AgingHallmarkDB


Epigenetic Alterations

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Matched Disease Name Matched Aging Hallmark Sentence PMID
Malignant tumor of colon, Neoplastic diseaseEpigenetic AlterationsBecause aberrant DNA methylation may contribute to the initiation or progression of colon cancer, we hypothesized that deficient intakes of folate or methionine and high consumption of alcohol, an antagonist of methyl-group metabolism, increase risk of colon neoplasia.7707417
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation.7858479
Carcinoma, AdenomaEpigenetic AlterationsIntrinsic DNA methylation was significantly lower in carcinomas than in adenomas (P < 0.005).7858479
Depressed moodEpigenetic AlterationsThe fact that not all cases with elevated ERBB2 mRNA synthesis were immunohistochemically positive suggests that either immunohistochemistry (after fixation with 10% formalin) is a less sensitive method than in situ hybridization to detect abnormal gene expression or that there are cases in which the oncoprotein synthesis is for some reason depressed, even though there is an increase in gene transcription.7910618
DeficitEpigenetic AlterationsThis pattern of cytokine gene transcription may explain functional deficits of TIL.8029672
Burn injury, Depressed moodEpigenetic AlterationsAltered gene transcription after burn injury results in depressed T-lymphocyte activation.8092900
Glioma, Glioblastoma Multiforme PathwayEpigenetic AlterationsIn an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA.8645431
NeoplasmsEpigenetic AlterationsThe total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations.8645431
Alzheimers DiseaseEpigenetic AlterationsThis is the first report of an epigenetic defect in an Alzheimers disease patient and the observation suggests that hypomethylation of the APP gene may be one of several factors contributing to aberrant gene expression in Alzheimers disease.8746452
Liver carcinoma, Retinoblastoma, Hollings Cancer CenterEpigenetic AlterationsAlthough genetic changes of Rb gene have been described in hepatocellular carcinoma (HCC), an epigenetic change such as hypermethylation of the Rb promoter as reported in retinoblastoma has not been described.8908549
Colorectal NeoplasmsEpigenetic AlterationsDNA hypomethylation and proliferative activity are increased in this group of patients, supporting the concept that their colonic mucosa undergoes epigenetic and kinetic changes that might predispose these individuals to develop colorectal neoplasms.8940998
Childhood LeukemiaEpigenetic AlterationsThese data (1) provide strong genetic evidence that NF1 functions as a tumor-suppressor in early myelopoiesis, (2) confirm the clonal nature of JCML/JMML, (3) suggest that the elevation in fetal hemoglobin seen in JCML/JMML is a result of primary involvement of erythroid progenitors in the malignant clone, (4) show consistent loss of NF1 in the CD34 cells of affected children and show that the malignant clone may also give rise to pre-B cells in some cases, and (5) implicate epigenetic factors in the development of leukemia in children with NF1.8943868
X-linked inheritanceEpigenetic AlterationsMoreover, DNA methylation of X-linked genes in hematopoietic cells may differ from that in other tissues.8978285
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsAbnormal c-myc oncogene DNA methylation in human bladder cancer: possible role in tumor progression.9076471
Breast CarcinomaEpigenetic AlterationsOur data show that YB-1 has an important role in controlling MDR1 gene transcription and this finding provides a basis for the analysis of molecular mechanisms responsible for intrinsic multidrug resistance in human breast cancer.9095180
Human papillomavirus 16Epigenetic AlterationsDetection of human papillomavirus type 16 early-gene transcription by reverse transcription-PCR is associated with abnormal cervical cytology.9163482
Malignant tumor of colonEpigenetic AlterationsAre dietary factors involved in DNA methylation associated with colon cancer?9200151
CarcinogenesisEpigenetic AlterationsDisturbances in DNA methylation have been hypothesized as being involved in carcinogenesis.9200151
Malignant tumor of colonEpigenetic AlterationsIt has been proposed that dietary factors such as folate, alcohol, and methionine may be associated with colon cancer because of their involvement in DNA methylation processes.9200151
Malignant tumor of colonEpigenetic AlterationsFindings from this study provide only limited support for previously reported associations between dietary factors involved in DNA methylation and risk of colon cancer.9200151
Infective cervicitisEpigenetic AlterationsGenomic deletion on 3p and 5p was correlated with genetic or epigenetic p53 inactivation pathways, including p53 mutation, genetic deletion of p53 and cervical infection with human papillomavirus.9219832
NeoplasmsEpigenetic AlterationsAlthough not all tumors were hypermethylated, these observations are consistent with an important role for epigenetic mechanisms in human cancer.9269993
HRAS wt Allele, CarcinogenesisEpigenetic AlterationsAlterations of level of total genomic DNA methylation and pattern of c-myc, c-Ha-ras oncogene methylation in human gastric carcinogenesis.9275356
Myeloid Leukemia, ChronicEpigenetic AlterationsWe previously reported that the abl promoter (Pa) undergoes de novo DNA methylation in the course of chronic myelocytic leukemia (CML).9389709
NeoplasmsEpigenetic AlterationsAberrant DNA methylation has been observed consistently in many human tumours, in particular in the CpG islands of tumour suppressor genes, but the underlying mechanism of these changes remains unclear.9529124
Prostate Cancer PathwayEpigenetic AlterationsThese results indicate that mutations in p16 may not be a dominant pathway for p16 loss of function or that inactivation of p16 by DNA methylation may not be necessary for the transformation and progression of prostate cancer.9537647
Primary central nervous system lymphomaEpigenetic AlterationsIn summary, inactivation of CDKN2A by either homozygous deletion or DNA methylation represents an important molecular mechanism in PCNSL.9546285
Peripheral T-Cell LymphomaEpigenetic AlterationsAmplification of the TCL1 flanking region at 14q32.1 with no TCL1 gene transcription in a patient with peripheral T cell lymphoma.9639427
NeuroblastomaEpigenetic AlterationsStrong NF-kappaB-DNA binding has been reported previously to temporally precede COX-2 gene transcription in human epithelial (A549), hamster B-cell (HIT-T15), human endothelial (HUVEC), human lymphoblast (IM9), human fibroblast (IMR90), rat glioma/mouse neuroblastoma (NG108-15), human keratinocyte (NHEK), mouse fibroblast (NIH 3T3), rat neuroblastoma (SH-SY5Y) cell lines and in mouse and rat brain hippocampus, indicating a highly conserved inflammatory signaling pathway that is common to diverse species and cell types.9726429
Discordance, "Sotos syndromeEpigenetic AlterationsOur finding of discordance in these identical twins suggests that a postconceptual mutation, or epigenetic change and/or an environmental factor may be involved in the cause of Sotos syndrome.9781916
Liver carcinomaEpigenetic AlterationsCorrelation between DNA methylation and pathological changes in human hepatocellular carcinoma.9840141
Hollings Cancer CenterEpigenetic AlterationsIn addition, we measured the level of global DNA methylation in cancerous and paracancerous tissues of HCC by incubating DNA with 3H-S-adenosylmethionine (3H-SAM) in the presence of methylase.9840141
Liver carcinomaEpigenetic AlterationsThe results showed that the hypomethylation rates of c-myc and c-N-ras oncogenes were 30% and 61% respectively in human hepatocellular carcinoma, coinciding with a decreased level of global DNA methylation.9840141
HepatocarcinogenesisEpigenetic AlterationsIt is concluded that abnormal DNA methylation plays an important role in the process of hepatocellular carcinogenesis.9840141
Malignant neoplasm of liverEpigenetic AlterationsDNA methylation level is closely correlated with the biological characteristic of liver cancer, the lower the level of DNA methylation, the stronger the infiltration and metastatic capacity.9840141
Colorectal, Primary malignant neoplasmEpigenetic AlterationsAging and DNA methylation in colorectal mucosa and cancer.9850084
Colorectal Cancer Pathway, Multiple Endocrine Neoplasia, NeoplasmsEpigenetic AlterationsDNA methylation of promoter-associated CpG islands may function as an alternate mechanism of silencing tumor suppressor genes in multiple neoplasias including colorectal cancer.9850084
TSPYL2 wt AlleleEpigenetic AlterationsBecause c-Myc/Max heterodimers are strong gene transcription activators and are necessary for cell-cycle progression, they may play a role in the progression of CTCL.9864169
Carcinogenesis, NeoplasmsEpigenetic AlterationsThe predominance of G:C-->A:T transitions at CpG sites, which are associated with methyltransferase-induced DNA methylation at carbon 5 of cytosine, in all three tumor types suggests that the status of DNA methylation may be the major determinant for p53 mutations and may be also equally important in gastric carcinogenesis regardless of histology.9886570
Liver neoplasmsEpigenetic AlterationsThese results suggest that circulating liver tumor DNA may be detected using tumor-associated DNA methylation changes.9892188
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsWe examined a total of 34 tumours from 30 hepatocellular carcinoma (HCC) patients for deletion, mutation and DNA methylation of these two genes by polymerase chain reaction (PCR) amplification, sequence analysis and Southern blot.9893670
Liver carcinomaEpigenetic AlterationsHigh levels of DNA methylation were detected in 24 of 29 cases of hepatocellular carcinoma with negative p16(INK4) expression, with methylation of 60%-85% of the CpG islands.9922321
Liver carcinoma, NeoplasmsEpigenetic AlterationsA strong correlation was found between the extent of methylation and the degree of expression of p16(INK4) in tumor tissues, indicating that epigenetic change due to extensive CpG methylation is the main cause of inactivation of p16(INK4) in hepatocellular carcinoma.9922321
Breast CarcinomaEpigenetic AlterationsInterestingly, most cases with MI at the region encoding for p16 were aggregated in a subgroup of breast carcinomas with no other obvious genetic and/or epigenetic CDKN2/p16(INK4A) alterations.9990866
Hepatocarcinogenesis, HCCS gene, Neoplasms, Liver carcinomaEpigenetic AlterationsTo examine the significance of aberrant DNA methylation in hepatocarcinogenesis, the DNA methylation status at the D17S5 locus and mRNA expression of a candidate tumor suppressor gene, HIC-1 (hypermethylated-in-cancer), which was identified at the D17S5 locus, in primary hepatocellular carcinomas (HCCs) and their corresponding noncancerous liver tissues were assessed.10051471
HepatocarcinogenesisEpigenetic AlterationsThese data suggest that aberrant DNA methylation at this locus and reduced HIC-1 mRNA expression participate in hepatocarcinogenesis during both early developmental stages and malignant progression of HCCs.10051471
NeoplasmsEpigenetic AlterationsAlterations in DNA methylation in tumours have been reported and have been used to generate hypotheses about mutagenesis and silencing of tumour suppressor genes.10071236
Colonic adenomasEpigenetic AlterationsEffect of folate supplementation on DNA methylation of rectal mucosa in patients with colonic adenomas: correlation with nutrient intake.10205316
CystadenocarcinomaEpigenetic AlterationsThis indicates that cystadenocarcinomas have a mixed biological phenotype and suggests they could arise either from pluripotent cells or from neoplastic cells that reacquire epigenetic features.10207666
melanomaEpigenetic AlterationsHeterogeneity of HLA-G gene transcription and protein expression in malignant melanoma biopsies.10213506
melanomaEpigenetic AlterationsThis work provides evidence that HLA-G gene transcription and protein expression can be up-regulated ex vivo in melanoma.10213506
Adenocarcinoma of prostateEpigenetic AlterationsHigh frequency of alterations in DNA methylation in adenocarcinoma of the prostate.10334105
Small cell carcinoma of lung, Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsThe p16INK4A tumor suppressor gene is frequently inactivated in non-small cell lung carcinoma (NSCLC) and is less frequently inactivated in small cell lung carcinoma (SCLC) by mutation, deletion or DNA methylation.10339660
Colorectal Cancer PathwayEpigenetic AlterationsOur results suggest that deregulation of DNA methyltransferase gene expression does not play a role in establishing tumor-specific abnormal DNA methylation patterns in human colorectal cancer.10344733
Primary malignant neoplasmEpigenetic AlterationsAbnormal DNA methylation has been found to be a common feature in cancer cells, although the mechanism of this alteration remains poorly understood.10360376
Transitional cell carcinoma of kidneyEpigenetic AlterationsDNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas.10424731
NeoplasmsEpigenetic AlterationsSince DNA methylation is considered an important mechanism for silencing of retroelements in the mammalian genome, hypomethylation in human tumours may lead to their reactivation.10424731
Transitional cell carcinoma of ureterEpigenetic AlterationsThe coordinate changes of LINE-1 and HERV-K DNA methylation suggest that hypomethylation in urothelial cancer affects a variety of different retroelements to similar extents.10424731
Acquired Immunodeficiency SyndromeEpigenetic AlterationsIn addition to the effect of HIV-1 induced immune suppression, HIV may act directly as a co-factor for stimulation of JCV replication in AIDS patients, in part due to Tat-induced activation of JCV gene transcription.10602409
Pancreatic Neoplasm, Ductal CarcinomaEpigenetic AlterationsThese findings suggested that increased expression of sialyl Lewis antigens are involved in pancreatic tumorigenesis and that the accumulation of genetic alterations or epigenetic changes is responsible for the molecular mechanisms of increased expression of the sLe(a) and sLe(x) antigens in ductal carcinomas of pancreas.10606190
Hepatitis, Liver CirrhosisEpigenetic AlterationsAberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis.10680595
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsThe DNA methylation status of the region around the promoter of the E-cadherin tumor suppressor gene, which is located on 16q22.1, and the allelic status at the D16S421 locus, which is adjacent to the E-cadherin locus, were examined using microdissected liver specimens from 38 hepatocellular carcinoma (HCC) patients.10680595
HepatocarcinogenesisEpigenetic AlterationsThese data suggest that aberrant DNA methylation participates in the precancerous stage of hepatocarcinogenesis by preceding, or causing, LOH.10680595
Malignant Neoplasms, Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsWe report here that the pathogenesis of hepatocellular carcinoma (HCC), one of the most common cancers in the world, frequently involves an accumulation of somatic DNA methylation changes at GSTP1, the gene encoding the pi-class glutathione S-transferase.10717233
NeoplasmsEpigenetic AlterationsThe development of this technique should considerably enhance our ability to rapidly and accurately generate epigenetic profiles of tumor samples.10734209
Meningioma, NeoplasmsEpigenetic AlterationsDespite the high frequency of LOH at 1p32 microsatellite markers, the lack of genetic and epigenetic aberrations in the p18 gene together with the presence of p18 protein in all but one meningioma samples argues against the role of p18 as a tumour suppressor gene important for meningioma development.10736068
Adenoma of large intestineEpigenetic Alterations5,10-Methylene-tetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, may play a role in the etiology of colorectal adenomas via effects on DNA methylation and nucleotide synthesis.10744125
SF3B1 wt AlleleEpigenetic AlterationsAn unanswered question is whether p15INK4B gene methylation is restricted to undifferentiated blastic cells, or whether differentiated cells such as granulocytes or erythrocytes of MDS origin also harbor this epigenetic alteration.10764143
Breast CarcinomaEpigenetic AlterationsCpG island arrays: an application toward deciphering epigenetic signatures of breast cancer.10778974
Primary malignant neoplasmEpigenetic AlterationsCpG island hypermethylation is a frequent epigenetic event in cancer.10778974
Clinical Coordinator, High-Frequency Microsatellite Instability, Hereditary Nonpolyposis Colorectal Cancer, DNA Mismatch Repair Protein MSH2, humanEpigenetic AlterationsThe MSI-H phenotype, observed in both hereditary nonpolyposis colon cancer-associated CRC and approximately 15% of sporadic CRC, generally results from mutational or epigenetic inactivation of the DNA mismatch repair (MMR) genes hMSH2 or hMLH1.10786688
Colorectal NeoplasmsEpigenetic AlterationsThe enzyme 5,10-methylene-tetrahydrofolate reductase (MTHFR) may be linked to DNA methylation and nucleotide synthesis and thus play a role in the etiology of colorectal neoplasia.10794488
Admitting diagnosisEpigenetic AlterationsThese data establish that the association of Ckidelta with the tau pathology of AD is reflective of an increase in gene transcription.10814741
IGA GlomerulonephritisEpigenetic AlterationsAdrenomedullin gene transcription is decreased in peripheral blood mononuclear cells of patients with IgA nephropathy.10867534
NeoplasmsEpigenetic AlterationsHowever, the frequency of genetic and epigenetic inactivation of LKB1/STK11 in sporadic tumours is unclear.10896921
Squamous cell carcinomaEpigenetic AlterationsThe accumulation of ascorbic acid by squamous cell carcinomas of the lung and larynx is associated with global methylation of DNA.10897014
Metastasis, Liver carcinoma, InfiltrationEpigenetic AlterationsThe decrease of DNA methylation is present at the stage of liver carcinoma, and hypomethylation of c-myc, c-N-ras genes is correlated with the tendency of infiltration and metastasis.10920889
Malignant neoplasm of urinary bladder, Carcinoma of bladder, Carcinoma, Transitional CellEpigenetic AlterationsTo identify targets of genetic and epigenetic alterations on chromosome 11p15.5 in human bladder cancer, expression of the imprinted KIP2, IGF2 and H19 genes was studied by quantitative RT-PCR in 24 paired samples of urothelial carcinomas and morphologically normal mucosa obtained by cystectomy, and in bladder carcinoma cell lines.10944603
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe KIP2 gene could be an important target of genetic and epigenetic alterations in bladder cancer affecting the maternal chromosome 11p15.5.10944603
Malignant neoplasm of urinary bladderEpigenetic AlterationsGenetic and epigenetic alterations in normal bladder epithelium in patients with metachronous bladder cancer.10945601
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsTo see whether normal mucosa had already acquired genetic or epigenetic changes, we examined loss of heterozygosity (LOH) at 10 microsatellite loci and methylation of the p16(INK4) CpG island in multiple tumors and pathologically normal mucosa in six patients with bladder cancer.10945601
Malignant neoplasm of urinary bladderEpigenetic AlterationsThis result indicated that a population of cells in morphologically normal epithelium possessed genetic or epigenetic aberrations in common with bladder cancer, which might provide a ground for multiple tumorigenesis.10945601
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is an epigenetic feature of DNA that influences cellular development and function, and aberrations of DNA methylation are a candidate mechanism for the development of cancer.10952104
Primary malignant neoplasmEpigenetic AlterationsThe nuclear matrix-intermediate filament complex (NM-IF) is a protein scaffold which spans the whole cell, and several lines of evidence suggest that this structural frame represents also a functional unit, which could be involved in the epigenetic control of cancer development.10972984
CarcinogenesisEpigenetic AlterationsPrevious data support the hypothesis that abnormal DNA methylation plays an integral role in carcinogenesis.11010943
Malignant NeoplasmsEpigenetic AlterationsWe have previously shown malignancy is associated with increased DNA methylation in the 5 region of the PTHrP gene.11044652
Primary malignant neoplasmEpigenetic AlterationsAlthough demethylation may be a prerequisite for P2 and P3 expression, the overexpression of the PTHrP gene in cancer cells must be mediated through mechanisms other than DNA methylation.11044652
Transitional cell carcinoma of bladderEpigenetic AlterationsDNA methylation and the mechanisms of CDKN2A inactivation in transitional cell carcinoma of the urinary bladder.11045568
Hepatitis, Liver Cirrhosis, Liver carcinomaEpigenetic AlterationsGenetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma.11050047
Hepatocarcinogenesis, Loss of HeterozygosityEpigenetic AlterationsThe results of this study indicate that LOH and aberrant DNA methylation contribute to hepatocarcinogenesis; DNA hypermethylation in particular, which precedes or may even cause LOH, is as an early event during hepatocarcinogenesis.11050047
Prostate carcinomaEpigenetic AlterationsAlterations of DNA methylation are very frequent in prostatic carcinoma.11074524
Uterine CancerEpigenetic AlterationsAdditionally, there was no low DNA methylation in ER negative uterine cancer tissues.11083005
Prostate Cancer PathwayEpigenetic AlterationsBecause this epigenetic DNA alteration can be reliably detected by methylation-specific PCR (MSP), we applied this new technique for molecular detection of prostate cancer in various human bodily fluids.11085508
Malignant NeoplasmsEpigenetic AlterationsEpigenetic down-regulation of DAP-Kinase gene expression by hypermethylation of its promoter region was reported in B-cell malignancies.11092525
Colorectal Carcinoma, "cytidylyl-3-5-guanosineEpigenetic AlterationsDNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.11146446
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsAlterations in DNA methylation have been associated with cancers at almost all tumor sites and represent one of the most consistent changes in neoplastic cells.11205492
LymphomaEpigenetic AlterationsTaken together, an increased susceptibility for TNF gene transcription after LPS stimulation was observed in PBC (mainly in monocytes) from lymphoma patients, and especially those carrying the TNF2 allele.11274761
Prostate Cancer PathwayEpigenetic AlterationsEpigenetic regulation of human bone morphogenetic protein 6 gene expression in prostate cancer.11277266
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsOur results suggested that during cancer progression, besides inactivation of tumor suppressor genes by hypermethylation, activation of certain genes like BMP-6 by selective demethylation was a common epigenetic event giving a variable character to the invading and metastasizing cancer cells.11277266
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn a consecutive series of early stage non-small cell lung cancer (NSCLC), we have established the loss of expression of the G1 Cdk inhibitors p15INK4b) and p16INK4a by DNA methylation is very common (37%), and methylation of p16INK4a is tightly correlated with loss of expression of p16INK4a protein (P = 0.0018).11282426
Radiation-induced disorderEpigenetic AlterationsThe association might contribute, as an epigenetic and/or bystander effect, to development of several radiation-induced disorders.11304439
Anaplastic Oligodendroglioma, oligodendrogliomaEpigenetic AlterationsThe locus is deleted in up to 25% of oligodendrogliomas and 50% of anaplastic oligodendrogliomas, but little is known on the frequency of gene silencing by DNA methylation.11307615
Adenocarcinoma Of EsophagusEpigenetic AlterationsEpigenetic patterns in the progression of esophageal adenocarcinoma.11309301
NumerousEpigenetic AlterationsEach class undergoes unique epigenetic changes at different steps of disease progression of EAC, suggesting a step-wise loss of multiple protective barriers against CpG island hypermethylation.11309301
Malignant neoplasm of breastEpigenetic AlterationsEpigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.11333291
Malignant neoplasm of breast, NeoplasmsEpigenetic AlterationsRASSF1A is a potential tumor suppressor gene that undergoes epigenetic inactivation in lung and breast cancers through hypermethylation of its promoter region.11333291
Colorectal Cancer PathwayEpigenetic AlterationsHeterogeneity of DNA methylation status analyzed by bisulfite-PCR-SSCP and correlation with clinico-pathological characteristics in colorectal cancer.11341745
Carcinogenesis, NeoplasmsEpigenetic AlterationsAberrant DNA methylation has been identified as an important mechanism for inactivation of tumor suppressor genes and mismatch repair genes during carcinogenesis.11341745
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsMoreover, the degree of reduced DNA methylation was related to late histopathological HCC grade (P = 0.005) and large tumor size (P = 0.079).11358850
Squamous cell carcinoma of esophagusEpigenetic AlterationsBecause immunohistochemical study revealed that all of the ESCC samples showed loss of ING1 protein expression, genetic or epigenetic alterations that abrogate the normal function of ING1 may contribute to esophageal squamous cell carcinogenesis.11389058
Malignant NeoplasmsEpigenetic AlterationsSpecifically, genome-wide decreased DNA methylation (hypomethylation) in human cancers might be a consequence of decreased SAM levels.11406421
Stomach CarcinomaEpigenetic AlterationsThese results suggest that epigenetic changes in the hMLH1 promoter account for the genesis of multiple gastric carcinoma with high frequency MSI.11422806
ovarian neoplasmEpigenetic AlterationsThe expression of dMTase is a common feature of ovarian cancer and there is a correlation between dMTase and LRP expression, suggesting that there may be an epigenetic upregulation of the gene.11471858
NeoplasmsEpigenetic AlterationsThe epigenetic (nonhereditary) mechanism of hMLH1 promoter hypermethylation appears to be responsible for the majority of the remaining patients whose tumors are characterized by defective DNA MMR.11524701
ovarian neoplasmEpigenetic AlterationsDNA methylation and ovarian cancer.11531277
ovarian neoplasmEpigenetic AlterationsEpigenetic signatures in ovarian cancer were determined using DMH.11531277
Prostate Cancer PathwayEpigenetic AlterationsThis epigenetic DNA alteration served as the target for molecular detection of prostate cancer cells in urine sediments after prostatic massage.11549474
Adenocarcinoma Of EsophagusEpigenetic AlterationsThese data suggest that epigenetic silencing via aberrant methylation of the E-cadherin promoter is a common cause of inactivation of this gene in esophageal adenocarcinoma.11555590
Tumor necrosisEpigenetic AlterationsRecently, the mouse homologue of the tumor necrosis factor receptor superfamily 6 (TNFRSF6) gene was reported to be inactivated by DNA methylation in various cell types.11568974
CarcinomaEpigenetic AlterationsThus, although the TNFRSF6 gene can be inactivated efficiently by DNA methylation, hypermethylation occurs neither frequently nor extensively in human carcinomas and appears to play a limited role in downregulation of Fas expression.11568974
Primary malignant neoplasmEpigenetic AlterationsEpigenetic changes, including DNA methylation, are a common finding in cancer.11571631
Malignant neoplasm of lungEpigenetic AlterationsAlthough the importance of aberrant DNA methylation is well established, the extent of DNA methylation in lung cancers has never been determined.11571631
Mismatch Repair Deficiency, Hereditary Nonpolyposis Colorectal CancerEpigenetic AlterationsMicrosatellite instability is a hallmark of mismatch repair deficiency in hereditary nonpolyposis colorectal cancer and results from mutations in the mismatch repair genes MLH1 or MSH2 or from gene inactivation associated with DNA methylation.11601928
Stomach CarcinomaEpigenetic AlterationsWe hypothesized that loss of RARbeta in gastric cancer cells may occur as a result of multiple factors, including epigenetic modifications which alter RARbeta promoter chromatin structure.11683489
Nephroblastoma, Imprinting (Psychology)Epigenetic AlterationsLoss of imprinting (LOI) of the insulin-like growth factor-II (IGF2) gene, an epigenetic alteration associated with expression of the normally silent maternal allele, was observed first in Wilms tumor.11717330
Barrett Esophagus, Adenocarcinoma Of EsophagusEpigenetic AlterationsWe conclude that most Barretts metaplasia contains genetic and/or epigenetic p16 lesions and has the ability to undergo clonal expansion, creating a field in which other abnormalities can arise that can lead to esophageal adenocarcinoma.11719461
DNA Mismatch Repair Protein MSH2, human, MSH6 protein, humanEpigenetic AlterationsDefective DNA MMR results from genetic or epigenetic alterations that inactivate the DNA MMR genes hMLH1 or hMSH2, and rarely hMSH6.11753964
NCI CTEP SDC Oligodendroglial Tumors Sub-Category TerminologyEpigenetic AlterationsTaken together, our results indicate that hypermethylation of CDKN2A, p14ARF, and CDKN2B is an important epigenetic mechanism by which oligodendroglial tumors may escape from p53- and pRb-dependent growth control.11764089
Malignant NeoplasmsEpigenetic AlterationsWe attempted to identify tumor-related genes whose expression is affected by DNA methylation and that participate in the determination of the biological characteristics of human cancers.11768609
CarcinogenesisEpigenetic AlterationsRecent data suggest that such epigenetic abnormality may occur very early in lung carcinogenesis.11809677
Adenomatous Polyposis Coli, Primary Neoplasm, Carcinoma of lung, Gastrointestinal NeoplasmsEpigenetic AlterationsBecause genetic and epigenetic alterations of the adenomatous polyposis coli (APC) gene are common events in gastrointestinal tumor development, we sought to investigate the frequency and level of aberrant APC promoter methylation in primary tumors and paired preoperative serum or plasma samples of lung cancer patients by semiquantitative methylation-specific fluorogenic real-time PCR.11809682
Chronic Lymphocytic LeukemiaEpigenetic AlterationsTo elucidate the impact of this epigenetic mechanism on telomerase activity, we analyzed the degree of hTERT promoter methylation in 30 patients with B-cell chronic lymphocytic leukemia.11823034
Hepatocarcinogenesis, Hollings Cancer CenterEpigenetic AlterationsThis is a new type of predictive factor for HCC based on epigenetic changes in hepatocarcinogenesis, and in the future it is expected to be of great value in making preoperative diagnosis and selecting postoperative therapy.11850807
Adenocarcinoma of prostate, NeoplasmsEpigenetic AlterationsEpigenetic DNA alterations such as promoter hypermethylation of glutathione S-transferase P1 (GSTP1) in prostatic adenocarcinoma frequently constitute tumour biomarkers.11857497
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsA polymorphic variant (TT) has been linked to reduced levels of plasma folate, aberrant DNA methylation in leucocytes, and increased risk of colorectal cancer (CRC) under conditions of low folate intake.11889073
Clinical CoordinatorEpigenetic AlterationsThese variants may be involved in the development of the subgroup of CRC displaying aberrant DNA methylation and frequently associated with microsatellite instability (MSI).11889073
Oral Cavity CarcinomaEpigenetic AlterationsEpigenetic inactivation of 14-3-3 sigma in oral carcinoma: association with p16(INK4a) silencing and human papillomavirus negativity.11929827
CarcinogenesisEpigenetic AlterationsThese findings indicate that both genetic and epigenetic events occur independently in intratumor foci and further suggest hypermethylation-induced loss of gene function may be as critical as specific genetic mutations in prostate carcinogenesis.11943705
Colorectal NeoplasmsEpigenetic AlterationsMSI in sporadic colorectal tumours is primarily due to epigenetic silencing of MLH1.11948461
Carcinoma of lung, NeoplasmsEpigenetic AlterationsThe strong association seen between p16 methylation in the bronchial epithelium and corresponding primary tumor substantiates that inactivation of this gene, although not transforming by itself, is likely permissive for the acquisition of additional genetic and epigenetic changes leading to lung cancer.11956099
Colorectal Carcinoma, Colorectal Cancer Pathway, AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATEDEpigenetic AlterationsOur findings suggest that methylation in ACF is an early event in the pathogenesis of a subset of colorectal carcinomas, and that ACF from FAP patients and patients with sporadic colorectal cancer have distinct epigenetic changes that reflect differences in molecular pathogenesis.12000733
Prostate carcinomaEpigenetic AlterationsBecause GSTP1 promoter hypermethylation and inactivation of GSTpi expression is a frequent alteration in prostate carcinoma, we hypothesized that this somatic epigenetic modification could obviate any reduced enzyme activity caused by the germ-line polymorphism.12010858
AdenomaEpigenetic AlterationsHowever, menin might be involved in sporadic adenoma tumorigenesis by downregulation through intronic mutations, epigenetic, posttranscriptional or posttranslational mechanisms.12030908
Primary malignant neoplasmEpigenetic AlterationsCpG island methylation is an important mechanism in gene silencing and is a key epigenetic event in cancer development.12032849
NeoplasmsEpigenetic AlterationsThis study provides an important resource in the search for genes inactivated in tumors and for the investigation of epigenetic dysregulation of gene expression by CpG island methylation.12032849
Malignant NeoplasmsEpigenetic AlterationsIn general, >60% of serum from cancers with aberrant methylation demonstrated these epigenetic alterations.12060614
Acute lymphocytic leukemiaEpigenetic AlterationsDNA methylation patterns at relapse in adult acute lymphocytic leukemia.12060634
Acute leukemiaEpigenetic AlterationsAberrant DNA methylation of promoter-associated CpG islands is an epigenetic DNA modification observed in acute leukemias that in certain cases has been associated with a poor prognosis and increased relapse rates.12060634
Acute lymphocytic leukemiaEpigenetic AlterationsTo study the role of DNA methylation in relapse mechanisms in acute lymphocytic leukemia (ALL), we have compared the methylation status of five genes at the time of initial presentation and at first relapse in 25 adult patients with ALL.12060634
Acute lymphocytic leukemiaEpigenetic AlterationsIn summary, DNA methylation patterns are stable in a majority of patients with relapsed ALL, but a subset of patients acquire new methylation changes, in particular affecting cell cycle regulatory genes.12060634
Adenocarcinoma of lung (disorder)Epigenetic AlterationsClinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma.12114441
Adenocarcinoma of lung (disorder)Epigenetic AlterationsThese results indicated that epigenetic inactivation of RASSF1A plays an important role in the progression of lung adenocarcinoma, and that RASSF1A hypermethylation appears to be a useful molecular marker for the prognosis of patients with stage I lung adenocarcinoma.12114441
Endometrial NeoplasmsEpigenetic AlterationsIn patients with MSI positive EC, epigenetic inactivations rather than genetic mutations of the MMR genes seem to be involved in endometrial tumorigenesis.12115348
Endometrial CarcinomaEpigenetic AlterationsRibosomal DNA methylation in patients with endometrial carcinoma: an independent prognostic marker.12115383
Liver Cirrhosis, Hollings Cancer CenterEpigenetic AlterationsInactivation by DNA methylation of several genes of the RB1 pathway is common to cirrhosis and HCC.12143052
CarcinogenesisEpigenetic AlterationsThis means that a constitutive activation of antiapoptotic molecules via genetic or epigenetic mechanisms, including gene amplification, may well be involved in carcinogenesis.12208731
Discordance, SynesthesiaEpigenetic AlterationsWe suggest that the discordance in synaesthesia may be due to either an epigenetic event, X chromosome inactivation, or a mutation of a synaesthesia gene.12221147
Pulmonary Hypertension, Gaucher Disease, Type 3 (disorder)Epigenetic AlterationsPulmonary hypertension in type 1 Gauchers disease: genetic and epigenetic determinants of phenotype and response to therapy.12359135
Congenital absence of spleenEpigenetic AlterationsProgression to severe, life-threatening PH occurs in the presence of additional genetic factors (non-N370S GBA mutation, positive family history, and ACE I gene polymorphism) and epigenetic modifiers (i.e., asplenia and female sex).12359135
Primary malignant neoplasmEpigenetic AlterationsIn the cancer patients, no significant changes were found in TNF-RI and TNF-RII gene transcription, compared to the controls.12378118
Admitting diagnosis, Depression, CTCAEEpigenetic AlterationsCompared to controls and 354 background/alignment markers, AD brain showed a generalized depression in brain gene transcription, including decreases in RNA encoding transcription factors (TFs), neurotrophic factors, signaling elements involved in synaptic plasticity such as synaptophysin, metallothionein III, and metal regulatory factor-1.12391607
Non-Small Cell Lung CarcinomaEpigenetic AlterationsFrequent epigenetic silencing of the p16 gene in non-small cell lung cancers of tobacco smokers.12417040
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese findings suggest that tobacco smoking leads to inactivation of the p16 gene mainly through the epigenetic mechanism, ultimately increasing the risk of NSCLC, especially the squamous cell histological type.12417040
Hollings Cancer CenterEpigenetic AlterationsFurthermore, co-existence of methylated with unmethylated DNA in some cases suggested that both genetic and epigenetic (CpG methylation) mechanisms may act in concert to inactivate the p16INK4a and RASSF1a in HCC.12433278
CarcinogenesisEpigenetic AlterationsMethylenetetrahydrofolate reductase (MTHFR) plays a centralrole in converting folate to methyl donor for DNA methylation, an epigenetic modification known to be dysregulated in carcinogenesis.12433726
LINC01191 geneEpigenetic AlterationsEpigenetic silencing of p16(INK4a) was detected in 68% of VC, 69.2% of VIN, and 42.8% of LS cases.12454817
Carcinoma, S100A4 protein, human, LINC01191 geneEpigenetic AlterationsWe conclude (1) that p16(INK4a) epigenetic inactivation most likely represents an early event, insufficient for malignant transformation, that may occur in clinically benign lesions such as LS; (2) that lack of pRb was only detected in fewer than one quarter of the carcinomas and could be considered a late secondary event; and (3) that cyclin-D1, which was overexpressed in VC and VIN, could contribute to the malignant transformation in association with p16 hypermethylation.12454817
Lung NeoplasmsEpigenetic AlterationsDNA methylation profiles of lung tumors.12467239
NeoplasmsEpigenetic AlterationsThus, tumor cell lines appear to be suitable models to study aberrant DNA methylation.12467239
Prostate Cancer PathwayEpigenetic AlterationsIn prostate cancer, GSTP1 hypermethylation is the most common epigenetic alteration, and can be detected in up to 90% of cases.12499435
Non-Metastatic CarcinomaEpigenetic AlterationsBiallelic inactivation of hMLH1 by epigenetic silencing existed in human primary gastric carcinoma homogeneously.12508345
Primary malignant neoplasmEpigenetic AlterationsDNA methylation, an epigenetic modification, can result in loss of gene function in cancer, similar to genetic mutations such as deletions and point mutations.12525538
Primary Neoplasm, NeoplasmsEpigenetic AlterationsWe discuss two possible explanations for how different epigenetic events might arise between the primary tumour and the metastatic tumour of a person.12525538
Malignant NeoplasmsEpigenetic AlterationsThese results suggest that epigenetic inactivation of Chfr may be responsible for many of the checkpoint defects observed in human cancers.12538348
Aggressive behavior, Non-Small Cell Lung CarcinomaEpigenetic AlterationsThis epigenetic alteration is associated with inferior survival, suggesting that MGMT promoter hypermethylation might be an important biomarker for a biological aggressive disease in NSCLC.12538473
Alcoholic Liver DiseasesEpigenetic AlterationsGenetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease.12540792
Acute lymphocytic leukemiaEpigenetic AlterationsAberrant DNA methylation in pediatric patients with acute lymphocytic leukemia.12548613
Acute lymphocytic leukemiaEpigenetic AlterationsAberrant methylation of promoter-associated cystosine-guanine (CpG) islands is an epigenetic modification of DNA frequently observed in adult patients with acute lymphocytic leukemia (ALL).12548613
S100A4 protein, humanEpigenetic AlterationsThis epigenetic modification has been associated with gene silencing, malignant transformation, and aging.12548613
Acute lymphocytic leukemiaEpigenetic AlterationsIt is not known whether there are epigenetic differences between pediatric patients and adult patients with ALL.12548613
Primary malignant neoplasmEpigenetic AlterationsIt thus appears loss of allelic coordination is an epigenetic alteration characterizing cancer, which is easily identified by simple cytogenetic means and has a potential use in both cancer investigation and detection.12550768
Acute lymphocytic leukemiaEpigenetic AlterationsAberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia.12586619
Acute lymphocytic leukemiaEpigenetic AlterationsDNA methylation of a region surrounding the transcription start site of p57KIP2 was found in acute lymphocytic leukemia (ALL)-derived cell lines.12586619
Rectal CarcinomaEpigenetic AlterationsFindings provide limited support for an association between dietary factors involved in DNA methylation and risk of cancers of the colon and rectum.12588695
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsThis epigenetic inactivation mechanism remains elusive in hepatocellular carcinoma (HCC).12592365
NeoplasmsEpigenetic AlterationsThese data suggested that MGMT gene silencing in a subset of HCCs was likely caused by epigenetic alteration, such as promoter hypermethylation, and that the promoter hypermethylation silenced the hMLH1 gene in half of the hMLH1-negative tumours.12592365
Malignant Neoplasms, Carcinoma, Transitional CellEpigenetic AlterationsIn many common cancers such as transitional cell carcinoma (TCC), specific genes are hypermethylated, whereas overall DNA methylation is diminished.12594811
Suicidal behaviorEpigenetic AlterationsGiven the significance of CREB in mediating various physiological functions through gene transcription, our results of decreased expression and functional characteristics of CREB in postmortem brain of suicide subjects suggest that CREB may play an important role in suicidal behavior.12622660
Paroxysmal nocturnal hemoglobinuria, Aplastic AnemiaEpigenetic AlterationsThis epigenetic change is an additional feature shared by PNH and aplastic anemia.12623835
Traditional Serrated AdenomaEpigenetic AlterationsK-ras mutations in serrated adenomas may be unaffected by the epigenetic silencing of O6-methylguanine-DNA methyltransferase by promoter hypermethylation.12626907
Malignant NeoplasmsEpigenetic AlterationsAlteration of DNA methylation is one of the most consistent epigenetic changes in human cancers.12637155
Clinical Coordinator, Colorectal Cancer Pathway, Imprinting (Psychology)Epigenetic AlterationsLoss of imprinting (LOI), an epigenetic alteration affecting the insulin-like growth factor II gene (IGF2), is found in normal colonic mucosa of about 30% of colorectal cancer (CRC) patients, but it is found in only 10% of healthy individuals.12637750
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsWe performed a genetic and epigenetic study of the hMLH1 and hMSH2 mismatch repair genes in resected primary tumors from 77 non-small cell lung cancer (NSCLC) patients.12639995
CarcinogenesisEpigenetic AlterationsFolate metabolism is thought to play an important role in carcinogenesis through its involvement in both DNA methylation and nucleotide synthesis.12649184
Colorectal NeoplasmsEpigenetic AlterationsThese epigenetic changes were assessed in colorectal neoplasia to determine whether they arose through a common mechanism or indeed were distinct and unrelated phenomena.12651628
Primary central nervous system lymphoma, NeoplasmsEpigenetic AlterationsThese findings concur with previous data suggesting a frequent inactivation of p16(INK4A) and very limited involvement of TP53 in PCNSL and also provide insights into the epigenetic molecular involvement of other tumor-related genes in this neoplasm.12660028
Colorectal Carcinoma, AdenomaEpigenetic AlterationsGenetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma.12673484
Adenoma of large intestine, Colorectal Cancer PathwayEpigenetic AlterationsGenetic and epigenetic events encompassing APC occur variously among patients and tissues in sporadic colorectal cancer patients with synchronous colorectal adenoma.12673484
Adenomatous Polyposis Coli, Antigen-Presenting Cells, Carcinoma of lung, Primary NeoplasmEpigenetic AlterationsWe tested five gene promoters [CDKN2A (p16), O(6)-methylguanine-DNA-methyltransferase, glutathione S-transferase P1 (GSTP1), adenomatous polyposis coli (APC), and death-associated protein kinase (DAPK)] by real-time methylation-specific PCR in primary tumors from 90 stage I lung cancer patients for aberrant DNA methylation.12684406
Primary malignant neoplasmEpigenetic AlterationsPromoter hypermethylation is an important pathway for repression of gene transcription in cancer cells and a promising marker for cancer detection.12684406
Squamous cell carcinoma of esophagusEpigenetic AlterationsOur findings suggest that epigenetic silencing of RASSF1A gene expression by promoter hypermethylation could play an important role in primary esophageal squamous cell carcinogenesis.12684417
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsEpigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer.12684640
