prognosis in lung cancer. | 25646694 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | CpG island hypermethylation of gene promoters is a well-known mechanism of epigenetic regulation of tumor related-genes and is directly linked to lung carcinogenesis. | 25646694 |
| Carcinoma of lung | Epigenetic Alterations | Epigenetic alterations in NPTX1 may serve as potential diagnostic and prognostic biomarkers in lung cancer. | 25646694 |
| leukemia | Epigenetic Alterations | Emerging evidences have suggested that microRNAs are involved in the pathogenesis of various leukemias. | 25646775 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | Association of HPV with genetic and epigenetic alterations in colorectal adenocarcinoma from Indian population. | 25647260 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We studied the various genetic variations like microsatellite instability (MSI), oncogenic mutations and epigenetic deregulations like CpG island methylation in HPV associated and nonassociated colorectal cancer patients from Indian population. | 25647260 |
| Colorectal Cancer Pathway | Epigenetic Alterations | HPV in association with genetic and epigenetic features might be a potent risk factor for colorectal cancer in Indian population. | 25647260 |
| Meningioma | Epigenetic Alterations | Overall, the results of this study confirm that DNA methylation plays an important role in the pathogenesis of meningiomas. | 25648363 |
| Prostate Cancer Pathway | Epigenetic Alterations | Here, we studied the epigenetic alteration of DLEC1 and its functions in prostate cancer. | 25648635 |
| Prostate Cancer Pathway | Epigenetic Alterations | DLEC1 methylation is associated with prostate cancer progression, which could be a non-invasive epigenetic biomarker for PrCa diagnosis. | 25648635 |
| Ovarian Carcinoma | Epigenetic Alterations | RhoC is a major target of microRNA-93-5P in epithelial ovarian carcinoma tumorigenesis and progression. | 25649143 |
| Tuberculosis, Pulmonary | Epigenetic Alterations | Single nucleotide polymorphisms (SNPs) within precursor microRNAs (miRNAs) can affect miRNAs expression, and may be involved in the pathogenesis of pulmonary tuberculosis (TB). | 25650003 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | DNA methylation and RNA expression profiles in lung adenocarcinomas of never-smokers. | 25650174 |
| Carcinoma of lung | Epigenetic Alterations | Epigenetic changes in lung cancer potentially represent important diagnostic, prognostic, and therapeutic targets. | 25650174 |
| Stomach Carcinoma, Atypical Glandular Cell | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have been shown to be involved in the development and progression of advanced gastric cancer (AGC). | 25652469 |
| Communicable Diseases | Epigenetic Alterations | In summary, the expression pattern of miRNAs in the gastric mucosa is gradually increased with progression of Correas cascade and H.pylori infection, suggesting miRNAs as potential biomarkers for preneoplastic precursor conditions. | 25652892 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription; however, its role in bladder cancer remains largely unknown. | 25656485 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Our research demonstrated the expression and clinical role of the microRNA-regulating machinery in bladder cancer. | 25656609 |
| Heart failure | Epigenetic Alterations | MicroRNA-214 Is Upregulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis. | 25656649 |
| Cardiovascular Diseases | Epigenetic Alterations | More and more miRNAs have been shown to regulate gene expression in the heart and dysregulation of their expression has been linked to cardiovascular diseases including the miR-199a/214 cluster. | 25656649 |
| Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | We identified a large difference in miRNA-mRNA associations between CHD cases and controls, as demonstrated by a significantly higher proportion of inversely correlated miRNA-mRNA pairs in cases versus controls (80% versus 30%; P<1x10(-16)), suggesting a genome-wide shift in the regulatory structure of the transcriptome in CHD. | 25657313 |
| Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | Our results provide novel evidence that miRNAs are important regulators of biological processes involved in CHD via genetic control and via their tight coexpression with mRNAs. | 25657313 |
| Ischemic stroke | Epigenetic Alterations | microRNA (miRNA) plays a role in the pathogenesis of ischemic stroke, and single nucleotide polymorphisms in miRNA genes may contribute to disease susceptibility. | 25658319 |
| Cerebrovascular accident, Ischemic stroke | Epigenetic Alterations | In summary, this study provides evidence that miR-146a/rs2910164 might be associated with a significantly increased risk of ischemic stroke in a Chinese population, and the combined effects between miRNA polymorphism and fasting glucose /blood lipid levels may contribute to stroke pathogenesis. | 25658319 |
| Primary malignant neoplasm | Epigenetic Alterations | Single nucleotide polymorphisms (SNPs) in the 3-untranslated regions (UTRs) targeted by putative mircoRNAs (miRNAs) could influence the susceptibility of cancer. | 25661340 |
| Prostate Cancer Pathway | Epigenetic Alterations | Regulation of the ITGA2 gene by epigenetic mechanisms in prostate cancer. | 25662931 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic silencing of miR-137 is a frequent event in gastric carcinogenesis. | 25663388 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNA) are involved in posttranscriptional regulation of gene expression and are dysregulated during carcinogenesis. | 25663388 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Identification of a metastasis-specific MicroRNA signature in human colorectal cancer. | 25663689 |
| Secondary malignant neoplasm of liver, levamisole | Epigenetic Alterations | We performed a systemic, comprehensive discovery for expression patterns of metastasis-specific microRNAs (miRNAs) by directly comparing primary CRCs (pCRCs) and matched liver metastases (LMs) and evaluated the feasibility of their clinical application as metastasis-specific biomarkers. | 25663689 |
| Clinical Coordinator, Metastasis | Epigenetic Alterations | These unique miRNAs may be clinically applicable to predict prognosis and distant metastasis in CRC. | 25663689 |
| Prostate Cancer Pathway, Malignant Neoplasms, CHOANAL ATRESIA, POSTERIOR, Neoplasms | Epigenetic Alterations | Prostate cancer (PCa) represents one of the most complicated human tumors and, like many others malignancies, arises from progressive genetic and epigenetic alterations. | 25665470 |
| ibudilast | Epigenetic Alterations | Although the mechanisms deserve further investigation, microRNA is a potentially useful biomarker to differentiate IBD and MC. | 25665881 |
| Neoplasms | Epigenetic Alterations | Eight microRNAs (miR-4323, miR-625, miR-3619-3p, miR-4419b, miR-1249, miR-4648, miR-4664-3p and miR-1203) showed significant correlation with tumor relapse (p<0.01). | 25667451 |
| Neoplasms, KLK7 gene | Epigenetic Alterations | The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE. | 25667451 |
| Squamous cell carcinoma, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways. | 25668004 |
| SERPINB3 wt Allele | Epigenetic Alterations | An OSCC miRNA signature was constructed by PCR-based array methods. | 25668004 |
| Malignant Neoplasms, Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) have been shown to play major roles in carcinogenesis in a variety of cancers. | 25668004 |
| Primary malignant neoplasm | Epigenetic Alterations | Restoration of both miR-26a and miR-26b in cancer cell lines revealed that these miRNAs significantly inhibited cancer cell migration and invasion. | 25668004 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Downregulation of microRNA-1 in esophageal squamous cell carcinoma correlates with an advanced clinical stage and its overexpression inhibits cell migration and invasion. | 25672418 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Recent studies have suggested that an aberrant microRNA (miRNA or miR) expression signature exists in ESCC. | 25672418 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | A total of 43 differentially expressed miRNAs, including 27 downregulated and 16 upregulated miRNAs were found in the ESCC tissue samples. | 25672418 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | In addition, bioinformatics revealed that let-7, a microRNA formerly identified as an inhibiting factor of RCC was downregulated in RCC, which contrasted with S100A8. | 25673070 |
| Malignant tumor of colon | Epigenetic Alterations | The CARLo-5, a newly identified long non-coding RNA, was found to be upregulated in colon cancer. | 25674211 |
| Stomach Carcinoma | Epigenetic Alterations | Enhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer. | 25674211 |
| Primary malignant neoplasm | Epigenetic Alterations | The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are vital for understanding the molecular biology and progression of cancer. | 25674211 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-584 functions as a tumor suppressor and targets PTTG1IP in glioma. | 25674221 |
| Primary malignant neoplasm | Epigenetic Alterations | Compelling evidence shows that there are causative links between miRNAs deregulation and cancer development and progression. | 25674221 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Upregulation of microRNA-23a/b promotes tumor progression and confers poor prognosis in patients with gastric cancer. | 25674252 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Long non coding RNAs (lncRNAs) have emerged recently as major players in tumor biology and may be used for cancer diagnosis, prognosis, and potential therapeutic targets. | 25674259 |
| Lupus erythematosus tumidus, Stomach Carcinoma | Epigenetic Alterations | Down-regulation of long non-coding RNA LET is associated with poor prognosis in gastric cancer. | 25674261 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have emerged recently as major players in tumor biology and may be used for cancer diagnosis, prognosis, and potential therapeutic targets. | 25674261 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Lysine specific demethylase 1 (LSD1), the first characterized histone demethylase, roles importantly in epigenetic regulation of carcinogenesis and cancer progression. | 25674267 |
| Synucleinopathies, Behavior Disorders | Epigenetic Alterations | MicroRNA association with synucleinopathy conversion in rapid eye movement behavior disorder. | 25675938 |
| Synucleinopathies | Epigenetic Alterations | Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies. | 25675938 |
| Malignant Neoplasms | Epigenetic Alterations | Specimens underwent pyrosequencing for DNA methylation of genes reported to be hypermethylated in gynecologic cancers and recently identified markers discovered by profiling over 200 ECs. | 25677060 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Long noncoding RNA CCAT2 correlates with smoking in esophageal squamous cell carcinoma. | 25677908 |
| Down Syndrome | Epigenetic Alterations | Accelerated epigenetic aging in Down syndrome. | 25678027 |
| nervous system disorder, Osteochondritis Dissecans | Epigenetic Alterations | miRNAs, which are reported to be involved in the pathogenesis of the nervous system diseases, may also affect POCD. | 25680004 |
| Breast Carcinoma | Epigenetic Alterations | Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer. | 25680407 |
| Breast Carcinoma | Epigenetic Alterations | The microRNA 17-92 cluster host gene (MIR17HG) has been shown to regulate expression of genes involved in breast cancer development and progression. | 25680407 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation of cytosine (5-methylcytosine (5-mC)) in CpG dinucleotides is a common DNA modification; CpG dinucleotides are considered to be mutational hotspots that cause genetic diseases and cancers through spontaneous deamination of 5-mC, resulting in C-T transition mutations. | 25682017 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer. | 25682742 |
| Childhood Leukemia | Epigenetic Alterations | The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression. | 25682873 |
| Neoplastic disease | Epigenetic Alterations | Changes in the status of DNA methylation are one of the most common molecular alterations in human neoplasia. | 25684670 |
| Breast Carcinoma | Epigenetic Alterations | We aimed to identify epigenetic molecular markers in serum for early detection of breast cancer. | 25684670 |
| Stomach Carcinoma | Epigenetic Alterations | Antisense Long Noncoding RNA HIF1A-AS2 Is Upregulated in Gastric Cancer and Associated with Poor Prognosis. | 25686741 |
| Malignant Neoplasms | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have been recently shown to play important regulatory roles in fundamental biological processes, and many of them are deregulated in several human cancers. | 25686741 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Increasing evidence suggests that miRNAs can act as either tumor suppressors or oncogenes in carcinogenesis. | 25686834 |
| Carcinogenesis | Epigenetic Alterations | Small non-coding RNA deregulation in endometrial carcinogenesis. | 25686835 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Small non-coding RNAs (sncRNAs) represent a heterogeneous group of <200nt-long transcripts comprising microRNAs, PIWI-interacting RNAs (piRNAs) and small-nucleolar-RNAs (snoRNAs) involved in physiological and pathological processes such as carcinogenesis and tumor progression. | 25686835 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Aberrations in DNA methylation are detectable during remission of acute lymphoblastic leukemia and predict patient outcome. | 25687464 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation patterns are a hallmark of cancer, although the extent to which they underlie cancer development is unknown. | 25687464 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | The correlation between miRNA and lymph node metastasis in gastric cancer. | 25688358 |
| Prostate Cancer Pathway | Epigenetic Alterations | A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer. | 25691096 |
| Prostate Cancer Pathway | Epigenetic Alterations | We hypothesized that a comprehensive analysis of genetic variations found within the 3 untranslated region of genes predicted to affect miRNA binding (miRSNP) can identify additional prostate cancer risk variants. | 25691096 |
| Prostate Cancer Pathway | Epigenetic Alterations | Studies of miRNAs and their interactions with SNPs could provide further insights into the mechanisms of prostate cancer risk. | 25691096 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | We previously revealed genetic and epigenetic alterations associated with esophageal SCCs in relation to clinical outcome, including mutations in KRAS, BRAF, and PIK3CA, p53 expression, and long interspersed nucleotide element-1 (LINE-1) methylation, a surrogate marker for global DNA methylation level. | 25691283 |
| Squamous cell carcinoma of esophagus, Primary malignant neoplasm | Epigenetic Alterations | These findings imply that esophageal BSCC and SCC retain different cellular phenotypes with distinct genetic and epigenetic alterations; thus, tailored therapeutic strategies should be developed against each cancer type. | 25691283 |
| Primary malignant neoplasm | Epigenetic Alterations | In summary, most of the epigenetic drift seen in blood is independent of changes in blood cell type composition, and exhibits patterns at different genomic length scales reminiscent of those seen in cancer. | 25692570 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Development and blind clinical validation of a microRNA based predictor of response to treatment with R-CHO(E)P in DLBCL. | 25692889 |
| Primary malignant neoplasm | Epigenetic Alterations | Based on the measured growth inhibition of 60 human cancer cell lines (NCI60) in the presence of doxorubicine, cyclophosphamide, vincristine and etoposide as well as the baseline microRNA expression of the 60 cell lines, a microRNA based response predictor to CHOP was developed. | 25692889 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | It has been shown that microRNAs are independent predictors of outcome in patients with diffuse large B-cell lymphoma (DLBCL) treated with the drug combination R-CHOP. | 25692889 |
| Stomach Carcinoma | Epigenetic Alterations | Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls. | 25694351 |
| Stomach Carcinoma | Epigenetic Alterations | However, it is unclear if serum long noncoding RNAs (lncRNAs) represent a novel marker to detect gastric cancer (GC). | 25694351 |
| Esophageal carcinoma, Primary malignant neoplasm | Epigenetic Alterations | miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma. | 25695396 |
| Esophageal carcinoma, Metastasis | Epigenetic Alterations | We found that miRNA-1207-5p (miR-1207-5p) was markedly downregulated in esophageal carcinoma (EC) tissues, and was correlated with EC differentiation, pathological stage and lymph node metastasis. | 25695396 |
| Cerebrovascular accident, Acute Cerebrovascular Accidents | Epigenetic Alterations | The levels of miRNAs were compared with the presence of acute stroke, vascular risk factors, stroke subtypes, and stroke recurrence after index stroke. | 25697638 |
| Mycosis Fungoides | Epigenetic Alterations | Altered microRNA expression in folliculotropic and transformed mycosis fungoides. | 25698383 |
| Small cell carcinoma of lung | Epigenetic Alterations | MicroRNA-138 Regulates DNA Damage Response in Small Cell Lung Cancer Cells by Directly Targeting H2AX. | 25699650 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | MicroRNA-185 inhibits cell proliferation and induces cell apoptosis by targeting VEGFA directly in von Hippel-Lindau-inactivated clear cell renal cell carcinoma. | 25700976 |
| Alcoholic Intoxication, Chronic | Epigenetic Alterations | Recent studies have shown that smoking and alcoholism may be associated with altered DNA methylation and that alcohol consumption might induce changes in DNA methylation by altering homocysteine metabolism. | 25702197 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Here we sought to determine the differential gene and microRNA expressions associated with field of cancerization in the peripheral airway epithelial cells of patients with lung adenocarcinoma. | 25705890 |
| Primary malignant neoplasm | Epigenetic Alterations | We identified 26 mRNAs and 5 miRNAs that were significantly (FDR <0.1) up-regulated and 38 mRNAs and 12 miRNAs that were significantly down-regulated in the cancer patients when compared to smoker controls. | 25705890 |
| Pancreatic carcinoma, Liver and Intrahepatic Biliary Tract Carcinoma | Epigenetic Alterations | We found 81 miRNAs for pancreatic cancer and 66 miRNAs for biliary-tract cancer that showed statistically different expression compared with healthy controls. | 25706130 |
| Atrial Fibrillation | Epigenetic Alterations | Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation. | 25706326 |
| Stomach Carcinoma, Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA-181a inhibits tumor proliferation, invasiveness, and metastasis and is downregulated in gastric cancer. | 25706394 |
| Malignant Neoplasms, Stomach Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) play crucial roles in the development and progression of human cancers, including gastric cancer. | 25706394 |
| Stomach Carcinoma | Epigenetic Alterations | The discovery of miRNAs may provide a new and powerful tool for studying the mechanism, diagnosis, and treatment of gastric cancer. | 25706394 |
| Neoplasms | Epigenetic Alterations | Prediction of desmoid tumor progression using miRNA expression profiling. | 25707497 |
| hafnium | Epigenetic Alterations | As microRNAs (miRNAs) are key regulators in remodeling processes, a comparative miRNA profiling in transplanted hearts of HF patients with/without LVAD assistance could aid to comprehend underlying molecular mechanisms. | 25710008 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | De Novo Acute Myeloid Leukemia in Adults: Suppression of MicroRNA-223 is Independent of LMO2 Protein Expression BUT Associate With Adverse Cytogenetic Profile and Undifferentiated Blast Morphology. | 25710580 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNA (MIR) signatures are critical to pathobiology and prognosis of acute myeloid leukemia (AML). | 25710580 |
| cervical cancer | Epigenetic Alterations | MicroRNA-335 represents an independent prognostic marker in cervical cancer. | 25712373 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib. | 25712526 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | The identification of genetic determinants for this validated cancer biomarker should provide novel insights into mechanisms underlying epigenetic reprogramming during lung carcinogenesis. | 25713168 |
| Secondary malignant neoplasm of prostate | Epigenetic Alterations | Downregulation of microRNA-23a suppresses prostate cancer metastasis by targeting the PAK6-LIMK1 signaling pathway. | 25714010 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | A genetic variation in microRNA target site of KRT81 gene is associated with survival in early-stage non-small-cell lung cancer. | 25716425 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) have a key role in carcinogenesis through negative regulation of their target genes. | 25716425 |
| Carcinoma of lung | Epigenetic Alterations | Our findings underscore the impact of DNA methylation markers in symptomatic lung cancer diagnosis. | 25719833 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have shown to be promising novel biomarkers in various cancers. | 25720086 |
| Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear Features | Epigenetic Alterations | MicroRNA deep-sequencing reveals master regulators of follicular and papillary thyroid tumors. | 25720323 |
| Carcinogenesis | Epigenetic Alterations | MicroRNA deregulation could be a crucial event in thyroid carcinogenesis. | 25720323 |
| Neoplasms | Epigenetic Alterations | Furthermore, we integrated microRNA and gene expression data for the same tumors to propose targets for the novel molecules identified. | 25720323 |
| Neoplasms, Papillary neoplasm | Epigenetic Alterations | Two main microRNA expression profiles were identified: one common for follicular-pattern tumors, and a second for papillary tumors. | 25720323 |
| Follicular neoplasm | Epigenetic Alterations | Follicular tumors showed a notable overexpression of several members of miR-515 family, and downregulation of the novel microRNA miR-1247. | 25720323 |
| Papillary neoplasm | Epigenetic Alterations | Among papillary tumors, top upregulated microRNAs were miR-146b and the miR-221~222 cluster, while miR-1179 was downregulated. | 25720323 |
| Neoplasms | Epigenetic Alterations | Also, we confirmed that the PKM2/PKM1 ratio was further elevated in other PKM2-dominant organs such as colon through the down-regulation of these PTB1-associated microRNAs during tumor development. | 25721733 |
| Primary malignant neoplasm | Epigenetic Alterations | Compelling evidences have been demonstrated that microRNAs, a large family of single-stranded and non-protein-coding RNA molecules, can serve as useful biomarkers in cancer detection. | 25722112 |
| ovarian neoplasm | Epigenetic Alterations | Serum microRNA-145 as a novel biomarker in human ovarian cancer. | 25722112 |
| Disease | Epigenetic Alterations | In summary, we discuss the phenotypic and diagnostic challenges in clinical genetics, establish important differential diagnoses, and emphasize the cardinal features and the broad clinical spectrum of BAF complex disorders and other disorders caused by mutations in epigenetic landscapers. | 25724810 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Discovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression. | 25725128 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | We found 47 significantly differentially expressed serum miRNAs (p<0.05) in rapid progressive or slowly progressive IPF patients compared to healthy controls, including 21 up-regulated miRNAs and 26 down-regulated miRNAs. | 25725128 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | The unique circulating microRNAs (miRNAs) observed in patients with type 2 diabetes (T2D) are candidates as new biomarkers and therapeutic targets. | 25726255 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | The serum concentrations of miRNAs, log(10)miR-101, log(10)miR-375, and log(10)miR-802, were significantly increased in the T2D patients compared with NGT subjects (1.41+-2.01 v.s. | 25726255 |
| Coronary Artery Disease | Epigenetic Alterations | Here, we show that miR-320a, an intergenic miRNA, is markedly elevated in the peripheral blood of coronary heart disease patients and high-risk patients. | 25728840 |
| Carcinoma, Signet Ring Cell, Gastric Tubular Adenocarcinoma, Stomach Carcinoma | Epigenetic Alterations | Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer. | 25730011 |
| Carcinoma, Signet Ring Cell, Gastric Tubular Adenocarcinoma | Epigenetic Alterations | Thirteen dysregulated miRNAs were identified in signet-ring cell carcinoma compared with tubular adenocarcinoma: miR-30a, miR-26b, miR-381, let-7i, miR-29c, miR-543, miR-499-3p, miR-628-3p, miR-524-5p, miR-181b, miR-1914, miR-663b, and miR-676. | 25730011 |
| Acute lymphocytic leukemia, Childhood Leukemia | Epigenetic Alterations | In contrast to infant cases, MLL-R leukemia in older children had more somatic mutations (mean of 6.5 mutations/case versus 1.3 mutations/case, P = 7.15 x 10(-5)) and had frequent mutations (45%) in epigenetic regulators, a category of genes that, with the exception of MLL, was rarely mutated in infant MLL-R ALL. | 25730765 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-630 (miR-630) has been shown to be involved in various human malignancies. | 25731670 |
| Prostate Cancer Pathway | Epigenetic Alterations | Several expression profiling studies have provided evidence of aberrant expression of miRNAs in prostate cancer and have highlighted the potential use of specific miRNA expression signatures as prognostic or predictive markers. | 25731699 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, there has been increasing attention on the role of microRNAs (miRNAs) in cancer development. | 25731699 |
| Prostate Cancer Pathway | Epigenetic Alterations | qRT-PCR was performed to validate the differential expression of miRNAs in clinical samples, and the effect of miR-1247-5p was studied in prostate cancer cell lines transiently transfected with a miR-1247-5p mimic. | 25731699 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Upregulation of the long noncoding RNA PCAT-1 correlates with advanced clinical stage and poor prognosis in esophageal squamous carcinoma. | 25731728 |
| Prostate Cancer Pathway, Prostate | Epigenetic Alterations | Prostate cancer-associated ncRNA transcript 1 (PCAT-1) is one of the lncRNAs involved in cell apoptosis and proliferation of prostate cancer. | 25731728 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent studies reveal that long noncoding RNAs (lncRNAs) play critical regulatory roles in cancer biology. | 25731728 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | Breast Cancer: Radiogenomic Biomarker Reveals Associations among Dynamic Contrast-enhanced MR Imaging, Long Noncoding RNA, and Metastasis. | 25734557 |
| Medial collateral ligament | Epigenetic Alterations | Prognostic miRNAs were validated in diagnostic MCL samples from 94 patients of the independent Nordic MCL3 trial (validation cohort). | 25736311 |
| Medial collateral ligament | Epigenetic Alterations | Three miRNAs (miR-18b, miR-92a, and miR-378d) were significantly differentially expressed in patients who died of MCL in both cohorts. | 25736311 |
| Nasopharyngeal carcinoma, Neoplasms | Epigenetic Alterations | Protocadherin20 Acts as a Tumor Suppressor Gene: Epigenetic Inactivation in Nasopharyngeal Carcinoma. | 25736877 |
| Neoplasms | Epigenetic Alterations | Our study identified PCDH20 as a functional tumor suppressor and an important antagonist of Wnt/b-catenin signaling and EMT, with frequent epigenetic inactivation in NPC. | 25736877 |
| Intimal proliferation, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Aberrant expression of microRNAs is associated with neointimal hyperplasia (NIH) in type 2 diabetes. | 25737017 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Identification and validation of reference genes for the detection of serum microRNAs by reverse transcription-quantitative polymerase chain reaction in patients with bladder cancer. | 25738263 |
| Primary malignant neoplasm | Epigenetic Alterations | Serum microRNAs (miRNAs) have been proposed as novel non-invasive biomarkers for the early detection of cancer. | 25738263 |
| Nasopharyngeal carcinoma, Metastasis | Epigenetic Alterations | Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma. | 25738365 |
| Malignant Neoplasms, Nuclear Pore Complex | Epigenetic Alterations | MicroRNAs (miRNAs) play many important roles in human cancers; hence, we proceeded to address the primary hypothesis that there is a miRNA expression signature capable of predicting DM for NPC patients. | 25738365 |
| Diabetes Mellitus | Epigenetic Alterations | A 4-miRNA expression signature associated with risk of developing DM was identified by fitting a penalized Cox Proportion Hazard regression model to the Training data set (HR 8.25; p < 0.001), and subsequently validated in an independent Validation set (HR 3.2; p = 0.01). | 25738365 |
| Tetranitromethane | Epigenetic Alterations | This 4-miRNA signature adds to the prognostic value of the current "gold standard" of TNM staging. | 25738365 |
| Heart failure | Epigenetic Alterations | Significant differences in the miRNA expression profiles were observed between patients with different stages of heart failure following MI and individuals in the normal control group. | 25738515 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | A subset of circulating microRNAs is expressed differently in patients with myocardial infarction. | 25738515 |
| Breast Carcinoma | Epigenetic Alterations | microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53. | 25738546 |
| Neoplasms | Epigenetic Alterations | microRNA-214 (miR-214), a member of the miRNA family, has been demonstrated to function as both a tumor suppressor and oncogene in various types of human cancer. | 25738546 |
| Heart failure | Epigenetic Alterations | MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure. | 25739750 |
| Stomach Carcinoma, Aggressive behavior | Epigenetic Alterations | Epigenetic clustering of gastric carcinomas based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome. | 25740824 |
| Carcinogenesis | Epigenetic Alterations | The aim of this study was to clarify the significance of DNA methylation alterations during gastric carcinogenesis. | 25740824 |
| Stomach Carcinoma, Aggressive behavior | Epigenetic Alterations | These data indicate that DNA methylation profiles at the precancerous stage may be inherited by gastric carcinomas themselves, thus determining tumor aggressiveness and patient outcome. | 25740824 |
| Epstein-Barr virus associated gastric carcinoma | Epigenetic Alterations | The results demonstrated the antiapoptotic role of EBV miRNA via regulation of Bid expression in EBV-associated gastric carcinoma. | 25740983 |
| Stomach Carcinoma | Epigenetic Alterations | Profiling of Virus-Encoded MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma and Their Roles in Gastric Carcinogenesis. | 25740983 |
| Carcinogenesis | Epigenetic Alterations | These findings provide novel insights in the roles of EBV miRNAs in gastric carcinogenesis, which would be a potential therapeutic target. | 25740983 |
| Epstein-Barr virus associated gastric carcinoma | Epigenetic Alterations | This report is the largest series to comprehensively profile the expression of 44 known EBV miRNAs in clinical samples from EBV-associated gastric carcinoma patients. | 25740983 |
| Carcinogenesis | Epigenetic Alterations | Of the EBV miRNAs, ebv-miR-BART4-5p plays an important role in gastric carcinogenesis via regulation of apoptosis. | 25740983 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNAs can function as key tumor suppressors or oncogenes and act as biomarkers for cancer diagnosis or prognosis. | 25742499 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumor suppressor genes due to promoter hypermethylation is one of the frequent mechanisms observed in cancers. | 25743838 |
| ovarian neoplasm, Ascites | Epigenetic Alterations | [Elevated levels of dendritic cell-correlated miRNAs in ascites and sera of patients with ovarian cancer]. | 25744846 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA has become an ideal biomarker for cancer diagnosis, prognosis and therapy. | 25746592 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The relationship between microRNA-141 and non-small cell lung cancer (NSCLC) is contradictory. | 25746592 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The expression level of microRNA-141 was significantly higher in NSCLC tissues than in adjacent lung tissues (P < 0.001), detected by real time RT-PCR. | 25746592 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Receiver operating characteristic (ROC) exhibited a moderate diagnostic value of microRNA-141 for NSCLC with the area under curve of 0.707. | 25746592 |
| Metastasis, Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | The microRNA-141 expression increased with the larger tumor size (P = 0.002), lymph node metastasis (P = 0.018) and advanced stage (P = 0.022) in NSCLC patients. | 25746592 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In conclusion, microRNA-141 is a potential biomarker for the molecular diagnosis and risk stratification of NSCLC. | 25746592 |
| Hypoxia, Metastasis, melanoma | Epigenetic Alterations | A direct plasma assay of circulating microRNA-210 of hypoxia can identify early systemic metastasis recurrence in melanoma patients. | 25749524 |
| Neoplasms | Epigenetic Alterations | MicroRNA-210(miR-210) is known to play important roles in the tumor hypoxic state. | 25749524 |
| Constipation | Epigenetic Alterations | The Relationship Between Colonic Macrophages and MicroRNA-128 in the Pathogenesis of Slow Transit Constipation. | 25749934 |
| Constipation | Epigenetic Alterations | Compared to controls, 20 of 25 slow transit constipation patients (80 %) had significantly higher numbers of macrophages in colonic specimens, coupled with down-regulation of microRNA-128. | 25749934 |
| Constipation | Epigenetic Alterations | However, there are almost no data concerning colonic macrophages and microRNAs in slow transit constipation. | 25749934 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Recent studies have revealed dysregulated expression of several microRNAs (miRNAs) in various cancer tissues, and therefore, these cancer-associated miRNAs (also called onco-miRs) could be promising prognostic biomarkers of cancer progression or metastasis. | 25750291 |
| SCGB3A1 wt Allele, Glioblastoma Multiforme | Epigenetic Alterations | HIN-1: a New Epigenetic Biomarker Crucial for Therapy Selection in Glioblastoma Multiforme. | 25752997 |
| Tuberculosis | Epigenetic Alterations | Identification of miR-93 as a suitable miR for normalizing miRNA in plasma of tuberculosis patients. | 25753045 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | GSTP1 promoter hypermethylation was found as the earliest and a long-lasting epigenetic marker in blood samples of PCa patients, which makes it suitable as a marker for treatment follow-up. | 25753984 |
| melanoma | Epigenetic Alterations | Though rare, the identification of SMARCB1 mutations adds to the growing literature regarding the role of epigenetic control mechanisms in melanoma progression and therapeutic resistance and provide a rationale for strategies targeting such alterations (via chromatin remodeling agents) in clinical trials. | 25754356 |
| Colorectal Cancer Pathway, Metastasis, Squamous cell carcinoma of esophagus | Epigenetic Alterations | MiR-1179, a new identified miRNA highly associated with metastasis of colorectal cancer which was never reported in esophageal squamous cell carcinoma (ESCC). | 25755718 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are a class of small, non-coding RNAs, which have demonstrated to important gene regulators, and have critical roles in diverse biological processes including cancer cell proliferation. | 25755720 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-338-3p inhibits cell proliferation in hepatocellular carcinoma by target forkhead box P4 (FOXP4). | 25755720 |
| Carcinoma of lung, Stomach Carcinoma, Colorectal Carcinoma, Neoplasms | Epigenetic Alterations | Previous studies suggested microRNA-338-3p (miR-338-3p) was down-regulated and play tumor suppressor roles in gastric cancer, colorectal carcinoma and lung cancer. | 25755720 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Long noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer. | 25755750 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Linc-UBC1, a recently identified long noncoding RNA, was initially found to be upregulated in bladder cancer. | 25755750 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Downregulation of microRNA-504 is associated with poor prognosis in high-grade glioma. | 25755767 |
| Primary malignant neoplasm, Hypopharyngeal Squamous Cell Carcinoma, Neoplasms | Epigenetic Alterations | On the other hand, a recent study revealed that miR-504 inhibits cancer cell proliferation through targeting CDK6 in hypopharyngeal squamous cell carcinoma (HSCC), suggesting the tumor suppressive role of this miRNA. | 25755767 |
| Neoplasms | Epigenetic Alterations | Recent study indicated that microRNAs (miRNAs) played critical roles in tumor progression. | 25755771 |
| Malignant Neoplasms | Epigenetic Alterations | MiRNAs are stable molecules in blood and used as biomarkers for the early diagnosis of various malignancy. | 25755772 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA CCAT2 is up-regulated in gastric cancer and associated with poor prognosis. | 25755774 |
| Neoplasms | Epigenetic Alterations | Dysregulation of long non-coding RNAs (lncRNAs) play important roles in tumor progression. | 25755774 |
| Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA-106b (miR-106b) is thought to be an oncogenic microRNA that promotes tumor growth and metastasis. | 25755775 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-148b is down-regulated in non-small cell lung cancer and associated with poor survival. | 25755777 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Increased expression of microRNA-150 is associated with poor prognosis in non-small cell lung cancer. | 25755784 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. | 25756049 |
| Glioblastoma Multiforme | Epigenetic Alterations | Differential expression of microRNAs in postoperative radiotherapy sensitive and resistant patients with glioblastoma multiforme. | 25758051 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in the initiation and progression of a multitude of tumors. | 25758051 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Upregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients. | 25759982 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRs) have been shown to negatively regulate gene expression by binding to mRNAs, and they play an important role in various physiological processes and malignancies. | 25759982 |
| Malignant Neoplasms | Epigenetic Alterations | Cervical cancers exhibit aberrant cellular microRNA (miRNA) expression patterns. | 25760330 |
| Primary malignant neoplasm | Epigenetic Alterations | The E6/E7-regulated miRNAs are enriched for species involved in the control of cell proliferation, senescence and apoptosis, suggesting that they contribute to the growth of HPV-positive cancer cells. | 25760330 |
| Prostate Cancer Pathway | Epigenetic Alterations | To develop a microRNA (miRNA)-based predictive model for prostate cancer patients of 1) time to biochemical recurrence after radical prostatectomy and 2) biochemical recurrence after salvage radiation therapy following documented biochemical disease progression post-radical prostatectomy. | 25760964 |
| Primary malignant neoplasm | Epigenetic Alterations | Retinoid X receptor (RXR) and Histone deacetylase (HDAC) are considered important targets for cancer therapy due to their crucial roles in genetic or epigenetic regulations of cancer development and progression. | 25762635 |
| Diffuse Large B-Cell Lymphoma, Lymphoma | Epigenetic Alterations | Enhancer of Zeste Homolog 2 (EZH2) plays an essential epigenetic role in Diffuse Large B Cell Lymphoma (DLBCL) development. | 25762637 |
| Pulmonary Hypertension | Epigenetic Alterations | Discordant Regulation of microRNA Between Multiple Experimental Models and Human Pulmonary Hypertension. | 25763574 |
| Pulmonary arterial hypertension, 4-aminohippuric acid | Epigenetic Alterations | The dysregulation of microRNA (miRNA) is known to contribute to the pathobiology of pulmonary arterial hypertension (PAH). | 25763574 |
| Pulmonary Hypertension | Epigenetic Alterations | However, the relationships between changes in tissue and circulating miRNA levels associated with different animal models and human pulmonary hypertension (PH) have not been defined. | 25763574 |
| Hypoxia | Epigenetic Alterations | A set of miRNAs that have been causally implicated in PH, including miR-17, -21, -130b, -145, -204, -424, and -503, were measured by reverse transcription-quantitative polymerase chain reaction in the plasma, lung, and right ventricle of three of the most common rodent models of PH: the rat monocrotaline and SU5416 plus chronic hypoxia (SuHx) models and the mouse chronic hypoxia model. | 25763574 |
| Disease, Cardiovascular Diseases | Epigenetic Alterations | In addition, microRNAs have been implicated in the pathogenesis of a large number of diseases, including cardiovascular diseases, and are considered as promising candidate biomarkers due to their relative stability and easy quantification from clinical samples. | 25763857 |
| Heart failure | Epigenetic Alterations | However, several previously identified heart failure marker microRNAs were detected. | 25763857 |
| Carcinoma of lung | Epigenetic Alterations | Expression and significance of circulating microRNA-31 in lung cancer patients. | 25765717 |
| Carcinoma of lung | Epigenetic Alterations | Real-time fluorescent quantitative PCR was utilized to detect the circulating miRNA-31 expression levels in 300 lung cancer patients and 300 health control subjects. | 25765717 |
| Carcinoma of lung | Epigenetic Alterations | The 300 lung cancer patients were divided into a miRNA-31 low-expression group and a miRNA-31 high-expression group. | 25765717 |
| Carcinoma of lung | Epigenetic Alterations | The circulating miRNA-31 expression levels in the lung cancer patients (l.88+-0. | 25765717 |
| Carcinoma of lung | Epigenetic Alterations | When the critical value was 1.27, the sensitivity and specificity for lung cancer diagnosis according to the circulating miRNA-31 expression levels were 0.769 and 0.745, respectively. | 25765717 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNA-31 may be a molecular marker for the diagnostic and prognostic evaluation of primary lung cancer. | 25765717 |
| Dengue Fever | Epigenetic Alterations | Time since onset of disease and individual clinical markers associate with transcriptional changes in uncomplicated dengue. | 25768297 |
| Adenoma | Epigenetic Alterations | Differences in miRNA levels between the nonadvanced adenoma group and controls were modest. | 25770825 |
| Clinical Coordinator, Colorectal Neoplasms | Epigenetic Alterations | Our study found that expression of many miRNAs in serum was inversely correlated with the severity of colorectal neoplasia, and differential miRNA profiles were apparent in preneoplastic cases with advanced lesions, suggesting circulating miRNAs could serve as potential biomarkers for CRC screening. | 25770825 |
| Colorectal Neoplasms | Epigenetic Alterations | Differential expression of circulating microRNAs according to severity of colorectal neoplasia. | 25770825 |
| Clinical Coordinator, Neoplastic disease, Adenoma | Epigenetic Alterations | Of the 175 miRNAs, 106 miRNAs were downregulated according to severity of neoplasia and showed a relative decrease in the expression from controls to nonadvanced adenoma to advanced adenoma to CRC (Ptrend < 0.05). | 25770825 |
| Clinical Coordinator, Adenoma | Epigenetic Alterations | Pairwise group comparisons showed that 39 and 80 miRNAs were differentially expressed in the advanced adenoma and CRC groups compared with the controls, respectively. | 25770825 |
| Malignant Neoplasms | Epigenetic Alterations | Global miRNA expression profile has been widely used to characterize human cancers. | 25771723 |
| Gastric Adenocarcinoma | Epigenetic Alterations | Genome-wide miRNA microarray was employed for assessment of miRNA expression profile of gastric adenocarcinoma (GAC). | 25771723 |
| Glioma | Epigenetic Alterations | Correlation of microRNA-10b upregulation and poor prognosis in human gliomas. | 25773393 |
| Stage II Colorectal Cancer | Epigenetic Alterations | MicroRNA expression profile in patients with stage II colorectal cancer: a Turkish referral center study. | 25773836 |
| Colorectal Cancer Pathway | Epigenetic Alterations | There are increasing data about microRNAs (miRNA) in the literature, providing abundant evidence that they play important roles in pathogenesis and development of colorectal cancer. | 25773836 |
| Malignant tumor of colon | Epigenetic Alterations | Expression of 16 miRNAs (miRNA-9, 21, 30d, 31, 106a, 127, 133a, 133b, 135b, 143, 145, 155, 182, 200a, 200c, 362) was verified by quantitative real-time polymerase chain reaction (qRT-PCR) in all resected colon cancer tissue samples and in corresponding normal colonic tissues. | 25773836 |
| Primary malignant neoplasm | Epigenetic Alterations | When we compared subgroups, miRNA expression profiles of 20 recurrent cancer tissues were similar to all 40 cancer tissues. | 25773836 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior. | 25773836 |
| Breast Carcinoma | Epigenetic Alterations | To identify a prognostic signature for breast cancer, we performed DNA methylation profiling and identified methylation markers that were associated with expression of ER, PR, HER2, CK5/6, and EGFR proteins. | 25773928 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | These results suggest that integrated analysis of tumor expression markers, DNA methylation, and mRNA data may be an important approach for identifying breast cancer prognostic signatures. | 25773928 |
| Hollings Cancer Center | Epigenetic Alterations | Researches have shown that miRNAs have been proposed as novel diagnostic biomarkers for classification and prognostic stratification of HCC. | 25775917 |
| Malignant Neoplasms, Metastasis | Epigenetic Alterations | miR-338-3p, a recently discovered miRNA, has been shown to play important roles in tumorigenesis and metastasis in various cancers. | 25776272 |
| Malignant Neoplasms | Epigenetic Alterations | The DNA methylation alterations occurring in human cancers have two types: global DNA hypomethylation and site-specific CpG island promoter hypermethylation. | 25782871 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | LINE-1 methylation in the noncancerous gastric mucosae of gastric cancer patients was significantly higher than in cancer tissues (P = 0.0006), but significantly lower than in the gastric mucosae of the autopsied individuals (P = 0.026), suggesting the formation of epigenetic field defect in noncancerous gastric mucosae. | 25782871 |
| Infection caused by Helicobacter pylori, Stomach Carcinoma | Epigenetic Alterations | LINE-1 hypomethylation of gastric mucosae significantly correlated with H. pylori infection, supporting the potential of LINE-1 methylation level as a surrogate marker of epigenetic field defects for gastric cancer cancerization, particularly induced by H. pylori. | 25782871 |
| Triple-Negative Breast Cancer Finding, Neoplasms | Epigenetic Alterations | Here we demonstrated that epigenetic alteration of key tumor suppressor gene can be a promising biomarker for the prognosis of triple-negative breast cancer/basal-like breast cancer. | 25783183 |
| Dysplasia, SERPINB3 wt Allele | Epigenetic Alterations | The only microRNA to discriminate between OSCC and PMD with dysplasia was miRNA-184. | 25784212 |
| SERPINB3 wt Allele | Epigenetic Alterations | Conversely, miRNA-145 levels showed a highly significant decrease in OSCC and PMD overall (P < 0.001). | 25784212 |
| Oral mucosal lesions, S100A4 protein, human | Epigenetic Alterations | Salivary determination of the miRNAs tested might furnish a noninvasive, rapid adjunctive aid for revealing malignant transformation in oral mucosal lesions, particularly miRNA-184. | 25784212 |
| Primary malignant neoplasm | Epigenetic Alterations | Salivary microRNAs in oral cancer. | 25784212 |
| Barrett Esophagus | Epigenetic Alterations | Dynamic changes in microRNA expression profiles reflect progression of Barretts esophagus to esophageal adenocarcinoma. | 25784377 |
| Carcinogenesis | Epigenetic Alterations | We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barretts-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC. | 25784377 |
| Metastasis | Epigenetic Alterations | Unexpectedly, we identified that miRNA-29b expression was elevated in the serum of NPC patients with a high risk of metastasis. | 25786138 |
| Breast Carcinoma | Epigenetic Alterations | Unsupervised and supervised comparison of gene and microRNA (miRNA) profiles of Chinese and Caucasian samples revealed extensive similarity in the comprehensive taxonomy of transcriptional elements regulating breast cancer biology. | 25787708 |
| Breast Carcinoma | Epigenetic Alterations | Partition of gene expression data using gene lists relevant to breast cancer as "intrinsic" and "extracellular matrix" genes identified Chinese and Caucasian subgroups with equivalent global gene and miRNA profiles. | 25787708 |
| Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Recently, cancer relevant miRNAs deregulated during disease progression have also been identified in tumor-associated stroma.By combining laser-microdissection (LMD) with high-throughput screening and high-sensitivity quantitation techniques, miRNA expression in colorectal cancer (CRC) specimens and paired normal colonic tissue was independently characterized in stromal and epithelial tissue compartments. | 25788261 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Stratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs. | 25788261 |
| Clinical Coordinator, Phenomenon, Neoplasms | Epigenetic Alterations | Notably, deregulation of the key oncogene miR-21 was identified exclusively as a stromal phenomenon and miR-106a, an epithelial phenomenon in the malignant state.MiRNAs identified in this study successfully distinguished CRC from normal tissue and metastatic from non-metastatic tumor specimens. | 25788261 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | DFS: HR = 5.83, p = 0.002; OS: HR = 4.13, p = 0.007).These data support the notion that stromal as well as epithelial miRNAs play important roles during disease progression, and that mapping patterns of deregulated gene expression to the appropriate tumor strata may be a valuable aid to therapeutic decision making in CRC. | 25788261 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation that leads to the inactivation of tumor suppressor genes is known to play an important role in the development and progression of breast cancer. | 25789956 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small, non-coding RNAs that may function as oncogenes or tumor suppressors. | 25791131 |
| Squamous cell carcinoma | Epigenetic Alterations | Expression and clinical significance of microRNA-1246 in human oral squamous cell carcinoma. | 25791131 |
| Carcinoma, Neuroendocrine | Epigenetic Alterations | Our findings demonstrate that lung carcinoids have distinct microRNA expression profiles as compared to high-grade neuroendocrine carcinomas and that specific microRNAs might have potential implications as diagnostic tools or clinical biomarkers. | 25791280 |
| Carcinoid Tumor | Epigenetic Alterations | Identification of MicroRNAs Differentially Expressed in Lung Carcinoid Subtypes and Progression. | 25791280 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miR)-486-5p expression is often reduced in human cancers. | 25793394 |
| NRAS gene, KRAS protein, human | Epigenetic Alterations | We also tested the specimens for KRAS, NRAS, BRAF and PIK3CA mutations and measured microRNA-21 and microRNA-31. | 25797243 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways. | 25797254 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Role of microRNA-30c targeting ADAM19 in colorectal cancer. | 25799050 |
| Malignant Neoplasms, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNAs (miRNAs) are deregulated in a number of cancers including colorectal cancer. | 25799050 |
| Epilepsy, Temporal Lobe | Epigenetic Alterations | Dynamic Expression of MicroRNAs (183, 135a, 125b, 128, 30c and 27a) in the Rat Pilocarpine Model and Temporal Lobe Epilepsy Patients. | 25801837 |
| Epilepsy, Temporal Lobe | Epigenetic Alterations | Recently, microRNAs (miRNAs) are emerging as new regulators in the pathogenesis of temporal lobe epilepsy (TLE) and playing a major role in the inflammatory and immune processes. | 25801837 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. | 25803870 |
| Clinical Coordinator | Epigenetic Alterations | MicroRNAs are thought to be potential biomarkers of CRC. | 25803870 |
| Clinical Coordinator | Epigenetic Alterations | Many researchers have focused on the expression pattern of miRNAs in CRC. | 25803870 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | In all, 93 miRNAs were identified that were significantly dysregulated in Colorectal adenocarcinoma relative to normal tissues (P<0.05). | 25803870 |
| Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | Then, we analyzed their potential as cancer biomarkers by ROC analysis, and the result revealed that three miRNAs with high sensitivity and specificity are suitable as biomarkers for the diagnosis of CRC (the value of the AUC was greater than 0.7). | 25803870 |
| Malignant Neoplasms | Epigenetic Alterations | Furthermore, we wanted to analyze the difference between well- and moderately differentiated cancers, and as expected, 58 miRNAs showed significant dysregulation. | 25803870 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Importantly, 32 miRNAs were able to not only distinguish cancer tissues from normal tissues, but they were also able to identify well- and moderately differentiated cancers. | 25803870 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | To avoid misdiagnoses and missed diagnoses, tumors of different degrees of differentiation should be treated differently when miRNAs are used as cancer biomarkers. | 25803870 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers. | 25804630 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic modification of cancer cell genome is often linked to the expression of important cancer-related genes. | 25806852 |
| Clinical Coordinator | Epigenetic Alterations | Stable presence of miRNAs in serum enables them to be biomarkers for early diagnosis and surveillance of the progress of CRC. | 25807655 |
| Septicemia | Epigenetic Alterations | Recent reports on alterations in miR-223 serum levels during sepsis revealed contradictory results, preventing a potential use of this miRNA in clinical routine. | 25810564 |
| Refractory Cytopenia of Childhood, Renal Cell Carcinoma Pathway | Epigenetic Alterations | The miRNA, miR-134, has been found to be downregulated in renal cell carcinoma (RCC), but its function in the disease is unknown. | 25811077 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant microRNAs (miRNAs) are reported to contribute to the pathogenesis of most human malignancies. | 25811077 |
| Esophageal carcinoma | Epigenetic Alterations | Serum microRNA-218 is a potential biomarker for esophageal cancer. | 25812647 |
| Esophageal carcinoma | Epigenetic Alterations | The expression of microRNA-218 (miR-218) is downregulated in esophageal cancer as reported in previous research. | 25812647 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines. | 25814674 |
| Idiopathic pulmonary hypertension | Epigenetic Alterations | Role of circulating miRNAs as biomarkers in idiopathic pulmonary arterial hypertension: possible relevance of miR-23a. | 25815108 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRs) are small, endogenous noncoding RNAs that serve a significant function in various biologic processes, including those involved in cancer. | 25815587 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Upregulated microRNA-16 as an oncogene in renal cell carcinoma. | 25815587 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation combinations in adjacent normal colon tissue predict cancer recurrence: evidence from a clinical cohort study. | 25815725 |
| Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | We evaluate the combination of cancer stage and DNA methylation status as an indicator of the risk of recurrence and mortality among patients with colorectal cancer (CRC). | 25815725 |
| Neoplasms | Epigenetic Alterations | For combined analyses, the risk of recurrence in the patients in advanced stage with DNA methylation in both normal and tumor tissues, compared with local stage with unmethylation, was increased with adjusted HR (95% CI) of 9.37 (3.36-26.09). | 25815725 |
| Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | This study demonstrates that clustering DNA methylation status according to cancer stage and tissue subtype is critical for the assessment of risk of recurrence in CRC patients and also indicated an underlying mechanism. | 25815725 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | DNA methylation consistency implicates the primary tumor cell origin of recurrent hepatocellular carcinoma. | 25815780 |
| Neoplasms | Epigenetic Alterations | Similar DNA methylation patterns were observed among nine of ten pairs of primary and recurrent tumors. | 25815780 |
| Liver diseases | Epigenetic Alterations | Serum microRNA-125a-5p, a useful biomarker in liver diseases, correlates with disease progression. | 25815788 |
| Liver carcinoma, Liver diseases, Hollings Cancer Center, Fibrosis Assessment | Epigenetic Alterations | It has been demonstrated that liver microRNA-125a-5p (miR-125a-5p) is correlated with disease progression in different liver diseases, including liver fibrosis and hepatocellular carcinoma (HCC). | 25815788 |
| Admitting diagnosis | Epigenetic Alterations | The epigenetic mechanism of BDNF methylation may be responsible for the reduced expression of BDNF in patients with AD. | 25815896 |
| Diabetes Mellitus, Non-Insulin-Dependent, square decimeter | Epigenetic Alterations | MicroRNA-103 (miR-103) plays a critical role in regulating glucose homeostasis in type 2 diabetes (DM2). | 25820527 |
| Neoplasms | Epigenetic Alterations | However, the proliferation rate of tumor cells was reduced in the absence of RORgt-dependent Th17 cells and tumor cells showed pronounced signs of senescence-associated epigenetic and lysosomal changes. | 25820779 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic mechanisms such as DNA methylation are being increasingly recognized to play an important role in cancer and may serve as a cancer biomarker. | 25820821 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelomonocytic, Chronic | Epigenetic Alterations | Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic modifiers and aberrant DNA methylation. | 25822018 |
| Primary malignant neoplasm | Epigenetic Alterations | Nuclear corepressor (NCoR) is an essential regulator of gene transcription, and its function has been found deregulated in different types of cancer. | 25823659 |
| Chordoma | Epigenetic Alterations | MicroRNA-155 expression is independently predictive of outcome in chordoma. | 25823817 |
| Chordoma | Epigenetic Alterations | The miRNA microarray assay revealed miR-155 to be highly expressed and biologically active in chordoma. | 25823817 |
| Breast Carcinoma | Epigenetic Alterations | Loss of expression of cyclin d2 by aberrant DNA methylation: a potential biomarker in vietnamese breast cancer patients. | 25824739 |
| cell transformation, Neoplasms | Epigenetic Alterations | DNA methylation of tumor suppressor gene promoters is the most frequent phenomenon leading to inactivation of function, consequently driving malignant cell transformation. | 25824739 |
| Endometrial Carcinoma | Epigenetic Alterations | Urine has been shown as the source of microRNAs several years ago; however, there has been lack of information on urine microRNA expression in ovarian and endometrial cancers till now. | 25827090 |
| Endometrial Carcinoma | Epigenetic Alterations | Evaluation of Cell-Free Urine microRNAs Expression for the Use in Diagnosis of Ovarian and Endometrial Cancers. | 25827090 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is an important epigenetic modification that is frequently altered in cancer. | 25827305 |
| ovarian neoplasm | Epigenetic Alterations | The influence of DNA methylation in epithelial ovarian cancer (EOC) is not fully understood. | 25827305 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | DNA methylation occurs commonly in non-small cell lung cancer (NSCLC). | 25828518 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | CHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer. | 25828518 |
| Psoriatic Juvenile Idiopathic Arthritis | Epigenetic Alterations | Correlation between Reversal of DNA Methylation and Clinical Symptoms in Psoriatic Epidermis Following Narrow-Band UVB Phototherapy. | 25830654 |
| Psoriasis | Epigenetic Alterations | Genome-wide DNA methylation profiling of epidermal cells from 12 patients undergoing narrow-band UVB phototherapy and 12 corresponding healthy controls revealed a distinct DNA methylation pattern in psoriasis compared with controls. | 25830654 |
| Psoriasis | Epigenetic Alterations | Our study identified key epigenetic events associated with psoriasis pathogenesis and helps understand the dynamic DNA methylation landscape in the human genome. | 25830654 |
| Liver carcinoma, Cholangiocarcinoma | Epigenetic Alterations | Global DNA methylation and hydroxymethylation differ in hepatocellular carcinoma and cholangiocarcinoma and relate to survival rate. | 25833413 |
| Primary malignant neoplasm | Epigenetic Alterations | microRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression. | 25833694 |
| Weight decreased, Breast Carcinoma | Epigenetic Alterations | Dietary modifications, weight loss, and changes in metabolic markers affect global DNA methylation in Hispanic, African American, and Afro-Caribbean breast cancer survivors. | 25833781 |
| Primary malignant neoplasm | Epigenetic Alterations | Lower levels of global DNA methylation in tissue and blood have been associated with increased cancer risk. | 25833781 |
| Weight decreased | Epigenetic Alterations | In this trial, we explored the associations between changes in lifestyle modifications (diet, weight loss), metabolic markers, and global epigenetic biomarkers in white blood cells. | 25833781 |
| Primary malignant neoplasm | Epigenetic Alterations | An increasing body of evidence has indicated that polymorphisms in the miRNA binding site of target gene can alter the ability of miRNAs to bind their target genes and modulate the risk of cancer. | 25834816 |
| Stomach Carcinoma | Epigenetic Alterations | Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer. | 25835973 |
| Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) are emerging as novel regulators in the cancer paradigm. | 25835973 |
| Degenerative polyarthritis, Arthritis, Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Single-nucleotide polymorphisms (SNPs) in miRNA sequences may alter miRNA expression and have been implicated in the pathogenesis of multiple forms of arthritis, including rheumatoid arthritis (RA) and osteoarthritis. | 25836258 |
| Breast Carcinoma | Epigenetic Alterations | Global Transcriptional Changes Following Statin Treatment in Breast Cancer. | 25840970 |
| ovarian neoplasm | Epigenetic Alterations | Long non-coding RNA ANRIL predicts poor prognosis and promotes invasion/metastasis in serous ovarian cancer. | 25845387 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Screening and preliminary validation of miRNAs with the regulation of hTERT in colorectal cancer. | 25845814 |
| Clinical Coordinator | Epigenetic Alterations | The expression of miRNAs candidates was verified by quantitative polymerase chain reaction in the CRC and corresponding normal tissues. | 25845814 |
| Conventional (Clear Cell) Renal Cell Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W. Increasing evidence has demonstrated that small non-coding microRNAs (miRNAs) play important roles in cancer development and progression. | 25846734 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation is an epigenetic event that occurs frequently in colorectal cancer (CRC). | 25846879 |
| Atypical Reparative Cell | Epigenetic Alterations | DNA methylation of MGMT may regulate the expression of the gene and be involved in the development of ARC. | 25847269 |
| Primary malignant neoplasm | Epigenetic Alterations | Bioinformatical analysis revealed that the potential target genes of these miRNAs were mainly involved in gene transcription, cell junction proteins, and gene pathways in cancer and endocytosis. | 25850393 |
| Chordoma | Epigenetic Alterations | Reduced expression of miRNA-1237-3p associated with poor survival of spinal chordoma patients. | 25850393 |
| Chordoma | Epigenetic Alterations | A miRNA array was used to profile differentially expressed miRNAs in spinal chordoma and nucleus pulposus tissues. | 25850393 |
| Chordoma | Epigenetic Alterations | The miRNA arrays identified 29 differentially expressed miRNAs in spinal chordoma tissues, four of which were verified by qRT-PCR in 42 spinal chordomas and 14 control tissues. | 25850393 |
| Chordoma | Epigenetic Alterations | Four of these differentially expressed miRNAs was then validated in spinal chordoma and control patients using quantitative RT-PCR. | 25850393 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The serum free deoxyribose nucleic acid (DNA) methylation spectrum of EOC patients was completely contained in the DNA spectrum of cancer tissues, providing an accurate reflection of tumor DNA methylation conditions. | 25854397 |
| Coronary Artery Disease | Epigenetic Alterations | A comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease. | 25856389 |
| Arteriosclerosis | Epigenetic Alterations | So far, our current knowledge of the DNA methylation profiles for atherosclerosis affected and healthy human vascular tissues is still limited. | 25856389 |
| Coronary Artery Disease | Epigenetic Alterations | The DNA methylation differences observed in vascular tissues of patients with coronary heart disease can provide new insights into the mechanisms underlying the development of pathology and explanation for the difference in graft patency after coronary artery bypass grafting surgery. | 25856389 |
| Cardiovascular Diseases | Epigenetic Alterations | Epigenetic mechanisms of gene regulation in context of cardiovascular diseases are of considerable interest. | 25856389 |
| Schizophrenia, Bipolar Disorder, Mental disorders, Primary malignant neoplasm | Epigenetic Alterations | Recent evidence supports a role of microRNAs in cancer and psychiatric disorders such as schizophrenia and bipolar disorder, through their regulatory role on the expression of multiple genes. | 25856466 |
| Schizophrenia, Mental disorders, Primary malignant neoplasm | Epigenetic Alterations | The rather rare co-morbidity of cancer and schizophrenia is an old hypothesis which needs further research on microRNAs as molecules that might exert their oncosuppressive or oncogenic activity in the context of their role in psychiatric disorders. | 25856466 |
| Gain | Epigenetic Alterations | Targeting miRNAs by gain or loss of function approaches have brought therapeutic effects in various disease models. | 25860297 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic modification plays pivotal roles in gastric cancer development. | 25860861 |
| Stomach Carcinoma | Epigenetic Alterations | Interference with the b-catenin gene in gastric cancer induces changes to the miRNA expression profile. | 25861021 |
| Gallbladder Carcinoma | Epigenetic Alterations | Thus, the miRNA profiles could play essential roles in gallbladder cancer (GBC). | 25861754 |
| Neoplasms | Epigenetic Alterations | Our results suggest a possible pathological relationship between the differential expression of miRNA in peripheral blood and GBC, and these dysregulated miRNAs could be novel tumor biomarkers for early detection of GBC. | 25861754 |
| Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Primary malignant neoplasm | Epigenetic Alterations | Our results highlight the impact of age, BMI and HbA1c on epigenetic variation of candidate genes for obesity, type 2 diabetes and cancer in human adipose tissue. | 25861810 |
| Metastasis, Pituitary carcinoma | Epigenetic Alterations | Our results suggest microRNA involvement in malignant pituitary progression, whereby increased miR-20a, miR-106b and miR-17-5p promote metastasis by attenuating PTEN and TIMP2 in pituitary carcinoma. | 25862551 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Non-small cell lung cancer detection using microRNA expression profiling of bronchoalveolar lavage fluid and sputum. | 25862841 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | To assess if miRNA expression profiling of bronchoalveolar lavage (BAL) fluid and sputum could be used to detect early-stage non-small cell lung cancer (NSCLC). | 25862841 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC. | 25862841 |
| Lymphadenitis | Epigenetic Alterations | As a first step towards understanding the possible influence of microRNA-dysregulation in AITL, we analyzed the expression signatures of 760 microRNAs in 30 nodal AITLs in comparison to reactive lymphadenitis with T-zone hyperplasia. | 25862860 |
| Angioimmunoblastic Lymphadenopathy | Epigenetic Alterations | Dysregulation of microRNAs in angioimmunoblastic T-cell lymphoma. | 25862860 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | MicroRNA profile in site-specific head and neck squamous cell cancer. | 25862914 |
| Oropharyngeal Route of Drug Administration | Epigenetic Alterations | The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. | 25862914 |
| Bone Diseases | Epigenetic Alterations | Accumulating evidence has recently indicated a vital role of microRNAs (miRNAs) in the development of various bone diseases. | 25863178 |
| Metastasis, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma. | 25863539 |
| Neoplasms | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have emerged as key regulators of tumor development and progression. | 25863539 |
| B-Cell Lymphomas | Epigenetic Alterations | Upregulation of long noncoding RNA PEG10 associates with poor prognosis in diffuse large B cell lymphoma with facilitating tumorigenicity. | 25864113 |
| Initiation | Epigenetic Alterations | Emerging evidences have implicated that long noncoding RNAs (lncRNAs) have important regulatory roles in fundamental biological processes, and some of them are involved in cancer initiation, development and progression. | 25864113 |
| Breast Carcinoma | Epigenetic Alterations | Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer. | 25865225 |
| Breast Carcinoma, Mammary Neoplasms | Epigenetic Alterations | Evaluating this long non-coding RNA in breast tumors may have prognostic and predictive value in the clinical management of breast cancer. | 25865225 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | To compare microRNA (miR) expression between patients with diffuse large B-cell lymphoma (DLBCL) who had a poor prognosis to those who had a favorable prognosis. | 25866097 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA expression signatures can promote personalised care for non-small cell lung cancer (NSCLC) patients. | 25867273 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | C/EBP-b-activated microRNA-223 promotes tumour growth through targeting RASA1 in human colorectal cancer. | 25867276 |
| melanoma | Epigenetic Alterations | We analyzed the effect of cordycepin on human melanoma miRNA expression profiles by miRNAarray and found that miR-33b was upregulated in highly-metastatic melanoma cell lines following cordycepin exposure. | 25868853 |
| melanoma, Neoplasm Metastasis | Epigenetic Alterations | We showed for the first time that targeting miRNA by cordycepin indicates a new mechanism of cordycepin-induced suppression of tumor metastasis and miR-33b/HMGA2/Twist1/ZEB1 axis plays critical roles in regulating melanoma dissemination. | 25868853 |
| Occult Lung Non-Small Cell Carcinoma | Epigenetic Alterations | Prognostic value of microRNA-10b overexpression in peripheral blood mononuclear cells of nonsmall-cell lung cancer patients. | 25869877 |
| Occult Lung Non-Small Cell Carcinoma, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We examined microRNA (miRNA)-10b expression in peripheral blood mononuclear cells (PBMCs) of nonsmall-cell lung cancer (NSCLC) patients for its clinical value. | 25869877 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The correlation between miRNA-10b expression levels and the clinical and pathological characteristics of NSCLC was obtained. | 25869877 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MiRNA-10b expression levels in PBMCs can distinguish NSCLC patients from cancer-free subjects with a high sensitivity and specificity, suggesting that miRNA-10b expression in PBMCs is a valuable diagnostic and prognostic marker in NSCLC. | 25869877 |
| Acute intermittent porphyria | Epigenetic Alterations | Our results identified that miRNAs were differentially expressed in the serum of AIP patients. | 25871699 |
| Platinum-Resistant Ovarian Carcinoma, ovarian neoplasm | Epigenetic Alterations | MicroRNA signatures of platinum-resistance in ovarian cancer. | 25872328 |
| ovarian neoplasm | Epigenetic Alterations | The authors utilized a microRNA (miRNA) array to compare the differentially expressed miRNAs in platinum-resistant associated ovarian cancer cells. | 25872328 |
| ovarian neoplasm | Epigenetic Alterations | The authors identified that several miRNAs are altered in collected 86 samples of human ovarian cancer cell-lines, with four significantly deregulated miRNAs and 13 upregulated miRNAs. | 25872328 |
| Malignant Neoplasms, Late stage, Metastasis | Epigenetic Alterations | As patient survival drops precipitously from early-stage cancers to late-stage and metastatic cancers, microRNAs that promote relapse and metastasis can serve as prognostic and predictive markers as well as therapeutic targets for chemoprevention. | 25872451 |
| Prostate Cancer Pathway | Epigenetic Alterations | Elevated serum microRNA levels associate with absence of high-grade prostate cancer in a retrospective cohort. | 25874774 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Circulating microRNAs (miRNAs) are stable serum markers and differential miRNA levels occur in men with PCa. | 25874774 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The expression levels of the 14 miRNAs were combined into a "miR Score" which had a negative predictive value (NPV) of 0.939 to predict absence of high-grade PCa among PCa and BPH patients. | 25874774 |
| Aggressive behavior | Epigenetic Alterations | In summary, measurement of serum miRNAs may have pre-surgical utility in combination with clinical risk calculators to identify patients with low risk of harboring aggressive PCa. | 25874774 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-138-5p regulates pancreatic cancer cell growth through targeting FOXC1. | 25875420 |
| Neoplasm Metastasis | Epigenetic Alterations | Enhancer of zeste homolog 2 (EZH2), a polycomb histone methyltransferase, is a key epigenetic modifier implicated in various cancer metastasis. | 25877750 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL. | 25880332 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | However, there is no evidence of the pathogenetic mechanism of this miRNA in CLL patients. | 25880332 |
| Malignant Neoplasms, cervical cancer | Epigenetic Alterations | Our observations provide an important cautionary tale for future miRNA signature studies for cervical cancer, which can also be potentially applicable to miRNA profiling studies involving other types of human malignancies. | 25880806 |
| Cervix carcinoma | Epigenetic Alterations | Developing a prognostic micro-RNA signature for human cervical carcinoma. | 25880806 |
| cervical cancer | Epigenetic Alterations | We sought to develop a micro-RNA signature that was prognostic for disease-free survival, which could potentially allow tailoring of treatment for cervical cancer patients. | 25880806 |
| cervical cancer, Neoplasms | Epigenetic Alterations | There are several challenges and considerations associated with developing a prognostic micro-RNA signature for cervical cancer, namely: tumour heterogeneity, lack of concordance between frozen and FFPE specimens, and platform selection for global micro-RNA expression profiling in this disease. | 25880806 |
| Intrahepatic Cholangiocarcinoma | Epigenetic Alterations | Identification of a novel microRNA signature associated with intrahepatic cholangiocarcinoma (ICC) patient prognosis. | 25880914 |
| Intrahepatic bile duct, Development International Birth Date | Epigenetic Alterations | Using a custom microarray containing 1,094 probes, the miRNA expression profiles of 63 human ICCs and nine normal intrahepatic bile ducts (NIBD) were assessed. | 25880914 |
| Development International Birth Date | Epigenetic Alterations | From the 158 differentially expressed miRNAs, a 30-miRNA signature consisting of 10 up-regulated and 20 down-regulated miRNAs in ICC was established for distinguishing ICC from NIBD with 100% accuracy. | 25880914 |
| Intrahepatic Cholangiocarcinoma | Epigenetic Alterations | The clinical significance of microRNAs (miRNAs) in intrahepatic cholangiocarcinoma (ICC) is unclear. | 25880914 |
| Development International Birth Date | Epigenetic Alterations | Expression profile analysis showed 158 differentially expressed miRNAs between ICC and NIBD, with 77 up-regulated and 81 down-regulated miRNAs. | 25880914 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3. | 25881295 |
| Coronary Artery Disease | Epigenetic Alterations | An Association between MicroRNA-21 Expression and Vitamin D Deficiency in Coronary Artery Disease. | 25882990 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | microRNA (miRNA) and protein expression profiles were obtained from 71 estrogen receptor-positive (ER(+)) and 25 triple-negative breast cancer (TNBC) samples. | 25883093 |
| Breast Carcinoma | Epigenetic Alterations | The integration of miRNA and protein expression data unravels molecular processes that can be related to differences in the genesis and clinical evolution of these types of breast cancer. | 25883093 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Loss of expression of miRNA-141 and miRNA-200b was associated with increased invasion and migration ability, upregulated MMP-2, MMP-9, vimentin and N-cadherin expression, and downregulated E-cadherin expression in bladder cancer cell lines. | 25884322 |
| Metastasis | Epigenetic Alterations | Urine miRNA-141 and miRNA-200b levels could discriminate patients with lymph node metastasis from those who were lymph node negative (AUC: 0.704 and 0.674, respectively). | 25884322 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MiRNA-141 and miRNA-200b play important roles in the invasive ability and EMT phenotype of bladder cancer. | 25884322 |
| Metastasis | Epigenetic Alterations | Detection of miRNA-141 and miRNA-200b can help to identify patients undergoing cystectomy who are likely to have lymph node metastasis, and therefore those who may benefit from super-extended PLND. | 25884322 |
| Liver carcinoma | Epigenetic Alterations | Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge. | 25884472 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have been identified as having functional roles in cancer biology and are deregulated in many cancers. | 25884472 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. | 25885099 |
| melanoma | Epigenetic Alterations | Our genome-wide DNA methylation and gene expression study of 10 early passage melanoma cell cultures reveals two phenotypically distinct groups. | 25885555 |
| ibudilast | Epigenetic Alterations | The role of microRNAs (miRNAs), noncoding RNAs involved in regulating numerous biological processes, to IBD pathology, in terms of initiation and progression, remains ill-defined. | 25886994 |
| Ulcerative Colitis, Crohn Disease | Epigenetic Alterations | MicroRNA signatures differentiate Crohns disease from ulcerative colitis. | 25886994 |
| Ulcerative Colitis | Epigenetic Alterations | Our results suggest that there is specific miRNA expression patterns associated with UC versus CD in three separate tissue/body fluids (colon, blood, and saliva). | 25886994 |
| ibudilast, Inflammation | Epigenetic Alterations | Further, the aberrant miRNA expression profiles indicate that miRNAs may be contributory to IBD pathogenesis, or at least reflect the underlying inflammation. | 25886994 |
| ibudilast | Epigenetic Alterations | Scrutinizing miRNA expression in saliva and blood samples may be beneficial in monitoring or diagnosing disease in IBD patients. | 25886994 |
| Ulcerative Colitis | Epigenetic Alterations | CD was associated with the differential expression of 10 miRNAs while UC was associated with 6 miRNAs in matched colon tissues. | 25886994 |
| Ulcerative Colitis | Epigenetic Alterations | CD was associated with altered expression of 6 miRNAs while UC was associated with 9 miRNAs in whole blood. | 25886994 |
| Ulcerative Colitis | Epigenetic Alterations | A panel of miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-146a, and miR-375) may be used as markers to identify and discriminate between CD and UC. | 25886994 |
| Carcinoma, Ovarian Epithelial | Epigenetic Alterations | miRNA-1307 was up-regulated in the chemoresistant epithelial ovarian cancer tissues compared to the chemosensitive counterparts. | 25887170 |
| ovarian neoplasm, Metastasis, Neoplasms | Epigenetic Alterations | The up-regulation of miRNA-1307 was not associated with menopause, tumor differentiation state, clinical stage, and lymph node metastasis of ovarian cancer. | 25887170 |
| ovarian neoplasm | Epigenetic Alterations | Our results suggest that miRNA-1307 may play a role in the development of chemoresistance in ovarian cancer. | 25887170 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | Long non-coding RNA expression profiles predict metastasis in lymph node-negative breast cancer independently of traditional prognostic markers. | 25887545 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-184 inhibits cell proliferation and invasion, and specifically targets TNFAIP2 in Glioma. | 25888093 |
| Squamous cell carcinoma, Liver carcinoma, Neoplasms | Epigenetic Alterations | miRNA-184 is an oncogene in human hepatocellular carcinoma but acts as a tumor suppressor in tongue squamous cell carcinoma. | 25888093 |
| Paresis | Epigenetic Alterations | We hypothesised that certain plasma microRNAs could be biomarkers of ICU acquired muscle weakness. | 25888214 |
| Carcinogenesis | Epigenetic Alterations | Dysregulation of microRNAs (miRs) is involved in carcinogenesis. | 25888635 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are short, non-coding RNA molecules that play critical roles in human malignancy. | 25888956 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | Our work delivers a clear picture of the global miRNA regulatory characteristics in triple-negative breast cancer and extends the current knowledge of microRNA regulatory network. | 25888956 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | We documented the evidence of seven polycistronic miRNA clusters preferentially harboring deregulated miRNAs in triple-negative breast cancer. | 25888956 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | Two of these miRNA clusters (miR-143-145 at 5q32 and miR-497-195 at 17p13.1) were markedly down-regulated in triple-negative breast cancer, while the other five miRNA clusters (miR-17-92 at 13q31.3, miR-183-182 at 7q32.2, miR-200-429 at 1p36.33, miR-301b-130b at 22q11.21, and miR-532-502 at Xp11.23) were up-regulated in triple-negative breast cancer. | 25888956 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing. | 25888956 |
| Breast Carcinoma, Triple-Negative Breast Cancer Finding | Epigenetic Alterations | However, the regulatory characteristics of miRNAs in triple-negative breast cancer, a phenotype of breast cancer that does not express the genes for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are still poorly understood. | 25888956 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | Deregulated miRNAs in triple-negative breast cancer were identified from the sequencing data using the Students t-test. | 25888956 |
| Primary malignant neoplasm | Epigenetic Alterations | Validated molecular targets of the deregulated miRNAs were retrieved from curated databases and their associations with cancer progression were discussed. | 25888956 |
| Plaque (lesion) | Epigenetic Alterations | The data showed target genes regulated by these statin induced miRNAs majorly expressed in i) plaque macrophage and platelet, where they were involved in hemostasis process; ii) in monocyte to regulate NGF apoptosis; iii) and in endothelial cell function in Rho GTPase pathway. | 25889164 |
| Hodgkin Disease, Huntington Disease, Neurodegenerative Disorders | Epigenetic Alterations | In Huntingtons disease (HD), a neurodegenerative disease caused by a trinucleotide repeat expansion, miRNA dyregulation has been reported, which may impact gene expression and modify the progression and severity of HD. | 25889241 |
| Hodgkin Disease | Epigenetic Alterations | The miRNAs identified in our studies of postmortem brain tissue may be detectable in peripheral fluids and thus warrant consideration as accessible biomarkers for disease stage, rate of progression, and other important clinical characteristics of HD. | 25889241 |
| Liver carcinoma | Epigenetic Alterations | TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma. | 25889455 |
| Malignant Neoplasms, Hollings Cancer Center | Epigenetic Alterations | As epigenetic changes are considered possible surrogates to mutations in human cancers, we decided, thus, to characterize DNA methylation in HCC from North-African patients. | 25889455 |
| Carcinoma | Epigenetic Alterations | More importantly, DNA methylation was significantly higher in Arg/Arg when compared to Pro/Pro genotype carriers at codon 72 rs1042522 of TP53 (65% vs 20% methylated loci, p = 0.0006), a polymorphism already known to affect somatic mutation rate in human carcinomas. | 25889455 |
| Hollings Cancer Center | Epigenetic Alterations | Our data suggest that Arg72Pro polymorphism in a WT p53 context may act as a primary driver of epigenetic changes in HCC. | 25889455 |
| Carcinogenesis, Hollings Cancer Center | Epigenetic Alterations | This model of liver tumorigenesis that associates low penetrance genetic predisposition to epigenetic changes emerges from a region of low HCC incidence and it may, therefore, apply essentially to population living in similar areas. | 25889455 |
| Carcinoma of lung, Metastasis | Epigenetic Alterations | Increased expression of the long non-coding RNA ANRIL promotes lung cancer cell metastasis and correlates with poor prognosis. | 25889788 |
| Primary malignant neoplasm | Epigenetic Alterations | Emerging evidences indicate that dysregulated long non-coding RNAs (lncRNAs) are implicated in cancer tumorigenesis and progression. | 25889788 |
| Malignant Neoplasms, Neoplasms, Refractory Cytopenia of Childhood | Epigenetic Alterations | Increasing evidence has shown that microRNAs function as oncogenes or tumor suppressors in human malignancies, but the roles of miR-203 in human RCC is still unclear. | 25890121 |
| Epilepsy, Inflammation, Seizures | Epigenetic Alterations | Recently, a growing body of evidence has suggested that microRNA-146a (miR-146a) is upregulated in the brains of epilepsy patients and of mouse models; furthermore, miR-146a may be involved in the development and progression of seizures through the regulation of inflammation and immune responses. | 25891929 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | Accumulation of epigenetic alterations causes inactivation of tumor suppressors and contributes to the initiation and progression of hepatocellular carcinoma (HCC). | 25892360 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs are frequently altered in numerous cancers and are critical regulators of various diseases. | 25894339 |
| Carcinoma of lung, Retinoblastoma, Metastasis, melanoma | Epigenetic Alterations | Recent evidence shows that BRAF-activated non-coding RNA (BANCR) acts as a critical role in the proliferation and metastasis in malignant melanoma and lung cancer; however, little is known about the significance of lncRNA BANCR in retinoblastoma. | 25894373 |
| Chronic liver disease, Liver carcinoma | Epigenetic Alterations | Plasma microRNA might as a potential biomarker for hepatocellular carcinoma and chronic liver disease screening. | 25894380 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Long non-coding RNA LINC01296 is a potential prognostic biomarker in patients with colorectal cancer. | 25894381 |
| Malignant tumor of colon | Epigenetic Alterations | Increased microRNA-34b and -34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancer. | 25894979 |
| Neoplasms | Epigenetic Alterations | The microRNA-34 family (miR-34a, -34b and -34c) have been reported to be tumor suppressor microRNAs (miRNAs) that are regulated by the TP53 and DNA hypermethylation. | 25894979 |
| Colonic Neoplasms, Neoplasms | Epigenetic Alterations | All miR-34 family members were significantly increased in colon tumors, counter to the proposed tumor suppressor role for these miRNAs. | 25894979 |
| ovarian neoplasm | Epigenetic Alterations | A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ. | 25895125 |
| Primary malignant neoplasm | Epigenetic Alterations | The involvement of microRNA in cancer progression has recently been reported, though whether they have a role in activating YAP and TAZ in human cancer cells remains unclear. | 25895125 |
| Clinical Coordinator | Epigenetic Alterations | MiRNA-145 and miRNA-378* are potential biomarkers for early detection of CRC, which may help in diagnosing CRC in early period. | 25896668 |
| Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Although microRNAs offer great potential as cancer biomarkers, effective clinical dignostics and tumor maker have not been verified to diagnose with colorectal cancer (CRC). | 25896668 |
| Clinical Coordinator | Epigenetic Alterations | Using enter and stepwise variable selection methods separately, conditional logistic regression was conducted to identify miRNAs associated with CRC. | 25896668 |
| Clinical Coordinator | Epigenetic Alterations | In this study, we confirmed 11 overexpressed miRNAs with no less than twofold difference, and 85 downexpressed miRNAs with up to 0.5-fold difference in CRC from 96 aberrantly expressed miRNAs being identified by real-time PCR. | 25896668 |
| Neoplasm Metastasis | Epigenetic Alterations | HOX transcript antisense RNA (HOTAIR), a long intergenic non-coding RNA (lncRNA), functions as a molecular scaffold to link and target the histone modification complexes PRC2 and LSD1, then reprograms chromatin states by coupling histone H3K27 methylation and H3K4 demethylation for epigenetic gene silencing to promote cancer metastasis. | 25901533 |
| Inflammation | Epigenetic Alterations | Thus, these results provide an additional line of evidence that IWT is advantageous in promoting health from an epigenetic perspective by ameliorating susceptibility to inflammation. | 25901949 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumor suppressor genes is involved in early transforming events and has a high impact on colorectal carcinogenesis. | 25902909 |
| Malignant tumor of colon, Intestinal Diseases | Epigenetic Alterations | Likewise, colon cancers that derive from chronically inflamed bowel diseases frequently exhibit epigenetic changes. | 25902909 |
| Colorectal Cancer Pathway | Epigenetic Alterations | But there is little data about epigenetic aberrations causing colorectal cancer in chronically inflamed tissue. | 25902909 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MiR-133a serves as a tumor-suppressive miRNA in human NSCLC, and its downregulation suggests deterioration in NSCLC patients. | 25903369 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | Epigenetic regulation of the novel tumor suppressor cysteine dioxygenase 1 in esophageal squamous cell carcinoma. | 25903467 |
| Head and Neck Neoplasms | Epigenetic Alterations | To expand our currently sparse knowledge of the noncoding alterations involved in the disease and identify potential biomarkers and therapeutic targets, we globally profiled the dysregulation of small nucleolar and long noncoding RNAs in head and neck tumors. | 25904139 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | We confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration. | 25904139 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | As a whole, noncoding RNAs are pervasively dysregulated in head and squamous cell carcinoma. | 25904139 |
| Borderline Personality Disorder, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The expression of all three miRNAs were significantly lower in the serum of NSCLC than that of BPD and healthy controls (all p<0.01), and their expression levels were strongly correlated with each other (r=0.781, 0.720, and 0.645, respectively). | 25904302 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | Circulating cell-free miRNAs as biomarker for triple-negative breast cancer. | 25906045 |
| Pancreatic carcinoma | Epigenetic Alterations | We found a prediction model for postoperative prognosis of pancreatic cancer using 7 microRNA expression patterns from archived formalin-fixed paraffin-embedded surgical specimens. | 25906450 |
| Pancreatic carcinoma | Epigenetic Alterations | Postoperative prognosis prediction of pancreatic cancer with seven microRNAs. | 25906450 |
| Malignant Neoplasms | Epigenetic Alterations | MiRNAs are a class of short noncoding RNAs that regulate mRNAs at posttranscriptional level and are deregulated in various human malignancies. | 25907662 |
| Breast Carcinoma | Epigenetic Alterations | In particular, microRNA (miRNA) has attracted the interest of both basic and clinical investigators as one of the promising molecular markers of breast cancer patients. | 25907662 |
| Breast Carcinoma | Epigenetic Alterations | Correlation of miRNA expression profiling in surgical pathology materials, with Ki-67, HER2, ER and PR in breast cancer patients. | 25907662 |
| Neoplasms | Epigenetic Alterations | For instance, an abundant expression of multiple let-7 miRNA family, also known as tumor suppressor, was detected in low Ki-67 and HER2 groups. | 25907662 |
| Malignant Neoplasms, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Altered expression of microRNAs has been reported in wide range of malignancies, including pancreatic ductal adenocarcinoma. | 25908274 |
| Metastasis, Neoplasms | Epigenetic Alterations | Our findings suggest that DNA methylation is a useful marker for tumor progression monitoring and that promoter methylation in certain genes is associated with more advanced tumor stage, poor differentiation, and metastasis. | 25908636 |
| Clinical Coordinator | Epigenetic Alterations | CRC development is the result of genetic and epigenetic alterations accumulation in the epithelial cells of colon mucosa. | 25908636 |
| Liver carcinoma | Epigenetic Alterations | Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU. | 25909168 |
| B-Cell Lymphomas | Epigenetic Alterations | MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma. | 25909227 |
| Diffuse Large B-Cell Lymphoma, Neoplasms | Epigenetic Alterations | The results of this study show that, in contrast to solid tumors, the frequency of GADD45g methylation is higher and this epigenetic alteration of GADD45g may be associated with progression in DLBCL. | 25912017 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | MicroRNA-129-5p inhibits hepatocellular carcinoma cell metastasis and invasion via targeting ETS1. | 25912876 |
| Neoplasms | Epigenetic Alterations | Moreover, the expression of tumor suppressor microRNA-145 (miR-145) was negatively correlated with RAD18 expression in CRC tissues of 140 patients. | 25913620 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Expression of circulating microRNA-20a and let-7a in esophageal squamous cell carcinoma. | 25914476 |
| Prostatic Hyperplasia | Epigenetic Alterations | Our findings suggest an individualized epigenetic signature for symptomatic benign prostatic hyperplasia, which may be important to choose appropriate personalized treatment options. | 25916673 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Plasma microRNAs serve as potential biomarkers for abdominal aortic aneurysm. | 25916817 |
| Thyroid Gland Follicular Adenoma | Epigenetic Alterations | microRNA expression in autonomous thyroid adenomas: Correlation with mRNA regulation. | 25916957 |
| Neoplasms | Epigenetic Alterations | The global miRNA profiles were not greatly modified, confirming the definition of these tumors as minimal deviation tumors. | 25916957 |
| Neoplasms | Epigenetic Alterations | These results support a role for miRNA in the regulation of extracellular matrix proteins and tissue remodeling occurring during tumor development, and in the important negative feedback of the cAMP pathway, which limits the consequences of its constitutive activation in these tumors. | 25916957 |
| Neoplasms | Epigenetic Alterations | Twelve miRNAs were downregulated and one was upregulated in the tumors. | 25916957 |
| Carcinoma of lung | Epigenetic Alterations | However the effect of miRNA in lung cancer chemoresistance is poorly understood. | 25917317 |
| Carcinoma of lung, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Taken together our findings imply that the miRNAs miR-205 and miR-218 play a key role in the development of lung cancer acquired chemoresistance and the tumor suppressor role of miR-218 in inhibiting lung cancer cell tumorigenesis and overcoming platinum chemoresistance is significant for future cancer therapeutic approaches. | 25917317 |
| Malignant tumor of colon | Epigenetic Alterations | We hypothesize that CLU gene is regulated by DNA methylation and histone modifications and clusterin plays an important role in colon cancer. | 25917404 |
| Malignant tumor of colon | Epigenetic Alterations | Clusterin gene is predominantly regulated by histone modifications in human colon cancer and ectopic expression of the nuclear isoform induces cell death. | 25917404 |
| Cancer-Related Death | Epigenetic Alterations | Ectopic expression of nCLU either by epigenetic modulators or by nCLU transfection is responsible for colon cancer cell death. | 25917404 |
| Malignant neoplasm of urinary bladder, Forecast of outcome | Epigenetic Alterations | Correlation of Increased Expression of MicroRNA-155 in Bladder Cancer and Prognosis. | 25918190 |
| Hepatocarcinogenesis, Hepatitis, Chronic | Epigenetic Alterations | Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis. | 25918251 |
| Prostate Cancer Pathway | Epigenetic Alterations | The molecular mechanisms involved in androgen receptor (AR) signaling pathways are not completely understood, and deregulation of microRNAs (miRNAs) expression may play a role in prostate cancer (PC) development and progression. | 25920548 |
| Stomach Carcinoma, Stage I Esophageal Squamous Cell Carcinoma AJCC v7, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Populations in north central China are at high risk for oesophageal squamous cell carcinoma (ESCC) and gastric cancer (GC), and genetic variation in epigenetic machinery genes and pathways may contribute to this risk. | 25921222 |
| Malignant Neoplasms, Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | MicroRNA expression profiling revealed thatsome oncogenic microRNAsincluding miR-155 and miR-126 were up-regulated, whilst anti-oncogenic microRNAsincluding miR-148a and miR-193a were down-regulated in MAPKBP1high patients with CN-AML, which may underlie the pathological processes in this malignancy. | 25924238 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression. | 25924769 |
| polyps, Primary malignant neoplasm, Adenoma | Epigenetic Alterations | The expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples. | 25924769 |
| Colonic Diseases, Primary malignant neoplasm | Epigenetic Alterations | We identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups. | 25924769 |
| Malignant Neoplasms | Epigenetic Alterations | Changes in the expression of microRNAs (miRNAs) have been found in many cancers. | 25925090 |
| Osteosarcoma, Malignant Bone Neoplasm | Epigenetic Alterations | MicroRNA-145 expression in the plasma of patients with benign and malignant bone tumors and its effects on osteosarcoma cell proliferation and migration. | 25926306 |
| Malignant Bone Neoplasm | Epigenetic Alterations | The difference in microRNA-145 expression level in the tissue between patients with benign and malignant bone tumors were compared and analyzed. | 25926306 |
| Osteosarcoma | Epigenetic Alterations | Human osteosarcoma cell line OS-732 was used for high and low expressions of microRNA-145. | 25926306 |
| Bone neoplasms, Malignant Bone Neoplasm | Epigenetic Alterations | MicroRNA-145 expression level in the plasma of patients with malignant bone tumors was significantly lower than that of patients with benign bone tumors; microRNA-145 expression level in the plasma of patients with benign bone tumors was significantly lower than that of healthy subjects; the differences were statistically significant (P<0.05). | 25926306 |
| Bone neoplasms, Malignant Bone Neoplasm | Epigenetic Alterations | MicroRNA-145 expression level in the tissue of patients with malignant bone tumors was significantly lower than that of patients with benign bone tumors; the difference was statistically significant (P<0.05). | 25926306 |
| Osteosarcoma | Epigenetic Alterations | Cell proliferation level of human osteosarcoma cell line OS-732 interfered with microRNA-145 was significantly increased, and its cell invasion capacity was also significantly increased; the differences were statistically significant (P < 0.05). | 25926306 |
| Osteosarcoma, Malignant Bone Neoplasm, Neoplasms | Epigenetic Alterations | Low expression of microRNA-145 in patients with malignant bone tumors may be involved in cell proliferation and invasion of malignant bone tumors like osteosarcoma as a tumor suppressor. | 25926306 |
| melanoma, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | BRAF activated non-coding RNA (BANCR), a long non-coding RNA (lncRNA), is crucial for cell migration in melanoma cells and non-small cell lung cancer (NSCLC) cells. | 25928067 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Downregulated Long Noncoding RNA BANCR Promotes the Proliferation of Colorectal Cancer Cells via Downregualtion of p21 Expression. | 25928067 |
| Esophageal carcinoma | Epigenetic Alterations | MicroRNA expression levels were further analyzed in regards to clinico-pathological features of esophageal cancer patients. | 25928282 |
| Malignant Neoplasms, Esophageal carcinoma | Epigenetic Alterations | Altered expression of microRNAs has been reported in wide range of malignancies, including esophageal cancer. | 25928282 |
| Esophageal carcinoma | Epigenetic Alterations | Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer. | 25928282 |
| ovarian neoplasm | Epigenetic Alterations | Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer. | 25931269 |
| ovarian neoplasm | Epigenetic Alterations | Our data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis. | 25931269 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | To identify potential molecular prognostic markers in core binding factor (CBF) AML, we analyzed incidences and prognostic impacts of mutations in c-KIT, WT1, CEBPA, CBL, and a number of epigenetic genes in CBF AML. | 25932436 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The incidences of mutations in epigenetic genes are very low in CBF AML; however, c-KIT and WT1 mutations occur more frequently than others. | 25932436 |
| Meningioma, Neoplasms | Epigenetic Alterations | These findings provide insights into RIZ1 tumor suppression mechanisms and suggest that TAT-RIZ1-PR protein is a potential new epigenetic therapeutic agent for advanced meningiomas. | 25934289 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) are short non-coding RNA molecules that play a critical role in mRNA cleavage and translational repression, and are known to be altered in many diseases including breast cancer. | 25934412 |
| Breast Carcinoma, MIR10A gene | Epigenetic Alterations | MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid. | 25934412 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-10a (miR-10a) has been shown to be deregulated in various cancer types. | 25934412 |
| Cerebral Ischemia | Epigenetic Alterations | MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation. | 25934573 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Together, these results suggested for the first time, to the best of our knowledge, ADAMTS1 as a novel antitumor protease, and this function was lost following epigenetic silencing in the gastric cancer cells and gastric tumor tissues. | 25936341 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-383 expression regulates proliferation, migration, invasion, and apoptosis in human glioma cells. | 25936342 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression. | 25936394 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Transcriptional changes were mapped on the myocyte GEM, revealing extensive transcriptional regulation in T2D, particularly around pyruvate oxidation, branched-chain amino acid catabolism, and tetrahydrofolate metabolism, connected through the downregulated dihydrolipoamide dehydrogenase. | 25937284 |
| Prostate Cancer Pathway, Hemorrhage | Epigenetic Alterations | Relation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy for prostate cancer. | 25937401 |
| Degenerative polyarthritis | Epigenetic Alterations | Gain of 5hmC in the gene body is found to be characteristic of activated genes in OA chondrocytes, highlighting the influence of 5hmC as an epigenetic mark in OA. | 25940674 |
| Neoplasms | Epigenetic Alterations | The UHRF1 protein is pivotal for DNA methylation and heterochromatin formation, leading to decreased expressions of tumor suppressor genes and contributing to tumorigenesis. | 25940709 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis. | 25940709 |
| Clinical Coordinator | Epigenetic Alterations | Here we showed that, compared with corresponding normal tissues, UHRF1 was upregulated and microRNA-9 (miR-9) was downregulated in CRC tissues. | 25940709 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | In conclusion, SI-NET tissue microRNAs are always detectable in untreated and SSA-treated patient serum samples, SSAs play an unknown role in eliciting SSA-treated patients microRNA levels higher than in untreated patients, and this study enlightens that miR-200a might be involved in the liver metastasis during SI-NET progression. | 25942502 |
| Small Intestinal Neuroendocrine Tumor | Epigenetic Alterations | Somatostatin Analogs Treated Small Intestinal Neuroendocrine Tumor Patients Circulating MicroRNAs. | 25942502 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Application of artificial neural networks to link genetic and environmental factors to DNA methylation in colorectal cancer. | 25942531 |
| Clinical Coordinator | Epigenetic Alterations | ANNs revealed the complexity of the interconnections among factors linked to DNA methylation in CRC. | 25942531 |
| Hollings Cancer Center | Epigenetic Alterations | Mutations associated with HCC risk were mainly located in HBx transactivation domain, viral promoter, protein/miRNA binding sites, and the area for immune epitopes. | 25942596 |
| Barrett Esophagus, Primary malignant neoplasm | Epigenetic Alterations | Four hundred eight miRNA ratios were differentially expressed in individuals with cancer compared to controls and Barretts esophagus (Mann-Whitney U test, P < 0.05). | 25943911 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma. | 25943911 |
| Primary Neoplasm, Colorectal Cancer Pathway | Epigenetic Alterations | Comparison of genetic and epigenetic alterations of primary tumors and matched plasma samples in patients with colorectal cancer. | 25946211 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | We analyzed the status of the two best characterized colorectal cancer (CRC) genetic and epigenetic alterations in a cohort of CRC patients, and then compared the degree to which the two patterns move from tissue to plasma in order to improve our understanding of biology modulating the concordance between tissues and plasma methylation and mutation profiles. | 25946211 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Circulating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma. | 25950115 |
| Breast Cancer Cell | Epigenetic Alterations | Circulating microRNAs (miRNAs) are emerging as promising non-invasive biomarkers for human cancer. | 25950115 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Genetic and epigenetic status, including mutations of isocitrate dehydrogenase (IDH) and TP53 and methylation of O(6) -methylguanine-DNA methyltransferase (MGMT), are associated with the development of various types of glioma and are useful for prognostication. | 25950388 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | microRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy. | 25950983 |
| Neoplasms | Epigenetic Alterations | Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of microRNA-21 might represent an escape mechanism of tumor cells. | 25950983 |
| Uveal melanoma, Vitreous humor | Epigenetic Alterations | miRNA profiling in vitreous humor, vitreal exosomes and serum from uveal melanoma patients: Pathological and diagnostic implications. | 25951497 |
| Malignant Neoplasms, Vitreous humor | Epigenetic Alterations | Based on the assumption that the profile of circulating miRNAs is often altered in human cancers, we verified whether UM patients showed different vitreous humor (VH) or serum miRNA profiles with respect to healthy controls. | 25951497 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA let-7, a putative tumor suppressor, is dysregulated in many cancers. | 25951903 |
| Malignant Neoplasms | Epigenetic Alterations | Earlier studies demonstrated that microRNAs (miRNAs) might be involved in the chemosensitivity of cancers. | 25951903 |
| Multiple Chronic Conditions, Obesity, Diabetes Mellitus, Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNA 130b has been closely associated with multiple diseases in humans such as cancer, obesity and diabetes mellitus. | 25952368 |
| Glioma | Epigenetic Alterations | However, both the expression pattern of miRNAs in gliomas of different grades and various miRNAs involved in malignant progression of gliomas are poorly understood. | 25954994 |
| Glioma | Epigenetic Alterations | In total, we found 13 differentially expressed miRNAs between gliomas and their matched surrounding tissues. | 25954994 |
| Glioma | Epigenetic Alterations | Our microarray result revealed 8, 9 and 15 aberrantly expressed miRNAs in gliomas of World Health Organization (WHO) grade II-IV, respectively. | 25954994 |
| Malignant neoplasm of endometrium, Primary malignant neoplasm | Epigenetic Alterations | The tumor-suppressive microRNA-1/133a cluster targets PDE7A and inhibits cancer cell migration and invasion in endometrial cancer. | 25955017 |
| Malignant Neoplasms | Epigenetic Alterations | Our recent studies of microRNA (miRNA) expression signatures revealed that the microRNA-1/133a (miR-1/133a) cluster is frequently downregulated in various types of human cancers. | 25955017 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Moreover, restoration of mature miR-1 or miR-133a miRNAs significantly inhibited cancer cell migration and invasion, suggesting that these clustered miRNAs act as tumor suppressors. | 25955017 |
| Metastasis | Epigenetic Alterations | Elucidation of the molecular networks regulated by tumor-suppressive miRNAs will provide insights into the molecular mechanisms of EC oncogenesis and metastasis. | 25955017 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | The role of Epstein-Barr virus-encoded microRNA BART7 status of resection margins in the prediction of local recurrence after salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma. | 25955785 |
| Neoplasms | Epigenetic Alterations | In patients with clear histologic margins, those with margins that were positive for EBV microRNA BART7 has a significantly higher chance of developing local tumor recurrence (P = .016) than those with negative molecular margins. | 25955785 |
| Neoplasms | Epigenetic Alterations | Tissue EBV microRNA BART7 is useful for identifying a subgroup of patients with histologically clear margins who are at increased risk of subsequent local tumor recurrence. | 25955785 |
| Squamous cell carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B. | 25955794 |
| SERPINB3 wt Allele, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | miR-216a has been identified as being involved in tumorigenesis, however, the mechanisms of miR-216a in various types of cancer, either as a tumor suppressor or as an oncogenic miRNA, and the specific regulatory role of miR-216a in OSCC remain to be elucidated. | 25955794 |
| Squamous cell carcinoma, SERPINB3 wt Allele | Epigenetic Alterations | There is increasing evidence to suggest that microRNAs (miRNAs; miRs) are involved in the development of oral squamous cell carcinoma (OSCC). | 25955794 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma. | 25956054 |
| Stomach Carcinoma | Epigenetic Alterations | Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance. | 25956062 |
| Dysplasia | Epigenetic Alterations | Among SF3B1-mutated patients, coexisting mutations in DNA methylation genes were associated with multilineage dysplasia (P = .015) but had no effect on clinical outcome. | 25957392 |
| Stomach Carcinoma | Epigenetic Alterations | Our findings help to indicate the hypermethylation at EGFR promoter in gastric cancer and it could be a potential epigenetic biomarker for gastric cancer status and progression. | 25959250 |
| Malignant Neoplasms | Epigenetic Alterations | Long non-coding RNAs (lncRNAs), which have evolved as important gene expression modulators, are involved in human malignancies. | 25959498 |
| Antilymphocyte Serum | Epigenetic Alterations | The results suggest that more work is needed to elucidate possible environmental, epigenetic, oligogenic and somatic genetic factors that could underlie susceptibility to sporadic ALS. | 25960086 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | microRNAs (miRNAs) are known to be involved in the pathogenesis of hepatocellular carcinoma (HCC). | 25962360 |
| Ovarian Serous Adenocarcinoma | Epigenetic Alterations | Urinary microRNA-30a-5p is a potential biomarker for ovarian serous adenocarcinoma. | 25962395 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) can serve as biomarkers in human cancer. | 25962395 |
| Malignant Neoplasms | Epigenetic Alterations | However, the DNA methylation state of the 45 S rDNA promoter, as well as its effect on rRNA gene expression in types of human cancers is controversial. | 25962577 |
| Myasthenia Gravis | Epigenetic Alterations | Decreased microRNA miR-181c expression in peripheral blood mononuclear cells correlates with elevated serum levels of IL-7 and IL-17 in patients with myasthenia gravis. | 25962782 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Circulating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC). | 25962820 |
| MIR206 wt Allele | Epigenetic Alterations | The miRNAs exhibiting differential expression were hsa-miR-122-5p, has-miR-199a-5p, hsa-miR-486-5p, has-miR-193b-5p, hsa-miR-206, has-miR-141-3p, has-miR-192-5p and has-miR-26a-5p. | 25962820 |
| daunorubicinol | Epigenetic Alterations | These results suggest that DNA methylation impacts AKR7A2 expression and the synthesis of cardiotoxic daunorubicinol. | 25962911 |
| ovarian neoplasm | Epigenetic Alterations | Differential MicroRNA Expression Profiles in Primary and Recurrent Epithelial Ovarian Cancer. | 25964536 |
| ovarian neoplasm | Epigenetic Alterations | Although it has been shown that microRNAs influence messenger RNA post-transcriptional control and can attribute to human tumorigenesis, little is known regarading the differences in microRNA expression between primary and recurrent epithelial ovarian cancer (EOC). | 25964536 |
| Neoplasms | Epigenetic Alterations | Between September 2013 and May 2014, the expression of microRNAs in tumor tissues from 5 primary and 5 recurrent EOC cases were analyzed. | 25964536 |
| Mutation-Negative Lynch Syndrome | Epigenetic Alterations | Among mutation-negative specimens, miRNA testing correctly identified 64% of malignant cases and 98% of benign cases. | 25965083 |
| Neoplasms | Epigenetic Alterations | Interestingly, microRNA-424 was downregulated in clinically normal tongue tissue next to tumour compared with completely healthy tongue, indicating that microRNA-424 could be a marker of field cancerisation in this tumour type. | 25965165 |
| Squamous cell carcinoma | Epigenetic Alterations | Our patient data show that microRNA-424 alterations are a marker of field cancerisation specific for tongue tumourigenesis, which also could have a role in development of tongue squamous cell carcinoma. | 25965165 |
| Squamous cell carcinoma | Epigenetic Alterations | Downregulation of miRNA-424: a sign of field cancerisation in clinically normal tongue adjacent to squamous cell carcinoma. | 25965165 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | MicroRNAs have been suggested as potential prognostic and diagnostic candidates in squamous cell carcinoma of head and neck in general. | 25965165 |
| Carcinoma of lung | Epigenetic Alterations | Our 24-microRNA predictor improves lung cancer prediction beyond that of known risk factors. | 25965386 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating MicroRNAs as Non-Invasive Biomarkers for Early Detection of Non-Small-Cell Lung Cancer. | 25965386 |
| Carcinoma of lung | Epigenetic Alterations | Our objective was to identify a panel of circulating microRNAs in plasma that will contribute to early detection of lung cancer. | 25965386 |
| Malignant Neoplasms, Pancreatic carcinoma | Epigenetic Alterations | Recent researches demonstrate that microRNAs (miRNAs) are deregulated in numerous cancers and involved in tumorigenesis, whereas their influences on pancreatic cancer (PC) still need further elucidation. | 25965392 |
| Carcinoma of lung | Epigenetic Alterations | As one of the most important and widely studied families of microRNA, let-7 appears to play an important role in initiation and progression of lung cancer. | 25966223 |
| Liver carcinoma | Epigenetic Alterations | Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of KLF2. | 25966845 |
| Malignant Neoplasms, Hollings Cancer Center | Epigenetic Alterations | Growing evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in many cancers, including HCC. | 25966845 |
| HIV Infections | Epigenetic Alterations | Overall, our results demonstrate that the epigenetic clock is a useful biomarker for detecting accelerated aging effects due to HIV infection. | 25969563 |
| Conventional (Clear Cell) Renal Cell Carcinoma, Neoplasms | Epigenetic Alterations | Frequent epigenetic suppression of tumor suppressor gene glutathione peroxidase 3 by promoter hypermethylation and its clinical implication in clear cell renal cell carcinoma. | 25970749 |
| Conventional (Clear Cell) Renal Cell Carcinoma, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The goal of this study is to identify novel tumor suppressor genes silenced by promoter methylation in clear cell renal cell carcinoma (ccRCC) and discover new epigenetic biomarkers for early cancer detection. | 25970749 |
| Metastasis | Epigenetic Alterations | Global miRNA profiling on the Training Set and functional analysis in vitro suggested that miRNA-138 and its downstream RHO-ROCK cell adhesion pathway was a convergent target of miRNAs associated with the development of metastasis. | 25970788 |
| Sarcoma | Epigenetic Alterations | Prognostic microRNAs modulate the RHO adhesion pathway: A potential therapeutic target in undifferentiated pleomorphic sarcomas. | 25970788 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | p53-dependent non-coding RNA networks in chronic lymphocytic leukemia. | 25971364 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Whereas p53 targets are used to identify patient subgroups with impaired p53 function, a comprehensive assessment of non-coding RNA targets of p53 in CLL is missing. | 25971364 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | We describe the landscape of p53-dependent microRNA/non-coding RNA induced in response to DNA damage in CLL. | 25971364 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | In addition to miRNAs, the long non-coding RNAs (lncRNAs) nuclear enriched abundant transcript 1 (NEAT1) and long intergenic non-coding RNA p21 (lincRNA-p21) are induced in response to DNA damage in the presence of functional p53 but not in CLL with p53 mutation. | 25971364 |
| Multiple Myeloma | Epigenetic Alterations | miRNA-202 in bone marrow stromal cells affects the growth and adhesion of multiple myeloma cells by regulating B cell-activating factor. | 25971527 |
| Admitting diagnosis | Epigenetic Alterations | Epigenetic dysregulation, including aberrations in histone acetylation, is also associated with AD. | 25972179 |
| Acute Lung Injury | Epigenetic Alterations | Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1. | 25972997 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-141 inhibits migration of gastric cancer by targeting zinc finger E-box-binding homeobox 2. | 25975736 |
| Stomach Carcinoma | Epigenetic Alterations | Human microRNA (miR)-141 is a member of the miR-200 family, which has been reported to be downregulated in gastric cancer, and involved in the proliferation of gastric cancer cells. | 25975736 |
| diabetic, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | miRNA 9 levels were expected to be over expressed in diabetic patients, while miRNA 370 levels were expected to be over expressed in those suffering from CAD and their association with CAD complication of T2D. | 25978320 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | MicroRNAs 9 and 370 Association with Biochemical Markers in T2D and CAD Complication of T2D. | 25978320 |
| Neoplasms | Epigenetic Alterations | Quantifying levels of DNA methylation in tumors is a useful approach for the identification of potential tumor suppressors and to find biomarkers that can be used as prognostic or therapeutic indicators. | 25979762 |
| Malignant Neoplasms, Stomach Carcinoma | Epigenetic Alterations | In the current study, we compared three methods commonly used for quantifying DNA methylation-bisulfite pyrosequencing, quantitative methylation-specific PCR (Q-MSP), and MethyLight-by focusing on the CpG island of the gene encoding the microRNA-34b and microRNA-34c (miR-34b/c); aberrant regulation of this miR is associated with various human malignancies, including gastric cancer. | 25979762 |
| Chromophobe Renal Cell Carcinoma | Epigenetic Alterations | MicroRNA expression profiles predict clinical phenotypes and prognosis in chromophobe renal cell carcinoma. | 25981392 |
| Neoplasms | Epigenetic Alterations | Overall, a total of 105 miRNAs were found to be differentially expressed between tumor and the adjacent normal tissues from 22 chRCC patients. | 25981392 |
| Oropharyngeal Carcinoma, Neoplasms | Epigenetic Alterations | A functional variant at miRNA-122 binding site in IL-1a 3 UTR predicts risk and HPV-positive tumours of oropharyngeal cancer. | 25981582 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Primary malignant neoplasm | Epigenetic Alterations | Oxidative stress and abnormal DNA methylation have been implicated in some types of cancer, namely in myelodysplastic syndromes (MDS). | 25982567 |
| Liver carcinoma | Epigenetic Alterations | A systematic investigation based on microRNA-mediated gene regulatory network reveals that dysregulation of microRNA-19a/Cyclin D1 axis confers an oncogenic potential and a worse prognosis in human hepatocellular carcinoma. | 25985117 |
| Hollings Cancer Center | Epigenetic Alterations | Luciferase reporter assay confirmed that miRNA-19a, which was one of HCC downregulated miRNAs, directly targeted Cyclin D1 in HCC cells. | 25985117 |
| Disease | Epigenetic Alterations | MicroRNAs (miRNAs) contribute to a wide variety of human diseases by regulating gene expression, leading to imbalances in gene regulatory networks. | 25985117 |
| Hollings Cancer Center | Epigenetic Alterations | As a result, a total of 117 HCC differentially expressed miRNAs were identified, and 728 high confident target genes of these miRNAs were collected. | 25985117 |
| Hollings Cancer Center | Epigenetic Alterations | In conclusion, this systematic investigation provides a framework to identify featured miRNAs and their target genes which are potent effectors in the occurrence and development of HCC. | 25985117 |
| Heart failure, Systolic dysfunction | Epigenetic Alterations | The relationship between circulating microRNAs and left ventricular mass in symptomatic heart failure patients with systolic dysfunction. | 25985726 |
| Heart failure | Epigenetic Alterations | In recent years, many microRNAs (miRNAs) were shown to be dysregulated in specific tissues playing critical roles in the pathogenesis and progression of heart failure (HF). | 25985726 |
| Stomach Carcinoma | Epigenetic Alterations | A Long Non-coding RNA Activated by Transforming Growth Factor-b is an Independent Prognostic Marker of Gastric Cancer. | 25986864 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | IDH1/2 mutations which result in alternation in DNA methylation pattern are one of the most common methylation associated mutations in Acute myeloid leukaemia. | 25987093 |
| Colorectal Carcinoma | Epigenetic Alterations | Fecal microRNA profile in patients with colorectal carcinoma before and after curative surgery. | 25989926 |
| Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | Cancer biopsy, colonic mucosa from the resected specimens, and fecal samples from patients and controls were screened for 13 miRNAs involved in CRC onset and progressions by reverse transcription quantitative PCR (RT-qPCR). | 25989926 |
| Primary malignant neoplasm | Epigenetic Alterations | Cancer tissue contained significantly higher expression of all miRNAs, compared to normal mucosa (p < 0.05). | 25989926 |
| Clinical Coordinator | Epigenetic Alterations | Expression of preoperative levels of five fecal miRNAs, (miR-19-b-3p, miR-20a-5p, miR-21-3p, miR92a-3p, miR141) was significantly higher in CRC patients compared to controls and significantly decreased after curative surgery. | 25989926 |
| Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. | 25989926 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA expression profiles in muscle-invasive bladder cancer: identification of a four-microRNA signature associated with patient survival. | 25990459 |
| Iron binding capacity measurement, Aggressive behavior | Epigenetic Alterations | In summary, this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC. | 25990459 |
| MIR20A gene | Epigenetic Alterations | Only 43% (miR-17), 43% (miR-18b), 53% (miR-20a), and 60% (miR-193-3p) showed a continuous in- or decrease of miRNA expression. | 25990502 |
| MIR20A gene, Primary malignant neoplasm | Epigenetic Alterations | Five miRNAs associated with rectal cancer (miR-17, miR-18b, miR-20a, miR-31, and miR-193-3p) were analyzed in the plasma of rectal cancer patients (n = 42) using qPCR. | 25990502 |
| Classical phenylketonuria | Epigenetic Alterations | Altered DNA methylation in PAH deficient phenylketonuria. | 25990862 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | Initial results point to a possible involvement of miRNA in Alzheimers disease (AD). | 25992776 |
| Admitting diagnosis | Epigenetic Alterations | Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. | 25992776 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | The potential role of DNA methylation in abdominal aortic aneurysms. | 25993294 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Adventitial Tertiary Lymphoid Organs as Potential Source of MicroRNA Biomarkers for Abdominal Aortic Aneurysm. | 25993295 |
| atherosclerotic | Epigenetic Alterations | Alternation of histone and DNA methylation in human atherosclerotic carotid plaques. | 25993995 |
| Atherosclerotic lesion | Epigenetic Alterations | We here analysed histone and DNA methylation and the expression of corresponding methyltransferases in early and advanced human atherosclerotic carotid lesions in comparison to healthy carotid arteries. | 25993995 |
| Arteriosclerosis | Epigenetic Alterations | The extent of histone and DNA methylation and expression of some corresponding methyltransferases are significantly altered in atherosclerosis, suggesting a possible contribution of epigenetics in disease development. | 25993995 |
| Arteriosclerosis | Epigenetic Alterations | Little is known about epigenetics and its possible role in atherosclerosis. | 25993995 |
| Lupus Erythematosus | Epigenetic Alterations | Despite growing evidence that large intergenic noncoding RNAs (lincRNAs) can regulate gene expression and widely take part in normal physiological and disease conditions, our knowledge of systemic lupus erythematosus (SLE)-related lincRNAs remains limited. | 25994030 |
| Transitional cell carcinoma of ureter | Epigenetic Alterations | The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells. | 25994132 |
| Hematologic Neoplasms, Primary malignant neoplasm, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Aberrant DNA methylation is known to occur in cancer, including hematological malignancies such as acute myeloid leukemia (AML). | 25996682 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The results showed that decreased methylation at HOXB3 and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML, while increased DNA methylation at DCC distinctive to the high-risk AML was associated with increased gene expression. | 25996682 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-29a inhibits cell migration and invasion via targeting Roundabout homolog 1 in gastric cancer cells. | 25997819 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-377 predicts poor clinical outcome of gastric cancer and induces tumorigenesis by targeting multiple tumor-suppressor genes. | 25998046 |
| Primary malignant neoplasm | Epigenetic Alterations | Specifically, such polymorphisms can modulatebinding affinity or create or destroy miRNA-binding sites; such variants have also been found to be associated with cancer risk. | 25998065 |
| Breast Carcinoma, Breast Cancer Cell | Epigenetic Alterations | MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, including breast cancer. | 25998153 |
| diabetic | Epigenetic Alterations | MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function. | 25999017 |
| Coronary Vessel Bifurcation Lesion | Epigenetic Alterations | We employed miRNA microarray to screen serum miRNAs profiles of patients with coronary bifurcation lesion and coronary nonbifurcation lesions. | 25999658 |
| Cardiovascular Diseases | Epigenetic Alterations | Recent evidence suggests that cell-derived circulating miRNAs may serve as the biomarkers of cardiovascular diseases. | 25999658 |
| Coronary Vessel Bifurcation Lesion | Epigenetic Alterations | Our findings suggest that these miRNAs may have a role in the pathogenesis of coronary bifurcation lesion and may represent novel biomarkers for the diagnosis and prognosis of coronary bifurcation lesion. | 25999658 |
| F9 gene | Epigenetic Alterations | While it is not associated with a more aggressive phenotype of PTC, it correlates with the reduction of all the markers of differentiation and is associated with overexpression of some miRNAs supposed to play a role in thyroid tumorigenesis. | 26003825 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | MicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo. | 26004521 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Accumulating evidence has shown that microRNAs (miRNAs) are aberrantly expressed in human esophageal squamous cell carcinoma (ESCC) and are crucial in tumorigenesis, among which miR-338-3p has been examined to be downregulated in patients with ESCC. | 26004521 |
| Metastasis | Epigenetic Alterations | Emerging evidences indicate that dysregulated microRNAs are implicated in the process of metastasis. | 26007293 |
| Papillary thyroid carcinoma | Epigenetic Alterations | Multivariate analysis involving the expression level of miR-9 and miR-21 and various clinical parameters identified the expression of these microRNAs as independent prognostic factors for papillary thyroid cancer patients. | 26007293 |
| Malignant neoplasm of breast | Epigenetic Alterations | Tissue specific expression of extracellular microRNA in human breast cancers and normal human breast tissue in vivo. | 26008976 |
| Breast Carcinoma | Epigenetic Alterations | After absolute quantifications extracellular miRNA-21 was found to be significantly increased in breast cancer. | 26008976 |
| Carcinogenesis, Premenopause | Epigenetic Alterations | In breast tissue of pre-menopausal women miRNA-21 exhibited a cyclic variation during the menstrual cycle and in postmenopausal women six weeks of tamoxifen treatment decreased miRNA-21 suggesting that this miRNA may be important for breast carcinogenesis. | 26008976 |
| Primary malignant neoplasm | Epigenetic Alterations | Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients. | 26012346 |
| Neoplasms | Epigenetic Alterations | Alterations in DNA methylation patterns have been associated with different types of tumor. | 26012346 |
| Breast Carcinoma, melanoma | Epigenetic Alterations | Since the Uruguayan population is admixed and both melanoma and breast cancer have very high incidences in Uruguay compared to other populations, we examined whether individual ancestry influences global leucocyte DNA methylation status. | 26012346 |
| Primary malignant neoplasm | Epigenetic Alterations | Additionally, we found a negative correlation between African ancestry and global DNA methylation in cancer patients (p <0.005). | 26012346 |
| Primary malignant neoplasm | Epigenetic Alterations | These results support the potential use of global DNA methylation as a biomarker for cancer risk. | 26012346 |
| Breast Carcinoma, melanoma | Epigenetic Alterations | In order to detect markers of susceptibility for the development of cutaneous melanoma and breast cancer in the Uruguayan population, we integrated genetic and epigenetic information of patients and controls. | 26012346 |
| B-Lymphocytes, Diabetes, Autoimmune | Epigenetic Alterations | The small contribution of b-cells to total plasma miR-375 levels make this miRNA an unlikely biomarker for b-cell function but suggests a utility for the detection of acute b-cell death for autoimmune diabetes. | 26013143 |
| Vasculitis, CTCAE | Epigenetic Alterations | Circulating microRNA expression pattern separates patients with anti-neutrophil cytoplasmic antibody associated vasculitis from healthy controls. | 26016752 |
| MIR20A gene | Epigenetic Alterations | Seven individual miRNAs were differently expressed compared to controls in both cohorts; miR-29a, -34a, -142-3p and -383 were up-regulated and miR-20a, -92a and -221 were down-regulated. | 26016752 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-217 functions as a prognosis predictor and inhibits colorectal cancer cell proliferation and invasion via an AEG-1 dependent mechanism. | 26016795 |
| Cardiovascular | Epigenetic Alterations | Smoking-Associated DNA Methylation Biomarkers and Their Predictive Value for All-Cause and Cardiovascular Mortality. | 26017925 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs play critical roles in the development and progression of human cancers. | 26018509 |
| Liver carcinoma | Epigenetic Alterations | DNA methylation markers and serum a-fetoprotein level are prognostic factors in hepatocellular carcinoma. | 26019036 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4. | 26019136 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Expression profile of microRNAs in gastrointestinal stromal tumors revealed by high throughput quantitative RT-PCR microarray. | 26019448 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | We performed a quantitative real-time quantitative reverse transcriptase polymerase chain reaction assay to analyze the expression of 1888 miRNAs in a sample set that included 54 GIST tissue samples. | 26019448 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | We found that dysregulation of several miRNAs may be related to the malignant potential of GISTs. | 26019448 |
| Gastrointestinal Stromal Sarcoma | Epigenetic Alterations | Six of these miRNAs, hsa-let-7c, miR-218, miR-488#, miR-4683, miR-34c-5p and miR-4773, were selected as the final list of biomarkers to separate the malignant GISTs (M group) from the benign GISTs (B group). | 26019448 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | The identified miRNAs appear to be novel biomarkers to distinguish malignant from benign GISTs, which may be helpful to understand the mechanisms of GIST oncogenesis and progression, and to further elucidate the characteristics of GIST subtypes. | 26019448 |
| Prostate Cancer Pathway | Epigenetic Alterations | MiRNA Profiles in Lymphoblastoid Cell Lines of Finnish Prostate Cancer Families. | 26020509 |
| Prostate Cancer Pathway | Epigenetic Alterations | Annotating the SNPs with deep clinical data together with miRNA expression profiles can improve the understanding of the underlying mechanisms of different phenotypes of prostate cancer. | 26020509 |
| Pancreatic carcinoma | Epigenetic Alterations | New DNA Methylation Markers for Pancreatic Cancer: Discovery, Tissue Validation, and Pilot Testing in Pancreatic Juice. | 26023084 |
| Pancreatic carcinoma | Epigenetic Alterations | We identified and validated novel DNA methylation markers strongly associated with pancreatic cancer. | 26023084 |
| SF3B1 wt Allele | Epigenetic Alterations | Furthermore, at miRNA expression profile, MDS ECFCs hypo-expressed various miRNAs involved in Wnt pathway regulation. | 26025663 |
| Primary malignant neoplasm | Epigenetic Alterations | There is increasing evidence that the expression of microRNA (miRNA) in cancer is associated with chemosensitivity but the mechanism of miRNA-induced chemoresistance has not been fully elucidated. | 26026166 |
| Osteoporotic Fractures | Epigenetic Alterations | Overall, these data suggest that levels of specific circulating miRNAs change in the context of recent osteoporotic fractures and that such perturbations of "normal" levels might affect bone metabolism or bone healing processes. | 26026730 |
| Neoplasms | Epigenetic Alterations | Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. | 26026961 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Epigenetic changes, including DNA methylation, are recognized as one of the potential mechanisms involved in the pathogenesis of hepatocellular carcinoma (HCC). | 26030814 |
| Hepatocarcinogenesis, Hepatitis C | Epigenetic Alterations | Aberrant methylation of promoter region of SPINT2/HAI-2 gene: an epigenetic mechanism in hepatitis C virus-induced hepatocarcinogenesis. | 26030814 |
| cervical cancer | Epigenetic Alterations | MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT. | 26034994 |
| Neoplasms | Epigenetic Alterations | MicroRNA-491-5p (miR-491-5p), an important miRNA, has been demonstrated to be involved in the processes of initiation and progression in several tumors. | 26034994 |
| Clinical Coordinator | Epigenetic Alterations | We conducted a systematic discovery and validation of microRNA (miRNA) biomarkers in two clinical trial cohorts of CRC patients. | 26035698 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | We performed an initial discovery phase using Affymetrix miRNA expression arrays to profile stage III CRC patients with and without tumour recurrence (n=50 per group) at 3-years of follow-up. | 26035698 |
| Clinical Coordinator | Epigenetic Alterations | During validation, we analysed miRNAs using qRT-PCR in an independent cohort of 237 stage II-IV CRC patients treated with 5-FU-based chemotherapy, as well as in normal colonic mucosa from 20 healthy subjects. | 26035698 |
| Colorectal Cancer Pathway, Colorectal Neoplasms | Epigenetic Alterations | Circulating microRNAs (miRNA) are emerging as promising diagnostic biomarkers for colorectal cancer, but their usefulness for detecting early colorectal neoplasms remains unclear. | 26038573 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. | 26039340 |
| Carcinogenesis | Epigenetic Alterations | We set out to identify DNA methylation patterns associated with arsenic and its metabolites in exfoliated urothelial cells (EUCs) that originate primarily from the urinary bladder, one of the targets of arsenic-induced carcinogenesis. | 26039340 |
| Pancreatic carcinoma | Epigenetic Alterations | Pancreatic cancer patient survival correlates with DNA methylation of pancreas development genes. | 26039411 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Our results suggest that THM exposure may affect DNA methylation in genes related to tumors, including colorectal and bladder cancers. | 26039576 |
| Cerebrovascular accident | Epigenetic Alterations | Differential Regulation of microRNAs in Patients with Ischemic Stroke. | 26044809 |
| Cerebrovascular Disorders | Epigenetic Alterations | MicroRNAs play an important role in atherosclerosis-related diseases, such as cerebrovascular and cardiovascular disease. | 26044809 |
| Malignant Neoplasms, Stomach Carcinoma, doxorubicin/mercaptopurine/prednisone/vincristine protocol | Epigenetic Alterations | To elucidate the mechanism of radiation-induced cancers, we analyzed the expression profiles of microRNAs extracted from formalin-fixed paraffin-embedded (FFPE) gastric cancer (GC) tissue samples from atomic bomb survivors. | 26045155 |
| Stomach Carcinoma | Epigenetic Alterations | Identification of differentially expressed signatures of long non-coding RNAs associated with different metastatic potentials in gastric cancer. | 26045391 |
| Metastasis | Epigenetic Alterations | Several long, non-coding RNAs (lncRNAs) play important roles in gastric tumorigenesis and metastasis. | 26045391 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | microRNA (mir)-365 exerts tumor suppressor function by targeting thyroid transcription factor-1 (TTF-1) in lung cancer cells. | 26045746 |
| Liver carcinoma | Epigenetic Alterations | High expression of long non-coding RNA ANRIL is associated with poor prognosis in hepatocellular carcinoma. | 26045820 |
| Primary malignant neoplasm | Epigenetic Alterations | long non-coding RNA ANRIL (lncRNA ANRIL) has been demonstrated to play a crucial role in cancer progression. | 26045820 |
| melanoma | Epigenetic Alterations | Decreased serum microRNA-206 level predicts unfavorable prognosis in patients with melanoma. | 26045823 |
| melanoma, Neoplasms | Epigenetic Alterations | MicroRNA-206 (miR-206) acts as a tumor suppressor in melanoma cell lines. | 26045823 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression and function in tumor development and progression. | 26046464 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | We previously identified up-regulated miRNAs in clear cell renal cell carcinoma (ccRCC) compared to matched-pair normal kidney by microarray. | 26046464 |
| Liver carcinoma | Epigenetic Alterations | A Seven-microRNA Expression Signature Predicts Survival in Hepatocellular Carcinoma. | 26046780 |
| Hollings Cancer Center | Epigenetic Alterations | However, limited information is available regarding genome-wide miRNA expression profiles in HCC to generate a tumor-specific miRNA signature of prognostic values. | 26046780 |
| Malignant Neoplasms | Epigenetic Alterations | The differential expression of microRNAs (miRNAs) has been associated with the prognosis of various cancers. | 26046780 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | miRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers. | 26048406 |