Carcinogenesis, NeoplasmsEpigenetic AlterationsEpigenetic events such as promoter-region gene hypermethylation may be influenced by environmental exposures and have been implicated in prostate carcinogenesis (by the silencing of tumor suppressors and other regulatory genes).12692786
CarcinogenesisEpigenetic AlterationsThese results suggest that inactivation of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 by epigenetic silencing does not seem to play a role in gastric carcinogenesis.12692836
Malignant neoplasm of endometriumEpigenetic Alterations[Estimation of DNA methylation level in endometrial cancer tissues].12722383
HyperplasiaEpigenetic AlterationsThere was no difference between DNA methylation level between normal endometrium and hyperplastic changes.12722383
Primary malignant neoplasmEpigenetic AlterationsThe field of epigenetics has seen a recent surge of interest among cancer researchers since alterations in DNA methylation have emerged as one of the most consistent molecular alterations in multiple neoplasms.12724234
Primary malignant neoplasmEpigenetic AlterationsEarly detection and risk assessment: proceedings and recommendations from the Workshop on Epigenetics in Cancer Prevention.12724234
Primary malignant neoplasmEpigenetic AlterationsIn the workshop the following areas of research were recognized for emphasis in future work: (1) basic epigenetic mechanisms in cancer need further investigation; (2) technology development in the area of epigenetics, such as high-throughput quantitative assays and increased sensitivity/specificity, is essential for the early detection and risk assessment of cancer; (3) the clinical application of epigenetic changes to cancer prevention and risk assessment needs further investigation.12724234
Primary malignant neoplasmEpigenetic AlterationsAn important distinction between genetic and epigenetic alterations in cancer prevention is that the latter might be more easily reversed using therapeutic interventions.12724234
Carcinoma of ampulla of Vater, Duodenal CancerEpigenetic AlterationsEpigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas.12730870
NeoplasmsEpigenetic AlterationsThe samples of primary tumor and paired lymph node metastatic tumor were collected and examined for aberrant gene promoter methylation in E-cadherin by DNA Methylation-specific polymerase chain reaction (MSP).12760799
HyperhomocysteinemiaEpigenetic AlterationsFolate therapy, a common method to reduce hyperhomocysteinaemia, restored DNA methylation to normal levels and corrected the patterns of gene expression.12767735
HyperhomocysteinemiaEpigenetic AlterationsOur results suggest that hyperhomocysteinaemia affects epigenetic control of gene expression, which can be reverted by folate treatment.12767735
Non-Small Cell Lung CarcinomaEpigenetic AlterationsEpigenetic silencing of RASSF1A is a frequent event in non-small lung cancer and will provide novel opportunities to develop diagnosis and therapy of NSCLC.12794755
Mammary Neoplasms, NeoplasmsEpigenetic AlterationsWe examined the DNA methylation status of the TMS1 promoter in lung and breast tumor tissues, tumor cell lines and nonmalignant tissues by methylation-specific polymerase chain reaction (MSP) and its mRNA expression by reverse transcription PCR.12800194
Malignant Neoplasms, AdenomaEpigenetic AlterationsUp-regulation of ALP56 gene transcription was observed in both adenomas and cancers compared to normal mucosa.12802606
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsSporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation.12810640
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsThese results indicate that SEMA3B gene alterations may play a important role in the malignant transformation of NSCLC via a two-hit mechanism, including epigenetic changes and allelic loss, for tumor suppressor gene inactivation.12810670
Prostate Cancer PathwayEpigenetic AlterationsWe have demonstrated the feasibility of a novel, noninvasive molecular approach for the detection of epigenetic changes associated with prostate cancer.12855646
Prostate Cancer PathwayEpigenetic AlterationsTreatment of prostate cancer cell lines with 5-aza-2-deoxycytidine (5-Aza-CdR), an inhibitor of DNA methylation, restored ZNF185 expression levels.12873976
Malignant Neoplasms, Myeloid Leukemia, Chronic, NeoplasmsEpigenetic AlterationsGeneral and site-specific DNA methylation is associated with tumor progression and resistance in several cancers, including chronic myelogenous leukemia (CML).12879469
SDHD wt AlleleEpigenetic AlterationsThese results suggest that the t(6;14) may represent a rare event in the pathogenesis of PGL and that cyclin D3 deregulation is most likely the result of epigenetic mechanisms.12898595
NeoplasmsEpigenetic AlterationsDNA methylation of some genes individually showed only trends toward diminished survival, whereas patients whose tumors had >50% of their gene profile methylated had both significantly poorer survival (P = 0.04) and earlier tumor recurrence (P = 0.05) than those without positive methylation.12912936
Carcinoma of lung, NeoplasmsEpigenetic AlterationsWe analysed 64 primary lung carcinomas for promoter methylation of the tumour suppressor genes (TSGs) p16 (p16(INK4a)/CDKN2A) and p14 (p14(ARF)) by methylation-specific PCR, in order to evaluate aberrant methylation as a potential biomarker for epigenetic alterations in tobacco-related lung cancer.12918069
Squamous cell carcinoma of the head and neckEpigenetic AlterationsEpigenetic silencing of the p16 and p15 genes by promoter methylation are commonly observed in human epithelial malignancies, including head and neck squamous cell carcinomas (HNSCC).12932666
Carcinogenesis, NeoplasmsEpigenetic AlterationsRecent studies suggest that tumor suppressor genes (TSGs) can also be silenced through epigenetic disruption, such as promoter CpG island methylation, during carcinogenesis.12937151
Malignant tumor of colonEpigenetic AlterationsGenetics supersedes epigenetics in colon cancer phenotype.12957287
Primary malignant neoplasmEpigenetic AlterationsCorrelation between protein expression and epigenetic and mutation changes of Wnt pathway-related genes in oral cancer.12963979
Malignant neoplasm of mouthEpigenetic AlterationsIn this study, we analyzed the epigenetic changes and expression patterns of four member proteins of the Wnt-signaling pathway and analyzed the mutations of beta-catenin and AXIN 1 genes, in order to explore the roles of the pathway in the development of oral cancer.12963979
Carcinoma of larynxEpigenetic AlterationsWe pose that RXRalpha overexpression might represent an early protective effect in the process of laryngeal carcinogenesis that might be overwhelmed by an epigenetic disability in forming heterodimers with PPARgamma.12969790
Pancreatic carcinoma, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsOur results indicate that maspin expression is up-regulated in most if not all pancreatic ductal adenocarcinomas and may be related to the development and differentiation, and that DNA methylation and histone deacetylation may suppress maspin gene activation in pancreatic cancer cells.12969792
Thyroid carcinomaEpigenetic AlterationsThese findings suggest that the infrequent development of thyroid carcinoma in MAS patients involves additional mutational or epigenetic events.12970318
Acute lymphocytic leukemiaEpigenetic AlterationsThe most common epigenetic lesion in childhood ALL was methylation of E-cadherin (72%) independent of the molecular subtype or other clinicopathological factors.12970785
Primary NeoplasmEpigenetic AlterationsGenetic and epigenetic alterations in sentinel lymph nodes metastatic lesions compared to their corresponding primary breast tumors.14499694
NeoplasmsEpigenetic AlterationsThe accumulation of genetic and epigenetic changes plays a pivotal role in tumor development and progression.14499694
Acute leukemiaEpigenetic AlterationsEpigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias.14513284
Breast CarcinomaEpigenetic Alterationsp16 and/or CDH1 hypermethylation was found in 31% (11/36) of primary breast carcinomas and 82% (9/11) of breast cancer patients with tumoral methylation showing identical epigenetic changes in plasma.14534701
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation is an important biologic event in colorectal cancer and in some cases is associated with the development of microsatellite instability (MSI).14551292
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsDNA methylation is associated with a worse outcome in colorectal cancer, but this adverse prognostic influence is lost in those methylated tumors showing MSI.14551292
DU-PAN-2Epigenetic AlterationsAdditionally, there was a good correlation between BETA;3GAL-T5 gene transcription levels and immunohistochemical grades of CA 19-9 or its precursor DUPAN-2 in cancerous tissues.14555842
Malignant neoplasm of prostateEpigenetic AlterationsWe investigated the epigenetic silencing of Cyclin D2 gene in prostate cancers and correlated the data with clinicopathological features.14581343
NeoplasmsEpigenetic AlterationsAlthough considerable work has been done on the epigenetic control of tumor suppressor genes, little is known about the potential role of promoter CpG demethylation in the activation of oncogenes.14612939
NeoplasmsEpigenetic AlterationsFor some tumour suppressor genes, epigenetic silencing is a more common mechanism of inactivation than somatic mutations.14627671
Clinical Coordinator, Refractory Cytopenia of Childhood, carmustine/dacarbazine/hydroxyureaEpigenetic AlterationsHowever, we did not detect evidence of epigenetic silencing of BHD in 19 CRC and RCC cell lines, and BHD promoter region hypermethylation was not detected in 20 primary RCCs.14627671
Breast CarcinomaEpigenetic AlterationsDNA methylation in serum of breast cancer patients: an independent prognostic marker.14633683
Neoplastic diseaseEpigenetic AlterationsChanges in the status of DNA methylation are one of the most common molecular alterations in human neoplasia.14633683
Breast CarcinomaEpigenetic AlterationsBecause it is possible to detect these epigenetic alterations in the bloodstream of patients, we investigated whether aberrant DNA methylation in patient pretherapeutic sera is of prognostic significance in breast cancer.14633683
Primary malignant neoplasmEpigenetic AlterationsUsing MethyLight, a high-throughput DNA methylation assay, we analyzed 39 genes in a gene evaluation set, consisting of 10 sera from metastasized patients, 26 patients with primary breast cancer, and 10 control patients.14633683
Breast CarcinomaEpigenetic AlterationsDNA methylation of particular genes in pretherapeutic sera of breast cancer patients, especially of RASSF1A/APC, is more powerful than standard prognostic parameters.14633683
Malignant NeoplasmsEpigenetic AlterationsDNA methylation is a key regulator of gene transcription and genomic stability, and alteration of DNA methylation is one of the most consistent epigenetic changes in human cancers.14634451
Nasopharyngeal carcinomaEpigenetic AlterationsEpigenetic inactivation of TSLC1 gene in nasopharyngeal carcinoma.14639656
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsFrequent epigenetic inactivation of TSLC1 gene in NPC suggested that this gene is one of the target tumor suppressor genes of this endemic cancer.14639656
Metastatic malignant neoplasm to brainEpigenetic AlterationsOur data suggest an important role for gene methylation in the development of brain metastases, primarily involving epigenetic silencing of DAP-kinase, THBS1 and the cell-cycle regulators RB1/p16INK4a.14654977
Behavior of tumor, Gastrointestinal Stromal Tumors, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe growing understanding of the epigenetic changes associated with cancer, including aberrant promoter methylation of tumor suppressor genes that afford selective growth advantages to human neoplasms, suggests that the characterization of gene methylation patterns among gastrointestinal stromal tumors (GISTs) may be useful for predicting tumor behavior.14675710
Colorectal CarcinomaEpigenetic AlterationsAberrant DNA methylation occurs in a subset of colorectal cancers and is characterized by regional areas of hypermethylation at CpG islands.14676107
Kidney Failure, Acute, NeoplasmsEpigenetic AlterationsTumors with aberrant DNA methylation of CpG islands within promoter regions of the hMLH1, TIMP3, and ARF genes also contained higher levels of both 5,10-methylenetetrahydrofolate and FH4.14676107
RestenosisEpigenetic AlterationsThese findings suggest the genetic contribution to stent restenosis and support the notion that the long dinucleotide GT repeat in promotor region may interfere with HO-1 gene transcription, leading to decreased vascular protection upon injury.14683741
Childhood MedulloblastomaEpigenetic AlterationsIdentification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.14688019
Childhood Medulloblastoma, NeoplasmsEpigenetic AlterationsTo assess the role of aberrant epigenetic events in medulloblastoma and identify critical genes in its development, we profiled the promoter methylation status of 11 candidate tumour-suppressor genes (TSGs; p14(ARF), p15(INK4b), p16(INK4a), CASP8, HIC1, EDNRB, TIMP3, TP73, TSLC1, RIZ1 and RASSF1A) in medulloblastoma cell lines, primary tumours and the normal cerebellum.14688019
Childhood MedulloblastomaEpigenetic AlterationsMoreover, methylation of these genes in medulloblastoma cell lines was associated with their epigenetic transcriptional silencing and methylation-dependent re-expression following treatment with the DNA methyltransferase inhibitor, 5-aza-2-deoxycytidine.14688019
Childhood MedulloblastomaEpigenetic AlterationsWe conclude that epigenetic TSG inactivation is a significant feature of medulloblastoma, and identify RASSF1A, HIC1 and CASP8 as potentially critical genes in its pathogenesis.14688019
Primary malignant neoplasmEpigenetic AlterationsOur results indicate that epigenetic alteration of these genes is a frequent event in oral cancer, and is an early event observed in normal oral mucosa of the patients, indicating the critical importance of the epigenetic alteration in chewing tobacco associated oral carcinogenesis.14693237
Malignant neoplasm of urinary bladderEpigenetic AlterationsOur results indicate that maspin may contribute to bladder cancer development and that DNA methylation and histone deacetylation may be important for regulating maspin gene activation in bladder cancer cells.14732229
NeoplasmsEpigenetic AlterationsWe have recently documented that the ATM promoter is a target for epigenetic silencing in cultured tumor cells.14744748
Leukemia, Myelocytic, AcuteEpigenetic AlterationsSequencing FANCA in the AML samples with FANCA deletions did not detect mutations in the second allele and there was no evidence of epigenetic silencing by hypermethylation.14749703
Squamous cell carcinomaEpigenetic AlterationsGenetic and epigenetic alterations of the blood group ABO gene in oral squamous cell carcinoma.14750174
cervical cancer, NeoplasmsEpigenetic AlterationsDNA methylation in serum and tumors of cervical cancer patients.14760078
DNA Mismatch Repair Protein MSH2, humanEpigenetic AlterationsDefective DNA mismatch repair results from genetic or epigenetic alterations that most frequently inactivate the genes hMLH1 and hMSH2.14760534
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsTo analyze the genetic and epigenetic alterations of RUNX3 gene, a potential putative tumor suppressor gene, in hepatocellular carcinoma (HCC).14760761
Acute leukemiaEpigenetic AlterationsEpigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias.14762685
NeoplasmsEpigenetic AlterationsDifferential expression of ER-alpha and ER-beta may alter the expression of key target genes (such as those induced by AP-1-dependent gene transcription), and contribute to the pathogenesis and clinical behavior of these tumors.14766247
ovarian neoplasm, QPCT gene, NeoplasmsEpigenetic AlterationsOur results, therefore, suggest a potential role for epigenetic modification of these critical tumour suppressor genes in pathways relevant to the transformation and differentiation of rare type of ovarian cancer (GCTs).14970867
Multiple MyelomaEpigenetic AlterationsSOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway.14976049
Multiple MyelomaEpigenetic AlterationsThe role of promoter hypermethylation leading to epigenetic inactivation of SOCS1 and SHP1 in myeloma was investigated.14976049
Multiple MyelomaEpigenetic AlterationsSHP1 methylation leading to epigenetic activation of the Jak/STAT pathway might have a tentative role in the pathogenesis of myeloma, which should be further confirmed by functional studies in primary myeloma samples.14976049
PheochromocytomaEpigenetic AlterationsGenetic and epigenetic profile of sporadic pheochromocytomas.14985401
Colorectal Cancer Pathway, Imprinting (Psychology)Epigenetic AlterationsLoss of imprinting (LOI) of insulin-like growth factor-II (IGF-II) may be an inherited epigenetic trait that is polymorphic in the population, and its presence may predispose an individual to the development of colorectal cancer.14996863
Colorectal Cancer PathwayEpigenetic AlterationsOur findings support the hypothesis that LOI of IGF-II is an epigenetic trait polymorphic in the population and suggest that LOI of IGF-II may play a role in colorectal cancer.14996863
Stomach CarcinomaEpigenetic AlterationsCDH1 promoter hypermethylation was found in 20 out of 70 gastric carcinomas and the epigenetic change occurred in the early, as well as in the locally advanced disease.14998854
Unknown (origin) (qualifier value)Epigenetic AlterationsSimilar decreases in T cell DNA methylation occur in idiopathic lupus, potentially contributing to disease pathogenesis.15004168
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsRecent data implicate HP in the pathogenesis of colorectal cancers (CRC) characterised by extensive DNA methylation and microsatellite instability.15016754
NeoplasmsEpigenetic AlterationsDNA methylation was tested in methylated in tumour (MINT) loci (1, 2, 12, 31) and genes HPP1, MGMT, p14ARF, p16INK4a, and hMLH1.15016754
Prostate Cancer PathwayEpigenetic AlterationsAberrant DNA methylation patterns may be the earliest somatic genome changes in prostate cancer.15026333
Retinitis PigmentosaEpigenetic AlterationsTo avoid inaccurate risk assessment for RP due to epigenetic events, such as the rare occurrence of germ line mosaicism, genetic counseling in families with XLRP should always be guided by molecular testing.15032968
NeoplasmsEpigenetic AlterationsTherefore, DNA methylation pattern might be a useful tool to give a primary diagnosis of a brain tumor or as a marker for the early detection of the relapse of the disease.15037658
NeoplasmsEpigenetic AlterationsA simple epigenetic method for the diagnosis and classification of brain tumors.15037658
Bile duct carcinomaEpigenetic AlterationshTERT gene transcription and protein expression is most likely involved in the proliferation and malignant transformation of bile epithelia and the malignant progression of bile duct carcinomas.15059327
Chronic Lymphocytic LeukemiaEpigenetic AlterationsEpigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets.15059895
CarcinogenesisEpigenetic AlterationsIdentification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning.15059896
Malignant NeoplasmsEpigenetic AlterationsThis methylation screening strategy should identify additional genes inactivated by epigenetic silencing in colorectal and other cancers.15059896
NeoplasmsEpigenetic AlterationsThis data strongly supports the hypothesis that overexpression of transdominant p73 isoforms can function as epigenetic inhibitors of p53 in vivo, thereby alleviating selection pressure for p53 mutations in tumors.15059898
Multiple malignancyEpigenetic AlterationsGermline epimutation of MLH1 in individuals with multiple cancers.15064764
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsWe hypothesized that an epimutation could occur in any gene as a germline event that predisposes to disease and looked for examples in tumor suppressor genes in individuals with cancer.15064764
Embryonic MosaicEpigenetic AlterationsThe mosaicism and nonmendelian inheritance that are characteristic of epigenetic states could produce patterns of disease risk that resemble those of polygenic or complex traits.15064764
CarcinogenesisEpigenetic AlterationsThese results suggest that inactivation of the ATP2A2 gene is a frequent and early event during oral carcinogenesis and that loss of expression may be regulated partly by an epigenetic mechanism.15069686
Pancreatic carcinomaEpigenetic AlterationsIn conclusion, the marked over-expression of 14-3-3sigma in PADC together with multiple known genetic and epigenetic alterations of potential 14-3-3sigma interacting partners suggests an important role of aberrant 14-3-3sigma downstream signaling in pancreatic cancer.15073049
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe development and application of these new genetic and epigenetic markers with high specificity and sensitivity for PCa in serum and PJ will significantly improve our diagnostic accuracy.15084968
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation is a common molecular alteration in colorectal cancer cells.15094274
Colorectal Cancer PathwayEpigenetic AlterationsWhether a combination of genetic and epigenetic markers will identify colorectal cancer at an early stage remains to be shown.15094274
Carcinoma, Ovarian EpithelialEpigenetic AlterationsDecreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation.15102672
ovarian neoplasmEpigenetic AlterationsOur findings suggest that 14-3-3 sigma is inactivated mainly by aberrant DNA methylation and that it may play an important role in the pathogenesis of epithelial ovarian cancer.15102672
Primary Malignant Liver Neoplasm, NeoplasmsEpigenetic AlterationsThe p53 tumor suppressor gene is known to play an important role in carcinogenesis of different tissues being involved in gene transcription, DNA synthesis and repair and somatic mutations of p53 are common in primary liver cancer.15105048
ArteriosclerosisEpigenetic AlterationsTaken together, our results unequivocally show that alterations in DNA methylation profiles are early markers of atherosclerosis in a mouse model and may play a causative role in atherogenesis.15131116
Behavior, Ameloblastic CarcinomaEpigenetic AlterationsWe conclude that other genetic or epigenetic mechanisms may be responsible for malignant behavior in ameloblastic carcinomas.15133474
Clinical CoordinatorEpigenetic AlterationsIn this study, 67 sporadic CRC and eight samples of normal bowel were analysed for MSI status (by SSCP) and levels of MLH1, MSH2 and p53 gene transcription (by RT-PCR and scanning densitometry).15138486
Pancreatic carcinoma, Aggressive behaviorEpigenetic AlterationsPancreatic cancer is an aggressive malignancy that exhibits a number of genetic and epigenetic alterations.15146555
cervical cancerEpigenetic AlterationsA DNA methylation pattern similar to normal tissue is associated with better prognosis in human cervical cancer.15159026
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsInterestingly, statistically significantly less patients whose tumor DNA methylation pattern clustered together with normal cervical tissue died within our observation period, as compared to those patients out of the three remaining clusters (P < 0.03) Cervical cancer patients, whose DNA methylation pattern clustered together with normal cervical tissue revealed a strong trend to better survival (P = 0.066) compared to patients grouped in the remaining cluster.15159026
Acute lymphocytic leukemia, Lymphoma, Large-Cell, FollicularEpigenetic AlterationsThese data are in accordance with the hypothesis that polymorphisms in the genes for folate and methionine metabolism might play a greater role in the occurrence of ALL than NHL by influencing DNA synthesis and/or DNA methylation.15159311
Colorectal Cancer PathwayEpigenetic AlterationsFurther study is needed focusing on ethnic variations in the relationships among MTHFR polymorphism, DNA methylation and the development of CIMP(+) colorectal cancer.15161007
cervical cancerEpigenetic AlterationsFurthermore, the epigenetic regulation of p73 expression via DNA methylation was also investigated in 103 cervical cancers and 124 normals.15161684
Malignant neoplasm of lungEpigenetic AlterationsIn this study, we report for the first time reduced expression of the let-7 microRNA in human lung cancers.15172979
Malignant neoplasm of lungEpigenetic AlterationsReduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival.15172979
cervical cancerEpigenetic AlterationsContribution of epigenetic risk factors but not p53 codon 72 polymorphism to the development of cervical cancer in Northeastern Thailand.15183536
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsO6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma.15184253
Lupus ErythematosusEpigenetic AlterationsOverexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors.15188362
Lupus Erythematosus, SystemicEpigenetic AlterationsWe then determined whether CD70 is overexpressed on T cells treated with other DNA methylation inhibitors and on SLE T cells, and determined its functional significance.15188362
Lupus Erythematosus, SystemicEpigenetic AlterationsSLE T cells and T cells treated with DNA methylation inhibitors overexpressed CD70 and overstimulated B cell IgG production.15188362
GammopathyEpigenetic AlterationsDNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.15197802
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers.15201980
Malignant neoplasm of kidney, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTo gain insight into the role of epigenetic silencing of tumor suppressor and cancer genes in kidney tumorigenesis, we determined a hypermethylation profile of kidney cancer.15217927
melanomaEpigenetic AlterationsPE SLNs (n = 308) from these patients were sectioned and assessed by qRT for mRNA of four melanoma-associated genes: MART-1 (antigen recognized by T cells-1), MAGE-A3 (melanoma antigen gene-A3 family), GalNAc-T (beta1-->4-N-acetylgalactosaminyl-transferase), and Pax3 (paired-box homeotic gene transcription factor 3).15226334
Malignant neoplasm of breastEpigenetic AlterationsThe CDH13/Sat2 epigenetic correlation was seen also in breast cancers.15231656
Serrated intestinal polyps, Rectal CarcinomaEpigenetic AlterationsBRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum.15247181
Clinical CoordinatorEpigenetic AlterationsThe BRAF mutation was frequently seen in SSA and in sporadic MSI-H CRC, both of which were associated with DNA methylation.15247181
Malignant Neoplasms, AdenomaEpigenetic AlterationsSporadic MSI-H cancers may originate in SSA and not adenomas, and BRAF mutation and DNA methylation are early events in this "serrated" pathway.15247181
Breast CarcinomaEpigenetic AlterationsAlthough the number of samples was relatively small, our results suggest that DNA methylation in ERalpha and ERbeta are present in breast cancer tissue, and that the methylation causes a significant effect on transcriptional silencing.15254780
Non-Small Cell Lung CarcinomaEpigenetic AlterationsUsing genetic and epigenetic analyses, we examined various molecular alterations including the loss of protein and mRNA expression, and 5CpG hypermethylation, allelic imbalance, and mutation of the p14ARF gene in a series of 102 NSCLC samples, in parallel with clinicopathological and prognostic analyses.15269146
Malignant neoplasm of kidneyEpigenetic AlterationsWe investigated the feasibility of detecting aberrant DNA methylation in the urine and serum samples of renal cancer patients.15289362
NeoplasmsEpigenetic AlterationsThere were no significant correlations between DNA methylation in tumor, margins, or bronchoalveolar fluid specimens and either regional recurrence or distant metastases.15297416
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsWe hypothesized that DNA promoter hypermethylation changes at bronchial margins could be detected in patients with no histological evidence of malignancy and that they would reflect epigenetic events in the primary tumor.15297416
NeoplasmsEpigenetic AlterationsConcordance of one gene with an identical epigenetic change in the tumor or bronchial margin was observed in 85% of patients.15297416
Malignant NeoplasmsEpigenetic AlterationsThese results suggest that loss of function of HELLS/SMARCA6 by allelic loss and aberrant proteins by tumor-specific exon creation may result in epigenetic deregulation, leading lung cells to malignancy or its progression.15305370
NeoplasmsEpigenetic AlterationsOur data suggest that the t(6;14) translocation may be extremely uncommon in FL and that a deregulated expression of cyclin D3, possibly due to epigenetic mechanisms, may be involved in the pathogenesis of high-grade tumors.15305377
Multiple MyelomaEpigenetic AlterationsDNA methylation changes in multiple myeloma.15318245
Squamous cell carcinoma, Adenocarcinoma, Non-Small Cell Lung CarcinomaEpigenetic AlterationsDNA methylation analysis of the proximal promoter region of this gene revealed abnormal hypermethylation in 67% of the adenocarcinomas and 50% of squamous cell carcinomas, indicating that epigenetic mechanisms are involved in silencing this gene in NSCLC.15328519
NeoplasmsEpigenetic AlterationsDNA methylation patterns in the CpG island of the MGMT gene were determined in every tumor by methylation specific PCR (MSP).15332332
Squamous cell carcinoma of esophagusEpigenetic AlterationsEpigenetic mechanism might be associated with reduced expression of FHIT in a part of ESCC cases.15363189
MeningiomaEpigenetic AlterationsDNA methylation of multiple promoter-associated CpG islands in meningiomas: relationship with the allelic status at 1p and 22q.15365725
MeningiomaEpigenetic AlterationsThe purpose of this research was to examine the DNA methylation profile of meningiomas.15365725
Meningioma, NeoplasmsEpigenetic AlterationsOur findings indicate that aberrant DNA methylation of promoter-associated CpG islands in meningiomas contributes to the development of these tumors.15365725
MeningiomaEpigenetic AlterationsThese meningiomas primarily accumulated the epigenetic changes of THBS1 (14/30; 47%; P < 0.005), TIMP-3 (12/30; 40%; P < 0.05), p73 (10/30; 26%; P < 0.02) and p14(ARF) /p16(INK4a)(7/30 each one; 23%; not significant).15365725
Antigen-Presenting CellsEpigenetic AlterationsWe found a clear change in the expression level of the gene transcription product of APC in canceration of oral squamous epithelium and the differentiation of oral SCC.15380172
Primary malignant neoplasmEpigenetic AlterationsGene promoter hypermethylation is increasingly recognized to play an important role in cancer development through silencing of gene transcription.15386372
Breast CarcinomaEpigenetic AlterationsA number of different genes are known to be inactivated by aberrant hypermethylation in breast cancer, but it is still unknown to what extent these epigenetic alterations differ according to specific breast cancer phenotypes.15447983
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAberrant methylation of 5 gene promoter regions is an epigenetic phenomenon that is a major mechanism for silencing of tumor suppressor genes in many cancer types.15447999
Colorectal Cancer PathwayEpigenetic AlterationsAlthough the mutator phenotype, including genetic and epigenetic alterations of the mismatch repair (MMR) system, seems to be pronounced in familial colorectal cancer, there have been few integrative studies comprising the entire mutator pathway.15448003
Neoplastic disease, Primary malignant neoplasmEpigenetic AlterationsThe genetic and epigenetic alterations that initiate and drive cancer can be used as targets for detection of neoplasia in bodily fluids.15448006
Malignant NeoplasmsEpigenetic AlterationsPromoter hypermethylation of CpG islands in tumor-related genes can lead to their transcriptional inactivation, and this epigenetic mechanism has been shown to participate in MGMT silencing in some cancers, including those affecting the nervous system.15450401
teratologic, NeoplasmsEpigenetic AlterationsAccordingly, a link between both genetic and epigenetic anomalies may exist in these neoplasms.15450401
Primary malignant neoplasmEpigenetic AlterationsEpigenetic silencing of O(6)-methylguanine-DNA methyltransferase (MGMT) by promoter methylation can confer cancer cells with an increased sensitivity to alkylating chemotherapeutic agents and a higher susceptibility to TP53 transition mutations.15455376
Carcinoma of lungEpigenetic AlterationsAnthracotic index and DNA methylation status of sputum contents can be used for identifying the population at risk of lung carcinoma.15481085
Carcinogenesis, NeoplasmsEpigenetic AlterationsThe investigations on the role of DNA methylation in carcinogenesis have been mainly focused on promoter hypermethylation of tumor suppressor genes.15487509
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsAs a number of genes associated with cancer development may be influenced by DNA methylation, identification of these genes is of great importance for understanding the epigenetic alteration in carcinogenesis.15487509
Carcinoma of lungEpigenetic AlterationsThe hypermethylated DNA fragments identified in this study might be specific epigenetic alterations in the Chinese lung cancer.15487509
NeoplasmsEpigenetic AlterationsEpigenetic silencing of multiple genes seen in some tumors is at best rarely the result of an inherited defect in the methylation apparatus.15492290
MICROPHTHALMIA, SYNDROMIC 7Epigenetic AlterationsMethylation of E-cadherin and RARbeta occurs preferentially in AMLs with high methylation index (MI), while epigenetic lesions in SOCS1, DAP-kinase, and p15 appear to be independent.15495254
Colorectal Cancer PathwayEpigenetic AlterationsDetection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study.15502094
Myeloid Leukemia, ChronicEpigenetic AlterationsIn chronic forms of CML, no strong correlations among the level of histone methylation, disease progression, and modality of treatment were observed.15507473
Myeloid LeukemiaEpigenetic AlterationsMethylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities.15507473
Liver carcinomaEpigenetic AlterationsWe provide evidence indicating that epigenetic mechanisms, involving DNA methylation and histone deacetylation, may play a role in the silencing of MTAP gene expression in hepatocarcinoma.15511635
Stomach CarcinomaEpigenetic AlterationsThe up-regulation of proto-oncogene may be the consequence of epigenetic control of gene expression by demethylase, and mbd2 is involved in the regulation of hMSH2 expression in human gastric cancer.15526354
Carcinoma of lungEpigenetic AlterationsPolymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer.15528220
Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation.15542810
CarcinogenesisEpigenetic AlterationsChanges in DNA methylation can be detected with a high degree of sensitivity, so we used the MethyLight assay to determine how methylation patterns of apoptosis-associated genes change during bladder carcinogenesis and whether DNA methylation could be detected in urine sediments.15569975
Primary malignant neoplasmEpigenetic AlterationsThere is increasing evidence for a fundamental role for epigenetic silencing of apoptotic pathways in cancer.15569975
Colorectal CarcinomaEpigenetic AlterationsEpigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis.15569977
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsThe epigenetic inactivation of ID4 gene on colorectal cancer (CRC) development and its clinical significance was assessed.15569977
Hepatocarcinogenesis, NeoplasmsEpigenetic AlterationsThe tumor suppressor gene p16INK4A is mainly inactivated by an epigenetic change involving promoter hypermethylation in hepatocarcinogenesis.15569978
Carcinoma of lungEpigenetic AlterationsThese epigenetic changes in the GATA genes in lung cancer are tumor-specific, relate to the loss of GATA gene expression, and occur increasingly in the elderly.15585625
CarcinogenesisEpigenetic AlterationsWe elucidated the significance of aberrant DNA methylation on pericentromeric satellite regions during urothelial carcinogenesis.15592089
RhabdomyosarcomaEpigenetic AlterationsIn addition to exemplifying developmental dysregulation, methylation of PAX3 has potential in the development of an epigenetic profile for the diagnosis of rhabdomyosarcoma.15602708
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsEpigenetic alteration, via promoter hypermethylation, inactivates genes important for the development of head and neck squamous cell carcinoma (SCCHN).15635575
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, NeoplasmsEpigenetic AlterationsTo detect epigenetic changes in head and neck squamous cell carcinoma (HNSCC) and between metastatic and nonmetastatic tumors, we performed a systematic phosphorylation screening on different protein kinases.15641106
CarcinogenesisEpigenetic AlterationsEpigenetic events such as promoter hypermethylation have been implicated in prostate carcinogenesis.15649863
Alcoholic Intoxication, ChronicEpigenetic AlterationsWe observed a significant increase of the alpha synuclein promoter DNA methylation in patients with alcoholism which was significantly associated with their elevated homocysteine levels.15671870
NeoplasmsEpigenetic AlterationsIn contrast, this epigenetic modification was shown in only three of 23 tumours in which no decrease in TFPI-2 synthesis was found (P=0.016).15685245
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese results show that epigenetic inactivation of RASSF1A cannot be a prognostic marker of NSCLC.15700308
Fecal occult blood test, AdenomaEpigenetic AlterationsWe explored the potential of a single epigenetic marker in comparison with fecal occult blood testing (FOBT) for the discrimination of patients with CRCs and adenomas from those without.15704048
AdenomaEpigenetic AlterationsWe postulate that a panel of merely a few genetic and epigenetic markers will be required for the highly sensitive and specific detection of CRCs and adenomas in fecal samples from affected patients.15704048
Malignant NeoplasmsEpigenetic AlterationsDNA methylation of CRBP1, MINT31 or CDH13 was not correlated between cancers and ACF from the same patients.15704093
Malignant neoplasm of liver, Loss of HeterozygosityEpigenetic AlterationsAllele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors.15704097
Carcinoma of lung, NeoplasmsEpigenetic AlterationsPreviously, the RASSF1A, BLU and SEMAPHORIN 3B (SEMA3B) candidate tumor suppressor genes on chromosome 3p21.3 were found to be inactivated and downregulated by genetic and epigenetic changes in lung cancer.15704097
Malignant neoplasm of liverEpigenetic AlterationsIn conclusion, our data indicate that 2-hit gene silencing of SEMA3B through epigenetic changes and allele loss is a common and important event in the carcinogenesis of malignant liver tumors.15704097
Carcinoma of lungEpigenetic AlterationsIdentification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer.15709192
Malignant Neoplasms, CarcinogenesisEpigenetic AlterationsDNA methylation changes are an early event in carcinogenesis and are often present in the precursor lesions of various cancers.15713962
cervical cancer, Cervical Intraepithelial NeoplasiaEpigenetic AlterationsWe examined whether DNA methylation changes might be used as markers of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC).15713962
Nasopharyngeal carcinomaEpigenetic AlterationsEpigenetic silencing of cellular retinol-binding proteins in nasopharyngeal carcinoma.15720818
Nasopharyngeal carcinomaEpigenetic AlterationsRecently, we have demonstrated frequent epigenetic inactivation of a retinoic acid receptor (RAR), RARbeta2, in nasopharyngeal carcinoma (NPC).15720818
Primary malignant neoplasmEpigenetic AlterationsOur findings implied that epigenetic disruption of the CRBPs, CRBPI and CRBPIV, is important in NPC tumorigenesis and may contribute to the loss of retinoic acid responsiveness in cancer.15720818
Malignant NeoplasmsEpigenetic AlterationsEmerging evidence suggests that microRNA, which are well-conserved, abundant and small regulatory RNA, may be involved in the pathogenesis of human cancers.15723655
Breast CarcinomaEpigenetic AlterationsWe analyzed RASSF1A DNA methylation in pretherapeutic sera and serum samples collected 1 year after surgery from 148 patients with breast cancer who were receiving adjuvant tamoxifen; 19.6% and 22.3% of patients with breast cancer showed RASSF1A DNA methylation in their pretherapeutic and 1-year-after serum samples, respectively.15734995
Malignant Neoplasms, Hollings Cancer CenterEpigenetic AlterationsIn addition to their known epigenetic or genetic abnormality in malignancies, these findings suggest that altered transcription of these two imprinted genes contributes to progression of HCC.15736456
Non-Small Cell Lung CarcinomaEpigenetic AlterationsFrequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.15746151
SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsAberrant DNA methylation is frequently observed in adults with myelodysplastic syndrome (MDS), and is recognized as a critical event in the diseases pathogenesis and progression.15755284
NeoplasmsEpigenetic AlterationsWe previously identified apolipoprotein D (Apo D) as a novel tumor suppressor gene based on the pharmacological unmasking of epigenetic silencing.15756681
NeoplasmsEpigenetic AlterationsIn addition, tumors with an advanced pathological stage showed epigenetic alteration of the RAS association domain family 1A promoter with a higher frequency.15758578
Carcinoma of lungEpigenetic AlterationsDetection of epigenetic alterations in serum may provide basis for the early and noninvasive lung cancer diagnosis and customized therapy.15758578
Malignant NeoplasmsEpigenetic AlterationsAberrant methylation of DNA has been shown to play an important role in a variety of human cancers, developmental disorders and aging.15760842
Clinical Coordinator, Carcinogenesis, Colorectal CarcinomaEpigenetic AlterationsA distinctive pathway of colorectal carcinogenesis termed CpG island methylator phenotype is characterized by extensive DNA methylation in colorectal carcinoma (CRC) cells but not in nonneoplastic mucosa.15767794
Hereditary hemorrhagic telangiectasia, EpistaxisEpigenetic AlterationsEpistaxis in hereditary hemorrhagic telangiectasia (HHT; Rendu-Osler-Weber syndrome) is a frequent symptom that may be caused by a multitude of different genetic and epigenetic phenomena.15794077
Cartilaginous exostosis, Chondrosarcoma, Exostosin-2Epigenetic AlterationsTo evaluate promoter methylation (which is an epigenetic gene silencing mechanism) of EXT1 and EXT2, we performed methylation-specific polymerase chain reaction (PCR) for 20 chondrosarcoma cases (12 primary, 3 secondary to osteochondroma, 2 secondary to enchondromatosis, 2 extraskeletal ordinary, and 1 clear cell) and in five cell lines.15796962
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThis is the first time that the significance of p53 promoter methylation status is described in this pathology, and our data support that this epigenetic phenomenon could be involved in the pathogenesis and clinical evolution of CLL.15801955
Colorectal CarcinomaEpigenetic AlterationsGenetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability.15802015
Admitting diagnosisEpigenetic AlterationsIn order to address transcriptional changes associated with this selective vulnerability, we used subtractive hybridization of transcripts derived from human frontal cortex, which degenerates in late stages of AD, against transcripts of the inferior temporal cortex, which is affected both heavily and early in the course of AD.15813938
Hollings Cancer CenterEpigenetic AlterationsThese data suggest that PAP expression designate a subset of low-grade, low-stage HCC with frequent beta-catenin mutation and hence more favorable prognosis, whereas further genetic or epigenetic alterations, such as p53 mutation and REG1A expression, lead to more advanced HCCs.15814635
Adenoma of large intestineEpigenetic AlterationsEffect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma.15831910
Adenoma of large intestineEpigenetic AlterationsThe hypothesis that folic acid supplementation increases DNA methylation in leucocytes and colorectal mucosa was tested in 31 patients with histologically confirmed colorectal adenoma using a randomised, double blind, placebo controlled, parallel design.15831910
Acute lymphocytic leukemiaEpigenetic AlterationsTo study the relationship between protein expression and DNA methylation of a triad of cell-cycle regulatory genes known to be frequently methylated in adult acute lymphocytic leukemia (ALL).15851765
cervical cancerEpigenetic AlterationsThis phase I study evaluated the tolerability and its effects upon DNA methylation and gene reactivation in patients with untreated cervical cancer.15862127
NeoplasmsEpigenetic AlterationsHydralazine at doses between 50 and 150 mg/day is well tolerated and effective to demethylate and reactivate the expression of tumor suppressor genes without affecting global DNA methylation.15862127
Rett SyndromeEpigenetic AlterationsThis observation adds another dimension to the epigenetic factors that may contribute to the phenotype in RTT.15862188
Breast CarcinomaEpigenetic AlterationsThus, down-regulation of the HIVEP2 genes frequently occurs and may be one of the genetic events responsible for breast cancer, and their transcription may be regulated by complex mechanisms involving interactions with other factors and/or by other genetic/epigenetic mechanisms.15868437
CarcinogenesisEpigenetic AlterationsVitamin B6, whose main circulating form is pyridoxal 5-phosphate (PLP), is important in one-carbon metabolism, which is critical for DNA synthesis and DNA methylation, both of which are potentially involved in colorectal carcinogenesis.15870439
Gastric Adenocarcinoma, PGC gene, "Barretts Adenocarcinoma", Best Case Imputation TechniqueEpigenetic AlterationsAlthough the incidence of Barretts carcinomas (BC) and proximal gastric adenocarcinomas (PGC) is increasing, little is known about different epigenetic changes in these etiopathogenetically distinct entities.15870861