| Disease | Epigenetic Alterations | Long noncoding RNA (lncRNA) plays a crucial role in the regulation of various cellular processes and human diseases. | 26050227 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway | Epigenetic Alterations | Aberrant expression of long noncoding RNAs in colorectal cancer with liver metastasis. | 26050227 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Identification and characterization of the gene expression profiles for protein coding and non-coding RNAs of pancreatic ductal adenocarcinomas. | 26053098 |
| Stomach Carcinoma | Epigenetic Alterations | However little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in gastric cancer. | 26054683 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | Long non-coding RNAs (lncRNAs), emerging non-coding RNAs, have been proved to serve as a critical role in the proliferation, metastasis apoptosis of gastric cancer. | 26054683 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer. | 26056045 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | Our results revealed for the first time that TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is an independent prognostic factor of lung cancer. | 26056045 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumour suppressors contributes to the development and progression of lung cancer. | 26056045 |
| Embryonal Rhabdomyosarcoma | Epigenetic Alterations | Twenty transcripts (10 annotated, 10 noncoding RNAs) were significantly differentially expressed in ERMS when compared with PPB samples. | 26056800 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Circulating microRNAs as prognostic therapy biomarkers in head and neck cancer patients. | 26057452 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | All miRNAs identified as biomarker candidates were then confirmed in an independent validation cohort of HNSCC patients and tested for correlation with the clinical outcome. | 26057452 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | We identified a signature of eight plasma miRNAs that differentiated significantly (P=0.003) between HNSCC patients and healthy donors. | 26057452 |
| Neoplasms | Epigenetic Alterations | All therapy-responsive and patient-specific miRNAs in plasma were also detectable in tumour tissues derived from the same patients. | 26057452 |
| Squamous cell carcinoma of the head and neck, Neoplasms | Epigenetic Alterations | We found strong evidence that the circulating therapy-responsive miRNAs are tumour related and were able to validate them in an independent cohort of HNSCC patients. | 26057452 |
| Primary malignant neoplasm | Epigenetic Alterations | By implementing a triple-filtering approach we identified a subset of highly biologically relevant miRNA-mRNA interactions and we demonstrated that the same genes/pathways affected by somatic mutations in cancer are affected by changes in the abundance of miRNAs. | 26057471 |
| Primary malignant neoplasm | Epigenetic Alterations | Therefore, one important conclusion from our work is that during cancer development, there seems to be a convergence of oncogenic processes driven by somatic mutations and/or miRNA regulation affecting key cellular pathways. | 26057471 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | We identified, for the first time, a multi-marker signature of 3 major classes of circulating sncRNAs in HNSCC, revealing the presence of circulating novel and known miRNAs, and tRNA- and YRNA-derived small RNAs that were significantly deregulated in the sera of HNSCC patients compared to healthy controls. | 26057471 |
| Squamous cell carcinoma | Epigenetic Alterations | Long non-coding RNA HOTTIP is correlated with progression and prognosis in tongue squamous cell carcinoma. | 26058875 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been demonstrated to be a critical role in cancer progression and prognosis. | 26058875 |
| Prostate Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer. | 26059417 |
| Primary malignant neoplasm | Epigenetic Alterations | Restoration of microRNA-205 in cancer cell lines significantly inhibited cancer cell migration and invasion. | 26059417 |
| Prostate Cancer Pathway | Epigenetic Alterations | Our data showed that the centromere protein F gene was overexpressed in prostate cancer clinical specimens and was a direct target of microRNA-205 regulation. | 26059417 |
| Prostate Cancer Pathway, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Loss of tumor-suppressive microRNA-205 seems to enhance cancer cell migration and invasion in prostate cancer through direct regulation of centromere protein F. Our data describing pathways regulated by tumor-suppressive microRNA-205 provide new insights into the potential mechanisms of prostate cancer oncogenesis and metastasis. | 26059417 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Unsupervised clustering of mutations and data from RNA, DNA-copy-number, and DNA-methylation platforms uncovered concordant classification of three robust, nonoverlapping, prognostically significant subtypes of lower-grade glioma that were captured more accurately by IDH, 1p/19q, and TP53 status than by histologic class. | 26061751 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer. | 26062455 |
| Breast Carcinoma | Epigenetic Alterations | miRNA profiling studies have suggested that miR-196a is highly overexpressed in breast cancer. | 26062455 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | MicroRNA-153 is a prognostic marker and inhibits cell migration and invasion by targeting SNAI1 in human pancreatic ductal adenocarcinoma. | 26062664 |
| Neoplasm Metastasis | Epigenetic Alterations | miR-153 has been suggested as a novel tumor-associated miRNA, which is involved in tumor metastasis. | 26062664 |
| Metastasis, Neoplasms | Epigenetic Alterations | Mounting evidence suggests that microRNAs (miRNAs) act as critical factors for tumor recurrence and metastasis. | 26062664 |
| Triple-Negative Breast Cancer Finding, Neoplasms | Epigenetic Alterations | Tumor tissue microRNA expression in association with triple-negative breast cancer outcomes. | 26062749 |
| Neoplasms | Epigenetic Alterations | Incorporating the miRNA score with known TNBC outcome predictors, i.e., age at diagnosis, tumor stage, and basal-like subtype, increased the C-index for predicting DFS from 0.68 to 0.74. | 26062749 |
| Malignant Neoplasms | Epigenetic Alterations | However, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. | 26063036 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | When these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin. | 26063036 |
| Carcinogenesis, Metastasis | Epigenetic Alterations | Elucidation of the molecular networks regulated by tumor-suppressive miRNAs will provide insights into the molecular mechanisms of PCa oncogenesis and metastasis. | 26063484 |
| Malignant Neoplasms | Epigenetic Alterations | Inactivation of methylcytosine dioxygenase, ten-eleven translocation (TET) is known to be associated with aberrant DNA methylation in cancers. | 26063725 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Tumors with a CpG island methylator phenotype (CIMP), a distinct subgroup with extensive DNA methylation, show characteristic features in the case of colorectal cancer. | 26063725 |
| Colorectal Carcinoma, Colonic Polyps | Epigenetic Alterations | Furthermore, DNA methylation profiling, including assessment of the TET1 gene, was assessed in colorectal cancers, as well as colon polyps. | 26063725 |
| Colorectal Carcinoma | Epigenetic Alterations | The TET1 was silenced by DNA methylation in a subset of colorectal cancers as well as cell lines, expression of which was reactivated by demethylating agent. | 26063725 |
| Stomach Carcinoma | Epigenetic Alterations | Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. | 26063956 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-21 was upexpressed in gastric cancer (GC) indicating that it is a potential diagnostic biomarker for GC. | 26063956 |
| Primary malignant neoplasm, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Patterns of global histone modifications have been recently suggested as outcome predictors in cancer patients, but few studies have been conducted on pancreatic ductal adenocarcinomas (PDACs). | 26067135 |
| Neoplasms, Cessation of life | Epigenetic Alterations | Epigenetic deregulation may be involved in tumor cell biology, including differentiation, tumor progression, and cell death, and histone acetylation is a major regulatory mechanism of gene transcription. | 26067135 |
| Degenerative polyarthritis | Epigenetic Alterations | We report novel findings that DNA methylation regulates SOSTs expression in OA, by changing Smad 1/5/8 binding affinity to SOST promoter, providing evidence that changes in DNA methylation pattern could underlie changes in genes expression observed in OA. | 26071314 |
| Feel Pain | Epigenetic Alterations | Analgesic Response to Intravenous Ketamine Is Linked to a Circulating microRNA Signature in Female Patients With Complex Regional Pain Syndrome. | 26072390 |
| Carcinogens, Neoplasms | Epigenetic Alterations | The best known and more frequent epigenetic alteration is DNA methylation affecting tumor suppressor genes that may be involved in various carcinogenetic pathways. | 26073472 |
| Carcinogenesis | Epigenetic Alterations | Gastric carcinogenesis is a multistep process including not only genetic mutations but also epigenetic alterations. | 26073472 |
| Stomach Carcinoma | Epigenetic Alterations | Serum RASSF1A and APC promoter hypermethylation is a frequent epigenetic event in patients with early operable gastric cancer. | 26073472 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is the most common and well-characterized epigenetic change in human cancer. | 26074659 |
| methionine, Secondary malignant neoplasm of lung | Epigenetic Alterations | Comprehensive gene and microRNA expression profiling reveals miR-206 inhibits MET in lung cancer metastasis. | 26075299 |
| methionine | Epigenetic Alterations | One of its predicted targets in our miRNA-gene network, MET, was also obviously decreased at the protein level when miR-206 was overexpressed. | 26075299 |
| Secondary malignant neoplasm of lung, methionine | Epigenetic Alterations | In conclusion, our study provided a miRNA-gene regulatory network in lung cancer metastasis and further demonstrated the roles of miR-206 and MET in this process, which enhances the understanding of the regulatory mechanism in lung cancer metastasis. | 26075299 |
| Carcinoma of lung, Metastasis | Epigenetic Alterations | MiRNAs associated with the metastasis of lung cancer remain largely unexplored. | 26075299 |
| Carcinoma of lung | Epigenetic Alterations | Using the qRT-PCR method, the six miRNAs were further confirmed to show a significant expression difference between human lung cancer and normal tissue samples. | 26075299 |
| Malignant Neoplasms, DICER1 protein, human | Epigenetic Alterations | Dicer is a key enzyme in miRNA processing pathway, and dysregulation of its expression has been suggested as a possible cause of miRNAome alterations observed in various cancers. | 26076803 |
| Primary malignant neoplasm | Epigenetic Alterations | There is an urgent need of comprehensive longitudinal analyses of circulating miRNA patterns to identify dynamic changes of miRNAs in cancer patients after surgery. | 26078336 |
| Neoplasms | Epigenetic Alterations | This analysis provided further evidence of miRNA plasma levels that are changing over time after tumor resection and correlate to patient outcome. | 26078336 |
| Psychotic Disorders | Epigenetic Alterations | New epigenetic technologies may uncover etiopathogenic mechanisms of major psychosis. | 26078387 |
| Mental disorders | Epigenetic Alterations | Our findings revealed new epigenetic complexities but also highlighted the potential of DNA modification approaches in the search of heterogeneous causes of major psychiatric disease. | 26078387 |
| Prostate Cancer Pathway | Epigenetic Alterations | Stability Assessment of Candidate Reference Genes in Urine Sediment of Prostate Cancer Patients for miRNA Applications. | 26078486 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Downregulation of microRNA-382 is associated with poor outcome of esophageal squamous cell carcinoma. | 26078564 |
| Carcinoma of lung | Epigenetic Alterations | Plasma circulating microRNA-944 and microRNA-3662 as potential histologic type-specific early lung cancer biomarkers. | 26079400 |
| Neoplasms | Epigenetic Alterations | Possibility of detection of miRNA expression in patients plasma or serum makes them valuable biomarkers of different neoplasms. | 26079400 |
| Carcinoma of lung | Epigenetic Alterations | Higher stage of lung cancer correlated with higher miRNA expressions. | 26079400 |
| Malignant Neoplasms | Epigenetic Alterations | Altered expression of microRNAs (miRNAs) is associated with the development and invasion of cancers by regulating post-transcriptionally gene function. | 26079400 |
| TSPYL2 wt Allele, Neoplasms | Epigenetic Alterations | Multiple mutations were identified that affected the same pathways, including epigenetic, cell-fate regulation, and cytokine signaling, in MF tumors and CTCL cell lines. | 26082451 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | One microRNA (miR-34c-5p) was validated as significantly over-expressed in T2D monocytes. | 26083362 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | The expression profile of microRNAs/mRNAs in monocytes of T2D patients indicates an altered adhesion, differentiation, and shape change potential. | 26083362 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Aberrant DNA methylation of various genes has been identified to be associated with disease progression in chronic myeloid leukemia (CML). | 26086097 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Epigenetic inactivation of DLX4 is associated with disease progression in chronic myeloid leukemia. | 26086097 |
| Prostate Cancer Pathway | Epigenetic Alterations | DNA Methylation-Guided Prediction of Clinical Failure in High-Risk Prostate Cancer. | 26086362 |
| CHOANAL ATRESIA, POSTERIOR, Neoplasms | Epigenetic Alterations | Classification of primary high-risk tumors into three subtypes based on DNA methylation can be combined with clinico-pathological parameters for a more informative risk-stratification of these PCa patients. | 26086362 |
| Cardiac Hypertrophy | Epigenetic Alterations | Blood-based microRNA signatures differentiate various forms of cardiac hypertrophy. | 26086795 |
| Acromegaly | Epigenetic Alterations | We also identified several novel transcriptional changes, some of which may be important for GH/IGF responses (PTPN3 and PTPN4) and the effects of acromegaly on growth and proliferation. | 26087292 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation has been reported in many cancers, suggesting that it can be utilized as an early biomarker to improve the early diagnosis rate. | 26090379 |
| Degenerative polyarthritis | Epigenetic Alterations | The Long Noncoding RNA MEG3 Is Downregulated and Inversely Associated with VEGF Levels in Osteoarthritis. | 26090403 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | We used ELISA and immunohistochemistry tests to analyze 5-hmC status in ESCC tissues, RT-qPCR to analyze TET family mRNA expression in normal and tumor tissues, and pyrosequencing to quantify LINE-1 (i.e., global DNA methylation) levels. | 26093090 |
| Injury of pancreas | Epigenetic Alterations | A pancreatic miRNA signature can be useful for assessment of pancreatic injury in the acute phase of AP. | 26094040 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Decreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma. | 26097558 |
| Malignant Neoplasms | Epigenetic Alterations | accumulating evidence suggest that long non-coding RNAs (lncRNAs) may play important roles in human cancers. | 26097558 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Epigenetic and genetic alteration plays a major role to the development of head and neck squamous cell carcinoma (HNSCC). | 26098903 |
| Disease | Epigenetic Alterations | Although DNA methylation is now recognized as an important mediator of complex diseases, the extent to which the genetic basis of such diseases is accounted for by DNA methylation is unknown. | 26101197 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Novel epigenetic determinants of type 2 diabetes in Mexican-American families. | 26101197 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Our study has identified novel epigenetic indicators of T2D risk in Mexican Americans who have increased risk for this disease. | 26101197 |
| Squamous cell carcinoma, Neoplasm Metastasis | Epigenetic Alterations | We corroborate literature data on the role of small RNAs in cancer metastasis and suggest the detection of microRNAs as a tool that may assist in the evaluation of oral squamous cell carcinoma metastatic potential. | 26104160 |
| Colorectal Carcinoma | Epigenetic Alterations | Epigenetics could explain some Moroccan population colorectal cancers peculiarities: microsatellite instability pathway exploration. | 26104511 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | The expression of microRNA-34a is inversely correlated with c-MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients. | 26104764 |
| Malignant tumor of colon, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts. | 26105520 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNAs (miRs) are proposed as colorectal cancer (CRC) biomarkers. | 26105520 |
| Prostate Cancer Pathway | Epigenetic Alterations | Mechanistically, this was associated with epigenetics silencing of the MIR34B/C locus and increased DNA copy number loss, selectively in androgen-dependent prostate cancer. | 26107383 |
| Prostate Cancer Pathway, Adenocarcinoma | Epigenetic Alterations | Here, we used an integrated discovery platform combining prostate cancer cell lines, a Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model and clinically-annotated human tissue samples to identify loss of expression of microRNA-34b as consistently associated with prostate cancer relapse. | 26107383 |
| T-Cell Prolymphocytic Leukemia | Epigenetic Alterations | Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia. | 26109102 |
| malignant disease | Epigenetic Alterations | Aging is associated with highly reproducible DNA methylation (DNAm) changes, which may contribute to higher prevalence of malignant diseases in the elderly. | 26110659 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic Aging Signatures Are Coherently Modified in Cancer. | 26110659 |
| Primary malignant neoplasm | Epigenetic Alterations | In this study, we analyzed epigenetic aging signatures in 5,621 DNAm profiles of 25 cancer types from The Cancer Genome Atlas (TCGA). | 26110659 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | For example, in acute myeloid leukemia (AML) higher epigenetic age-predictions are associated with increased incidence of mutations in RUNX1, WT1, and IDH2, whereas mutations in TET2, TP53, and PML-PARA translocation are more frequent in younger age-predictions. | 26110659 |
| Esophageal carcinoma, Chromophobe Renal Cell Carcinoma, Squamous cell carcinoma of lung, Glioblastoma Multiforme Pathway, Glioblastoma Multiforme, Primary malignant neoplasm, melanoma, Neuroendocrine Tumors | Epigenetic Alterations | Furthermore, epigenetic aging signatures correlate with overall survival in several types of cancer (such as lower grade glioma, glioblastoma multiforme, esophageal carcinoma, chromophobe renal cell carcinoma, cutaneous melanoma, lung squamous cell carcinoma, and neuroendocrine neoplasms). | 26110659 |
| Primary malignant neoplasm | Epigenetic Alterations | Furthermore, the apparent epigenetic age-predictions correlate with clinical parameters and overall survival in several types of cancer, indicating that regulation of DNAm patterns in age-associated CpGs is relevant for cancer development. | 26110659 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Alterations in DNA methylation contribute to the abnormal phenotype of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). | 26111028 |
| Lung Neoplasms | Epigenetic Alterations | High percentage of lung tumor samples with simultaneous RASSF1A decreased expression and gene promoter methylation indicates its epigenetic silencing. | 26112163 |
| Breast Carcinoma | Epigenetic Alterations | We and others have previously reported widespread changes in DNA methylation using breast cancer cell line models of endocrine resistance. | 26113056 |
| Breast Carcinoma | Epigenetic Alterations | In summary, our studies show, for the first time, that overexpression of histone variants might be important in endocrine response in ER+ breast cancer, and that overexpression is at least in part mediated via epigenetic mechanisms and amplifications. | 26113056 |
| Diabetic Retinopathy, diabetic | Epigenetic Alterations | Expression of Angiogenic MicroRNAs in Endothelial Progenitor Cells From Type 1 Diabetic Patients With and Without Diabetic Retinopathy. | 26114486 |
| Pancreatic carcinoma | Epigenetic Alterations | To identify plasma microRNA (miRNA) markers of pancreatic cancer (PC). | 26114496 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic reprogramming that imparts functional changes in gene expression, the development of cancer stem cells, and immunomodulation are plausible underlying mechanisms by which early-life iAs exposure elicits latent carcinogenic effects. | 26115410 |
| Myeloproliferative disease, Myelofibrosis | Epigenetic Alterations | Up-regulation of MicroRNA 146b is Associated with Myelofibrosis in Myeloproliferative Neoplasms. | 26116595 |
| Uterine Cervical Neoplasm, Human papilloma virus infection | Epigenetic Alterations | Different DNA methylation pattern of HPV16, HPV18 and HPV51 genomes in asymptomatic HPV infection as compared to cervical neoplasia. | 26119875 |
| cervical cancer | Epigenetic Alterations | An increased DNA methylation level of HPV16 promoter region in case of cervical cancer was determined. | 26119875 |
| Malignant Neoplasms, Stomach Carcinoma | Epigenetic Alterations | To improve the outcome of patients suffering from gastric cancer, a better understanding of underlying genetic and epigenetic events in this malignancy is required. | 26121593 |
| Pancreatic carcinoma | Epigenetic Alterations | Salivary MicroRNA in Pancreatic Cancer Patients. | 26121640 |
| Primary malignant neoplasm | Epigenetic Alterations | In experimental models of PDAC, salivary microRNA detection precedes systemic detection of cancer cells markers. | 26121640 |
| Primary malignant neoplasm | Epigenetic Alterations | In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. | 26121640 |
| Breast Carcinoma | Epigenetic Alterations | Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population. | 26125831 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. | 26125831 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Epigenetic silencing of the GSTP1 gene by promoter methylation has been associated with increased risk and shortened survival in patients with hepatocellular carcinoma (HCC). | 26125884 |
| Squamous cell carcinoma, Neoplasms | Epigenetic Alterations | Decreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma. | 26125902 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-143 serves as a tumor suppressor in many human malignancies. | 26125902 |
| CHOANAL ATRESIA, POSTERIOR, Hormone refractory prostate cancer | Epigenetic Alterations | Therefore, it was concluded that gene transcription and protein expression of YAP may be involved in the development of PCa, particularly CRPC, and may be a novel biomarker for investigation of the occurrence and progression of CRPC. | 26126522 |
| Acute leukemia | Epigenetic Alterations | MicroRNAs (miRs), small endogenous noncoding RNAs, play an essential role in the development and progression of acute leukemia. | 26126974 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Low expression of microRNA-204 (miR-204) is associated with poor clinical outcome of acute myeloid leukemia (AML) patients. | 26126974 |
| Neoplasms | Epigenetic Alterations | Furthermore, high microRNA-122 expression (hazard ratio [HR]=2.67; 95% confidence interval [CI]=1.12-6.35; P=0.026) and advanced tumor stage (HR=2.27; 95% CI=1.23-4.18; P=0.009) were independent risk factors for poor OS in patients treated with RFA. | 26129878 |
| Neoplasms | Epigenetic Alterations | The combination of microRNA-122 and tumor stage resulted in an area under the curve of 0.818 for predicting 1-year OS in patients who underwent RFA. | 26129878 |
| Adenocarcinoma of lung, stage I | Epigenetic Alterations | An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers. | 26134223 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Genome-wide screening of DNA methylation and pyrosequencing analysis of HOXA9 promoter methylation were performed in two independently collected cohorts of stage I lung adenocarcinoma. | 26134223 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are a type of small non-coding RNA molecule that play important roles in tumor initiation, chemotherapy response, promotion, and progression by negatively interfering with gene expression. | 26134365 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in cervical carcinogenesis and progression. | 26134491 |
| Malignant Neoplasms | Epigenetic Alterations | microRNA-133a (miR-133a) has been reported to play a tumor-suppressor role in a range of cancers. | 26134491 |
| Inflammation, Neoplasms | Epigenetic Alterations | Chronic inflammation as an important epigenetic and environmental factor for putative tumorigenesis and tumor progression may be associated with specific activation of Toll-like receptors (TLR). | 26134824 |
| Psoriasis, Hyperplasia | Epigenetic Alterations | NF-kB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. | 26138368 |
| Psoriatic Juvenile Idiopathic Arthritis | Epigenetic Alterations | Here we report that the NF-kB activation triggered by inflammatory cytokines induces the transcription of microRNA (miRNA) miR-31, one of the most dynamic miRNAs identified in the skin of psoriatic patients and mouse models. | 26138368 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Integrative functional genetic-epigenetic approach for selecting genes as urine biomarkers for bladder cancer diagnosis. | 26138586 |
| Metastasis, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Detection of the long noncoding RNAs nuclear-enriched autosomal transcript 1 (NEAT1) and metastasis associated lung adenocarcinoma transcript 1 in the peripheral blood of HIV-1-infected patients. | 26139386 |
| Malignant neoplasm of breast, Mammary Neoplasms | Epigenetic Alterations | MiR-190b, the highest up-regulated miRNA in ERa-positive compared to ERa-negative breast tumors, a new biomarker in breast cancers? | 26141719 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) show differential expression across breast cancer subtypes and have both oncogenic and tumor-suppressive roles. | 26141719 |
| Malignant neoplasm of breast | Epigenetic Alterations | We used the robust and reproductive tool of quantitative RT-PCR in a large cohort of well-annotated 153 breast cancers with long-term follow-up to identify miRNAs specifically differentially expressed between ER(+) and ER(-) breast cancers. | 26141719 |
| Malignant neoplasm of breast | Epigenetic Alterations | We identified a robust collection of 20 miRNAs significantly deregulated in ER(+) compared to ER(-) breast cancers : 12 up-regulated and eight down-regulated miRNAs. | 26141719 |
| Carcinoma of lung | Epigenetic Alterations | Differential miRNA expressions in peripheral blood mononuclear cells for diagnosis of lung cancer. | 26146958 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Tremendous efforts have been made to develop cancer biomarkers by detecting circulating extracellular miRNAs directly released from tumors. | 26146958 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We first used a microarray to analyze PBMCs of 16 stage I NSCLC patients and 16 cancer-free smokers, and identified seven PBMC miRNAs with a significantly altered expression level in NSCLC patients. | 26146958 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In a training set of 84 NSCLC patients and 69 cancer-free smokers, a panel of two miRNAs (miRs-19b-3p and -29b-3p) were developed from the seven PBMC miRNAs, producing 72.62% sensitivity and 82.61% specificity in identifying NSCLC. | 26146958 |
| Squamous cell carcinoma of lung, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Furthermore, the miRNAs could identify squamous cell lung carcinoma (SCC), a major type of NSCLC, with 80.00% sensitivity and 89.86% specificity. | 26146958 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The assessment of PBMC miRNAs may provide a new diagnostic approach for the early detection of NSCLC. | 26146958 |
| GTP-Binding Nuclear Protein Ran, Human, Colorectal Cancer Pathway | Epigenetic Alterations | 3-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population. | 26147304 |
| Initiation | Epigenetic Alterations | MicroRNAs play an important role in cancer initiation and development. | 26147304 |
| Manic | Epigenetic Alterations | We conclude that mania is associated with alterations in levels of DNA methylation and inflammatory markers. | 26147665 |
| Mood Disorders | Epigenetic Alterations | Since epigenetic markers are potentially malleable, a better understanding of the role of epigenetics may lead to new methods for the prevention and treatment of mood disorders. | 26147665 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic changes play significant roles in cancer development. | 26147747 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | UHRF1, an epigenetic regulator, has been shown to be overexpressed and to coordinate tumor suppressor gene (TSG) silencing in several cancers. | 26147747 |
| melanoma, Cessation of life | Epigenetic Alterations | Expression and clinicopathological significance of microRNA-21 and programmed cell death 4 in malignant melanoma. | 26150475 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA 211 expression is upregulated and associated with poor prognosis in colorectal cancer: a case-control study. | 26152286 |
| Breast Carcinoma | Epigenetic Alterations | In conclusion, our findings further implicate "metabolic" genes or pathways in breast cancer that are disrupted by epigenetic mechanisms and could provide new avenues for understanding this disease in a new context. | 26152288 |
| Primary malignant neoplasm | Epigenetic Alterations | Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis. | 26152361 |
| Psychiatric | Epigenetic Alterations | The results support increasing optimism that epigenetic regulation of key neuroendocrine systems might help explain hitherto unfathomable individual differences in susceptibility to psychiatric symptom profiles. | 26152664 |
| Laryngeal Squamous Cell Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Altered microRNA expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC). | 26153151 |
| Carcinoma of lung | Epigenetic Alterations | High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer. | 26156018 |
| Primary malignant neoplasm | Epigenetic Alterations | In conclusion, our results show that copy number variation may be an important mechanism of upregulation/downregulation of miRNAs in cancer and suggest an oncogenic role for DROSHA. | 26156018 |
| Admitting diagnosis | Epigenetic Alterations | Recently it has been shown that aberrant epigenetic processes including acetylation are associated with the development of AD. | 26159193 |
| Alzheimers Disease | Epigenetic Alterations | We examined whether altered DNA methylation of the MAPT promoter, with its potential to modulate gene expression, was a common phenomenon in Alzheimers disease patients with differing aetiologies. | 26159201 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Genome-scale long noncoding RNA expression pattern in squamous cell lung cancer. | 26159226 |
| Metastatic hepatocellular carcinoma | Epigenetic Alterations | Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition. | 26160837 |
| Primary malignant neoplasm | Epigenetic Alterations | Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate diverse cellular processes, including cell growth, differentiation, apoptosis, and cancer progression. | 26160837 |
| Neoplasms | Epigenetic Alterations | Lethal-7 (let-7) is a tumour suppressor miRNA which acts by down-regulating several oncogenes including KRAS. | 26162609 |
| Hypertensive disease | Epigenetic Alterations | Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension. | 26162916 |
| Failure | Epigenetic Alterations | There is growing evidence that angiogenesis and microRNAs are involved in PAH-associated RV failure. | 26162916 |
| Fracture | Epigenetic Alterations | Serum Circulating MicroRNAs as Biomarkers of Osteoporotic Fracture. | 26163235 |
| Diffuse Scleroderma | Epigenetic Alterations | Four (miRNA-223, -181b, -342-3p and -184) were differently expressed in lcSSc and dcSSc (false discovery rate < 0.05). | 26163687 |
| Diffuse Scleroderma | Epigenetic Alterations | Circulating miRNA profiles differ between lcSSc and dcSSc patients and between patients with different autoantibodies. | 26163687 |
| Autoimmune Diseases | Epigenetic Alterations | This is the first time autoantibody profiles, disease phenotypes and plasma miRNA profiles have been shown to correlate in an autoimmune disease. | 26163687 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The YAP1 oncogene contributes to bladder cancer cell proliferation and migration by regulating the H19 long noncoding RNA. | 26163939 |
| Malignant Neoplasms, Malignant neoplasm of urinary bladder | Epigenetic Alterations | Yes-associated protein 1 (YAP1) and long noncoding RNA H19 act as potent oncogenes in many human cancers, but little is known about their roles in bladder cancer or their relationship with each other. | 26163939 |
| Crohn Disease | Epigenetic Alterations | MicroRNAs Classify Different Disease Behavior Phenotypes of Crohns Disease and May Have Prognostic Utility. | 26164662 |
| Inflammation | Epigenetic Alterations | We found a suite of miRNAs, including miR-31-5p, miR-215, miR-223-3p, miR-196b-5p, and miR-203 that stratify patients with CD according to disease behavior independent of the effect of inflammation. | 26164662 |
| Right arm | Epigenetic Alterations | Here, we show that TXNDC5 is directly targeted by microRNA (miR)-573, and TXNDC5, in turn, mediates the suppressive effect of miR-573 on the invasion of synovial fibroblasts of RA (RASFs). | 26166764 |
| Muscle, Smooth, Vascular | Epigenetic Alterations | MicroRNA-1 regulates the proliferation of vascular smooth muscle cells by targeting insulin-like growth factor 1. | 26166810 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer. | 26169690 |
| Breast Carcinoma | Epigenetic Alterations | Here we characterize the DNA methylome of endocrine sensitivity and demonstrate the potential impact of differential DNA methylation on endocrine response in breast cancer. | 26169690 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Unique microRNAs in lung adenocarcinoma groups according to major TKI sensitive EGFR mutation status. | 26170125 |
| Malignant Neoplasms, Carcinoma of lung | Epigenetic Alterations | Altered expression of microRNAs(miRNAs) in human malignancies have been well recognized as diagnostic and prognostic indicators, including lung cancer. | 26170125 |
| Neoplasms | Epigenetic Alterations | Higher expression levels of three miRNAs were positively related to poor tumor differentiation. | 26170125 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Consequently, further studies of the biology of miRNAs may lead to diagnostic and prognostic biomarkers in pulmonary adenocarcinoma. | 26170125 |
| Progeria | Epigenetic Alterations | Cells from HGPS patients show several nuclear abnormalities including aberrant morphology, nuclear stiffening and loss of epigenetic modifications including heterochromatin territories. | 26171741 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | MiRNAs are deregulated in different tumors including gastric cancer (GC) and have potential diagnostic and prognostic implications. | 26172537 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-18a modulates P53 expression by targeting IRF2 in gastric cancer patients. | 26173586 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-18a (miR-18a) has been reported to be upregulated in gastric cancer (GC) tissues compared with normal gastric tissues. | 26173586 |
| Parkinson Disease | Epigenetic Alterations | L-dopa increases a-synuclein DNA methylation in Parkinsons disease patients in vivo and in vitro. | 26173746 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The potential role of microRNA-31 expression in early colorectal cancer. | 26173758 |
| Malignant Neoplasms, Colorectal Cancer Pathway | Epigenetic Alterations | The expression of microRNA-31 (miR-31) has been implicated in the progression of some human malignancies including colorectal cancer. | 26173758 |
| Primary malignant neoplasm | Epigenetic Alterations | Oxidative stress related DNA methylation may therefore be associated (causally or as a by-product) with cancer. | 26173806 |
| Primary malignant neoplasm | Epigenetic Alterations | In the ESTHER baseline sample, the hazard ratio for cancer development in 11 years of follow-up comparing bottom and top quartile of DNA methylation at cg10342304 was 1.86 (95%-confidence-interval 1.01-3.43). | 26173806 |
| Primary malignant neoplasm | Epigenetic Alterations | Discovery of a novel epigenetic cancer marker related to the oxidative status of human blood. | 26173806 |
| Primary malignant neoplasm | Epigenetic Alterations | If the observed CpG-cancer association can be successfully replicated by other studies, this epigenetic marker could be an interesting biomarker of cancer risk. | 26173806 |
| Myocardial Ischemia | Epigenetic Alterations | MicroRNAs (miRNAs) play a significant role in ischemic heart disease. | 26175501 |
| Primary malignant neoplasm | Epigenetic Alterations | Correlation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer. | 26181258 |
| Primary malignant neoplasm | Epigenetic Alterations | Understanding the origin and inheritance of epimutations is important for assessing cancer risk in affected families. | 26181641 |
| Primary malignant neoplasm | Epigenetic Alterations | Constitutional hypermethylation of 1 allele throughout the soma (constitutional epimutation) is an accepted mechanism of cancer predisposition. | 26181641 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We report a 29-year-old man with early-onset colorectal cancer who showed a constitutional MLH1 epimutation (approximately 50% of alleles methylated and allele-specific loss of MLH1 expression) that was stable over a 16-year period. | 26181641 |
| Primary malignant neoplasm | Epigenetic Alterations | Mosaic Epigenetic Inheritance as a Cause of Early-Onset Colorectal Cancer. | 26181641 |
| Sjogrens Syndrome", Autoimmune Diseases, Perceived stress scale, Lupus Erythematosus | Epigenetic Alterations | Beyond genetics, epigenetics alterations and especially those related to DNA methylation, play key roles in the pathogenesis of autoimmune diseases such as primary Sjogrens syndrome (pSS) and systemic lupus erythematosus. | 26183421 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | A potential signature of eight long non-coding RNAs predicts survival in patients with non-small cell lung cancer. | 26183581 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulated evidence suggests that dysregulated expression of long non-coding RNAs (lncRNAs) may play a critical role in tumorigenesis and prognosis of cancer, indicating the potential utility of lncRNAs as cancer prognostic or diagnostic markers. | 26183581 |
| Primary malignant neoplasm | Epigenetic Alterations | JARID1B is an epigenetic factor with reported oncogenic potential in various cancer types. | 26184998 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Low expression of circulating microRNA-328 is associated with poor prognosis in patients with acute myeloid leukemia. | 26185105 |
| Hollings Cancer Center | Epigenetic Alterations | As we reported previously, microRNA-491 (miR-491) is lower expressed in poorly differentiated HCC tissues relative to well-differentiated HCC tissues. | 26188902 |
| Hepatitis, Fibrosis Assessment, Hepatitis C, Fibrosis, Liver | Epigenetic Alterations | microRNA changes in liver tissue associated with fibrosis progression in patients with hepatitis C. Accumulating evidence indicates that microRNAs play a role in a number of disease processes including the pathogenesis of liver fibrosis in hepatitis C infection. | 26189820 |
| Fibrosis Assessment | Epigenetic Alterations | Our goal is to add to the accruing information regarding microRNA deregulation in liver fibrosis to increase our understanding of the underlying mechanisms of pathology and progression. | 26189820 |
| Hepatitis C, Fibrosis Assessment | Epigenetic Alterations | We used next generation sequencing to profile all detectable microRNAs in liver tissue and serum from patients with hepatitis C, stages F1-F4 of fibrosis. | 26189820 |
| Hepatitis C, Fibrosis Assessment | Epigenetic Alterations | We found altered expression of several microRNAs, in particular, miR-182, miR199a-5p, miR-200a-5p and miR-183 were found to be significantly upregulated in tissue from liver biopsies of hepatitis C patients with advanced fibrosis, stage F3 and F4, when compared with liver biopsies from patients with early fibrosis, stages F1 and F2. | 26189820 |
| Fibrosis Assessment | Epigenetic Alterations | We also found miR-148-5p, miR-1260b, miR-122-3p and miR-378i among the microRNAs most significantly down-regulated from early to advanced fibrosis of the liver. | 26189820 |
| Fibrosis Assessment | Epigenetic Alterations | Adding measurements of tissue microRNAs acquired during routine biopsies will continue to increase our knowledge of underlying mechanisms of fibrosis. | 26189820 |
| Liver carcinoma | Epigenetic Alterations | Clinical implication of long non-coding RNA NEAT1 expression in hepatocellular carcinoma patients. | 26191242 |
| Malignant Neoplasms | Epigenetic Alterations | NEAT1 (nuclear paraspeckle assembly transcript 1, also known as MENe/b), a novel long non-coding RNA (lncRNA), serves as a crucial regulator in several cancers. | 26191242 |
| Stomach Carcinoma | Epigenetic Alterations | Downregulation of long noncoding RNA ZMAT1 transcript variant 2 predicts a poor prognosis in patients with gastric cancer. | 26191264 |
| Solitary Pulmonary Nodule | Epigenetic Alterations | MicroRNA-144 regulates proliferation, invasion, and apoptosis of cells in malignant solitary pulmonary nodule via zinc finger E-box-binding homeobox 1. | 26191328 |
| Neoplasms | Epigenetic Alterations | Recurrent mutations were most frequently located in the RNA helicase gene DDX3X (21/105 subjects, 20.0%), tumor suppressors (TP53 and MGA), JAK-STAT-pathway molecules (STAT3 and STAT5B) and epigenetic modifiers (MLL2, ARID1A, EP300 and ASXL3). | 26192917 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic Inactivation of BRCA1 Through Promoter Hypermethylation and Its Clinical Importance in Triple-Negative Breast Cancer. | 26195437 |
| Breast Carcinoma | Epigenetic Alterations | The epigenetic inactivation of BRCA1 expression might thus play an important role in sporadic breast cancer cases. | 26195437 |
| Malignant neoplasm of urinary bladder, Metastasis | Epigenetic Alterations | Long noncoding RNA 19 (H19) has been shown to promote bladder cancer cell proliferation and metastasis. | 26198047 |
| Acute myocardial infarction | Epigenetic Alterations | Expression of circulating microRNAs in patients with ST segment elevation acute myocardial infarction. | 26198874 |
| Metastasis | Epigenetic Alterations | miRNA-197 and miRNA-184 are associated with brain metastasis in EGFR-mutant lung cancers. | 26199015 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNAs (miRNAs) are frequently deregulated in lung cancer. | 26199015 |
| Stomach Carcinoma, Neoplasm Metastasis | Epigenetic Alterations | Together, our results imply that loss of RACK1 in gastric cancer links epigenetics to inflammatory cytokines to promote tumor metastasis. | 26199092 |
| Neoplasms | Epigenetic Alterations | microRNA (miRNA; miR) array identified that RACK1 modulated the expression of a series of miRNAs, including the miR-302 cluster, and RACK1 modulated the IL8 expression and tumor invasion through miRNA-302c. | 26199092 |
| Carcinoma of lung, Lung diseases | Epigenetic Alterations | Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer. | 26200272 |
| Carcinoma of lung | Epigenetic Alterations | In conclusion, we identified a serum 4-miRNA signature that discriminated with high accuracy lung cancer patients from NC. | 26202143 |
| Pulmonary Hypertension | Epigenetic Alterations | rs2910164 Polymorphism Confers a Decreased Risk for Pulmonary Hypertension by Compromising the Processing of microRNA-146a. | 26202355 |
| Sebaceous adenoma, Sebaceous Adenocarcinoma | Epigenetic Alterations | Sebaceous carcinoma exhibits an miRNA expression profile distinct from that of sebaceous adenoma, implicating dysregulation of NF-kB and PTEN (targets of miR-486-5p) and TGF-b signaling (target of miR-211) in the pathogenesis of sebaceous carcinoma. | 26203913 |
| Sebaceous Adenocarcinoma | Epigenetic Alterations | Distinct pathways in the pathogenesis of sebaceous carcinomas implicated by differentially expressed microRNAs. | 26203913 |
| Sebaceous adenoma, Sebaceous Adenocarcinoma, Ocular Sebaceous Carcinoma | Epigenetic Alterations | To describe differentially expressed microRNAs (miRNAs) in a series of periocular sebaceous carcinomas compared with sebaceous adenomas in order to identify pathways driving the pathogenesis of sebaceous carcinoma. | 26203913 |
| Sebaceous adenoma, Sebaceous Adenocarcinoma | Epigenetic Alterations | Serial testing and validation confirmed overexpression of 2 miRNAs previously reported to be oncogenic, miR-486-5p (4.4-fold; P = 2.4 x 10-8) and miR-184 (3.5-fold; P = 1.7 x 10-6), in sebaceous carcinoma compared with sebaceous adenoma and downregulation of 2 miRNAs previously reported to have tumor-suppressive properties, miR-211 (-5.8-fold; P = 2.3 x 10-9) and miR-518d (-4.5-fold; 6.7 x 10-5), in sebaceous carcinoma compared with sebaceous adenoma. | 26203913 |
| Sebaceous adenoma, Sebaceous Adenocarcinoma | Epigenetic Alterations | The identification of miRNAs whose expression is altered in sebaceous carcinoma compared with sebaceous adenoma provides a novel entry point for a more comprehensive understanding of the molecular-genetic alterations pivotal to the development of sebaceous carcinoma. | 26203913 |
| Concomitant Medication Submission Domain | Epigenetic Alterations | We identified five miRNAs (miR-1225-5p, miR-320c, miR-1202, miR-1207-5p, and miR-4270) with high expression in MA samples, the PLF of serosa-invasive GC, and the CM of a highly metastatic GC cell line; these candidate miRNA species appear to be related to peritoneal dissemination. | 26208314 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer. | 26208314 |
| Metastasis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The microRNA-1246 promotes metastasis in non-small cell lung cancer by targeting cytoplasmic polyadenylation element-binding protein 4. | 26209100 |
| CHOANAL ATRESIA, POSTERIOR, human papillomavirus | Epigenetic Alterations | In 129 PCa patients who underwent ultrasound-guided needle prostate biopsy and subsequent radical prostatectomy from 1987 to 1999 at the University Hospital of Careggi, we evaluated: (1) mRNA expression of the serine 2 (TMPRSS2): erythroblastosis virus E26 oncogene homolog (ERG); (2) expression of matrix metalloproteinases (MMP)-2 and 9 (epithelial and stromal); (3) expression of androgen receptor; (4) expression of prognostic marker Ki67 (MIB1); (5) presence and typing of human papilloma virus; (6) DNA methylation of CpG islands of several genes involved in PCa progression. | 26210155 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidence indicates that dysregulated microRNA-3651(miR-3651) is involved in tumorigenesis and cancer progression. | 26210449 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Combination of serum miRNAs with Cyfra21-1 for the diagnosis of non-small cell lung cancer. | 26213369 |
| Primary malignant neoplasm | Epigenetic Alterations | It has been proposed that miRNA expression studies might be used as diagnostic, prognostic marker in cancer. | 26214773 |
| Chondrosarcoma | Epigenetic Alterations | miRNA expression data produced in our study may contribute future chondrosarcoma diagnosis and therapy. | 26214773 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | Dysregulated expression of many miRNAs has also been associated with multiple human diseases, such as cancer. | 26214773 |
| Clinical Coordinator | Epigenetic Alterations | A newly proposed integrated pathway comprising traditional, alternate, and serrated pathways by genetic and epigenetic factors was defined recently and hypothesized to play a role in the pathogenesis of CRC; however, to the authors knowledge, there is a paucity of information regarding these proposed molecular pathways in different ethnic groups. | 26218848 |
| MS gene | Epigenetic Alterations | Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals. | 26220975 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | MicroRNA-330-5p as a Putative Modulator of Neoadjuvant Chemoradiotherapy Sensitivity in Oesophageal Adenocarcinoma. | 26221725 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNA/miR) function to regulate gene and protein expression and play a causal role in cancer development and progression. | 26221725 |
| Carcinoma of lung | Epigenetic Alterations | Fifty miRNAs previously ranked for their ability to distinguish lung cancer tissue from normal were assayed by RT-qPCR using 45 paired tumor-normal samples. | 26223535 |
| Neoplasms | Epigenetic Alterations | Novel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been confirmed to play crucial regulatory roles in tumor progression. | 26224446 |
| SERPINB3 wt Allele | Epigenetic Alterations | According to microRNA array, 16 miRNAs were upregulated and 10 were downregulated in OSCC patient sera. | 26224475 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Deregulation of microRNAs (miRNAs) is essential to tumor development, and serum miRNA profiles have been reported in several cancers. | 26224475 |
| Pulmonary arterial hypertension | Epigenetic Alterations | Bromodomain-Containing Protein 4: The Epigenetic Origin of Pulmonary Arterial Hypertension. | 26224795 |
| Primary malignant neoplasm | Epigenetic Alterations | In cancer, increased expression of the epigenetic reader bromodomain-containing protein 4 (BRD4) sustains cell survival and proliferation. | 26224795 |
| Secondary malignant neoplasm of prostate | Epigenetic Alterations | The roles of dysregulated microRNAs in prostate cancer metastasis are still unknown. | 26227059 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | We hypothesized that anti-citrullinated protein antibodies (ACPAs) could affect the expression of miRNAs in monocytes and contribute to the inflammatory responses in rheumatoid arthritis (RA). | 26227320 |
| acetyl 4-aminosalicylic acid | Epigenetic Alterations | Ten miRNAs exhibited differential expression in U937 cells after co-cultured with ACPAs compared with human IgG. | 26227320 |
| DICER1 protein, human, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas. | 26227789 |
| Malignant Neoplasms, Carcinoma of lung | Epigenetic Alterations | Altered microRNA expression has been found to be a common feature of several cancers, including lung carcinomas. | 26227789 |
| DICER1 protein, human | Epigenetic Alterations | The biogenesis and maturation of microRNAs is known to be mediated by the ribonucleases Drosha, Dicer and Ago2. | 26227789 |
| Myeloid Leukemia, Chronic, Neoplasms | Epigenetic Alterations | MicroRNA-320a acts as a tumor suppressor by targeting BCR/ABL oncogene in chronic myeloid leukemia. | 26228085 |
| Malignant Neoplasms, Myeloid Leukemia, Chronic, Metastasis, Neoplasms | Epigenetic Alterations | Accumulating evidences demonstrated that the induction of epithelial-mesenchymal transition (EMT) and aberrant expression of microRNAs (miRNAs) are associated with tumorigenesis, tumor progression, metastasis and relapse in cancers, including chronic myeloid leukemia (CML). | 26228085 |
| SF3B1 wt Allele | Epigenetic Alterations | The combination of genetic and epigenetic markers was used in much more patients with MDS (62.5% [35/56]) than the use of genetic markers only (51.79% [29/56]). | 26228212 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Downregulation of serum microRNA-205 as a potential diagnostic and prognostic biomarker for human glioma. | 26230475 |
| Primary malignant neoplasm | Epigenetic Alterations | OBJECT Circulating microRNAs (miRNAs) are a new class of highly promising cancer biomarkers. | 26230475 |
| Crohn Disease | Epigenetic Alterations | Circulating microRNAs as biomarkers of adult Crohns disease. | 26230660 |
| Hollings Cancer Center | Epigenetic Alterations | A miRNA integrated-signature of 5 upregulated and 8 downregulated miRNAs was identified from 26 published datesets in HCC using robust rank aggregation method. | 26231037 |
| Hollings Cancer Center | Epigenetic Alterations | A miRNA based score using LASSO regression model provided a high accuracy for identifying HCC tissue (AUC = 0.982): HCC risk score = 0.180E_miR-221 + 0.0262E_miR-21 - 0.007E_miR-223 - 0.185E_miR-130a. | 26231037 |
| Colonic Neoplasms | Epigenetic Alterations | Moreover, we further validated the confirmed miRNAs in a clinical setting using qRT-PCR and Tumor Cancer Genome Atlas (TCGA) dataset. | 26231037 |
| Neoplasms | Epigenetic Alterations | Furthermore, expression of 5 miRNAs (miR-222, miR-221, miR-21 miR-214 and miR-130a) correlated with pathological tumor grade. | 26231037 |
| Precursor T-cell lymphoblastic lymphoma | Epigenetic Alterations | Upregulation of miRNA-17 and miRNA-19 is associated with unfavorable prognosis in patients with T-cell lymphoblastic lymphoma. | 26231295 |
| Osteoarthritis, Knee | Epigenetic Alterations | Altered microRNA expression profile in synovial fluid from patients with knee osteoarthritis with treatment of hyaluronic acid. | 26232909 |
| Degenerative polyarthritis | Epigenetic Alterations | Further bioinformatics prediction by mirPath indicated that the differential miRNA signatures in synovial fluid extracted from the OA patients demonstrated primarily upregulation of the PI3K-Akt signaling pathway, mitogen-activated protein kinase signaling pathway, regulation of autophagy, mRNA surveillance pathway, and B cell receptor signaling pathway. | 26232909 |
| Degenerative polyarthritis | Epigenetic Alterations | Forty-three miRNAs (21 overexpressed miRNAs and 22 underexpressed miRNAs) were differentially expressed in OA patients before and after treatment with HA (P < 0.05, false discovery rate corrected). | 26232909 |
| Degenerative polyarthritis | Epigenetic Alterations | Our results demonstrated that dysregulation in miRNAs in synovial fluid from OA patients and their affected biologic cellular processes might play important role in OA pathogenesis and HA-mediated therapeutics. | 26232909 |
| Stomach Carcinoma | Epigenetic Alterations | Circulating microRNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer. | 26233325 |
| Metastasis | Epigenetic Alterations | Based on the preliminary experiments, miR-203 was selected as the candidate serum miRNA that was most closely associated with metastasis. | 26233325 |
| Metastasis | Epigenetic Alterations | MicroRNAs (miRNAs) relating to the epithelial-mesenchymal transition (EMT) control GC progression and metastasis. | 26233325 |
| Carcinoma of lung | Epigenetic Alterations | To find the association of two pre-miRNA polymorphisms with risk of lung cancer in North Indians. | 26235181 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-486 as a Biomarker for Early Diagnosis and Recurrence of Non-Small Cell Lung Cancer. | 26237047 |
| Carcinoma of lung | Epigenetic Alterations | MiRNA (miR)-486 and miR-150 were found to significantly distinguish lung cancer patients from healthy volunteers. | 26237047 |
| Primary malignant neoplasm, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Altered expressions in many cancer types including NSCLC and stable existence in plasma make microRNAs (miRNAs) a group of potentially useful biomarkers for clinical assessments of patients with NSCLC. | 26237047 |
| Neoplasms | Epigenetic Alterations | Expression of ten miRNAs in the plasma and tumor sections of the patients was detected by quantitative real-time polymerase chain reaction. | 26237047 |
| methionine, Stomach Carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-34a attenuates the proliferation, invasion and metastasis of gastric cancer cells via downregulation of MET. | 26238271 |
| Stomach Carcinoma | Epigenetic Alterations | As a direct target of p53, the functions of microRNA (miR)-34a are important, but controversial, in the progression of gastric cancer. | 26238271 |
| Dental Plaque | Epigenetic Alterations | MicroRNA deregulation in symptomatic carotid plaque. | 26238333 |
| Medical Device Material Rupture, Plaque (lesion) | Epigenetic Alterations | Genetic mechanisms and especially the roles played by microRNAs in the regulation of plaque destabilization and rupture are mostly unknown. | 26238333 |
| atherosclerotic | Epigenetic Alterations | After isolation of total RNA from atherosclerotic plaques, microRNAs were quantified by real-time polymerase chain reaction. | 26238333 |
| Weight decreased, Cerebrovascular accident | Epigenetic Alterations | Epigenetic Changes in the Methylation Patterns of KCNQ1 and WT1 after a Weight Loss Intervention Program in Obese Stroke Patients. | 26238466 |
| Cerebrovascular accident, Obesity, Inflammation | Epigenetic Alterations | Epigenetic mechanisms could be involved in obesity, inflammation and stroke. | 26238466 |
| Carcinoma of lung | Epigenetic Alterations | A miRNA microarray was used to profile miRNAs of lung cancer tissues. | 26238736 |
| Primary malignant neoplasm | Epigenetic Alterations | Thus, the results are of importance for clinical investigators and for those who design miRNA-based novel cancer therapeutics. | 26238736 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | It was identified that 33 miRNAs with >2.0-fold change and FDR <0.05 were differentially expressed between the adjacent non-cancerous lung tissues and non-small cell lung cancers NSCLCs (P<0.005). | 26238736 |
| Carcinoma of lung, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Validation of significant miRNAs in independent 40 paired NSCLC tissues demonstrated that the expression level of miR-486-5p and miR-30a-5p was significantly downregulated in another 40 paired lung cancer tissues. | 26238736 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Taken together, the results provided strong evidence of the possible involvement of miRNAs in the development and progression of NSCLC. | 26238736 |
| Meningioma | Epigenetic Alterations | Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma. | 26240495 |
| Diabetic Retinopathy | Epigenetic Alterations | Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy. | 26241401 |
| Meningioma | Epigenetic Alterations | Expression of Stem Cell Marker Nestin and MicroRNA-21 in Meningiomas. | 26242334 |
| Degenerative polyarthritis | Epigenetic Alterations | Signature of microRNA expression during osteogenic differentiation of bone marrow MSCs reveals a putative role of miR-335-5p in osteoarthritis. | 26243143 |
| Degenerative polyarthritis | Epigenetic Alterations | We describe the existence of a correlation between miR-335-5p expression and OA indicating the putative role of this miRNA in OA features. | 26243143 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Expression and role of oncogenic miRNA-224 in esophageal squamous cell carcinoma. | 26245343 |
| cervical cancer | Epigenetic Alterations | These studies support the concept that epigenetic changes regulate expression of Keap1 in cervical cancer tissues. | 26247201 |
| Tumor necrosis, Periodontitis, Rheumatoid Arthritis, Right arm, TNF protein, human | Epigenetic Alterations | Over-expression of tumor necrosis factor-alpha (TNF-a) plays a pathological role in chronic periodontitis (CP) and rheumatoid arthritis (RA), which might be regulated by the epigenetic mechanism. | 26247485 |
| Prostate Cancer Pathway | Epigenetic Alterations | High-Level Expression of microRNA-21 in Peripheral Blood Mononuclear Cells Is a Diagnostic and Prognostic Marker in Prostate Cancer. | 26247873 |
| Neoplasms | Epigenetic Alterations | Protein arginine methyltransferase-5 (PRMT5), a major type II arginine methyltransferase, is an important epigenetic modifier with oncogene-like properties because of its ability to repress the expression of tumor suppressor genes. | 26248553 |
| Hollings Cancer Center | Epigenetic Alterations | MicroRNA-148a may act as a suppressor miRNA of HCC, and it is therefore a potential prognostic biomarker for HCC patients. | 26248880 |
| Prostate Cancer Pathway | Epigenetic Alterations | Our study suggests that elevated Alu blood DNA methylation levels several years before diagnosis may be associated with an increased prostate cancer risk. | 26250474 |
| Primary central nervous system lymphoma | Epigenetic Alterations | We have previously demonstrated differential expression of microRNAs in cerebrospinal fluid (CSF) samples from patients with PCNSL. | 26250566 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma. | 26250939 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | We sought to identify a serum miRNA expression profile to improve disease surveillance and to predict post-operative disease recurrence for stage II/III colorectal cancer (CRC) patients. | 26250939 |
| Clinical Coordinator | Epigenetic Alterations | The area under the ROC curve (AUC) for the three-miRNA panel was 0.886 (95% CI 0.850-0.921) for discriminating between pre-operative CRC patients and normal subjects and 0.850 (95% CI 0.809-0.891) for discriminating between pre- and post-operative CRC patients. | 26250939 |
| Subarachnoid Hemorrhage, Aneurysmal | Epigenetic Alterations | Gene expression and DNA methylation changes in aneurysmal subarachnoid hemorrhage patients undergoing RIC are involved in coordinated cell cycle and inflammatory responses. | 26251247 |
| Neoplasms | Epigenetic Alterations | miRNAs can either function as tumor suppressor genes or oncogenes in various important pathways. | 26251897 |
| Neoplasms | Epigenetic Alterations | The expression of specific miRNAs has been identified to correlate with tumor prognosis. | 26251897 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Seven miRNAs (miR-16_1*, miR-16_2*, miR-27a, miR-103, miR-185, miR-199, and miR-497) were statistically significantly up-regulated in DLBCL compared to normal germinal cells. | 26251897 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma. | 26252254 |
| Breast Cancer Cell, Neoplasms | Epigenetic Alterations | MicroRNA-122 (miR-122) is considered as a tumor suppressor in human cancer. | 26252254 |
| Hollings Cancer Center | Epigenetic Alterations | MicroRNAs (miRNAs) have been implicated in HCC progression. | 26252254 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-132 (miR-132) has been reported to play a tumor suppressive role in different human malignancies. | 26252738 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-338-3p functions as tumor suppressor in breast cancer by targeting SOX4. | 26252944 |
| ovarian neoplasm, Neoplasms, Carcinoma of lung, Colorectal Carcinoma, Stomach Carcinoma | Epigenetic Alterations | MicroRNA-338-3p (miR-338-3p), a recently discovered miRNA, has been reported to be downregulated and play tumor suppressor roles in gastric cancer, ovarian cancer, colorectal carcinoma and lung cancer by targeting several genes. | 26252944 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation at the 5 position of cytosine (5 mC) is an epigenetic hallmark in cancer. | 26253945 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is a common epigenetic change in cancer. | 26254350 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | However, microRNA (miRNA) regulation by epigenetic alteration, especially CpG island hypermethylation, remains poorly understood in esophageal squamous cell carcinoma (ESCC). | 26254350 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Suppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinoma. | 26254350 |
| Primary malignant neoplasm | Epigenetic Alterations | The miRNA-145 promoter was significantly more hypermethylated in the cancer tissues than in matched normal adjacent esophageal epithelial mucosa (p=0.0042; paired t-test). | 26254350 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | miRNA-145 expression in ESCC seems to be regulated by hypermethylation of the miRNA-145 promoter region. | 26254350 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer. | 26258411 |
| Breast Carcinoma | Epigenetic Alterations | Together, our results show that epigenetic silencing of ITGA2 by miR-373 stimulates breast cancer migration, and miR-373high/ITGA2low may be as a prognosis biomarker for breast cancer patients. | 26258411 |
| Alzheimers Disease | Epigenetic Alterations | These results suggest that a basic defect in Alzheimer disease may be the reduced microRNA-driven increased expression of proteins that may alter the apoptotic/antiapoptotic balance of neurons. | 26258756 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | Taken together, our results demonstrate thatmiR-99b-5p is differently expressed in primary CRC and liver metastasis and functions as a tumor-suppressive microRNA in metastatic CRC. | 26259252 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway | Epigenetic Alterations | miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR. | 26259252 |
| Secondary malignant neoplasm of liver, Clinical Coordinator | Epigenetic Alterations | In this study we screened the different expression profiles of microRNAs (miRNAs) on the development of liver metastasis in CRC patients. | 26259252 |
| Clinical Coordinator, Ulcerative Colitis | Epigenetic Alterations | Key gene expressions of the histone modification enzyme were assessed and compared in CRC, UC and control groups using the RT-PCR array technique. | 26259750 |
| Clinical Coordinator, Carcinogenesis | Epigenetic Alterations | Histone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC. | 26259750 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancer. | 26260454 |
| Carcinoma, Ovarian Epithelial | Epigenetic Alterations | Serous epithelial ovarian cancer (SEOC) is a highly metastatic disease and its progression has been implicated with microRNAs. | 26260454 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs have become recognized as key players in the development of malignancy. | 26261507 |
| Neoplasms | Epigenetic Alterations | Together, our data provide a novel epigenetic mechanism regulating tumor cell invasion and EMT, and provide a biomolecule for ccRCC diagnosis and prognosis. | 26261509 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Circulating microRNAs (miRNAs) were recognized to be potential non-invasive biomarkers for colorectal cancer (CRC) detection and prediction. | 26261602 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The potential of plasma miRNAs for diagnosis and risk estimation of colorectal cancer. | 26261602 |
| Clinical Coordinator | Epigenetic Alterations | Meanwhile, the association of the expression of plasma miRNAs with the risk of CRC patients has rarely been analyzed. | 26261602 |
| Clinical Coordinator | Epigenetic Alterations | Sensitivity and specificity were employed to evaluate the diagnostic value of miRNAs for CRC. | 26261602 |
| Clinical Coordinator | Epigenetic Alterations | Univariate and multivariate logistic regression were employed to analyze the association between miRNAs expression and CRC risk. | 26261602 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Hox transcript antisense intergenic RNA (HOTAIR) is a long non-coding RNA, its overexpression has been documented in various human solid tumor and it can be considered as a potential cancer biomarker. | 26261618 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | miRNA-21 and miRNA-34a Are Potential Minimally Invasive Biomarkers for the Diagnosis of Pancreatic Ductal Adenocarcinoma. | 26262588 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | Two Different Serum MiRNA Signatures Correlate with the Clinical Outcome and Histological Subtype in Pleural Malignant Mesothelioma Patients. | 26262875 |
| Hollings Cancer Center | Epigenetic Alterations | MiR-193a-3p may be a tumor-suppressive miRNA which is down-regulated in HCC tissues. | 26263159 |
| Hepatitis B, Liver carcinoma | Epigenetic Alterations | Circulating microRNAs as biomarkers for diagnosis of early hepatocellular carcinoma associated with hepatitis B virus. | 26264553 |
| Primary malignant neoplasm | Epigenetic Alterations | Longitudinal Study of DNA Methylation of Inflammatory Genes and Cancer Risk. | 26265203 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation modification, one of the epigenetic mechanisms regulating gene expression, is considered a hallmark of cancer. | 26265203 |
| Neoplasms, Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway. | 26265437 |
| Neoplasms | Epigenetic Alterations | The overexpression of miRNA-1908 significantly promoted anchorage-independent growth in vitro and significantly increased the tumor forming potential in vivo. | 26265437 |
| Glioblastoma Multiforme | Epigenetic Alterations | miRNA-1908 functions as an oncogene in glioblastoma by repressing the PTEN pathway. | 26265437 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer. | 26266366 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | The expression of abnormal microRNA (miRNA, miR) is a ubiquitous feature of colorectal cancer (CRC). | 26266366 |
| Primary malignant neoplasm | Epigenetic Alterations | Differential miRNA rather than snoRNA expression was robust enough to distinguish synchronous cancer from normal mucosa. | 26266366 |
| Clinical Coordinator | Epigenetic Alterations | Function analysis of putative targets suggested that miRNA clusters may modulate multiple effectors of oncogenic pathways involved in the pathogenesis of synchronous CRC. | 26266366 |
| Clinical Coordinator | Epigenetic Alterations | Aberrant miRNA expression profiles could potentially be used as a diagnostic tool for synchronous CRC. | 26266366 |
| Clinical Coordinator | Epigenetic Alterations | Our findings represent the first comprehensive miRNA and snoRNA expression signatures for synchronous CRC, implicating that the miRNAs and snoRNAs may present therapeutic targets for synchronous CRC. | 26266366 |
| Clinical Coordinator | Epigenetic Alterations | We found a global dysregulation of miRNAs, including an oncogenic miR-17-92 cluster and oncosuppressive miR-143-145 cluster, and snoRNAs in synchronous CRC. | 26266366 |
| Neoplasms | Epigenetic Alterations | The target genes of miRNA identified in this study played important roles in tumor signaling pathways, and their detailed functions could be further studied so as to explore novel neuroglioma therapies. | 26269115 |
| Endothelial dysfunction | Epigenetic Alterations | Plasma miRNAs may be useful as potential screening tools for the presence of endothelial dysfunction in children and may reveal endothelial dysfunction-relevant target genes. | 26270249 |
| Breast Carcinoma | Epigenetic Alterations | Our results reflect an epigenetic regulation of Rbl2/p130 expression in breast cancer. | 26271034 |
| Lymphoma | Epigenetic Alterations | Deregulation of miRNA-16 and miRNA-155 was limited to lymphoma patients. | 26272105 |
| Small cell carcinoma of lung | Epigenetic Alterations | Our data illuminate that the MDM4rs4245739SNP contributes to SCLC risk and support the notion that gene 3-UTR genetic variants, impacting miRNA-binding, might modify SCLC susceptibility. | 26274820 |
| Small cell carcinoma of lung | Epigenetic Alterations | A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer. | 26274820 |
| Admitting diagnosis | Epigenetic Alterations | DNA methylation is altered in AD patients, suggesting that epigenetic mechanisms play a role in AD pathophysiology. | 26275347 |
| Breast Carcinoma | Epigenetic Alterations | Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1. | 26275461 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Our findings emphasized the potential role of miR-1 as tumor suppressive miRNA in breast cancer. | 26275461 |
| Renal Cell Carcinoma | Epigenetic Alterations | Downregulated ECRG4 is associated with poor prognosis in renal cell cancer and is regulated by promoter DNA methylation. | 26276361 |
| Breast Carcinoma | Epigenetic Alterations | Circulating miRNAs revealed as surrogate molecular signatures for the early detection of breast cancer. | 26276721 |
| Breast Carcinoma | Epigenetic Alterations | Results showed differential pattern of expressions of these miRNAs in multiple cohorts, however in early stage breast cancer, miR-106a-5p and miR-454-3p were upregulated (p < 0.05), miR-195-5p and miR-495 were downregulated (p < 0.05) in PBMCs. | 26276721 |
| Primary malignant neoplasm | Epigenetic Alterations | In addition, these miRNAs were also significantly associated with cancer and ErbB signaling pathways. | 26276721 |
| Carcinogenesis, Primary malignant neoplasm, Esophageal carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) have a key role in carcinogenesis and cancer development, but the role of miRNAs in the progression of esophageal cancer (EC) remains unclear. | 26279431 |
| Prostate Cancer Pathway | Epigenetic Alterations | Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer. | 26282172 |
| Prostate Cancer Pathway | Epigenetic Alterations | Here, we report the identification of 145 previously unannotated intergenic long noncoding RNA transcripts (lncRNA) or isoforms that are associated with prostate cancer or CRPC. | 26282172 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Exosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients. | 26284486 |
| Depression, CTCAE | Epigenetic Alterations | The regulation of the brain-derived neurotrophic factor (BDNF) is important for depression pathophysiology and epigenetic regulation of the BDNF gene may be involved. | 26285129 |
| Acute Promyelocytic Leukemia | Epigenetic Alterations | Mutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide. | 26285909 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27. | 26291312 |
| Malignant Neoplasms | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) are known to regulate the development and progression of various cancers. | 26291312 |
| Adenoid Cystic Carcinoma | Epigenetic Alterations | Expression of miRNAs in adenoid cystic carcinomas of the breast and salivary glands. | 26293217 |
| Hyperhomocysteinemia | Epigenetic Alterations | Suboptimal B vitamins status and hyperhomocysteinemia are associated with altered DNA methylation and telomere length. | 26293976 |
| ovarian neoplasm | Epigenetic Alterations | Compared with scramble miRNA overexpression of miR-24 was validated to remarkably induce ovarian cancer cells apoptosis. | 26296081 |
| Disease | Epigenetic Alterations | Substantial evidence has shown that microRNAs (miRNAs) may be causally linked to the occurrence and progression of human diseases. | 26296081 |
| Disease | Epigenetic Alterations | Ninety-nine miRNAs were scanned for possible functional association with 2223 MeSH-defined human diseases. | 26296081 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Epigenetic Alterations | CC-486 (oral azacitidine) is an epigenetic modifier in development for patients with myelodysplastic syndromes and acute myeloid leukemia. | 26296092 |
| Hypoxia | Epigenetic Alterations | RRx-001 is activated by hypoxia and induces the generation of reactive oxygen and nitrogen species that can epigenetically modulate DNA methylation, histone deacetylation, and lysine demethylation. | 26296952 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Epigenetic alterations have been strongly associated with tumour formation and resistance to chemotherapeutic drugs, and epigenetic modifications are an attractive target in cancer research. | 26296952 |
| Malignant Neoplasms | Epigenetic Alterations | Hypomethylating agents are used to treat cancers driven by aberrant DNA methylation, but their short half-life might limit their activity, particularly in patients with less proliferative diseases. | 26296954 |
| Secondary malignant neoplasm of lung, Primary malignant neoplasm | Epigenetic Alterations | Pulmonary Metastases Exhibit Epigenetic Clonality: Implications for Precision Cancer Therapy. | 26298164 |
| Secondary malignant neoplasm of lung | Epigenetic Alterations | Pulmonary metastases exhibit patient-specific epigenetic clonality, which may be exploited for precision therapies targeting aberrant CT or TS gene expression. | 26298164 |
| Secondary malignant neoplasm of lung | Epigenetic Alterations | PRC-2 may be a shared target for epigenetic therapy of pulmonary metastases. | 26298164 |
| Metastasis | Epigenetic Alterations | Although epithelial-to-mesenchymal transition (EMT), TNF-a and microRNA (miRNA) have been found to play important roles in lymph node metastasis, the underlying molecular mechanism remains unclear. | 26302825 |
| Clinical Coordinator, Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | Here we reported that high expression of microRNA-19a (miR-19a) was associated with lymph node metastasis and played an important role in TNF-a-induced EMT in colorectal cancer (CRC) cells. | 26302825 |
| Aortic Valve Stenosis | Epigenetic Alterations | Circulating microRNA Profiling Needs Further Refinement Before Clinical Use in Patients With Aortic Stenosis. | 26304936 |
| Aortic Valve Stenosis | Epigenetic Alterations | Despite holding great promise, circulating miRNA profiling requires further refinement before translation into clinical use as a biomarker in aortic stenosis. | 26304936 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Epigenetic downregulated ITGBL1 promotes non-small cell lung cancer cell invasion through Wnt/PCP signaling. | 26307393 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | From this dataset, we selected 21 archetypical coding genes and one noncoding RNA, based on statistically significant differences in their expression profile between tumors, for validation by qPCR in a larger cohort of 110 ovarian tumors (71 primary and 39 recurrent) and for testing association of specific genes with time-to-recurrence (TTR). | 26311224 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Molecular tests based on microRNA expression allow a reliable classification of subtypes for NSCLC and can constitute a useful diagnostic strategy in patient selection for targeted therapy. | 26311306 |
| ASAH1 protein, human, Adenocarcinoma of lung (disorder), Squamous cell carcinoma of lung | Epigenetic Alterations | MicroRNAs constitute a promising class of biomarkers and a helpful tool for the distinction between lung adenocarcinoma (AC) and squamous cell lung carcinoma (SCC). | 26311306 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-10b promotes migration and invasion through Hoxd10 in human gastric cancer. | 26311318 |
| CO-methylating acetyl-CoA synthase activity, Depression, CTCAE | Epigenetic Alterations | Adequate antidepressants treatment may effective particularly in those with higher BDNF methylation and then can overcome epigenetic vulnerability for depression persistence in ACS patients. | 26313133 |
| Chronic disease | Epigenetic Alterations | About a tenth of miRNAs plausibly related to chronic disease were reliably detected in stored samples of healthy adults. | 26313271 |
| Pancreatic Intraductal Papillary-Mucinous Adenoma | Epigenetic Alterations | Plasma MicroRNAs as Novel Biomarkers for Patients with Intraductal Papillary Mucinous Neoplasms of the Pancreas. | 26314797 |
| Malignant Neoplasms | Epigenetic Alterations | Data support the importance of miRNAs in the progression of IPMNs to malignancy, and we hypothesized that miRNAs may be shed from IPMN tissues and detected in blood. | 26314797 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA-200 promotes lung cancer cell growth through FOG2-independent AKT activation. | 26314828 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-200 (miR-200) has emerged as a regulator of the PI3K/AKT pathway and cancer cell growth. | 26314828 |
| Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have recently been identified to be involved in various diseases including cancer. | 26314847 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma. | 26315541 |
| Hollings Cancer Center | Epigenetic Alterations | By comparing the expression profiles of miRNAs in different subtypes of HCC, we identified miR-424 as a HCC related miRNA. | 26315541 |
| Squamous cell carcinoma, Neoplasms | Epigenetic Alterations | miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3b in oral squamous cell carcinoma Tca-8113 cells. | 26315788 |
| Squamous cell carcinoma, Carcinogenesis, SERPINB3 wt Allele | Epigenetic Alterations | Dysregulation of microRNAs (miRNAs) has been associated with carcinogenesis in oral squamous cell carcinoma (OSCC). | 26315788 |
| Malignant Neoplasms, Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | The receptor for advanced-glycation end products (RAGE) is upregulated in various cancers and has been associated with tumor progression, but little is known about its expression and regulation by microRNAs (miRNAs) in esophageal squamous cell carcinoma (ESCC). | 26316588 |
| SF3B1 wt Allele | Epigenetic Alterations | Our findings show that the Shh signaling pathway plays a role in the pathogenesis and disease progression of MDS, and proceeds by modulating DNA methylation. | 26317501 |
| palladium | Epigenetic Alterations | Together, these data strengthen the connection between saturated fatty acids, neuroflammation, ER stress, epigenetic alteration and bioenergetic compromise in PD. | 26317511 |
| Astrocytoma | Epigenetic Alterations | Recent studies have shown that astrocytoma formation is the result of the deregulation of several pathways, including the RB/E2F pathway, which is commonly deregulated in various human cancers via genetic or epigenetic mechanisms. | 26317630 |
| Malignant Neoplasms | Epigenetic Alterations | Panobinostat is a radiosensitizing agent and targets the epigenetics of malignancy. | 26317683 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-215 (miR-215) promotes tumor growth in various human malignancies. | 26317904 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Double-negative feedback loop between long non-coding RNA TUG1 and miR-145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells. | 26318860 |
| Glioblastoma Multiforme | Epigenetic Alterations | A five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients. | 26320189 |
| Neoplasms | Epigenetic Alterations | DNA methylation occurs in the displacement loop (D-loop) region of mammals; however, D-loop regions of certain tumor tissue types were found to be de-methylated. | 26323487 |
| Primary malignant neoplasm | Epigenetic Alterations | The involvement of circulating microRNAs (miRNAs) in cancer and their potential as diagnostic and prognostic biomarkers are becoming increasingly known. | 26323574 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-498 is downregulated in non-small cell lung cancer and correlates with tumor progression. | 26323905 |
| Carcinoma of lung, Malignant Neoplasms, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Non-small cell lung cancer (NSCLC) is the most common type of human lung cancer, with highly aggressive, lethal malignancy and microRNAs have already been proven to be associated with NSCLC tumorigenesis. | 26323905 |
| Malignant tumor of colon | Epigenetic Alterations | The microRNA (miRNA), miR-34a is significant in colon cancer progression. | 26324236 |
| Primary malignant neoplasm | Epigenetic Alterations | We originally established Spearman correlation transition model to quantify the cooperativity disorientation associated with the transition from normal to precancerous to cancer tissue, in conjunction with miRNA-mRNA regulatory network and machine learning algorithm to identify genes with prognostic value. | 26325386 |
| Malignant neoplasm of urinary bladder, Hematuria | Epigenetic Alterations | Evaluation of an Epigenetic Profile for the Detection of Bladder Cancer in Patients with Hematuria. | 26327355 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-33b inhibits tumor cell growth and is associated with prognosis in colorectal cancer patients. | 26329295 |
| AMD1 wt Allele, Chronic Kidney Diseases | Epigenetic Alterations | Ocular fundus pathology in patients with BN is similar to the pathology of other CKD, but with significantly more AMD (about four times), probably related to the genetic/epigenetic factors. | 26329737 |
| Rheumatoid Arthritis | Epigenetic Alterations | Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate. | 26330155 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | DNA methylation is an epigenetic mechanism regulating gene expression that has been insufficiently studied in the blood of rheumatoid arthritis (RA) patients, as only T cells and total peripheral blood mononuclear cells (PBMCs) from patients with established RA have been studied and with conflicting results. | 26330155 |
| Secondary malignant neoplasm of female breast, Breast Carcinoma | Epigenetic Alterations | Recent investigations have demonstrated the importance of some miRNA in breast cancer, but the significance of the great majority of miRNA remains largely unclear in breast cancer metastasis. | 26331797 |
| Primary Neoplasm | Epigenetic Alterations | DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence. | 26332453 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Altered DNA methylation in CpG islands of gene promoters has been implicated in prostate cancer (PCa) progression and can be used to predict disease outcome. | 26332453 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | In silico analysis of The Cancer Genome Atlas data confirmed increased DNA methylation of two loci-SRD5A2 and CYP11A1, which also correlated with their decreased expression, in tumors with subsequent BCR development. | 26332453 |
| Retinitis Pigmentosa | Epigenetic Alterations | Overall, increased DNA methylation of SRD5A2 and CYP11A1 related to androgen biosynthesis functions may play a role in BCR after patients RP. | 26332453 |
| Neoplasms | Epigenetic Alterations | Inappropriate DNA methylation is frequently associated with human tumour development, and in specific cases, is associated with clinical outcomes. | 26332997 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Previous reports of DNA methylation in low/intermediate grade non-muscle invasive bladder cancer (NMIBC) have suggested that specific patterns of DNA methylation may have a role as diagnostic or prognostic biomarkers. | 26332997 |
| Stomach Carcinoma | Epigenetic Alterations | Genetic and epigenetic alterations play an important role in gastric cancer (GC) pathogenesis. | 26334097 |
| Stomach Carcinoma | Epigenetic Alterations | Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer. | 26334097 |
| Neoplasms | Epigenetic Alterations | We compared mRNA and miRNA expression levels among 66 gastric tumor and normal adjacent mucosa samples using quantitative real-time reverse transcription PCR. | 26334097 |
| Colorectal Carcinoma | Epigenetic Alterations | Our aim was to identify DNA methylation changes associated with the growth pattern and invasiveness of colorectal cancers (CRCs). | 26334593 |
| Colorectal Neoplasms | Epigenetic Alterations | Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors. | 26334593 |
| Stomach Carcinoma | Epigenetic Alterations | Upregulated expression of long non-coding RNA LINC00982 regulates cell proliferation and its clinical relevance in patients with gastric cancer. | 26334618 |
| Primary malignant neoplasm | Epigenetic Alterations | Emerging evidences indicate that dysregulated long non-coding RNAs (lncRNAs) are implicated in cancer tumorigenesis and progression and might be used as diagnosis and prognosis biomarker or potential therapeutic targets. | 26334618 |
| Primary malignant neoplasm | Epigenetic Alterations | Potential of DNA methylation in rectal cancer as diagnostic and prognostic biomarkers. | 26335606 |
| Colorectal Carcinoma | Epigenetic Alterations | Aberrant DNA methylation is more prominent in proximal compared with distal colorectal cancers. | 26335606 |
| Neoplasms | Epigenetic Alterations | DNA methylation differences were assessed by a targeted DNA microarray for 360 marker candidates between 22 fresh frozen rectal tumour samples and 8 controls and validated by microfluidic high-throughput and methylation-sensitive qPCR in fresh frozen and formalin-fixed paraffin-embedded (FFPE) samples, respectively. | 26335606 |
| Neoplasms | Epigenetic Alterations | Gene expression profiles and microRNAs allow prognostically unfavorable tumors of the mesenchymal subtype to be distinguished. | 26335822 |
| Liver carcinoma | Epigenetic Alterations | Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2. | 26336870 |
| Malignant Neoplasms, Hollings Cancer Center | Epigenetic Alterations | Recent evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including HCC. | 26336870 |
| Cervical Intraepithelial Neoplasia | Epigenetic Alterations | While there is no ideal biomarker for making an early diagnosis of CIN, we hypothesized that levels of specific circulating microRNA (miRNA) species might serve such a role. | 26337190 |
| Kidney Failure, Acute | Epigenetic Alterations | Dysregulated microRNAs involved in contrast-induced acute kidney injury in rat and human. | 26337190 |
| Cervical Intraepithelial Neoplasia | Epigenetic Alterations | Among the 17 miRNAs aberrantly-expressed miRNAs screened from kidney tissue, only six also showed significantly different expression in the plasma of CIN rats. | 26337190 |
| Cervical Intraepithelial Neoplasia | Epigenetic Alterations | Our study provides the first evidence that plasma miRNAs, and especially three miR-30 family members (miR-30a, miR-30c, and miR-30e), might serve as early biomarkers and (or) target candidates for CIN. | 26337190 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Serum microRNA-365 in combination with its target gene TTF-1 as a non-invasive prognostic marker for non-small cell lung cancer. | 26337230 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA (miR)-365 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) cells by targeting thyroid transcription factor 1 (TTF-1). | 26337230 |
| Chronic sinusitis | Epigenetic Alterations | MicroRNA expression profile of mature dendritic cell in chronic rhinosinusitis. | 26337346 |
| Craniosynostosis | Epigenetic Alterations | By comparing miRNA gene expression patterns in 3 types of CRS patients, we have been able to identify candidate miRNAs that might mediate the core pathogenesis of CRS through regulating dendritic cells. | 26337346 |
| Craniosynostosis | Epigenetic Alterations | These miRNAs could serve as potential therapeutic targets for CRS. | 26337346 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | miR9 is an important tumor suppressor microRNA regulated by DNA methylation in various types of cancers. | 26337487 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction. | 26337652 |
| Inflammation, Fibrosis Assessment | Epigenetic Alterations | MicroRNA (miR)-146a and miR-21 have been reported to participate in inflammatory reactions and fibrosis.Excessive inflammation and cardiac fibrosis may play important roles in the development of left ventricular remodeling(LVR). | 26337652 |
| Septicemia | Epigenetic Alterations | Clinical evaluation of circulating microRNA-25 level change in sepsis and its potential relationship with oxidative stress. | 26339334 |
| Septicemia | Epigenetic Alterations | Meanwhile, microRNA-25 level may be associated with oxidative stress in patients with sepsis, and it is expected to become a target for anti-oxidation therapy. | 26339334 |
| Prostate Cancer Pathway | Epigenetic Alterations | Prognostic implications of tissue and serum levels of microRNA-128 in human prostate cancer. | 26339409 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | MicroRNA-128 (miR-128) has been identified as a negative regulator of malignant phenotypes of prostate cancer (PCa) cells. | 26339409 |
| Carcinoma of lung | Epigenetic Alterations | The miRNA-448 and 4478 were significantly overexpressed in lung cancer patients compared to healthy people and these two molecules were qualified for further analysis. | 26341493 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Aberrant expression of microRNAs (miRNAs) in cancer patients compared to healthy people as well as possibility of detection of these molecules in blood samples make them potential biomarkers of various cancers. | 26341493 |
| Carcinoma of lung | Epigenetic Alterations | Using quantitative reverse transcription polymerase chain reaction (qRT-PCR) technique, we assessed expression of studied miRNAs in plasma samples of 90 lung cancer patients and 85 healthy individuals. | 26341493 |
| Carcinoma of lung | Epigenetic Alterations | Our results suggest that the examination of miRNAs could be considered as potential lung cancer, non-invasive biomarkers. | 26341493 |
| ovarian neoplasm | Epigenetic Alterations | Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/b-catenin pathway in human ovarian cancer. | 26341496 |
| Cardiovascular Diseases | Epigenetic Alterations | There is increasing evidence that microRNAs (miRNAs) are deregulated in autoimmune and cardiovascular diseases. | 26342092 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-21 Expression in Primary Breast Cancer Tissue Among Egyptian Female Patients and its Correlation with Chromosome 17 Aneusomy. | 26342497 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-21 (miR-21), on chromosome 17q21.3, is one of the most up-regulated microRNAs in cancer that silences multiple target genes involved in cancer-signaling pathways. | 26342497 |
| Rhabdoid Tumor, Aggressive malignancies | Epigenetic Alterations | Rhabdoid tumors are aggressive malignancies that show loss-of-function mutations of SMARCB1 gene, a member of the SWI/SNF chromatin-remodeling complex controlling gene transcription. | 26342593 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | In parallel, Polycomb group genes (PcGs) are epigenetic repressors implicated in CML progression and in therapy resistance. | 26343356 |
| Primary malignant neoplasm | Epigenetic Alterations | Modest transcriptional changes caused by genetic or epigenetic mechanisms are frequent in human cancer. | 26343801 |
| Cervix carcinoma, Rash and Dermatitis Associated with Chemoradiation, CTCAE | Epigenetic Alterations | Epigenetic Alteration by DNA Methylation of ESR1, MYOD1 and hTERT Gene Promoters is Useful for Prediction of Response in Patients of Locally Advanced Invasive Cervical Carcinoma Treated by Chemoradiation. | 26344356 |
| factor VIII, Chronic Obstructive Airway Disease, Chronic heart failure, Congestive heart failure | Epigenetic Alterations | Plasma miRNA profiling included 137 patients with AHF from 3 different cohorts, 20 with chronic heart failure (CHF), 8 with acute exacerbation of COPD, and 41 healthy controls. | 26345695 |
| factor VIII | Epigenetic Alterations | A further drop in miRNA levels within 48 h after AHF admission was associated with an increased risk of 180-day mortality in a subset of the identified miRNAs. | 26345695 |
| factor VIII | Epigenetic Alterations | Early in-hospital decreasing miRNA levels were predictive for mortality in a subset of miRNAs in patients with AHF. | 26345695 |
| Acute heart failure | Epigenetic Alterations | Signature of circulating microRNAs in patients with acute heart failure. | 26345695 |
| factor VIII, Acute heart failure | Epigenetic Alterations | Our aim was to identify circulating microRNAs (miRNAs) associated with acute heart failure (AHF). | 26345695 |
| factor VIII, Congestive heart failure | Epigenetic Alterations | Plasma levels of miRNAs in patients with AHF were decreased compared with CHF patients or healthy subjects, whereas no significant changes were observed between acute COPD patients and controls. | 26345695 |
| factor VIII | Epigenetic Alterations | Out of these 15 miRNAs, 12 could be confirmed in an additional AHF validation cohort and 7 passed the Bonferroni correction threshold (miR-18a-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-106a-5p, miR-199a-3p, and miR-652-3p, all P < 0.00005). | 26345695 |
| Heart failure | Epigenetic Alterations | Declining levels of circulating miRNAs were associated with increasing acuity of heart failure. | 26345695 |
| Liver carcinoma | Epigenetic Alterations | Low-level expression of microRNA-375 predicts poor prognosis in hepatocellular carcinoma. | 26349912 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | MicroRNAs are predicted to play fundamental roles in the tumorigenesis of hepatocellular carcinoma (HCC). | 26349912 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Effect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer. | 26349991 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We therefore evaluated DNA methylation and transcript levels of two members of the OATP family, OATP3A1 and OATP4A1, that may be involved in E1-S transport in colorectal cancer patients. | 26349991 |
| Carcinogenesis | Epigenetic Alterations | Our results suggest a potential mechanism for OATP3A1 downregulation that involves DNA methylation during colorectal carcinogenesis. | 26349991 |
| Hodgkin Disease | Epigenetic Alterations | DNA methylation patterns in EBV-positive and EBV-negative Hodgkin lymphomas. | 26350502 |
| Malignant Neoplasms, Epstein-Barr Virus Infections | Epigenetic Alterations | Although epigenetic alterations, such as aberrant DNA methylation, are known to contribute to the pathogenesis of various malignancies, little is known about such alterations in HL and their putative relationships with EBV infection. | 26350502 |
| Primary malignant neoplasm, Arthritis | Epigenetic Alterations | MicroRNAs (miRNA), small noncoding RNA molecules, are endogenous regulators of gene expression that have been implicated in the pathogenesis of various diseases such as cancer and arthritis. | 26350536 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNA-16-5p Controls Development of Osteoarthritis by Targeting SMAD3 in Chondrocytes. | 26350536 |
| Hepatitis | Epigenetic Alterations | miRNAs found to be upregulated in severe hepatitis were then quantified by real-time PCR in the expanded cohort of 54 patients. | 26352910 |
| Blood Coagulation Disorders, Acute viral hepatitis | Epigenetic Alterations | Micro RNAs mir-106a, mir-122 and mir-197 are increased in severe acute viral hepatitis with coagulopathy. | 26352910 |
| Fibrosis Assessment | Epigenetic Alterations | Further, we identify concordant histone methylation and acetylation changes in the promoter and putative novel enhancer elements of genes involved in liver fibrosis. | 26353929 |
| Aplastic Anemia | Epigenetic Alterations | Our work describes previously unknown regulatory roles of microRNA in T-cell activation in aplastic anemia, which may open a new perspective for development of effective therapy. | 26354756 |
| Infection caused by Helicobacter pylori, Stomach Carcinoma | Epigenetic Alterations | Helicobacter pylori infection induces aberrant DNA methylation, and methylation levels of several specific marker genes in gastric mucosa are associated with gastric cancer risk. | 26354778 |
| Communicable Diseases | Epigenetic Alterations | In conclusion, smoking habits and green/yellow vegetable intake were associated with DNA methylation levels in gastric mucosae of healthy individuals with current H.pylori infection. | 26354778 |
| Ventricular hypertrophy, Hypertensive disease | Epigenetic Alterations | Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension. | 26358152 |
| Cardiovascular Diseases, Cardiac Hypertrophy | Epigenetic Alterations | MicroRNAs regulate several aspects of physiological and pathologic cardiac hypertrophy, and they represent promising therapeutic targets in cardiovascular disease. | 26358152 |
| Hypertensive disease | Epigenetic Alterations | We assessed the expression levels of the microRNAs miR-1, miR-133a, miR-26b, miR-208b, miR-499, and miR-21, in 102 patients with essential hypertension and 30 healthy individuals. | 26358152 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-related single-nucleotide polymorphism of XPO5 is strongly correlated with the prognosis and chemotherapy response in advanced non-small-cell lung cancer patients. | 26358254 |
| Progeria, Cell Cycle, Loss, DNA Damage | Epigenetic Alterations | Progeria cells display progerin and prelamin A nuclear accumulation, altered histone methylation pattern, heterochromatin loss, increased DNA damage and cell cycle alterations. | 26359359 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer DNA methylation patterns from patients in Manaus, Brazil. | 26363785 |
| Neoplasms | Epigenetic Alterations | DNA methylation is commonly linked with the silencing of the gene expression for many tumor suppressor genes. | 26363785 |
| Malignant Neoplasms | Epigenetic Alterations | As such, determining DNA methylation patterns should aid, in times to come, in the diagnosis and personal treatment for various types of cancers. | 26363785 |
| Hyperglycemia, Inflammation | Epigenetic Alterations | Our results showed the association of hyperglycemia with increased DNA damage and aberrant expression of miRNAs and genes related to several biological processes, such as inflammation, DNA repair, ROS production and antioxidant defense, highlighting the importance of proper glycemic control. | 26364207 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Moreover, the transcriptional expression of miRNAs provided novel information for understanding the regulatory mechanisms involved in the T2D progression. | 26364207 |
| Acute Coronary Syndrome | Epigenetic Alterations | Decision-making microRNAs (miR-124, -133a/b, -34a and -134) in patients with occluded target vessel in acute coronary syndrome. | 26365938 |
| AMD1 wt Allele | Epigenetic Alterations | Differences in miRNA serum profile exist between patients with wet and dry form of AMD, which indicates miRNAs as potential biomarkers of AMD. | 26366973 |
| AMD1 wt Allele | Epigenetic Alterations | Serum MicroRNAs as Potential Biomarkers of AMD. | 26366973 |
| Arteriosclerosis | Epigenetic Alterations | Altered Plasma MicroRNAs as Novel Biomarkers for Arteriosclerosis Obliterans. | 26370316 |
| Airway structure | Epigenetic Alterations | It remains unknown how fine particulate matter (PM2.5) constituents affect differently the fractional concentration of exhaled nitric oxide (FeNO, a biomarker of airway inflammation) and the DNA methylation of its encoding gene (NOS2A). | 26372312 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Our results indicated that organic carbon, element carbon, NO3(-) and NH4(+) might be mainly responsible for the effects of PM2.5 on the decreased NOS2A DNA methylation and elevated FeNO in COPD patients. | 26372312 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Down-regulated MicroRNA 148b expression as predictive biomarker and its prognostic significance associated with clinicopathological features in non-small-cell lung cancer patients. | 26377406 |
| Malignant neoplasm of breast | Epigenetic Alterations | miRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers. | 26378051 |
| Carcinogenesis | Epigenetic Alterations | miRNA deregulation has been found to promote carcinogenesis. | 26378051 |
| Mammary Neoplasms | Epigenetic Alterations | Little is known about miRNA deregulation in hereditary breast tumors as no miRNA expression profiling studies have been performed in normal breast tissue of BRCA1 and BRCA2 mutation carriers. | 26378051 |
| Breast Carcinoma | Epigenetic Alterations | miRNA profiles of 17 BRCA1- and 9 BRCA2-associated breast carcinomas were analyzed using microarrays. | 26378051 |
| Breast Carcinoma | Epigenetic Alterations | Breast carcinomas showed extensive miRNA alteration compared to normal breast tissues in BRCA1 and BRCA2 mutation carriers. | 26378051 |
| Carcinogenesis | Epigenetic Alterations | This study provides a comprehensive insight into the potential role of miRNA deregulation in BRCA1/2-associated breast carcinogenesis. | 26378051 |
| Liver carcinoma | Epigenetic Alterations | Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma. | 26380927 |
| Hollings Cancer Center, Complete atrioventricular block | Epigenetic Alterations | Additionally, the serum levels of circulating microRNAs showed a smaller difference between HCC and either CHB or LC. | 26380927 |
| Hollings Cancer Center | Epigenetic Alterations | This study suggests that serum exosomal microRNAs may be used as novel serological biomarkers for HCC. | 26380927 |
| Stomach Carcinoma | Epigenetic Alterations | Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression. | 26384350 |
| Malignant Neoplasms, Stomach Carcinoma | Epigenetic Alterations | Current evidence suggests that long noncoding RNAs (lncRNAs) may be an important class of functional regulators involved in human cancers development, including gastric cancer (GC). | 26384350 |
| Lichen Planus | Epigenetic Alterations | Diagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients. | 26389700 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Colorectal cancer (CRC) develops through the deregulation of gene expression and the accumulation of epigenetic abnormalities, leading to tumor cell acquisition of malignant features. | 26389729 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) play a critical role in cancer development, where they can act as oncogenes or oncosuppressors. | 26389729 |
| Multiple Myeloma, Extramedullary | Epigenetic Alterations | In this report, we show circulating microRNA distinguishing multiple myeloma patients with extramedullary disease from myeloma patients without such manifestation and from healthy donors. | 26389804 |
| Multiple Myeloma, Extramedullary | Epigenetic Alterations | Circulating microRNA-130a distinguished myeloma patients with extramedullary disease from healthy donors with specificity of 90.0% and sensitivity of 77.1%, patients with extramedullary disease from newly diagnosed multiple myeloma patients with specificity of 77.1% and sensitivity of 34.3% in the test cohort and with specificity of 91.7% and sensitivity of 30.0% in the validation cohort of patients. | 26389804 |
| Sarcoma, Myeloid | Epigenetic Alterations | Circulating microRNA-130a in patients with extramedullary myeloma was associated with bone marrow plasma cells infiltration. | 26389804 |
| Sarcoma, Myeloid, Extramedullary, Neoplasms, Multiple Myeloma | Epigenetic Alterations | Further, microRNA-130a was decreased in bone marrow plasma cells obtained from patients with extramedullary myeloma in comparison to bone marrow plasma cells of myeloma patients without such manifestation, but it was increased in tumor site plasma cells of patients with extramedullary disease compared to bone marrow plasma cells of such patients (p<0.0001). | 26389804 |
| ovarian neoplasm | Epigenetic Alterations | Expression and prognostic significance of microRNA-451 in human epithelial ovarian cancer. | 26390704 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-451 has been proved to be downregulated in many human malignancies and correlated with tumor progression. | 26390704 |
| Squamous cell carcinoma, Metastasis | Epigenetic Alterations | Identification and validation of WISP1 as an epigenetic regulator of metastasis in oral squamous cell carcinoma. | 26391330 |
| Malignant Neoplasms | Epigenetic Alterations | The microRNA, miR-200c, is involved in the tumorigenesis and progression of a variety of cancers. | 26392416 |
| Hepatocarcinogenesis | Epigenetic Alterations | Here, we identified a novel long noncoding RNA (lncRNA) DBH-AS1 involved in the HBx-mediated hepatocarcinogenesis. | 26393879 |
| Hypercholesterolemia | Epigenetic Alterations | Histone acetylation regulates orphan nuclear receptor NR4A1 expression in hypercholesterolaemia. | 26396259 |
| Hypercholesterolemia, Inflammation | Epigenetic Alterations | Thus we conclude that histone acetylation contributes to the regulation of NR4A1 expression in hypercholesterolaemia, and that NR4A1 expression reduces hypercholesterolaemia-induced inflammation. | 26396259 |
| Neoplasms | Epigenetic Alterations | A total of 29 miRNAs were identified to be differentially expressed between AAN-UUC and non-AAN-UUC tissues and these miRNA target genes in FGFR3 and Akt pathways, which regulate cell growth and tumor progression, respectively. | 26397152 |
| Clinical Coordinator | Epigenetic Alterations | We also demonstrated that the CRC-113 gene signature reflected both genetic and epigenetic molecular heterogeneity in CRC patients. | 26397224 |
| Stomach Carcinoma | Epigenetic Alterations | A recent discovery revealed that microRNAs (miRNAs) have an essential effect in the development and progression of gastric cancer (GC). | 26398444 |
| Non-Metastatic Carcinoma | Epigenetic Alterations | Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. | 26398721 |
| Non-Metastatic Carcinoma | Epigenetic Alterations | It was hypothesized that the overexpression of EMP3 was correlated with the downregulation of microRNA-765 (miR-765), an underexpressed miRNA in primary breast carcinoma tissues. | 26398721 |
| 11p15.5 | Epigenetic Alterations | Gene expression, somatic copy number variation of chr11p15.5, and DNA methylation status of three differential methylated regions of the IGF2/H19 locus including the H19 imprinting control region were integratively analyzed. | 26400872 |
| Admitting diagnosis, Impaired T cell function | Epigenetic Alterations | Such epigenetic alteration might contribute to neural cell dysfunction in AD brain. | 26402071 |
| Admitting diagnosis | Epigenetic Alterations | Five miRNA were differentially expressed in CSF of AD patients. | 26402772 |
| Admitting diagnosis | Epigenetic Alterations | In early-onset AD, twelve miRNA were differentially expressed of which lower abundance of miRNA-532-3p remained borderline significant (log10RQ -1.27, p = 0.05). | 26402772 |
| Primary malignant neoplasm | Epigenetic Alterations | Modulation of epigenetic patterns has promising efficacy for treating cancer. | 26404510 |
| Primary malignant neoplasm | Epigenetic Alterations | 5-Hydroxymethylated cytosine (5-hmC) is an epigenetic mark potentially important in cancer. | 26404510 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Here we report that 5-hmC is an epigenetic hallmark of prostate cancer (PCa) progression. | 26404510 |
| Neoplasms | Epigenetic Alterations | Thus, DNA modification directly links the TET2-dependent epigenetic pathway regulated by AR to 5-hmC-mediated tumour progression. | 26404510 |
| Fibrosis Assessment | Epigenetic Alterations | Individual miRNA had moderate diagnostic value for diffuse myocardial fibrosis (AUC: 0.663-0.742), but the diagnostic value was greatly improved (AUC: 0.87) for a combination of 8 miRNAs. | 26404540 |
| Hypertrophic Cardiomyopathy, Fibrosis Assessment | Epigenetic Alterations | Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy. | 26404540 |
| Cardiovascular Diseases | Epigenetic Alterations | Circulating microRNAs may represent novel markers for cardiovascular diseases. | 26404540 |
| Health maintenance, Fibrosis Assessment | Epigenetic Alterations | From the results of this initial array, 16 miRNAs were selected based on their fold changes and relevance to myocardial fibrosis for further validation by Taqman real-time PCR in 55 HCM patients. | 26404540 |
| Health maintenance, Fibrosis Assessment | Epigenetic Alterations | These findings suggest that circulating miRNAs provide attractive candidates as putative biomarkers for diffuse myocardial fibrosis in HCM. | 26404540 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Circulating microRNA expression profile in B-cell acute lymphoblastic leukemia. | 26406572 |
| Acute lymphocytic leukemia | Epigenetic Alterations | Acute lymphoblastic leukemia (ALL) is a highly diverse disease characterized by cytogenetic and molecular abnormalities, including altered microRNA (miRNA) expression signatures. | 26406572 |
| MIR199A1 gene | Epigenetic Alterations | Seventy-seven circulating miRNA differentially expressed: hsa-miR-511, -222, and -34a were overexpressed, whereas hsa-miR-199a-3p, -223, -221, and -26a were underexpressed (p values < 0.005 for both sets). | 26406572 |
| Neoplasms | Epigenetic Alterations | microRNAs (miRNAs) are small non-coding RNAs that play important role in a variety of biological processes, and aberrant expression of miRNA is always associated with tumor progression and invasion. | 26406866 |
| Carcinogenesis | Epigenetic Alterations | Aberrant changes in DNA methylation may be an early event in carcinogenesis. | 26407953 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | miRNA involvement has been observed in almost every type of cancer, including breast cancer. | 26408705 |
| MIR21 gene, Necrosis, iron, Ductal Carcinoma | Epigenetic Alterations | miR21 was down-regulated in 93.3% of patients with necrosis [p=0.017 (Fishers exact test (FE))], while at least one oncogenic miRNA was up-regulated in 87.3% of the patients with invasive ductal carcinoma [p=0.009 (FE)]. | 26408705 |
| Breast Carcinoma | Epigenetic Alterations | Based on this preliminary study, we suggest that these miRNAs, especially let7a and miRNA21, might be useful markers in follow-up of breast cancer and in prognosis. | 26408705 |
| Loss of Heterozygosity | Epigenetic Alterations | (iii) The relation of biallelic loss to miRNA expression was less clear but appeared to favor higher miRNA levels: of 60 miRNA-target gene pairs, 34 pairs (57%) had higher miRNA expression with biallelic loss than without, while 26 pairs (43%) had lower miRNA expression. | 26409826 |
| Multiple Myeloma | Epigenetic Alterations | Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma. | 26410378 |
| Multiple Myeloma, Gammopathy | Epigenetic Alterations | In multiple myeloma, a long non-coding RNA, KIAA0495 (alias PDAM/TP73-AS1), had been found progressively downregulated from normal plasma cell to benign monoclonal gammopathy of undetermined significance to symptomatic myeloma. | 26410378 |
| cervical cancer | Epigenetic Alterations | Multiple protein or microRNA markers have been recognized to contribute to the progression and recurrence of cervical cancers. | 26411419 |
| Carcinoma of lung | Epigenetic Alterations | DNA methylation age of blood predicts future onset of lung cancer in the womens health initiative. | 26411804 |
| Chronic sinusitis | Epigenetic Alterations | Differentially Expressed miRNA in Inflammatory Mucosa of Chronic Rhinosinusitis. | 26413631 |
| Craniosynostosis, Inflammation | Epigenetic Alterations | The RT-qPCR results indicate that the miRNAs were differentially expressed in CRS patients and various inflammation severities could lead to this difference. | 26413631 |
| Esophageal carcinoma | Epigenetic Alterations | MicroRNA-1 (mimics-miR-1) and its inhibitor (Inhibitor-miR-1) were transfected into esophageal cancer cells KYSE 510 and Eca 109; cell proliferation, migration, and invasion assays were carried out. | 26414725 |
| Primary malignant neoplasm | Epigenetic Alterations | The gene expression level of microRNA-1 in cancer tissues was significantly lower than that in adjacent normal tissues (P < 0.01). | 26414725 |
| Cerebrovascular accident | Epigenetic Alterations | MicroRNA let-7e Is a Potential Circulating Biomarker of Acute Stage Ischemic Stroke. | 26415639 |
| Breast Carcinoma | Epigenetic Alterations | Down-regulated microRNA-124 expression as predictive biomarker and its prognostic significance with clinicopathological features in breast cancer patients. | 26415857 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) have been documented as playing important roles in cancer development. | 26415857 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional regulators of gene expression and have shown promise as potential prognostic markers in several cancer types including BC. | 26416693 |
| Primary malignant neoplasm | Epigenetic Alterations | The miRNAs associated with OS identified in our cohort were validated using an external dataset from The Cancer Genome Atlas (TCGA) project. | 26416693 |
| Primary malignant neoplasm | Epigenetic Alterations | Among the known forms of miRNA packaging, tumour-derived exosome-enclosed miRNAs is thought to reflect the vital activity of cancer cells. | 26417675 |
| Prostate Cancer Pathway | Epigenetic Alterations | The assessment of the exosomal fraction of urinary miRNA may present a new and highly specific method for prostate cancer diagnostics; however, this is challenged by the absence of reliable and inexpensive methods for isolation of exosomes. | 26417675 |
| Prostate Cancer Pathway | Epigenetic Alterations | The miRNA profile of urinary exosomes reflects development of prostate cancer and may present a promising diagnostic tool. | 26417675 |
| Primary malignant neoplasm | Epigenetic Alterations | MiRNAs are small regulatory RNAs which play an important role in tumorogenesis and are being investigated as a cancer biomarker. | 26417675 |
| MIR21 gene, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Our data support a possible role of tumor epigenetic deregulation by noncoding RNA in suppressing the antitumor T-cell-mediated adaptive immune response and suggest MIR21 as a potential target for immunotherapy and prevention in colorectal cancer. | 26419959 |
| MIR21 gene, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA MIR21 and T Cells in Colorectal Cancer. | 26419959 |
| MIR21 gene | Epigenetic Alterations | Experimental evidence suggests that microRNA MIR21 (miR-21) suppresses antitumor T-cell-mediated immunity. | 26419959 |
| Clinical Coordinator, Carcinogenesis | Epigenetic Alterations | Histone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC. | 26423403 |
| Chronic Obstructive Airway Disease, Pulmonary Fibrosis, Primary malignant neoplasm | Epigenetic Alterations | Diagnostic Performance of Plasma DNA Methylation Profiles in Lung Cancer, Pulmonary Fibrosis and COPD. | 26425700 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation status as a biomarker of anti-epidermal growth factor receptor treatment for metastatic colorectal cancer. | 26426205 |
| Colorectal Cancer Pathway | Epigenetic Alterations | In conclusion, we found that the genome-wide DNA methylation status is a powerful epigenetic predictor of anti-EGFR treatment in patients with KRAS wild-type metastatic colorectal cancer (UMIN000005490). | 26426205 |
| Esophageal carcinoma | Epigenetic Alterations | In recent years, miRNA, a small RNA molecule, has drawn much attention to researchers as a potential biomarker for esophageal cancer. | 26427659 |
| Malignant Neoplasms | Epigenetic Alterations | miR-93 and miR-143 are two miRNA molecules reported to be frequently deregulated in various cancers, including prostate, stomach, cervix, and etc. | 26427659 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | These findings suggest that the deregulation of these miRNAs may play an important role in esophageal squamous cell carcinoma. | 26427659 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR). | 26427660 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia. | 26430723 |
| Malignant mesothelioma | Epigenetic Alterations | Combined circulating epigenetic markers to improve mesothelin performance in the diagnosis of malignant mesothelioma. | 26431916 |
| Liver carcinoma | Epigenetic Alterations | Long non-coding RNA CARLo-5 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. | 26433964 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, many studies show that long non-coding RNAs (lncRNAs) play important roles in cancer biology. | 26433964 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature. | 26436590 |
| Somatic mutation, Adult Burkitt Lymphoma | Epigenetic Alterations | Taken together, our results demonstrate a tight connection between somatic mutation, DNA methylation and transcriptional control in key B cell pathways deregulated differentially in Burkitt lymphoma and other germinal center B cell lymphomas. | 26437030 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miR) expression is commonly dysregulated in many cancers, including breast. | 26437339 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143. | 26439035 |
| Autoimmune state | Epigenetic Alterations | Long noncoding RNAs (lncRNA) play key roles in regulating autoimmunity and immunity balance. | 26440590 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-218 is a prognostic indicator in colorectal cancer and enhances 5-fluorouracil-induced apoptosis by targeting BIRC5. | 26442524 |
| Hematologic Neoplasms | Epigenetic Alterations | CC-486, the oral formulation of azacitidine (AZA), is an epigenetic modifier and DNA methyltransferase inhibitor in clinical development for treatment of hematologic malignancies. | 26442612 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate protein biosynthesis and participate in the pathogenesis of various tumours. | 26443314 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation, the best known epigenetic marker, can be used as a prognostic biomarker in many cancers. | 26443805 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | We examined DNA methylation status and survival in nasopharyngeal carcinoma (NPC) patients. | 26443805 |
| Breast Carcinoma | Epigenetic Alterations | CD24 expression was analyzed by immunohistochemistry in 747 breast cancer tissues, and DNA methylation and histone modification status in the promoter region of CD24 were assessed using bisulfite sequencing and chromatin immunoprecipitation assay. | 26444008 |
| Breast Carcinoma | Epigenetic Alterations | Furthermore, CD24 gene expression was associated with histone acetylation independent of DNA methylation, suggesting its epigenetic regulation in breast cancer. | 26444008 |
| Coronary Artery Disease | Epigenetic Alterations | Interaction between microRNA expression and classical risk factors in the risk of coronary heart disease. | 26446730 |
| Malignant tumor of colon | Epigenetic Alterations | Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications. | 26447334 |
| Liver carcinoma | Epigenetic Alterations | Circulating microRNA-200 Family as Diagnostic Marker in Hepatocellular Carcinoma. | 26447841 |
| Liver Cirrhosis, Hollings Cancer Center | Epigenetic Alterations | Circulating microRNA-200 family members are significantly deregulated in patients with HCC and liver cirrhosis. | 26447841 |
| Neoplasms | Epigenetic Alterations | The effect of epigenetic reversion in combination with chemotherapeutic drugs on apoptosis was also assessed according to the tumor p53 mutation status. | 26447864 |
| Primary malignant neoplasm | Epigenetic Alterations | On the other hand, in the KATO III cancer cell line (p53 mutant), epigenetic treatment alone induced robust apoptosis, with no trans-activation of p53. | 26447864 |
| Obesity | Epigenetic Alterations | Our results strongly suggest that many obesity-associated SNPs are associated with proximal gene regulation, which was reflected by association of obesity risk allele genotypes with differential DNA methylation. | 26449484 |
| Plaque (lesion), Carotid Stenosis | Epigenetic Alterations | miRNAs were measured in the plaque shoulder of carotid plaques obtained from patients undergoing carotid endarterectomy (CEA) for 3 distinct clinical scenarios: (1) patients without previous neurological events but high-grade carotid stenosis (asymptomatic), (2) patients with an acute neurological event within 5 days of the CEA (urgent), and (3) patients undergoing CEA>5 days after a neurological event (symptomatic). | 26451018 |
| Plaque, Atherosclerotic, Plaque (lesion) | Epigenetic Alterations | Atherosclerotic plaque rupture is accompanied by a loss of miR-221 and miR-222 and an increase in p27Kip1 mRNA expression in the plaque shoulder, suggesting an association between these miRNAs and atherosclerotic plaque stability. | 26451018 |
| Malignant tumor of colon, Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2. | 26452129 |
| Malignant tumor of colon | Epigenetic Alterations | Increasing evidence reveals that aberrant expression of microRNA contributes to the development and progression of colon cancer, but the roles of microRNA-506 (miR-506) in colon cancer remain elusive. | 26452129 |
| Primary Neoplasm, Malignant neoplasm of breast, Breast Carcinoma | Epigenetic Alterations | Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour. | 26452468 |
| Neoplasms | Epigenetic Alterations | Our results show that DNA methylation profiling as well as aCGH have potential as diagnostic tools in improving the clinical decisions to differentiate recurrences from a second de novo tumour. | 26452468 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | RARb Promoter Methylation as an Epigenetic Mechanism of Gene Silencing in Non-small Cell Lung Cancer. | 26453065 |
| Primary malignant neoplasm | Epigenetic Alterations | An increasing association between miRNA and cancer has been recently reported. | 26453197 |
| Vascular Invasion Assessment, Liver carcinoma | Epigenetic Alterations | Upregulation of MicroRNA-19b predicts good prognosis in patients with hepatocellular carcinoma presenting with vascular invasion or multifocal disease. | 26453548 |
| Hollings Cancer Center | Epigenetic Alterations | In both the miRNA microarray and real-time PCR, miR-19b was significantly overexpressed in the HCC tumor compared with adjacent non-tumor liver tissues (P < 0.001). | 26453548 |
| Degenerative polyarthritis | Epigenetic Alterations | Evidence suggests that epigenetics plays a role in osteoarthrits (OA). | 26453558 |
| Malignant Neoplasms, Neoplasms, Malignant tumor of colon | Epigenetic Alterations | DNA methylation variations in gene promoter regions are well documented tumor-specific alterations in human malignancies including colon cancer, which may influence tumor behavior and clinical outcome. | 26453961 |
| Malignant tumor of colon | Epigenetic Alterations | Here, we describe that DNA methylation levels at CpG loci of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil (5-FU) chemotherapy with respect to overall survival and progression-free survival. | 26453961 |
| Islet Cell Tumor | Epigenetic Alterations | Menin, the product of the Men1 gene, which is frequently mutated in pancreatic neuroendocrine tumors, acts as a chromatin-remodeling factor to modulate the transcription of cell cycle regulators by interacting with histone modification factors. | 26454216 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA profiles were generated from plasma samples of 5 patients with gastric cancer (GC) versus 5 healthy controls (HC). | 26456959 |
| Primary malignant neoplasm | Epigenetic Alterations | It was reported that circulating microRNAs could be applied as non-invasive biomarkers for cancer monitoring. | 26456959 |
| Primary Malignant Liver Neoplasm | Epigenetic Alterations | The Correlation Relationship between P14ARF Gene DNA Methylation and Primary Liver Cancer. | 26457819 |
| Primary Malignant Liver Neoplasm | Epigenetic Alterations | DNA methylation plays an important role in the process of primary liver cancer occurrence and development. | 26457819 |
| Primary Malignant Liver Neoplasm | Epigenetic Alterations | P14ARF mRNA level is regulated by DNA methylation in primary liver cancer. | 26457819 |
| Tetranitromethane, Primary Malignant Liver Neoplasm | Epigenetic Alterations | P14ARF gene DNA methylation may be associated with the occurrence of primary liver cancer occurrence and TNM staging. | 26457819 |
| Malignant Neoplasms | Epigenetic Alterations | Specific microRNA (miRNA) expression signatures have been identified in a variety of human cancers. | 26458593 |
| melanoma | Epigenetic Alterations | Loss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma. | 26462027 |
| melanoma | Epigenetic Alterations | That loss of the epigenetic biomarker, 5-hydroxymethylcytosine (5-hmC), is a hallmark for melanoma and correlates with virulence prompted us to explore the diagnostic utility and biological implications of 5-hmC immunohistochemistry (IHC) in melanomas with small cell/nevoid subpopulations. | 26462027 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | So we could say that epigenetic modification is a crucial mechanism for controlling the expression of miR-126 in glioma. | 26463235 |
| Glioma, Neoplasms | Epigenetic Alterations | Recently, several studies showed that the activation of the oncogenes and the inactivation and/or loss of the tumor suppressor genes, especially for miRNA-21, let-7 and so on, are the most primary molecule event in gliomas. | 26463235 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The expression level of miRNA-126 was found to be significantly higher in the control group (0.6134 +- 0.1214) than in the glioma group (0.2771 +- 0.1529; P < 0.05). | 26463235 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Our results indicate that we verified successfully the miRNA-126 down-regulation phenomenon in patients with glioma which showed in the results of glioma tissue miRNAs chip and the miRNA-126 down-regulation through methylation in patients with glioma. | 26463235 |
| Inflammatory Bowel Diseases | Epigenetic Alterations | Sparse Modeling Reveals miRNA Signatures for Diagnostics of Inflammatory Bowel Disease. | 26466382 |
| ibudilast | Epigenetic Alterations | These results suggest that the proposed miRNA signature is of relevance for the etiology of IBD. | 26466382 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | microRNA-622 acts as a tumor suppressor in hepatocellular carcinoma. | 26467022 |
| Neoplasms | Epigenetic Alterations | microRNAs (miRNAs) are important regulators of tumor development and progression. | 26467022 |
| Primary malignant neoplasm | Epigenetic Alterations | Moreover, we put forward the hypothesis that there are regulatory relationships between oncogenes and TSGs apart from the functional synergy of both; the oncogene-miRNA-TSG networks are one of mechanisms among the regulatory relationships; the regulatory relationships and the networks might play active roles in the development and progression of cancer. | 26467212 |
| Hollings Cancer Center | Epigenetic Alterations | Recently, numerous studies highlighted that microRNAs (miRNAs) were significantly differentially expressed in HCC tumorigenesis, and the expression was tissue-specific, indicating that miRNAs may cause great epigenetic changes in HCC tumorigenesis. | 26468017 |
| Hematologic Neoplasms | Epigenetic Alterations | Increasing evidences indicate that deregulation of microRNAs (miRNAs) might plays an important role in hematologic malignancies, including MPN. | 26468945 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Colorectal cancer (CRC) is a heterogeneous disease caused by genetic and epigenetic alterations. | 26471487 |
| Chronic Kidney Diseases | Epigenetic Alterations | Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise. | 26475583 |
| Chronic Kidney Diseases | Epigenetic Alterations | The differential expression in circulating miRNA in response to acute and chronic exercise may point toward a physiological role in cardiovascular adaptation to exercise, also in CKD. | 26475583 |
| TP53COR1 gene | Epigenetic Alterations | LincRNA-p21 is a long intergenic noncoding RNA, which is located on chromosome 17, approximately 15 kb upstream from the Cdkn1a (p21) gene. | 26475621 |
| Breast Carcinoma | Epigenetic Alterations | A circulating miRNA signature as a diagnostic biomarker for non-invasive early detection of breast cancer. | 26476723 |
| Breast Carcinoma | Epigenetic Alterations | We first conducted miRNA profiling of these 96 miRNAs by SdM-RT-PCR using the sera of 25 breast cancer patients at diagnosis prior to treatment and 20 age-matched healthy controls. | 26476723 |
| Breast Carcinoma | Epigenetic Alterations | A miRNA signature was validated in an independent set of 128 serum samples composed of 76 breast cancer patients and 52 healthy controls. | 26476723 |
| Breast Carcinoma | Epigenetic Alterations | Furthermore, the identified 3-miRNA signature is a promising circulating biomarker for breast cancer diagnosis. | 26476723 |
| Breast Carcinoma | Epigenetic Alterations | Circulating microRNAs (miRNAs) show potential for breast cancer detection, but the existing results appear to be mixed. | 26476723 |
| Breast Carcinoma | Epigenetic Alterations | Ninety-three miRNAs dysregulated or with functions in breast cancer were selected as candidates, and additional 3 miRNAs were chosen as endogenous controls. | 26476723 |
| Breast Carcinoma | Epigenetic Alterations | In the discovery stage, we identified 23 miRNAs as significantly dysregulated in breast cancer patients compared with healthy controls. | 26476723 |
| Breast Carcinoma | Epigenetic Alterations | Of these, 10 miRNAs were previously identified as dysregulated in breast cancer; 14 miRNAs remained significant after P-values were adjusted by both correction methods. | 26476723 |
| ovarian neoplasm | Epigenetic Alterations | The dysfunction of miRNA contributes to ovarian cancer development. | 26477861 |
| Cholangiocarcinoma, Choledochal Cyst | Epigenetic Alterations | Expression profile of microRNA-200 family in cholangiocarcinoma arising from choledochal cyst. | 26479153 |
| Malignant Neoplasms | Epigenetic Alterations | Epithelial-to-mesenchymal transition (EMT) is considered a critical step for various solid cancers, which is regulated by the microRNA-200 (miR-200) family. | 26479153 |
| Esophageal carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) have been associated with prognosis in esophageal cancer, suggesting a role for miRNAs to help guide treatment decisions. | 26481465 |
| Carcinoma of lung | Epigenetic Alterations | Accumulating evidence indicates that altered miRNA expression is crucially involved in lung cancer development, though scant information is available regarding how MYC, an archetypical oncogene, is regulated by miRNAs, especially via a mechanism involving MYC cofactors. | 26483346 |
| Squamous cell carcinoma of the head and neck, Neoplasms | Epigenetic Alterations | Tumor and normal epithelial tissues were obtained from 75 HNSCC patients to analyze selected miRNAs. | 26484611 |
| Adenoma of large intestine | Epigenetic Alterations | Gene-specific DNA methylation of DNMT3B and MTHFR and colorectal adenoma risk. | 26485042 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Polymorphisms in these genes have been implicated in colorectal cancer etiology; however, epigenetic modifications such as gene-specific DNA methylation also affect gene expression. | 26485042 |
| Adenoma of large intestine | Epigenetic Alterations | No association was observed between average DNA methylation of either DNMT3B or MTHFR and colorectal adenoma risk. | 26485042 |
| Adenoma of large intestine | Epigenetic Alterations | For DNMT3B, increasing DNA methylation of CpG sites in the gene-coding area was associated with a higher risk of colorectal adenomas (OR=1.34; 95% CI: 1.01-1.79 per SD). | 26485042 |
| ovarian neoplasm | Epigenetic Alterations | Of these, 10 miRNAs (miR-193a-5p, miR-375, miR-339-3p, miR-340-5p, miR-532-3p, miR-133a-3p, miR-25-3p, miR-10a-5p, miR-616-5p, and miR-148b-5p) displayed fold changes in concentration ranging from -2.9 to 4 (p<0.05), in recurrent platinum resistant ovarian cancer patients, that were associated with response to decitabine followed by carboplatin chemotherapy. | 26485143 |
| Prostate Cancer Pathway | Epigenetic Alterations | Identification of specific DNA methylation sites on the Y-chromosome as biomarker in prostate cancer. | 26485765 |
| Behcet Syndrome | Epigenetic Alterations | Global microRNA profiling of peripheral blood mononuclear cells in patients with Behcets disease. | 26486198 |
| F9 gene | Epigenetic Alterations | MicroRNA expressions can be linked to the development of LNM of PTC. | 26487287 |
| F9 gene | Epigenetic Alterations | We confirmed already described up-regulations of microRNAs in PTC, such as miR-146b-5p or miR-222-3p, but we also identified down-regulated microRNAs, such as miR-7-5p or miR-30c-2-3p. | 26487287 |
| F9 gene | Epigenetic Alterations | In addition, 12 of the 14 down-regulated microRNAs are significantly less expressed in aggressive PTC compared to non-aggressive PTC. | 26487287 |
| Malignant Neoplasms, Colorectal Cancer Pathway, Clinical Coordinator | Epigenetic Alterations | Mounting evidence indicates that one specific miRNA: miR-320b is down regulated in numerous human cancers, including colorectal cancer (CRC); making the hypothesis that miR-320b may play a key role in tumorigenesis plausible. | 26487644 |
| Hepatitis, Liver carcinoma | Epigenetic Alterations | Hepatic DNA Methylation Is Affected by Hepatocellular Carcinoma Risk in Patients with and without Hepatitis Virus. | 26489010 |
| Hollings Cancer Center | Epigenetic Alterations | Here, we identified HCC risk factors that are associated with DNA methylation in the background liver tissue of NBNC-HCC patients. | 26489010 |
| Hollings Cancer Center | Epigenetic Alterations | On the other hand, epigenetic alterations are reportedly responsible for HCC development. | 26489010 |
| Malignant neoplasm of breast | Epigenetic Alterations | The BRCA1 gene plays a key role in triple negative breast cancers (TNBCs), in which its expression can be lost by multiple mechanisms: germinal mutation followed by deletion of the second allele; negative regulation by promoter methylation; or miRNA-mediated silencing. | 26490435 |
| Malignant neoplasm of breast | Epigenetic Alterations | Evaluation of BRCA1-related molecular features and microRNAs as prognostic factors for triple negative breast cancers. | 26490435 |
| Neoplasms | Epigenetic Alterations | Maintenance of expressed BRCA1 protein interaction with BARD1 was quantified, as a marker of BRCA1 functionality, and the tumor expression profiles of 27 microRNAs were determined. | 26490435 |
| Mucoepidermoid carcinoma of salivary gland | Epigenetic Alterations | Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration. | 26490796 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs have been proposed as significant regulators of carcinogenesis, and several of them have been demonstrated to have direct roles in survival of CSLCs. | 26490990 |
| Glioma, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Taken together, DNA-based large-scale molecular profiling indicates that GC comprises a genetically and epigenetically heterogeneous group of diffuse gliomas that carry DNA methylation and copy number profiles closely matching the common molecularly defined glioma entities. | 26493382 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-200c as a Prognostic Biomarker for Pancreatic Cancer. | 26493507 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | In cancer biology, miRNA affects the growth and metastasis of cancer cells by controlling epithelial-mesenchymal transition (EMT). | 26493507 |
| Carcinoma of lung | Epigenetic Alterations | As chip-digital PCR becomes more established, it would be a robust tool for quantitative assessment of miRNA copy number for diagnosis of lung cancer and other diseases. | 26493562 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are a new promising class of circulating biomarkers for cancer detection, but lack of consensus on data normalization methods has affected the diagnostic potential of circulating miRNAs. | 26493562 |
| Traumatic injury | Epigenetic Alterations | Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma. | 26496100 |
| Antilymphocyte Serum | Epigenetic Alterations | Many of the genes associated with genetic ALS have pathological biological pathways related to RNA metabolism, and their pathogenesis may be affecting the maturing processes of miRNA. | 26497046 |
| Cartilage injury | Epigenetic Alterations | Three novel miRNAs were regulated across models of chondrogenesis, chondrocyte differentiation or cartilage injury. | 26497608 |
| ovarian neoplasm | Epigenetic Alterations | HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. | 26497652 |
| ovarian neoplasm | Epigenetic Alterations | We analyzed HOTAIR expression and associated surrogate DNA methylation (DNAme) in 134 primary ovarian cancer cases (63 received carboplatin, 55 received cisplatin and 16 no chemotherapy). | 26497652 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA expression profiling identifies miR-31-5p/3p as associated with time to progression in wild-type RAS metastatic colorectal cancer treated with cetuximab. | 26497852 |
| Purpura, Thrombotic Thrombocytopenic | Epigenetic Alterations | MiRNAs expression profiling was performed on the exploratory cohort of 41 wt-KRAS mCRC patients treated with cetuximab to identify miRNAs associated with time to progression (TTP). | 26497852 |
| Esophageal carcinoma | Epigenetic Alterations | Five miRNAs Considered as Molecular Targets for Predicting Esophageal Cancer. | 26498375 |
| Cardiac dysfunction | Epigenetic Alterations | Recently, it has been recognized that changes in microribonucleic acid (miRNA) expression may lead to cardiac dysfunction. | 26498537 |
| Neoplasms | Epigenetic Alterations | Accumulating data suggested that hsa-microRNAs (miRNAs) could be potential biomarkers for tumor diagnosis due to their important roles in the cell cycle. | 26499781 |
| CHOANAL ATRESIA, POSTERIOR, Neoplasms | Epigenetic Alterations | The average relative expressions of hsa-miR-203 and hsa-miR-30c in tumor tissues were significantly different from those in adjacent normal tissues (P < 0.001), and the predictive power of the two hsa-miRNAs for PCa prognosis was reliable. | 26499781 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-613 (miR-613) plays important roles in tumorigenesis and cancer progression. | 26499784 |
| Neoplasms | Epigenetic Alterations | However, expression instability of reference genes in tumors may introduce bias when determining miRNA levels. | 26499892 |
| Pancreatic carcinoma | Epigenetic Alterations | Small nucleolar RNA U91 is a new internal control for accurate microRNAs quantification in pancreatic cancer. | 26499892 |
| ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | RT-qPCR quantification of miRNAs expression may play an essential role in pancreatic ductal adenocarcinoma (PDAC) diagnostics. | 26499892 |
| Neoplasms | Epigenetic Alterations | Thus, statistically significant and insignificant differences between tumors and normal tissues for miRNAs were equal for the spike and the U91. | 26499892 |
| Neoplasms | Epigenetic Alterations | The microRNA miR-19a is overexpressed in many solid tumours and regulates the suppressor of cytokine signalling-1 (SOCS-1) expression. | 26502748 |
| intracranial glioma | Epigenetic Alterations | The expression of microRNA-449a in brain tissue or peripheral blood of patients with brain glioma was significantly lower than that of normal people, and the differences were statistically significant (p < 0.05). | 26502848 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Upon interfering with microRNA-449a, the glioma cell proliferation was significantly increased while apoptosis was significantly reduced, the PKCa protein levels were increased significantly and the differences were statistically significant (all p < 0.05); after overexpression of microRNA-449a, the glioma cell proliferation was significantly decreased while the cell apoptosis was significantly increased, the PKCa protein levels were decreased significantly and the differences were statistically significant (all p < 0.05). | 26502848 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The expression of microRNA-449a is low in patients with glioma, which may inhibit the proliferation of glioma and promote its cell apoptosis via affecting the expression of PKCa. | 26502848 |
| ovarian neoplasm | Epigenetic Alterations | Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway. | 26503132 |
| Hepatitis C | Epigenetic Alterations | Miravirsen dosing in chronic hepatitis C patients results in decreased microRNA-122 levels without affecting other microRNAs in plasma. | 26503793 |
| Hepatitis C | Epigenetic Alterations | MicroRNA-122 (miR-122) is an important host factor for hepatitis C virus replication. | 26503793 |
| Islet Cell Tumor | Epigenetic Alterations | Endoplasmic Reticulum Stress in Pancreatic Neuroendocrine Tumors is Linked to Clinicopathological Parameters and Possible Epigenetic Regulations. | 26504039 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | Methylation-associated Silencing of microRNA-126 and its Host Gene EGFL7 in Malignant Pleural Mesothelioma. | 26504055 |
| 1-methyl-1-piperidinomethane sulfonate, Malignant Pleural Mesothelioma | Epigenetic Alterations | We recently reported that miR-126 is down-regulated in malignant pleural mesothelioma (MPM) and can be combined into a 4-microRNA-classifier that can accurately diagnose MPM with high sensitivity and specificity. | 26504055 |
| Malignant Neoplasms, Malignant neoplasm of endometrium, Carcinogenesis | Epigenetic Alterations | Endometrial cancer is the most common malignancy of the female genital tract while aberrant DNA methylation seems to play a critical role in endometrial carcinogenesis. | 26504828 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer. | 26505339 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | In summary, our results suggest that the DNA methylation levels of EGFR can be used as an important indicator for the stage of cancer tissue malignancy. | 26505339 |
| Pancreatic carcinoma | Epigenetic Alterations | Plasma microRNA profiles: identification of miR-744 as a novel diagnostic and prognostic biomarker in pancreatic cancer. | 26505678 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. | 26506418 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | We determined expression of 83 long non-coding RNAs (lncRNAs) and identified ZFAS1 to be significantly up-regulated in colorectal cancer (CRC) tissue. | 26506418 |
| SF3B1 wt Allele | Epigenetic Alterations | These data suggest that mutations in epigenetic modification and splicesome genes are common in Chinese patients with MDS, while mutations in U2AF1 and SRSF2 appear to predict an unfavorable prognosis. | 26508027 |
| Hollings Cancer Center | Epigenetic Alterations | Serum and tissue microRNA levels were compared in 14 patients surgically treated for HCC. | 26509672 |
| Cirrhotic, Hollings Cancer Center | Epigenetic Alterations | Circulating microRNAs, miR-939, miR-595, miR-519d and miR-494, Identify Cirrhotic Patients with HCC. | 26509672 |
| Hollings Cancer Center | Epigenetic Alterations | Therefore, we show that circulating microRNAs deserve attention as non-invasive biomarkers in the diagnostic setting of HCC and that exosomal secretion contributes to discharging a subset of microRNAs into the extracellular compartment. | 26509672 |
| Prostate Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. | 26509963 |
| CHOANAL ATRESIA, POSTERIOR, Metastasis | Epigenetic Alterations | Elucidation of the molecular pathways modulated by tumor-suppressive miRNAs provides insights into the mechanisms of PCa progression and metastasis. | 26509963 |
| Colorectal Neoplasms | Epigenetic Alterations | Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway. | 26510091 |
| Clinical Coordinator, Colorectal Cancer Pathway, Sessile Serrated Adenoma/Polyp, Traditional Serrated Adenoma | Epigenetic Alterations | To clarify molecular alterations in serrated pathway of colorectal cancer (CRC), we performed epigenetic and genetic analyses in sessile serrated adenoma/polyps (SSA/P), traditional serrated adenomas (TSAs) and high-methylation CRC. | 26510091 |
| Breast Carcinoma | Epigenetic Alterations | Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation. | 26510686 |
| Breast Carcinoma | Epigenetic Alterations | Breast cancer formation is associated with frequent changes in DNA methylation but the extent of very early alterations in DNA methylation and the biological significance of cancer-associated epigenetic changes need further elucidation. | 26510686 |
| Primary malignant neoplasm | Epigenetic Alterations | In addition, examination of transcriptome and DNA methylation databases indicated that methylation at three non-promoter regions (far-upstream EN1 and PITX2 and intronic LHX2) was associated with higher gene expression, unlike the inverse associations between cancer DNA hypermethylation and cancer-altered gene expression usually reported. | 26510686 |
| Breast Carcinoma | Epigenetic Alterations | We confirmed the frequent DNA methylation changes in invasive breast cancer at a variety of genome locations and found evidence for an extensive field effect in breast cancer. | 26510686 |
| Primary malignant neoplasm | Epigenetic Alterations | In addition, we illustrate the power of combining publicly available whole-genome databases with a candidate gene approach to study cancer epigenetics. | 26510686 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Epigenetic silencing of HIC1 promotes epithelial-mesenchymal transition and drives progression in esophageal squamous cell carcinoma. | 26510908 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Together, loss of the regulation of EphA2 pathway through HIC1 epigenetic silencing could be an important mechanism in the ESCC progression. | 26510908 |
| palladium | Epigenetic Alterations | It identifies changes in crucial components of chromatin remodeling and methylation machineries as early events in sporadic PD suggesting epigenetics as target for therapeutic intervention. | 26510930 |
| Neoplasms | Epigenetic Alterations | Our aim was to determine if the distributions of clinicopathologic factors in CIMP-positive tumors with MLH1 DNA methylation differed from those in CIMP-positive tumors without DNA methylation of MLH1. | 26512054 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-206 functions as a tumor suppressor in colorectal cancer by targeting FMNL2. | 26515696 |
| Clinical Coordinator | Epigenetic Alterations | MicroRNAs play important roles in the progression of CRC. | 26515696 |
| Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | We hypothesize that miR-3151, localized to a GWAS-identified chronic lymphocytic leukemia (CLL) risk locus (8q22.3), is a tumor suppressor miRNA silenced by promoter DNA methylation in CLL. | 26517243 |
| ETFA gene, Chronic Lymphocytic Leukemia | Epigenetic Alterations | miR-3151 silencing by DNA methylation protected CLL cells from apoptosis through over-expression of its direct targets MADD and PIK3R2, hence constitutive activation of MEK/ERK and PI3K/AKT signaling respectively, and consequently over-expression of MCL1. | 26517243 |
| Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways. | 26517243 |
| Primary malignant neoplasm | Epigenetic Alterations | Various miRNAs have recently emerged as potential prognostic biomarkers in cancer. | 26517683 |
| Neoplasms | Epigenetic Alterations | Furthermore, we show that the expression of these miRNAs is decreased in high grade and stage tumors, and the down-regulation is associated with patients poor clinical outcome. | 26517683 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells. | 26517688 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Recent studies show that long non-coding RNAs (lncRNAs) may be significant functional regulators in tumor development, including bladder cancer. | 26517688 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer. | 26518883 |
| Neoplasms | Epigenetic Alterations | Because epigenetic silencing is the hallmark of a tumor suppressor we tested eta in focus formation assays and found that it is capable of suppressing ras-induced transformation of NIH3T3 cells. | 26518883 |
| Inflammatory disorder | Epigenetic Alterations | MicroRNAs (miRNAs) are short non-coding RNAs whose expression profiles can serve as diagnostic biomarkers and which may be involved in the pathophysiology of neuroinflammatory diseases. | 26521232 |
| Neuromyelitis Optica, MS gene | Epigenetic Alterations | Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis. | 26521232 |
| Degenerative polyarthritis | Epigenetic Alterations | Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis. | 26521741 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | DNA methylation changes are a constant feature of acute myeloid leukemia. | 26522083 |
| Primary malignant neoplasm | Epigenetic Alterations | Global DNA hypomethylation at the 5 position of cytosine (5mC) is a well-known epigenetic feature of cancer. | 26525607 |
| Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | MiRNAs have been shown to be aberrantly expressed in CN-AML. | 26526573 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Release kinetics of circulating miRNA-208a in the early phase of myocardial infarction. | 26528525 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | These results demonstrate that plasma miRNA-208a is an interesting and promising candidate for a new biomarker released early after onset of myocardial infarction. | 26528525 |
| Tissue injury | Epigenetic Alterations | Recent scientific results suggested that microRNAs (miRNAs) might become a new biomarker of tissue injury. | 26528525 |
| Malignant Neoplasms, Viral hepatitis, Liver Cirrhosis, Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Association between microRNA-196A2 and microRNA-146A polymorphisms and progression to cirrhosis and hepatocellular carcinoma in patients with viral hepatitis B. MicroRNAs (miRNAs) are small noncoding RNAs that have been implicated in mechanisms underlying various types of cancers including hepatocellular carcinoma (HCC). | 26529280 |
| Communicable Diseases, Hepatitis B, Liver Cirrhosis, Hollings Cancer Center | Epigenetic Alterations | Reports have indicated that single nucleotide polymorphisms in miRNA-196A2 and miRNA-146A genes may contribute to the risk of progression of hepatitis B virus (HBV) infection to cirrhosis and HCC. | 26529280 |
| Hollings Cancer Center | Epigenetic Alterations | Our results showed that serum levels of three microRNAs (miRNAs) were significantly decreased in HCC cases than those in benign and healthy controls (all P < 0.05). | 26531720 |
| Metastasis, Hollings Cancer Center | Epigenetic Alterations | Also, dynamic monitoring three miRNAs can help us predict recurrence or metastasis in HCC cases after surgical resection. | 26531720 |
| Congenital contractural arachnodactyly | Epigenetic Alterations | Several microRNAs (miRNAs) have been reported to be dysregulated in CCA tissues. | 26534789 |
| MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME | Epigenetic Alterations | MicroRNA expression profile of a Malaysian Bajau family with familial mitochondrial neurogastrointestinal encephalomyopathy. | 26535630 |
| TYMP wt Allele | Epigenetic Alterations | In conclusion, we demonstrate that blood miRNAs are deregulated in the pathogenesis of MNGIE and these changes may have therapeutic implications. | 26535630 |
| Metastasis | Epigenetic Alterations | Further, we identified 83 genes that are associated with lymph node metastasis and correlated these with miRNA-expression. | 26537449 |
| Calcification of coronary artery | Epigenetic Alterations | Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients. | 26537670 |
| caffeine/cisplatin/cytarabine protocol | Epigenetic Alterations | Eight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort. | 26537670 |
| caffeine/cisplatin/cytarabine protocol | Epigenetic Alterations | Four miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC. | 26537670 |
| Lung Diseases, Obstructive, caffeine/cisplatin/cytarabine protocol | Epigenetic Alterations | We identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients. | 26537670 |
| Cardiovascular Diseases | Epigenetic Alterations | MicroRNAs (miRNAs) can contribute to the development of cardiovascular diseases, and single nucleotide polymorphisms (SNPs) in miRNA genes may influence disease susceptibility by altering mature miRNA expression levels. | 26537765 |
| Primary malignant neoplasm | Epigenetic Alterations | Our findings that epigenetic effects of cancer metabolic reprogramming may promote DNA repair provide a molecular mechanism by which deregulation of metabolism may not only support cell growth but also maintain cell immortality, drive therapeutic resistance, and promote genomic instability. | 26538285 |
| Primary malignant neoplasm | Epigenetic Alterations | By defining a pathway from deregulated metabolism to enhanced DNA damage response in cancer, these data provide a rationale for targeting downstream epigenetic effects of metabolic reprogramming to block cancer cell immortality and overcome resistance to genotoxic stress. | 26538285 |
| Stomach Carcinoma | Epigenetic Alterations | LINC00152 was documented as an important long non-coding RNA (lncRNA) involved in the pathogenesis of gastric cancer; however, the detailed mechanism of action of LINC00152 remains unknown. | 26540343 |
| Malignant neoplasm of liver, Neoplasms | Epigenetic Alterations | Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1). | 26540633 |
| Malignant neoplasm of liver | Epigenetic Alterations | Highly up-regulated in liver cancer (HULC) is a long non-coding RNA (lncRNA). | 26540633 |
| cervical cancer | Epigenetic Alterations | Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer. | 26542757 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | We identified 11 prognostic mRNA/miRNA predictors associated with the overall survival of COAD patients, suggesting the correlation of STIM1-associated features to clinicopathological outcomes. | 26543234 |
| Malignant Neoplasms | Epigenetic Alterations | Altered salivary micro-RNA (miRNA) expression levels have been observed in saliva from patients with various cancers. | 26544193 |
| Parotid Neoplasms | Epigenetic Alterations | A two miRNA combination can predict the presence of a parotid gland neoplasm. | 26544193 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Long non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway. | 26544536 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Long non-coding RNA urothelial cancer-associated 1 (lncRNA-UCA1) is highly expressed in bladder cancer tissues and cells, and it has been shown to play an important role in regulating aggressive phenotypes of bladder cancer cells. | 26544536 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Numerous studies suggest that several long non-coding RNAs (lncRNAs) play critical roles in bladder cancer development and progression. | 26544536 |
| Primary malignant neoplasm | Epigenetic Alterations | Examination of The Cancer Genome Atlas (TCGA) project miRNA data on 305 OSCCs and 30 controls revealed 100% of those miRNAs enriched in never smoker OSCCs in this patient group were also enriched in ever smoker OSCCs. | 26544609 |
| Neoplasms | Epigenetic Alterations | Nonsupervised clustering of TCGA OSCCs was suggestive of two or four subgroups of tumors based on miRNA levels with limited evidence for differences in tobacco exposure among the groups. | 26544609 |
| Malignant Neoplasms | Epigenetic Alterations | Results from both patient groups together stress the importance of miR196a-5p in OSCC malignancy in both never and ever smokers, and emphasize the overall similarity of miRNA expression in OSCCs in these two risk groups. | 26544609 |
| Hypodiploid B Acute Lymphoblastic Leukemia | Epigenetic Alterations | Genetic and epigenetic characterization of hypodiploid acute lymphoblastic leukemia. | 26544893 |
| Initiation, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs, miRs) are small, non-coding RNAs that are likely to play significant roles in cancer initiation and progression where they may act as oncogenes or tumor suppressors. | 26545583 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer. | 26545583 |
| Malignant Neoplasms, Hematologic Neoplasms | Epigenetic Alterations | Cytoplasmic polyadenylation element binding protein 4 (CPEB4) is a regulator of gene transcription and has been reported to be associated with biological malignancy in cancers. | 26546435 |
| Neoplasms | Epigenetic Alterations | DNA methylation in the promoter regions is considered to be a mechanism through which tumor suppressor genes are inhibited, which will lead to tumorigenesis and tumor progression. | 26547439 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma. | 26547929 |
| Malignant Neoplasms, Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | MicroRNA-9 (miR-9) dysregulation is implicated in a variety of human malignancies including hepatocellular carcinoma (HCC), but its role remains contradictory. | 26547929 |
| Stomach Carcinoma | Epigenetic Alterations | PRL-3 regulates microRNA in gastric cancer. | 26548949 |
| Granuloma, Radicular Cyst | Epigenetic Alterations | The purpose of the present investigation was to analyze the expression of MMP2 and MMP9 in periapical granulomas and radicular cysts and to test the hypothesis that, in these lesions, their transcription may be modulated by DNA methylation. | 26549219 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNAs play important roles in regulation of the initiation and progression of AML. | 26549593 |
| Behavior | Epigenetic Alterations | Recent studies suggest that microRNAs (miRNAs) can regulate the evolution of malignant behavior by regulating multiple target genes. | 26549725 |
| Prostate Cancer Pathway | Epigenetic Alterations | Epigenetic silencing of the mentioned genes could be novel molecular markers for the prognosis of advanced prostate cancer. | 26551297 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Expression of long noncoding RNA lncRNA-n336928 is correlated with tumor stage and grade and overall survival in bladder cancer. | 26551459 |
| Alzheimers Disease | Epigenetic Alterations | Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimers disease. | 26553823 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | We have previously reported in Alzheimers disease (AD) the mislocalization of epigenetic molecules between the cell nucleus and the cytoplasm. | 26553823 |
| Admitting diagnosis | Epigenetic Alterations | Because of the known role of H3k4me3 in the expression of synaptic genes, our data suggest an epigenetic role in synaptic deficits early in the course of AD. | 26553823 |
| Liver carcinoma | Epigenetic Alterations | Downregulation of MicroRNA-1 is Associated with Poor Prognosis in Hepatocellular Carcinoma. | 26554254 |
| Osteoporosis | Epigenetic Alterations | MicroRNAs (miRNAs) are important regulators of gene expression, with documented roles in bone metabolism and osteoporosis, suggesting potential therapeutic targets. | 26555194 |
| Breast Carcinoma, Psychobiology | Epigenetic Alterations | Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer. | 26555546 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Although aberrant DNA methylation has been described in rheumatoid arthritis (RA), no studies have interrogated this epigenetic modification in early disease. | 26556652 |
| Right arm | Epigenetic Alterations | Following recent investigations of T and B lymphocytes in established disease, we now characterize in these cell populations genome-wide DNA methylation in treatment-naive patients with early RA. | 26556652 |
| Right arm | Epigenetic Alterations | Treatment-naive early RA patients display novel disease-specific DNA methylation aberrations, supporting a potential role for these changes in the development of RA. | 26556652 |
| Angina Pectoris, Aortic Valve Stenosis | Epigenetic Alterations | Serum (S) and PF from patients undergoing coronary artery bypass graft (CABG) due to stable angina pectoris (sAP) and unstable AP (uAP) and aortic valve replacement due to aortic stenosis (AS) were analyzed for the detection of miRNAs. | 26562412 |
| Diabetic Nephropathy | Epigenetic Alterations | Rs12976445 Polymorphism is Associated with Risk of Diabetic Nephropathy Through Modulating Expression of MicroRNA-125 and Interleukin-6R. | 26563755 |
| Breast Carcinoma | Epigenetic Alterations | None of the 13 serum proteins nor miRNA 135b identified women with HRN or TN breast cancer. | 26565788 |
| Neoplasms | Epigenetic Alterations | Ninety-eight patients with tumor specimens from 2 timepoints were measured for DNA methylation in the promoter regions across 4 genes. | 26566081 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA profiling in serum and tissue samples to assess noninvasive biomarkers for NSCLC clinical outcome. | 26566629 |
| Non-Small Cell Lung Carcinoma, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | In NSCLC, the altered expression of some miRNAs in primary tumor tissues has been correlated with diagnosis and prognosis, while the role of circulating miRNAs as cancer biomarkers is currently emerging. | 26566629 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These data suggest the possibility to monitor affected patients through serum and/or tissue samples, analyzing the altered expression of specific miRNAs, in order to detect prognostic biomarkers in the NSCLC. | 26566629 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | The DNA methylation regulator TET2 is frequently mutated in AML, and we hypothesized that studying TET2-specific differentially methylated CpGs (tet2-DMCs) improves AML classification. | 26568194 |
| Primary malignant neoplasm | Epigenetic Alterations | In The Cancer Genome Atlas (TCGA) dataset where DNA methylation was analyzed by a different platform, tet2-DMC-low methylation was also associated with improved outcome (median survival = 55 vs 15 months, P = .0003) and was a better predictor of survival than mutations in TET2, IDH1, or IDH2, individually or combined. | 26568194 |
| Ulcerative Colitis | Epigenetic Alterations | Site-Specific MicroRNA Expression May Lead to Different Subtypes in Ulcerative Colitis. | 26569605 |
| Inflammation, Primary malignant neoplasm | Epigenetic Alterations | MiRNA are reported as a connecting link between inflammation and cancer. | 26569605 |
| Crohn Disease | Epigenetic Alterations | Differential miRNA expression is reported in Crohns disease (CD) patients involving various regions of the gastrointestinal tract. | 26569605 |
| Clinical Coordinator, Ulcerative Colitis | Epigenetic Alterations | Taking our data and previous reports into consideration, we propose that differential miRNA expression during UC perhaps contribute in the development of UC-associated CRC at the rectosigmoid area. | 26569605 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer. | 26572146 |
| Malignant neoplasm of kidney | Epigenetic Alterations | MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9. | 26573018 |
| Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction. | 26573378 |
| Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA (miR)-1246 is involved in differentiation, invasion, metastasis and chemoresistance of certain types of tumor cells. | 26573378 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In particular, the miRNA let-7 has been suggested to regulate the expression of the KRAS gene, a common mutated gene in non-small cell lung cancer (NSCLC), through a let-7 complementary site (LCS) in 3UTR of KRAS mRNA. | 26573509 |
| cervical cancer | Epigenetic Alterations | Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21. | 26574780 |
| Malignant Neoplasms | Epigenetic Alterations | Recent research has found that long noncoding RNAs (lncRNAs) were involved in various human cancers. | 26574780 |
| Metastasis, Neoplasms, HPV-High Risk, cervical cancer, Federation of Gynecology and Obstetrics | Epigenetic Alterations | We observed that MEG3 was downregulated in cervical cancer tissues, compared to the adjacent normal tissues, and was negatively related with FIGO stages, tumor size, lymphatic metastasis, HR-HPV infection and the expression of homo sapiens microRNA-21 (miR-21). | 26574780 |
| Autoimmune hepatitis | Epigenetic Alterations | Circulating microRNA Profiles in Patients with Type-1 Autoimmune Hepatitis. | 26575387 |
| Insemination, Artificial, Homologous | Epigenetic Alterations | We postulate that aberrantly expressed serum miRNAs are potential biomarkers of AIH and could be implicated in AIH pathogenesis. | 26575387 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is a frequent and early epigenetic event with potential application as a biomarker for cancer detection and an indicator of disease evolution. | 26575865 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | The reversibility of DNA methylation was examined by 5-Aza-CdR treatment in human bladder cancer cell lines. | 26575865 |
| Stomach Carcinoma | Epigenetic Alterations | The expression patterns of miR-27b-3p and ROR1 in human gastric cancer (GC) specimens and cell lines were determined by microRNA RT-PCR and western blotting. | 26576539 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | MicroRNA molecular profiling from matched tumor and bio-fluids in bladder cancer. | 26576778 |
| Neoplasms | Epigenetic Alterations | Significant associations were noted between the log-adjusted average miRNA counts in tumor vs. WBCs (r = 0.418 p < 0.001), and tumor vs. urine (r = 0.38 p < 0.001). | 26576778 |
| Malignant Neoplasms, Breast Carcinoma, Metastasis, Neoplasms | Epigenetic Alterations | Hox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is pervasively overexpressed and correlated with tumor invasion, progression, metastasis, and poor prognosis in various human cancers including breast cancer (BC) that plays a role as an oncogenic molecule. | 26577852 |
| Esophageal carcinoma | Epigenetic Alterations | Treatment of esophageal cancer cells with demethylating agent 5-Aza-dC led to increased miR-203a and miR-203b expression, confirming the epigenetic regulation of both miRNAs. | 26577858 |
| Esophageal carcinoma, Neoplasms | Epigenetic Alterations | The inhibition of proliferation and invasiveness in esophageal cancer cells after treated with 5-Aza-dC or transfected with miR-203a or miR-203b mimics, suggesting the tumor suppressor role of both miRNAs in esophageal cancer. | 26577858 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | In summary, our results suggest that miR-203a and miR-203b may function as tumor-suppressive miRNAs that are inactivated through proximal promoter hypermethylation and miR-203a expression and methylation may be useful prognostic marker in ESCC patients. | 26577858 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-Related DNA Repair/Cell-Cycle Genes Independently Associated With Relapse After Radiation Therapy for Early Breast Cancer. | 26581147 |
| Breast Carcinoma | Epigenetic Alterations | We had previously identified microRNA-139-5p and microRNA-1274a as key regulators of breast cancer radiation response in vitro. | 26581147 |
| Breast Carcinoma | Epigenetic Alterations | Additionally, independent publicly available mRNA/microRNA microarray expression datasets totaling >1000 early-stage breast cancer patients, treated with adjuvant radiation therapy, with >10 years of follow-up, were analyzed. | 26581147 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Long noncoding RNA (lncRNA) NEAT1 has been reported to play critical roles in various human tumor entities and related to the survival of patients with malignancies. | 26582084 |
| Intervertebral disc disorder | Epigenetic Alterations | Accumulating evidence suggests that miRNAs play an important role in IDD, but the role of specific miRNAs involved in this disease remains elusive. | 26583473 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-148a Suppresses Invasion and Metastasis of Human Non-Small-Cell Lung Cancer. | 26584284 |
| Carcinogenesis, Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Growing evidence indicates that miRNAs are involved in carcinogenesis and tumor progression in non-small-cell lung cancer (NSCLC). | 26584284 |
| Barrett Esophagus | Epigenetic Alterations | Profiling of circulating microRNAs in patients with Barretts esophagus and esophageal adenocarcinoma. | 26585599 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | IDH1 mutated paralimbic glioma shared many parameters with the purely insular glioma in respect to growth patterns, survival, and microRNA profile, but differed significantly from the IDH1 wild type paralimbic gliomas. | 26586262 |
| Agenesis of corpus callosum | Epigenetic Alterations | A comprehensive analysis of the different possible genetic and epigenetic mechanisms leading to TP53 alteration in ACC has never been reported and hence the role of TP53 in the pathogenesis and/or progression of ACC remains unclear. | 26586531 |
| Intervertebral disc disorder, Intervertebral Disc Degeneration | Epigenetic Alterations | Intervertebral disc degeneration (IDD) is associated with dysregulated expression of microRNAs (miRNAs). | 26587789 |
| Intervertebral disc disorder | Epigenetic Alterations | Therefore, we tested the hypothesis that miRNAs modulate IDD through effects on the IL-6/STAT3 signaling pathway, a potential regulator of IDD. | 26587789 |
| Neoplasms, Neoplasm Metastasis | Epigenetic Alterations | The tumor suppressor p53 and the transcriptional repressor Enhancer of Zeste Homolog 2 (EZH2) have both been implicated in the regulation of epithelial-mesenchymal transition (EMT) and tumor metastasis via their impacts on microRNA expression. | 26587974 |
| muscle cell differentiation, Antilymphocyte Serum, Atrophic | Epigenetic Alterations | Circulating microRNAs as biomarkers of muscle differentiation and atrophy in ALS. | 26588026 |
| Carcinoma | Epigenetic Alterations | miRNA expression profiles were compared between carcinoma cells, stromal cells and normal tissue samples. | 26590090 |
| Carcinoma | Epigenetic Alterations | A total of 43 miRNAs were found to be differentially expressed between carcinoma and stroma of which 11 belong to three miRNA families (miR-17, miR-15 and miR-515). | 26590090 |
| Carcinoma | Epigenetic Alterations | The miRNA-mRNA mediated interactions between carcinoma and stromal cells add new knowledge regarding tumor-stroma interactions. | 26590090 |
| Adenocarcinoma | Epigenetic Alterations | Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma. | 26590090 |
| Periampullary carcinoma | Epigenetic Alterations | Whereas miRNAs are known to regulate various cellular processes and interactions between cells, their exact role in periampullary carcinoma remains to be characterized, especially with respect to the prominent stromal component of pancreatobiliary type cancers. | 26590090 |
| Pituitary Adenoma | Epigenetic Alterations | Our results further support that epigenetic events are involved in the pathogenesis and biology of pituitary adenomas (PA). | 26593398 |
| Neoplasms | Epigenetic Alterations | MicroRNAs have been integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. | 26595523 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA-203 Is a Prognostic Indicator in Bladder Cancer and Enhances Chemosensitivity to Cisplatin via Apoptosis by Targeting Bcl-w and Survivin. | 26599571 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis. | 26601720 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells. | 26601720 |
| Carcinoma of lung, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Lung cancer patients have in general a poor prognosis, and a deeper insight into the epigenetic landscape in lung adenocarcinoma tumors and its prognostic implications is needed. | 26601720 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Neoplasms | Epigenetic Alterations | Increasing evidence suggests that epigenetic regulation is responsible for tumor initiation and progression in head and neck squamous cell carcinoma (HNSCC). | 26604082 |
| Malignant Neoplasms | Epigenetic Alterations | Although the polycomb group protein enhancer zeste homolog 2 (EZH2) is upregulated and a key epigenetic modifier implicated in various cancers, its molecular mechanism in HNSCC remains unknown. | 26604082 |
| Stomach Carcinoma | Epigenetic Alterations | A three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer. | 26607322 |
| Stomach Carcinoma | Epigenetic Alterations | Microarray data showed that 25 miRNAs were upregulated in gastric cancer patients and 6 highly expressed miRNAs (miR-18a, miR-140-5p, miR-199a-3p, miR-627, miR-629 and miR-652) were selected for validation. | 26607322 |
| Papillary thyroid carcinoma | Epigenetic Alterations | Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance. | 26611646 |
| Stomach Carcinoma | Epigenetic Alterations | However, little is known about the interaction between miRNA and the Notch signalling pathway and its role in gastric cancer (GC). | 26612211 |
| Hollings Cancer Center | Epigenetic Alterations | Abnormal miRNAs Targeting Chromosome Open Reading Frame Genes were Enriched in Microvesicles Derived from the Circulation of HCC. | 26615601 |
| Hollings Cancer Center | Epigenetic Alterations | As regulated by abnormal MVs miRNAs, functions of target Corf genes might be interrupted, which were much likely to contribute to HCC occurrence and progression. | 26615601 |
| Rheumatoid Arthritis | Epigenetic Alterations | Increased expression of long noncoding RNAs LOC100652951 and LOC100506036 in T cells from patients with rheumatoid arthritis facilitates the inflammatory responses. | 26616293 |
| Fibrosis Assessment | Epigenetic Alterations | MicroRNA expression profiling in peritoneal fibrosis. | 26616819 |
| palladium | Epigenetic Alterations | Among them, serum levels of miRNA-21-5p, miRNA-221-3p, and miRNA-327 and drained dialysate levels of miRNA-221-3p and miRNA-34a-5p were significantly correlated with peritoneal membrane functions in PD patients. | 26616819 |
| Fibrosis | Epigenetic Alterations | Anti-miRNA-21-LNA significantly inhibited miRNA-21-5p expression in the PF mouse peritoneum, inhibited peritoneal fibrous thickening, and maintained peritoneal membrane functions. | 26616819 |
| palladium | Epigenetic Alterations | The expression levels of differentially expressed miRNAs were evaluated in serum and drained dialysate and associated with peritoneal membrane functions, as measured by the peritoneal equilibrium test in 33 PD patients. | 26616819 |
| Carcinogenesis | Epigenetic Alterations | Therefore, mechanistically this data reveals that epigenetic events, at least at the level of DNA methylation, modulate the functional outcome of common genetic mutations, such as Kras(G12D), during carcinogenesis. | 26617245 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA-299-3p promotes the sensibility of lung cancer to doxorubicin through directly targeting ABCE1. | 26617714 |
| Loeys-Dietz Syndrome | Epigenetic Alterations | Long noncoding RNA AK056155 involved in the development of Loeys-Dietz syndrome through AKT/PI3K signaling pathway. | 26617788 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | microRNAs (miRNAs) play a significant role in cancer development and progression by regulating the expression of oncogenes or tumor suppressor genes. | 26617792 |
| Malignant Neoplasms | Epigenetic Alterations | Pyruvate kinase isozyme type M2 (PKM2), which is frequently up-regulated in multiple human malignancies, has been demonstrated to play a critical function in glucose metabolism, gene transcription and tumorigenesis. | 26617865 |
| Squamous cell carcinoma, Neoplasms | Epigenetic Alterations | Decreased expression of microRNA-20a promotes tumor progression and predicts poor prognosis of cutaneous squamous cell carcinoma. | 26617873 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Association of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer. | 26617875 |
| Carcinoma | Epigenetic Alterations | Long non-coding RNA (lncRNA) has an important role in carcinoma progression and prognosis. | 26617875 |
| Liver carcinoma | Epigenetic Alterations | Long non-coding RNA anti-differentiation ncRNA (lncRNA DANCR) was identified to be involved in carcinogenesis of hepatocellular carcinoma. | 26617879 |
| Intervertebral Disc Degeneration | Epigenetic Alterations | Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14. | 26620678 |
| Intervertebral Disc Degeneration | Epigenetic Alterations | Intervertebral disc degeneration (ICC)-specific miRNA profile generated by next generation sequencing. | 26620678 |
| Intervertebral disc disorder, Intervertebral Disc Degeneration | Epigenetic Alterations | Accumulating evidence suggests that microRNAs (miRNAs) play an important role in intervertebral disc degeneration (IDD), but the precise role of specific miRNAs involved in this disease remains elusive. | 26620678 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-20a in human faeces as a non-invasive biomarker for colorectal cancer. | 26621842 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Detection of microRNA (miRNA) aberrations in human faeces is a new approach for colorectal cancer (CRC) screening. | 26621842 |
| MIR20A gene | Epigenetic Alterations | miR-20a was selected from an expression microarray containing 667 miRNAs. | 26621842 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small non-coding RNA molecules, implicated in several activities like initiation, progression and prognosis of various cancers. | 26625766 |
| Malignant Neoplasms, Squamous cell carcinoma | Epigenetic Alterations | Aberrant microRNA expression has been associated with the pathogenesis of a variety of human malignancies including oral squamous cell carcinoma (SCC). | 26625772 |
| SERPINB3 wt Allele | Epigenetic Alterations | Low levels of miR-380-5p and miR-504 that directly target the 3UTR of TP53 suggest that p53 may not be repressed by these two miRNAs in OSCC. | 26625772 |
| Carcinoma of lung | Epigenetic Alterations | Evidence indicates that let-7 of microRNA may be a prognostic factor in lung cancer. | 26625972 |
| Carcinoma of lung | Epigenetic Alterations | Genetic variation in microRNA precursors could influence the processing and expression of microRNAs, which could affect the prognosis of lung cancer. | 26625972 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | This serum miRNA panel holds the potential for diagnosing ethnically diverse NSCLC patients. | 26629532 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNAs (miRNAs) are promising biomarkers for cancer detection. | 26629532 |
| Osteosarcoma | Epigenetic Alterations | Increasing evidence indicates that microRNAs (miRNAs) play critical roles in osteosarcoma (OS) occurrence and development. | 26631042 |
| cervical cancer | Epigenetic Alterations | MicroRNAs are important regulators of multiple cellular processes, and aberrant miRNA expression has been observed in human cervical cancer (CC). | 26631043 |
| palladium | Epigenetic Alterations | Furthermore, the 4-miRNA panel enabled the differentiation of HY stage 1 and 2 PD patients from controls. | 26631297 |
| Parkinson Disease | Epigenetic Alterations | A panel of four decreased serum microRNAs as a novel biomarker for early Parkinsons disease. | 26631297 |
| palladium | Epigenetic Alterations | Solexa sequencing technology and quantitative real-time PCR were applied to screen and verify altered serum miRNAs in PD patients. | 26631297 |
| palladium | Epigenetic Alterations | The four serum miRNAs may represent novel biomarkers for the early detection of PD. | 26631297 |
| Malignant Ovarian Cyst, ovarian neoplasm, Neoplasms | Epigenetic Alterations | Ovarian cancer (OV) is the most common and lethal gynecological tumor with a poor prognosis for women; however, the regulatory roles of the long non-coding RNAs (lncRNAs) in ovarian malignant progression are insufficiently understood. | 26631459 |
| Parkinson Disease | Epigenetic Alterations | Identification of a panel of five serum miRNAs as a biomarker for Parkinsons disease. | 26631952 |
| palladium | Epigenetic Alterations | This group of five miRNAs can precisely distinguish PD patients from health individuals and may be used as a potential serum-based biomarker for the diagnosis of PD. | 26631952 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) are a class of small, noncoding RNA molecules involved in carcinogenesis. | 26632718 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Genetic Variations in Key MicroRNAs are Associated With the Survival of Nonsmall Cell Lung Cancer. | 26632718 |
| Primary malignant neoplasm | Epigenetic Alterations | It has been identified that genetic variations in miRNAs contribute to cancer risk, prognosis, and survival. | 26632718 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These findings indicated that genetic variations in miRNAs (miR-184, miR-218, and miR-124) might be prognostic markers for NSCLC patients. | 26632718 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-145 Modulates Tumor Sensitivity to Radiation in Prostate Cancer. | 26632856 |
| Huntington Disease | Epigenetic Alterations | Moreover, PRC2 repressive state was significantly depleted in HD-enriched peaks, suggesting the epigenetic role of PRC2 inhibition associated with up-regulated H3K4me3 in Huntingtons disease. | 26636336 |
| Hollings Cancer Center, Primary malignant neoplasm | Epigenetic Alterations | Serum expression of four miRNAs was assessed in 150 subjects (90 cases of HCC and 60 cases without cancer) by quantitative real-time polymerase chain reaction (qRT-PCR). | 26637228 |
| Stomach Carcinoma | Epigenetic Alterations | The transcribed-ultraconserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation. | 26640143 |
| Primary malignant neoplasm | Epigenetic Alterations | Multiple sequential genetic and epigenetic alterations underlie cancer development and progression. | 26640145 |
| Lymphoma | Epigenetic Alterations | These results suggested that epigenetic silencing of miR-16 may be a key step during lymphoma development. | 26640145 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Accumulated evidence indicates that microRNA (miRNA or miR) is involved in the development of type 2 diabetes (T2DM). | 26640407 |
| Primary malignant neoplasm | Epigenetic Alterations | Genome-Wide Analysis of Long Noncoding RNA Expression Profiles in Human Xuanwei Lung Cancer. | 26642714 |
| Carcinoma of lung | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) play an important role in various biological processes involved the development and progression of lung cancer. | 26642714 |
| Malignant Neoplasms, Colorectal Cancer Pathway, Clinical Coordinator | Epigenetic Alterations | Deregulated microRNA (miRNA) expression has been shown to be involved in the pathogenesis of several types of cancers including colorectal cancer (CRC). | 26643896 |
| S100A4 protein, human | Epigenetic Alterations | Thus, determining miRNA targets of genes that play critical role in the malignant transformation is very important. | 26643896 |
| Colorectal Carcinoma | Epigenetic Alterations | MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations. | 26643896 |
| Neoplasms | Epigenetic Alterations | Here, expression levels of tumor suppressor microtubule-associated tumor suppressor 1 (MTUS1) and its regulatory miRNAs were reported. | 26643896 |
| Clinical Coordinator | Epigenetic Alterations | Accordingly, some of the overexpressed miRNAs especially the miR-135b-5p, -373-3p, 183-5p, 142-5p, 200c-3p, and 19a-3p may play key roles in CRC pathophysiology through MTUS1. | 26643896 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | In conclusion, MTUS1 targeting miRNAs may play key roles in the development of CRC by downregulating tumor suppressor MTUS1. | 26643896 |
| Pathology | Epigenetic Alterations | Epigenetic mechanisms, such as DNA methylation, may be associated with aging processes and with modulation of the risk of various pathologies, such as DM. | 26643952 |
| Hyperglycemia | Epigenetic Alterations | We identified an association between the TXNIP gene and DM through epigenetic mechanisms, related to sustained hyperglycemia levels (HbA1c >= 7%). | 26643952 |
| Pancreatic carcinoma | Epigenetic Alterations | Molecular subtypes of pancreatic cancer based on miRNA expression profiles have independent prognostic value. | 26644397 |
| Coronary Artery Disease | Epigenetic Alterations | We profiled genes and miRNAs in perivascular EAT and subcutaneous adipose tissue (SAT) of metabolically healthy patients without coronary artery disease (CAD) vs. metabolic patients with CAD. | 26645979 |
| Eating | Epigenetic Alterations | Compared with SAT, a specific tuning of miRNAs and genes points to EAT as a tissue characterized by a metabolically active and pro-inflammatory profile. | 26645979 |
| Clinical Coordinator | Epigenetic Alterations | This novel approach allowed us to validate many previously published results using various techniques to profile miRNAs in CRC tissues or cell lines and to characterize true miRNA signatures highly expressed in colon/rectum (CR) or CRC tissues. | 26646696 |
| Clinical Coordinator | Epigenetic Alterations | According to our results, miR-21, a miRNA that is up-regulated in CRC, and miR-143, a miRNA that is down-regulated in CRC, are the two miRNAs that dominated the miRNA population in CR tissues, and probably are also the most important miRNAs in CRCs. | 26646696 |
| Primary malignant neoplasm | Epigenetic Alterations | Using TaqMan miRNA qPCR, we detected the relative expression of some of the CRC miRNAs in 10 CRC cell lines, validated their dysregulation under cancer condition, and provided possible explanation for their dysregulation, which could be caused by APC, KRAS, or TP53 mutations. | 26646696 |
| Clinical Coordinator | Epigenetic Alterations | We believe these results will provide a new direction in future miRNA-related CRC development studies, and application of miRNAs in CRC diagnosis/prognosis, and therapy. | 26646696 |
| Colorectal Carcinoma | Epigenetic Alterations | Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol. | 26646696 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | To explore the role of miRNAs in colorectal cancers (CRC), we have deep sequenced 48 pairs of frozen CRC samples, of which 44 pairs produced high quality sequencing data. | 26646696 |
| Breast Carcinoma, Mammary Neoplasms | Epigenetic Alterations | This epigenetic silencing is also seen in human breast cancer cell lines and in a majority of human breast tumor tissues. | 26646903 |
| Malignant Neoplasms | Epigenetic Alterations | The epigenetic silencing of MORT in a large majority of the common human cancers suggests a potential fundamental role in cellular immortalization during human carcinogenesis. | 26646903 |
| Prostate Cancer Pathway, Metastasis | Epigenetic Alterations | MicroRNA-335 and -543 suppress bone metastasis in prostate cancer via targeting endothelial nitric oxide synthase. | 26647850 |
| CHOANAL ATRESIA, POSTERIOR, Metastasis, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Even though the regulatory role of microRNAs (miRNAs) in the control of tumor metastases has been well described in numerous types of cancer, the importance in bone metastasis of PCa remains largely unknown. | 26647850 |
| Malignant tumor of colon | Epigenetic Alterations | Identifying molecular subtypes in human colon cancer using gene expression and DNA methylation microarray data. | 26647925 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | MicroRNA-106b functions as an oncogene in renal cell carcinoma by affecting cell proliferation, migration and apoptosis. | 26648244 |
| Breast Cancer Cell | Epigenetic Alterations | MicroRNA-106b (miR-106b) has been described as an oncogene in several types of human cancer. | 26648244 |
| Metastasis, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2. | 26648487 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNAs (miRs) have been found to play important roles in mediating a variety of biological processes in human cancers, including tumor cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). | 26648487 |
| Paraganglioma | Epigenetic Alterations | Epigenetic Mutation of the Succinate Dehydrogenase C Promoter in a Patient With Two Paragangliomas. | 26652933 |
| PGLS gene, Gastrointestinal Stromal Tumors, Carney Triad | Epigenetic Alterations | This report provides evidence that SDHC promoter methylation can cause PGLs due to SDHC inactivation, emphasizing the importance of considering epigenetic changes and functional readouts in the genetic evaluation of patients not only with GISTs and Carney triad but also with PPGL. | 26652933 |
| Degenerative polyarthritis | Epigenetic Alterations | Elevated expression of microRNA-30b in osteoarthritis and its role in ERG regulation of chondrocyte. | 26653555 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) for the association between DNA methylation level and the risk of RCC. | 26655847 |
| Parkinson Disease | Epigenetic Alterations | Increased epigenetic age and granulocyte counts in the blood of Parkinsons disease patients. | 26655927 |
| SF3B1 wt Allele | Epigenetic Alterations | This study identifies microRNAs(miRNA) and miRNA targets that might represent leukemic transformation markers for MDS. | 26657287 |
| Hepatitis B, Liver carcinoma | Epigenetic Alterations | Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma. | 26660680 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | DNA methylation mainly affects tumor suppressor genes in the development of hepatocellular carcinoma (HCC). | 26660680 |
| Hollings Cancer Center | Epigenetic Alterations | Aberrant sera DNA methylation of CDH1, DNMT3b and ESR1 gene promoters could be a biomarker in the early diagnosis of HBV-related HCC. | 26660680 |
| Primary malignant neoplasm | Epigenetic Alterations | Accumulation of data indicates that misregulated long noncoding RNAs (lncRNAs) are implicated in cancer tumorigenesis and progression and might be served as diagnosis and prognosis biomarker or potential therapeutic targets. | 26662309 |
| Breast Carcinoma | Epigenetic Alterations | Circulating long noncoding RNA GAS5 as a potential biomarker in breast cancer for assessing the surgical effects. | 26662314 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Prognostic role of microRNA-100 in patients with bladder cancer. | 26662386 |
| Pancreatic carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer. | 26662405 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | It has been shown that microRNA-215 (miR-215) is dysregulated in several human malignancies, and this correlates with tumor progression. | 26662405 |
| Neoplasms | Epigenetic Alterations | microRNA-218 (miR-218) is a vertebrate-specific miRNA that plays a crucial role in tumorigenesis and tumor progression. | 26662432 |
| Pancreatic carcinoma | Epigenetic Alterations | Reduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosis. | 26662432 |
| melanoma | Epigenetic Alterations | Expression of microRNA-106b and its clinical significance in cutaneous melanoma. | 26662433 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-106b (miR-106b) is overexpressed in various types of cancers and is associated with the regulation of carcinogenic processes. | 26662433 |
| Liver carcinoma | Epigenetic Alterations | Systemic genome screening identifies the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma. | 26663434 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Sequence variation, methylation differences, and transcriptional changes in desmoplakin (DSP) have been observed in patients with idiopathic pulmonary fibrosis (IPF). | 26669357 |
| Graft-vs-Host Disease | Epigenetic Alterations | Using genome-wide DNA methylation profiling, we showed that epigenetic signatures underlying aGVHD severity in recipients correspond to immune pathways relevant to aGVHD etiology. | 26669438 |
| Graft-vs-Host Disease | Epigenetic Alterations | We discovered 31 DNA methylation marks in donors that associated with aGVHD severity status in recipients, and demonstrated strong predictive performance of these markers in internal cross-validation experiments (AUC = 0.98, 95% CI = 0.96-0.99). | 26669438 |
| Acute GVH disease | Epigenetic Alterations | A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation. | 26669438 |
| Degenerative polyarthritis | Epigenetic Alterations | No difference was observed for DNA methylation levels in the SMAD3 promoter region between OA cases and controls. | 26669923 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma. | 26670229 |
| Gastric Gastrointestinal Stromal Tumor, Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in carcinogenesis, but the global miRNA expression profile in gastric stromal tumor tissues remains unclear. | 26670434 |
| Gastric Gastrointestinal Stromal Tumor | Epigenetic Alterations | It was concluded that gastric stromal tumor displays a unique miRNA signature. | 26670434 |
| Gastric Gastrointestinal Stromal Tumor | Epigenetic Alterations | Altered expression profile of micrornas in gastric stromal tumor. | 26670434 |
| Gastric Gastrointestinal Stromal Tumor | Epigenetic Alterations | The dysregulated microRNAs were validated by quantitative RT-PCR in 30 pairs of gastric stromal tumor tissues. | 26670434 |
| Gastric Gastrointestinal Stromal Tumor | Epigenetic Alterations | The results showed that there were 12 differently expressed microRNAs in gastric stromal tumor tissues, among which 10 miRNAs were down-regulated, and 2 were up-regulated (P<0.05). | 26670434 |
| Gastric Gastrointestinal Stromal Tumor | Epigenetic Alterations | miR-3178 and miR-193a-5p function as suppressive microRNAs, and they may also become diagnosis and treatment targets for gastric stromal tumor. | 26670434 |
| Asthma Pathway | Epigenetic Alterations | Our goal was to determine whether DNA methylation was associated with predisposition to asthma and whether such a relationship was independent from genetic association. | 26671913 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | High-throughput qRT-PCR validation of blood microRNAs in non-small cell lung cancer. | 26672767 |
| Carcinoma of lung, Chronic Obstructive Airway Disease | Epigenetic Alterations | MiRNAs that were identified as relevant for the separation between lung cancer and COPD by both qRT-PCR and the array-based studies included hsa-miR-26a-5p, hsa-miR-328-3p and hsa-miR-1224-3p. | 26672767 |
| Primary malignant neoplasm | Epigenetic Alterations | Methylation is a common epigenetic modification which may play a crucial role in cancer development. | 26674784 |
| Subarachnoid Hemorrhage, Aneurysmal | Epigenetic Alterations | Circulating microRNA 132-3p and 324-3p Profiles in Patients after Acute Aneurysmal Subarachnoid Hemorrhage. | 26675167 |
| Noninfiltrating Intraductal Carcinoma, S-Adenosylhomocysteine | Epigenetic Alterations | However, there were no significant differences in fold changes between SAH patients with and without DCI [fold change ratios (mean+/-SD): 2.7+/-4.2 and 1.1+/-1.1 for miRNA-132 and miRNA-324]. | 26675167 |
| Noninfiltrating Intraductal Carcinoma, S-Adenosylhomocysteine | Epigenetic Alterations | We demonstrated that 99 miRNAs were found to be dysregulated in the SAH patient group with DCI. | 26675167 |
| Liver carcinoma | Epigenetic Alterations | Up-regulation of microRNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1. | 26676187 |
| Squamous cell carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma. | 26676674 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Our recent studies of microRNA (miRNA) expression signatures of human cancers showed that the microRNA-29 family (miR-29a, miR-29b and miR-29c) significantly reduced cancer tissues compared to normal tissues. | 26676674 |
| Malignant Solid Neoplasm | Epigenetic Alterations | Long non-coding RNA (lncRNA) is a variety of the human transcriptome that does not code for proteins and plays an important role in the development and progression of multiple solid malignant tumors. | 26676849 |
| Malignant Neoplasms | Epigenetic Alterations | miRNAs are currently considered to be important regulators for cell behavior and are deregulated in many malignancies. | 26676972 |
| Childhood Leukemia, Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNA-9 promotes proliferation of leukemia cells in adult CD34-positive acute myeloid leukemia with normal karyotype by downregulation of Hes1. | 26678889 |
| Mature B-Cell Neoplasm | Epigenetic Alterations | Global measures of peripheral blood-derived DNA methylation as a risk factor in the development of mature B-cell neoplasms. | 26679037 |
| Primary malignant neoplasm | Epigenetic Alterations | Previous research has shown that microRNA-141 (miR-141) expression levels are associated with survival in several types of cancer. | 26681225 |
| TRPV6 gene | Epigenetic Alterations | These results suggest that the DNA methylation status of the TSDR is an important hallmark to define this heterogeneous disease and to predict ATL patient prognosis. | 26681759 |
| TRPV6 gene | Epigenetic Alterations | Here, we focus on the functional and clinical relationship between the epigenetic pattern of the TSDR and ATL. | 26681759 |
| TRPV6 gene | Epigenetic Alterations | Thus, the epigenetic analysis of the FOXP3 gene identified a distinct subtype with Treg properties in heterogeneous ATL. | 26681759 |
| MIR21 gene, Heart Diseases | Epigenetic Alterations | MIR21 encodes a microRNA (miR-21) that has previously been shown to be associated with the development of heart disease. | 26681806 |
| Heart failure | Epigenetic Alterations | Identification of cardiac-related circulating microRNA profile in human chronic heart failure. | 26683101 |
| Chronic heart failure | Epigenetic Alterations | During chronic heart failure, levels of circulating miRNAs endued with characteristics of diseased cells could be identified as biomarkers. | 26683101 |
| Heart failure | Epigenetic Alterations | Four cardiac fibroblast-derived miRNAs (miR-660-3p, miR-665, miR-1285-3p and miR-4491) were found significantly upregulated in heart and plasma during heart failure. | 26683101 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Genome-wide profiling of DNA methylation and gene expression in esophageal squamous cell carcinoma. | 26683359 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Previous studies have suggested that DNA methylation involved in the development of ESCC. | 26683359 |
| Carcinogenesis, Squamous cell carcinoma of esophagus | Epigenetic Alterations | The identification of whole-genome DNA methylation patterns and gene expression profiles in ESCC provides new insight into the carcinogenesis of ESCC and represents a promising avenue through which to investigate novel therapeutic targets. | 26683359 |
| Islet Cell Tumor | Epigenetic Alterations | High Expression of MicroRNA-196a Indicates Poor Prognosis in Resected Pancreatic Neuroendocrine Tumor. | 26683934 |
| Islet Cell Tumor, Well Differentiated Pancreatic Endocrine Tumor | Epigenetic Alterations | There is limited data on miRNA expression in pancreatic neuroendocrine tumors (PanNETs). | 26683934 |
| Well Differentiated Pancreatic Endocrine Tumor | Epigenetic Alterations | When PanNETs were stratified into high (n = 10) and low (n = 27) miRNA-196a expression groups, miRNA-196a-high PanNETs were significantly associated with advanced pathologic T stage (50.0% vs 7.4%), N stage (50.0% vs 3.7%), higher mitotic counts (60.0% vs 3.7%), and higher Ki-67-labeling indices (60.0% vs 22.2%). | 26683934 |
| Well Differentiated Pancreatic Endocrine Tumor | Epigenetic Alterations | MiRNA-196a level may be a promising prognostic marker of recurrence in resected PanNETs, although further experimental investigation would be required. | 26683934 |
| melanoma | Epigenetic Alterations | Inhibition of CCL2 and of the selected miRNAs restored both the cell apoptosis and the drug efficacy in resistant melanoma cells. | 26684239 |
| melanoma | Epigenetic Alterations | Therefore, CCL2 and miRNAs are potential prognostic factors and attractive targets for counteracting treatment resistance in metastatic melanoma. | 26684239 |
| Malignant neoplasm of urinary bladder, Hereditary Diseases | Epigenetic Alterations | Bladder cancer is a molecular disease driven by the accumulation of genetic, epigenetic, and environmental factors. | 26685928 |
| Degenerative polyarthritis | Epigenetic Alterations | The microRNA-29 family in cartilage homeostasis and osteoarthritis. | 26687115 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNAs have been shown to function in cartilage development and homeostasis, as well as in progression of osteoarthritis. | 26687115 |
| Degenerative polyarthritis | Epigenetic Alterations | These data identify the miR-29 family as microRNAs acting across development and progression of OA. | 26687115 |
| Anaplastic large B-cell lymphoma, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | MicroRNA 25, microRNA 145, and microRNA 210 as biomarkers for predicting the efficacy of maintenance treatment with pemetrexed in lung adenocarcinoma patients who are negative for epidermal growth factor receptor mutations or anaplastic lymphoma kinase translocations. | 26687391 |
| Neoplasms | Epigenetic Alterations | Phosphatase and tensin homolog (PTEN) and p16INK4a (p16) genes are tumor suppressor genes, associated with epigenetic alterations. | 26687648 |
| Primary malignant neoplasm | Epigenetic Alterations | PTEN and p16 promoter hypermethylation is a major epigenetic silencing mechanism leading to cancer. | 26687648 |
| Primary malignant neoplasm | Epigenetic Alterations | Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population. | 26688807 |
| Neurocognitive Disorders | Epigenetic Alterations | Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders. | 26689571 |
| Neurocognitive Disorders | Epigenetic Alterations | While these results suggest that the increased risk of a neurocognitive disorder due to HIV might be mediated by an epigenetic aging mechanism, future studies will be needed to validate the findings and dissect causal relationships and downstream effects. | 26689571 |
| Neoplastic Syndromes, Hereditary | Epigenetic Alterations | This report highlights the role for BRCC3 in cardiovascular physiology and disease, and demonstrates that in some complex hereditary syndromes full diagnostics may require the examination of both genetic and epigenetic events. | 26691666 |
| Esophageal carcinoma | Epigenetic Alterations | Response of esophageal cancer cells to epigenetic inhibitors is mediated via altered thioredoxin activity. | 26692290 |
| Carcinoma of larynx | Epigenetic Alterations | Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma. | 26694163 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNAs (miRNAs) are potential noninvasive biomarkers for cancer detection. | 26695145 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Identification of serum miRNAs by nano-quantum dots microarray as diagnostic biomarkers for early detection of non-small cell lung cancer. | 26695145 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We initially detected expression of 12 miRNAs using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) in preoperative serum samples of 94 NSCLC patients and 58 healthy controls. | 26695145 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We further validated our results using the fluorescence quantum dots liquid bead array for differentially expressed miRNAs in serum samples of 70 NSCLC patients and 54 healthy controls. | 26695145 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | A predictive model of miRNAs for NSCLC was derived by multivariate logistic regression. | 26695145 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We found that five serum miRNAs (miR-16-5p, miR-17b-5p, miR-19-3p, miR-20a-5p, and miR-92-3p) were significantly downregulated in NSCLC, while miR-15b-5p was significantly upregulated (p < 0.05). | 26695145 |
| Neoplasms | Epigenetic Alterations | In addition, the expression of serum miR-106-5p was higher in stage I than in stages IIa-IIIb, and no significant association was observed between expression of miRNAs and other variables including pathological type, tumor size, and lymph nodes status. | 26695145 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Six serum miRNAs could potentially serve as noninvasive diagnostic biomarkers for resectable NSCLC. | 26695145 |
| Sarcoidosis, Pulmonary | Epigenetic Alterations | There is limited information regarding the regulation of cytokine/chemokine-receptor network in bronchoalveolar lavage (BAL) cells in pulmonary sarcoidosis, suggesting contribution of miRNAs and transcription factors. | 26696750 |
| Liver carcinoma | Epigenetic Alterations | A possible role of microRNAs as predictive markers for the recurrence of hepatocellular carcinoma after liver transplantation. | 26697811 |
| Neoplasms, Cessation of life | Epigenetic Alterations | Using the most significant miRNAs in this screening cohort, we could develop a predictive score, which combined the expression levels of miR-214, miR-3187 and the Milan criteria, and we could define low- and high-risk groups for tumour recurrence and death. | 26697811 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA-148a represents an independent prognostic marker in bladder cancer. | 26700670 |
| Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | Circulating microRNA-203 predicts prognosis and metastasis in human colorectal cancer. | 26701878 |
| Metastasis, Neoplasm Metastasis | Epigenetic Alterations | In spite of the important function of microRNA (miR)-203 in cancer metastasis, its clinical significance in CRC metastasis remains unknown. | 26701878 |
| Malignant Glioma | Epigenetic Alterations | MicroRNA-21 (miR-21) is the most consistently over-expressed microRNA (miRNA) in malignant gliomas. | 26701969 |
| Neurodegenerative Disorders, Amyotrophic Lateral Sclerosis | Epigenetic Alterations | Recent evidence suggests that post-transcriptional regulation and epigenetic mechanisms, such as microRNAs, underlie the onset and progression of neurodegenerative disorders; therefore, altered microRNA expression may result in the dysregulation of key genes and biological pathways that contribute to the development of sporadic amyotrophic lateral sclerosis. | 26704906 |
| Amyotrophic Lateral Sclerosis | Epigenetic Alterations | Furthermore, we report a global reduction of mature microRNAs, alterations in microRNA processing, and support for a role of the nucleotide binding protein, TAR DNA binding protein 43, in regulating sporadic amyotrophic lateral sclerosis-associated microRNAs, thereby offering a potential underlying mechanism for sporadic amyotrophic lateral sclerosis. | 26704906 |
| Chronic Kidney Diseases | Epigenetic Alterations | Renal microRNA- and RNA-profiles in progressive chronic kidney disease. | 26707063 |
| Chronic Kidney Diseases | Epigenetic Alterations | MicroRNAs (miRNAs) contribute to chronic kidney disease (CKD) progression via regulating mRNAs involved in renal homeostasis. | 26707063 |
| Chronic Kidney Diseases | Epigenetic Alterations | These results suggest the involvement of specific miRNAs and mRNAs in biological pathways associated with the progression of CKD. | 26707063 |
| Liver carcinoma | Epigenetic Alterations | Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by regulating vimentin. | 26707238 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-519a promotes tumor growth by targeting PTEN/PI3K/AKT signaling in hepatocellular carcinoma. | 26708293 |
| Hollings Cancer Center | Epigenetic Alterations | Previous miRNA array data showed that miR-519a was upregulated in HCC tissues compared to adjacent non-tumor tissues. | 26708293 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | MicroRNAs (miRNAs) have been found to play fundamental roles in the pathogenesis of hepatocellular carcinoma (HCC). | 26708293 |
| Neoplasms, Renal Cell Carcinoma Pathway | Epigenetic Alterations | MicroRNA-20b-5p functions as a tumor suppressor in renal cell carcinoma by regulating cellular proliferation, migration and apoptosis. | 26708577 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, increasing evidence has suggested that microRNAs (miRNAs) are involved in the proliferation, invasion and apoptosis of various types of human cancer cells. | 26708577 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Diagnostic and predictive significance of serum microRNA-7 in esophageal squamous cell carcinoma. | 26708917 |
| Neoplasms | Epigenetic Alterations | MicroRNA-7 has been reported to participate in tumorigenesis and progression by several signaling pathways in various tumors. | 26708917 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA (miRNA) expression profile analysis indicated that miR-205 was upregulated in bladder cancer tissue compared to healthy tissue. | 26715266 |
| Breast Carcinoma | Epigenetic Alterations | Our findings indicated increased frequency of hypermethylation of PTEN promoter in the studied patients and their relatives that could be considered as one of the epigenetic factors affecting the risk of breast cancer in Iranians. | 26715274 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-584-3p, a novel tumor suppressor and prognostic marker, reduces the migration and invasion of human glioma cells by targeting hypoxia-induced ROCK1. | 26715733 |
| Glioma, Neoplasms | Epigenetic Alterations | Here, we report that microRNA-584-3p (miR-584-3p) is up-regulated in hypoxic glioma cells and in high-grade human glioma tumors (WHO grades III-IV) relative to normoxic cells and to low-grade tumors (WHO grades I-II), respectively. | 26715733 |
| Liver diseases, Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | The results provide evidence for identifying epigenetic factors of elivated ALT and may be useful for risk assessment and personalized medicine of liver diseases such as non-alcoholic fatty liver disease (NAFLD). | 26717317 |
| Malignant neoplasm of breast | Epigenetic Alterations | Taken together, these findings provide evidence that a miRNA expression signature can be developed to aid existing methods to determine the risk of recurrence for women with estrogen receptor positive breast cancers treated with endocrine therapy. | 26717565 |
| Breast Carcinoma, Aggressive behavior, Primary malignant neoplasm | Epigenetic Alterations | Altered expression of miRNAs has been observed in many types of cancer, including breast cancer, and shown to contribute to cancer growth, aggressiveness, and response to therapies. | 26717565 |
| PITX2 gene | Epigenetic Alterations | Additional miRNAs were found to positively correlate with RS, including miR-377-5p, miR-633b, miR-548t and miR-3648. | 26717565 |
| Neoplasms | Epigenetic Alterations | Pathway analysis of putative and validated targets suggests that these miRNAs may have a diverse range of functions that may contribute to tumor recurrence. | 26717565 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-b1. | 26717894 |
| Neoplasm Metastasis | Epigenetic Alterations | Recently, microRNAs (miRs) have been demonstrated to play important roles in the regulation of cancer metastasis. | 26717894 |
| Cerebral Infarction, Diabetes Mellitus | Epigenetic Alterations | The Expression of microRNA-223 and FAM5C in Cerebral Infarction Patients with Diabetes Mellitus. | 26717922 |
| Neoplasms, Refractory Cytopenia of Childhood | Epigenetic Alterations | Aberrant expression of miRNA-130b has previously been reported in tumors, however, its role in RCC remains to be elucidated. | 26717956 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A. MicroRNA-206 (miR-206) has been discovered to have anticancer properties in different tissues. | 26718123 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | CRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer. | 26718216 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | CRCT1 expression was inversely correlated with the levels of microRNA-520 g (miR-520 g) in ESCC tissues, and CRCT1 was identified as a direct target gene of miR-520 g in ESCC cells. | 26718216 |
| Stomach Carcinoma | Epigenetic Alterations | Differential expression profiles of long non-coding RNAs reveal potential biomarkers for identification of human gastric cancer. | 26718650 |
| Cardiovascular, Coronary Artery Disease | Epigenetic Alterations | miRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease. | 26720041 |
| Cardiovascular | Epigenetic Alterations | Elevated levels of miRNA-197 and miRNA-223 reliably predicted future cardiovascular death in the overall group (miRNA-197: hazard ratio (HR) 1.77 per one standard deviation (SD) increase (95% confidence interval (CI) 1.20; 2.60), p = 0.004, C-index 0.78; miRNA-223: HR 2.23 per one SD increase (1.20; 4.14), p = 0.011, C-index 0.80). | 26720041 |
| CO-methylating acetyl-CoA synthase activity | Epigenetic Alterations | In ACS patients the prognostic power of both miRNAs was even higher (miRNA-197: HR 2.24 per one SD increase (1.25; 4.01), p = 0.006, C-index 0.89); miRA-223: HR 4.94 per one SD increase (1.42; 17.20), p = 0.012, C-index 0.89). | 26720041 |
| Cardiovascular | Epigenetic Alterations | Serum-derived circulating miRNA-197 and miRNA-223 were identified as predictors for cardiovascular death in a large patient cohort with CAD. | 26720041 |
| Coronary Artery Disease, Cardiovascular Diseases | Epigenetic Alterations | Circulating microRNAs (miRNAs) have been described as potential diagnostic biomarkers in cardiovascular disease and in particular, coronary artery disease (CAD). | 26720041 |
| Fungal keratitis | Epigenetic Alterations | Human Corneal MicroRNA Expression Profile in Fungal Keratitis. | 26720440 |
| Fungal keratitis | Epigenetic Alterations | This is, to our knowledge, the first report on comprehensive human corneal miRNA expression profile in fungal keratitis. | 26720440 |
| Fungal keratitis | Epigenetic Alterations | By deep sequencing, 75 miRNAs were identified as differentially expressed with fold change greater than 2 and probability score greater than 0.9 in fungal keratitis corneas. | 26720440 |
| Fungal keratitis | Epigenetic Alterations | Several miRNAs with high expression in fungal keratitis point toward their potential role in regulation of pathogenesis. | 26720440 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-194 acts as a prognostic marker and inhibits proliferation in hepatocellular carcinoma by targeting MAP4K4. | 26722431 |
| Primary malignant neoplasm, Hollings Cancer Center, Liver carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) play a crucial role in cancer development and progression of hepatocellular carcinoma (HCC). | 26722431 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA UCA1 may be a novel diagnostic and predictive biomarker in plasma for early gastric cancer. | 26722487 |
| Neoplasms | Epigenetic Alterations | MicroRNA (miR) has been known to be of unique expressional patterns in various tumors and may work as potential tumor markers for clinical use. | 26722506 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-203 (miRNA-203 or miR-203) has previously shown significant alteration in a number of cancers. | 26722525 |
| Diabetic Foot | Epigenetic Alterations | Quantification of the differential expression levels of microRNA-203 in different degrees of diabetic foot. | 26722550 |
| Diabetic foot ulcer | Epigenetic Alterations | Skin-enriched microRNA-203 (miR-203) was readily detected in skin tissue samples, and, in contrast to normal skin tissue, samples from patient with diabetic foot ulcers significantly have a higher expression level in miR-203. | 26722550 |
| Malignant Neoplasms | Epigenetic Alterations | Accumulating evidence suggests that polymorphisms of miRNAs were associated with the tumorigenesis of various cancers, including PTC. | 26722556 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA-542-3p suppresses cellular proliferation of bladder cancer cells through post-transcriptionally regulating survivin. | 26723509 |
| Rheumatoid Arthritis | Epigenetic Alterations | microRNA-126 targeting PIK3R2 promotes rheumatoid arthritis synovial fibro-blasts proliferation and resistance to apoptosis by regulating PI3K/AKT pathway. | 26723864 |
| Breast Carcinoma, Hereditary | Epigenetic Alterations | Relationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer. | 26723934 |
| Prostate Cancer Pathway | Epigenetic Alterations | Overexpression of the Long Non-coding RNA SChLAP1 Independently Predicts Lethal Prostate Cancer. | 26724257 |
| CHOANAL ATRESIA, POSTERIOR, Malignant neoplasm of prostate | Epigenetic Alterations | The long noncoding RNA SChLAP1 is overexpressed in a subset of prostate cancers (PCa), and high SChLAP1 expression by in situ hybridization (ISH) independently predicts biochemical recurrence after radical prostatectomy. | 26724257 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic alterations of DNA mismatch repair (MMR) genes are associated with risk of gastric cancer (GC) by causing microsatellite instability (MSI). | 26724419 |
| Chronic somatic dysfunction, Tubular atrophy, Interstitial Fibrosis Assessment | Epigenetic Alterations | Altered Expression of MicroRNAs Following Chronic Allograft Dysfunction with Interstitial Fibrosis and Tubular Atrophy. | 26725559 |
| Sjogrens Syndrome | Epigenetic Alterations | Defective DNA methylation in salivary gland epithelial acini from patients with Sjogrens syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration. | 26725749 |
| Sjogrens Syndrome", Perceived stress scale | Epigenetic Alterations | The pathogenesis of primary Sjogrens syndrome (pSS) is complex, in part due to DNA methylation abnormalities. | 26725749 |
| Perceived stress scale | Epigenetic Alterations | In conclusion, our results highlight the importance of DNA methylation in the pathophysiology of pSS and to the emergence of anti-SSB/La Ab. | 26725749 |
| Neoplasms | Epigenetic Alterations | Illumina high-throughput sequencing was used to obtain miRNA expression profiles of paired tumor and adjacent normal tissues from one patient received TAI 1 week before the operation and another patient directly underwent an operation. | 26728674 |
| melanoma | Epigenetic Alterations | MicroRNA-21 expression and its pathogenetic significance in cutaneous melanoma. | 26731559 |
| melanoma | Epigenetic Alterations | We previously reported that microRNA-21 (miR-21) was strongly expressed in melanoma relative to naevi and now sought to further assess the significance of this by assessing its relationship with its putative target, PTEN. | 26731559 |
| ovarian neoplasm | Epigenetic Alterations | What is more, aberrant expression of microRNA-21 (miR-21) has been shown to be involved in oncogenesis, but the relationship between miR-21 and HE4 in ovarian cancer is not clear. | 26733162 |
| Ovarian Carcinoma | Epigenetic Alterations | TaqMan((r)) MicroRNA (miRNA) assays were employed to detect the expression of miR-21 in the ovarian carcinoma. | 26733162 |
| Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | DNA methylation has been posited as a mechanism linking psychological factors to CHD risk. | 26733571 |
| Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | Such epigenetic changes may represent biological pathways that mediate the effects of psychological factors on CHD. | 26733571 |
| Breast Carcinoma | Epigenetic Alterations | Circulating microRNA-based screening tool for breast cancer. | 26734993 |
| Breast Carcinoma | Epigenetic Alterations | Here, their plasmatic levels were measured to be used as an alternative screening procedure to mammography for breast cancer diagnosis.A plasma miRNA profile was determined by RT-qPCR in a cohort of 378 women. | 26734993 |
| Malignant neoplasm of breast, Neoplasms | Epigenetic Alterations | A diagnostic model was designed based on the expression of 8 miRNAs measured first in a profiling cohort composed of 41 primary breast cancers and 45 controls, and further validated in diverse cohorts composed of 108 primary breast cancers, 88 controls, 35 breast cancers in remission, 31 metastatic breast cancers and 30 gynecologic tumors.A receiver operating characteristic curve derived from the 8-miRNA random forest based diagnostic tool exhibited an area under the curve of 0.81. | 26734993 |
| Breast Carcinoma | Epigenetic Alterations | The miRNA signature correctly identified patients with metastatic breast cancer. | 26734993 |
| Breast Carcinoma, Pathology | Epigenetic Alterations | Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. | 26734993 |
| Malignant neoplasm of breast, Breast Carcinoma, Malignant Female Reproductive System Neoplasm | Epigenetic Alterations | The use of the classification model on cohorts of patients with breast cancers in remission and with gynecologic cancers yielded prediction distributions similar to that of the control group.Using a multivariate supervised learning method and a set of 8 circulating miRNAs, we designed an accurate, minimally invasive screening tool for breast cancer. | 26734993 |
| Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Double-strand break repair and colorectal cancer: gene variants within 3 UTRs and microRNAs binding as modulators of cancer risk and clinical outcome. | 26735576 |
| Primary malignant neoplasm | Epigenetic Alterations | Initially identified as a molecule that regulates the final step of glycolysis, the M2 isoform of pyruvate kinase (PKM2) was recently reported to have a central role in the metabolic reprogramming of cancer cells as well as participating in cell cycle progression and gene transcription. | 26739387 |
| Colorectal Carcinoma, Adenoma | Epigenetic Alterations | MicroRNA profiles in colorectal carcinomas, adenomas and normal colonic mucosa: variations in miRNA expression and disease progression. | 26740022 |
| Adenoma | Epigenetic Alterations | A total of 1893 carcinoma/normal-paired samples and 290 adenoma tissue samples were run on the Agilent Human miRNA Microarray V19.0 which contained 2006 miRNAs. | 26740022 |
| Carcinoma, Colorectal Cancer Pathway, Adenoma | Epigenetic Alterations | Our data suggest that miRNAs are highly dysregulated in colorectal tissue among individuals with colorectal cancer; the pattern of disruption varies by miRNA as tissue progresses from normal to adenoma to carcinoma. | 26740022 |
| Carcinoma, Adenoma | Epigenetic Alterations | Roughly half of these differentially expressed miRNAs showed a progression in levels of expression from normal to adenoma to carcinoma tissue. | 26740022 |
| Carcinoma, Adenoma | Epigenetic Alterations | Other miRNAs appeared to be altered at the normal to adenoma stage, while others were only altered at the adenoma to carcinoma stage or only at the normal to carcinoma stage. | 26740022 |
| Impaired cognition, "Alzheimers Disease", Amnesia, CTCAE | Epigenetic Alterations | Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimers Disease and Amnesic Mild Cognitive Impairment. | 26742120 |
| Carcinogenesis, Stomach Carcinoma | Epigenetic Alterations | Expression of microRNAs (miRNAs) has been closely linked to the carcinogenesis of gastric cancer and has been considered as a powerful prognostic marker. | 26742429 |
| melanoma | Epigenetic Alterations | microRNA-10b is a prognostic biomarker for melanoma. | 26743475 |
| melanoma | Epigenetic Alterations | Taken together, these data suggest that miR-10b is a new prognostic microRNA for melanoma and that there could be a place for microRNA analysis in stratifying melanoma for therapy. | 26743475 |
| melanoma | Epigenetic Alterations | We analyzed 377 microRNAs in 79 primary melanomas and 32 metastases using a split sample discovery strategy. | 26743475 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | From our results we conclude that miR-613 may act as a tumor suppressor in NSCLC and may serve as a tool for miRNA-based NSCLC therapy. | 26744345 |
| Malignant Neoplasms, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Deregulation of microRNAs (miRNAs) has been associated with a variety of cancers, including non-small cell lung cancer (NSCLC). | 26744345 |
| Fibrosis Assessment | Epigenetic Alterations | Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis. | 26744410 |
| Degenerative polyarthritis | Epigenetic Alterations | Genome-wide DNA methylation profile implicates potential cartilage regeneration at the late stage of knee osteoarthritis. | 26746145 |
| Degenerative polyarthritis | Epigenetic Alterations | Our data suggested the changes in DNA methylation occurred at the late stage of OA. | 26746145 |
| Neoplasms | Epigenetic Alterations | Collectively, our work suggests EZH2 and its miRNA interactors may serve as promising biomarkers for progression of astrocytic tumors and may offer novel therapeutic strategies. | 26746204 |
| Neoplasms | Epigenetic Alterations | Interestingly, EZH2 associated miRNAs were predicted to target 25 genes in glioma-pathway, suggesting their role in tumor formation or progression. | 26746204 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration. | 26750768 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Single-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) are considered potential markers of cancer risk and prognosis in various cancers. | 26753964 |
| Pancreatic Ductal Adenocarcinoma, Neoplasms | Epigenetic Alterations | RASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression, chromosomal status and epigenetic changes. | 26754001 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Predictive value of plasma miRNA-718 for esophageal squamous cell carcinoma. | 26756617 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Plasma miRNA-718 expression level of ESCC patients was significantly lower than that of healthy controls. | 26756617 |
| Tetranitromethane, Metastasis | Epigenetic Alterations | Plasma miRNA-718 expression level was inversely correlated with the lymph node metastasis and TNM stage. | 26756617 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Plasma miRNA-718 is downregulated in ESCC patients and might serve as a potential diagnostic marker for ESCC. | 26756617 |
| Malignant Neoplasms | Epigenetic Alterations | Increasing evidence demonstrated that circulating miRNAs could serve as meaningfully non-invasive and reliable biomarkers for the detection of various cancers. | 26756617 |
| Osteoporosis | Epigenetic Alterations | Our data indicate that the food-derived compound SFN epigenetically stimulates osteoblast activity and diminishes osteoclast bone resorption, shifting the balance of bone homeostasis and favoring bone acquisition and/or mitigation of bone resorptionin vivo Thus, SFN is a member of a new class of epigenetic compounds that could be considered for novel strategies to counteract osteoporosis. | 26757819 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have been proved to play important roles in the tumorigenesis and development of human hepatocellular carcinoma (HCC). | 26758762 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion. | 26761212 |
| Malignant Glioma | Epigenetic Alterations | The RNA-binding protein PCBP2, an oncogenic protein in human malignant gliomas, is an essential regulator of mRNA and miRNA biogenesis, stability and activity. | 26761212 |
| Arteriosclerosis | Epigenetic Alterations | Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques. | 26764138 |
| atherosclerotic | Epigenetic Alterations | Histone acetylation/methylation in the cells within atherosclerotic plaques was determined by immunohistochemistry. | 26764138 |
| Atherosclerotic lesion | Epigenetic Alterations | Increased histone acetylation was observed on H3K9 and H3K27 in smooth muscle cells (SMCs) in advanced atherosclerotic lesions compared to healthy vessels (P=.002 and .034). | 26764138 |
| Arteriosclerosis | Epigenetic Alterations | Histone acetylation and methylation seem to play a decisive role in atherosclerosis, showing significant differences between healthy vessels and vessels at different stages of atherosclerosis. | 26764138 |
| AMD1 wt Allele | Epigenetic Alterations | Our findings support the hypothesis that microRNA-mediated gene dysregulation may play a role in the pathogenesis of AMD. | 26765636 |
| Primary malignant neoplasm | Epigenetic Alterations | The target genes of these miRNAs were enriched in pathways of cancer and MAPK signaling. | 26766035 |
| PSD gene | Epigenetic Alterations | Blood miRNAs may be served as a potential biomarker for PSD diagnosis. | 26766035 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm. | 26767057 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Epigenetic modifications may play a relevant role in the pathogenesis of human abdominal aortic aneurysm (AAA). | 26767057 |
| Hemangioblastoma, CHEK2 gene | Epigenetic Alterations | Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis. | 26768750 |
| levamisole, Uterine Corpus Endometrial Stromal Sarcoma, Childhood Leiomyosarcoma | Epigenetic Alterations | To compare the microRNA (miRNA) profiles of uterine endometrial stromal sarcoma (ESS) and leiomyosarcoma (LMS), and to compare the miRNA signatures of primary and metastatic uterine LMS. | 26768834 |
| Leiomyosarcoma of uterus, Endometrial Stromal Sarcoma | Epigenetic Alterations | Uterine leiomyosarcoma and endometrial stromal sarcoma have unique miRNA signatures. | 26768834 |
| Malignant Neoplasms, levamisole | Epigenetic Alterations | Differential miRNA signatures of ESS and LMS provide novel data regarding transcriptional regulation in these cancers, based on which new potential diagnostic markers, prognostic biomarkers and therapeutic targets may be explored. | 26768834 |
| levamisole, Aggressive behavior | Epigenetic Alterations | Differences in miRNA profiles of primary and metastatic LMS may improve our understanding of disease progression in this aggressive malignancy. | 26768834 |
| levamisole | Epigenetic Alterations | Ninety-four miRNAs were significantly differentially expressed in ESS and LMS, of which 76 were overexpressed in ESS and 18 overexpressed in LMS. | 26768834 |
| levamisole | Epigenetic Alterations | Forty-nine miRNAs were differentially expressed in primary and metastatic LMS, of which 45 were overexpressed in primary LMS and 4 in metastases. | 26768834 |
| Leukemia, Myelomonocytic, Chronic | Epigenetic Alterations | Mutations involving epigenetic regulators (TET2~60% and ASXL1~40%) and splicing components (SRSF2~50%) are frequent in chronic myelomonocytic leukemia (CMML). | 26771811 |
| Intraductal Hyperplasia, Neoplasms, Fibroepithelial | Epigenetic Alterations | Genetic and epigenetic alterations in genes associated with distinct cellular pathways were checked in fibroepithelial tumors, including fibroadenomas, benign and malignant phyllode and atypical ductal hyperplasia. | 26774289 |
| Mammary Neoplasms | Epigenetic Alterations | Alterations (genetic/epigenetic) of the genes associated with Wnt signaling pathway were detected in 100% (20/20) of the breast tumors for at least one out of the six Wnt antagonists tested. | 26774289 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | The patterns of alterations, in particular the epigenetic alterations, differed little from that seen previously in breast carcinoma cells, suggesting epigenetic alterations to be an early event in the development of the tumors. | 26774289 |
| Carcinoma, Transitional Cell, Malignant Neoplasms | Epigenetic Alterations | MicroRNA-30a as a prognostic factor in urothelial carcinoma of bladder inhibits cellular malignancy by antagonising Notch1. | 26775686 |
| Hollings Cancer Center | Epigenetic Alterations | Both miRNA expression levels were lower in HCC liver biopsy specimens compared with normal liver RNA. | 26776075 |
| Chronic liver disease, Hollings Cancer Center | Epigenetic Alterations | Furthermore, expression of these miRNAs was compared between sera from chronic liver disease and sera from HCC patients. | 26776075 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia. | 26780610 |
| Neoplasms | Epigenetic Alterations | However, clonal tumor expansion from complex normal tissue architectures potentially obscures cancer-specific events, including divergent epigenetic patterns. | 26780610 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Epigenetic maturation in CLL was associated with an indolent gene expression pattern and increasingly favorable clinical outcomes. | 26780610 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Instead, we identified a potential pathogenic role for transcription factor dysregulation in CLL, where excess programming by EGR and NFAT with reduced EBF and AP-1 programming imbalances the normal B cell epigenetic program. | 26780610 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | TP53 and SOX2 were silenced using gene-specific siRNAs in human lung adenocarcinoma A427 cells, and the expression of TP53, SOX2 and subset of selected miRNAs was analyzed by qPCR. | 26780934 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Clearance of matrix metalloproteinase-9 is dependent on low-density lipoprotein receptor-related protein-1 expression downregulated by microRNA-205 in human abdominal aortic aneurysm. | 26781079 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | We hypothesized that LRP1 downregulation may be mediated by microRNA (miR) and that LRP1 may function as a scavenger of matrix metalloproteinase-9 (MMP-9), a well-known protease for degradation of extracellular matrix proteins at the aortic wall for AAA pathogenesis. | 26781079 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Long noncoding RNA HOTAIR is a prognostic biomarker and inhibits chemosensitivity to doxorubicin in bladder transitional cell carcinoma. | 26781446 |
| Lynch Syndrome | Epigenetic Alterations | At least one-third of patients meeting clinical criteria for Lynch syndrome will have no germline mutation and constitutional epimutations leading to promoter methylation of MLH1 have been identified in a subset of these patients. | 26781822 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-610 suppresses the proliferation of human glioblastoma cells by repressing CCND2 and AKT3. | 26782072 |
| Glioblastoma Multiforme | Epigenetic Alterations | However, the role of this microRNA in glioblastoma (GBM) is presently unclear. | 26782072 |
| Rheumatoid Arthritis | Epigenetic Alterations | Correlation Between the Expression of MicroRNA-301a-3p and the Proportion of Th17 Cells in Patients with Rheumatoid Arthritis. | 26782362 |
| Autoimmune Diseases | Epigenetic Alterations | MicroRNA (miR)-301a-3p is a regulatory factor for Th17 cells differentiation that contributes to the pathogenesis of autoimmune diseases. | 26782362 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Clinical significance of microRNA-34a in esophageal squamous cell carcinoma. | 26782413 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | MicroRNA-34a (miR-34a) has been found to be downregulated in esophageal squamous cell carcinoma (ESCC) tissues compared with that in normal tissues (P < 0.05), and miR-34a overexpression increased apoptosis and decreased clonogenic formation. | 26782413 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. | 26782462 |
| Schizophrenia | Epigenetic Alterations | Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue. | 26784971 |
| Neurodegenerative Disorders | Epigenetic Alterations | The DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set. | 26784972 |
| Neoplasms | Epigenetic Alterations | Solid tumors are characterized by a plethora of epigenetic changes. | 26785262 |
| Breast Cancer Cell | Epigenetic Alterations | Using pharmacological unmasking microarray, we identified promoter DNA methylation of cysteine dioxygenase 1 (CDO1) gene in human cancer. | 26785325 |
| Best Case Imputation Technique | Epigenetic Alterations | Prognostic relevance of the CDO1 promoter DNA methylation is worthy of being paid attention in triple negative BC cancer. | 26785325 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant DNA methylation pattern is a common feature of most cancers. | 26786290 |
| Stomach Carcinoma | Epigenetic Alterations | Gastric cancer (GC) is highly influenced by aberrant methylation, and accumulation of aberrant methylation in gastric mucosae produces an epigenetic field for cancerization. | 26792292 |
| Neoplasms | Epigenetic Alterations | Here, we aimed to demonstrate that FAT4, a novel tumor suppressor identified by exome sequencing of GC, is methylation-silenced and that such methylation is involved in epigenetic field cancerization for GC. | 26792292 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Accumulating evidence indicates that dysregulated microRNA-146a (miR-146a) is involved in tumour genesis and cancer progression. | 26794279 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | MicroRNA-146a expression level was significantly decreased in ESCC tissue compared with paracancerous tissue (P<0.001). | 26794279 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | MicroRNA-146a is significantly reduced in cancerous tissue and serum samples of ESCC patients. | 26794279 |
| Primary malignant neoplasm | Epigenetic Alterations | The methylation status was determined using Human Cancer miRNA EpiTect Methyl II Signature PCR Array(r) and the expression of miR-124, miR-218 and miR-193b was determined by qRT-PCR using individual TaqMan assays. | 26797462 |
| Carcinogenesis | Epigenetic Alterations | Abnormal expression and promoter methylation of microRNAs (miRNAs) are common events during cervical carcinogenesis. | 26797462 |
| Communicable Diseases, precancerous lesions, cervical cancer | Epigenetic Alterations | Methylation and expression of miRNAs in precancerous lesions and cervical cancer with HPV16 infection. | 26797462 |
| Communicable Diseases, cervical cancer | Epigenetic Alterations | In this study we analyzed the promoter methylation of 22 miRNAs and the expression of three miRNAs in 10 non-squamous intraepithelial lesions (Non-SIL) without HPV16 infection, and 7 Non-SIL, 16 low-grade SIL (LSIL) and 16 cervical cancer samples, all with HPV16 infection. | 26797462 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Overexpression of long non-coding RNA LOC400891 promotes tumor progression and poor prognosis in prostate cancer. | 26797783 |
| Malignancy-associated membranous nephropathy, Primary malignant neoplasm | Epigenetic Alterations | Several studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer biomarker has been identified to date. | 26798410 |
| melanoma, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | We analysed epigenome-wide DNA methylation profiles in 41 cancer discordant MZ twin-pairs with affected individuals diagnosed with tumours at different single primary sites: the breast, cervix, colon, endometrium, thyroid gland, skin (melanoma), ovary, and pancreas. | 26798410 |
| Carotid Artery Diseases | Epigenetic Alterations | Expression of Egfl7 and miRNA-126-5p in Symptomatic Carotid Artery Disease. | 26799121 |
| Cardiovascular Diseases | Epigenetic Alterations | Specific information about miRNA-126-5p and its expression in cardiovascular disease is scarce in comparison to that of miR-126-3p. | 26799121 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The authors previously demonstrated that 4 hypoxia-mediated microRNAs (miRNA)-miR-210, miR-21, miR-10b, and miR-196b-are upregulated in glioma as compared with normal brain tissue. | 26799295 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Dynamics of circulating hypoxia-mediated miRNAs and tumor response in patients with high-grade glioma treated with bevacizumab. | 26799295 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic Upregulation of Metallothionein 2A by Diallyl Trisulfide Enhances Chemosensitivity of Human Gastric Cancer Cells to Docetaxel Through Attenuating NF-kB Activation. | 26801633 |
| Crohn Disease | Epigenetic Alterations | MicroRNA-124 Promotes Intestinal Inflammation by Targeting Aryl Hydrocarbon Receptor in Crohns Disease. | 26802080 |
| Disease, Crohn Disease | Epigenetic Alterations | Dysregulation of microRNAs (miRNAs) is associated with a variety of diseases, including Crohns disease (CD), but the essential biological functions and crucial targets of miRNAs remain largely unknown. | 26802080 |
| Malignant Neoplasms | Epigenetic Alterations | Abnormal expression of microRNA-215 has been identified in a variety of solid cancers. | 26802165 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | However, little is known about the expression pattern of microRNA-215 in acute myeloid leukemia. | 26802165 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Compared with the healthy individuals, microRNA-215 expression in acute myeloid leukemia patients was significantly down-regulated (P= 0.001). | 26802165 |
| Non-M3 Acute Myeloid Leukemia | Epigenetic Alterations | MicroRNA-215 low-expressed patients had significantly shorter overall survival than microRNA-215 high-expressed patients in both non-M3 acute myeloid leukemia patients and cytogenetically normal patients (P= 0.017 and P= 0.044, respectively). | 26802165 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Our study demonstrates that reduced microRNA-215 expression is a common event and is associated with poor clinical outcome in acute myeloid leukemia. | 26802165 |
| Pelvic Organ Prolapse | Epigenetic Alterations | MicroRNA-92 expression may be associated with reduced estrogen receptor b1 mRNA levels in cervical portion of uterosacral ligaments in women with pelvic organ prolapse. | 26803387 |
| Alzheimers Disease | Epigenetic Alterations | Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimers disease. | 26803900 |
| Alzheimers Disease | Epigenetic Alterations | We have characterized changes in DNA methylation in the superior temporal gyrus of patients with Alzheimers disease, highlighting novel loci that facilitate better characterization of pathways and mechanisms underlying Alzheimers disease pathogenesis, and improve our understanding of epigenetic signatures that may contribute to the development of disease. | 26803900 |
| Alzheimers Disease | Epigenetic Alterations | Recent work has identified roles for environmental, genetic, and epigenetic factors in Alzheimers disease risk. | 26803900 |
| Breast Carcinoma | Epigenetic Alterations | Dysregulation of microRNA contributes to the high incidence and mortality of breast cancer. | 26806308 |
| Impaired cognition, Neuronal Plasticity | Epigenetic Alterations | Recently, it has been reported that the microRNA-132(miR-132) is linked with synaptic plasticity and cognitive impairment. | 26806865 |
| ETV3 wt Allele | Epigenetic Alterations | Our findings suggest that methylation in CPT1A is a promising epigenetic marker for MetS risk which could become useful as a treatment target in the future. | 26808626 |
| Malignant neoplasm of breast | Epigenetic Alterations | Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers. | 26810754 |
| Breast Carcinoma | Epigenetic Alterations | Quantitative real time PCR (qPCR) and immunoblotting were used to determine the impact of histone deacetylation and DNA methylation inhibitors on CREB3L1 expression in breast cancer cell lines. | 26810754 |
| Breast Carcinoma | Epigenetic Alterations | This study demonstrates that the low CREB3L1 expression previously seen in highly metastatic breast cancer cell lines is caused in part by epigenetic silencing. | 26810754 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | Our data further strengthens the role for CREB3L1 as a metastasis suppressor in breast cancer and demonstrates that epigenetic silencing is a major regulator of the loss of CREB3L1 expression. | 26810754 |
| Neoplasms | Epigenetic Alterations | However, there is a lack of information on how this epigenetic process differs in tumors originating at different sites in the stomach. | 26810771 |
| Aggressive behavior | Epigenetic Alterations | Mechanistic linkage of de-regulated miRNA/mRNA expressions provide new insights on their role in UM progression and aggressiveness. | 26812476 |
| Uveal melanoma | Epigenetic Alterations | Clinico-Pathological Association of Delineated miRNAs in Uveal Melanoma with Monosomy 3/Disomy 3 Chromosomal Aberrations. | 26812476 |
| Uveal melanoma | Epigenetic Alterations | To correlate the differentially expressed miRNAs with clinico-pathological features in uveal melanoma (UM) tumors harbouring chromosomal 3 aberrations among South Asian Indian cohort. | 26812476 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | miRNAs predicting liver metastasis and survival have been identified. | 26812476 |
| Malignant Neoplasms | Epigenetic Alterations | The SWI/SNF chromatin remodeling complex is frequently inactivated by somatic mutations of its various components in various types of cancers, and also by aberrant DNA methylation. | 26812616 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | These results showed that genetic and epigenetic alterations of the SWI/SNF complex are present in ESCCs, and suggested that genetic alterations are induced at an early stage of esophageal squamous cell carcinogenesis. | 26812616 |
| Malignant neoplasm of liver, Hepatitis C, Chronic | Epigenetic Alterations | Elevated serum microRNA-122/222 levels are potential diagnostic biomarkers in Egyptian patients with chronic hepatitis C but not hepatic cancer. | 26812693 |
| Hepatitis C, Malignant neoplasm of liver | Epigenetic Alterations | Using microarray-based expression profiling followed by real-time quantitative polymerase chain reaction validation, we compared the levels of circulating miRNA-122 and miRNA-222 in serum from patients with hepatitis C virus (n = 40) and liver cancer (n = 60) to matched healthy controls (n = 30). | 26812693 |
| Injury of liver, Hepatitis C, Malignant neoplasm of liver | Epigenetic Alterations | Because of their size, specificity, and relative stability in plasma, miRNAs can be used as diagnostic and prognostic biomarkers to monitor liver injury, such as that caused by hepatitis C virus (HCV) and liver cancer. | 26812693 |
| Injury of liver, Malignant neoplasm of liver | Epigenetic Alterations | Our results indicate that serum miR-122 and miR-222 are elevated in Egyptian patients with chronic HCV, and these miRNAs have a strong potential to serve as novel biomarkers for liver injury but not specifically for liver cancer. | 26812693 |
| Gallbladder Carcinoma | Epigenetic Alterations | Expression and mechanisms of long non-coding RNA genes MEG3 and ANRIL in gallbladder cancer. | 26812694 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Genomic loss of EZH2 leads to epigenetic modifications and overexpression of the HOX gene clusters in myelodysplastic syndrome. | 26812882 |
| SF3B1 wt Allele | Epigenetic Alterations | These findings suggest genomic loss of EZH2 contributes to overexpression of the HOX gene clusters in MDS through epigenetic modifications. | 26812882 |
| Malignant Neoplasms | Epigenetic Alterations | Single nucleotide polymorphisms (SNPs) within microRNAs (miRNAs) are considered potential markers for risk and prognosis of various cancers. | 26815502 |
| Asthma Pathway | Epigenetic Alterations | Severe asthma AMs also expressed increased levels of three microRNAs, which we showed were able to directly reduce TLR7 expression. | 26815632 |
| Hollings Cancer Center | Epigenetic Alterations | Here, we seek a more in-depth understanding of the roles of miRNAs and their targets in HCC by integrating the miRNA and messenger RNA (mRNA) expression profiles of tumorous and adjacent non-tumorous liver tissues of 100 HCC patients. | 26817861 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | To date, studies of the roles of microRNAs (miRNAs) in hepatocellular carcinoma (HCC) have either focused on specific individual miRNAs and a small number of suspected targets or simply reported a list of differentially expressed miRNAs based on expression profiling. | 26817861 |
| Liver carcinoma | Epigenetic Alterations | Differentially Expressed miRNAs in Hepatocellular Carcinoma Target Genes in the Genetic Information Processing and Metabolism Pathways. | 26817861 |
| Hollings Cancer Center | Epigenetic Alterations | Three of these miRNAs (miR-26a, miR-122, and miR-130a) were down-regulated in HCC, and their up-regulated gene targets are primarily associated with aberrant cell proliferation that involves DNA replication, transcription and nucleotide metabolism. | 26817861 |
| Hollings Cancer Center | Epigenetic Alterations | The other three miRNAs (miR-21, miR-93, and miR-221) were up-regulated in HCC, and their down-regulated gene targets are primarily involved in metabolism and immune system processes. | 26817861 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Association between early promoter-specific DNA methylation changes and outcome in older acute myeloid leukemia patients. | 26818573 |
| ibudilast | Epigenetic Alterations | The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of IBD. | 26818663 |
| Neoplasms | Epigenetic Alterations | Among them, microRNAs (miRNA),identified as negative (post-transcriptional) gene expression regulators involved in tumor development, are likely to discriminate among FNs. | 26818914 |
| Follicular neoplasm | Epigenetic Alterations | The evaluation of miRNAs on thyroid FNAC: the promising role of miR-375 in follicular neoplasms. | 26818914 |
| AKAP13 wt Allele | Epigenetic Alterations | LBC is suitable for miRNAs evaluation. | 26818914 |
| Malignant Neoplasms, Colorectal Cancer Pathway, Clinical Coordinator, Neoplasms | Epigenetic Alterations | Accumulating evidence showed that microRNA-152 (miR-152) was frequently downregulated, and functioned as tumor suppressor in many cancers, but little is known about its biological role and intrinsic regulatory mechanisms in colorectal cancer (CRC). | 26820128 |
| Breast Carcinoma | Epigenetic Alterations | A novel long non-coding RNA FGF14-AS2 is correlated with progression and prognosis in breast cancer. | 26820525 |
| Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have been found to be pervasively transcribed in the genome and played critical roles in cancer progression. | 26820525 |
| Hashimoto Disease | Epigenetic Alterations | Increases of microRNA let-7e in peripheral blood mononuclear cells in Hashimotos disease. | 26821743 |
| Prostate | Epigenetic Alterations | The three variants are located within or near a number of prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2. | 26823525 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Epigenetic associations of type 2 diabetes and BMI in an Arab population. | 26823690 |
| Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, Neoplasms | Epigenetic Alterations | microRNAs (miRNAs) play essential roles in many tumors, including renal cell carcinoma (RCC). | 26823729 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | MDR1 gene could be activated via epigenetic mechanisms with demethylation of Line-1 in ESCC, and enhance tumor progression. | 26823755 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in many important cellular processes and deregulation of miRNAs is linked to many human diseases including cancer. | 26823812 |
| Cervix Diseases | Epigenetic Alterations | The current results indicated that MS-HRM-based testing for DNA methylations of MGMT plus DAPK1 genes holds some promise for high grade cervical disease screening. | 26823825 |
| Neoplasms | Epigenetic Alterations | DNA methylation has been recently recognized as a novel tumor marker. | 26823831 |
| Intestinal metaplasia, Dysplasia, Stomach Carcinoma, Gastritis, Atrophic | Epigenetic Alterations | A total of 180 tissue and plasma samples (including 50 cases of gastric cancer, 50 dysplasia, 50 chronic atrophic gastritis with intestinal metaplasia and 30 normal controls) were collected for detecting DNA methylation status of Reprimo and hMLH1 genes using MSP method. | 26823831 |
| Stomach Carcinoma, Dysplasia, Gastritis | Epigenetic Alterations | The positive rate of DNA methylation rate was, in ascending sequence, gastritis tissue, dysplasia tissue and gastric carcinoma tissue. | 26823831 |
| Depressed mood, Stomach Carcinoma, RPRM gene | Epigenetic Alterations | The DNA methylation occurred in promoter regions of both Reprimo and hMLH1 genes depressed the protein expression, and may participate in the occurrence and progression and gastric cancer. | 26823831 |
| Stomach Carcinoma | Epigenetic Alterations | The combined assay of serum Reprimo and hMLH1 DNA methylation levels thus had critical importance in the early diagnosis and gastric cancer. | 26823831 |
| Metastasis | Epigenetic Alterations | Down-regulation of microRNA-126 and microRNA-133b acts as novel predictor biomarkers in progression and metastasis of non small cell lung cancer. | 26823832 |
| Primary malignant neoplasm | Epigenetic Alterations | MiRNAs play crucial roles in progression of cancer. | 26823832 |
| Stomach Carcinoma | Epigenetic Alterations | Correlation between microRNA-421 expression level and prognosis of gastric cancer. | 26823855 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | The expression of microRNA-421 (miR-421) is significantly elevated in gastric carcinoma cells, thus may play an important role in tumor occurrence. | 26823855 |
| Diabetes Mellitus | Epigenetic Alterations | Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes. | 26825526 |
| Diabetes Mellitus | Epigenetic Alterations | Tobacco smoking, a risk factor for diabetes, is an established modifier of DNA methylation. | 26825526 |
| Diabetes Mellitus | Epigenetic Alterations | We hypothesised that tobacco smoking modifies DNA methylation of genes previously identified for diabetes. | 26825526 |
| Diabetes Mellitus | Epigenetic Alterations | Tobacco smoking is associated with differential DNA methylation of the diabetes risk genes ANPEP, KCNQ1 and ZMIZ1. | 26825526 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | We performed a high-throughput microarray to detect the ncRNA expression profiles of 220 human glioma tissues. | 26828136 |
| Malignant Neoplasms, melanoma | Epigenetic Alterations | Their expression profiles are frequently dysregulated in cancers; hence, levels of serum microRNAs may reflect progression status and thus predict melanoma prognosis. | 26829037 |
| Discordance | Epigenetic Alterations | We conclude that prenatal conditions for birth-weight discordance may result in persistent epigenetic modifications potentially affecting even adult health. | 26831219 |
| Prostatic Hyperplasia, Tetranitromethane, Prostate Cancer Pathway | Epigenetic Alterations | Differential blood-based diagnosis between benign prostatic hyperplasia and prostate cancer: miRNA as source for biomarkers independent of PSA level, Gleason score, or TNM status. | 26831660 |
| Prostate Cancer Pathway | Epigenetic Alterations | There is evidence that microRNAs (miRNAs) in whole peripheral blood can separate patients with localized prostate cancer from healthy individuals. | 26831660 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | By microarray approach, we identified seven miRNAs that were significantly deregulated in PCa patients compared to BPH patients. | 26831660 |
| Tetranitromethane | Epigenetic Alterations | Clinical parameters like PSA level, Gleason score, or TNM status seem to have only limited impact on the overall abundance of miRNAs in patients blood, suggesting a no influence of these factors on the expression of deregulated miRNAs. | 26831660 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | DNA methylation status defines clinicopathological parameters including survival for patients with clear cell renal cell carcinoma (ccRCC). | 26831665 |
| Neoplasms | Epigenetic Alterations | DNA methylation classification of ccRCC tumor samples at diagnosis can serve as a clinically applicable prognostic marker in ccRCC. | 26831665 |
| Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, Neoplasms | Epigenetic Alterations | Epigenetic alterations in the methylome have been associated with tumor development and progression in renal cell carcinoma (RCC). | 26831665 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | MicroRNA-7 downregulates the oncogene VDAC1 to influence hepatocellular carcinoma proliferation and metastasis. | 26831666 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Aberrant DNA methylation status of some genes has been shown to be involved in chemoresistance of acute myeloid leukemia (AML). | 26835708 |
| malignant disease, Stomach Carcinoma | Epigenetic Alterations | Gastric cancer (GC) is a common malignant disease and microRNAs (miRNAs) have been shown to play important roles in GC tumorigenesis. | 26835790 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Our results suggest that MIR17HG gene expression is dysregulated in gastric cancer in which it may indicate a tumor suppressive function of this miRNA cluster host gene in gastric cancer. | 26837962 |
| Relapsing course, Childhood Leukemia | Epigenetic Alterations | Impact of Global and Gene-Specific DNA Methylation in de Novo or Relapsed Acute Myeloid Leukemia Patients Treated with Decitabine. | 26838251 |
| Degenerative polyarthritis, Right arm | Epigenetic Alterations | We compared microRNA (miR) expression in CD14(+) cells from patients with active RA or with osteoarthritis (OA). | 26838552 |
| Neoplasms | Epigenetic Alterations | microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. | 26840028 |
| Neoplasms | Epigenetic Alterations | In summary, our results reveal that miR-1827 is a novel miRNA that regulates p53 through targeting MDM2, and highlight an important role and the underlying mechanism of miR-1827 in tumor suppression. | 26840028 |
| Carcinoma of lung | Epigenetic Alterations | A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer. | 26842235 |
| Primary malignant neoplasm | Epigenetic Alterations | We aimed to identify epigenetic biomarkers with clinical utility for cancer diagnosis in minimally/noninvasive specimens to improve accuracy of current technologies. | 26842235 |
| Lung Neoplasms | Epigenetic Alterations | The identification of novel epigenetic biomarkers in stage I lung tumors was accomplished using an integrative genome-wide restrictive analysis of two different large public databases. | 26842235 |
| Primary malignant neoplasm | Epigenetic Alterations | Calibrated and cross-validated epigenetic model predicts with high accuracy the probability to detect cancer in minimally and noninvasive samples. | 26842235 |
| Carcinoma of lung | Epigenetic Alterations | We demonstrated that this epigenetic signature achieved higher diagnostic efficacy in bronchial fluids as compared with conventional cytology for lung cancer diagnosis. | 26842235 |
| Primary malignant neoplasm | Epigenetic Alterations | Minimally invasive epigenetic biomarkers have emerged as promising tools for cancer diagnosis. | 26842235 |
| Carcinoma of lung | Epigenetic Alterations | The herein obtained epigenetic model in combination with current diagnostic protocols may improve early diagnosis and outcome of lung cancer patients. | 26842235 |
| Acute Coronary Syndrome | Epigenetic Alterations | Association between microRNA-21 concentration and lipid profile in patients with acute coronary syndrome without persistent ST-segment elevation. | 26842377 |
| Secondary malignant neoplasm of liver, Colorectal Carcinoma, Neoplasms | Epigenetic Alterations | MiRNA-21 Expression Decreases from Primary Tumors to Liver Metastases in Colorectal Carcinoma. | 26845148 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway | Epigenetic Alterations | We analyzed the expression of miRNA-21, miRNA-31 and miRNA-373 in corresponding formalin-fixed paraffin-embedded (FFPE) tissue samples of primary colorectal cancer, liver metastasis and healthy tissues of 29 patients by quantitative real-time PCR. | 26845148 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | MiRNA-21 and miRNA-31 were also higher expressed in liver metastases as compared to healthy liver tissues (p < 0.01). | 26845148 |
| Primary Neoplasm | Epigenetic Alterations | No significant difference of expression of miRNA-31 and miRNA-373 was observed between primary tumors and metastases. | 26845148 |
| Secondary malignant neoplasm of liver, Colorectal Neoplasms | Epigenetic Alterations | Of note, miRNA-21 expression was significantly reduced in liver metastases as compared to the primary colorectal tumors (p < 0.01). | 26845148 |
| Colorectal Cancer Pathway, Metastasis, Neoplasms | Epigenetic Alterations | Expression of certain miRNAs in the primary tumors has been shown to be associated with progression of colorectal cancer and the initiation of metastasis. | 26845148 |
| Neoplasms | Epigenetic Alterations | All three miRNAs were significantly up-regulated in the primary tumor tissues as compared to healthy colon mucosa of the respective patients (p < 0.01). | 26845148 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Identification of microRNA expression profile related to lymph node status in women with early-stage grade 1-2 endometrial cancer. | 26847173 |
| Neoplasms | Epigenetic Alterations | microRNA expression was assessed in nine formalin-fixed paraffin-embedded (FFPE) EC primary tumors with positive lymph node and in 27 FFPE EC primary tumors with negative lymph node, matched for grade, stage, and lymphovascular space involvement status. | 26847173 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | microRNA-137 (miR-137) has been reported as a tumor suppressor in various types of cancer. | 26847706 |
| Neoplasms | Epigenetic Alterations | Recently, long non-coding RNAs (lncRNAs), which are non-protein coding transcripts longer than 200 nucleotides, have emerged as a key aspect in tumor pathogenesis. | 26847923 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small noncoding RNAs, which have been implicated in most human cancers due to their role in post transcriptional gene regulation. | 26848861 |
| SF3B1 wt Allele, Neoplasms | Epigenetic Alterations | Our data indicate that spliceosome mutations may play an important role in MDS pathophysiology by affecting the expression of tumor suppressor miRNA genes involved in the development and progression of MDS. | 26848861 |
| Neoplasms, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations. | 26848861 |
| SF3B1 wt Allele | Epigenetic Alterations | The majority of the studied miRNAs have previously been implicated in MDS. | 26848861 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Finally, we observed that the predicted targets of the most downregulated miRNAs were involved in apoptosis, hematopoiesis, and acute myeloid leukemia among other cancer- and metabolic pathways. | 26848861 |
| Primary malignant neoplasm | Epigenetic Alterations | Enhancer of zeste homolog 2 (EZH2) is an essential component of the polycomb repressive complex 2 (PRC2), which is required for epigenetic silencing of target genes, including those affecting cancer progression. | 26848980 |
| Metastasis, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | RIP and ChIP assays suggest that EZH2 is recruited to the E-cadherin promoter by the long non-coding RNA, MALAT-1 (metastasis associated in lung adenocarcinoma transcript 1), where it represses E-cadherin expression. | 26848980 |
| Leukemia, T-Cell | Epigenetic Alterations | Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients. | 26849145 |
| Feel Pain | Epigenetic Alterations | Correlation Between DNA Methylation of TRPA1 and Chronic Pain States in Human Whole Blood Cells. | 26849948 |
| Feel Pain | Epigenetic Alterations | The presence of a burning sensation, which is one of pain symptoms in the DN4 questionnaire, was significantly correlated with the increase in DNA methylation level of TRPA1. | 26849948 |
| Chronic pain, Feel Pain | Epigenetic Alterations | TRPA1 DNA methylation levels in whole blood cells appear to be associated with pain symptoms in chronic pain patients. | 26849948 |
| Hypoxia | Epigenetic Alterations | microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. | 26851030 |
| Malignant neoplasm of cardioesophageal junction of stomach | Epigenetic Alterations | Hypoxia-regulated MicroRNAs in Gastroesophageal Cancer. | 26851030 |
| Stomach Carcinoma, Metastasis, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs), a critical part of epigenetic regulations in tumor, have been shown to be closely related to the initiation, development, invasion, metastasis and prognosis of gastric cancer. | 26851540 |
| Liver Cirrhosis | Epigenetic Alterations | HSA undergoes spontaneous structural modifications, mainly by reaction with oxidants and saccharides; however, patients with cirrhosis show extensive post-transcriptional changes at several molecular sites of HSA, the degree of which parallels the severity of the disease. | 26852162 |
| Disease | Epigenetic Alterations | MicroRNAs play important roles in the development and progression of many human diseases. | 26852168 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Gastric cancer (GC) is the third most common cancer in India and is mediated by multiple genetic, epigenetic and environmental risk factors. | 26853425 |
| cervical cancer metastasis | Epigenetic Alterations | Human MALAT-1 long non-coding RNA is overexpressed in cervical cancer metastasis and promotes cell proliferation, invasion and migration. | 26854446 |
| Malignant Neoplasms, Metastasis, Adenocarcinoma of lung (disorder), Neoplasms | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been shown to play a crucial role in the development as well as the prognosis of various human cancers, particularly in human metastasis associated lung adenocarcinoma transcript-1 (MALAT-1), which has been shown to be upregulated in some tumors. | 26854446 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | We conclude that miRNAs, in particular miR-34a, may have clinical utility in DLBCL patients as both predictive and prognostic biomarkers. | 26854484 |
| Malignant Neoplasms, melanoma, Neoplasms | Epigenetic Alterations | Structural compromise of the tumor suppressor gene, phosphatase and tensin homolog (PTEN), occurs in 10% of melanoma specimens, and loss of PTEN expression through DNA methylation of the PTEN promoter region has also been reported in a number of other malignancies. | 26854490 |
| Diabetes Mellitus, Insulin-Dependent | Epigenetic Alterations | DNA methylation and mRNA expression of HLA-DQA1 alleles in type 1 diabetes mellitus. | 26854762 |
| Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Epigenetic Alterations | Methylation profile observed in patients with T1D and healthy controls was similar, and no correlation between HLA-DQA1 allele expression and DNA methylation was found. | 26854762 |
| Admitting diagnosis | Epigenetic Alterations | miR-603, a novel primate-specific miRNA and an intronic miRNA of a human brain highly expressed gene KIAA1217, is implicated in the risk and pathogenesis of AD. | 26856603 |
| Admitting diagnosis | Epigenetic Alterations | This work suggests that miR-603 may be a novel AD-relevant miRNA and that its rs11014002 SNP may serve as a protective factor against AD. | 26856603 |
| Sjogrens Syndrome", Autoimmune Diseases, Perceived stress scale | Epigenetic Alterations | Increasing evidence suggests an epigenetic contribution to the pathogenesis of autoimmune diseases, including primary Sjogrens Syndrome (pSS). | 26857698 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | MicroRNA-194 is a Marker for Good Prognosis in Clear Cell Renal Cell Carcinoma. | 26860079 |
| Aneuploidy | Epigenetic Alterations | We conclude that the aneuploidy and senescence paradoxes can be explained by the mutual platform of polyploidy, conferring genomic and epigenetic instability as a survival advantage. | 26860864 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Inhibiting malignant phenotypes of the bladder cancer cells by silencing long noncoding RNA SChLAP1. | 26861061 |
| Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) play key roles in process of cancer cell growth and apoptosis and have received increasing attention. | 26861061 |
| Experimental Organism Basal Cell Carcinoma | Epigenetic Alterations | Long-noncoding RNAs in basal cell carcinoma. | 26861560 |
| Metastasis | Epigenetic Alterations | MicroRNA-130b promotes proliferation and EMT-induced metastasis via PTEN/p-AKT/HIF-1a signaling. | 26861561 |
| Neoplasm Metastasis | Epigenetic Alterations | miR-130b is one of several miRNAs involved in tumor metastasis. | 26861561 |
| Degenerative polyarthritis | Epigenetic Alterations | Overexpression of microRNA-210 promotes chondrocyte proliferation and extracellular matrix deposition by targeting HIF-3a in osteoarthritis. | 26861791 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer. | 26863570 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | The contribution of long noncoding RNAs (lncRNAs) to metastasis of gastric cancer remains largely unknown. | 26863570 |
| Transitional cell carcinoma of ureter | Epigenetic Alterations | Urothelial cancer associated 1 (UCA1) is an example of functional long noncoding RNAs involved in many biologic processes. | 26867765 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNA (lncRNA) HOX antisense intergenic RNA (HOTAIR) has recently emerged as a key molecule in many cancers, triggering epithelial-mesenchymal transition (EMT)-mediated cancer stem cell (CSC) formation, but little is known about its significance in EC. | 26868332 |
| Carcinoma of lung | Epigenetic Alterations | Integrative microRNA and gene profiling data analysis reveals novel biomarkers and mechanisms for lung cancer. | 26870998 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Studies on the accuracy of microRNAs (miRNAs) in diagnosing non-small cell lung cancer (NSCLC) have still controversial. | 26870998 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Therefore, we conduct to systematically identify miRNAs related to NSCLC, and their target genes expression changes using microarray data sets. | 26870998 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We screened out five miRNAs and six genes microarray data sets that contained miRNAs and genes expression in NSCLC from Gene Expression Omnibus. | 26870998 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our analysis results indicated that fourteen miRNAs were significantly dysregulated in NSCLC. | 26870998 |
| selenium | Epigenetic Alterations | We also found that 4 target genes (p < 0.05, fold change > 2.0) were significant correlation with the 14 discovered miRNAs, and the classifiers we built from one training set predicted the validation set with higher accuracy (SE = 0.987, SP = 0.824). | 26870998 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our results demonstrate that integrating miRNAs and target genes are valuable for identifying promising biomarkers, and provided a new insight on underlying mechanism of NSCLC. | 26870998 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Further, our well-designed validation studies surely warrant the investigation of the role of target genes related to these 14 miRNAs in the prediction and development of NSCLC. | 26870998 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway. | 26871294 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-31 (miR-31) plays an oncogenic role and is associated with BRAF mutation and poor prognosis in colorectal cancer. | 26871294 |
| melanoma | Epigenetic Alterations | A number of common driver mutations have been identified in melanoma, but other genetic or epigenetic aberrations are also likely to play a role in the pathogenesis of melanoma and present potential therapeutic targets. | 26872010 |
| Primary malignant neoplasm | Epigenetic Alterations | More recently, it has been found that TGF-b1 acts through microRNAs to regulate their target genes to promote cancer progresses. | 26873488 |
| Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | Unique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease. | 26875698 |
| Hepatocarcinogenesis | Epigenetic Alterations | Patients with high serum AFP and high degree of ballooning showed accumulation of oxidative DNA damage that could be a seed of DNA methylation responsible for hepatocarcinogenesis. | 26875698 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | Previously, we reported that DNA oxidation induced epigenetic alteration of tumor suppressor genes (TSGs) and contributed to HCC emergence. | 26875698 |
| Acute myocardial infarction | Epigenetic Alterations | Plasma microRNA-21 is a potential diagnostic biomarker of acute myocardial infarction. | 26875904 |
| liposarcoma | Epigenetic Alterations | In addition, a tight linear progression of miRNA expression was identified from normal fat to dedifferentiated liposarcoma. | 26878133 |
| Sarcoma - category (morphologic abnormality) | Epigenetic Alterations | These results suggest that miRNA expression profiles could elucidate classes of miRNAs that may elicit tumor-relevant activities in specific sarcoma subtypes. | 26878133 |
| Sarcoma | Epigenetic Alterations | A selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas. | 26878133 |
| liposarcoma, synovial sarcoma, Neoplasms | Epigenetic Alterations | Unexpectedly, we found that a set of muscle-specific microRNAs (miRNAs; myomiRs): miR-133, miR-1, and miR-206 was significantly underexpressed in well-differentiated liposarcoma and synovial sarcoma, suggesting that they may function as tumor suppressors as described in muscle-relevant rhabdomyosarcomas. | 26878133 |
| Malignant Neoplasms, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Recently, we have demonstrated that PIK3CA mutation and the methylation level of long interspersed nucleotide element 1 (LINE-1) (a surrogate marker of global DNA methylation level) are prognostic markers and have crucial role on malignancy in ESCC patients. | 26880326 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer. | 26882562 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | To identify microRNAs (miRNAs) that regulate HNSCC invasion, we compared miRNA expression profiles between a parent HNSCC cell line and a highly invasive clone. | 26882562 |
| Liver carcinoma | Epigenetic Alterations | Genome-wide DNA methylation analysis in hepatocellular carcinoma. | 26883180 |
| Hollings Cancer Center | Epigenetic Alterations | Our results suggest that epigenetic silencing of these genes may be associated with HCC. | 26883180 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Long noncoding RNA ENST00000434223 suppressed tumor progression in non-small cell lung cancer. | 26883250 |
| Primary malignant neoplasm | Epigenetic Alterations | Emerging evidence has demonstrated the vital roles of long noncoding RNAs (lncRNAs) in cancer development. | 26883250 |
| Tuberculosis, Multidrug-Resistant | Epigenetic Alterations | A total of 50 differentially expressed proteins and 43 differentially expressed miRNAs (fold change >1.50 or <0.60, P<0.05) were identified in the MDR-TB patients compared to both DS-TB patients and healthy controls. | 26884721 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation and hormone receptor status in breast cancer. | 26884818 |
| Primary malignant neoplasm | Epigenetic Alterations | Clinical Impact of a Novel MicroRNA Chemo-Sensitivity Predictor in Gastrooesophageal Cancer. | 26885979 |
| Gastrooesophageal cancer | Epigenetic Alterations | The miRNA profile predictive for sensitivity to cisplatin, epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer. | 26885979 |
| Adrenal gland hypofunction | Epigenetic Alterations | Hypofunctionality of NK cells was associated with impaired STAT4 phosphorylation and downregulation of the STAT4 target microRNA-155. | 26887815 |
| Sleep Apnea, Obstructive | Epigenetic Alterations | Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype. | 26888452 |
| OSA protein, Drosophila, Hypertensive disease, daytime sleepiness, Sleep Apnea, Obstructive, Ehlers-Danlos Syndrome | Epigenetic Alterations | We hypothesized that DNA methylation patterns may contribute to disease severity or the development of hypertension and excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA). | 26888452 |
| OSA protein, Drosophila | Epigenetic Alterations | In the validation cohort, no significant difference in DNA methylation levels of six selected genes was found between the primary snoring subjects and OSA patients (primary outcome). | 26888452 |
| Sjogrens Syndrome | Epigenetic Alterations | Autoantigen-targeting microRNAs in Sjogrens syndrome. | 26888739 |
| Sjogrens Syndrome | Epigenetic Alterations | This, on the one hand, characterized two autoantigen-targeting microRNAs in Sjogrens syndrome and, on the other hand, suggested that downregulation of miR-1207-5p and miR-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjogrens syndrome. | 26888739 |
| CHOANAL ATRESIA, POSTERIOR, charmed | Epigenetic Alterations | We conclude that whole-genome methylation profiling with CHARM revealed distinct patterns of differential DNA methylation between normal prostate and PCa tissues, as well as between different risk groups of PCa as defined by Gleason scores. | 26890304 |
| Juvenile Myelomonocytic Leukemia | Epigenetic Alterations | Methylation of a reporter construct containing this region resulted in strong suppression of AKAP12 promoter activity, suggesting that DNA methylation might be involved in the aberrant silencing of the AKAP12 promoter in JMML. | 26891149 |
| Juvenile Myelomonocytic Leukemia | Epigenetic Alterations | Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia. | 26891149 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic silencing of AKAP12 has been demonstrated in different cancer entities and this has been linked to the process of tumorigenesis. | 26891149 |
| Juvenile Myelomonocytic Leukemia | Epigenetic Alterations | Together, these data provide evidence for epigenetic silencing of AKAP12a in JMML and further emphasize the importance of dysregulated RAS signaling in JMML pathogenesis. | 26891149 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | MicroRNAs (miRNAs) play vital roles in cell proliferation, differentiation and apoptosis in hepatocellular carcinoma (HCC). | 26891666 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | A genetic variation in microRNA target site of ETS2 is associated with clinical outcomes of paclitaxel-cisplatin chemotherapy in non-small cell lung cancer. | 26893365 |
| Glioma | Epigenetic Alterations | HULC long noncoding RNA silencing suppresses angiogenesis by regulating ESM-1 via the PI3K/Akt/mTOR signaling pathway in human gliomas. | 26894862 |
| Malignant neoplasm of liver, Glioma | Epigenetic Alterations | Highly upregulated in liver cancer (HULC) is a long noncoding RNA (lncRNA) that acts as an oncogene in gliomas. | 26894862 |
| Malignant Neoplasms | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) are associated with the development, progression, and prognosis of human cancers. | 26895099 |
| Malignant Neoplasms | Epigenetic Alterations | Micro RNA (miR)-486-5p is often aberrantly expressed in human cancers. | 26895105 |
| Carcinogenesis | Epigenetic Alterations | Choline and betaine are important for DNA methylation and synthesis, and may affect tumor carcinogenesis. | 26897124 |
| Breast Carcinoma, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Roles of microRNA-124a and microRNA-30d in breast cancer patients with type 2 diabetes mellitus. | 26897751 |
| Congenital Abnormality | Epigenetic Alterations | Mutations of the epigenetic genes KMT2D and KDM6A cause dysregulation of certain developmental genes and account for the multiple congenital anomalies of the syndrome. | 26898171 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | microRNA-210 (miR-210), the master hypoxamir, is overexpressed and generally exhibits oncogenic properties in most human solid tumours, including colorectal cancer (CRC). | 26898324 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Myelodysplastic syndromes (MDS) are driven by complex genetic and epigenetic alterations. | 26898884 |
| Malignant neoplasm of stomach stage IV | Epigenetic Alterations | hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a. | 26903137 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in the pathogenesis of ovarian cancer. | 26908019 |
| Primary malignant neoplasm | Epigenetic Alterations | Long Noncoding RNA PVT1 Promotes Non-Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS2 Expression. | 26908628 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (lncRNA) are a novel class of transcripts with no protein coding capacity, but with diverse functions in cancer cell proliferation, apoptosis, and metastasis. | 26908628 |
| Metastasis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Expression levels of microRNA-145 and microRNA-10b are associated with metastasis in non-small cell lung cancer. | 26909466 |
| Metastasis, Neoplasms | Epigenetic Alterations | Accumulating evidence suggests that microRNAs (miRNAs) are key players in the regulation of tumor cell invasion and metastasis. | 26909466 |
| Metastasis, Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Expression of miR-9, miR-10b, miR-145, and miR-155, 4 miRNAs previously shown to play roles in metastasis in other tumor types, was compared in lymph node (LN)-positive NSCLC versus LN-negative NSCLC. | 26909466 |
| Coronary Artery Disease | Epigenetic Alterations | Recent studies have suggested that single-nucleotide polymorphisms (SNPs) in miRNA genes or their binding sites may alter an individuals susceptibility to coronary artery disease (CAD). | 26909569 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) act as key regulators of multiple cancers. | 26909600 |
| Primary malignant neoplasm | Epigenetic Alterations | The long non-coding RNA MALAT-1 plays an important role in cancer prognosis. | 26909935 |
| Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | These findings suggest RUNX1high is a prognostic biomarker of unfavorable outcome in CN-AML, which is supported by the distinctive gene/microRNA signatures and cell signaling pathways. | 26910834 |
| Cytogenetically normal acute myeloid leukemia | Epigenetic Alterations | Several known oncogenes/oncogenic microRNAs and cell signaling pathways were all up-regulated, while some anti-oncogenes and molecules of immune activation were down-regulated in RUNX1high CN-AML patients. | 26910834 |
| Malignant Neoplasms | Epigenetic Alterations | As an area of focus in the post-genome period, long non-coding RNAs (lncRNAs) have been found to play critical roles in many cancers, including TNBC. | 26910840 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-410 acts as oncogene in NSCLC through downregulating SLC34A2 via activating Wnt/b-catenin pathway. | 26910912 |
| Gastric Adenocarcinoma | Epigenetic Alterations | Enhanced expression of long non-coding RNA NEAT1 is associated with the progression of gastric adenocarcinomas. | 26911892 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer. | 26911892 |
| Stomach Carcinoma | Epigenetic Alterations | Increased expression of long noncoding RNA TUG1 predicts a poor prognosis of gastric cancer and regulates cell proliferation by epigenetically silencing of p57. | 26913601 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent evidence highlights long noncoding RNAs (lncRNAs) as crucial regulators of cancer biology that contribute to tumorigenesis. | 26913601 |
| Inflammatory Breast Carcinoma | Epigenetic Alterations | MicroRNA expression profiling identifies decreased expression of miR-205 in inflammatory breast cancer. | 26916073 |
| Rectal Neoplasms | Epigenetic Alterations | A small-scale immunohistochemistry analysis showed coexistence of decreased microRNA-205 expression and decreased E-cadherin expression in some ductal tumors. | 26916073 |
| Breast Carcinoma, Inflammatory Breast Carcinoma | Epigenetic Alterations | MicroRNA-205 may serve as a therapeutic target in advanced breast cancer including inflammatory breast cancer. | 26916073 |
| Neoplasms | Epigenetic Alterations | Although many microRNAs were differentially expressed between normal breast tissue and tumor tissue, most of them did not show differential expression between inflammatory and noninflammatory tumor samples. | 26916073 |
| melanoma | Epigenetic Alterations | microRNA in situ hybridization for miR-211 detection as an ancillary test in melanoma diagnosis. | 26916074 |
| melanoma | Epigenetic Alterations | These results support miR-211 as a leading miRNA candidate for melanoma diagnosis and miRNA in situ hybridization as a uniquely uncomplicated ancillary test. | 26916074 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Recent advantages of serum miRNAs open a new realm of possibilities for non-invasive diagnosis and prognosis of bladder cancer (BC). | 26916216 |
| Glioblastoma Multiforme | Epigenetic Alterations | Decreased miRNA-146a in glioblastoma multiforme and regulation of cell proliferation and apoptosis by target Notch1. | 26916895 |
| Hypertensive (finding), Heart Diseases | Epigenetic Alterations | Effect of Renal Sympathetic Denervation on Specific MicroRNAs as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease. | 26916982 |
| Septicemia, Russell-Silver syndrome | Epigenetic Alterations | Sepsis eQTL were enriched in endotoxin-induced epigenetic marks and modulated the individual host response to sepsis, including effects specific to SRS group. | 26917434 |
| T-Cell Prolymphocytic Leukemia | Epigenetic Alterations | Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia. | 26917488 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | We aimed to identify early-phase circulating microRNAs after liver transplantation for predicting tumor recurrence and survival of HCC recipients. | 26918346 |
| Hollings Cancer Center | Epigenetic Alterations | Candidate microRNAs were validated in 62 HCC recipients by quantitative RT-PCR. | 26918346 |
| Neoplasms | Epigenetic Alterations | The prognostic values of microRNAs for tumor recurrence and survival were examined. | 26918346 |
| Reperfusion Injury | Epigenetic Alterations | Simulated in vitro ischemia-reperfusion injury models were employed to characterize the possible mechanism of up-regulation of circulating microRNAs. | 26918346 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | Early-phase circulating miRNAs predict tumor recurrence and survival of hepatocellular carcinoma patients after liver transplantation. | 26918346 |
| Glioma | Epigenetic Alterations | The Potential Prognostic Value of MicroRNA-429 for Human Gliomas. | 26927341 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-429 (miR-429) is reported to be frequently dysregulated in cancer. | 26927341 |
| Diabetic Nephropathy | Epigenetic Alterations | MicroRNAs (miRNAs) are short non-coding RNA species which are important post-transcriptional regulators of gene expression and play an important role in the pathogenesis of diabetic nephropathy. | 26930277 |
| Diabetic Nephropathy | Epigenetic Alterations | Urinary Exosomal miRNA Signature in Type II Diabetic Nephropathy Patients. | 26930277 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | In total, the expression of 16 miRNA species was deregulated (>2-fold) in DN patients compared to healthy donors and T2D patients: the expression of 14 miRNAs (miR-320c, miR-6068, miR-1234-5p, miR-6133, miR-4270, miR-4739, miR-371b-5p, miR-638, miR-572, miR-1227-5p, miR-6126, miR-1915-5p, miR-4778-5p and miR-2861) was up-regulated whereas the expression of 2 miRNAs (miR-30d-5p and miR-30e-5p) was down-regulated. | 26930277 |
| Microalbuminuria | Epigenetic Alterations | The correlation of miRNA expression and micro-albuminuria levels could be replicated in a confirmation cohort. | 26930277 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. | 26930277 |
| Kidney Diseases | Epigenetic Alterations | Most of the deregulated miRNAs are involved in progression of renal diseases. | 26930277 |
| Stomach Carcinoma | Epigenetic Alterations | Long Noncoding RNA H19-Derived miR-675 Enhances Proliferation and Invasion via RUNX1 in Gastric Cancer Cells. | 26931432 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Identification of a six microRNA signature as a novel potential prognostic biomarker in patients with head and neck squamous cell carcinoma. | 26933913 |