NeoplasmsEpigenetic AlterationsThis is the first report on promoter methylation of death-associated protein kinase (DAPK) and fragile histidine triad gene (FHIT) in BC; both DAPK (BC 0.7, JC 0.92 and PGC 0.86) and FHIT (BC 0.88, JC 1.0 and PGC 1.0) were found to be highly methylated, suggesting that epigenetic silencing of these tumor suppressors is a common event in adenocarcinomas of the upper gastrointestinal tract, including BC.15870861
NeoplasmsEpigenetic AlterationsThis might constitute an early epigenetic precursor lesion in the normally-appearing tissue surrounding the tumor.15870861
NeoplasmsEpigenetic AlterationsRealization that many tumor suppressor genes are silenced by epigenetic mechanisms has stimulated the discovery of novel tumor suppressor genes.15886297
NeoplasmsEpigenetic AlterationsThe Ras-association domain family 1A (RASSF1A) tumour suppressor gene is inactivated in a variety of solid tumours, usually by epigenetic silencing of the promoter and/or allelic loss of its locus at 3p21.3.15887288
Glaucoma, Primary Open AngleEpigenetic AlterationsTAP1-1 and TAP1-2 gene polymorphisms may, by way of post-transcriptional changes and altered regulation of gene expression, be involve the immune system in the development of POAG.15887980
SarcomaEpigenetic AlterationsGenetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas.15891996
Malignant NeoplasmsEpigenetic AlterationsHypermethylation of promoter CpG islands is a common epigenetic event in a variety of human cancers.15892004
MeningiomaEpigenetic AlterationsIn conclusion, this study demonstrates that aberrant hypermethylation profile is associated with atypical and anaplastic meningiomas, suggesting that epigenetic change may be involved in malignant progression of meningiomas.15892004
Lymphoma, T-Cell, Cutaneous, NeoplasmsEpigenetic AlterationsEpigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73.15897551
TSPYL2 wt Allele, Lymphoma, T-Cell, CutaneousEpigenetic AlterationsTo analyze the occurrence of promoter hypermethylation in primary cutaneous T-cell lymphoma (CTCL) on a genome-wide scale, focusing on epigenetic alterations with pathogenetic significance.15897551
Breast CarcinomaEpigenetic AlterationsAssociation of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer.15899800
Breast CarcinomaEpigenetic AlterationsDNA methylation in the promoter regions of genes is a prominent epigenetic gene silencing mechanism that contributes to breast cancer biology.15899800
Breast Carcinoma, NeoplasmsEpigenetic AlterationsUsing a microarray-based technology, the promoter DNA methylation status of 117 candidate genes was studied in a cohort of 200 steroid hormone receptor-positive tumors of patients who received the antiestrogen tamoxifen as first-line treatment for recurrent breast cancer.15899800
CarcinogenesisEpigenetic AlterationsGene silencing due to aberrant DNA methylation plays an important role in carcinogenesis.15911243
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMethylation of several CpG islands was frequently found in normal lung tissue of cancer patients and this may have been attributed to epigenetic field defect and/or infiltrating tumour cells.15911247
Neoplasms, Biliary Tract CancerEpigenetic AlterationsTumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers.15915369
Liver and Intrahepatic Biliary Tract CarcinomaEpigenetic AlterationsThus, we examined epigenetic (promoter methylation) and genetic (gene mutation) alterations in biliary tract cancer.15915369
Liver and Intrahepatic Biliary Tract CarcinomaEpigenetic AlterationsReduced MGMT expression may increase the malignant potential of biliary tract cancer through both epigenetic and genetic mechanisms.15915369
Carcinoma of lung, NeoplasmsEpigenetic AlterationsOur results showed that, while candidate tumor suppressor genes at this locus can be simultaneously inactivated by epigenetic alterations, loss of heterozygosity without any hypermethylation of the three genes can also occur in some cases, suggesting that just one allelic loss might also be sufficient for the inactivation of any of these genes for lung cancer development.15922865
Gastrointestinal Stromal TumorsEpigenetic AlterationsIt is noteworthy that, in all of the methylated GISTs, the epigenetic promoter alteration was coupled with mRNA expression.15929122
Stomach CarcinomaEpigenetic AlterationsThese results suggest that the detection of DNA methylation in the serum may carry both diagnostic and therapeutic values in gastric cancer patients.15942635
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAberrant DNA methylation is a frequent phenomenon in non-small cell lung cancers.15942649
Squamous cell carcinoma, AdenocarcinomaEpigenetic AlterationsThe highest degree of differential DNA methylation in squamous cell carcinoma compared to normal was observed in ARHI, MGMT, GP1bbeta, RARbeta and TMEFF2 genes, while TMEFF2, MGMT and CDKNIC genes differentiated between adenocarcinomas and normal tissue.15942649
NeoplasmsEpigenetic AlterationsOf the 60 tumors, DNA methylation of the p16(INK4a) promoter was detected in 28 tumors (47%); the respective values DNA methylation of the RASSF1A, DAPK, and MGMT promoters were 25 tumors (42%), 16 tumors (27%), and 4 tumors (7%), respectively.15959912
NeoplasmsEpigenetic AlterationsForty-six tumors (77%) had DNA methylation in > or = 1 of the 4 promoters, 20 tumors (33%) had DNA methylation in > or = 2 promoters, 6 tumors (10%) had DNA methylation in > or = 3 promoters, and 1 tumor (2%) had DNA methylation in all 4 promoters.15959912
SERPINB3 wt AlleleEpigenetic AlterationsOur results suggest that DNA methylation of multiple genes, especially hypermethylation of the p14ARF promoter, is common in OSCC and is associated with the use of tobacco and/or alcohol consumption.15975525
Acute lymphocytic leukemiaEpigenetic AlterationsAberrant DNA methylation of a cell cycle regulatory pathway composed of P73, P15 and P57KIP2 is a rare event in children with acute lymphocytic leukemia.15978938
Acute lymphocytic leukemiaEpigenetic AlterationsAberrant DNA methylation of multiple promoter associated CpG islands is a frequent phenomenon in acute lymphocytic leukemia (ALL).15978938
Acute lymphocytic leukemiaEpigenetic AlterationsThese results indicate that differences in DNA methylation of specific molecular pathways may contribute to the prognostic differences known to occur between pediatric and adult patients with ALL.15978938
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsWe, therefore, examined, in a population-based study of human bladder cancer, the relationship between epigenetic silencing of three tumor suppressor genes, p16(INK4A), RASSF1A and PRSS3, and exposure to both tobacco and arsenic in bladder cancer.15987713
Bladder NeoplasmEpigenetic AlterationsThese results, from human bladder tumors, add to the body of animal and in vitro evidence that suggests a role in epigenetic alterations for bladder carcinogens.15987713
SchizophreniaEpigenetic AlterationsThe association of a specific epigenetic mark, H3-(methyl)-lysine 4, with the molecular architecture of glutamatergic signaling in human brain has potential implications for schizophrenia and other disorders with altered glutamate receptor function.15998284
ovarian neoplasmEpigenetic AlterationsWe analyzed the DNA methylation status and mRNA expression of p15INK4b and p16INK4a in 52 ovarian cancer specimens and 40 normal ovarian specimens by using methylation-specific PCR and real-time reverse transcription-PCR, respectively.16000597
Carcinogenesis, ovarian neoplasmEpigenetic AlterationsOur results suggest that epigenetic alterations in p15INK4b but not p16INK4a have an important role in ovarian carcinogenesis and that mechanisms other than methylation may exist to reduce gene expression of p15INK4b in ovarian cancer.16000597
cervical cancer, NeoplasmsEpigenetic AlterationsHistone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer.16001982
Primary malignant neoplasmEpigenetic AlterationsThe development of cancer has been associated with epigenetic alterations such as aberrant histone deacetylase (HDAC) activity.16001982
CarcinogenesisEpigenetic AlterationsWe conclude that epigenetic inactivation of the PTGIS gene is a recurrent alteration in colorectal carcinogenesis.16007128
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic silencing of the PRSS3 putative tumor suppressor gene in non-small cell lung cancer.16013053
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAs epigenetic alteration is common in non-small cell lung cancer (NSCLC), we sought to determine if promoter hypermethylation of PRSS3 occurred in this disease, and if it was associated with clinical features of NSCLC or tobacco-related exposures in these patients.16013053
Hereditary nonpolyposis colorectal carcinoma, Colorectal CarcinomaEpigenetic AlterationsThe current data showed instead that the BRAF V599E mutation was associated only with a subgroup of colorectal carcinomas with MSI that were obtained from older patients without hereditary nonpolyposis colorectal carcinoma and showed epigenetic silencing of hMLH1.16015629
NeoplasmsEpigenetic AlterationsThese results indicated that tumors with MSI caused by epigenetic MLH1 silencing have a distinct mutational background from that of tumors with genetic loss of mismatch repair, suggesting that there are two genetically distinct entities of microsatellite-instable tumors.16015629
Head and Neck CarcinomaEpigenetic AlterationsDNA methylation in the CTCF-binding site I and the expression pattern of the H19 gene: does positive expression predict poor prognosis in early stage head and neck carcinomas?16015666
Calcibiotic Root Canal SealerEpigenetic AlterationsAlthough extensive methylation of CpG islands within the promoter regions of DNA mismatch repair genes such as MLH1 is thought to play a central role in tumorigenesis for MSI-positive sporadic CRCs, it has been obscure whether such aberrant epigenetic regulation occurs more widely and affects other cancer-related genes in vivo.16033773
CarcinogenesisEpigenetic AlterationsCommon polymorphisms at the MTHFR nucleotides position 677 (C-T) and a 28-bp tandem repeat polymorphism (2R or 3R) in the TS promoter enhancer region (TSER) have been reported to be functional and are supposed to disturb the normal DNA methylation and synthesis leading to carcinogenesis.16045580
CarcinogenesisEpigenetic AlterationsOne-carbon metabolism, in which folate plays an essential role, is involved in DNA methylation and synthesis, and is suspected of impacting on colorectal carcinogenesis.16051637
CarcinogenesisEpigenetic AlterationsAberrant DNA methylation has been shown to play an important role during multistage carcinogenesis in various human organs.16053511
CarcinogenesisEpigenetic AlterationsEpigenetic events, especially those involving alterations in the breast stromal microenvironment, may play an important role in radiation-induced carcinogenesis but remain not well understood.16061655
Epithelioma, CarcinogenesisEpigenetic AlterationsThe aim of this study was to compare the promoter hypermethylation profiles of ovarian epithelial neoplasms to better understand the role of epigenetic silencing in carcinogenesis.16061849
Malignant neoplasm of ovaryEpigenetic AlterationsPromoter hypermethylation is a frequent epigenetic event that occurs most commonly in invasive epithelial ovarian carcinomas.16061849
Non-Small Cell Lung Carcinoma, LossEpigenetic AlterationsIn NSCLC, loss of PTEN protein expression occurs frequently, although the mechanism responsible for loss is not clearly attributable to deletion or epigenetic silencing.16084946
Malignant neoplasm of urinary bladderEpigenetic AlterationsEpigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer.16103055
Malignant neoplasm of urinary bladderEpigenetic AlterationsUsing a population-based study of bladder cancer (n = 355), we examined epigenetic alterations, specifically gene promoter hypermethylation, of four SFRP genes in addition to immunohistochemical staining of TP53, which has been previously shown to be a predictor of invasive disease.16103055
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAberrant methylation of 5gene promoter regions associated with gene silencing is an epigenetic phenomenon responsible for silencing of tumor suppressor genes in many cancer types.16108009
CarcinogenesisEpigenetic AlterationsRecent data suggest that epigenetic abnormalities may occur very early in lung carcinogenesis.16129599
Stomach CarcinomaEpigenetic AlterationsDNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation.16134180
CarcinogenesisEpigenetic AlterationsThe results suggested that gastric carcinogenesis involves transcriptional inactivation by aberrant DNA methylation of genes related to retinoid signaling.16134180
Malignant Neoplasms, MetastasisEpigenetic AlterationsLoss of epigenetic control of synuclein-gamma gene as a molecular indicator of metastasis in a wide range of human cancers.16140929
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsBy performing genomic sequencing and methylation-specific PCR assays, we identify an inclusive demethylation of CpG sites within the CpG island of SNCG gene in every tumor sample (100%) across all cancer types, illustrating a universal loss of the epigenetic control of SNCG gene expression in tumors and further demonstrating that the demethylation of SNCG CpG island is primarily responsible for the aberrant expression of SNCG protein in cancerous tissues.16140929
Malignant neoplasm of ovaryEpigenetic AlterationsThese data suggest that genetic and epigenetic changes might lead to elevated cytoplasmic expression of BARD1 and that cytoplasmic BARD1 might be a poor prognostic factor for breast and ovarian cancers.16152612
NeoplasmsEpigenetic AlterationsPromoter genomic DNA methylation is an important inactivation mechanism of tumor suppressor genes.16163424
Blood Circulation, Colorectal Cancer PathwayEpigenetic AlterationsWhile promoter hypermethylation is a common molecular alteration of human colorectal cancer that could be detected in the bloodstream, we tested the feasibility of quantitative detection of aberrant DNA methylation in multiple genes in the serum samples of colorectal cancer patients.16181380
Colorectal Cancer PathwayEpigenetic AlterationsThe quantitative detection of aberrant DNA methylation in serum may be a promising high-throughput approach for the noninvasive screening and monitoring of colorectal cancer.16181380
NeoplasmsEpigenetic AlterationsThis observation suggested that tumors from these patients might be more prone to DNA deletion events; consistent with this, epigenetic silencing of the DNA double-strand break repair genes FancF and BRCA1 was also associated with homozygous deletion of p16(INK4a)(p = 0.002 and p = 0.06, respectively).16184554
Acute lymphocytic leukemiaEpigenetic AlterationsChildhood and adult ALL: differences in epigenetic lesions associated with cell cycle genes.16184585
Arteriosclerosis, Primary malignant neoplasmEpigenetic AlterationsSince DNA methylation is an important epigenetic factor in the regulation of gene expression, alteration of the methylation pattern has been associated with aging, cancer, atherosclerosis and other diseases.16197315
S-AdenosylhomocysteineEpigenetic AlterationsIn conclusion, an inhibitory effect of SAH on whole-genome methylation was found, but from our data no interaction between vegetarian lifestyle and DNA methylation could be determined.16197315
Degenerative polyarthritisEpigenetic AlterationsThis study provides the first evidence that altered synthesis of cartilage-degrading enzymes by late-stage OA chondrocytes may have resulted from epigenetic changes in the methylation status of CpG sites in the promoter regions of these enzymes.16200590
Malignant Neoplasms, HereditaryEpigenetic AlterationsSporadic MSI+ cancers may require more than a single additional somatic alteration compared to hereditary MSI+ cancers because the epigenetic inactivation of MLH1 commonly observed in sporadic MSI+ cancers may be a multistep process.16202134
ovarian neoplasmEpigenetic AlterationsCpG island methylation of DNA damage response genes in advanced ovarian cancer.16204069
Primary malignant neoplasmEpigenetic AlterationsWe have examined the frequency of a polymorphism in the DNA methyltransferase gene DNMT3b6, which has been previously reported to affect gene transcription and cancer risk.16204069
Secondary malignant neoplasm of liver, Carcinogenesis, Colorectal CarcinomaEpigenetic AlterationsIn summary, we observed frequent TPEF methylation in primary colorectal cancers and liver metastases, indicating that epigenetic alterations are not only present in the early phases of carcinogenesis, but are also common in metastatic lesions.16207479
Colorectal Carcinoma, Primary malignant neoplasmEpigenetic AlterationsThe high frequency of TPEF methylation in this series of colorectal cancers underscores the importance of epigenetic changes as targets for the development of molecular tests for cancer diagnosis.16207479
Squamous cell carcinoma of esophagusEpigenetic AlterationsAberrant p16 methylation, a possible epigenetic risk factor in familial esophageal squamous cell carcinoma.16227635
Primary malignant neoplasmEpigenetic AlterationsThe inactivation of checkpoint genes by genetic and epigenetic mechanisms is frequent in all cancer types, as a less-efficient cell cycle control can lead to genetic instability and tumorigenesis.16230422
Leukemia, Myelocytic, AcuteEpigenetic AlterationsClinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia.16231140
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAberrant DNA methylation was found in AML of all French-American-British subtypes and throughout all cytogenetic risk groups.16231140
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe growing knowledge of the role of epigenetics in the aberrant silencing of cancer-related genes provides a rationale and molecular basis for targeted therapeutic approaches with demethylating agents in AML.16231140
Malignant - descriptorEpigenetic AlterationsThe accumulation of epigenetic events affecting genes which are involved in regulating cell cycle inhibition, cell adhesion, growth factor signaling, and apoptosis may contribute to the malignant AML phenotype.16231140
Malignant NeoplasmsEpigenetic AlterationsDNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers.16234815
Primary malignant neoplasmEpigenetic AlterationsThe loss of DRM/Gremlin mRNA expression in human cancer cell lines is associated with DNA methylation, and treatment with the methylation inhibitor-reactivated mRNA expression (n=13).16234815
PYCARD gene, Primary malignant neoplasmEpigenetic AlterationsWe checked the methylation status of 20 cancer associated genes (p14ARF, p16 CDKN2A, STAT-1, SOCS-1, DR-3, DR-6, PIG-7, BCL-2, H-TERT, BAX, EDNRB, DAPK, RASSF-1A, FADD, TMS-1, E-Cadherin, ICAM-1, TIMP-3, MLH-1, COX-2) for DNA methylation.16242928
Malignant neoplasm of urinary bladderEpigenetic AlterationsThere is increasing evidence for the role of epigenetic gene silencing in superficial bladder cancer.16242928
Colorectal CarcinomaEpigenetic AlterationsEpigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability.16247484
Colorectal CarcinomaEpigenetic AlterationsMutation or epigenetic silencing of mismatch repair genes, such as MLH1 and MSH2, results in microsatellite instability (MSI) in the genome of a subset of colorectal carcinomas (CRCs).16247484
CarcinogenesisEpigenetic AlterationsThese data indicate that epigenetic silencing of AXIN2 is specifically associated with carcinogenesis in MSI+ CRCs.16247484
Adenocarcinoma of lung (disorder)Epigenetic AlterationsDNA methylation status of CpG islands seems to be a useful predictor of long-term outcome for adenocarcinoma of the lung.16256792
Metastasis, Neuroendocrine TumorsEpigenetic AlterationsEpigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis.16258509
Primary malignant neoplasmEpigenetic AlterationsSince aging increases promoter hypermethylation and epigenetic silencing of HIC1, we speculate that the resultant upregulation of SIRT1 may be a double-edged sword that both promotes survival of aging cells and increases cancer risk in mammals.16269335
CarcinogenesisEpigenetic AlterationsAlthough there is growing interest in the possibility that alterations in histone methylation may play a role in carcinogenesis, it has not been explored adequately in humans.16276009
Non-Cancer Related DeathEpigenetic AlterationsCorrelations between DNA and histone methylation, H_3-Lys4 and H_3-Lys9 were positive and statistically significant in all tissue types; they were strongest in normal oral epithelium from non-cancer subjects (r=0.63, p < 0.001 and r=0.62, p < 0.001 respectively).16276009
CarcinogenesisEpigenetic AlterationsPatterns of DNA and histone methylation are similar in tissues across the spectrum of oral carcinogenesis, and there is a significant positive association between these two epigenetic mechanisms.16276009
Hereditary Nonpolyposis Colorectal CancerEpigenetic AlterationsMLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer.16285940
MLH1 geneEpigenetic AlterationsGermline MLH1 epimutations are functionally equivalent to an inactivating mutation and produce a clinical phenotype that resembles HNPCC.16285940
NeoplasmsEpigenetic AlterationsGermline epimutations should be suspected in younger individuals without a family history who present with a microsatellite unstable tumor showing loss of MLH1 expression.16285940
Malignant NeoplasmsEpigenetic AlterationsCurrent evidence suggests that hypermethylation of promoter CpG islands is a common epigenetic event in a variety of human cancers.16311119
CarcinogenesisEpigenetic AlterationsEpigenetic silencing through DNA methylation is one of the key steps during carcinogenesis.16314833
Stomach CarcinomaEpigenetic AlterationsFrequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas.16314833
HSPD1 geneEpigenetic AlterationsHsp60 was expressed on the plasma membrane of heat-stressed ECs, and this followed Hsp60 messenger RNA transcription, confinement of the protein to the cytoplasm, and translocation of the protein to the surface.16320351
Colorectal CarcinomaEpigenetic AlterationsDiffering DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries.16322286
Prostate Cancer PathwayEpigenetic AlterationsTo analyze the prognostic significance of six epigenetic biomarkers (APC, Cyclin D2, GSTP1, TIG1, Rassf1A, and RARbeta2 promoter hypermethylation) in a homogeneous group of prostate cancer patients, following radical prostatectomy alone.16322291
Liver CirrhosisEpigenetic AlterationsA comparison of CH and liver cirrhosis samples revealed significantly different pattern of miRNA expression (P<0.01).16331254
Hollings Cancer CenterEpigenetic AlterationsWhereas three miRNAs exhibited higher expression in the HCC samples than that in the NT samples, five miRNAs demonstrated lower expression in the HCC samples than in the NT samples (P<0.0001).16331254
Hollings Cancer CenterEpigenetic AlterationsIn addition, the expression levels of four miRNAs were inversely correlated with the degree of HCC differentiation (P<0.01).16331254
Prostate Cancer PathwayEpigenetic AlterationsAlthough many genetic events have been described to be involved in androgen-dependent and/or -independent prostate cancer growth, little is known about the contribution of epigenetic events.16331274
Hollings Cancer CenterEpigenetic AlterationsThe frequent loss of transcription of p16INK4a with promoter methylation not only in the advanced but also in the early stages of HCC suggests that the epigenetic alteration of p16INK4a promoter is likely to be involved in hepatocarcinogenesis.16343074
Stage I Esophageal Squamous Cell Carcinoma AJCC v7Epigenetic AlterationsMetallothionien 3 expression is frequently down-regulated in oesophageal squamous cell carcinoma by DNA methylation.16351731
Colorectal Cancer PathwayEpigenetic AlterationsGiven that, DNA methylation is a common event in colorectal cancer.16352895
Neurofibromatosis 2, MeningiomaEpigenetic AlterationsLack of genetic and epigenetic changes in meningiomas without NF2 loss.16353169
Neurofibromatosis 2, Meningioma, NeoplasmsEpigenetic AlterationsTo gain more insight into the aetiology of these tumours, we studied genetic and epigenetic alterations in 25 meningiomas without NF2 involvement.16353169
Meningioma, NeoplasmsEpigenetic AlterationsIn conclusion, meningiomas with an intact NF2 gene have a normal karyotype and no obvious genetic or epigenetic aberrations, suggesting that the gene(s) involved in the pathogenesis of these tumours are altered by smaller events than can be detected with the techniques used in our study.16353169
Breast Cancer CellEpigenetic AlterationsEpigenetic mechanisms underlying tumorigenesis have recently received much attention as potential therapeutic targets of human cancer.16357841
Blood Clot, Primary malignant neoplasmEpigenetic AlterationsFolate deficiency is associated with increased risk for thrombosis, as well as for several types of cancer, through disruption of DNA methylation, DNA synthesis and deficient DNA repair.16365753
melanoma, NeoplasmsEpigenetic AlterationsEpigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma.16374457
melanoma, NeoplasmsEpigenetic AlterationsOur findings suggest that epigenetic silencing of the studied tumor suppressor genes is a common and probably important mechanism for melanoma formation.16374457
MucinousEpigenetic AlterationsThe more frequent occurrence and closer association among MSI, CIMP and BRAF mutation in mucinous CRC observed in our study further supports the idea that its pathogenesis may involve distinct genetic and epigenetic changes.16381005
NeoplasmsEpigenetic AlterationsTumors with BRAF mutation were also 10-fold more likely to show microsatellite instability and frequent DNA methylation (P < 0.0001) compared to tumors without this mutation.16403224
NeoplasmsEpigenetic AlterationsIn addition, downregulation of both CEP63 and EIF4G2 gene transcription was associated with invasive tumors.16410684
Primary malignant neoplasm, Inflammation, Somatic mutationEpigenetic AlterationsPotential molecular and physiologic contributors to the frequency of cancer occurrence in older individuals include the accumulation of somatic mutations through defects in genome maintenance, epigenetic gene silencing, oxidative stress, loss of immune surveillance, telomere dysfunction, chronic inflammation, and alterations in tissue microenvironment.16424011
Pancreatic DiseasesEpigenetic AlterationsDNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease.16424060
CarcinogenesisEpigenetic AlterationsDNA hypermethylation in gene promoters is an epigenetic mechanism regulating gene expression in cellular immortalization, an important step in carcinogenesis.16426144
Malignant neoplasm of urinary bladderEpigenetic AlterationsEpigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway.16428476
Bladder NeoplasmEpigenetic AlterationsTo test this hypothesis, epigenetic and genetic pathways involved in the Wif-1 gene modulation and expression of Wnt/beta-catenin-related genes were analyzed in 4 bladder tumor cell lines and 54 bladder tumor and matched normal bladder mucosa.16428476
Carcinogenesis, Prostatic Intraepithelial NeoplasiasEpigenetic AlterationsEpigenetic heterogeneity of high-grade prostatic intraepithelial neoplasia: clues for clonal progression in prostate carcinogenesis.16446401
NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumour suppressor genes through promoter methylation has been investigated by a variety of means, the most recent of which is pyrosequencing.16449996
Renal Cell CarcinomaEpigenetic AlterationsThe recurrence-free survival rate of patients with RCCs showing accumulation of DNA methylation was significantly lower than that of patients not showing this feature.16453286
Alcoholic Intoxication, ChronicEpigenetic AlterationsRecently, it has been shown that the genomic DNA methylation in patients with alcoholism is increased.16463117
Alcoholic Intoxication, ChronicEpigenetic AlterationsUsing a multivariate model we observed that the increase (10%) of genomic DNA methylation in patients with alcoholism was significantly associated with their lowered DNMT-3b mRNA expression (multiple linear regression, p = 0.014).16463117
Stomach CarcinomaEpigenetic AlterationsHigh levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk.16467114
Carcinogenesis, Helicobacter pyloriEpigenetic AlterationsAlthough aberrant DNA methylation is deeply involved in gastric carcinogenesis, its induction by Helicobacter pylori, a strong gastric carcinogen, is unclear.16467114
TMEFF2 geneEpigenetic AlterationsExtensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis.16469793
TMEFF2 geneEpigenetic AlterationsHyperplastic polyposis of the colorectum is a precancerous condition that has been linked with DNA methylation.16469793
Serrated intestinal polyps, TMEFF2 geneEpigenetic AlterationsThe existence of distinguishing molecular features was explored in a series of serrated polyps and matched normal mucosa from patients with and without hyperplastic polyposis by assessing mutation of BRAF, DNA methylation in 14 markers (MINTs 1, 2 and 31, p16, MGMT, MLH1, RASSF1, RASSF2, NORE1 (RASSF5), RKIP, MST1, DAPK, FAS, and CHFR), and immunoexpression of MLH1.16469793
TMEFF2 geneEpigenetic AlterationsA more clearcut difference in patients with hyperplastic polyposis was the finding of extensive DNA methylation in normal mucosa from the proximal colon.16469793
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsAccumulation of DNA methylation is associated with tumor stage in gastric cancer.16475210
NeoplasmsEpigenetic AlterationsDNA methylation of tumor-related genes accumulates in conjunction with tumor progression.16475210
Stomach CarcinomaEpigenetic AlterationsDNA methylation of CHFR is not a predictor of the response to docetaxel and paclitaxel in advanced and recurrent gastric cancer.16475678
Malignant neoplasm of kidneyEpigenetic AlterationsGenetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer.16488999
Neoplasms, Renal Cell Carcinoma PathwayEpigenetic AlterationsGenetic and epigenetic changes in the von Hippel-Lindau (VHL) tumor suppressor gene are common in sporadic conventional renal cell carcinoma (cRCC).16488999
Breast CarcinomaEpigenetic AlterationsGenetic variants in epigenetic genes and breast cancer risk.16501248
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsEpigenetic events, resulting changes in gene expression capacity, are important in tumour progression, and variation in genes involved in epigenetic mechanisms might therefore be important in cancer susceptibility.16501248
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThese significant SNPs were genotyped in 75 human cancer cell lines from different tumour types to assess if there was an association between them and six epigenetic measures.16501248
Malignant neoplasm of breastEpigenetic AlterationsOur preliminary findings suggested that abnormal CDH1 methylation occurs in high frequencies in infiltrating breast cancers associated with a decrease in E-cadherin expression in a subgroup of cases characterized by loss of expression of other important genes to the mammary carcinogenesis process, probably due to the disruption of the mechanism of maintenance of DNA methylation in tumoral cells.16512896
Colonic NeoplasmsEpigenetic AlterationsImportantly, CIM of RASSF1A is an early epigenetic aberration, occurring in the absence of synchronous colon tumors and is not accompanied by field effects into the surrounding epithelium.16513682
Primary malignant neoplasmEpigenetic AlterationsThe change in DNA methylation patterns can be used to distinguish between normal and cancer cells.16516880
Stomach CarcinomaEpigenetic AlterationsGenetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus.16518809
Stomach CarcinomaEpigenetic AlterationsCIMP status appeared to be associated with distinct genetic, epigenetic, and clinicopathologic features in gastric carcinomas.16518809
Optic Atrophy, Hereditary, LeberEpigenetic AlterationsIt is also believed that several epigenetic factors have an influence on the development of LHON.16523300
NeoplasmsEpigenetic Alterationsp53 wild-type is a tumor suppressor gene involved in DNA gene transcription or DNA repair mechanisms.16525651
Hollings Cancer CenterEpigenetic AlterationsThese data indicate that the epigenetic aberrance of promoter CpG island hypermethylation of the GSTP1 gene may contribute to the hepatopathogenesis of HCC and is a potential valuable biomarker for noninvasive disease monitoring and HCC early diagnosis.16527261
Carcinoma of lungEpigenetic AlterationsUnique microRNA molecular profiles in lung cancer diagnosis and prognosis.16530703
Adenocarcinoma of lung (disorder)Epigenetic AlterationsmiRNA expression profiles correlated with survival of lung adenocarcinomas, including those classified as disease stage I.16530703
Carcinoma of lungEpigenetic AlterationsThese results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.16530703
Stomach CarcinomaEpigenetic AlterationsHypermethylation of the CDH1 promoter region seems to be the most common epigenetic mechanism in this gene silencing in gastric cancer.16531765
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsAberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy.16532500
Prostatic Hyperplasia, Prostate carcinoma, Prostate Cancer PathwayEpigenetic AlterationsThese results show that the transcriptional silencing of DLC-1 by two epigenetic mechanisms is common and may be involved in the pathogenesis of prostate carcinomas and benign prostatic hyperplasias and could have potential clinical application in the early detection and gene therapy of prostate cancer.16533763
Ductal CarcinomaEpigenetic AlterationsThe prevalence of DNA methylation of at least one of the 12 genes and the average number of methylated genes were significantly higher in both DEI (60% and 0.85 +/- 0.88, P = 0.0151 and P = 0.0224, respectively) and PanIN (67.5% and 0.95 +/- 0.85, P = 0.0014 and P = 0.0028, respectively) than in DE (15.4% and 0.15 +/- 0.38), and were further increased in ductal carcinoma (98.3% and 2.50 +/- 1.35, P < 0.0001 and P < 0.0001, respectively).16537562
Ductal Carcinoma, NeoplasmsEpigenetic AlterationsConsiderable heterogeneity of DNA methylation status was observed among multiple microdissected areas from individual ductal carcinomas, and the number of methylated genes per area was significantly correlated with poorer tumor differentiation (P = 0.0249).16537562
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThis is the first comprehensive study of the epigenetic dysregulation of the INK4 and CIP/KIP families of CKI in Chinese patients with CLL.16565223
Liver carcinomaEpigenetic AlterationsEpigenetic instability and chromosomal instability in hepatocellular carcinoma.16565510
HepatocarcinogenesisEpigenetic AlterationsWe found that the epigenetic instability phenotype and the chromosomal instability phenotype are not mutually exclusive in hepatocarcinogenesis and that they do not show a simple cause-and-effect relationship.16565510
Hollings Cancer CenterEpigenetic AlterationsFurthermore, we identified an epigenetic instability-dependent HCC that shows frequent epigenetic aberrations without chromosomal instability.16565510
Hepatocarcinogenesis, Hollings Cancer CenterEpigenetic AlterationsIn summary, by combined analyses of genetic and epigenetic aberration profiles in HCC, we obtained a comprehensive view of genomic alterations in hepatocarcinogenesis.16565510
Hollings Cancer CenterEpigenetic AlterationsThese data suggest that genetic, epigenetic and environmental exposure biomarkers in plasma may help in estimating the risk for the development of HCC.16570275
AutolysisEpigenetic AlterationsHistone methylation differences across various genomic sites were maintained within a wide range of autolysis times and tissue pH.16574239
Primary malignant neoplasmEpigenetic AlterationsWe thus have identified a new component of epigenetic TSG silencing that may potentially link some epigenetic changes associated with aging with those found in cancer, and provide new directions for therapeutically targeting these important genes for re-expression.16596166
FHIT gene, Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance.16598757
Non-Small Cell Lung CarcinomaEpigenetic AlterationsBoth genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event.16598760
Primary malignant neoplasmEpigenetic AlterationsEpigenetic changes during ageing and their relationship with cancer are under the focus of intense research.16606445
Neoplasms, Malignant tumor of small intestineEpigenetic AlterationsThe differences in the hypermethylation spectrum of small bowel and stomach cancer indicate significant epigenetic differences between these tumors.16619216
Parkinson DiseaseEpigenetic AlterationsTranscriptional changes in multiple system atrophy and Parkinsons disease putamen.16626704
Aplastic AnemiaEpigenetic AlterationsIn conclusion, when compared with normal controls, VEGF expression decreased significantly in patients with aplastic anemia at gene transcription level and protein translation level, it may be related to the defect of angiogenesis and thus hematopoiesis in bone marrow of patients with aplastic anemia.16638198
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumor suppressor genes by promoter hypermethylation has been shown for a variety of genes in bladder cancer.16642478
Liver carcinomaEpigenetic AlterationsDecreased dietary folate in an animal model of hepatocellular carcinoma has been associated with the induction of epigenetic silencing of the p16(INK4A) gene.16646054
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsFrequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers.16651412
Carcinogenesis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese results suggest that epigenetic silencing by hypermethylation of the CpG-rich promoter region of PCDH20 leads to loss of PCDH20 function, which may be a factor in the carcinogenesis of NSCLC.16651412
Malignant tumor of colonEpigenetic Alterationslet-7 microRNA functions as a potential growth suppressor in human colon cancer cells.16651716
Malignant tumor of colonEpigenetic AlterationsWhen let-7 low-expressing DLD-1 human colon cancer cells were transfected with let-7a-1 precursor miRNA, which is located at chromosome 9q22.3, the cells underwent significant growth suppression.16651716
Malignant tumor of colonEpigenetic AlterationsThese findings suggest the involvement of let-7 miRNA in the growth of colon cancer cells.16651716
Cessation of lifeEpigenetic AlterationsmiRNAs have been implicated in many cellular processes including cell proliferation, differentiation, and death.16651716
Lung NeoplasmsEpigenetic AlterationsRecently, let-7 miRNAs were found to regulate human RAS oncogene expression and to be often down-regulated in human lung tumors.16651716
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAccordingly, deletion of the single active copy of 13q14.3 results in significant down-regulation of the candidate genes and loss of function, providing a model for the interaction of genetic lesions and epigenetic silencing at 13q14.3 in B cell chronic lymphocytic leukemia.16684883
NeoplasmsEpigenetic AlterationsWe used the high frequency and specificity of individual DNA mutations in these tumors (MSI at 17 loci) and the early timing of epigenetic events (methylation of 7 gene promoters) to investigate tumor clonality.16697867
Non-Small Cell Lung CarcinomaEpigenetic AlterationsFrequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.16698880
Colorectal NeoplasmsEpigenetic AlterationsEpigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis.16699497
Colorectal CarcinomaEpigenetic AlterationsMost previous studies on CpG island methylation in colorectal carcinoma used methylation-specific PCR, which may detect low levels of DNA methylation with little or no biological significance.16699497
Colorectal NeoplasmsEpigenetic AlterationsHowever, no study to date has quantified DNA methylation of CIMP-specific promoters in synchronous colorectal neoplasias.16699497
Carcinoma, Adenoma, NeoplasmsEpigenetic AlterationsUtilizing real-time PCR (MethyLight), we quantified DNA methylation in five CIMP-specific gene promoters [CACNA1G (calcium channel, voltage-dependent, T type alpha-1G subunit), CDKN2A (p16/INK4A), CRABP1 (cellular retinoic acid binding protein-1), MLH1 and NEUROG1 (neurogenin 1)] and MGMT in six synchronous carcinoma pairs (12 carcinomas) and eight synchronous carcinoma and adenoma pairs (16 tumors).16699497
Colorectal CarcinomaEpigenetic AlterationsThe CpG island methylator phenotype (CIMP) with extensive promoter methylation appears to be a distinct epigenetic subtype of colorectal carcinoma.16699497
Colorectal NeoplasmsEpigenetic AlterationsIn conclusion, epigenetic alterations at CIMP-specific promoter CpG islands in synchronous colorectal neoplasias likely have both random and nonrandom components.16699497
Malignant neoplasm of kidneyEpigenetic AlterationsIdentification of novel target genes by an epigenetic reactivation screen of renal cancer.16707423
Childhood LeukemiaEpigenetic AlterationsDNA methylation changes after 5-aza-2-deoxycytidine therapy in patients with leukemia.16707479
Malignant tumor of colon, NeoplasmsEpigenetic AlterationsThe aberrant methylation of genes is an alternate, epigenetic mechanism for silencing tumor suppressor genes in colon cancer.16708352
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsEpigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma.16708382
Primary malignant neoplasmEpigenetic AlterationsPolymorphisms in genes involved in folate metabolism may influence DNA methylation, nucleotide synthesis, and thus individual susceptibility to cancer.16723031
Breast Cancer Cell, Premature aging syndromeEpigenetic AlterationsEpigenetic inactivation of the premature aging Werner syndrome gene in human cancer.16723399
Chromosomal Instability, Hypersensitivity, Primary malignant neoplasmEpigenetic AlterationsThese findings highlight the importance of WRN epigenetic inactivation in human cancer, leading to enhanced chromosomal instability and hypersensitivity to chemotherapeutic drugs.16723399
Esophageal Diseases, Primary malignant neoplasmEpigenetic AlterationsDNA methylation in esophageal diseases including cancer: special reference to hMLH1 gene promoter status.16724696
Malignant Neoplasms, Prostate Cancer PathwayEpigenetic AlterationsOverexpression of the enhancer of zeste homolog 2 (EZH2) protein, a known repressor of gene transcription, has been reported to be associated with biological malignancy of prostate cancer and several other cancers.16734726
NeoplasmsEpigenetic AlterationsMoreover, mutations in RIS1 in MSI-H tumors correlated with the epigenetic silencing of MLH1 (P = 0.04).16737913
Endometrial CarcinomaEpigenetic AlterationsEpigenetic inactivation of hMLH1, CDKN2A, and MGMT may be a common and early event in the development of synchronous primary endometrial and ovarian carcinomas and may qualify as a marker of a field cancerization encompassing the ovary and endometrium.16740754
Diffuse Large B-Cell LymphomaEpigenetic AlterationsLack of MGMT protein expression is associated with aberrant promoter DNA methylation and appears to be a useful marker for predicting the survival of DLBCL patients.16757436
Lymphoma, Non-HodgkinEpigenetic AlterationsDiscovery of novel epigenetic markers in non-Hodgkins lymphoma.16774933
Malignant Neoplasms, Lymphoma, Non-Hodgkin, Lymphoma, Large-Cell, FollicularEpigenetic AlterationsNon-Hodgkins lymphoma (NHL) is a group of malignancies with heterogeneous genetic and epigenetic alterations.16774933
Carcinoma, Transitional CellEpigenetic AlterationsDNA methylation alterations in urothelial carcinoma.16775427
melanomaEpigenetic AlterationsEpigenetic silencing of the PTEN gene in melanoma.16818626
melanoma, NeoplasmsEpigenetic AlterationsIn summary, epigenetic PTEN silencing seems to be a relevant mechanism of inactivating this tumor suppressor gene in melanoma that may promote melanoma development by derepression of the AKT pathway.16818626
Malignant tumor of colon, Colonic adenomasEpigenetic AlterationsIn addition, some investigators have identified an age-related increase in DNA methylation of the ESR1 locus in the colon mucosa, suggesting that DNA methylation may be a pre-neoplastic change that increases the risk of colon adenomas and colon cancer.16820927
Malignant NeoplasmsEpigenetic AlterationsThe aberrant methylation of CpG islands is a common epigenetic alteration found in cancers.16820927
CarcinogenesisEpigenetic AlterationsWe speculate that not only genetic but also epigenetic alterations are involved in the carcinogenesis due to chromium.16828922
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsWe analyzed P4 epigenetic alteration using methylation-specific PCR in 34 hepatocellular carcinoma (HCC) specimens, 34 matched adjacent nontumor specimens, and 8 normal adult liver specimens.16857788
Malignant NeoplasmsEpigenetic AlterationsEpigenetic silencing of functionally important genes is important in the development of malignancies and is a source of potential markers for molecular detection.16858686
Primary central nervous system lymphomaEpigenetic AlterationsOur study provides insight into the epigenetic alterations in PCNSL and provides potential biomarkers of disease.16858686
NeoplasmsEpigenetic AlterationsPromoter methylation inactivates expression of some important tumor suppressor genes and may be associated with histone modification.16863736
Aggressive behavior, Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur results indicate that ASC promoter hypermethylation is a common event in patients with primary NSCLC, and this epigenetic alteration is associated with inferior survival, suggesting that ASC promoter hypermethylation might be an important biomarker for a biologic, aggressive disease in NSCLC.16870048
Liver carcinomaEpigenetic AlterationsGenetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma.16872311
Hollings Cancer CenterEpigenetic AlterationsThe results suggest that genetic and epigenetic alteration of KLF6 may play a minor role in the development of HCC.16872311
NeoplasmsEpigenetic AlterationsHowever, genetic and epigenetic characteristics of these tumors were scarcely reported.16890591
Malignant NeoplasmsEpigenetic AlterationsDifferential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data.16928264
CarcinogenesisEpigenetic AlterationsEpigenetic gene silencing is one of the major causes of carcinogenesis.16928264