| Primary malignant neoplasm | Epigenetic Alterations | We identified 19 miRNAs associated with over survival (OS) of patients with HNSCC in different clinical classes between 492 HNSCC tissues and 44 normal tissues from The Cancer Genome Atlas (TCGA) dataset. | 26933913 |
| Colorectal Cancer Pathway | Epigenetic Alterations | High blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2. | 26934556 |
| Clinical Coordinator | Epigenetic Alterations | The deregulation of microRNAs has been shown to be associated with the progression of CRC; however, the effects of high blood sugar levels on miR deregulation and, in turn, CRC remain unexplored. | 26934556 |
| Neoplasms | Epigenetic Alterations | Abnormal expression of long non-coding RNAs (lncRNAs) have been shown to play an important role in tumor biology. | 26935047 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA-204 suppresses human non-small cell lung cancer by targeting ATF2. | 26935060 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) play a critical role in cancer development and progression. | 26935060 |
| Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been reported to be dysregulated in cancer and to be important in the regulation of carcinogenesis, thus suggesting that this class of molecules may be used as biomarkers in cancer. | 26935146 |
| Cervix carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-200b suppresses cell invasion and metastasis by inhibiting the epithelial-mesenchymal transition in cervical carcinoma. | 26935156 |
| Neoplasms | Epigenetic Alterations | The expression of microRNA (miR)-200b is suppressed in numerous tumor types, leading to epithelial-mesenchymal transition, which enables solid tissue epithelial cancers to invade and metastasize. | 26935156 |
| Metastasis, Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | Long non-coding RNA-Low Expression in Tumor inhibits the invasion and metastasis of esophageal squamous cell carcinoma by regulating p53 expression. | 26935396 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Differential Expression of MicroRNAs in Chronic Obstructive Pulmonary Disease. | 26935494 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | The miRNAs expressions in normal and COPD patients were found differentially. | 26935494 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Aberrant microRNA expression is common in colorectal cancer and DNA methylation is believed to be responsible for this alteration. | 26935905 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenetic silencing of miR-181b contributes to tumorigenicity in colorectal cancer by targeting RASSF1A. | 26935905 |
| Colorectal Cancer Pathway | Epigenetic Alterations | This study indicated the clinical significance of miR-181b and the influence of miR-181b promoter region in epigenetic silencing of tumorigenicity in colorectal cancer, and implied the possible usage of miR-181b as a diagnostic and prognostic biomarker in colorectal cancer. | 26935905 |
| Behavior, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9. | 26936647 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miR)-133a expression has been reported to be downregulated in numerous human malignancies. | 26936647 |
| Malignant ascites | Epigenetic Alterations | Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant, and malignant ascites. | 26937257 |
| Primary malignant neoplasm, Ascites | Epigenetic Alterations | Among cancer patients, patients with DNA methylation-positive ascites showed an adverse clinical course (HR = 1.63, p = 0.039). | 26937257 |
| Ascites | Epigenetic Alterations | DNA methylation testing adds diagnostic and prognostic information and might constitute an effective ancillary method for the differential diagnosis of malignant, paramalignant, and benign ascites. | 26937257 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA Expression Profiling to Identify and Validate Reference Genes for the Relative Quantification of microRNA in Rectal Cancer. | 26937645 |
| Primary malignant neoplasm | Epigenetic Alterations | We performed high-throughput miRNA profiling (OpenArray(r)) on ten pairs of laser micro-dissected rectal cancer tissue and adjacent stroma. | 26937645 |
| Primary malignant neoplasm | Epigenetic Alterations | In the first validation experiment, a panel of miRNAs were analysed on 25 pairs of micro dissected rectal cancer tissue and adjacent stroma. | 26937645 |
| Primary malignant neoplasm | Epigenetic Alterations | Subsequently, the same miRNAs were analysed in 28 pairs of rectal cancer tissue and normal rectal mucosa. | 26937645 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | The long noncoding RNAs (lncRNAs) have long been clarified to participate in hepatocellular carcinoma (HCC) as a biomarker. | 26938303 |
| Kidney Failure, Acute | Epigenetic Alterations | Plasma microRNA-21 for the early prediction of acute kidney injury in patients undergoing major cardiac surgery. | 26940124 |
| Kidney Failure, Acute | Epigenetic Alterations | MicroRNA-21 (miR-21) has been described as an early biomarker for AKI. | 26940124 |
| Glioblastoma Multiforme | Epigenetic Alterations | Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma. | 26940435 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis. | 26943042 |
| Malignant Neoplasms | Epigenetic Alterations | Ultraconserved regions (UCRs) have been shown to originate non-coding RNA transcripts (T-UCRs) that have different expression profiles and play functional roles in the pathophysiology of multiple cancers. | 26943042 |
| Alzheimers Disease | Epigenetic Alterations | Common DNA methylation alterations of Alzheimers disease and aging in peripheral whole blood. | 26943045 |
| Neoplasms | Epigenetic Alterations | In conclusion, the increased levels of exosomal miR-200b and miR-200c mainly observed in advanced EOC suggest that these microRNAs may be involved in tumor progression. | 26943577 |
| Hematologic Neoplasms, Childhood Leukemia, Lymphoma | Epigenetic Alterations | Strikingly, the up-regulated miRNAs are mostly associated with hematologic cancers, such as lymphoma, leukemia. | 26943588 |
| Malignant Neoplasms, Liver carcinoma, Carcinoma of lung | Epigenetic Alterations | As a comparison, the up-regulated plasma miRNAs in middle-aged smokers are mostly associated with solid cancers, such as hepatocellular carcinoma and lung cancer, suggesting that smoking could have different influences on young adults and middle-aged adults. | 26943588 |
| Malignant Neoplasms | Epigenetic Alterations | In a conclusion, we identified the circulating miRNAs deregulated by cigarette smoking and revealed that the age-dependent deregulated miRNAs tend to be mainly involved in different types of human cancers. | 26943588 |
| Admitting diagnosis, Frontotemporal dementia | Epigenetic Alterations | We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. | 26944164 |
| Hypertensive (finding) | Epigenetic Alterations | Polymorphisms in the long non-coding RNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients. | 26944720 |
| Esophageal carcinoma | Epigenetic Alterations | Subsequently, aberrant DNA methylation of the miR-34a promoter was found in human esophageal cancer, and 5-AZA-dC inhibited DNA methylation of the miR-34a promoter. | 26944831 |
| Subarachnoid Hemorrhage | Epigenetic Alterations | Human cerebrospinal fluid microRNA: temporal changes following subarachnoid hemorrhage. | 26945012 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | miRNAs are involved in liver regeneration, and their expression is dysregulated in hepatocellular carcinoma (HCC). | 26945106 |
| Infection caused by Helicobacter pylori | Epigenetic Alterations | Interaction between inflammatory mediators and miRNAs in Helicobacter pylori infection. | 26945693 |
| Infection caused by Helicobacter pylori | Epigenetic Alterations | Our results showed that H. pylori infection leads to up-regulation of TNFA, IL6, IL12A and IL2 and down-regulation of miRNAs. | 26945693 |
| Delayed Release Dosage Form | Epigenetic Alterations | Specific miRNAs involved in DR development and/or progression can be used as molecular biomarkers, and based on these, for developing future biotherapies. | 26948458 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Gastric cancer (GC) is the fourth most prevalent type of cancer worldwide, which is usually caused by the interaction between environmental and genetic factors, or epigenetic aspects. | 26949090 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Referring to the non-coding RNAs, miR-128b has been reported to be associated with many tumour cases, and exerts distinct functions in different types of cancers. | 26949090 |
| Malignant Neoplasms | Epigenetic Alterations | As one of the most widely studied epigenetic modifications, DNA methylation has an important influence on human traits and cancers. | 26949191 |
| Malignant Childhood Neoplasm | Epigenetic Alterations | Dynamic variations in DNA methylation have been reported in malignant neoplasm and aging; however, the mechanisms remain poorly understood. | 26949191 |
| Primary malignant neoplasm | Epigenetic Alterations | By constructing an age-associated and cancer-related weighted network (ACWN) based on the correlation of the methylation level and the protein-protein interaction, we found that DNA methylation changes associated with age were closely related to the occurrence of cancer. | 26949191 |
| Primary malignant neoplasm | Epigenetic Alterations | Our results will facilitate further studies regarding the impact of the epigenetic effects of aging on diseases and will aid in the development of tailored cancer preventive strategies. | 26949191 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Circulating Long Noncoding RNA UCA1 as a Novel Biomarker of Acute Myocardial Infarction. | 26949706 |
| Cardiovascular Diseases | Epigenetic Alterations | Recent studies have showed that long noncoding RNAs (lnc RNA) play important roles in pathophysiology of cardiovascular diseases, but the investigations are still in their infancy. | 26949706 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Tumor epigenetic defects are of increasing relevance to clinical practice, because they are druggable targets for cancer therapy using chromatin-remodeling agents (CRAs). | 26949823 |
| Gastric Adenocarcinoma | Epigenetic Alterations | Gastric adenocarcinoma microRNA profiles in fixed tissue and in plasma reveal cancer-associated and Epstein-Barr virus-related expression patterns. | 26950485 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA expression in formalin-fixed paraffin-embedded tissue (FFPE) or plasma may add value for cancer management. | 26950485 |
| Stomach Carcinoma | Epigenetic Alterations | Expression of viral microRNAs in concert with unique human microRNAs provides novel insights into viral oncogenesis and reinforces the potential for microRNA profiles to aid in classifying gastric cancer subtypes. | 26950485 |
| Virus Diseases | Epigenetic Alterations | EBV-infected versus uninfected cancers expressed multiple EBV-encoded microRNAs, and concomitant dysregulation of four human microRNAs suggests that viral infection may alter cellular biochemical pathways. | 26950485 |
| Non-Cancer Related Death, Primary malignant neoplasm | Epigenetic Alterations | Human microRNAs were dysregulated between malignant and benign gastric mucosa and between plasma of cancer patients and non-cancer controls. | 26950485 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | PIK3C2A is a gene-specific target of microRNA-518a-5p in imatinib mesylate-resistant gastrointestinal stromal tumor. | 26950487 |
| Myeloid neoplasm | Epigenetic Alterations | Genetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and prognosis. | 26950655 |
| SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) share common features: elevated oxidative stress, DNA repair deficiency, and aberrant DNA methylation. | 26950655 |
| ovarian neoplasm | Epigenetic Alterations | miRNA deregulation evinces a remarkable role in ovarian cancer tumorigenesis. | 26951510 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNA-199a (miR-199a) is known to be involved in cancer development and progression. | 26951510 |
| Atrial Fibrillation | Epigenetic Alterations | Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery. | 26952538 |
| Huntington Disease | Epigenetic Alterations | DNA methylation profiling in human Huntingtons disease brain. | 26953320 |
| Hodgkin Disease, Huntington Disease | Epigenetic Alterations | Despite extensive progress in Huntingtons disease (HD) research, very little is known about the association of epigenetic variation and HD pathogenesis in human brain tissues. | 26953320 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | It is suggested that miRNA may be a potential tumor marker for breast cancer. | 26957267 |
| MIR21 gene, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival. | 26957558 |
| MIR21 gene, Neoplasms | Epigenetic Alterations | PTGS2-driven inflammatory responses can induce tumor expression of microRNA MIR21 (miR-21) that can increase local PGE2 level by downregulating PGE2-metabolizing enzymes. | 26957558 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Tumor Evolution Inferred by Patterns of microRNA Expression through the Course of Disease, Therapy, and Recurrence in Breast Cancer. | 26957561 |
| Breast Carcinoma | Epigenetic Alterations | Exploration of evolving disease by profiling 800 miRNA expression from serial samples of individual breast cancer patients at several time points: pretreatment, posttreatment, lymph nodes, and recurrence sites when available (58 unique samples from 19 patients). | 26957561 |
| Neoplasms | Epigenetic Alterations | These miRNAs were related to tumor proliferation and to the cell-cycle pathway, and their mRNA targets showed anticorrelated expression. | 26957561 |
| Metastasis | Epigenetic Alterations | Interestingly, the level of these miRNAs was lowest in matched recurrent samples from distant metastasis, indicating a gradual increase in proliferative potential through the course of disease. | 26957561 |
| Thyroid Neoplasm | Epigenetic Alterations | miRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors. | 26960768 |
| Carcinoma, Papillary, Papillary thyroid carcinoma | Epigenetic Alterations | Relative expression of six microRNAs (miR-146b, -21, -221, -222, 375, -199b) appeared significantly different in BRAF(V600E)-positive samples (all classified as papillary thyroid carcinomas) compared to BRAF(V600E)-negative papillary carcinoma samples. | 26960768 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNAs (miRs), short (20-25 nucleotides) non-coding RNAs, have been described as prognosticators and predictors for breast cancer in recent years. | 26962366 |
| Breast Carcinoma, Fibrosis Assessment | Epigenetic Alterations | DNA methylation profiling of dermal fibroblasts obtained from breast cancer patients prior to irradiation identifies differences associated with fibrosis. | 26964756 |
| DGKA gene, Fibrosis Assessment | Epigenetic Alterations | Decreased DNA methylation at this enhancer enables recruitment of the profibrotic transcription factor early growth response 1 (EGR1) and facilitates radiation-induced DGKA transcription in cells from patients later developing fibrosis. | 26964756 |
| Fibrosis Assessment | Epigenetic Alterations | Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. | 26964756 |
| Fibrosis Assessment | Epigenetic Alterations | Since the molecular causes for fibrosis are largely unknown, we analyse if epigenetic regulation might explain inter-individual differences in fibrosis risk. | 26964756 |
| Neoplasms | Epigenetic Alterations | Intervention of CUL4A(DCAF1) ubiquitin ligase complex led to fluctuation in expression levels of DICER1 and microRNAs, and thus affected tumor growth in a mouse xenograft model. | 26965998 |
| Squamous cell carcinoma, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Although the importance of the epigenetic changes in tumors, including oral squamous cell carcinomas (OSCCs), is now becoming apparent, the mechanisms that trigger or cause aberrant DNA methylation in cancer are still unrevealed. | 26966018 |
| SERPINB3 wt Allele | Epigenetic Alterations | DNMT gene expression could be a potential prognostic marker that might lead to an improvement in diagnosis, prognosis, and prospective use of epigenetic-targeted therapy of OSCC. | 26966018 |
| Sjogrens Syndrome", Fatigue | Epigenetic Alterations | Epigenome-wide DNA methylation patterns associated with fatigue in primary Sjogrens syndrome. | 26966136 |
| Fatigue | Epigenetic Alterations | Recent studies indicate that epigenetic mechanisms may be involved in the expression of fatigue, a prominent feature of primary SS (pSS). | 26966136 |
| Neoplasm Metastasis | Epigenetic Alterations | Recent evidence suggests that microRNAs (miRNAs) are involved in cancer metastasis and are promising therapeutic targets. | 26968949 |
| SF3B1 wt Allele | Epigenetic Alterations | Furthermore, our previous work has identified a spectrum of innate immune genes in MDS CD34+ cells that are deregulated via abnormal promoter histone methylation. | 26970171 |
| Admitting diagnosis | Epigenetic Alterations | Elevated miRNA-9 and miRNA-128a found in AD brain tissues might modulate the expression of ASS and NOS, respectively. | 26971935 |
| Degenerative polyarthritis | Epigenetic Alterations | Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1. | 26972586 |
| Carcinoma of lung, Chronic disease | Epigenetic Alterations | MicroRNAs play important roles in the development of human chronic diseases including lung cancer. | 26973201 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | We hypothesize that circulating miRNA expression profiles vary according to differences in body mass index (BMI) and T2D and circulating miRNAs may reflect adipose tissue expression. | 26973292 |
| Malignant Neoplasms | Epigenetic Alterations | The epigenetic mark 5-hydroxymethylcytosine (5hmC) is reduced in various cancers, and this may involve reduced expression of the ten-eleven translocation 1 (TET1) enzyme. | 26973719 |
| Pancreatic carcinoma | Epigenetic Alterations | The overexpression of microRNA-21 (miR-21) in pancreatic cancer has been implicated in drug resistance to gemcitabine. | 26977002 |
| Peripheral Arterial Diseases | Epigenetic Alterations | Some emerging risk factors such as oxidative stress biomarkers and microRNAs (miRs) may add additional value to the established risk factors for peripheral artery disease (PAD). | 26980776 |
| Neoplasms | Epigenetic Alterations | Genome-wide DNA methylation profiling of the tumor and matched non-cancerous mucosa was performed. | 26984265 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | The different DNA methylation clusters of the tumors and normal tissue indicate that aberrant DNA methylation is a distinct feature of gastric cancer, although there is little difference in the overall, and low, methylation levels between the two tissue types. | 26984265 |
| Stomach Carcinoma | Epigenetic Alterations | A large number of epigenetic alterations has been found to be implicated in the etiology of gastric cancer. | 26984265 |
| Neoplasms | Epigenetic Alterations | We also observed a difference in the miRNA expression with respect to the histological type of the tumors. | 26984519 |
| Breast Carcinoma | Epigenetic Alterations | In conclusion, our findings suggest that miRNA analysis of breast ductal fluid is feasible and potentially very useful for the detection of breast cancer. | 26984519 |
| Breast Carcinoma | Epigenetic Alterations | Recent studies suggest that microRNAs show promise as excellent biomarkers for breast cancer; however there is still a high degree of variability between studies making the findings difficult to interpret. | 26984519 |
| Ductal Breast Carcinoma, Neoplasms | Epigenetic Alterations | We identified 17 differentially expressed miRNAs between tumor and paired normal samples from patients with ductal breast carcinoma. | 26984519 |
| Breast Carcinoma, Metastasis, Mammary Neoplasms | Epigenetic Alterations | Most of these miRNAs have various roles in breast cancer tumorigenesis, invasion and metastasis, therapeutic response, or are associated with several clinical and pathological characteristics of breast tumors. | 26984519 |
| Breast Carcinoma, Milk, Human | Epigenetic Alterations | Moreover, some miRNAs were also detected in other biological fluids of breast cancer patients such as serum (miR-23b, -133b, -181a, 338-3p, -625), plasma (miR-200a), and breast milk (miR-181a). | 26984519 |
| Hypertensive (finding) | Epigenetic Alterations | Comparative microRNA profiling in relation to urinary albumin excretion in newly diagnosed hypertensive patients. | 26984682 |
| organic heart disease, Hypertensive disease | Epigenetic Alterations | We assessed the expression of the miRNAs miRNA-1, miRNA-133a, miRNA-26b, miRNA-208b, miRNA-499 and miRNA-21 in consecutive subjects with untreated newly diagnosed essential hypertension (aged 62.5+-9.7 years) and with no indications of other organic heart disease. | 26984682 |
| Hypertensive disease | Epigenetic Alterations | In conclusion, miRNA-208b and miRNA-133a show distinct profiling in peripheral blood cells isolated from untreated patients with recently diagnosed essential hypertension. | 26984682 |
| Chromosomal Instability, Brain Ependymoma, Ependymoma | Epigenetic Alterations | DNA methylation profiling can distinguish 4 subgroups of intracranial ependymomas, including supratentorial (ST) ependymomas with Yes-associated protein 1 fusion (YAP1), ST ependymomas with fusion of v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), posterior fossa ependymomas with balanced genome, and posterior fossa ependymomas with chromosomal instability. | 26984744 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a. | 26986232 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Aberrant microRNA (miRNA or miR) expression has been reported to contribute to the pathogenesis of hepatocellular carcinoma (HCC). | 26986232 |
| Hollings Cancer Center | Epigenetic Alterations | However, the involvement of specific miRNAs in HCC remains to be elucidated. | 26986232 |
| Malignant Neoplasms, Squamous cell carcinoma, SERPINB3 wt Allele | Epigenetic Alterations | Although microRNA-155 (miR-155) is known to play an important role in many cancers, its expression and function in oral squamous cell carcinoma (OSCC) was not fully understood. | 26986233 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Epigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients. | 26989022 |
| Neoplasms | Epigenetic Alterations | In conclusion, TMPRSS4 is a novel independent prognostic biomarker regulated by epigenetic changes in SCC and a potential therapeutic target in this tumor type, where targeted therapy is still underdeveloped. | 26989022 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | The overall biological role and clinical significance of long non-coding RNA H19 in colorectal cancer (CRC) remain largely unknown. | 26989025 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3. | 26989025 |
| Prostate Cancer Pathway | Epigenetic Alterations | Dysregulation of miRNA has been implicated in the development and progression of prostate cancer. | 26990571 |
| Prostate Cancer Pathway, Metastasis | Epigenetic Alterations | Through next generation miRNA sequencing, we recently identified a panel of five miRNAs associated with prostate cancer recurrence and metastasis. | 26990571 |
| Prostate Cancer Pathway | Epigenetic Alterations | Of the five miRNAs, miR-301a had the strongest association with prostate cancer recurrence. | 26990571 |
| Clinical Coordinator, Adenoma | Epigenetic Alterations | MicroRNAs profile in CSC-enriched colonic mucosal cells, expressed as ratio of high-risk (>=3 adenomas) to low-risk (no adenoma) CRC patients revealed an 8-fold increase in miR-1207-5p in AAs, compared to a 1.2-fold increase of the same in White people. | 26990997 |
| Esophagitis, Pneumonitis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We genotyped 233 SNPs (161 in microRNA binding site and 72 in processing gene) and analyzed their associations with pneumonitis and esophagitis in 167 stage III NSCLC patients received definitive radiation therapy. | 26991123 |
| Pneumonitis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our results provide strong evidence that microRNA-related genetic variations contribute to the development of radiotherapy-induced acute esophagitis and pneumonitis and could thus serve as biomarkers to help accurately predict radiotherapy-induced toxicity in NSCLC patients. | 26991123 |
| Primary malignant neoplasm | Epigenetic Alterations | In many cancer types, the expression and function of ~22 nucleotide-long microRNAs (miRNA) is deregulated. | 26992225 |
| Bone lesion | Epigenetic Alterations | MicroRNAs have been reported to be involved in development of bone lesions in MM. | 26995755 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation in cancer has become the issue of passionate investigation. | 26997221 |
| Traumatic injury | Epigenetic Alterations | Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. | 26997371 |
| Malignant Neoplasms, Lymphoma | Epigenetic Alterations | MicroRNA, which regulates gene expression, has critical functions in the growth and progression of many cancers and contributes to the pathogenesis of lymphoma. | 26997445 |
| Malignant Neoplasms, Medial collateral ligament | Epigenetic Alterations | Several studies have revealed that microRNAs (miRs) from the miR-17-92 cluster are among the most deregulated miRNAs in human cancers, still little is known about this cluster in MCL. | 26998831 |
| Malignant Neoplasms, Carcinogenesis | Epigenetic Alterations | MicroRNA (miR)-503 is downregulated in several cancers and plays a tumor-suppressive role in carcinogenesis. | 26999740 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer. | 26999740 |
| Malignant neoplasm of larynx | Epigenetic Alterations | Small non-coding RNAs appear to be very promising biomarkers - and so remain the focus of extensive investigation in laryngeal cancer. | 27002759 |
| Laryngeal Squamous Cell Carcinoma | Epigenetic Alterations | New miRNA expression abnormalities in laryngeal squamous cell carcinoma. | 27002759 |
| DAB2IP gene, Carcinoma, Transitional Cell | Epigenetic Alterations | Epigenetic regulation of DAB2IP protein appears to play an important role in human urothelial carcinoma. | 27003158 |
| Diabetes Mellitus | Epigenetic Alterations | Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus. | 27005938 |
| Ulcerative Colitis, Inflammatory Bowel Diseases, Clinical Coordinator, Crohn Disease, Colorectal Cancer Pathway, CDISC Integrated Basic Data Structure Dataset | Epigenetic Alterations | Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohns disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). | 27006956 |
| Malignant Neoplasms, Stomach Carcinoma, Neoplasms | Epigenetic Alterations | The oncogenic and tumor suppressor roles of miRNAs have been identified in cancers especially in gastric cancer, which is one of the most prevalent cancers. | 27007598 |
| Stomach Carcinoma | Epigenetic Alterations | Circulating MicroRNA-26a in Plasma and Its Potential Diagnostic Value in Gastric Cancer. | 27010210 |
| Neoplasms | Epigenetic Alterations | For classification, tumors were characterized by SDHA, B, C, or D (SDHX) mutations and other genetic and epigenetic alterations, including presence of mutations in germline. | 27011036 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-186 (miR-186) plays an important role in the pathogenesis of several cancers. | 27012040 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-134 modulates glioma cell U251 proliferation and invasion by targeting KRAS and suppressing the ERK pathway. | 27012554 |
| Carcinogenesis, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Dysregulated microRNA-134 (miR-134) has been observed in glioma carcinogenesis, and studies suggested that the ERK pathway plays vital roles in glioma cell growth and proliferation. | 27012554 |
| Acute GVH disease, Lymphoma | Epigenetic Alterations | Circulating miRNA panel for prediction of acute graft-versus-host disease in lymphoma patients undergoing matched unrelated hematopoietic stem cell transplantation. | 27013207 |
| Graft-vs-Host Disease | Epigenetic Alterations | Remarkably, these upregulated microRNAs could be detected before the onset of aGVHD. | 27013207 |
| Graft-vs-Host Disease | Epigenetic Alterations | Pathway prediction analysis indicated that these microRNAs may regulate critical pathways involved in aGVHD pathogenesis. | 27013207 |
| Graft-vs-Host Disease | Epigenetic Alterations | Considering the noninvasive characteristics of plasma sampling and the feasibility of detecting miRNAs after allo-HSCT using real-time polymerase chain reaction, our results indicate that circulating microRNAs have the potential to enable an earlier aGVHD diagnosis and might assist in individualizing therapeutic strategies after MUD allo-HSCT. | 27013207 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Although microRNAs have been elaborated to participate in various physiological and pathological processes, their functions in TRAIL resistance of acute myeloid leukemia (AML) remain obscure. | 27013583 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-371-5p targets SOX2 in gastric cancer. | 27015119 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Long noncoding RNA MALAT1 promotes malignant development of esophageal squamous cell carcinoma by targeting b-catenin via Ezh2. | 27015363 |
| Dermatitis | Epigenetic Alterations | We conclude that this miRNA may serve as a mechanistic link between psoriatic skin inflammation and its systemic comorbidities. | 27015452 |
| Psoriasis | Epigenetic Alterations | MicroRNAs (miRNAs) are recently discovered gene regulators that play important roles in psoriasis skin inflammation. | 27015452 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells. | 27015551 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Recent reports show that long non-coding RNAs (lncRNAs) are emerging as significant functional regulators in the development of tumors, including bladder cancer. | 27015551 |
| AMD1 wt Allele, Vitreous humor | Epigenetic Alterations | MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD. | 27015561 |
| AMD1 wt Allele | Epigenetic Alterations | To our knowledge, our study is the first to correlate vitreal and plasma miRNA signatures with NV AMD, highlighting potential future worth as biomarkers and providing insight on NV AMD pathogenesis. | 27015561 |
| Irritable Bowel Syndrome | Epigenetic Alterations | MicroRNA-199b expression level and coliform count in irritable bowel syndrome. | 27015896 |
| Coliform bacteria, Irritable Bowel Syndrome | Epigenetic Alterations | Moreover, there was a negative correlation between the count of Coliform and the serum miRNA-199b expression level in IBS. | 27015896 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are small noncoding RNAs involved in cancer development. | 27016415 |
| Paget Disease | Epigenetic Alterations | Extramammary Pagets disease (EMPD) is a rare cutaneous malignancy and the role of miRNAs in EMPD remains unknown. | 27016415 |
| Prostate Cancer Pathway, Carcinogenesis, Prostatic Intraepithelial Neoplasias | Epigenetic Alterations | MicroRNA alteration and putative target genes in high-grade prostatic intraepithelial neoplasia and prostate cancer: STAT3 and ZEB1 are upregulated during prostate carcinogenesis. | 27017949 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Among them, 10 paired HGPIN and PCa were prepared to perform miRNA microarray and quantitative real-time PCR. | 27017949 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Epigenetic regulation has been postulated to affect glucose metabolism, insulin sensitivity and the risk of type 2 diabetes. | 27019061 |
| leukemia, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Role of microRNA-29b in myelodysplastic syndromes during transformation to overt leukaemia. | 27020498 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Chromosome 7q32 is a frequently deleted region in myelodysplastic syndromes (MDSs) and encodes the microRNAs (miRNAs) miR-29a/miR-29b. | 27020498 |
| Nasopharyngeal carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) play a critical role in cancer progression, including in nasopharyngeal carcinoma (NPC). | 27020592 |
| Parkinson Disease | Epigenetic Alterations | Altered Long Noncoding RNA Expression Precedes the Course of Parkinsons Disease-a Preliminary Report. | 27021022 |
| Degenerative polyarthritis | Epigenetic Alterations | Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage. | 27023358 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNAs (miRNAs) are emerging as important regulators in osteoarthritis pathogenesis. | 27023516 |
| Platelet aggregation | Epigenetic Alterations | Lower cg03548645 (TRAF3) DNA methylation levels were correlated with an increased platelet aggregation (r=-0.29, P=0.0075). | 27026631 |
| Cerebrovascular accident | Epigenetic Alterations | This study suggests for the first time that epigenetics may significantly contribute to the variability of clopidogrel response and recurrence of ischemic events in patients with stroke. | 27026631 |
| Cerebrovascular accident | Epigenetic Alterations | TRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke. | 27026631 |
| NCALD gene, Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Upregulation of long intergenic noncoding RNA 00673 promotes tumor proliferation via LSD1 interaction and repression of NCALD in non-small-cell lung cancer. | 27027352 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | In more recent years, mutiple lines of evidence have highlighted long noncoding RNAs (lncRNAs) serve as novel class of regulators of cancer biological processes, including proliferation, apoptosis and metastasis. | 27027352 |
| Diabetes Mellitus | Epigenetic Alterations | Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes. | 27029739 |
| Breast Carcinoma | Epigenetic Alterations | Genetic and epigenetic factors affect RET gene expression in breast cancer cell lines and influence survival in patients. | 27034161 |
| Breast Carcinoma | Epigenetic Alterations | Tumor-promoting function of single nucleotide polymorphism rs1836724 (C3388T) alters multiple potential legitimate microRNA binding sites at the 3-untranslated region of ErbB4 in breast cancer. | 27035115 |
| Breast Carcinoma | Epigenetic Alterations | Bioinformatics analysis identified rs1836724 to be a polymorphism in the seed region of four miRNA binding sites (hsa-miR335-5p, hsa-miR-28-5p, has-miR-708-5p and has-miR-665), which may participate in the development of breast cancer. | 27035115 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1. | 27035227 |
| Primary malignant neoplasm | Epigenetic Alterations | The expression of microRNA-335 (miR-335) has been demonstrated to be downregulated in numerous types of cancer. | 27035227 |
| Esophageal carcinoma | Epigenetic Alterations | Exosome-shuttling microRNA-21 promotes cell migration and invasion-targeting PDCD4 in esophageal cancer. | 27035745 |
| Neoplasms | Epigenetic Alterations | Recent evidence indicates that exosomes can mediate certain microRNAs (miRNAs) involved in a series of biological functions in tumor occurrence and development. | 27035745 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-197 inhibits cell proliferation by targeting GAB2 in glioblastoma. | 27035789 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Identification of a three-miRNA signature as a blood-borne diagnostic marker for early diagnosis of lung adenocarcinoma. | 27036025 |
| Adenocarcinoma of lung, stage I | Epigenetic Alterations | Taken together, these findings suggest that the 3 miRNA-based biomarker might serve as a novel non-invasive approach for diagnosis of early-stage lung adenocarcinoma. | 27036025 |
| Adenocarcinoma of lung, stage I | Epigenetic Alterations | Based on the results from the screening and validation process, 3 miRNAs (miR-532, miR-628-3p and miR-425-3p) were found to display significantly different expression levels in early-stage lung adenocarcinoma, as compared to those in healthy controls. | 27036025 |
| Carcinoma of lung, Adenocarcinoma of lung (disorder), Lung diseases | Epigenetic Alterations | Importantly, these three miRNAs could also distinguish lung adenocarcinoma from lung benigh diseases and other subtypes of lung cancer. | 27036025 |
| Malignant Neoplasms, Magnetic-Targeted Carriers | Epigenetic Alterations | We focused our attention on the strongest up-regulated miRNA in MTC samples, miR-375, the deregulation of which has been previously observed in a variety of human malignancies including MTC. | 27036030 |
| Primary malignant neoplasm | Epigenetic Alterations | As a mechanism underlying the reduced expression of NEIL1 in cancer, the epigenetic silencing of NEIL1 through promoter hypermethylation was found. | 27042257 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Non-small cell lung cancer (NSCLC) is related to the genetic and epigenetic factors. | 27042875 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-96 (miR-96) is an oncomiR that facilitates the development of malignant tumors by promoting growth, proliferation, and survival of cancer cells. | 27044381 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | MicroRNA-130b functions as a tumor suppressor by regulating RUNX3 in epithelial ovarian cancer. | 27048832 |
| ovarian neoplasm | Epigenetic Alterations | To evaluate the clinical significance of microRNA (miR)-130b-Runt domain transcription factor (RUNX3) axis and its effects on oncogenic phenotypes of human epithelial ovarian cancer (EOC). | 27048832 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression. | 27049921 |
| Cessation of life | Epigenetic Alterations | Furthermore, these genotypes were significantly associated with reduced risk of overall death, death owing to disease, and recurrence after adjustment for important prognostic confounders, indicating that these pre-miRNA polymorphisms may be prognostic biomarkers for SCCNOP. | 27050146 |
| Primary malignant neoplasm | Epigenetic Alterations | Functional polymorphisms of miRNAs may affect the function and target expression of miRNAs, which can, in turn, affect the biological activity, etiology, and prognosis of cancer. | 27050146 |
| Autoimmune thrombocytopenia | Epigenetic Alterations | Aberrant expression of long noncoding RNA TMEVPG1 in patients with primary immune thrombocytopenia. | 27050808 |
| Autoimmune thrombocytopenia, Inosine Triphosphate | Epigenetic Alterations | It has been reported that plasma IFNG concentration was elevated and partly due to dysregulation of micro RNAs in patients with primary immune thrombocytopenia (ITP). | 27050808 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Here, we provide theoretical basis for glioma development and prognosis involving DNA-methylation driven silencing of SEMA3B, and thus, SEMA3B is a potential target for directed treatments against glioma. | 27050958 |
| Primary malignant neoplasm | Epigenetic Alterations | Alteration of Human Papillomavirus Type 16 Genetic and Epigenetic Profiles in Cervical Cancer Patients Is Indicative of Poor Disease Prognosis: A Cohort Analysis. | 27051049 |
| Admitting diagnosis | Epigenetic Alterations | DNA methylation, and particularly 5hmC, may be involved in regulating TREM2 mRNA expression in the AD brain. | 27051467 |
| Stomach Carcinoma | Epigenetic Alterations | Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer. | 27056384 |
| Carcinoma, Transitional Cell, Malignant - descriptor | Epigenetic Alterations | Urothelial carcinoma associated 1 (UCA1) gene is a long noncoding RNA (lncRNA), which shows expression and function abnormality in some kinds of malignant cancers. | 27056384 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-452 promotes stem-like cells of hepatocellular carcinoma by inhibiting Sox7 involving Wnt/b-catenin signaling pathway. | 27058905 |
| Glioma | Epigenetic Alterations | The decrease of microRNA-452 (miR-452) in gliomas promoted stem-like features and tumorigenesis. | 27058905 |
| Admitting diagnosis | Epigenetic Alterations | We examined the epigenetic regulatory mechanism of HMOX1 and its application as a diagnostic and prognostic biomarker for AD. | 27058954 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | High expression of p15 antisense RNA was frequently found among AML patients, and may play an important role in epigenetic silencing of p15. | 27060304 |
| Alzheimers Disease", Neurotoxicity Syndromes | Epigenetic Alterations | 5-Hydroxymethylation-associated epigenetic modifiers of Alzheimers disease modulate Tau-induced neurotoxicity. | 27060332 |
| Admitting diagnosis | Epigenetic Alterations | Pathogenesis of AD is incompletely understood; evidence suggests a role for epigenetic regulation, in particular the cytosine modifications 5-methylcytosine and 5-hydroxymethylcytosine (5hmC). | 27060332 |
| Admitting diagnosis | Epigenetic Alterations | We identified AD-associated single nucleotide polymorphisms (SNPs) located within or near DhMLs, suggesting these SNPs may identify regions of epigenetic gene regulation that play a role in AD pathogenesis. | 27060332 |
| Primary malignant neoplasm | Epigenetic Alterations | Polymorphisms in DNMT3B and MTHFR have been implicated in cancer etiology; however, it is increasingly clear that gene-specific DNA methylation also affects gene expression. | 27062459 |
| Adenoma of large intestine | Epigenetic Alterations | In addition, increasing DNA methylation in the gene-coding area of DNMT3B was associated with higher risk of colorectal adenomas (OR = 1.34; 95% CI: 1.01-1.79 per SD). | 27062459 |
| Adenoma of large intestine | Epigenetic Alterations | Genetic and epigenetic variation in the DNMT3B and MTHFR genes and colorectal adenoma risk. | 27062459 |
| Adenoma of large intestine, Colorectal Cancer Pathway, Clinical Coordinator | Epigenetic Alterations | This research provides novel evidence that genetic and epigenetic variations contribute to colorectal adenoma risk, precursor to the majority of colorectal cancer (CRC). | 27062459 |
| Diabetes Mellitus | Epigenetic Alterations | In a third subsample (all with diabetes; n = 7 normal BMI + low insulin level, n = 9 normal BMI + high insulin level, n = 9 obese + high insulin level), we assessed DNA methylation. | 27062899 |
| Diabetes Mellitus | Epigenetic Alterations | Observed differences in serum BDNF levels, genetic variants, and DNA methylation patterns across different glucose metabolic state suggest that BDNF may be involved in the pathophysiological process of insulin resistance and type 2 diabetes. | 27062899 |
| melanoma, Malignant neoplasm of skin | Epigenetic Alterations | We further defined two other miRNA modulators of EMT (miR-191 and let-7a) in serum exosomes for differentiating stage I melanoma patients from non-melanoma subjects. | 27063098 |
| Primary malignant neoplasm | Epigenetic Alterations | Mammalian microRNAs (miR) regulate the expression of genes relevant for the development of adaptive and innate immunity against cancer. | 27063186 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-1976 functions as a tumor suppressor and serves as a prognostic indicator in non-small cell lung cancer by directly targeting PLCE1. | 27063799 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Herein, we demonstrated that miR-1976 is a tumor-suppressor miRNA in NSCLC progression. | 27063799 |
| Humor | Epigenetic Alterations | MicroRNA Profiling in Aqueous Humor of Individual Human Eyes by Next-Generation Sequencing. | 27064390 |
| Humor | Epigenetic Alterations | The authors adopted next-generation sequencing (NGS) techniques to further characterize the miRNA profile in single samples of 60 to 80 mL human aqueous humor. | 27064390 |
| Humor | Epigenetic Alterations | The aqueous humor miRNA profile shows some overlap with published NGS-derived inventories of circulating miRNAs in blood plasma with high prevalence of human miR-451a, -21, and -16. | 27064390 |
| Glaucoma, CTCAE | Epigenetic Alterations | The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-b and Wnt, which are important in intraocular pressure regulation and glaucoma. | 27064390 |
| Humor | Epigenetic Alterations | Extracellular microRNAs (miRNAs) in aqueous humor were suggested to have a role in transcellular signaling and may serve as disease biomarkers. | 27064390 |
| Humor | Epigenetic Alterations | In contrast to blood, miR-184, -4448, -30a, -29a, -29c, -19a, -30d, -205, -24, -22, and -3074 were detected among the 20 most prevalent miRNAs in aqueous humor. | 27064390 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Deregulation of seven CpG island-harboring miRNAs in bladder cancer: miR-155 and miR-23b as the most promising oncomiRs. | 27064870 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA SNHG5 suppresses gastric cancer progression by trapping MTA2 in the cytosol. | 27065326 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a. | 27065331 |
| Squamous cell carcinoma | Epigenetic Alterations | Despite there being over 35,000 different long noncoding RNA (lncRNA) sequences described little is known regarding their molecular-pathological role in cutaneous squamous cell carcinoma (cSCC). | 27067026 |
| Squamous cell carcinoma of skin | Epigenetic Alterations | Expression profiles of long noncoding RNAs in cutaneous squamous cell carcinoma. | 27067026 |
| Mammary Neoplasms, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | We determined the average departure of tumor DNA methylation from adjacent normal breast DNA methylation using Illumina 450K methylation data from 700 invasive breast tumors and 90 adjacent normal breast tissues in The Cancer Genome Atlas. | 27070496 |
| Neoplasms | Epigenetic Alterations | From this we generated a novel summary measure of altered DNA methylation, the DNA methylation dysregulation index (MDI), and examined the relation of MDI with tumor characteristics and summary measures that quantify cumulative burden of genetic mutation and copy number alterations. | 27070496 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma. | 27070496 |
| Neoplasms | Epigenetic Alterations | A recursively partitioned mixture model of all 3 somatic alteration burden measures resulted in classes of tumors whose epigenetic and genetic burden profile were associated with the PAM50 subtype and mutations in TP53, PIK3CA, and CDH1. | 27070496 |
| Breast Carcinoma | Epigenetic Alterations | Together, our work presents a novel framework for characterizing the epigenetic burden and adds to the understanding of the aggregate impact of epigenetic and genetic alterations in breast cancer. | 27070496 |
| Malignant tumor of colon | Epigenetic Alterations | Long Non-Coding RNA lincRNA-ROR Promotes the Progression of Colon Cancer and Holds Prognostic Value by Associating with miR-145. | 27071407 |
| Malignant neoplasm of liver | Epigenetic Alterations | Large intergenic non-coding RNA ribonucleic acids-ROR (lincRNA-ROR) has been reported to exert impacts on the maintenance of induced pluripotent stem cells and embryonic stem cells, and play important roles in human hepatocellular cancer. | 27071407 |
| STK19 gene | Epigenetic Alterations | RP1-13D10.2 is a long noncoding RNA that regulates LDLR and may contribute to low-density lipoprotein cholesterol response to statin treatment. | 27071970 |
| Heart failure | Epigenetic Alterations | Differential microRNA expression in peripheral blood has been observed in patients with heart failure, suggesting their value as potential biomarkers and likely contributors to disease mechanisms. | 27072074 |
| Cardiovascular Diseases | Epigenetic Alterations | The expression of microRNAs was analysed using real-time PCR by the miScript miRNA PCR Array Human Cardiovascular Disease. | 27072074 |
| Heart failure, Heart Diseases | Epigenetic Alterations | In silico analyses suggest that the transcardiac gradient of microRNAs in heart failure may target pathways related to heart disease. | 27072074 |
| Heart failure, Fibrosis Assessment | Epigenetic Alterations | The microRNAs described here may have a role in the pathophysiology of heart failure as they might be involved in pathways related to disease progression, including fibrosis. | 27072074 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Regulation of UHRF1 by dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p): Inhibition of bladder cancer cell aggressiveness. | 27072587 |
| Neoplasms | Epigenetic Alterations | The identification of the molecular target of a tumor suppressive miRNAs provides novel insights into the potential mechanisms of BC oncogenesis and suggests novel therapeutic strategies. | 27072587 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNA-124 Functions as a Tumor Suppressor by Regulating CDH2 and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer. | 27073840 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Abnormal expression of microRNA-124 (miR-124) was found in non-small cell lung cancer (NSCLC). | 27073840 |
| Prostate Cancer Pathway | Epigenetic Alterations | miRNA-154-5p Inhibits Proliferation, Migration and Invasion by Targeting E2F5 in Prostate Cancer Cell Lines. | 27074041 |
| Non-alcoholic Fatty Liver Disease | Epigenetic Alterations | Relationships between circulating microRNA-122 (miR-122) and histological features of nonalcoholic fatty liver disease (NAFLD) are unclear. | 27074850 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Plasma miRNAs in predicting radiosensitivity in non-small cell lung cancer. | 27075472 |
| palladium, Stable Disease | Epigenetic Alterations | Four miRNAs (hsa-miR-98-5p, hsa-miR-302e, hsa-miR-495-3p, and hsa-miR-613) demonstrated a higher expression in effective group (CR + PR, 15 cases) than in ineffective group (SD + PD, 39 cases). | 27075472 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Bioinformatical analysis and clinical verification reveal the correlation between plasma miRNAs and radiosensitivity in NSCLC patients. | 27075472 |
| Primary malignant neoplasm | Epigenetic Alterations | Blood Epigenetic Age may Predict Cancer Incidence and Mortality. | 27077113 |
| Primary malignant neoplasm | Epigenetic Alterations | Participants with smaller Dage and decelerated epigenetic aging over time had the lowest risks of cancer incidence (P = 0.003) and mortality (P = 0.02). | 27077113 |
| Primary malignant neoplasm | Epigenetic Alterations | We conclude that blood epigenetic age may mirror epigenetic abnormalities related to cancer development, potentially serving as a minimally invasive biomarker for cancer early detection. | 27077113 |
| Communicable Diseases | Epigenetic Alterations | Especially, human miRNA mir-146a expression seems to be downregulated by HCMV infection in vitro. | 27077822 |
| Hollings Cancer Center | Epigenetic Alterations | Hypermethylation of promoter regions is the main epigenetic mechanism of gene silencing and has been involved in HCC development. | 27078152 |
| Hollings Cancer Center | Epigenetic Alterations | RASSF1A and DOK1 promoter hypermethylation may be a valuable biomarker for early diagnosis of HCC and a potential molecular target for epigenetic-based therapy. | 27078152 |
| Stomach Carcinoma, Neoplasm Metastasis | Epigenetic Alterations | MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer. | 27078844 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNA) play an important role in carcinogenesis. | 27078844 |
| Stomach Carcinoma | Epigenetic Alterations | Previously, we identified miR-26b as a significantly downregulated miRNA in gastric cancer (GC) tissues (n = 106) based on differential quantitative RT-PCR (RT-qPCR) miRNA expression profiles. | 27078844 |
| Intracranial Arteriovenous Malformation, Intracranial Aneurysm | Epigenetic Alterations | Sex-dichotomous effects of NOS1AP promoter DNA methylation on intracranial aneurysm and brain arteriovenous malformation. | 27080431 |
| Neoplasms | Epigenetic Alterations | Tissues were microdissected to obtain >90% tumor or normal lung cells, subjected to miRNA transcriptome sequencing and TaqMan quantitative PCR validation. | 27081085 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | We identified known and novel, significantly over- and under-expressed (p <= 0.01 and FDR<=0.1) miRNAs in lung adenocarcinoma compared to normal lung tissue: let-7a, miR-10a, miR-15b, miR-23b, miR-26a, miR-26b, miR-29a, miR-30e, miR-99a, miR-146b, miR-181b, miR-181c, miR-421, miR-181a, miR-574 and miR-1247. | 27081085 |
| Prostate Cancer Pathway | Epigenetic Alterations | Urinary microRNA-based signature improves accuracy of detection of clinically relevant prostate cancer within the prostate-specific antigen grey zone. | 27081843 |
| Colorectal Carcinoma | Epigenetic Alterations | MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. | 27082577 |
| Primary malignant neoplasm | Epigenetic Alterations | Bioinformatics analysis showed that the DE-miRNAs were significantly enriched in cancer-associated pathways including neutrophin signaling (P = 6.84 x 10(-5)), pathways in cancer (P = 0.0016), Wnt signaling (P = 0.0027), and MAPK signaling pathway (P = 0.0036). | 27082577 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNAs (miRNAs) and transcription factors (TFs) are two major regulators of gene expression, which may play important roles in the etiology of AML. | 27082628 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | However, the global regulation of gene expression in AML, involving miRNAs and TFs, still remains elusive. | 27082628 |
| Stomach Carcinoma | Epigenetic Alterations | Furthermore, epigenetic inactivation of SLIT occurred in a gastric cancer subtype-dependent manner. | 27082735 |
| Intracranial Aneurysm | Epigenetic Alterations | MicroRNA-29a: A potential biomarker in the development of intracranial aneurysm. | 27084222 |
| Intracranial Aneurysm | Epigenetic Alterations | To identify serum microRNA-29a (miR-29a) level in patients with intracranial aneurysm and its role in the development of intracranial aneurysm (IA). | 27084222 |
| Dermoid cyst with secondary tumor | Epigenetic Alterations | Prospective validation of microRNA signatures for detecting pancreatic malignant transformation in endoscopic-ultrasound guided fine-needle aspiration biopsies. | 27086919 |
| Dermoid cyst with secondary tumor | Epigenetic Alterations | We demonstrate the feasibility of using fresh EUS-FNAs to establish miRNA-based signatures unique to pancreatic malignant transformation and the potential to enhance risk stratification and selection for surgery. | 27086919 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are potentially ideal diagnostic biomarkers, as they are stable molecules, and tumour and tissue specific. | 27086919 |
| malignant disease | Epigenetic Alterations | Validation FNA cohorts confirmed both miRNAs were overexpressed in malignant disease, while circulating miRNAs performed poorly. | 27086919 |
| Malignant Neoplasms | Epigenetic Alterations | We provide further evidence for using miRNAs as diagnostic biomarkers for pancreatic malignancy. | 27086919 |
| Primary malignant neoplasm | Epigenetic Alterations | Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer. | 27092493 |
| Primary malignant neoplasm | Epigenetic Alterations | Quantitative real-time polymerase chain reaction (qPCR) was performed on an independent set of 147 rectal cancer patients to validate relevant miRNAs. | 27092493 |
| Admitting diagnosis | Epigenetic Alterations | To understand better the epigenetic mechanisms regulating CRTC1 expression that may be altered in AD, we profiled DNA methylation at CpG site resolution by bisulfite cloning sequencing in two promoter regions (referred to as Prom1 and Prom2) of the CRTC1 gene in human hippocampus from controls and AD cases. | 27094739 |
| Admitting diagnosis | Epigenetic Alterations | DNA methylation levels within two distinct promoter regions of the CRTC1 gene were decreased in human hippocampus affected by AD compared with controls and methylation within Prom1 showed a strong inverse correlation with p-tau deposition. | 27094739 |
| Metastasis | Epigenetic Alterations | In addition, we have identified a set of SCNAs, including amplification of BRAF and ofthe epigenetic modifier EZH2, that are specific for the group of thick melanomas that developed metastasis during the follow-up. | 27095580 |
| Oropharyngeal Carcinoma | Epigenetic Alterations | The microRNA expression profiles were analyzed by micro-arrays in 26 oropharyngeal cancers. | 27097597 |
| Oropharyngeal Carcinoma | Epigenetic Alterations | A microRNA signature specific to HPV-status was identified by analyzing a learning/training set consisting of 16 oropharyngeal cancers. | 27097597 |
| Oropharyngeal Carcinoma | Epigenetic Alterations | We have identified 25 miRNA signatures, which discriminates HPV16-positive oropharyngeal cancer from their HPV-negative counterparts. | 27097597 |
| Breast Carcinoma | Epigenetic Alterations | There have been no prior studies on the question whether or not samples processed by OSNA can be used for further molecular studies, including epigenetic abnormalities which are some of the most important molecular alterations in breast cancer. | 27097811 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Expression level of microRNA-195 in the serum of patients with gastric cancer and its relationship with the clinicopathological staging of the cancer. | 27097947 |
| SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Genetic and epigenetic alterations contribute to the biological and clinical characteristics of myelodysplastic syndromes (MDS), but a role for socioeconomic environment remains unclear. | 27098194 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST. | 27100897 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA (miRNA) and long non-coding RNA (lncRNA) have been demonstrated to participate in the progression of many cancers. | 27100897 |
| Metastasis, Hollings Cancer Center | Epigenetic Alterations | Furthermore, long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) and miR-92b could directly interact with and repress each other, and XIST could inhibit HCC cell proliferation and metastasis by targeting miR-92b. | 27100897 |
| Lymphoma, Follicular, Lymphoma | Epigenetic Alterations | Prioritized alterations in epigenetic modulators were common and included gain-of-function EZH2 and loss-of-function ARID1A mutations (14% of diffuse large B-cell lymphomas and 22% of follicular lymphomas contained alterations in each of these two genes). | 27102345 |
| melanoma | Epigenetic Alterations | We have demonstrated that loss of ten-eleven translocation methylcytosine dioxygenase (TET2)-mediated 5-hydroxymethylcytosine (5-hmC) is an epigenetic driver of melanoma growth and a biomarker of clinical virulence. | 27102770 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | Dysregulated long noncoding RNAs (lncRNAs) have been found in human diseases, especially in cancer. | 27104549 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Relapse-related long non-coding RNA signature to improve prognosis prediction of lung adenocarcinoma. | 27105492 |
| Metastasis, Neoplasms | Epigenetic Alterations | Increasing evidence has highlighted the important roles of dysregulated long non-coding RNA (lncRNA) expression in tumorigenesis, tumor progression and metastasis. | 27105492 |
| Hypertensive disease | Epigenetic Alterations | The identification of these novel CpG sites may contribute to a further understanding of the epigenetic regulatory mechanisms underlying the development of essential hypertension. | 27105587 |
| nervous system disorder | Epigenetic Alterations | With ~50% of miRNAs expressing in the brain, they play an important role in neuronal development, plasticity, cognition and neurological disorders. | 27106592 |
| Neurofibromatosis 1 | Epigenetic Alterations | Is Neurofibromatosis Type 1-Noonan Syndrome a Phenotypic Result of Combined Genetic and Epigenetic Factors? | 27107091 |
| Malignant Neoplasms | Epigenetic Alterations | ACTG2 and microRNA-145 (miR-145) are aberrantly expressed in other cancers and ACTG2 can be induced by miR-145. | 27107594 |
| Metastasis, Neoplasms, Renal Cell Carcinoma Pathway | Epigenetic Alterations | MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma. | 27108693 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Consistently, overexpression of miR-126 in RCC cells significantly inhibited cell proliferation, migration and invasion in vitro compared with negative control miRNA. | 27108693 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in cancer development and progression. | 27108693 |
| Lupus Flare | Epigenetic Alterations | Epigenetic Reprogramming in Naive CD4+ T Cells Favoring T Cell Activation and Non-Th1 Effector T Cell Immune Response as an Early Event in Lupus Flares. | 27111767 |
| Lupus Erythematosus | Epigenetic Alterations | We demonstrated that naive CD4+ T cells in lupus undergo an epigenetic proinflammatory shift, implicating effector T cell responses in lupus flare. | 27111767 |
| Lupus Erythematosus | Epigenetic Alterations | Bioinformatics analyses indicate that the epigenetic modulator EZH2 might play an important role in shifting the epigenetic landscape, with increased disease activity in lupus naive CD4+ T cells. | 27111767 |
| Lupus Erythematosus | Epigenetic Alterations | Further, the expression of microRNA-26a, which is sensitive to glucose availability and targets EZH2, was negatively correlated with disease activity in lupus patients. | 27111767 |
| Stomach Carcinoma, Helicobacter pylori, Gastritis, Egyptian language | Epigenetic Alterations | Braf, Kras and Helicobacter pylori epigenetic changes-associated chronic gastritis in Egyptian patients with and without gastric cancer. | 27116958 |
| Primary malignant neoplasm | Epigenetic Alterations | H. pylori may cause epigenetic changes predisposing the patients to cancer stomach. | 27116958 |
| Prostate Cancer Pathway | Epigenetic Alterations | Novel diagnostic and prognostic classifiers for prostate cancer identified by genome-wide microRNA profiling. | 27120795 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNAs have been reported to be involved in numerous cell processes, including cell apoptosis, proliferation and migration, thus suggesting that miRNAs may have an important role in cancer progression. | 27121091 |
| Prostate Cancer Pathway | Epigenetic Alterations | Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies. | 27121847 |
| Primary malignant neoplasm | Epigenetic Alterations | Compared to other risk factors, detection of DNA-methylation in histopathologically negative biopsies was the most significant and important predictor of high-grade cancer, resulting in a NPV of 96%. | 27121847 |
| Primary malignant neoplasm | Epigenetic Alterations | Low DNA-methylation levels in PCa-negative biopsies led to a NPV of 96% for high-grade cancer. | 27121847 |
| Primary malignant neoplasm | Epigenetic Alterations | The risk score, comprising DNA-methylation intensity and traditional clinical risk factors, improved the identification of men with high-grade cancer, with a maximum avoidance of unnecessary repeat biopsies. | 27121847 |
| melanoma, Neoplasms | Epigenetic Alterations | MicroRNA-199a-5p inhibits tumor proliferation in melanoma by mediating HIF-1a. | 27122154 |
| melanoma | Epigenetic Alterations | The expression of miRNA-199a-5p (miR-199a-5p) in melanoma was detected by quantitative polymerase chain reaction on samples from 25 melanoma patients. | 27122154 |
| Initiation | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have come into focus for their important regulatory roles in fundamental biological processes, particularly in cancer initiation, development and progression. | 27122348 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA Seed Region Length Impact on Target Messenger RNA Expression and Survival in Colorectal Cancer. | 27123865 |
| Carcinoma, Clinical Coordinator, Dying Process | Epigenetic Alterations | We analyzed these groups in terms of miRNA differential expression between carcinoma and normal colorectal mucosa, differential colonic target mRNA expression, and risk of dying from CRC. | 27123865 |
| Cardiovascular Diseases | Epigenetic Alterations | Circulating microRNA has recently emerged as a promising biomarker for cardiovascular disease. | 27124025 |
| Hypoxia | Epigenetic Alterations | Hypoxia has been shown to alter DNA methylation, an epigenetic mechanism involved in regulating gene expression such as the pro-fibrotic transforming growth factor (TGF) b1 and the anti-fibrotic Ras protein activator like 1 (RASAL1). | 27124111 |
| NTM gene | Epigenetic Alterations | We found increased DNA methylation, increased TGFb1 expression and decreased RASAL1 expression in GTM cells compared to NTM cells. | 27124111 |
| NTM gene | Epigenetic Alterations | TGFb1 and RASAL1 expression, global DNA methylation, and expression of associated methylation enzymes were altered between NTM and GTM cells. | 27124111 |
| Glaucoma, CTCAE | Epigenetic Alterations | Furthermore, DNA methylation, TGFb1 and RASAL1 appear to have an interacting relationship that may play a role in driving pro-fibrotic disease progression in the glaucomatous TM. | 27124111 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Markers of epigenetic aberrations have shown promising results in several cancer types and can be assessed by automatic analysis of chromatin organisation in tumour cell nuclei. | 27124335 |
| Primary malignant neoplasm | Epigenetic Alterations | We analyzed the relationship between multivariable molecular data and LTS in GBM patients from the Cancer Genome Atlas (TCGA), including germline and somatic point mutation, gene expression, DNA methylation, copy number variation (CNV) and microRNA (miRNA) expression using logistic regression models. | 27124395 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Development of a deregulating microRNA panel for the detection of early relapse in postoperative colorectal cancer patients. | 27126129 |
| Clinical Coordinator | Epigenetic Alterations | MicroRNA (miR) deregulation is associated with CRC development and recurrence; therefore, miRs may be reliable biomarkers for detecting early relapse postoperatively. | 27126129 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Serum microRNA-135a-5p as an auxiliary diagnostic biomarker for colorectal cancer. | 27126269 |
| Diabetes Mellitus | Epigenetic Alterations | Micro-RNA-126 Reduces the Blood Thrombogenicity in Diabetes Mellitus via Targeting of Tissue Factor. | 27127202 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Prognostic impact of epigenetic classification in chronic lymphocytic leukemia: The case of subset #2. | 27128508 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Based on the methylation status of 5 single CpG sites, a novel epigenetic classification of chronic lymphocytic leukemia (CLL) was recently proposed, classifying CLL patients into 3 clinico-biological subgroups with different outcome, termed memory like CLL (m-CLL), naive like CLL (n-CLL), and a third intermediate CLL subgroup (i-CLL). | 27128508 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | In summary, we validated the epigenetic classifier as an independent factor in CLL prognostication and provide further evidence that subset #2 is a member of the i-CLL group, hence supporting the existence of a third, intermediate epigenetic subgroup. | 27128508 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis. | 27130667 |
| Malignant Neoplasms, Malignant neoplasm of urinary bladder | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been suggested to play important roles in the progression of many cancers such as bladder cancer. | 27130667 |
| Psoriasis | Epigenetic Alterations | There are no published studies that describe the DNA methylation of human leukocyte antigen class I molecules in psoriasis despite the fact that their association to disease has been known for several decades. | 27132688 |
| Psoriasis | Epigenetic Alterations | Hypermethylation of HLA-C may be an epigenetic marker in psoriasis. | 27132688 |
| Psoriasis | Epigenetic Alterations | We first demonstrate hypermethylation of HLA-C gene in psoriatic epidermis, suggesting that HLA-C hypermethylation may be an epigenetic marker in psoriasis. | 27132688 |
| Neoplasms | Epigenetic Alterations | A combined clinical, genetic, and epigenetic model for detecting synchronous neoplasm by testing of non-neoplastic colonic tissue had favorable operating characteristics and could complement current patient care. | 27135485 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | RUNX1 mutations were found in 245 of 2439 (10%) patients; were almost mutually exclusive of AML with recurrent genetic abnormalities; and they co-occurred with a complex pattern of gene mutations, frequently involving mutations in epigenetic modifiers (ASXL1, IDH2, KMT2A, EZH2), components of the spliceosome complex (SRSF2, SF3B1) and STAG2, PHF6, BCOR. | 27137476 |
| Prostatic Neoplasms | Epigenetic Alterations | Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. | 27142338 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | DNA methylation has been hypothesized as a mechanism for explaining the association between smoking and adverse prostate cancer (PCa) outcomes. | 27142338 |
| CHOANAL ATRESIA, POSTERIOR, Neoplasms | Epigenetic Alterations | A total of 523 men had radical prostatectomy as their primary treatment, detailed smoking history data, long-term follow-up for PCa outcomes, and tumor tissue profiled for DNA methylation. | 27142338 |
| Neoplasms | Epigenetic Alterations | This integrative molecular epidemiology study supports the hypothesis that smoking-associated tumor DNA methylation changes may explain at least part of the association between smoking and adverse PCa outcomes. | 27142338 |
| Carcinogenesis, Epstein-Barr virus associated gastric carcinoma | Epigenetic Alterations | A systemic profiling of ebv-miRNAs expressed in EBV-associated gastric carcinoma (EBVa GC) helps understand its epigenetic regulation of carcinogenesis. | 27144885 |
| Neoplasms | Epigenetic Alterations | Comprehensive profiling of virus microRNAs of Epstein-Barr virus-associated gastric carcinoma: highlighting the interactions of ebv-Bart9 and host tumor cells. | 27144885 |
| Neoplastic disease | Epigenetic Alterations | Epstein-Barr virus (EBV) is suggested to actively utilize its ebv-microRNAs (miRNAs) to manipulate viral and cellular functions during neoplasia transformation. | 27144885 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Recently, growing evidence has indicated that deregulation of microRNAs (miRNAs) contributes to tumorigenesis and tumor progression in colorectal cancer (CRC). | 27145368 |
| precancerous lesions, Colorectal Traditional Serrated Adenoma | Epigenetic Alterations | To clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we assessed the DNA methylation of cancer-associated genes in a cohort of BRAF-mutant precancerous lesions from 94 individuals. | 27145369 |
| Colorectal | Epigenetic Alterations | Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations. | 27145369 |
| Primary malignant neoplasm | Epigenetic Alterations | Common single nucleotide polymorphisms (SNPs) in miRNAs may affect miRNA functions and their target expression and thus may affect biological activities and cancer etiology as well as prognosis. | 27145460 |
| Hepatitis C, Virus Diseases, Hepatobiliary Disorder | Epigenetic Alterations | Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis. | 27147737 |
| Virus Diseases | Epigenetic Alterations | While host miRNAs are essential for HCV replication, viral infection in turn appears to induce alterations of intrahepatic miRNA networks. | 27147737 |
| Hepatobiliary Disorder, Primary malignant neoplasm | Epigenetic Alterations | miRNA expression is known to be deregulated in liver disease and cancer. | 27147737 |
| Communicable Diseases | Epigenetic Alterations | Furthermore, miRNAs are essential for HCV replication, and HCV infection alters miRNA expression. | 27147737 |
| Hepatobiliary Disorder, Hollings Cancer Center | Epigenetic Alterations | MicroRNAs (miRNAs) play an important role in homeostasis within the liver, and deregulation of miRNAs has been associated with liver disease, including HCC. | 27147737 |
| Hepatobiliary Disorder, Hollings Cancer Center | Epigenetic Alterations | Although the cross talk between HCV and liver cell miRNAs most likely contributes to liver disease pathogenesis, the functional involvement of miRNAs in HCV-driven hepatocyte injury and HCC remains elusive. | 27147737 |
| Injury of liver, Carcinogenesis | Epigenetic Alterations | Here we show that HCV induces miRNAs that may contribute to liver injury and carcinogenesis. | 27147737 |
| Nasopharyngeal carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-23b regulates nasopharyngeal carcinoma cell proliferation and metastasis by targeting E-cadherin. | 27150436 |
| Metastasis, Neoplasms | Epigenetic Alterations | MicroRNA-23b (miR-23b) is important in tumor proliferation and metastasis. | 27150436 |
| Chronic liver disease, Fibrosis Assessment | Epigenetic Alterations | Genetic variants and environmental cues influence predisposition to the development of chronic liver disease; however, it remains unknown if aberrant DNA methylation is associated with fibrosis progression in chronic hepatitis B. | 27152124 |
| Chronic liver disease, Hepatitis | Epigenetic Alterations | To identify epigenetic marks associated with inflammatory and fibrotic processes of the hepatitis B-induced chronic liver disease, we carried out hepatic genome-wide methylation profiling using Illumina Infinium BeadArrays comparing mild and severe fibrotic disease in a discovery cohort of 29 patients. | 27152124 |
| Hepatitis B | Epigenetic Alterations | Our findings suggest a linkage of widespread epigenetic dysregulation with disease progression in chronic hepatitis B infection. | 27152124 |
| Breast Carcinoma | Epigenetic Alterations | A Set of miRNAs, Their Gene and Protein Targets and Stromal Genes Distinguish Early from Late Onset ER Positive Breast Cancer. | 27152840 |
| Mammary Neoplasms | Epigenetic Alterations | We proposed that differentially expressed miRNAs could regulate genes and proteins underlying aggressive phenotypes of breast tumors in YA patients when compared to those arising in MA patients. | 27152840 |
| Malignant neoplasm of breast, Aggressive behavior | Epigenetic Alterations | We defined a set of differentially expressed miRNAs, their mRNAs and protein targets and stromal genes that distinguish early onset from late onset ER positive breast cancers which may be involved with tumor aggressiveness of YA-BC. | 27152840 |
| Small cell carcinoma of lung | Epigenetic Alterations | Prognostic impact of a 3-MicroRNA signature in cytological samples of small cell lung cancer. | 27153322 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA (miRNA) signatures have been recently proposed as useful biomarkers in lung cancer because of their high stability during standard sample processing. | 27153322 |
| Small cell carcinoma of lung | Epigenetic Alterations | A specific 3-miRNA signature is potentially useful for predicting survival for patients with SCLC, and it may be feasible with cytological samples taken during standard diagnostic procedures. | 27153322 |
| Muscular Dystrophy, Facioscapulohumeral | Epigenetic Alterations | Mutations in DNMT3B Modify Epigenetic Repression of the D4Z4 Repeat and the Penetrance of Facioscapulohumeral Dystrophy. | 27153398 |
| Muscular Dystrophy, Facioscapulohumeral | Epigenetic Alterations | This study suggests that transcription of DUX4 in somatic cells is modified by variations in its epigenetic state and provides a basis for understanding the reduced penetrance of FSHD within families. | 27153398 |
| Multiple Myeloma | Epigenetic Alterations | Identification of a novel microRNA, miR-4449, as a potential blood based marker in multiple myeloma. | 27155004 |
| Primary malignant neoplasm | Epigenetic Alterations | miRNAs act in diverse biological processes including development, cell growth, apoptosis, and hematopoiesis, suggesting their role in cancer. | 27155004 |
| Asthma | Epigenetic Alterations | We sought to associate miRNA expression in sputum supernatants with the inflammatory cell profile and disease severity in asthmatic patients. | 27155035 |
| Asthma | Epigenetic Alterations | Differentially expressed miRNAs were validated in an independent cohort (n = 60; 10 healthy subjects and 50 asthmatic patients). | 27155035 |
| Neutrophilia (finding), Airway Obstruction | Epigenetic Alterations | Expression of the 3 miRNAs was associated with sputum neutrophilia, and miR-223-3p and miR-142-3p expression was associated also with airway obstruction (FEV1/forced vital capacity). | 27155035 |
| Asthma Pathway, Airway structure | Epigenetic Alterations | Expression of miR-223-3p, miR-142-3p, and miR-629-3p is increased in sputum of patients with severe asthma and is linked to neutrophilic airway inflammation, suggesting that these miRNAs contribute to this asthma inflammatory phenotype. | 27155035 |
| Huntington Disease, Impaired | Epigenetic Alterations | Circulating microRNAs in Huntingtons disease: Emerging mediators in metabolic impairment. | 27155059 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Improved Noninvasive Bladder Cancer Diagnosis using Urine Sediments and Novel DNA Methylation Biomarker Panels. | 27156320 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation status early in carcinogenesis represents a potential indicator of tumor detection. | 27156320 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | We would like to establish a DNA methylation biomarker panel for bladder cancer detection in the research. | 27156320 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Using the urine of bladder cancer patients and healthy controls, we assessed several novel DNA methylation biomarker panels that demonstrated good bladder cancer detection capability. | 27156320 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Expression Level of Urinary MicroRNA-146a-5p Is Increased in Patients With Bladder Cancer and Decreased in Those After Transurethral Resection. | 27157639 |
| Primary malignant neoplasm | Epigenetic Alterations | We identified 3 miRNAs (miR-301b, -563, and -146a-5p) that demonstrated > 2-fold higher expression levels in cancer cell lines than in the normal ureteral epithelial tissue. | 27157639 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Epigenetic modifications, including DNA methylation of tumor suppressor genes carried out by DNA methyltransferases (DNMTs), are important events in carcinogenesis. | 27159259 |
| Prostate Cancer Pathway | Epigenetic Alterations | MicroRNA (miRNA) has been shown to be associated with the initiation and progression of prostate cancer. | 27164937 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway | Epigenetic Alterations | Genome-wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis. | 27165481 |
| Clinical Coordinator, Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | The liver is the most frequent site of metastasis in colorectal cancer (CRC), in which long noncoding RNAs (lncRNAs) may play a crucial role. | 27165481 |
| Primary malignant neoplasm | Epigenetic Alterations | Background MicroRNAs have been implicated in many biological pathways involved in tumourigenesis and can serve as prognostic biomarkers in many cancer types. | 27166306 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-21 is overexpressed in most cancers and has been implicated in tumorigenesis. | 27166999 |
| Neoplasms | Epigenetic Alterations | A microRNA (miRNA) that functionally downregulates the expression of tumor suppressors can be defined as an oncomir. | 27167185 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Serum microRNA expression signatures as novel noninvasive biomarkers for prediction and prognosis of muscle-invasive bladder cancer. | 27167342 |
| Dementia | Epigenetic Alterations | Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia. | 27167582 |
| Dementia | Epigenetic Alterations | Epigenetics (particularly DNA methylation) together with environmental and genetic factors, are key to understanding the pathogenesis of many diseases including dementia. | 27167582 |
| Dementia | Epigenetic Alterations | Disturbances in DNA methylation have already been implicated in dementia. | 27167582 |
| Dementia, Vascular | Epigenetic Alterations | A non-significant tendency to higher DNA methylation in patients with vascular dementia (p=0.061) was observed. | 27167582 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Our studies of microRNA (miRNA) expression signatures have shown that microRNA-1 (miR-1) and microRNA-206 (miR-206) were downregulated in head and neck squamous cell carcinoma (HNSCC) clinical specimens. | 27169691 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | The seed sequences of these miRNAs are identical, suggesting that the identification of the molecular targets regulated by miR-1 and miR-206 will provide new insights into novel mechanisms of HNSCC pathogenesis. | 27169691 |
| Neoplasms | Epigenetic Alterations | This miRNA was up-regulated in high grade (P=0.041), the TMPRSS2-ERG fusion-positive tumors (P=0.026), and in patients with subsequently developed biochemical recurrence (BCR; P=0.054) after radical prostatectomy. | 27170485 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | In PCa, the diagnostic potential of urinary miRNA panel (miR-21, miR-19a, and miR-19b) was higher than that of the PSA test (AUC=0.738 vs. AUC=0.514). | 27170485 |
| Prostate Cancer Pathway | Epigenetic Alterations | Detection of miRNAs in urine of prostate cancer patients. | 27170485 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | MiRNAs highly expressed in PCa tissues were also detectable in urine from PCa patients. | 27170485 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Measurement of urinary levels of PCa-specific miRNAs could assist in more specific detection of PCa and prediction of BCR. | 27170485 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic deregulation is considered as a new hallmark of cancer. | 27172249 |
| Malignant Neoplasms, Breast Carcinoma | Epigenetic Alterations | The long non-coding RNA MALAT1 has been implicated in several cancers; however, its role in breast cancer is still little known. | 27172249 |
| Endothelial dysfunction | Epigenetic Alterations | Low levels of sCD40L 1 month after PCI distinguish STEMI patients with worse prognosis, a compromised cardiac healing, and a persistent endothelial dysfunction, as given by the association between sCD40L, NT-proBNP, G894T polymorphism, and specific profile of miRNA expression. | 27172386 |
| Hypertrophic Cardiomyopathy | Epigenetic Alterations | Lower quartiles of sCD40L (<2.3 ng/mL) were associated with higher concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP), high frequency of G894T polymorphism, and altered expression of a set of microRNAs assumed to be involved in the regulation of endothelial and cardiac function and myocardium hypertrophy, relative to patients in sCD40L upper quartiles. | 27172386 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA 141 Expression Is a Potential Prognostic Marker of Biliary Tract Cancers. | 27172928 |
| Liver and Intrahepatic Biliary Tract Carcinoma | Epigenetic Alterations | Overexpression of miRNA 141 is an indicator of a poor prognosis in patients with biliary tract cancer, suggesting that miRNA 141 may be a valuable prognostic biomarker of this disease. | 27172928 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | In recent years, a large number of microribonucleic acids (miRNAs) have been identified as putative prognostic biomarkers for solid cancers because of their role in controlling the expression of oncogenes and tumor suppressor genes. | 27172928 |
| Malignant Neoplasms | Epigenetic Alterations | Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. | 27173192 |
| Prostate Cancer Pathway | Epigenetic Alterations | Prediction efficiency of PITX2 DNA methylation for prostate cancer survival. | 27173224 |
| Neoplasms | Epigenetic Alterations | A higher degree of PITX2 DNA methylation was associated with higher tumor stage and lower survival rates. | 27173224 |
| Prostate Cancer Pathway | Epigenetic Alterations | PITX2 DNA methylation presents a good predictive value for prostate cancer survival. | 27173224 |
| Stomach Carcinoma | Epigenetic Alterations | Deregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC). | 27173244 |
| Stomach Carcinoma | Epigenetic Alterations | Identification and functional characterization of microRNAs reveal a potential role in gastric cancer progression. | 27173517 |
| Tetranitromethane, Metastasis, Neoplasms | Epigenetic Alterations | 22 GC specific key miRNAs were identified (Fold-change >2, P < 0.05), 11 of them were discriminatively expressed with tumor size, grade, TNM stage and lymphatic metastasis (P < 0.05). | 27173517 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Age-dependent epigenetic alterations or other somatic changes might collaborate with the mutation to cause AML. | 27174803 |
| Malignant Neoplasms | Epigenetic Alterations | Certain microRNAs (miRs) are implicated in the genesis and progression of various cancers by regulating multiple cellular processes, including apoptosis, proliferation and migration. | 27175581 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | MicroRNA-126 is downregulated in thyroid cancer cells, and regulates proliferation, migration and invasion by targeting CXCR4. | 27175968 |
| Esophageal carcinoma | Epigenetic Alterations | To the best of our knowledge, this is the first report describing DNA methylation-mediated silencing of miR-193b in esophageal cancer and BE tissues. | 27176876 |
| Barrett Esophagus | Epigenetic Alterations | Aberrant methylation of microRNA-193b in human Barretts esophagus and esophageal adenocarcinoma. | 27176876 |
| Glioblastoma Multiforme | Epigenetic Alterations | The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients. | 27176932 |
| Inflammation | Epigenetic Alterations | Our results suggest that epigenetic changes participate in chronic inflammation and aging in the palatine tonsils. | 27180790 |
| Breast Carcinoma | Epigenetic Alterations | microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection. | 27180809 |
| Columnar Metaplasia, Communicable Diseases | Epigenetic Alterations | DNA methylation occurs in cases of gastric-type (non-specialized) columnar metaplasia of the esophagus, and this modification is associated with H. pylori cagA positive infection. | 27182166 |
| Triple-Negative Breast Cancer Finding, Neoplasms | Epigenetic Alterations | Long-term soy consumption and tumor tissue MicroRNA and gene expression in triple-negative breast cancer. | 27183356 |
| Neoplasms | Epigenetic Alterations | A total of 14 miRNAs and 24 genes were significantly associated with soy food intake (P < .05): Thirteen of the 14 miRNAs (92.9%) and 9 of the 24 genes (37.5%), including tumor suppressors miR-29a-3p and IGF1R, showed overexpression for those women with high soy intake, whereas the remaining miRNAs and genes, including oncogenes KRAS and FGFR4, showed underexpression. | 27183356 |
| Skeletal muscle structure | Epigenetic Alterations | Our results provide insights into the potential regulatory role of epigenetic histone acetylation of the miR-449a promoter that may regulate its expression in the diabetic skeletal muscle. | 27184529 |
| Esophageal carcinoma | Epigenetic Alterations | MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. | 27188433 |
| Disease | Epigenetic Alterations | Increasing evidence shows that single nucleotide polymorphisms (SNPs) or mutations in miRNAs sequence may affect the processing and function of miRNAs and participate in the occurrence of diseases. | 27188998 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNAs associated with increased AKT gene number in human lung carcinoma. | 27189341 |
| Gastric Cardia Adenocarcinoma | Epigenetic Alterations | Methylation-mediated downregulation of long noncoding RNA LOC100130476 in gastric cardia adenocarcinoma. | 27189370 |
| Carcinogenesis, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidences indicate that long non-coding RNAs (lncRNAs) play important roles in several biological processes and dysregulated lncRNAs are involved in different kinds of cancer and are associated with carcinogenesis, metastasis, and prognosis of cancer. | 27189370 |
| Breast Cancer Cell, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (Malat1) functions as an oncogene in many types of human cancer. | 27191262 |
| Malignant tumor of colon | Epigenetic Alterations | microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway. | 27191497 |
| Neoplasms | Epigenetic Alterations | microRNA-374a (miR-374a) exhibits oncogenic functions in various tumor types. | 27191497 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer. | 27191990 |
| Carcinoma of lung, Chronic Obstructive Airway Disease | Epigenetic Alterations | The purpose of this study was to identify circulating microRNAs for detection of early stage lung cancer, capable of discriminating lung cancer patients from those with chronic obstructive pulmonary disease (COPD) and healthy volunteers. | 27191990 |
| Carcinoma of lung | Epigenetic Alterations | We identified 7 microRNAs separating lung cancer patients from controls. | 27191990 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | By using RT-qPCR, we validated 6 microRNAs (miR-429, miR-205, miR-200b, miR-203, miR-125b and miR-34b) with a significantly higher abundance in serum from NSCLC patients. | 27191990 |
| Hollings Cancer Center | Epigenetic Alterations | Moreover, we found that miR-129-2 was downregulated by DNA methylation, and demethylation of miR-129-2 increased miR-129-2 expression in HCC cells and resulted in significant inhibitory effects on cell migration and invasion. | 27191994 |
| Aggressive behavior, Liver carcinoma | Epigenetic Alterations | Methylation-mediated repression of microRNA-129-2 suppresses cell aggressiveness by inhibiting high mobility group box 1 in human hepatocellular carcinoma. | 27191994 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant expression of microRNAs (miRNAs) and its dysfunction have been revealed as crucial modulators of cancer initiation and progression. | 27191994 |
| Mucosal Melanoma, Malignant melanoma of conjunctiva | Epigenetic Alterations | In addition, very little is known about the genetic and epigenetic profile of conjunctival melanoma and the resemblance to uveal, cutaneous and mucosal melanoma. | 27192168 |
| Malignant melanoma of conjunctiva, melanoma | Epigenetic Alterations | Finally, we wanted to identify tumour-specific and prognostic microRNAs in conjunctival melanoma, and to compare these with the microRNA expression of other melanoma subtypes. | 27192168 |
| Malignant melanoma of conjunctiva | Epigenetic Alterations | MicroRNA expression analysis revealed 25 tumour-specific microRNAs in conjunctival melanoma. | 27192168 |
| Neoplasms | Epigenetic Alterations | Seven microRNAs (miR-30d-5p, miR-138-5p, miR-146a-5p, miR-500a-5p, miR-501-3p, miR-501-5p and miR-502-3p) were significantly and simultaneously up-regulated in both stage T1 and stage T2 tumours, and were associated with increased tumour thickness. | 27192168 |
| Mucosal Melanoma, Malignant melanoma of conjunctiva | Epigenetic Alterations | The expression of the 25 tumour-specific microRNAs did not differ significantly between conjunctival melanoma and oral or nasal mucosal melanoma. | 27192168 |
| Uveal melanoma, Mucosal Melanoma, Malignant melanoma of conjunctiva | Epigenetic Alterations | From our findings of a distinct pattern of BRAF mutations and differentially expressed microRNAs, it is evident that conjunctival melanoma is closely related to cutaneous and other mucosal melanomas and bears less resemblance to uveal melanomas. | 27192168 |
| Malignant melanoma of conjunctiva | Epigenetic Alterations | Additionally, the identification of several up-regulated microRNAs may prove to be useful as prognostic or therapeutic targets in conjunctival melanoma. | 27192168 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | The extent of DNA methylation in the AAA patients was negatively correlated with the corresponding aortic diameter (r = -0.498, p < 0.0001). | 27194055 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Abnormal Epigenetic Modifications in Peripheral T Cells from Patients with Abdominal Aortic Aneurysm Are Correlated with Disease Development. | 27194055 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells. | 27195672 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Recently, long non-coding RNAs (lncRNAs) are identified as new crucial regulators of diverse cellular processes, including cell proliferation, differentiation and cancer cells metastasis. | 27195672 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Long intergenic noncoding RNAs (lincRNAs) have important roles in biological functions, molecular mechanisms and prognostic values in colorectal cancer (CRC). | 27195675 |
| Prostate Cancer Pathway | Epigenetic Alterations | Impact of Genetic and Epigenetic Variations Within the FADS Cluster on the Composition and Metabolism of Polyunsaturated Fatty Acids in Prostate Cancer. | 27197070 |
| Deep thrombophlebitis, Thrombophilia | Epigenetic Alterations | In conclusions, these findings indicate that certain miRNAs are associated with DVT and markers of hypercoagulability, though their diagnostic abilities are probably too low. | 27197074 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Distinct alterations in the DNA methylation of the gene regions encoding TGFb pathway components were detected in NSCLC samples compared with tumor-free lung tissues. | 27197161 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | In particular, epigenetic silencing of BAMBI was identified as a hallmark of NSCLC. | 27197161 |
| Neoplasms | Epigenetic Alterations | Colorectal tumor molecular phenotype and miRNA: expression profiles and prognosis. | 27198570 |
| Neoplasms | Epigenetic Alterations | In this paper, we test the hypotheses that miRNA expression differs by tumor molecular phenotype and that those differences may influence prognosis. | 27198570 |
| Neoplasms | Epigenetic Alterations | We assessed differences in miRNA expression between TP53-mutated and non-mutated, KRAS-mutated and non-mutated, BRAF-mutated and non-mutated, CpG island methylator phenotype (CIMP) high and CIMP low, and microsatellite instability (MSI) and microsatellite stable (MSS) colon and rectal tumors. | 27198570 |
| Neoplasms | Epigenetic Alterations | It has been proposed that unique miRNAs influence specific tumor molecular phenotype. | 27198570 |
| Neoplasms | Epigenetic Alterations | Additionally, 13 miRNAS were differentially expressed for KRAS-mutated rectal tumors, 8 differentially expressed miRNAs for colon CIMP high tumors, and 2 differentially expressed miRNAs for BRAF-mutated colon tumors. | 27198570 |
| Neoplasms | Epigenetic Alterations | The majority of differentially expressed miRNAS were observed between MSI and MSS tumors (94 differentially expressed miRNAs for colon; 41 differentially expressed miRNAs for rectal tumors). | 27198570 |
| Neoplasms | Epigenetic Alterations | Of these miRNAs differentially expressed between MSI and MSS tumors, the majority were downregulated. | 27198570 |
| Neoplasms | Epigenetic Alterations | In summary, it appears that the majority of miRNAs that are differentially expressed by tumor molecular phenotype are MSI tumors. | 27198570 |
| Benign Paroxysmal Positional Vertigo | Epigenetic Alterations | We conclude that BPPV treatment might involve some epigenetic regulations through the mediation of miR-34a, SIRT1 functions and repression of redox status. | 27203679 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Up-regulation of long non-coding RNA PANDAR is associated with poor prognosis and promotes tumorigenesis in bladder cancer. | 27206339 |
| Malignant Neoplasms | Epigenetic Alterations | PANDAR (promoter of CDKN1A antisense DNA damage activated RNA) is a novel long non-coding RNA that acts as a potential biomarker and involves in development of multiple cancers. | 27206339 |
| Neoplasms | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have emerged as biomarkers and important regulators of tumor development and progression. | 27206339 |
| Neoplasms | Epigenetic Alterations | Accordingly, treatment of tumor cells with inhibitors of DNA methylation reversed resistance to PML-induced senescence. | 27206849 |
| Primary malignant neoplasm | Epigenetic Alterations | A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence. | 27206849 |
| Neoplasms | Epigenetic Alterations | Taken together, our findings highlight a potentially valuable feature of CDK4/6 inhibitors as epigenetic modulators to facilitate activation of senescence programs in tumor cells. | 27206849 |
| Squamous cell carcinoma, SERPINB3 wt Allele, Neoplasms | Epigenetic Alterations | Evaluation of miRNA-expression and clinical tumour parameters in oral squamous cell carcinoma (OSCC). | 27210505 |
| SERPINB3 wt Allele, Neoplasms | Epigenetic Alterations | miRNA extraction from FFPE samples functioned well for OSCC, and several miRNAs were differently expressed in tumours compared with non-tumorous tissue (i.e., miR-99*; miR-224; miR-205*), indicating their possible utility as biomarkers. | 27210505 |
| Prostate Cancer Pathway | Epigenetic Alterations | Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer. | 27212625 |
| Hormone refractory prostate cancer, Primary malignant neoplasm | Epigenetic Alterations | Our miRNA expression signature in castration-resistant prostate cancer (CRPC) revealed that microRNA-320a (miR-320a) was significantly reduced in cancer tissues, suggesting that miR-320a may be a promising anticancer miRNA. | 27212625 |
| Admitting diagnosis | Epigenetic Alterations | Our data implicate dysregulation of miRNA methylation as contributor to the pathogenesis of AD. | 27213057 |
| melanoma, Neoplasms | Epigenetic Alterations | Of special interest in our series is the high incidence of male predominance (79%) in cases of thin metastasing melanoma (14%), implicating genetic or epigenetic (hormonal) gender differences underlying tumour progression. | 27213536 |
| Pulmonary arterial hypertension | Epigenetic Alterations | MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension. | 27214554 |
| Carcinogenesis, Glioblastoma Multiforme Pathway | Epigenetic Alterations | As a class of small non-coding RNAs, microRNAs (miRNAs) may be closely involved in carcinogenesis and might also be connected with glioma diagnosis and prognosis. | 27215622 |
| ovarian neoplasm | Epigenetic Alterations | Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution. | 27216078 |
| Carcinogenesis | Epigenetic Alterations | The exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear. | 27216078 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic reprogramming is an early pre-malignant event integral to BRCA1/2 mutation-driven carcinogenesis. | 27216078 |
| Carcinoma, Transitional Cell, Kidney Diseases | Epigenetic Alterations | MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy. | 27218105 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrantly expressed miRNAs have been shown to be associated with many types of cancers. | 27218105 |
| Failure | Epigenetic Alterations | Epigenetic silencing of GSTM2 and MYCL2 comprise novel molecular markers to predict BCR after surgery for medium- and high-risk localized PCa undergoing surgical treatment and hypermethylation of these genes could be incorporated to the clinical and pathological factors defining the patient at higher risk of PSA failure after prostatectomy. | 27220660 |
| Huntington Disease | Epigenetic Alterations | Altered Expression of the Long Noncoding RNA NEAT1 in Huntingtons Disease. | 27221610 |
| Hodgkin Disease, neuron death | Epigenetic Alterations | Growing evidence supports the regulatory functions of long noncoding RNAs (lncRNAs) in the disease process, but little is known about the association between lncRNAs and neuronal death in HD. | 27221610 |
| Breast Carcinoma | Epigenetic Alterations | Circulating Cell-free miRNA Expression and its Association with Clinicopathologic Features in Inflammatory and Non- Inflammatory Breast Cancer. | 27221856 |
| Primary malignant neoplasm | Epigenetic Alterations | Polymorphisms affecting microRNA (miRNA) biogenesis or mRNA:miRNA interactions are important risk factors in the development of different types of cancer. | 27221928 |
| Metastasis, Neoplasms | Epigenetic Alterations | Several long non-coding RNAs (lncRNAs) have been identified that may have a crucial role in tumor progression and metastasis. | 27222255 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Downregulation of lncRNA CASC2 by microRNA-21 increases the proliferation and migration of renal cell carcinoma cells. | 27222255 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | MicroRNA-21 (miR-21) has been reported to be upregulated in human RCC tissues and cell lines, and is associated with the malignant progression of RCC. | 27222255 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Although the role of traditional risk factors for type 2 diabetes, such as genetic, lifestyle, and behavioral risk factors, has been given attention, recent research has focused on identifying the contributions of epigenetic mechanisms and the effect of the intrauterine environment. | 27222545 |
| Neoplasms | Epigenetic Alterations | MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1. | 27223073 |
| Malignant Neoplasms, Metastasis | Epigenetic Alterations | MicroRNA (miR)-138 was found to have suppressive effects on the growth and metastasis of different human cancers. | 27223073 |
| Sarcoma, Sarcoma, Epithelioid | Epigenetic Alterations | Epigenetic regulation of SMARCB1 By miR-206, -381 and -671-5p is evident in a variety of SMARCB1 immunonegative soft tissue sarcomas, while miR-765 appears specific for epithelioid sarcoma. | 27223121 |
| Neoplasms | Epigenetic Alterations | A subset of ESs (5/51) showed biallelic deletion of SMARCB1 with no overexpression of any miRNA, suggesting these tumors could be the counterpart of pediatric RT, at least genetically. | 27223121 |
| Adenocarcinoma, Neoplasms | Epigenetic Alterations | Gene and MicroRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated With Preoperative Chemoradiotherapy. | 27225591 |
| Septicemia | Epigenetic Alterations | Diagnostic value of elevated serum miRNA-143 levels in sepsis. | 27225861 |
| SRC gene | Epigenetic Alterations | Furthermore, bFGF inhibited microRNA-381 expression via the PDGFR and c-Src cascade. | 27229532 |
| Malignancy-associated membranous nephropathy, Breast Carcinoma | Epigenetic Alterations | The potential of identification of a malignancy-associated biomarker in breast cancer diagnosis and research: hTERT gene DNA methylation. | 27229911 |
| Carcinoma of lung | Epigenetic Alterations | Associations between genetic variants located in mature microRNAs and risk of lung cancer. | 27232940 |
| Colorectal Cancer Pathway, HLA Mismatch, MLH1 gene | Epigenetic Alterations | Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). | 27234654 |
| MLH1 gene | Epigenetic Alterations | rs868 is contained in a let-7 miRNA binding site in the 3UTR of TGFBR1, which might provide a functional basis for the association in MSS HNPCC. | 27234654 |
| Multiple Myeloma | Epigenetic Alterations | Epigenetic dysregulation is known to be an important contributor to myeloma pathogenesis but, unlike other B-cell malignancies, the full spectrum of somatic mutations in epigenetic modifiers has not been reported previously. | 27235425 |
| Multiple Myeloma | Epigenetic Alterations | Numerous mutations identified raise the possibility of targeted treatment strategies for patients either at diagnosis or relapse supporting the use of sequencing-based diagnostics in myeloma to help guide therapy as more epigenetic targeted agents become available. | 27235425 |
| Breast Carcinoma | Epigenetic Alterations | The dysregulation of miRNA expression has frequently been observed in breast cancer. | 27236032 |
| Breast Carcinoma | Epigenetic Alterations | Expression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer. | 27236032 |
| Breast Carcinoma | Epigenetic Alterations | The expression levels of the miRNAs and FHIT were downregulated in breast cancer tissue. | 27236032 |
| Malignant Neoplasms | Epigenetic Alterations | Our data suggest that VWF:Ag could be a circulating biomarker of disease malignancy, that could be considered, in association with other genetic and epigenetic factors, currently available in the GBM management. | 27236861 |
| Cessation of life | Epigenetic Alterations | Effect of microRNA-21 on the proliferation of human degenerated nucleus pulposus by targeting programmed cell death 4. | 27240294 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer. | 27245242 |
| Carcinogenesis, Adenoma | Epigenetic Alterations | Aberrant DNA methylation appears already in adenomas as an early event of colorectal carcinogenesis. | 27245242 |
| Carcinogenesis | Epigenetic Alterations | The WNT signaling pathway has an essential role in colorectal carcinogenesis and progression, which involves a cascade of genetic and epigenetic changes. | 27245242 |
| Stomach Carcinoma | Epigenetic Alterations | Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression. | 27246976 |
| Malignant Neoplasms, Stomach Carcinoma, Disease | Epigenetic Alterations | Recently, long noncoding RNAs have been emerged as critical regulators of human disease and prognostic markers in several cancers, including gastric cancer. | 27246976 |
| Neoplasms | Epigenetic Alterations | Our results propose that HSP60 silencing disrupts the integrity of the respiratory complex I and triggers the excessive ROS production, which promotes tumor progression in the following aspects: (1) ROS activates the AMPK pathway that promotes acquisition of the Warburg phenotype in HSP60-KN cells; (2) ROS generated by HSP60 knockdown or by rotenone inhibition drives cells to undergo EMT; and (3) the high level of ROS may also fragment the Fe-S clusters that up regulates ADHFe1 expression and the 2-hydroxygluterate (2-HG) production leading to changes in DNA methylation. | 27246978 |
| Stage II Colon Cancer AJCC v7 | Epigenetic Alterations | Identifying High-Risk Stage II Colon Cancer Patients: A Three-MicroRNA-Based Score as a Prognostic Biomarker. | 27247088 |
| Malignant tumor of colon | Epigenetic Alterations | Our 3-miRNA score added valuable prognostic information to the clinical features in stage II colon cancer. | 27247088 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) have previously been shown to be useful cancer biomarkers. | 27247088 |
| Degenerative polyarthritis | Epigenetic Alterations | Previously, it was reported that the inhibition of microRNA-34a (miR-34a) may reduce rat chondrocyte apoptosis induced by IL-1b, whereas the molecular mechanism and the role of miR-34a in human chondrocyte as well as in OA progression remains to be determined. | 27247228 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations. | 27247325 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | In recent years, it has been reported that the frequency of DNA-methylation regulatory gene mutations - mutations of the genes that regulate gene expression through DNA methylation - is high in acute myeloid leukemia. | 27247325 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Acute myeloid leukemia associated with a DNA-methylation regulatory gene mutation was more frequent in older patients (P<0.0001) and in patients with intermediate cytogenetic risk (P<0.0001) accompanied by a high white blood cell count (P=0.0032). | 27247325 |
| Liver carcinoma | Epigenetic Alterations | Comparison of genome-scale DNA methylation profiles in hepatocellular carcinoma by viral status. | 27248055 |
| Communicable Diseases, Hepatitis B, Hepatitis C, Hollings Cancer Center | Epigenetic Alterations | Our understanding of epigenetic regulation in HCC is still limited, especially the impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on aberrant DNA methylation. | 27248055 |
| Virus Diseases, Hollings Cancer Center | Epigenetic Alterations | Our findings of differential methylation by viral infection lend insights into the potential effects of viral infection on the epigenetic regulation and further the development and progression of HCC. | 27248055 |
| Primary malignant neoplasm | Epigenetic Alterations | microRNAs (miRNAs) play critical roles in cancer development and progression. | 27248318 |
| Neoplasms | Epigenetic Alterations | Tumors were considered to harbor active TAZ/YAP-driven gene transcription when they co-expressed TAZ, or YAP, and CTGF. | 27248471 |
| Carcinogenesis | Epigenetic Alterations | The majority of studies to date focused on genetic mutations and epigenetic changes that drive the CRC carcinogenesis process. | 27253631 |
| Carcinogenesis | Epigenetic Alterations | The restoration of ABCG2 function via modulating this new microRNA-methylation mechanism in precancerous cells may represent an attractive strategy to delay the carcinogenesis process. | 27253631 |
| Neoplasms | Epigenetic Alterations | One of these miRNA, miR-187, was significantly decreased in pre-treatment EAC tumors from patients having a poor response to neoadjuvant CRT, highlighting downregulation of miR-187 as a potential mechanism of treatment resistance in EAC. | 27254108 |
| Right arm | Epigenetic Alterations | MicroRNA-125b negatively regulates expression of TNF-a, which plays a crucial role in RA pathogenesis. | 27255643 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | It was proved that some miRNAs are significantly deregulated in rheumatoid arthritis (RA). | 27255643 |
| Loss of Chromosome 22q | Epigenetic Alterations | The recurrent loss of chromosome 22q appeared to contribute to this phenomenon by promoting the expression of epigenetic regulators, such as EZH2. | 27256159 |
| Glioma | Epigenetic Alterations | We conclude that deregulation of CPEB proteins may be a frequent phenomenon in gliomas and occurs on the level of transcription involving epigenetic mechanism as well as on the level of mRNA splicing, which generates isoforms with compromised biological properties. | 27256982 |
| DICER1 protein, human | Epigenetic Alterations | Dicer is an RNase III enzyme responsible for cleaving double-stranded RNAs into small interfering RNAs and microRNAs, which either target messenger RNA transcripts for degradation or inhibit translation. | 27260947 |
| Diabetes Mellitus, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | Serum microRNA-196 and microRNA-200 in pancreatic ductal adenocarcinoma of patients with diabetes mellitus. | 27267055 |
| Weight decreased | Epigenetic Alterations | MicroRNA-200 was significantly higher in PAC patients with significant body weight loss against those without weight loss. | 27267055 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Although increasing evidence demonstrated that deregulation of mircoRNA-503 (miRNA-503) contributes to tumorigenesis, little is known about the biological role and intrinsic regulatory mechanisms of miR-503 in prostate cancer (PCa). | 27267060 |
| Stomach Carcinoma | Epigenetic Alterations | Single nucleotide polymorphisms in miRNA-coding region may be involved in the development or progression of gastric cancer (GC). | 27267319 |
| Primary malignant neoplasm | Epigenetic Alterations | While lncRNAs (long noncoding RNAs) have been shown to have critical regulatory roles in cancer biology, the biological functions and prognostic values in nonmuscle invasive bladder cancer remain largely unknown. | 27267320 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We sought evidence for an association between the rs16906252C>T genotype and increased risk of developing a subtype of colorectal cancer featuring MGMT methylation, mediated by genotype-dependent epigenetic silencing within normal tissues. | 27267851 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We provide evidence that rs16906252C>T is associated with elevated risk for MGMT-methylated colorectal cancer, likely mediated by constitutive epigenetic repression of the T allele. | 27267851 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | However, potential mechanisms between lncRNAs and miRNAs in glioma remain largely unknown. | 27267902 |
| Neoplasms | Epigenetic Alterations | microRNAs (small non-coding RNAs) have proven to be effective biomarkers for the identification of tumors and tumor progression. | 27267924 |
| Chondrosarcoma, Neoplasms | Epigenetic Alterations | The data suggest these microRNAs would provide an analytical distinction between the chondrosarcoma and benign neoplasms that can be performed in formalin-fixed paraffin-embedded specimens. | 27267924 |
| Hereditary Breast and Ovarian Cancer Syndrome, Hereditary Diseases | Epigenetic Alterations | Of individuals with suspected hereditary breast and ovarian cancer (HBOC), approximately 30-70 % do not harbor mutations in either BRCA1 or BRCA2 gene, which suggests that these individuals have other genetic or epigenetic alterations that could lead to the onset of this hereditary disease. | 27271530 |
| ovarian neoplasm | Epigenetic Alterations | Further studies are needed to clarify whether other mutations/epigenetic alterations are involved in the pathogenesis of BRCA1 or BRCA2 mutation-negative inherited disease with breast or ovarian cancer. | 27271530 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer. | 27271609 |
| Clinical Coordinator | Epigenetic Alterations | Inhibition of DNA methylation recovered FOXE1 expression in CRC cells. | 27271927 |
| Hepatitis C, Liver carcinoma | Epigenetic Alterations | Serum microRNA panels as potential biomarkers for early detection of hepatocellular carcinoma on top of HCV infection. | 27271989 |
| Liquid Chromatography, Hollings Cancer Center | Epigenetic Alterations | Using miRNA panel of miR-122, miR-885-5p, and miR-29b with alpha fetoprotein (AFP) provided high diagnostic accuracy (AUC = 1) for early detection of HCC in normal population while using miRNA panel of miR-122, miR-885-5p, miR-221, and miR-22 with AFP provided high diagnostic accuracy (AUC = 0.982) for early detection of HCC in LC patients. | 27271989 |
| Carcinogenic Chlorinated Hydrocarbon, Hollings Cancer Center | Epigenetic Alterations | However, using miRNA panel of miR-22 and miR-199a-3p with AFP provided high diagnostic accuracy (AUC = 0.988) for early detection of HCC in CHC patients. | 27271989 |
| Hollings Cancer Center | Epigenetic Alterations | We identified serum miRNA panels that could have a considerable clinical use in early detection of HCC in both normal population and high-risk patients. | 27271989 |
| Communicable Diseases, Hepatitis C, Hollings Cancer Center | Epigenetic Alterations | We aimed at identifying serum microRNAs (miRNAs) as potential biomarkers for early detection of HCC on top hepatitis C virus (HCV) infection. | 27271989 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort. | 27274774 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-320 was downregulated in non-small cell lung cancer and inhibited cell proliferation, migration and invasion by targeting fatty acid synthase. | 27277534 |
| Neoplasms | Epigenetic Alterations | Micro ribonucleic acid (RNA)-93 (miR-93) is a novel oncogenic miRNA dysregulated in many types of tumors. | 27279231 |
| Periodontitis | Epigenetic Alterations | DNA methylation of the cytokine genes may play a role in the pathogenesis of periodontitis. | 27280944 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Circulating microRNAs in patients with ST-elevation myocardial infarction. | 27282672 |
| NSD1 protein, human, CHEK2 gene | Epigenetic Alterations | New somatic alterations were identified in oncogenes (MDM2, FLI1), transcription factors and repressors (MITF, FLI1, ZNF331), epigenetic enzymes (KMT2A, NSD1, NCOA1, NCOA2), and protein kinases (JAK3, CHEK2, ALK). | 27283500 |
| cervical cancer | Epigenetic Alterations | MicroRNA-218 inhibits EMT, migration and invasion by targeting SFMBT1 and DCUN1D1 in cervical cancer. | 27285984 |
| cervical cancer, Primary malignant neoplasm | Epigenetic Alterations | Here, we reported that miR-218 (microRNA-218) was downregulated in cervical cancer tissues, especially in metastatic cancer tissues. | 27285984 |
| Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4. | 27286257 |
| Clinical Coordinator | Epigenetic Alterations | Five miRNA target prediction programs were applied to identify potential miRNA(s) that target(s) Smad4 in CRC. | 27286257 |
| Clinical Coordinator, Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | miR-20a-5p, as an onco-miRNA, promoted the invasion and metastasis ability by suppressing Smad4 expression in CRC cells, and high miR-20a-5p predicted poor prognosis for CRC patients, providing a novel and promising therapeutic target in human colorectal cancer. | 27286257 |
| Primary malignant neoplasm | Epigenetic Alterations | Mechanistically, LPS stimulation increased expression levels of microRNA-21 (miR-21) in primary human lung cancer cells. | 27286259 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | TLR4/ROS/miRNA-21 pathway underlies lipopolysaccharide instructed primary tumor outgrowth in lung cancer patients. | 27286259 |
| Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | Downregulation of long non-coding RNA ANRIL suppresses lymphangiogenesis and lymphatic metastasis in colorectal cancer. | 27286457 |
| ABCB1 wt Allele | Epigenetic Alterations | However, frequent simultaneous methylation of the studied genes in more than 50 % of NSCLCs suggests the possibility of consider them as a panel of epigenetic markers. | 27287342 |
| Recombinant Interferon-gamma | Epigenetic Alterations | Increasing levels of microRNA (miRNA)-21 can lead to IFN-g deficiency, thereby suppressing immune function. | 27288814 |
| Cerebrovascular accident | Epigenetic Alterations | The stroke with SAI group had significantly higher miRNA-21 expression and lower IFN-g levels than the stroke without SAI group (p<0.05). | 27288814 |
| Acute Cerebrovascular Accidents | Epigenetic Alterations | Plasma up-regulated miRNA-21 and decreased IFN-g in acute stroke can be considered new biological predictors for SAI and thus, new therapeutic targets. | 27288814 |
| Heart failure, Inflammation | Epigenetic Alterations | A set of six microRNAs implicated in inflammation (miR-155 and miR-146b), heart failure (miR-21 and miR-133a), and endothelial cell (miR-126) and skeletal muscle function (miR-206) was pre-defined. | 27292200 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | We found microRNA-133b (miR-133b) was downregulated in urothelial carcinoma of the bladder (UCB) tissues, and it could inhibit the proliferation and induce apoptosis in UCB cells. | 27292588 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) represent an emerging layer of cancer biology and have been implicated in the development and progression of cancers. | 27292966 |
| Breast Carcinoma | Epigenetic Alterations | Decreased Expression of Bioinformatically Predicted piwil2-targetting microRNAs, miR-1267 and miR-2276 in Breast Cancer. | 27293058 |
| Breast Carcinoma | Epigenetic Alterations | Considering the vital role of microRNAs (miRNAs) in regulating the expression of most human genes, we hypothesized a concomitant downregulation of the bioinformatically-predicted piwil2-targetting microRNAs in breast cancer. | 27293058 |
| Pulmonary Complication, Cessation of life | Epigenetic Alterations | High miRNA-21 was also associated with an increased risk of extrapulmonary complications (OR, 3.62; 95% CI, 2.26-5.81; and P < 0.001), prolonged ICU stay (OR, 6.54; 95% CI, 2.26-18.19; and P < 0.001), increased death within 30 days (OR, 6.17; 95% CI, 2.11-18.08; and P < 0.001), and death within 1 year (OR, 7.30; 95% CI, 2.76-19.28; and P < 0.001). | 27293316 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Clinical stage and risk of recurrence and mortality: interaction of DNA methylation factors in patients with colorectal cancer. | 27296458 |
| Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation plays a crucial role in cancer development; however, prospective evidence of an interaction between molecular biomarkers and cancer staging for predicting the prognosis of colorectal cancer (CRC) is still limited. | 27296458 |
| Clinical Coordinator, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | We examined DNA methylation in tumors and adjacent normal tissues from patients who underwent CRC surgical resection, and evaluated the interaction between cancer staging (advanced vs local) and DNA methylation to predict the prognosis of CRC. | 27296458 |
| Clinical Coordinator | Epigenetic Alterations | DNA methylation status would significantly increase the recurrence risk of CRC with a significant impact on joint effect between DNA methylation and clinical stage, particularly in matched normal tissues. | 27296458 |
| Neoplasms | Epigenetic Alterations | This study showed that circRNAs are differentially expressed in cSCC and play an important role in tumor formation by interfering with cSCC relevant miRNAs through miRNA sequence complementary MREs participating in epigenetic control. | 27298156 |
| Hollings Cancer Center | Epigenetic Alterations | miRNA array screening showed that miR-106b and its cluster, miR-93 and miR-25 were up-regulated in HCC patients (P < 0.01). | 27298561 |
| Malignant tumor of colon | Epigenetic Alterations | To detect the expression of the long noncoding RNA HOTAIR in colon cancer and analyze its relationship with clinicopathological parameters of colon cancer. | 27298568 |
| Glaucoma, CTCAE | Epigenetic Alterations | Increased Global DNA Methylation and Decreased TGFb1 Promoter Methylation in Glaucomatous Lamina Cribrosa Cells. | 27300643 |
| Glaucoma, CTCAE, Fibrosis Assessment | Epigenetic Alterations | DNA methylation is well established in regulating fibrosis and may be a therapeutic target for glaucoma. | 27300643 |
| Liver carcinoma | Epigenetic Alterations | The long noncoding RNA HOTAIR activates autophagy by upregulating ATG3 and ATG7 in hepatocellular carcinoma. | 27301338 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | The long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been reported to be an oncogene that influences tumor cell development and that correlates with prognosis in hepatocellular carcinoma (HCC). | 27301338 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming. | 27302925 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Taken together, our findings reveal the occurrence of epigenetic reprogramming taking place within CLL patient CD8+ T cells and highlight the potential mechanism of how immunosuppression is accomplished in CLL. | 27302925 |
| Endometrial Carcinoma | Epigenetic Alterations | DNA methylation and DNA methyltransferase (DNMT1) activity pattern in endometrial carcinoma. | 27306462 |
| Atypical Reparative Cell | Epigenetic Alterations | The study supports the notion that the epigenetic modification of macromolecules in LECs might contribute to ARC pathogenesis. | 27306760 |
| Neoplasms | Epigenetic Alterations | Recent studies have revealed many different long noncoding RNAs (lncRNA), however, the investigation for their function and clinical value as tumour biomarkers has scarcely begun. | 27307307 |
| Coronary Artery Disease | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in the pathogenesis of coronary artery disease (CAD). | 27313333 |
| Breast Cancer Cell | Epigenetic Alterations | Antisense noncoding RNA in the INK4 locus (ANRIL) has been reported to be upregulated in various types of human cancer, and is also highly expressed in normal human tissue. | 27314206 |
| Heart failure | Epigenetic Alterations | Long noncoding RNA dysregulation in ischemic heart failure. | 27317124 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNA-23a-3p promotes the development of osteoarthritis by directly targeting SMAD3 in chondrocytes. | 27318087 |
| Septicemia, Systemic Inflammatory Response Syndrome | Epigenetic Alterations | Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS). | 27320175 |
| Inflammation | Epigenetic Alterations | MicroRNAs regulate cellular processes including inflammation and may be detected in blood. | 27320175 |
| Systemic Inflammatory Response Syndrome | Epigenetic Alterations | Detectable blood miRNAs (n = 116) were generally up-regulated in SIRS compared to no-SIRS patients. | 27320175 |
| Septicemia, Systemic Inflammatory Response Syndrome | Epigenetic Alterations | Six CIR-miRNAs (miR-30d-5p, miR-30a-5p, miR-192-5p, miR-26a-5p, miR-23a-5p, miR-191-5p) provided good-to-excellent discrimination of severe sepsis from severe SIRS (0.742-0.917 AUC of ROC curves). | 27320175 |
| Inflammation | Epigenetic Alterations | CIR-miRNAs may be regulators of inflammation and warrant thorough evaluation as diagnostic and therapeutic targets. | 27320175 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer. | 27322075 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis. | 27322206 |
| Pancreatic carcinoma | Epigenetic Alterations | These results connect miR-1291 to the FOXA2-AGR2 regulatory pathway in the suppression of pancreatic cancer cell proliferation and tumorigenesis, providing new insight into the development of miRNA-based therapy to combat pancreatic cancer. | 27322206 |
| Carcinoma of lung, Malignant neoplasm of lung | Epigenetic Alterations | Here, we screened for abnormal long noncoding RNAs (lncRNAs) in lung cancers from patients living in Xuanwei city which has the highest lung cancer incidence in China due to smoky coal combustion-generated air pollution. | 27322209 |
| Hollings Cancer Center | Epigenetic Alterations | The let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC. | 27323017 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | MicroRNAs (miRNAs) are key regulators of gene expression and play an important role in the development and progression of various diseases including esophageal squamous cell carcinoma (ESCC). | 27323028 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | We also observed widespread ncRNA correlation to concurrent TP53 and chromosome 3p loss, a compelling predictor of poor prognosis in HNSCCs. | 27323410 |
| Neoplasms | Epigenetic Alterations | MicroRNAs are involved in tumor initiation and progression by regulating oncogenes and tumor suppressor genes. | 27323412 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Downregulation of the long noncoding RNA TUG1 inhibits the proliferation, migration, invasion and promotes apoptosis of renal cell carcinoma. | 27323757 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Exploration of the interplay between specific miRNAs and genes, which are critically involved in the functioning of the biological clock, provides a better understanding of the importance of the miRNA-clock genes axis and its derangement in colorectal cancer. | 27323779 |
| Metastasis | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) play critical roles in diverse biological processes such as tumorigenesis and metastasis. | 27329359 |
| Carcinoma, Transitional Cell, Neoplasms | Epigenetic Alterations | Human urothelial carcinoma associated 1 (UCA1) is a long noncoding RNA that is putatively oncogenic in solid tumors. | 27329842 |
| Sjogrens Syndrome | Epigenetic Alterations | Epigenetic Signatures of Salivary Gland Inflammation in Sjogrens Syndrome. | 27332624 |
| cervical cancer | Epigenetic Alterations | Genetic variants within microRNA-binding site of RAD51B are associated with risk of cervical cancer in Chinese women. | 27334422 |
| Malignant Neoplasms, cervical cancer | Epigenetic Alterations | In summary, our study suggested that miRNA-binding site genetic variants of RAD51B may modify the susceptibility to cervical cancer, which is important to identify individuals with differential risk for this malignancy and to improve the effectiveness of preventive intervention. | 27334422 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are frequently dysregulated in tumors, play a crucial role during carcinogenesis and therefore might be promising new biomarkers. | 27336447 |
| Breast Carcinoma | Epigenetic Alterations | Transcriptome sequencing uncovers a three-long noncoding RNA signature in predicting breast cancer survival. | 27338266 |
| Breast Carcinoma | Epigenetic Alterations | In addition, lncRNA, miRNA, and mRNA interaction network indicated lncRNAs may intervene in breast cancer pathogenesis by binding to miR-190b, acting as competing endogenous RNAs. | 27338266 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Aberrant methylation-mediated downregulation of long noncoding RNA LOC100130476 correlates with malignant progression of esophageal squamous cell carcinoma. | 27338851 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | Dysregulated long non-coding RNAs (lncRNAs) are involved in many complicated human diseases including cancer. | 27338851 |
| Primary Myelofibrosis | Epigenetic Alterations | A data-driven network model of primary myelofibrosis: transcriptional and post-transcriptional alterations in CD34+ cells. | 27341078 |
| Metastasis, Glioblastoma Multiforme Pathway | Epigenetic Alterations | TP53INP1 3-UTR functions as a ceRNA in repressing the metastasis of glioma cells by regulating miRNA activity. | 27341836 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Moreover, TP53INP1 3-UTR inhibited glioma cell proliferation, invasion and proliferation; Furthermore, the 3-UTRs of TP53INP1 and E-cadherin harboured seven identical miRNAs binding sites, and TP53INP1 3-UTR could increase the expression of E-cadherin and decrease the expression of vimentin thus repressing the epithelial-mesenchymal transition (EMT). | 27341836 |
| cervical cancer | Epigenetic Alterations | miRNA-145 and 9 may be as potential prognostic marker in patients suffering from cervical cancer. | 27345415 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) may act as carcinogen or tumor suppressor genes by targeting various biological molecules. | 27345415 |
| cervical cancer | Epigenetic Alterations | miRNAs expression was detected using quantitative real-time polymerase chain reaction in cervical cancer specimens and adjacent normal tissues. | 27345415 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Plasma miRNA-506 as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma. | 27345473 |
| Neoplasms | Epigenetic Alterations | miRNA-506 is abnormally expressed in multiple tumors, indicating that it might be oncogenic or tumor-suppressive. | 27345473 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | However, little is known about the association between miRNA-506 expression and esophageal squamous cell carcinoma (ESCC). | 27345473 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | ROC curves were produced for ESCC diagnosis by plasma miRNA-506 and the area under curve was calculated to explore its diagnostic value. | 27345473 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | RESULTS Average miRNA-506 expression levels were remarkably higher in the plasma of ESCC patients than in healthy volunteers (P<0.001). | 27345473 |
| Tetranitromethane, Neoplasms | Epigenetic Alterations | The expression of miRNA-506 in the plasma was closely associated with lymph node status (P=0.004), TNM stage (P=0.031), and tumor length (P<0.001). | 27345473 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | According to ROC curves, the area under the curve for plasma miRNA-506 was 0.835, indicating statistical significance for ESCC diagnosis by plasma miRNA-506 (P<0.001). | 27345473 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | Cox regression analysis demonstrated that T stage, N stage, tumor length, and miRNA-506 expression levels were significantly correlated with prognosis in ESCC patients. | 27345473 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | CONCLUSIONS miRNA-506 can serve as an important molecular marker for diagnosis and prognostic prediction of ESCC. | 27345473 |
| Metastasis, Neoplasms | Epigenetic Alterations | BACKGROUND MicroRNAs (miRNAs) are responsible for regulating proliferation, differentiation, apoptosis, invasion, and metastasis in tumor cells. | 27345473 |
| Acute Coronary Syndrome | Epigenetic Alterations | Serum miRNA-499 and miRNA-210: A potential role in early diagnosis of acute coronary syndrome. | 27346801 |
| CO-methylating acetyl-CoA synthase activity | Epigenetic Alterations | Both miRNAs might be potentially novel biomarkers for accelerating the diagnosis of ACS patients in emergency unit. | 27346801 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | We assessed plasma microRNA-21 levels in patients with colorectal cancer (CRC) at different stages and in patients with benign polyps. | 27349026 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent evidence suggests that microRNAs play an important role in cancer diagnostics. | 27349026 |
| Chronic pain | Epigenetic Alterations | MicroRNAs (miRNA) can regulate both immune and neuronal processes and may function as master switches in chronic pain development and maintenance. | 27349406 |
| Feel Pain | Epigenetic Alterations | Subsequently, miR-132-3p expression was pharmacologically modulated with miRNA antagonists or mimetics, and evoked pain and pain aversion were assessed. | 27349406 |
| diabetic | Epigenetic Alterations | Here, we show that miR-93 is a critical metabolic/epigenetic switch in the diabetic milieu linking the metabolic state to chromatin remodelling. | 27350436 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway. | 27351135 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, the long non-coding RNA (lncRNA) NEAT1 has been identified as an oncogenic gene in multiple cancer types and elevated expression of NEAT1 was tightly linked to tumorigenesis and cancer progression. | 27351135 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Taken together, these observations imply that the NEAT1 modulated the expression of E2F3 gene by acting as a ceRNA, which may build up the missing link between the regulatory miRNA network and NSCLC progression. | 27351135 |
| Primary malignant neoplasm | Epigenetic Alterations | Prospective changes in global DNA methylation and cancer incidence and mortality. | 27351216 |
| Peripheral Vascular Diseases | Epigenetic Alterations | Among these miRNAs, we identified miR-21 as a candidate fibrotic miRNA with an important role in the pathogenesis of PVD. | 27351379 |
| Retinal fibrosis, Vitreous humor, Peripheral Vascular Diseases | Epigenetic Alterations | Together, our studies have identified miR-21 as a potential disease-modifying miRNA in the vitreous humor that is involved in the development of retinal fibrosis and may be a novel marker of PVD. | 27351379 |
| Vitreoretinal Area, Vitreous humor | Epigenetic Alterations | Aberrant expression of miRNAs in the vitreous humor of vitreoretinal diseased eyes has been reported. | 27351379 |
| Fibrosis Assessment, Peripheral Vascular Diseases | Epigenetic Alterations | The expression of a specific subset of miRNAs, previously reported to be associated with the development of angiogenesis and fibrosis, was significantly altered in the vitreous of PVD patients. | 27351379 |
| Malignant tumor of colon | Epigenetic Alterations | Distinct Transcriptional Changes and Epithelial-Stromal Interactions Are Altered in Early-Stage Colon Cancer Development. | 27353028 |
| Neuroendocrine Tumors | Epigenetic Alterations | MicroRNAs associated with small bowel neuroendocrine tumours and their metastases. | 27353039 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-140 Inhibits Cell Proliferation in Gastric Cancer Cell Line HGC-27 by Suppressing SOX4. | 27353653 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNAs are important regulators of gene expression, influencing the progression of gastric cancer. | 27353653 |
| Metabolic Syndrome X | Epigenetic Alterations | Circulating MicroRNA-21 is Downregulated in Patients with Metabolic Syndrome. | 27353714 |
| Primary malignant neoplasm | Epigenetic Alterations | The microRNA-21 (miR-21) is known to play a major role in cancer progression; however, its function in the cardiovascular system appears to be even more complex and conflicting. | 27353714 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. | 27354594 |
| Clinical Coordinator | Epigenetic Alterations | DOK3 rs2279398G>A may affect the expression of DOK3 by altering the miRNA binding efficiency at the miRNA-binding sites of the 3-UTR in DOK3, thereby impacting CRC tumorigenesis. | 27354594 |
| Autoimmune Diseases | Epigenetic Alterations | Additionally, disorders of epigenetic processes, in particular non-random X chromosome inactivation (XCI), have been reported in many female-predominant autoimmune diseases. | 27355582 |
| Hippocampal atrophy, "Alzheimers Disease", Amnesia, CTCAE, Impaired cognition | Epigenetic Alterations | DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy in Alzheimers disease and amnesic mild cognitive impairment patients. | 27356276 |
| Impaired cognition, Admitting diagnosis, Amnesia, CTCAE | Epigenetic Alterations | We have already reported that DNA methylation levels in the NCAPH2/LMF2 promoter region can be a useful biomarker for the diagnosis of AD and amnesic mild cognitive impairment (aMCI). | 27356276 |
| Hippocampal atrophy | Epigenetic Alterations | Our results suggest that DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy through apoptosis. | 27356276 |
| Uveal melanoma | Epigenetic Alterations | Oncogenic role of microRNA-20a in human uveal melanoma. | 27356499 |
| MIR20A gene, Primary malignant neoplasm | Epigenetic Alterations | As a member of the microRNA (miR)-17-92 cluster, miR-20a has been indicated to be involved in the regulation of the proliferation and invasion of various cancer cells. | 27356499 |
| MIR20A gene | Epigenetic Alterations | These data provided convincing evidence that miR-20a may function as an oncogenic miRNA, and may be involved in promoting cell growth and motility in the molecular etiology of UM, suggesting its potential as a candidate therapeutic target for the treatment of patients with UM. | 27356499 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA-335 inhibits bladder cancer cell growth and migration by targeting mitogen-activated protein kinase 1. | 27356628 |
| CO-methylating acetyl-CoA synthase activity, Acute Coronary Syndrome | Epigenetic Alterations | Recently, we identified eight microRNAs (miRNAs), which facilitated acute coronary syndrome (ACS) diagnosis. | 27357355 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The dysregulation of microRNAs (miRNAs) has been demonstrated to contribute to drug resistance of cancer cells, and sustained nuclear factor (NF)kB activation is also pivotal in tumor resistance to chemotherapy. | 27357419 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Here, we describe for the first time a comprehensive characterization of miRNA expression in human fetal lung tissue, with subsequent identification of 37 miRNAs in non-small cell lung cancer (NSCLC) that recapitulate their fetal expression patterns. | 27357447 |
| Aggressive behavior, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma. | 27357447 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Interrogation of NFIB copy number, methylation, and mutation status revealed that DNA level disruption of this gene is rare, and further supports the notion that oncofetal miRNAs are likely the primary mechanism responsible for NFIB underexpression in NSCLC. | 27357447 |
| Carcinogenesis | Epigenetic Alterations | Dysregulation of microRNAs (miRNAs) have been demonstrated to contribute to carcinogenesis. | 27358073 |
| Prostate Cancer Pathway | Epigenetic Alterations | Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer. | 27358489 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Epigenome-wide DNA methylation profiling was performed in surgically resected primary tumor tissues from a population-based (n = 430) and a replication (n = 80) cohort of prostate cancer patients followed prospectively for at least 5 years. | 27358489 |
| Prostatic Neoplasms | Epigenetic Alterations | We hypothesized that epigenetic alterations could distinguish prostate tumors with life-threatening potential. | 27358489 |
| Prostate Cancer Pathway, Aggressive behavior | Epigenetic Alterations | These novel epigenetic biomarkers warrant further investigation as they may improve prognostic classification of patients with clinically localized prostate cancer and provide new insights on tumor aggressiveness. | 27358489 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Functional investigations showed that MEF2D promoted cancer cell invasion and EMT and that it was essential for certain microenvironment signals to induce EMT and metastasis in vivo Mechanistically, MEF2D directly regulated transcription of the EMT driver gene ZEB1 and facilitated histone acetylation at the ZEB1 promoter. | 27364559 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Genome-wide microRNA Expression Profiling in Primary Tumors and Matched Liver Metastasis of Patients with Colorectal Cancer. | 27365381 |
| Primary Neoplasm, Secondary malignant neoplasm of liver | Epigenetic Alterations | Firstly, expression profiling of 752 miRNAs in 20 primary tumors and their corresponding liver metastases was performed. | 27365381 |
| Secondary malignant neoplasm of liver, Primary Neoplasm | Epigenetic Alterations | In total, 33 miRNAs were found to be significantly deregulated in liver metastases compared to their primary tumors. | 27365381 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | Fifteen miRNAs were chosen for subsequent validation, which confirmed significantly reduced expression of miR-143, miR 10b, and miR-28-5p, and increased expression of miR 122, miR-122*, and miR 885-5p in the tissue of liver metastases. | 27365381 |
| Clinical Coordinator | Epigenetic Alterations | These results indicate that miRNAs could serve as new therapeutic targets in patients with metastatic CRC. | 27365381 |
| NCI CTEP SDC Oligodendroglial Tumors Sub-Category Terminology | Epigenetic Alterations | The influence of DNA methylation in oligodendroglial tumors is not fully understood. | 27367901 |
| Neurotoxicity Syndromes, Antilymphocyte Serum | Epigenetic Alterations | Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients. | 27368295 |
| Neurotoxicity Syndromes, Antilymphocyte Serum | Epigenetic Alterations | We hypothesize that higher macrophage abundance and increased neurotoxic cytokines have a fundamental role in the phenotype and treatment of certain individuals with ALS.-Lam, L., Chin, L., Halder, R. C., Sagong, B., Famenini, S., Sayre, J., Montoya, D., Rubbi L., Pellegrini, M., Fiala, M. Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients. | 27368295 |
| Cessation of life, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Expression of programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) across glioma grades is undocumented, and their interactions with commonly expressed genetic and epigenetic alterations are undefined but nonetheless highly relevant to combinatorial treatments. | 27370400 |
| Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression. | 27371108 |
| Neoplasms | Epigenetic Alterations | MicroRNA-506 (miR-506) has been reported to function in several tumors as a tumor suppressor gene or oncogene. | 27371108 |
| Neoplasms | Epigenetic Alterations | Our results suggest that miR-506 either plays a role as an oncogene in the tumorigenesis and a tumor suppressor in the progression or serves as a house-keeping, tumor-suppressing miRNA, whose expression can be activated by oncogenic signals in early development to hinder the progression of PDAC. | 27371108 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MiRNA-200a expression is inverse correlation with hepatocyte growth factor expression in stromal fibroblasts and its high expression predicts a good prognosis in patients with non-small cell lung cancer. | 27374174 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | High miRNA-200a and low HGF expression in stromal fibroblasts may predict a good prognosis in patients with NSCLC. | 27374174 |
| Esophageal carcinoma | Epigenetic Alterations | However, the epigenetic changes and mechanisms of NKD2 in human esophageal cancer remain unclear. | 27374455 |
| Malignant Neoplasms, Vascular Diseases | Epigenetic Alterations | Polymorphisms in microRNA (miR) genes are thought to be associated with various cancers and vascular diseases. | 27379568 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | MicroRNA-205-5p is upregulated in myelodysplastic syndromes and induces cell proliferation via PTEN suppression. | 27379838 |
| Pancreatic carcinoma, Autoimmune Pancreatitis | Epigenetic Alterations | Specific MAPK-Associated MicroRNAs in Serum Differentiate Pancreatic Cancer from Autoimmune Pancreatitis. | 27380024 |
| Pancreas | Epigenetic Alterations | Recently it has been reported that these miRNAs could be used as biomarkers in serum samples for accurate diagnosis of pancreatic lesions. | 27380024 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm, Acute intermittent porphyria | Epigenetic Alterations | Patients with PDAC or IPMN showed significantly higher amounts of serum MAPK-associated miRNAs than those with AIP (p<0.009 for miR-7, p<0.002 for miR-34a, p<0.001 for miR-181d, p<0.002 for miR-193b). | 27380024 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm, Acute intermittent porphyria | Epigenetic Alterations | Serum MAPK-associated miRNAs could be novel noninvasive biomarkers for differentiation between PDAC or IPMN and AIP. | 27380024 |