NeoplasmsEpigenetic AlterationsDetection of methylation for critical loci is potentially useful as epigenetic markers in tumor classification.16928264
CarcinogenesisEpigenetic AlterationsBy altering both DNA methylation and nucleotide synthesis, folate metabolism is thought to contribute to colorectal carcinogenesis.16941173
NeoplasmsEpigenetic AlterationsDespite the role of DNMT3B in de novo DNA methylation, a correlation between DNMT3B expression and promoter DNA methylation has not being established in tumors.16951144
NeoplasmsEpigenetic AlterationsAn inverse correlation was found between tumor MLH1 RNA expression and MLH1 DNA methylation (P=0.003).16951227
Stomach CarcinomaEpigenetic AlterationsQuantitative analysis of DNA methylation using DNA microarrays is a promising method for risk assessment in the development of gastric cancer.16952303
Malignant tumor of colonEpigenetic AlterationsA genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer.16952549
Malignant tumor of colonEpigenetic AlterationsTo identify novel methylation targets in colon cancer, we conducted a genome-wide, microarray-based, in silico, and epigenetic search.16952549
Primary malignant neoplasmEpigenetic AlterationsSubsequent epigenetic analysis revealed that primary colon cancers demonstrated frequent methylation of somatostatin (SST, 30 of 34 cases, 88%) and the substance P precursor gene tachykinin-1 (TAC1; 16 of 34 cases, 47%).16952549
Stomach CarcinomaEpigenetic AlterationsThe epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration.16959213
Stomach NeoplasmsEpigenetic AlterationsHere, we report for the first time the epigenetic silencing of LIMS2 in gastric tumors.16959213
Stomach Carcinoma, Metastasis, NeoplasmsEpigenetic AlterationsThese results suggest that the frequent inactivation of LIMS2 by epigenetic alteration in gastric cancer may be important in tumor progression events, such as invasion and metastasis.16959213
Colorectal Cancer PathwayEpigenetic AlterationsGenetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer.16969349
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer (CRC) develops as multistep process, which involves genetic and epigenetic alterations.16969349
Chronic Lymphocytic LeukemiaEpigenetic AlterationsProgressive disease in chronic lymphocytic leukemia is correlated with the DNA methylation index.16970987
NCI CTEP SDC Oligodendroglial Tumors Sub-Category TerminologyEpigenetic AlterationsDNA methylation and allelic losses on chromosome arm 14q in oligodendroglial tumours.16972885
Glioma, NeoplasmsEpigenetic AlterationsIn addition, the restriction of 14q32.12 methylation to oligodendroglial tumours suggests a role for epigenetic DNA modifications in these particular gliomas.16972885
Acoustic NeuromaEpigenetic AlterationsDNA methylation of multiple genes in vestibular schwannoma: Relationship with clinical and radiological findings.16983315
NeoplasmsEpigenetic AlterationsThe effects of epigenetic factors determining the intensity of somatic mutagenesis of p53 in tumors should be taken into account.16984108
NeoplasmsEpigenetic AlterationsSome tumors showed concomitant APC, sFRP1 and WIF-1 gene inactivation, indicating that multiple DNA methylation events must have occurred to definitively down-regulate the signaling through Wnt.16991125
effusionEpigenetic AlterationsThe increased E-cadherin expression in effusions may be related to lack of negative regulation at the epigenetic level.16996643
Lymphoma, Large-Cell, Follicular, InflammationEpigenetic AlterationsNutrients that affect inflammation, vitamin D activity, oxidative DNA damage, or DNA methylation may be associated with risk of NHL.17005624
NeoplasmsEpigenetic AlterationsCelecoxib reduced angiogenesis and induced tumor transcriptional changes.17008411
Anaplastic astrocytomaEpigenetic AlterationsThus, this epigenetic change is unlikely to play an important role in the evolution and development of malignant astrocytomas.17016577
HyperplasiaEpigenetic AlterationsWe concluded that Cyclin D2 promoter methylation downregulates gene transcription and occurs with high frequency at low levels in normal, hyperplastic, and preneoplastic prostate tissues.17016690
Primary malignant neoplasmEpigenetic AlterationsInactivation of cell-cycle regulating genes, such as p14ARF and p16INK4a, and cell adhesion genes, such as E-cadherin, is common in cancer, and results from genetic and/or epigenetic alterations.17017004
NeoplasmsEpigenetic AlterationsHypermethylation of CpG islands, caused by the action of DNA methyltransferases (DNMTs), is a major form of epigenetic inactivation of the p14ARF and p16INK4a genes in tumours.17017004
Carcinoma, Transitional CellEpigenetic AlterationsTo test DNA methylation profiling in detection of urothelial carcinoma in urine.17017434
S100A4 protein, human, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe DNA methylation paradox, manifested as derepression of cancer-testis antigens, and silencing of tumor suppressors during malignant transformation, provides the rationale for the utilization of chromatin remodeling agents for cancer therapy.17020984
Malignant Neoplasms, Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, NeoplasmsEpigenetic AlterationsEpigenetic mechanisms involving DNA methylation and chromatin remodeling are important in silencing tumor suppressor genes (TSG) in various malignancies, including renal cell carcinoma (RCC).17029774
Squamous cell carcinoma of skinEpigenetic AlterationsEpigenetic abnormalities in cutaneous squamous cell carcinomas: frequent inactivation of the RB1/p16 and p53 pathways.17034532
CarcinogenesisEpigenetic AlterationsOur findings indicate that the promoter hypermethylation of cancer-related genes, especially CDH1, is frequently shown in SCCs, and dysregulation of the RB1/p16 and/or p53 pathway through either genetic or epigenetic mechanisms, except for epigenetic abnormalities of p53 itself, should contribute to the carcinogenesis of SCCs.17034532
Prostate Cancer PathwayEpigenetic AlterationsDNA methylation of the RIZ1 gene is associated with nuclear accumulation of p53 in prostate cancer.17052263
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsAll four PCa specimens with nuclear accumulation of p53 were stage III disease and showed DNA methylation of RIZ1.17052263
Malignant NeoplasmsEpigenetic AlterationsHowever, of the remaining 43 cancers without nuclear accumulation of p53, DNA methylation of RIZ1 was observed in only 16 (37.2%) specimens (P = 0.0272).17052263
CarcinogenesisEpigenetic AlterationsThese results suggest that transcriptional inactivation of RIZ1 by aberrant DNA methylation may contribute to prostate carcinogenesis.17052263
ThalassemiaEpigenetic AlterationsThe PXE phenotype seen in some patients with beta thalassemia appears to be associated with epigenetic modification of ABCC6 transcription and depends specifically on the beta globin locus.17053732
Mammary NeoplasmsEpigenetic AlterationsEpigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours.17071074
Breast CarcinomaEpigenetic AlterationsWe assessed expression of the BRCA1, CTCF and DNMT3b methyltransferase genes along with BRCA1 promoter methylation to better define the epigenetic events involved in BRCA1 inactivation in sporadic breast cancer.17071074
Neoplasms, Mammary NeoplasmsEpigenetic AlterationsWe suggest that these altered CTCF and DNMT3b expression patterns represent (a) critical events responsible for the epigenetic inactivation of BRCA1 and (b) a diagnostic signature for epigenetic inactivation of other tumour suppressor genes in sporadic breast tumours.17071074
Adenocarcinoma of prostateEpigenetic AlterationsUp-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma.17071602
DICER1 protein, humanEpigenetic AlterationsDicer, an RNase III endonuclease, is an essential component of the microRNA machinery.17071602
Adenocarcinoma of prostateEpigenetic AlterationsDicer up-regulation may explain an almost global increase of microRNA expression in prostate adenocarcinoma.17071602
Adenocarcinoma of prostateEpigenetic AlterationsThe presence of up-regulated microRNA machinery may predict the susceptibility of prostate adenocarcinoma to RNA interference-based therapy.17071602
Adenocarcinoma of prostateEpigenetic AlterationsIn prostate adenocarcinoma, 39 microRNAs are up-regulated, and six microRNAs are down-regulated.17071602
Stomach CarcinomaEpigenetic AlterationsUsing methylated CpG island amplification coupled with representational difference analysis to identify genes inactivated by DNA methylation in gastric cancer, we identified seven DNA fragments corresponding to the 5 CpG islands of the affected genes.17083569
Stomach CarcinomaEpigenetic AlterationsIdentification of DFNA5 as a target of epigenetic inactivation in gastric cancer.17083569
Primary malignant neoplasmEpigenetic AlterationsEpigenetic gene inactivation plays a key role in the development of various types of cancer.17083569
Gallbladder Carcinoma, NeoplasmsEpigenetic AlterationsFrequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma.17084965
Malignant Neoplasms, Cervical Intraepithelial NeoplasiaEpigenetic AlterationsThese findings suggest that CIN and CIMP represent 2 independent and inversely related mechanisms of genetic and epigenetic instability in sporadic CRCs and confirm that MSI cancers arise as a consequence of CIMP.17087942
Clinical Coordinator, Carcinogenesis, Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation plays an important role during colorectal cancer (CRC) carcinogenesis.17093909
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese results provide clear evidence for the prognostic significance of p16(INK4a) methylation in NSCLC using quantitative DNA methylation analysis.17094392
Malignant tumor of colonEpigenetic AlterationsIt has been proposed that dietary factors such as folate, alcohol and methionine may be associated with colon cancer because of their involvement in DNA methylation processes.17096326
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAlthough hypermethylation was not found at the promoter region, the RhoB expression in NSCLC cell lines was induced by histone deacetylase inhibition, suggesting that RhoB downregulation may be due to histone modification.17096327
Nasopharyngeal carcinoma, DLEC1 protein, humanEpigenetic AlterationsEpigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma.17099870
Malignant tumor of colon, Malignant NeoplasmsEpigenetic AlterationsThe identification of novel genetic and epigenetic markers indicative of changes in the pathogenesis of colon cancer, along with easier-to-use, more sensitive assay methods, may improve the detection, treatment, and overall prognosis of this malignancy.17101318
Fragile X Syndrome, Peroxisome Biogenesis Disorder, Complementation Group G, Mental RetardationEpigenetic AlterationsFragile X syndrome, the most common form of inherited mental retardation in males, arises when the normally stable 5 to 50 CGG repeats in the 5 untranslated region of the fragile X mental retardation protein 1 (FMR1) gene expand to over 200, leading to DNA methylation and silencing of the FMR1 promoter.17101793
Skin Basal Cell CarcinomaEpigenetic AlterationsEpigenetic silencing contributes to frequent loss of the fragile histidine triad tumour suppressor in basal cell carcinomas.17107382
Tyrosine Transaminase Deficiency Disease, NeoplasmsEpigenetic AlterationsWe have identified epigenetic silencing of the FHIT tumour suppressor gene as a frequent inactivation mechanism which is likely to contribute to functional deficiencies in DNA damage response of BCCs.17107382
ArteriosclerosisEpigenetic AlterationsWe suggest that focal epigenetic changes in estrogen receptor beta contribute to the development of atherosclerosis and vascular aging.17110088
Carcinogenesis, Colorectal Cancer PathwayEpigenetic AlterationsFolate deficiency has been associated with colorectal cancer risk and may be involved in colorectal carcinogenesis through increased chromosome instability, gene mutations, and aberrant DNA methylation.17116713
Malignant NeoplasmsEpigenetic AlterationsIt is possible that deregulation of miRNA may contribute to the oncogenesis of some cancers.17121874
Primary malignant neoplasmEpigenetic AlterationsLittle is known about the role of miRNAs in normal and cancer cells.17121874
Esophageal Neoplasms, Squamous cell carcinoma of esophagusEpigenetic AlterationsReprimo methylation occurs significantly more frequently in BE, HGD, and EAC than in NE or ESCC, suggesting that this epigenetic alteration is a specialized columnar, cell-specific early event with potential as a biomarker for the early detection of esophageal neoplasia.17121882
Liver carcinomaEpigenetic AlterationsFrequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma.17121887
Adenoma, NeoplasmsEpigenetic AlterationsFlat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas.17143260
NeoplasmsEpigenetic AlterationsHowever, the accurate frequencies of genetic and epigenetic alterations in flat-type colorectal advanced adenomas (laterally spreading tumors) have remained largely unknown.17143260
AdenomaEpigenetic AlterationsEpigenetic alterations infrequently occurred in flat-type advanced adenomas, suggesting that they have different genetic and epigenetic alterations from those of protruded-type advanced adenomas.17143260
Refractory Cytopenia of ChildhoodEpigenetic AlterationsThis is the first report showing that M score analysis of Wnt antagonist genes can serve as an excellent epigenetic biomarker panel for detection, staging, and prognosis of RCC using serum DNA.17145819
Acute lymphocytic leukemiaEpigenetic AlterationsEpigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia.17148581
Prostate Cancer Pathway, Prostatic Intraepithelial NeoplasiasEpigenetic AlterationsDNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation.17164146
Initiation, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur results demonstrate that 15-LO-1 promoter methylation is frequently present in PCa patients and identify a new role for epigenetic phenomenon in PCa wherein hypermethylation of the 15-LO-1 promoter leads to the upregulation of 15-LO-1 expression and enzyme activity contributes to PCa initiation and progression.17164146
Colorectal CarcinomaEpigenetic AlterationsColorectal cancers are characterized by genetic and epigenetic alterations.17167178
Colorectal Carcinoma, Colorectal NeoplasmsEpigenetic AlterationsGenetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers.17183069
Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation and histone deacetylation participate in cancer development and progression; hence, their reversal by inhibitors of DNA methylation and histone deacetylases (HDACs) is at present undergoing clinical testing in cancer therapy.17183730
Colorectal Carcinoma, Neoplasm MetastasisEpigenetic AlterationsIn a gene evaluation set consisting of sera from 24 patients with local colorectal cancers, 14 with metastasized disease, and 20 healthy controls, the genes HPP1/TPEF, HLTF, and hMLH1 were identified as potential serum DNA methylation markers.17189406
Primary malignant neoplasmEpigenetic AlterationsIt is well known that epigenetic alterations such as DNA methylation of CpG dinucleotides located in CpG islands within the regulatory (promoter) regions of genes are associated with transcriptional silencing in cancer.17192040
NeoplasmsEpigenetic AlterationsWe could assess the DNA methylation status of an average of 2,012 CpG islands for each tumor.17192040
Lung NeoplasmsEpigenetic AlterationsAmong 162 sites of differential DNA methylation, detected from at least one tumor/normal pair, 21 hypermethylated genes were identified that were not reported previously as hypermethylated in lung tumor tissue.17192040
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsHowever, DNA methylation markers that are highly specific and sensitive for common tumors would be useful for the early detection of cancer, and those required for the malignant phenotype would identify pathways important as therapeutic targets.17194187
Carcinoma of lungEpigenetic AlterationsThe epigenetic inactivation of genes plays an important role in lung cancer.17196704
Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur results show that the hypermethylation frequency of single genes and the accumulation of epigenetic alterations in individual samples of NSCLC patients may vary considerably.17196704
CarcinogenesisEpigenetic AlterationsAberrant DNA methylation has been shown to play important roles during multistage carcinogenesis in various human organs.17196739
Pancreatic carcinomaEpigenetic AlterationsThese preliminary observations suggest that plasma DNA might be a useful surrogate in detecting genetic and epigenetic alterations of pancreatic cancer.17198183
Pancreatic carcinomaEpigenetic AlterationsFurther studies on environmental modulators of epigenetic changes in pancreatic cancer are warranted.17198183
Malignant neoplasm of stomachEpigenetic AlterationsFolate deficiency has been implicated in the etiology of stomach cancer through abnormal DNA methylation and disrupted DNA synthesis and repair.17220339
Endometrial CarcinomaEpigenetic AlterationsEpigenetic silencing of MLH1 is the most common cause of defective DNA mismatch repair in endometrial and colorectal cancers.17230510
Malignant NeoplasmsEpigenetic AlterationsIdentification of risk alleles for MLH1 methylation could shed light on mechanisms of epigenetic silencing and may ultimately lead to new approaches to the prevention or treatment of malignancies associated with MLH1 inactivation.17230510
Malignant neoplasm of pancreas, Adenocarcinoma of pancreasEpigenetic AlterationsSPARC undergoes epigenetic silencing in many pancreatic cancers, but stromal fibroblasts adjacent to infiltrating pancreatic adenocarcinomas frequently express SPARC.17235047
NeoplasmsEpigenetic AlterationsThe objective of this study was to develop a reliable, clinically validated assay for detection of epigenetic silencing of the MGMT gene using formalin-fixed, paraffin-embedded brain tumor resections and methylation-specific PCR.17260000
NeoplasmsEpigenetic AlterationsThirteen genes were analyzed for DNA methylation: the pro-apoptotic CASP8, CASP3, CASP9, DcR1, DR4, DR5 and TMS1; the cell adherence CDH1 and CDH13; the candidate tumor suppressor RASSF1A and BLU; the cell cycle regulator CHFR and the DNA repair MGMT.17272309
NeoplasmsEpigenetic AlterationsThe CpG island promoter hypermethylation profile of relapsed GBM in comparison with their corresponding primary tumors was identical in 37.5% of the cases, whereas in 62.5% of patients, differences in the DNA methylation patterns of the 13 genes were observed.17272309
Lynch SyndromeEpigenetic AlterationsEvidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas.17278092
Clinical Coordinator, Hereditary Malignant NeoplasmEpigenetic AlterationsThe role of epigenetic alterations, such as aberrant DNA methylation, in the polyp-cancer sequence in sporadic CRC and particularly in hereditary colon cancer is not well understood.17278092
Adenoma, Clinical Coordinator, polyps, Lynch Syndrome, Malignant tumor of colonEpigenetic AlterationsConsequently, we assessed the methylation status of CDKN2A/p16, MGMT, MLH1 and p14(ARF) in adenomas arising in the Lynch syndrome, a familial colon cancer syndrome caused by MLH1 and MSH2 mutations, to determine if DNA methylation is a "second hit" mechanism in CRC and to characterize the role of DNA methylation in the polyp phase of the Lynch syndrome.17278092
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer (CRC) forms through a series of histologic steps that are accompanied by mutations and epigenetic alterations, which is called the polyp-cancer sequence.17278092
Squamous cell carcinomaEpigenetic AlterationsHuman papillomavirus-16 DNA methylation patterns support a causal association of the virus with oral squamous cell carcinomas.17278110
precancerous lesions, Malignant Lesion, InfectionEpigenetic AlterationsOur previous investigations of HPV-16 DNA methylation in anogenital sites have identified hypermethylation of the L1 gene and part of the long control region in many malignant lesions, but rarely in asymptomatic infections and low-grade precancerous lesions.17278110
Oral Cavity Carcinoma, Carcinoma, Malignant LesionEpigenetic AlterationsThese data indicate epigenetic changes of HPV-16 in oral carcinomas similar to those in anogenital carcinomas, suggesting carcinogenic processes under the influence of HPV-16 in most if not all of these oral malignant lesions.17278110
CarcinogenesisEpigenetic AlterationsAccumulating evidence implicates epigenetic changes such as hypermethylation in carcinogenesis.17285579
Hepatocarcinogenesis, Hollings Cancer Center, Liver carcinomaEpigenetic AlterationsTo gain insight into the role of epigenetic aberration of tumor-related genes in hepatocarcinogenesis, we determined a hypermethylation profile in hepatocellular carcinoma (HCC).17289889
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe epigenetic regulation of the PDGF-B gene dictates whether TGFbeta acts as an oncogenic factor inducing PDGF-B and proliferation in human glioma.17292826
Malignant tumor of colonEpigenetic AlterationsAPC mutations and other genetic and epigenetic changes in colon cancer.17293392
Malignant tumor of colonEpigenetic AlterationsThe relationships of APC mutations to other genetic and epigenetic alterations add to the already impressive genetic heterogeneity of colon cancer.17293392
Malignant neoplasm of stomachEpigenetic AlterationsGenetic and epigenetic analysis of the EPHB2 gene in gastric cancers.17295683
Stomach Carcinoma, Malignant neoplasm of stomachEpigenetic AlterationsA search was made for mutations at the A9 tract in exon 17, an allelic loss at the EPHB2 gene locus, and promoter hypermethylation of the EPHB2 gene in 81 sporadic gastric cancers in order to determine if genetic or epigenetic alterations of the EPHB2 gene are involved in the development and/or progression of gastric cancer.17295683
Malignant neoplasm of stomachEpigenetic AlterationsTherefore, genetic or epigenetic alterations of the EPHB2 gene might be an uncommon event in the development or progression of gastric cancers.17295683
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMethylation of the promoter region of tumor suppressor genes is increasingly recognized to play a role in cancer development through silencing of gene transcription.17301267
Hereditary Nonpolyposis Colorectal Cancer, Primary malignant neoplasmEpigenetic AlterationsPersons who have hypermethylation of one allele of MLH1 in somatic cells throughout the body (a germ-line epimutation) have a predisposition for the development of cancer in a pattern typical of hereditary nonpolyposis colorectal cancer.17301300
Primary malignant neoplasmEpigenetic AlterationsThese findings demonstrate a novel pattern of inheritance of cancer susceptibility and are consistent with transgenerational epigenetic inheritance.17301300
ovarian neoplasmEpigenetic AlterationsEpigenetic silencing of HSulf-1 in ovarian cancer:implications in chemoresistance.17310998
ovarian neoplasmEpigenetic AlterationsCollectively, these data indicate that HSulf-1 is epigenetically silenced in ovarian cancer and that epigenetic therapy targeting HSulf-1 might sensitize ovarian tumors to conventional first-line therapies.17310998
malignant disease, NeoplasmsEpigenetic AlterationsAccumulating evidence suggests that MMP promoter single nucleotide polymorphisms (SNPs) effecting gene transcription are associated with enhanced susceptibility for the development of malignant disease, increased tumour invasiveness and poor patient survival.17311017
oligodendroglioma, NeoplasmsEpigenetic AlterationsBecause little is known about the evolution of genetic and epigenetic changes that occur during tumor progression in oligodendrogliomas, we evaluated these changes in paired early and progressive oligodendrogliomas.17332285
Clinical Coordinator, precancerous lesionsEpigenetic AlterationsMethylation testing of fecal DNA using a panel of epigenetic markers may be a simple and promising non-invasive screening method for CRC and precancerous lesions.17352030
Mouse mammary tumor virus, CXCL14 gene, NeoplasmsEpigenetic AlterationsOncogenic wingless-related mouse mammary tumour virus (Wnt) signalling, caused by epigenetic inactivation of specific pathway regulators like the putative tumour suppressor secreted frizzled-related protein 1 (SFRP1), may be causally involved in the carcinogenesis of many human solid tumours including breast, colon and kidney cancer.17353908
Cervical AdenocarcinomaEpigenetic AlterationsAlthough the incidence of cervical adenocarcinoma is increasing, few genetic and epigenetic changes in its progression have been described.17360030
Squamous cell carcinoma, AdenocarcinomaEpigenetic AlterationsDifferent genetic/epigenetic alterations may explain the possible different therapeutic responsiveness between adenocarcinoma and squamous cell carcinoma of uterine cervix seen in clinic.17360030
NeoplasmsEpigenetic AlterationsOur data suggest that gene mutation and/or epigenetic events that cannot be detected by assay of gross alteration of chromosomal structure are likely to underlie the malignant transformation events of this tumor type.17372589
Colorectal CarcinomaEpigenetic AlterationsUtilizing real-time polymerase chain reaction (PCR; MethyLight technology), we quantified DNA methylation in 13 CpG island loci (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3, SOCS1, MINT1, MINT31, IGFBP3, MGMT, and WRN) in 30 metastatic microsatellite stable colorectal carcinomas in phase I/II clinical trials of combination chemotherapy (5-fluorouracil, irinotecan, leucovorin, and gefitinib).17372756
Colorectal CarcinomaEpigenetic AlterationsThe CpG island methylator phenotype (CIMP) is a distinct epigenetic phenotype in colorectal carcinoma with concordant methylation in multiple promoter CpG islands.17372756
Colorectal Cancer PathwayEpigenetic AlterationsDietary folate status appears to influence risk for colorectal cancer possibly by alterations in DNA methylation and nucleotide precursor pools.17372834
Adenoma of large intestineEpigenetic AlterationsWe sought to determine the association between folate status, folate metabolism, DNA methylation, tobacco, alcohol consumption, and the risk of colorectal adenomas in African Americans.17372834
Colorectal NeoplasmsEpigenetic AlterationsOur results contribute to the hypothesis that altered DNA methylation and methyl metabolism is associated with colorectal neoplasia.17375119
Primary malignant neoplasmEpigenetic AlterationsEpigenetic mechanisms such as DNA methylation play important role in cancer.17383681
NeoplasmsEpigenetic AlterationsThere was concordance between DNA methylation in tumor and paired serum DNA of each gene.17383681
Breast CarcinomaEpigenetic AlterationsEpigenetic alterations involved in the onset and progression of breast cancer may serve as biomarkers for early detection and prediction of disease prognosis.17383681
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer.17388669
Carcinoma of lungEpigenetic AlterationsWe performed restriction landmark genomic scanning on 40 patient samples and identified 47 DNA methylation targets that together could distinguish the two lung cancer subgroups.17388669
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsDNA demethylating agents are used to reverse epigenetic silencing of tumor suppressors in cancer therapeutics.17389721
NeoplasmsEpigenetic AlterationsEpigenetic predictive models developed using artificial intelligence techniques identified the presence and timing of tumor progression with 97% specificity and 75% sensitivity.17404085
Ulcerative Colitis, DysplasiaEpigenetic AlterationsGiven that both genetic and epigenetic changes are common in UC mucosa and dysplasias, we speculate that the genetic changes lead to a more aggressive clinical course than epigenetic changes.17408633
Breast Carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer.17415710
Leukemia, Myelocytic, AcuteEpigenetic AlterationsClonogenic acute myelogenous leukemia cells are heterogeneous with regard to regulation of differentiation and effect of epigenetic pharmacological targeting.17416413
Prostate Cancer PathwayEpigenetic AlterationsDiscovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.17437806
Stomach CarcinomaEpigenetic AlterationsRisk prediction of gastric cancer by analysis of aberrant DNA methylation in non-neoplastic gastric epithelium.17438355
CarcinogenesisEpigenetic AlterationsAberrant DNA methylation is one of the major events in carcinogenesis.17438355
Stomach Carcinoma, Infection caused by Helicobacter pyloriEpigenetic AlterationsWe aimed to clarify the relationship of aberrant DNA methylation in non-neoplastic gastric epithelia with the risk of gastric cancer, Helicobactor pylori infection, and the degree of H. pylori-induced gastritis.17438355
Stomach Carcinoma, Peptic Ulcer, GastritisEpigenetic AlterationsThe status of aberrant DNA methylation was compared in two groups of patients: 43 cases with gastric cancer (mean age 65.9 years [29-91], F:M = 0.30, intestinal type [n = 25], diffuse type [n = 18]) and 46 age- and sex-matched patients without gastric cancer (peptic ulcer diseases [n = 11], gastritis [n = 35]) as a control group.17438355
Thyroid LymphomaEpigenetic AlterationsHLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese.17454594
Prostate Cancer PathwayEpigenetic AlterationsThis is the first report suggesting that reduced histone acetylation or H3K4me2 methylation and increased dimethyl-H3-K9 methylation play a critical role in the maintenance of promoter DNA methylation-associated RASSF1A gene silencing in prostate cancer.17473182
Prostate Cancer PathwayEpigenetic AlterationsEpigenetic modifications of RASSF1A gene through chromatin remodeling in prostate cancer.17473182
Stomach CarcinomaEpigenetic AlterationsGastric carcinoma is characterised by numerous genetic and epigenetic alterations that influence cell cycle progression, apoptosis and DNA repair.17483253
Colorectal NeoplasmsEpigenetic AlterationsEpigenetic alterations have been reported in colorectal neoplasia which can either complement or in some cases be predisposed to genetic alterations such as K-ras mutations.17487400
CarcinogenesisEpigenetic AlterationsThese findings strongly support the hypothesis that epigenetic mechanisms play an important role in the early steps of colorectal carcinogenesis.17487400
Degenerative polyarthritisEpigenetic AlterationsEpigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention.17502362
Myeloid Leukemia, ChronicEpigenetic AlterationsThese data suggest that the decrease in Shp1 in advanced stage CML patients is due to post-transcriptional modifications.17503411
Morphologically abnormal structure (morphologic abnormality)Epigenetic AlterationsThe anomaly persisted in lymphocytes cultured for 48 h. There was no evidence of abnormal DNA methylation, a major feature of constitutive heterochromatin and associated with the loss of its structure.17503660
Infection caused by Helicobacter pyloriEpigenetic AlterationsAberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication.17509026
Transitional cell carcinoma of bladderEpigenetic AlterationsWe analyzed epigenetic silencing of 16 genes in a population-based incident case series of 331 bladder transitional cell carcinomas.17522068
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsThis work, studying all stages and grades of incident bladder cancer, provides definitive evidence that carcinogen exposures play a critical role in selecting these alterations in tumorous clones and that epigenetic silencing is a strong and significant predictor of tumor stage and overall patient survival.17522068
GliomaEpigenetic AlterationsEpigenetic inactivation of the hMLH1 gene in progression of gliomas.17525680
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAberrant DNA methylation profiles of non-small cell lung cancers in a Korean population.17532092
Hepatitis B, Liver carcinomaEpigenetic AlterationsDifferential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma.17534893
Hepatobiliary DisorderEpigenetic AlterationsIn conclusion, aberrant DNA methylation may begin at different stages of liver disease in a gene-dependent manner.17534893
melanomaEpigenetic AlterationsGenetic and epigenetic alterations in the differential diagnosis of malignant melanoma and spitzoid lesion.17535228
NeoplasmsEpigenetic AlterationsThese results show that, although most atypical Spitz tumours do not differ from conventional Spitz naevi showing virtually no genetic and epigenetic aberrations, some cases may have chromosomal aberrations that include copy number loss of the CDKN2A gene.17535228
Epithelioid and spindle cell nevus, melanoma, NeoplasmsEpigenetic AlterationsGenetic and epigenetic analyses may be useful as an additional diagnostic tool to distinguish between melanoma and Spitz naevus, and may help to define subgroups in atypical Spitz tumours.17535228
Mammary NeoplasmsEpigenetic AlterationsAbnormalities in X chromosome copy number and in the epigenetic stability of the inactive X chromosome (Xi) have been proposed to characterize BRCA1 breast tumors.17545591
NeoplasmsEpigenetic AlterationsHowever, our data suggest that amplifications or mutations of this gene seldom occur in HNSCC and that epigenetic events can play an important role in advanced tumour stages.17549376
Malignant neoplasm of lungEpigenetic AlterationsEpigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers.17549418
Multiple MyelomaEpigenetic AlterationsEpigenetic dysregulation of the death-associated protein kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma.17557868
Primary malignant neoplasmEpigenetic AlterationsDysregulation of normal promoter usage has been shown to occur in cancer; DNA methylation regulates promoter use.17569086
ovarian neoplasmEpigenetic AlterationsThus, we sought to examine if DNA methylation varies among IGF-II promoters in ovarian cancer and if methylation patterns are related to clinical features of the disease.17569086
Primary malignant neoplasm, Cessation of lifeEpigenetic AlterationsFrom these findings, we propose that EGCG is effective in causing cell death in both MCF-7 and HL60 cancer cell lines and may work through different pathways involving both anti-oxidant effects and epigenetic modulation.17570133
CarcinomaEpigenetic AlterationsMLH1 HM was found in approximately 16% of polyps found in young patients and represents one of the epigenetic changes that may result in the subsequent progression to carcinoma along an accelerated sequence.17573746
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsDNA methylation profiling of myelodysplastic syndrome hematopoietic progenitor cells during in vitro lineage-specific differentiation.17577921
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsDeregulated epigenetic mechanisms are likely involved in the pathogenesis of myelodysplastic syndromes (MDSs).17577921
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, NeoplasmsEpigenetic AlterationsEpigenetic changes have been implicated in the pathogenesis of solid tumors, including head and neck squamous cell carcinoma (HNSCC).17582607
Squamous intraepithelial lesionEpigenetic AlterationsHuman papillomavirus DNA integration and messenger RNA transcription in cervical low- and high-risk squamous intraepithelial lesions in Austrian women.17587315
Malignant Head and Neck Neoplasm, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsPromoter hypermethylation of tumor suppressor genes is common in head and neck cancer as well as other primary cancers resulting in epigenetic gene silencing.17592394
NeoplasmsEpigenetic AlterationsSignificant association was observed between ERalpha and PRB methylation (p< or =0.001) and there was concordance between DNA methylation in tumor and serum for each gene.17599361
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThis study also underscores the potential utility of DNA methylation based screening of serum (a surrogate for tumor DNA methylation) as a tool for detection of breast cancer.17599361
Breast Carcinoma, European Organization for Research and Treatment of Cancer, tamoxifen, Primary malignant neoplasmEpigenetic AlterationsDNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group.17601725
Breast CarcinomaEpigenetic AlterationsOur aim was to identify and validate DNA-methylation markers associated with very good outcome in node negative, hormone receptor positive breast cancer patients after adjuvant endocrine therapy which might allow identifying patients who could be spared the burden of adjuvant chemotherapy.17601725
Colorectal NeoplasmsEpigenetic AlterationsLittle is known about epigenetic alterations in laterally spreading colorectal tumors (LSTs).17620311
Colorectal CarcinomaEpigenetic AlterationsUtilizing real-time polymerase chain reaction (MethyLight technology), we quantified DNA methylation in MGMT and eight other markers (a CIMP diagnostic panel including CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1 in 182 colorectal cancers collected from two prospective cohorts, the Nurses Health Study and the Health Professionals Follow-up Study.17621591
CarcinogenesisEpigenetic AlterationsThe epigenetics of ovarian carcinogenesis remains poorly described.17623056
Recurrent respiratory papillomatosisEpigenetic AlterationsTo investigate the contribution of promoter methylation-mediated epigenetic events in recurrent respiratory papillomatosis tumorigenesis.17638782
Recurrent respiratory papillomatosisEpigenetic AlterationsA clonal origin was derived for 5 of 15 recurrent respiratory papillomatosis biopsy specimens based on identical epigenetic events.17638782
Recurrent respiratory papillomatosis, NeoplasmsEpigenetic AlterationsThe high frequency of epigenetic events, characterized by consistent promoter hypermethylation of multiple tumor suppressor genes, points to the use of gene silencing mechanisms in the pathogenesis of recurrent respiratory papillomatosis.17638782
Clinical Coordinator, Colorectal Cancer Pathway, AdenomaEpigenetic AlterationsDNA methylation of secreted frizzled-related proteins (SFRPs) can be detected in colorectal cancer (CRC) tissue, in tissue of adenomas, and in aberrant crypt foci, whereas in normal colorectal mucosa tissue, SFRP genes are unmethylated.17639423
Prostate Cancer PathwayEpigenetic AlterationsThis is the first report showing that CYP7B1 is overexpressed in high-grade PIN and in prostate cancer and that local methylation of CYP7B1 promoter region may have significant effect on gene transcription.17639508
Malignant mesotheliomaEpigenetic AlterationsDNA methylation profile of 28 potential marker loci in malignant mesothelioma.17659810
Primary malignant neoplasmEpigenetic AlterationsDNA methylation changes in cancer cells provide powerful markers that are potentially detectable non-invasively in DNA shed into bodily fluids.17659810
Agenesis of corpus callosumEpigenetic AlterationsThese coexistent mutations/epigenetic inactivations in PI3K/AKT pathway may be responsible for the unusually aggressive course of ACC.17669465
NeoplasmsEpigenetic AlterationsThe E-cadherin gene methylation presence in tumors with lowest invasive and metastatic potential, such as VC, suggests the early involvement of this epigenetic event in the multistep progression of the oral carcinogenesis.17685455
AmeloblastomaEpigenetic Alterations[DNA methylation of human telomerase reverse transcriptase promoter region in human ameloblastoma].17686286
Malignant NeoplasmsEpigenetic AlterationsThe IHC findings in MSI-H cancers with methylation in distal or both regions of MLH1 promoter have not confirmed the epigenetic silencing of the MLH1 gene.17688369
Malignant NeoplasmsEpigenetic AlterationsThe polycomb group protein Enhancer of Zeste Homolg 2 (EZH2), a repressor of gene transcription, has been linked to the progression of various malignancies.17694325
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsMany cadherins (CDH) are associated with various types of cancer and their genetic and epigenetic alterations might be involved in carcinogenesis.17695513
Hodgkin Disease, Huntington DiseaseEpigenetic AlterationsTranscriptional dysregulation in Huntingtons disease (HD) is mediated in part by aberrant patterns of histone acetylation.17702032
Heart DiseasesEpigenetic AlterationsAltered microRNA expression in human heart disease.17712037
Heart DiseasesEpigenetic AlterationsThese data show that expression of many microRNAs is altered in heart disease and that different types of heart disease are associated with distinct changes in microRNA expression.17712037
Colorectal Cancer PathwayEpigenetic AlterationsmRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer.17716371
Malignant tumor of colon, High-Frequency Microsatellite InstabilityEpigenetic AlterationsBased on combined miRNA and mRNA gene expression, a molecular signature consisting of twenty seven differentially expressed genes, inclusive of 8 miRNAs, could correctly distinguish MSI-H versus MSS colon cancer samples.17716371
Microsatellite instability-high colorectal cancerEpigenetic AlterationsThis is the first report that indicates the existence of differences in miRNA expression between MSS versus MSI-H colorectal cancers.17716371
Breast Cancer CellEpigenetic AlterationsIn addition, the work suggests that the combination of mRNA/miRNA expression signatures may represent a general approach for improving bio-molecular classification of human cancer.17716371
Malignant NeoplasmsEpigenetic AlterationsAmong the differentially expressed miRNAs, various members of the oncogenic miR-17-92 family were significantly up-regulated in MSS cancers.17716371
Malignant neoplasm of gastrointestinal tractEpigenetic AlterationsOur aim was to clarify the expression profiles and epigenetic alterations of the HHIP gene in gastrointestinal cancer.17724792
Primary malignant neoplasm, Malignant neoplasm of gastrointestinal tractEpigenetic AlterationsThe expression and promoter epigenetic status of HHIP in cancer cell lines and freshly resected gastrointestinal cancer tissues were examined using RT-PCR, tissue microarray analysis, methylation-specific PCR, and chromatin immunoprecipitation assay.17724792
Parkinson DiseaseEpigenetic AlterationsWe identified a miRNA, miR-133b, that is specifically expressed in midbrain DNs and is deficient in midbrain tissue from patients with Parkinsons disease.17761882
Malignant neoplasm of breastEpigenetic AlterationsAberrant DNA methylation has been found frequently in human breast cancers, associated with the loss of expression of a number of regulatory genes for growth and correlated to clinical outcomes.17764565
Malignant Neoplasms, Primary NeoplasmEpigenetic AlterationsThis study examines whether gene-promoter hypermethylation could be detected in HNSCC surgical margins with no histologic evidence of malignancy, and if so, whether it reflects epigenetic events of primary tumors.17785562
Malignant NeoplasmsEpigenetic Alterations14-3-3 sigma has been a major G2/M checkpoint control gene and has demonstrated that its inactivation in various cancers occurs mostly by epigenetic hypermethylation, not by genetic change.17786341
CarcinogenesisEpigenetic AlterationsEpigenetic silencing of MGMT function by its promoter hypermethylation is considered to contribute to carcinogenesis.17825378
Breast CarcinomaEpigenetic AlterationsExcept for inherited forms of breast cancer, however, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior.17850661
Breast CarcinomaEpigenetic AlterationsThese findings suggest that epigenetic transcriptome changes, more than genotypic variation, account for age-associated differences in sporadic breast cancer incidence and prognosis.17850661
Neoplasms, LymphomaEpigenetic AlterationsAberrant hypermethylation of CpG islands in the promoter region of tumor suppressor and other important genes in neoplastic cells of lymphoma has been demonstrated to be one of the mechanisms for epigenetic loss of gene function.17852707
Carcinoma of lungEpigenetic AlterationsThese results suggest that the attenuated function of SIN3A due to a decreased level of expression may result in epigenetic de-regulation of growth-related genes through histone acetylation, which leads to the tumorigenesis of lung cancer cells.17854949
Breast CarcinomaEpigenetic AlterationsAtypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer risk.17855699
Germ-Line Mutation, Hereditary Nonpolyposis Colorectal Cancer, Lynch Syndrome, NeoplasmsEpigenetic AlterationsSome of the tumours are caused by hereditary mutations (hereditary nonpolyposis colon cancer or Lynch syndrome), but most are epigenetic changes of sporadic origin.17868408
Breast CarcinomaEpigenetic AlterationsWe recently found that DNA methylation of S100A2, spleen tyrosine kinase (SYK), and Stathmin-1 (STMN1) correlates with response to tamoxifen therapy in metastatic breast cancer.17874182
Primary malignant neoplasmEpigenetic AlterationsThe isolated cultures may provide a useful in vitro model to elucidate epigenetic effects on angiogenesis in cancer and to optimize antiangiogenic therapy.17876298
Multiple MyelomaEpigenetic AlterationsEpigenetic dysregulation of Wnt signaling pathway in multiple myeloma.17882284
Stomach CarcinomaEpigenetic AlterationsThe presence of high levels of aberrant DNA methylation in gastric mucosae correlates with risk of gastric cancer.17900260
Lymphoma, FollicularEpigenetic AlterationsFrequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular lymphoma.17900658
Lymphoma, Follicular, Mantle cell lymphomaEpigenetic AlterationsIn summary, most patients with mantle cell lymphoma and follicular lymphoma had epigenetic aberrations targeting the INK4/Rb pathway.17900658
Carcinoma of lungEpigenetic AlterationsEpigenetic inactivation of genes by promoter hypermethylation, a major mechanism in the initiation and progression of tobacco-induced cancer, has also been associated with lung cancer induced through environmental and occupational exposures.17903034
Tetranitromethane, NeoplasmsEpigenetic AlterationsThe RPA classified the patients into seven distinct prognostic groups based on TNM stage (first node), histology, and histone modifications: H3K4diMe (< or 85% tumor cells), H3K9Ac (< or 68% tumor cells), and H2AK5Ac (< or 5% tumor cells).17906200
Primary malignant neoplasmEpigenetic AlterationsEpigenetic modifications may contribute to the development and progression of cancer.17906200
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe prognostic influence of epigenetic changes involving multiple histones, in particular H2A and H3, is greater in early NSCLC, and evaluation of these changes may help in selecting early-stage NSCLC patients for adjuvant treatment.17906200
Chronic Obstructive Airway DiseaseEpigenetic AlterationsImpaired TNFalpha-induced VEGF expression in human airway smooth muscle cells from smokers with COPD: role of MAPkinases and histone acetylation--effect of dexamethasone.17906365
Chronic Obstructive Airway DiseaseEpigenetic AlterationsVEGF expression is directly modulated by phosphorylation of ERK-1,-2 and p38MAPK and by histone acetylation and the acetylation status of the VEGF gene is increased in HASMC of smokers with COPD in a smoking-independent manner.17906365
Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer.17909015
Colorectal Cancer PathwayEpigenetic AlterationsLong-range epigenetic silencing of contiguous genes has been found on chromosome 2q14 in colorectal cancer.17909015
Colorectal CarcinomaEpigenetic AlterationsOur results show that coordinate epigenetic silencing extends across a large chromosomal region encompassing MLH1 in microsatellite-unstable colorectal cancers.17909015
Primary malignant neoplasmEpigenetic AlterationsSimultaneous epigenetic silencing of this cluster of 3p22 genes may contribute to the development or progression of this type of cancer.17909015
Unknown (origin) (qualifier value), Lupus ErythematosusEpigenetic AlterationsThese results suggest that defective T cell PKCdelta activation may contribute to the development of idiopathic and hydralazine-induced lupus through effects on T cell DNA methylation.17911642
Carcinoma of lungEpigenetic AlterationsGenetic and environmental factors (dietary and smoking) influence lung cancer epidemiology and induce epigenetic modifications that should be assessed in individual populations.17923809
Colorectal Neoplasms, NeoplasmsEpigenetic AlterationsGenetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features.17923875
MAGEC2 geneEpigenetic AlterationsInducible expression of a prostate cancer-testis antigen, SSX-2, following treatment with a DNA methylation inhibitor.17929270
Prostate Cancer PathwayEpigenetic AlterationsIn addition, we report that the treatment of at least two human prostate cancer cell lines with the DNA methylation inhibitor 5-aza-2-deoxycytidine induced the expression of SSX-2.17929270
Colorectal Cancer PathwayEpigenetic AlterationsAssociation between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy.17947473
Carcinoma of lungEpigenetic AlterationsThe epigenetic inactivation of certain genes by aberrant promoter methylation plays an important role in the pathogenesis of lung cancer.17960794
Breast Carcinoma, NeoplasmsEpigenetic AlterationsPITX2 DNA-methylation was measured in tumor tissue from 412 LNN/HR+ breast cancer patients who had not received any adjuvant systemic treatment.17965955
Breast CarcinomaEpigenetic AlterationsIn addition, PITX2 DNA-methylation and mRNA expression was evaluated in 32 breast cancer cell lines.17965955
Breast CarcinomaEpigenetic AlterationsIn the breast cancer cell lines, PITX2 DNA methylation was inversely association with PITX2A and PITX2B mRNA expression (P < 0.01).17965955
Adenocarcinoma of lung (disorder)Epigenetic AlterationsIdentification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma.17967182
Adenocarcinoma, NeoplasmsEpigenetic AlterationsWe identified thirteen loci showing significant differential DNA methylation levels between tumor and non-tumor lung; eight of these show highly significant hypermethylation in adenocarcinoma: CDH13, CDKN2A EX2, CDX2, HOXA1, OPCML, RASSF1, SFPR1, and TWIST1 (p-value << 0.0001).17967182
Adenocarcinoma of lung (disorder), NeoplasmsEpigenetic AlterationsDNA methylation of these loci did not differ significantly based on gender, race, age or tumor stage, indicating their wide applicability as potential lung adenocarcinoma markers.17967182
Adenocarcinoma of lung (disorder), NeoplasmsEpigenetic AlterationsThe four most highly ranked loci, CDKN2A EX2, CDX2, HOXA1 and OPCML, which show significant DNA methylation even in stage IA tumor samples, merit further investigation as some of the most promising lung adenocarcinoma markers identified to date.17967182
CarcinogenesisEpigenetic AlterationsThis could play an important role in carcinogenesis through the degree of DNA methylation and of nucleotide synthesis.17967524
CarcinogenesisEpigenetic AlterationsOur results also suggest that an aberrant DNA methylation pattern, through impaired folate metabolism, might play a key role in gastric carcinogenesis.17972183
Primary malignant neoplasmEpigenetic AlterationsFurther investigation of the role of miRNAs and their regulation in cancer is warranted.17974952
Malignant NeoplasmsEpigenetic AlterationsEvidence has highlighted the role of abnormal DNA methylation patterns on inappropriate gene expression in development and progression of various cancers.17979520
Aggressive behaviorEpigenetic AlterationsNo association of genetic and epigenetic alterations with histological type, tumor aggressiveness, and invasion was found (P > 0.05), which may be attributable to small sample size.17981214
NeoplasmsEpigenetic AlterationsOur findings predict that epigenetic events play a significant role in human tumors that express high levels of c-Myc.17982115
Breast CarcinomaEpigenetic AlterationsThe epigenetic alterations involved in the onset and progression of breast cancer may serve as biomarkers for early detection and prognosis of the disease.17998817
nervous system disorder, Rett Syndrome, Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation of individual genes is a hallmark of cancer and has been shown to play an important role in neurological disorders such as Rett syndrome.17999367
Primary malignant neoplasmEpigenetic AlterationsWe determined the quantitative DNA methylation levels of 1,505 CpG sites representing 807 genes with diverse functions, including proliferation and differentiation, previously shown to be implicated in human cancer.17999367
Malignant neoplasm of lung, NeoplasmsEpigenetic AlterationsLung cancers develop via multiple genetic and epigenetic changes, including inactivation of tumor suppressor genes.18000218
Colorectal Cancer PathwayEpigenetic AlterationsWe have analyzed both genetic (mutations of BRAF, KRAS, and p53 and microsatellite instability) and epigenetic alterations (DNA methylation of 27 CpG island promoter regions) in 97 primary colorectal cancer patients.18003927
Malignant tumor of colonEpigenetic AlterationsUnsupervised hierarchical clustering of the DNA methylation data identified three distinct groups of colon cancers named CpG island methylator phenotype (CIMP) 1, CIMP2, and CIMP negative.18003927
Malignant tumor of colonEpigenetic AlterationsIntegrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.18003927
Malignant tumor of colonEpigenetic AlterationsColon cancer has been viewed as the result of progressive accumulation of genetic and epigenetic abnormalities.18003927
Malignant tumor of colonEpigenetic AlterationsTogether, our integrated genetic and epigenetic analysis reveals that colon cancers correspond to three molecularly distinct subclasses of disease.18003927
CarcinogenesisEpigenetic AlterationsOne of the earliest and most common epigenetic events in prostate carcinogenesis is DNA CpG island (CGI) hypermethylation.18004747
Functional disorderEpigenetic AlterationsCultured human mammary epithelial cells that lack p16(INK4a) activity have been shown to exhibit premalignant phenotypes, such as telomeric dysfunction, centrosomal dysfunction, a sustained stress response, and, most recently, a dysregulation of chromatin remodeling and DNA methylation.18006786
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsThese data suggest that cells that lack p16(INK4a) activity would be at high risk for breast cancer development and may exhibit an increased frequency of DNA methylation events in early cancer.18006786
Malignant Neoplasms, Imprinting (Psychology), Primary malignant neoplasm, AlloisoleucineEpigenetic AlterationsLoss of imprinting (LOI) is a common epigenetic event in cancer and may serve as an early biomarker in some cancers.18006818
CarcinogenesisEpigenetic AlterationsChanges in DNA methylation have been reported to occur early in carcinogenesis and therefore are potentially important early indicators of existing disease.18025318
Primary malignant neoplasmEpigenetic AlterationsThe clinical implications of these genes as diagnostic and treatment biomarkers are highly relevant as attractive targets for cancer therapy, given the reversible nature of epigenetic gene silencing.18025318
NeoplasmsEpigenetic AlterationsTo identify new regions of epigenetic perturbation in WTs, we screened kidney and tumor DNA using CpG island (CGI) tags associated with cancer-specific DNA methylation changes.18030365
Nephroblastoma, NeoplasmsEpigenetic AlterationsWilms tumors (WTs) have a complex etiology, displaying genetic and epigenetic changes, including loss of imprinting (LOI) and tumor suppressor gene silencing.18030365
Acute lymphocytic leukemia, NeoplasmsEpigenetic AlterationsWe have demonstrated that WNT5A, a putative tumour suppressor gene in ALL, is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression and confers poor prognosis in this group of patients.18032022
Prostate Cancer PathwayEpigenetic AlterationsThese findings show that AI at 13q14.2 approximately q14.3 is an important event in the progression of localized prostate cancer, and suggest a possible role for microRNAs.18036398
NCI CTEP SDC Choroid Plexus Tumors Sub-Category TerminologyEpigenetic AlterationsDNA methylation patterns of the CDH1, RARB, and SFN genes in choroid plexus tumors.18036402
Neoplasms, NeuroepithelialEpigenetic AlterationsGenetic and epigenetic alterations in choroid plexus tumors, a rare neuroepithelial neoplasm most frequently detected in children, are poorly characterized.18036402
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsEpigenetic silencing associated with aberrant CpG island methylation is one mechanism leading to the loss of tumor suppressor functions in cancer cells.18036402
DiseaseEpigenetic AlterationsEvidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation and pathogenesis of human diseases.18042587
Lupus Erythematosus, SystemicEpigenetic AlterationsThis work indicates that miRNAs are potential diagnosis biomarkers and probable factors involved in the pathogenesis of SLE.18042587
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsIntegrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations.18048385
Malignant tumor of colonEpigenetic AlterationsEpigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.18054557
Primary malignant neoplasmEpigenetic AlterationsThese results further highlight the applicability of miRNA expression patterns as potential markers of human cancer, and our results suggest that FFPE tissues are suitable resources for such miRNA expression analyses.18058265
Multinodular goiter, Papillary thyroid carcinomaEpigenetic AlterationsDifferential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues.18058265
MethylnitronitrosoguanidineEpigenetic AlterationsWe identified 13 miRNAs upregulated and 26 miRNAs downregulated in PTC versus MNG.18058265
Squamous cell carcinoma of esophagusEpigenetic AlterationsOur results suggest that epigenetic silencing of RUNX3 gene expression by promoter hypermethylation may play an important role in ESCC development.18058463
Gastrointestinal Stromal TumorsEpigenetic AlterationsThe common occurrence of microscopic GISTs compared with the rarity of clinically manifest and malignant esophagogastric GISTs suggests that additional genetic or epigenetic alterations must happen for neoplastic progression.18059218
Prostate Cancer Pathway, CarcinogenesisEpigenetic AlterationsAberrant DNA methylation is a hallmark of carcinogenesis and GSTP1 hypermethylation is the most common molecular alteration in human prostate cancer.18076912
Colorectal CarcinomaEpigenetic AlterationsUtilizing 903 population-based colorectal cancers and real-time PCR (MethyLight), we quantified DNA methylation in WRN and eight other promoters (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1) known to be specific for CIMP.18084250
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation biomarkers for blood-based colorectal cancer screening.18089654
Hodgkin DiseaseEpigenetic AlterationsMicroRNA expression profiling in classic Hodgkin lymphoma.18089852
Communicable Diseases, Hodgkin DiseaseEpigenetic AlterationsWe analyzed miRNA expression in classic Hodgkin lymphoma (cHL) and the influence of Epstein-Barr virus (EBV) infection on the miRNA expression profiles.18089852
Malignant neoplasm of urinary bladderEpigenetic AlterationsA novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer.18094410
Malignant neoplasm of urinary bladderEpigenetic AlterationsInterestingly, the cluster of reported methylation markers used in the U.S. bladder cancers is distinctly different from that identified in this study, suggesting a possible epigenetic disparity between the American and Chinese cases.18094410
Non-Cancer Related Death, CTSG gene, Chronic gastritisEpigenetic AlterationsThese markers were then analyzed in a tester set of 25 paired GC and GCN and 27 chronic gastritis (CG) from non-cancer patients to generate their DNA methylation profiles.18158559
Stomach CarcinomaEpigenetic AlterationsTreatment with the demethylating agent, 5-aza-2-deoxycytidine (5-Aza-dC) resulted in the restoration of REG3A mRNA expression in the gastric cancer cell line, indicating that the transcriptional silencing of REG3A in SNU cell lines was caused by DNA methylation.18160850
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsAberrant DNA methylation is an important epigenetic alteration in hepatocellular carcinoma (HCC).18161048
Hepatitis B, Hepatitis C, InfectionEpigenetic AlterationsMethylation of 19 epigenetic markers was quantified, and the results were correlated with different disease states and the presence or absence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections.18161048
Adenocarcinoma of large intestineEpigenetic AlterationsExtensive genetic and epigenetic analysis of poorly differentiated colorectal adenocarcinomas (Por) has been difficult, as the number of cases is too small.18161865
NeoplasmsEpigenetic AlterationsThe cases of WD were matched with the cases of Por for T classification and tumor location, which influence genetic and epigenetic alterations.18161865
Malignant NeoplasmsEpigenetic AlterationsSystemic inhibition of DNA methylation causes cancers in animals, in part by inducing genetic instability.18166347
Carcinoma of lungEpigenetic AlterationsMicroRNA signature predicts survival and relapse in lung cancer.18167339
Non-Small Cell Lung CarcinomaEpigenetic AlterationsUsing real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets.18167339
Primary malignant neoplasm, Non-Small Cell Lung CarcinomaEpigenetic AlterationsThis microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.18167339
Hollings Cancer CenterEpigenetic AlterationsA total of 15 miRNAs exhibited higher expression in the HCC samples than that in the NT samples, and one miRNA demonstrated lower expression in the HCC samples than in the NT samples.18171346
Disease, Primary malignant neoplasmEpigenetic AlterationsEvidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation, and pathogenesis of human diseases including cancer.18171346
Hollings Cancer CenterEpigenetic AlterationsA total of 18 miRNAs identified valid expression only in HCC samples, with six only in NT samples.18171346
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, NeoplasmsEpigenetic AlterationsTo evaluate aberrant promoter hypermethylation of candidate tumor suppressor genes as a means to detect epigenetic alterations specific to solid tumors, including head and neck squamous cell carcinoma (HNSCC).18172258
Breast CarcinomaEpigenetic AlterationsFolate plays an essential role in DNA methylation and synthesis, and thus may be involved in the development of breast cancer.18174236
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsFurthermore, the 20-miRNA tumor signature was validated in 110 additional cases as a significant independent predictor of survival (P = 0.009) and was significantly associated with both survival and relapse in 89 cases of early stage HCC (P = 0.022 and 0.002, respectively).18176954
Hollings Cancer CenterEpigenetic AlterationsThese 20 miRNAs may provide a simple profiling method to assist in identifying patients with HCC who are likely to develop metastases/recurrence.18176954
Hypertensive diseaseEpigenetic AlterationsEpigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension.18178212
Hypertensive diseaseEpigenetic AlterationsLittle is known, however, of human HSD11B2 epigenetic control and its relationship with the onset of hypertension.18178212
Hypertensive diseaseEpigenetic AlterationsThese results show a clear link between the epigenetic regulation through repression of HSD11B2 in PBMC DNA and hypertension.18178212
Squamous cell carcinoma of esophagusEpigenetic AlterationsTo measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China.18186556
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.18187662
FLT3 Internal Tandem DuplicationEpigenetic AlterationsmiRNA expression was also closely associated with selected cytogenetic and molecular abnormalities, such as t(11q23), isolated trisomy 8, and FLT3-ITD mutations.18187662
FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, AcuteEpigenetic AlterationsIn conclusion, miRNA expression in AML is closely associated with cytogenetics and FLT3-ITD mutations.18187662
Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe identified several miRNAs differentially expressed between CD34(+) normal cells and the AML samples.18187662
Primary malignant neoplasmEpigenetic AlterationsSince gene deregulation is one of the key mechanisms by which cells can progress to cancer, we hypothesize that common polymorphisms within miRNA-target binding sites could play a role in the individual risk of cancer.18192692
Primary malignant neoplasmEpigenetic AlterationsThese results are the first reporting positive association between miRNA-binding SNPs sequences and cancer risk.18192692
Colorectal Cancer PathwayEpigenetic AlterationsPolymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer.18192692
Prostate Cancer PathwayEpigenetic AlterationsDNA methylation has emerged as a promising biomarker for prostate cancer detection.18196513
Clinical CoordinatorEpigenetic AlterationsmiRNA expression levels were also correlated with commonly used clinicopath-ologic features of CRC.18196926
NeoplasmsEpigenetic AlterationsInactivation of tumour-related genes by promoter hypermethylation is a common epigenetic event in the development of a variety of tumours.18211945
Uveal melanoma, melanomaEpigenetic AlterationsAs promoter methylation of APC, RASSF1 and RARB is often observed in cutaneous melanoma, these results suggest that different epigenetic events occur in the development of cutaneous and uveal melanoma.18211945
BehaviorEpigenetic AlterationsHigh activity of histone deacetylases (HDACs) causes epigenetic alterations associated with malignant cell behaviour.18212746
Clinical Observations Supplemental Qualifiers DatasetEpigenetic AlterationsBoth show ubiquitous inactivation of TP53 (pPCL 56%; sPCL 83%) by coding mutation or 17p13 deletion; complemented by p14ARF epigenetic silencing in sPCL (29%).18216867
Malignant neoplasm of esophagusEpigenetic AlterationsFurthermore, GNG7-transfected oesophageal cancer cells were analysed in laboratory studies at genomic and epigenetic levels.18219292
Malignant neoplasm of esophagusEpigenetic AlterationsIn addition, GNG7 expression was significantly associated with the presence of miR328 in oesophageal cancer cell lines, which suggests that this microRNA might be a regulator of GNG7 expression.18219292
Adenocarcinoma of colonEpigenetic AlterationsMicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.18230780
Adenocarcinoma of colonEpigenetic AlterationsTo identify microRNA expression patterns associated with colon adenocarcinomas, prognosis, or therapeutic outcome.18230780
Neoplasms, Adenocarcinoma of colonEpigenetic AlterationsMicroRNA microarray expression profiling of tumors and paired nontumorous tissues was performed on a US test cohort of 84 patients with incident colon adenocarcinoma, recruited between 1993 and 2002.18230780
Neoplasms, Cessation of lifeEpigenetic AlterationsMicroRNAs that were differentially expressed in tumors and microRNA expression patterns associated with survival using cancer-specific death as the end point.18230780
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs have potential as diagnostic biomarkers and therapeutic targets in cancer.18230780
NeoplasmsEpigenetic AlterationsRESULTS Thirty-seven microRNAs were differentially expressed in tumors from the test cohort.18230780
Adenocarcinoma of colonEpigenetic AlterationsExpression patterns of microRNAs are systematically altered in colon adenocarcinomas.18230780
Alzheimers DiseaseEpigenetic AlterationsThe expression of microRNA miR-107 decreases early in Alzheimers disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.18234899
Childhood Leukemia, Primary malignant neoplasmEpigenetic AlterationsEpigenetic modulation of gene expression plays an important role in cancer, including leukemia.18245545
UROD wt AlleleEpigenetic AlterationsUPD was detected in 4 samples; 2 samples involved whole chromosome 13 resulting in homozygous deletion of micro-RNA-15a (miR-15a)/miR-16-1.18246537
Agenesis of corpus callosumEpigenetic AlterationsCell cycle disruption induced by these epigenetic aberrations might be important in the tumorigenesis of ACC.18254776
Squamous cell carcinoma of the head and neckEpigenetic Alterationsp16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas.18261630
Colorectal CarcinomaEpigenetic AlterationsIn vitro study found elevated KLF4 mRNA expression in SW620 and RKO cells with 5-aza-dC treatment, implicating the underlying aberrant epigenetic modifications in regulating KLF4 expression at least in a subset of colorectal cancers.18264726
Adenoma of large intestine, Malignant NeoplasmsEpigenetic AlterationsKLF4 is associated with terminal differentiation in colorectal epithelium and drastically downregulated in colorectal adenomas and cancers via possible epigenetic modifications.18264726
CarcinogenesisEpigenetic AlterationsDisturbances in DNA methylation are a characteristic of colorectal carcinogenesis.18268116
CarcinogenesisEpigenetic AlterationsThese gene-diet interactions suggest that polymorphisms relevant to DNA methylation or alcohol metabolism may play a role in colorectal carcinogenesis in conjunction with a high-risk diet.18268116
Thyroid NeoplasmEpigenetic AlterationsMicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility.18270258
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miRNA) expression is deregulated in many types of human cancers.18270258
Thyroid NeoplasmEpigenetic AlterationsVarious histopathological types of thyroid tumors, including those deriving from the same cell type, showed significantly different profiles of miRNA expression.18270258
Carcinoma, PapillaryEpigenetic AlterationsSignificant correlation between miRNA expression patterns and somatic mutations was observed in papillary carcinomas.18270258
Gastrointestinal Stromal TumorsEpigenetic AlterationsAberrant DNA methylation of these loci was found in 94% of all GIST.18271923
Glioma, NeoplasmsEpigenetic AlterationsTherefore, we conclude that the tumor suppressor role of PAX6, reported in previous studies on gliomas, is not due to mutation in its coding and regulating regions, suggesting the involvement of epigenetic mechanisms in the silencing of PAX6 in these tumors.18273794
CarcinogenesisEpigenetic AlterationsIt is possible that endogenous 8-oxo-7,8-dihydroguanine (8-oxoGua) level may be linked to aberrant DNA methylation of adjacent cytosine and in this way influences carcinogenesis.18281064
CarcinogenesisEpigenetic AlterationsOur work provides the first in vivo evidence suggesting that increased levels of 8-oxodG in DNA may lead to carcinogenesis not only via mispair/mutagenic potential of the modified base but also through its ability to influence gene expression by affecting DNA methylation.18281064
Stomach CarcinomaEpigenetic AlterationsEpigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion.18283041
Stomach Carcinoma, MetastasisEpigenetic AlterationsBased on these results, we propose that PKD1 is frequently silenced by epigenetic regulation, which plays a role in cell migration and metastasis in gastric cancer.18283041
Malignant Head and Neck NeoplasmEpigenetic AlterationsLoss of interferon-gamma inducibility of the MHC class II antigen processing pathway in head and neck cancer: evidence for post-transcriptional as well as epigenetic regulation.18284388
CarcinogenesisEpigenetic AlterationsIncreased expression of Cx32 in metastases to the lymph nodes might reflect alteration in connexin gene transcription during breast carcinogenesis and finally, it may be a sign of more malignant phenotype of cancerous cells.18292829
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe etiology of esophageal squamous cell carcinoma (ESCC) has been shown to be multifactorial, including genetic, epigenetic, and environmental factors, such as tobacco smoking.18294291
Penis carcinomaEpigenetic AlterationsHowever, so far, only a few studies have searched for DNA methylation in penile carcinoma (PC).18299890
Squamous Cell Carcinoma of the PenisEpigenetic AlterationsFrequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas.18299890
Hepatitis C Virus-Related Hepatocellular CarcinomaEpigenetic AlterationsMicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma.18307259
CarcinogenesisEpigenetic AlterationsMany fundamental biological processes are modulated by microRNAs, and an important role for microRNAs in carcinogenesis is emerging.18307259
Primary Neoplasm, NeoplasmsEpigenetic AlterationsA subset of microRNAs are aberrantly expressed in primary liver tumors, serving both as putative tumor suppressors and as oncogenic regulators.18307259
septicEpigenetic AlterationsConsequently, septic neutrophils are promptly responsive to IL-10 in vitro, as revealed by a direct IL-10-mediated induction of STAT3 tyrosine phosphorylation and SOCS-3 gene transcription, mRNA and protein expression.18308712
Hematopoietic NeoplasmsEpigenetic AlterationsRecent studies have suggested that menin may act as a scaffold protein to coordinate gene transcription, and that menin is an oncogenic cofactor for homeobox (HOX) gene expression in hematopoietic cancer.18310293
Stomach CarcinomaEpigenetic AlterationsEpigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion.18314483
Malignant neoplasm of penisEpigenetic AlterationsIn summary, the epigenetic inactivation of TSP-1 and RASSF1-A genes is associated with pathological variables and seems to be of prognostic significance in penile cancer.18336597
Carcinoma of lungEpigenetic AlterationsDNA methylation markers and early recurrence in stage I lung cancer.18337602
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsThe positive associations between folate intake and tumors harboring BRAF mutations and between vitamin B6 intake and those showing MLH1 hypermethylation were most pronounced among men and may suggest that these vitamins enhance colorectal cancer risk through genetic as well as epigenetic aberrations.18339680
Primary Neoplasm, NeoplasmsEpigenetic AlterationsThis epigenetic event may lead to progressive silencing of tumor suppressor genes, including RUNX3, in these epithelial cells, which also occurred in primary breast tumors.18339859
Carcinogenesis, NeoplasmsEpigenetic AlterationsThe high prevalence of estrogen-induced epigenetic changes in primary tumors and the surrounding histologically normal tissues provides the first empirical link between estrogen injury of breast stem/progenitor cells and carcinogenesis.18339859
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThis finding also offers a mechanistic explanation as to why a tumor suppressor gene, such as RUNX3, can be heritably silenced by epigenetic mechanisms in breast cancer.18339859
Breast CarcinomaEpigenetic AlterationsThe pathogenesis of breast cancer involves multiple genetic and epigenetic events.18346456
Breast CarcinomaEpigenetic AlterationsIn this study, we report an epigenetic alteration of DFNA5 in human breast cancer.18346456
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsDNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients.18349282
Hollings Cancer CenterEpigenetic AlterationsThis indicates that these epigenetic events may serve as a good marker for HCC.18351580
Lewy Body Disease, DementiaEpigenetic AlterationsIt suggested that epigenetic methylation of circadian gene was more prevalent in dementia patients, especially for the DLB patients.18358604
Squamous cell carcinoma of esophagusEpigenetic AlterationsDNA methylation and loss of protein expression in esophageal squamous cell carcinogenesis of high-risk area.18365557
Colorectal CarcinomaEpigenetic AlterationsUtilizing 869 population-based colorectal cancers, we measured long interspersed nucleotide element-1 (LINE-1) methylation level by Pyrosequencing, which correlates with global DNA methylation level.18366060
SF3B1 wt Allele, Neoplasms, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsThe epigenetic changes of tumor suppressor genes (TSG) are now recognized as an abnormal mechanism contributing to the development of myelodysplastic syndrome (MDS).18367246
Dermatologic disorders, PsoriasisEpigenetic AlterationsAlteration of the p16INK4a gene by epigenetic changes has been described in some hyperproliferative skin diseases, but its importance in psoriasis has not yet been established.18373711
Breast CarcinomaEpigenetic AlterationsCo-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy.18377693
NeoplasmsEpigenetic AlterationsAn increase in DNA repair enzymes and disappearance of DNA methylation patterns attributes to reduction in tumour burden and may suggest good prognosis and efficacy of the treatment.18377693
Malignant NeoplasmsEpigenetic AlterationsBoth genetic (mutations, deletions, chromosomal rearrangements) and epigenetic (aberrant methylation of the 5CpG island) alterations of the FHIT gene have been reported in various malignancies.18378390
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsEpigenetic changes play an important role in cancer pathogenesis through transcriptional silencing of critical tumor suppressor genes.18385750
Aggressive behaviorEpigenetic AlterationsEffect of DNA methylation on identification of aggressive prostate cancer.18387661
Malignant NeoplasmsEpigenetic AlterationsDNA methylation of promoter regions leads to gene silencing in many cancers.18387661
Stomach CarcinomaEpigenetic AlterationsDetection of DNA methylation in serum may be a biomarker for early detection of gastric cancer.18395906
NeoplasmsEpigenetic AlterationsHaving previously assessed relative methylation in blood-derived DNA, we compared tumor with the blood DNA methylation level and observed these to be independent.18398038
Aggressive behaviorEpigenetic AlterationsThese findings suggest that HPV-associated tumors differ molecularly from those arising after heavy tobacco use and that this epigenetic alteration may affect survival in HPV-negative patients already exhibiting a more aggressive disease.18398038
cervical cancerEpigenetic AlterationsIdentification of novel DNA methylation markers in cervical cancer.18398837
Primary malignant neoplasmEpigenetic AlterationsTesting for DNA methylation has potential in cancer screening.18398837
cervical cancerEpigenetic AlterationsMost previous studies of DNA methylation in cervical cancer used a candidate gene approach.18398837
cervical cancerEpigenetic AlterationsThe analysis of these novel DNA methylations may be a promising approach for the screening of cervical cancers.18398837
Colorectal CarcinomaEpigenetic AlterationsAnother hypermethylation pattern found in colorectal cancers, termed long-range epigenetic silencing, is associated with DNA/histone methylation in three distinct gene clusters at chromosome 2q14.2, showing that DNA hypermethylation can span larger chromosomal domains and lead to the silencing of flanking, unmethylated genes.18403637
Colorectal Cancer PathwayEpigenetic AlterationsThe CpG island methylator phenotype correlates with long-range epigenetic silencing in colorectal cancer.18403637
Kidney Failure, Acute, Adenocarcinoma Of EsophagusEpigenetic AlterationsThe results suggest that silencing of ARF is involved in the pathogenesis of oesophageal adenocarcinoma and show that either DNA or histone methylation can provide the primary mechanism for ARF gene silencing.18410530
Liver neoplasmsEpigenetic AlterationsThrough comparison of RNA polymerase II binding, chromatin structure, DNA methylation, and copy number changes, we suggest that the major contributor to creation of the liver tumor transcriptome was changes in gene copy number.18413731
Acute Myeloid Leukemia Arising from Previous Myelodysplastic SyndromeEpigenetic AlterationsDespite this, pursuing DNMT1 down-regulation remains a sound approach for targeting aberrant epigenetics in AML/MDS.18413836
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetic silencing via aberrant promoter DNA hypermethylation of normal genes has been described as a leukemogenic mechanism in myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML).18413836
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe abnormality of DNA methylation is involved in tumour progression, and thus has a modulating effect on clinical outcome of cancer patients.18414412
Colorectal NeoplasmsEpigenetic AlterationsIn most colorectal tumours, APC mutation stabilises beta-catenin and mimics elements of Wnt growth factor signalling, but the high frequency of epigenetic loss of Wnt antagonists indicates an additional role for ligand-mediated Wnt signalling.18414471
Antigen-Presenting Cells, APC wt AlleleEpigenetic AlterationsIndividual steps in the tumorigenesis pathway, that is, adenomatosis polyposis coli (APC), Wnt-activated, base excision repair mutations, mismatch repair defects, RAF-mediated, transforming growth factor (TGF)-beta-suppressed, bone morphogenic protein (BMP)-suppressed, and p53 alterations, were examined in terms of genetic and epigenetic changes, as well as protein expression.18422752
Malignant Neoplasms, Malignant neoplasm of stomachEpigenetic AlterationsMalignant tumours of the stomach are common, but the incidence of stomach cancer varies from country to country, probably a result of genetic, epigenetic and environmental factors.18424576
Primary malignant neoplasmEpigenetic AlterationsSeveral miRNAs play crucial roles in cancer cell growth.18429962
Stomach CarcinomaEpigenetic AlterationsIn vivo, an inverse relationship between expression of the EZH2 and RUNX3 proteins was observed at the individual cell level in gastric cancer patients in the absence of DNA methylation in the RUNX3 promoter region.18430739
Clinical Coordinator, Lynch SyndromeEpigenetic AlterationsAdditionally, aberrant DNA methylation is a common event not only in sporadic CRC but also in Lynch syndrome CRCs.18435933
Colorectal CarcinomaEpigenetic AlterationsColorectal cancers (CRCs) with the CpG island methylator phenotype (CIMP) often associate with epigenetic silencing of hMLH1 and an activating mutation in the BRAF gene.18435933
Adenocarcinoma of pancreasEpigenetic AlterationsFew genetic mutations have been identified in pancreatic adenocarcinoma, whereas epigenetic changes that lead to gene silencing are known in several genes.18437076
Malignant Neoplasms, Pancreatic carcinoma, NeoplasmsEpigenetic AlterationsBecause SLC5A8 is regarded as a potential tumor suppressor gene that is down-regulated by epigenetic changes in several other cancers, we sought to characterize promoter methylation status and its relationship to SLC5A8 expression in pancreatic cancer.18437076
Pancreatic carcinoma, Carcinogenesis, NeoplasmsEpigenetic AlterationsWe suggest that SLC5A8 may function as a tumor suppressor gene whose silencing by epigenetic changes may contribute to carcinogenesis and progression of pancreatic cancer.18437076
Autoimmune stateEpigenetic AlterationsEpigenetic changes in gene expression, including DNA methylation and histone modifications, might contribute to autoimmunity.18437543
DiseaseEpigenetic AlterationsSeveral microRNA, which are approximately 22-nucleotide noncoding RNAs, exhibit tissue-specific or developmental stage-specific expression patterns and are associated with human diseases.18438844
Rheumatoid ArthritisEpigenetic AlterationsExpression of microRNA-146 in rheumatoid arthritis synovial tissue.18438844
ovarian neoplasmEpigenetic AlterationsComponents of the miRNA processing machinery, such as Dicer and Drosha are not responsible for miRNA deregulation in recurrent ovarian cancer, as deluded by TaqMan and immunohistochemistry.18442408
ovarian neoplasmEpigenetic AlterationsWe propose a miRNA model for the molecular pathogenesis of recurrent ovarian cancer.18442408
ovarian neoplasmEpigenetic AlterationsBased on integrated transcriptome and miRNA analysis, miR-9 and miR-223 can be of potential importance as biomarkers in recurrent ovarian cancer.18442408
Cervix carcinomaEpigenetic AlterationsAltered MicroRNA expression in cervical carcinomas.18451214
Malignant NeoplasmsEpigenetic AlterationsEmerging evidence suggests that miRNAs might be involved in the pathogenesis of a variety of human cancers.18451214
MetastasisEpigenetic AlterationsWhen we analyzed the expression of the 10 most significant miRNAs in 31 ISCCs, increased miR-127 expression was significantly associated with lymph node metastasis (P = 0.006).18451214
Colorectal CarcinomaEpigenetic AlterationsEpigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.18451217
Adenomatous Polyposis ColiEpigenetic AlterationsEarly events in colorectal tumorigenesis include mutation of the adenomatous polyposis coli (APC) gene and epigenetic hypermethylation with transcriptional silencing of the O(6)-methylguanine DNA methyltransferase (MGMT), human mut L homologue 1 (hMLH1), and P16/CDKN2A genes.18451217
NeoplasmsEpigenetic AlterationsOur findings suggest that the heterogeneous epigenetic dysregulation of promoter methylation in various genes is interrelated with the occurrence of mutations, as manifested in epigenetic-genetic subgroups of tumors.18451217
palladiumEpigenetic AlterationsFor selected transcripts, transcriptional alterations were confirmed with qPCR on a larger set of seven PD cases and seven matched controls.18462474
Squamous cell carcinomaEpigenetic AlterationsIdentification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling.18464261
Squamous cell carcinomaEpigenetic AlterationsCurrently, there is no information concerning miRNA expression and functions in squamous cell carcinoma (SCC) of tongue.18464261
Glioblastoma MultiformeEpigenetic AlterationsFurthermore, in 3 out of 4 available H1/H2alpha heterozygous human glioblastoma cell lines, H1-derived mRNA levels were more than 10-fold lower than from H2alpha, resulting at least in part from haplotype-specific epigenetic differences such as DNA methylation and histone acetylation.18464291
SF3B1 wt Allele, TetraploidyEpigenetic AlterationsOur data suggest that the unique complex abnormality of tetraploidy and 5q deletion described here for the first time in MDS is characterized by distinct disease etiology, the mechanism of which could involve epigenetic inactivation of gene expression via methylation.18474300
Pancreatic carcinomaEpigenetic AlterationsAdverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer.18475302
Pancreatic carcinomaEpigenetic AlterationsTherefore, we examined genetic and epigenetic alterations of RUNX3 in human pancreatic cancer.18475302
NeoplasmsEpigenetic AlterationsTumors readily clustered based on miRNA expression into two groups that corresponded to the gene expression-based subtypes: class 1 (low metastatic risk) and class 2 (high metastatic risk).18477892
NeoplasmsEpigenetic AlterationsA classifier that included the top six miRNA discriminators accurately distinguished class 1 from class 2 tumors with 100% sensitivity and specificity.18477892
Uveal melanomaEpigenetic AlterationsmiRNA expression may represent a highly accurate biomarker for metastatic risk in uveal melanoma.18477892
NeoplasmsEpigenetic AlterationsIn addition, these results may provide new insights into the role of miRNAs in tumor progression and the metastatic phenotype.18477892
Uveal melanoma, MetastasisEpigenetic AlterationsMicro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling.18477892
ovarian neoplasmEpigenetic AlterationsHOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer.18478570
Malignant neoplasm of ovary, ovarian neoplasmEpigenetic AlterationsTo identify potential, prognostic DNA methylation markers in ovarian cancer we analyzed the DNA methylation at 71 different loci in 22 ovarian cancers and 18 non-neoplastic ovarian specimens by means of a quantitative, real-time PCR-based technique (MethyLight).18478570
Primary malignant neoplasmEpigenetic AlterationsWe identified DNA methylation of HOXA10 and HOXA11, both of them PcGTs, to be the best discriminators between cancer and non-neoplastic tissue.18478570
ovarian neoplasm, NeoplasmsEpigenetic AlterationsIn an independent set consisting of 92 ovarian cancer specimens further analysis demonstrated that HOXA11 DNA methylation is (i) strongly associated with the residual tumor after cytoreductive surgery and (ii) is a marker indicating poor prognosis.18478570
Cessation of lifeEpigenetic AlterationsHOXA11 DNA methylation was independently associated with poor outcome [relative risk for death 3.4 (95% CI 1.2-9.9; p = 0.03)].18478570
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations play a major role in cancer.18478570
Breast CarcinomaEpigenetic AlterationsDNA methylation in benign breast epithelium in relation to age and breast cancer risk.18483325
Multiple MyelomaEpigenetic AlterationsEpigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival.18483358
Stomach CarcinomaEpigenetic AlterationsEpigenetic changes in a group of glycosyltransferases including B4GALNT2 and ST3GAL6 represent a malignant phenotype of gastric cancer caused by silencing of the activity of these enzymes, which action may eventually induce aberrant glycosylation and expression of cancer-associated carbohydrate antigens.18485915
Primary malignant neoplasmEpigenetic AlterationsAccumulation of genetic and epigenetic alterations contribute to malignant transformation of normal colonic mucosa to cancer.18486467
CarcinogenesisEpigenetic AlterationsMBD4 (methyl-CpG binding domain protein 4) was identified as a methyl-CpG binding protein and plays an important role in DNA methylation and carcinogenesis.18495292
Squamous cell carcinomaEpigenetic AlterationsEpigenetic inactivation of SFRP genes in oral squamous cell carcinoma.18497987
Malignant neoplasm of ovary, ovarian neoplasmEpigenetic AlterationsTo explore the potential role of DNA methylation on HLA-G expression in ovarian cancer, we correlated differences in HLA-G expression with methylation changes within the HLA-G regulatory region in an ovarian cancer cell line treated with 5-aza-deoxycytidine (5-aza-dC) and in malignant and benign ovarian tumor samples and ovarian surface epithelial cells (OSE) isolated from patients with normal ovaries.18498645
ovarian neoplasmEpigenetic AlterationsEpigenetic changes within the promoter region of the HLA-G gene in ovarian tumors.18498645
NeoplasmsEpigenetic AlterationsPrevious findings have suggested that epigenetic-mediated HLA-G expression in tumor cells may be associated with resistance to host immunosurveillance.18498645
NeoplasmsEpigenetic AlterationsThere was no correlation between DNA methylation and E-cadherin protein levels in either tumors or matched normal tissues.18503162
Primary malignant neoplasmEpigenetic AlterationsThe identification of target mRNAs is a key step for assessing the role of aberrantly expressed microRNAs in human cancer.18521080
NeoplasmsEpigenetic AlterationsRecent evidence indicates that small noncoding RNA molecules known as microRNAs (miRNAs) can function as tumor suppressors and oncogenes.18521189
Non-Small Cell Lung CarcinomaEpigenetic AlterationsGenetic variants of miRNA sequences and non-small cell lung cancer survival.18521189
Carcinogenesis, NeoplasmsEpigenetic AlterationsMutation, misexpression, and altered mature miRNA processing are implicated in carcinogenesis and tumor progression.18521189
Non-Small Cell Lung CarcinomaEpigenetic AlterationsBecause SNPs in pre-miRNAs could alter miRNA processing, expression, and/or binding to target mRNA, we conducted a systematic survey of common pre-miRNA SNPs and their surrounding regions and evaluated in detail the association of 4 of these SNPs with the survival of individuals with non-small cell lung cancer (NSCLC).18521189
Carcinoma of lungEpigenetic AlterationsIn the genotype-phenotype correlation analysis of 23 human lung cancer tissue samples, rs11614913 CC was associated with a statistically significant increase in mature hsa-mir-196a expression but not with changes in levels of the precursor, suggesting enhanced processing of the pre-miRNA to its mature form.18521189
Primary malignant neoplasmEpigenetic AlterationsFurther characterization of miRNA SNPs may open new avenues for the study of cancer and therapeutic interventions.18521189
NeoplasmsEpigenetic AlterationsIn addition, we have analyzed the expression of five micro RNAs located within the 17q23.2-q25.3 region, but none of them showed high expression levels compared to the benign tumors.18522746
Alzheimers DiseaseEpigenetic AlterationsIdentification of miRNA changes in Alzheimers disease brain and CSF yields putative biomarkers and insights into disease pathways.18525125
Admitting diagnosisEpigenetic AlterationsUsing a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains.18525125