| Breast Carcinoma | Epigenetic Alterations | Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry. | 27380242 |
| Breast Carcinoma | Epigenetic Alterations | While germline genetic variations may disrupt some of these interactions between miRNAs and their targets, studies assessing the relationship between genetic variations in the miRNA network and breast cancer risk are still limited, particularly among women of African ancestry. | 27380242 |
| Breast Carcinoma | Epigenetic Alterations | For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have significant associations in both discovery and validation phases. | 27380242 |
| Breast Carcinoma | Epigenetic Alterations | Several variants in miRNA and miRNA biogenesis pathway genes were associated with breast cancer risk. | 27380242 |
| Stomach Carcinoma | Epigenetic Alterations | Serum microRNA expression profile as a diagnostic panel for gastric cancer. | 27380811 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Previously, we identified six miRNAs that are differentially expressed in colorectal cancer compared with healthy controls. | 27380811 |
| Stomach Carcinoma | Epigenetic Alterations | The signature of these five miRNAs is a novel and noninvasive biomarker for gastric cancer, and could facilitate and simplify its diagnosis. | 27380811 |
| Pulmonary Hypertension | Epigenetic Alterations | Upregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via Targeting CCNL2. | 27381447 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | During the last decades it has been established that breast cancer arises through the accumulation of genetic and epigenetic alterations in different cancer related genes. | 27383829 |
| bone destruction | Epigenetic Alterations | The expression of these two miRNAs may indicate severity of bone destruction. | 27384730 |
| Adenocarcinoma of prostate | Epigenetic Alterations | Adenocarcinomas of the prostate arise as multifocal heterogeneous lesions as the likely result of genetic and epigenetic alterations and deranged cell-cell communication. | 27384993 |
| Intervertebral Disc Degeneration, Primary malignant neoplasm | Epigenetic Alterations | Accumulating evidence indicates that miRNAs, a class of small non-coding RNAs, are implicated in the pathogenesis of various diseases such as cancer and intervertebral disc degeneration. | 27385596 |
| Intervertebral Disc Degeneration | Epigenetic Alterations | microRNA-34a inhibition may be a novel molecular target for intervertebral disc degeneration treatment through the prevention of nucleus pulposus extracellular matrix degradation. | 27385596 |
| Von Hippel-Lindau Syndrome, Neoplasms | Epigenetic Alterations | Despite the identification of germline and/or epigenetic mutations of Von Hippel Lindau (VHL) gene as an important pathogenic mechanism of HB, little is known about the molecular signaling involved in this highly vascularized tumor. | 27388534 |
| Cerebral Ischemia | Epigenetic Alterations | Lentivirus-Mediated Overexpression of MicroRNA-210 Improves Long-Term Outcomes after Focal Cerebral Ischemia in Mice. | 27390218 |
| Brain Injuries | Epigenetic Alterations | MicroRNAs play an important role in the pathogenesis of ischemic brain injury and in the repair process during postischemic condition. | 27390218 |
| Cerebrovascular accident | Epigenetic Alterations | We found that 24 MicroRNAs were differently expressed in stroke patients compared to the control (P < 0.05). | 27390218 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NF-kB and sustains NF-kB activation by decreasing Cylindromatosis expression. | 27391066 |
| Acute lymphocytic leukemia | Epigenetic Alterations | We further observed that CK2 inhibitor induces increased H3K9me3 histone modifications in the CRLF2 promoter in ALL cell lines and primary cells. | 27391346 |
| SERPINB3 wt Allele | Epigenetic Alterations | In addition, we validated seven microRNAs whose expression was shown to be higher in OLD tissue in comparison with the control and OSCC tissues. | 27391377 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway | Epigenetic Alterations | Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer. | 27391432 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Our findings suggest that attenuated expression of miR-185 and miR-186 may be responsible for collagen V overexpression during idiopathic pulmonary fibrosis, and these miRNAs may serve as pathogenesis-related biomarkers and treatment targets. | 27392970 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers. | 27393180 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | We have generated mRNA, miRNA, and DNA copy-number profiles from a total of 59 in situ lesions and 85 invasive tumors in order to comprehensively identify those genes, signaling pathways, processes, and cell types that are involved in breast cancer progression. | 27396337 |
| Breast Carcinoma, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Loss of microRNA-145 expression is involved in the development and prognosis of breast cancer complicated by type 2 diabetes mellitus. | 27396353 |
| hearing impairment | Epigenetic Alterations | Thus, other modification factors, such as environmental factor, aminoglycosides or epigenetic modification may have contributed to the high penetrance of hearing loss in this family. | 27397648 |
| Malignant Neoplasms, Metastasis, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) in tumors participate in multiple processes of malignancy development, including cell differentiation, proliferation, invasion, and metastasis. | 27399918 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The effect of celecoxib on DNA methylation of CDH13, TFPI2, and FSTL1 in squamous cell carcinoma of the esophagus in vivo. | 27400374 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | In ESCC, in-vivo treatment with celecoxib is associated with a reduction in DNA methylation and increase in messenger RNA expression of tumor-suppressor genes, and increases in apoptosis. | 27400374 |
| Chordoma, Primary malignant neoplasm | Epigenetic Alterations | These 294 differentially expressed genes and non-coding RNA transcripts provide here a set to specifically define skull base chordomas and to identify novel and potentially important targets for diagnosis, prognosis, and therapy of this cancer. | 27401718 |
| cervical cancer, Cervical Intraepithelial Neoplasia | Epigenetic Alterations | To conduct a comprehensive mapping of the genomic DNA methylation in CDKN2A, which codes for the p16(INK4A) and p14(ARF) proteins, and 14 of the most promising DNA methylation marker candidates previously reported to be associated with progression of low-grade cervical intraepithelial neoplasia (CIN1) to cervical cancer. | 27401842 |
| cervical cancer | Epigenetic Alterations | We analyzed DNA methylation in 68 HIV-seropositive and negative women with incident CIN1, CIN2, CIN3 and invasive cervical cancer, assaying 120 CpG dinucleotide sites spanning APC, CDH1, CDH13, CDKN2A, CDKN2B, DAPK1, FHIT, GSTP1, HIC1, MGMT, MLH1, RARB, RASSF1, TERT and TIMP3 using the Illumina Infinium array. | 27401842 |
| Primary malignant neoplasm | Epigenetic Alterations | In our discovery sample set, we identified dose dependent differences in DNA methylation with grade of disease in CDKN2A, APC, MGMT, MLH1 and HIC1, whereas single CpG locus differences between CIN2/3 and cancer groups were seen for CDH13, DAPK1 and TERT. | 27401842 |
| Cervix Diseases, malignant disease | Epigenetic Alterations | Our data suggests a novel link between early cervical disease progression and DNA methylation in a region downstream of the CDKN2A transcription start site that may lead to increased p16(INK4A)/p14(ARF) expression prior to development of malignant disease. | 27401842 |
| Cervical Intraepithelial Neoplasia | Epigenetic Alterations | Novel epigenetic changes in CDKN2A are associated with progression of cervical intraepithelial neoplasia. | 27401842 |
| Carcinoma, Ovarian Epithelial | Epigenetic Alterations | Development and validation of a microRNA-based signature (MiROvaR) to predict early relapse or progression of epithelial ovarian cancer: a cohort study. | 27402147 |
| Carcinoma, Ovarian Epithelial | Epigenetic Alterations | We aimed to develop a microRNA (miRNA)-based molecular classifier that can predict risk of progression or relapse in patients with epithelial ovarian cancer. | 27402147 |
| ovarian neoplasm | Epigenetic Alterations | We identified 35 miRNAs that predicted risk of progression or relapse and used them to create a prognostic model, the 35-miRNA-based predictor of Risk of Ovarian Cancer Relapse or progression (MiROvaR). | 27402147 |
| Malignant neoplasm of larynx, Liquid Chromatography | Epigenetic Alterations | MicroRNAs (miRNAs) play critical roles in the progression of laryngeal cancer (LC). | 27403438 |
| Initiation, Primary malignant neoplasm | Epigenetic Alterations | The small noncoding RNAs (miRNAs) considered as master regulator of gene expression play a key role in cancer initiation, progression and drug resistance and have emerged as attractive molecular biomarkers for diagnosis, prognosis and treatment targets in cancer. | 27404381 |
| Breast Carcinoma | Epigenetic Alterations | Identification of Specific miRNA Signature in Paired Sera and Tissue Samples of Indian Women with Triple Negative Breast Cancer. | 27404381 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | We report for the first time an extremely high prevalence (73.9%) of TNBC in premenopausal women below 35 years of age and a significant altered expression of a panel of three specific oncogenic miRNAs- miR-21, miR-221, miR-210, and three tumor suppressor miRNAs- miR-195, miR-145 and Let-7a in both tissues and corresponding sera of TNBC patients when compared with triple positive breast cancer (TPBC) patients. | 27404381 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease. | 27409149 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | We performed miRNA and mRNA profiling using high throughput stem-loop reverse-transcriptase quantitative polymerase chain reaction and mRNA microarray, respectively, on lung tissue of 30 patients (screening cohort) encompassing 8 never-smokers, 10 smokers without airflow limitation, and 12 smokers with COPD. | 27409149 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Differential expression of miRNA-218-5p (miR-218-5p) was validated by reverse-transcriptase quantitative polymerase chain reaction in an independent cohort of 71 patients, an in vivo murine model of COPD, and primary human bronchial epithelial cells. | 27409149 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | To identify dysregulated miRNAs in lung tissue of patients with chronic obstructive pulmonary disease (COPD). | 27409149 |
| Breast Carcinoma | Epigenetic Alterations | Identification of a circulating microRNA signature to distinguish recurrence in breast cancer patients. | 27409424 |
| Breast Carcinoma | Epigenetic Alterations | We conducted a microRNA profiling experiment in serum samples from 48 breast cancer patients using Exiqon miRCURY microRNA RT-PCR panels. | 27409424 |
| Breast Carcinoma | Epigenetic Alterations | Using penalized logistic regression, we built a 7-miRNA signature for breast cancer recurrence, which had an excellent discriminating capacity (concordance index=0.914). | 27409424 |
| Breast Carcinoma | Epigenetic Alterations | We also found the 7-miRNA signature were reliably measured across different runs of PCR experiments (intra-class correlation coefficient=0.780) and the signature was significantly higher in breast cancer patients with recurrence than healthy controls (p=1.1x10-5). | 27409424 |
| Breast Carcinoma | Epigenetic Alterations | Significantly differentiated miRNAs for recurrence in the discovery profiling were further validated in an independent set of sera from 20 patients with breast cancer recurrences and 22 patients without recurrences. | 27409424 |
| Breast Carcinoma | Epigenetic Alterations | We identified seven miRNAs that were differentially expressed between breast cancer patients with and without recurrences, including four miRNAs upregulated (miR-21-5p, miR-375, miR-205-5p, and miR-194-5p) and three miRNAs downregulated (miR-382-5p, miR-376c-3p, and miR-411-5p) for recurrent patients. | 27409424 |
| Breast Carcinoma | Epigenetic Alterations | In conclusion, circulating miRNAs are promising biomarkers and the signature may be developed into a minimally invasive multi-marker blood test for continuously monitoring the recurrence of breast cancer. | 27409424 |
| Rheumatoid Arthritis | Epigenetic Alterations | MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. | 27411480 |
| Keratoconus, Glaucoma, CTCAE | Epigenetic Alterations | We also identified uniquely expressed miRNAs, of which five share 18 highly validated gene targets, and created a profile of miRNAs known to target genes associated with keratoconus and glaucoma. | 27415791 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Objective MicroRNA-154 (miR-154) was previously reported to be downregulated in several types of human cancers and may act as a tumour suppressor. | 27417886 |
| Malignant Neoplasms, Ovarian Serous Adenocarcinoma | Epigenetic Alterations | Multiple investigations reported miRNAs aberrantly expressed in several cancers, including high-grade serous ovarian carcinoma (HGS-OvCa). | 27419385 |
| Stomach Carcinoma | Epigenetic Alterations | Circulating microRNA-196a/b are novel biomarkers associated with metastatic gastric cancer. | 27420607 |
| Stomach Carcinoma | Epigenetic Alterations | However, the clinical significance of these microRNAs in gastric cancer (GC) remains to be clarified. | 27420607 |
| Prostate Cancer Pathway | Epigenetic Alterations | As one epigenetic regulation mechanism, DNA methylation of the whole genome and specific gene(s) plays critical roles in pathogenesis, progression, diagnosis, and treatment of prostate cancer. | 27420993 |
| Malignant Neoplasms, Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation level of the E-Cadherin gene could be an important predictive index for malignancy of prostate cancer. | 27420993 |
| cervical cancer | Epigenetic Alterations | A microRNA expression signature for clinical response in locally advanced cervical cancer. | 27423381 |
| cervical cancer | Epigenetic Alterations | These seven validated miRNA signatures could be used as molecular biomarkers of chemo- and radio-resistance in locally advanced cervical cancer patients. | 27423381 |
| Cardiac Arrest | Epigenetic Alterations | Circulating microRNAs and sudden cardiac arrest outcomes. | 27423422 |
| Cardiac Arrest, Ventricular Fibrillation | Epigenetic Alterations | MicroRNAs (miRNAs) have regulatory functions in organs critical in resuscitation from sudden cardiac arrest due to ventricular fibrillation (VF-SCA); therefore, circulating miRNAs may be markers of VF-SCA outcome. | 27423422 |
| Primary malignant neoplasm | Epigenetic Alterations | microRNAs (miRNAs) are small noncoding RNAs that have become potential biomarkers and molecular targets for cancer treatment. | 27427222 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Expression of miRNA-21 and miRNA-221 in clear cell renal cell carcinoma (ccRCC) and their possible role in the development of ccRCC. | 27427222 |
| Neoplasms | Epigenetic Alterations | miRNA-21 and miRNA-221 expressions were significantly up-regulated in tumor specimens compared to normal tissue (P<0.05). | 27427222 |
| Neoplasms | Epigenetic Alterations | Expression of oncogenic miRNA-21 and miRNA-221 in human ccRCC tumor tissue samples compared to adjacent nontumorous tissues might suggest that these miRNAs are involved in the development of ccRCC. | 27427222 |
| Fibromyalgia | Epigenetic Alterations | We found 51 aberrantly expressed miRNAs in white blood cells of patients with FMS, of which miR-let-7d correlated with reduced small nerve fiber density in patients with FMS. | 27429177 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Aberrant microRNA (miRNA) expression has been shown to have a role in CLL pathogenesis; however, a comparison of miRNA expression between CLL cells in the LN and the peripheral blood (PB) has previously not been reported. | 27431016 |
| Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | Ibrutinib downregulates a subset of miRNA leading to upregulation of tumor suppressors and inhibition of cell proliferation in chronic lymphocytic leukemia. | 27431016 |
| Neoplasms | Epigenetic Alterations | These findings demonstrate that ibrutinib downregulates the expression of a subset of miRNAs related to B-cell activation leading to increased expression of miRNA targets including tumor suppressors and a reduction in cell proliferation. | 27431016 |
| Esophageal carcinoma | Epigenetic Alterations | The long noncoding RNA CASC9 regulates migration and invasion in esophageal cancer. | 27431358 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) upregulated in ESCC tissues were detected by RNA sequencing. | 27431358 |
| Breast Carcinoma | Epigenetic Alterations | Prognostic value of microRNA-203a expression in breast cancer. | 27431784 |
| Malignant Neoplasms | Epigenetic Alterations | The single nucleotide polymorphism (SNP) rs6983267 and cancer-associated region long non-coding RNA (CARLo-5) are associated with various human cancers. | 27432114 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | DNA methylation profiling of heterogeneous head and neck squamous cell carcinoma (HNSCC) cohorts has been reported to predict patient outcome. | 27433284 |
| Neoplasms, Trauma Symptom Checklist for Children Questionnaire | Epigenetic Alterations | With genome-scale assessment of DNA methylation using HM450K in one of the largest OTSCC cohorts to date, we were unable to identify a hypermethylated group of tumours or a prognostic methylation signature. | 27433284 |
| Trauma Symptom Checklist for Children Questionnaire | Epigenetic Alterations | This suggests that either DNA methylation in isolation is not likely to be of prognostic value or larger cohorts are required to identify such a biomarker for OTSCC. | 27433284 |
| Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome | Epigenetic Alterations | Epigenetic landscape of the TERT promoter: a potential biomarker for high risk AML/MDS. | 27433923 |
| Prostate Cancer Pathway | Epigenetic Alterations | MicroRNA-21 in peripheral blood mononuclear cells as a novel biomarker in the diagnosis and prognosis of prostate cancer. | 27434290 |
| Neoplasms | Epigenetic Alterations | Exemplarily, gene-specific analyses of DNA methylation, mRNA and protein expression demonstrate lack of expression of the clinically important drug transporter OCT2 (encoded by SLC22A2) in cell lines due to hypermethylation compared to tumors or metastases. | 27435027 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Our findings provide evidence that RCC cell lines are of limited benefit for prediction of drug effects due to epigenetic alterations. | 27435027 |
| Neoplasms | Epigenetic Alterations | Similar epigenetic landscape of ccRCC-metastases and tumors opens new avenue for future therapeutic strategies. | 27435027 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The prognostic value of a seven-microRNA classifier as a novel biomarker for the prediction and detection of recurrence in glioma patients. | 27438144 |
| Glioblastoma Multiforme | Epigenetic Alterations | We hypothesized that the microRNA expression profile may serve as a biomarker for the prognosis and prediction of glioblastoma recurrence. | 27438144 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The seven-miRNA-based classifier should be useful in the stratification and individualized management of patients with glioma. | 27438144 |
| Primary malignant neoplasm, Glioblastoma Multiforme | Epigenetic Alterations | We defined microRNAs that were associated with good and poor prognosis in 300 specimens of glioblastoma from the Cancer Genome Atlas. | 27438144 |
| Malignant Neoplasms, Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Altered expression of microRNAs (miRNAs) has been shown in many types of malignancies including the head and neck squamous cell carcinoma (HNSCC). | 27440205 |
| Hypoxia | Epigenetic Alterations | Investigation as part of a miRNA hypoxia signature may reveal the full potential of miR-210. | 27441495 |
| allergic inflammation | Epigenetic Alterations | Several changes in miRNA expression have been found as a result of the buildup phase of wasp VIT, with lower expression of some miRNAs involved in allergic inflammation and higher expression of those possibly involved in tolerance induction. | 27441833 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The decrease in miRNA-29b expression was statistically significant and differentiated NSCLC histopathological subtypes. | 27447710 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in tumorigenesis and function as oncogenes or tumor suppressor genes. | 27447710 |
| Metastasis, Neoplasms | Epigenetic Alterations | Among other genes, miRNAs regulate matrix metalloproteinases (MMPs), the proteolytic enzymes playing a significant role in the degradation of extracellular matrix, enhancing tumor invasion and metastasis. | 27447710 |
| Carcinogenesis | Epigenetic Alterations | The results of our pilot study indicated the diagnostic potential of miR-29b and MMP-2, an inverse association between miR-26a and MMP-2, and proved the role of MMP-2 and the studied miRNAs in lung carcinogenesis. | 27447710 |
| cervical cancer | Epigenetic Alterations | Seven protective miRNA signatures for prognosis of cervical cancer. | 27447860 |
| cervical cancer | Epigenetic Alterations | TCGA data of patients with cervical cancer were used to build univariate Coxs model with single clinical parameter or miRNA expression level. | 27447860 |
| PRB1 gene | Epigenetic Alterations | Contrarily, DNA methylation genes (DNMT3A, IDH1, IDH2 and TET2) were mutated most often in PV (0*5) and less frequently in ET (0*23) and PMF (0*20), but without reaching statistical significance. | 27447873 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of cancer. | 27449043 |
| Myeloproliferative disease | Epigenetic Alterations | Rapid Molecular Profiling of Myeloproliferative Neoplasms Using Targeted Exon Resequencing of 86 Genes Involved in JAK-STAT Signaling and Epigenetic Regulation. | 27449473 |
| Clinical Coordinator | Epigenetic Alterations | The relationship between the DNA methylation status of the CpG islands of multiple genes in blood leukocytes in CRC susceptibility and prognosis, as well as possible interactions with dietary factors on CRC risk are unclear. | 27453436 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA Expression in a Readily Accessible Common Hepatic Artery Lymph Node Predicts Time to Pancreatic Cancer Recurrence Postresection. | 27456015 |
| palladium | Epigenetic Alterations | Station 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR. | 27456015 |
| Neoplasm of ampulla of Vater | Epigenetic Alterations | We conclude that elevated miRNA-10b levels in station 8 lymph nodes could be utilized to assess risk for early disease progression in patients with periampullary tumors. | 27456015 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-497 downregulation contributes to cell proliferation, migration, and invasion of estrogen receptor alpha negative breast cancer by targeting estrogen-related receptor alpha. | 27456360 |
| Primary malignant neoplasm | Epigenetic Alterations | Knockdown of Long Noncoding RNA PCAT6 Inhibits Proliferation and Invasion in Lung Cancer Cells. | 27458097 |
| Prostate Cancer Pathway, Prostate | Epigenetic Alterations | As a newly identified oncogenic long noncoding RNA (lncRNA), prostate cancer-associated transcript 6 (PCAT6) promoted cellular proliferation and colony formation of prostate cancer. | 27458097 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Immunohistochemical loss of 5-hydroxymethylcytosine expression in acute myeloid leukaemia: relationship to somatic gene mutations affecting epigenetic pathways. | 27458708 |
| Myeloid neoplasm, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Genes affecting epigenetic pathways are frequently mutated in myeloid malignancies, including acute myeloid leukaemia (AML). | 27458708 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic suppression of the immunoregulator MZB1 is associated with the malignant phenotype of gastric cancer. | 27459504 |
| Alzheimers Disease | Epigenetic Alterations | Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimers disease. | 27459923 |
| Angular | Epigenetic Alterations | 5mC and 5hmC were present in a high proportion of neurofibrillary tangles, suggesting no loss of DNA methylation marks in tangle bearing neurons. | 27459923 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | There is increasing evidence that epigenetic alterations may play a role in Alzheimers disease (AD); yet, there is little information regarding epigenetic modifications in specific cell types. | 27459923 |
| Admitting diagnosis | Epigenetic Alterations | We provide evidence that epigenetic dysregulation may be occurring in astrocytes and NF-positive pyramidal neurons in AD. | 27459923 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac. | 27461117 |
| Malignant Neoplasms | Epigenetic Alterations | In addition, it is reported that CLDN6 expression is regulated by DNA methylation in various human cancers and cell lines. | 27461117 |
| Breast Carcinoma | Epigenetic Alterations | Here we show the mechanism by which DNA methylation regulates CLDN6 expression in human breast cancer cell line MCF-7. | 27461117 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Down-expression of circulating micro ribonucleic acid (miRNA)-148/152 family in plasma samples of non-small cell lung cancer patients. | 27461630 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The levels of miRNA-148/152 family were detected by TaqMan quantitative polymerase chain reaction (qPCR) assay in plasma of 20 NSCLC patients and 10 healthy individuals. | 27461630 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The circulating level of all three members of miRNA-148/152 family were significantly lower in plasma samples of NSCLC patients compared with those of healthy controls (P = 0.007, P = 0.003, and P = 0.000, respectively). | 27461630 |
| Malignant Neoplasms | Epigenetic Alterations | Circulating extracellular micro ribonucleic acids (miRNAs) are considered as potential biomarkers for malignancy detection and diagnosis. | 27461630 |
| Occult Lung Non-Small Cell Carcinoma | Epigenetic Alterations | Increased expression of microRNA-301a in nonsmall-cell lung cancer and its clinical significance. | 27461635 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, accumulating evidence indicates that dysregulation of microRNAs is associated with the initiation and progression of cancer. | 27461635 |
| Liver carcinoma | Epigenetic Alterations | Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function. | 27462777 |
| Hollings Cancer Center | Epigenetic Alterations | (1) Four oncogenic miRNAs (miR-151, 155, 191 and 224) with high expression in HCC tissues were selected as candidates. | 27462777 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Our findings provide information on the epigenetic signature of the two major sensitive mutations among NSCLC and add to the understanding of mechanisms underlying the different outcomes. | 27463019 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Plasma MiRNA alterations between NSCLC patients harboring Del19 and L858R EGFR mutations. | 27463019 |
| Neoplasms | Epigenetic Alterations | Levels of DNA Methylation Vary at CpG Sites across the BRCA1 Promoter, and Differ According to Triple Negative and "BRCA-Like" Status, in Both Blood and Tumour DNA. | 27463681 |
| Neoplasms | Epigenetic Alterations | The levels of tumour DNA methylation were significantly higher in triple negative tumours, and in tumours with high BRCA-like histopathological scores (10 of 11 CpG sites; p<0.01 and p<0.007 respectively). | 27463681 |
| Osteoporosis | Epigenetic Alterations | In conclusion, the presence of heavy metals into bone shed new light on the comprehension of the pathogenesis of osteoporosis since these elements could play a non redundant role in the development of osteoporosis at cellular/molecular and epigenetic level. | 27464007 |
| Cardiovascular Diseases | Epigenetic Alterations | More and more evidence indicate that miRNA plays an important role in the pathophysiology of many diseases, especially the occurrence and development of cardiovascular diseases. | 27464494 |
| Pituitary Neoplasms | Epigenetic Alterations | MicroRNA-106b promotes pituitary tumor cell proliferation and invasion through PI3K/AKT signaling pathway by targeting PTEN. | 27465551 |
| Malignant neoplasm of urinary bladder, Neoplasms | Epigenetic Alterations | Alterations of global histone modification levels have been identified in various tumor entities, including bladder cancer (BCA). | 27466500 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Evaluation of Global Histone Acetylation Levels in Bladder Cancer Patients. | 27466500 |
| Malignant neoplasm of urinary bladder, Primary malignant neoplasm | Epigenetic Alterations | Global histone acetylation levels undergo quantitative alterations during bladder cancer progression and could be helpful to identify patients at risk for early cancer recurrence. | 27466500 |
| Unipolar Depression | Epigenetic Alterations | The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression. | 27468165 |
| Mental disorders | Epigenetic Alterations | These findings support a mechanistic role for miRNAs in the regulation of stress-responsive genes disrupted in psychiatric illness. | 27468165 |
| Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | Upregulation of the long non-coding RNA BANCR correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma. | 27470379 |
| Neoplasms | Epigenetic Alterations | Recent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the tumor progression and poor prognosis. | 27470379 |
| Colorectal Neoplasms | Epigenetic Alterations | A Highly Predictive Model for Diagnosis of Colorectal Neoplasms Using Plasma MicroRNA: Improving Specificity and Sensitivity. | 27471839 |
| Colorectal Neoplasms | Epigenetic Alterations | To develop a plasma-based microRNA (miRNA) diagnostic assay specific for colorectal neoplasms, building upon our prior work. | 27471839 |
| Colorectal Neoplasms, Neoplasms | Epigenetic Alterations | Our plasma miRNA assay and prediction model differentiate colorectal neoplasia from patients with other neoplasms and from controls with higher sensitivity and specificity compared with current clinical standards. | 27471839 |
| Clinical Coordinator, Breast Carcinoma, Pancreatic carcinoma, Carcinoma of lung | Epigenetic Alterations | Plasma was screened for 380 miRNAs using microfluidic array technology from a "Training" cohort of 60 patients, (10 each) control, CRC, CAA, breast cancer, pancreatic cancer, and lung cancer. | 27471839 |
| Colorectal Neoplasms | Epigenetic Alterations | We identified uniquely dysregulated miRNAs specific for colorectal neoplasia (P < 0.05, false discovery rate: 5%, adjusted a = 0.0038). | 27471839 |
| Mycosis Fungoides | Epigenetic Alterations | Genomic imbalances and microRNA transcriptional profiles in patients with mycosis fungoides. | 27473081 |
| Hollings Cancer Center | Epigenetic Alterations | Biological and cDNA/miRNA microarray data were compared among CD44-positive/-negative HCC cells and normal hepatic cells. | 27473646 |
| Portal vein structure, Hollings Cancer Center | Epigenetic Alterations | Of the six miRNAs, miR-137 was closely associated with overall and cancer-specific survivals, as well as with invasion of hepatic vein, hepatic artery, portal vein and bile duct, and alpha-foetoprotein in additional 110 HCC patients. | 27473646 |
| Hematologic Neoplasms | Epigenetic Alterations | Epigenetic alteration may play a role in age-associated dysfunction of stem cells and predispose to the development of hematological cancers. | 27475703 |
| Malignant Peripheral Nerve Sheath Tumor, Neoplasms | Epigenetic Alterations | Although loss of the NF1 gene predisposes to MPNST induction, relatively long tumor latency in NF1 patients suggests that additional genetic or epigenetic abnormalities are needed for the development of these nerve sheath malignancies. | 27477693 |
| Huntington Disease | Epigenetic Alterations | Huntingtons disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels. | 27479945 |
| Hodgkin Disease | Epigenetic Alterations | We sought to inquire if HD is associated with an accelerated epigenetic age. | 27479945 |
| Hodgkin Disease | Epigenetic Alterations | Overall, brain regions from HD cases exhibit a significant epigenetic age acceleration effect (p=0.0012). | 27479945 |
| Hodgkin Disease | Epigenetic Alterations | After excluding controls, we observe a negative correlation (r=-0.41, p=5.5x10-8) between HD gene CAG repeat length and the epigenetic age of HD brain samples. | 27479945 |
| Hodgkin Disease | Epigenetic Alterations | In conclusion, HD is associated with an accelerated epigenetic age of specific brain regions and more broadly with substantial changes in brain methylation levels. | 27479945 |
| Neoplasms | Epigenetic Alterations | Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients. | 27484791 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | A prognostic predictor panel with DNA methylation biomarkers for early-stage lung adenocarcinoma in Asian and Caucasian populations. | 27484806 |
| Neoplasms | Epigenetic Alterations | Additionally, miRNA expression was compared between CC and normal colon mucosa samples and between the mismatch repair (MMR) competent and deficient tumours. | 27485175 |
| Neoplasms | Epigenetic Alterations | We assessed by qRT-PCR expression of 754 microRNAs (miRNAs) in tumour samples from 85 stage pT2-3N0 CC patients treated with surgery alone. | 27485175 |
| Neoplasms | Epigenetic Alterations | The expression of several novel miRNAs were found to be tumour specific, e.g. | 27485175 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-610 is downregulated in glioma cells, and inhibits proliferation and motility by directly targeting MDM2. | 27485527 |
| Stomach Carcinoma, Liver carcinoma | Epigenetic Alterations | The expression of microRNA (miR)-610 has previously been reported to be downregulated in gastric cancer and hepatocellular carcinoma. | 27485527 |
| Malignant tumor of colon | Epigenetic Alterations | Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer. | 27485599 |
| Malignant tumor of colon | Epigenetic Alterations | A diagnostic four-microRNA signature consisting of miR-23a-3p, miR-27a-3p, miR-142-5p and miR-376c-3p was established (AUC = 0.917), distinguishing colon cancer patients from healthy donors with sensitivity of 89% and specificity of 81% (AUC = 0.922). | 27485599 |
| Malignant tumor of colon | Epigenetic Alterations | Fifty-four microRNAs were found to be significantly deregulated in serum of colon cancer patients compared to healthy donors (P < 0.01). | 27485599 |
| Malignant tumor of colon | Epigenetic Alterations | This panel of microRNAs exhibited high diagnostic performance also when analyzed separately in colon cancer patients in early stages of the disease (T1-4N0M0; AUC = 0.877). | 27485599 |
| Malignant tumor of colon | Epigenetic Alterations | In summary, highly sensitive signatures of circulating microRNAs enabling non-invasive early detection and prognosis prediction of colon cancer were identified. | 27485599 |
| Carcinoma of lung, Liquid Chromatography | Epigenetic Alterations | Analysis of epigenetic alterations such as methylation of circulating-free DNA (cf-DNA) expression significantly broadened perspectives of lung cancer (LC) screening. | 27485611 |
| Neoplasms | Epigenetic Alterations | DNA methylation, as the most frequent mechanism for gene silencing, has been widely investigated in regards to the development of tumors. | 27485791 |
| Malignant neoplasm of ovary | Epigenetic Alterations | Thus, FBXW7 expression was downregulated in ovarian cancers, and was associated with p53 mutations and the DNA methylation status of the 5-upstream regions of FBXW7. | 27486687 |
| Carcinoma of lung, Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Regulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis. | 27488440 |
| Atrial Fibrillation | Epigenetic Alterations | Oxidized Low-density Lipoprotein (ox-LDL) Cholesterol Induces the Expression of miRNA-223 and L-type Calcium Channel Protein in Atrial Fibrillation. | 27488468 |
| Rheumatic Heart Disease | Epigenetic Alterations | Our results implicate a new molecular mechanism for AF in which miRNA-223 can be used as an biomarker of AF rheumatic heart disease. | 27488468 |
| Non-Small Cell Lung Carcinoma, Neoplasm Metastasis | Epigenetic Alterations | Collectively, our data suggest that histone modifications play a major role leading to epigenetic silencing of GAS5-AS1 in NSCLC and subsequently promote tumor metastasis via upregulation of several key EMT markers. | 27489122 |
| Non-Small Cell Lung Carcinoma, Neoplasm Metastasis | Epigenetic Alterations | Downregulation of the long noncoding RNA GAS5-AS1 contributes to tumor metastasis in non-small cell lung cancer. | 27489122 |
| Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNA (lncRNA) plays pivotal roles in cancer development. | 27489122 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Distinctive microRNA expression in early stage nasopharyngeal carcinoma patients. | 27489139 |
| Prostate Cancer Pathway | Epigenetic Alterations | The utility of urine-circulating miRNAs for detection of prostate cancer. | 27490805 |
| Prostatic Hyperplasia, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The abundance of selected miRNAs was analysed in urine specimens from two independent cohorts of patients with PCa (N=215 overall), benign prostatic hyperplasia (BPH; N=23), and asymptomatic controls (ASC; N=62) by means of quantitative reverse transcription PCR. | 27490805 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Over 100 miRNAs were found deregulated in PCa as compared with non-cancerous prostate tissue. | 27490805 |
| Squamous cell carcinoma | Epigenetic Alterations | WT1, MSH6, GATA5 and PAX5 as epigenetic oral squamous cell carcinoma biomarkers - a short report. | 27491556 |
| SERPINB3 wt Allele | Epigenetic Alterations | To the best of our knowledge, this is the first study that highlights this specific set of genes as epigenetic diagnostic and prognostic biomarkers in OSCC. | 27491556 |
| Ulcerative Colitis, Inflammation | Epigenetic Alterations | A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation. | 27492330 |
| Clinical Coordinator | Epigenetic Alterations | DNA methylation changes have been regarded as promising biomarkers for CRC diagnosis. | 27493446 |
| Clinical Coordinator | Epigenetic Alterations | Here, we map DNA methylation profiling on CRC in six CRCs and paired normal samples using a 450 K bead array. | 27493446 |
| Clinical Coordinator | Epigenetic Alterations | Our data suggests that aberrant DNA methylation of ADD2 and AKR1B1 could be potential screening markers of CRC. | 27493446 |
| Stomach Carcinoma | Epigenetic Alterations | Thus, our results demonstrate that expression of ADAMTS8 mRNA is significantly decreased and DNA methylation is frequent in gastric cancer. | 27493958 |
| Liver carcinoma | Epigenetic Alterations | MiRNA-22 inhibits oncogene galectin-1 in hepatocellular carcinoma. | 27494859 |
| Hollings Cancer Center | Epigenetic Alterations | On the other hand, galectin-1 and miRNA-22 (miR-22) are dysregulated in HCC and serve as prognostic indicators for patients. | 27494859 |
| Primary Neoplasm | Epigenetic Alterations | Twelve patients with lymph node metastases were included for comparison, and the sum value of the DDCt of 5 miRNAs between primary tumors and lymph node metastases was <9. | 27495091 |
| Glioma | Epigenetic Alterations | MiRNA expression profiling in human gliomas: upregulated miR-363 increases cell survival and proliferation. | 27495233 |
| Astrocytoma, Glioblastoma Multiforme, Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Multiplex real-time PCR was used to profile miRNA expression in a set of World Health Organization (WHO) grade I (pilocytic astrocytoma), II (diffuse fibrillary astrocytoma), and IV (glioblastoma multiforme) astrocytic tumors and primary glioma cell cultures. | 27495233 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | miRNA microarray showed that a set of miRNAs was consistently upregulated in all glioma samples. | 27495233 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The role of microRNAs (miRNAs) in glioma biology is increasingly recognized. | 27495233 |
| Septicemia, Diabetes Mellitus | Epigenetic Alterations | Patients with and without diabetes mellitus, who had sepsis demonstrated similar transcriptional alterations, comprising 74 % of the expressed gene content and involving over-expression of genes associated with pro-inflammatory, anti-inflammatory, Toll-like receptor and metabolic signaling pathways and under-expression of genes associated with T cell signaling pathways. | 27495247 |
| Primary malignant neoplasm, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1. | 27495872 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Herein, we demonstrated that miR-187-5p is a tumor-suppressor miRNA in NSCLC progression. | 27495872 |
| Hypoxia, Neoplasms | Epigenetic Alterations | Long intergenic noncoding RNA-p21 (lincRNA-p21) is a long noncoding RNA transcriptionally activated by tumor protein p53 (TP53) and hypoxia inducible factor 1 alpha subunit (HIF1A). | 27496652 |
| Coronary Artery Disease, Angina Pectoris | Epigenetic Alterations | Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris. | 27497911 |
| Acute myocardial infarction | Epigenetic Alterations | As an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as a potential biomarker of acute myocardial infarction. | 27497911 |
| Rheumatoid Arthritis | Epigenetic Alterations | MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis. | 27498552 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Fibroblast-like synoviocytes (FLS) with aberrant expression of microRNA (miRNA) are critical pathogenic regulators in rheumatoid arthritis (RA). | 27498552 |
| Arthritis | Epigenetic Alterations | Previous studies have found that overexpression or silencing of miRNA can contribute to the development of miRNA-based therapeutics in arthritis models. | 27498552 |
| Carcinogenesis | Epigenetic Alterations | Taken together, these observations demonstrates a novel epigenetic feedback loop between miR-200c and DNMT3a in the carcinogenesis and progression of GC. | 27498672 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant methylation of miRNAs is commonly observed in cancers. | 27498672 |
| Neoplasms | Epigenetic Alterations | High-throughput sequencing was used to detect the genetic and microRNA (miRNA) levels of tumor tissues. | 27498785 |
| Metastasis, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-140 represses glioma growth and metastasis by directly targeting ADAM9. | 27498787 |
| Malignant Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNAs (miRNAs) have been demonstrated to play important roles in the initiation and progression of various types of human cancers, also including glioma. | 27498787 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs are a class of small endogenous non-coding RNAs that play crucial roles in the initiation and progression of human cancers. | 27498924 |
| Metastasis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non-small cell lung cancer. | 27498924 |
| Alzheimers Disease | Epigenetic Alterations | Can Peripheral MicroRNA Expression Data Serve as Epigenomic (Upstream) Biomarkers of Alzheimers Disease? | 27501295 |
| Admitting diagnosis | Epigenetic Alterations | Little is known, however, on the extent to which peripheral tissue (e.g., whole blood) miRNA variation might offer clinical predictive value for AD. | 27501295 |
| Admitting diagnosis | Epigenetic Alterations | Notably, these miRNAs are situated "upstream" to the genes implicated in AD. | 27501295 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression. | 27501756 |
| Malignant Neoplasms, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Recently, long noncoding RNAs (lncRNAs) have been identified as critical regulators in numerous types of cancers, including non-small cell lung cancer (NSCLC). | 27501756 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Circulating microRNA-1290 as a novel diagnostic and prognostic biomarker in human colorectal cancer. | 27502702 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Circulating microRNAs (miRNAs) are attracting major interest as potential non-invasive biomarkers for colorectal cancer (CRC). | 27502702 |
| Carcinoma of lung, Cancer Pain | Epigenetic Alterations | Comparison and combination of blood DNA methylation at smoking-associated genes and at lung cancer-related genes in prediction of lung cancer mortality. | 27503000 |
| Heart failure | Epigenetic Alterations | MicroRNAs (miRs) regulate gene expression in heart failure. | 27505319 |
| Epilepsy | Epigenetic Alterations | Our results also suggest for the first time that dysregulation of DNA methylation found in epilepsy is a cause rather than a consequence of this condition. | 27505431 |
| Matrix Metalloproteinase 9 | Epigenetic Alterations | Epigenetics of Epileptogenesis-Evoked Upregulation of Matrix Metalloproteinase-9 in Hippocampus. | 27505431 |
| Malignant Neoplasms, Carcinoma of lung, Neoplasms | Epigenetic Alterations | MiR-30c-2* is considered to be a tumor suppressor microRNA in various cancers and is associated with gemcitabine sensitivity of lung cancer cells. | 27506865 |
| Primary malignant neoplasm | Epigenetic Alterations | The level of long interspersed nucleotide element-1 (LINE- 1) methylation is considered a surrogate marker of global DNA methylation, and is attracting interest as a good predictor of cancer prognosis. | 27507047 |
| Primary malignant neoplasm | Epigenetic Alterations | However, the mechanism how LINE-1 (global DNA) methylation is controlled in cancer cells remains to be fully elucidated. | 27507047 |
| Primary malignant neoplasm | Epigenetic Alterations | Our results suggest that UHRF1 is a key epigenetic regulator of DNA methylation and might be a potential target for cancer treatment. | 27507047 |
| Metastasis, Malignant neoplasm of thyroid | Epigenetic Alterations | Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF-b/Smad signaling pathway. | 27507052 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Blood-borne miRNA profile-based diagnostic classifier for lung adenocarcinoma. | 27507195 |
| Carcinoma of lung, Blood Circulation | Epigenetic Alterations | Accumulated evidence indicates that various types of miRNA are aberrantly expressed in lung cancer and secreted into the bloodstream. | 27507195 |
| Carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | Interestingly, this classifier also detected squamous and large cell lung carcinoma cases at relatively high rates (70.4% and 70.0%, respectively), which appears to be consistent with organ site-dependent miRNA expression in cancer tissues. | 27507195 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Integrated Epigenomics Analysis Reveals a DNA Methylation Panel for Endometrial Cancer Detection Using Cervical Scrapings. | 27507616 |
| Malignant neoplasm of endometrium, Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is a promising cancer biomarker, but limited use for detecting endometrial cancer. | 27507616 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic modifications are involved in the pathogenesis of cancer, and histone deacetylase inhibitors are considered potential therapeutic agents. | 27507654 |
| Prostate Cancer Pathway, Secondary malignant neoplasm of bone | Epigenetic Alterations | There is an increasing concern in the role of microRNA (miRNA) in the pathogenesis of bone metastasis (BM) secondary to prostate cancer (CaP). | 27509989 |
| Prostate Cancer Pathway | Epigenetic Alterations | Targeted genes would be upregulated upon transfection of the bone metastatic prostate cancer cell line, PC3, with specific microRNA inhibitors. | 27509989 |
| Primary Biliary Cholangitis | Epigenetic Alterations | It has been previously reported that miRNAs are involved in drug resistance, however, the association between miRNA expression levels and refractory PBC remains to be fully elucidated. | 27511723 |
| Neoplasms | Epigenetic Alterations | Prognostic value of long non-coding RNA UCA1 in human solid tumors. | 27517147 |
| Childhood Leukemia | Epigenetic Alterations | We also demonstrate that endogenous linc-223 localizes in the cytoplasm and acts as a competing endogenous RNA for miR-125-5p, an oncogenic microRNA in leukemia. | 27517498 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Site-specific associations between miRNA expression and survival in colorectal cancer cases. | 27517623 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Thus, miRNA expression may alter survival after diagnosis with colorectal cancer (CRC). | 27517623 |
| Malignant tumor of colon | Epigenetic Alterations | Two miRNAs infrequently expressed in the population and not previously reported were associated with survival after diagnosis with colon cancer (miR-1 HR 2.17 95% CI 1.41, 3.36; and miR-101-3p HR 3.51 95% CI 1.72, 7.15). | 27517623 |
| Primary malignant neoplasm | Epigenetic Alterations | Among those diagnosed with rectal cancer, 201 miRNAs were associated with survival when the FDR q value was < 0.05. | 27517623 |
| Malignant tumor of colon, Rectal Carcinoma | Epigenetic Alterations | Assessment of 105 previously reported miRNAs associated with prognosis showed that four miRNAs influenced colon cancer survival and 17 influenced survival after a diagnosis with rectal cancer when raw p values were considered. | 27517623 |
| Colorectal Carcinoma, Rectal Carcinoma | Epigenetic Alterations | MiRNAs dysregulated for both colon and rectal cancer had a greater impact on survival after a diagnosis with rectal cancer. | 27517623 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Downregulation of microRNA-199b predicts unfavorable prognosis and emerges as a novel therapeutic target which contributes to PP2A inhibition in metastatic colorectal cancer. | 27517624 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | The tumor suppressor microRNA-199b (miR-199b) is a negative SET regulator associated with poor outcome in some human cancers. | 27517624 |
| Acute Coronary Syndrome, Hyperglycemia | Epigenetic Alterations | Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages. | 27519051 |
| CO-methylating acetyl-CoA synthase activity | Epigenetic Alterations | MiR-223 and miR-486 prevailed in HDL2, while miR-92a predominated in HDL3, all three miRNAs discriminating between ACS and SA patients; their levels were increased in HDL from hyperglycemic ACS patients versus normoglycemic ones. | 27519051 |
| Primary malignant neoplasm | Epigenetic Alterations | Compared with The Cancer Genome Atlas, we found higher mutation rates in genes encoding products involved in epigenetic regulation and cell cycle regulation. | 27520487 |
| Colorectal Neoplasms | Epigenetic Alterations | We analyzed DNA methylation profiles of the digestive tract surface and the central bulk and invasive front regions of colorectal tumors. | 27521480 |
| Secondary malignant neoplasm of liver, Colorectal Neoplasms | Epigenetic Alterations | We determined the DNA methylation profiles of >450,000 CpG sites in 3 macrodissected regions of 79 colorectal tumors and 23 associated liver metastases, obtained from 2 hospitals in Spain. | 27521480 |
| Neoplasms | Epigenetic Alterations | We observed differences in DNA methylation among the 3 tumor sections; regions of tumor-host interface differed the most from the other tumor sections. | 27521480 |
| Local-Regional anatomy, Neoplasms | Epigenetic Alterations | Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-Free and Overall Survival Times for Patients With Locoregional Cancer. | 27521480 |
| Colorectal Cancer Pathway | Epigenetic Alterations | When we calculated individual coefficients to quantify heterogeneity, we found that epigenetic homogeneity was significantly associated with short time of relapse-free survival (log-rank P = .037) and short time of overall survival (log-rank P = .026) in patients with locoregional colorectal cancer. | 27521480 |
| Proteinuria, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Our findings suggest that microRNA-217 may have an association with the development of proteinuria in type 2 diabetes patients. | 27522360 |
| Diabetic Nephropathy, Inflammation, Fibrosis Assessment | Epigenetic Alterations | Serum microRNA-217 may be involved in the development of diabetic kidney disease by promoting chronic inflammation, renal fibrosis, and angiogenesis. | 27522360 |
| Alzheimers Disease | Epigenetic Alterations | Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimers disease brain. | 27522519 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Serum microRNA-135a downregulation as a prognostic marker of non-small cell lung cancer. | 27525941 |
| Prostate Cancer Pathway | Epigenetic Alterations | MicroRNA-132/212 Upregulation Inhibits TGF-b-Mediated Epithelial-Mesenchymal Transition of Prostate Cancer Cells by Targeting SOX4. | 27527117 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR, Metastasis | Epigenetic Alterations | Accumulating evidence indicates that miRNAs play critical roles in prostate cancer (PCa) metastasis and have potential use as therapeutic targets. | 27527117 |
| Neoplasms | Epigenetic Alterations | Herein we assessed the contribution of the AID/APOBEC family and their associated genes given the remarkable ability of AID and APOBECs to edit DNA/RNA, and as such, providing tools for genetic and epigenetic alterations potentially leading to reprogramming of tumor cells, stroma and immune cells. | 27527602 |
| Muscular Dystrophy, Duchenne | Epigenetic Alterations | Serum Levels of MicroRNA-206 and Novel Mini-STR Assays for Carrier Detection in Duchenne Muscular Dystrophy. | 27529242 |
| Stomach Carcinoma | Epigenetic Alterations | Expression and prognostic value of microRNA-26a and microRNA-148a in gastric cancer. | 27529338 |
| Liver neoplasms, Hollings Cancer Center | Epigenetic Alterations | Here, we compared N-glycan profiles of liver tumor tissues and adjacent tissues of 27 HCC patients to reveal the association between fucosylation and HCC progression, as well as verified the potential role of miRNA in regulating fucosylation. | 27533464 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | Comprehensive N-glycan profiles of hepatocellular carcinoma reveal association of fucosylation with tumor progression and regulation of FUT8 by microRNAs. | 27533464 |
| Hollings Cancer Center | Epigenetic Alterations | The forced expression of these miRNAs was able to induce a decrease in FUT8 levels and thereby to suppress HCC cells progression. | 27533464 |
| melanoma | Epigenetic Alterations | MicroRNA-21 regulates the ERK/NF-kB signaling pathway to affect the proliferation, migration, and apoptosis of human melanoma A375 cells by targeting SPRY1, PDCD4, and PTEN. | 27533779 |
| diabetic | Epigenetic Alterations | Epigenetic modification of the E-cadherin promoter was observed in leukocytes from diabetic subjects. | 27534967 |
| ibudilast | Epigenetic Alterations | miRNA alterations correlate with IBD phenotype, apparently by controlling the down-regulation of specific mRNAs. | 27536783 |
| Ulcerative Colitis | Epigenetic Alterations | MicroRNAs Expression in the Ileal Pouch of Patients with Ulcerative Colitis Is Robustly Up-Regulated and Correlates with Disease Phenotypes. | 27536783 |
| ibudilast | Epigenetic Alterations | microRNAs (miRNAs) are dominant in the regulation of gene expression, and may affect IBD phenotype. | 27536783 |
| Carcinogenesis | Epigenetic Alterations | Abnormal DNA methylation is also known to play a crucial role in colorectal carcinogenesis. | 27540971 |
| Neoplasms | Epigenetic Alterations | Urothelial cancer-associated 1 (UCA1) had been reported as the oncogenic long non-coding RNA in many tumors, but the role of UCA1 in EC is still unclear. | 27540975 |
| Breast Carcinoma, Best Case Imputation Technique | Epigenetic Alterations | Long non-coding RNA (lncRNA) H19 has been well studied playing an important role in breast cancer (BC) progress and the expression of H19 may service as a diagnostic target for BC. | 27540977 |
| Admitting diagnosis | Epigenetic Alterations | As baseline population-specific epigenetic changes, that is, cytosine modifications, have been observed between AD and ED individuals, epigenetic variations in MYLK may provide insights into ARDS disparities. | 27543902 |
| Non-Malignant | Epigenetic Alterations | Validation of the SHOX2/PTGER4 DNA Methylation Marker Panel for Plasma-Based Discrimination between Patients with Malignant and Nonmalignant Lung Disease. | 27544059 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation biomarkers are valuable noninvasive diagnostic tools for cancer detection. | 27544059 |
| Laryngeal Squamous Cell Carcinoma | Epigenetic Alterations | MicroRNA-21 in laryngeal squamous cell carcinoma: Diagnostic and prognostic features. | 27545281 |
| Laryngeal Squamous Cell Carcinoma | Epigenetic Alterations | MicroRNA-21 was upregulated in laryngeal squamous cell carcinomas compared to adjacent nontumor tissues (P = .005). | 27545281 |
| Ischemic stroke | Epigenetic Alterations | However, there has been little research regarding miRNA expression and its involvement in ischemic stroke. | 27545688 |
| Cerebrovascular accident | Epigenetic Alterations | Also, large and small arterial strokes types demonstrated elevated miRNA-34a-5p expression levels. | 27545688 |
| Cerebral artery occlusion | Epigenetic Alterations | Moreover, in vivo experiment results showed significant up-regulated expression of miRNA-34a-5p in middle cerebral artery occlusion compared to controls, along with a positive correlation between miRNA-34a-5p in blood and brain (r=0.742, p<0.05). | 27545688 |
| Cerebrovascular accident, Ischemic stroke | Epigenetic Alterations | CONCLUSIONS Our results suggest there is a potential regulatory role of miRNA-34a-5p in acute ischemic stroke, which could serve as a therapeutic target or biomarker in stroke prognosis. | 27545688 |
| melanoma, Mucosal Melanoma, Concomitant Medication Submission Domain, Methyl Methanesulfonate | Epigenetic Alterations | As opposed to cutaneous melanoma, the epigenetic mechanisms involved in the development of CM and other mucosal melanomas (MMs) are unclear. | 27548891 |
| Malignant melanoma of conjunctiva | Epigenetic Alterations | MicroRNA Expression Profile in Conjunctival Melanoma. | 27548891 |
| Metastasis | Epigenetic Alterations | Changes in miRNA expression were associated with T stage, local recurrence, metastasis, and mortality. | 27548891 |
| Concomitant Medication Submission Domain, melanoma | Epigenetic Alterations | Our analysis revealed 24 upregulated and 1 downregulated miRNA in CM; several of these miRNAs have key functions in the pathogenesis and progression of cutaneous melanoma. | 27548891 |
| Concomitant Medication Submission Domain | Epigenetic Alterations | Furthermore, the miRNA expression pattern of CM resembled that in MM. | 27548891 |
| Concomitant Medication Submission Domain, Neoplasms | Epigenetic Alterations | Additionally, we identified seven upregulated miRNAs specific for stage-T1 and stage-T2 CM, whose expression was associated with increased tumor thickness (P = 0.007), and two upregulated miRNAs (miR-3687 and miR-3916) associated with an increased risk of local recurrence. | 27548891 |
| Concomitant Medication Submission Domain | Epigenetic Alterations | We identified differentially expressed and potentially prognostic miRNAs in CM. | 27548891 |
| Clear-cell metastatic renal cell carcinoma, Metastasis | Epigenetic Alterations | Epithelial-mesenchymal transition-associated microRNA/mRNA signature is linked to metastasis and prognosis in clear-cell renal cell carcinoma. | 27549611 |
| Hemorrhagic Fever, Crimean | Epigenetic Alterations | MicroRNA expression profiles in patients with acute Crimean Congo hemorrhagic fever reveal possible adjustments to cellular pathways. | 27551771 |
| Communicable Diseases, Virus Diseases | Epigenetic Alterations | Several viral diseases are associated with altered microRNA (miRNA) expression, which can provide vital information about how cellular pathways respond to infection. | 27551771 |
| Hantavirus Infections, Dengue Fever | Epigenetic Alterations | Several miRNAs associated with cytokine expression, some of which were previously associated with Dengue and Hantavirus infections were revealed. | 27551771 |
| Osteoporosis, Postmenopausal, Fracture | Epigenetic Alterations | Circulating microRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures. | 27552543 |
| Unknown (origin) (qualifier value) | Epigenetic Alterations | Evaluation of circulating miRNA signatures in male and female subjects with idiopathic and postmenopausal osteoporotic low-traumatic fractures. | 27552543 |
| Osteoporotic Fractures | Epigenetic Alterations | In particular, miR-29b-3p has previously been reported as regulator of osteogenic differentiation and could serve as a novel marker of bone turnover in osteoporotic patients as a member of a miRNA signature. | 27552543 |
| Head and Neck Carcinoma | Epigenetic Alterations | Aberrations in Wnt and Shh signaling pathways are related to the pathogenesis of head and neck carcinomas, and their activation frequently results from epigenetic alterations. | 27553089 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Our findings corroborate that the activation of Wnt signaling in head and neck squamous cell carcinoma (HNSCC) is related to epigenetic silencing of its negative regulators. | 27553089 |
| Prostate Cancer Pathway, Metastasis | Epigenetic Alterations | The up-regulation of long non-coding RNA CCAT2 indicates a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial-mesenchymal transition. | 27558961 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in human cancer biology. | 27558961 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Circulating Tumor Cells in Breast Cancer: Correlation with Clinicopathological Parameters, Hormone Profile and MicroRNA Polymorphisms. | 27562388 |
| Neoplasms | Epigenetic Alterations | No significant associations between pre-miRNA genetic variations miR-196a2 C/T (rs11614913), miR-146a G/C (rs2910164) and miR-499 T > C (rs3746444) polymorphisms and circulating tumor cell positivity were observed. | 27562388 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant expression of miRNA (miR)-139-5p has been observed in various types of cancers. | 27562849 |
| Primary malignant neoplasm | Epigenetic Alterations | Emerging evidence suggested that microRNAs (miRNAs) play a causal role in cancer tumorigenesis. | 27562849 |
| Obesity | Epigenetic Alterations | Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. | 27564309 |
| Obesity | Epigenetic Alterations | We conclude that epigenetic modulation of SOCS3, a gene involved in leptin and insulin signaling, may play an important role in obesity and MetS. | 27564309 |
| Neoplasms | Epigenetic Alterations | We demonstrate intra-tumor expression gradients indicating a differentiated expression of the target miRNAs between functional tumor zones, but the potential role as markers of early metastatic disease is still not fully clarified. | 27565378 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The expression of microRNA 574-3p as a predictor of postoperative outcome in patients with esophageal squamous cell carcinoma. | 27565418 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Our results suggest that the aberrant expression of the miRNAs identified in this study plays key roles in the progression of ESCC. | 27565418 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Plasma microRNA profiles: identification of miR-23a as a novel biomarker for chemoresistance in esophageal squamous cell carcinoma. | 27566562 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic changes in localized gastric cancer: the role of RUNX3 in tumor progression and the immune microenvironment. | 27566570 |
| Stomach Carcinoma | Epigenetic Alterations | Gastric cancer (GC) pathogenesis involves genetic, epigenetic and environmental factors. | 27566570 |
| Primary malignant neoplasm | Epigenetic Alterations | RUNX3 showed protein silencing in cancer and normal mucosa, compared to inflammatory peritumoural infiltrate in almost all cases, showing a non-lymphocytic predominant pattern and being correlated with epigenetic silencing.Our results show aberrant promoters methylation in APC, CDH1, CDKN2A, MLH1 and RUNX3 associated with GC, as well as a non-lymphocytic predominant infiltrate with high expression of RUNX3. | 27566570 |
| Primary malignant neoplasm | Epigenetic Alterations | Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer. | 27566576 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation was regarded as the promising biomarker for rectal cancer diagnosis. | 27566576 |
| Primary malignant neoplasm | Epigenetic Alterations | To identify new molecular markers for rectal cancer, we mapped DNA methylation and transcriptomic profiles in the six rectal cancer and paired normal samples. | 27566576 |
| Primary malignant neoplasm | Epigenetic Alterations | Our data suggests that aberrant DNA methylation of contiguous CpG sites in methylation array may be potential diagnostic markers of rectal cancer. | 27566576 |
| FLT3 Internal Tandem Duplication | Epigenetic Alterations | We found that patients with activating mutations, such as FLT3-ITD, had shorter TL, while those with mutations in epigenetic modifying enzymes, particularly IDH1 and IDH2, had longer TL. | 27568819 |
| Glioma | Epigenetic Alterations | Reduced expression of microRNA-497 is associated with greater angiogenesis and poor prognosis in human gliomas. | 27569294 |
| Malignant Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA (miR)-497 plays a tumor-suppressive role in several malignancies and is involved in glioma invasiveness and resistance to chemotherapy. | 27569294 |
| Embryonic Mosaic | Epigenetic Alterations | Our study suggests that mechanisms in addition to X chromosome inactivation, such as germline mosaicism or epigenetics, may contribute to DC-like phenotypes present in female DKC1 mutation carriers. | 27570172 |
| MS gene | Epigenetic Alterations | Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells. | 27570566 |
| SF3B1 wt Allele | Epigenetic Alterations | Here, we tried to identify the miRNAs-regulated pathways through a combination of miRNA and mRNA microarray in CD34+ cells from MDS patients. | 27571714 |
| SF3B1 wt Allele | Epigenetic Alterations | We identified 34 differentially expressed miRNAs and 1783 mRNAs in MDS. | 27571714 |
| SF3B1 wt Allele | Epigenetic Alterations | In conclusion, alteration expression of miRNAs and targeted mRNAs might have an important impact on cancer-related cellular pathways in MDS. | 27571714 |
| Neoplasms | Epigenetic Alterations | MicroRNA (miRNA) expression is shown dysregulated in tumors. | 27571748 |
| Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-45 (miR-145) has been demonstrated to be downregulated in various cancer types including colorectal cancer (CRC). | 27572146 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Taken together, our results indicate that decreased ER expression mediated by DNA methylation may play a role in NSCLC development. | 27572263 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | miRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancer. | 27572271 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating serum microRNA-345 correlates with unfavorable pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer. | 27572313 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3. | 27572553 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miRNA) clusters are expressed universally across different types of organisms, and an accumulating number of studies have demonstrated that miRNA clusters function more efficiently compared with single miRNAs during the development of certain cancer types. | 27572636 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Promoter hypermethylation was previously observed in NSCLC, and its epigenetic silencing, observed on mRNA or protein level, was proposed to predict NSCLC outcome. | 27572663 |
| Primary malignant neoplasm, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | FHIT promoter hypermethylation both in cancer and control tissue indicated the presence of epigenetic alterations in early stage of NSCLC development. | 27572663 |
| Aggressive behavior, Glioblastoma Multiforme | Epigenetic Alterations | Expression level of miRNAs on chromosome 14q32.31 region correlates with tumor aggressiveness and survival of glioblastoma patients. | 27573219 |
| Glioblastoma, Neoplasms | Epigenetic Alterations | These miRNAs are downregulated in glioblastomas and might have a tumor suppressive role. | 27573219 |
| Glioblastoma Multiforme | Epigenetic Alterations | We also determined the expression level of cluster-14-miRNAs in 27 patients with newly diagnosed glioblastoma, and analyzed the association between their level of expression and OS. | 27573219 |
| Aggressive behavior, Glioblastoma Multiforme | Epigenetic Alterations | The expression level of cluster-14-miRNAs correlates directly with OS, suggesting a role for this cluster in promoting aggressive behavior of glioblastoma, possibly through ErBb/neuregulin signaling. | 27573219 |
| melanoma | Epigenetic Alterations | Increasing evidence shows that miRNA can provide potential candidate biomarkers for melanoma and therapeutic targets. | 27573550 |
| Liver and Intrahepatic Biliary Tract Carcinoma | Epigenetic Alterations | Supposing that microRNA (miRNA) expression profiles in saliva are similar to those in serum, four miRNAs (miR-1246, miR-3976, miR-4306, and miR-4644) in salivary exosomes may also be useful for detection of pancreatobiliary tract cancer. | 27573701 |
| Squamous cell carcinoma, methionine | Epigenetic Alterations | The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma. | 27573718 |
| Primary malignant neoplasm | Epigenetic Alterations | Restoration of miR-23b or miR-27b in cancer cells revealed that both miRNAs significantly inhibited cancer cell migration and invasion. | 27573718 |
| Adenocarcinoma | Epigenetic Alterations | A comparison of miRNA profiles revealed 29 miRNAs that were differentially expressed between TRU- and non-TRU adenocarcinoma types. | 27575252 |
| Adenocarcinoma, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | TRU- and non-TRU-type adenocarcinomas have distinct miRNA expression profiles, suggesting that tumorigenesis in lung adenocarcinoma occur via different pathways. | 27575252 |
| Prostate Cancer Pathway, Carcinogenesis | Epigenetic Alterations | Characterizing aberrant DNA methylation changes associated with prostate carcinogenesis could potentially identify a tumour-specific methylation pattern, facilitating the early diagnosis of prostate cancer. | 27576364 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic silencing mediated by CpG island methylation is a common feature of many cancers. | 27576364 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA. | 27577081 |
| Neoplasms | Epigenetic Alterations | DNA methylation changes in peripheral blood DNA have been shown to be associated with solid tumors. | 27577081 |
| Cell Invasion | Epigenetic Alterations | MicroRNA-3713 regulates bladder cell invasion via MMP9. | 27577949 |
| Malignant Neoplasms | Epigenetic Alterations | Dysregulation of microRNAs (miRNAs) is well known to be involved in the development of various cancers, including TCC, whereas a role of miR-3713 in the pathogenesis of TCC has not been appreciated. | 27577949 |
| Primary malignant neoplasm | Epigenetic Alterations | The Piwi-piRNA pathway is important for germ cell maintenance, genome integrity, DNA methylation and retrotransposon control and thus may be involved in cancer development. | 27578485 |
| Squamous cell carcinoma, Neoplasms | Epigenetic Alterations | We previously described several abnormally expressed long non-coding RNA (lncRNA) in tong squamous cell carcinomas (TSCCs) that might be associated with tumor progression. | 27586393 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | We assessed the performance of associating a FGFR3 mutation assay and a DNA methylation analysis to improve bladder cancer detection and to predict disease recurrence of NMIBC patients. | 27586786 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Non-muscle-invasive bladder cancer (NMIBC) is a high incidence form of bladder cancer (BCa), where genetic and epigenetic alterations occur frequently. | 27586786 |
| Pancreatic Intraductal Papillary Mucinous Neoplasm | Epigenetic Alterations | Combining radiomic features with a miRNA classifier may improve prediction of malignant pathology for pancreatic intraductal papillary mucinous neoplasms. | 27589689 |
| Acute Coronary Syndrome | Epigenetic Alterations | The role of serum levels of microRNA-21 and matrix metalloproteinase-9 in patients with acute coronary syndrome. | 27590242 |
| Cardiovascular Diseases | Epigenetic Alterations | It seems that microRNA-21 and matrix metalloproteinase-9 implicated in the pathogenesis of cardiovascular diseases. | 27590242 |
| Metastasis, Neoplasms | Epigenetic Alterations | A growing body of research has shown that the dynamic expression of microRNAs (miRNAs) was intimately associated with tumor invasion and metastasis. | 27593563 |
| Systemic arterial pressure, Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | Increasing evidence suggests that the early life environment may act through epigenetic processes to influence later CHD risk markers such as increased arterial pulse wave velocity (PWV, a measure of arterial stiffness) blood pressure or heart rate. | 27594927 |
| Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | Our findings suggest developmental epigenetic regulation of ANRIL promoter methylation as a factor in later CHD risk in children. | 27594927 |
| Complication Aspects, PRB1 gene | Epigenetic Alterations | Taken together, our findings suggest a possible role of CD18 epigenetic regulation in the pathogenesis of the thrombotic complications in PMF patients. | 27595148 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNAs (miRNA) are believed to play an important role in glioblastoma multiforme (GBM)chemotherapy. | 27595933 |
| Neoplasms | Epigenetic Alterations | miRNA-370-3p mimic increased its expression and sensitivity of GBM cells to TMZ by suppressing the self-reparative ability of tumour cell DNA. | 27595933 |
| Malignant Neoplasms | Epigenetic Alterations | miRNAs have been reported to be involved in the pathogenesis of many cancers. | 27596960 |
| Malignant Neoplasms, fluorouracil/mitomycin/streptozocin | Epigenetic Alterations | Here, expression deregulation of 7 miRNAs (mir204, mir31, mir31*, mir133a, mir7, mir206 and mir1293) and their possible target genes in 23 cancers, 18 LK, 12 LP, 23 OSMF tissues compared to 20 healthy tissues was determined by qPCR method. | 27597234 |
| Stomach Carcinoma | Epigenetic Alterations | Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer. | 27598141 |
| Stomach Carcinoma | Epigenetic Alterations | Therapeutic intervention of STAT3 in reversing the epigenetic status of GATA6 could benefit the treatment of gastric cancer and is worthy of further investigation. | 27598141 |
| Primary malignant neoplasm | Epigenetic Alterations | Although its contents (e.g., proteins and microRNAs) have been focused on in cancer research, particularly as potential diagnostic markers, the exosome behavior and methods for exosome quantification remain unclear. | 27599779 |
| Prostate Cancer Pathway | Epigenetic Alterations | Circulating microRNA signature for the diagnosis of very high-risk prostate cancer. | 27601638 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | We report the identification of a molecular signature using the Scano-miR profiling platform based on the differential expression of circulating microRNAs (miRNA, miR) in serum samples specific to patients with very high-risk (VHR) prostate cancer (PCa). | 27601638 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Five miRNA PCa biomarkers (miR-200c, miR-605, miR-135a*, miR-433, and miR-106a) were identified as useful for differentiating indolent and aggressive forms of PCa. | 27601638 |
| Squamous cell carcinoma of lung, Adenocarcinoma of lung (disorder), Primary malignant neoplasm | Epigenetic Alterations | We obtained epigenome-wide DNA methylation data from lung adenocarcinoma (LUAD) and lung squamous cell (LUSC) tissues in The Cancer Genome Atlas (TCGA). | 27602958 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNA-9 regulates the development of knee osteoarthritis through the NF-kappaB1 pathway in chondrocytes. | 27603333 |
| Degenerative polyarthritis | Epigenetic Alterations | It has been suggested that microRNA-9 (miR-9) is associated with the development of knee osteoarthritis (OA). | 27603333 |
| Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation occurs frequently in breast carcinogenesis. | 27604360 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | We assessed the suitability of FFPE breast cancer material for genome-wide DNA methylation assessment of tumour and ADJNT. | 27604360 |
| Breast Carcinoma | Epigenetic Alterations | Tools for translational epigenetic studies of breast cancer involving formalin-fixed paraffin-embedded (FFPE) human tissues have now been developed. | 27604360 |
| Carcinoma of lung | Epigenetic Alterations | Micro RNA-98 interferes with expression interleukin-10 in peripheral B cells of patients with lung cancer. | 27605397 |
| Atypical Reparative Cell | Epigenetic Alterations | The results provided a potential strategy of ARC management by manipulating epigenetic changes. | 27607418 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Importantly, the selectively enriched exosome microRNA, human miR-1246, was detected at significantly higher levels in exosomes isolated from PDX mouse plasma, indicating that tumor exosome microRNAs are released into the circulation and can serve as plasma biomarkers for breast cancer. | 27608715 |
| Breast Carcinoma | Epigenetic Alterations | Our results demonstrate that certain microRNA species, such as miR-21 and miR-1246, are selectively enriched in human breast cancer exosomes and significantly elevated in the plasma of patients with breast cancer. | 27608715 |
| Breast Carcinoma | Epigenetic Alterations | Plasma exosome microRNAs are indicative of breast cancer. | 27608715 |
| Breast Carcinoma | Epigenetic Alterations | microRNAs are promising candidate breast cancer biomarkers due to their cancer-specific expression profiles. | 27608715 |
| Breast Carcinoma | Epigenetic Alterations | However, efforts to develop circulating breast cancer biomarkers are challenged by the heterogeneity of microRNAs in the blood. | 27608715 |
| Breast Carcinoma | Epigenetic Alterations | To overcome this challenge, we aimed to develop a molecular profile of microRNAs specifically secreted from breast cancer cells. | 27608715 |
| Breast Carcinoma | Epigenetic Alterations | Cellular and exosome microRNAs from breast cancer cell lines were profiled by next-generation small RNA sequencing. | 27608715 |
| Breast Carcinoma | Epigenetic Alterations | Small RNA sequencing and qRT-PCR analysis showed that several microRNAs are selectively encapsulated or highly enriched in breast cancer exosomes. | 27608715 |
| Breast Carcinoma | Epigenetic Alterations | These findings indicate a potential new strategy to selectively analyze plasma breast cancer microRNAs indicative of the presence of breast cancer. | 27608715 |
| Primary malignant neoplasm | Epigenetic Alterations | Among these PARP genes, poly ADP-ribose polymerase family, member 15 (PARP15) is a candidate gene for cancer development due to its ability to regulate gene transcription and its reported association with apoptosis. | 27610459 |
| Primary malignant neoplasm | Epigenetic Alterations | They collected mRNA and microRNA expression profiles and gathered the corresponding clinical data of 73 BRCA patients with radiotherapy from The Cancer Genome Atlas (TCGA). | 27610468 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-126 inhibits tumor proliferation and angiogenesis of hepatocellular carcinoma by down-regulating EGFL7 expression. | 27611944 |
| Prostate Cancer Pathway, Neoplasms | Epigenetic Alterations | Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer. | 27611943 |
| CHOANAL ATRESIA, POSTERIOR, Metastasis | Epigenetic Alterations | We propose a novel, paradigm shifting hypothesis that this frequently deleted locus is also associated with a cluster of microRNA genes- miR-3622a/b- that are lost in PCa and play an important mechanistic role in progression and metastasis. | 27611943 |
| Prostate Cancer Pathway | Epigenetic Alterations | Considering the association of chr8p21 loss with poor prognosis, our findings are highly significant and support a novel concept that associates a long standing observation of frequent loss of a chromosomal region with a novel miRNA in prostate cancer. | 27611943 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-21 promotes TGF-b1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression. | 27611950 |
| Breast Carcinoma | Epigenetic Alterations | Correlation between the DNA methylation and gene expression of IGFBP5 in breast cancer. | 27612043 |
| Squamous cell carcinoma | Epigenetic Alterations | Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition. | 27613832 |
| Neoplasms | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have emerged recently as key regulators of tumor development and progression. | 27613832 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Esophageal squamous cell carcinoma (ESCC) is a fatal disease contributed by both genetic and epigenetic factors. | 27613842 |
| Stomach Carcinoma | Epigenetic Alterations | Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer. | 27614739 |
| Metastasis | Epigenetic Alterations | Decreased serum miRNA-206 expression was significantly associated with deep local invasion, positive lymph node metastasis, and advanced clinical stage. | 27614739 |
| Primary malignant neoplasm | Epigenetic Alterations | These results suggest that serum miRNA-206 might not only serve as a novel diagnostic biomarker for GC, but also predict cancer recurrence and patients prognosis. | 27614739 |
| Malignant Neoplasms | Epigenetic Alterations | Recent studies have demonstrated that microRNAs (miRNAs) can serve as useful biomarkers for human cancers. | 27614739 |
| Meningioma | Epigenetic Alterations | Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas. | 27614886 |
| Meningioma | Epigenetic Alterations | Tumor-related DNA methylation of the DLC1 isoform 1 alternative promoter was identified as being hypermethylated in meningiomas in genome-wide DNA methylation profiling. | 27614886 |
| Meningioma | Epigenetic Alterations | All histopathological subtypes of meningiomas showed similar and significant increase of DNA methylation levels. | 27614886 |
| Meningioma | Epigenetic Alterations | High DNA methylation was associated with lack of DLC1 protein expression in meningiomas as determined by immunohistochemistry. | 27614886 |
| Malignant neoplasm of breast | Epigenetic Alterations | Portraying breast cancers with long noncoding RNAs. | 27617288 |
| Primary malignant neoplasm | Epigenetic Alterations | Evidence is emerging that long noncoding RNAs (lncRNAs) may play a role in cancer development, but this role is not yet clear. | 27617288 |
| Malignant Neoplasms, Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have been proven to be important oncogenes and tumor suppressors in wide range of cancers, including renal cell carcinoma (RCC). | 27619681 |
| melanoma | Epigenetic Alterations | Our data illustrate another epigenetic mechanism activated by MS-275 at the post-transcriptional level in melanoma, in addition to its best-known effects at the transcriptional level. | 27620505 |
| Gammopathy | Epigenetic Alterations | Aberrant DNA methylation is considered a crucial mechanism in the pathogenesis of monoclonal gammopathies. | 27622827 |
| Primary malignant neoplasm | Epigenetic Alterations | Cancer initiation and progression has been linked to aberrant expression of the DNA methyltransferases (DNMT), the enzymes which establish and maintain DNA methylation patterns throughout the genome. | 27623253 |
| Vulvar Neoplasms | Epigenetic Alterations | These observations are consistent with the possibility that epigenetic changes contribute to vulvar neoplasia and DNMT3A over-expression may be useful in predicting local disease recurrence. | 27623253 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Currently, little is known about differences in miRNA expression between KIT/PDGFRA mutant and KIT/PDGFRA wild-type (WT)-SDH deficient gastrointestinal stromal tumors (GIST). | 27625077 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | This prompted us to perform an integrated multiple expression profile of miRNA and mRNA, constructing an original miRNA-mRNA regulatory network in KIT/PDGFRA WT-SDH deficient GIST patients. | 27625077 |
| Pancreatic carcinoma | Epigenetic Alterations | A panel of 13-miRNA signature as a potential biomarker for predicting survival in pancreatic cancer. | 27626307 |
| Bone necrosis | Epigenetic Alterations | TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt pathway in Steroid-Associated Osteonecrosis. | 27627619 |
| Coronary Artery Disease, Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | Interleukin-6 (IL-6) is implicated in the pathogenesis of coronary heart disease (CHD), and IL-6 expression has associated with reduced DNA methylation of its gene promoter. | 27627640 |
| Carcinoma | Epigenetic Alterations | TERT rs2736118 was associated with differences in miRNA expression between carcinoma and normal colonic mucosa for 75 miRNAs (FDR <0.05). | 27627813 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis. | 27628540 |
| HIV Antigens | Epigenetic Alterations | This discovery cohort data unveils cell type-specific DNA methylation patterns related to HIV-associated CI and provide an immunoepigenetic DNA methylation "signature" potentially useful for corroborating clinical assessments, informing pathogenic mechanisms, and revealing new therapeutic targets against CI. | 27629381 |
| Glioma | Epigenetic Alterations | The expression of miRNA-221 and miRNA-222 in gliomas patients and their prognosis. | 27629767 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The expression of miRNA-221 and miRNA-222 in human glioma cell line U87, U251, A172, LN229 and surgery resected glioma tissues were measured. | 27629767 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | 165 cases of glioma patients were recruited successfully; the expression of miRNA-221 and miRNA-222 in their resected tissues were measured. | 27629767 |
| Primary malignant neoplasm | Epigenetic Alterations | The expression of miRNA-221 and miRNA-222 in cancer tissues were obviously higher than control tissues (normal brain tissue) and control cell (gastric mucosal epithelial cell, GES) (p < 0.05). | 27629767 |
| Malignant Glioma | Epigenetic Alterations | The highly malignant glioma tissues expressed significantly higher miRNA-221 and miRNA-222 than low malignant glioma tissues. | 27629767 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Survival rate of glioma cells was significantly higher than GES cell after irradiation (p < 0.05); miRNA-221 in glioma cells. | 27629767 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The expressions of miRNA-221 and miRNA-222 in irritated glioma cells were positively correlated with the survival rate of glioma cells (r = 0.629, 0.712, both p < 0.01). | 27629767 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | For the 165 glioma patients, the expressions of miRNA-221 and miRNA-222 increased with the increasing of pathological grades (kh 2 = 42.85, p < 0.01); and their survival time decreased when miRNA-221 expression elevated (kh 2 = 57.12, p < 0.01). | 27629767 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MiRNA-221 and miRNA-222 express highly in human glioma cells and tissues. | 27629767 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Promoter DNA methylation of CDO1 gene and its clinical significance in esophageal squamous cell carcinoma. | 27629777 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Our investigation suggests that epigenetic silencing of PTCH is a mechanism contributing to CLL tumorigenesis. | 27630290 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Epigenetic regulators, including Jumonji domain 2 (JMJD2/KDM4) proteins are involved in post-translational modification of histone demethylation and have a major role in carcinogenesis of many solid tumors. | 27630312 |
| Malignant neoplasm of urinary bladder, Primary malignant neoplasm | Epigenetic Alterations | Abnormal expression of microRNAs (miRNAs) plays an important role in development of several cancer types, including bladder cancer (BCa). | 27631180 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Circulating long noncoding RNA GAS5 is a novel biomarker for the diagnosis of nonsmall cell lung cancer. | 27631209 |
| Neoplasms | Epigenetic Alterations | The recently discovered long noncoding RNAs have the potential to regulate many biological processes, which are aberrantly expressed in many tumor types. | 27631209 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | MiRNAs are master regulators of gene expression and several biological processes, and they are dysregulated in various cancers, where they play a vital role in either cancer progression or suppression. | 27631726 |
| Limited stage (cancer stage) | Epigenetic Alterations | The levels of three miRNAs (miR-22-3p, miR-642b-3p and miR-885-5p) and CA19-9 were significantly higher in PC patients, even those with early-stage disease (IB and IIB), than in healthy control. | 27631726 |
| Neoplasms | Epigenetic Alterations | Both miRNAs and CA19-9 were associated with tumor stage. | 27631726 |
| Clinical Coordinator | Epigenetic Alterations | The here identified miRNA markers, miR-122 and the miR-200 family members, could be of use in the development of a multi-marker blood test for CRC prognosis. | 27632639 |
| Malignant Neoplasms, Colorectal Cancer Pathway, Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNAs (miRNAs) have been proposed as minimally invasive prognostic markers for various types of cancers, including colorectal cancer (CRC), the third most diagnosed cancer worldwide. | 27632639 |
| Squamous cell carcinoma of vulva | Epigenetic Alterations | Long non-coding RNA expression profile in vulvar squamous cell carcinoma and its clinical significance. | 27633334 |
| Squamous cell carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | Regulation of TPD52 by antitumor microRNA-218 suppresses cancer cell migration and invasion in lung squamous cell carcinoma. | 27633630 |
| Carcinoma of lung, Aggressive behavior | Epigenetic Alterations | Aberrant microRNA (miRNA) expression has been shown to promote lung cancer development and aggressiveness. | 27633630 |
| Malignant Neoplasms | Epigenetic Alterations | Downregulation of microRNA-218 (miR-218) was frequently observed in our miRNA expression signatures of cancers, and previous studies have shown an antitumor function of miR-218 in several types of cancers. | 27633630 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA-187 is an independent prognostic factor in lung cancer and promotes lung cancer cell invasion via targeting of PTRF. | 27634346 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in the progression of different types of cancers giving new hope for cancer treatment. | 27634346 |
| Malignant tumor of colon | Epigenetic Alterations | Overexpression of Long Non-Coding RNA TUG1 Promotes Colon Cancer Progression. | 27634385 |
| Prostate Cancer Pathway | Epigenetic Alterations | Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer. | 27634912 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Here, we demonstrate that microRNA-4534 (miR-4534) is overexpressed in PCa and show that miR-4534 is hypermethylated in normal tissues and cell lines compared to PCa tissues/cells. | 27634912 |
| Carcinogenesis | Epigenetic Alterations | These results have important implications for identifying and defining the role of new PTEN regulators such as microRNAs in prostate tumorigenesis. | 27634912 |
| Malignant tumor of colon | Epigenetic Alterations | Additionally, we evaluated CTA expression in three colon cancer cell lines (CL-188, HTB-39, and HTB-37) after exposure to the DNA methylation-modifying drug 5-azacytidine. | 27635108 |
| ovarian neoplasm | Epigenetic Alterations | Using customized TaqMan low density miRNA arrays, we first screened expression levels of 48 miRNAs in sera from 18 epithelial ovarian cancer patients and 16 benign ovarian tumor patients. | 27636713 |
| Malignant - descriptor, ovarian neoplasm | Epigenetic Alterations | Array screening data showed that expression levels of serum miRNA-20a, miRNA-125b, miRNA-126, miRNA-355, and let-7c were significantly different between malignant and benign ovarian tumor patients. | 27636713 |
| ovarian neoplasm | Epigenetic Alterations | Subsequent real-time polymerase chain reaction results showed that serum miRNA-125b levels were significantly higher in epithelial ovarian cancer patients compared to benign controls. | 27636713 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | Moreover, serum miRNA-125b levels were significantly higher in ovarian cancer patients in early stages I and II, and in patients having no residual tumor following surgery, but were not associated with differentiation and histological types of ovarian cancer. | 27636713 |
| Carcinoma, Ovarian Epithelial | Epigenetic Alterations | miRNA-125b plays an important role in the pathogenesis and progression of epithelial ovarian cancer. | 27636713 |
| ovarian neoplasm | Epigenetic Alterations | Circulating miRNA-125b has the potential to become a novel biomarker for early diagnosis and prognosis prediction of epithelial ovarian cancer. | 27636713 |
| Alcoholic Liver Diseases | Epigenetic Alterations | Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. | 27639178 |
| Alcoholic Steatohepatitis | Epigenetic Alterations | Here, we tested the hypothesis that during early alcoholic steatohepatitis (ASH) development, hepatocytes (HCs) release EVs with an miRNA signature that can be measured in circulation. | 27639178 |
| Colorectal Neoplasms, Sessile Serrated Adenoma/Polyp | Epigenetic Alterations | Human sessile serrated adenomas and right-sided colorectal tumors with epigenetic loss of MutL homolog 1 (MLH1) had lost or had lower levels of HES1 than other colorectal tumor types or nontumor tissues. | 27639802 |
| Impaired cognition | Epigenetic Alterations | These results suggested that the DNA methylation of the SORL1 5-flanking region may significantly influence the manifestation of mild cognitive impairment in T2DM, and might be associated with its neurocognitive presentation. | 27641082 |
| Primary malignant neoplasm | Epigenetic Alterations | As a special form of noncoding RNAs, circular RNAs (circRNAs) played important roles in regulating cancer progression mainly by functioning as miRNA sponge. | 27642589 |
| Neuropathic pain, Feel Pain | Epigenetic Alterations | Deciphering miRNA-target interactions that influence inflammatory pathways in neuropathic pain may contribute to the discovery of new roads towards pain amelioration. | 27646435 |
| Neuropathic pain | Epigenetic Alterations | We demonstrate that microRNAs (miRNAs) are involved in the differentiation of Tregs in neuropathic pain. | 27646435 |
| Chicken anemia virus | Epigenetic Alterations | To date, there are no established noninvasive biomarkers available for prediction of CAV in transplanted patients.MicroRNAs (miRNAs) are highly conserved, small noncoding RNA molecules that negatively regulate gene expression. | 27653298 |
| Cardiovascular Diseases | Epigenetic Alterations | As they are detectable in peripheral blood, recent studies have suggested miRNAs as biomarkers for various cardiovascular diseases. | 27653298 |
| Chicken anemia virus | Epigenetic Alterations | Thus, we hypothesized that circulating miRNAs may serve as noninvasive biomarkers for CAV. | 27653298 |
| Antilymphocyte Serum | Epigenetic Alterations | The understanding of the mechanisms, either genetic or epigenetic, through which exogenous factors influence disease phenotype is of major importance towards a more focused approach to cure ALS. | 27656044 |
| Stage I Esophageal Squamous Cell Carcinoma AJCC v7 | Epigenetic Alterations | Overexpression of microRNA-1288 in oesophageal squamous cell carcinoma. | 27658568 |
| Colonic Polyps | Epigenetic Alterations | MicroRNA Signatures of Colonic Polyps on Screening and Histology. | 27658891 |
| Colorectal Cancer Pathway, Primary malignant neoplasm, Adenoma | Epigenetic Alterations | Colorectal cancer and adenoma adjacent to cancer exhibit distinct microRNA (miRNA) alterations in an apparent mucosa-to-adenocarcinoma sequence. | 27658891 |
| Adenoma | Epigenetic Alterations | Our data support the presence of colorectal cancer-associated miRNA alterations in screen-detected adenomas that may be useful for risk stratification for surveillance interval planning. | 27658891 |
| Malignant Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNAs (miRNAs) are a class of small noncoding RNAs with pivotal roles in cellular and molecular processes related to different malignancies including CLL. | 27659777 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Circulating microRNA-192 as a diagnostic biomarker in human chronic lymphocytic leukemia. | 27659777 |
| Coronary Artery Disease | Epigenetic Alterations | Circulating MicroRNAs as Novel Diagnostic Biomarkers for Very Early-onset (<=40 years) Coronary Artery Disease. | 27660218 |
| Colonic adenomas, Adenocarcinoma of large intestine | Epigenetic Alterations | SEPT9 and SHOX2 DNA methylation status and its utility in the diagnosis of colonic adenomas and colorectal adenocarcinomas. | 27660666 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28. | 27661126 |
| Clinical Coordinator, Metastasis | Epigenetic Alterations | MicroRNAs (miRNAs or miRs) have been demonstrated to play crucial roles in the development, metastasis and drug resistance of CRC. | 27661126 |
| Heart failure | Epigenetic Alterations | Circulating microRNAs (miRNAs) emerge as potential heart failure biomarkers. | 27661412 |
| Urinary tract infection | Epigenetic Alterations | In conclusion, the measurement of circulating microRNAs in plasma from patients with renal transplants distinguishes TCMR and urinary tract infection from stable graft function. | 27663089 |
| ovarian neoplasm | Epigenetic Alterations | Using an ovarian cancer cell line model, we demonstrate that functional mismatch repair increases the frequency of platinum-induced methylation.Conclusions: DNA methylation in blood at relapse following chemotherapy, and not at presentation, is informative regarding survival of patients with ovarian cancer. | 27663594 |
| Neoplasms | Epigenetic Alterations | DNA methylation in blood following chemotherapy could provide a noninvasive means of monitoring patients epigenetic responses to treatment without requiring a tumor biopsy. | 27663594 |
| Arteriosclerosis, Coronary Artery Disease, Acute myocardial infarction | Epigenetic Alterations | MicroRNAs (miRNAs), small non-coding RNAs, have been implicated as regulators of all mediators of atherosclerosis, and some reports have suggested increased levels in coronary artery disease (CAD) and acute myocardial infarction (AMI). | 27665403 |
| Coronary Artery Disease | Epigenetic Alterations | miRNA-93-5p and other miRNAs as predictors of coronary artery disease and STEMI. | 27665403 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | MicroRNAs modulate the expression of the SOX18 transcript in lung squamous cell carcinoma. | 27666488 |
| Carcinoma of lung, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Because of the fact that microRNAs (miRNAs) play important roles in the initiation and progression of lung cancer, the main aim of this study was to identify the miRNAs that interact with the SOX18 transcript in NSCLC cases. | 27666488 |
| Primary malignant neoplasm | Epigenetic Alterations | In conclusion, miRNAs interact with the mRNA of the SOX18 gene, but the mechanism by which they could be inhibited in cancer cells requires further examination. | 27666488 |
| Primary malignant neoplasm, Liver carcinoma | Epigenetic Alterations | MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma. | 27666683 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | In hepatocellular carcinoma (HCC), the master hypoxia-induced microRNA (miRNA) miR-210 is upregulated in HCC and participates in HCC progression, but its roles in hypoxia-induced HCC angiogenesis are still unknown. | 27666683 |
| ovarian neoplasm | Epigenetic Alterations | Long non-coding RNAs, ASAP1-IT1, FAM215A, and LINC00472, in epithelial ovarian cancer. | 27667152 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) are a class of non-protein coding transcripts that has gained significant attention lately due to their important biological actions and potential involvement in cancer. | 27667152 |
| Breast Cancer Cell | Epigenetic Alterations | MicroRNA biosynthesis genes can affect the regulatory effect of global microRNAs to target mRNA and hence influence the genesis and development of human cancer. | 27669275 |
| Rheumatoid Arthritis | Epigenetic Alterations | MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. | 27671860 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The role of miRNA-21 and epithelial mesenchymal transition (EMT) process in colorectal cancer. | 27672217 |
| Prostate Cancer Pathway | Epigenetic Alterations | microRNA-372 Suppresses Migration and Invasion by Targeting p65 in Human Prostate Cancer Cells. | 27673408 |
| Initiation, CHOANAL ATRESIA, POSTERIOR, Metastasis | Epigenetic Alterations | microRNAs (miRNAs) play an important role in cancer initiation, progression, and metastasis, and their roles in PCa are becoming more apparent. | 27673408 |
| Degenerative polyarthritis | Epigenetic Alterations | MiR-98 expression is reduced in the cartilage cells of OA patients and the overexpression of miR-98 inhibits cartilage cell apoptosis, while inhibition of microRNA-98 leads to cartilage cell apoptosis. | 27676099 |
| Primary malignant neoplasm | Epigenetic Alterations | Genetic polymorphisms in the 3 untranslated region (UTR) targeted by miRNAs can affect the regulation of target genes and individual cancer risk. | 27677255 |
| cervical cancer, Carcinoma, Ovarian Epithelial | Epigenetic Alterations | Previously, over-expression of the long noncoding RNA (lncRNA) HOTAIR has been found to be associated with the invasive and metastatic capacities of several epithelial cancers, including cervical cancer (CaCx). | 27683269 |
| Lewy Bodies, Dementia | Epigenetic Alterations | DNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies. | 27685250 |
| Lewy Body Disease | Epigenetic Alterations | No correlation was observed between SCNA mRNA expression levels and blood DNA methylation rates in either DLB or healthy controls. | 27685250 |
| Lewy Body Disease | Epigenetic Alterations | Epigenetic changes at the synuclein alpha ( SNCA ) gene may be involved in DLB pathogenesis. | 27685250 |
| Axonal degeneration | Epigenetic Alterations | The mutation is associated with several transcriptional changes, including a significant upregulation of another E3 ubiquitin-protein ligase, NEDD4L, and of TNFRSF21, a key regulator of axonal degeneration. | 27686364 |
| Primary malignant neoplasm | Epigenetic Alterations | In order to contribute to the elucidation of the role of DNA methylation changes in acquisition of a multidrug resistant (MDR) phenotype, we also analyzed the promoter methylation patterns in drug-resistant sublines of the cancer cell lines GLC-4, SW1573, KB-3-1 and HL-60. | 27689338 |
| Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | As the promoter region and the entire transcript are embedded in a CpG island, we postulated that BM742401 is a tumor suppressor lncRNA inactivated by DNA methylation in chronic lymphocytic leukemia (CLL). | 27689399 |
| Neoplasms, Chronic Lymphocytic Leukemia | Epigenetic Alterations | Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia. | 27689399 |
| Pancreatic carcinoma | Epigenetic Alterations | Long noncoding RNA uc.345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression. | 27689400 |
| Disease | Epigenetic Alterations | Increasing evidence points to an important functional or regulatory role of long noncoding RNA in cellular processes as well as cancer diseases resulted from the aberrant lncRNA expression. | 27689400 |
| Degenerative polyarthritis | Epigenetic Alterations | Therefore, premature epigenetic aging according to DNA methylation changes was specific of OA cartilage, adding further evidence and insight on premature aging of cartilage as a component of OA pathogenesis that reflects damage and vulnerability. | 27689435 |
| Degenerative polyarthritis | Epigenetic Alterations | Specific premature epigenetic aging of cartilage in osteoarthritis. | 27689435 |
| Degenerative polyarthritis | Epigenetic Alterations | By contrast, no difference in epigenetic aging was observed in bone (0.04 years; 95% CI = -1.8 to 1.9, P = 0.3) and in blood (-0.6 years; 95% CI = -1.5 to 0.3, P = 0.2) between OA patients and controls. | 27689435 |
| Epilepsy | Epigenetic Alterations | Expression of microRNA-129-2-3p and microRNA-935 in plasma and brain tissue of human refractory epilepsy. | 27689807 |
| melanoma, Neoplasms | Epigenetic Alterations | In addition, RAB22A was found to be a target of miR-203, a tumor suppressive miRNA in melanoma. | 27690221 |
| Infertility | Epigenetic Alterations | The influence of aberrant sperm DNA methylation on the reproductive capacity of couples has been postulated as a cause of infertility. | 27692602 |
| Metastasis, Neoplasms, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Tumor Specific Epigenetic Silencing of Corticotropin Releasing Hormone -Binding Protein in Renal Cell Carcinoma: Association of Hypermethylation and Metastasis. | 27695045 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Here we investigated hypermethylation and epigenetic silencing of the CRH-Binding Protein (CRHBP) gene in clear cell renal cell cancer (ccRCC). | 27695045 |
| Malignant neoplasm of kidney, Aggressive behavior, Neoplasms | Epigenetic Alterations | We describe for the first time tumor specific epigenetic silencing of CRHBP and statistical association with aggressive tumors thus suggesting the CRH system to contribute to the development of kidney cancer. | 27695045 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are regulatory molecules proven to be accurate biomarkers in cancer. | 27699216 |
| Cell of Claudius | Epigenetic Alterations | Here, we identified miRNAs predictive of progressive disease under TKI treatment through deep sequencing of 74 metastatic clear cell RCC cases uniformly treated with these drugs. | 27699216 |
| selenium | Epigenetic Alterations | Insomnia symptoms were related to advanced epigenetic age (b +- SE = 1.02 +- 0.37, p = .005) after adjustments for covariates. | 27702440 |
| Sleeplessness | Epigenetic Alterations | Symptoms of insomnia were associated with increased epigenetic age of blood tissue and were associated with higher counts of late differentiated CD8+ T cells. | 27702440 |
| Senile cataract | Epigenetic Alterations | Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. | 27703255 |
| Senile cataract | Epigenetic Alterations | Histone acetylation plays key roles in gene expression, but its effects on superoxide dismutase 1 (SOD1) expression in senile cataract remains unknown. | 27703255 |
| Senile cataract | Epigenetic Alterations | Decreased histone acetylation at the SOD1 promoter is associated with declined SOD1 expression in senile cataracts. | 27703255 |
| Senile cataract | Epigenetic Alterations | Histone acetylation plays an essential role in the regulation of SOD1 expression and in the pathogenesis of senile cataracts. | 27703255 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Epigenetic Alterations | Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling. | 27705804 |
| Neoplasms | Epigenetic Alterations | Aberrant DNA methylation patterns in malignant cells allow insight into tumor evolution and development and can be used for disease classification. | 27705804 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Epigenetic Alterations | Here, we describe the genome-wide DNA methylation signatures of NPM-ALK-positive (ALK+) and NPM-ALK-negative (ALK-) anaplastic large-cell lymphoma (ALCL). | 27705804 |
| Ki-1+ Anaplastic Large Cell Lymphoma, Neoplasms | Epigenetic Alterations | We find that ALK+ and ALK- ALCL share common DNA methylation changes for genes involved in T cell differentiation and immune response, including TCR and CTLA-4, without an ALK-specific impact on tumor DNA methylation in gene promoters. | 27705804 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Epigenetic Alterations | Furthermore, we uncover a close relationship between global ALCL DNA methylation patterns and those in distinct thymic developmental stages and observe tumor-specific DNA hypomethylation in regulatory regions that are enriched for conserved transcription factor binding motifs such as AP1. | 27705804 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Epigenetic Alterations | Our results indicate similarity between ALCL tumor cells and thymic T cell subsets and a direct relationship between ALCL oncogenic signaling and DNA methylation through transcription factor induction and occupancy. | 27705804 |
| Borrelia | Epigenetic Alterations | The three Borrelia strains tested exhibited similar transcriptional profiles, and no species-specific fingerprint of transcriptional changes in fibroblasts was observed. | 27706261 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Genetic and epigenetic factors contribute to PCa development and progression. | 27706591 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) play an important role in carcinogenesis by regulating oncogenes and tumor suppressors. | 27706712 |
| palladium | Epigenetic Alterations | We hypothesized that epigenetic variations could be associated with PD and evaluated the DNA methylation pattern in PD patients compared to brothers or twins without PD. | 27709425 |
| palladium | Epigenetic Alterations | Our findings suggest that a distinct level of PD susceptibility stems from individual, epigenetic modifications of specific genes. | 27709425 |
| Malignant Neoplasms | Epigenetic Alterations | Micro-RNAs (miRNAs) play roles in the pathogenesis of several malignancies by regulating gene expression and have been recently identified as stable entities in serum. | 27709652 |
| Alzheimers Disease", Parkinson Disease | Epigenetic Alterations | Altered DNA methylation of the microtubule-associated protein tau gene correlates with the expression changes in Alzheimers disease and Parkinsons disease brains. | 27709663 |
| Tauopathies | Epigenetic Alterations | This exploratory study suggests that regions other than the constitutive promoter may be involved in microtubule-associated protein tau gene regulation in tauopathies and that intron 0 hypomethylation may be a specific epigenetic signature of PSP. | 27709663 |
| Schizophrenia | Epigenetic Alterations | DNA methylation profiles were generated for CpG sites proximal to Val66Met, within BDNF promoter I and exon V for prefrontal cortex samples from 25 schizophrenia and 25 control subjects. | 27712141 |
| Schizophrenia | Epigenetic Alterations | DNA methylation of one CpG site had a marginally significant positive correlation with mRNA expression in schizophrenia subjects. | 27712141 |
| Schizophrenia | Epigenetic Alterations | A larger age-matched cohort with comprehensive clinical history is required to accurately identify the effects of genotype, mRNA expression and DNA methylation on schizophrenia risk. | 27712141 |
| Pancreatic carcinoma | Epigenetic Alterations | New combined microRNA and protein plasmatic biomarker panel for pancreatic cancer. | 27713117 |
| Psoriasis | Epigenetic Alterations | Increasing evidences indicate that the abnormal DNA methylation is involved in the pathogenesis of psoriasis. | 27713139 |
| Breast Carcinoma | Epigenetic Alterations | Breast cancer represents a heterogenous disease that can be divided into breast cancer subtypes due to different subsets of genetic and epigenetic abnormalities. | 27713152 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Protein-coding genes combined with long non-coding RNAs predict prognosis in esophageal squamous cell carcinoma patients as a novel clinical multi-dimensional signature. | 27714034 |
| Malignant Neoplasms | Epigenetic Alterations | Both protein-coding genes (PCGs) and long non-coding RNAs (lncRNAs) have been shown to play an important role in the development of malignant tumors. | 27714034 |
| Rheumatoid Arthritis | Epigenetic Alterations | Long noncoding RNA expression profile in fibroblast-like synoviocytes from patients with rheumatoid arthritis. | 27716329 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have recently received wide attention as key molecules that mediate a variety of physiological and pathological processes by regulating gene expression; however, knowledge of lncRNAs in rheumatoid arthritis (RA) is limited. | 27716329 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | PITX2 and PANCR DNA methylation predicts overall survival in patients with head and neck squamous cell carcinoma. | 27716615 |
| Parkinson Disease | Epigenetic Alterations | Parkinsons disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus. | 27717584 |
| CDISC Integrated Basic Data Structure Dataset | Epigenetic Alterations | Recently, microRNAs (miRNAs) have been shown to be involved in the development of IBDs. | 27718165 |
| S100A4 protein, human | Epigenetic Alterations | MicroRNA-375 as a biomarker for malignant transformation in oral lesions. | 27720656 |
| Cardiovascular Diseases | Epigenetic Alterations | Optimized Collection Protocol for Plasma MicroRNA Measurement in Patients with Cardiovascular Disease. | 27725938 |
| Stomach Carcinoma | Epigenetic Alterations | A Tumor-Specific Prognostic Long Non-Coding RNA Signature in Gastric Cancer. | 27727196 |
| Primary malignant neoplasm | Epigenetic Alterations | We detected promoter methylation using quantitative methylation-specific real-time PCR and methylation-on-beads for cancer-specific genes (SOX17, TAC1, HOXA7, CDO1, HOXA9, and ZFP42).Results: DNA methylation was detected in plasma and sputum more frequently in people with cancer compared with controls (P < 0.001) for five of six genes. | 27729459 |
| leukemia | Epigenetic Alterations | In leukemias, however, both leukemic and nonleukemic cells compose circulating miRNA expression profile of peripheral blood. | 27730344 |
| Primary malignant neoplasm | Epigenetic Alterations | Expression of microRNAs is altered in cancer. | 27730344 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Alterations of expression observed in CLL patients involved miRNAs associated both with B and T lymphocyte differentiation and activation. | 27730344 |
| Metabolic Diseases, Cardiovascular Diseases | Epigenetic Alterations | Epigenetic alterations have been linked to the presence of Cr, and microRNA (miRNA) expression has been implicated in the pathogenesis of metabolic diseases and cardiovascular diseases (CVDs). | 27731332 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Diagnostic and prognostic value of plasma microRNA-195 in patients with non-small cell lung cancer. | 27733164 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Plasma miRNA-195 was downregulated in NSCLC patients compared with healthy controls (P < 0.001). | 27733164 |
| Metastasis | Epigenetic Alterations | Decreased plasma miRNA-195 expression was significantly associated with lymph node metastasis and advanced clinical stage. | 27733164 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | ROC curve analysis showed that plasma miRNA-195 was a useful marker for NSCLC diagnosis. | 27733164 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Multivariate Cox regression analysis confirmed low plasma miRNA-195 expression as an independent unfavorable prognostic factor for NSCLC patients. | 27733164 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These findings indicate that plasma miRNA-195 might serve as a promising biomarker for the early detection and prognosis evaluation of NSCLC. | 27733164 |
| Malignant Neoplasms | Epigenetic Alterations | Recently, circulating microRNAs (miRNAs) have been reported to be stably detectable in plasma/serum and to function as potent biomarkers in various cancers. | 27733164 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Prognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer. | 27737015 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | MiRNA-205 seems to be one of the key regulators of gene expression in endometrial cancer. | 27737015 |
| Malignant Neoplasms, Myometrial Invasion, Neoplasms | Epigenetic Alterations | Higher levels of miRNA-205 expression were observed in tumours with less than half of myometrial invasion and non-advanced cancers. | 27737015 |
| Initiation | Epigenetic Alterations | Altered expression of miRNAs may be associated with cancer initiation, progression and metastatic capabilities. | 27737015 |
| Neoplasms | Epigenetic Alterations | Our results identify novel mechanisms by which epigenetic regulators can affect tumor progression and suggest that prosenescence therapies could be employed against SWI/SNF-mutated cancers. | 27737960 |
| Neoplasms | Epigenetic Alterations | Mutational-driven comparison with other tumor types showed that UM is very similar to pediatric tumors, characterized by very few somatic insults and, possibly, important epigenetic changes. | 27745836 |
| Asthma Pathway, Allergic | Epigenetic Alterations | We sought to identify DNA methylation and gene expression changes associated with childhood allergic persistent asthma. | 27745942 |
| Allergic asthma | Epigenetic Alterations | We compared genomic DNA methylation patterns and gene expression in African American children with persistent atopic asthma (n = 36) versus healthy control subjects (n = 36). | 27745942 |
| Allergic asthma | Epigenetic Alterations | Given the strong environmental influence on both epigenetic marks and allergic asthma in children, the epigenetic alterations in respiratory epithelia might provide insight into allergic asthma. | 27745942 |
| Asthma Pathway, Atopy | Epigenetic Alterations | Genes differentially methylated included those with established roles in asthma and atopy and genes related to extracellular matrix, immunity, cell adhesion, epigenetic regulation, and airflow obstruction. | 27745942 |
| Allergic asthma | Epigenetic Alterations | Epigenetic marks in respiratory epithelia are associated with allergic asthma and gene expression changes in inner-city children. | 27745942 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | Previous studies have suggested that long non-coding RNAs (lncRNAs) may be key regulators of tumor development and progression in HCC. | 27748842 |
| Childhood Leukemia | Epigenetic Alterations | It may be involved in the development of leukemia by mediating methylation of DNA and histones. | 27748863 |
| Malignant Neoplasms | Epigenetic Alterations | HOX antisense intergenic RNA (HOTAIR), a long non-coding RNA, plays an important role in the development of many types of cancers. | 27748863 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2. | 27748890 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-455 (miR-455) has been considered as a novel cancer-related miRNA and dysregulated expression frequently occurs in various human types of cancer. | 27748890 |
| cervical cancer | Epigenetic Alterations | Recent research has addressed the role of microRNAs in cervical cancer. | 27748903 |
| Mesothelioma | Epigenetic Alterations | This suggests that besides the exposure to asbestos other currently unknown genetic or epigenetic factors may be responsible for the high incidence of mesothelioma in BAP1-unmutated families. | 27751355 |
| Epithelioma | Epigenetic Alterations | We analysed whether the specific composition of microRNAs (miRNAs) and proteins of extracellular vesicles (EVs) that urothelial tumour cells of bladder mucosa release into the urine, could reflect their pathologic condition. | 27751843 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Using a microarray platform containing probes for 851 human miRNAs we found 26 deregulated miRNAs in high-grade bladder cancer urine EVs, from which 23 were downregulated and 3 upregulated. | 27751843 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Expression of miRNA-630 in bladder urothelial carcinoma and its clinical significance. | 27752905 |
| Malignant Neoplasms | Epigenetic Alterations | Many studies informed that microRNAs (miRNAs) could function as diagnostic and prognostic indicators in several cancers. | 27752905 |
| Ovarian Diseases | Epigenetic Alterations | Circulating miR-373, miR-200a, miR-200b and miR-200c were quantified in a cohort of 60 EOC patients, 20 patients with benign ovarian diseases and 32 healthy women using quantitative TaqMan MicroRNA assays. | 27753009 |
| Neoplasms | Epigenetic Alterations | In conclusion, the increased serum levels of this microRNA panel have diagnostic value for distinguishing healthy controls and benign tumors from EOC. | 27753009 |
| Federation of Gynecology and Obstetrics | Epigenetic Alterations | Elevated levels of these cell-free microRNAs could be detected in FIGO I-II and FIGO III-IV stages, grading G1-2 and G3 and lymph node-negative and -positive EOC. | 27753009 |
| Colorectal Cancer Pathway | Epigenetic Alterations | 485 blood-derived miRNAs were profiled in serum sample pools of both colorectal cancer and healthy control. | 27759076 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Seven candidate miRNAs chosen from profiling results as well as three previous reported reference miRNAs were validated using qPCR in 30 colorectal cancer patients and 30 healthy individuals, and thereafter analyzed by statistical algorithms BestKeeper, geNorm and NormFinder. | 27759076 |
| Colorectal Cancer Pathway | Epigenetic Alterations | More interestingly, the three miRNAs validated from 485 miRNAs are derived from a single primary transcript, indicting the cluster may be highly conserved in colorectal cancer. | 27759076 |
| Adenoma of large intestine | Epigenetic Alterations | Although there is a growing interest in developing circulating microRNA (miRNA) as noninvasive diagnostic biomarkers for the detection of high-risk colorectal adenomas and early-stage CRCs, but the comparative diagnostic significance of serum vs. exosomal miRNAs remains unexplored. | 27760147 |
| Adenoma of large intestine | Epigenetic Alterations | Diagnostic Potential of Cell-Free and Exosomal MicroRNAs in the Identification of Patients with High-Risk Colorectal Adenomas. | 27760147 |
| Adenoma of large intestine | Epigenetic Alterations | We observed that the expression of four miRNAs, miR-21, miR-29a, miR-92a, and miR-135b, was significantly higher in colorectal adenomas vs. normal colonic mucosa. | 27760147 |
| Adenomatous Polyps | Epigenetic Alterations | Compared to exosomal miRNAs, serum levels of miR-21, miR-29a and miR-92a are superior diagnostic biomarkers in patients with high-risk adenomatous polyps. | 27760147 |
| prostatitis | Epigenetic Alterations | Chronic Prostatitis Affects Male Reproductive Health and Is Associated with Systemic and Local Epigenetic Inactivation of C-X-C Motif Chemokine 12 Receptor C-X-C Chemokine Receptor Type 4. | 27760433 |
| Metastasis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-574-5p promotes metastasis of non-small cell lung cancer by targeting PTPRU. | 27761023 |
| Malignant Neoplasms, Behavior | Epigenetic Alterations | Dysregulation of microRNAs (miRNAs) has been associated with malignant behavior in a variety of cancers. | 27761023 |
| Hematologic Neoplasms | Epigenetic Alterations | MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report. | 27761889 |
| Hematologic Neoplasms | Epigenetic Alterations | MicroRNA-155 (miR155), a non-coding transcript of the B-cell integration cluster (BIC) gene, has been reported to play a critical role in the pathogenesis of several types of hematologic malignancies (HMs) in which high miR155 levels have been found. | 27761889 |
| Arteriosclerosis | Epigenetic Alterations | Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo. | 27764724 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition. | 27764771 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-7 inhibits cell proliferation, migration and invasion in human non-small cell lung cancer cells by targeting FAK through ERK/MAPK signaling pathway. | 27764812 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma. | 27765924 |
| Aggressive behavior, Primary malignant neoplasm | Epigenetic Alterations | Expression levels of miR-145-5p and miR-145-3p were markedly reduced in cancer tissues, and ectopic expression of these miRNAs inhibited cancer cell aggressiveness, suggesting that both miR-145-3p as well as miR-145-5p acted as antitumor miRNAs. | 27765924 |
| Stomach Carcinoma | Epigenetic Alterations | microRNA analysis of gastric cancer patients from Saudi Arabian population. | 27766962 |
| Primary malignant neoplasm | Epigenetic Alterations | The role of small non-coding microRNAs (miRNAs) in several types of cancer has been evident. | 27766962 |
| Primary malignant neoplasm | Epigenetic Alterations | Only 33 miRNAs had significant expression in early and late-stage cancer tissues. | 27766962 |
| MIR200C gene, MIR27B gene | Epigenetic Alterations | After candidate miRNAs were selected, RT-qPCR further confirmed that four miRNAs (hsa-miR-200c-3p, hsa-miR-3613, hsa-miR-27b-3p, hsa-miR-4668-5p) were significantly aberrant in GC tissues compared to the normal gastric tissues. | 27766962 |
| Stomach Carcinoma | Epigenetic Alterations | In this study we provide miRNAs profile of GC where many miRNAs showed aberrant expression from normal tissues, suggesting their involvement in the development and progression of gastric cancer. | 27766962 |
| Fuchs Endothelial Dystrophy, Corneal dystrophy | Epigenetic Alterations | Interestingly, upregulated miRNAs in the 378 family in corneal endothelium dramatically decreased in the tissues with lower ECD with advanced gutatta, providing new insight on the pathogenesis of Fuchs endothelial corneal dystrophy. | 27768788 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | MicroRNA signatures of BAL cells and alveolar macrophages are currently lacking in IPF. | 27769060 |
| Idiopathic Pulmonary Fibrosis, Fibrosis Assessment | Epigenetic Alterations | We thus focused on microRNAs previously associated with fibrosis (miR-29a, miR-29b, miR-29c, let-7d, and miR-21) and rapid IPF progression (miR-185, miR-210, miR-302c-3p miR-376c and miR-423-5p). | 27769060 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. | 27769862 |
| Adenoma | Epigenetic Alterations | Follow-up of these epigenetic markers is suggested to further evaluate their utility for adenoma screening or surveillance. | 27771773 |
| Colorectal Carcinoma Metastatic in the Lung | Epigenetic Alterations | A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. | 27775664 |
| Secondary malignant neoplasm of lung | Epigenetic Alterations | Colorectal liver and lung metastases have a unique miRNA expression profile. | 27775664 |
| Secondary malignant neoplasm of liver, Neoplasms | Epigenetic Alterations | miRNA expression in the host tissue of colorectal liver metastases seems to be able to influence tumor progression and survival. | 27775664 |
| Neoplasms | Epigenetic Alterations | miRNAs with a significant change >2-fold between the tumor, tumor stroma, and host tissue were analyzed in all samples using RT-qPCR (11 miRNAs) and correlated with the clinical data. | 27775664 |
| Neoplasms | Epigenetic Alterations | We found a differential expression of several miRNAs between the tumor, the tumor-associated stroma, and the host tissue compartment. | 27775664 |
| Carcinoma of lung | Epigenetic Alterations | Integrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection. | 27777637 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Abnormal microRNA (miRNA) expressions and promoter methylation of genes detected in sputum may provide biomarkers for non-small lung cancer (NSCLC). | 27777637 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The panel of 3 miRNA biomarkers has 81.5 % sensitivity and 85.9 % specificity; the panel of 3 methylation biomarkers displays 82.9 % sensitivity and 76.4 % specificity for NSCLC detection. | 27777637 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | We analyze expression of 3 miRNAs (miR-21, miR-31, and miR-210) and methylation of 3 genes (RASSF1A, PRDM14, and 3OST2), which were previously identified as potential biomarkers for NSCLC, in sputum of a set of 117 stage I NSCLC patients and 174 cancer-free smokers. | 27777637 |
| Primary malignant neoplasm, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Regulation of MMP13 by antitumor microRNA-375 markedly inhibits cancer cell migration and invasion in esophageal squamous cell carcinoma. | 27779648 |
| Malignant Neoplasms | Epigenetic Alterations | Accordingly, we have sequentially identified microRNA (miRNA)-mediated metastatic pathways in several cancers. | 27779648 |
| Malignant Neoplasms, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Our past studies of miRNA expression signatures have shown that microRNA-375 (miR-375) is frequently reduced in several types of cancers, including ESCC. | 27779648 |
| Squamous cell carcinoma of esophagus, Primary malignant neoplasm | Epigenetic Alterations | The expression of miR-375 was downregulated in ESCC tissues, and ectopic expression of this miRNA markedly inhibited cancer cell migration and invasion, suggesting that miR-375 acted as an antimetastatic miRNA in ESCC cells. | 27779648 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Our strategies for miRNA target searching demonstrated that matrix metalloproteinase 13 (MMP13) was directly regulated by miR-375 in ESCC cells. | 27779648 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are a class of small, well-conserved, non-coding RNAs that are increasingly identified as diagnostic and prognostic biomarkers in a number of cancers. | 27779679 |
| Neoplasms | Epigenetic Alterations | Overexpression of miRNA-148a and knockdown of INO80 acted synergistically to decrease the expression of stem cell marker genes as well as to attenuate stem cell-specific properties including the ability to form tumors. | 27779717 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) have recently been found as an important class of cellular regulators of ATC carcinogenesis. | 27779717 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Association of cigarette smoking and microRNA expression in rectal cancer: Insight into tumor phenotype. | 27780077 |
| Clinical Coordinator, Colorectal Carcinoma | Epigenetic Alterations | Our sample consisted of 1447 CRC cases that had normal colorectal mucosa and carcinoma miRNA data and lifestyle data. | 27780077 |
| Neoplasms | Epigenetic Alterations | Our results suggest that cigarette smoking can alter miRNA expression and, given associations with CIMP high and MSI tumor molecular phenotype, it is possible that smoking influences tumor phenotype through altered miRNA expression. | 27780077 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Of the 306 unique miRNAs associated with cigarette smoking, 41 were inversely associated and 200 were directly associated with CIMP high or MSI tumor molecular phenotype for either colon or rectal cancer. | 27780077 |
| Breast Carcinoma, Aggressive behavior | Epigenetic Alterations | The long non-coding RNA 91H increases aggressive phenotype of breast cancer cells and up-regulates H19/IGF2 expression through epigenetic modifications. | 27780718 |
| Breast Carcinoma | Epigenetic Alterations | Taken together, overexpression of 91H in breast cancer and 91H-induced epigenetic modifications on H19/IGF2 locus suggest that 91H may play essential role in breast cancer development. | 27780718 |
| Decompensated cirrhosis of liver | Epigenetic Alterations | Decompensated cirrhosis is associated to extensive post-transcriptional changes of human albumin (HA). | 27782157 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Aberrant DNA methylation frequently occurs in malignant tumors but it scarcely occurs in benign tumors. | 27788211 |
| Neoplasms | Epigenetic Alterations | Differentially expressed mature miRNAs were identified between patients with or without tumor recurrence. | 27788488 |
| Pathologic mineralization, Aortic valve disorder | Epigenetic Alterations | Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1. | 27789555 |
| Aortic valve disorder | Epigenetic Alterations | Multidimensional genomic profiling was performed in human aortic valves to document the expression of lncRNAs and the DNA methylation pattern in calcific aortic valve disease. | 27789555 |
| Aortic valve disorder | Epigenetic Alterations | These findings indicate that a dysregulation of DNA methylation in the promoter of H19 during calcific aortic valve disease is associated with a higher expression of this lncRNA, which promotes an osteogenic program by interfering with the expression of NOTCH1. | 27789555 |
| Breast Carcinoma | Epigenetic Alterations | miRNAs are noncoding RNAs with abnormal expression in breast cancer; their expression in high-risk benign breast tissue may relate to breast cancer risk. | 27789587 |
| Neoplasms | Epigenetic Alterations | Seven miRNAs were differentially expressed in tumors and CUBs versus reduction mammoplasty samples. | 27789587 |
| Neoplasms | Epigenetic Alterations | Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. | 27791400 |
| Neoplasms | Epigenetic Alterations | In all, miR-203a and miR-203b may function as tumor suppressive miRNAs, and reactivation of miR-203a may have therapeutic potential and may be used as prognostic marker for GCA patients. | 27791400 |
| Malignant neoplasm of stomach stage IV | Epigenetic Alterations | MiRNA-3978 regulates peritoneal gastric cancer metastasis by targeting legumain. | 27793040 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic modification and dysregulation affecting the HIC1/SIRT1 axis is potentially important for the development of malignancies. | 27793057 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Dysregulation of miRNA expression may be used as a biomarker for specific tumours because it may contribute to development of cancer. | 27797225 |
| Breast Carcinoma | Epigenetic Alterations | Circulating miRNA profiles have been highlighted for their potential as predictive markers in heterogeneous diseases such as breast cancer. | 27797225 |
| Adenocarcinoma | Epigenetic Alterations | DNA Methylation of PITX2 and PANCR Is Prognostic for Overall Survival in Patients with Resected Adenocarcinomas of the Biliary Tract. | 27798672 |
| Metastatic Unresectable Carcinoma | Epigenetic Alterations | Prognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer. | 27798874 |
| Neoplasms | Epigenetic Alterations | MicroRNA (miR)-21 is overexpressed in most solid tumors and a high expression of miR-21 in tumor tissue is associated with a poor clinical outcome. | 27798874 |
| Autoimmune thrombocytopenia | Epigenetic Alterations | The aberrant expression of microRNAs and correlations with T cell subsets in patients with immune thrombocytopenia. | 27802180 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Serum microRNA-15a level acts as a potential diagnostic and prognostic biomarker for human esophageal squamous cell carcinoma. | 27802201 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients. | 27803053 |
| Primary malignant neoplasm | Epigenetic Alterations | We hypothesized that genetic variations in miRNA binding sites located in mucin genes may modulate signaling response and the maintenance of genomic stability ultimately affecting cancer susceptibility, efficacy of chemotherapy and survival. | 27803053 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | High consumption of fruit and vegetables offers an advantage in survival among the rising number of men living after a PCa diagnosis, possibly through the epigenetic effect of some nutrients. | 27805317 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF-b1/p38/HSP27 signaling in renal cell carcinoma. | 27806310 |
| Malignant Neoplasms | Epigenetic Alterations | Antisense long noncoding RNAs (lncRNAs) are reported to play a regulating role in carcinogenesis of various human malignancies. | 27806310 |
| Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation has been implicated in prostate carcinogenesis. | 27808252 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The microRNA-635 suppresses tumorigenesis in non-small cell lung cancer. | 27810784 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival. | 27811362 |
| Neoplastic disease, Neoplasms | Epigenetic Alterations | Numerous studies suggest that microRNAs are key regulators of many fundamental biological processes, including neoplasia and tumor progression. | 27811362 |
| ovarian neoplasm | Epigenetic Alterations | The potential role of microRNAs in ovarian cancer has attracted much attention in recent years. | 27811362 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | miR-222 is one of those miRNAs that has attracted much attention for its multiple roles in human diseases, especially cancer. | 27811362 |
| Malignant Mesothelioma of Peritoneum | Epigenetic Alterations | Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. | 27813512 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | We aimed to assess the diagnostic potential of epigenetic changes in urine DNA from bladder cancer cases at various clinico-pathological stages of the disease. | 27814275 |
| Neoplasms | Epigenetic Alterations | microRNAs (miRNAs) plays an important role in tumor development and progression and act as oncogenes or tumor suppressor genes in the carcinogenesis process. | 27814278 |
| Admitting diagnosis | Epigenetic Alterations | The discovery of extracellular microRNAs (miRNAs) in CSF raises the possibility that miRNA may serve as novel biomarkers of AD. | 27814298 |
| Primary malignant neoplasm | Epigenetic Alterations | In addition, there is a great demand for novel biomarkers for the prognosis of cancer, which prompted us to transfer a high content miRNA screening initially performed to identify bioprocess relevant miRNAs in Chinese hamster ovary (CHO) cells to human cancer cell lines . | 27821806 |
| Neoplasms | Epigenetic Alterations | The installation of de novo tumor suppressive function by using pro-apoptotic miRNAs might be a promising therapeutic approach. | 27821806 |
| Ovarian Carcinoma | Epigenetic Alterations | The recovery rate of apoptosis inducing miRNAs was highest in the human ovarian carcinoma cell line SKOV3. | 27821806 |
| Cessation of life | Epigenetic Alterations | Ectopic introduction of these miRNAs lead to enhanced activation of caspase-dependent death signaling and an induction of the pro-apoptotic proteins Bak1 and Bax and a reduced expression of Bcl2 and Bcl-xL. | 27821806 |
| ovarian neoplasm | Epigenetic Alterations | Investigation on tissue specific effects of pro-apoptotic micro RNAs revealed miR-147b as a potential biomarker in ovarian cancer prognosis. | 27821806 |
| Ulcerative Colitis | Epigenetic Alterations | Downregulation of MicroRNA-21 in Colonic CD3+ T Cells in UC Remission. | 27824649 |
| Ulcerative Colitis, ibudilast, Inflammatory Bowel Diseases | Epigenetic Alterations | In active inflammatory bowel disease (IBD), microRNA expression profiling consistently features disease-specific signatures, and microRNA-21 (miR-21) has been shown to be upregulated in the inflamed colon of patients with active ulcerative colitis (UC). | 27824649 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Two novel BRM promoter polymorphisms (BRM-741 and BRM-1321) are associated with reversible epigenetic silencing of BRM protein expression.Experimental Design: Advanced NSCLC patients from the Princess Margaret (PM) cohort study and from the CCTG BR.24 clinical trial were genotyped for BRM promoter polymorphisms. | 27827316 |
| Carcinoma of lung | Epigenetic Alterations | We find that the expression of piRNAs encoded at DLK1-DIO3 enhances the prognostic potential of small non-coding RNAs specific to this locus in predicting patient outcome, further emphasizing the importance of regulation at this locus in lung cancer. | 27829231 |
| Lung diseases | Epigenetic Alterations | Deregulated expression of a microRNA (miRNA) cluster mapping to this locus was also associated with patient outcome, suggesting the importance of this locus to lung cancer disease phenotypes. | 27829231 |
| Malignant Neoplasms, cervical cancer | Epigenetic Alterations | It has been reported that miRNAs is deregulated in diverse human cancers, involving human cervical cancer. | 27829233 |
| Feel Pain | Epigenetic Alterations | Are Epigenetic Factors Implicated in Chronic Widespread Pain? | 27832094 |
| Breast Carcinoma | Epigenetic Alterations | Genome-wide miRNA expression may be useful for predicting breast cancer risk and/or for the early detection of breast cancer. | 27833082 |
| Breast Carcinoma | Epigenetic Alterations | Among the 41 miRNA, 20 miRNAs were detectable in serum, and predicted breast cancer occurrence within 18 months of blood draw (accuracy 53%, P=0.06). | 27833082 |
| Breast Carcinoma | Epigenetic Alterations | These results serve as proof-of-principle that miRNAs in women without breast cancer may be useful for predicting breast cancer risk and/or as an adjunct for breast cancer early detection. | 27833082 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Knockdown of long non-coding RNA CCAT2 suppressed proliferation and migration of glioma cells. | 27833083 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Thus we assessed genome-wide genetic, transcriptional and epigenetic alterations in BM-MSC derived from AML patients (AML BM-MSC). | 27833093 |
| Papillary thyroid carcinoma | Epigenetic Alterations | Long intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer. | 27833134 |
| Neoplasms | Epigenetic Alterations | A number of long non-coding RNAs (lncRNAs) have been found to play critical roles in oncogenesis and tumor progression. | 27833134 |
| Primary malignant neoplasm | Epigenetic Alterations | It has been reported that miRNA-22 (miR-22) is involved in the invasion of some cancer cell lines. | 27834627 |
| Astrocytoma | Epigenetic Alterations | Promotion of astrocytoma cell invasion by micro RNA-22 targeting of tissue inhibitor of matrix metalloproteinase-2. | 27834627 |
| Ischemic stroke | Epigenetic Alterations | Although peripheral blood mRNA and micro-RNA change after ischemic stroke, any role for long noncoding RNA (lncRNA), which comprise most of the genome and have been implicated in various diseases, is unknown. | 27834745 |
| Cerebrovascular accident | Epigenetic Alterations | Altered Expression of Long Noncoding RNAs in Blood After Ischemic Stroke and Proximity to Putative Stroke Risk Loci. | 27834745 |
| Right arm | Epigenetic Alterations | MicroRNAs have emerged as crucial regulators of the immune system, whose expression is deregulated in RA. | 27834806 |
| Rheumatoid Arthritis | Epigenetic Alterations | X-Linked miRNAs Associated with Gender Differences in Rheumatoid Arthritis. | 27834806 |
| Right arm | Epigenetic Alterations | X-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention. | 27834806 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Identification of a seven-miRNA signature as prognostic biomarker for lung squamous cell carcinoma. | 27835574 |
| Primary malignant neoplasm | Epigenetic Alterations | Twelve of the 133 most significantly altered miRNAs were associated with overall survival (OS) across different clinical subclasses of the Cancer Genome Atlas (TCGA) LUSC cohort. | 27835574 |
| Neoplasms | Epigenetic Alterations | Most significantly altered miRNAs were identified between tumor and normal samples. | 27835574 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | In tumor lesions of ARL4C-positive lung SCC, 5hmC was frequently detected and DNA methylation in the 3-UTR of ARL4C gene was lower than in non-tumor regions, which were consistent with the Cancer Genome Atlas dataset. | 27835592 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma. | 27835592 |
| Malignant Neoplasms, Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Recent evidence shows that miRNAs are dysregulated in a variety of cancers including gastric cancer (GC), and emerging as key oncogenes or tumor suppressors. | 27835599 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been suggested to have important causal roles in gastric cancer. | 27835598 |
| Hollings Cancer Center | Epigenetic Alterations | The miRNA profiles of CD90+ and CD90- HCC cells were analyzed using a miRNA microarray and quantitative real-time PCR (qRT-PCR). | 27835990 |