Admitting diagnosis, "Alzheimers Disease", Neurodegenerative DisordersEpigenetic AlterationsMicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimers disease (AD) is unknown.18525125
Admitting diagnosisEpigenetic AlterationsWe used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity.18525125
Idiopathic Interstitial PneumoniasEpigenetic AlterationsAssessment of gene transcription demonstrates connection with the clinical course of idiopathic interstitial pneumonia.18525195
Malignant NeoplasmsEpigenetic AlterationsMany genes undergo aberrant methylation in human cancers, and microarray platforms enable more comprehensive profiling of aberrant DNA methylation patterns.18535405
Pancreatic carcinomaEpigenetic AlterationsWe used methylated CpG island amplification (MCA) and Agilent promoter and CpG island microarrays to identify differential DNA methylation patterns in pancreatic cancer vs. normal pancreas.18535405
Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia.18537968
Leukemia, Myelocytic, AcuteEpigenetic AlterationsTo analyse epigenetic dysregulation of SFRPs in acute myeloid leukaemia (AML), we examined the promoter methylation status of SFRP1, -2, -4 and -5 in AML cell lines by methylation-specific polymerase chain reaction (MSP).18537968
Lymphoma, Follicular, LymphomaEpigenetic AlterationsMicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas.18537969
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNA, miR) are negative regulators of gene expression that play an important role in diverse biological processes such as development, cell growth, apoptosis and haematopoiesis, suggesting their association with cancer.18537969
Lymphoma, Follicular, Diffuse Large B-Cell LymphomaEpigenetic AlterationsHere we analysed the expression signatures of 157 miRNAs in 58 diffuse large B-cell lymphoma (DLBCL), 46 follicular lymphoma (FL) and seven non-neoplastic lymph nodes (LN).18537969
NeoplasmsEpigenetic AlterationsComparison of the possible combinations of DLBCL-, FL- and LN resulted in specific DLBCL- and FL-signatures, which include miRNAs with previously published function in haematopoiesis (MIRN150 and MIRN155) or tumour development (MIRN210, MIRN10A, MIRN17-5P and MIRN145).18537969
LymphomaEpigenetic AlterationsAs compared to LN, some miRNAs are differentially regulated in both lymphoma types (MIRN155, MIRN210, MIRN106A, MIRN149 and MIRN139).18537969
Diffuse Large B-Cell LymphomaEpigenetic AlterationsConversely, some miRNAs show lymphoma-specific aberrant expression, such as MIRN9/9*, MIRN301, MIRN338 and MIRN213 in FL and MIRN150, MIRN17-5P, MIRN145, MIRN328 and others in DLBCL.18537969
Diffuse Large B-Cell Lymphoma, NeoplasmsEpigenetic AlterationsFinally, eight miRNAs were found to correlate with event-free and overall survival in DLBCL including known tumour suppressors (MIRN21, MIRN127 and MIRN34a) and oncogenes (MIRN195 and MIRNLET7G).18537969
Breast CarcinomaEpigenetic AlterationsFurther, the interactions between DNA methylation and hormone receptor biology in breast cancer cells are beginning to be clearly understood.18538349
Primary malignant neoplasmEpigenetic AlterationsEpigenetic markers, in particular, those based on aberrant DNA methylation, can be used to diagnose cancer.18541613
NeoplasmsEpigenetic AlterationsNo correlation was found between DNA methylation of BAGE loci and age, gender of patients, nor with the tumor stage or site.18541613
Malignant tumor of colonEpigenetic AlterationsBAGE hypomethylation, a new epigenetic biomarker for colon cancer detection.18541613
Malignant tumor of colonEpigenetic AlterationsThese new markers enrich the list of currently studied epigenetic alterations in colon cancer and could be associated with hypermethylation markers to develop reliable diagnostic tests.18541613
Neoplastic diseaseEpigenetic AlterationsThe apparently normal mucosal field of patients presenting with neoplasia has evidently undergone significant epigenetic modification.18542073
Malignant Neoplasms, Gallbladder Carcinoma, Chronic cholecystitis, CarcinomaEpigenetic AlterationsIn order to determine the potential role of promoter methylation in gallbladder carcinogenesis, we investigated the frequency of this epigenetic mechanism by methylation-specific polymerase chain reaction (MSP) in 35 chronic cholecystitis (CC, separated according to the presence or absence of metaplasia), 19 early cancers (mucosa or muscularis propia invasion) and 48 advanced carcinomas with invasion of the gallbladder subserosa (25 cases) and serosa (23 cases).18543280
Hepatocarcinogenesis, Hollings Cancer CenterEpigenetic AlterationsTo gain insight into the role of epigenetic aberration of telomerase-related genes in hepatocarcinogenesis, we determined a hypermethylation profile in HCC.18546260
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1Epigenetic AlterationsAbnormal DNA methylation of promoter-associated CpG islands in the Wnt signaling pathway is very common in Philadelphia chromosome-positive acute lymphoblastic leukemia and potentially defines subgroups with distinct clinical characteristics.18549404
Breast CarcinomaEpigenetic AlterationsPolymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker.18550570
Liver carcinomaEpigenetic AlterationsGenetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells.18553387
Liver carcinomaEpigenetic AlterationsMicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1.18555017
NeoplasmsEpigenetic AlterationsSpecific microRNA (miR)-223 and miR-222 deregulations were verified in an independent series of tumors.18555017
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsIn hepatocellular carcinoma (HCC), information on differentially expressed miRNA remained largely undefined.18555017
Hepatitis B, Hepatitis C, Hollings Cancer CenterEpigenetic AlterationsArray-based miRNA profiling was performed on HCC cells that were derived from chronic carriers of hepatitis B virus (HBV) and hepatitis C virus (HCV), and nonviral-associated patients.18555017
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsEpigenetic signatures of familial cancer are characteristic of tumor type and family category.18559504
Malignant Neoplasms, Colorectal Carcinoma, Clinical CoordinatorEpigenetic AlterationsAlthough sporadic cancers, especially colorectal carcinoma (CRC), have been characterized for epigenetic changes extensively, such information in familial/hereditary cancer is limited.18559504
Prostate Cancer PathwayEpigenetic AlterationsReactivation of SSBP2 expression by the demethylating agent 5-aza-2-deoxycytidine in prostate cancer cell lines confirmed epigenetic inactivation as one major mechanism of SSBP2 regulation.18559593
Liver carcinomaEpigenetic AlterationsDown-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma.18559595
ABCB1 wt AlleleEpigenetic AlterationsIn conclusion, epigenetic silencing of CXCL12 is a frequent event in NSCLCs, and could be an independent and powerful prognostic marker in patients with NSCLCs and those with stage I disease.18575756
Adenocarcinoma of large intestineEpigenetic AlterationsCdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.18575765
Alzheimers DiseaseEpigenetic AlterationsExpression of a noncoding RNA is elevated in Alzheimers disease and drives rapid feed-forward regulation of beta-secretase.18587408
Alzheimers DiseaseEpigenetic AlterationsThese data show that BACE1 mRNA expression is under the control of a regulatory noncoding RNA that may drive Alzheimers disease-associated pathophysiology.18587408
Alzheimers DiseaseEpigenetic AlterationsIn summary, we report that a long noncoding RNA is directly implicated in the increased abundance of Abeta 1-42 in Alzheimers disease.18587408
Breast CarcinomaEpigenetic AlterationsMultiple mechanisms involved in altering ERalpha gene expression in breast cancer have been identified, including ERalpha gene amplification as well as transcriptional silencing by DNA methylation of CpG islands within the ERalpha promoter and mutations within the open reading frame of ERalpha.18593897
Malignant Neoplasms, Breast CarcinomaEpigenetic AlterationsRecent evidence has shown that microRNA mutations or misexpression correlate with various human cancers, and miR-206 is reported to decrease endogenous ERalpha mRNA and protein levels in human MCF-7 breast cancer cells via two specific target sites within the 3-untranslated region of the human ERalpha transcript.18593897
Malignant NeoplasmsEpigenetic AlterationsThe concordant methylation is possibly a consequence of a long-range epigenetic effect in this region of chromosome 3p, which has recently been described in other cancers.18594535
Malignant neoplasm of stomachEpigenetic AlterationsGenetic and epigenetic analysis of the VHL gene in gastric cancers.18607865
Malignant neoplasm of stomachEpigenetic AlterationsThis is the first investigation of the genetic and epigenetic alterations of the VHL gene in gastric cancers.18607865
Malignant neoplasm of stomachEpigenetic AlterationsOur results suggest that genetic and epigenetic alterations of the VHL gene may be not involved in the development or progression of gastric cancers.18607865
Malignant neoplasm of liver, Hollings Cancer Center, NeoplasmsEpigenetic AlterationsOur current observations provide evidences that ARHI downregulated in HCCs could play a role in liver cancer via acting as a tumor suppressor gene, which mainly was triggered by the epigenetic events in HCC specimens.18612997
Coronary Artery DiseaseEpigenetic AlterationsDetection of altered global DNA methylation in coronary artery disease patients.18613790
ArteriosclerosisEpigenetic AlterationsEpigenetic modifications, especially alteration in DNA methylation, are increasingly being recognized as a key factor in the pathogenesis of complex disorders, including atherosclerosis.18613790
Cardiovascular DiseasesEpigenetic AlterationsThe alteration in genomic DNA methylation associated with cardiovascular disease per se appears to be further accentuated by higher homocysteine levels.18613790
Coronary Artery DiseaseEpigenetic AlterationsHowever, there are limited data on the epigenetic changes in the coronary artery disease (CAD) patients.18613790
Diarrhea, Irritable Bowel SyndromeEpigenetic AlterationsFirst evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome.18614545
Malignant tumor of colonEpigenetic AlterationsThe MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer.18615680
Squamous cell carcinoma of lungEpigenetic AlterationsIdentification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer.18616821
Squamous cell carcinoma of lungEpigenetic AlterationsHere we focused on developing DNA methylation markers for squamous cell carcinoma of the lung.18616821
Squamous cell carcinoma of lungEpigenetic AlterationsWe have identified 22 DNA methylation markers for squamous cell lung cancer, several of which have not previously been reported to be methylated in any type of human cancer.18616821
Squamous cell carcinoma of lungEpigenetic AlterationsThe top eight markers show great promise as a sensitive and specific DNA methylation marker panel for squamous cell lung cancer.18616821
Colorectal CarcinomaEpigenetic AlterationsRedundant DNA methylation in colorectal cancers of Lynch-syndrome patients.18618713
HereditaryEpigenetic AlterationsThe rather randomly distributed weak methylation patterns in hereditary CRCs indicate that epigenetic events are redundant in Lynch-syndrome etiology, in contrast to the widespread DNA methylation in sporadic unstable CRCs.18618713
Malignant NeoplasmsEpigenetic AlterationsLoss of genomic imprinting is an epigenetic alteration of some cancers involving the absence of parental origin-specific expression of imprinted genes.18619647
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsMany tumor genes are inactivated by DNA methylation in gastric cancer.18622497
Myeloproliferative diseaseEpigenetic AlterationsEpigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases.18623127
NeoplasmsEpigenetic AlterationsMEG3 is an imprinted gene encoding a novel noncoding RNA that suppresses tumor cell growth.18628527
Loading TechniqueEpigenetic AlterationsWe propose that epigenetic drift is likely to be a substantial mechanism predisposing individuals to LOAD and contributing to the course of disease.18628954
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsTwo alterations in the pattern of DNA methylation in breast cancer (BC) have been previously reported; active estrogen receptor-alpha (ER-alpha) is associated with decreased methylation of ER-alpha target (ERT) genes, and polycomb group target (PCGT) genes are more likely than other genes to have promoter DNA hypermethylation in cancer.18628976
Chronic diseaseEpigenetic AlterationsFurther research will need to demonstrate whether DNA methylation profiles will be able to serve as a new tool to predict the risk of developing chronic diseases with sufficient accuracy to guide preventive measures.18628976
CarcinogenesisEpigenetic AlterationsEpigenetic changes are emerging as one of the most important events in carcinogenesis.18628976
NeoplasmsEpigenetic AlterationsBased on these results, we propose that the observed frequent epigenetic-mediated TCF4 silencing plays a role in tumor formation and progression.18635522
Prostate Cancer PathwayEpigenetic AlterationsExpression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.18637271
Malignant neoplasm of prostateEpigenetic AlterationsLike EZH2 expression, DNA methylation alterations escalate in higher stage prostate cancers, raising the question whether these epigenetic changes are related.18637271
Prostate Cancer PathwayEpigenetic AlterationsIntriguingly, our data suggest a direct influence of increased EZH2 on altered DNA methylation patterns in prostate cancer.18637271
Communicable DiseasesEpigenetic AlterationsThe high frequency of oncogenic HPV types implicates maternal transmission of HPV and infection of an ectodermal stem cell leading to an epigenetic mosaic and altered skin development manifested along Blaschkos lines.18638629
NeoplasmsEpigenetic AlterationsDNA methylation is a key regulator of gene transcription and genomic stability, and alterations in DNA methylation patterns are frequently detected in human tumors.18639281
Bladder NeoplasmEpigenetic AlterationsPreviously we reported that inactivation of RUNX3 by primarily epigenetic alterations in DNA methylation is closely associated with bladder tumor development, recurrence and progression.18639281
CarcinogenesisEpigenetic AlterationsDNA-methyltransferase-3B (DNMT3B), which plays a role in DNA methylation, is usually aberrant expression involved in carcinogenesis.18662374
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsPolymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methylation in several cancers, thereby modulating the susceptibility to cancer.18662374
Childhood Medulloblastoma, NeoplasmsEpigenetic AlterationsCandidate gene investigations have indicated a significant role for epigenetic events in the pathogenesis of medulloblastoma, the most common malignant brain tumor of childhood.18664619
Carcinoma of lungEpigenetic AlterationsA high-throughput and sensitive method to measure global DNA methylation: application in lung cancer.18673580
Carcinoma of lungEpigenetic AlterationsWe have applied the technology to understand the role of global DNA methylation in the natural history of lung cancer.18673580
Carcinoma of lungEpigenetic AlterationsBy detecting these changes in global DNA methylation, CpGlobal may have a role as a barometer for the onset and development of lung cancer.18673580
Prostate Cancer PathwayEpigenetic AlterationsGenomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer.18676839
Prostate Cancer PathwayEpigenetic AlterationsIn summary, microRNA expression becomes altered with the development and progression of prostate cancer.18676839
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsLastly, we found evidence that some microRNAs are androgen-regulated and that tumor microRNAs influence transcript abundance of protein-coding target genes in the cancerous prostate.18676839
Bladder NeoplasmEpigenetic AlterationsExposure to tobacco smoke is associated with increased DNA methylation at certain genes in both lung and bladder tumors.18676844
Malignant neoplasm of urinary bladderEpigenetic AlterationsWe sought to identify interactions in bladder cancer between DNA methylation and a history of smoking, along with any possible effect of aging.18676844
Carcinoma, Transitional CellEpigenetic AlterationsWe measured DNA methylation in 342 transitional cell carcinoma tumors at BCL2, PTGS2 (COX2), DAPK, CDH1 (ECAD), EDNRB, RASSF1A, RUNX3, TERT, and TIMP3.18676844
CarcinomaEpigenetic AlterationsPotentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma.18677302
Carcinoma, Ovarian Serous AdenocarcinomaEpigenetic AlterationsSpecifically, we show decreased p53 expression and downregulation of miR-195 and miR-497 from the microRNA cluster site at chromosome 17p13.1 in primary peritoneal carcinoma relative to ovarian serous carcinoma.18677302
Malignant NeoplasmsEpigenetic AlterationsRecent work has shown differential expression of mature microRNAs in human cancers.18677302
Carcinoma, Ovarian Serous AdenocarcinomaEpigenetic AlterationsWe characterized the alteration in expression of a select group of microRNAs in primary peritoneal carcinoma relative to matched cases of ovarian serous carcinoma.18677302
Carcinoma, Ovarian Serous Adenocarcinoma, NeoplasmsEpigenetic AlterationsWe provide definitive evidence that there is downregulation of a select group of microRNAs in tumours meeting Gynaecological Oncology Group criteria for primary peritoneal carcinoma relative to ovarian serous carcinoma.18677302
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is known to play an important role in gene transcription and alterations of methylation contribute to the development of certain disorders such as cancer and immunodeficiency.18683034
S-AdenosylhomocysteineEpigenetic AlterationsOur observations suggest that aberrant DNA methylation status reflected by increased plasma SAH concentration and decreased mRNA expression levels of DNMT3A and 3B are possibly involved in the pathogenesis of ITP although the precise mechanisms need further study.18683034
Autoimmune Diseases, Lupus Erythematosus, Systemic, Rheumatoid Arthritis, Right armEpigenetic AlterationsRecent years have found an increasing interest in the role of epigenetic modifications in the etiology of human autoimmune diseases, such as systemic lupus erythromatosus (SLE) and rheumatoid arthritis (RA).18683034
Breast Carcinoma, NeoplasmsEpigenetic AlterationsDNA methylation analysis revealed that the LZTS1 gene was frequently methylated in both cell lines and primary tumors from breast cancer, and the extent of DNA methylation was correlated with reduced expression of the gene.18686028
TRPV6 geneEpigenetic AlterationsThese findings suggested that BMP-6 promoter methylation is likely to be a common epigenetic event at later stages of ATL and that the methylation profiles may be useful for the staging of ATL as well as for evaluation of the individual risk of developing the disease.18688853
Primary malignant neoplasmEpigenetic AlterationsMicro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer.18695884
NeoplasmsEpigenetic AlterationsMany micro-RNAs (miR10a, miR21, miR145, miR212, miR339, miR361) responded to chemoradiotherapy in individual tumor samples, but there was profound intertumoral variability.18695884
Squamous cell carcinoma of esophagusEpigenetic AlterationsThis study was aimed at identifying a recurrence-associated epigenetic prognostic marker in patients with ESCC.18697202
Imprinting (Psychology), AlloisoleucineEpigenetic AlterationsLoss of imprinting (LOI) is an epigenetic alteration involving loss of parental origin-specific expression at normally imprinted genes.18701505
Primary malignant neoplasmEpigenetic AlterationsWe further show that Igf2 LOI occurs with aging in histologically normal human prostate tissues and that this epigenetic alteration was more extensive in men with associated cancer.18701505
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsDNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection.18702824
Breast Cancer CellEpigenetic AlterationsEpigenetic alterations are a hallmark of human cancer.18702824
Malignant neoplasm of urinary bladderEpigenetic AlterationsIndistinct DNA hypermethylation of CDH1 and SFN genes between tumoral and normal urinary bladder samples suggests that these epigenetic features are not suitable biomarkers for urinary bladder cancer.18702824
Breast CarcinomaEpigenetic AlterationsGiven its important role in DNA methylation and synthesis, one-carbon metabolism may affect breast cancer mortality.18708404
Russell-Silver syndromeEpigenetic AlterationsSilver-Russell syndrome (SRS) is characterized by growth failure and dysmorphic features, and is frequently caused by hypomethylation of the paternally derived H19-DMR (epimutation).18709478
Carcinoma, Colorectal CarcinomaEpigenetic AlterationsThese findings suggest that epigenetic changes in the DNA mismatch repair genes play important roles in the development of gastric and colorectal carcinomas and that the SNP of DNA repair genes have little influence on the occurrence of carcinoma in the elderly.18713157
GlioblastomaEpigenetic AlterationsEvaluation of histone acetylation levels showed that histone H3 is more acetylated in glioblastomas than normal brain tissue confirming the downregulation of HDAC mRNA in glioblastomas.18713462
Neurodegenerative DisordersEpigenetic AlterationsTranslational regulation by miRNAs may represent a common mechanism underlying complex neurodegenerative disorders.18723524
Somatic KIT Gene MutationEpigenetic AlterationsClustering of these lesions in the proximal stomach, their close proximity, and the demonstration of different KIT mutations in individual lesions from the same patient point to the existence of distinct subsets of interstitial cells of Cajal with a higher propensity for different somatic KIT exon 11 mutations, possibly as a result of a field effect involving premutational epigenetic alterations or yet unidentified etiologic factors.18724245
Primary malignant neoplasmEpigenetic AlterationsAs DNA methylation has been determined as an important diagnostic biomarker in cancer management, methods for the detection of quantitative DNA methylation which are high-throughput and low-cost are needed.18751375
Colorectal Carcinoma, NeoplasmsEpigenetic AlterationsWith this method, DNA methylation in the promoter of the APC tumour suppressor gene was quantified in a set of colorectal carcinoma samples.18751375
Kidney Cancer pT1a TNM Finding v6 and v7Epigenetic AlterationsPrognostic role of global DNA-methylation and histone acetylation in pT1a clear cell renal carcinoma in partial nephrectomy specimens.18752633
Aggressive behavior, pT1a Stage FindingEpigenetic AlterationsThe percentage of methylation was significantly higher in grades 3 and 4 (P = 0.033), whereas the percentage of histone acetylation was significantly lower (P = 0.023), suggesting therefore that these markers could correlate with tumour aggressiveness in pT1a RCC.18752633
Fuhrman nuclear grade, Aggressive behavior, Renal Cell Carcinoma, Refractory Cytopenia of ChildhoodEpigenetic AlterationsThese epigenetic markers can give us interesting information about chromatin remodelling in RCCs; the percentage of global methylation increases with increasing Fuhrman grade, whereas histone acetylation decreases with increasing grade in small RCC; our results suggest that global hypermethylation and histone hypoacetylation can be assumed to be an early event in RCC and to correlate with tumour aggressiveness.18752633
Carcinogenesis, NeoplasmsEpigenetic AlterationsIn addition to silencing as a result of mutations, loss of heterozygosity, or classic genetic events, epigenetic modification symbolizes essential events during carcinogenesis and tumour development.18752633
Breast CarcinomaEpigenetic AlterationsFour miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer.18755890
Breast CarcinomaEpigenetic AlterationsIn addition, the prognostic value of the candidate miRNAs was determined in ER(-)/LNN breast cancer.18755890
Breast CarcinomaEpigenetic AlterationsIn conclusion, our work connects four miRNAs to breast cancer progression and to several distinct biological processes involved therein.18755890
NeoplasmsEpigenetic AlterationsConcerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells.18756266
NeoplasmsEpigenetic AlterationsDownregulation of these miRNAs allows high levels of Hh-dependent gene expression leading to tumour cell proliferation.18756266
Primary malignant neoplasmEpigenetic AlterationsThese findings identify a novel regulatory circuitry of the Hh signalling and suggest that misregulation of specific miRNAs, leading to its aberrant activation, sustain cancer development.18756266
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAberrant DNA methylation of the transcription factor C/EBPalpha in acute myelogenous leukemia.18757096
Leukemia, Myelocytic, AcuteEpigenetic AlterationsOur results provide further evidence for epigenetic dysregulation of C/EBPalpha in AML.18757096
Autoimmune Diseases, Primary malignant neoplasmEpigenetic AlterationsIt is known that aberrant microRNA expression can play important roles in cancer, but the role of microRNAs in autoimmune diseases is only beginning to emerge.18759964
Rheumatoid ArthritisEpigenetic AlterationsOur data thus demonstrate that microRNA expression in rheumatoid arthritis peripheral blood mononuclear cells mimics that of synovial tissue/fibroblasts.18759964
Chronic Lymphocytic LeukemiaEpigenetic AlterationsEpigenetic dysregulation of the Wnt signalling pathway in chronic lymphocytic leukaemia.18765431
Colonic NeoplasmsEpigenetic AlterationsOncogenetic tree model of somatic mutations and DNA methylation in colon tumors.18767147
Glioblastoma, Primary malignant neoplasmEpigenetic AlterationsHere we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas--the most common type of adult brain cancer--and nucleotide sequence aberrations in 91 of the 206 glioblastomas.18772890
Mismatch Repair Deficiency, GlioblastomaEpigenetic AlterationsFurthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications.18772890
S100A4 protein, human, Primary malignant neoplasmEpigenetic AlterationsHuman cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation.18772890
NeoplasmsEpigenetic AlterationsAberrant DNA methylation of 5-CpG islands located within gene promoters has been identified as a mechanism for transcriptional inactivation of tumor suppressor genes.18773859
CholangiocarcinomaEpigenetic AlterationsTaken together, these results suggest that aberrant DNA methylation may contribute to the tumorigenesis of cholangiocarcinoma.18773859
SF3B1 wt Allele, Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe pattern of results suggests that MDS was associated with the DNA methylation status and the risk for AML was associated with both the DNA synthesis and DNA methylation status.18774170
Thymic Carcinoma, ThymomaEpigenetic AlterationsWe examined aberrant DNA methylation of DAP-K, p-16, MGMT and HPP1 genes in 26 thymomas and 6 thymic carcinoma to clarify the association between aberrant DNA methylation and clinicopathological features.18778870
Behavior, THM gene, Thymic Carcinoma, NeoplasmsEpigenetic AlterationsAberrant DNA methylation was more frequent in thymic carcinoma than in thymoma, and the frequency of DNA methylation in thymic epithelial tumours is roughly parallel to their malignant behaviour.18778870
Carcinogenesis, Carcinoma, EndometrioidEpigenetic AlterationsTo identify a DNA methylation signature of endometrioid carcinoma of the endometrium (EEC) in the early stages of endometrial carcinogenesis.18783461
Neoplastic diseaseEpigenetic AlterationsDNA methylation is a common molecular alteration in human neoplasia and can be detected easily in the bloodstream of patients.18784433
Breast CarcinomaEpigenetic AlterationsEpigenetic markers in sera, especially BRCA1/p16, may be more promising targets for the diagnosis of sporadic breast cancer than previous prognostic markers.18784433
CarcinogenesisEpigenetic AlterationsThe epigenetic pathway of colorectal carcinogenesis has recently become the focus of attention.18795670
NeoplasmsEpigenetic AlterationsThe most common epigenetic change is the promoter hypermethylation of tumor suppressor genes.18795670
Squamous cell carcinoma of esophagusEpigenetic AlterationsIdentification of an invasion and tumor-suppressing gene, Endoglin (ENG), silenced by both epigenetic inactivation and allelic loss in esophageal squamous cell carcinoma.18798555
NeoplasmsEpigenetic AlterationsBoth epigenetic methylation and allelic loss appear to contribute to ENG downregulation in tumor cells.18798555
CarcinogenesisEpigenetic AlterationsAberrant DNA methylation plays important roles during multistage carcinogenesis in various human organs.18799028
Gastric AdenocarcinomaEpigenetic AlterationsOur data suggest that methylation of transmembrane protein containing epidermal growth factor and folistatin domains/hyperplastic polyposis 1 is present in the majority of gastric adenocarcinomas and in the surrounding tumoural-free area, indicating that this epigenetic change may point to a field effect in the gastric mucosa.18799374
Liver carcinomaEpigenetic AlterationsEpigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter.18801366
Metastasis, NeoplasmsEpigenetic AlterationsIn addition to genetic alterations, epigenetic changes underlie tumor progression and metastasis.18801366
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsPromoter methylation can silence tumor suppressor genes, and reactive oxygen species (ROS) promote DNA damage, although the relationship between ROS and epigenetic changes in cancer cells is not clear.18801366
CarcinogenesisEpigenetic AlterationsThese findings provide novel mechanistic insights into epigenetic modulations induced by ROS in the process of carcinogenesis.18801366
Prostate Cancer PathwayEpigenetic AlterationsPCA3 is a prostate specific, nonprotein coding RNA that is over expressed in prostate cancer.18801539
NeoplasmsEpigenetic AlterationsSince then, the concentration of free circulating plasma DNA has been studied as well as the genetic alterations and epigenetic alterations of tumour DNA of patients that suffer from various types of tumours.18804892
Breast Carcinoma, MetastasisEpigenetic AlterationsMicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis.18812439
miR-181b, human, MIR30A wt Allele, MIRLET7F1 wt AlleleEpigenetic AlterationsNine miRNAs of hsa-miR-21, hsa-miR-365, hsa-miR-181b, hsa-let-7f, hsa-miR-155, hsa-miR-29b, hsa-miR-181d, hsa-miR-98, and hsa-miR-29c were observed to be up-regulated greater than twofold in BC compared with NAT, whereas seven miRNAs of hsa-miR-497, hsa-miR-31, hsa-miR-355, hsa-miR-320, rno-mir-140, hsa-miR-127 and hsa-miR-30a-3p were observed to be down-regulated greater than twofold.18812439
NeoplasmsEpigenetic AlterationsThe most significantly up-regulated miRNAs, hsa-mir-21 (miR-21), was quantitatively analyzed by TaqMan real-time PCR in 113 BC tumors.18812439
Breast Carcinoma, Metastasis, Neoplasms, Best Case Imputation TechniqueEpigenetic AlterationsThis study could identify the differentiated miRNAs expression profile in BC and reveal that miR-21 overexpression was correlated with specific breast cancer biopathologic features, such as advanced tumor stage, lymph node metastasis, and poor survival of the patients, indicating that miR-21 may serve as a molecular prognostic marker for BC and disease progression.18812439
Malignant NeoplasmsEpigenetic AlterationsTo our knowledge, the present study is the first to demonstrate the epigenetic inactivation of TU3A in human cancers.18813805
NeoplasmsEpigenetic AlterationsOur data showed that 10/49 (20.4%), 6/48 (12.5%) and 14/49 (28.6%) of tumors were methylated with a DNA methylation level >0.2 in CDKN2A, DPYD and MLH1, respectively.18813836
NeoplasmsEpigenetic AlterationsThe tumor DNA samples had unique DNA methylation patterns, which were high-degree and multiple-site methylation, but the normal DNA samples had no or a low-degree and dispersed single-site methylation.18813836
NeoplasmsEpigenetic AlterationsIn addition, an inverse correlation in those methylated tumors was observed between DNA methylation and RNA expression for MLH1 (RS=-0.62, P=0.003), but not for CDKN2A and DPYD.18813836
Pancreatic Intraductal Papillary Mucinous Neoplasm, Intraductal papillary mucinous neoplasm, Non-Neoplastic Pancreatic DisorderEpigenetic AlterationsIdentifying the alterations in DNA methylation that arise during intraductal papillary mucinous neoplasm development may facilitate the development of markers that could be used to differentiate intraductal papillary mucinous neoplasms from non-neoplastic pancreatic cystic lesions.18820670
Intraductal papillary mucinous neoplasmEpigenetic AlterationsThus, aberrant DNA methylation increases with histologic grades of intraductal papillary mucinous neoplasm.18820670
CarcinogenesisEpigenetic AlterationsOur study provides evidence that epigenetic inactivation of EphA7 may be involved in prostate carcinogenesis.18821581
Carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsAs demethylating agents are now entering lung cancer trials, it is imperative to gain a greater insight into the potential reactivation of silent retrotransposons in order to advance for the clinical utilization of epigenetics in cancer therapy.18823011
Benign neoplasm of bladder, NeoplasmsEpigenetic AlterationsPromoter hypermethylation in a panel of tumour suppressor genes involved in cell cycle control, apoptosis and DNA repair was analyzed in superficial bladder tumours in order to evaluate the suitability of epigenetic biomarkers for an earlier prediction of the aggressive course of the disease.18824877
Breast Carcinoma, CarcinogenesisEpigenetic AlterationsSince other Wnt signalling inhibitors have been reported to be targets of epigenetic inactivation in human breast cancer, we questioned if DKK3 expression is also epigenetically silenced during breast carcinogenesis and therefore might contribute to oncogenic Wnt signalling commonly found in this disease.18826564
Malignant tumor of colonEpigenetic AlterationsUtilising 649 colon cancers (stage I-IV) in two independent cohort studies, we quantified DNA methylation in eight CIMP-specific promoters (CACNA1G, CDKN2A (p16), CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1) as well as CHFR, HIC1, IGFBP3, MGMT, MINT1, MINT31, p14, and WRN by using MethyLight technology.18832519
KeloidEpigenetic AlterationsPAI-1-targeted interventions, such as small interfering RNA and lentiviral short hairpin RNA-containing microRNA sequence suppression reported here, may have therapeutic utility in the prevention of keloid scarring.18832570
SF3B1 wt Allele, Leukemia, Myelocytic, AcuteEpigenetic AlterationsAberrant DNA methylation is a dominant mechanism in MDS progression to AML.18832655
SF3B1 wt Allele, Leukemia, Myelocytic, AcuteEpigenetic AlterationsIn 184 patients with MDS and AML, DNA methylation microarray and high-density single nucleotide polymorphism array (SNP-A) karyotyping were used to assess the relative contributions of aberrant DNA methylation and chromosomal deletions to tumor-suppressor gene (TSG) silencing during disease progression.18832655
Leukemia, Myelocytic, AcuteEpigenetic AlterationsHowever, the ubiquity, extent, and correlation with disease progression suggest that aberrant DNA methylation is the dominant mechanism for TSG silencing and clonal variation in MDS evolution to AML.18832655
Chronic inflammatory disorder, Ulcerative ColitisEpigenetic AlterationsThese findings expand the known roles of miRNAs, indicating that tissues from patients with UC, and possibly other chronic inflammatory diseases, have altered miRNA expression patterns.18835392
Ulcerative ColitisEpigenetic AlterationsMicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha.18835392
Ulcerative ColitisEpigenetic AlterationsActive UC was associated with the differential expression of 11 miRNAs; 3 were significantly decreased and 8 were significantly increased in UC tissues.18835392
Breast CarcinomaEpigenetic AlterationsTo what extent epigenetic alterations of the APC gene may differ according to specific breast cancer phenotypes, remains to be elucidated.18841156
Hematologic Neoplasms, Malignant neoplasm of liver, NeoplasmsEpigenetic AlterationsDLC1 (deleted in liver cancer 1), a tumor suppressor gene that encodes a RhoGTPase-activating protein, is recurrently downregulated or silenced in various solid tumors and hematological malignancies because of epigenetic modifications or genomic deletion.18923442
Multiple MyelomaEpigenetic AlterationsGiven the myeloma cells sensitivity to the reactivation of DLC1 function, the potential for molecular targeted therapy of DLC1-mediated pathways as well as epigenetic therapies hold prospects.18923442
Renal Cell Carcinoma PathwayEpigenetic AlterationsGenome-wide microRNA expression profiling in renal cell carcinoma: significant down-regulation of miR-141 and miR-200c.18925646
Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA-21 (miR-21) is considered an onco-microRNA given its abilities to suppress the actions of several tumor suppressor genes and to promote tumor cell growth, invasion and metastasis.18932017
NeoplasmsEpigenetic AlterationsThe expression of miR-21 in tumor samples was measured with a TaqMan microRNA assay using U6 as reference.18932017
Breast CarcinomaEpigenetic AlterationsThe study supports the notion that miR-21 is an onco-microRNA for breast cancer.18932017
Primary malignant neoplasmEpigenetic AlterationsHere, the prognostic significance of this epigenetic marker with respect to severe 5-FU toxicity was assessed in 27 cancer patients receiving 5-FU based chemotherapy, including 17 patients experiencing severe toxic side effects following drug administration, none of which were carriers of a known deleterious DPYD mutation, and ten control patients.18937829
Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic events in normal colonic mucosa surrounding colorectal cancer lesions.18938072
Clinical CoordinatorEpigenetic AlterationsHowever, current data do not prove direct involvement of this epigenetic modification in the early stages of CRC.18938072
Carcinogenesis, Colorectal NeoplasmsEpigenetic AlterationsOur results indicate that epigenetic changes in mucosa surrounding colorectal neoplastic lesions may describe a field cancerisation phenomenon that may occur previous to genetic alterations in early stages of carcinogenesis.18938072
Primary malignant neoplasmEpigenetic AlterationsA possible epigenetic regulation of the two isoenzymes of fructose 1,6-bisphosphatase (FBPase) was studied in liver, muscle, mamma, breast cancer and in different cancer cell lines.18938139
Degenerative polyarthritisEpigenetic AlterationsDNA methylation was lost at specific CpG sites in the ADAMTS-4 promoter in OA chondrocytes, suggesting that the increased gene expression was more than a simple up-regulation, but involved loss of DNA methylation at specific CpG sites, resulting in a heritable and permanent expression of ADAMTS-4 in OA chondrocytes.18941754
melanomaEpigenetic AlterationsFurthermore, treatment of C8161 and MeWo cells with 5-azacytidine, a DNA demethylating agent, induced the expression of PAX4, suggesting that DNA methylation repressed the PAX4 gene expression in human melanoma.18949370
Malignant NeoplasmsEpigenetic AlterationsEpigenetic inactivation of SFRP1 by methylation of its promoter CpG island has recently been reported in several types of cancers.18949430
Squamous cell carcinomaEpigenetic AlterationsPrognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus.18953329
Primary malignant neoplasmEpigenetic AlterationsPatterns of global histone modifications have been recently suggested as outcome predictors in cancer patients.18953329
Squamous cell carcinoma of esophagusEpigenetic AlterationsTo date, there has been no report on the prognostic significance of global histone modifications in esophageal squamous cell carcinoma.18953329
Primary malignant neoplasmEpigenetic AlterationsThe RNA from 9 cancer specimens was compared to 4 normal specimens with real-time PCR using the TaqMan Array Human MicroRNA panel.18954897
ovarian neoplasmEpigenetic AlterationsThe detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform.18954897
ovarian neoplasmEpigenetic AlterationsTo determine the utility of serum miRNAs as biomarkers for epithelial ovarian cancer.18954897
Primary malignant neoplasmEpigenetic AlterationsReal-time PCR for the 21 individual miRNAs was performed on the remaining 19 cancer specimens and 11 normal specimens.18954897
Primary malignant neoplasmEpigenetic AlterationsEight miRNAs of the original twenty-one were identified that were significantly differentially expressed between cancer and normal specimens using the comparative C(t) method.18954897
Primary malignant neoplasmEpigenetic AlterationsMiRNAs-21, 92, 93, 126 and 29a were significantly over-expressed in the serum from cancer patients compared to controls (p<.01).18954897
ovarian neoplasmEpigenetic AlterationsWe demonstrate that the extraction of RNA and subsequent identification of miRNAs from the serum of individuals diagnosed with ovarian cancer is feasible.18954897
Degenerative polyarthritisEpigenetic Alterationsp21(WAF1/CIP1) was previously suggested to be down-regulated in OA chondrocytes and is known to be regulated by epigenetic modulation.18954998
Admitting diagnosisEpigenetic AlterationsFurthermore, up-regulation of AZGP1 mRNA in AD may be affected by chromatin remodeling by means of histone acetylation.18978557
NeoplasmsEpigenetic AlterationsTo determine whether AZGP1 expression in this subset of tumors might be affected by epigenetic mechanisms, low AZGP1-expressing A549 and SKLU1 AD cell lines were treated with TSA and 5-AZA.18978557
Breast CarcinomaEpigenetic AlterationsThese data indicate that EGFR as well as HER2 are prognostic factors of worse clinical outcomes, whereas HER3 and HER4 gene transcription is associated with better prognosis in high-risk early breast cancer.18985033
Degenerative polyarthritisEpigenetic AlterationsBoth primary and secondary OA were characterized by loss of aggrecan, formation of clones, and abnormal expression of the proteases that correlated with epigenetic DNA demethylation.18985702
Breast CarcinomaEpigenetic AlterationsAlthough clinical patient outcome was not associated with SFRP2 methylation, the high frequency of this epimutation and its putative specificity to neoplastic cells may qualify SFRP2 promoter methylation as a potential candidate screening marker helping to improve early breast cancer detection.18990230
Breast CarcinomaEpigenetic AlterationsPromoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer.18990230
Breast CarcinomaEpigenetic AlterationsThe SFRP2 gene is a high-frequent target of epigenetic inactivation in human breast cancer.18990230
Colonic NeoplasmsEpigenetic AlterationsColon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.18992263
Tetranitromethane, Metastasis, Liver carcinomaEpigenetic AlterationsThe low-expression or non-expression of NGX6 gene plays an important role in the gene transcription level in hepatocellular carcinoma.The expression of NGX6 gene is related with TNM staging and lymph node metastasis in hepatocellular carcinoma.19001737
Colorectal CarcinomaEpigenetic AlterationsMETHOLODOLOGY/PRINCIPAL FINDINGS: DNA methylation at 16 CpG islands [the above 5 plus CDKN2A (p16), CHFR, CRABP1, HIC1, IGFBP3, MGMT, MINT1, MINT31, MLH1, p14 (CDKN2A/ARF) and WRN] was quantified in 904 colorectal cancers by real-time PCR (MethyLight).19002263
Degenerative polyarthritisEpigenetic AlterationsWe have identified a number of differentially expressed miRNAs in late-stage human OA cartilage and bone.19008124
Hollings Cancer CenterEpigenetic AlterationsOur results show that epigenetic silencing of Tip30 gene expression by CpG island DNA hypermethylation is associated with poor prognosis in patients with HCC.19010857
Degenerative polyarthritisEpigenetic AlterationsMicroRNA profiling of patient-derived osteoarthritic cartilage in comparison to normal cartilage, revealed a 16 microRNA osteoarthritis gene signature.19011694
Colorectal Cancer PathwayEpigenetic AlterationsSensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay.19018278
Clinical CoordinatorEpigenetic AlterationsAnalysis of SEPT9 DNA methylation in plasma represents a straightforward, minimally invasive method to detect all stages of CRC with potential to satisfy unmet needs for increased compliance in the screening population.19018278
Myeloid Leukemia, ChronicEpigenetic AlterationsThe epigenetic changes of TSGs are now recognized as a mechanism contributing to the development of chronic myeloid leukemia (CML).19018866
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsAdequate intake of folate, methionine, riboflavin, and vitamin B-6 may prevent aberrant DNA methylation and thereby protect against colorectal cancer (CRC).19022960
Malignant tumor of colonEpigenetic AlterationsUsing 643 colon cancers in two independent prospective cohorts, we quantified DNA methylation in repetitive long interspersed nucleotide element-1 (LINE-1) elements using pyrosequencing, which is a good indicator of global DNA methylation level.19033568
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsGenome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome.19037089
CarcinogenesisEpigenetic AlterationsTo clarify genome-wide DNA methylation profiles during multistage renal carcinogenesis, bacterial artificial chromosome array-based methylated CpG island amplification (BAMCA) was performed.19037089
Cell of ClaudiusEpigenetic AlterationsIn individual patients, DNA methylation status in N was basically inherited by the corresponding clear cell RCC.19037089
Hollings Cancer CenterEpigenetic AlterationsThese results, thus, suggest that JNK1 plays important roles in the development of human HCC partially through the epigenetic mechanisms.19041150
Malignant Head and Neck NeoplasmEpigenetic AlterationsEpigenetic inactivation of galanin receptor 1 in head and neck cancer.19047085
Squamous cell carcinoma of vulvaEpigenetic AlterationsThese findings underscore the contribution of both genetic and epigenetic events to the underlying pathogenesis of squamous cell carcinoma of the vulva.19047905
Primary malignant neoplasmEpigenetic AlterationsAltered DNA methylation in cancer cells is characterized by focal CpG island hypermethylation and diffuse genomic hypomethylation.19048291
Barrett Esophagus, Helicobacter pylori, Communicable DiseasesEpigenetic AlterationsGenetic or epigenetic alterations in Barretts esophagus (BE) with/without Helicobacter pylori (H. pylori) infection remain unclear.19048617
Breast CarcinomaEpigenetic AlterationsNovel genetic variants in microRNA genes and familial breast cancer.19048628
Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA) plays an important role in tumorigenesis, but whether miRNA is a cancer predisposition factor or not is still unknown.19048628
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsConsidering the fact that miRNA regulates a number of tumor suppressor genes (TSGs) and oncogenes, genetic variations in miRNA genes could affect the levels of expression of TSGs or oncogenes and, thereby, cancer risk.19048628
Breast CarcinomaEpigenetic AlterationsTo test this hypothesis, we screened genetic variants in 17 selected miRNA genes, which are predicted to regulate key breast cancer genes, in 42 patients with familial breast cancer.19048628
Breast CarcinomaEpigenetic AlterationsOur findings suggest that functional genetic variants in miRNA genes can potentially alter the regulation of key breast cancer genes.19048628
SclerodermaEpigenetic AlterationsAdditionally, these data also imply that epigenetic factors, such as Dnmt1, may be involved in the maintenance of the scleroderma phenotype.19054252
precancerous lesionsEpigenetic AlterationsEpigenetic changes of this type play undisputed roles in cell transformation when they involve genes that safeguard genome stability, and they can also be detected in precancerous lesions and seemingly normal peritumoral tissues.19060925
Colorectal Carcinoma, Colorectal Cancer PathwayEpigenetic AlterationsThese findings paralleled immunohistochemical patterns of hMLH1 and MGMT protein loss in an independent series of 231 colorectal cancers and were consistent with current epigenetic profiles of colorectal cancer subsets.19060925
Malignant NeoplasmsEpigenetic AlterationsThey suggest the intriguing possibility that the epigenetic signatures of cancers may have early-stage, normal-tissue counterparts that reflect potentially important aspects of the initial carcinogenetic process.19060925
Adenocarcinoma of pancreasEpigenetic AlterationsThe prevalence of mutant KRAS2, inactivation of TP53 and SMAD4, and aberrant DNA methylation of a seven-gene panel is similar in familial pancreatic adenocarcinomas as in sporadic pancreatic adenocarcinomas.19064568
Pancreatic carcinoma, familialEpigenetic AlterationsGenetic and epigenetic alterations of familial pancreatic cancers.19064568
Malignant neoplasm of pancreasEpigenetic AlterationsLittle is known about the genetic and epigenetic changes that contribute to familial pancreatic cancers.19064568
Endometrial Endometrioid AdenocarcinomaEpigenetic AlterationsDysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women.19065659
Myometrial InvasionEpigenetic AlterationsThe expression of a sub-group of miRNAs was significantly correlated with clinico-pathological characteristics including stage, myometrial invasion, recurrence and lymph node involvement.19065659
Waldenstrom MacroglobulinemiaEpigenetic AlterationsmicroRNA expression in the biology, prognosis, and therapy of Waldenstrom macroglobulinemia.19074725
Malignant Neoplasms, Tumor Suppressor Genes, NeoplasmsEpigenetic AlterationsIt is also known that miRNAs play a role in human cancers where they can act either as oncogenes, down-regulating tumor suppressor genes, or as onco-suppressors, targeting molecules critically involved in promotion of tumor growth.19074879
ovarian neoplasmEpigenetic AlterationsMicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer.19074899
Late stageEpigenetic AlterationsFinally, using miRNA microarray, we found that decreased let-7i expression was significantly associated with the shorter progression-free survival of patients with late-stage ovarian cancer (n = 72, P = 0.042).19074899
ovarian neoplasmEpigenetic AlterationsOur recent studies showed that miRNAs exhibit genomic alterations at a high frequency and their expression is remarkably deregulated in ovarian cancer, strongly suggesting that miRNAs are involved in the initiation and progression of this disease.19074899
Heart failureEpigenetic AlterationsGenome-wide histone methylation profile for heart failure.19077033
Heart failure, Cardiac HypertrophyEpigenetic AlterationsEpigenetic alterations are implicated in the development of cardiac hypertrophy and heart failure, but little is known of which epigenetic changes in which regions of the genome play such a role.19077033
Heart failureEpigenetic AlterationsOur data collectively reveal global epigenetic changes in cardiac myocytes associated with heart failure.19077033
Primary malignant neoplasmEpigenetic AlterationsEpigenetic regulation of the TFPI-2 gene, through methylation of CpG islands, has been advocated in cancer.19081094
CarcinogenesisEpigenetic AlterationsDNA methylation is one of the major events in the early process of gastric carcinogenesis and it also occurs in non-neoplastic gastric mucosa.19082889
Infection caused by Helicobacter pyloriEpigenetic AlterationsOur data suggest that MTHFR 677T carrier influences the risk of DNA methylation in gastric mucosa in the long-term outcome of the H. pylori infection.19082889
Stomach CarcinomaEpigenetic AlterationsWe analyzed its epigenetic inactivation, biological effects, and prognostic significance in gastric cancer.19084528
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe epigenetic silencing of PMF1 by hypermethylation was tested in bladder cancer cells (n = 11) after azacytidine treatment.19088041
NeoplasmsEpigenetic AlterationsGene expression in tumours is regulated by environmental as well as genetic/epigenetic factors.19102008
NeoplasmsEpigenetic AlterationsMiR-221 and miR-222 are two highly homologous microRNAs whose upregulation has been recently described in several types of human tumors, for some of which their oncogenic role was explained by the discovery of their target p27, a key cell cycle regulator.19107213
Acute lymphocytic leukemiaEpigenetic AlterationsResidual DNA methylation at remission is prognostic in adult Philadelphia chromosome-negative acute lymphocytic leukemia.19109226
Acute lymphocytic leukemiaEpigenetic AlterationsPretreatment aberrant DNA methylation patterns are stable at time of relapse in acute lymphocytic leukemia (ALL).19109226
Acute lymphocytic leukemiaEpigenetic AlterationsIn conclusion, detection of epigenetic alterations allows the identification of patients with ALL with standard risk but with poor prognosis.19109226
Breast CarcinomaEpigenetic AlterationsIn summary, the presented data demonstrate for the first time the reduced EFEMP1 expression on RNA and protein level in a substantial number of sporadic breast carcinomas and its correlation with epigenetic alterations.19115204
Colorectal NeoplasmsEpigenetic AlterationsMultiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact.19117505
Alzheimers DiseaseEpigenetic AlterationsEpigenetic changes in Alzheimers disease: decrements in DNA methylation.19117641
Admitting diagnosisEpigenetic AlterationsWe show, for the first time, neuronal immunoreactivity for all 10 of the epigenetic markers and factors, with highly significant decrements in AD cases.19117641
Malignant Pleural MesotheliomaEpigenetic AlterationsEpigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome.19118007
Malignant Pleural MesotheliomaEpigenetic AlterationsWe have added to the growing body of evidence that cellular epigenetic dysregulation is a critical mode of action for asbestos in the induction of pleural mesothelioma.19118007
Malignant NeoplasmsEpigenetic AlterationsImportantly, these findings hold great promise for using epigenetic profiling in the diagnosis and prognosis of human cancers.19118007
Carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsQuantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors.19118009
Carcinoma of lung, NeoplasmsEpigenetic AlterationsTogether, this study identifies aberrant DNA methylation patterns in lung cancer and thus exemplifies the mechanism by which environmental factors may interact with key genes involved in tumor suppression and contribute to lung cancer.19118009
Huntington DiseaseEpigenetic AlterationsThe bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntingtons disease.19118166
Pathology, NeoplasmsEpigenetic AlterationsPhosphatase and tension homolog deleted on chromosome 10 (PTEN), a tumor suppressor, is frequently deficient in various pathologies due to mutation or epigenetic alterations.19118244
NeoplasmsEpigenetic AlterationsPTEN promoter hypermethylation is a major epigenetic silencing mechanism leading to activation of angiogenesis in tumors.19118244
Cerebrocostomandibular SyndromeEpigenetic AlterationsWe reported here for the first time the involvement of PTEN promoter methylation in CCMs, particularly in familial CCMs, suggesting this epigenetic alteration as a potential pathomechanism of CCMs.19118244
Myeloid Leukemia, ChronicEpigenetic AlterationsTo investigate whether epigenetic silencing of sFRP is responsible for the observed Wnt activation in CML, we studied the methylation and mutational status of the sFRP1 promoter in 48 chronic phase CML patients.19118898
CarcinogenesisEpigenetic AlterationsOur findings add to increasing evidence that DNA methylation plays an important role even at an early stage of colorectal carcinogenesis.19124508
CarcinogenesisEpigenetic AlterationsTherefore, it could be suggested that hypermethylation of p16(INK4A) promoter is one of the epigenetic factors affecting the progress of sporadic breast carcinogenesis in Iranian patients.19125298
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsEpigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma.19126652
NeoplasmsEpigenetic AlterationsAmong tumors, there were significant associations between specific DNA methylation profile classes and tobacco smoking and alcohol exposures.19126652
Squamous cell carcinoma of the head and neck, NeoplasmsEpigenetic AlterationsWe found that the etiologic heterogeneity of HNSCC is reflected in specific patterns of molecular epigenetic alterations within the tumors and that the DNA methylation profiles may hold clinical promise worthy of further study.19126652
Squamous cell carcinoma of the head and neckEpigenetic AlterationsPrevious research has identified individual epigenetic alterations and, in some cases, the relationship of these alterations with carcinogen exposure or patient outcomes, suggesting that specific exposures give rise to specific types of molecular alterations in HNSCCs.19126652
NeoplasmsEpigenetic AlterationsThe overall pattern of epigenetic alteration could significantly distinguish tumor from normal head and neck epithelial tissues (P < 0.0001) more effectively than specific gene methylation events.19126652
Clinical Coordinator, NeoplasmsEpigenetic AlterationsThe authors of this report hypothesized that environmental factors and lifestyle differences among various ethnic groups may differentially influence the epigenetic regulation of tumor suppressor genes in CRC.19127559
Primary malignant neoplasmEpigenetic AlterationsGenetic aberrations such as allelic imbalance (AI) and epigenetic changes such as promoter hypermethylation have been detected in circulating DNA of cancer patients.19131636
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsWe hypothesized that circulating multimarker DNA assays detecting both genetic and epigenetic markers in serum would be useful in assessing PCa patients.19131636
Osteosarcoma, Liver carcinomaEpigenetic AlterationsMicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma.19133651
Hollings Cancer CenterEpigenetic AlterationsThe results showed that among the 20 HCC samples analyzed, microRNA-101 was significantly down-regulated twofold or more (twofold to 20-fold) in 16 samples compared with the matching nontumoral liver tissues.19133651
Hollings Cancer CenterEpigenetic AlterationsIn in vitro Matrigel invasion and Transwell migration assays, enhanced microRNA-101 expression inhibited the invasion and migration of cultured HCC cells, respectively.19133651
Hollings Cancer CenterEpigenetic AlterationsThese findings suggest that microRNA-101 may play an important role in HCC.19133651
Hollings Cancer CenterEpigenetic AlterationsMicroRNA-101, which is aberrantly expressed in HCC, could repress the expression of the FOS oncogene.19133651
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsAlthough there is emerging evidence that some microRNAs can function as oncogenes or tumor suppressors, the specific role of miRNA in human hepatocellular carcinoma (HCC) is unclear at this point.19133651
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNA) can act as oncogenes or tumor suppressors and modulate the expression of approximately one third of all human genes.19138993
Combined Lung Small Cell Carcinoma and Lung Adenocarcinoma, Bronchioloalveolar AdenocarcinomaEpigenetic AlterationsDNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components.19144441
AdenocarcinomaEpigenetic AlterationsOur results indicate the involvement of epigenetic alterations in the progression of adenocarcinoma with BAC components.19144441
Chronic Lymphocytic LeukemiaEpigenetic AlterationsmicroRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification.19144983
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAberrant expression of microRNAs has been recently associated with chronic lymphocytic leukemia (CLL) outcome.19144983
Stomach CarcinomaEpigenetic AlterationsmicroRNA expression profile in undifferentiated gastric cancer.19148490
Stomach CarcinomaEpigenetic AlterationsThe expression levels of 3 miRNAs (mir-34b, mir-34c and mir-128a) were significantly upregulated and those of 3 miRNAs (mir-128b, mir-129 and mir-148) were downregulated in undifferentiated gastric cancer tissue when compared with those of the paired normal tissues.19148490
Stomach CarcinomaEpigenetic AlterationsOur investigation provides a list of candidate miRNAs that may be associated with the prognosis in undifferentiated gastric cancer patients.19148490
Primary malignant neoplasmEpigenetic AlterationsConsequently, promoter hypermethylation, being the most important aberrant epigenetic characteristic, has been intensively investigated for its biomarker potential in this cancer type.19148529
NeoplasmsEpigenetic AlterationsTumor biopsies revealed the epigenetic silencing of MGMT in 42.5% (17 of 40) of patients and of TIMP3 in 40.5% (17 of 42) of cases.19148529
Squamous cell carcinoma of the head and neckEpigenetic AlterationsIn conclusion, in this representative group of 46 patients with advanced HNSCC treated by radiotherapy only, the epigenetic silencing of TIMP3 and CDH1 predicted a better outcome.19148529
Breast CarcinomaEpigenetic AlterationsThis research demonstrates the potential for gene-body epigenetic misregulation of ATM and other cancer-related genes in peripheral blood DNA that may be useful as a novel marker to estimate breast cancer risk.19153073
Bladder NeoplasmEpigenetic AlterationsOur data suggest that epigenetic alterations may have an important role in the mechanism of bladder tumor recurrence.19157440
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsMicroRNA-143 as a tumor suppressor for bladder cancer.19157460
Malignant neoplasm of urinary bladder, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsmiRNA profiling of human bladder cancer and matched normal urothelial epithelium controls revealed that 37 miRNAs were up-regulated and 38 were down-regulated in cancer tissues, of which the expression of miRNA-143 was 13.7 times lower in tumor than in the matched control.19157460
Transitional cell carcinoma of bladder, NeoplasmsEpigenetic AlterationsmiRNA-143 may function as a tumor suppressor in bladder transitional cell carcinoma.19157460
Malignant neoplasm of urinary bladderEpigenetic AlterationsmiRNAs are differentially expressed in bladder cancer tissues.19157460
Glioblastoma Multiforme PathwayEpigenetic AlterationsmiR-21 and 221 were overexpressed in glioma samples, whereas miRNA 181b was downregulated compared with normal brain tissue.19159078
Glioma, NeoplasmsEpigenetic AlterationsmiRNA-21 was hyperexpressed in all tumor samples whereas higher levels of miRNA-221 were found in high-grade gliomas.19159078
NeoplasmsEpigenetic AlterationsRecent evidence indicates that miRNAs can function both as tumor suppressors and as oncogenes.19159078
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsThe different expression pattern observed in tumors at different stages of malignancy is probably dependent on the cell-specific repertoire of target genes of tumors sharing different molecular pathways activity and suggests miRNAs may have also a place in diagnosis and staging of brain tumors.19159078
Acute lymphocytic leukemiaEpigenetic AlterationsComplete consistency in the correlation between both histone marks, the presence of DNA methylation around these miRNAs, and their expression patterns was confirmed in the six ALL cell lines.19164206
Acute lymphocytic leukemiaEpigenetic AlterationsMethylation status (methylation-specific polymerase chain reaction [PCR]) and expression (quantitative PCR) of miRNAs showing a pattern of histone modifications linked to a closed chromatin structure were analyzed in a panel of six ALL cell lines and in 353 ALL patients.19164206
Acute lymphocytic leukemiaEpigenetic AlterationsEpigenetic regulation of microRNAs in acute lymphoblastic leukemia.19164206
Acute lymphocytic leukemiaEpigenetic AlterationsA total of 65% of the ALL samples had at least one miRNA methylated (methylated group).19164206
Acute lymphocytic leukemiaEpigenetic AlterationsAberrant miRNA methylation is a common phenomenon in ALL that affects the clinical outcome of these patients.19164206
Acute lymphocytic leukemiaEpigenetic AlterationsTo identify microRNAs (miRNAs) epigenetically regulated in acute lymphoblastic leukemia (ALL).19164206
MEN1 wt AlleleEpigenetic AlterationsTo identify alterations underlying this defect, we searched for disruption and epigenetic silencing of the MEN1 gene.19170121
Stomach CarcinomaEpigenetic AlterationsDNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients.19170207
Primary malignant neoplasmEpigenetic AlterationsHowever, the relationship between DNA methylation and the past lifestyle in cancer patients remains largely unknown.19170207
Hepatitis B, Hepatitis C, Liver carcinomaEpigenetic AlterationsDifferential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma.19173277
Communicable Diseases, Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA) plays an important role in the pathology of various diseases, including infection and cancer.19173277
Hepatitis C, Hepatobiliary DisorderEpigenetic AlterationsDetailed analysis of the differentially expressed miRNA revealed two types of miRNA, one associated with HBV and HCV infections (n = 19), the other with the stage of liver disease (n = 31).19173277
Hollings Cancer CenterEpigenetic AlterationsOut of the 31 miRNAs associated with disease state, 17 were down-regulated in HCC, which up-regulated cancer-associated pathways such as cell cycle, adhesion, proteolysis, transcription, and translation; 6 miRNAs were up-regulated in HCC, which down-regulated anti-tumor immune response.19173277
Hepatitis C, Hepatobiliary DisorderEpigenetic AlterationsmiRNAs are important mediators of HBV and HCV infection as well as liver disease progression, and therefore could be potential therapeutic target molecules.19173277
Lynch SyndromeEpigenetic AlterationsLarge genomic rearrangements and germline epimutations in Lynch syndrome.19173287
Mutation-Negative Lynch Syndrome, Lynch SyndromeEpigenetic AlterationsLarge genomic deletions (mainly MSH2) and germline epimutations (MLH1) together explain a significant fraction of point mutation-negative families suspected of Lynch syndrome and are associated with characteristic clinical and family features.19173287
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsTo investigate the methylation frequencies of multiple tumor suppressor genes (TSGs) in hepatocellular carcinoma (HCC) and the clinical implication of aberrant DNA methylation in molecular carcinogenesis of HCC.19173828
Liver carcinomaEpigenetic AlterationsDifferent frequency of methylation in hepatocellular carcinomas, adjacent liver tissues and cirrhotic livers implies that epigenetic alteration in the hepatocellular carcinogenesis may be a gradually progressive process.19173828
Stomach CarcinomaEpigenetic AlterationsDifferential expression of microRNA species in human gastric cancer versus non-tumorous tissues.19175831
Stomach CarcinomaEpigenetic AlterationsThe global miRNA expression profile of gastric cancer has not been reported.19175831
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in carcinogenesis.19175831
Stomach Carcinoma, MIR20A geneEpigenetic AlterationsThe most highly expressed miRNAs in gastric cancer tissues were miR-20b, miR-20a, miR-17, miR-106a, miR-18a, miR-21, miR-106b, miR-18b, miR-421, miR-340*, miR-19a and miR-658.19175831
Stomach CarcinomaEpigenetic AlterationsTo our knowledge, this is the first report about these miRNAs associated with gastric cancer.19175831
Stomach CarcinomaEpigenetic AlterationsThis new information may suggest the potential roles of these miRNAs in the diagnosis of gastric cancer.19175831
Primary malignant neoplasmEpigenetic AlterationsTo identify a better set of DNA methylation markers to detect superficial, low grade cancer cell in urine sediment for improving cancer treatment, morbidity, and mortality.19181545
liposarcomaEpigenetic AlterationsEpigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma.19186005
Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer develops through genetic, epigenetic, and environmental events that result in uncontrolled cell proliferation.19190129
Primary malignant neoplasmEpigenetic AlterationsTransformation of normal epithelium into cancer cells involves epigenetic and genetic changes and modifications in nuclear structure and tissue architecture.19193410
Carcinogenesis, MetastasisEpigenetic AlterationsThese results suggest that the Syk gene is frequently inactivated during oral carcinogenesis and that an epigenetic mechanism may regulate loss of expression possibly leading to metastasis.19195024
Opisthorchis Viverrini-Related CholangiocarcinomaEpigenetic AlterationsIn conclusion, mechanisms of inactivation of p14(ARF), p15(INK4b), and p16(INK4a) in liver fluke-related cholangiocarcinoma are preferentially different, by which epigenetic event being the main mechanism of p14(ARF), whereas p16(INK4a) and p15(INK4b) inactivation occurs through genetic and both genetic and epigenetic events, respectively.19200577
Colorectal Cancer PathwayEpigenetic AlterationsDifferential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening.19201770
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) have been shown to offer great potential in the diagnosis of cancer.19201770
Clinical CoordinatorEpigenetic AlterationsAll the five miRNAs were validated on the plasma of 25 patients with CRC and 20 healthy controls.19201770
Carcinoma of lungEpigenetic AlterationsMicroRNAs expressed during lung cancer development are expressed in human pseudoglandular lung embryogenesis.19209007
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) play a role during mouse embryonic development and are also important in carcinogenesis.19209007
Carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsOur study lends support to the model of cancer as an alteration of normal development, as many miRNAs were similarly expressed in early human lung development and stage I-II of lung cancer development.19209007
Malignant neoplasm of gastrointestinal tractEpigenetic AlterationsThese epigenetic changes create a distinct CIMP pattern that has been linked to recurrence and survival in gastrointestinal cancers.19223509
melanomaEpigenetic AlterationsBecause epigenetic inactivation of TRGs also has been shown in malignant melanoma, we hypothesized the existence of a clinically significant CIMP in cutaneous melanoma progression.19223509
NeoplasmsEpigenetic AlterationsAberrant DAPK methylation in tumor tissues is significantly higher compared with matching normal esophageal tissues, suggesting a fundamental role of this epigenetic alteration in the pathogenesis of this disease.19224282
NeoplasmsEpigenetic AlterationsAberrant methylation of the promoter is an alternative epigenetic change in genetic mechanisms, leading to tumor suppressor gene inactivation.19224462
Myofibrillar MyopathyEpigenetic AlterationsThese findings indicate that TDP-43 not only is another protein accumulated in myofibrillar myopathies, sIBM, and IBMPFD but also likely has a role through altered microRNA processing in the abnormal protein production, modification, and accumulation in protein aggregate myopathies.19225410
Malignant Neoplasms, Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsMicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy.19228262
Non-MalignantEpigenetic AlterationsNevertheless, malignant and non-malignant tissue could clearly be differentiated by their microRNA profile.19228262
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsOnly few data are available on microRNAs in clear cell renal cell carcinoma (ccRCC).19228262
NeoplasmsEpigenetic AlterationsNo significant associations between these differentially expressed microRNAs and the clinico-pathological factors tumour stage, tumour grade and survival rate were found.19228262
Prostate Cancer PathwayEpigenetic AlterationsDNA methylation of the PITX2 gene promoter region is a strong independent prognostic marker of biochemical recurrence in patients with prostate cancer after radical prostatectomy.19233404
Prostate Cancer PathwayEpigenetic AlterationsWe evaluated DNA methylation markers for prostate cancer prognosis.19233404
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsDeoxyribonucleic acid (DNA) methylation of tumor origin can be detected in the serum/plasma of cancer patients.19240607
Colorectal Cancer PathwayEpigenetic AlterationsClinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer.19242066
Congenital MeSH qualifierEpigenetic AlterationsFurthermore, LOI of IGF2 was not associated with age, suggesting an inherited or congenital epigenetic event.19242102
Colorectal NeoplasmsEpigenetic AlterationsThe relationship between gene-specific DNA methylation in leukocytes and normal colorectal mucosa in subjects with and without colorectal tumors.19258481
CarcinogenesisEpigenetic AlterationsWe suggest that the FHIT gene may be turned off in lung carcinogenesis via other genetic or epigenetic mechanisms rather than mutations.19267103
Stomach CarcinomaEpigenetic AlterationsIn gastric cancer (GC), global and gene-specific DNA methylation changes have been demonstrated to occur.19267258
Skin lesionEpigenetic AlterationsThe increased DNA methylation associated with As exposure previously observed, and confirmed among controls in this study, may be an adaptive change because hypomethylation of leukocyte DNA is associated with increased risk for skin lesions.19270796
AdenocarcinomaEpigenetic AlterationsHigh-throughput microarray was used to measure microRNA expression levels in 122 adenocarcinoma and squamous NSCLC samples.19273703
Squamous cell carcinoma of lungEpigenetic AlterationsA microRNA-based qRT-PCR assay that measures expression of hsa-miR-205 reached sensitivity of 96% and specificity of 90% in the identification of squamous cell lung carcinomas in an independent blinded validation set.19273703
Venous Invasion, MetastasisEpigenetic AlterationsSpecifically, patients with lymph node metastasis or venous invasion showed significantly high expression of microRNA-21.19276261
Colorectal Cancer PathwayEpigenetic AlterationsHere, we show for the first time that a DNA methylation-based surrogate marker can serve as a predictor of disease recurrence in colorectal cancer.19282772
Colorectal Cancer PathwayEpigenetic AlterationsCpG island hypermethylation is a common epigenetic event in colorectal cancer.19282772
NeoplasmsEpigenetic AlterationsIn situ hybridization for the most differentially expressed miRNAs was performed to show miRNA expression in tumor cells, but not in background cells.19287466
LymphomaEpigenetic AlterationsRecent studies have shown that certain non-coding short RNAs, called miRNAs, play an important role in diffuse large B-cell lymphomas.19287466
LymphomaEpigenetic AlterationsNo significant differences were seen between germinal center and non-germinal center diffuse large B-cell lymphomas in either the total or the nodal group for any of the 15 miRNAs.19287466
Malignant NeoplasmsEpigenetic AlterationsIt is becoming increasingly clear that altered miRNA expression correlates with the pathogenesis of cancers.19287964
Colorectal Cancer PathwayEpigenetic AlterationsOver- and under-expressed microRNAs in human colorectal cancer.19287964
Carcinogenesis, Colorectal CarcinomaEpigenetic AlterationsWe identified miRNAs that were overexpressed or under-expressed in colorectal cancers and which may be correlated with colorectal carcinogenesis.19287964
Breast Cancer Cell, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are a class of small noncoding RNA genes found to be abnormally expressed in several types of cancer, suggesting a role in the pathogenesis of human cancer.19289371
Carcinoma of lungEpigenetic AlterationsExosomal microRNA: a diagnostic marker for lung cancer.19289371
Adenocarcinoma of lung (disorder)Epigenetic AlterationsThe mean miRNA concentration was 158.6 ng/mL (95% CI, 145.7-171.5) for the lung adenocarcinoma group versus 68.1 ng/mL (95% CI, 57.2-78.9) for the control group (P < .001).19289371
NeoplasmsEpigenetic AlterationsComparisons between peripheral circulation miRNA-derived exosomes and miRNA-derived tumors indicated that the miRNA signatures were not significantly different.19289371
Carcinoma of lung, Adenocarcinoma of lung (disorder)Epigenetic AlterationsThe significant difference in total exosome and miRNA levels between lung cancer patients and controls, and the similarity between the circulating exosomal miRNA and the tumor-derived miRNA patterns, suggest that circulating exosomal miRNA might be useful as a screening test for lung adenocarcinoma.19289371
AJCC tumor staging, Adenocarcinoma of lung (disorder), Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsWe evaluated the circulating levels of tumor exosomes, exosomal small RNA, and specific exosomal miRNAs in patients with and without lung adenocarcinoma, correlating the levels with the American Joint Committee on Cancer (AJCC) disease stage to validate it as an acceptable marker for diagnosis and prognosis in patients with adenocarcinoma of the lung.19289371
Breast CarcinomaEpigenetic AlterationsRobust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues.19290006
Lobular NeoplasiaEpigenetic AlterationsEpigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia.19294736
AKAP13 wt AlleleEpigenetic AlterationsWe thus propose that epigenetic silencing represents the first of the two hits required to silence both CDH1 alleles for LBC to develop.19294736
AKAP13 wt AlleleEpigenetic AlterationsBecause promoter methylation is in principle reversible, our findings suggest that chemoprevention of LBC by epigenetic drugs should be feasible.19294736
CholangiocarcinomaEpigenetic AlterationsMicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.19296468
Multiple MyelomaEpigenetic AlterationsEpigenetic dysregulation of secreted Frizzled-related proteins in multiple myeloma.19299079
Malignant NeoplasmsEpigenetic AlterationsIt is thought that altered microRNA (miRNA) expression due to various mechanisms plays a critical role in the pathogenesis of most human cancers.19306352
Multiple Myeloma, Morular Metaplasia of the EndometriumEpigenetic AlterationsTo date there is little evidence concerning miRNA expression in multiple myeloma (MM).19306352
NeoplasmsEpigenetic AlterationsWe identified 16 miRNAs mapped to chromosomal regions frequently involved in numerical imbalances in MM, whose expression significantly correlated with the CN of the corresponding miRNA genes; among these, miR-22 expression was also affected by chromosome arm 17p loss in a representative panel of primary MM tumors.19306352
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsValproic acid is a clinically relevant HDAC inhibitor, and PBMCs may serve as a surrogate for tumor histone acetylation in solid tumor malignancies.19318486
Malignant neoplasm of gastrointestinal tractEpigenetic AlterationsmicroRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells.19318487
NeoplasmsEpigenetic AlterationsRecent evidence has shown that some miRNAs can act as oncogenes or tumor suppressors.19318487
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsExpression of 250 human mature miRNAs was measured by real-time PCR on paraffin-embedded tumor samples of 21 patients with gastric cancer stage III uniformly treated with surgical resection followed by chemoradiation.19318487
Pancreatic carcinoma, NeoplasmsEpigenetic Alterationslet-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression.19323605
NeoplasmsEpigenetic AlterationsRestoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation, K-ras expression, and mitogen-activated protein kinase activation, but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA.19323605
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs are potent inhibitors of protein translation, and aberrantly expressed in many cancers.19323605
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsApplying the model to population-based cancer registry data worldwide, 2 biologically relevant estimates are derived, namely the proportion of susceptible individuals and the number of genetic and epigenetic events required for the tumor to develop.19329819
NCI CTEP SDC Oligodendroglial Tumors Sub-Category TerminologyEpigenetic AlterationsCorrelation among pathology, genetic and epigenetic profiles, and clinical outcome in oligodendroglial tumors.19330828
Oligodendroglial Neoplasm, NeoplasmsEpigenetic AlterationsRecent studies have revealed a correlation between specific genetic changes, such as loss of chromosome 1p and 19q, and sensitivity of oligodendroglial neoplasm to radiotherapy and chemotherapy; epigenetic changes also play an important role in some tumors.19330828
Primary malignant neoplasmEpigenetic AlterationsTo assess the medical applicability of CpG methylation as molecular markers for cancer diagnosis, we established a new system to determine DNA methylation based on TaqMan PCR combined with a methyl-binding-domain polypeptide 2.19332050
DiseaseEpigenetic AlterationsA role of microRNA, which are approximately 22-nucleotide noncoding RNAs, has recently been recognized in human diseases.19333945
Degenerative polyarthritisEpigenetic AlterationsExpression of MicroRNA-146a in osteoarthritis cartilage.19333945
melanoma, NeoplasmsEpigenetic AlterationsThe expression of RUNX3 mRNA and miR-532-5p (microRNA) was assessed in melanoma lines and in primary and metastatic melanoma tumors.19336521
NeoplasmsEpigenetic AlterationsAberrant DNA methylation in thymic epithelial tumors.19340654
Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation plays a critical role in the development and progression of many types of cancer.19340654
Primary malignant neoplasmEpigenetic AlterationsCancer cells exhibit alterations in histone modification patterns at individual genes and globally at the level of single nuclei in individual cells.19349354
Malignant NeoplasmsEpigenetic AlterationsGlobal levels of histone modifications predict prognosis in different cancers.19349354
NeoplasmsEpigenetic AlterationsThe predictive power of these histone modifications was independent of tissue-specific clinicopathological variables, the proliferation marker Ki-67, or a p53 tumor suppressor mutation.19349354
aggressive cancerEpigenetic AlterationsChromatin immunoprecipitation experiments indicated that the lower cellular levels of histone modifications in more aggressive cancer cell lines correlated with lower levels of modifications at DNA repetitive elements but not with gene promoters across the genome.19349354
Adenocarcinoma, aggressive cancerEpigenetic AlterationsOur results suggest that lower global levels of histone modifications are predictive of a more aggressive cancer phenotype, revealing a surprising commonality in prognostic epigenetic patterns of adenocarcinomas of different tissue origins.19349354
Neoplastic diseaseEpigenetic AlterationsEpigenetic inactivation of O(6)-methylguanine-DNA methyltransferase has been found in human neoplasia and is considered one of the implicated factors in chemoresistance.19356788
PathologyEpigenetic AlterationsImpaired miRNA target binding resulting from SNPs within mRNA target sites has been shown to lead to pathologies associated with dysregulated gene expression.19363479
hearing impairment, AutosomeEpigenetic AlterationsHere we show that point mutations in the seed region of miR-96, a miRNA expressed in hair cells of the inner ear, result in autosomal dominant, progressive hearing loss.19363479
Malignant NeoplasmsEpigenetic AlterationsHuman microRNA-141 (miR-141), a member of the miR-200 family, has been reported to be associated with various human malignancies.19363643
Glioblastoma Multiforme PathwayEpigenetic AlterationsWe previously reported the epigenetic silencing of paternally expressed gene 3 (PEG3) in glioma cell lines.19367087
Glioblastoma MultiformeEpigenetic AlterationsThe lower gene expression, which suggested epigenetic silencing of PEG3, was confirmed statistically in glioblastoma using quantitative reverse-transcription polymerase chain reaction.19367087
Breast Cancer CellEpigenetic AlterationsAberrations in the DNA methylation patterns are currently recognized as a hallmark of human cancer.19368954
Coronary Artery DiseaseEpigenetic AlterationsEffect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease.19371267
Carcinogenesis, NeoplasmsEpigenetic AlterationsThe characterization of miRNA profiles in human tumors is crucial for the understanding of carcinogenesis processes, finding of new tumor markers, and discovering of specific targets for the development of innovative therapies.19372056
Dementia, DiscordanceEpigenetic AlterationsNeuropathological discordance in type of dementia among monozygotic pairs hints at environmental or epigenetic factors playing a role in Lewy body pathology.19372291
Stomach CarcinomaEpigenetic AlterationsSensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes.19375421
Carcinogenesis, Stomach NeoplasmsEpigenetic AlterationsAberrant DNA methylation is an early and frequent process in gastric carcinogenesis and could be useful for detection of gastric neoplasia.19375421
Stomach CarcinomaEpigenetic AlterationsAdditionally, we have developed a new method for gastric cancer detection by DNA methylation in gastric washes.19375421
Malignant neoplasm of urinary bladderEpigenetic AlterationsIdentification of novel microRNA targets based on microRNA signatures in bladder cancer.19378336
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsTo identify miRNAs that have a tumor suppressive function in bladder cancer (BC), 156 miRNAs were screened in 14 BCs, 5 normal bladder epithelium (NBE) samples and 3 BC cell lines.19378336
Growth retardation, NeoplasmsEpigenetic AlterationsIn addition, significant decreases in cell growth were observed after transfection of 3 miRNAs and si-KRT7 in KK47, suggesting that miR-30-3p, miR-133a and miR-199a* may have a tumor suppressive function through the mechanism underlying transcriptional repression of KRT7.19378336
Lupus ErythematosusEpigenetic AlterationsIL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation.19380809
Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsFrom normal epithelium to DCIS, there was a marked reduction in histone acetylation (P < 0.0001).19383825
Peripheral Blood Stem Cells, SeizuresEpigenetic AlterationsThe upregulation of DNMT-1 and to a lesser extent that of DNMT-3a mRNA in PBL of SZP supports the concept that this readily available peripheral cell type can express an epigenetic variation of specific biomarkers relevant to SZ morbidity.19386473
Leukemia, Myelocytic, AcuteEpigenetic AlterationsOur results indicate a function of the epigenetic regulation of the Wnt pathway in predicting relapse in a subgroup of AML patients.19387464
NeoplasmsEpigenetic AlterationsDifferentially expressed miRNAs were found in tumor samples compared with normal sample.19396864
Neurofibromatosis 2Epigenetic AlterationsTarget genes for these miRNAs include the most frequently affected genes in MM such as CDKN2A, NF2, JUN, HGF, and PDGFA.19396864
Malignant Neoplasms, Squamous cell carcinoma, SERPINB3 wt AlleleEpigenetic AlterationsAltered microRNA (miRNA) expression profiles have been observed in numerous malignancies, including oral squamous cell carcinoma (OSCC).19396866
SERPINB3 wt Allele, LossEpigenetic AlterationsWe hypothesize that the expression of miRNAs mapping to 11q are altered in OSCC because of loss or amplification of chromosomal material, and that this contributes to the development and progression of OSCC.19396866
Stomach Carcinoma, CarcinogenesisEpigenetic AlterationsDNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis.19399343
Stomach CarcinomaEpigenetic AlterationsDNA methylation identified subgroups of diffuse type gastric cancer.19399343
CDISC SDTM Lesion Complexity TerminologyEpigenetic AlterationsMicro-RNA (miRNA) mediated regulation of messenger RNA (mRNA) complexity in the central nervous system (CNS) is emerging as a critical factor in the control of CNS-specific gene expression during development, plasticity, aging and disease.19406203
Leukocyte adhesion deficiency type 1Epigenetic AlterationsThe results suggest (a) that unless specifically stabilized, certain brain-enriched miRNAs represent a rapidly executed signaling system employing highly transient effectors of CNS gene expression, and (b) that in AD temporal lobe neocortex specific brain miRNAs are significantly up-regulated in abundance and strongly correlate with the presence of AD-type neuropatholgical change.19406203
NeoplasmsEpigenetic AlterationsELISA, real-time qPCR and immunocytochemical staining demonstrated that adenoviral-vector based siRNA decreased angiogenin mRNA level and protein secretion, and inhibited angiogenin nuclear expression in A549 cells, resulting in marked inhibition on ribosomal RNA transcription, in vitro cell proliferation, soft agar colony formation, and xenograft tumor proliferation and angiogenesis.19423182
Breast CarcinomaEpigenetic AlterationsMicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer.19432961
Breast CarcinomaEpigenetic AlterationsExpression profiling of 453 miRNAs was performed in 29 early-stage breast cancer specimens.19432961
Breast CarcinomaEpigenetic AlterationsThe association of specific miRNAs with ER, PR and HER2/neu status indicates a role for these miRNAs in disease classification of breast cancer.19432961
CarcinogenesisEpigenetic AlterationsTFPI2 belongs to the recently described group of embryonic cell Polycomb group (PcG)-marked genes that may be predisposed to aberrant DNA methylation in early stages of colorectal carcinogenesis.19435926
Malignant neoplasm of stomachEpigenetic AlterationsDecreased expression of microRNA-143 and -145 in human gastric cancers.19439999
Stomach CarcinomaEpigenetic AlterationsThe growth inhibitory effect was estimated by the transfection of human gastric cancer cells with the miRNA.19439999
NeoplasmsEpigenetic AlterationsDownregulation of specific microRNAs (miRNAs) occurs in human tumors, which suggests a function for miRNAs in tumor suppression.19439999
ovarian neoplasm, NeoplasmsEpigenetic AlterationsTumor microRNA expression patterns associated with resistance to platinum based chemotherapy and survival in ovarian cancer patients.19446316
NeoplasmsEpigenetic AlterationsSeven microRNAs were found to be significantly differentially expressed in tumors from platinum-sensitive vs. platinum-resistant patients (p<0.05).19446316
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAltered miRNA expression in sputum for diagnosis of non-small cell lung cancer.19446359
Non-Small Cell Lung CarcinomaEpigenetic Alterationsexpressions of mature miRNAs, mir-21 and mir-155, were examined by real-time reverse transcription polymerase chain reaction (RT-PCR) and normalized to that of control miRNA, U6B, in sputum of 23 patients with NSCLC and 17 cancer-free subjects.19446359
Carcinoma of lungEpigenetic AlterationsThe measurement of altered miRNA expression in sputum could be a useful noninvasive approach for the diagnosis of lung cancer.19446359
Carcinoma of lungEpigenetic AlterationsMicroRNAs (miRNAs) are small regulatory RNAs that are frequently dysregulated in lung cancer and have shown promise as tissue-based markers for its prognostication.19446359
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsPhospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer.19448674
Upper aerodigestive tractEpigenetic AlterationsWe identified PLCD1 as a downregulated gene in aerodigestive carcinomas through expression profiling and epigenetic characterization.19448674
Stomach Carcinoma, Carcinogenesis, NeoplasmsEpigenetic AlterationsThus, epigenetic inactivation of PLCD1 is common and tumor-specific in gastric cancer, and PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis.19448674
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe effects of folate supplementations were analyzed on the global DNA methylation status, the methylation status of DNA repeat element, the sensitivity of temozolomide-induced apoptosis, and the proliferation index of glioma cells.19451595
Glioblastoma Multiforme PathwayEpigenetic AlterationsFinally, we show that the folate-induced DNA methylation limits proliferation and increases the sensitivity to temozolomide-induced apoptosis in glioma cells through methylation of the genes implicated in these processes (PDGF-B, MGMT, survivin, and bcl-w).19451595