| Hollings Cancer Center | Epigenetic Alterations | MicroRNAs (miRNAs) play crucial roles regulating CD133+ and EpCAM+ CSCs in HCC, although it is unclear whether miRNAs regulate CD90+ CSCs in HCC. | 27835990 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Purpose: Epigenetic silencing of tumor suppressor genes (TSG) is an acquired abnormality observed in cancer and is prototypically linked to DNA methylation. | 27836862 |
| Spinal Fractures | Epigenetic Alterations | Expression of microRNAs that regulate bone turnover in the serum of postmenopausal women with low bone mass and vertebral fractures. | 27836951 |
| Cardiovascular Diseases | Epigenetic Alterations | DNA methylation has been shown to regulate inflammatory pathways that are responsible for the development of cardiovascular diseases. | 27838013 |
| Breast Carcinoma | Epigenetic Alterations | Circulating microRNAs (miRNAs) are increasingly recognized as strong biomarkers, and we previously developed a 9-miRNA profile using serum and LNA-based qPCR that effectively stratified patients with early stage breast cancer vs. healthy women. | 27839676 |
| Breast Carcinoma | Epigenetic Alterations | The performance of the circulating 9-miRNA profile was analyzed in 116 of these women, including 36 with breast cancer (aged 50-74), following a standardized protocol that mimicked a routine clinical set-up. | 27839676 |
| Breast Carcinoma | Epigenetic Alterations | We propose that this miRNA profile combined with mammography will increase the overall accuracy of early detection of breast cancer. | 27839676 |
| Liver carcinoma | Epigenetic Alterations | Low levels of circulating microRNA-26a/29a as poor prognostic markers in patients with hepatocellular carcinoma who underwent curative treatment. | 27839726 |
| Movement Disorders | Epigenetic Alterations | Our findings support the potential of miRNA panels as biomarkers for movement disorders and may provide more insights into the pathological mechanisms related to these disorders. | 27844283 |
| Cerebellar degeneration, Cerebellar Ataxia | Epigenetic Alterations | In MSA, we also observed that miR-24 and miR-148b correlated with cerebellar ataxia symptoms, suggesting that these miRNAs are involved in cerebellar degeneration in MSA. | 27844283 |
| Primary malignant neoplasm | Epigenetic Alterations | Analyzing gene expression and DNA methylation in The Cancer Genome Atlas cohort revealed an inverse correlation of gene expression and DNA methylation, suggesting that DNA hypermethylation is regulating the expression of UQCRC1 and UQCRFS1. | 27845902 |
| Stomach Carcinoma | Epigenetic Alterations | SLC7A5, who is also named LAT-1, has been validated as a promoter regulated by miRNA-126 in our previous research for gastric cancer cells. | 27846244 |
| Cerebral Infarction | Epigenetic Alterations | Plasma MicroRNA-16 Is a Biomarker for Diagnosis, Stratification, and Prognosis of Hyperacute Cerebral Infarction. | 27846323 |
| Cerebrovascular accident | Epigenetic Alterations | MicroRNAs (miRNAs) that regulate gene expression following stroke have potential use as prognostic markers of HACI. | 27846323 |
| Inflammatory Bowel Diseases | Epigenetic Alterations | MicroRNA panels show promise as diagnostic biomarkers for the subtyping of inflammatory bowel disease. | 27855604 |
| ibudilast | Epigenetic Alterations | Knowledge of microRNAs in IBD has expanded recently and supports that microRNAs play an important role. | 27855604 |
| Ulcerative Colitis | Epigenetic Alterations | Among them, a panel of 11 microRNAs was aberrantly expressed between UC and CD. | 27855604 |
| Ulcerative Colitis | Epigenetic Alterations | Identification of differentially expressed microRNAs in UC and CD supports the hypothesis that UC and CD are regulated by distinct pathophysiologic mechanisms. | 27855604 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Single nucleotide polymorphisms within MicroRNAs, MicroRNA targets, and MicroRNA biogenesis genes and their impact on colorectal cancer survival. | 27859935 |
| Malignant tumor of colon | Epigenetic Alterations | We have shown that single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, miRNA target genes, and miRNA biogenesis genes minimally contribute to colon cancer risk. | 27859935 |
| Injury of liver | Epigenetic Alterations | Serum miRNA-122 combined with albumin accurately identified subjects who died within 6 months of drug induced liver injury. | 27860186 |
| Injury of liver | Epigenetic Alterations | Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance. | 27860186 |
| Cessation of life | Epigenetic Alterations | Lower levels of miRNAs-122, -4463 and -4270 were associated with death within 6 months (P<.05). | 27860186 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | MicroRNA-383 is a tumor suppressor in human lung cancer by targeting endothelial PAS domain-containing protein 1. | 27862077 |
| Malignant Neoplasms | Epigenetic Alterations | The role of microRNA (miR)-383 has been controversial in the initiation and progression of different cancers. | 27862077 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA-383 levels were analyzed in noncancerous versus cancerous human lung tissues and in normal versus lung cancer cell lines. | 27862077 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA-383 was downregulated in lung cancer tissue and cell lines. | 27862077 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | MicroRNA-383 is a tumor suppressor in human lung cancer by inhibiting EPAS1, both of which could serve as potential therapeutic targets in the treatment of lung cancer. | 27862077 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | MicroRNA-383 is a tumor suppressor in human lung cancer, which functions to inhibit tumorigenesis of lung cancer cells both in vitro and in vivo. | 27862077 |
| Carcinoma of lung | Epigenetic Alterations | Both microRNA-383 and EPAS1 could serve as potential therapeutic targets in the treatment of lung cancer. | 27862077 |
| Aggressive behavior, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | ZFP36L2 promotes cancer cell aggressiveness and is regulated by antitumor microRNA-375 in pancreatic ductal adenocarcinoma. | 27862697 |
| Malignant Neoplasms | Epigenetic Alterations | Expression of microRNA-375 (miR-375) was significantly reduced in miRNA expression signatures of several types of cancers, including PDAC. | 27862697 |
| Malignant Neoplasms | Epigenetic Alterations | Although initially thought to be transcriptional noise, long noncoding RNAs (lncRNAs) are gaining increased attention in human cancers as its diversity function. | 27863388 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | A panel of 46 microRNAs significantly associated with bladder cancer were subsequently monitored in an independent cohort of 121 subjects (61 with active BCa) using quantitative real-time PCR (RT-PCR). | 27863434 |
| Malignant Neoplasms, Breast Carcinoma, Metastasis, Neoplasms | Epigenetic Alterations | MicroRNAs are non-protein coding molecules that play a key role in oncogenesis, tumor progression, and metastasis in many types of malignancies including breast cancer. | 27864119 |
| Neoplasms | Epigenetic Alterations | Polycomb chromobox (CBX) proteins participate in the polycomb repressive complex (PRC1) that mediates epigenetic gene silencing and endows PRC1 with distinct oncogenic or tumor suppressor functions in a cell-type-dependent manner. | 27864346 |
| Primary malignant neoplasm | Epigenetic Alterations | Disruption of epigenetic regulation and characteristic metabolic alterations (known as the Warburg-effect) are well-known hallmarks of cancer. | 27864740 |
| Hematologic Neoplasms, Childhood Leukemia | Epigenetic Alterations | Our results suggest that Warburg-effect related microRNAs may have important role in the pathogenesis of leukemia, and the potential oncogenic property of HDAC4 and SIRT6 cannot be excluded in hematological malignancies. | 27864740 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. | 27868302 |
| Diabetes Mellitus | Epigenetic Alterations | We hypothesize that the levels of specific cytokines and miRNAs vary across the diabetes spectrum and unique signatures associated with them may serve as early biomarkers of the disease and provide insights into respective pathogenetic mechanisms. | 27869909 |
| Prediabetes syndrome | Epigenetic Alterations | Our data suggest that changes in circulating miRNAs and cytokines may have clinical utility as biomarkers of prediabetes. | 27869909 |
| Breast Carcinoma | Epigenetic Alterations | Purpose Epigenetic alterations measured in blood may help guide breast cancer treatment. | 27870562 |
| Primary malignant neoplasm | Epigenetic Alterations | A New MicroRNA Expression Signature for Cervical Cancer. | 27870701 |
| cervical cancer | Epigenetic Alterations | The potential of microRNAs as novel biomarkers in cervical cancer is growing. | 27870701 |
| Infection caused by Helicobacter pylori | Epigenetic Alterations | Helicobacter pylori infection induces aberrant DNA methylation in gastric mucosa. | 27871161 |
| Chronic Kidney Diseases | Epigenetic Alterations | Identification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease. | 27872161 |
| Disease | Epigenetic Alterations | Next-generation sequencing approaches have revealed that exosomes are enriched in noncoding RNAs and thus exhibit great potential for sensitive nucleic acid biomarkers in various human diseases. | 27872161 |
| Chronic Kidney Diseases | Epigenetic Alterations | Thereby, miRNA-181a appeared as the most robust and stable potential biomarker, being significantly decreased by about 200-fold in exosomes of CKD patients compared to healthy controls. | 27872161 |
| Malignant tumor of colon, Postoperative cognitive dysfunction | Epigenetic Alterations | Preoperative Serum MicroRNA-155 Expression Independently Predicts Postoperative Cognitive Dysfunction After Laparoscopic Surgery for Colon Cancer. | 27872469 |
| Malignant tumor of colon, Osteochondritis Dissecans | Epigenetic Alterations | CONCLUSIONS The serum expression of miRNA-155 is an independent predictive factor for POCD after laparoscopic surgery for colon cancer. | 27872469 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively). | 27874289 |
| Endometrial Neoplasms | Epigenetic Alterations | We identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors. | 27874289 |
| Endometrial Carcinoma | Epigenetic Alterations | Epigenetic changes as prognostic predictors in endometrial carcinomas. | 27874289 |
| Malignant Neoplasms | Epigenetic Alterations | The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers. | 27875818 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | The role of long noncoding RNA HOTAIR in the acquired multidrug resistance to imatinib in chronic myeloid leukemia cells. | 27875938 |
| Right arm | Epigenetic Alterations | Functional evidence is still lacking but the results reinforce further study of epigenetic modifications influencing the progression of RA. | 27876072 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-kB, and Up-regulating Expression of MicroRNA-21. | 27876571 |
| Genus Fusobacterium | Epigenetic Alterations | Fusobacterium nucleatum activates Toll-like receptor 4 signaling to MYD88, leading to activation of the nuclear factor-kB and increased expression of miR21; this miRNA reduces levels of the RAS GTPase RASA1. | 27876571 |
| cervical cancer | Epigenetic Alterations | MicroRNA-362 is downregulated in cervical cancer and inhibits cell proliferation, migration and invasion by directly targeting SIX1. | 27878258 |
| Carcinogenesis, cervical cancer | Epigenetic Alterations | Mounting evidence demonstrates that microRNAs play important roles in the carcinogenesis and progression of cervical cancer. | 27878258 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Aberrant expression of microRNAs has been identified as regulators of biological processes of hepatocellular carcinoma (HCC) by negatively regulating protein-coding mRNAs. | 27878280 |
| Malignant Neoplasms, Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) significantly contributes to the progression of many human cancers, while glioma stem cells (GSCs) are believed to be responsible for tumor progression. | 27878295 |
| Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, Neoplasms | Epigenetic Alterations | MicroRNA-148a (miR-148a) has been reported to be deregulated in different tumor types, whereas the biological function of miR-148a in renal cell carcinoma (RCC) largely remains unexplored. | 27878305 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Long noncoding RNA GAS5 inhibits malignant proliferation and chemotherapy resistance to doxorubicin in bladder transitional cell carcinoma. | 27878359 |
| Metastasis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | High expression of long non-coding RNA ATB indicates a poor prognosis and regulates cell proliferation and metastasis in non-small cell lung cancer. | 27878433 |
| Respiratory Distress Syndrome, Newborn | Epigenetic Alterations | Temporal Changes in Microrna Expression in Blood Leukocytes from Patients with the Acute Respiratory Distress Syndrome. | 27879560 |
| Respiratory Distress Syndrome, Adult | Epigenetic Alterations | 21 miRNA were expressed at increased levels in blood leukocytes at the onset of ARDS compared with healthy controls. | 27879560 |
| Respiratory Distress Syndrome, Adult, Inflammation | Epigenetic Alterations | Expression of miRNA is increased in blood leukocytes of patients with ARDS at day 0 and day 3 and rises further by day 7, when systemic inflammation is subsiding. | 27879560 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis. | 27881157 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | A combination of these two miRNAs may be a potential biomarker for AE-IPF from IPF. | 27881157 |
| Axis, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | An miRNA-DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia. | 27881579 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Purpose: Azacitidine inhibits DNA methyltransferases, including DNMT1, and is currently the standard of care for patients with higher-risk myelodysplastic syndrome (HRMDS) or low blast count acute myeloid leukemia (AML).Experimental Design: The expression of 754 miRNAs was compared in azacitidine-resistant and azacitidine-sensitive myelodysplastic syndrome cells. | 27881579 |
| Alzheimers Disease | Epigenetic Alterations | Circadian alterations during early stages of Alzheimers disease are associated with aberrant cycles of DNA methylation in BMAL1. | 27883893 |
| Admitting diagnosis | Epigenetic Alterations | We hypothesized that aberrant DNA methylation may affect circadian rhythms in AD. | 27883893 |
| Admitting diagnosis | Epigenetic Alterations | Hence, aberrant epigenetic patterns may be linked to circadian alterations in AD. | 27883893 |
| Malignant neoplasm of esophagus | Epigenetic Alterations | MicroRNAs have been associated with prognosis in oesophageal cancer (EC), suggesting that miRNAs could play a role in guiding treatment decisions. | 27885434 |
| Rheumatoid Arthritis | Epigenetic Alterations | DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis. | 27885849 |
| Right arm | Epigenetic Alterations | DNA methylation at diagnosis is associated with disease-modifying antirheumatic drug treatment response in early RA. | 27885849 |
| Post-Traumatic Stress Disorder | Epigenetic Alterations | Subjects with PTSD showed a higher DNA methylation of four CpG sites at the BDNF promoter compared with those without PTSD. | 27886370 |
| Post-Traumatic Stress Disorder | Epigenetic Alterations | This study demonstrated an association between higher DNA methylation of the BDNF promoter and PTSD diagnosis in combat-exposed individuals. | 27886370 |
| Post-Traumatic Stress Disorder | Epigenetic Alterations | Epigenetic alterations of the BDNF gene in combat-related post-traumatic stress disorder. | 27886370 |
| Nerve Degeneration, Primary malignant neoplasm | Epigenetic Alterations | Epigenetic modifications to cytosine are known to alter transcriptional states and deregulate gene expression in cancer, embryonic development, and most recently in neurodegeneration. | 27889911 |
| Admitting diagnosis, Nerve Degeneration | Epigenetic Alterations | These data suggest alterations in epigenetic regulation of genes may play an early role in the progression of AD as well as other types of neurodegeneration. | 27889911 |
| SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Moreover, aberrant DNA methylation was also found as a dominant mechanism of disease progression in myelodysplastic syndrome (MDS). | 27891827 |
| Malignant Neoplasms, Childhood Leukemia | Epigenetic Alterations | Epigenetic inactivation of GPX3 has been identified in various cancers including leukemia. | 27891827 |
| Behavior | Epigenetic Alterations | Aberrant DNA methylation seems to be associated with prostate cancer behavior. | 27892790 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression. | 27893417 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Together, our combined results elucidated genetic and epigenetic silencing of miR-506-3p enhances COTL1 oncogene expression to foster NSCLC progression. | 27893417 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Importantly, we also found GATA3 transcriptionally actives miR-506-3p expression, and the long non-coding RNA urothelial carcinoma-associated 1 (UCA1) exerts oncogenic function in NSCLC by competitively sponging miRNA-506. | 27893417 |
| Malignant Neoplasms, Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Although previous studies suggested that microRNA-506-3p (miR-506-3p) was frequently downregulated, and functioned as a tumor suppressor in several cancers, the biological role and intrinsic regulatory mechanisms of miR-506-3p in non-small cell lung cancer (NSCLC) remain elusive. | 27893417 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | These results indicate that aberrant DNA methylation may be a potential biomarker for the diagnosis of ESCC. | 27893424 |
| Hollings Cancer Center | Epigenetic Alterations | We screened a microRNA (miRNA) microarray to identify potential serum biomarkers for BM in HCC patients. | 27893432 |
| Prostate Cancer Pathway | Epigenetic Alterations | MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. | 27893706 |
| Prostate Cancer Pathway, Secondary malignant neoplasm of prostate, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Here we demonstrate for the first time that a microRNA component of this region-miR-383-is frequently downregulated in prostate cancer, has a critical role in determining tumor-initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells. | 27893706 |
| Sessile Serrated Adenoma/Polyp | Epigenetic Alterations | Comprehensive DNA Methylation and Mutation Analyses Reveal a Methylation Signature in Colorectal Sessile Serrated Adenomas. | 27896617 |
| Breast Carcinoma | Epigenetic Alterations | Long intergenic non-coding RNA expression signature in human breast cancer. | 27897201 |
| Primary malignant neoplasm | Epigenetic Alterations | Epigenetic markers based on differential methylation of DNA sequences are used in cancer screening and diagnostics. | 27898666 |
| Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Epigenetic Alterations | Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes. | 27899485 |
| Metabolic Diseases | Epigenetic Alterations | MicroRNA-122 (miR-122) is abundant in the liver and involved in lipid homeostasis, but its relevance to the long-term risk of developing metabolic disorders is unknown. | 27899485 |
| Carotid Stenosis | Epigenetic Alterations | Circulating MicroRNAs as Novel Biomarkers of Stenosis Progression in Asymptomatic Carotid Stenosis. | 27899750 |
| Dental Plaque | Epigenetic Alterations | Recent studies suggest a regulatory function for several microRNAs (miRNAs) on the evolution of carotid plaque, but its role in ACAS progression is mostly unknown. | 27899750 |
| Osteoporotic Fractures | Epigenetic Alterations | MiR-148a the epigenetic regulator of bone homeostasis is increased in plasma of osteoporotic postmenopausal women. | 27900532 |
| Secondary malignant neoplasm of female breast | Epigenetic Alterations | Unravelling site-specific breast cancer metastasis: a microRNA expression profiling study. | 27902972 |
| Metastasis | Epigenetic Alterations | MicroRNAs (miRs) are important regulators of many physiological and pathological processes, including metastasis. | 27902972 |
| Cardiovascular Diseases | Epigenetic Alterations | DNA methylation may mediate effects of air pollution on cardiovascular disease. | 27903268 |
| Arteriosclerosis | Epigenetic Alterations | Epigenetic markers may provide insights into mechanisms underlying environmental factors in complex diseases like atherosclerosis. | 27903268 |
| artery calcification | Epigenetic Alterations | DNA methylation of CDKN2B may play a potential role in artery calcification. | 27905995 |
| Colorectal Cancer Pathway, Metastasis | Epigenetic Alterations | microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5. | 27906093 |
| Degenerative polyarthritis | Epigenetic Alterations | microRNA-140-5p (miR-140) has been shown to be involved in cartilage development and osteoarthritis (OA) pathogenesis. | 27906093 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Here, we illustrate that miR-148a-3p is frequently downregulated in bladder cancer and that its expression may be regulated by DNA methylation. | 27906180 |
| Neoplasms | Epigenetic Alterations | A series of lncRNAs (long noncoding RNAs) have been reported as candidate biomarkers in a variety of tumors. | 27906682 |
| MIR29A gene | Epigenetic Alterations | In addition, miRNAs, including hsa-miR-29a, hsa-miR-192, and hsa-miR-144, were upregulated hub nodes in the two regulatory networks. | 27906902 |
| MIR29A gene, IFNG wt Allele | Epigenetic Alterations | CONCLUSIONS Genes including TAF1 and MAFK, and miRNAs including hsa-miR-29a, hsa-miR-192, and hsa-miR-144 might be potential target genes and important miRNAs for IFG and T2DM. | 27906902 |
| Clinical Coordinator, Colorectal Cancer Pathway, Malignant Neoplasms | Epigenetic Alterations | MicroRNA-21 (miR-21) expression was quantified by real-time qRT-PCR in peripheral blood and saliva samples obtained from patients diagnosed with colorectal cancer (CRC) of varying degrees of malignancy and healthy volunteers. | 27910062 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The connection among the biochemical pathways in which they are involved (DNA methylation, epigenetic marks on histones and RNA cap methylation) could explain the concentration changes with PCa and supports, once again, the role of metabolomics in upstream processes. | 27910903 |
| Malignant Neoplasms, SF3B1 wt Allele, Acute lymphocytic leukemia, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetic changes including aberrant HDAC activity are associated with cancers, including myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL). | 27911138 |
| Autoimmune state, Rheumatoid Arthritis, Right arm | Epigenetic Alterations | MicroRNAs (miRs) represent a part of epigenetic control of autoimmunity gaining increasing attention in rheumatoid arthritis (RA). | 27915033 |
| Right arm | Epigenetic Alterations | Up-regulation of survivin in smokers suggests its role as effector of the adverse epigenetic control in RA. | 27915033 |
| Right arm | Epigenetic Alterations | Since cigarette smoking plays important role in RA pathogenesis and reprograms transcriptional profile of miRNAs, we ask if the onco-protein survivin, a novel biomarker of RA, may provide a link between smoking and miRNA. | 27915033 |
| Myeloid Leukemia, Chronic, Neoplasms, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Multiple omics analysis revealed aberrant alterations of genomics and epigenetics were significantly associated with CPT1A expression, including up- and down-regulation of oncogenes and tumor suppressor, activation and inhibition of leukemic (AML, CML) and immune activation pathways, hypermethylation enrichments on CpG island and gene promoter regions. | 27916548 |
| Herpes zoster disease | Epigenetic Alterations | Evaluation of microRNA Expression in Patients with Herpes Zoster. | 27918431 |
| Hertz (Hz) | Epigenetic Alterations | The results showed that the serum miRNA expression profiles in 41 HZ patients were different from those of control subjects. | 27918431 |
| Communicable Diseases | Epigenetic Alterations | It was proposed that circulating microRNAs (miRNAs) in body fluids could potentially indicate infection. | 27918431 |
| Herpes zoster disease | Epigenetic Alterations | However, the connection between herpes zoster and circulating miRNAs has not been demonstrated. | 27918431 |
| Hertz (Hz) | Epigenetic Alterations | Specifically, 18 miRNAs were up-regulated and 126 were down-regulated more than two-fold in HZ patients compared with controls. | 27918431 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer. | 27919977 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Dysregulation pattern of microRNA-7 (miR-7) and the clinical significance of its expression in colorectal cancer (CRC) are unresolved. | 27919977 |
| Coinfection | Epigenetic Alterations | We demonstrated that endogenous miRNA-200a-3p, whose expression was synergistically induced following co-infection, indirectly regulates CXCL10 expression by targeting suppressor of cytokine signaling-6 (SOCS-6), a well-known regulator of the JAK-STAT signaling pathway. | 27922126 |
| Complete atrioventricular block | Epigenetic Alterations | Here, we explore the hypothesis that NAs may cause persistent epigenetic changes during prolonged NAs therapy in CHB patients. | 27922198 |
| ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal Adenocarcinoma | Epigenetic Alterations | miRNA-124 (miR-124) expression was known to be downregulated in patients with pancreatic ductal adenocarcinoma (PDAC). | 27922430 |
| Neoplasms | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have recently been shown to play critical roles in regulating neurogenesis and brain tumor progression. | 27923049 |
| Carcinoma of lung | Epigenetic Alterations | Smoking-associated DNA methylation markers predict lung cancer incidence. | 27924164 |
| Carcinoma of lung, Liquid Chromatography | Epigenetic Alterations | Newly established blood DNA methylation markers that are strongly associated with smoking might open new avenues for lung cancer (LC) screening. | 27924164 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | MicroRNAs (miRNAs) play key roles in the pathogenesis of RCC. | 27924503 |
| Polyp of large intestine | Epigenetic Alterations | The miRNA landscape of colorectal polyps. | 27925331 |
| Neoplasms | Epigenetic Alterations | We compared these miRNA expression profiles in polyps to miRNA expression in microsatellite unstable (MSI) and stable (MSS) tumors. | 27925331 |
| Admitting diagnosis | Epigenetic Alterations | The major differences in miRNA expression were observed between AD and SSP and AD and HP, with few differences in expression noted for SSP and HP. | 27925331 |
| Neoplasms | Epigenetic Alterations | MiRNA expression in the SSP and HP tumors almost uniformly go in opposite directions from the MSS tumor miRNA expression and was mixed with MSI tumors. | 27925331 |
| polyps, Adenoma | Epigenetic Alterations | Expression of miRNAs in adenomas and polyps may importantly contribute to these pathways. | 27925331 |
| polyps | Epigenetic Alterations | There were 70 miRNAs with differential expression by polyp type with a fold change <0.75 or >1.34 after adjusting for multiple comparisons. | 27925331 |
| Adenocarcinoma of lung (disorder), "Alzheimers Disease Assessment Scale-Cognitive CDISC Version Questionnaire | Epigenetic Alterations | In this study, we aimed to identify novel drivers that would be epigenetically altered through aberrant methylation in early-stage lung adenocarcinoma (LADC), regardless of the presence or absence of tobacco smoking-induced epigenetic field defects. | 27926516 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | Long Noncoding RNA Expression Signatures of Abdominal Aortic Aneurysm Revealed by Microarray. | 27927271 |
| Carcinogenesis, Neoplastic disease | Epigenetic Alterations | The serrated neoplasia pathway of colorectal carcinogenesis is characterized by BRAF mutation and aberrant DNA methylation, which have not been reported on Korean patients. | 27930579 |
| Esophageal carcinoma | Epigenetic Alterations | Up-Regulation of MicroRNA-133a Inhibits the MEK/ERK Signaling Pathway to Promote Cell Apoptosis and Enhance Radio-Sensitivity by Targeting EGFR in Esophageal Cancer In Vivo and In Vitro. | 27933650 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | Epigenetic aberrations have been identified as biomarkers to predict the risk of Alzheimers disease (AD). | 27935556 |
| Admitting diagnosis | Epigenetic Alterations | These results suggest that elevation of peripheral BDNF promoter methylation might be used as potential epigenetic biomarkers for predicting the conversion from aMCI to AD. | 27935556 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | MicroRNA-203 predicts human survival after resection of colorectal liver metastasis. | 27935861 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Some microRNAs (miRNAs) become deregulated in cancers and contribute to cancer progression. | 27935861 |
| Neoplasms | Epigenetic Alterations | We employed next-generation sequencing of small-RNAs to profile miRNAs in solid tumors obtained from 38 patients who underwent hepatectomy for CRLM. | 27935861 |
| Celiac Disease | Epigenetic Alterations | Proinflammatory cytokine interferon-g and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease. | 27936497 |
| Primary malignant neoplasm | Epigenetic Alterations | Several miRNAs are aberrantly expressed in cancer. | 27939727 |
| Prostate Cancer Pathway | Epigenetic Alterations | PITX2 DNA Methylation as Biomarker for Individualized Risk Assessment of Prostate Cancer in Core Biopsies. | 27939865 |
| Carcinoma, Ovarian Epithelial, Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNA (lncRNA) has been recognized as a regulator of gene expression, and the dysregulation of lncRNAs is involved in the progression of many types of cancer, including epithelial ovarian cancer (EOC). | 27941916 |
| Primary malignant neoplasm | Epigenetic Alterations | An integrated approach, combining the detection of ALU fragments and cancer type-specific epigenetic alteration, can improve diagnostic efficiency and better define the prognostic value for CRC disease. | 27943272 |
| Primary central nervous system lymphoma | Epigenetic Alterations | Our data demonstrated that epigenetic alterations in the promoter region downregulated SHP1 expression in PCNSL patients. | 27959415 |
| Primary central nervous system lymphoma | Epigenetic Alterations | Therapeutical regimens with epigenetic modifiers may be a potential option for patients with PCNSL. | 27959415 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes. | 27965295 |
| Ameloblastoma | Epigenetic Alterations | However, ameloblastoma ncRNA expression data is lacking. | 27965463 |
| Primary malignant neoplasm | Epigenetic Alterations | New evidence suggests that non-coding RNAs (ncRNAs) play a critical role in tumourgenesis and prognosis of cancer. | 27965463 |
| Parkinsonian Disorders | Epigenetic Alterations | MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian. | 27965467 |
| Synucleinopathies | Epigenetic Alterations | MicroRNAs (miRNAs) play a key role in the metabolism of a-synuclein but the mechanism involved in synucleinopathy remains unclear. | 27965467 |
| palladium | Epigenetic Alterations | The results revealed that 11 microRNAs were differently expressed in CSF, emphatically as miR-144-5p, miR-200a-3p and miR-542-3p, which were dramatically up-regulated in both A53T-transgenic mice and PD patients, and had a helpful accuracy for the PD prediction. | 27965467 |
| palladium | Epigenetic Alterations | Taken together, our data suggested that miRNAs in CSF, such as miR-144-5p, miR-200a-3p and miR-542-3p, may be useful to the PD diagnosis as potential biomarkers. | 27965467 |
| Malignant tumor of colon | Epigenetic Alterations | We developed a prognostic 4-microRNA expression signature for colon cancer patient survival, and validated miR-130a sponge could sensitized 5-FU anti-cancer effect. | 27974852 |
| Malignant tumor of colon | Epigenetic Alterations | In the end, we test the selected miRNAs in HT126 colon cancer cells to validate its anti-cancer effect. | 27974852 |
| Coronary Artery Disease | Epigenetic Alterations | Circulating microRNAs (miRNAs) have been proved to serve as biomarkers for diagnosis and assessment of prognosis of coronary artery disease (CAD). | 27976798 |
| Breast Carcinoma | Epigenetic Alterations | Purpose: In breast cancer models, combination epigenetic therapy with a DNA methyltransferase inhibitor and a histone deacetylase inhibitor led to reexpression of genes encoding important therapeutic targets, including the estrogen receptor (ER). | 27979916 |
| Psoriasis | Epigenetic Alterations | Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis. | 27980695 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Although genetic studies have identified chromosomal aberrations or specific mutations, epigenetic changes have been poorly characterized in CLL. | 27980696 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Despite a slight deregulation in CLL cells compared with normal B cells, we identified a significant association between TET/IDH gene expression and prognosis, suggesting that epigenetic changes could potentially be associated with disease progression. | 27980696 |
| Neoplasms | Epigenetic Alterations | Our study provides evidence of alterations in the expression of apoptosis-regulating miRNAs in salivary gland tumors, suggesting possible involvement of these microRNAs in salivary gland tumorigenesis. | 27981346 |
| Neoplasms | Epigenetic Alterations | Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. | 27981346 |
| Immune System Diseases | Epigenetic Alterations | MicroRNA-155 is a biomarker of T-cell activation and immune dysfunction in HIV-1-infected patients. | 27981723 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic change at the CpG islands in the APC promoter was associated with the silence of its transcript and the loss of protein expression suggesting that this event is the main mechanism regulating the APC expression in breast cancer. | 27983523 |
| Stomach Carcinoma | Epigenetic Alterations | Prognostic value of candidate microRNAs in gastric cancer: A validation study. | 27983528 |
| Stomach Carcinoma | Epigenetic Alterations | Studies have reported the prognostic value of dysregulated microRNAs (miRNAs) in gastric cancer (GC). | 27983528 |
| Prediabetes syndrome, Diabetes Mellitus | Epigenetic Alterations | Global DNA methylation was significantly higher in prediabetes and screen-detected diabetes than in normal glucose tolerance (both p <= 0.033) and in screen-detected diabetes compared to known diabetes on treatment (p = 0.019). | 27990443 |
| Diabetes Mellitus | Epigenetic Alterations | There was no difference in global DNA methylation between known diabetes on treatment and normal glucose tolerance (p > 0.999). | 27990443 |
| Diabetes Mellitus | Epigenetic Alterations | The association of global DNA methylation with screen-detected diabetes but not treated diabetes suggests that glucose control agents to some extent may be reversing DNA methylation. | 27990443 |
| Diabetic Angiopathies | Epigenetic Alterations | The association between NOS3 rs1799983 polymorphisms and DNA methylation suggests gene-epigenetic mechanisms through which vascular diabetes complications develop despite adequate metabolic control. | 27990443 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Five miRNAs that have been consistently found deregulated in PCa (miR-21, miR-141, miR-214, miR-375, and let-7c) were analyzed in urinary pellets from 60 prostate cancer (PCa) patients and 10 healthy subjects by qRT-PCR. | 27990656 |
| Admitting diagnosis | Epigenetic Alterations | The results indicated that DNA methylation in the two regions was significantly increased in AD and aMCI as compared to NCs (P < 0.0001, P < 0.0001, ANOVA). | 27992572 |
| Dementia | Epigenetic Alterations | DNA methylation in the COASY promoter region was associated with CDR Scale Sum of Boxes (CDR-SB), an indicator of dementia severity. | 27992572 |
| Admitting diagnosis | Epigenetic Alterations | In conclusion, DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of AD and aMCI. | 27992572 |
| Primary malignant neoplasm | Epigenetic Alterations | Although aberrant DNA methylation in cfDNA has been reported for more than a decade, its diagnostic accuracy remains unsatisfactory for cancer screening. | 27993161 |
| Breast Carcinoma | Epigenetic Alterations | Circulating cell-free DNA-based epigenetic assay can detect early breast cancer. | 27993161 |
| SHF gene | Epigenetic Alterations | The methylation array analysis identified 12 novel epigenetic markers (JAK3, RASGRF1, CPXM1, SHF, DNM3, CAV2, HOXA10, B3GNT5, ST3GAL6, DACH1, P2RX3, and chr8:23572595) for detecting BC. | 27993161 |
| Aneurysm, Aortic Aneurysm, Abdominal | Epigenetic Alterations | Screening of circulating microRNA biomarkers for prevalence of abdominal aortic aneurysm and aneurysm growth. | 27993388 |
| Aortic Aneurysm, Abdominal | Epigenetic Alterations | MicroRNA (miR) are important regulators of gene expression and biological processes and have recently been suggested as possible biomarkers for abdominal aortic aneurysm (AAA) disease. | 27993388 |
| Neoplasms | Epigenetic Alterations | There is accumulating evidence indicating that long non-coding RNA H19 and its mature product miR-675 play essential roles for tumor growth and progression. | 27994496 |
| sievert, One Vessel Coronary Disease | Epigenetic Alterations | On identifying a novel locus associated with SVS, we assessed its influence on other small vessel disease phenotypes, as well as on messenger RNA (mRNA) expression of nearby genes, and on DNA methylation of nearby CpG sites in whole blood and in the fetal brain. | 27997041 |
| Cholangiocarcinoma, Neoplasms | Epigenetic Alterations | Relative DNA methylation of SHOX2 and SEPT9 was quantified in tumor specimens and matched normal adjacent tissue (NAT) from 71 BTC patients, as well as in plasma samples from an independent prospective cohort of 20 cholangiocarcinoma patients and 100 control patients. | 27999621 |
| Cholangiocarcinoma | Epigenetic Alterations | Elevated DNA methylation levels were also found in plasma derived from cholangiocarcinoma patients. | 27999621 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Micro-RNA signature of lymphovascular space involvement in type 1 endometrial cancer. | 28000202 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNAs (miRNAs/miR) are a group of endogenous, short, non-coding RNAs, the expression profile of which is disturbed in the cartilage of patients with OA. | 28000846 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma. | 28000880 |
| Malignant Neoplasms, Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Increasing number of studies demonstrated that microRNAs are dysregulated in a variety of human cancers, and play significant roles in tumorigenesis and tumor development, including glioma. | 28000880 |
| melanoma | Epigenetic Alterations | The microRNA expression profiles of formalin-fixed, paraffin-embedded melanoma and melanocytic nevi samples were estimated with a microarray and subsequently validated by real-time PCR. | 28005927 |
| melanoma | Epigenetic Alterations | The microarray revealed that the expression of 1,171 microRNAs was altered in melanoma samples compared to melanocytic nevi. | 28005927 |
| Septicemia | Epigenetic Alterations | Accumulating evidences have confirmed that miRNAs have important roles in sepsis. | 28006751 |
| Carcinogenesis | Epigenetic Alterations | Global DNA methylation, possibly influenced by lifestyle and environmental factors, has been suggested to play an active role in carcinogenesis. | 28006848 |
| Dermatologic disorders | Epigenetic Alterations | Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders. | 28008606 |
| Pituitary Adenoma | Epigenetic Alterations | MicroRNA (miR)-26a has been found to be abnormally highly expressed in pituitary adenoma, indicating possible involvement in pathogenesis. | 28012286 |
| Liver neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA (miRNA) sequencing was performed in 50 liver tumors to identify groups of tumors with similar profiles and differentially expressed miRNAs (DEMs). | 28012864 |
| Neoplasms | Epigenetic Alterations | miRNA profiling identified a specific expression profile in DICER1-mutated tumors with a decreased expression of mature miRNAs compared to the other samples. | 28012864 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Inhibition of MicroRNA-149-5p Induces Apoptosis of Acute Myeloid Leukemia Cell Line THP-1 by Targeting Fas Ligand (FASLG). | 28013316 |
| Admitting diagnosis | Epigenetic Alterations | In monozygotic twins discordant for AD we analysed the expression of selected genes, and their possible regulation by epigenetic mechanisms in peripheral blood mononuclear cells, possibly useful to discover biomarkers. | 28017215 |
| Ovarian Serous Adenocarcinoma | Epigenetic Alterations | Circulating miRNA landscape identifies miR-1246 as promising diagnostic biomarker in high-grade serous ovarian carcinoma: A validation across two independent cohorts. | 28017893 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | MicroRNA-33b suppresses the proliferation and metastasis of hepatocellular carcinoma cells through the inhibition of Sal-like protein 4 expression. | 28026002 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs or miRs) have been found to participate in the development and malignant progression of human cancers by negatively mediating the expression of their target genes. | 28026002 |
| Psoriasis, Inflammatory dermatosis | Epigenetic Alterations | Psoriasis is a common chronic inflammatory skin disease caused by genetic and epigenetic factors. | 28028860 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Identifying prognostic biomarkers based on aberrant DNA methylation in kidney renal clear cell carcinoma. | 28029655 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation is regarded as a regulator of gene expression in cancers, which may be a molecular marker of prognosis. | 28029655 |
| Primary malignant neoplasm | Epigenetic Alterations | Molecular mechanisms of alterations in protein tyrosine phosphatases (PTPs) genes in cancer have been previously described and include chromosomal aberrations, gene mutations, and epigenetic silencing. | 28031238 |
| Gastric Mucosa-Associated Lymphoid Tissue Lymphoma, Gastritis | Epigenetic Alterations | We analyzed the expression of 384 miRNAs using TaqMan microRNA assay in a training series of 10 gastric MALT lymphomas, 3 chronic gastritis and 2 reactive lymph nodes. | 28031239 |
| Gastric Mucosa-Associated Lymphoid Tissue Lymphoma | Epigenetic Alterations | Gastric MALT lymphoma is characterized by a specific miRNA expression profile. | 28031239 |
| Gastric Mucosa-Associated Lymphoid Tissue Lymphoma, Gastritis | Epigenetic Alterations | MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis. | 28031239 |
| Gastric Mucosa-Associated Lymphoid Tissue Lymphoma, Chronic gastritis | Epigenetic Alterations | Then, significantly deregulated miRNAs were individually assessed by real-time PCR in a validation series of 16 gastric MALT lymphomas and 12 chronic gastritis. | 28031239 |
| Gastric Mucosa-Associated Lymphoid Tissue Lymphoma | Epigenetic Alterations | Among the differentially expressed miRNAs, a significant overexpression of miR-142-3p and miR-155 and down-regulation of miR-203 was observed in gastric MALT lymphoma when compared to chronic gastritis. | 28031239 |
| melanoma | Epigenetic Alterations | 5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker detectable through immunohistochemistry (IHC) that has been shown to distinguish benign nevi from melanoma with high sensitivity and specificity. | 28032662 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Epigenetic silencing of tumor suppressors contributes to the development and progression of colorectal cancer (CRC). | 28032859 |
| Clinical Coordinator | Epigenetic Alterations | This study aimed to clarify its epigenetic alteration, molecular mechanisms and clinical significance in CRC. | 28032859 |
| Clinical Coordinator | Epigenetic Alterations | It suggests that methylation status of SPOP promoter can be used as a novel epigenetic biomarker and a therapeutic target in CRC. | 28032859 |
| Primary malignant neoplasm | Epigenetic Alterations | Polymorphisms in pre-miRNAs may affect its expression, then have effect on its target mRNAs and be associated with cancer susceptibility. | 28034876 |
| ovarian neoplasm | Epigenetic Alterations | Integration of Population-Level Genotype Data with Functional Annotation Reveals Over-Representation of Long Noncoding RNAs at Ovarian Cancer Susceptibility Loci. | 28035019 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs are small non-coding RNAs that post-transcriptionally regulate many important biological processes and influence cancer phenotypes. | 28035073 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | MicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status. | 28035073 |
| Malignant Neoplasms, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | A total of 72 surgically resected lung adenocarcinoma specimens (19 EGFR-mutated, 17 KRAS-mutated, 16 ALK-rearranged, and 20 triple negative cancers) were screened for 23 microRNAs using quantitative real-time reverse transcriptase polymerase chain reaction. | 28035073 |
| Vascular Invasion Assessment | Epigenetic Alterations | Eight microRNAs were associated with clinicopathological features, such as male sex and ever-smoker status (high miR-373-3p, miR-1343-3p, miR-138-1-3p, and miR-764; low miR-27b-3p) and vascular invasion (high miR-27b-3p; low miR-1343-3p and miR-764). | 28035073 |
| Injury of kidney | Epigenetic Alterations | The expression of miR-192, a specific kidney-enriched miRNA, was assessed in both the plasma and kidney of IRI rats at different time points after kidney injury and compared to renal function and kidney histological changes. | 28035621 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | A novel serum microRNA signature to screen esophageal squamous cell carcinoma. | 28035762 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The diagnostic value of the 5-miRNA signature was validated by an external cohort (60 ESCC vs. 60 NCs). | 28035762 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | In conclusion, we identified a 5-miRNA signature in serum for the detection of ESCC. | 28035762 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Circulating microRNAs (miRNAs) have been used as promising diagnostic biomarkers for esophageal squamous cell carcinoma (ESCC). | 28035762 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Using qRT-PCR, identified serum miRNAs were further confirmed in training (32 ESCC vs. 32 NCs) and testing stages (108 ESCC vs. 96 NCs). | 28035762 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Consequently, five serum miRNAs (miR-20b-5p, miR-28-3p, miR-192-5p, miR-223-3p, and miR-296-5p) were significantly overexpressed in ESCC compared with NCs. | 28035762 |
| Neoplasms | Epigenetic Alterations | Patients with LINE-1 hypomethylated tumors had a significantly worse overall survival compared to patients with a higher level of LINE-1 tumor DNA methylation (HR 1.68, 95% CI 1.03-2.75; p = 0.04). | 28035987 |
| liposarcoma | Epigenetic Alterations | Assessing the clinical value of microRNAs in formalin-fixed paraffin-embedded liposarcoma tissues: Overexpressed miR-155 is an indicator of poor prognosis. | 28036291 |
| Spondylitis | Epigenetic Alterations | To determine the microRNA (miR) signature in ankylosing spondylitis (AS) T helper (Th)17 cells. | 28039186 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | 5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia. | 28039446 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | DNA methylation may epigenetically inactivate tumor suppressor genes in NSCLC. | 28039450 |
| Nerve Degeneration | Epigenetic Alterations | Recent studies suggest that environmental factors may contribute for neurodegeneration through induction of epigenetic modifications, such as DNA methylation, that is carried out by enzymes, such as DNMT1 and DNMT3B. | 28041964 |
| ovarian neoplasm, RAB27A gene | Epigenetic Alterations | MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A. | 28043921 |
| Neoplasms | Epigenetic Alterations | The cluster of microRNAs (miRNAs) in the DLK1-DIO3 genomic imprinted region contains several miRNAs that have a significant regulatory role in tumor proliferation and invasion. | 28043921 |
| ovarian neoplasm | Epigenetic Alterations | One of these miRNAs is miR-134-3p, and its expression changes significantly in human ovarian cancer stem cells (OCSCs) and in CD44-/CD133- ovarian cancer. | 28043921 |
| Vascular Invasion Assessment | Epigenetic Alterations | Serum miRNA-10b-3p was upregulated in the presence of macrovascular invasion (MVI), and those with higher serum miRNA-10b-3p had significantly shorter survival during treatment (P = 0.042). | 28049231 |
| Hollings Cancer Center | Epigenetic Alterations | All of the miRNAs except miR-21 were found to be upregulated in serum samples from HCC patients. | 28049231 |
| Hollings Cancer Center | Epigenetic Alterations | None of the miRNAs assayed differed significantly in terms of expression between the responder and non-responder groups among HCC patients. | 28049231 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | Epigenetic regulation on the gene expression signature in esophagus adenocarcinoma. | 28049580 |
| Diabetes Mellitus | Epigenetic Alterations | The Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of Uyghur in XinJiang in Type 2 Diabetes. | 28050569 |
| Heart failure, Acute myocardial infarction | Epigenetic Alterations | Circulating MicroRNA-145 is Associated with Acute Myocardial Infarction and Heart Failure. | 28051023 |
| Clinical Coordinator | Epigenetic Alterations | We measured WNT5A mRNA level using qRT-PCR and DNA methylation using methylation-specific PCR (MSP) in HCT116, HT29, SW620, HCT8, LoVo, SW480, and Rko CRC cells. | 28051879 |
| Pancreatic carcinoma | Epigenetic Alterations | The role of microRNA in the aberrant autophagy that occurs in pancreatic cancer remains controversial. | 28052003 |
| Hypoxia, Pancreatic carcinoma | Epigenetic Alterations | Because hypoxia is known to induce autophagy, we screened for differentially expressed microRNAs using a miRNA microarray with pancreatic cancer cells cultured under normoxic and hypoxic conditions. | 28052003 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Current knowledge about the role of epigenetics in type 2 diabetes (T2D) remains limited. | 28052964 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Epigenetic Alterations | Our study provides a comprehensive picture of the islet DNA methylome in individuals with and without diabetes and highlights the importance of epigenetic dysregulation in pancreatic islets and T2D pathogenesis. | 28052964 |
| Alzheimers Disease | Epigenetic Alterations | DNA Methylation Profiles of Selected Pro-Inflammatory Cytokines in Alzheimer Disease. | 28053004 |
| Degenerative disorder | Epigenetic Alterations | IL-1b and IL-6 genes are modulated by DNA methylation in different chronic and degenerative diseases; it is also well known that LOAD may have an epigenetic basis. | 28053004 |
| Loading Technique, Neurogenic Inflammation | Epigenetic Alterations | Our analysis provides evidence that neuroinflammation in LOAD is associated with (and possibly mediated by) epigenetic modifications. | 28053004 |
| Symptoms | Epigenetic Alterations | The finding suggests that on exposure with urban environment, risk allele carriers tend to develop asthma symptoms via epigenetic regulation of motif associated with maturation of B-lymphocytes. | 28055272 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer. | 28055956 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Using a quantitative polymerase chain reaction (qPCR) array panel, we analyzed 84 plasma exosomal miRNAs in 10 lung adenocarcinoma patients and 10 matched healthy controls. | 28055956 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Nine candidate miRNAs were selected based on differential expression and previous reports for further evaluating their prognostic roles in 196 NSCLC patients. | 28055956 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | miRNA and mRNA profiling of PBMCs from pooled 17 smokers and 14 COPD subjects was detected by high-throughput microarray. | 28057018 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | The expression of miRNA and mRNA were dysregulated in PBMCs of COPD patients compared with smokers without airflow limitation. | 28057018 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | The regulation network between the dysregulated miRNA and mRNA may provide potential therapeutic targets for COPD. | 28057018 |
| Restenosis, Diabetes Mellitus | Epigenetic Alterations | Serum miRNA-143 expression in the restenosis group was correlated with smoking status, history of diabetes, BSL, and LDL-C (all P < 0.05). | 28057086 |
| Clinical Coordinator | Epigenetic Alterations | Several age-related DNA methylation alterations can be observed during CRC development and progression affecting the mRNA expression of certain CRC- and adenoma-related key control genes. | 28058013 |
| Cachexia, Skeletal muscle structure | Epigenetic Alterations | Small RNAome profiling from human skeletal muscle: novel miRNAs and their targets associated with cancer cachexia. | 28058815 |
| Gallbladder Carcinoma | Epigenetic Alterations | MicroRNA-29c-5p suppresses gallbladder carcinoma progression by directly targeting CPEB4 and inhibiting the MAPK pathway. | 28060377 |
| Primary malignant neoplasm | Epigenetic Alterations | Increasing evidence has highlighted the critical roles of long non-coding RNA (lncRNA) in cancer development and progression. | 28060759 |
| Papillary renal cell carcinoma type 2, Renal Cell Carcinoma Pathway, Conventional (Clear Cell) Renal Cell Carcinoma, Kidney Diseases, Papillary Renal Cell Carcinoma, Refractory Cytopenia of Childhood | Epigenetic Alterations | An increasing body of evidence supports a key role for Keap1/Nrf2 pathway in kidney diseases and renal cell carcinoma (RCC), but data concerning the molecular basis and the clinical effect of its deregulation remain incomplete.Here we present a molecular profiling of the KEAP1 and NFE2L2 genes in five different Renal Cell Carcinoma histotypes by analysing 89 tumor/normal paired tissues (clear cell Renal Carcinoma, ccRCCs; Oncocytomas; Papillary Renal Cell Carcinoma Type 1, PRCC1; Papillary Renal Cell Carcinoma Type 2, PRCC2; and Chromophobe Cell Carcinoma).A tumor-specific DNA methylation of the KEAP1 gene promoter region was found as a specific feature of the ccRCC subtype (18/37, 48.6%) and a direct correlation with mRNA levels was confirmed by in vitro 5-azacytidine treatment. | 28061437 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Analysis of an independent data set of 481 ccRCC and 265 PRCC tumors corroborates our results and multivariate analysis reveals a significant correlation among ccRCCs epigenetic KEAP1 silencing and staging, grading and overall survival.Our molecular results show for the the first time the epigenetic silencing of KEAP1 promoter as the leading mechanism for modulation of KEAP1 expression in ccRCCs and corroborate the driver role of Keap1/Nrf2 axis deregulation with potential new function as independent epigenetic prognostic marker in renal cell carcinoma. | 28061437 |
| Neoplasms | Epigenetic Alterations | Genetic variants in the TGFb-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue. | 28061442 |
| Carcinoma, Colorectal Carcinoma | Epigenetic Alterations | Evaluation of the differential expression between carcinoma and normal mucosa showed that SMAD3 rs12708491 and rs2414937, NFkB1 rs230510 and rs3821958, and RUNX3 rs6672420 were associated with several miRNAs for colorectal carcinoma. | 28061442 |
| Acute myocardial infarction | Epigenetic Alterations | The increased proangiogenic activity of these cells in patients with STEMI and the observation that in particular miR-378 regulates the angiogenic capacity of CD34+ progenitor cells in vivo suggest that this unique miRNA expression pattern represents a novel endogenous repair mechanism activated in acute myocardial infarction. | 28062497 |
| Degenerative polyarthritis | Epigenetic Alterations | Expression of miRNA-140 in Chondrocytes and Synovial Fluid of Knee Joints in Patients with Osteoarthritis. | 28065216 |
| Degenerative polyarthritis | Epigenetic Alterations | Results The expression of miRNA-140 in chondrocytes of knees in OA patients was reduced than that in normal knees, and the between-group difference was statistically significant (F=305.464, P<0.001). | 28065216 |
| Degenerative polyarthritis | Epigenetic Alterations | Conclusion miRNA-140 could be detected in chondrocytes and synovial fluid of OA patients, and its expression was negatively correlated with the severity of OA. | 28065216 |
| Stomach Carcinoma, Helicobacter pylori | Epigenetic Alterations | These findings suggested that the polymorphisms in these miRNAs might be biomarkers for gastric cancer risk and prognosis, especially for populations infected with Helicobacter pylori or who consume alcohol. | 28067243 |
| Neoplasms | Epigenetic Alterations | Regarding DNA methylation, all four SMARCB1/INI1-deficient tumors showed methylation of RASSF1 gene by means of MS-MLPA. | 28069272 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Long noncoding RNA HULC promotes cell proliferation by regulating PI3K/AKT signaling pathway in chronic myeloid leukemia. | 28069548 |
| Carcinogenesis | Epigenetic Alterations | These data suggest that disruption of the differentiated state of precancerous cells via alterations of expression, independent of differences in organs and/or carcinogenetic factors, may be a common feature of DNA methylation alterations during carcinogenesis in multiple organs. | 28069692 |
| Depressive disorder, Depression, CTCAE | Epigenetic Alterations | No significant interrelation was noticed between the number of depression episodes, the severity of depressive disorders and the expression of miRNA selected. | 28073061 |
| Depressive disorder, Depression, CTCAE | Epigenetic Alterations | There is no significant difference in miRNAs expression between patients with recurrent depressive disorders and those in the first episode of depression. | 28073061 |
| Malignant Neoplasms, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Genetic changes are infrequent in acute myeloid leukemia (AML) compared with other malignancies and often involve epigenetic regulators, suggesting that an altered epigenome may underlie AML biology and outcomes. | 28074068 |
| Adenocarcinoma Of Esophagus | Epigenetic Alterations | Among 231 esophageal adenocarcinoma patients of all stages/treatment plans, 38 candidate genetic polymorphisms (17 biogenesis, 9 miRNA targets, 5 pri-miRNA, 7 pre-miRNA) were genotyped and analyzed. | 28074552 |
| Bacterial peritonitis, Ascites | Epigenetic Alterations | MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis. | 28074870 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | The aberrant expressions of long noncoding RNAs have been reported in numerous cancers, which have facilitated the cancer diagnosis. | 28076325 |
| Arthritis, Reactive | Epigenetic Alterations | MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis. | 28076897 |
| Communicable Diseases | Epigenetic Alterations | To provide insights into underlying pathogenic processes associated with antibiotic-refractory LA (postinfectious LA), we analyzed differences in microRNA (miRNA) expression between LA patients with active infection and those with postinfectious LA. | 28076897 |
| Arthritis | Epigenetic Alterations | SF from postantibiotic LA patients also exhibited marked inflammatory (miR-146a, miR-155), wound repair (miR-142), and proliferative (miR-17-92) miRNA signatures, and higher levels of these miRNAs correlated with longer arthritis duration. | 28076897 |
| Malignant Neoplasms, Stomach Carcinoma, Metastasis | Epigenetic Alterations | Recently, non-coding RNAs have been recognized to promote metastasis in various cancers, including gastric cancer. | 28077118 |
| Chronic Kidney Diseases, Fibrosis Assessment | Epigenetic Alterations | Thus, miRNA are associated with kidney fibrosis, and specific urinary and plasma miRNA profile may have diagnostic and prognostic utility in CKD. | 28077372 |
| Germinoma | Epigenetic Alterations | We showed that pure germinomas are characterized by global low DNA methylation, a unique epigenetic feature making them distinct from all other iGCTs subtypes. | 28078450 |
| Liver carcinoma | Epigenetic Alterations | Serum microRNA panel for early diagnosis of the onset of hepatocellular carcinoma. | 28079796 |
| Hollings Cancer Center | Epigenetic Alterations | In addition, the combination of 3-miRNA panel and AFP was even more effective for discriminating the early stage HCC patients (AUC = 0.988) and low-level AFP HCC patients (AUC = 0.989) from control. | 28079796 |
| Primary malignant neoplasm | Epigenetic Alterations | Unique change of circulating microRNAs (miRNAs) was recognized to occur in early oncogenesis, which conferred it the potential as biomarkers for early detection of cancer. | 28079796 |
| Hollings Cancer Center | Epigenetic Alterations | The selected differentially expressed miRNAs were further verified in 115 HCC patients and 40 health controls by qRT-PCR. | 28079796 |
| Ulcerative Colitis | Epigenetic Alterations | This panel of miRNAs promoter methylation accurately detects UC in urine, comparing well with other promising epigenetic-based biomarkers. | 28081549 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | MicroRNA promoter methylation: a new tool for accurate detection of urothelial carcinoma. | 28081549 |
| Ulcerative Colitis | Epigenetic Alterations | Promoter methylation levels of both microRNAs were significantly higher in UC tissue samples compared with normal urothelium. | 28081549 |
| palladium | Epigenetic Alterations | None of the annotated autosomal genes show changes in DNA methylation between PD individuals and healthy individuals. | 28081695 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Inhibition of Beclin-1-Mediated Autophagy by MicroRNA-17-5p Enhanced the Radiosensitivity of Glioma Cells. | 28081732 |
| Radiation-Induced Cancer, Neoplasms | Epigenetic Alterations | In nude mice, miRNA-17-5p upregulation sensitized the xenograft tumor to irradiation and suppressed irradiation-induced autophagy. | 28081732 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The role of miRNAs in the radiosensitivity of glioma cells and the underlying mechanism is still far from clear. | 28081732 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-92a Promotes Cell Proliferation in Cervical Cancer via Inhibiting p21 Expression and Promoting Cell Cycle Progression. | 28081742 |
| Malignant Neoplasms, cervical cancer | Epigenetic Alterations | MicroRNA-92a (miR-92a) generally plays a promoting role in human cancers, but the underlying mechanism in cervical cancer remains unclear. | 28081742 |
| Malignant Neoplasms, Glioma | Epigenetic Alterations | Abnormal expression of the long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is oncogenic in several human cancers, including gliomas. | 28083786 |
| Primary malignant neoplasm | Epigenetic Alterations | Heterogeneous patterns of DNA methylation-based field effects in histologically normal prostate tissue from cancer patients. | 28084441 |
| Non-Malignant | Epigenetic Alterations | Our results suggest that a novel four-gene signature may be used to increase sensitivity for PC diagnosis through detection of epigenetic field effects in histologically non-malignant prostate tissue samples. | 28084441 |
| SF3B1 wt Allele, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Since small non-coding RNAs (sRNAs), including microRNA (miRNAs), act as regulators of cellular differentiation, we hypothesized that changes to sRNAs might be implicated in the progression of MDS to AML. | 28084850 |
| Bone Marrow | Epigenetic Alterations | We identified five miRNAs that differentiated Groups A and B, independent of bone marrow blast percentage, including three members of the miR-181 family, as well as differential patterns of miRNA isoforms (isomiRs) and tDRs. | 28084850 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Epigenetic Alterations | MicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia. | 28084850 |
| Malignant Neoplasms | Epigenetic Alterations | SRA1, a long non-coding RNA (lncRNA), serves as a critical regulator in several cancers. | 28085012 |
| Papillary thyroid carcinoma | Epigenetic Alterations | Expressions of miRNAs in papillary thyroid carcinoma and their associations with the clinical characteristics of PTC. | 28085013 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNAs (miRNAs) play an important role in cartilage homeostasis, mechanotransduction, and in the pathogenesis of osteoarthritis (OA). | 28085114 |
| Degenerative polyarthritis | Epigenetic Alterations | In conclusion, in OA chondrocytes, HP restores the expression levels of some miRNAs, downregulates MMP-13, ADAMTS-5, and HDAC-4, and modulates the Wnt/b-catenin pathway activation. | 28085114 |
| Different | Epigenetic Alterations | We identified 36 CpG sites with differential loss of DNA methylation and 8 CpG sites with differential gain of DNA methylation, representing 25 genes and 7 genes, respectively. | 28085900 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | Moreover, we showed that the DNA methylation signatures of SLE can be defined in unfractionated white blood cells. | 28085900 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | Our epigenetic findings further support the importance of the type I interferon pathway in SLE pathogenesis. | 28085900 |
| Clinical Coordinator | Epigenetic Alterations | Recently, mechanisms involving noncoding RNAs have been implicated in the development of CRC. | 28086904 |
| Clinical Coordinator, Malignant tumor of colon | Epigenetic Alterations | DNA methylation status can be considered as a useful predictor of survival after CRC surgery, particularly for patients with stage I/II disease or colon cancer. | 28087988 |
| Interstitial tissue of prostate | Epigenetic Alterations | microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma. | 28089917 |
| Myelodysplasia | Epigenetic Alterations | Mutations in genes related to DNA methylation and splicing machinery were found in T-cell samples, which expand at the initial diagnosis of the myelodysplasia, suggesting their importance as early disease events. | 28090092 |
| Prostate Cancer Pathway | Epigenetic Alterations | Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer. | 28091918 |
| MicroRNA 19B | Epigenetic Alterations | The miRNA pair hsa-miR-19b-3p and hsa-miR-297 demonstrated highest sensitivity and specificity. | 28091918 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Expression and prognostic value of microRNAs in lower-grade glioma depends on IDH1/2 status. | 28091987 |
| Intestinal Neoplasms | Epigenetic Alterations | These findings indicate that the miRNA cluster including miR-194 and miR-215 plays important roles in suppressing the growth and attenuating the stemness of intestinal tumor organoids. | 28092415 |
| Intestinal Neoplasms | Epigenetic Alterations | Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids. | 28092415 |
| Intestinal Neoplasms | Epigenetic Alterations | The results of microarray analyses revealed that expression of the cluster miRNAs, miR-194 and miR-215 was markedly suppressed in intestinal tumor organoids in comparison with organoids derived from normal intestinal epithelia. | 28092415 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Here, we valued the expression of ET-1 in CLL, in relation to DNA methylation but also in response to stimulation of some important pathways for the dialogue between CLL and microenvironment. | 28092772 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | The expression of endothelin-1 in chronic lymphocytic leukemia is controlled by epigenetic mechanisms and extracellular stimuli. | 28092772 |
| Sjogrens Syndrome | Epigenetic Alterations | Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjogrens syndrome. | 28093418 |
| Sjogrens Syndrome", Perceived stress scale | Epigenetic Alterations | The aetiology of primary Sjogrens syndrome (pSS), also referred to as autoimmune epithelitis, is incompletely understood but includes an epigenetic contribution. | 28093418 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genetic and Epigenetic Intra-tumour Heterogeneity in Colorectal Cancer. | 28097409 |
| Neoplasms | Epigenetic Alterations | Patients with resected CRC had DNA extracted from eight defined tumour areas which were analysed for two genetic mutations (BRAF and KRAS) and one epigenetic trait (CpG island methylator phenotype/CIMP). | 28097409 |
| Clinical Coordinator | Epigenetic Alterations | Intra-tumoural heterogeneity for both genetic and epigenetic factors in CRC is more prevalent than previously thought in Stage II and Stage III CRC. | 28097409 |
| Clinical Coordinator | Epigenetic Alterations | This study provides new insight into epigenetic heterogeneity of CRC and supports the development of a more targeted biopsy strategy to support expansion of personalised treatment. | 28097409 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-187 promotes growth and metastasis of gastric cancer by inhibiting FOXA2. | 28098868 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) play an active role in the pathogenesis of gastric cancer. | 28098868 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-133b is regulated by TAp63 while no gene mutation is present in colorectal cancer. | 28098895 |
| Clinical Coordinator | Epigenetic Alterations | While the presence of miRNA mutations have frequently been described in CRC, most CRCs do not show any variation in the miR-133b coding sequence. | 28098895 |
| Malignant Neoplasms | Epigenetic Alterations | miRNAs have been reported to be involved in multiple cellular processes and the tumorigenesis of various cancers. | 28098906 |
| Breast Carcinoma | Epigenetic Alterations | In vivo and in vitro effects of microRNA-27a on proliferation, migration and invasion of breast cancer cells through targeting of SFRP1 gene via Wnt/b-catenin signaling pathway. | 28099945 |
| Liver carcinoma | Epigenetic Alterations | High expression of micro RNA-135A in hepatocellular carcinoma is associated with recurrence within 12 months after resection. | 28100188 |
| Hollings Cancer Center | Epigenetic Alterations | If tissue quality permitted, micro RNAs were measured in HCC and liver tissue. | 28100188 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | DNMT3A is a recurrently mutated epigenetic modifier gene in AML. | 28100593 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small non-coding RNAs composed of 18-25 nucleotides that can post-transcriptionally regulate gene expression and have key regulatory roles in cancer, acting as both oncogenes and tumor suppressors. | 28101798 |
| Breast Carcinoma | Epigenetic Alterations | These two miRNAs, miR-10b and miR-153 were significantly associated to lymph node metastases occurrence in triple negative breast carcinoma. | 28101798 |
| Bicuspid aortic valve | Epigenetic Alterations | Patients with bicuspid and tricuspid aortic valve exhibit distinct regional microrna signatures in mildly dilated ascending aorta. | 28102444 |
| Bicuspid aortic valve | Epigenetic Alterations | We focused on microRNAs as potential contributors to the pathogenesis of ascending aorta (AA) dilatation in patients with stenotic tricuspid (TAV) or bicuspid aortic valve (BAV). | 28102444 |
| Cardiovascular Diseases | Epigenetic Alterations | Aortic RNA was analyzed through PCR arrays, profiling the expression of 84 microRNAs involved in cardiovascular disease. | 28102444 |
| Cerebral Convexity | Epigenetic Alterations | Distinct signatures of differentially expressed microRNAs are evident in TAV and BAV patients vs. donors, as well as differences between aortic concavity and convexity in patients only. | 28102444 |
| Takayasu Arteritis | Epigenetic Alterations | MicroRNAs could play distinct roles in BAV and TAV aortopathy, with possible implications in diagnosis and therapy. | 28102444 |
| Nasopharyngeal carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-101 inhibits invasion and angiogenesis through targeting ITGA3 and its systemic delivery inhibits lung metastasis in nasopharyngeal carcinoma. | 28102841 |
| Metastasis | Epigenetic Alterations | Our study elucidates the molecular mechanisms of miR-101/ITGA3 pathway in regulating NPC metastasis and angiogenesis, and the systemic delivery of miR-101 provides a potent evidence for the development of a novel microRNA-targeting anticancer strategy for NPC patients. | 28102841 |
| Lung Diseases, Interstitial, Rheumatoid Arthritis | Epigenetic Alterations | Plasma miRNA expression profiles in rheumatoid arthritis associated interstitial lung disease. | 28103855 |
| Right arm | Epigenetic Alterations | Sixteen selected miRNA levels were analyzed in individual plasmas from 64 RA patients with or without RA-ILD. | 28103855 |
| Lung Diseases, Interstitial, Right arm | Epigenetic Alterations | The values of miRNA index (214, 7) generated from hsa-miR-214-5p and hsa-miR-7-5p for ILD were significantly elevated in RA patients with RA-ILD compared with those without (0.122 +- 0.332 in RA with ILD, 0.006 +- 0.013 in RA without ILD, P = 0.0010). | 28103855 |
| Stomach Neoplasms | Epigenetic Alterations | Epigenetic regulation of Wnt/b-catenin signal-associated genes in gastric neoplasia of the fundic gland (chief cell-predominant) type. | 28105693 |
| Malignant Neoplasms, Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) are small, non-coding RNAs that play important roles in the carcinogenesis and progression of cancers. | 28106539 |
| Neoplasms | Epigenetic Alterations | Aberrant expression of miRNAs in tissue and plasma has been found in various solid tumors. | 28106539 |
| Primary malignant neoplasm | Epigenetic Alterations | We explored the use of a novel RNA-interference method for a driver oncogene regulating cancer specific energy metabolism by the combination treatment with a small interfering RNA (siRNA) and a microRNA. | 28106737 |
| Malignant Neoplasms, Carcinogenesis, Malignant neoplasm of urinary bladder | Epigenetic Alterations | miRNAs play a key role in the carcinogenesis of many cancers, including bladder cancer. | 28109084 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Long intergenic non-coding RNA 00152 promotes lung adenocarcinoma proliferation via interacting with EZH2 and repressing IL24 expression. | 28109288 |
| Primary malignant neoplasm | Epigenetic Alterations | Numerous studies have shown that long non-coding RNAs (lncRNAs) behave as a novel class of transcript during multiple cancer processes, such as cell proliferation, apoptosis, migration, and invasion. | 28109288 |
| Cerebrovascular accident | Epigenetic Alterations | The Diagnostic Value of Serum miRNA-221-3p, miRNA-382-5p, and miRNA-4271 in Ischemic Stroke. | 28111007 |
| Cerebrovascular accident, Ischemic stroke | Epigenetic Alterations | Circulating serum miRNA-221-3p and miRNA-382-5p levels were significantly lower in patients with ischemic stroke compared to healthy control subjects, whereas there was no significant difference in the serum levels of miRNA-4271 between the stroke patients and healthy controls (P > .05). | 28111007 |
| Ischemic stroke | Epigenetic Alterations | ROC curves revealed the areas under the curve for circulating miRNA-221-3p, miRNA-382-5p, and miRNA-4271 to be .8106, .7483, and .6317 in ischemic stroke patients compared with healthy volunteers, respectively. | 28111007 |
| Ischemic stroke | Epigenetic Alterations | Our findings suggest that serum circulating miRNA-221-3p and miRNA-382-5p might be used as potential noninvasive biomarkers for the diagnosis of ischemic stroke. | 28111007 |
| Arteriosclerosis | Epigenetic Alterations | Epigenetic modulation by histone acetyltransferase (HAT) plays a critical role in osteogenic transdifferentiation and atherosclerosis. | 28111052 |
| Carcinoma, Lobular, Ductal Carcinoma | Epigenetic Alterations | Expression of DNA methylation-related proteins in invasive lobular carcinoma of breast: comparison to invasive ductal carcinoma. | 28111737 |
| cervical cancer | Epigenetic Alterations | MicroRNA-145 inhibits tumorigenesis and invasion of cervical cancer stem cells. | 28112371 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-200c binding to FN1 suppresses the proliferation, migration and invasion of gastric cancer cells. | 28113080 |
| Adenocarcinoma, Neoplasms | Epigenetic Alterations | Preoperative radiological findings, serum CEA level, serum microRNA-183 (miR-183) level, and tumour size differed significantly between patients with adenocarcinoma in situ (AIS) or minimally invasive adenocarcinoma (MIA) and those with invasive adenocarcinoma (IAC). | 28115792 |
| Malignant Neoplasms, Urinary Bladder, Stomach Carcinoma | Epigenetic Alterations | Global measures of peripheral blood DNA methylation have been associated with risk of some malignancies, including breast, bladder, and gastric cancer. | 28116812 |
| Prostate Cancer Pathway | Epigenetic Alterations | We used conditional logistic regression to test for associations between genome-wide measures of DNA methylation and risk of prostate cancer and its subtypes, and by time between blood draw and diagnosis. | 28116812 |
| Prostate Cancer Pathway, Aggressive behavior | Epigenetic Alterations | We observed no associations between the genome-wide measure of DNA methylation based on all CpG sites and risk of prostate cancer or aggressive disease. | 28116812 |
| Craniocerebral Trauma, Amnesia, CTCAE, Post-Concussion Syndrome | Epigenetic Alterations | Two micro-RNAs, mir142-3p and mir423-3p demonstrated potential clinical utility differentiating patients after mild head injury into those at greater risk of developing amnesia and therefore, post-concussive syndromes. | 28117263 |
| Cardiovascular Diseases, Atrial Fibrillation | Epigenetic Alterations | MicroRNAs (miRNAs) are emerging as key regulators of complex biological processes in several cardiovascular diseases, including atrial fibrillation (AF). | 28117343 |
| Neoplasms | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) are emerging as key regulators in tumor development. | 28119088 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Recent evidence has highlighted the key regulatory roles of long non-coding RNAs (lncRNAs) in tumor development and progression including gastric cancer (GC).The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been identified as an oncogene in some tumors. | 28122299 |
| Stomach Carcinoma | Epigenetic Alterations | The long noncoding RNA PVT1 functions as a competing endogenous RNA by sponging miR-186 in gastric cancer. | 28122299 |
| Penis carcinoma | Epigenetic Alterations | Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact. | 28122331 |
| Epstein-Barr virus associated gastric carcinoma | Epigenetic Alterations | High level of viral microRNA-BART20-5p expression is associated with worse survival of patients with Epstein-Barr virus-associated gastric cancer. | 28122341 |
| Neoplasms | Epigenetic Alterations | The expression of all three analyzed EBV microRNAs was significantly higher in the tumor tissue than in the paired normal tissue (P < 0.001 for each). | 28122341 |
| Glioma | Epigenetic Alterations | Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome. | 28122345 |
| Diabetic Retinopathy | Epigenetic Alterations | Effects of miRNA-200b on the development of diabetic retinopathy by targeting VEGFA gene. | 28122882 |
| Obesity, Complication Aspects | Epigenetic Alterations | DNA methylation plays an important role in obesity and related metabolic complications. | 28123940 |
| Obesity | Epigenetic Alterations | Taken together, our data show distinct tissue specific epigenetic alterations which associate with obesity. | 28123940 |
| Stomach Carcinoma | Epigenetic Alterations | Clinical significance of the long noncoding RNA RP11-19P22.6-001 in gastric cancer. | 28128738 |
| Stomach Carcinoma | Epigenetic Alterations | To explore the diagnostic value of the long noncoding RNA RP11-19P22.6-001 in gastric cancer. | 28128738 |
| Carcinogenesis, Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) play roles in carcinogenesis; however, the significance of most lncRNAs in gastric cancer is unclear. | 28128738 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-21 contributes to the discrimination of chemoresistance in metastatic gastric cancer. | 28128744 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Aberrant MicroRNA Expression in Patients With Endometrial Cancer. | 28129244 |
| Stomach Carcinoma | Epigenetic Alterations | Epigenetic alterations of gastrokine 1 gene expression in gastric cancer. | 28129645 |
| Stomach Carcinoma, Stomach Neoplasms | Epigenetic Alterations | GKN1 down-regulation in gastric cancer tissues was shown to be associated with high levels of H3K9triMe and with the recruitment of SUV39H1 to the GKN1 promoter, suggesting the presence of an epigenetic transcriptional complex that negatively regulates GKN1 expression in gastric tumors. | 28129645 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Gene expression from whole transcriptome sequencing (WTS) and miRNA profiling were performed using fresh-frozen, quadruple WT GIST tissue specimens and compared with SDH and KIT/PDGFRA-mutant GIST. | 28130400 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | A total of 247 mRNA transcripts and 66 miRNAs were differentially expressed specifically in quadruple WT GIST. | 28130400 |
| MYELODYSPLASTIC SYNDROME | Epigenetic Alterations | Mechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes. | 28130497 |
| Colorectal Neoplasms | Epigenetic Alterations | Although, initial YAP activation, which stimulates IL6ST gene transcription, may be caused by reduced serine phosphorylation, sustained YAP activation depends on tyrosine phosphorylation by SFKs, whose inhibition, along with STAT3-activating JAK kinases, causes regression of established colorectal tumors. | 28130546 |
| Meningioma | Epigenetic Alterations | Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma. | 28130639 |
| Medial collateral ligament | Epigenetic Alterations | We suggest that, in the absence of the typical CCND1/IGH@ fusion, this rearrangement promotes MCL pathogenesis by eliminating miRNA interaction elements within the 3-UTR of the CCND1 mRNA transcript consequently resulting in CCND1 overexpression. | 28132860 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers. | 28135856 |
| Malignant Neoplasms | Epigenetic Alterations | Background: MicroRNAs (miRNAs) mediate negative regulation of target genes through base pairing, and aberrant miRNA expression has been described in cancers. | 28138309 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We hypothesized that single nucleotide polymorphisms (SNPs) within miRNA target sites might influence clinical outcomes in patients with colorectal cancer. | 28138309 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Conclusion: Our results suggest that the genetic interaction profiles among SNPs within miRNA target sites might be prognostic markers for colorectal cancer survival. | 28138309 |
| Degenerative polyarthritis | Epigenetic Alterations | In conclusion, our findings reveal an miRNA functional pathway important for OA development. | 28139355 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNAs (miRNAs) are emerging as important regulators in osteoarthritis (OA) pathogenesis. | 28139355 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | PCa diagnosis and prognostication might be perfected using epigenetic biomarkers, among which aberrant DNA methylation of microRNA promoters has not been systematically explored. | 28143614 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Herein, we identified aberrantly methylated microRNAs promoters in PCa and assessed its diagnostic and prognostic biomarker potential. | 28143614 |
| Primary malignant neoplasm | Epigenetic Alterations | Studies suggest that miRNAs play an important role in cancer; however, their role in HPV-mediated oncogenesis remains largely unknown. | 28143871 |
| Neoplasms | Epigenetic Alterations | Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC. | 28146432 |
| Myocardial dysfunction, Septicemia | Epigenetic Alterations | MicroRNA-135a is up-regulated and aggravates myocardial depression in sepsis via regulating p38 MAPK/NF-kB pathway. | 28147298 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-135a (miR-135a) is implicated in the pathological processes of several cancers. | 28147298 |
| Lymphoma, Large-Cell, Follicular | Epigenetic Alterations | Our data demonstrated that the expression of miRNA-155 was upregulated in newly diagnosed B-cell NHL patients. | 28148469 |
| Diffuse Large B-Cell Lymphoma, Lymphoma, Large-Cell, Follicular | Epigenetic Alterations | Despite contradicting literature reports, the current findings suggest the potential value of miRNA-155 as a biomarker of prognosis and monitoring in B-cell NHL, and especially that of the DLBCL type. | 28148469 |
| Pancreatic Neoplasm, SpecimenType - Cyst, Dysplasia | Epigenetic Alterations | Predicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers. | 28148542 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | microRNA-577 suppresses tumor growth and enhances chemosensitivity in colorectal cancer. | 28150434 |
| Stenosis, Pulmonary Vein | Epigenetic Alterations | The lack of concordance in twins suggests epigenetic or environmental factors may play a role in the development of pulmonary vein stenosis. | 28152279 |
| Malignant neoplasm of breast | Epigenetic Alterations | A reduced expression of Bin1 caused by DNA methylation, has been reported in breast and prostate cancers. | 28152502 |
| Malignant neoplasm of larynx | Epigenetic Alterations | Evaluation of polymorphisms in microRNA biosynthesis genes and risk of laryngeal cancer in the Polish population. | 28155978 |
| Primary malignant neoplasm | Epigenetic Alterations | The role of micro RNAs in cancer development is also considerable. | 28155978 |
| Heart failure | Epigenetic Alterations | Increased BACE1-AS long noncoding RNA and b-amyloid levels in heart failure. | 28158647 |
| Heart failure | Epigenetic Alterations | Antisense long noncoding RNAs (ncRNAs) are transcripts emerging from the opposite strand of a coding-RNA region and their role in heart failure (HF) is largely unknown. | 28158647 |
| Hollings Cancer Center | Epigenetic Alterations | We assessed mRNA and microRNA (miRNA) expression profiles in primary human hepatocytes, liver biopsies and resections of patients with HCC, and analysed microarray and RNA-seq data from paired liver biopsies of patients with HCC. | 28159835 |
| Malignant Neoplasms, Squamous cell carcinoma of the head and neck, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | The emerging evidence showed that long noncoding RNAs (lncRNAs) are involved in cell growth and apoptosis as well as cancer progression and metastasis of malignant tumor, however, limited data are available on the role of lncRNAs in human papillomavirus (HPV)-associated Head and neck squamous cell carcinomas (HNSCC). | 28159935 |
| Malignant neoplasm of kidney | Epigenetic Alterations | It is well known that abnormal DNA methylations occur frequently in kidney cancer. | 28160561 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | We extracted extracellular vesicles from urine of urothelial carcinoma patients and the control group to identify cancer-specific microRNAs in urinary extracellular vesicles as new biomarkers. | 28160564 |
| Carcinoma, Transitional Cell | Epigenetic Alterations | From the microarray results 5 microRNAs overexpressed in urinary extracellular vesicles of urothelial carcinoma patients were identified. | 28160564 |
| Multiple Myeloma | Epigenetic Alterations | Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myeloma. | 28164410 |
| Primary malignant neoplasm | Epigenetic Alterations | Significance of Serum MicroRNAs in the Auxiliary Diagnosis of Non-Small Cell Lung Cancer. | 28164492 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Area under the curves (AUCs) of serum miR-22, miR-125b, and miR-15b in the diagnosis of NSCLC were 0.725, 0.704, and 0.619, respectively, and the diagnostic significance of these three serum miRNAs for NSCLC was higher than that of serum CEA (AUC = 0.594). | 28164492 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Serum miRNAs have potential as NSCLC-screening tumor markers, and serum miR-22 and miR15b might be used as reference indexes for the early diagnosis of NSCLC in the future. | 28164492 |
| Cardiovascular Diseases | Epigenetic Alterations | MicroRNAs are present in human plasma and have been reported to be biomarkers for cardiovascular diseases. | 28164501 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Promoter methylation of tumor suppressor genes is an important epigenetic alteration that occurs in the primary stages of human tumors, including breast cancer. | 28164568 |
| ovarian neoplasm, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Our results therefore demonstrate cancer epigenetics induces a loop of cancer-stroma-cancer interaction in omental microenvironment that promotes peritoneal metastasis of ovarian cancer cells via TNFa-TGFa-EGFR. | 28166193 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. | 28167280 |
| Ischemic stroke | Epigenetic Alterations | Epigenetic modification may play an important role in pathophysiology of ischemic stroke (IS) risk. | 28168424 |
| Fragile X Syndrome | Epigenetic Alterations | This FMR1 5hmC enrichment was not present in cellular models of FXS including fibroblasts, lymphocytes and reprogrammed neurons, indicating they do not fully recapitulate this epigenetic feature of disease. | 28173181 |
| Stomach Carcinoma | Epigenetic Alterations | Hypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer. | 28173803 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) act as post-transcriptional regulators of gene expression and modulate the tumorigenesis, including gastric cancer. | 28173803 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | In vivo experiments validated the in vitro results.Results: Our data identified a four-miRNA signature that classified HNSCC patients at high- or low-risk of recurrence. | 28174235 |
| Squamous cell carcinoma | Epigenetic Alterations | Genome-wide DNA methylation profile identified a unique set of differentially methylated immune genes in oral squamous cell carcinoma patients in India. | 28174608 |
| Malignant Neoplasms | Epigenetic Alterations | Epigenetic changes, mainly the altered DNA methylation, have been implicated in many cancers. | 28174608 |
| SERPINB3 wt Allele | Epigenetic Alterations | Genome-wide DNA methylation analysis identified several novel differentially methylated regions associated with OSCC. | 28174608 |
| SERPINB3 wt Allele | Epigenetic Alterations | Distinct epigenetic drifts for hypo- and hypermethylation across CpG islands suggested independent mechanisms of hypo- and hypermethylation in OSCC development. | 28174608 |
| Alzheimers Disease | Epigenetic Alterations | GSK3b 5-flanking DNA Methylation and Expression in Alzheimers Disease Patients. | 28176663 |
| Concomitant Medication Submission Domain | Epigenetic Alterations | We identified mRNA and miRNA signatures of individual CM traits and their clustering. | 28178938 |
| Concomitant Medication Submission Domain | Epigenetic Alterations | We identified hundreds of significant associations between mRNAs, miRNAs, and individual CM traits. | 28178938 |
| Concomitant Medication Submission Domain | Epigenetic Alterations | Four mRNAs (FAM13A, CSF2RB, HIST1H2AC, WNK1) were associated with all 6 CM traits (FDR < 0.001) and four miRNAs (miR-197-3p, miR-328, miR-505-5p, miR-145-5p) were associated with four CM traits (FDR < 0.05). | 28178938 |
| Breast Carcinoma, Mammary Neoplasms | Epigenetic Alterations | DNA Methylation in Breast Tumor from High-risk Women in the Breast Cancer Family Registry. | 28179314 |
| Alzheimers Disease | Epigenetic Alterations | Profile of 6 microRNA in blood plasma distinguish early stage Alzheimers disease patients from non-demented subjects. | 28179587 |
| Admitting diagnosis | Epigenetic Alterations | We confirmed 23 miRNAs reported earlier as AD biomarker candidates in blood and found 26 novel differential miRNAs between AD and control subjects. | 28179587 |
| palladium, Depression, CTCAE | Epigenetic Alterations | We further described the relationship between these miRNAs and PD with depression (PD-Dep). | 28181066 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNAs miR-7 and miR-340 predict response to neoadjuvant chemotherapy in breast cancer. | 28181130 |
| Breast Carcinoma | Epigenetic Alterations | miRNAs have been linked to chemosensitivity of breast cancer cells in vitro. | 28181130 |
| Neoplasms | Epigenetic Alterations | Relative expression of 10 miRNAs likely to be associated with chemotherapy response (miR-7,-21,-29a,-29b,-34a,-125b,-155,-200c,-340,-451) was determined by quantitative RT-PCR from pretherapeutic biopsies (n = 64) and residual invasive tumor after chemotherapy (n = 42). | 28181130 |
| Obesity | Epigenetic Alterations | Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. | 28181167 |
| Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Epigenetic mechanisms such as microRNAs (miRs) and DNA methylation may contribute to complications of type 2 diabetes mellitus. | 28185533 |
| PRKAR1A gene, MEN1 wt Allele | Epigenetic Alterations | Mutations in MEN1, PRKAR1A, and DNMT3A in Spitzoid melanomas may indicate involvement of the protein kinase A pathway, or a role of DNA methylation in the disease. | 28186096 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-196b is an independent prognostic biomarker in patients with pancreatic cancer. | 28186267 |
| Endometrial Stromal Tumors | Epigenetic Alterations | In this report, we hypothesized that micro-RNA(miR)-1 regulates IL11 and that IL11 promotes high grade endometrial tumour growth. | 28186993 |
| Adenocarcinoma of large intestine | Epigenetic Alterations | Growing evidence has shown that long non-coding RNAs (lncRNAs) can serve as prospective markers for survival in patients with colorectal adenocarcinoma. | 28187432 |
| Prostate Cancer Pathway | Epigenetic Alterations | A potential panel of four-long noncoding RNA signature in prostate cancer predicts biochemical recurrence-free survival and disease-free survival. | 28188414 |
| Neoplasms | Epigenetic Alterations | Emerging evidence has shown that microRNAs (miRNAs) play important roles in tumor development and progression. | 28189678 |
| Clinical Coordinator | Epigenetic Alterations | MicroRNAs are small non-coding RNA molecules whose expression pattern can be altered in various diseases such as CRC. | 28193082 |
| Clinical Coordinator | Epigenetic Alterations | We found that the expression levels of miR-4478 and miR-1295b-3p (two previously down-regulated fecal miRNAs) were significantly decreased in FFPE samples of CRC patients compared to healthy controls. | 28193082 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. | 28193514 |
| Colorectal Cancer Pathway, ibudilast, Inflammatory Bowel Diseases | Epigenetic Alterations | Intestinal tissues from patients with inflammatory bowel disease (IBD) and colorectal cancer have increased expression of microRNA-301a (MIR301A) compared with tissues from patients without IBD. | 28193514 |
| Neoplasms | Epigenetic Alterations | Methylation accumulates during aging in a subset of molecules, suggesting that the epigenetic landscape within a founder-cell population may contribute to tumor formation. | 28193856 |
| Autoimmune thyroid disease | Epigenetic Alterations | Intraindividual variation of microRNA expression levels in plasma and peripheral blood mononuclear cells and the associations of these levels with the pathogenesis of autoimmune thyroid diseases. | 28195542 |
| Hashimoto Disease, Graves Disease, Hodgkin Disease | Epigenetic Alterations | We also analysed the expression levels of two of these miRNAs (miR-146a and miR-155) in 20 healthy controls, 60 Graves disease (GD) patients and 50 Hashimotos disease (HD) patients. | 28195542 |
| Depressive disorder | Epigenetic Alterations | Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder. | 28198448 |
| Minimal Disseminated Disease | Epigenetic Alterations | One hundred and fourteen patients with MDD and eighty-eight healthy controls underwent T1-weighted structural magnetic resonance imaging and FKBP5 rs1360780 genotyping, including DNA methylation of intron 7. | 28198448 |
| Minimal Disseminated Disease | Epigenetic Alterations | Our findings suggest that the FKBP5 gene and its epigenetic changes could have influence on morphologic changes of several brain regions involved in emotion regulation, and that this process may be associated with the development of MDD. | 28198448 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA-148a serves as a prognostic factor and suppresses migration and invasion through Wnt1 in non-small cell lung cancer. | 28199399 |
| Carcinoma of lung, Cancer-Related Death, Primary malignant neoplasm | Epigenetic Alterations | Lung cancer is the leading cause of cancer death in the world, and aberrant expression of miRNA is a common feature during the cancer initiation and development. | 28199399 |
| Primary malignant neoplasm | Epigenetic Alterations | Our results showed that there were 86 of 159 patients with low miRNA-148a expression and miRNA-148a was significantly down-regulated in primary cancer tissues when compared with their adjacent normal lung tissues. | 28199399 |
| Cancer Pain, Metastasis, Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Low expression of miRNA-148a was strongly associated with high tumor grade, lymph node (LN) metastasis and a higher risk of tumor-related death in NSCLC. | 28199399 |
| Primary malignant neoplasm | Epigenetic Alterations | Our data showed that the Wnt1 expression was negatively correlated with the expression of miRNA-148a in both primary cancer tissues and their corresponding adjacent normal lung tissues. | 28199399 |
| Primary malignant neoplasm | Epigenetic Alterations | In addition, overexpression of miRNA-148a inhibited Wnt1 protein expression in cancer cells. | 28199399 |
| Carcinoma of lung | Epigenetic Alterations | And knocking down of Wnt-1 by siRNA had the similar effect of miRNA-148a overexpression on cell migration and invasion in lung cancer cells. | 28199399 |
| Secondary malignant neoplasm of lung | Epigenetic Alterations | In conclusion, our results suggest that miRNA-148a inhibited cell migration and invasion through targeting Wnt1 and this might provide a new insight into the molecular mechanisms of lung cancer metastasis. | 28199399 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | These phenomena were compared with epigenetic mechanisms involved in metastasis, as parallel processes of community (biological invasion) and organism (cancer) invasions. | 28205577 |
| Low Back Pain | Epigenetic Alterations | A prospective evaluation of microRNA (miRNA) expression in patients with chronic low back pain (CLBP). | 28207662 |
| Feel Pain | Epigenetic Alterations | miRNAs are known to be important mediators of gene regulation in various processes, including pathophysiology of pain. | 28207662 |
| Clinical Coordinator | Epigenetic Alterations | The expression of miR-296 was confirmed by qRT-PCR in CRC tissues and cells, and its level was altered by corresponding miRNA vectors. | 28209128 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Dysregulation of microRNAs (miRNAs) is actively involved in the pathogenesis and tumorigenicity of colorectal cancer (CRC). | 28209128 |
| Lymphoma, Non-Hodgkin | Epigenetic Alterations | Plasma DNA methylation of p16 and shp1 in patients with B cell non-Hodgkin lymphoma. | 28210822 |
| Fibrosis Assessment | Epigenetic Alterations | Liver fibrosis is influenced by patients genomics, including IFNL3 genotype and microRNA expression. | 28211229 |
| Fibrosis Assessment | Epigenetic Alterations | Serum microRNAs as predictors for liver fibrosis staging in hepatitis C virus-associated chronic liver disease patients. | 28211229 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA PTENP1 functions as a ceRNA to modulate PTEN level by decoying miR-106b and miR-93 in gastric cancer. | 28212532 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | Long non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, has been reported to exert its tumor suppressive function via modulation of PTEN expression in many malignancies. | 28212532 |
| Stomach Carcinoma | Epigenetic Alterations | However, whether a PTENP1~miRNA~PTEN ceRNA network exists and how it functions in gastric cancer (GC) remains elusive. | 28212532 |
| Neoplasms | Epigenetic Alterations | Thus, we revealed a tumor suppressive role of PTENP1 as ceRNA in GC and pinpointed the specific miRNAs decoyed by PTENP1, highlighting the emerging roles of ceRNAs in the biological regulation of GC cells and their possible clinical significance. | 28212532 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Urinary cell microRNA-based prognostic classifier for non-muscle invasive bladder cancer. | 28212556 |
| Neoplasms | Epigenetic Alterations | The risk score derived from the model containing these two microRNAs was able to discriminate between two groups with a highly significant different probability of tumour progression (HR, 5.204; p<0.001) which was maintained when patients were stratified according to tumour risk. | 28212556 |
| Multiple Myeloma | Epigenetic Alterations | Prognostic role of circulating exosomal miRNAs in multiple myeloma. | 28213378 |
| Cardiovascular Diseases | Epigenetic Alterations | We report novel associations of DNA methylation with lipid levels, describe epigenetic mechanisms related to previous genome-wide association studies discoveries, and provide evidence implicating epigenetic regulation of reverse cholesterol transport in blood in relation to occurrence of cardiovascular disease events. | 28213390 |
| Coronary Artery Disease | Epigenetic Alterations | Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies. | 28213390 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Implication of downregulation and prospective pathway signaling of microRNA-375 in lung squamous cell carcinoma. | 28214218 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The Novel Long Noncoding RNA TUSC7 Inhibits Proliferation by Sponging MiR-211 in Colorectal Cancer. | 28214867 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | The novel long noncoding RNA (lncRNA) tumor suppressor candidate 7 (TUSC7) has been reported as a potential tumor suppressor, while the functional role of TUSC7 is still unknown in colorectal cancer (CRC). | 28214867 |
| Intracranial Aneurysm | Epigenetic Alterations | Our previous microarray results identified numerous microRNAs (miRNAs), including miR-29b, that were differentially expressed in the serum of intracranial aneurysm (IA) patients. | 28214880 |
| Clinical Coordinator | Epigenetic Alterations | Taken together, the findings of our study demonstrate that miR-506 overexpression in HCT116-OxR cells enhances oxaliplatin sensitivity by inhibiting MDR1/P-gp expression via down-regulation of the Wnt/b-catenin pathway and thus provide a rationale for the development of miRNA-based strategies to reverse oxaliplatin resistance in CRC cells. | 28217977 |
| Childhood Leukemia | Epigenetic Alterations | Our results suggest that leukemia microvesicles are able to induce some effects on healthy hematopoietic stem cells such as promoting cell survival and some microRNAs deregulation, while stemness is maintained. | 28218044 |
| Liver carcinoma | Epigenetic Alterations | MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5. | 28218742 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Identification of miRNAs related to metastasis enables us to obtain better insight into cancer development. | 28218742 |
| Liver carcinoma | Epigenetic Alterations | Altogether, our data indicate that the levels of these miRNAs may be used as biological markers for evaluating hepatocellular carcinoma progression. | 28218742 |
| prostatitis, Erectile dysfunction | Epigenetic Alterations | A Variant in the Precursor of MicroRNA-146a is Responsible for Development of Erectile Dysfunction in Patients with Chronic Prostatitis via Targeting NOS1. | 28218896 |
| Degenerative polyarthritis | Epigenetic Alterations | Clarifying epigenetic mechanisms of 5hmC induced by TWIST1 is a critical molecule to understanding OA pathogenesis. | 28220902 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Aberrant DNA methylation is known to occur in patients with acute myeloid leukemia (AML), whereas methylation signatures and prognostic markers have been proposed. | 28222251 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion. | 28222670 |
| Breast Carcinoma | Epigenetic Alterations | Mechanisms underlying the inverse association between physical activity and survival after breast cancer are unresolved, but DNA methylation may play a role. | 28222775 |
| Parkinson Disease | Epigenetic Alterations | MicroRNA biomarkers of Parkinsons disease in serum exosome-like microvesicles. | 28223160 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | miRNAs function as tumor suppressors and oncogenes in various cancers and regulate the differentiation potential of hematopoietic stem and progenitor cells (HSPCs). | 28224273 |
| SF3B1 wt Allele | Epigenetic Alterations | It has been suggested that miRNAs may play an important role in progression of MDS. | 28224273 |
| Herpes zoster disease, Postherpetic neuralgia | Epigenetic Alterations | Comparing serum microRNA levels of acute herpes zoster patients with those of postherpetic neuralgia patients. | 28225487 |
| Malignant - descriptor | Epigenetic Alterations | Aberrant expression of the microRNA miR-122 has frequently been reported in malignant cancers. | 28231730 |
| Stomach Carcinoma | Epigenetic Alterations | It is necessary to uncover the detailed pattern of whole genome-wide abnormal DNA methylation during the development of gastric cancer (GC). | 28231797 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Long non-coding RNA LINC00672 contributes to p53 protein-mediated gene suppression and promotes endometrial cancer chemosensitivity. | 28232485 |
| Prostate carcinoma | Epigenetic Alterations | Further TSPYL5 gene and protein expression in prostate carcinoma cells and diseased tissues including its susceptibility for epigenetic silencing is unknown. | 28235398 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Epigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance. | 28235630 |
| Degenerative polyarthritis | Epigenetic Alterations | Accumulating evidence suggests that microRNAs (miRNAs) are associated with OA, but little is known of their function in chondrocyte ECM degradation. | 28236026 |
| ovarian neoplasm | Epigenetic Alterations | DNA methylation is well-known to be associated with ovarian cancer (OC) and has great potential to serve as a biomarker in monitoring response to therapy and for disease screening. | 28241454 |
| cervical cancer | Epigenetic Alterations | A panel of patients with cervical cancer was selected and the importance of the histone modifications concerning survival-time (overall survival and relapse-free survival) was analyzed in 250 cases. | 28241481 |
| cervical cancer, Primary malignant neoplasm | Epigenetic Alterations | Although cervical cancer is the fourth most common cancer in women worldwide, a systematic study about the prognostic value of specific changes in the chromatin structure, such as histone acetylation or histone methylation, is missing. | 28241481 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | The expression pattern and biological role of long non-coding RNA (lncRNA) in cancer has been reported to be involved in many cancers. | 28245089 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers. | 28245474 |
| Breast Carcinoma | Epigenetic Alterations | Prognostic significance of long noncoding RNA Z38 as a candidate biomarker in breast cancer. | 28247935 |
| Breast Carcinoma | Epigenetic Alterations | Long noncoding RNA (lncRNA) Z38 has been shown to promote cell proliferation and tumorigenesis in breast cancer. | 28247935 |
| Glioblastoma Multiforme | Epigenetic Alterations | A three-microRNA signature identifies two subtypes of glioblastoma patients with different clinical outcomes. | 28248456 |
| Primary malignant neoplasm | Epigenetic Alterations | By a combined inferential strategy on PCA results, we identified a reduced set of three miRNAs - miR-23a, miR-27a, and miR-9* (miR-9-3p) - able to discriminate the proneural- and mesenchymal-like GSC phenotypes as well as mesenchymal and proneural subtypes of primary GBM included in The Cancer Genome Atlas (TCGA) data set. | 28248456 |
| Ischemic stroke, Ischemic | Epigenetic Alterations | Distinctive expression signatures of serum microRNAs in ischaemic stroke and transient ischaemic attack patients. | 28251236 |
| Ischemic stroke | Epigenetic Alterations | Circulating microRNAs (miRNAs) have recently emerged as promising biomarkers for ischaemic stroke (IS). | 28251236 |
| Transient Ischemic Attack | Epigenetic Alterations | Markedly altered miRNAs were subsequently validated by individual quantitative reverse-transcription PCR (qRT-PCR) assays first in the same cohort of TLDA and further confirmed in another larger cohort including 177 IS, 81 TIA patients and 42 controls. | 28251236 |
| Cerebrovascular accident, Transient Ischemic Attack, Neurologic Deficits | Epigenetic Alterations | Logistic regression and receiver-operating characteristic curve analyses demonstrated that these altered miRNAs may function as predictive and discriminative biomarkers for IS and TIA, and their distinctive expression signatures may contribute to assessing neurological deficit severity of IS and subsequent stroke risk after TIA. | 28251236 |
| Admitting diagnosis, "Alzheimers Disease", Neurodegenerative Disorders | Epigenetic Alterations | Aberrant DNA methylation has been observed in the patients with Alzheimers disease (AD), a common neurodegenerative disorder in the elderly. | 28253273 |
| Carcinoma of lung, Metastasis, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Recently studies have demonstrated that the long non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) may participate in the development and progression of lung cancer. | 28253859 |
| Paraganglioma | Epigenetic Alterations | Genetic and epigenetic patterns in patients with the head-and-neck paragangliomas associate with differential clinical characteristics. | 28255624 |
| Drug-Induced Liver Disease | Epigenetic Alterations | Liver-enriched microRNA-122 (miR-122) is a novel circulating biomarker for drug-induced liver injury (DILI). | 28257154 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, DNA methylation-based marker of ageing, known as epigenetic clock, has been linked with cancer risk factors. | 28259012 |
| Postmenopausal state | Epigenetic Alterations | DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility. | 28259012 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic age acceleration and CpG island methylation have a weak, but statistically significant, association with breast cancer susceptibility. | 28259012 |
| Heart failure | Epigenetic Alterations | Circulating microRNAs (miRs) are promising biomarkers for heart failure (HF). | 28259597 |
| Hollings Cancer Center, Liver carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic disruption of tumor suppressor genes (TSGs), particularly DNA methylation, plays a key role in hepatocellular carcinoma (HCC) pathogenesis. | 28259820 |
| Hollings Cancer Center | Epigenetic Alterations | Thus, epigenetic suppression of BCLB expression is involved in HCC development, which might have therapeutic implications for HCC patients. | 28259820 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Identification of the long non-coding RNA LET as a novel tumor suppressor in gastric cancer. | 28260083 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNA-9 (miR-9) has been confirmed to be dysregulated in many types of cancers. | 28260112 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant expression of microRNAs (miRNAs) plays an important role in the MDR of various types of cancers. | 28260112 |
| Malignant Neoplasms, Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | The deregulation of microRNA (miRNA) is frequently associated with a variety of cancers, including hepatocellular carcinoma (HCC). | 28261837 |
| Hollings Cancer Center | Epigenetic Alterations | Therefore, miR-199a-5p may serve as a useful therapeutic agent for miRNA-based HCC therapy. | 28261837 |
| Malignant Neoplasms, Clinical Coordinator, Metastasis | Epigenetic Alterations | Although microRNAs (miRNAs) are a class of small noncoding RNAs frequently deregulated in various human malignancies, it remains unknown if these can help predict recurrence and metastasis in CRC patients. | 28262692 |
| Clinical Coordinator | Epigenetic Alterations | Candidate miRNAs were then tested in two independent cohorts of 111 stage II/III and 139 stage I-III CRC patients, as well as serum samples and matched primary and metastatic liver tissues. | 28262692 |
| Childhood Leukemia | Epigenetic Alterations | Through a comparative sequencing and analysis of RNA content between the MVs from RPMI8226 MM cells (RPMI8226-MVs) and K562 leukemia cells, RPMI8226-MVs were enriched with more renal-pathogenic miRNAs, in which the selective miRNAs may participate in the up-regulation of the levels of cleaved caspase-3. | 28264449 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | Long non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis. | 28268166 |
| oligodendroglioma | Epigenetic Alterations | Genetic and epigenetic stability of oligodendrogliomas at recurrence. | 28270234 |
| oligodendroglioma, Neoplasms | Epigenetic Alterations | To elucidate the genetic and epigenetic background for such behavior and tumor evolution during tumor relapse, we comparatively analyzed 12 pairs of primary and recurrent oligodendrogliomas with 1p/19q-codeletion. | 28270234 |
| Well Differentiated Oligodendroglioma, oligodendroglioma, Neoplasms | Epigenetic Alterations | In summary, although oligodendroglioma displays marked mutational heterogeneity, histological malignant transformation accompanying events such as considerable increase in mutation number and epigenetic profile change were not observed at recurrence, indicating that noticeable temporal and spatial genetic heterogeneity in oligodendrogliomas does not result in rapid tumor progression. | 28270234 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Epigenome-wide discovery and evaluation of leukocyte DNA methylation markers for the detection of colorectal cancer in a screening setting. | 28270869 |
| Clinical Coordinator | Epigenetic Alterations | Although diagnostic performance of the DNA methylation signature identified in this first epigenome-wide association study of leukocyte DNA methylation with CRC in a screening setting is not competitive with established screening tests, the identified markers may contribute to multimarker panels for early detection of CRC. | 28270869 |
| Liver carcinoma | Epigenetic Alterations | Long non-coding RNA UCA1 regulates the expression of Snail2 by miR-203 to promote hepatocellular carcinoma progression. | 28271214 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Long non-coding RNA (LncRNA) urothelial carcinoma-associated 1 (UCA1) is reported to be dysregulated in hepatocellular carcinoma (HCC) progression. | 28271214 |
| Heart failure | Epigenetic Alterations | Several studies have suggested circulating microRNAs (miRs) are associated with heart failure, but these studies were small, and limited to single miR measurements. | 28274577 |
| Small cell carcinoma of lung, Neoplasms | Epigenetic Alterations | The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes. | 28275243 |
| Small cell carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | Elucidation of differentially expressed miRNA-mediated cancer pathways based on SCLC signature may provide new insights into the mechanisms of SCLC pathogenesis. | 28275243 |
| Lichen Planus | Epigenetic Alterations | Gene expression of miRNA-138 and cyclin D1 in oral lichen planus. | 28275859 |
| Breast Carcinoma, Mammary Neoplasms | Epigenetic Alterations | Breast tumor DNA methylation patterns associated with smoking in the Carolina Breast Cancer Study. | 28275920 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Altered DNA methylation contributes to breast cancer development and may provide a mechanistic link between smoking and gene expression changes leading to cancer development or progression. | 28275920 |
| Traumatic | Epigenetic Alterations | MicroRNAs as Novel Biomarkers for the Diagnosis and Prognosis of Mild and Severe Traumatic Brain Injury. | 28279125 |
| Degenerative polyarthritis | Epigenetic Alterations | Increased GPD1L and decreased miRNA-181a were observed in tissues from osteoarthritis patients. | 28280258 |
| Adult T-Cell Lymphoma/Leukemia | Epigenetic Alterations | We profiled miRNAs in Pten-deficient mouse T-ALL and identified miR-26b as a potentially dysregulated gene. | 28280276 |
| Small cell carcinoma of lung | Epigenetic Alterations | These findings suggest that miRNA-related polymorphisms in the PI3K/Akt/mTOR pathway may be valuable biomarkers to complement clinicopathological variables in predicting prognosis of limited-disease SCLC and to facilitate selection of patients likely to benefit from chemoradiotherapy. | 28280736 |
| Merkel cell carcinoma | Epigenetic Alterations | We speculated that the paucity of mutations in virus-positive Merkel cell carcinoma may reflect a pathomechanism that depends on derangements of chromatin without alterations in the DNA sequence (epigenetic dysregulation). | 28281550 |
| Merkel cell carcinoma, Neoplasms | Epigenetic Alterations | Our findings suggest that a PRC2-mediated epigenetic deregulation may play a role in the pathogenesis of virus-positive Merkel cell carcinomas and in tumors with pure histologic features. | 28281550 |
| Neoplasms | Epigenetic Alterations | Recently, Accumulating evidence indicates that long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in human tumor biology and development. | 28282787 |
| Stomach Carcinoma | Epigenetic Alterations | Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression. | 28285404 |
| Metastasis, Neoplasms | Epigenetic Alterations | ZFAS1 is a newly identified long noncoding RNA (lncRNA) that promotes tumor growth and metastasis. | 28285404 |
| Chronic Kidney Diseases, Fibrosis Assessment | Epigenetic Alterations | Renal fibrosis is a common pathological feature of chronic kidney diseases (CKD) and its development and progression are significantly affected by epigenetic modifications such as aberrant miRNA and DNA methylation. | 28285987 |
| Injury of kidney | Epigenetic Alterations | Klotho is an anti-aging and anti-fibrotic protein and its early decline after renal injury is reportedly associated with aberrant DNA methylation. | 28285987 |
| Esophageal carcinoma | Epigenetic Alterations | MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF. | 28288140 |
| Primary malignant neoplasm | Epigenetic Alterations | The discovery of microRNAs created a new milestone in cancer research. | 28288140 |
| Clinical Coordinator, Ulcerative Colitis, Dysplasia | Epigenetic Alterations | Aberrant miRNA expression is a feature of sporadic CRC but much less is known about the changes that occur in dysplasia and in UC. | 28288169 |
| Dysplasia | Epigenetic Alterations | In particular, levels of miR-200b-3p were increased in dysplasia, and this miRNA was localised to epithelial cells in dysplastic lesions and in UC cancers. | 28288169 |
| Inflammatory polyp, Ulcerative Colitis | Epigenetic Alterations | The expression of miRNAs in UC post inflammatory polyps (n = 7) was also assessed. | 28288169 |
| Cardiovascular Diseases | Epigenetic Alterations | There is increasing interest in extracellular RNAs (ex-RNAs), with numerous reports of associations between selected microRNAs (miRNAs) and a variety of cardiovascular disease phenotypes. | 28289238 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer. | 28293327 |
| Neoplasms | Epigenetic Alterations | Expression of mutL homolog 1 (MLH1), a mismatch repair gene that corrects DNA replication errors, is lost in up to 15% of sporadic tumours due to mutation or, more commonly, due to DNA methylation of its promoter CpG island. | 28293327 |
| Clinical Coordinator, Familial Colorectal Cancer Type X, Colorectal Neoplasms, Neoplasms | Epigenetic Alterations | To determine whether this genotype-epigenotype association is present in other tissue types, including colorectal tumours, we assessed DNA methylation in matched normal colorectal tissue, tumour, and PBMC DNA from 349 population-based CRC cases recruited from the Ontario Familial Colorectal Cancer Registry. | 28293327 |
| Colorectal Carcinoma | Epigenetic Alterations | Colorectal cancers (CRCs) undergo distinct genetic and epigenetic alterations. | 28293327 |
| Neoplasms | Epigenetic Alterations | These results indicate that the normal tissue types tested (colorectum and PBMC) experience dynamic genotype-associated epigenetic alterations at the MLH1 shore, whereas tumour DNA incurs aberrant hypermethylation compared to normal DNA. | 28293327 |
| Abnormality of mitochondrial metabolism, Kidney Failure, Acute | Epigenetic Alterations | Differentially expressed miRNAs in sepsis-induced acute kidney injury target oxidative stress and mitochondrial dysfunction pathways. | 28296904 |
| Primary malignant neoplasm, Intrahepatic Route of Drug Administration | Epigenetic Alterations | Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme. | 28297679 |
| Cushing Syndrome | Epigenetic Alterations | Patients with Cushings Syndrome (CS) in remission were used as a model to test the hypothesis that long-standing excessive cortisol exposure induces changes in DNA methylation that are associated with persisting neuropsychological consequences. | 28300138 |
| Liver carcinoma | Epigenetic Alterations | Moreover, we observed extensive intratumoral epigenetic heterogeneity in hepatocellular carcinoma based on multiple independent analytical methods and showed that intratumoral methylation heterogeneity might play important roles in the biology of hepatocellular carcinoma cells. | 28302680 |
| Carcinoma | Epigenetic Alterations | Carcinoma follows a course of multiple changes that are affected by several important factors, with epigenetic silencing of the promoter gene being one of them. | 28303350 |
| Carcinogenesis | Epigenetic Alterations | A series of studies have suggested that epigenetic changes in the anti-aging gene Klotho may be one of the emerging areas of concern in the study of carcinogenesis. | 28303350 |
| Carcinoma | Epigenetic Alterations | We hypothesized that epigenetic silencing of Klotho due to hypermethylation of DNMT3a may be one of the causes of carcinoma in the oral and maxillofacial region. | 28303350 |
| Primary malignant neoplasm | Epigenetic Alterations | Alterations in microRNA expression associated with alcohol consumption in rectal cancer subjects. | 28303484 |
| Primary malignant neoplasm | Epigenetic Alterations | Our results suggest that wine influences miRNA expression in rectal cancer, supporting the hypothesis that components in alcohol influence miRNA expression. | 28303484 |
| Neoplasm Metastasis | Epigenetic Alterations | Next-generation Sequencing for microRNA Profiling: MicroRNA-21-3p Promotes Oral Cancer Metastasis. | 28314265 |
| Squamous cell carcinoma, SERPINB3 wt Allele | Epigenetic Alterations | Dysfunctional microRNAs (miRNAs) play a crucial role in oral squamous cell carcinoma (OSCC) progression. | 28314265 |
| SERPINB3 wt Allele | Epigenetic Alterations | We observed that 45 miRNAs were substantially up-regulated and 17 miRNAs were down-regulated in OSCC tissues. | 28314265 |
| Clinical Coordinator | Epigenetic Alterations | The combination of genetic mutations and epigenetic aberrations specifically in CTCs, will ameliorate CRC diagnosis in the future. | 28314271 |
| Degenerative polyarthritis | Epigenetic Alterations | Epigenetic mechanisms have been reported to play key roles in chondrogenesis and osteoarthritis (OA) development. | 28314754 |
| Degenerative polyarthritis | Epigenetic Alterations | Understanding the epigenetic mechanism of joint cartilage development and homeostasis would be useful for development of new therapeutic modalities for OA. | 28314754 |
| Neoplasms | Epigenetic Alterations | The microRNAs (miRNAs) are involved in multiple pathological processes among various types of tumors. | 28315020 |
| Neoplasms | Epigenetic Alterations | However, the functions of miRNAs in benign brain tumors are largely unexplored. | 28315020 |
| Pituitary Adenoma | Epigenetic Alterations | Our result can provide the evidence on featured miRNAs which play a prominent role in pituitary adenoma as effective biomarkers and therapeutic targets in the future. | 28315020 |
| AMD1 wt Allele | Epigenetic Alterations | Circulating miRNA levels were significantly varied in AMD patients. | 28315863 |
| AMD1 wt Allele | Epigenetic Alterations | Three miRNAs, miR-27a-3p, miR-29b-3p and the miR-195-5p, might be potential diagnostic biomarkers for AMD. | 28315863 |
| Primary malignant neoplasm | Epigenetic Alterations | Increasing evidence suggests that aberrant microRNAs expressions are significantly associated with cancer progression. | 28317618 |
| Neoplasms | Epigenetic Alterations | DNA methylation, especially promoter methylation, which causes the silence/decrease of tumour related genes, has become a focus in various tumour types. | 28319413 |
| Neoplasms | Epigenetic Alterations | Epigenetics, including many oncogenes or tumour suppressor genes, can provide some clues for this kind of disorder. | 28319413 |
| Inflammation | Epigenetic Alterations | MicroRNA-155, which has been shown to play a central role in inflammation and neovascularization, was upregulated with long-term LVAD support. | 28319523 |
| Heart failure | Epigenetic Alterations | MicroRNAs (miRNAs) are 22-23 nucleotide RNAs involved in regulation of multiple biologic processes including the pathogenesis of heart failure (HF). | 28319523 |
| Primary malignant neoplasm | Epigenetic Alterations | The use of circulating microRNAs as biomarkers has opened new opportunities for diagnosis of cancer because microRNAs exhibit tumor-specific expression profiles. | 28321148 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | To screen clinically relevant microRNAs (miRNAs) silenced by DNA methylation in human hepatocellular carcinoma (HCC). | 28321157 |
| Liver neoplasms, Hepatocellular Adenoma, MIR183 wt Allele | Epigenetic Alterations | DNA methylation analysis in healthy liver, benign liver tumors (hepatocellular adenoma and focal nodular hyperplasia) and their corresponding adjacent tissues showed absence of hypermethylation supporting the notion that aberrant methylation at hsa-miR-183 is specific for the malignant transformation of hepatocytes. | 28321157 |
| Hollings Cancer Center | Epigenetic Alterations | miRNA profiling after DNMT knockdown in HCC cell lines revealed upregulation of miR-23, miR-25 and miR-183. | 28321157 |
| Rheumatoid Arthritis | Epigenetic Alterations | MicroRNA-192 suppresses cell proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes by downregulating caveolin 1. | 28321538 |
| Immune System Diseases | Epigenetic Alterations | Epigenetic mechanisms are critical for normal immune development and epigenetic alterations might therefore be possible contributors to immune diseases. | 28322575 |
| S100A4 protein, human | Epigenetic Alterations | The dysregulation of histone acetylation can lead to the uncontrolled activity of different genes, thereby triggering events associated with malignant transformation. | 28326594 |
| Carcinogenesis | Epigenetic Alterations | Oral carcinogenesis is influenced by modifications in epigenetic mechanisms, including changes in histones, which are proteins that support chromatin remodelling for the dynamic regulation of gene expression and silencing. | 28326594 |
| Hypopharyngeal Carcinoma | Epigenetic Alterations | Upregulation of the long noncoding RNA UCA1 affects the proliferation, invasion, and survival of hypopharyngeal carcinoma. | 28327194 |
| ovarian neoplasm | Epigenetic Alterations | Clinical validation of chemotherapy predictors developed on global microRNA expression in the NCI60 cell line panel tested in ovarian cancer. | 28334047 |
| Primary malignant neoplasm | Epigenetic Alterations | Predictors of chemotherapy-resistance were developed based on correlation between miRNA expression and differences in measured growth inhibition in a variety of human cancer cell lines in the presence of Carboplatin, Paclitaxel and Docetaxel. | 28334047 |
| Malignant Peripheral Nerve Sheath Tumor | Epigenetic Alterations | We observed that most patients with two MPNs harbored mutations in genes known to contribute to clonal hematopoiesis through altered epigenetic regulation such as TET2, ASXL1/2, SRSF2, and IDH2 at varying frequencies (1%-47%). | 28335073 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Serum microRNA Expression Profiling: Potential Diagnostic Implications of a Panel of Serum microRNAs for Clear Cell Renal Cell Cancer. | 28336290 |
| Primary malignant neoplasm | Epigenetic Alterations | TS levels were found to be significantly augmented in mesenchymal-like compared to epithelial-like cancer cells, to be regulated by EMT induction, and to negatively correlate with micro-RNAs (miRNAs) usually expressed in epithelial-like cells and known to actively suppress EMT. | 28337746 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer. | 28338293 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Here, we found that the long non-coding RNA 00312 was down-regulated in paired NSCLC tissues and correlated with poor clinical outcome; decreased linc00312 expression in NSCLC was associated with larger and later stage tumours. | 28338293 |
| Neoplasms | Epigenetic Alterations | The abnormal expression of many long non-coding RNAs (lncRNAs) has been reported involved in the progression of various tumours, which can be used as diagnostic indicators or antitumour targets. | 28338293 |
| Carcinoma of lung, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Identification of circulating long non-coding RNA GAS5 as a potential biomarker for non-small cell lung cancer diagnosisnon-small cell lung cancer, long non-coding RNA, plasma, GAS5, biomarker. | 28339045 |
| Primary malignant neoplasm, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Increasing evidence suggest that long non-coding RNA GAS5 plays vital roles in cancer proliferation and differentiation in NSCLC. | 28339045 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-499 rs3746444 A/G polymorphism functions as a biomarker to predict recurrence following endoscopic submucosal dissection in primary early gastric cancer. | 28339066 |
| Stomach Carcinoma | Epigenetic Alterations | Online microRNA (miRNA) target prediction tools were used, which identified PDGFRB as the candidate target gene of miR-499a in gastric cancer cells, and PFGRBR was then confirmed as the direct gene using a luciferase reporter assay system. | 28339066 |
| Sjogrens Syndrome", Lupus Erythematosus | Epigenetic Alterations | MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjogrens syndrome. | 28339495 |
| Autoimmune Diseases | Epigenetic Alterations | However, a given miRNA may have hundreds of different mRNA targets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated miRNA expression profiles could give a better insight into the development of immunological disturbances in autoimmune diseases. | 28339495 |
| Peripheral, Lupus Erythematosus, Systemic, Perceived stress scale, Hyperactive behavior | Epigenetic Alterations | Since the immunopathogenesis of pSS and SLE encompasses pronounced B cell hyperactivity along with specific autoantibody production, we paid a special attention on the association between miRNA expression levels and altered peripheral B cell distribution. | 28339495 |
| Lupus Erythematosus, Systemic, Perceived stress scale | Epigenetic Alterations | The observed differences in miRNA expression profiles and the better understanding of immune regulatory mechanisms of miRNAs may help to elucidate the pathogenesis of SLE and pSS. | 28339495 |
| Lupus Erythematosus, Systemic | Epigenetic Alterations | In SLE patients 135, while in pSS patients 26 miRNAs showed altered expression. | 28339495 |
| Lupus Erythematosus, Systemic, Perceived stress scale | Epigenetic Alterations | Interestingly, the 25 miRNAs including miR-146a, miR-16 and miR-21, which were over-expressed in pSS patients, were found to be elevated in SLE group, as well. | 28339495 |
| Stomach Carcinoma | Epigenetic Alterations | The Profile of Serum microRNAs Predicts Prognosis for Resected Gastric Cancer Patients Receiving Platinum-Based Chemotherapy. | 28341869 |
| Obesity | Epigenetic Alterations | There is growing evidence that circulating microRNAs (miRNAs) play an important role in obesity. | 28342299 |
| Weight Gain, Obesity, Weight decreased | Epigenetic Alterations | The findings provide evidence that circulating miRNAs play important roles in obesity and weight gain and suggest new targets for understanding the mechanisms of weight gain and developing weight loss intervention strategies. | 28342299 |
| Coronary Artery Disease, Hypercholesterolemia | Epigenetic Alterations | Translating the microRNA signature of microvesicles derived from human coronary artery smooth muscle cells in patients with familial hypercholesterolemia and coronary artery disease. | 28342976 |
| Family history | Epigenetic Alterations | Exposure to atherogenic lipoproteins modifies the miRNA profile of CASMC-derived microvesicles and these alterations are reflected in patients with FH. | 28342976 |
| Transitional cell carcinoma of ureter | Epigenetic Alterations | Genetic and epigenetic alterations play an important role in urothelial cancer pathogenesis. | 28344356 |
| Neoplasms | Epigenetic Alterations | MicroRNAs are emergent players of epigenetics that function as oncogenes or tumor suppressors and that have been implicated in regulating diverse cellular pathways. | 28345456 |
| Malignant Neoplasms, Metastasis, Neoplasms | Epigenetic Alterations | MiR-10b is an oncogenic microRNA involved in tumor invasion and metastasis in various cancers. | 28345456 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer. | 28345460 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Remarkably, restoration of coactivator-associated arginine methyltransferase 1 in microRNA-195-5p-transfected colorectal cancer cells partially abrogated the inhibition of cell proliferation and colony formation mediated through microRNA-195-5p. | 28345460 |
| Colorectal Cancer Pathway | Epigenetic Alterations | These data confirm that microRNA-195-5p might function as an anti-tumor microRNA in colorectal cancer exerting critical control over coactivator-associated arginine methyltransferase 1 expression. | 28345460 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The newly identified microRNA-195-5p/coactivator-associated arginine methyltransferase 1 axis may act as a novel promising therapeutic target for colorectal cancer treatment. | 28345460 |
| Neoplasms | Epigenetic Alterations | miR-9 was initially identified as an epigenetically regulated miRNA in tumours, but inconsistent findings have been reported so far. | 28345661 |
| Neoplasms | Epigenetic Alterations | No significant correlation between promoter methylation and pri-miRNAs expressions was found either in tumours or in NBTs. | 28345661 |
| Gastric Cardia Adenocarcinoma | Epigenetic Alterations | Promoter hypermethylation-mediated downregulation of miR-770 and its host gene MEG3, a long non-coding RNA, in the development of gastric cardia adenocarcinoma. | 28345805 |
| CO-methylating acetyl-CoA synthase activity | Epigenetic Alterations | Our results may suggest that immune signaling and cellular functions might be regulated at an epigenetic level in ACS. | 28348007 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Upregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial-mesenchymal transition in vitro and predicts poor prognosis in glioma. | 28349823 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Zinc finger antisense 1 is a novel long noncoding RNA whose clinical significance, biological function, and underlying mechanism are still undetermined in glioma. | 28349823 |
| Malignant Neoplasms | Epigenetic Alterations | Increasing evidence indicates that long noncoding RNAs play important roles in development and progression of various cancers. | 28349823 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNA signature is altered in different disease states including cancer, and some microRNAs act as oncogenes or tumor suppressors. | 28349829 |
| Meningioma | Epigenetic Alterations | Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma. | 28349893 |
| Meningioma | Epigenetic Alterations | the association between miRNA expression and meningioma, is continuously gaining more importance in the wider context of the recent developments in genetic treatments. | 28349893 |
| cervical cancer | Epigenetic Alterations | Aberrant gene-specific DNA methylation signature analysis in cervical cancer. | 28351298 |
| cervical cancer, Cervical Intraepithelial Neoplasia | Epigenetic Alterations | Multicomponent molecular modifications such as DNA methylation may offer sensitive and specific cervical intraepithelial neoplasia and cervical cancer biomarkers. | 28351298 |
| Malignant Neoplasms | Epigenetic Alterations | In recent years, studies on the mechanisms of lung tumorigenesis and development have in part focused on the microRNAs for their crucial role in the progress of different cancers. | 28351305 |
| Aggressive behavior, Neoplasms | Epigenetic Alterations | Of the three differentially expressed circulating miRNA, miRNA192 was significantly increased both in circulation and in tumour tissue and correlated with tumour stage and aggressiveness (r = 0.96, P < 0.0001). | 28351309 |
| Periampullary carcinoma | Epigenetic Alterations | Since the prognosis for pancreatobiliary subtype of periampullary carcinoma is poor, we assessed the prognostic relevance of miRNAs in combination with CA19-9 as noninvasive biomarker in periampullary carcinoma. | 28351309 |
| Neoplasms | Epigenetic Alterations | Tumour tissues were subjected to staging and subtyping prior to determining differentially expressed miRNAs in them by quantitative real-time polymerase chain reaction (qRT-PCR). | 28351309 |
| Degenerative polyarthritis | Epigenetic Alterations | MiRNA expression in the cartilage of patients with osteoarthritis. | 28351380 |
| Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm | Epigenetic Alterations | Aberrant DNA methylation profiles are a characteristic of all known cancer types, epitomized by the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC). | 28351398 |
| Clinical Coordinator | Epigenetic Alterations | DNA methylation in CRC was analysed using the Illumina HumanMethylation450K array. | 28351398 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Our genome-wide characterization of DNA methylation in colorectal cancer has identified 132 genes hypermethylated in 100% of CIMP-H samples. | 28351398 |
| Rheumatoid Arthritis | Epigenetic Alterations | DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis. | 28356135 |
| melanoma | Epigenetic Alterations | Circulating microRNA-194 regulates human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway. | 28358423 |
| melanoma | Epigenetic Alterations | We found that microRNA-194 expression was markedly suppressed in human melanoma patients, compared with negative control group. | 28358423 |
| melanoma | Epigenetic Alterations | Taken together, these data indicate that circulating microRNA-194 regulated human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway. | 28358423 |
| Cirrhotic, Liver carcinoma | Epigenetic Alterations | A Circulating MicroRNA Signature Capable of Assessing the Risk of Hepatocellular Carcinoma in Cirrhotic Patients. | 28364124 |
| Cirrhotic, Hollings Cancer Center | Epigenetic Alterations | In summary, a circulating miRNA-based score was developed that is capable of assessing HCC risks in cirrhotic patients. | 28364124 |
| Malignant Neoplasms | Epigenetic Alterations | Dysregulation of miRNAs is noted in many cancers, and circulating miRNAs can be readily assayed. | 28364124 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Lung adenocarcinomas are characterized by a variety of genetic and epigenetic changes that lead to activation of specific signaling pathways. | 28364271 |
| Hollings Cancer Center, Primary malignant neoplasm | Epigenetic Alterations | MiRNA and mRNA expression data for HCC were accessed from The Cancer Genome Atlas (TCGA). | 28365450 |
| Liver carcinoma | Epigenetic Alterations | miRNA-101-1 and miRNA-221 expressions and their polymorphisms as biomarkers for early diagnosis of hepatocellular carcinoma. | 28366737 |
| Hollings Cancer Center | Epigenetic Alterations | Of these miRNAs, are miR-221 and miR-101-1, which their aberrant expressions have been reported to play an important role in HCC. | 28366737 |
| Alzheimers Disease | Epigenetic Alterations | These data suggest that interrelated diurnal and seasonal epigenetic and transcriptional rhythms may be an important feature of human brain biology, and perhaps human biology more broadly, and that changes in such rhythms may be consequences of, or contributors to, diseases such as Alzheimers disease. | 28368004 |
| Degenerative polyarthritis, Rheumatoid Arthritis, Kashin-Beck Disease | Epigenetic Alterations | Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis. | 28373711 |
| Kabardian language | Epigenetic Alterations | Another independent mRNA expression profile dataset of 20 KBD patients and 15 healthy controls were integrated with the miRNA expression profiles of KBD. | 28373711 |
| Degenerative polyarthritis, Right arm | Epigenetic Alterations | Our results demonstrated the altered miRNAs expression profiles of KBD comparing to healthy controls, OA and RA, which provide novel clues for clarifying the mechanism of KBD. | 28373711 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Thus far, the mechanism of epigenetic silencing of the SHP-1 tyrosine phosphatase gene that occurs in chronic myelogenous leukemia cells remains poorly understood. | 28376405 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | HOX transcript antisense RNA (HOTAIR), a long noncoding RNA (lncRNA) expressed from the HOXC locus, has been recently revealed as an oncogenic regulator in ESCC. | 28376832 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been reported to regulate the sensitivity of different cancer cells to chemoradiotherapy. | 28376901 |
| ELN wt Allele | Epigenetic Alterations | While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased epigenetic age according to a DNA methylation based biomarker of aging (the "Epigenetic Clock"). | 28377537 |
| Werner Syndrome | Epigenetic Alterations | Accelerated epigenetic aging in Werner syndrome. | 28377537 |
| Salivary Gland Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs), small noncoding RNAs, and posttranscriptional regulators of mRNA are poorly described in different subtypes of salivary gland tumours. | 28377929 |
| Neoplasms | Epigenetic Alterations | Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours. | 28377929 |
| Colorectal Cancer Pathway | Epigenetic Alterations | DNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancer. | 28378457 |
| Clinical Coordinator | Epigenetic Alterations | While BRAF- and KRAS-mutation(+) CRC strongly correlated with HME and IME, respectively, clinicopathological features of NRAS-mutation(+) CRC, including association with DNA methylation, remain unclear. | 28378457 |
| Von Hippel-Lindau Syndrome, Hemangioblastoma | Epigenetic Alterations | Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system. | 28379443 |
| VHL protein, human | Epigenetic Alterations | VHL promoter hypermethylation was detected only in sporadic HBs (33%), indicating that epigenetic suppression of VHL is a common mechanism in sporadic HBs. | 28379443 |
| Osteosarcoma | Epigenetic Alterations | MicroRNA-126 Inhibits Proliferation, Migration, Invasion, and EMT in Osteosarcoma by Targeting ZEB1. | 28379605 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | We previously reported on the role of microRNA (miR)-145 as a tumor-suppressor in human bladder cancer (BC) cells. | 28380435 |
| Liver carcinoma | Epigenetic Alterations | Long non-coding RNA colon cancer-associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma progression. | 28381168 |
| Malignant Neoplasms | Epigenetic Alterations | Recently, long non-coding RNAs have been demonstrated to participate in pathogenesis of many diseases including the progression in several cancers. | 28381168 |
| Stomach Carcinoma | Epigenetic Alterations | Effect of histone modifications on hMLH1 alternative splicing in gastric cancer. | 28381181 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic regulation may play more important roles than gene mutations in DNA damage repair genes to drive carcinogenesis. | 28381181 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Expression of claudin 1, claudin 4, and claudin 7 in colorectal cancer and its relation with CLDN DNA methylation patterns. | 28381183 |
| Neoplasms | Epigenetic Alterations | To detect the DNA methylation pattern of CLDN1, 4, and 7, genomic DNA was extracted from both the tumor and the adjacent nonneoplastic mucosa. | 28381183 |
| Colorectal Cancer Pathway | Epigenetic Alterations | However, the role of epigenetic modifications in these genes and their role in colorectal cancer is unknown. | 28381183 |
| Colorectal Cancer Pathway, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression. | 28381186 |
| Malignant Neoplasms | Epigenetic Alterations | The plasmacytoma variant translocation 1 gene (PVT1) is a large non-coding locus at adjacent of c-Myc, and long non-coding RNA PVT1 is now recognized as a cancerous gene co-amplified with c-Myc in various cancers. | 28381186 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas. | 28381277 |
| Squamous cell carcinoma of the head and neck, Human papilloma virus infection | Epigenetic Alterations | We identified a novel epigenetic signature of HPV infection in HNSCCs which is independent of the anatomic site, is functionally correlated with gene expression and may be leveraged for improved stratification of prognosis in HNSCCs. | 28381277 |
| Steatohepatitis, Hyperlipidemia | Epigenetic Alterations | miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression. | 28381526 |
| Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-93 (miR-93) usually acts as a promoter of tumor progression in several human carcinomas. | 28382439 |
| Corneal dystrophy | Epigenetic Alterations | Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy. | 28384203 |
| Electron-Capture Dissociation | Epigenetic Alterations | Here, we report on and compare the DNA methylation landscape of normal human corneal endothelial (CE) tissue and CE from FECD patients using the Illumina Infinium HumanMethylation450 (HM450) DNA methylation array. | 28384203 |
| Electron-Capture Dissociation | Epigenetic Alterations | We show that DNA methylation profiles are distinct between control and FECD samples. | 28384203 |
| Electron-Capture Dissociation, Loss | Epigenetic Alterations | Our results suggest that altered DNA methylation patterns may contribute to loss of corneal transparency in FECD through a global accumulation of sporadic DNA methylation changes in genes critical to basic CE biological processes. | 28384203 |
| Electron-Capture Dissociation | Epigenetic Alterations | Epigenetic modifications that occur in FECD are unknown. | 28384203 |
| Admitting diagnosis | Epigenetic Alterations | The interaction between DNA methylation of CpG5 and AA genotype of rs6265 had a risk role in the development of aMCI (p = 0.019, OR = 1.233, 95% CI: 1.117-1.303) and its progression to AD (p = 0.003, OR = 1.399, 95% CI: 1.198-1.477). | 28387675 |
| Admitting diagnosis | Epigenetic Alterations | The interactions between DNA methylation (CpG5) of the BDNF gene promoter and the tag SNP (rs6265) play important roles in the etiology of aMCI and its conversion to AD. | 28387675 |
| Admitting diagnosis, "Alzheimers Disease | Epigenetic Alterations | Alzheimers disease (AD) is a complex multifactorial disease influenced by both genetic and epigenetic factors. | 28387675 |
| Stomach Carcinoma | Epigenetic Alterations | Clinicopathological significance of the microRNA-146a/WASP-family verprolin-homologous protein-2 axis in gastric cancer. | 28387985 |
| DICER1 protein, human | Epigenetic Alterations | Dicer and Drosha, which have a role in activation process of miRNA, also act in a double-strand DNA break (DSB) repair mechanism. | 28388279 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Cell-free microRNA expression signatures in urine serve as novel noninvasive biomarkers for diagnosis and recurrence prediction of bladder cancer. | 28388561 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Urinary microRNAs (miRNAs) are potential biomarkers for the noninvasive diagnosis of bladder cancer (BC). | 28388561 |
| Papillary thyroid carcinoma | Epigenetic Alterations | MicroRNA-based molecular classification of papillary thyroid carcinoma. | 28393181 |
| F9 gene | Epigenetic Alterations | These findings provide new insights into the molecular classification of PTC, showing that different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence. | 28393181 |
| cervical cancer | Epigenetic Alterations | MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer. | 28393232 |
| cervical cancer | Epigenetic Alterations | Over the past decade, an increasing number of studies indicate a central role for microRNAs in the initiation and progression of cervical cancer. | 28393232 |
| Neoplasms | Epigenetic Alterations | MicroRNA (miRNA) deregulation has recently emerged as an important phenomenon in tumor development and progression, however, the mechanisms remain largely unstudied. | 28398479 |
| Prostate Cancer Pathway | Epigenetic Alterations | Clinical significance of miRNA host gene promoter methylation in prostate cancer. | 28398479 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Methylation status of particular miRNA host genes as independent variables or in combinations might assist physicians in identifying poor prognosis PCa patients preoperatively. | 28398479 |
| Neoplasms | Epigenetic Alterations | Epigenetic Regulation of CD133 in Gastrointestinal Stromal Tumors. | 28398518 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | Our results strongly suggest epigenetic regulation of CD133 expression by promoter methylation in GISTs. | 28398518 |
| Malignant Neoplasms, cervical cancer | Epigenetic Alterations | Thus, besides identifying the deregulated expression of HOX cluster members in HPV16 positive cervical cancer and their association with EMT, our study highlighted the mechanism of HPV16 E7-mediated epigenetic regulation of HOX genes in such cancers, potentially serving as bedrock for functional studies in the future. | 28402266 |
| Breast Carcinoma, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The MicroRNA miR-210 Is Expressed by Cancer Cells but Also by the Tumor Microenvironment in Triple-Negative Breast Cancer. | 28402752 |
| Gastrointestinal Stromal Tumors | Epigenetic Alterations | MiRNA profiling of gastrointestinal stromal tumors by next-generation sequencing. | 28402935 |
| malignant disease, Gastrointestinal Stromal Tumors | Epigenetic Alterations | These data reveal a detailed miRNA profile of GIST and highlight new candidates that may be important in the development of malignant disease. | 28402935 |
| Tetranitromethane | Epigenetic Alterations | The expression of microRNA-203 was progressively lower in relation to the TNM staging and was higher in the patient group in clinical remission. | 28403349 |
| Colonic Neoplasms | Epigenetic Alterations | The therapy of colon and rectum tumors based on microRNAs remains under investigation reserving huge potential for future applications and clinical interventions in conjunction with existing therapies. | 28403349 |
| Carcinogenesis, Human papilloma virus infection | Epigenetic Alterations | We suggest at least two pathways for penile carcinogenesis, one HPV-independent linked to epigenetic events, probably via p16ink4a inactivation; and another, dependent on HPV infection. | 28403538 |
| Prostate Cancer Pathway | Epigenetic Alterations | Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression. | 28403887 |
| Carcinogenesis | Epigenetic Alterations | Our findings point to epigenetic mark H3K27me3 as an important event in prostate carcinogenesis and progression. | 28403887 |
| Neoplasms | Epigenetic Alterations | We hypothesize that DFNA5 promoter methylation can be a valuable epigenetic biomarker, based upon strong indications for its role as tumor suppressor gene and its function in regulated cell death. | 28404884 |
| Neoplasms, Renal Cell Carcinoma Pathway | Epigenetic Alterations | OSR1 is a novel epigenetic silenced tumor suppressor regulating invasion and proliferation in renal cell carcinoma. | 28404905 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA regulation of progesterone receptor in breast cancer. | 28404930 |
| Breast Carcinoma | Epigenetic Alterations | A significant reciprocal correlation between PR mRNA and the miRNA levels were identified suggesting a role for miR-181a, miR-23a and miR-26b in PR regulation in breast cancer. | 28404930 |
| Mammary Neoplasms | Epigenetic Alterations | Then, expression levels of these miRNAs were measured in Formalin-Fixed, Paraffin-Embedded (FFPE) samples of 29 ER-positive breast cancer tumors and adjacent normal breast tissues. | 28404930 |
| Breast Carcinoma | Epigenetic Alterations | The diagnostic and prognostic potential of these miRNAs in breast cancer should be further evaluated. | 28404930 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Aberrant levels of circulating microRNAs are potential biomarkers for the early detection of colorectal cancer. | 28404964 |
| Human papilloma virus infection | Epigenetic Alterations | Results demonstrate significant associations between lncRNA-based clustering and DNA methylation, TP53 mutation, and human papillomavirus infection. | 28405244 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have emerged as key players in a remarkably variety of biological processes and pathologic conditions, including cancer. | 28405244 |
| Esophageal carcinoma | Epigenetic Alterations | Long non-coding RNA MEG3 induces cell apoptosis in esophageal cancer through endoplasmic reticulum stress. | 28405686 |
| Fibrosis, Liver | Epigenetic Alterations | Based on our recent finding that disruption of bile acid (BA) homeostasis in mice results in the induction of hepatic long noncoding RNA H19 expression, we sought to elucidate the role of H19 in cholestatic liver fibrosis. | 28407375 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | We performed cytosine methylation sequencing on genetically diverse patients with acute myeloid leukemia (AML) and found leukemic DNA methylation patterning is primarily driven by nonpromoter regulatory elements and CpG shores. | 28408400 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers. | 28408400 |
| MICROPHTHALMIA, SYNDROMIC 7 | Epigenetic Alterations | AMLs with dominant hypermethylation featured greater epigenetic disruption of promoters, whereas those with dominant hypomethylation displayed greater disruption of distal and intronic regions. | 28408400 |
| MICROPHTHALMIA, SYNDROMIC 7 | Epigenetic Alterations | Notably, co-occurrence of both mutations resulted in epigenetic antagonism, with most CpGs affected by either mutation alone no longer affected in double-mutant AMLs. | 28408400 |
| S100A4 protein, human | Epigenetic Alterations | Importantly, this epigenetic antagonism precedes malignant transformation and can be observed in preleukemic LSK cells from Idh2R140Q or Dnmt3aR882H single-mutant and Idh2R140Q/Dnmt3aR882H double-mutant mice. | 28408400 |
| MICROPHTHALMIA, SYNDROMIC 7, Leukemia, Myelocytic, Acute | Epigenetic Alterations | Notably, IDH/DNMT3A double-mutant AMLs manifested upregulation of a RAS signaling signature and displayed unique sensitivity to MEK inhibition ex vivo as compared with AMLs with either single mutation.Significance: AML is biologically heterogeneous with subtypes characterized by specific genetic and epigenetic abnormalities. | 28408400 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Development of a novel prognostic signature of long non-coding RNAs in lung adenocarcinoma. | 28409273 |
| Malignant Neoplasms | Epigenetic Alterations | Increasing evidence suggests that long non-coding RNAs (lncRNAs) may play a crucial role in many biological processes in a variety of cancers and serve as the basis for many clinical applications including prognostic biomarkers and potential therapeutic targets. | 28409273 |
| Hollings Cancer Center | Epigenetic Alterations | We conclude that hsa_circ_0005986 function as microRNA sponge in tumorigenesis and can be used as a novel biomarker for HCC. | 28410211 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Genetic variants in regulatory regions of some miRNAs might be involved in non-small cell lung cancer susceptibility and survival. | 28410417 |
| Primary malignant neoplasm | Epigenetic Alterations | UNCX expression turned out to be associated, and significantly correlated, with DNA methylation increase at its canyon borders based on data in our patients and in archived data of patients from The Cancer Genome Atlas. | 28411256 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | We here describe a leukemogenic role of the homeobox gene UNCX, activated by epigenetic modifications in acute myeloid leukemia (AML). | 28411256 |
| Reduced antigen-specific T cell proliferation, Leukemia, Myelocytic, Acute | Epigenetic Alterations | In summary, our findings suggest a novel leukemogenic role of UNCX, associated with epigenetic modifications and with impaired cell proliferation and differentiation in AML. | 28411256 |
| Pheochromocytoma | Epigenetic Alterations | MicroRNA 183 family profiles in pheochromocytomas are related to clinical parameters and SDHB expression. | 28412207 |
| Alzheimers Disease | Epigenetic Alterations | DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimers disease. | 28412600 |
| Admitting diagnosis | Epigenetic Alterations | Lower DNA methylation at TREM2 intron 1 caused higher TREM2 mRNA expression in the leukocytes of AD subjects versus controls and may be a biomarker for AD. | 28412600 |
| DNA Damage, Chronic Lymphocytic Leukemia | Epigenetic Alterations | The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia. | 28412730 |
| Prostate Cancer Pathway | Epigenetic Alterations | Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns. | 28412973 |
| Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation is a stable genomic modification that is detectable in peripheral patient fluids such as urine and blood plasma that could serve as a non-invasive diagnostic biomarker for prostate cancer. | 28412973 |
| Malignant neoplasm of prostate | Epigenetic Alterations | We measured genome-wide DNA methylation patterns in 73 clinically annotated fresh-frozen prostate cancers and 63 benign-adjacent prostate tissues using the Illumina Infinium HumanMethylation450 BeadChip array. | 28412973 |
| Malignant neoplasm of prostate | Epigenetic Alterations | Furthermore, by overlaying ENCODE transcription factor binding data, we observed an enrichment of enhancer of zeste homolog 2 binding in gene regulatory regions with higher DNA methylation in malignant prostate tissues. | 28412973 |
| Prostate Cancer Pathway | Epigenetic Alterations | DNA methylation patterns are greatly altered in prostate cancer tissue in comparison to benign-adjacent tissue. | 28412973 |
| Prostate Cancer Pathway, Malignant neoplasm of prostate | Epigenetic Alterations | We have discovered patterns of DNA methylation marks that can distinguish prostate cancers with high specificity and sensitivity in multiple patient tissue cohorts, and we have identified transcription factors binding in these differentially methylated regions that may play important roles in prostate cancer development. | 28412973 |
| Malignant Neoplasms | Epigenetic Alterations | The long non-coding RNAs (lncRNAs) have been recently shown to participate in the progression of a variety of cancers. | 28415044 |
| Peripheral | Epigenetic Alterations | Micro RNA-98 suppresses interleukin-10 in peripheral B cells in patient post-cardio transplantation. | 28415669 |
| Secondary malignant neoplasm of liver, Malignant tumor of colon | Epigenetic Alterations | Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer. | 28415718 |
| Malignant tumor of colon | Epigenetic Alterations | We have profiled 754 miRNAs in 15 colon cancer plasma samples from the tumor-draining vein, the mesenteric vein (MV), identifying 13 microRNAs associated with relapse. | 28415718 |
| Neoplasms | Epigenetic Alterations | Before reaching a peripheral vein (PV), miRNAs released by the tumor are diluted and dispersed throughout the body or even retained in a specific organ. | 28415718 |
| Malignant tumor of colon | Epigenetic Alterations | The prognostic impact of these miRNAs were validated in 50 MV and 50 paired PV plasma samples of stage I-III colon cancer patients. | 28415718 |
| Malignant tumor of colon, Neoplasms | Epigenetic Alterations | Our results indicate that in colon cancer, the primary tumor releases high concentrations of miRNAs through the MV, and some of them are contained in tumor derived exosomes. | 28415718 |
| Primary Neoplasm, Colorectal Cancer Pathway, Secondary malignant neoplasm of liver | Epigenetic Alterations | Differential microRNA expression profiling in primary tumors and matched liver metastasis of patients with colorectal cancer. | 28415758 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | Thirteen miRNAs were deregulated in pCRCs compared to their matched liver metastases. | 28415758 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | Seventeen miRNAs were chosen for validation, which confirmed significantly reduced expression of miR-99b-5p, miR-377 and miR-200c and increased expression of miR-196b-5p in the tissue of liver metastasis. | 28415758 |
| Secondary malignant neoplasm of liver | Epigenetic Alterations | Firstly, affymetrix microarrays involving 1036 miRNAs were performed in two pairs of primary CRCs (pCRCs) and their matched liver metastases. | 28415758 |
| Clinical Coordinator | Epigenetic Alterations | These miRNAs may function as prognostic factors in patients with metastatic CRC. | 28415758 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs. | 28415821 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | We adopted into RNA-sequencing technologies to construct the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). | 28415821 |
| Primary malignant neoplasm | Epigenetic Alterations | Expression of miR-150-5p (guide strand miRNA) and miR-150-3p (passenger strand miRNA) were significantly silenced in cancer tissues, suggesting both miRNAs act as antitumor miRNAs in HNSCC cells. | 28415821 |
| Primary malignant neoplasm | Epigenetic Alterations | Our signature revealed that a total of 160 miRNAs (44 upregulated and 116 downregulated) were aberrantly expressed in cancer tissues. | 28415821 |
| Aggressive behavior | Epigenetic Alterations | Ectopic expression of mature miRNAs, miR-150-5p and miR-150-3p inhibited cancer cell aggressiveness. | 28415821 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. | 28416970 |
| Comorbidity, Chronic Obstructive Airway Disease | Epigenetic Alterations | Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, and comorbidity in the lungs of patients with chronic obstructive pulmonary disease (COPD). | 28416970 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Our study suggests that DNA methylation in suggestive genes, such as NOS1AP, BID, and GABRB1 may be used as epigenetic signatures in smokers and patients with COPD if the same is validated in a larger cohort. | 28416970 |
| Colorectal Carcinoma, Neoplasms | Epigenetic Alterations | Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor. | 28418861 |
| Stomach Carcinoma | Epigenetic Alterations | Early detection of gastric cancer using global, genome-wide and IRF4, ELMO1, CLIP4 and MSC DNA methylation in endoscopic biopsies. | 28418867 |
| Stomach Carcinoma, Gastritis | Epigenetic Alterations | Global, epigenome wide and gene-specific DNA methylation analyses were used in a Phase I Biomarker Development Trial to identify a continuous biomarker panel that combines a Global DNA Methylation Index (GDMI) and promoter DNA methylation levels of IRF4, ELMO1, CLIP4 and MSC.We observed an inverse association between the GDMI and histological progression to gastric cancer, when comparing gastritis patients without metaplasia (mean = 5.74, 95% CI, 4.97-6.50), gastritis patients with metaplasia (mean = 4.81, 95% CI, 3.77-5.84), and gastric cancer cases (mean = 3.38, 95% CI, 2.82-3.94), respectively (p < 0.0001). | 28418867 |
| Breast Carcinoma | Epigenetic Alterations | In the present study, upon studies of breast cancer cell lines and tissues, we showed that microRNA -196a-3p is decreased by transforming growth factor-b1 in breast cancer cells and associated with breast cancer progression. | 28418877 |
| Breast Carcinoma | Epigenetic Alterations | Moreover, transforming growth factor-b1-mediated inhibition of microRNA -196a-3p and activation of neuropilin-2were required for transforming growth factor-b1-induced migration and invasion of breast cancer cells. | 28418877 |
| Secondary malignant neoplasm of female breast, Breast Carcinoma | Epigenetic Alterations | Collectively, our findings strongly indicate that microRNA -196a-3p is a predictive biomarker of breast cancer metastasis and patient survival and a potential therapeutic target in metastatic breast cancer. | 28418877 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs are important factors in the development and progression of many malignancies. | 28418877 |
| Malignant tumor of colon | Epigenetic Alterations | Our study is of potential clinical interest because agents that promote or maintain histone acetylation through HDAC inhibition and/or HAT stimulation, may help to lower colon adenoma/carcinoma incidence, especially in high-risk families, or could be included in therapeutic protocols to treat advanced colon cancer. | 28418886 |
| Acute myocardial infarction | Epigenetic Alterations | Expression pattern of genome-scale long noncoding RNA following acute myocardial infarction in Chinese Uyghur patients. | 28418905 |
| Fibromatosis, Aggressive | Epigenetic Alterations | Human microRNA expression in sporadic and FAP-associated desmoid tumors and correlation with beta-catenin mutations. | 28418912 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Genetic variation of long non-coding RNA TINCR contribute to the susceptibility and progression of colorectal cancer. | 28418933 |
| Clinical Coordinator, Histopathologic Grade differentiation, Neoplasms | Epigenetic Alterations | Herein, we explored effect of genetic variants of Tissue differentiation-inducing non-protein coding RNA (TINCR), a key lncRNA required for somatic tissue differentiation and tumor progression, on risk and progression of CRC. | 28418933 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) serve critical roles in cancer development and progression. | 28418933 |
| Glioblastoma, Neoplasms | Epigenetic Alterations | This suggests that non-responding glioblastomas progress chaotically without following distinct gene expression changes while responding tumors adaptively respond or progress by means of the same transcriptional changes. | 28420326 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Here we tested the hypothesis whether DNA methylation of genes part of the Wnt signaling pathway could help the diagnosis of non-small cell lung cancer (NSCLC). | 28422739 |
| Neuroblastoma, Neoplasms | Epigenetic Alterations | These findings highlight the importance of Lamin A/C epigenetic inactivation for a subset of neuroblastomas, leading to enhanced tumour properties and cytoskeletal changes. | 28422997 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Although PRDM14 is elevated in several cancers, it is unclear if and how PRDM14 confers stem cell-like properties and epigenetic changes to cancer cells. | 28423353 |
| Primary malignant neoplasm | Epigenetic Alterations | Here, we examined the phenotypic characteristics and epigenetic and gene expression profiles of cancer cells that differentially express PRDM14, and assessed the potential of PRDM14-targeted cancer therapy. | 28423353 |
| Metastasis | Epigenetic Alterations | Epigenetic inactivation of the EMT-TFs/miR-34a pathway can potentially alter the equilibrium of these regulations, facilitating EMT and metastasis in BC. | 28423483 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-34a targets epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs) and inhibits breast cancer cell migration and invasion. | 28423483 |
| Neoplasm Metastasis | Epigenetic Alterations | MicroRNA-34a (miR-34a) plays an essential role against tumorigenesis and progression of cancer metastasis. | 28423483 |
| Liver carcinoma | Epigenetic Alterations | Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma. | 28423509 |
| Hollings Cancer Center | Epigenetic Alterations | Our data indicate that pharmacological interference of G9a might be a novel epigenetic approach for the treatment of HCC. | 28423509 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Long non-coding RNAs, which have been reported in many cancer types, are a potential new class of biomarkers for tumor diagnosis. | 28423525 |
| Stomach Carcinoma | Epigenetic Alterations | The combination of circulating long noncoding RNAs AK001058, INHBA-AS1, MIR4435-2HG, and CEBPA-AS1 fragments in plasma serve as diagnostic markers for gastric cancer. | 28423525 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | DNA methylation intratumor heterogeneity in localized lung adenocarcinomas. | 28423542 |
| Neoplasms | Epigenetic Alterations | This is in contrast to somatic mutations, of which approximately 77% were shared events amongst all regions of individual tumors, suggesting that while the majority of somatic mutations were early clonal events, the tumor-specific DNA methylation might be associated with later branched evolution of these 11 tumors. | 28423542 |
| Neoplasms | Epigenetic Alterations | Furthermore, our data showed that a higher extent of DNA methylation ITH was associated with larger tumor size (average Euclidean distance of 35.64 (> 3cm, median size) versus 27.24 (<= 3cm), p = 0.014), advanced age (average Euclidean distance of 34.95 (above 65) verse 28.06 (below 65), p = 0.046) and increased risk of postsurgical recurrence (average Euclidean distance of 35.65 (relapsed patients) versus 29.03 (patients without relapsed), p = 0.039). | 28423542 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We show that the epigenetic age estimated from blood DNA methylation data is statistically significantly associated to future breast and male colorectal cancer development. | 28423572 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Acceleration of leukocytes epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer. | 28423572 |
| Primary malignant neoplasm | Epigenetic Alterations | Changes in blood epigenetic age have been associated with several pathological conditions and have recently been described to anticipate cancer development. | 28423572 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Role of microRNA-21 in radiosensitivity in non-small cell lung cancer cells by targeting PDCD4 gene. | 28423589 |
| Nasopharyngeal carcinoma | Epigenetic Alterations | Epstein-Barr virus encoded microRNA BART7 regulates radiation sensitivity of nasopharyngeal carcinoma. | 28423621 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | MicroRNAs (miRNAs) play critical roles in hepatocellular carcinoma (HCC) progression and are key determinants of prognosis. | 28423650 |
| Gastric Adenocarcinoma | Epigenetic Alterations | A novel microRNA signature predicts survival in stomach adenocarcinoma. | 28423653 |
| Malignant Neoplasms | Epigenetic Alterations | Recent microRNA (miRNA) expression profiling studies suggest the clinical use of miRNAs as potential prognostic biomarkers in various malignancies. | 28423653 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Long non-coding RNA LUCAT1 is associated with poor prognosis in human non-small lung cancer and regulates cell proliferation via epigenetically repressing p21 and p57 expression. | 28423699 |
| Metastasis | Epigenetic Alterations | Recently, long non-coding RNAs (lncRNAs) have been recognized as playing key roles in regulating cellular processes, such as proliferation, invasion, and metastasis. | 28423699 |
| Malignant neoplasm of breast, Neoplasms | Epigenetic Alterations | We then determined the genetic relationships between the histologically distinct compartments.Results: In each case, the tumor components have nearly identical landscapes of somatic mutation, implying that the differing histologies do not derive from genetic clonal divergence.Conclusions: A shared origin for tumors with differing histologies suggests that epigenetic or noncoding changes may mediate the metaplastic phenotype and that alternative therapeutic approaches, including epigenetic therapies, may be required for metaplastic breast cancers. | 28424200 |
| Stomach Carcinoma | Epigenetic Alterations | We found first that miR-128 is down-regulated in gastric cancer cell lines and tissues, and this dysregulation is correlated with DNA methylation and the transcription factor SNAIL. | 28424413 |
| Thrombocytopenic purpura | Epigenetic Alterations | Altered microRNA (miRNA) expression has been reported in patients with immune thrombocytopenic purpura (ITP). | 28424819 |
| Thrombocytopenic purpura | Epigenetic Alterations | Plasma microRNAs characterising patients with immune thrombocytopenic purpura. | 28424819 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Accumulating evidence indicates that microRNAs are involved in glioma proliferation, invasion and drug resistance. | 28425046 |
| Cardiovascular Diseases | Epigenetic Alterations | Altered microRNA expression is implicated in cardiovascular diseases. | 28425970 |
| Aneurysm | Epigenetic Alterations | The data reveal microRNA expression signatures unique to aneurysm location and common to both thoracic and abdominal pathologies. | 28425970 |
| Vascular calcification | Epigenetic Alterations | Accumulating data suggest that microRNAs (miRs) play an important role in vascular calcification. | 28426428 |
| malignant disease | Epigenetic Alterations | Changes in DNA methylation in peripheral blood could be associated with malignant diseases. | 28426874 |
| Glioblastoma Multiforme | Epigenetic Alterations | This epigenetic silencing is a predictor of response to the alkylating drug temozolomide in glioblastoma. | 28427088 |
| Primary malignant neoplasm | Epigenetic Alterations | Interestingly, DBCCR1 attenuates the expression of DNMT1 (DNA methyltransferase 1), suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation. | 28427182 |
| Carcinoma of lung | Epigenetic Alterations | Our data thus implicates DBCCR1 downregulation as a potential module in the pathogenesis of lung cancer through DNA methylation. | 28427182 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Down-regulation of long non-coding RNA RP11-708H21.4 is associated with poor prognosis for colorectal cancer and promotes tumorigenesis through regulating AKT/mTOR pathway. | 28427191 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) serve critical roles in cancer development and progression. | 28427191 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-152 regulates immune response via targeting B7-H1 in gastric carcinoma. | 28427226 |
| Colonic adenomas, Primary malignant neoplasm | Epigenetic Alterations | Serum MicroRNA profile in patients with colon adenomas or cancer. | 28427387 |
| Malignant tumor of colon | Epigenetic Alterations | In these years, circulating microRNAs (miRNAs) have attracted increasing attention as novel biomarkers for colon cancers. | 28427387 |
| Adenoma, Primary malignant neoplasm, Colonic Polyps | Epigenetic Alterations | Five down-regulated miRNAs identified from Cancer versus Normal comparison were included in the list of DEMs identified from Adenomas versus Normal comparison, and may be important for the development of colon polyps and cancer. | 28427387 |
| Malignant tumor of colon, Colonic adenomas | Epigenetic Alterations | We discovered 8 circulating miRNAs associated with colon adenomas and colon cancer, and these miRNAs may potentially serve as noninvasive screening biomarkers for colon cancer. | 28427387 |
| Hypertensive (finding), Fibrosis Assessment | Epigenetic Alterations | Chronic administration of a DNA methylation inhibitor (ie, 5-Aza-2-deoxycitidine) improved ECG arrhythmic profiles and superoxide dismutase activities and reduced fibrosis in the left ventricle of spontaneously hypertensive rats. | 28427903 |
| Atrial arrhythmia, Atrial Fibrillation | Epigenetic Alterations | Taken together, these data support the notion that AF is associated with epigenetic changes in LA and provide a proof-of-concept that hypomethylating agents have to be considered in the treatment of atrial arrhythmias. | 28427903 |
| Malignant Neoplasms, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | It has been reported that microRNAs (miRNAs) are responsible for acquiring all the hallmarks of cancer cells, as well as have a significant impact on the clinical management of cancers at every stage, including prognosis, remission, relapse, and metastasis. | 28430523 |
| Cancer TNM Finding | Epigenetic Alterations | Altered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients Smoking Status. | 28430523 |
| Liquid Chromatography, Metastasis | Epigenetic Alterations | Our research contributed toward better elucidating the mechanisms underlying the progression of LC as well as the use of miRNAs inhibitors as novel agents against progression and metastasis of LC. | 28430523 |
| Clinical Coordinator | Epigenetic Alterations | Furthermore, overexpression of long noncoding RNA cardiac hypertrophy-related factor (lncRNA CHRF) was inversely correlated with miR-489 expression in CRC tissues. | 28430582 |
| Neoplasms | Epigenetic Alterations | microRNA-489 (miR-489) is a novel cancer-related miRNAs and functions as a tumor suppressor in human cancers. | 28430582 |
| Synucleinopathies | Epigenetic Alterations | We suggest that the regulation of SNCA expression through miRNAs is neuronal-type-specific and possibly plays a part in the phenotypic heterogeneity of synucleinopathies. | 28431219 |
| Neoplasms | Epigenetic Alterations | When comparing GAs by molecular pathway, GAs in tumor tissue were more common for the DNA repair and epigenetic pathways. | 28431395 |
| Neoplasms, ACTH-Secreting Pituitary Adenoma | Epigenetic Alterations | Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crookes cell morphology. | 28432562 |
| Crooke Cell Adenoma | Epigenetic Alterations | In addition, all four microRNAs from the miR-106b~25 cluster displayed marked upregulation in Crookes cell adenomas. | 28432562 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Profiling microRNA from nephrectomy and biopsy specimens: predictors of progression and survival in clear cell renal cell carcinoma. | 28432832 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | To identify microRNA (miRNA) characteristic of metastatic clear cell renal cell carcinoma (ccRCC) and those indicative of cancer-specific survival (CSS) in nephrectomy and biopsy specimens. | 28432832 |
| Intracranial Aneurysm | Epigenetic Alterations | DNA Methylation Regulates Gene Expression in Intracranial Aneurysms. | 28433851 |
| Intracranial Aneurysm | Epigenetic Alterations | In the development of intracranial aneurysms, DNA methylation plays an important role in the regulation of genetic expression involved in immune and inflammatory reactions, cell function, cell maintenance, and cell signal transduction. | 28433851 |
| Esophageal carcinoma | Epigenetic Alterations | Direct Downregulation of B-Cell Translocation Gene 3 by microRNA-93 Is Required for Desensitizing Esophageal Cancer to Radiotherapy. | 28434073 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | These data suggest a potential role of epigenetic machinery in mediating the anti-inflammatory effects of exercise in COPD patients. | 28435027 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | The severity of COPD was attenuated by miR-106b-5p, thus suggesting this miRNA as potential target for disease treatment. | 28435243 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Peripheral leukocyte microRNAs as novel biomarkers for COPD. | 28435243 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Compared to healthy controls, 19 differentially expressed miRNAs were found in COPD patients. | 28435243 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | For all COPD groups, miR-3177-3p was downregulated, while 17 miRNAs were upregulated. | 28435243 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Furthermore, the results revealed 21 differentially expressed miRNAs, of which miR-183-5p was continually downregulated from A to B to D. Between respective bronchodilator reversibility positive and negative groups of COPD different groups (A, B, C, and D), 10 miRNAs were differentially expressed, while miR-100-5p was upregulated in the negative groups. | 28435243 |
| Colorectal Cancer Pathway, Malignant neoplasm of esophagus, ibudilast, Inflammatory Bowel Diseases | Epigenetic Alterations | We also used quantitative reverse transcription PCR to validate the predicted expression levels of miRNAs in three diseases: inflammatory bowel disease (IBD), oesophageal cancer, and colorectal cancer. | 28436302 |
| CO-methylating acetyl-CoA synthase activity, Acute Coronary Syndrome | Epigenetic Alterations | Although circulating microRNA (miRNAs) have emerged as biomarkers predicting mortality in acute coronary syndrome (ACS), more data are needed to understand these mechanisms. | 28437675 |
| CO-methylating acetyl-CoA synthase activity | Epigenetic Alterations | Mapping miRNAs to high-risk traits may identify miRNAs involved in pathways conferring risk for poor outcome in ACS. | 28437675 |
| Aortic valve disorder | Epigenetic Alterations | These novel findings indicate that modulation of the epigenetic mechanism underlying valvular pro-osteogenic activity has therapeutic potential for prevention of calcific aortic valve disease progression. | 28438736 |
| Malignant Neoplasms, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Hypermethylation of miRNA-589 promoter leads to upregulation of HDAC5 which promotes malignancy in non-small cell lung cancer. | 28440397 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | MicroRNA-26a inhibits proliferation and metastasis of human hepatocellular carcinoma by regulating DNMT3B-MEG3 axis. | 28440439 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | Altered microRNA (miRNA) expression has been reported to participate in the pathogenesis of several human diseases, and particularly cancer. | 28440476 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Genome-wide DNA methylation sequencing reveals miR-663a is a novel epimutation candidate in CIMP-high endometrial cancer. | 28440489 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant DNA methylation is widely observed in many cancers. | 28440489 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | Concurrent DNA methylation of multiple genes occurs in endometrial cancer and is referred to as the CpG island methylator phenotype (CIMP). | 28440489 |
| Primary malignant neoplasm | Epigenetic Alterations | We then selected two samples each from CIMP-H and CIMP(-) classes, and analyzed DNA methylation status of both normal (peripheral blood cells: PBCs) and cancer tissues by genome-wide, targeted bisulfite sequencing. | 28440489 |
| Malignant neoplasm of endometrium, Primary malignant neoplasm | Epigenetic Alterations | This is the first report showing that aberrant DNA methylation of the miR-663a promoter can occur in normal tissue of the cancer patients, suggesting a possible link between this epigenetic abnormality and endometrial cancer. | 28440489 |
| Endometrial Carcinoma | Epigenetic Alterations | This raises the possibility that the hypermethylation of the miR-663a promoter represents an epimutation associated with the CIMP-H endometrial cancers. | 28440489 |
| Acute leukemia | Epigenetic Alterations | Relationship between epigenetic changes in Wnt antagonists and acute leukemia. | 28440495 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Accumulating evidence shows that mircroRNAs (miRNAs) play a crucial role in the development of colorectal cancer. | 28440497 |
| Cerebral Infarction, Subarachnoid Hemorrhage, Aneurysmal | Epigenetic Alterations | Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage. | 28442458 |
| Malignant Neoplasms, Carcinoma of lung | Epigenetic Alterations | Accumulating evidence indicates that abnormal expression of long non-coding RNAs is associated with tumorigenesis in multiple cancers, including lung cancer. | 28443464 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-140-5p inhibits cell proliferation and invasion by regulating VEGFA/MMP2 signaling in glioma. | 28443475 |
| Nasopharyngeal carcinoma, Malignant neoplasm of liver | Epigenetic Alterations | Long Noncoding RNA Highly Upregulated in Liver Cancer Activates p53-p21 Pathway and Promotes Nasopharyngeal Carcinoma Cell Growth. | 28445086 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | The HDAC inhibitor valproate induces a bivalent status of the CD20 promoter in CLL patients suggesting distinct epigenetic regulation of CD20 expression in CLL in vivo. | 28445158 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in the cancer development and progression; overexpression of miR-103 has been identified in various tumors. | 28445396 |
| Primary malignant neoplasm | Epigenetic Alterations | Emerging studies indicated that long non-coding RNAs (lncRNAs) play crucial roles in cancer biology. | 28445936 |
| Neoplasms, Retinoblastoma, Childhood Medulloblastoma, Glioblastoma Multiforme, Neuroblastoma, cervical cancer | Epigenetic Alterations | Expression of this miRNA generally increases with cell differentiation whereas it is downregulated in several types of tumors, such as breast, lung, ovarian, gastric, colon, and cervical cancers, neuroblastoma, medulloblastoma, glioblastoma, and retinoblastoma. | 28445974 |
| Herpes | Epigenetic Alterations | Thyroid hormone (TH) has been suggested to control herpes virus gene expression and replication in neurons via epigenetics through its nuclear receptors. | 28450196 |
| Myeloid neoplasm | Epigenetic Alterations | Epigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignancies. | 28452111 |
| Myeloid Leukemia | Epigenetic Alterations | Epigenetic studies showed that ID4 methylation might be one of the mechanisms silencing ID4 expression in myeloid leukaemia. | 28452111 |
| Antilymphocyte Serum | Epigenetic Alterations | A continued change in miRNA expression persisted during disease progression indicating the potential use of these particular miRNAs as longitudinal biomarkers in ALS. | 28454844 |
| Neurodegenerative Disorders | Epigenetic Alterations | As regulators of gene expression, microRNAs (miRNAs) are increasingly used for diagnostic and prognostic purposes in various disease states with increasing exploration in neurodegenerative disorders. | 28454844 |
| Antilymphocyte Serum, Amyotrophic Lateral Sclerosis | Epigenetic Alterations | Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS). | 28454844 |
| Primary malignant neoplasm | Epigenetic Alterations | We demonstrate that epigenetic regulation of OPRM1 contributes to opioid tolerance in cancer patients, and that targeted gene therapy could treat cancer-induced nociception and opioid tolerance in a mouse cancer model. | 28456745 |
| cervical cancer | Epigenetic Alterations | Our objective was to analyse the influence of (1) methylation within two immunostimulatory CpG motifs within HPV16 E6 and E7 genes around the viral late promoter and their correlation, if any, with expression deregulation of host receptor (TLR9) and DNA methyltransferases (DNMT1, DNMT3A and DNMT3B) and (2) global DNA methylation levels within CpGs of the repetitive Alu sequences, on cervical cancer (CaCx) pathogenesis. | 28459195 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic alterations within human papillomavirus (HPV) and host cellular genomes are known to occur during cervical carcinogenesis. | 28459195 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | The long noncoding RNA urothelial carcinoma-associated 1 overexpression as a poor prognostic biomarker in clear cell renal cell carcinoma. | 28459210 |
| Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNA urothelial carcinoma-associated 1 has previously played important roles in cancer. | 28459210 |
| Northeast, Esophageal carcinoma | Epigenetic Alterations | We hypothesized that in addition to currently known environmental risk factors for esophageal cancer, genetic and epigenetic factors are also involved in esophageal carcinogenesis in Northeast India. | 28459370 |
| Esophageal carcinoma | Epigenetic Alterations | This study reveals a synergistic interaction between epigenetic, genetic, and environmental factors and risk of esophageal cancer in this high-incidence region of Northeast India. | 28459370 |
| Medical Device Material Rupture, Intracranial Aneurysm | Epigenetic Alterations | We compared circulating microRNA (miRNA) levels in plasma of patients with intracranial aneurysms (IA) to those of controls as a first step towards finding potential biomarkers for individuals at high risk of IA development and its subsequent rupture. | 28459827 |
| Intracranial Aneurysm | Epigenetic Alterations | Circulating microRNAs in patients with intracranial aneurysms. | 28459827 |
| Malignant Neoplasms, Prostate Cancer Pathway | Epigenetic Alterations | Chromosome 8q24 has emerged as an important genetic susceptibility region for several cancers, including prostate cancer; however, little is known about the contribution of DNA methylation in this region to risk. | 28463958 |
| Prostate Cancer Pathway | Epigenetic Alterations | Although requiring replication, our findings provide some evidence that 8q24 DNA methylation levels may be associated with prostate cancer risk. | 28463958 |
| Metastasis, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Genome-wide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma. | 28465481 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | However, there are few DNA methylation markers able to predict the presence of LNM in ESCC. | 28465481 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | In this screening, we focused on differentially methylated regions (DMRs) that were associated with LNM of ESCC, as prime candidates for DNA methylation markers. | 28465481 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | These results suggested that HOXB2 and SEPT9 may be useful epigenetic biomarkers for the prediction of the presence of LNM in ESCC. | 28465481 |
| Adenocarcinoma of pancreas | Epigenetic Alterations | Evaluation of Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Adenocarcinoma: miR-196a and miR-210 Could Be Negative and Positive Prognostic Markers, Respectively. | 28466015 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | miRNA regulation is important for DNA damage repair and recognition in malignant pleural mesothelioma. | 28466156 |
| Neoplasms | Epigenetic Alterations | Twenty-four formalin-fixed, paraffin-embedded (FFPE) tumour specimens were subjected to a miRNA expression screening of 800 important miRNAs using digital quantification via the nCounter technique (NanoString). | 28466156 |
| Neoplasms | Epigenetic Alterations | The long non-coding RNA urothelial carcinoma-associated 1 is reportedly upregulated and functions as an oncogene in some tumors. | 28466784 |
| Malignant Neoplasms | Epigenetic Alterations | Long non-coding RNAs have recently emerged as important regulators in the pathogenesis and progression of cancers. | 28466784 |
| melanoma | Epigenetic Alterations | Identification of plasma microRNAs as new potential biomarkers with high diagnostic power in human cutaneous melanoma. | 28466785 |
| Carcinoma of lung, Herpes Simplex Infections, Metastasis, Neoplasms | Epigenetic Alterations | A herpes simplex virus type 2-encoded microRNA promotes tumor cell metastasis by targeting suppressor of cytokine signaling 2 in lung cancer. | 28468588 |
| Carcinoma of lung, Malignant neoplasm of lung, Metastasis, Neoplasms | Epigenetic Alterations | However, whether these microRNAs play a role in the metastasis of lung cancers and how these viral microRNAs precisely regulated the tumor biological process in lung cancer bone metastasis remain obscure. | 28468588 |
| Neoplasms | Epigenetic Alterations | A similar integrative analysis uncovered 40 of 254 differentially expressed genes, which are potentially regulated by DNA methylation in BRAFV600E-positive tumors. | 28469731 |
| BRAF NP_004324.2:p.V600E, Neoplasms, F9 gene | Epigenetic Alterations | DNA methylation loss in non-promoter, poor CGI and enhancer-enriched regions was a significant event in PTC, especially in tumors harboring BRAFV600E. | 28469731 |
| F9 gene | Epigenetic Alterations | The integrative analysis revealed genes potentially regulated by DNA methylation pointing out potential drivers and biomarkers related to PTC development. | 28469731 |
| Degenerative polyarthritis, Rheumatoid Arthritis, Right arm | Epigenetic Alterations | DNA methylation profiling of articular chondrocytes from OA patients, rheumatoid arthritis (RA) patients, and controls was performed, and candidate genes were chosen for validation of gene demethylation status. | 28470428 |
| Degenerative polyarthritis | Epigenetic Alterations | It is the first time to show that TRAF1, CTGF, and CX3CL1 genes were hypomethylated in OA chondrocytes and have a consistent correlation with mRNA expression, which suggests that epigenetic changes in the methylation status of TRAF1, CTGF, and CX3CL1 contribute to the pathology of OA. | 28470428 |
| Sjogrens Syndrome", Perceived stress scale | Epigenetic Alterations | We described earlier a simultaneously increased that the increased expression of miRNA-146a/b was accompanied by an increase in the expression of and TRAF6 and a decrease in the expression of IRAK1 genes in the peripheral mononuclear cells (PBMCs) of patients with primary Sjogrens syndrome (pSS) patients. | 28470929 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | Plasmatic extracellular vesicle microRNAs in malignant pleural mesothelioma and asbestos-exposed subjects suggest a 2-miRNA signature as potential biomarker of disease. | 28472171 |
| Malignant Neoplasms, Disease | Epigenetic Alterations | Changes in miRNA expression have been implicated in several diseases and cancers, including MPM. | 28472171 |
| Malignant Pleural Mesothelioma | Epigenetic Alterations | We examined if a specific miRNA signature in plasmatic extracellular vesicles (EV) may help to discriminate between malignant pleural mesothelioma patients (MPM) and subjects with Past Asbestos Exposure (PAE). | 28472171 |
| Disease | Epigenetic Alterations | To elucidate lncRNA function in human disease, we have developed a novel network based method (NLCFA) integrating correlations between lncRNA, protein coding genes and noncoding miRNAs. | 28472271 |
| Stomach Carcinoma | Epigenetic Alterations | Knockdown of long non-coding RNA HOXD-AS1 inhibits gastric cancer cell growth via inactivating the JAK2/STAT3 pathway. | 28475004 |
| Neoplasms | Epigenetic Alterations | Long non-coding RNA HOXD-AS1 (HOXD cluster antisense RNA 1) has been demonstrated to be closely associated with the progression of several tumors. | 28475004 |
| Malignant Neoplasms | Epigenetic Alterations | Colon cancer-associated transcript 1 (CCAT1), a long non-coding RNA (lncRNA), is upregulated and has a vital role in the pathogenesis of numerous cancers. | 28475287 |
| Hepatitis B, Fibrosis, Liver | Epigenetic Alterations | Serum microRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein are useful tools for liquid biopsy of the patients with hepatitis B virus and advanced liver fibrosis. | 28475652 |
| Right arm | Epigenetic Alterations | Epigenetic regulation of immune cell types could be critical for the development and maintenance of autoimmune diseases like rheumatoid arthritis (RA). | 28475762 |
| Neoplasms | Epigenetic Alterations | This microRNA also induced apoptosis of hepatoma cells and blocked tumor growth in vivo in the chick chorioallantoic membrane model. | 28476031 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | We provided strong molecular, cellular and in vivo evidences for the tumor suppressive activities of miR-4510 bringing to the fore the potential value of this microRNA in HCC therapy. | 28476031 |
| Malignant neoplasm of liver, Neoplasms | Epigenetic Alterations | New tumor suppressor microRNAs target glypican-3 in human liver cancer. | 28476031 |
| Neoplasms | Epigenetic Alterations | These 5 microRNAs were significantly downregulated in tumoral compared to non-tumoral liver and inhibited tumor cell proliferation. | 28476031 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer. | 28476123 |
| Clinical Coordinator, Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Epigenetic down regulation of GPER acts as a tumor suppressor in colorectal cancer and its specific activation might be a potential approach for CRC treatment. | 28476123 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Research on the epigenetic regulation mechanism of the PTPN6 gene in advanced chronic myeloid leukaemia. | 28480959 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | However, epigenetic regulation mechanism of the PTPN6 gene in advanced chronic myeloid leukaemia (CML) remains unclear. | 28480959 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Recently, miRNAs have been investigated in the most cancer researches which have demonstrated that they have been dysregulated in many cancers. | 28482669 |
| Breast Carcinoma | Epigenetic Alterations | This study provides evidence that circRNAs are differentially expressed in breast cancer and are important in carcinogenesis because they participate in cancer-related pathways and sequester miRNAs. | 28484086 |
| Heart failure | Epigenetic Alterations | Epigenetic mechanisms, such as microRNA, histone modification, and DNA methylation, are critical for dysregulated gene expression in heart failure (HF). | 28485796 |
| Malignant neoplasm of stomach stage IV | Epigenetic Alterations | MicroRNA-217 suppressed epithelial-to-mesenchymal transition in gastric cancer metastasis through targeting PTPN14. | 28485805 |
| Hyperglycemia | Epigenetic Alterations | This suggests that consequences of in utero exposure to maternal hyperglycemia extend beyond the fetal development, possibly through epigenetic programming. | 28486003 |
| Malignant Neoplasms | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) are crucial regulators in many human cancers, yet their potential roles and molecular mechanisms in CRPC are poorly understood. | 28487115 |
| Metastasis, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) have important roles in the development, invasion, and metastasis of various tumors, including HSCC, but little is known about the role of lncRNAs in cancer radioresistance. | 28487500 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-1 acts as a tumor suppressor microRNA by inhibiting angiogenesis-related growth factors in human gastric cancer. | 28493075 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | We recently reported that miR-1 was one of the most significantly downregulated microRNAs in gastric cancer (GC) patients from The Cancer Genome Atlas microRNA sequencing data. | 28493075 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Minimal residual disease eradication with epigenetic therapy in core binding factor acute myeloid leukemia. | 28494506 |
| Atrial Fibrillation, Fibrosis Assessment | Epigenetic Alterations | MicroRNA-21 via Dysregulation of WW Domain-Containing Protein 1 Regulate Atrial Fibrosis in Atrial Fibrillation. | 28495464 |
| Neoplasms | Epigenetic Alterations | Recent evidence highlights the crucial regulatory roles of long non-coding RNAs (lncRNA) in tumor biology. | 28495512 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Circulating plasma microRNAs as potential markers to identify EGFR mutation status and to monitor epidermal growth factor receptor-tyrosine kinase inhibitor treatment in patients with advanced non-small cell lung cancer. | 28496005 |
| Pulmonary arterial hypertension | Epigenetic Alterations | Pri-microRNA-124 rs531564 polymorphism minor allele increases the risk of pulmonary artery hypertension by abnormally enhancing proliferation of pulmonary artery smooth muscle cells. | 28496318 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-15b promotes proliferation and invasion of non-small cell lung carcinoma cells by directly targeting TIMP2. | 28498424 |
| Neoplasms | Epigenetic Alterations | MicroRNA-15b (miR-15b) plays an important role in tumor development and progression. | 28498424 |
| Carcinoma of lung | Epigenetic Alterations | Then, miRNA-mRNA regulatory network was constructed to identify miRNA candidates associated with lung cancer through integrating gene expression and miRNA-target prediction. | 28498428 |
| Carcinoma of lung | Epigenetic Alterations | Furthermore, the expression levels of miRNA candidates were validated by stem-loop real-time reverse transcription PCR (qRT-PCR) in larger lung cancer population. | 28498428 |
| Carcinoma of lung | Epigenetic Alterations | Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of lung cancer. | 28498428 |
| Primary malignant neoplasm | Epigenetic Alterations | Tumor-specific microRNAs (miRNAs) seem to be potential biomarkers for the early diagnosis and treatment of cancer. | 28498428 |
| Carcinoma of lung | Epigenetic Alterations | Therefore, there are a set of signature miRNAs which may be promising biomarkers for the early screening of high-risk populations and early diagnosis of lung cancer. | 28498428 |
| SERPINB3 wt Allele | Epigenetic Alterations | Prognostic significance of altered miRNA expression in whole blood of OSCC patients. | 28498442 |
| Malignant Neoplasms | Epigenetic Alterations | A cut-off point (COP) for the discrimination between the R-OC and NR-OC groups was calculated and the significance between over/under expression of the miRNAs and the recurrence of malignancy was determined. | 28498442 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | A recent study reported that the levels of miR-944 in recurrent CRC patients were evidently lower than that in non-recurrent cases, suggesting that miR-944 may function as a tumor suppressive miRNA in CRC. | 28498456 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Dysfunction of microRNAs (miRNAs) is strongly proved to participate in the pathogenesis and tumorigenicity of colorectal cancer (CRC). | 28498456 |
| Metastasis, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma. | 28498804 |
| Adenocarcinoma, Metastasis | Epigenetic Alterations | Both DNA methylation levels over -423 and -248 CpG sites of the S100A15 gene promoter were decreased in adenocarcinoma patients with distant metastasis, and the former was associated with lower one-year overall survival. | 28498804 |
| Metastasis, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Increased S100A15 expression and decreased DNA methylation of its gene promoter region were associated with high metastasis potential and poor outcome in lung adenocarcinoma, probably through triggering CTNNB1 -centered pathways. | 28498804 |
| Cervical dysplasia, Primary malignant neoplasm | Epigenetic Alterations | Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer. | 28500655 |
| Clinical Coordinator, Colorectal Cancer Pathway, Malignant Neoplasms | Epigenetic Alterations | Colorectal cancer (CRC) is one of the most common cancers worldwide and, although the majority of cases are sporadic, its development and progression depends on a range of factors: environmental, genetic and epigenetic. | 28504867 |
| Damage | Epigenetic Alterations | Although increasing evidence suggests that estrogen receptor a (ESRa) genetic variation could modify bone damage caused by environmental fluoride exposure, little is known about epigenetic mechanisms in relation to bone changes. | 28505433 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MiR-424 functions as a tumor suppressor in glioma cells and is down-regulated by DNA methylation. | 28508328 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | In addition, based on DNA methylation analysis on clinical specimens and cell lines, we found miR-424 promoter CpG island was frequently methylated and correlated with glioma high grades (P = 0.035) and IDH mutation status (P = 0.042). | 28508328 |
| Malignant Neoplasms, Glioma, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Glioma is one of the most lethal malignancies, and increasing reports revealed that microRNAs (miRNAs), a class of small non-coding RNAs, play a critical role in the development and pathology of human gliomas. | 28508328 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Literature review enabled identification of 10 microRNAs associated with oral and head and neck malignancies. | 28512746 |
| Allergic asthma | Epigenetic Alterations | Identification of a plasma miRNA biomarker signature for allergic asthma: A translational approach. | 28513859 |
| Asthma Pathway | Epigenetic Alterations | Thus, we suggest that miRNA levels in plasma might have future potential to subphenotype patients with asthma. | 28513859 |
| Asthma Pathway | Epigenetic Alterations | Candidate miRNAs were then validated in a second, independent group of 26 asthma patients and 12 healthy controls. | 28513859 |
| Allergic asthma | Epigenetic Alterations | Distinct plasma miRNAs are differentially regulated both in murine and in human allergic asthma and were associated with clinical characteristics of patients. | 28513859 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Circulating microRNAs as novel biomarkers of ALK-positive nonsmall cell lung cancer and predictors of response to crizotinib therapy. | 28514730 |
| ALK Positive, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Plasma levels of 21 microRNAs were differentially expressed for ALK-positive and ALK-negative NSCLC, including 14 down-regulated and 7 up-regulated microRNAs. | 28514730 |
| ALK Positive, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Candidate microRNAs in plasma from ALK-positive (n = 41) and ALK-negative NSCLC patients (n = 32) were quantified using real-time reverse transcriptase quantitative polymerase chain reaction. | 28514730 |
| ALK Positive, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Thus, in this preliminary investigation, we identified a potential panel of 3 microRNAs for distinguishing between patients with ALK-positive and ALK-negative NSCLC. | 28514730 |
| Intervertebral Disc Degeneration | Epigenetic Alterations | Inflammatory microRNA-194 and -515 attenuate the biosynthesis of chondroitin sulfate during human intervertebral disc degeneration. | 28514734 |
| Intervertebral disc disorder, Intervertebral Disc Degeneration | Epigenetic Alterations | These findings together demonstrated a vital role of inflammatory stimulated microRNAs in promoting intervertebral disc degeneration by interrupt chondroitin sulfate synthesis, which may provide new insights into the mechanism and therapeutic approaches in IDD. | 28514734 |
| Hollings Cancer Center | Epigenetic Alterations | An innovative analytical approach has been adopted to identify Stochastic Epigenetic Mutations (SEMs) in HCC.HCC and peritumoral tissues showed a different epigenetic profile, mainly characterized by loss of DNA methylation in HCC. | 28514750 |
| Liver carcinoma | Epigenetic Alterations | Epigenome-wide association study in hepatocellular carcinoma: Identification of stochastic epigenetic mutations through an innovative statistical approach. | 28514750 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Hepatocellular carcinoma (HCC) results from accumulation of both genetic and epigenetic alterations. | 28514750 |
| Clinical Coordinator | Epigenetic Alterations | Levels of 12 epigenetic cf-nucleosome epitopes were measured in the sera of 58 individuals referred for endoscopic screening for CRC. | 28515797 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-23b functions as an oncogene and activates AKT/GSK3b/b-catenin signaling by targeting ST7L in hepatocellular carcinoma. | 28518144 |
| Hollings Cancer Center | Epigenetic Alterations | In the past few years, many microRNAs (miRNAs) have been proved to have important roles in tumorigenesis of HCC. | 28518144 |
| Vascular calcification | Epigenetic Alterations | Circulating MicroRNA-125b Predicts the Presence and Progression of Uremic Vascular Calcification. | 28522697 |
| Hyperphosphatemia (disorder) | Epigenetic Alterations | We identified circulating, cell-free microRNAs as potential biomarkers using in vitro VC models in which both rat and human aortic vascular smooth muscle cells were treated with high levels of phosphate to mimic uremic hyperphosphatemia. | 28522697 |
| ovarian neoplasm | Epigenetic Alterations | These findings suggest that GABRP enhances the aggressive phenotype of ovarian cancer cells, and that the DNA methylation status of the GABRP -963 CpG site may be useful for predicting the metastatic potential in ovarian cancer patients. | 28524180 |
| ovarian neoplasm | Epigenetic Alterations | Aberrant epigenetic regulation of GABRP associates with aggressive phenotype of ovarian cancer. | 28524180 |
| Primary malignant neoplasm | Epigenetic Alterations | Detection of Promoter DNA Methylation of APC, DAPK, and GSTP1 Genes in tissue Biopsy and Matched Serum of Advanced-Stage Lung Cancer Patients. | 28524770 |
| Breast Carcinoma | Epigenetic Alterations | DNA methylation mediated silencing of microRNA-874 is a promising diagnosis and prognostic marker in breast cancer. | 28525377 |
| Breast Carcinoma | Epigenetic Alterations | The DNA methylation status of the miR-874 promoter region in 19 pairs of breast cancer and adjacent normal samples was analyzed with Sequenom EpiTYPER MassArray. | 28525377 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MicroRNA-874 (miR-874) is downregulated in several human cancers and has been suggested to be a tumor suppressor gene. | 28525377 |
| Primary malignant neoplasm | Epigenetic Alterations | Thus, DNA methylation is thought to provide potential biomarkers for assessment of cancer risk in normal mucosa. | 28533824 |
| Clinical Coordinator | Epigenetic Alterations | DNA methylation levels in SFRP1 and SFRP2 genes in normal crypts were significantly higher in left-side than right-side CRC with an MSS phenotype. | 28533824 |
| Primary malignant neoplasm | Epigenetic Alterations | Our results showed that DNA methylation of SFRP1 and SFRP2 might be useful to predict cancer risk of surrounding normal mucosa. | 28533824 |
| Hypertensive disease | Epigenetic Alterations | In summary, hsa-circ-0005870 may represent a novel biomarker for the diagnosis of hypertension, and hsa-circ-0005870-miRNA-mRNA network may provide potential mechanism for hypertension. | 28534714 |
| MIRN-5095 microRNA, human | Epigenetic Alterations | Then, we constructed a network of hsa-circ-0005870-targeted miRNAs, including hsa-miR-6807-3p, hsa-miR-5095, hsa-miR-1273g-3p, hsa-miR-5096, hsa-miR-619-5p, and their corresponding mRNAs. | 28534714 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | Analysis of our microRNA (miRNA) expression signature in human cancers has shown that guide and passenger strands of pre-miR-150, i.e., miR-150-5p and miR-150-3p, are significantly downregulated in cancer tissues. | 28534948 |
| CHOANAL ATRESIA, POSTERIOR, Hormone refractory prostate cancer, Primary malignant neoplasm | Epigenetic Alterations | Novel approaches to analysis of antitumor miRNA-regulated RNA networks in cancer cells may provide new insights into the pathogenic mechanisms of naive PCa and CRPC. | 28534948 |
| Prostate Cancer Pathway | Epigenetic Alterations | Dual strands of pre-miR-150 (miR-150-5p and miR-150-3p) act as antitumor miRNAs targeting SPOCK1 in naive and castration-resistant prostate cancer. | 28534948 |
| Primary malignant neoplasm | Epigenetic Alterations | Ectopic expression assays showed that both strands of miRNAs significantly suppressed cancer cell migration and invasion. | 28534948 |
| CHOANAL ATRESIA, POSTERIOR, Hormone refractory prostate cancer | Epigenetic Alterations | Taken together, dual strands of pre-miR-150 (miR-150-5p and miR-150-3p) acted as antitumor miRNAs in naive PCa and CRPC cells. | 28534948 |
| Pancreatic carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-296 targets AKT2 in pancreatic cancer and functions as a potential tumor suppressor. | 28534950 |
| Pancreatic carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Although microRNA-296 (miR-296) has been studied in various types of human cancer, its expression, biological role and mechanism of action in pancreatic cancer remains to be elucidated. | 28534950 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA-200c regulates cisplatin resistance by targeting ZEB2 in human gastric cancer cells. | 28534959 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Altered microRNA (miRNA or miR) expression has been reported in chronic obstructive pulmonary disease (COPD). | 28534971 |
| Breast Cancer Cell | Epigenetic Alterations | Previous studies have suggested that dysregulation of microRNA (miR) -124a is associated with various types of human cancer. | 28534972 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1. | 28535543 |
| Neoplasms | Epigenetic Alterations | MicroRNA-181a-5p (miR-181a-5p) acts as a tumor suppressor which can regulate target gene at the posttranscriptional level. | 28535543 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNAs are reported to play key roles in regulating the main risk factors for osteoarthritis (OA) chondrogenesis. | 28537665 |
| Clinical Coordinator | Epigenetic Alterations | This is the first report of significant combined and interactive effects between dietary factors and polymorphisms in the microRNA binding site of IL13 in CRC and may provide direct guidance on intake of allium vegetable and overnight meals for individuals with specific genetic variants of IL13 to modify their susceptibility to CRC. | 28537887 |
| Primary malignant neoplasm | Epigenetic Alterations | Increasing evidence supports that microRNA (miRNA)-mediated gene regulation plays a significant functional role in cancer progression. | 28537888 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer. | 28538837 |
| Neoplasms | Epigenetic Alterations | Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), has tumor-suppressor properties and its expression is lost in several human tumors. | 28539329 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | Overexpression of long intergenic noncoding RNA LINC00312 inhibits the invasion and migration of thyroid cancer cells by down-regulating microRNA-197-3p. | 28539331 |
| Neoplasms | Epigenetic Alterations | These microRNAs may serve as potentially early biomarker and act as tumor suppressor genes. | 28539816 |
| Anxiety, CTCAE 5.0 | Epigenetic Alterations | Epigenetic regulation in anxiety is suggested, but evidence from large studies is needed. | 28540928 |
| Breast Carcinoma | Epigenetic Alterations | Low Expression of Circulating MicroRNA-34c is Associated with Poor Prognosis in Triple-Negative Breast Cancer. | 28540980 |
| Neoplasms | Epigenetic Alterations | The microRNA-34 (miR-34) family is important in tumor regulation. | 28540980 |
| diabetic | Epigenetic Alterations | Differential DNA methylation of MSI2 and its correlation with diabetic traits. | 28542303 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Epigenetic Alterations | Differential DNA methylation with hyperglycemia is significantly associated with Type 2 Diabetes (T2D). | 28542303 |
| Hyperglycemia | Epigenetic Alterations | However, the relevance of the differential DNA methylation changes with hyperglycemia in blood with pancreatic islets remains unclear. | 28542303 |
| Hyperglycemia | Epigenetic Alterations | Our findings suggest that epigenetic perturbation on the target site of MSI2 gene in circulating blood and pancreatic islets should represent or affect hyperglycemia. | 28542303 |
| Multiple Myeloma | Epigenetic Alterations | Deregulated expression of long non-coding RNA UCA1 in multiple myeloma. | 28543758 |
| Breast Carcinoma | Epigenetic Alterations | Long non-coding RNA HOXA-AS2 promotes proliferation and invasion of breast cancer by acting as a miR-520c-3p sponge. | 28545023 |
| Malignant Neoplasms | Epigenetic Alterations | The long non-coding RNA (lncRNA) HOXA cluster antisense RNA2 (HOXA-AS2) has recently been shown to be dysregulated and involved in the progression of several cancers. | 28545023 |
| Papillary thyroid carcinoma | Epigenetic Alterations | Identification of novel long non-coding RNA biomarkers for prognosis prediction of papillary thyroid cancer. | 28545026 |
| Non-Malignant Nodule, Pathological accumulation of air in tissues | Epigenetic Alterations | Age, smoking status, nodule diameter, history of emphysema, vascular sign, burr sign, CYFRA21-1, CEA, miRNA-21-5p, and miRNA-574-5p differed significantly between the benign and malignant nodule groups. | 28545454 |
| Graves Disease, Atrial Fibrillation | Epigenetic Alterations | Circulating microRNA-1a is a biomarker of Graves disease patients with atrial fibrillation. | 28547036 |
| Atrial Fibrillation | Epigenetic Alterations | It has been increasingly suggested that specific microRNAs expression profiles in the circulation and atrial tissue are associated with the susceptibility to atrial fibrillation. | 28547036 |
| Atrial Fibrillation, Graves Disease | Epigenetic Alterations | The expression profiles of eight serum microRNAs, which are found to be critical in the pathogenesis of atrial fibrillation, were determined in patients with Graves disease with or without atrial fibrillation. | 28547036 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype. | 28548123 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | We have previously shown that commonly expressed miRNAs influenced tumor molecular phenotype in colorectal cancer. | 28548123 |
| Neoplasms | Epigenetic Alterations | We hypothesize that infrequently expressed miRNAs, when showing higher levels of expression, help to define tumor molecular phenotype. | 28548123 |
| Neoplasms | Epigenetic Alterations | We compare miRNAs uniquely associated with tumor molecular phenotype to the RNAseq data to identify genes associated with these miRNAs. | 28548123 |
| Neoplasms | Epigenetic Alterations | Of the 34 miRNAs associated with CpG island methylator phenotype-high tumors, 16 were more likely to have a CpG island methylator phenotype-high tumor and 19 were less likely to be CpG island methylator phenotype-high. | 28548123 |
| Neoplasms | Epigenetic Alterations | For microsatellite instability, 13 of the 22 infrequently expressed miRNAs were significantly less likely to be expressed in microsatellite unstable tumors. | 28548123 |
| Neoplasms | Epigenetic Alterations | Of the dysregulated miRNAs, 17 were more likely to be TP53-mutated tumors while simultaneously being less likely to be CpG island methylator phenotype-high and/or microsatellite instability tumors. | 28548123 |
| Primary malignant neoplasm | Epigenetic Alterations | Genes regulated by these miRNAs were involved in numerous functions and pathways that influence cancer risk and progression. | 28548123 |
| Neoplasms | Epigenetic Alterations | In summary, some infrequently expressed miRNAs, when expressed at higher levels, appear to have significant biological meaning in terms of tumor molecular phenotype and gene expression profiles. | 28548123 |
| Malignant tumor of colon | Epigenetic Alterations | MicroRNA-186-5p overexpression modulates colon cancer growth by repressing the expression of the FAM134B tumour inhibitor. | 28549913 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Several miRNAs have been reported to be associated with PCa. | 28551819 |
| Malignant tumor of colon | Epigenetic Alterations | MicroRNA-200b is downregulated in colon cancer budding cells. | 28552992 |
| Coronary Artery Disease | Epigenetic Alterations | Association between circulating microRNA-208a and severity of coronary heart disease. | 28554251 |
| Myocardium | Epigenetic Alterations | Circulating microRNA (miR)-208a is specifically expressed in the heart muscle, which is involved in the regulation of myosin during cardiac development. | 28554251 |
| Choline Dehydrogenase, Mitochondrial | Epigenetic Alterations | CHD patients had higher miRNA-208a expression (1.61, 0.45-3.86 vs. 0.66, 0.11-1.42, p < .001), and the biomarker level significantly increased following an increasing the Gensini score (p < .001). | 28554251 |
| Rectal Carcinoma | Epigenetic Alterations | Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy. | 28554991 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNAs are promising candidates, however analyses of circulating microRNAs in rectal cancer are still rare. | 28554991 |
| Carcinogenesis, Helicobacter pylori | Epigenetic Alterations | Residual DNA methylation in the gastric mucosa after Helicobacter pylori (H. pylori) eradication may have a role in gastric carcinogenesis. | 28557342 |
| Intestinal metaplasia | Epigenetic Alterations | The atrophic type by the magnifying NBI and presence of intestinal metaplasia are the morphologic characteristics of residual DNA methylation of after H. pylori eradication, regardless of the post-eradication period and it might be considered as the epigenetic irreversible point with H. pylori eradication. | 28557342 |
| Neoplasms | Epigenetic Alterations | Specifically, localised and systemic biochemical alterations produced during and following exercise may suppress tumour formation, growth and distribution by virtue of altered epigenetics and endocrine-paracrine activity. | 28559456 |
| Prostate Cancer Pathway | Epigenetic Alterations | Effects of genistein supplementation on genome-wide DNA methylation and gene expression in patients with localized prostate cancer. | 28560383 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-526a targets p21-activated kinase 7 to inhibit tumorigenesis in hepatocellular carcinoma. | 28560394 |
| Plaque, Atherosclerotic | Epigenetic Alterations | microRNAs (miRNAs) serve significant roles in the pathophysiology of atherosclerotic plaque progression. | 28560417 |
| Malignant Neoplasms, Carcinogenesis | Epigenetic Alterations | MicroRNAs are a class of small noncoding RNA molecules, which play important roles in diverse biological processes of human cancers, such as carcinogenesis, development, differentiation, and apoptosis. | 28560419 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer. | 28562349 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA (miR)-155 is upregulated in breast cancer cells and in sera of patients with breast cancer, but its clinical relevance remains uncertain. | 28562349 |
| Stomach Carcinoma | Epigenetic Alterations | The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer. | 28562634 |
| Hepatobiliary Disorder, Hepatitis, Chronic | Epigenetic Alterations | Circulating microRNA as a marker for predicting liver disease progression in patients with chronic hepatitis B. | 28562750 |
| Complete atrioventricular block | Epigenetic Alterations | We compared microRNA expression profiles between CHB with and without cirrhosis/HCC to discover possible prognostic markers associated with the progression of CHB. | 28562750 |
| Complete atrioventricular block | Epigenetic Alterations | Our results indicated 8 differently expressed microRNAs, of which miRNA-935, miRNA-342, miRNA-339, miRNA-4508, miRNA-3615, and miRNA-3200 were up-regulated, whereas miRNA-182 and miRNA-4485 were down-regulated in patients with CHB who progressed to cirrhosis/HCC as compared to those without progression. | 28562750 |
| Liver Cirrhosis, Hollings Cancer Center | Epigenetic Alterations | These miRNAs may serve as novel and non-invasive prognostic markers for early detection of CHB-infected patients who are at risk of progression to cirrhosis and/or HCC. | 28562750 |
| Stomach Carcinoma | Epigenetic Alterations | Long noncoding RNA UCA1 induced by SP1 promotes cell proliferation via recruiting EZH2 and activating AKT pathway in gastric cancer. | 28569779 |
| Malignant Neoplasms, Initiation | Epigenetic Alterations | Long noncoding RNA UCA1 has emerged as a novel regulator in cancer initiation and progression of various cancers. | 28569779 |
| Diabetic Retinopathy, Vitreous humor | Epigenetic Alterations | MicroRNA-200b Expression in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy. | 28571008 |
| PDR gene | Epigenetic Alterations | miRNA-200b expression was about 5-fold increased in the vitreous samples from eyes with PDR compared with the controls (p <= 0.001). | 28571008 |
| PDR gene, stress-induced mitochondrial fusion | Epigenetic Alterations | Vitreous VEGF expression was also significantly higher in the PDR group than in the IMH group (p <= 0.001), but no significant correlation was found between miRNA-200b and VEGF. | 28571008 |
| PDR gene | Epigenetic Alterations | Both miRNA-200b and VEGF are increased in the vitreous of patients with PDR but in a noncorrelated pattern. | 28571008 |
| PDR gene | Epigenetic Alterations | miRNA-200b may be involved in the pathogenesis of PDR but through VEGF-independent mechanisms. | 28571008 |
| Prostate Cancer Pathway | Epigenetic Alterations | Plasma microRNA signature is associated with risk stratification in prostate cancer patients. | 28571116 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | We identified 27 up- and 2 downregulated plasma miRNAs in PCa patients compared with healthy men. | 28571116 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | These miRNAs may be promising therapeutic targets for high-risk PCa stratification. | 28571116 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Genome-wide DNA methylation profiling integrated with gene expression profiling identifies PAX9 as a novel prognostic marker in chronic lymphocytic leukemia. | 28572861 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | The integration of DNA methylation profile (n = 14) with the gene expression profile (n = 21) revealed 142 genes as hypermethylated-downregulated and; 62 genes as hypomethylated-upregulated in early stage CLL patients compared to CD19+ B-cells from healthy individuals. | 28572861 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | The DNA methylation changes associated with mRNA expression of CRY1 and PAX9 genes allow risk stratification of early stage CLL patients. | 28572861 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | This comprehensive analysis supports the concept that the epigenetic changes along with the altered expression of genes have the potential to predict clinical outcome in early stage CLL patients. | 28572861 |
| Communicable Diseases, Malignant neoplasm of mouth | Epigenetic Alterations | Although epigenetic alterations, such as aberrant DNA methylation, are known to contribute to the pathogenesis of oral cancer, the relationship of such alterations with EBV infection is little known. | 28573642 |
| Communicable Diseases | Epigenetic Alterations | These results indicate that epigenetic changes frequently occur in OSCCs and may partly be induced by EBV infection, therefore, EBV may involve in development and progression of the OSCCs. | 28573642 |
| Transitional cell carcinoma of bladder | Epigenetic Alterations | Increased expression of long non-coding RNA CCEPR is associated with poor prognosis and promotes tumorigenesis in urothelial bladder carcinoma. | 28574830 |
| Neoplasms | Epigenetic Alterations | Recent emerging evidences have showed that long non-coding RNAs play important regulatory roles in diverse biological processes of tumor development and progression. | 28574830 |
| Primary malignant neoplasm | Epigenetic Alterations | Genetic variations in miRNA binding domains influence the susceptibility to several diseases such as cancer. | 28578017 |
| melanoma, Neoplasms | Epigenetic Alterations | We identified and validated biomarkers for, and pathways involved in, melanoma development (e.g., HOXA9 DNA methylation) and tumor progression (e.g., TBC1D16 DNA methylation). | 28578692 |
| Neoplasms | Epigenetic Alterations | In addition, we determined a prognostic signature with potential clinical applicability and validated PON3 DNA methylation and OVOL1 protein expression as biomarkers with prognostic information independent of tumor thickness and ulceration. | 28578692 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Genome-scale identification of microRNA-related SNPs associated with risk of head and neck squamous cell carcinoma. | 28582492 |
| Primary malignant neoplasm | Epigenetic Alterations | Polymorphisms in microRNAs and their target sites can disrupt microRNA-dependent gene regulation, and have been associated with cancer susceptibility. | 28582492 |
| Squamous cell carcinoma of the head and neck, Primary malignant neoplasm | Epigenetic Alterations | These results suggest microRNA-related genetic variation may contribute to the genetic susceptibility of HNSCC, and that more powerful evaluation of this class of genetic variation and their relationship with cancer risk is warranted. | 28582492 |
| Dysplasia | Epigenetic Alterations | Also, we found that gastric epithelium cells lose the TMEPAI expression concurrently with severe dysplasia progression, which probably caused by a mechanism involving specific microRNA. | 28584893 |
| Neoplasms | Epigenetic Alterations | In conclusion, these data provided evidence that epigenetic regulation of PTPRO impairs its tumor suppressor role in LSCC, and restoration of PTPRO may be a potential therapeutic strategy. | 28586036 |
| Cubital Tunnel Syndrome | Epigenetic Alterations | Differential expression of miRNAs in Osbornes ligament of cubital tunnel syndrome. | 28586055 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-148a suppresses epithelial-mesenchymal transition and invasion of pancreatic cancer cells by targeting Wnt10b and inhibiting the Wnt/b-catenin signaling pathway. | 28586066 |
| Humor | Epigenetic Alterations | MicroRNAs (miRNAs) are small, endogenous noncoding RNAs that have been detected in human aqueous humor (AH). | 28586912 |
| Neoplasms | Epigenetic Alterations | MicroRNA-16-5p Inhibits Osteoclastogenesis in Giant Cell Tumor of Bone. | 28589137 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Identification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer. | 28589857 |
| Primary malignant neoplasm | Epigenetic Alterations | Through transcriptional silencing of critical cancer-related genes, epigenetic change such as DNA methylation plays a crucial role in cancer. | 28589857 |
| Primary malignant neoplasm | Epigenetic Alterations | However, a mechanistic role of synergistic interactions between DNA methylation and miRNA as epigenetic regulators on transcriptomic changes and its association with clinical outcomes such as survival have remained largely unexplored in cancer. | 28589857 |
| METRNL gene | Epigenetic Alterations | Then, 11 significant epigenetic interactions between miRNA and methylation, which target E2F3, CCND1, UTP6, CDADC1, SLC35E3, METRNL, TPCN2, NACC2, VGLL4, and PTEN, were found to be associated with survival. | 28589857 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | To this end, exploration of TCGA bladder cancer data identified epigenetic interactions that are associated with survival as potential prognostic markers in bladder cancer. | 28589857 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Given the importance and prevalence of these interactions of epigenetic events in bladder cancer it is timely to understand further how different epigenetic components interact and influence each other. | 28589857 |
| Neoplasms | Epigenetic Alterations | In two tumors with 12q rearrangements, RPSAP52 on 12q14.3 was fused with non-coding RNA (accession number XR_944195) from 14q32.2 or ZFP36L1 from14q24.1. | 28591699 |
| Dysplasia, Fibrosis Assessment | Epigenetic Alterations | Conclusions: De novo JAK2mut AML is rare and frequently found in patients with dysplasia, BM fibrosis, and abnormal karyotype with intermediate- or high-risk features; gene mutations in DNA methylation and epigenetic-modifying pathways; and absence of gene mutations in activating signaling pathways. | 28596259 |
| Stomach Carcinoma | Epigenetic Alterations | Polymorphisms of microRNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer. | 28596683 |
| MEN1 wt Allele, Deficiency | Epigenetic Alterations | MEN1 mutations and potentially MEN1-targeting miRNAs are responsible for menin deficiency in sporadic and MEN1 syndrome-associated primary hyperparathyroidism. | 28597079 |
| MEN1 wt Allele | Epigenetic Alterations | In silico target prediction was used to identify miRNAs potentially targeting MEN1. | 28597079 |
| Malignant Neoplasms | Epigenetic Alterations | A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-b (lncRNA-ATB) has been recently shown to promote the invasion-metastasis cascade in various types of cancers via upregulation of some targets including ZEB1. | 28598827 |
| Malignant Neoplasms | Epigenetic Alterations | Impaired miRNAs processing pathway is one interesting scenario for global downregulation of the miRNAome in various types of malignancy. | 28598829 |
| Multiple Myeloma | Epigenetic Alterations | Two serum microRNAs, miRNA-720 and miRNA-1246, were found to have potential as diagnostic biomarkers in myeloma. | 28601493 |
| Initiation | Epigenetic Alterations | Involvement of microRNAs has been demonstrated in cancer initiation and progression. | 28602785 |
| Malignant Neoplasms, Nodular thyroid disease | Epigenetic Alterations | It has recently been demonstrated that the combination of miRNA-190 and -95 (expressed as probability of malignant risk: pmiRNA) in the serum of Caucasian patients with thyroid nodular disease allows the identification of nodules at high risk of malignancy with great accuracy. | 28605303 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway. | 28606154 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Increasing evidences demonstrate that miRNAs contribute to development and progression of hepatocellular carcinoma (HCC). | 28606154 |
| Primary malignant neoplasm | Epigenetic Alterations | Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non-Small Cell Lung Cancer Using Next-Generation Sequencing. | 28606918 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Exosomal miRNA profiling of 46 stage I NSCLC patients and 42 healthy individuals was performed using miRNA-seq to identify and validate adenocarcinoma- and SCC-specific miRNAs. | 28606918 |
| Adenocarcinoma, SERPINB3 wt Allele | Epigenetic Alterations | The diagnostic accuracy of select miRNAs was tested further with an additional 60 individuals.Results: There were 11 and 6 miRNAs expressed at remarkably higher levels, 13 and 8 miRNAs expressed at lower levels in adenocarcinoma and SCC patients, respectively, compared with healthy volunteers. | 28606918 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These miRNAs may be promising and effective candidates in the development of highly sensitive, noninvasive biomarkers for early NSCLC diagnosis. | 28606918 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Association between genetic variants in the promoter region of a novel antisense long noncoding RNA RP11-392P7.6 and colorectal cancer risk. | 28612367 |
| Primary malignant neoplasm | Epigenetic Alterations | Ectopic expression of mature miRNA demonstrated that all members of the miR-199 family inhibited cancer cell migration and invasion by HNSCC cell lines (SAS and HSC3). | 28612520 |
| Primary malignant neoplasm | Epigenetic Alterations | These findings suggested that both passenger strands and guide strands of miRNA are involved in cancer pathogenesis. | 28612520 |
| Carcinoma of lung | Epigenetic Alterations | Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression. | 28615056 |
| Malignant Head and Neck Neoplasm | Epigenetic Alterations | Epigenetic silencing of SALL3 is an independent predictor of poor survival in head and neck cancer. | 28616099 |
| Tongue Carcinoma | Epigenetic Alterations | For qPCR of miR-183 and miR-21 expression, total RNA isolated from 60 fresh-frozen tissue of tongue carcinomas was converted into cDNA by TaqMan MicroRNA Reverse Transcription Kit and quantified by TaqMan MicroRNAs Expression Assays. | 28616749 |
| cervical cancer | Epigenetic Alterations | Expression of microRNA-142-3p in cervical cancer and its correlation with prognosis. | 28617557 |
| Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Increasing evidence suggests that circulating miRNAs in serum and urine may be potential non-invasive biomarkers for prostate cancer (PCa). | 28617988 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | In serum EVs, four miRNAs were significantly higher in patients with PCa than with BPH. | 28617988 |
| Cardiovascular Diseases | Epigenetic Alterations | Many circulating microRNAs (miRs) have been shown to have potential biomarker effects in cardiovascular disease. | 28618405 |
| Cardiovascular Diseases | Epigenetic Alterations | MicroRNA are noncoding RNA that have a significant role in both inflammatory and cardiovascular diseases. | 28618412 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Failed Downregulation of Circulating MicroRNA-155 in the Early Phase after ST Elevation Myocardial Infarction Is Associated with Adverse Left Ventricular Remodeling. | 28618412 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Prognostic Significance of microRNA-7 and its Roles in the Regulation of Cisplatin Resistance in Lung Adenocarcinoma. | 28618418 |
| Malignant Neoplasms, Adenocarcinoma of lung (disorder), Neoplasms | Epigenetic Alterations | Previously, microRNA (miR)-7 has been reported to function as a tumor suppressor in human cancers, but the correlations of miR-7 expression with prognosis and cisplatin (CDDP) resistance in lung adenocarcinoma (LA) are unclear. | 28618418 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA MSTO2P promotes the proliferation and colony formation in gastric cancer by indirectly regulating miR-335 expression. | 28618927 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA misato family member 2, pseudogene influenced biologic functions in gastric cancer cells via indirectly regulating the activation of miR-335. | 28618927 |
| Stomach Carcinoma | Epigenetic Alterations | Therefore, long non-coding RNAs might function as key regulatory hubs in gastric cancer progression. | 28618927 |
| Colorectal Cancer Pathway | Epigenetic Alterations | High expression of long non-coding RNA ZEB1-AS1 promotes colorectal cancer cell proliferation partially by suppressing p15 expression. | 28618933 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer. | 28618943 |
| Stomach Carcinoma | Epigenetic Alterations | Taken together, our findings suggest that the long non-coding RNA differentiation antagonizing non-protein coding RNA promotes the proliferation of gastric cancer and is a potential prognostic biomarker and therapeutic target in gastric cancer. | 28618943 |
| Stomach Carcinoma | Epigenetic Alterations | Experiments revealed that silencing differentiation antagonizing non-protein coding RNA significantly inhibited gastric cancer cell proliferation in vitro and in vivo. | 28618943 |
| Stomach Carcinoma | Epigenetic Alterations | Overexpression of differentiation antagonizing non-protein coding RNA notably increases gastric cancer cell proliferation. | 28618943 |
| Stomach Carcinoma | Epigenetic Alterations | Recent evidence indicates that long non-coding RNAs play crucial roles in development and progression of gastric cancer. | 28618943 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Dysregulation in microRNA expression is a common feature in colorectal cancer. | 28618945 |
| Esophageal carcinoma | Epigenetic Alterations | Decreased expression of MGMT in correlation with aberrant DNA methylation in esophageal cancer patients from North India. | 28621225 |
| Liver carcinoma | Epigenetic Alterations | Long non-coding RNA CASC2 regulates cell biological behaviour through the MAPK signalling pathway in hepatocellular carcinoma. | 28621238 |
| Malignant neoplasm of endometrium, Glioma, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | The long non-coding RNA CASC2 (cancer susceptibility candidate 2) has been characterised as a tumour suppressor in endometrial cancer and gliomas. | 28621238 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs have previously been demonstrated to play important roles in regulating human diseases, especially cancer. | 28621238 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | A microRNA signature associated with pathological complete response to novel neoadjuvant therapy regimen in triple-negative breast cancer. | 28621239 |
| Breast Carcinoma | Epigenetic Alterations | In summary, we identified a novel microRNA expression signature associated with pathological complete response in breast cancer. | 28621239 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNAs are known biomarkers of breast cancer progression; nevertheless, their potential to identify patients with pathological complete response remains poorly understood. | 28621239 |
| Verrucous carcinoma | Epigenetic Alterations | Research on miRNA-195 and target gene CDK6 in oral verrucous carcinoma. | 28621315 |
| SERPINB3 wt Allele | Epigenetic Alterations | The expression of miRNA from OVC and OSCC including their matched normal oral mucosa tissues was profiled through the Affymetrix GeneChip miRNA Arrays. | 28621315 |
| SERPINB3 wt Allele | Epigenetic Alterations | In addition, miRNA-195 was significantly decreased in both OVC and OSCC compared to normal oral mucosa. | 28621315 |
| SERPINB3 wt Allele | Epigenetic Alterations | CDK6 was increased in OVC and OSCC, which was opposite to the expression of miRNA-195. | 28621315 |
| SERPINB3 wt Allele | Epigenetic Alterations | Moreover, 44 miRNAs were differentially expressed between OSCC and OVC. | 28621315 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Plasma microRNA-19a as a potential biomarker for esophageal squamous cell carcinoma diagnosis and prognosis. | 28621611 |
| Primary malignant neoplasm | Epigenetic Alterations | The antisense noncoding RNA in the INK4 locus codes for a long noncoding RNA whose participation in cancer has been elucidated. | 28621612 |
| Prostate Cancer Pathway | Epigenetic Alterations | A Panel of MicroRNAs as Diagnostic Biomarkers for the Identification of Prostate Cancer. | 28621736 |
| Rheumatic disease of heart valve | Epigenetic Alterations | DNA methylation dysregulations in rheumatic heart valve disease. | 28623907 |
| Rheumatic disease of heart valve | Epigenetic Alterations | The epigenetic changes underlying the development of rheumatic heart valve disease (RHVD) remain incompletely understood. | 28623907 |
| Steatohepatitis | Epigenetic Alterations | DNA methylation at SLC7A11 was associated with reduced risk of hepatic steatosis in participants (odds ratio, 0.69; 95% CI= 0.55-0.93; P value: 2.7 x 10-3). | 28624579 |
| Fatty degeneration | Epigenetic Alterations | Our results provide new insights into epigenetic mechanisms associated with markers of liver function and hepatic steatosis, laying the groundwork for future diagnostic and therapeutic applications. | 28624579 |
| Metastasis, Neoplasms | Epigenetic Alterations | We considered genome-wide mRNA and miRNA expression and mutation status of 20 genes assayed in 150 fresh-frozen tumours with known metastasis status. | 28624625 |
| Gallbladder Carcinoma | Epigenetic Alterations | Long non-coding RNA UCA1 promotes gallbladder cancer progression by epigenetically repressing p21 and E-cadherin expression. | 28624787 |
| Medical Device Material Rupture | Epigenetic Alterations | Out of 24 miRNAs selected for replication, 6 miRNAs remained significantly associated with plaque rupture. | 28624816 |
| Medical Device Material Rupture | Epigenetic Alterations | In the validation phase, combinations of miR-483-5p and miR-451a showed the highest area under the receiver-operating-characteristic curve (AUC) (0.982; CI: 0.907-0.999) in patients with plaque rupture for 0.5 h; combinations of miR-483-5p and miR-155-5p showed the highest AUC (0.898; CI: 0.790-0.962) after plaque rupture for 1 h. In conclusion, using a profiling-replication-validation model, we identified 3 miRNAs including miR-155-5p, miR-483-5p and miR-451a, which may be biomarkers for the early identification of plaque rupture. | 28624816 |
| ABCB1 wt Allele, Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | We hypothesize that selected genetic and/or epigenetic changes associated with advanced tumours may help identifying early non-small cell lung cancers (NSCLCs) that recur after resection. | 28625654 |
| Hypomethylation, Carcinogenesis, Primary malignant neoplasm | Epigenetic Alterations | Among epigenetic changes, long interspersed nuclear element-1 (LINE-1) hypomethylation is seen early during carcinogenesis and may act in concert with genetic alterations to cancer progression. | 28625654 |
| Carcinogenesis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Genetic and epigenetic events occurring in early carcinogenesis may help identifying stage I NSCLC patients who deserve adjuvant therapy. | 28625654 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Alterations of miRNAs in rheumatoid arthritis (RA) have been reported, however, the components of the RNAi machinery in RA remain to be fully elucidated. | 28627619 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | microRNA-205 acts as a tumor suppressor and directly targets YAP1 in glioma. | 28627687 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | It is well-established that microRNAs (miRs) are associated with the regulation of glioma initiation and progression, and may represent a novel effective therapeutic strategy for the treatment of glioma. | 28627687 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-508-5p suppresses metastasis in human gastric cancer by targeting S-phase kinase-associated protein 2. | 28627698 |
| Prostate Cancer Pathway | Epigenetic Alterations | Heterogeneity of miRNA expression in localized prostate cancer with clinicopathological correlations. | 28628624 |
| Neoplasms | Epigenetic Alterations | However, tumor heterogeneity may influence miRNA expression. | 28628624 |
| Prostatic Hyperplasia, CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Four miRNAs (miRNA-21, miRNA-34a, miRNA-125, and miRNA-126) were significantly upregulated in PCa compared to benign prostatic hyperplasia (BPH), and except for miRNA-21 these miRNAs documented a positive correlation between the expression level in PCa cores and their matched BPH cores, (r > 0.72). | 28628624 |
| Neoplasms | Epigenetic Alterations | The results, however, document intra-tumoral heterogeneity in the expression of various miRNAs calling for caution when using these tumor tissue biomarkers in prognostic and predictive settings. | 28628624 |
| Neoplasms | Epigenetic Alterations | Together, these data suggest that tumor suppressor microRNAs contribute to the regulation of PD-L1 expression in MPM. | 28629895 |
| Hypoxia | Epigenetic Alterations | Long noncoding RNA H19 is repressed after birth, but can be induced by hypoxia. | 28630232 |
| Prostate Cancer Pathway | Epigenetic Alterations | Inhibition of microRNA-500 has anti-cancer effect through its conditional downstream target of TFPI in human prostate cancer. | 28631332 |
| Uterine Cervical Neoplasm | Epigenetic Alterations | Genetic and epigenetic alterations affecting PARK-2 expression in cervical neoplasm among North Indian patients. | 28631565 |
| Primary malignant neoplasm | Epigenetic Alterations | Abnormal expression of microRNAs has been reported to regulate gene expression and cancer cell growth, invasion, and migration. | 28631567 |
| Nasopharyngeal carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA 183 (miR-183) was identified to be downregulated in nasopharyngeal carcinoma spheroids and served as a tumor suppressor in nasopharyngeal carcinoma. | 28631568 |
| Hidradenitis Suppurativa | Epigenetic Alterations | The microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: a significant dysregulation within active inflammatory lesions. | 28634830 |
| Hidradenitis Suppurativa | Epigenetic Alterations | Recently, we could show that the expression levels of the key regulators of the microRNA (miRNA) maturation and transport were dysregulated in inflamed hidradenitis suppurativa (HS) tissue (Heyam et al. | 28634830 |
| Breast Carcinoma, Neoplasm Metastasis | Epigenetic Alterations | MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. | 28637482 |
| Primary malignant neoplasm, Neoplasm Metastasis | Epigenetic Alterations | Members of the microRNA (miR)-200 family, which are involved in tumor metastasis, have potential as cancer biomarkers, but their regulatory mechanisms remain elusive. | 28637482 |
| Hepatitis C Virus-Related Hepatocellular Carcinoma | Epigenetic Alterations | Validation of a serum microRNA panel as biomarkers for early diagnosis of hepatocellular carcinoma post-hepatitis C infection in Egyptian patients. | 28638226 |
| Hollings Cancer Center | Epigenetic Alterations | Each miRNA can show HCC progression. | 28638226 |
| Hollings Cancer Center | Epigenetic Alterations | Expression of the selected miRNAs in serum was significantly lower in HCC patients than in the healthy controls, except for miR-1269 and miR-494. | 28638226 |
| Carcinoma, Transitional Cell, Neoplasms | Epigenetic Alterations | Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma. | 28638274 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. | 28638274 |
| Liver carcinoma | Epigenetic Alterations | miRNA Signature of Hepatocellular Carcinoma Vascularization: How the Controls Can Influence the Signature. | 28639131 |
| Hollings Cancer Center | Epigenetic Alterations | To assess the differences existing in the quantitative miRNA gene expression in HCC on tissue according to two different liver controls. | 28639131 |
| Hollings Cancer Center | Epigenetic Alterations | Still we observed the deregulation of some common miRNAs as promising in HCC cancerogenesis and progression. | 28639131 |
| Kidney Neoplasm | Epigenetic Alterations | While the miRNA profiles of renal tumors have been extensively explored, knowledge of their circulating counterparts is limited. | 28639257 |
| Neoplasms | Epigenetic Alterations | Advanced tumors, characterized as stage III and IV, were associated with specific miRNA signatures that significantly differ from both controls and earlier stage ccRCC cases. | 28639257 |
| Conventional (Clear Cell) Renal Cell Carcinoma, Late stage | Epigenetic Alterations | Large-scale genome-wide screening of circulating microRNAs in clear cell renal cell carcinoma reveals specific signatures in late-stage disease. | 28639257 |
| Neoplasms | Epigenetic Alterations | Circulating miRNAs have shown great promises as noninvasive diagnostic and predictive biomarkers in several solid tumors. | 28639257 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | In summary, our results suggest that circulating miRNAs may provide insights into renal cell carcinoma progression. | 28639257 |
| Sample Size Calculation | Epigenetic Alterations | Expression of circulating microRNA-5196 was correlated with SSc parameters. | 28639412 |
| fibrogenesis, Sample Size Calculation | Epigenetic Alterations | Exogenous delivery of microRNA-5196 reduced Fra2 and TIMP-1 expression suggesting that it may be used as a potential modulator of fibrogenesis in SSc. | 28639412 |
| Sample Size Calculation | Epigenetic Alterations | These results suggest that microRNA-5196 can be used as a potential biomarker characterising SSc. | 28639412 |
| Stomach Carcinoma | Epigenetic Alterations | Evaluation of serum microRNA biomarkers for gastric cancer based on blood and tissue pools profiling: the importance of miR-21 and miR-331. | 28641313 |
| Stomach Carcinoma | Epigenetic Alterations | High stability and disease-specific disarrangements suggest that microRNA molecules (miRNAs) present in body fluids are ideally suited for diagnostic applications, including gastric cancer (GC). | 28641313 |
| Primary Neoplasm | Epigenetic Alterations | The results indicate that the majority of potential serum miRNA biomarkers may originate from tissues other than the primary tumour. | 28641313 |
| cervical cancer | Epigenetic Alterations | MicroRNA-337 inhibits cell proliferation and invasion of cervical cancer through directly targeting specificity protein 1. | 28641487 |
| cervical cancer | Epigenetic Alterations | We found that microRNA-337 expression was significantly downregulated in cervical cancer tissues and cell lines. | 28641487 |
| cervical cancer | Epigenetic Alterations | The ectopic expression of microRNA-337 suppressed cell proliferation and invasion of cervical cancer in vitro. | 28641487 |
| cervical cancer | Epigenetic Alterations | Furthermore, specificity protein 1 was identified as a direct target of microRNA-337 in cervical cancer. | 28641487 |
| cervical cancer | Epigenetic Alterations | The expression of specificity protein 1 increased in cervical cancer tissues and negatively correlated with microRNA-337 expression level. | 28641487 |
| cervical cancer | Epigenetic Alterations | Moreover, rescue experiments revealed that upregulation of specificity protein 1 could rescue the effects of microRNA-337 on cervical cancer cells. | 28641487 |
| cervical cancer | Epigenetic Alterations | Taken together, these findings collectively demonstrate that microRNA-337 exerts its tumor-suppressing roles in cervical cancer by directly targeting specificity protein 1, thereby indicating a potential novel potential therapeutic target for patients with cervical cancer. | 28641487 |
| Malignant Neoplasms, cervical cancer, Neoplasms | Epigenetic Alterations | Accumulated studies have demonstrated that the aberrant expression of microRNAs plays important roles in tumorigenesis and tumor development and potentially serves as therapeutic targets in various cancers including cervical cancer. | 28641487 |
| cervical cancer | Epigenetic Alterations | Therefore, the identification of specific microRNAs contributed to cervical cancer formation and progression would provide critical clues for the treatments for patients with this disease. | 28641487 |
| Degenerative polyarthritis | Epigenetic Alterations | Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats. | 28647469 |
| Degenerative polyarthritis | Epigenetic Alterations | An OA model was induced surgically in rats, and subsequently treated with one single intra-articular injection of miRNA-140 agomir. | 28647469 |
| Degenerative polyarthritis | Epigenetic Alterations | Intra-articular injection of miRNA-140 can alleviate OA progression by modulating ECM homeostasis in rats, and may have potential as a new therapy for OA. | 28647469 |
| Degenerative polyarthritis | Epigenetic Alterations | miRNA-146a, miRNA-155 and JNK expression levels in peripheral blood mononuclear cells according to grade of knee osteoarthritis. | 28647559 |
| Degenerative polyarthritis | Epigenetic Alterations | However, miRNA-146a and miRNA-155 expressions increased in the progressive stages (grade 3 and grade 4) in OA patients. | 28647559 |
| Degenerative polyarthritis | Epigenetic Alterations | Our data suggests that correlation of miRNAs regulating and signal pathways can play an important role in OA pathogenesis and disease progression. | 28647559 |
| Osteoporotic Fractures | Epigenetic Alterations | Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women. | 28650214 |
| Osteoporosis | Epigenetic Alterations | DNA methylation affects expression of associated genes and may contribute to the missing genetic effects from genome-wide association studies of osteoporosis. | 28650214 |
| Osteoporosis, Postmenopausal | Epigenetic Alterations | To improve insight into the mechanisms of postmenopausal osteoporosis, we combined transcript profiling with DNA methylation analyses in bone. | 28650214 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma. | 28653805 |
| Multiple Chronic Conditions, Malignant Neoplasms, Metastasis | Epigenetic Alterations | Aberrant microRNA expression is involved in the regulation of various cellular processes, such as proliferation and metastasis in multiple diseases including cancers. | 28653805 |
| Malignant Neoplasms, Adenocarcinoma of lung (disorder), Neoplasms | Epigenetic Alterations | MicroRNA-30e-5p (miR-30e) was previously reported as an oncogenic or tumour suppressing miRNA in some malignancies, but its function in lung adenocarcinoma (LAC) remains largely undefined. | 28653805 |
| Endometrial Carcinoma, Neoplasms | Epigenetic Alterations | Long non-coding RNA tumor suppressor candidate 7 advances chemotherapy sensitivity of endometrial carcinoma through targeted silencing of miR-23b. | 28653877 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | TUSC7 (tumor suppressor candidate 7) is an antisense long non-coding RNA and is downregulated and acts as a potential tumor suppressor in several malignant tumors. | 28653877 |
| Endometrial Carcinoma, Neoplasms | Epigenetic Alterations | In summary, long non-coding RNA TUSC7 was underexpressed in endometrial carcinoma, especially in endometrial carcinoma chemotherapy-resistant tissues and cell lines and acted as a potential tumor suppressor gene to inhibit cell growth as well as advance the chemotherapy sensitivity through targeted silencing of miR-23b, which might provide a new therapeutic target to endometrial carcinoma. | 28653877 |
| Mitochondria, Nerve Degeneration, "Alzheimers Disease", Loading Technique | Epigenetic Alterations | Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might be involved in late-onset Alzheimers disease (LOAD), but evidence in humans is limited. | 28655136 |
| Malignant neoplasm of thyroid | Epigenetic Alterations | Effects of long non-coding RNA H19 and microRNA let7a expression on thyroid cancer prognosis. | 28655518 |
| GDC Tumor Code Terminology, Neoplasms | Epigenetic Alterations | In TC patients with tumor diameters>=1.0cm, lncRNA H19 mRNA expression was elevated, but miRNA let7a mRNA expression was reduced. | 28655518 |
| GDC Tumor Code Terminology | Epigenetic Alterations | TC patients with a lower 5-year survival rate showed upregulated levels of lncRNA H19 expression and, downregulated levels of miRNA let7a expression. | 28655518 |
| Tetranitromethane, Metastasis, Neoplasms | Epigenetic Alterations | LncRNA H19 and miRNA let7a expression, tumor diameter, TNM stage and lymph node metastasis were independent prognostic factors of TC. | 28655518 |
| Discordance | Epigenetic Alterations | The discordance between the high prevalence of mutations in these 2 genes and their limited biological impact raise the question of the potential role of dysregulated epigenetic modifiers in normal aging hematopoiesis, which may include support to failing hematopoiesis. | 28655780 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are a group of non-protein-coding, short single-stranded RNAs, which are considered as promising molecular markers and therapeutic targets in several cancers. | 28656198 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-661 promotes non-small cell lung cancer progression by directly targeting RUNX3. | 28656235 |
| Malignant Neoplasms, Carcinogenesis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Increasing evidence indicates that abnormal microRNA (miRNA) expression contributes to the carcinogenesis and progression of multiple human cancers, including non-small cell lung cancer (NSCLC). | 28656235 |
| Breast Cancer Cell | Epigenetic Alterations | miRNA-661 (miR-661) has previously been demonstrated to be important in the development of various human cancer types. | 28656235 |
| Malignant Neoplasms | Epigenetic Alterations | Therefore, miRNAs exhibit the potential to act as biomarkers for the diagnosis, treatment and prognosis of human malignancies. | 28656235 |
| Papillary thyroid carcinoma | Epigenetic Alterations | MicroRNA-150 targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in papillary thyroid carcinoma. | 28656254 |
| Malignant Neoplasms, Papillary thyroid carcinoma, Malignant neoplasm of thyroid, F9 gene | Epigenetic Alterations | Dysregulation of microRNAs is well-known to contribute to the development of various cancers, including papillary thyroid carcinoma (PTC), which accounts for 80-90% of all thyroid cancer cases. | 28656254 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma. | 28656255 |
| Malignant Neoplasms | Epigenetic Alterations | Accumulating evidence demonstrates that dysregulated microRNAs (miRNAs) play a critical role in tumorigenesis and progression of various cancers. | 28656255 |
| Neoplasms | Epigenetic Alterations | In recent years, accumulating evidence has demonstrated that microRNAs (miRs, miRNAs) may serve an important role in the occurrence and development of tumors. | 28656260 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs play roles in almost all aspects of cancer biology, and can be secreted into the circulation and serve as molecular biomarkers for the early diagnosis of cancer. | 28656287 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | Long non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186-5p to promote the tumorigenesis and metastasis of hepatocellular carcinoma. | 28656879 |
| Malignant Neoplasms | Epigenetic Alterations | Long non-coding RNA plasmacytoma variant translocation 1 has been reported to be dysregulated and plays a crucial role in various cancers. | 28656879 |
| Ulcerative Colitis, Crohn Disease | Epigenetic Alterations | These 45 variants are significantly enriched for protein-coding changes (n = 13), direct disruption of transcription-factor binding sites (n = 3), and tissue-specific epigenetic marks (n = 10), with the last category showing enrichment in specific immune cells among associations stronger in Crohns disease and in gut mucosa among associations stronger in ulcerative colitis. | 28658209 |
| Conventional (Clear Cell) Renal Cell Carcinoma, Metastasis | Epigenetic Alterations | Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling. | 28659173 |
| Malignant Neoplasms | Epigenetic Alterations | Recent evidences showed that long noncoding RNAs (lncRNAs) are frequently dysregulated and play important roles in various cancers. | 28659173 |
| Hurthle Cell Tumor | Epigenetic Alterations | These results indicate that the noncoding RNAs MALAT1 and miR-885 show increased expression in neoplastic follicular and Hurthle cell thyroid neoplasms compared to normal thyroid tissues. | 28660408 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | microRNA-145-3p inhibits non-small cell lung cancer cell migration and invasion by targeting PDK1 via the mTOR signaling pathway. | 28661070 |
| Neoplasm Metastasis | Epigenetic Alterations | We found that miR-29a overexpression increased DNA methylation of suppressor of cytokine signaling 1 (SOCS1) promoter was associated with HCC metastasis in vitro and in vivo. | 28661477 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Ten eleven translocation (TET) enzymes convert 5-methylcytosine (5-mC) to 5-hydroxy-methylcytosine (5-hmC) and have crucial roles in biological and pathological processes by mediating DNA demethylation, however, the functional role of this epigenetic mark and the related enzymes in hepatocellular carcinoma (HCC) progression remains unknown. | 28661477 |
| Hollings Cancer Center, Neoplasm Metastasis | Epigenetic Alterations | In conclusion, our findings demonstrate that 5-hmC loss is an epigenetic hallmark of HCC, and miR-29a is an important epigenetic modifier, promoting HCC metastasis through TET-SOCS1-MMP9 axis silencing. | 28661477 |
| Primary malignant neoplasm | Epigenetic Alterations | The results offer a new strategy for epigenetic cancer therapy. | 28661477 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | MicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TET-SOCS1-MMP9 signaling axis. | 28661477 |
| Kidney Neoplasm | Epigenetic Alterations | Promoter methylation has emerged as a promising class of epigenetic biomarkers for diagnosis and prognosis of renal cell tumors (RCTs). | 28662726 |
| Acute myocardial infarction | Epigenetic Alterations | MicroRNAs (miRs) have shown to exert fibrotic and anti-fibrotic effects in preclinical models of acute myocardial infarction (AMI). | 28663047 |
| Neoplasms | Epigenetic Alterations | Tumors with loss of MLH1/PMS2 were subsequently tested for BRAF mutation or MLH1 promoter methylation to identify tumors with likely epigenetic inactivation of MLH1. | 28664346 |
| Lupus Erythematosus, Systemic, Lupus Erythematosus | Epigenetic Alterations | Finally, miRNA expression in T lymphocytes and MVs of healthy individuals was compared with those of systemic lupus erythematosus (SLE) patients. | 28665018 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Accumulating evidence demonstrates that aberrant miRNAs contribute to hepatocellular carcinoma (HCC) development and progression. | 28666208 |
| Hollings Cancer Center | Epigenetic Alterations | However, the roles of various miRNAs in HCC remain to be determined. | 28666208 |
| Carcinoma of lung, Metastasis | Epigenetic Alterations | Furthermore, SATB2 suppressed lung cancer cell invasion and metastasis and regulated the expression of EMT-related proteins and histone methylation by G9a. | 28667416 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Transcription factor-microRNA associations and their impact on colorectal cancer survival. | 28667784 |
| Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) and Transcription Factors (TFs) both influence messenger RNA (mRNA) expression, disrupting biological pathways involved in carcinogenesis and prognosis. | 28667784 |
| Primary malignant neoplasm | Epigenetic Alterations | As many miRNAs target multiple mRNAs, thus influencing a multitude of biological pathways, deciphering which miRNAs are important for cancer development and survival is difficult. | 28667784 |
| Primary malignant neoplasm | Epigenetic Alterations | Five factors, comprising 21 miRNAs, altered survival in rectal cancer subjects; four of these five factors improved survival and one factor reduced survival. | 28667784 |
| Malignant tumor of colon | Epigenetic Alterations | One factor comprising four miRNAs reduced survival in colon cancer subjects. | 28667784 |
| Colorectal Cancer Pathway | Epigenetic Alterations | In summary, our data suggest that expression of TFs and their related miRNAs influence survival after diagnosis with colorectal cancer. | 28667784 |
| Myeloid Leukemia, Chronic | Epigenetic Alterations | Mutations in genes associated with epigenetic regulations such as DNMT3A and ASXL1 seem to play an important role in the pathogenesis of CML progression and TKI-resistance independent of ABL1 KD mutations. | 28667884 |
| Intervertebral disc disorder | Epigenetic Alterations | Dysregulation of microRNAs (miRNAs) is involved in the development of IDD. | 28667916 |
| Fibrosis Assessment | Epigenetic Alterations | MicroRNAs are reported to play important roles in regulating fibrosis in different organs. | 28669725 |
| Malignant tumor of colon | Epigenetic Alterations | MicroRNA 375 regulates proliferation and migration of colon cancer cells by suppressing the CTGF-EGFR signaling pathway. | 28670764 |
| Clinical Coordinator, Colorectal Cancer Pathway, Malignant tumor of colon | Epigenetic Alterations | MicroRNA 375 (MIR375) is significantly down regulated in human colorectal cancer (CRC) tissues; we have previously identified MIR375 as a colon cancer associated microRNA (miRNA). | 28670764 |
| Malignant Neoplasms | Epigenetic Alterations | CCAT2 (colon cancer-associated transcript 2) gene is affiliated with long non-coding RNAs, which are often found to have important regulatory roles in cancers. | 28671055 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-133b expression associates with clinicopathological features and prognosis in glioma. | 28675056 |
| Malignant Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Recently, microRNA-133b (miR-133b) dysregulation has been shown to play a key role in several human cancers, as well as glioma. | 28675056 |
| Breast Carcinoma | Epigenetic Alterations | This study provided evidence that long non-coding RNA MALAT1 was up-regulated in breast cancer tissues and cell lines. | 28675122 |
| Neoplasm Metastasis | Epigenetic Alterations | Long non-coding RNAs recently were identified as key mediators of cancer metastasis. | 28675122 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. | 28675510 |
| Primary malignant neoplasm | Epigenetic Alterations | MiRNAs also contribute to cellular pathways leading to cancer. | 28675510 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | We use data from 217 colorectal cancer (CRC) cases to evaluate differences in TSGs and OGs expression between paired CRC and normal mucosa and evaluate how TSGs and OGs are associated with miRNAs. | 28675510 |
| Decreased platelet count | Epigenetic Alterations | MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction. | 28677771 |
| Decreased platelet count | Epigenetic Alterations | However, the regulatory role of miRNAs in the pathogenesis of thrombocytopenia in ITP remains unclear. | 28677771 |
| Metastatic hepatocellular carcinoma | Epigenetic Alterations | MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1. | 28677785 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | MicroRNAs (miRNAs) play critical roles in hepatocellular carcinoma (HCC). | 28677785 |
| Primary malignant neoplasm | Epigenetic Alterations | Single nucleotide polymorphisms (SNPs) in microRNA-binding sites located in the 3-untranslated region (UTR) of target genes can have an effect on the interaction of microRNA-mediated regulation, which results in changes in the expression levels of target genes ultimately associated with cancer risk and patient prognosis. | 28677815 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The expression of PDE3A in patients with NSCLC and its DNA methylation status were analyzed in NSCLC cohort in TCGA database. | 28678321 |
| Adenocarcinoma of lung (disorder), Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Heat map of PDE3A expression and methylation in NSCLC patient cohort in TCGA database indicated a negative association between PDE3A expression and DNA methylation in lung adenocarcinoma. | 28678321 |
| Mammary Neoplasms | Epigenetic Alterations | DNA methylation analysis for the ALKBH3 promoter region was carried out by pyrosequencing (PyroMark Q24) in 265 primary breast tumours and 30 proximal normal breast tissue samples along with 8 breast-derived cell lines. | 28679371 |
| Stomach Carcinoma | Epigenetic Alterations | BRD4 promotes gastric cancer progression through the transcriptional and epigenetic regulation of c-MYC. | 28681984 |
| Stomach Carcinoma | Epigenetic Alterations | We report here that BRD4 increases the proliferation and represses the apoptosis of gastric cancer cells through activating c-MYC via transcriptional and epigenetic regulation mechanisms. | 28681984 |
| Pulmonary Hypertension | Epigenetic Alterations | Dysregulation of microRNA-214 and PTEN contributes to the pathogenesis of hypoxic pulmonary hypertension. | 28684904 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-300 promotes apoptosis and inhibits proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/b-catenin signaling pathway by targeting CUL4B in pancreatic cancer cells. | 28685847 |
| Hypertensive disease | Epigenetic Alterations | a-Adducin gene promoter DNA methylation and the risk of essential hypertension. | 28686109 |
| Metastasis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Down-regulated microRNA-375 expression as a predictive biomarker in non-small cell lung cancer brain metastasis and its prognostic significance. | 28688608 |
| Carcinogenesis | Epigenetic Alterations | microRNAs (miRNAs) play critical roles in carcinogenesis. | 28689850 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | Genetic Versus Epigenetic BRCA1 Silencing Pathways: Clinical Effects in Primary Ovarian Cancer Patients: A Study of the Tumor Bank Ovarian Cancer Consortium. | 28691938 |
| Inflammation | Epigenetic Alterations | MicroRNAs (miRs) are small noncoding RNAs that regulate gene expression, including immune activation and inflammation. | 28692540 |
| HIV-1 Infection Pathway | Epigenetic Alterations | Unique microRNA expression in the colonic mucosa during chronic HIV-1 infection. | 28692540 |
| Primary malignant neoplasm | Epigenetic Alterations | Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age. | 28693600 |
| Breast Carcinoma | Epigenetic Alterations | We tested the relation of established breast cancer risk factors, age, body mass index, parity, and family history of disease, with DNA methylation adjusting for potential variation in cell-type proportions. | 28693600 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | DNA methylation changes with age occur at regulatory regions, and are further exacerbated in cancer, suggesting that age influences breast cancer risk in part through its contribution to epigenetic dysregulation in normal breast tissue. | 28693600 |
| Asthma Pathway, Chronic Obstructive Airway Disease, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome | Epigenetic Alterations | Expression profiling of miRNA-145 and miRNA-338 in serum and sputum of patients with COPD, asthma, and asthma-COPD overlap syndrome phenotype. | 28694694 |
| Asthma Pathway, obstructive disease | Epigenetic Alterations | The main finding of this work is that the expression of miRNA-338 is higher in the supernatant of different obstructive diseases than in peripheral blood, while miRNA-145 is higher only in the supernatant of asthma patients. | 28694694 |
| Asthma Pathway, Chronic Obstructive Airway Disease | Epigenetic Alterations | Differences in sputum miRNA expression profile were observed between patients with ACOS and asthma or COPD, which underline the potential role of miRNA as a biomarker that is able to discriminate patients with ACOS, asthma, and COPD. | 28694694 |
| Asthma Pathway, Chronic Obstructive Airway Disease | Epigenetic Alterations | The expression of both selected miRNAs is higher in the supernatant of asthma and COPD patients than in controls. | 28694694 |
| Primary malignant neoplasm | Epigenetic Alterations | Urinary microRNAs (miRNAs) are emerging as a clinically useful tool for early and non-invasive detection of various types of cancer. | 28694731 |
| Refractory Cytopenia of Childhood | Epigenetic Alterations | Concentrations of all let-7 miRNAs (let-7a, let-7b, let-7c, let-7d, let-7e and let-7g) were significantly higher in urine samples obtained from RCC patients compared to healthy controls (P < 0.001; P < 0.001; P = 0.005; P = 0.006; P = 0.015 and P = 0.002, respectively). | 28694731 |
| Primary malignant neoplasm, Liver carcinoma | Epigenetic Alterations | MicroRNAs could mediate the targeted coding gene and the targeted non-coding RNA to form endogenous competition, which have an important regulatory role in tumorigenesis of many types of cancer, including hepatocellular carcinoma. | 28695771 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839. | 28695771 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer. | 28697793 |
| Chronic arthritis | Epigenetic Alterations | Our data suggest that the epigenetic configuration at gene promoters regulates cell-specific LPS-induced responses and primes SF to sustain their inflammatory response in chronic arthritis. | 28701277 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Epigenetic silencing of miR-203 in Kazakh patients with esophageal squamous cell carcinoma by MassARRAY spectrometry. | 28703658 |
| Sex Characteristics | Epigenetic Alterations | Sexual dimorphisms of mRNA and miRNA in human/murine heart disease. | 28704447 |
| Neoplasms | Epigenetic Alterations | miR-451 is a tumor suppressive microRNA with several target genes, including Macrophage migration inhibitory factor (MIF). | 28704499 |
| Colorectal Cancer Pathway | Epigenetic Alterations | E2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer. | 28704519 |
| Neoplasms | Epigenetic Alterations | However, 3 untranslated regions (3 UTR) mutations can also disrupt or create miRNA target sites, and trigger oncogene activation or tumor suppressor inactivation. | 28704519 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Long noncoding RNA linc00346 promotes the malignant phenotypes of bladder cancer. | 28705739 |
| Carcinoma, Malignant neoplasm of urinary bladder | Epigenetic Alterations | More and more reports have demonstrated that long noncoding RNAs (lncRNAs) play an important role in the development of a variety of carcinomas, including bladder cancer. | 28705739 |
| Esophageal carcinoma | Epigenetic Alterations | Therefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer. | 28707457 |
| Esophageal carcinoma | Epigenetic Alterations | Clinical value of integrated-signature miRNAs in esophageal cancer. | 28707457 |
| Esophageal carcinoma | Epigenetic Alterations | Analysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer. | 28707457 |
| Neoplasms | Epigenetic Alterations | Recent studies have revealed that microRNAs (miRNAs) play important roles as oncogenes or tumor suppressors in tumorigenesis and tumor development, by negatively regulating protein expression. | 28708205 |
| Breast Carcinoma | Epigenetic Alterations | Epigenetic Changes of the ESR1 Gene in Breast Tissue of Healthy Women: A Missing Link with Breast Cancer Risk Factors? | 28708432 |
| Obesity, Carcinogenesis | Epigenetic Alterations | Thus, it is speculated that such ESR1 epigenetic changes may be influenced or shaped by obesity and reproductive history-related factors before and during breast carcinogenesis. | 28708432 |
| Postmenopausal state | Epigenetic Alterations | These findings provide new hints about the relationship between epigenetic changes within the ESR1 gene CpG island and postmenopausal obesity and aging in cancer-free women. | 28708432 |
| Endometrial Carcinoma, Neoplasms | Epigenetic Alterations | Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity and reduced recurrence-free survival. | 28709704 |
| Neoplasms | Epigenetic Alterations | Tumors with MMR abnormalities by IHC or MSI and MLH1 methylation were classified as epigenetic MMR deficiency while those without MLH1 methylation were classified as probable MMR mutations. | 28709704 |
| Endometrial Carcinoma | Epigenetic Alterations | 466 endometrial cancers were classified; 75% as MMR proficient, 20% epigenetic MMR defects, and 5% as probable MMR mutations. | 28709704 |
| Neoplasms | Epigenetic Alterations | The epigenetic MMR defect tumors median volume was 10,220mm3 compared to 3321mm3 and 2,846mm3, for MMR proficient and probable MMR mutations respectively (P<0.0001). | 28709704 |
| Endometrioid tumor | Epigenetic Alterations | Endometrioid EC cases with epigenetic MMR defects had significantly reduced recurrence-free survival (RFS). | 28709704 |
| Ductal Carcinoma, Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | Concordance of DNA methylation profiles between breast core biopsy and surgical excision specimens containing ductal carcinoma in situ (DCIS). | 28711544 |
| Noninfiltrating Intraductal Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Here, we compared genome-scale DNA methylation measured in matched core biopsy and surgical specimens from DCIS, including specific DNA methylation biomarkers of subsequent invasive cancer. | 28711544 |
| Noninfiltrating Intraductal Carcinoma | Epigenetic Alterations | Our results indicate that DNA methylation measured in core biopsies are representative of the matched surgical specimens and suggest that DCIS biomarkers measured in core biopsies can inform clinical decision-making. | 28711544 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | The miRNAs function either as tumor suppressors or as oncogenes in tumorigenesis, and little is known about the clinical significance of miRNA expression profiles in oral cancers. | 28713923 |
| Malignant neoplasm of mouth | Epigenetic Alterations | The differential regulation of microRNAs is associated with oral cancer. | 28713923 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-379 inhibits metastasis and epithelial-mesenchymal transition via targeting FAK/AKT signaling in gastric cancer. | 28713929 |
| Stomach Carcinoma | Epigenetic Alterations | Accumulating evidence demonstrates that aberrant miRNAs contribute to gastric cancer (GC) development and progression. | 28713929 |
| Clinical Coordinator, Admitting diagnosis | Epigenetic Alterations | DNA methylation of two PTPRH promoter fragments was analyzed by pyrosequencing in a group of CRC, and AD patients as well as NM samples and CRC cell lines. | 28713969 |
| Clinical Coordinator | Epigenetic Alterations | The mean DNA methylation levels of these two regions were significantly higher in CRC than in NM. | 28713969 |
| Colorectal Neoplasms | Epigenetic Alterations | The results indicate that PTPRH is downregulated in colorectal tumors and its expression is epigenetically regulated via DNA methylation and chromatin modifications. | 28713969 |
| Primary malignant neoplasm | Epigenetic Alterations | Genes encoding different RPTPs are affected by aberrant epigenetic regulation in cancer. | 28713969 |
| Neoplasms | Epigenetic Alterations | MicroRNAs regulate the expression of genes involved in several important cancer-related processes including cell adhesion, proliferation, and tumour angiogenesis. | 28714375 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation-based immune response signature improves patient diagnosis in multiple cancers. | 28714863 |
| Breast Carcinoma | Epigenetic Alterations | Here, we profiled DNA methylation markers to identify a methylation of TIL (MeTIL) signature that recapitulates TIL evaluations and their prognostic value for long-term outcomes in breast cancer (BC). | 28714863 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Effect of microRNA-135a on Cell Proliferation, Migration, Invasion, Apoptosis and Tumor Angiogenesis Through the IGF-1/PI3K/Akt Signaling Pathway in Non-Small Cell Lung Cancer. | 28715819 |
| Malignant Neoplasms, Metastasis | Epigenetic Alterations | Aberrant microRNA expression has been implicated in metastasis of cancers. | 28716024 |
| Carcinogenesis | Epigenetic Alterations | Epigenetic changes, including DNA methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis. | 28716111 |
| Malignant Neoplasms, ovarian neoplasm | Epigenetic Alterations | Two microRNA signatures for malignancy and immune infiltration predict overall survival in advanced epithelial ovarian cancer. | 28716985 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | MicroRNAs have been established as key regulators of tumor gene expression and as prime biomarker candidates for clinical phenotypes in epithelial ovarian cancer (EOC). | 28716985 |
| Neoplasms | Epigenetic Alterations | We analyzed the coexpression and regulatory structure of microRNAs and their co-localized gene targets in primary tumor tissue of 20 patients with advanced EOC in order to construct a regulatory signature for clinical prognosis. | 28716985 |
| Primary malignant neoplasm | Epigenetic Alterations | We validated the prognostic relevance of the immunological module microRNAs in the publicly available The Cancer Genome Atlas data set. | 28716985 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | Evaluation of epigenetic inactivation of vascular endothelial growth factor receptors in head and neck squamous cell carcinoma. | 28718364 |
| Pituitary Adenoma | Epigenetic Alterations | RIZ1 and histone methylation status in pituitary adenomas. | 28718376 |
| Pituitary Adenoma | Epigenetic Alterations | Promoter region methylation of RIZ1 may play an important role in the epigenetic silencing of RIZ1 expression in pituitary adenomas, which may translate into important diagnostic and therapeutic applications. | 28718376 |
| Neoplasms, Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2. | 28718378 |
| Glioblastoma Multiforme | Epigenetic Alterations | Overexpression of microRNA-613 in the glioblastoma cell lines U87 and U251 retarded cell growth and induced cell apoptosis. | 28718378 |
| Glioblastoma Multiforme | Epigenetic Alterations | Upregulation of microRNA-613 inhibited glioblastoma cell clone formation, invasion and migration. | 28718378 |
| Glioblastoma Multiforme | Epigenetic Alterations | Furthermore, we demonstrated that arginase-2 was directly regulated by microRNA-613 and played an essential role in mediating the biological effects of microRNA-613 in glioblastoma. | 28718378 |
| Glioblastoma Multiforme | Epigenetic Alterations | Re-expression of arginase-2 markedly reversed the inhibitory properties of microRNA-613 in glioblastoma cells. | 28718378 |
| Glioblastoma Multiforme | Epigenetic Alterations | Taken together, our data provide compelling evidence that human cytomegalovirus reduced the level of microRNA-613 which functions as an anti-onco-miRNA in glioblastoma, primarily by downregulating the expression of arginase-2. | 28718378 |
| Inflammation Mediators, Admitting diagnosis, "Alzheimers Disease", Down Syndrome | Epigenetic Alterations | We hypothesized that an inflammation-mediated dysregulation of these miRNAs may occur in patients with Down syndrome (DS) and Alzheimers disease (AD). | 28720071 |
| Admitting diagnosis | Epigenetic Alterations | In particular, we provide evidence of a dysregulation of these two immunomodulatory miRNAs in AD with a potential therapeutical implication, deserving further investigation. | 28720071 |
| Stomach Carcinoma | Epigenetic Alterations | Plasma microRNA-based signatures to predict 3-year postoperative recurrence risk for stage II and III gastric cancer. | 28722210 |
| Stomach Carcinoma | Epigenetic Alterations | Our aim was to identify plasma microRNA (miRNA)-based signatures to predict 3-year postoperative recurrence risk for patients with stage II and III gastric cancer (GC), so as to provide insights for individualized adjuvant therapy. | 28722210 |
| Hypoxia, Cerebrovascular accident | Epigenetic Alterations | Levels of all 3 microRNAs depended on platelet numbers in a platelet spike-in experiment but were unaffected by chemical hypoxia in Neuro2a cells and in experimental stroke models. | 28724745 |
| Graves Disease | Epigenetic Alterations | In the Graves disease patients, altered DNA methylation profile and modified age prediction accuracy were noted for TRIM59 and FHL2 with aberrant hypermethylation observed for the former and aberrant hypomethylation for the latter. | 28725932 |
| Tetranitromethane, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Age at surgery (hazard ratio [HR] 1.021, 95% confidence interval [CI] 1.003-1.040), TNM stages II (HR 3.858, 95% CI 2.449-6.078) and III (HR 3.099, 95% CI 1.911-5.023), and miRNA-21 (HR 1.002, 95% CI 1.001-1.003) and miRNA-155 expression (HR 1.131, 95% CI 1.064-1.202) were independent prognostic factors in NSCLC patients. | 28727276 |
| Tetranitromethane, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MiRNA-21 expression with TNM stages II (HR 1.282, 95% CI 1.197-1.372) and III (HR 1.247, 95% CI 1.149-1.354) interacted to affect prognosis in NSCLC patients. | 28727276 |
| Tetranitromethane, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Older age, higher clinical TNM stage, and increased miRNA-21 and miRNA-155 expression in NSCLC tissue were independently associated with poor survival in NSCLC patients. | 28727276 |
| Tetranitromethane | Epigenetic Alterations | MiRNA-21 expression and clinical TNM stage interacted to affect prognosis. | 28727276 |
| Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Epigenetic Alterations | DNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome. | 28727822 |
| Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent, ETV3 wt Allele, Metabolic Syndrome X | Epigenetic Alterations | The prevalence of type 2 diabetes (T2D) and the metabolic syndrome (MetS) is increasing and several studies suggested an involvement of DNA methylation in the development of these metabolic diseases. | 28727822 |
| Diabetes Mellitus, Non-Insulin-Dependent, ETV3 wt Allele | Epigenetic Alterations | Altered levels of DNA methylation in PBLs of specific loci might serve as a biomarker for T2D or MetS, although further investigation is required. | 28727822 |
| Clinical Coordinator | Epigenetic Alterations | Aberrant DNA methylation of CpG islands occurred frequently in CRC and associated with transcriptional silencing of key genes. | 28730335 |
| Breast Carcinoma | Epigenetic Alterations | The regulatory role of RSK4 in breast cancer development was mediated by AKT and extracellular signal-regulated kinase (ERK) signaling pathways and the expression of RSK4 was altered by DNA methylation in promoter regions. | 28731146 |
| Periodontal Diseases | Epigenetic Alterations | Periodontal therapy resets the DNA methylation status of inflammatory gene for COX-2 in patients with periodontal disease. | 28736819 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have been consistently demonstrated to be involved in colorectal cancer as either tumour oncogenes or tumour suppressors. | 28738328 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | microRNA-125b (miR-125b) has been reported to be increased in rheumatoid arthritis (RA). | 28738524 |
| Metastatic melanoma, melanoma | Epigenetic Alterations | Here, we reported miR-23a as a novel metastasis-associated miRNA that played a remarkable role in modulating melanoma invasive and metastatic capacity and was of great value in predicting melanoma metastasis and prognosis. | 28740547 |
| Metastasis, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Recently, microRNAs (miRNAs) have been implicated in modulating cancer invasion and metastasis, and are proved as potential non-invasive biomarkers in sera for various tumors. | 28740547 |
| Malignant Neoplasms | Epigenetic Alterations | One of these miRNAs, miR-144 has been found aberrantly expressed in a variety of human malignancies. | 28742204 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | Up-regulation of long non-coding RNA PCAT-1 correlates with tumor progression and poor prognosis in gastric cancer. | 28742205 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Whole blood microRNA expression may not be useful for screening non-small cell lung cancer. | 28742859 |
| Carcinoma of lung | Epigenetic Alterations | At least seven studies have suggested that microRNA levels in whole blood can be diagnostic for lung cancer. | 28742859 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | Additionally, no difference for microRNA expression was noticed in microarray-based microRNA profiles of whole blood of 12 stage IA-IIIB NSCLC cases before and three-four weeks after tumor resection. | 28742859 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | These findings show that whole blood microRNA expression profiles lack diagnostic value for high-risk screening of NSCLC, though such value may exist for selective sub-groups of NSCLC and control populations. | 28742859 |
| Carcinoma of lung, Lung mass, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Qiagen(r) PAXgene(tm) Blood miRNA System was used to collect blood and extract RNA from it for 85 pathologic stage I-IV non-small cell lung cancer (NSCLC) cases and 76 clinically-relevant controls who had a benign pulmonary mass, or a high risk of developing lung cancer because of a history of cigarette smoking or age >60 years. | 28742859 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | In this work, a negative correlation between DDR1 and a tumor suppressor miRNA, miR-199a-3p, was observed in ovarian cancer tissues. | 28743276 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Somatic mutation, DNA copy number, DNA methylation, gene expression, and protein array data from the TCGA lower-grade glioma database were analyzed for molecular-radiographic associations. | 28751449 |
| Coronary Artery Disease | Epigenetic Alterations | Circulating microRNAs (miRNAs/miRs) are regulated in patients with coronary artery disease. | 28751542 |
| NSD1 protein, human | Epigenetic Alterations | Through an integrative analysis, we discovered frequent silencing of the histone H3 K36 methyltransferase NSD1 as the sole chromatin-modifying gene silenced by DNA methylation in ccRCC. | 28754676 |
| NSD1 protein, human, "Sotos syndrome | Epigenetic Alterations | ccRCC harboring epigenetic silencing of NSD1 displayed a specific genome-wide methylome signature consistent with the NSD1 mutation methylome signature observed in Sotos syndrome. | 28754676 |
| IL13 gene | Epigenetic Alterations | In PBMCs of allergic rhinitis participants, 42 sites showed significant DNA methylation changes of 2% or greater. | 28755526 |
| IL13 gene | Epigenetic Alterations | Blood and nasal epigenetics correlate with allergic rhinitis symptom development in the environmental exposure unit. | 28755526 |
| IL13 gene | Epigenetic Alterations | Epigenetic alterations may represent new therapeutic targets and/or biomarkers of allergic rhinitis (AR). | 28755526 |
| Chronic Kidney Diseases | Epigenetic Alterations | Cholesterol lowering treatment restores blood global DNA methylation in chronic kidney disease (CKD) patients. | 28755807 |
| Chronic Kidney Diseases | Epigenetic Alterations | DNA methylation was significantly lower in CKD patients vs. controls (4.06 +- 0.20% vs. 4.27 +- 0.17% mCyt, p = 0.0001). | 28755807 |
| Chronic Kidney Diseases | Epigenetic Alterations | Our results demonstrate that CKD patients have a lower degree of DNA methylation and that cholesterol lowering treatment restores mCyt DNA concentrations to levels similar to healthy controls. | 28755807 |
| 1-methyl-1-piperidinomethane sulfonate | Epigenetic Alterations | miRNA-16, miRNA-17, and miRNA-486 in plasma and tissue of MPM patients were significantly correlated. | 28757678 |
| Disease | Epigenetic Alterations | All the miRNA levels were decreased in patients with MPM or ASB, supporting the role of circulating miRNAs as a potential tool for diseases associated with exposure to asbestos fibers. | 28757678 |
| 1-methyl-1-piperidinomethane sulfonate, Malignant Pleural Mesothelioma, Asbestosis | Epigenetic Alterations | To identify a pattern of miRNAs as possible diagnostic biomarkers for patients with malignant pleural mesothelioma (MPM) and asbestosis (ASB) and as prognostic biomarkers for MPM patients. | 28757678 |
| Pancreatic carcinoma, Neoplasms | Epigenetic Alterations | Our findings showed that miR-377 through targeting DNMT1 could reduce DNA methylation of some tumor suppressor genes and restore their expression in pancreatic cancer cells. | 28758420 |
| Neoplasms | Epigenetic Alterations | The frequency and timing of chemo brain and tumor brain occurrence and persistence strongly suggest they may be epigenetic in nature and associated with altered gene expression. | 28758896 |
| Colorectal Carcinoma, Neoplasms | Epigenetic Alterations | Down-regulated long non-coding RNA SNHG1 inhibits tumor genesis of colorectal carcinoma. | 28759957 |
| Clinical Coordinator, Colorectal Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Colorectal carcinoma (CRC) is the vital cancer mortality worldwide and the long noncoding RNAs (lncRNAs) is considered as an important biomarker. | 28759957 |
| Pancreatic carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Circulating microRNAs (miRNAs) are emerging as novel biomarkers for various types of cancer including pancreatic cancer (PC). | 28759959 |
| Dilated Cardiomyopathy Pathway | Epigenetic Alterations | Histone Modification Is Correlated With Reverse Left Ventricular Remodeling in Nonischemic Dilated Cardiomyopathy. | 28760462 |
| Heart failure | Epigenetic Alterations | It has been shown that epigenetic modification, such as methylation or acetylation of the histone, is one of the most important upstream signals in cardiac failure. | 28760462 |
| Primary malignant neoplasm | Epigenetic Alterations | Long Noncoding RNA NEAT1 Promotes Proliferation and Invasion via Targeting miR-181a-5p in Non-Small Cell Lung Cancer. | 28762332 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The relationship between DNA-methylation and high-grade PCa was examined in a cohort of 102 prospectively enrolled men who received standard 12-core prostate biopsies. | 28762545 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA-methylation intensities of GSTP1, RASSF1, and APC were higher in biopsy cores from men diagnosed with GS >= 7 cancer compared to men with diagnosed GS 6 disease. | 28762545 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | In men diagnosed with PCa, DNA-methylation profiling can detect under-sampled high-risk PCa in prostate biopsy specimens through a field effect. | 28762545 |
| Prostate Cancer Pathway | Epigenetic Alterations | Epigenetic risk score improves prostate cancer risk assessment. | 28762545 |
| melanoma | Epigenetic Alterations | MT1A is aberrantly silenced by DNA methylation of 5 MT1A CGI in melanoma. | 28764861 |
| Degenerative polyarthritis | Epigenetic Alterations | Identification of differentially expressed microRNAs in knee anterior cruciate ligament tissues surgically removed from patients with osteoarthritis. | 28765881 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Down-regulation of long noncoding RNA RP11-713B9.1 contributes to the cell viability in non-small cell lung cancer (NSCLC). | 28765887 |
| Primary malignant neoplasm | Epigenetic Alterations | Recent studies have demonstrated that long noncoding RNAs (lncRNAs) serve important roles in cancer occurrence and progression. | 28765887 |
| Primary malignant neoplasm | Epigenetic Alterations | Non-coding RNA 886 (nc886) has been suggested to serve tumor-suppressing roles in several cancer cells. | 28765891 |
| Breast Cancer Cell, Nasopharyngeal carcinoma | Epigenetic Alterations | MicroRNAs (miRs) act as important regulators during the development and progression of human cancer; however, the regulatory mechanism of miR-663 in nasopharyngeal carcinoma (NPC) remains unclear. | 28765905 |
| Malignant Neoplasms, Osteosarcoma | Epigenetic Alterations | MicroRNA-635 inhibits the malignancy of osteosarcoma by inducing apoptosis. | 28765920 |
| Clinical Coordinator | Epigenetic Alterations | In addition, bioinformatics methods demonstrated that PHF8 was a putative target of microRNA (miR)-488, and miR-488 was able to inhibit the expression of PHF8 in CRC cells. | 28765946 |
| Breast Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Clinical Relevance of microRNA Expressions in Breast Cancer Validated Using the Cancer Genome Atlas (TCGA). | 28766230 |
| Neoplasms | Epigenetic Alterations | MiRNA-205 has tumor suppressive properties, whereas miRNA-18a has both oncogenic and tumor suppressive roles. | 28766230 |
| Breast Carcinoma | Epigenetic Alterations | MiRNA-744s role in breast cancer is unknown but is tumor-suppressive in vitro. | 28766230 |
| Breast Carcinoma, Mammary Neoplasms, Neoplasms | Epigenetic Alterations | By utilizing a big dataset (TCGA) with sufficient statistical power, we found that high expression of miRNA-18a, miRNA-205, and miRNA-744 in the breast tumor samples were all associated with better overall survival in ER/PR-positive, lymph node-negative disease supporting their role as a tumor suppressor in breast cancer. | 28766230 |
| Breast Carcinoma, Carcinogenesis | Epigenetic Alterations | MicroRNAs (miRNAs) play a critical role in the carcinogenesis and progression of breast cancer. | 28766230 |
| Breast Carcinoma | Epigenetic Alterations | We hypothesize that high expression of all three miRNAs is associated with a better survival based on their known functions in breast cancer. | 28766230 |
| Subarachnoid Hemorrhage | Epigenetic Alterations | MicroRNA Changes in Cerebrospinal Fluid After Subarachnoid Hemorrhage. | 28768799 |
| S-Adenosylhomocysteine | Epigenetic Alterations | MiRNA profiles from 27 SAH patients and 10 neurologically healthy patients passed quality control. | 28768799 |
| S-Adenosylhomocysteine | Epigenetic Alterations | SAH is associated with marked changes in the cerebrospinal fluid miRNA profile. | 28768799 |
| Cerebral Ischemia | Epigenetic Alterations | MicroRNAs (miRNAs) are pathophysiologically involved in acute cerebral ischemia. | 28768799 |
| Noninfiltrating Intraductal Carcinoma, S-Adenosylhomocysteine | Epigenetic Alterations | In the validation, 66 miRNAs showed a relative increase in cerebrospinal fluid from SAH patients compared with neurologically healthy patients (P<0.001); 2 (miR-21 and miR-221) showed a relative increase in SAH patients with DCI compared with those without (P<0.05) in both the screening and validation. | 28768799 |
| Papillary thyroid carcinoma | Epigenetic Alterations | The expression and function of long noncoding RNA lncRNA-ATB in papillary thyroid cancer. | 28770959 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | SOCS3 was found significantly declined, while microRNA-221 (miR-221) obviously up-regulated in bladder cancer tissue. | 28770966 |
| Primary malignant neoplasm | Epigenetic Alterations | miR-125a-3p is a non-coding RNA that can reduce cell proliferation and migration in cancer. | 28771224 |
| Malignant neoplasm of liver | Epigenetic Alterations | On the basis of our previous research, FUT can be regulated by miRNA, which influences the proliferation and invasion of breast and hepatocellular cancer cells. | 28771224 |
| Malignant tumor of colon | Epigenetic Alterations | MicroRNA-27a Promotes the Proliferation and Invasiveness of Colon Cancer Cells by Targeting SFRP1 through the Wnt/b-Catenin Signaling Pathway. | 28772260 |
| Imprinting (Psychology), Alloisoleucine | Epigenetic Alterations | Loss of imprinting (LOI) is an epigenetic event that relaxes an allele-specific restriction on gene expression. | 28775169 |
| Multiple Myeloma, Lipoma | Epigenetic Alterations | As a CpG island is absent in miR-28-5- but present in its host gene, LPP (LIM domain containing preferred translocation partner in lipoma), we hypothesized that miR-28-5p is epigenetically silenced by promoter DNA methylation of its host gene in multiple myeloma. | 28775176 |
| Malignant Neoplasms | Epigenetic Alterations | This is the first report of epigenetic regulation of the intronic miR-28-5p expression by promoter DNA methylation of its host gene, hence warrants further study in different cancers. | 28775176 |
| Multiple Myeloma | Epigenetic Alterations | Epigenetic silencing of LPP/miR-28 in multiple myeloma. | 28775176 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | miR-28-5- is a tumour suppressor microRNA implicated in cancers. | 28775176 |
| Plaque, Atherosclerotic | Epigenetic Alterations | Atherosclerotic plaque rupture is accompanied by an acute decrease in the carotid plaque expression of micro-RNAs (miRs)-221 and miR-222. | 28779016 |
| Squamous cell carcinoma | Epigenetic Alterations | Four PTEN-targeting co-expressed miRNAs and ACTN4- targeting miR-548b are independent prognostic biomarkers in human squamous cell carcinoma of the oral tongue. | 28779483 |
| Primary malignant neoplasm | Epigenetic Alterations | These findings were validated in The Cancer Genome Atlas (TCGA) cohort (n = 131) for both miRNAs (miR-548b: p = 0.027; miR-18a: p = 0.001). | 28779483 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Down-regulation of microRNA-224 -inhibites growth and epithelial-to-mesenchymal transition phenotype -via modulating SUFU expression in bladder cancer cells. | 28780419 |
| Secondary malignant neoplasm of pancreas | Epigenetic Alterations | YB-1 expression promotes pancreatic cancer metastasis that is inhibited by microRNA-216a. | 28782557 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Down-regulation of long non-coding RNA MEG3 indicates an unfavorable prognosis in non-small cell lung cancer: Evidence from the GEO database. | 28782577 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-1297 contributes to tumor growth of human breast cancer by targeting PTEN/PI3K/AKT signaling. | 28791363 |
| Breast Carcinoma | Epigenetic Alterations | Increasing evidence confirms that aberrant miRNA expression contributes to breast cancer (BC) development and progression. | 28791363 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression. | 28791371 |
| Tetranitromethane, Metastasis | Epigenetic Alterations | We used an integrative computational method to identify LUAD-specific key miRNAs related to TNM stage and lymphatic metastasis from the TCGA database. | 28791371 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-212 functions as a tumor-suppressor in human non-small cell lung cancer by targeting SOX4. | 28791372 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Increasing evidence has revealed that aberrant expression of miRNAs contributes to non-small cell lung cancer (NSCLC) development and progression. | 28791372 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | However, the roles and mechanisms of various miRNAs in NSCLC remain to be determined. | 28791372 |
| Breast Cancer Cell, HOXA11-AS gene, Metastasis | Epigenetic Alterations | Long non-coding RNA HOXA11-AS promotes cell proliferation and metastasis in human breast cancer. | 28791375 |
| Malignant Neoplasms, Breast Carcinoma | Epigenetic Alterations | Long non-coding RNAs (LncRNAs) have previously been demonstrated to be important in multiple cancers, including breast cancer. | 28791375 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer. | 28791380 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain-derived neurotrophic factor. | 28791400 |
| Stomach Carcinoma | Epigenetic Alterations | It has previously been demonstrated that microRNAs (miRNAs) are actively involved in the pathogenesis of gastric cancer. | 28791400 |
| Stomach Carcinoma | Epigenetic Alterations | Therefore, miRNAs have been proposed as promising therapeutic targets in gastric cancer patients. | 28791400 |
| Carcinoma of larynx | Epigenetic Alterations | MicroRNA-195 inhibits growth and invasion of laryngeal carcinoma cells by directly targeting DCUN1D1. | 28791411 |
| Lung Neoplasms, Colorectal Cancer Pathway | Epigenetic Alterations | Smoking has been reported to be associated with changes in DNA methylation in blood and in lung tumour tissues, although there has been scant investigation of how epigenetic factors may be implicated in the increased risk of developing colorectal cancer. | 28791728 |
| Smoking Behaviors, Colorectal Neoplasms | Epigenetic Alterations | To identify epigenetic changes associated with smoking behaviours, we performed epigenome-wide analysis of DNA methylation in colorectal tumours from 36 never-smokers, 47 former smokers, and 13 active smokers, and in adjacent mucosa from 49 never-smokers, 64 former smokers, and 18 active smokers. | 28791728 |
| Intervertebral Disc Degeneration | Epigenetic Alterations | MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration. | 28793234 |
| Intervertebral disc disorder, Intervertebral Disc Degeneration | Epigenetic Alterations | MicroRNAs (miRNAs) have been shown to be involved in the pathogenesis of intervertebral disc degeneration (IDD). | 28793234 |
| Primary malignant neoplasm | Epigenetic Alterations | The microRNA (miR)-302 family consisting four members, miR-302a, miR-302b, miR-302c and miR-302d, plays an important role in diverse biological processes, and regulates many pathological changes, including cancer. | 28795345 |
| Clinical Coordinator, Colorectal Cancer Pathway, Malignant Neoplasms, Inflammation | Epigenetic Alterations | Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, which is a heterogeneous disease and main risk factors are associated with inflammation, family history, genetic mutations, epigenetics, and so on. | 28796265 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Effects of long noncoding RNA SPRY4-IT1-mediated EZH2 on the invasion and migration of lung adenocarcinoma. | 28796375 |
| Antilymphocyte Serum, Amyotrophic Lateral Sclerosis | Epigenetic Alterations | Epigenetic differences between monozygotic twins discordant for amyotrophic lateral sclerosis (ALS) provide clues to disease pathogenesis. | 28797086 |
| Muscular Atrophy, Antilymphocyte Serum | Epigenetic Alterations | Here we report the epigenetic profiling of five monozygotic twin pairs discordant for ALS, four with classic ALS and one with the progressive muscular atrophy ALS variant, in whom previous whole genome sequencing failed to uncover a genetic basis for their disease discordance. | 28797086 |
| Liver carcinoma | Epigenetic Alterations | Long noncoding RNA PVT1 promotes hepatocellular carcinoma progression through regulating miR-214. | 28800314 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | Long noncoding RNAs (lncRNA) have been verified to be involved in hepatocellular carcinoma (HCC) progression. | 28800314 |
| Malignant Neoplasms, Carcinoma of lung | Epigenetic Alterations | Studies suggest an important role of microRNAs (miRNAs) in a variety of cancers, including lung cancer. | 28800790 |
| Neoplasms | Epigenetic Alterations | The detection of recurrent KMT2D/MLL2 alterations implicates epigenetic regulation in the pathogenesis of HS and supports the notion of transdifferentiation from a genetically similar but phenotypically distinct tumor of a different lineage. | 28805986 |
| Cataract | Epigenetic Alterations | This miRNA-TATA-box/3 UTR-gene-regulation network may contribute to cataract pathogenesis. | 28806956 |
| Cataract | Epigenetic Alterations | RNAhybrid online tool was applied to predict the binding between significantly regulated miRNAs in cataract lenses and target mRNAs. | 28806956 |
| Lung Diseases, Obstructive | Epigenetic Alterations | MicroRNA-181c inhibits cigarette smoke-induced chronic obstructive pulmonary disease by regulating CCN1 expression. | 28806967 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Accumulating evidence has shown that the dysregulation of miRNAs is crucially involved in the pathogenesis and development of COPD. | 28806967 |
| Injury wounds | Epigenetic Alterations | MicroRNA-132 with Therapeutic Potential in Chronic Wounds. | 28807666 |
| diabetic, diabetic ulcer | Epigenetic Alterations | We found significantly reduced microRNA-132 (miR-132) expression in human diabetic ulcers compared with normal skin wounds and also in skin wounds of leptin receptor-deficient (db/db) diabetic mice compared with wild-type mice. | 28807666 |
| Primary malignant neoplasm | Epigenetic Alterations | The data of miRNA expression, mRNA expression and DNA methylation were downloaded from The Cancer Genome Atlas. | 28809126 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Comprehensive epigenetic analysis of the signature genes in lung adenocarcinoma. | 28809126 |
| Adenocarcinoma of lung (disorder) | Epigenetic Alterations | Taken together, the epigenetic alterations of signature genes may hold promise for becoming biomarkers for the early detection of lung adenocarcinoma. | 28809126 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant DNA methylation is a hallmark of many cancers. | 28809778 |
| Neoplasms | Epigenetic Alterations | This approach suggests that DNA methylation status in CGIs of some tumor suppressor genes could be driven by E2 availability, subsequently inducing the activation of the ERa pathway. | 28809778 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Dynamic plasma microRNAs are biomarkers for prognosis and early detection of recurrence in colorectal cancer. | 28809863 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Plasma microRNAs (miRNAs) are promising non-invasive biomarkers for colorectal cancer (CRC) prognosis. | 28809863 |
| Ototoxicity | Epigenetic Alterations | This study demonstrates that CpG-specific DNA methylation in the ERCC3 promoter region may be involved in benzene-induced epigenetic modification and it may contribute to benzene-induced hematotoxicity. | 28813025 |
| Ototoxicity | Epigenetic Alterations | In order to test whether specific CpG sites of ERCC3 play an important role in benzene-induced epigenetic changes and whether the specific methylation patterns are associated with benzene hematotoxicity, we analyzed the promoter methylation levels of individual CpG sites, transcription factor binding motif and the correlation between aberrant CpG methylation and hematotoxicity in 76 benzene-exposed workers and 24 unexposed controls in China. | 28813025 |
| Neoplasms | Epigenetic Alterations | Collectively, these findings revealed that TUG1 functions as an oncogenic lncRNA that promotes tumor progression, at least partially, by functioning as an endogenous sponge and competing for miR-382 binding to the miRNA target EZH2. | 28813705 |
| SERPINB3 wt Allele | Epigenetic Alterations | Our data highlight the importance of CpG location and correct estimation of DNA methylation level for highly accurate early diagnosis of OSCC. | 28814981 |
| Liver carcinoma, Hollings Cancer Center, Metastasis, Primary malignant neoplasm | Epigenetic Alterations | Metastasis is the major cause of the poor prognosis of hepatocellular carcinoma (HCC), and increasing evidence supports the contribution of miRNAs to cancer progression. | 28817119 |
| Carcinoma of lung, Metastasis | Epigenetic Alterations | Downregulation of MicroRNA-330 Correlates with the Radiation Sensitivity and Prognosis of Patients with Brain Metastasis from Lung Cancer. | 28817811 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Blood global DNA methylation is decreased in non-severe chronic obstructive pulmonary disease (COPD) patients. | 28818709 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | DNA methylation was significantly lower in COPD patients vs. controls (4.20 +- 0.18% mCyt vs. 4.29 +- 0.18% mCyt, p = 0.02). | 28818709 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Furthermore, DNA methylation in COPD patients with moderate disease was significantly lower than that in patients with mild disease (4.14 +- 0.15% mCyt vs. 4.23 +- 0.19% mCyt, p < 0.05). | 28818709 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | The presence and severity of COPD is associated with progressively lower DNA methylation in blood. | 28818709 |
| Cardiac Arrest | Epigenetic Alterations | Initial studies suggested that miRNAs, such as the brain-enriched miR-124-3p, might improve outcome prediction after out-of-hospital cardiac arrest. | 28819446 |
| Primary malignant neoplasm | Epigenetic Alterations | 5-Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification that has been linked to gene regulation and cancer pathogenesis. | 28820176 |
| Liver diseases | Epigenetic Alterations | Actually, several miRNAs have been reported to be biomarker candidates of liver diseases. | 28823616 |
| Liver diseases | Epigenetic Alterations | The profiling of the selected miRNAs can be useful to distinguish different types of liver diseases. | 28823616 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Altered epigenetic features in circulating nucleosomes in idiopathic pulmonary fibrosis. | 28824731 |
| Fibrosis Assessment | Epigenetic Alterations | Polymorphisms and environmentally induced epigenetic variations seem to determine individual susceptibility to the development of lung fibrosis. | 28824731 |
| Idiopathic Pulmonary Fibrosis | Epigenetic Alterations | Moreover, we found differences in epigenetic profiles between untreated IPF patients and those receiving anti-fibrotic therapy with mH2A1.1 and 5mC being significantly lower in untreated than in treated patients (p < 0.01 and p < 0.05, respectively). | 28824731 |
| membrane attack complex location, Lung diseases | Epigenetic Alterations | MicroRNA (miRNA) has been recently recognized as a biomarker of various diseases; however, there are no known miRNAs associated with Mycobacterium avium complex (MAC) pulmonary disease. | 28827075 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Long noncoding RNA linc-ITGB1 (linc-ITGB1) was reported to serve as a tumor promoter in breast cancer (BC). | 28829502 |
| CO-methylating acetyl-CoA synthase activity, Nonstress test, Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | To this end, we applied gene chip technology to analyze miRNA expression in patients with stable angina (SA), non-ST elevation ACS (NSTE-ACS), and ST-segment elevation myocardial infarction (STEMI). | 28830367 |
| Inflammation | Epigenetic Alterations | Compared with those in patients with STEMI, differentially expressed microRNAs in controls and patients with SA or NSTE-ACS were involved in inflammation, protein phosphorylation, and cell adhesion. | 28830367 |
| CO-methylating acetyl-CoA synthase activity, Acute Coronary Syndrome | Epigenetic Alterations | However, it is unclear whether miRNAs can be used as biomarkers for acute coronary syndrome (ACS). | 28830367 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Malignant cells in AML often exhibit chromosomal and other genetic or epigenetic abnormalities that are useful in prognostic risk assessment. | 28834593 |
| Primary malignant neoplasm | Epigenetic Alterations | Long Noncoding RNA PlncRNA-1 Promotes Colorectal Cancer Cell Progression by Regulating the PI3K/Akt Signaling Pathway. | 28835319 |
| Malignant Neoplasms | Epigenetic Alterations | Accumulating evidence has indicated that long noncoding RNA (lncRNA) PlncRNA-1 plays an important regulatory role in cancers. | 28835319 |
| Colorectal Cancer Pathway | Epigenetic Alterations | CCAT1 and CCAT2 long noncoding RNAs, located within the 8q.24.21 gene desert, serve as important prognostic biomarkers in colorectal cancer. | 28838211 |
| Neuroendocrine Tumors | Epigenetic Alterations | Frequent silencing of RASSF1A by DNA methylation in thymic neuroendocrine tumours. | 28838380 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Aberrant methylation of promoter CpG islands (CGIs) of tumour suppressor genes is a common epigenetic mechanism underlying cancer pathogenesis. | 28838380 |
| Neuroendocrine Tumors | Epigenetic Alterations | Herein, we sought to identify genes that could serve as epigenetic targets for thymic neuroendocrine tumour (NET) therapy. | 28838380 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma. | 28844099 |
| Hollings Cancer Center | Epigenetic Alterations | Thus, PRSS3 is a potential prognostic biomarker and an epigenetic target for intervention of human HCC. | 28844099 |
| Hollings Cancer Center | Epigenetic Alterations | * Epigenetic silencing of PRSS3 facilitates growth, migration, and invasion of HCC. | 28844099 |
| Ulcerative Colitis-Associated Colorectal Adenocarcinoma | Epigenetic Alterations | A Panel of Methylated MicroRNA Biomarkers for Identifying High-Risk Patients With Ulcerative Colitis-Associated Colorectal Cancer. | 28847750 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Gene Expression, DNA Methylation and Prognostic Significance of DNA Repair Genes in Human Bladder Cancer. | 28848075 |
| Neoplasms | Epigenetic Alterations | High grade tumors had significantly lower levels of global DNA methylation (P=0.04). | 28848075 |
| diabetic | Epigenetic Alterations | Effect of the Diabetic Environment On the Expression of MiRNAs in Endothelial Cells: Mir-149-5p Restoration Ameliorates the High Glucose-Induced Expression of TNF-a and ER Stress Markers. | 28848152 |
| Metastasis, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Long non-coding RNA Z38 promotes cell proliferation and metastasis in human renal cell carcinoma. | 28849012 |
| Malignant Neoplasms, Malignant neoplasm of kidney, Refractory Cytopenia of Childhood, Renal Cell Carcinoma Pathway | Epigenetic Alterations | Long non-coding RNAs (LncRNAs) have been reported to serve roles in various types of malignancy, including human renal cell carcinoma (RCC), which is among the most common types of kidney cancer worldwide. | 28849012 |
| Liver carcinoma | Epigenetic Alterations | MicroRNA-302a inhibits cell proliferation and invasion, and induces cell apoptosis in hepatocellular carcinoma by directly targeting VEGFA. | 28849033 |
| Malignant Neoplasms, Hollings Cancer Center | Epigenetic Alterations | An increasing number of studies have demonstrated that microRNAs may be used as diagnostic, therapeutic and prognostic targets for human cancers, including HCC. | 28849033 |
| Admitting diagnosis | Epigenetic Alterations | The results indicated that there were 35 strips of microRNA in the mild AD group, in which the difference of expression signal was >500 IU/ml. | 28849039 |
| Admitting diagnosis | Epigenetic Alterations | It was concluded that microRNA-222 may affect the occurrence and development of AD through a variety of mechanisms, and may serve as a biomarker for the early diagnosis of AD. | 28849039 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-543 inhibits proliferation, invasion and induces apoptosis of glioblastoma cells by directly targeting ADAM9. | 28849046 |
| Primary malignant neoplasm, Glioblastoma Multiforme | Epigenetic Alterations | The abnormal expression of microRNAs (miRs) has been reported to be important in the formation and progression of various types of human cancer, including glioblastoma (GBM). | 28849046 |
| Papillary thyroid carcinoma | Epigenetic Alterations | MicroRNA-497 inhibits cellular proliferation, migration and invasion of papillary thyroid cancer by directly targeting AKT3. | 28849051 |
| Papillary thyroid carcinoma, Neoplasms, F9 gene | Epigenetic Alterations | Emerging studies have indicated the critical roles of microRNAs (miRs) in papillary thyroid cancer (PTC) formation and progression through function as tumor suppressors or oncogenes. | 28849051 |
| Osteosarcoma | Epigenetic Alterations | MicroRNA-643 regulates the expression of ZEB1 and inhibits tumorigenesis in osteosarcoma. | 28849077 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | Downregulation of microRNA-15a suppresses the proliferation and invasion of renal cell carcinoma via direct targeting of eIF4E. | 28849086 |
| Neoplasms | Epigenetic Alterations | The downregulation of microRNA-15a has been reported in several human tumors. | 28849086 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues. | 28849087 |
| Malignant Neoplasms | Epigenetic Alterations | The long non-coding RNAs (lncRNAs) recently have been considered as key regulators of tumor malignant. | 28849087 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | The clinical significance of microRNA (miR)-136-5p in hepatocellular carcinoma (HCC) has not been verified. | 28849100 |
| Hollings Cancer Center | Epigenetic Alterations | miR-136-5p may act as an anti-carcinoma miRNA, which is essential for HCC progression through the regulation of various signaling pathways. | 28849100 |
| Neoplasms, Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB. | 28849154 |
| Hypertensive disease | Epigenetic Alterations | Therefore, other modified factors, including environmental factors, and nuclear gene and epigenetic modifications, may be involved in the pathogenesis of hypertension. | 28849157 |
| Pancreatitis | Epigenetic Alterations | Screening and validation of differentially expressed extracellular miRNAs in acute pancreatitis. | 28849189 |
| Barrett Esophagus | Epigenetic Alterations | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barretts esophagus. | 28852310 |
| Barrett Esophagus | Epigenetic Alterations | These microRNAs were also more highly expressed in Barretts esophagus mucosa than matched proximal squamous and squamous mucosa from controls. | 28852310 |
| Barrett Esophagus | Epigenetic Alterations | Neosquamous mucosa arising after ablation of Barretts esophagus expresses microRNAs that may contribute to decreased barrier function and microRNAs that may be involved in the regulation of survival signaling pathways. | 28852310 |
| Malignant Neoplasms, Squamous cell carcinoma, SERPINB3 wt Allele, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Epigenetic Alterations | DNA methylation has started a recent revolution in genomics biology by identifying key biomarkers for multiple cancers, including oral squamous cell carcinoma (OSCC), the most common head and neck squamous cell carcinoma. | 28852427 |
| SERPINB3 wt Allele | Epigenetic Alterations | A multi-stage screening strategy was used to identify DNA-methylation-based signatures for OSCC prognosis. | 28852427 |
| SERPINB3 wt Allele | Epigenetic Alterations | The seven DNA methylation CpG sites were identified which were significantly associated with OSCC overall survival. | 28852427 |
| SERPINB3 wt Allele | Epigenetic Alterations | Prognostic signature integrated of DNA methylation, gene expression, and clinical information provides a better prognostic prediction value for OSCC patients than that with clinical information only. | 28852427 |
| Axis, Primary malignant neoplasm | Epigenetic Alterations | Long Noncoding RNA FAL1 Promotes Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through the PTEN/AKT Signaling Axis in Non-Small Cell Lung Cancer. | 28854421 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, long non-coding RNAs (lncRNAs) have been found to have many biological effects in different cancer stages. | 28854421 |
| Carcinogenesis | Epigenetic Alterations | Global DNA methylation may affect chromosome structure and genomic stability and is involved in carcinogenesis. | 28854562 |
| Arteriosclerosis | Epigenetic Alterations | Little is known regarding the epigenetic basis of atherosclerosis. | 28855511 |
| Liver carcinoma | Epigenetic Alterations | Serum long noncoding RNA urothelial carcinoma-associated 1: A novel biomarker for diagnosis and prognosis of hepatocellular carcinoma. | 28856933 |
| Primary malignant neoplasm | Epigenetic Alterations | Objective Long noncoding RNAs (lncRNAs) offer great potential as cancer biomarkers. | 28856933 |
| Chronic Kidney Diseases | Epigenetic Alterations | Identification of miR-16 as an endogenous reference gene for the normalization of urinary exosomal miRNA expression data from CKD patients. | 28859135 |
| Amyotrophic Lateral Sclerosis | Epigenetic Alterations | Increase in DNA methylation in patients with amyotrophic lateral sclerosis carriers of not fully penetrant SOD1 mutations. | 28859526 |
| Antilymphocyte Serum | Epigenetic Alterations | Global DNA methylation levels were significantly higher in blood DNA of ALS patients than in asymptomatic/paucisymptomatic carriers or family members non-carriers of SOD1 mutations, and a positive correlation between global DNA methylation levels and disease duration (months) was observed. | 28859526 |
| Antilymphocyte Serum | Epigenetic Alterations | The present study suggests that global changes in DNA methylation might contribute to the ALS phenotype in carriers of not fully penetrant SOD1 mutations, thus reinforcing the role of epigenetic factors in modulating the phenotypic expression of the disease. | 28859526 |
| Antilymphocyte Serum | Epigenetic Alterations | We collected DNA samples from five ALS families with not fully penetrant SOD1 mutations (p.Asn65Ser, p.Gly72Ser, p.Gly93Asp, and p.Gly130_Glu133del) searching for epigenetic differences among ALS patients, asymptomatic/paucisymptomatic carriers and non-carrier family members. | 28859526 |
| Carcinoma of lung | Epigenetic Alterations | miR-493 is silenced in resistant lung cancer cell due to the aberrant DNA methylation. | 28859669 |
| Carcinoma of lung, Primary malignant neoplasm | Epigenetic Alterations | Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1). | 28859669 |
| Primary malignant neoplasm | Epigenetic Alterations | The potential mechanisms regarding how methylation of microRNA(miRNA) CpG Island could regulate cancer cell chemo-resistance remains unclear. | 28859669 |
| SF3B1 wt Allele | Epigenetic Alterations | To date, most of the previous studies of miR-124 in MDS have focused on epigenetic changes and little is known about the underlying mechanism through which miR-124 regulates CDK6 expression. | 28861128 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding. | 28863773 |
| Neoplasms | Epigenetic Alterations | Both miRNA-148a and miRNA-625-3p were down-regulated in the tumors compared to normal colonic mucosa. | 28863773 |
| Neoplasms | Epigenetic Alterations | Significantly lower expression of both miRNAs was noticed in tumors with budding phenomenon compared to tumors without it (median values of miRNA-148a were 0.314 and 0.753 respectively, p = 0.011, and 0.404 and 0.620 respectively for miRNA-625-3p, p = 0.036). | 28863773 |
| Neoplasms | Epigenetic Alterations | Significantly lower expression of miRNA-625-3p was detected in rectal tumors, compared to tumors in the colon (median 0.390 and 0.665 respectively, p = 0.037). | 28863773 |
| Neoplasms | Epigenetic Alterations | There was a significant relationship between low miRNA-148a and miRNA-625-3p expression and tumor budding, which is thought to represent epithelial-mesenchymal transition. | 28863773 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes. | 28863773 |
| Clinical Coordinator | Epigenetic Alterations | Both studied miRNAs may be associated with a more aggressive phenotype and could be the potential prognostic and predictive biomarkers in CRC. | 28863773 |
| Hollings Cancer Center | Epigenetic Alterations | We analyzed GPR155 expression, DNA methylation, and copy number in HCC cell lines. | 28863781 |
| Hollings Cancer Center | Epigenetic Alterations | No DNA methylation was detected, whereas copy number alterations were present in five (56%) HCC cell lines. | 28863781 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Dysregulation of microRNAs (miRNAs) has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), which is largely attributable to cigarette smoke (CS). | 28864214 |
| Breast Carcinoma | Epigenetic Alterations | Here we applied bisulfite sequencing to global mitochondrial DNA and whole genomic DNA methylation array from fifteen members of five three-female-generation families with one breast cancer patient in each family. | 28865962 |
| Glioblastoma Multiforme | Epigenetic Alterations | A 4-miRNAs signature predicts survival in glioblastoma multiforme patients. | 28869437 |
| Lymphohistiocytosis, Hemophagocytic | Epigenetic Alterations | In addition, we found out that the mean level of miR-133 (microRNA-133) was significant higher in LAHS than in benign disease associated HLH (18.83 +- 10.44 vs 5.82 +- 3.26, P 0.0001). | 28869447 |
| Breast Carcinoma | Epigenetic Alterations | Large intergenic non-coding RNA-ROR as a potential biomarker for the diagnosis and dynamic monitoring of breast cancer. | 28869448 |
| Peripheral Nervous System Diseases | Epigenetic Alterations | Aberrant microRNA expression in patients with painful peripheral neuropathies. | 28870579 |
| Peripheral Nervous System Diseases | Epigenetic Alterations | Thus, peripheral neuropathies are associated with aberrant miRNA expression in white blood cells, sural nerve, and skin. | 28870579 |
| Peripheral Nervous System Diseases | Epigenetic Alterations | These miRNA patterns may help to identify factors that determine the painfulness of peripheral neuropathies and lead to druggable targets. | 28870579 |
| Muscular Atrophy | Epigenetic Alterations | The course of the disease might reflect differential degree of muscle atrophy and signaling at miRNA levels. | 28870590 |
| Antilymphocyte Serum | Epigenetic Alterations | A significant over-expression of all miRNAs was observed in ALS patients versus controls, in male patients versus females, in patients with early onset versus patients with late onset, and in patients with long disease duration versus patients with short duration. | 28870590 |
| Malignant Pleural Mesothelioma, Neoplasms | Epigenetic Alterations | TargomiRs are minicells (EnGeneIC Dream Vectors) loaded with miR-16-based mimic microRNA (miRNA) and targeted to EGFR that are designed to counteract the loss of the miR-15 and miR-16 family miRNAs, which is associated with unsuppressed tumour growth in preclinical models of malignant pleural mesothelioma. | 28870611 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation of leukocyte DNA has been proposed to be a biomarker for cancer that can be used to target patients for appropriate clinical implementation. | 28871451 |
| Forecast of outcome, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | A Novel Long Non-Coding RNA, SOX21-AS1, Indicates a Poor Prognosis and Promotes Lung Adenocarcinoma Proliferation. | 28873379 |
| Primary malignant neoplasm | Epigenetic Alterations | In recent years, long non-coding RNAs (lncRNAs) have been shown to be a novel class of regulators of cancer biological processes. | 28873379 |
| melanoma | Epigenetic Alterations | IRF6 is aberrantly silenced by DNA methylation of the 5 IRF6 CGI in melanoma. | 28877249 |
| Primary malignant neoplasm | Epigenetic Alterations | Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection. | 28877936 |
| Carcinoma of lung | Epigenetic Alterations | Using epithelial brushings from the mainstem bronchus of patients undergoing bronchoscopy for suspected lung cancer (as part of the AEGIS-1/2 clinical trials), we profiled miRNA expression via small-RNA sequencing from 347 current and former smokers for which gene expression data were also available. | 28877936 |
| Airway structure | Epigenetic Alterations | Following removal of 6 low-quality samples, we used 138 patients (AEGIS-1) as a discovery set to identify four miRNAs (miR-146a-5p, miR-324-5p, miR-223-3p, and miR-223-5p) that were downregulated in the bronchial airway of lung cancer patients (ANOVA P < 0.002, FDR < 0.2). | 28877936 |
| Carcinoma of lung | Epigenetic Alterations | Our findings suggest that there are miRNAs whose expression is altered in the cytologically normal bronchial epithelium of smokers with lung cancer, and that they may regulate cancer-associated gene expression differences. | 28877936 |
| Malignant tumor of colon | Epigenetic Alterations | Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients. | 28878843 |
| Stomach Carcinoma | Epigenetic Alterations | miRNA-4317 suppresses human gastric cancer cell proliferation by targeting ZNF322. | 28880489 |
| Triple-Negative Breast Cancer Finding | Epigenetic Alterations | Prognostic value of microRNA-9 and microRNA-155 expression in triple-negative breast cancer. | 28882698 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) are involved in regulation of epithelial-mesenchymal transition (EMT) during breast cancer progression. | 28882698 |
| Neoplasms | Epigenetic Alterations | MicroRNA exerts a vital function in promoting or inhibiting tumor development. | 28884131 |
| Hollings Cancer Center, Metastasis, Liver carcinoma, Neoplasms | Epigenetic Alterations | The downregulation of microRNA-122 (miR-122) had been reported to be associated with tumor invasion and metastasis in hepatocellular carcinoma (HCC). | 28890291 |
| Ischemic stroke | Epigenetic Alterations | Circulating microRNAs (miRNAs) have been reported as diagnosis biomarkers and predictors in acute ischemic stroke (AIS). | 28892656 |
| Subarachnoid Hemorrhage, Aneurysmal | Epigenetic Alterations | Altered Expression of MicroRNA-15a and Kruppel-Like Factor 4 in Cerebrospinal Fluid and Plasma After Aneurysmal Subarachnoid Hemorrhage. | 28893694 |
| S-Adenosylhomocysteine | Epigenetic Alterations | However, little is known about the role of microRNAs (miRNAs) in the phenotypic alteration after SAH. | 28893694 |
| S-Adenosylhomocysteine | Epigenetic Alterations | Microarray analysis showed that 12 miRNAs including miR-15a were upregulated or downregulated both in the CSF and in plasma after SAH within 3 days. | 28893694 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | There are important epigenetic differences between EBV-negative and EBV-positive NPCs, with EBV-negative NPC having a more similar hypermethylation profile to other head and neck squamous cell carcinomas than EBV-positive NPC. | 28893862 |
| Communicable Diseases | Epigenetic Alterations | After adjusting for potential covariates in linear regression models, we found that HP infection, infection with virulent HP strains (CagA+) and severe CAG were significantly associated with an increase in DNA methylation age by ~0.4, 0.6 and 1 year (all P-values <0.05), respectively. | 28898235 |
| Infection caused by Helicobacter pylori, Gastritis, Atrophic | Epigenetic Alterations | Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults. | 28898235 |
| Carcinoma of lung | Epigenetic Alterations | Thus, epigenetic abnormalities may prime for changing oncogene senescence to addiction for a single key oncogene involved in lung cancer initiation. | 28898697 |
| ovarian neoplasm, Metastasis | Epigenetic Alterations | MicroRNA-30c inhibits metastasis of ovarian cancer by targeting metastasis-associated gene 1. | 28901313 |
| Primary malignant neoplasm | Epigenetic Alterations | The involvement of passenger strands of miRNAs in cancer pathogenesis is a novel concept in miRNA research. | 28902136 |
| Primary malignant neoplasm | Epigenetic Alterations | The ectopic expression of these miRNAs significantly inhibited cancer cell migration and invasion in ccRCC cells. | 28902136 |
| Supraspinatus tear | Epigenetic Alterations | Dysregulated expression and DNA methylation of MMP and TIMP genes were found across the rotator cuff tendon samples of patients with supraspinatus tears. | 28902861 |
| Tears body substance | Epigenetic Alterations | Epigenetic regulation of metalloproteinases and their inhibitors in rotator cuff tears. | 28902861 |
| Tears body substance | Epigenetic Alterations | In conclusion, MMPs and their inhibitors are regulated by epigenetic modifications and may play a role in rotator cuff tears. | 28902861 |
| Primary malignant neoplasm | Epigenetic Alterations | The key mechanisms for this miRNA may be hsa-miR-3148-AR-pathways in cancer or hsa-miR-3148-PRKCA-pathways in cancer/glioma/ErbB signaling pathway. | 28904974 |
| Primary malignant neoplasm, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Among the downregulated miRNAs, MiR-3148 regulated the most target genes and was significantly enriched in pathways in cancer, glioma, and ErbB signaling pathway. | 28904974 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Furthermore, our data revealed that SSTR1/sst1 expression might be regulated by specific miRNAs in PCa, including miR-24, which is downregulated in PCa samples and correlates inversely with SSTR1 expression. | 28905400 |
| Division of Lung Diseases, Lung diseases | Epigenetic Alterations | The significant Ago2-IP enrichment of targets of these miRNAs related to the TGF-b and/or Wnt pathways (NGF, DLD, HHEX) in TGF-b1-stimulated fibroblasts suggest a role for these miRNAs in lung diseases by affecting lung fibroblast function. | 28910321 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The prediction analyses of target genes and integrative analysis of mRNA and miRNA expression revealed eleven genes and eight miRNAs which were validated by RT-qPCR in plasma samples from 102 untreated PCa patients and 50 cancer-free individuals. | 28910345 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | The combination of circulating mRNA and miRNA was useful for the diagnosis and prognosis of PCa. | 28910345 |
| Prostate Cancer Pathway | Epigenetic Alterations | Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer. | 28910345 |
| Neoplasms | Epigenetic Alterations | A total of 2,267 genes and 49 miRNAs were differentially expressed between normal and tumor samples. | 28910345 |
| CHOANAL ATRESIA, POSTERIOR | Epigenetic Alterations | Two genes, OR51E2 and SIM2, and two miRNAs, miR-200c and miR-200b, showed significant association with PCa. | 28910345 |
| Hepatitis B | Epigenetic Alterations | Expression Profiling of Cellular MicroRNA in Asymptomatic HBsAg Carriers and Chronic Hepatitis B Patients. | 28913356 |
| Injury of liver, Hepatitis B, Complete atrioventricular block | Epigenetic Alterations | MicroRNAs (miRNAs) may serve as potential molecular markers to predict liver injury resulting from chronic hepatitis B (CHB). | 28913356 |
| Complete atrioventricular block | Epigenetic Alterations | We identified 79 and 203 differentially expressed miRNAs in the peripheral blood mononuclear cells of ASCs and CHB patients compared to HCs, respectively. | 28913356 |
| Complete atrioventricular block | Epigenetic Alterations | Some of these miRNAs were common to ASCs and CHB patients, but another set of miRNAs that showed differential expression between ASCs and CHB patients was also identified. | 28913356 |
| Arthritis, Gouty | Epigenetic Alterations | MicroRNA-488 and -920 regulate the production of proinflammatory cytokines in acute gouty arthritis. | 28915828 |
| Fibrosis Assessment | Epigenetic Alterations | BET-bromodomain inhibitors modulate epigenetic patterns at the diacylglycerol kinase alpha enhancer associated with radiation-induced fibrosis. | 28916223 |
| Fibrosis Assessment | Epigenetic Alterations | We have previously identified altered epigenetic patterns at a gene enhancer of the diacylglycerol kinase alpha (DGKA) locus in normal skin fibroblasts derived from fibrosis patients. | 28916223 |
| Fibrosis Assessment | Epigenetic Alterations | Interference with epigenetic patterns of fibrosis predisposition may provide novel preventive therapies that improve radiotherapy. | 28916223 |
| Cardiovascular Diseases | Epigenetic Alterations | We found changes in miRNAs and other ex-RNAs with exercise (e.g., Y RNAs and tRNAs) implicated in cardiovascular disease. | 28916639 |
| Perceived stress scale | Epigenetic Alterations | A major difference in miRNA expression patterns was observed between the lymphocyte populations from patients with pSS and controls. | 28916716 |
| Sjogrens Syndrome", Autoimmune Diseases, Perceived stress scale | Epigenetic Alterations | MicroRNAs (miRNAs) play an important role in the pathogenesis of autoimmune diseases such as primary Sjogrens syndrome (pSS). | 28916716 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Micro-RNA Profiling of Exosomes from Marrow-Derived Mesenchymal Stromal Cells in Patients with Acute Myeloid Leukemia: Implications in Leukemogenesis. | 28918518 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | Gene regulatory networks in AML may be influenced by microRNAs (miRs) contained in exosomes derived from bone marrow mesenchymal stromal cells (MSCs). | 28918518 |
| Neoplasms | Epigenetic Alterations | Tumor and serum DNA methylation in women receiving preoperative chemotherapy with or without vorinostat in TBCRC008. | 28918548 |
| Degenerative polyarthritis | Epigenetic Alterations | MicroRNA-218-5p as a Potential Target for the Treatment of Human Osteoarthritis. | 28919376 |
| Degenerative polyarthritis | Epigenetic Alterations | Emerging evidence suggests that dysregulated microRNAs (miRNAs) play a pivotal role in osteoarthritis (OA), but the role of specific miRNAs remains unclear. | 28919376 |
| Aneurysm | Epigenetic Alterations | Alginate oligosaccharide indirectly affects toll-like receptor signaling via the inhibition of microRNA-29b in aneurysm patients after endovascular aortic repair. | 28919708 |
| Stomach Carcinoma | Epigenetic Alterations | Association of microRNA Polymorphisms with the Risk of Gastric Cancer in a Romanian Population. | 28922434 |
| Malignant Neoplasms, Stomach Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) play an important role in the occurrence and progression of human cancers, including gastric cancer. | 28922434 |
| Primary malignant neoplasm | Epigenetic Alterations | Given their prevalence in the human genome, close correlation with gene expression and high chemical stability, these DNA epigenetic marks could serve as ideal biomarkers for cancer diagnosis. | 28925386 |
| Squamous cell carcinoma | Epigenetic Alterations | We hypothesized that transformation of normal epidermis to cutaneous squamous cell carcinoma (cSCC) is causally linked to alterations in microRNAs (miRNA) expression. | 28925390 |
| Squamous cell carcinoma | Epigenetic Alterations | Alterations of microRNAs throughout the malignant evolution of cutaneous squamous cell carcinoma: the role of miR-497 in epithelial to mesenchymal transition of keratinocytes. | 28925390 |
| Malignant Neoplasms, Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Down-regulation of long non-coding RNA tumor suppressor candidate 7(TUSC7) contributes to tumorigenesis in several human cancers including glioma. | 28925483 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | We have identified a DNA methylation profile regulating key cellular processes in CRC, resulting in a growth advantage to the tumor cells. | 28931069 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Genetic and epigenetic alterations mark colorectal cancer (CRC). | 28931069 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs (miRNAs) are short noncoding RNAs that play critical roles in human malignancies and can be used as biomarkers for cancer. | 28931080 |
| Stomach Carcinoma | Epigenetic Alterations | Long noncoding RNA (lncRNA) phosphatase and tensin homolog pseudogene 1 (PTENP1) is significantly downregulated in gastric cancer (GC), playing critical roles in GC progression. | 28931965 |
| Secondary malignant neoplasm of rectum | Epigenetic Alterations | MicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor. | 28932920 |
| Clinical Coordinator, Metastasis | Epigenetic Alterations | miR-30a functions as a tumor-suppressive miRNA, which may provide a therapeutic strategy for metastasis of CRC. | 28932920 |
| Neurodevelopmental Disorders, Syndrome | Epigenetic Alterations | An ever-increasing group of neurodevelopmental disorders due to derangements of epigenetic regulation involve both microdeletion and monogenic syndromes. | 28933030 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Long non-coding RNA SNHG17 is an unfavourable prognostic factor and promotes cell proliferation by epigenetically silencing P57 in colorectal cancer. | 28933484 |
| Malignant Neoplasms, Colorectal Cancer Pathway, Clinical Coordinator | Epigenetic Alterations | Recently, substantial evidence has demonstrated that long non-coding RNAs (lncRNAs) play critical roles in multiple cancers including colorectal cancer (CRC). | 28933484 |
| Inflammation | Epigenetic Alterations | We hypothesize that differential systemic levels of miRNA expression reflect miRNA dysregulation at sites of spinal inflammation or bone formation where these molecules contribute to the development of pathophysiological features typical of AxSpA. | 28938006 |
| Axial spondyloarthritis | Epigenetic Alterations | Association between circulating miRNAs and spinal involvement in patients with axial spondyloarthritis. | 28938006 |
| Autoimmune Diseases | Epigenetic Alterations | Dysregulation of miRNAs and their target genes contributes to the pathophysiology of autoimmune diseases. | 28938006 |
| Malignant neoplasm of mouth | Epigenetic Alterations | Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer. | 28939082 |
| SERPINB3 wt Allele | Epigenetic Alterations | Moreover, epigenetic therapy could be a promising strategy for the treatment of OSCC. | 28939082 |
| Lichen Planus | Epigenetic Alterations | MicroRNAs in cutaneous lichen planus. | 28940245 |
| Inflammatory dermatosis | Epigenetic Alterations | MicroRNAs (miRNAs) are short RNAs encoded in both protein coding and noncoding areas of the genome, and have been found to be involved in the pathogenesis of some inflammatory skin diseases. | 28940245 |
| Malignant Neoplasms | Epigenetic Alterations | DNA methylation in specific genomic regions, which had shown strongly association with disease genotypes, was an effective indicator to reveal the occurrence and development of cancers. | 28940471 |
| Clinical Coordinator | Epigenetic Alterations | These findings supported CNRIP1 and RUNX3 as potential DNA methylation biomarkers for CRC diagnosis and treatment, and our LC-MS/MS approach exhibited great advantages in the identification of regional DNA methylation biomarkers. | 28940471 |
| Pancreatic carcinoma, Metastasis | Epigenetic Alterations | Long non-coding RNA CRNDE sponges miR-384 to promote proliferation and metastasis of pancreatic cancer cells through upregulating IRS1. | 28940804 |
| Malignant Neoplasms, Colorectal Neoplasms | Epigenetic Alterations | Colorectal neoplasia differentially expressed (CRNDE), a vital cancer-related long non-coding RNA (lncRNA), has been brought to reports for playing quintessential functions in the growth and progression of several human malignancies. | 28940804 |
| Primary malignant neoplasm | Epigenetic Alterations | Ultraconserved elements (UCEs) encoding noncoding RNAs serve as important regulators in cancer biology. | 28941722 |
| Malignant tumor of colon | Epigenetic Alterations | Long non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as a competing endogenous RNA. | 28943452 |
| Multiple Pregnancy | Epigenetic Alterations | In recent years, accumulating evidence indicates that long noncoding RNAs (lncRNAs) have emerged as powerful influence factors in the progression of multiple malignancies. | 28943452 |
| Malignant tumor of colon, Metastasis | Epigenetic Alterations | Moreover, HNF1A-AS1 functioned as an oncogene in metastasis of colon cancer in part through serving as a competing endogenous RNA to modulate miRNA-34a expression, subsequently with repression of miR-34a/SIRT1/p53 feedback loop and activation of canonical Wnt signaling pathway. | 28943452 |
| Neoplasms | Epigenetic Alterations | The data on positive correlation between the expression of microRNA-21 and microRNA-221 and negative receptor status of the tumor were confirmed. | 28944429 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | The expression of the tumor suppressing microRNA-125b decreased in samples of breast cancer expressing HER2 and ER and in triple negative breast cancer, which characterizes it as a universal marker of breast cancer. | 28944429 |
| Breast Carcinoma | Epigenetic Alterations | An increase in the expression of microRNA-16 was shown in samples of breast cancer expressing HER2 and ER. | 28944429 |
| Breast Carcinoma | Epigenetic Alterations | The expression of microRNA-17 decreased in triple negative breast cancer and increased in ER+, PR+, and HER+ types of breast cancer. | 28944429 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Search of MicroRNAs Regulating the Receptor Status of Breast Cancer In Silico and Experimental Confirmation of Their Expression in Tumors. | 28944429 |
| Breast Carcinoma | Epigenetic Alterations | The expression of 9 microRNAs (16, 17, 21, 27, 125, 146, 155, 200a, and 221) was analyzed in 76 samples of breast cancer with various receptor phenotypes. | 28944429 |
| Breast Carcinoma | Epigenetic Alterations | The expression of microRNAs 155, 27, and 200a did not differ in various types of breast cancer. | 28944429 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNAs 16, 17, 21, 125b, 146b, and 221 can be promising markers for differential diagnostics of various phenotypes of breast cancer. | 28944429 |
| Secondary malignant neoplasm of liver, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA (miR)-200 and miR-141 have been confirmed to be aberrantly expressed in colorectal cancer, however, whether miR-200 and miR-141 are involved in the progression of colorectal cancer, and their role in liver metastasis remain to be fully elucidated. | 28944840 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | A total of 37 mRNAs and 10 miRNAs were identified, which were closely associated with the survival rates of patients with grade III glioma. | 28944855 |
| Trauma Symptom Checklist for Children Questionnaire, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Previous studies have demonstrated that aberrantly expressed cancer-associated microRNAs (miRs) may be associated with tumorigenesis and tumor development in various types of cancer, including TSCC. | 28944863 |
| Heart failure, Cardiac fibrosis, Hypertrophy | Epigenetic Alterations | microRNA 21 (miRNA-21) promotes the development of cardiac fibrosis, hypertrophy and heart failure. | 28944900 |
| Heart failure | Epigenetic Alterations | Circulating miRNA-21 is a promising biomarker for heart failure. | 28944900 |
| Heart failure | Epigenetic Alterations | Follow-up of the patients with heart failure indicated that miRNA-21-PV and miRNA-21-CS were correlated with prognosis, and miRNA-21-CS was efficient in predicting re-hospitalization for heart failure. | 28944900 |
| Heart failure | Epigenetic Alterations | Circulating miRNA-21 has potential to be a biomarker of heart failure. | 28944900 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-340 inhibits tumor cell proliferation, migration and invasion, and induces apoptosis in hepatocellular carcinoma. | 28944918 |
| Liver carcinoma, Hollings Cancer Center | Epigenetic Alterations | MicroRNAs (miRs) are short RNAs that serve a role in the origination and progression of hepatocellular carcinoma (HCC). | 28944918 |
| Malignant neoplasm of urinary bladder | Epigenetic Alterations | Long non-coding RNA HULC promotes bladder cancer cells proliferation but inhibits apoptosis via regulation of ZIC2 and PI3K/AKT signaling pathway. | 28946549 |
| Glioblastoma Multiforme | Epigenetic Alterations | Reduced circulating microRNA-203 predicts poor prognosis for glioblastoma. | 28946553 |
| Primary malignant neoplasm, Glioblastoma Multiforme | Epigenetic Alterations | MicroRNAs (miRNAs) have been demonstrated to play an important role in the development and progression of various types of cancer including glioblastoma (GBM). | 28946553 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) emerge as important regulators involved in malignant progression in some tumors. | 28946554 |
| Malignant Neoplasms, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Blood-circulating miRNAs have been reported to act as potential biomarkers in various cancers including non-small cell lung cancer (NSCLC). | 28946561 |
| Metastasis, Neoplasms | Epigenetic Alterations | Recently, long noncoding RNAs (lncRNAs) have been served as key regulators implicated in tumor development and progression by promoting proliferation, invasion and metastasis. | 28946875 |
| Acute heart failure | Epigenetic Alterations | Serially measured circulating microRNAs and adverse clinical outcomes in patients with acute heart failure. | 28948688 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-21 (Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer. | 28957811 |
| Clinical Coordinator, Carcinogenesis, Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-21 (miR-21) has been demonstrated to play an important role in carcinogenesis; however, its mechanism of action in colorectal cancer (CRC) has not been fully elucidated. | 28957811 |
| Hollings Cancer Center, Neoplasms | Epigenetic Alterations | Down-regulation was observed for 11 miRNAs in HCC indicating their tumour suppression activity. | 28958640 |
| Squamous cell carcinoma, Nasal Cavity and Paranasal Sinus Carcinoma | Epigenetic Alterations | Deregulation of selected microRNAs in sinonasal carcinoma: Value of miR-21 as prognostic biomarker in sinonasal squamous cell carcinoma. | 28960576 |
| Carcinogenesis, Triple-Negative Breast Cancer Finding | Epigenetic Alterations | Long non-coding RNA ANRIL promotes carcinogenesis via sponging miR-199a in triple-negative breast cancer. | 28961506 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | The diagnostic role of plasma circulating precursors of miRNA-944 and miRNA-3662 for non-small cell lung cancer detection. | 28964576 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | To date there is little known about role of miRNA precursors (pri-miRNA) in carcinogenesis and their utility as tumor markers. | 28964576 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | miRNA-944 and miRNA-3662 precursors as potential non-small cell lung cancer (NSCLC) markers were analyzed in plasma samples of 56 patients in an early stage of NSCLC and 100 healthy individuals. | 28964576 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Circulating pri-miRNA-944 and 3662 can improve non-invasive NSCLC detection of operable stages of SCC and AC. | 28964576 |
| Carcinoma of lung | Epigenetic Alterations | miRNA precursors could be considered as novel potential lung cancer biomarkers. | 28964576 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Long noncoding RNA ZEB1-AS1 expression predicts progression and poor prognosis of colorectal cancer. | 28967064 |
| Breast Cancer Cell, Squamous cell carcinoma of esophagus | Epigenetic Alterations | MicroRNAs (miRNAs) play important roles in the progression of human cancer including esophageal squamous cell carcinoma (ESCC). | 28968424 |
| Malignant neoplasm of liver | Epigenetic Alterations | One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation. | 28968444 |
| Primary malignant neoplasm | Epigenetic Alterations | An aberrant DNA methylation is a common feature in cancer but whether the link between one-carbon metabolism variants and cancer occurs through an altered DNA methylation is yet unclear. | 28968444 |
| hearing impairment | Epigenetic Alterations | miRNAs, which play important roles in inner ear development, were detected in all samples, i.e., in both young and old elderly subjects, whether with or without hearing loss. | 28968605 |
| Retinoblastoma, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-675 promotes glioma cell proliferation and motility by negatively regulating retinoblastoma 1. | 28970140 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Previous studies indicated that microRNA (miR)-675 and its precursor lncRNA H19 were both overexpressed in glioma tissues, and H19 might play an oncogenic role. | 28970140 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | In addition, miR-675 may act as an oncogenic miRNA in glioma cells via regulating its target gene RB1. | 28970140 |
| insulinoma | Epigenetic Alterations | Here, we show at the pathway level that the majority of the insulinomas display mutations, copy number variants and/or dysregulation of epigenetic modifying genes, most prominently in the polycomb and trithorax families. | 28974674 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Long non-coding RNA SBDSP1 (SBDSP1) had been reported to be increased in colorectal cancer (CRC), but its effects on prognosis were still unclear. | 28975982 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Long non-coding RNA Loc344887 is a potential prognostic biomarker in non-small cell lung cancer. | 28975987 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Long non-coding RNA NmrA-like family domain containing 1 pseudogene (Loc344887) has been shown to be aberrantly expressed in non-small cell lung cancer (NSCLC). | 28975987 |
| Primary malignant neoplasm | Epigenetic Alterations | H19, a maternally expressed imprinted gene transcribing a long noncoding RNA, has previously been reported to be involved in tumorigenesis and cancer progression. | 28975993 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | BACKGROUND MicroRNAs (miRNAs) play an important role in the development and progression of acute myeloid leukemia (AML). | 28978904 |
| Liver carcinoma | Epigenetic Alterations | Plasma DNA methylation marker and hepatocellular carcinoma risk prediction model for the general population. | 28981677 |
| Prostate Cancer Pathway | Epigenetic Alterations | For this purpose, RNA was extracted from urinary exosomes from 20 prostate cancer patients and 9 healthy males and the microRNAs were analyzed by next generation sequencing. | 28982366 |
| Prostate Cancer Pathway | Epigenetic Alterations | Interestingly, 5 microRNAs - miR-196a-5p, miR-34a-5p, miR-143-3p, miR-501-3p and miR-92a-1-5p - were significantly downregulated in exosomes from prostate cancer patients. | 28982366 |
| Prostate Cancer Pathway | Epigenetic Alterations | These results suggest that specific microRNAs in urinary exosomes might serve as non-invasive biomarkers for prostate cancer. | 28982366 |
| Hollings Cancer Center | Epigenetic Alterations | On the other hand, miR-223 has been identified as one of the most down-regulated miRNAs in HCC, and its expression was shown to be negatively correlated with STMN1 expression. | 28982915 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | CISD2 promotes the proliferation of glioma cells via suppressing beclin-1-mediated autophagy and is targeted by microRNA-449a. | 28983596 |
| Stomach Carcinoma | Epigenetic Alterations | A serum exosomal microRNA panel as a potential biomarker test for gastric cancer. | 28986250 |
| Primary malignant neoplasm | Epigenetic Alterations | Both normal and cancer cells can generate and secrete exosomes, which are nanosized membrane vesicles that can transport microRNAs and proteins. | 28986250 |
| Stomach Carcinoma | Epigenetic Alterations | The findings from several studies have suggested that circulating miRNAs are imbalanced with the genesis of gastric cancer (GC). | 28986250 |
| Hepatobiliary Disorder | Epigenetic Alterations | MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease. | 28987423 |
| Rheumatoid Arthritis | Epigenetic Alterations | MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3. | 28987940 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Rheumatoid arthritis-fibroblast-like synoviocytes (RA-FLS) with aberrant expression of microRNA (miRNA) have been reported to be involved in the initiation, progression, and perpetuation of rheumatoid arthritis (RA). | 28987940 |
| Clinical Coordinator | Epigenetic Alterations | miRNA expression in CRC specimens and cell lines was confirmed using qPCR analysis. | 28990086 |
| Clinical Coordinator | Epigenetic Alterations | RNA-seq data revealed miR-1914 as the most prominent miRNA in CRC specimens. | 28990086 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | MicroRNA-24-2 is associated with cell proliferation, invasion, migration and apoptosis in renal cell carcinoma. | 28990105 |
| Acute pulmonary embolism | Epigenetic Alterations | Diagnostic value of circulating microRNA-27a/b in patients with acute pulmonary embolism. | 28990745 |
| Retinoblastoma | Epigenetic Alterations | Histone H3 lysine-9 (H3K9) methylation is essential for retinoblastoma protein (RB)-mediated heterochromatin formation, epigenetic silencing of S-phase genes and permanent cell cycle arrest or cellular senescence. | 28991226 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Four oncogenic microRNAs (miR-155, miR-19a, miR-181b, and miR-24) and one tumor suppressor microRNA (let-7a) were shown to differentiate between high- and low-risk early breast cancer (EBC) and reflect the surgical tumor removal and adjuvant therapy. | 28994735 |
| Breast Carcinoma, Best Case Imputation Technique | Epigenetic Alterations | Oncogenic microRNAs (oncomiRs) accumulate in serum due to their increased stability and thus serve as biomarkers in breast cancer (BC) pathogenesis. | 28994735 |
| Breast Carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1. | 29016617 |
| Neoplasms | Epigenetic Alterations | In the last years, microRNAs were screened as new tumor markers for their potential diagnostic and therapeutic relevance. | 29017393 |
| Prostate Cancer Pathway, histone modification | Epigenetic Alterations | KLF4-binding and histone-modifications were analyzed by ChIP-qPCR in prostate cancer cell lines exhibiting differentially methylated IGF2-DMR0 (LNCaP hypomethylated and DU145 hypermethylated). | 29017567 |
| Prostate Cancer Pathway | Epigenetic Alterations | Impairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4. | 29017567 |
| Liver carcinoma | Epigenetic Alterations | Hepatocellular carcinoma harbors numerous genomic and epigenomic aberrations of DNA copy numbers and DNA methylation. | 29018224 |
| Liver carcinoma | Epigenetic Alterations | Here, we profile DNA copy numbers, DNA methylation, and messenger RNA expression levels from 64 cases of hepatocellular carcinoma specimens. | 29018224 |
| Malignant Neoplasms | Epigenetic Alterations | There is an increasing body of evidence which highlights the critical functions of long non-coding RNAs in the carcinogenicity mechanism of a variety of cancers. | 29022495 |
| Leukemia, Myelocytic, Acute | Epigenetic Alterations | DNA methyltransferase 3A (DNMT3A) catalyzes de novo DNA methylation and plays important roles in the pathogenesis of acute myeloid leukemia. | 29024628 |
| Primary malignant neoplasm | Epigenetic Alterations | Inhibition of MicroRNA-21-5p Promotes the Radiation Sensitivity of Non-Small Cell Lung Cancer Through HMSH2. | 29024929 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-373 Inhibits Cell Proliferation and Invasion via Targeting BRF2 in Human Non-small Cell Lung Cancer A549 Cell Line. | 29025258 |
| Papillary thyroid carcinoma | Epigenetic Alterations | Roles of microRNA let-7b in papillary thyroid carcinoma by regulating HMGA2. | 29025376 |
| Neoplasms | Epigenetic Alterations | MicroRNAs have been demonstrated to be abnormally expressed in tumors and associated with the development of the tumors. | 29025376 |
| Primary malignant neoplasm | Epigenetic Alterations | Single nucleotide polymorphisms at microRNA-binding sites contribute to cancer susceptibility and progression by affecting the messenger RNA (mRNA) function of target genes. | 29029037 |
| Cardiovascular Diseases | Epigenetic Alterations | Cumulative evidence shows that long noncoding RNAs among noncoding RNAs play important roles in cardiovascular diseases. | 29030044 |
| Acute myocardial infarction | Epigenetic Alterations | Platelet microRNA for predicting acute myocardial infarction. | 29030746 |
| Tongue Diseases | Epigenetic Alterations | Correlation of altered expression of a long non-coding RNA, NEAT1, in peripheral blood mononuclear cells with dengue disease progression. | 29031635 |
| Tongue Diseases | Epigenetic Alterations | The association of long non-coding RNAs (lncRNAs) with dengue disease progression is currently unknown. | 29031635 |
| Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. | 29034803 |
| Malignant Neoplasms | Epigenetic Alterations | Previous studies had demonstrated that ANGPTL4 is highly expressed in some cancers, but downregulated, by DNA methylation, in others. | 29035390 |
| Carcinoma, Transitional Cell, Neoplasms | Epigenetic Alterations | Epigenetic silencing of the dual-role signal mediator, ANGPTL4 in tumor tissues and its overexpression in the urothelial carcinoma microenvironment. | 29035390 |
| Carcinoma, Transitional Cell, Ulcerative Colitis, Carcinogenesis | Epigenetic Alterations | Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). | 29035390 |
| Neoplasms | Epigenetic Alterations | Oncogenic microRNAs (miRs) are stable epigenetic inhibitors often deregulated in the tumour and detectable as biomarkers in non-cellular fractions of peripheral blood. | 29036928 |
| TSPYL2 wt Allele | Epigenetic Alterations | We herein asked whether these microRNAs can be used as plasma biomarkers for clinical CTCL monitoring. | 29036928 |
| Primary malignant neoplasm | Epigenetic Alterations | No DNA methylation could be found in the selected CpG islands in two types of cancer cell lines by bisulfite sequencing. | 29037838 |
| Carcinoma of lung, Colorectal Cancer Pathway | Epigenetic Alterations | Expression and epigenetic regulation of cystatin B in lung cancer and colorectal cancer. | 29037838 |
| ovarian neoplasm | Epigenetic Alterations | MicroRNA-455 inhibits cell proliferation and invasion of epithelial ovarian cancer by directly targeting Notch1. | 29039517 |
| Breast Cancer Cell | Epigenetic Alterations | For instance, microRNA-455 (miR-455) is abnormally expressed in various types of human cancer. | 29039517 |
| Stomach Carcinoma | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) serve important functions in many crucial biological processes; however, the effects of lncRNAs in early gastric cancer (EGC) are not entirely clear. | 29039538 |
| Malignant Neoplasms, Metastasis, Neoplasms | Epigenetic Alterations | A growing body of evidence suggests that microRNA-363 (miR-363) plays crucial roles in tumor progression, development and metastasis, and confer resistance to chemotherapeutic drugs in several types of cancers. | 29039555 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1-mediated PTEN/AKT signalling pathway. | 29039575 |
| Primary malignant neoplasm | Epigenetic Alterations | Dysregulated microRNAs (miRNAs) have potential regulatory roles in the development and progression of various cancer types. | 29039575 |
| Clinical Coordinator | Epigenetic Alterations | Therefore, the investigation of the miRNAs involved in CRC formation and progression may lead to the development of highly effective therapeutic strategies for CRC. | 29039575 |
| Acute myocardial infarction, NCI CTEP SDC Neuroendocrine Cancer Sub-Category Terminology, Chronic Lymphocytic Leukemia | Epigenetic Alterations | Long non-coding RNA MIAT has been established as a key player in the regulation of various biological and pathological processes including chronic lymphocytic leukemias, acute myocardial infarction and neuroendocrine prostate cancer. | 29039602 |
| Neoplasms | Epigenetic Alterations | We conclude that epigenetic downregulation of tumor suppressor KIBRA may involve impaired SP1 binding to functional methylation-sensitive KIBRA promoter elements as observed in human kidney clear cell carcinoma. | 29046731 |
| Neoplasms | Epigenetic Alterations | Using matched gene expression and DNA methylation data in EAC from TCGA and other publically available data, we also find that advanced methylomic drift is correlated with significant transcriptional repression of ~ 200 genes in important regulatory and developmental pathways, including several checkpoint and tumor suppressor-like genes. | 29046735 |
| Barrett Esophagus | Epigenetic Alterations | Identification of a key role of widespread epigenetic drift in Barretts esophagus and esophageal adenocarcinoma. | 29046735 |
| Carcinogenesis | Epigenetic Alterations | However, the evolving patterns, functional consequences, and dynamics of epigenetic drift during carcinogenesis remain largely unexplored. | 29046735 |
| Barrett Esophagus, Adenocarcinoma Of Esophagus, Primary malignant neoplasm | Epigenetic Alterations | Here we analyze the evolution of epigenetic drift patterns during progression from normal squamous esophagus tissue to Barretts esophagus (BE) to esophageal adenocarcinoma (EAC) using 173 tissue samples from 100 (nonfamilial) BE patients, along with publically available datasets including The Cancer Genome Atlas (TCGA). | 29046735 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis. | 29048575 |
| Clinical Coordinator | Epigenetic Alterations | We provide the first evidence that variations in potential miRNA-binding target sites in the 3 UTR of PARP1 gene may modulate CRC risk and prognosis after therapy. | 29048575 |
| Clinical Coordinator | Epigenetic Alterations | Similarly, aberrant function and/or altered expression of microRNAs (miRNAs) often occur in CRC. | 29048575 |
| Malignant Neoplasms, Carcinoma of lung | Epigenetic Alterations | Altered microRNA expression has been found to be a common feature of several cancers, including lung carcinomas. | 29048613 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1. | 29048619 |
| Carcinogenesis, Neoplasms | Epigenetic Alterations | Accumulating evidence has demonstrated that aberrant miRNAs were involved in carcinogenesis and tumor progression by regulating oncogenes or tumor suppressor expression. | 29048619 |
| Clinical Coordinator, Neoplasms | Epigenetic Alterations | Tumour progression and development in CRC is a multi-step process involving a large number of genetic and epigenetic alterations. | 29048669 |
| Colorectal Cancer Pathway | Epigenetic Alterations | MicroRNA-337 inhibits colorectal cancer progression by directly targeting KRAS and suppressing the AKT and ERK pathways. | 29048669 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA-337 (miR-337) has been reported to be downregulated in several cancer types. | 29048669 |
| Clinical Coordinator | Epigenetic Alterations | Previous studies indicated that abnormally expressed microRNAs play critical roles in CRC through regulation of oncogenic and tumour-suppressor genes. | 29048669 |
| Clinical Coordinator | Epigenetic Alterations | Hence, determination of the function of microRNAs may provide novel therapeutic targets for CRC diagnosis and treatments. | 29048669 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1. | 29048674 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNAs (miRNAs) are a group of critical players in gastric cancer (GC). | 29048674 |
| Malignant neoplasm of urinary bladder, Malignant Neoplasms | Epigenetic Alterations | MicroRNA-154 as a prognostic factor in bladder cancer inhibits cellular malignancy by targeting RSF1 and RUNX2. | 29048677 |
| Breast Cancer Cell, Metastasis | Epigenetic Alterations | Recent studies have demonstrated that microRNA-154 (miR-154) is involved in tumorigenesis, progression, invasion and metastasis in several types of human cancer. | 29048677 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Long non-coding RNA PAR5 inhibits the proliferation and progression of glioma through interaction with EZH2. | 29048683 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Emerging evidence suggests that long non-coding RNAs (lncRNAs) may be involved in modulating various aspects of tumor biology and serve as potential therapeutic targets as well as novel biomarkers in the treatment of glioma. | 29048683 |
| Weight decreased | Epigenetic Alterations | We also generated a potential epigenetic predictor of weight loss using baseline DNA methylation at 5 CpG sites. | 29049890 |
| Autoimmune state | Epigenetic Alterations | The potential future use of L1 ORF2-reverse transcriptase inhibitors in autoimmunity supports further investigation of L1 epigenetic regulation by APOBEC3 enzymes. | 29057505 |
| Gallbladder Carcinoma, Metastasis | Epigenetic Alterations | Prognostic significance of long non-coding RNA MALAT1 for predicting the recurrence and metastasis of gallbladder cancer and its effect on cell proliferation, migration, invasion, and apoptosis. | 29058818 |
| Stomach Carcinoma | Epigenetic Alterations | Numerous studies have proved that microRNAs (miRNAs) play crucial roles in the tumorigenesis and progression of gastric cancer (GC). | 29060930 |
| Metastasis, Liver carcinoma | Epigenetic Alterations | MicroRNA-30a suppresses autophagy-mediated anoikis resistance and metastasis in hepatocellular carcinoma. | 29061507 |
| Liver carcinoma | Epigenetic Alterations | MiRNA-30a (miR-30a) was previously reported as one of metastatic hepatocellular carcinoma (HCC)-related microRNAs. | 29061507 |
| Cardiac complication | Epigenetic Alterations | MicroRNA 499 gene expression in patients on hemodialysis with cardiovascular complications. | 29064177 |
| Kidney Failure, Chronic, Cardiac complication | Epigenetic Alterations | In conclusion, miRNA 499 levels are elevated in patients with ESRD with cardiovascular complications. | 29064177 |
| Secondary malignant neoplasm of liver, Neoplasms | Epigenetic Alterations | Combinatory target prediction identified tenascin C as a predicted target of miR-198, one of the top 10 miRNAs downregulated in tumour stroma of CRCs with synchronous liver metastasis. | 29065427 |
| Clinical Coordinator, Secondary malignant neoplasm of liver | Epigenetic Alterations | Alterations of miRNAs in CRC stroma appear to form a metastasis-permissive environment that can elevate tenascin C to promote liver metastasis. | 29065427 |
| Colorectal Cancer Pathway, Neoplasms | Epigenetic Alterations | MicroRNA-329 serves a tumor suppressive role in colorectal cancer by directly targeting transforming growth factor beta-1. | 29067459 |
| Clinical Coordinator, Primary malignant neoplasm | Epigenetic Alterations | Increasing studies have demonstrated that the deregulation of microRNAs (miRNAs or miRs) is associated with the occurrence and development of multiple types of human cancer, including CRC. | 29067459 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | We examined how dysregulated gene expression is associated with miRNA expression in this pathway in colorectal cancer (CRC). | 29068474 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The PI3K/AKT signaling pathway: Associations of miRNAs with dysregulated gene expression in colorectal cancer. | 29068474 |
| Left Ventricular Hypertrophy, Hypertensive (finding) | Epigenetic Alterations | MicroRNA profiling identifies miR-7-5p and miR-26b-5p as differentially expressed in hypertensive patients with left ventricular hypertrophy. | 29069223 |
| Left Ventricular Hypertrophy, Hypertensive disease | Epigenetic Alterations | We employed miRNA PCR array to screen serum miRNAs profiles of patients with LVH, essential hypertension and healthy subjects. | 29069223 |
| Cardiovascular Diseases | Epigenetic Alterations | Recent evidence suggests that cell-derived circulating miRNAs may serve as biomarkers of cardiovascular diseases. | 29069223 |
| Left Ventricular Hypertrophy | Epigenetic Alterations | We identified 75 differentially expressed miRNAs, including 49 upregulated miRNAs and 26 downregulated miRNAs between LVH and control patients. | 29069223 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | MicroRNA-30a-5p Inhibits the Growth of Renal Cell Carcinoma by Modulating GRP78 Expression. | 29073630 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | MiR-30a-5p, a member of the microRNA-30 family (miR-30), is known to function as a tumor suppressor in several different cancers. | 29073630 |
| Malignant Neoplasms | Epigenetic Alterations | Exosomal miRNAs that play an important role in cell-cell communication have attracted major attention as potential diagnostic and prognostic biomarkers for various cancers. | 29076027 |
| cervical cancer | Epigenetic Alterations | Regulation of miRNA gene expression by DNA promoter methylation may represent a key mechanism to drive cervical cancer progression. | 29077234 |
| Carcinogenesis | Epigenetic Alterations | Taken together, we have identified deregulation of miRNAs by aberrant DNA promoter methylation, leading to its transcriptional silencing during cervical carcinogenesis, which can be potential targets for diagnosis and therapy. | 29077234 |
| Primary malignant neoplasm | Epigenetic Alterations | Dysregulated miRNA-223 expression has been implicated in a wide range of cancer subtypes. | 29079174 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Circulating long non-coding RNA AFAP1-AS1 is a potential diagnostic biomarker for non-small cell lung cancer. | 29080690 |
| Clinical Coordinator | Epigenetic Alterations | Recently, data supported that DNA methylation have a role in CRC pathogenesis. | 29080834 |
| Stomach Carcinoma, Metastasis | Epigenetic Alterations | Enhanced expression of the long non-coding RNA SNHG16 contributes to gastric cancer progression and metastasis. | 29081409 |
| Laryngeal Squamous Cell Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Altered microRNAs (miRNAs) expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC). | 29082244 |
| Impaired cognition | Epigenetic Alterations | Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. | 29084334 |
| Impaired cognition | Epigenetic Alterations | Brain gene expression and DNA methylation dysregulations are implicated in the alteration of brain tissue properties associated with late-life cognitive decline above and beyond the influence of common neuropathologic conditions. | 29084334 |
| Colorectal Cancer Pathway | Epigenetic Alterations | microRNAs are small non-protein-coding RNA molecules that regulate gene expression, and have a potential epigenetic role in disease progression and survival of colorectal cancer. | 29084506 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Identifying factors associated with the direction and significance of microRNA tumor-normal expression differences in colorectal cancer. | 29084506 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Our results will serve as a publicly-available resource to provide clarifying information about various factors associated with the direction and significance of tumor-normal differential expression of microRNAs in colorectal cancer. | 29084506 |
| ovarian neoplasm | Epigenetic Alterations | Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer. | 29087294 |
| ovarian neoplasm | Epigenetic Alterations | Among 454 patients with various diagnoses, the miRNA neural network had 100% specificity for ovarian cancer. | 29087294 |
| ovarian neoplasm | Epigenetic Alterations | These data suggest circulating miRNAs have potential to develop a non-invasive diagnostic test for ovarian cancer. | 29087294 |
| Malignant Neoplasms | Epigenetic Alterations | Subunits of the SWI/SNF chromatin remodeling complex are frequently mutated in human cancers leading to epigenetic dependencies that are therapeutically targetable. | 29087303 |
| AMD1 wt Allele | Epigenetic Alterations | However, the role of long noncoding RNAs (lncRNAs) in the development and progression of early AMD is unclear. | 29089757 |
| Breast Carcinoma, Carcinogenesis, Metastasis | Epigenetic Alterations | Previous studies have indicated that large intergenic non-coding RNA regulator of reprogramming (lincRNA-ROR) plays an important role in regulating tumor carcinogenesis and metastasis; however, whether circulating lincRNA-ROR could function as a potential biomarker for breast cancer (BC) diagnosis and monitoring is unknown. | 29090518 |
| Stomach Carcinoma, EIF5A2 gene, Metastasis | Epigenetic Alterations | MicroRNA-599 inhibits metastasis and epithelial-mesenchymal transition via targeting EIF5A2 in gastric cancer. | 29091897 |
| Stomach Carcinoma | Epigenetic Alterations | The reliable truth that exceptional miRNAs contribute to gastric cancer (GC) development and progression had been testified by researchers. | 29091897 |
| cervical cancer | Epigenetic Alterations | MicroRNA-150 promotes cell proliferation, migration, and invasion of cervical cancer through targeting PDCD4. | 29091902 |
| Clinical Coordinator | Epigenetic Alterations | CRC develops through combinations of genetic and epigenetic changes. | 29094309 |
| Chronic Kidney Diseases, Fibrosis Assessment | Epigenetic Alterations | Of 19 CpG sites significantly associated (P < 1e-07) with eGFR/CKD and replicated, five also associate with renal fibrosis in biopsies from CKD patients and show concordant DNA methylation changes in kidney cortex. | 29097680 |
| Colorectal Cancer Pathway | Epigenetic Alterations | Analyzing epigenetic control of galectin expression indicates silencing of galectin-12 by promoter methylation in colorectal cancer. | 29098769 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | We therefore analyzed epigenetic mechanisms for control of galectin expression in 9 colorectal cancer (CRC) cell lines. | 29098769 |
| Transcriptional Regulator ATRX, Human, Malignant Neoplasms, Sarcoma - category (morphologic abnormality), Sarcoma, synovial sarcoma | Epigenetic Alterations | Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. | 29100075 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology, Leukemia, Myelocytic, Acute | Epigenetic Alterations | DICER1 gene and miRNA dysregulation in mesenchymal stem cells of patients with myelodysplastic syndrome and acute myeloblastic leukemia. | 29102598 |
| SF3B1 wt Allele, Leukemia, Myelocytic, Acute | Epigenetic Alterations | DICER1 gene expression was lower in MSC from MDS and AML patients than HC and some differentially expressed miRNAs indicated the potential involvement of DICER1 in the pathogenesis of MDS and AML. | 29102598 |
| SF3B1 wt Allele, MIR30A wt Allele, Leukemia, Myelocytic, Acute | Epigenetic Alterations | qRT-PCR confirmation revealed down-regulated miRNAs (hsa-miR-30d-5p, hsa-miR-222-3p and hsa-miR-30a-3p in MDS; hsa-miR-1275, hsa-miR-4725-5p and hsa-miR-143-3p in AML) and over-expressed miRNAs (hsa-miR-4462 in MDS; hsa-miR-134-5p and hsa-miR-874-3p in AML) in MDS and AML. | 29102598 |
| Primary malignant neoplasm | Epigenetic Alterations | We tested the DNA histograms, Cyclin D1 (CCND1) protein expression and CCND1 promoter DNA methylation in 40 pathologically confirmed specimens from As-BD patients to correlate with individuals invasive cancer occurrence in the 5-year follow-up. | 29103775 |
| Renal Cell Carcinoma Pathway | Epigenetic Alterations | MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma. | 29104726 |
| Prostate Cancer Pathway | Epigenetic Alterations | Previous studies suggest circulating, blood-based microRNAs (miRNAs) may serve as minimally invasive prostate cancer biomarkers, however there is limited data from prospective clinical trials. | 29105802 |
| Medullary carcinoma of thyroid | Epigenetic Alterations | MicroRNA-21 and long non-coding RNA MALAT1 are overexpressed markers in medullary thyroid carcinoma. | 29107050 |
| Stomach Carcinoma | Epigenetic Alterations | Long noncoding RNA LINC00675 enhances phosphorylation of vimentin on Ser83 to suppress gastric cancer progression. | 29107103 |
| Stomach Carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) play a crucial role in cancer development, but few lncRNAs have been functionally characterized in gastric cancer (GC). | 29107103 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation is an important epigenetic modification as a hallmark in cancer. | 29109788 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, long non-coding RNAs (lncRNAs) have been identified as new regulatory factors in human cancer cells. | 29110645 |
| Neoplasms | Epigenetic Alterations | Furthermore, microRNA-93 (miR-93) and Musashi-1 mediated the tumor suppression of LOCCS knockdown. | 29110645 |
| Malignant tumor of colon | Epigenetic Alterations | This comprehensive analysis of LOCCS in colon CSCs provides insight for elucidating important roles of the lncRNA-microRNA functional network in human colon cancer. | 29110645 |
| Metastasis, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are small non-coding RNAs of approximately nucleotides that regulate several aspects of tumors pathogenesis, including migration, invasion, metastasis and epithelial-mesenchymal transition. | 29111166 |
| Inflammatory, Mesothelioma, Primary malignant neoplasm | Epigenetic Alterations | We show that hypermethylation of p16/Ink4a and p19/Arf in CNT- and asbestos-induced inflammatory lesions precedes mesothelioma; this results in silencing of Cdkn2a (Ink4a/Arf) and loss of p16 and p19 protein, consistent with epigenetic alterations playing a gatekeeper role in cancer. | 29112861 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Suppression of microRNA-130b inhibits glioma cell proliferation and invasion, and induces apoptosis by PTEN/AKT signaling. | 29115407 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | The close association between the abnormal expression or mutation of microRNA (miRNA) and the tumorigenesis, progression and staging in glioma have been demonstrated previously. | 29115407 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | However, the expression pattern and specific role of microRNA-130b (miR-130b) in the tumor occurrence and progression of glioma are unclear. | 29115407 |
| Pancreatic carcinoma, Primary malignant neoplasm | Epigenetic Alterations | Prognostic microRNAs and their potential molecular mechanism in pancreatic cancer: A study based on The Cancer Genome Atlas and bioinformatics investigation. | 29115476 |
| cervical cancer, Metastasis | Epigenetic Alterations | microRNA-211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1. | 29115509 |
| Carcinogenesis | Epigenetic Alterations | An increasing number of studies have reported that microRNAs (miRNAs) have important roles in cervical cancer carcinogenesis and progression through regulation of various critical protein-coding genes. | 29115509 |
| Multiple System Atrophy | Epigenetic Alterations | Serum microRNA expression profiling in patients with multiple system atrophy. | 29115515 |
| Parkinson Disease, "Alzheimers Disease", Neurodegenerative Disorders, Amyotrophic Lateral Sclerosis | Epigenetic Alterations | It has been reported that dysregulation of microRNA (miRNA/miR) serves an important role in neurodegenerative disorders including Alzheimers disease, Parkinsons disease and amyotrophic lateral sclerosis. | 29115515 |
| Malignant Neoplasms | Epigenetic Alterations | HOX transcript antisense RNA (HOTAIR), a newly discovered long noncoding RNA (lncRNA), has been reported to be a poor prognostic marker in many types of cancers. | 29115524 |
| melanoma | Epigenetic Alterations | MicroRNA-326 inhibits melanoma progression by targeting KRAS and suppressing the AKT and ERK signalling pathways. | 29115540 |
| Malignant Neoplasms, melanoma | Epigenetic Alterations | An increasing number of studies have reported that microRNA (miRNA) dysregulation is frequently observed in various types of human cancers, including melanoma. | 29115540 |
| Neoplasms | Epigenetic Alterations | Recently, miRNA-326 (miR-326) has been reported to be differentially expressed in various types of tissues and play important roles in tumourigenesis and tumour development. | 29115540 |
| melanoma | Epigenetic Alterations | Abnormally expressed miRNAs play an important role in melanoma formation and progression by serving as potential biomarkers and therapeutic targets. | 29115540 |
| Intracranial Aneurysm | Epigenetic Alterations | Identification of key genes, transcription factors and microRNAs involved in intracranial aneurysm. | 29115560 |
| Seizures | Epigenetic Alterations | Downregulation of microRNA-155 by preoperative administration of VPA may prevent postoperative seizure by upregulating the expression of SCN1A. | 29115566 |
| CO-methylating acetyl-CoA synthase activity | Epigenetic Alterations | The data identified an ACS-specific DNA methylation profile with a large number of novel DM CpG sites, some of which may serve as candidate markers for the early diagnosis of ACS. | 29115576 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | Role of the microRNA 181 family in glioma development. | 29115595 |
| Neoplasms | Epigenetic Alterations | Recent evidence indicates that miRNAs have roles as tumor suppressors and oncogenes. | 29115595 |
| Neoplasms | Epigenetic Alterations | microRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer. | 29115941 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs have recently emerged as powerful regulators of cancer processes and become a promising target in cancer therapy. | 29116653 |
| Stomach Carcinoma | Epigenetic Alterations | Associations of Functional MicroRNA Binding Site Polymorphisms in IL23/Th17 Inflammatory Pathway Genes with Gastric Cancer Risk. | 29118466 |
| Stomach Carcinoma | Epigenetic Alterations | MicroRNA- (miRNA-) binding site single-nucleotide polymorphisms (SNPs) of inflammatory genes may alter gastric cancer (GC) susceptibility. | 29118466 |
| Primary malignant neoplasm | Epigenetic Alterations | Circulating cell-free miRNAs have emerged as promising minimally-invasive biomarkers for early detection, prognosis and monitoring of cancer. | 29121858 |
| Neurodegenerative Disorders | Epigenetic Alterations | Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases. | 29121998 |
| Antilymphocyte Serum, Parkinson Disease, Amyotrophic Lateral Sclerosis, Admitting diagnosis, palladium, "Alzheimers Disease", Frontotemporal dementia | Epigenetic Alterations | We describe the assessment of circulating brain-enriched microRNAs as potential biomarkers for Alzheimers disease (AD), frontotemporal dementia (FTD), Parkinsons disease (PD), and amyotrophic lateral sclerosis (ALS). | 29121998 |
| Rheumatoid Arthritis, Right arm | Epigenetic Alterations | Epigenetic mechanisms can integrate gene-environment interactions that mediate disease transition from preclinical to clinically overt rheumatoid arthritis (RA). | 29126434 |
| Right arm | Epigenetic Alterations | Whole blood expression profiling identified significantly differential miRNA expression in patients with RA (13 miRNAs) and FDRs (10 miRNAs) compared with HCs. | 29126434 |
| Right arm | Epigenetic Alterations | We highlight systematically altered circulating miRNA expression in at-risk FDRs prior to RA onset, a profile they shared with patients with RA. | 29126434 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Up-regulated miR-548k promotes esophageal squamous cell carcinoma progression via targeting long noncoding RNA-LET. | 29126868 |
| Malignant Neoplasms | Epigenetic Alterations | Dysregulated noncoding RNAs have been observed in diverse cancers. | 29126868 |
| Disease | Epigenetic Alterations | Long noncoding RNAs (lncRNAs) represent a novel class of noncoding RNAs that are involved in a variety of biological processes and human diseases. | 29129807 |
| MIR31HG gene, Primary malignant neoplasm | Epigenetic Alterations | Long non-coding RNA Loc554202 (lncRNA Loc554202) has been reported to be involved in the development of several types of cancer. | 29129878 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Valid evidence has demonstrated that microRNAs have critical functions in cancer genesis and tumor progression. | 29130108 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-329 inhibits cell proliferation and tumor growth while facilitates apoptosis via negative regulation of KDM1A in gastric cancer. | 29130516 |
| Stomach Carcinoma | Epigenetic Alterations | Altered expression of microRNA (miRNA) is strongly implicated in gastric cancer (GC). | 29130516 |
| Gastritis | Epigenetic Alterations | As opposed to adjacent tissues and gastritis tissues, miRNA-329 was highly expressed and KDM1A was low expressed in GC tissues. | 29130516 |
| Stomach Carcinoma | Epigenetic Alterations | Forced expression of miRNA-329 in gastric cancer cells significantly promotes their capacity of apoptosis but reduces proliferation, migration, and invasion. | 29130516 |
| Neoplasms | Epigenetic Alterations | In a nude mouse subcutaneous tumor system, in vivo tumor growth of BGC-823 was significantly inhibited after treatment of miRNA-329 mimics or siRNA against KDM1A. | 29130516 |
| Neoplasms | Epigenetic Alterations | We conclude that miRNA-329 functions as a tumor suppressor in GC, which could be achieved via transcriptional suppression of KDM1A. | 29130516 |
| Coronary Artery Disease | Epigenetic Alterations | Effects of MicroRNA-499 On the Inflammatory Damage of Endothelial Cells During Coronary Artery Disease Via the Targeting of PDCD4 Through the NF-Kb/TNF-a Signaling Pathway. | 29131009 |
| Malignant neoplasm of kidney | Epigenetic Alterations | MicroRNA-21 functions as an oncogene and promotes cell proliferation and invasion via TIMP3 in renal cancer. | 29131259 |
| Malignant Neoplasms, Refractory Cytopenia of Childhood | Epigenetic Alterations | More and more evidence identified microRNAs function as positive or negative regulatory factors in many cancers, but the role of miR-21 in RCC remains unclear. | 29131259 |
| Lymphoma | Epigenetic Alterations | In conclusion, we identified sets of dysregulated circulating miRNA that might serve as reliable biomarkers for relapsed lymphoma. | 29131834 |
| ovarian neoplasm | Epigenetic Alterations | Combining serum microRNA and CA-125 as prognostic indicators of preoperative surgical outcome in women with high-grade serous ovarian cancer. | 29132874 |
| Neoplasms | Epigenetic Alterations | This work demonstrates that hit-and-run epigenetic events can prevent senescence entry, which may facilitate tumour initiation. | 29133799 |
| Colon Carcinoma, Metastasis | Epigenetic Alterations | MicroRNAs and their role for T stage determination and lymph node metastasis in early colon carcinoma. | 29134398 |
| Primary malignant neoplasm | Epigenetic Alterations | In recent years, several studies have proposed a diagnostic and prognostic role for miRNAs in cancer. | 29134398 |
| Metastasis, Neoplasms | Epigenetic Alterations | Although miRNAs might not represent reliable biomarkers regarding lymph node metastasis status, they could support risk assessment in stage T1 tumors. | 29134398 |
| Lupus Nephritis | Epigenetic Alterations | We identified 24 circulating microRNAs with differential abundance between LN-IV and CTL groups, fourteen of these microRNAs are described for the first time to lupus nephritis (hsa-miR-589-3p, hsa-miR-1260b, hsa-miR-4511, hsa-miR-485-5p, hsa-miR-584-5p, hsa-miR-543, hsa-miR-153-3p, hsa-miR-6087, hsa-miR-3942-5p, hsa-miR-7977, hsa-miR-323b-3p, hsa-miR-4732-3p and hsa-miR-6741-3p). | 29136041 |
| Autoimmune Diseases, Lupus Erythematosus | Epigenetic Alterations | Altered miRNAs expression levels have been reported in human autoimmune diseases including lupus. | 29136041 |
| Lupus Nephritis | Epigenetic Alterations | Variations in the expression pattern of peripheral blood circulating miRNAs specific for this class of lupus nephritis could be correlated with the pathophysiological status of this group of individuals. | 29136041 |
| Arteriosclerosis | Epigenetic Alterations | Plenty of lncRNAs and microRNAs have been identified to be critical mediators in the progression of atherosclerosis (AS). | 29136944 |
| Neoplasms | Epigenetic Alterations | We observed significant miRNA expression variations among the three tumor groups. | 29138809 |
| Neoplasms | Epigenetic Alterations | This study suggests that these miRNAs may have potential value as tumor markers and implications for further understanding the molecular basis of these tumor types. | 29138809 |
| Neoplasms | Epigenetic Alterations | microRNAs (miRNAs) are a class of small, non-coding RNA molecules that serve important roles in biological and pathological processes in several types of human tumors. | 29138826 |
| Malignant Neoplasms, Renal Cell Carcinoma Pathway | Epigenetic Alterations | miRNA (miR)-660-5p is dysregulated in many human cancers; however, its role in renal cell carcinoma is currently unclear. | 29138826 |
| Primary malignant neoplasm | Epigenetic Alterations | Long noncoding RNAs (LncRNAs) have been shown to serve significant roles in the diagnosis and treatment of tongue cancer. | 29138845 |
| Stomach Carcinoma | Epigenetic Alterations | Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma. | 29138864 |
| Weight decreased | Epigenetic Alterations | INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program. | 29138870 |
| Weight decreased | Epigenetic Alterations | Diet-induced weight loss is also associated with differential global DNA methylation. | 29138870 |
| Weight decreased | Epigenetic Alterations | DNA methylation has been proposed as a predictive biomarker for weight loss response. | 29138870 |
| Weight decreased, Obesity | Epigenetic Alterations | In conclusion, a combination of genetic and epigenetic biomarkers may be used to design personalized weight loss interventions, enabling adherence and ensuring improved outcomes for obesity treatment programs. | 29138870 |
| Neoplasms | Epigenetic Alterations | The HOX transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), plays an important role in the pathogenesis and progression of multiple tumors. | 29141248 |
| Neoplasms | Epigenetic Alterations | MicroRNAs have been reported to play an important role in tumor development and progression by targeting oncogenes and tumor suppressors. | 29141872 |
| Hypertensive disease, Chronic Kidney Diseases | Epigenetic Alterations | Plasma microRNA-155-5p is increased among patients with chronic kidney disease and nocturnal hypertension. | 29146158 |
| Clinical Coordinator | Epigenetic Alterations | DNA methylation of the UQCRB promoter revealed that most CRC patients had high methylation levels (12/15 patients) in CRC tissues compared to non-tumor tissues. | 29147009 |
| Lymphoid neoplasm, Lymphoma | Epigenetic Alterations | These findings indicated that prenatal genetic or epigenetic changes influence risk of adult lymphoid neoplasms and suggest a difference in this association between aggressive and indolent lymphoma subtypes. | 29149251 |
| ovarian neoplasm | Epigenetic Alterations | Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition. | 29150601 |
| Stomach Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) may function as tumor suppressor or onco-miRNAs and have critical roles in the pathogenesis of gastric cancer (GC). | 29152656 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-216b inhibits cell proliferation and invasion in glioma by directly targeting metadherin. | 29152659 |
| Breast Cancer Cell, Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | A number of studies have indicated that the abnormal expression of specific microRNAs (miR) serves vital roles in the tumorigenesis and tumor development of human cancer, including glioma. | 29152659 |
| Malignant neoplasm of liver | Epigenetic Alterations | MicroRNA-137 has a suppressive role in liver cancer via targeting EZH2. | 29152663 |
| Liver carcinoma, Breast Cancer Cell, Metastasis, Hollings Cancer Center | Epigenetic Alterations | A variety of microRNAs (miRs) have been demonstrated to be associated with the development and malignant progression of human cancer; however, the regulatory mechanism of miR-137 underlying hepatocellular carcinoma (HCC) growth and metastasis still remains to be fully revealed. | 29152663 |
| Diabetes Mellitus | Epigenetic Alterations | Family history of diabetes is associated with enhanced adipose lipolysis: Evidence for the implication of epigenetic factors. | 29153750 |
| Diabetes Mellitus, Lipolysis | Epigenetic Alterations | Moreover, the influence on lipolysis was only observed in probands with a maternal history of diabetes, thereby supporting an epigenetic impact. | 29153750 |
| Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) are tissue specific, small, non-coding RNAs regulating gene expression, which may act as extracellular messengers of biological signals derived from the cross-talk between the tumor and its surrounding microenvironment. | 29155727 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening. | 29155727 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA Methylation of miR-7 is a Mechanism Involved in Platinum Response through MAFG Overexpression in Cancer Cells. | 29158814 |
| Primary malignant neoplasm | Epigenetic Alterations | Methods: We combined transcriptomic data from microRNA and mRNA under the influence of an epigenetic reactivation treatment in a panel of four paired cisplatin -sensitive and -resistant cell lines, followed by real-time expression and epigenetic validations for accurate candidate selection in 19 human cancer cell lines. | 29158814 |
| ovarian neoplasm | Epigenetic Alterations | Conclusion: The basal methylation status of miR-7 before treatment may be a potential clinical epigenetic biomarker, predictor of the chemotherapy outcome to CDDP in ovarian cancer patients. | 29158814 |
| Malignant neoplasm of ovary | Epigenetic Alterations | In the current study, we sought to identify epigenetically regulated microRNAs as novel biomarkers of platinum resistance in lung and ovarian cancers, the ones with highest ratios of associated chemo-resistance. | 29158814 |
| Malignant Neoplasms | Epigenetic Alterations | Aberrant promoter DNA methylation of the cysteine dioxygenase 1 (CDO1) gene is found in various human cancers and is associated with clinical outcome. | 29161283 |
| Ventricular Fibrillation, Cardiac Arrhythmia | Epigenetic Alterations | Larger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias. | 29162046 |
| Primary malignant neoplasm | Epigenetic Alterations | Folate metabolism is required for the production of DNA precursors and for proper DNA methylation reactions, and impaired folate metabolism has been often associated with cellular growth and cancer. | 29162511 |
| Clinical Coordinator, Colorectal Cancer Pathway | Epigenetic Alterations | Single-nucleotide polymorphisms (SNPs) in the promoter region of long intergenic non-coding RNAs (lincRNAs) could play a regulatory role in its expression level and then get involved in colorectal cancer (CRC). | 29167551 |
| Primary malignant neoplasm | Epigenetic Alterations | The prevalence of DNA methylation of the CpG island and shore within the promoter of the - 73C allele was much less than that of the - 73A allele in both gastric tissues and cancer cell lines. | 29168119 |
| Malignant Neoplasms | Epigenetic Alterations | MicroRNAs (miRs) have been reported to play significantly roles in the initiation and progression of human cancers. | 29170127 |
| Carcinoma of lung | Epigenetic Alterations | Identification of a serum microRNA expression signature for detection of lung cancer, involving miR-23b, miR-221, miR-148b and miR-423-3p. | 29173767 |
| palladium, Lung diseases | Epigenetic Alterations | The expression of serum miRNA from treatment-naive lung cancer patients (LC), benign pulmonary disease patients (PD) and healthy controls (HC) were examined by PCR array. | 29173767 |
| palladium, hydrocortisone | Epigenetic Alterations | Logistic regression and receiver operating characteristics curve analyses were used to identify differentially expressed miRNA signatures that could distinguish LC from PD and HC. | 29173767 |
| Liquid Chromatography | Epigenetic Alterations | These 4-miRNA signatures (miR-23b, miR-221, miR-148b and miR-423-3p) may be considered as novel, non-invasive biomarker for LC diagnosis. | 29173767 |
| Primary malignant neoplasm | Epigenetic Alterations | Serum mircoRNAs (miRNAs), with their noticeable stability and unique expression pattern in patients with various diseases, are powerful novel non-invasive biomarkers for cancer detection. | 29173767 |
| Carcinoma of lung | Epigenetic Alterations | The objective of this study was to identify specific serum miRNAs as potential diagnostic markers for detection of lung cancer. | 29173767 |
| palladium, hydrocortisone | Epigenetic Alterations | Ten miRNAs (let-7f, miR-126-3p, miR-148b, miR-151-5p, miR-199a-3p, miR-221, miR-23b, miR-26a, miR-27b, and miR-423-3p) in LC were significantly increased compared to those in PD and HC in biomarker-validation phase (P<0.05). | 29173767 |
| Primary malignant neoplasm | Epigenetic Alterations | Bioinformatic analyses showed that predicted targets of these miRNAs might have a correlation with formation and development of cancer. | 29173767 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-30e-5p suppresses non-small cell lung cancer tumorigenesis by regulating USP22-mediated Sirt1/JAK/STAT3 signaling. | 29174979 |
| Calcification of mitral valve | Epigenetic Alterations | Downregulated MicroRNA-195 in the Bicuspid Aortic Valve Promotes Calcification of Valve Interstitial Cells via Targeting SMAD7. | 29176317 |
| Liver carcinoma, Neoplasms | Epigenetic Alterations | Long Non-Coding RNA Linc-USP16 Functions As a Tumour Suppressor in Hepatocellular Carcinoma by Regulating PTEN Expression. | 29179215 |
| Neoplasms | Epigenetic Alterations | Recent evidence has indicated the crucial regulatory roles of long non-coding RNAs (lncRNAs) in tumour biology. | 29179215 |
| Tonsillar Squamous Cell Carcinoma, Human papilloma virus infection | Epigenetic Alterations | miRNA-expression in tonsillar squamous cell carcinomas in relation to HPV infection and expression of the antileukoproteinase SLPI. | 29179866 |
| EIPR1 gene | Epigenetic Alterations | RT-q-PCR-validation of the four most differentially expressed miRNAs showed that miR-363 is expressed strongest in SLPI-negative/HPV-positive TSSC. | 29179866 |
| Primary malignant neoplasm | Epigenetic Alterations | The expression of these three long noncoding RNAs was significantly higher in The Cancer Genome Atlas tumoral tissues. | 29182008 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNAs (miRNAs) have emerged as major regulators of tumour development and progression in non-small cell lung cancer (NSCLC). | 29183007 |
| Mammary Gland Parenchyma, Primary malignant neoplasm | Epigenetic Alterations | In addition to intergroup comparisons, plasma miRNA expression levels of all groups were analyzed against RNASeq data from cancerous breast tissue via The Cancer Genome Atlas (TCGA). | 29183284 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | The most striking findings revealed elevated tumor suppressor let-7 miRNA in luminal breast cancer patients, irrespective of subtype, and elevated miR-195 in plasma of TNBC breast cancer patients. | 29183284 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Robust expression of tumor suppressor miRNAs let-7 and miR-195 detected in plasma of Saudi female breast cancer patients. | 29183284 |
| MIRN195 microRNA, human, Neoplasms | Epigenetic Alterations | In contrast, hsa-miR-195 and let-7 miRNAs were absent from cancerous TCGA tissue and strongly expressed in surrounding non-tumor tissue indicating that cancerous cells may selectively export tumor suppressor hsa-miR-195 and let-7 miRNAs in order to maintain oncogenesis. | 29183284 |
| MIRN195 microRNA, human, Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | While studies have indicated that the restoration of let-7 and miR-195 may be a potential therapy for cancer, these results suggested that tumor cells may selectively export hsa-miR-195 and let-7 miRNAs thereby neutralizing their potential therapeutic effect. | 29183284 |
| Glomerulonephritis | Epigenetic Alterations | Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. | 29184126 |
| Rapidly progressive glomerulonephritis | Epigenetic Alterations | Here we demonstrate that microRNA-92a (miR-92a) is enriched in podocytes of patients and mice with RPGN. | 29184126 |
| Immune | Epigenetic Alterations | We demonstrate that miRNA induction in epithelial cells can break glomerular tolerance to immune injury. | 29184126 |
| Malignant tumor of colon | Epigenetic Alterations | Differences in the expression of serum miRNAs in patients with colon cancer and healthy controls were identified using miRNA microarrays. | 29187262 |
| Malignant tumor of colon | Epigenetic Alterations | Using these five miRNAs to construct a miRNA expression profile (or miRNA panel) will facilitate more effective diagnosis of colon cancer. | 29187262 |
| Malignant tumor of colon | Epigenetic Alterations | Microarray hybridization revealed that 87 miRNAs were differentially expressed between the sera of patients with colon cancer and healthy controls. | 29187262 |
| Disease, Primary malignant neoplasm | Epigenetic Alterations | The Mediator complex is a key regulator of gene transcription, and several studies have demonstrated altered expression of particular subunits in diverse human diseases, especially cancer. | 29187445 |
| Breast Carcinoma | Epigenetic Alterations | MicroRNA-588 is downregulated and may have prognostic and functional roles in human breast cancer. | 29187727 |
| Breast Cancer Cell | Epigenetic Alterations | BACKGROUND We explored the expression pattern, prognostic potential, and functional role of microRNA-588 (miR-588) in human breast cancer (BC). | 29187727 |
| Colorectal Cancer Pathway | Epigenetic Alterations | The NF-kB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression. | 29188362 |
| Clinical Coordinator | Epigenetic Alterations | Focusing on the genes and their associated miRNAs within the entire signalling pathway provides a comprehensive understanding of this complex pathway as it relates to CRC and offers insight into potential therapeutic agents. | 29188362 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Downregulation of microRNA-1274a induces cell apoptosis through regulation of BMPR1B in clear cell renal cell carcinoma. | 29192325 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Epigenetic Alterations | Our previous studies of the microRNA (miRNA) expression signature in clear cell renal cell carcinoma (ccRCC) indicated that miRNA-1274a (miR-1274a) was significantly upregulated in clinical specimens, suggesting that miR-1274a may act as an oncogenic miRNA in ccRCC. | 29192325 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Comparative Transcriptome Profiling Reveals Coding and Noncoding RNA Differences in NSCLC from African Americans and European Americans. | 29196495 |
| Neoplasms | Epigenetic Alterations | Comparative molecular profiling used mRNA (n = 22 AAs and 19 EAs) and miRNA (n = 42 AAs and 55 EAs) expression arrays to track differences in paired fresh frozen normal tissues and lung tumor specimens from AAs and EAs. | 29196495 |
| Primary malignant neoplasm, Neoplasms | Epigenetic Alterations | Pathway enrichment, predicted drug response, tumor microenvironment infiltration, cancer immunotherapy antigen profiling, and miRNA target enrichment were assessed.Results: AA-enriched differential gene expression was characterized by stem cell and invasion pathways. | 29196495 |
| ANOPHTHALMIA AND PULMONARY HYPOPLASIA | Epigenetic Alterations | We suggest that the intratumor histone H1.3 expression as reported herein, may serve as a new epigenetic biomarker for PDAC. | 29197353 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNAs have been validated to play a crucial role in tumorigenesis of non-small cell lung cancer (NSCLC). | 29197876 |
| Diabetes Mellitus | Epigenetic Alterations | A unique plasma microRNA profile defines type 2 diabetes progression. | 29200427 |
| diabetic | Epigenetic Alterations | In conclusion, we observed the major perturbation of plasma circulating microRNA in NP pre-diabetic subjects and identified a unique microRNA profile that may become helpful in predicting diabetic development. | 29200427 |
| Brugada Syndrome Ventricular Arrhythmia by ECG Finding, SCN5A gene | Epigenetic Alterations | H558R, a common SCN5A polymorphism, modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters. | 29202755 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | Recently, promoter methylation of PCDH10 was found in diffuse large B-cell lymphoma (DLBCL) but not in normal lymph nodes, suggesting that its epigenetic aberrance is essential to the lymphomagenesis. | 29202805 |
| Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA (lncRNA) H19 has been suggested to serve important roles in the progression of gastric cancer (GC); however, the mechanism involved is largely unknown. | 29207111 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | MicroRNA-133a acts as a tumour suppressor in breast cancer through targeting LASP1. | 29207145 |
| Breast Carcinoma, Neoplasms | Epigenetic Alterations | Many microRNAs (miRs) have been demonstrated to play promoting or tumor suppressive roles in human cancers including breast cancer. | 29207145 |
| cervical cancer | Epigenetic Alterations | Long non-coding nuclear paraspeckle assembly transcript 1 acts as prognosis biomarker and increases cell growth and invasion in cervical cancer by sequestering microRNA-101. | 29207151 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Both defective DNA methylation and active DNA demethylation processes are emerging as important risk factors in chronic lymphocytic leukemia (CLL). | 29209431 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | Combining cytogenetic and epigenetic approaches in chronic lymphocytic leukemia improves prognosis prediction for patients with isolated 13q deletion. | 29209431 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | However, associations between 5-cytosine epigenetic markers and the most frequent chromosomal abnormalities detected in CLL remain to be established. | 29209431 |
| Primary malignant neoplasm | Epigenetic Alterations | In cancer, glycolysis driving enzymes and their regulating microRNAs are one of the key focus of oncology research lately. | 29220380 |
| Chronic Obstructive Airway Disease | Epigenetic Alterations | Recent data have suggested that some miRNAs are involved in the pathogenesis of COPD. | 29223853 |
| Pancreatic carcinoma | Epigenetic Alterations | MicroRNA-195 Suppresses the Progression of Pancreatic Cancer by Targeting DCLK1. | 29224010 |
| Neoplasms | Epigenetic Alterations | MicroRNA-195 (miR-195) plays an important role in many types of tumors. | 29224010 |
| Clinical Coordinator | Epigenetic Alterations | Frequent aberrant DNA methylation is known to occur in selected genes and early during CRC development, which has emerged as a new epigenetic biomarker for early detection of CRC. | 29225717 |
| Malignant tumor of colon | Epigenetic Alterations | MicroRNA-transcription factor interactions and their combined effect on target gene expression in colon cancer cases. | 29226599 |
| Colorectal Cancer Pathway | Epigenetic Alterations | We used known TF binding sites and validated miRNA targets to determine potential miRNA-TF-TG interactions, restricting interactions to those with a TF previously associated with altered risk of colorectal cancer death. | 29226599 |
| thyroglobulin | Epigenetic Alterations | Additionally, miRNAs and TFs alter each others expression, making it difficult to ascertain the effect either one has on target gene (TG) expression. | 29226599 |
| thyroglobulin | Epigenetic Alterations | Our results show that TG expression is influenced by both miRNAs as well as TFs, and the influence of one regulator impacts the effect of the other on the shared TG expression. | 29226599 |
| Primary malignant neoplasm, Squamous cell carcinoma of esophagus | Epigenetic Alterations | Our results suggested that the miRNA machinery gene expression-associated miR-SNPs would modify cancer outcomes; in this light, XPO5 may be an important new target for ESCC therapy. | 29226993 |
| Renal Cell Carcinoma | Epigenetic Alterations | MicroRNA-155 (MiR-155) was found to be upregulated in renal carcinoma tissue. | 29228417 |
| Carcinoma of lung | Epigenetic Alterations | Expressions of microRNA-876-5p and its potential target BMP-4 were analysed in lung cancer cells and patient tissues. | 29229885 |
| Carcinoma of lung, Neoplasms | Epigenetic Alterations | A xenograft tumour mouse model was established to address the roles of microRNA-876-5p and BMP-4 in lung cancer EMT in vivo. | 29229885 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA-876- 5p was decreased while BMP-4 was increased in lung cancer cells and tissues. | 29229885 |
| Carcinoma of lung, Metastasis | Epigenetic Alterations | MicroRNA-876-5p expression significantly inhibited the migration, invasion and EMT of lung cancer cells in vitro, as well as metastasis in vivo, which required BMP-4 expression. | 29229885 |
| Carcinoma of lung | Epigenetic Alterations | MicroRNA-876-5p suppresses EMT of lung cancer by directly down-regulating BMP-4, both of which could serve as potential therapeutic targets in the treatment of lung cancer. | 29229885 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | The involvement of passenger strand miRNA in the regulation of HNSCC pathogenesis is a novel concept in RNA research. | 29233721 |
| Primary malignant neoplasm | Epigenetic Alterations | Our recent studies have revealed that both strands of pre-miRNAs, the guide strand and the passenger strand, are involved in cancer pathogenesis. | 29233721 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | mRNA and miRNA expression was determined using TaqMan assays in 110 early-stage NSCLC patients. | 29237428 |
| Disease | Epigenetic Alterations | Circular RNAs (circRNAs), which are stable and conserved non-coding RNA in mammalian cells, have been reported to be widely involved in the processes of cancer disease. | 29241190 |
| Multiple Myeloma, Morular Metaplasia of the Endometrium | Epigenetic Alterations | As the promoter region of its host gene, EVL, is embedded in a CpG island, we postulated that miR-342-3p is an intronic miRNA co-regulated with its host gene by promoter DNA methylation in multiple myeloma (MM). | 29242101 |
| Multiple Myeloma | Epigenetic Alterations | Epigenetic silencing of EVL/miR-342 in multiple myeloma. | 29242101 |
| Malignant Neoplasms, Neoplasms | Epigenetic Alterations | miR-342-3p, localized to 14q32, is a tumor suppressor miRNA implicated in multiple cancers. | 29242101 |
| Diffuse Large B-Cell Lymphoma | Epigenetic Alterations | To identify biological correlates for treatment resistance, we profiled microRNAs (miRNAs) of matched primary and relapsed DLBCL by next-generation sequencing. | 29242506 |
| cervical cancer | Epigenetic Alterations | MiRNA-338-3p regulates cervical cancer cells proliferation by targeting MACC1 through MAPK signaling pathway. | 29243777 |
| Neoplasms | Epigenetic Alterations | Long non-coding RNA CRNDE is a novel tumor promoter by modulating PI3K/AKT signal pathways in human gastric cancer. | 29243780 |
| Malignant Neoplasms, Stomach Carcinoma | Epigenetic Alterations | Long non-coding RNA CRNDE (CRNDE) recently emerged as a carcinogenic promoter in various cancers including gastric cancer (GC). | 29243780 |
| Metastasis, Squamous cell carcinoma of esophagus, Neoplasms | Epigenetic Alterations | Our results thus suggest that LUCAT1 regulates the stability of DNMT1 and inhibits the expression of tumor suppressors through DNA methylation, leading to the formation and metastasis of ESCC. | 29247823 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma. | 29247823 |
| Malignant Neoplasms | Epigenetic Alterations | Recently, many long noncoding RNAs (lncRNAs) have been reported to be involved in various cancers. | 29247823 |
| Head and Neck Carcinoma | Epigenetic Alterations | Aberrations in Wnt signaling pathway are related to the pathogenesis of head and neck carcinomas and their activation frequently results from epigenetic alterations. | 29254794 |
| Oral Cavity Carcinoma, Neoplasms | Epigenetic Alterations | Our findings corroborate that DAB2 is a frequent target of epigenetic silencing in oral carcinomas and may be potentially used for tumor detection. | 29254794 |
| Degenerative polyarthritis | Epigenetic Alterations | We identified a three-miRNA signature, hsa-miR-140-3p, hsa-miR-671-3p, and hsa-miR-33b-3p, in the serum of OA patients, predicted to regulate metabolic processes, which could serve as a potential biomarker for the evaluation of OA risk and progression. | 29255496 |
| Degenerative polyarthritis | Epigenetic Alterations | We identified 279 differentially expressed miRNAs in the serum of OA patients compared to controls. | 29255496 |
| Degenerative polyarthritis | Epigenetic Alterations | qRT-PCR validation in seven selected out of the 77 miRNAs revealed 3 significantly downregulated miRNAs (hsa-miR-33b-3p, hsa-miR-671-3p, and hsa-miR-140-3p) in the serum of OA patients, which were in silico predicted to be enriched in pathways involved in metabolic processes. | 29255496 |
| Glioblastoma Multiforme | Epigenetic Alterations | MicroRNA-376a inhibits cell proliferation and invasion in glioblastoma multiforme by directly targeting specificity protein 1. | 29257212 |
| Malignant Neoplasms | Epigenetic Alterations | miRNA (miR)-376a is abnormally expressed in multiple human cancers; however, the expression pattern and role of miR-376a in GBM, and the underlying molecular mechanisms by which miR-376a exerts its functions remain to be elucidated. | 29257212 |
| Primary malignant neoplasm | Epigenetic Alterations | microRNAs (miRNAs) are aberrantly expressed in numerous cancer types, including GBM. | 29257212 |
| Metastasis | Epigenetic Alterations | Abnormally expressed miRNAs are commonly associated with malignant characteristics of GBM, including malignant growth, proliferation, apoptosis, invasion, metastasis and resistance to chemotherapy. | 29257212 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miR)-455-5p has been identified as a biomarker for various types of cancer and may therefore be involved in the regulation of cancer development and progression. | 29257232 |
| Primary malignant neoplasm | Epigenetic Alterations | Recently, microRNAs (miRs) have been considered as novel therapeutic targets for the treatment of cancer. | 29257251 |
| Metastasis, Primary malignant neoplasm | Epigenetic Alterations | MicroRNA (miR)-185, which has been reported to be abnormally expressed in some types of cancer, exerts significant effects on the proliferation, apoptosis, drug resistance and metastasis of cancer cells. | 29257260 |
| Intervertebral disc disorder | Epigenetic Alterations | The effects of long non-coding RNAs on the proliferation and development of IDD have attracted increasing attention. | 29257270 |
| Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNA-103 suppresses glioma cell proliferation and invasion by targeting the brain-derived neurotrophic factor. | 29257320 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | MicroRNAs (miRNAs/miRs) are involved in tumour development of various human cancers, including glioma. | 29257320 |
| Neoplasms, Glioblastoma Multiforme Pathway | Epigenetic Alterations | Therefore, miRNAs may have potential tumour diagnostic, prognostic and therapeutic values in human glioma. | 29257320 |
| Neoplasms | Epigenetic Alterations | MicroRNA-373 (miR-373) has been reported to be an oncogene in a number of solid human tumors. | 29257346 |
| Metastasis, Adenocarcinoma of lung (disorder) | Epigenetic Alterations | The ceRNA network revealed that 10 microRNAs (miRs; including miR-16-5p and miR-214-3p), 123 long non-coding RNAs (including X-inactive specific transcript, H19 and metastasis associated lung adenocarcinoma transcript 1) and 408 circular RNAs (including ATP-binding cassette subfamily C member 1 hsa_circ_001569 and ISY1 splicing factor homolog hsa_circ_001859) may regulate the expression of FOXP3, IL-10 and CD274. | 29257349 |
| Electrocardiogram: myocardial infarction (finding) | Epigenetic Alterations | Circulating Long Noncoding RNA HOTAIR is an Essential Mediator of Acute Myocardial Infarction. | 29258067 |
| Matrix Metalloproteinase 9, Diabetes Mellitus | Epigenetic Alterations | Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes. | 29261844 |
| Diabetes Mellitus | Epigenetic Alterations | MMP-9 promoter has binding sites for many transcription factors, and in diabetes its promoter undergoes epigenetic modifications, including histone modifications and DNA methylation. | 29261844 |
| Diabetes Mellitus | Epigenetic Alterations | Activation of Ezh2 in diabetes, via trimethylation of H3K27, facilitates recruitment of the enzymes responsible for regulation of DNA methylation of the MMP-9 promoter, resulting in its transcriptional activation. | 29261844 |
| Diabetes Mellitus | Epigenetic Alterations | Thus, a close crosstalk between H3K27 trimethylation and DNA methylation in diabetes plays a critical role in the maintenance of cellular epigenetic integrity of MMP-9. | 29261844 |
| Primary malignant neoplasm | Epigenetic Alterations | Histones undergo extensive post-translational modifications and this epigenetic regulation plays an important role in modulating transcriptional programs capable of driving cancer progression. | 29262808 |
| Primary malignant neoplasm | Epigenetic Alterations | Aberrant circulating DNA methylation (DNAme) patterns are likely to provide a highly specific cancer signal. | 29268762 |
| ovarian neoplasm, Neoplasms | Epigenetic Alterations | The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer. | 29268796 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC). | 29270239 |
| Primary malignant neoplasm | Epigenetic Alterations | DNA methylation has been implicated as a promising biomarker for precise cancer diagnosis. | 29270239 |
| Squamous cell carcinoma of esophagus | Epigenetic Alterations | However, limited DNA methylation-based biomarkers have been described in esophageal squamous cell carcinoma (ESCC). | 29270239 |
| Squamous cell carcinoma of esophagus, Primary malignant neoplasm | Epigenetic Alterations | A high-throughput DNA methylation dataset (100 samples) of ESCC from The Cancer Genome Atlas (TCGA) project was analyzed and validated along with another independent dataset (12 samples) from the Gene Expression Omnibus (GEO) database. | 29270239 |
| Carcinoma of lung | Epigenetic Alterations | Bronchial biopsy specimen as a surrogate for DNA methylation analysis in inoperable lung cancer. | 29270240 |
| Primary malignant neoplasm | Epigenetic Alterations | MicroRNAs are small endogenous non-coding RNAs, which can frequently emerge as regulators in many cancer types. | 29275213 |
| Left Ventricular Hypertrophy | Epigenetic Alterations | Serum MicroRNA-27b as a Screening Biomarker for Left Ventricular Hypertrophy. | 29276436 |
| Squamous cell carcinoma of the head and neck, Tumor Promoters | Epigenetic Alterations | Herein we report for the first time that miR-1275 could act as a tumor-promoter in SCCHN possibly by regulating its target gene via novel miRNA mechanisms. | 29278769 |
| Squamous cell carcinoma of the head and neck | Epigenetic Alterations | miRNAs can play vital role in migration, invasion and proliferation in Squamous cell carcinoma of head and neck (SCCHN). | 29278769 |
| Malignant Neoplasms, Primary malignant neoplasm | Epigenetic Alterations | The analysis of our original miRNA expression signatures of human cancers revealed that microRNA-150-5p (miR-150-5p) was downregulated in various types of cancer, indicating that miR-150-5p acts as an antitumor miRNA by targeting several oncogenic genes. | 29286099 |
| Squamous cell carcinoma of lung | Epigenetic Alterations | Downregulation of matrix metalloproteinase 14 by the antitumor miRNA, miR-150-5p, inhibits the aggressiveness of lung squamous cell carcinoma cells. | 29286099 |
| Metastasis, Non-Small Cell Lung Carcinoma | Epigenetic Alterations | MicroRNA-454 inhibits non-small cell lung cancer cells growth and metastasis via targeting signal transducer and activator of transcription-3. | 29286124 |
| Non-Small Cell Lung Carcinoma | Epigenetic Alterations | Emerging studies have suggested that microRNAs are dysregulated in NSCLC and serve important roles in NSCLC initiation and development. | 29286124 |
"
| SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Epigenetic Alterations | Utility of 5-Methylcytosine Immunohistochemical Staining to Assess Global DNA Methylation and Its Prognostic Impact in MDS Patients Background: DNA methylation plays a vital role in the pathogenesis of the myelodysplastic syndrome (MDS),
a heterogeneous group of clonal hematopoietic stem cell (HSC) disorders. | 29286224 | "
| Vulval intraepithelial neoplasia, CARCINOMA OF VULVA | Epigenetic Alterations | Normalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma. | 29299981 |
| Vulval intraepithelial neoplasia, Squamous cell carcinoma of vulva | Epigenetic Alterations | Our work is the first report on reference microRNA selection for quantitative real-time polymerase chain reaction applications in vulvar intraepithelial neoplasia lesion and vulvar squamous cell carcinoma. | 29299981 |
| Vulval intraepithelial neoplasia, Squamous cell carcinoma of vulva | Epigenetic Alterations | To date, no suitable reference microRNAs for normalizing quantitative real-time polymerase chain reaction assays has been identified in vulvar intraepithelial neoplasia lesions and vulvar squamous cell carcinoma. | 29299981 |
| Vulval intraepithelial neoplasia, Squamous cell carcinoma of vulva | Epigenetic Alterations | The results pointed at hsa-miR-93-5p and hsa-miR-425-5p as microRNAs that retained the greatest robustness in plasma of vulvar intraepithelial neoplasia lesion and vulvar squamous cell carcinoma patients, respectively. | 29299981 |
| Malignant neoplasm of larynx, Neoplasms | Epigenetic Alterations | The secondary endpoint was to identify specific deregulated miRNAs with potential as prognostic biomarkers for tumour spread and nodal involvement, and specifically to search for a miRNA pattern pathognomonic for N+ laryngeal cancer and for N- tissues. | 29327732 |
| Malignant neoplasm of larynx, Carcinoma of larynx | Epigenetic Alterations | We identified 20 miRNAs specific for laryngeal cancer and a tissue-specific miRNA signature that is predictive of lymph node metastases in laryngeal carcinoma characterised by 11 miRNAs, seven of which are overexpressed (upregulated) and four downregulated. | 29327732 |
| Neoplasms | Epigenetic Alterations | The discovery that miRNAs are frequently deregulated in tumours offers the opportunity to identify them as prognostic and diagnostic markers. | 29327732 |
| Malignant Neoplasms, Aggressive behavior | Epigenetic Alterations | MicroRNAs have been shown to modulate the aggressiveness of various cancers, and have emerged as possible therapeutic agents for the management of GBM. | 29345288 |
| Malignant Neoplasms, Colorectal Cancer Pathway | Epigenetic Alterations | Deregulated levels of miRNA were found in many types of cancers including colorectal cancer. | 29355387 |
| Neoplasms | Epigenetic Alterations | Our results showed an up-regulation of all measured miRNAs in tumor tissue compared to adjacent tissues. | 29355387 |
| Neoplasms | Epigenetic Alterations | As expected, tumors and adjacent tissues exhibited a significantly higher expression of leading miRNAs compared to passenger strand of miR-21 and miR-16. | 29355387 |
| Congenital contractural arachnodactyly | Epigenetic Alterations | Although aberrant DNA methylation in CCA has been reported by several investigators, little is known regarding the associations between them. | 29359783 |
| Congenital contractural arachnodactyly | Epigenetic Alterations | In conclusion, the present study revealed the value of aberrant DNA methylation of HTATIP2 and UCHL1, which may serve as a potential predictive biomarker for CCA. | 29359783 |
| Malignant neoplasm of endometrium | Epigenetic Alterations | DNA methylation as mechanism of apoptotic resistance development in endometrial cancer patients. | 29372685 |
| Carcinogenesis | Epigenetic Alterations | Aberrant DNA methylation changes result in deregulation of important apoptotic proteins during endometrial carcinogenesis and apoptosis resistance development. | 29372685 |
| Carcinogenesis | Epigenetic Alterations | We observed as the first a significant difference in promoter DNA methylation status in genes: BCL2L11 (p < 0.001), CIDEB (p < 0.03) and GADD45A (p < 0.05) during endometrial carcinogenesis and BIK gene (p < 0.03) in different phases of normal menstrual cycle. | 29372685 |
| Degenerative polyarthritis | Epigenetic Alterations | Recent studies suggest that cytokines and microRNAs play a key role in the destruction of cartilage matrix in osteoarthritis (OA) tissues. | 29441883 |
| Antilymphocyte Serum, Amyotrophic Lateral Sclerosis | Epigenetic Alterations | The occurrence of mutations of TDP-43, FUS, and C9ORF72 in amyotrophic lateral sclerosis (ALS) suggests pathogenic alterations to RNA metabolism and specifically to microRNA (miRNA) biology. | 29458840 |
| Antilymphocyte Serum | Epigenetic Alterations | Then, we tested this set of miRNAs in the serum from sporadic ALS patients, observing a significant deregulation of hsa-miR-142-3p and hsa-miR-1249-3p. | 29458840 |
| Chronic Lymphocytic Leukemia | Epigenetic Alterations | MicroRNA-155-5p Overexpression in Peripheral Blood Mononuclear Cells of Chronic Lymphocytic Leukemia Patients Is a Novel, Independent Molecular Biomarker of Poor Prognosis. | 29463948 |
| Inflammation | Epigenetic Alterations | MicroRNA-155-5p (miR-155-5p) is a proinflammatory, oncogenic miRNA, involved in various physiological processes, including hematopoiesis, immunity, inflammation, and cell lineage differentiation. | 29463948 |
| Extrahepatic Cholangiocarcinoma | Epigenetic Alterations | DNA Methylation Markers Improve the Sensitivity of Endoscopic Retrograde Cholangiopancreatography-Based Brushing Cytology in Extrahepatic Cholangiocarcinoma. | 29484968 |
| Malignant Biliary Obstruction | Epigenetic Alterations | In conclusion, measurement of the DNA methylation status of HOXA1 and NEUROG1 genes in leftover brushed biliary cells might serve as a useful supplement in the detection of malignant biliary obstruction by increasing the sensitivity of diagnosis by routine cytology. | 29484968 |
| Carcinoma, Ovarian Epithelial | Epigenetic Alterations | Long non-coding RNAs (lncRNAs) have been proved to play important roles in the tumorigenesis and development of human epithelial ovarian cancer (EOC). | 29693889 |