Prostate Cancer PathwayEpigenetic AlterationsDNA methylation biomarkers of prostate cancer: confirmation of candidates and evidence urine is the most sensitive body fluid for non-invasive detection.19459176
Malignant NeoplasmsEpigenetic AlterationsPolymorphisms of the DNMT3B gene may influence its activity on DNA methylation in several cancers, thereby modulating susceptibility to tumorigenesis.19465161
Primary malignant neoplasmEpigenetic AlterationsNew therapeutic agents, such as DNA methylation inhibitors, could be useful against this dramatic cancer.19465885
Liver carcinomaEpigenetic AlterationsUp-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression.19472311
Liver neoplasmsEpigenetic AlterationsMoreover, we show that overexpression of this miRNA is transcribed by nuclear factor kappa B (NF-kappaB) and favors liver tumor cell invasive and metastatic behavior.19472311
Malignant neoplasm of esophagusEpigenetic AlterationsThe presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers.19472401
Squamous cell carcinoma of esophagusEpigenetic AlterationsEsophageal squamous cell carcinomas (ESCCs) tend to have multiple primary lesions, and it is believed that they arise from background mucosae with accumulation of genetic/epigenetic alterations.19472401
Bladder NeoplasmEpigenetic AlterationsOur data suggest that instead of up-regulation of carcinogenic miRNAs, loss of regulation of these miRNA may be critical for bladder tumor development in patients.19475496
Bladder NeoplasmEpigenetic AlterationsMicroRNAs (miRNAs) have recently been shown to down-regulate gene expression by targeting mRNA translation and to play a critical role in tumorigenesis; how they regulate bladder tumor development, particularly in patients, is, however, poorly understood.19475496
Hepatitis AEpigenetic AlterationsEpigenetic factors may modulate chronic Hepatitis B viral infection by affecting virion gene transcription.19475606
Liver carcinomaEpigenetic AlterationsMicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells.19490101
DiseaseEpigenetic AlterationsDNA methylation is an important component of epigenetic modifications, which influences the transcriptional machinery aberrant in many human diseases.19491193
Primary malignant neoplasmEpigenetic AlterationsTrophoblast cells and many cancer cells that harbor foreign antigens may evade immunity by epigenetic silencing of key immune response genes, including MHC class I and II and CD40.19493573
Carcinoma of lungEpigenetic AlterationsTransfected cell viability assays were applied to determine the effects of candidate miRNAs on lung cancer cells.19493678
Carcinoma of lung, MIR183 wt AlleleEpigenetic AlterationsComparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs.19493678
Malignant mesotheliomaEpigenetic AlterationsMicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications.19502386
MesotheliomaEpigenetic AlterationsHere we report, for the first time, a cross-evaluation of miRNA expression in mesothelioma (MPP-89, REN) and human mesothelial cells (HMC-telomerase reverse transcriptase).19502386
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) post-transcriptionally regulate the expression of target genes, and may behave as oncogenes or tumor suppressors.19502386
MesotheliomaEpigenetic AlterationsMicroarray profiling, confirmed by real-time quantitative RT-PCR, revealed a differential expression of miRNAs between mesothelioma and mesothelial cells.19502386
MesotheliomaEpigenetic AlterationsThis suggests that miRNAs may be key players in mesothelioma oncogenesis.19502386
insulinomaEpigenetic AlterationsWe have previously demonstrated that epigenetic changes are an early event in a mouse model developing insulinomas.19502451
Malignant NeoplasmsEpigenetic AlterationsAlterations of DNA methylation patterns have been suggested as biomarkers for diagnostics and therapy of cancers.19503099
Non-Small Cell Lung CarcinomaEpigenetic AlterationsTo identify the DNA methylation biomarkers for the detection of the stage I non-small cell lung cancer (NSCLC).19506903
Trauma Symptom Checklist for Children QuestionnaireEpigenetic AlterationsMicroRNA profiling was done in 10 cases of TSCC with microarray.19509158
SERPINB3 wt Allele, NeoplasmsEpigenetic AlterationsOur study indicates that epigenetic silencing of tumor suppressor genes involved in the Ras/PI3K/AKT pathway plays an important role in OSCC radioresistance and this provides a rationale for exploring novel treatment strategies.19509163
S100A4 protein, humanEpigenetic AlterationsTo develop a timeline of aberrant DNA methylation events during malignant transformation, we analyzed genome-wide DNA methylation patterns in an isogenic human mammary epithelial cell (HMEC) culture model of transformation.19509227
StasisEpigenetic AlterationsThe first aberrant DNA methylation step coincides with overcoming stasis, and results in few to hundreds of changes, depending on how stasis was overcome.19509227
Breast Carcinoma, CarcinogenesisEpigenetic AlterationsThese results show that large-scale epigenetic remodeling occurs in the earliest steps of mammary carcinogenesis, temporally links DNA methylation changes and overcoming cellular proliferation barriers, and provides a bank of potential epigenetic biomarkers that may prove useful in breast cancer risk assessment.19509227
Carcinogenesis, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur data demonstrate that DNA methylation and histone methylation analysis of the ICR within the DMR of IGF2/H19 provides important insights into early steps of carcinogenesis and, therefore, may contribute to improving diagnosis of PCa.19513555
Prostate Cancer Pathway, Prostatic HyperplasiaEpigenetic AlterationsAberrant epigenetic modifications in the CTCF binding domain of the IGF2/H19 gene in prostate cancer compared with benign prostate hyperplasia.19513555
Malignant neoplasm of breast, Breast CarcinomaEpigenetic AlterationsTranscriptional inactivation of breast cancer gene 1 (BRCA1) by DNA methylation is a frequent event in sporadic breast cancers.19522853
Colorectal Cancer PathwayEpigenetic AlterationsThese results indicated that epigenetic demethylation of the CDH3 promoter in the human intestine permits its ectopic expression in colorectal cancer.19528483
Multiple MyelomaEpigenetic AlterationsDifferential repetitive DNA methylation in multiple myeloma molecular subgroups.19531770
GlioblastomaEpigenetic AlterationsEpigenetic silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) by promoter methylation is associated with improved survival in glioblastomas treated with alkylating agents.19536096
Squamous cell carcinoma of esophagusEpigenetic AlterationsWe examined the correlation between miRNA expressions and the clinicopathological factors and prognosis of ESCC.19536617
Squamous cell carcinoma of esophagusEpigenetic AlterationsExpression profiling of micro-RNAs in human esophageal squamous cell carcinoma using RT-PCR.19536617
Myeloid Leukemia, Chronic, Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe frequencies of DNA methylation of ID4, SFRP1, and SHP1 were higher in AML patients compared to those in CML patients.19543515
Glioblastoma MultiformeEpigenetic AlterationsThese results suggested that epigenetic inactivation of MGMT plays an important role in the survival of glioblastoma patients and this inactivated gene involved in p53 mutation.19544111
NeoplasmsEpigenetic AlterationsThe presence of epigenetic lesions, like hypermethylation of known tumor suppressor genes such as MGMT, has been widely described in GBM, but to our knowledge, a genome-wide profile of DNA methylation changes in these lethal tumors is not yet available.19550145
Pancreatic NeoplasmEpigenetic AlterationsElevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival.19551852
Pancreatic NeoplasmEpigenetic AlterationsThese microRNAs were chosen as they had previously been shown to be differentially expressed in pancreatic tumors compared to normal tissues.19551852
Neoplasms, Cancer PainEpigenetic AlterationsFurthermore, tumors from patients demonstrating elevated expression levels of all 4 microRNAs possessed a 6.2-fold increased risk of tumor-related death compared to patients whose tumors showed a lower expression of these microRNAs.19551852
NeoplasmsEpigenetic AlterationsFurthermore, the putative target genes for these microRNAs suggest a complex signaling network that can affect PDAC tumorigenesis and tumor progression.19551852
NeoplasmsEpigenetic AlterationsAs transcriptional regulators, altered miRNA expression may affect many cancer-related biological pathways, indicating that miRNAs can function as tumor suppressors and/or oncogenes.19567675
Breast CarcinomaEpigenetic AlterationsBy delivering expression vectors containing either wild-type or mutant precursors of miR-196a-2 into breast cancer cells, we showed that this variant led to less efficient processing of the miRNA precursor to its mature form as well as diminished capacity to regulate target genes.19567675
Obesity, Malignant neoplasm of esophagusEpigenetic AlterationsThese findings suggest that G1013A most likely modulates IGF-IR function, possibly by influencing gene transcription or mRNA stability, and represents a plausible mechanistic link underlying the association between obesity and esophageal malignancy.19582762
NeoplasmsEpigenetic AlterationsThese epigenetic signatures may represent an additional mechanism to promote and maintain a hypoxic-adapted cellular phenotype with a potential role in tumour development.19584087
Squamous cell carcinoma of lungEpigenetic AlterationsMicroRNA classifiers for predicting prognosis of squamous cell lung cancer.19584273
AdenocarcinomaEpigenetic AlterationsWe also identified miRNAs, including miR-155 and let-7, which had previously been shown to have prognostic value in adenocarcinoma.19584273
Squamous cell carcinoma of lungEpigenetic AlterationsOur data indicate that miRNAs may have greater clinical utility in predicting the prognosis of patients with squamous cell lung carcinomas than mRNA-based signatures.19584273
NeoplasmsEpigenetic AlterationsThis short lifespan would prevent the accumulation of somatic genetic mutations or epigenetic alterations necessary for tumor progression.19584276
Primary malignant neoplasmEpigenetic AlterationsThe identification of target genes is a key step for assessing the role of aberrantly expressed microRNAs (miRNA) in human cancer and for the further development of miRNA-based gene therapy.19584283
Hollings Cancer CenterEpigenetic AlterationsOur findings establish a basis toward the development of combined chemo- and miRNA-based therapy for HCC treatment.19584283
Aggressive behavior, MetastasisEpigenetic AlterationsExpression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence.19585579
Malignant Neoplasms, CHOANAL ATRESIA, POSTERIOR, Prostate carcinomaEpigenetic AlterationsEmerging evidence shows that microRNAs (miR) are involved in the pathogenesis of a variety of cancers, including prostate carcinoma (PCa).19585579
Lymphoma, FollicularEpigenetic AlterationsArray-based DNA methylation profiling in follicular lymphoma.19587707
CarcinogenesisEpigenetic AlterationsMoreover, folate insufficiency can induces carcinogenesis by decreasing DNA methylation.19588544
Glioblastoma MultiformeEpigenetic AlterationsIn glioblastoma, low O(6)-methylguanine DNA methyltransferase (MGMT) expression is associated with epigenetic gene silencing and predicts a better response to temozolomide.19589911
Breast AdenocarcinomaEpigenetic AlterationsDNA methylation of K(v)1.3 potassium channel gene promoter is associated with poorly differentiated breast adenocarcinoma.19590190
Breast CarcinomaEpigenetic AlterationsDNA methylation is an important mechanism for gene silencing and has already been described for several genes in breast cancer.19590190
Breast Adenocarcinoma, NeoplasmsEpigenetic AlterationsOur data suggest that DNA methylation is responsible for a decrease of K(v)1.3 gene expression in breast adenocarcinoma and is associated with poorly differentiated tumors and younger patients.19590190
NeoplasmsEpigenetic AlterationsRecent work has shown that these miRNA expression patterns can be used to classify tumor cells, and that this classification can be more accurate than the classification achieved by using messenger RNA gene expression patterns.19597549
Primary malignant neoplasmEpigenetic AlterationsDetection of cancer with serum miRNAs on an oligonucleotide microarray.19597549
NeoplasmsEpigenetic AlterationsAltered expression of specific miRNAs in several tumor types has been reported.19598010
Fibroid Tumor, NeoplasmsEpigenetic AlterationsRecently it has been shown that repression of HMGA2 by microRNA let-7s is a critical molecular regulatory mechanism associated with tumour growth in many tumours and cell types, including leiomyomas.19602040
Primary malignant neoplasmEpigenetic AlterationsDNA methylation occurs predominantly at cytosines that precede guanines in dinucleotide CpG sites; it is one of the most important mechanisms for epigenetic DNA regulation during normal development and for aberrant DNA in cancer.19606065
Pick Disease of the Brain, Frontotemporal Lobar Degeneration, Parkinson Disease, Lewy Bodies, Brain Diseases, Motor Neuron Disease, Dementia, "Alzheimers DiseaseEpigenetic AlterationsDNA methylation was analyzed in selected regions of MAPT, APP, and PSEN1 in the frontal cortex and hippocampus of controls (n=26) and those with Alzheimer disease at Stages I to II (n=17); Alzheimer disease at Stages III to IV (n=15); Alzheimer disease at Stages V to VI (n=12); argyrophilic grain disease (n=10); frontotemporal lobar degeneration linked to tau mutations (n=6); frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions (n=4); frontotemporal lobar degeneration with motor neuron disease (n=3); Pick disease (n=3); Parkinson disease (n=8); dementia with Lewy bodies, pure form (n=5); and dementia with Lewy bodies, common form (n=15).19606065
Degenerative disorderEpigenetic AlterationsBecause small changes in methylation of DNA promoters in vulnerable cells might have not been detected in total homogenates, however, these results should be interpreted with caution, particularly as they relate to chronic degenerative diseases in which small modifications may be sufficient to modulate disease progression.19606065
CarcinogenesisEpigenetic AlterationsOur results suggest that epigenetic inactivation of hMLH1 might play a role in the carcinogenesis of MSI-H gastric carcinomas.19621725
NeoplasmsEpigenetic AlterationsAberrant DNA methylation has the potential of being a tumor marker.19622308
Glioblastoma MultiformeEpigenetic AlterationsEpigenetic silencing of the MGMT gene by promoter methylation has been associated with longer survival in patients with newly diagnosed glioblastoma multiforme (GBM) who receive alkylating agents.19637364
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsEpigenetic changes play a role and cooperate with genetic alterations in the pathogenesis of myelodysplastic syndromes (MDS).19638460
Malignant Pleural Mesothelioma, Adenocarcinoma of lung (disorder)Epigenetic AlterationsDifferentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles.19638575
Colorectal Cancer PathwayEpigenetic AlterationsA human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer.19640954
NeoplasmsEpigenetic AlterationsAberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia.19641183
melanoma, NeoplasmsEpigenetic AlterationsTaken together, the present report indicates that epigenetic silencing of 14-3-3sigma might contribute to tumor progression in malignant melanoma via loss of cell cycle control, impaired cellular senescence program and support of migratory capacity.19642975
Breast CarcinomaEpigenetic AlterationsClinical significance of epigenetic inactivation of hMLH1 and BRCA1 in Tunisian patients with invasive breast carcinoma.19644562
Breast CarcinomaEpigenetic AlterationsHowever, epigenetic silencing of CXCL12 has recently been reported to increase the metastatic potential of breast cancer cells and the reintroduction of the cytokine gene into MDA-MB-231 breast carcinoma cells decreases the number of metastases formed in vivo.19646861
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLack of prognostic significance of serum DNA methylation of DAPK, MGMT, and GSTPI in patients with non-small cell lung cancer.19653236
NeoplasmsEpigenetic AlterationsThere were no associations between DNA methylation status and histology, tumor stage, grading or gender detectable.19653236
Metastasis, CholangiocarcinomaEpigenetic AlterationsAberrant DNA methylation of integrin alpha4: a potential novel role for metastasis of cholangiocarcinoma.19655168
MetastasisEpigenetic AlterationsMoreover, we found that DNA methylation of integrin alpha4 was detected in all CC tissues obtained from patients with LN metastasis (7/7).19655168
MetastasisEpigenetic AlterationsTaken together, these results suggest that loss of the integrin alpha4 gene is caused by aberrant DNA methylation of the 5-CpG island site of the gene, and methylation of the integrin alpha4 gene can be a useful marker of metastasis of CC.19655168
AllergicEpigenetic AlterationsReal-time PCR confirmed the observed increase in Th2 cytokine gene transcription in allergic patients.19657353
Malignant tumor of colon, MetastasisEpigenetic AlterationsMicroRNA expression profile in non-cancerous colonic tissue associated with lymph node metastasis of colon cancer.19659786
Malignant tumor of colon, MetastasisEpigenetic AlterationsTo identify microRNA expression patterns associated with the lymph node metastasis of colon cancer.19659786
Malignant tumor of colon, MetastasisEpigenetic AlterationsMicroRNA were isolated from six frozen non-cancerous surrounding colonic tissues derived from stage II-III colon cancer patients with (n = 3) and without (n = 3) lymph node metastasis.19659786
Malignant tumor of colon, MetastasisEpigenetic AlterationsThe differentially expressed microRNA could have relevance to the lymph node metastasis of colon cancer and may provide a simple profiling method to assist in identifying patients with lymph node metastasis.19659786
CarcinogenesisEpigenetic AlterationsThe enzyme MTHFR plays an important role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair, and synthesis.19669769
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsAssociation of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy.19669769
High-Frequency Microsatellite Instability, Primary malignant neoplasmEpigenetic AlterationsWe assessed MSI-H and other genetic and epigenetic changes on survival of 990 individuals diagnosed with first primary rectal cancer.19669908
Malignant Neoplasms, High-Frequency Microsatellite Instability, NeoplasmsEpigenetic AlterationsThe genetic and epigenetic characteristics of MSI-H rectal cancers suggest that they are enriched for Lynch-associated tumors; adverse prognosis associated with MSI-H in these tumors may reflect the relatively high frequency of Lynch-associated cancers and/or the effect of radiation or chemotherapy on Lynch-associated rectal cancers or MSI tumors in general.19669908
Hepatitis CEpigenetic AlterationsComputational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers.19671175
Hepatitis CEpigenetic AlterationsWe propose an integrative strategy for identifying the miRNA-mRNA regulatory modules that are associated with HCV infection.19671175
DiseaseEpigenetic AlterationsThis report demonstrates the utility of our approach to obtain new insights into post-transcriptional gene regulation at the miRNA level in complex human diseases.19671175
Liver carcinoma, Tumor focalityEpigenetic AlterationsMicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality.19671867
HepatocarcinogenesisEpigenetic AlterationsMicroRNAs participate in the modulation of key molecules linked to hepatocarcinogenesis.19671867
Primary malignant neoplasmEpigenetic AlterationsAccumulating evidence suggests that DNA methylation markers could serve as sensitive and specific cancer biomarkers.19674832
Prostate carcinomaEpigenetic AlterationsDiagnostic and prognostic implications of microRNA profiling in prostate carcinoma.19676045
miR-181b, human, MIR183 wt AlleleEpigenetic AlterationsTen microRNAs (hsa-miR-16, hsa-miR-31, hsa-miR-125b, hsa-miR-145, hsa-miR-149, hsa-miR-181b, hsa-miR-184, hsa-miR-205, hsa-miR-221, hsa-miR-222) were downregulated and 5 miRNAs (hsa-miR-96, hsa-miR-182, hsa-miR-182, hsa-miR-183, hsa-375) were upregulated.19676045
NeoplasmsEpigenetic AlterationsExpression of 5 miRNAs correlated with Gleason score or pathological tumor stage.19676045
Prostate Cancer PathwayEpigenetic AlterationsThus, differential miRNAs in prostate cancer are useful diagnostic and prognostic indicators.19676045
Breast CarcinomaEpigenetic AlterationsEpigenetics alterations of the 14-3-3 sigma can contribute to reducing or losing expression of 14-3-3 sigma protein, which play an important role in the development of sporadic breast carcinomas and involved in various types, grades, and lymph node metastases.19685192
Primary malignant neoplasmEpigenetic AlterationsSimilar epigenomic and epigenetic events were frequently observed within a synchronous cancer pair, suggesting the presence of a field defect.19686742
Malignant tumor of colonEpigenetic AlterationsPost-transcriptional regulation mediated by RNA-binding proteins or microRNAs coordinately targets multiple genes, holding promise involved in colon cancer initiation and development.19686745
Autoimmune DiseasesEpigenetic AlterationsEpigenetics may influence the expression of numerous genes, which might contribute to autoimmune diseases.19696477
Malignant Neoplasms, Adenocarcinoma of pancreasEpigenetic AlterationsWe hypothesized that if aberrantly expressing microRNAs (miRNA) in pancreatic adenocarcinoma tissues are detected in blood plasma, then plasma profiling of these miRNAs might serve as a minimally invasive early detection biomarker assay for this malignancy.19723895
Adenocarcinoma of pancreasEpigenetic AlterationsBy using a modified protocol to isolate and quantify plasma miRNAs from heparin-treated blood, we show that miRNA profiling in plasma can differentiate pancreatic adenocarcinoma patients from healthy controls.19723895
Pancreatic carcinomaEpigenetic AlterationsThese observations, although a "proof of principle" finding at this time, show the feasibility of developing plasma miRNA profiling as a sensitive and specific blood-based biomarker assay for pancreatic cancer that has the potential of translation to the clinic with additional improvements in the future.19723895
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsMicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease.19723895
Pancreatic carcinomaEpigenetic AlterationsWe have profiled four miRNAs, miR-21, miR-210, miR-155, and miR-196a, all implicated in the development of pancreatic cancer with either proven or predicted target genes involved in critical cancer-associated cellular pathways.19723895
Gammopathy, NeoplasmsEpigenetic AlterationsDNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance.19727727
Neoplastic diseaseEpigenetic AlterationsSpecific epigenetic changes in normal colonic mucosa may be correlated with the occurrence and development of neoplasia in the distal colon.19733896
Adenocarcinoma, Clear Cell, Adenocarcinoma, Oxyphilic, FLCN protein, human, NeoplasmsEpigenetic AlterationsAdditional molecular genetic testing revealed somatic mutations and epigenetic events in genes typically associated with these specific histologic tumor types: oncocytoma harbored a second FLCN mutation (intron 12, IVS12+4 C>T), oncocytic papillary carcinoma harbored promoter methylation of FLCN, and a missense mutation in the MET gene (P246L), whereas clear cell carcinoma harbored inactivating VHL mutation (5-base pair deletion in exon 2) and VHL gene promoter methylation.19733897
Colorectal Cancer PathwayEpigenetic AlterationsWe show that the T allele at SNP rs16906252 is a key determinant in the onset of MGMT methylation in colorectal cancer, whereas the association of methylation at MGMT and CDKN2A suggests that these loci may be targets of a common mechanism of epigenetic dysregulation.19734844
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) have been identified as promising prognostic markers in non-small-cell lung cancer (NSCLC) since they play an important role in oncogenesis.19736307
Adenocarcinoma of colonEpigenetic AlterationsAssociation of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma.19737943
Malignant tumor of colon, CarcinogenesisEpigenetic AlterationsInflammatory genes and microRNAs have roles in colon carcinogenesis; therefore, they may provide useful biomarkers for colon cancer.19737943
Barrett EsophagusEpigenetic AlterationsMicroRNA expression signatures in Barretts esophagus and esophageal adenocarcinoma.19737949
Malignant Neoplasms, Adenocarcinoma Of EsophagusEpigenetic AlterationsAlthough microRNA (miRNA) expression signatures have been associated with the etiology and prognosis of several types of cancers, their roles in the development of esophageal adenocarcinoma have not been extensively evaluated.19737949
Barretts esophagus with low grade dysplasiaEpigenetic AlterationsFinally, we identified several miRNAs that were involved in the progressions from low grade-dysplasia Barretts esophagus to esophageal adenocarcinoma.19737949
Adenocarcinoma Of EsophagusEpigenetic AlterationsWe showed that miRNAs were involved in the development and progression of esophageal adenocarcinoma.19737949
Esophageal carcinomaEpigenetic AlterationsThe identified significant miRNAs that may become potential targets for early detection, chemoprevention, and treatment of esophageal cancer.19737949
Colorectal CarcinomaEpigenetic AlterationsConcordant DNA methylation in synchronous colorectal carcinomas.19737982
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsEpigenetic changes have been proposed as mediators of the field defect in colorectal carcinogenesis, which has implications for risk assessment and cancer prevention.19737982
Primary malignant neoplasmEpigenetic AlterationsGenomic variation within miRNA target sites may therefore be important sources for genetic differences in cancer risk.19738052
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs regulate diverse cellular processes and play an integral role in cancer pathogenesis.19738052
Oral Cavity Carcinoma, mucosa-associated lymphoid tissueEpigenetic AlterationsEpigenetic loss of mucosa-associated lymphoid tissue 1 expression in patients with oral carcinomas.19738055
Prostatic NeoplasmsEpigenetic AlterationsSystemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes.19738602
Prostate Cancer PathwayEpigenetic AlterationsHere, we show that microRNA (miR)-16, which is expressed at lower levels in prostate cancer cells, affects the proliferation of human prostate cancer cell lines both in vitro and in vivo.19738602
Prostate Cancer Pathway, Neoplasm MetastasisEpigenetic AlterationsThus, this study indicates the therapeutic potential of miRNA in an animal model of cancer metastasis with systemic miRNA injection and suggest that systemic delivery of miR-16 could be used to treat patients with advanced prostate cancer.19738602
MetastasisEpigenetic AlterationsRecent reports have linked the expression of specific microRNAs (miRNAs) with tumorigenesis and metastasis.19738602
Obesity, Pulmonary Hypertension, Thyroid DiseasesEpigenetic AlterationsThe coexistent high prevalence in our cohort of exogenous estrogen exposure, thyroid disease and obesity suggests that an interaction of multiple endocrine factors might contribute to the pathogenesis of pulmonary hypertension and may represent epigenetic modifiers in genetically-susceptible individuals.19748850
Human papilloma virus infectionEpigenetic AlterationsFolate status and aberrant DNA methylation are associated with HPV infection and cervical pathogenesis.19755648
Malignant NeoplasmsEpigenetic AlterationsAberrant DNA methylation is a recognized feature of human cancers, and folate is directly involved in DNA methylation via one-carbon metabolism.19755648
cervical cancerEpigenetic AlterationsA cross-sectional study was conducted to test the hypothesis that folate status and aberrant DNA methylation show a progressive change across stages of cervical pathology from normal cells to cervical cancer.19755648
Malignant - descriptorEpigenetic AlterationsIt appeared that CpG was unique in that it raised the membrane expression of CD20 on malignant B cells, owing to a PU.1 independent increase in its gene transcription.19758221
NeoplasmsEpigenetic AlterationsThese data indicate that tumour progression and angiogenesis are not directly influenced by VHL alterations and that additional genetic/epigenetic events should be considered to explain the diverse angiogenic and proliferative behaviour during tumour progression.19759417
Acute lymphocytic leukemiaEpigenetic AlterationsCharacterization of B- and T-lineage acute lymphoblastic leukemia by integrated analysis of MicroRNA and mRNA expression profiles.19760605
Acute lymphocytic leukemiaEpigenetic AlterationsFurthermore, we identified miR-148, miR-151, and miR-424 as discriminative of T-lineage versus B-lineage ALL; ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions.19760605
Liver carcinomaEpigenetic AlterationsAberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma.19760608
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsInvestigating aberrant DNA methylation in the cancer genome may identify genes that play an important role in tumor progression.19760608
NeoplasmsEpigenetic AlterationsMoreover, KLK10 and OXGR1 mRNA levels were inversely correlated (r = -0.435 and -0.497, P < 0.05) with DNA methylation as examined in paired adjacent normal and tumor samples.19760608
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDifferent histological types of non-small cell lung cancer have distinct folate and DNA methylation levels.19764999
Carcinoma of lungEpigenetic AlterationsAberrant DNA methylation is a commonly observed epigenetic change in lung cancer.19764999
Primary malignant neoplasmEpigenetic AlterationsFolate has been suggested to play a role in the homeostasis of DNA methylation and has also been implicated in cancer chemotherapy.19764999
Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur results suggest that folate metabolism plays a role in aberrant DNA methylation in NSCLC.19764999
Gastrointestinal Stromal TumorsEpigenetic AlterationsLocalization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31.19768731
Gastrointestinal Stromal TumorsEpigenetic AlterationsTwelve GISTs were evaluated for differential miRNA expression signatures by use of microarrays representing 734 human miRNAs.19768731
Gastrointestinal Stromal TumorsEpigenetic AlterationsmiRNA profiling may prove to be a key determinant of the biology and clinical features of GISTs.19768731
Gastrointestinal Stromal TumorsEpigenetic AlterationsDifferential expression was further analysed and confirmed for four miRNAs (miR-132, miR-221, miR-222, and miR-504) by qRT-PCR in 49 additional GISTs.19768731
Gastrointestinal Stromal Tumors, NeoplasmsEpigenetic AlterationsThis was confirmed for two selected miRNAs (miR-134 and miR-370) from the 14q32.31 cluster by qRT-PCR in 49 additional GISTs, and the expression of these two miRNAs was significantly lower in GISTs with 14q loss, and also in GISTs with tumour progress.19768731
Colorectal Cancer PathwayEpigenetic AlterationsTo identify epigenetic molecular makers in plasma for the early detection of colorectal cancer.19773381
Carcinoma, Transitional Cell, Transitional epithelial cell of urinary bladderEpigenetic AlterationsGenome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage.19775289
CarcinogenesisEpigenetic AlterationsThe combination of DNA methylation status on 83 BAC clones selected by Wilcoxon test was able to completely discriminate N from C, and diagnose N as having a high risk of carcinogenesis, with 100% sensitivity and specificity.19775289
Ulcerative ColitisEpigenetic AlterationsThe combination of DNA methylation status for 11 BAC clones selected by Wilcoxon test was able to completely discriminate patients with UCs of the renal pelvis or ureter who suffered from intravesical metachronous UC development from patients who did not.19775289
Carcinogenesis, Ulcerative Colitis, CarcinogensEpigenetic AlterationsGenome-wide alterations of DNA methylation may participate in urothelial carcinogenesis from the precancerous stage to UC, and DNA methylation profiling may provide optimal indicators for carcinogenetic risk estimation and prognostication.19775289
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsIncreased microsatellite instability and epigenetic inactivation of the hMLH1 gene in head and neck squamous cell carcinoma.19786217
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsThe study is designed to elucidate the relationship between epigenetic silencing of the hMLH1 (human MutL homologue 1) gene and microsatellite instability (MSI) and the prognostic values of hMLH1 promoter methylation and MSI in head and neck squamous cell carcinoma (HNSCC).19786217
Malignant neoplasm of larynx, NeoplasmsEpigenetic AlterationsLet-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer.19787239
Malignant Neoplasms, Malignant neoplasm of lungEpigenetic AlterationsLethal-7a (let-7a) is a founding member of miRNA family and recently it was found to be associated with several cancers, such as lung and colon cancers.19787239
Laryngeal Squamous Cell Carcinoma, Malignant neoplasm of larynxEpigenetic AlterationsIn the present study, we found that let-7a miRNA expression was significantly downregulated both in human laryngeal squamous cancer tissues and in Hep-2 cells, a laryngeal cancer cell line, as compared with adjacent normal tissues and BEAS-2B cells, respectively.19787239
Liver carcinoma, S100A4 protein, human, Hollings Cancer CenterEpigenetic AlterationsThere is significant regional variation in the etiologic agents responsible for hepatocellular carcinoma (HCC), which influences the genetic and epigenetic mechanisms of malignant transformation.19787262
Pancreatic carcinomaEpigenetic AlterationsWe have previously identified transcriptional changes in highly nerve invasive pancreatic cancer cells.19787265
Colorectal Cancer PathwayEpigenetic AlterationsGenetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer.19787768
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe primary objective of this study is to identify prognostic site-specific epigenetic changes in surgically treated Stage I and II nonsmall cell lung cancer (NSCLC) patients by quantifying methylation levels at multiple CpG sites within each gene promoter.19795445
Gastrointestinal Stromal TumorsEpigenetic AlterationsMicroRNA expression profile of gastrointestinal stromal tumors is distinguished by 14q loss and anatomic site.19795448
Gastrointestinal Stromal Tumors, NeoplasmsEpigenetic AlterationsAlthough unique microRNA expression profiles have been reported in several tumors, little is known about microRNA expression profiles in GISTs.19795448
Gastrointestinal Stromal TumorsEpigenetic AlterationsTo evaluate the relationship between microRNA expression and clinicopathologic findings of GISTs, we analyzed the microRNA expression profiles of GISTs.19795448
Gastrointestinal Stromal TumorsEpigenetic AlterationsUsing unsupervised hierarchical clustering analysis, we found four distinct microRNA expression patterns in our 20 GISTs.19795448
Gastrointestinal Stromal Tumors, NeoplasmsEpigenetic AlterationsThe microRNA expression patterns of GISTs are closely related to the status of 14q loss, anatomic site, and tumor risk.19795448
Gastrointestinal Stromal TumorsEpigenetic AlterationsThese findings suggest that microRNA expression patterns can differentiate several subsets of GISTs.19795448
Gastrointestinal Stromal TumorsEpigenetic AlterationsWe found 73 microRNAs that were significantly down-regulated in the GISTs with 14q loss; 38 of these microRNAs are encoded on 14q.19795448
Gastrointestinal Stromal Tumors, Intestines, SmallEpigenetic AlterationsWe also found many microRNAs that were down-regulated in small bowel and high-risk group GISTs.19795448
Intestines, Small, NeoplasmsEpigenetic AlterationsMost of the microRNAs down-regulated in the high-risk group and small bowel GISTs are known to be involved in tumor progression, specifically by stimulating mitogen-activated protein kinase (MAPK) and the cell cycle.19795448
Nephrotic SyndromeEpigenetic AlterationsHowever, to date, our knowledge about the alterations in histone modification in minimal change nephrotic syndrome (MCNS) is unknown.19797895
NeoplasmsEpigenetic AlterationsTo determine the hypermethylation status of the promoter regions of tumour suppressor genes in breast tissues from healthy women and identify the determinants of these epigenetic changes.19799643
CarcinogenesisEpigenetic AlterationsRecently, researchers have found that microRNAs play several important roles in carcinogenesis.19802518
Cutaneous Precancerous Condition, GastritisEpigenetic AlterationsGlobal genome hypomethylation has a fundamental role in early stages of tumorigenesis but little is known about this epigenetic event in gastric precancerous lesions such as gastritis.19806785
Stomach Carcinoma, CarcinogenesisEpigenetic AlterationsThis reduction probably continues in the next steps toward gastric cancer and may induce other epigenetic and/or genetic changes (such as MSI) that promote carcinogenesis.19806785
Neoplastic disease, Primary malignant neoplasmEpigenetic AlterationsOur findings support the idea that neoplasia may lead to a deregulation of miRNA expression in blood cells of cancer patients compared to blood cells of healthy individuals.19807914
Malignant NeoplasmsEpigenetic AlterationsFurthermore, we provide evidence that miRNA patterns can be used to detect human cancers from blood cells.19807914
Primary malignant neoplasmEpigenetic AlterationsDeregulated miRNAs are found in cancer cells and recently in blood cells of cancer patients.19807914
NeoplasmsEpigenetic AlterationsDue to their inherent stability miRNAs may offer themselves for blood based tumor diagnosis.19807914
Primary malignant neoplasmEpigenetic AlterationsHere we addressed the question whether there is a sufficient number of miRNAs deregulated in blood cells of cancer patients to be able to distinguish between cancer patients and controls.19807914
Carcinoma of lungEpigenetic AlterationsUsing t-test, we detected 27 miRNAs significantly deregulated in blood cells of lung cancer patients as compared to the controls.19807914
Glioblastoma MultiformeEpigenetic AlterationsMethylation of CpG islands in cancer-related genes may serve as an epigenetic biomarker for glioblastoma diagnosis and prognosis.19809523
Myelofibrosis, ThrombocytosisEpigenetic AlterationsMicroRNA expression profiling of megakaryocytes in primary myelofibrosis and essential thrombocythemia.19811223
PRB1 gene, Thrombocytosis, Primary MyelofibrosisEpigenetic AlterationsIn primary myelofibrosis (PMF) and essential thrombocythemia (ET) the megakaryocytic lineage characteristically shows aberrant proliferation and maturation in which the regulatory microRNA (miR) system might be involved.19811223
ClusterEpigenetic AlterationsCluster analysis revealed a tendency of disease-specific megakaryocytic microRNA expression profiles indicating that a complex shift of microRNA expression appears to be the underlying defect.19811223
PRB1 geneEpigenetic AlterationsIn conclusion, this is the first microRNA profiling of in situ-derived PMF, ET and normal megakaryocytes.19811223
PRB1 geneEpigenetic AlterationsLaser-microdissected PMF and ET megakaryocytes were analysed with real-time polymerase chain reaction (PCR) low density arrays comprising 365 microRNAs.19811223
Malignant neoplasm of liverEpigenetic AlterationsMicroRNA expression, survival, and response to interferon in liver cancer.19812400
Liver carcinomaEpigenetic AlterationsThe expression patterns of microRNAs in liver tissue differ between men and women with hepatocellular carcinoma.19812400
Liver carcinoma, NeoplasmsEpigenetic AlterationsConcordance of DNA methylation pattern in plasma and tumor DNA of Egyptian hepatocellular carcinoma patients.19818350
Communicable Diseases, Stomach CarcinomaEpigenetic AlterationsHelicobacter pylori (HP) infection potently induces aberrant DNA methylation in gastric mucosae, and its accumulation is associated with gastric cancer risk.19821005
SepticemiaEpigenetic AlterationsMicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis.19823581
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsAberrant DNA methylation is considered a major mechanism for silencing tumor suppressor genes in gastric cancer.19824040
Stomach CarcinomaEpigenetic AlterationsAdditional experiments showed that the promoter region of GRIK2 was hypermethylated in 3 of the 4 tested gastric cancer cell lines, and its expression was restored by treatment of cells with the DNA methylation inhibitor, 5-aza-dC.19824040
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsWe used CpG microarray and differential methylation hybridization strategies to identify potential tumor suppressor genes and recovered glutamate receptor, ionotropic, kainate 2 (GRIK2) as a novel epigenetic target in gastric cancer.19824040
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic silencing of E-cadherin via aberrant methylation has been investigated in various human tumors, whereas evidence for elucidating mechanism underlying reduction of E-cadherin mRNA remains unclear in non-small cell lung cancer (NSCLC).19842844
Carcinogenesis, Colorectal Cancer PathwayEpigenetic AlterationsAberrant DNA methylation affects carcinogenesis of colorectal cancer.19843671
Colorectal Cancer PathwayEpigenetic AlterationsGenetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer.19843671
Malignant neoplasm of urinary bladderEpigenetic AlterationsDistinct microRNA alterations characterize high- and low-grade bladder cancer.19843843
Primary malignant neoplasmEpigenetic AlterationsRecent evidence implicates a regulatory role for microRNA in cancer.19843843
CarcinogenesisEpigenetic AlterationsWe hypothesized that altered microRNA expression contributes to UCC carcinogenesis.19843843
NeoplasmsEpigenetic AlterationsIn UCC, microRNA alterations occur in a tumor phenotype-specific manner and can predict disease progression.19843843
Squamous cell carcinoma, SERPINB3 wt AlleleEpigenetic AlterationsHowever, to date the somatic epigenetic events that occur in cutaneous squamous cell carcinoma (SCC) tumorigenesis have not been well defined.19845668
FOXE1 geneEpigenetic AlterationsTo examine epigenetic abnormalities of FOXE1, a gene located on chromosome 9q22, a region frequently lost in SCC.19845668
Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetic gene silencing due to promoter methylation is observed in human cancers like acute myeloid leukemia (AML).19853913
NeoplasmsEpigenetic AlterationsWe observed mild to moderate DNA methylation levels in most tumors for ESR1 promoters A and B and PGR promoter B, and a few tumors showed mild methylation in PGR promoter A.19861523
Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetic regulation of the non-canonical Wnt pathway in acute myeloid leukemia.19874313
Neoplasms, Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe demonstrate that WNT5A, a putative tumor suppressor gene in AML, is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression and confers poor prognosis in patients with AML.19874313
Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA) opens up a new field for molecular diagnosis of cancer.19876917
Colorectal Cancer PathwayEpigenetic AlterationsPlasma microRNAs are promising novel biomarkers for early detection of colorectal cancer.19876917
Primary malignant neoplasmEpigenetic AlterationsHowever, the role of circulating miRNAs in plasma/serum in cancer diagnosis is not clear.19876917
AdenomaEpigenetic AlterationsMore importantly, these 2 miRNAs also could discriminate advanced adenomas from controls and yielded an AUC of 0.769 for miR-29a and 0.749 for miR-92a.19876917
NeoplasmsEpigenetic AlterationsDetection of these epigenetic changes in circulating DNA may not only enhance insight into the biological behavior of the primary tumor of an individual but may also provide valuable information regarding prognosis that can be readily monitored throughout the disease course.19879256
SchizophreniaEpigenetic AlterationsSchizophrenia is a multifactorial disorder characterized by the contribution of multiple susceptibility genes that may act in conjunction with epigenetic processes and environmental factors.19881467
CarcinogenesisEpigenetic AlterationsWarburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis.19881551
CarcinogenesisEpigenetic AlterationsSuch an important epigenetic link between glycolysis and carcinogenesis partly explains the Warburg effect.19881551
Thyroid DiseasesEpigenetic AlterationsAn interplay of genetic, epigenetic, and environmental factors contributes to thyroid disease.19882500
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsHematopoiesis-related microRNA expression in myelodysplastic syndromes.19883312
SF3B1 wt AlleleEpigenetic AlterationsWe assessed 25 mature miRNAs in total RNA from bone marrow (BM) and peripheral blood (PB) of 25 newly diagnosed patients with MDS and 12 controls.19883312
SF3B1 wt AlleleEpigenetic AlterationsTwelve miRNAs in BM and six in PB were differentially expressed between patients with MDS and controls.19883312
SF3B1 wt Allele, Leukemia, Myelocytic, AcuteEpigenetic AlterationsThis study adds further evidence to the role of miRNAs in the pathogenesis of MDS and their transformation into AML.19883312
Squamous cell carcinoma of the head and neckEpigenetic AlterationsSquamous cell carcinomas of head and neck (HNSCC) are a result of multiple genetic and epigenetic alterations.19885608
Head and Neck Carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic inactivation of tumor suppressor genes is an important event in head and neck carcinogenesis.19885608
Head and Neck CarcinomaEpigenetic AlterationsIn summary, frequent hyper-methylation of tumor-related genes in HNSCC was detected and this epigenetic silencing event may have an essential role in head and neck carcinogenesis.19885608
Colorectal CarcinomaEpigenetic AlterationsColorectal cancers (CRCs) may be classified according to underlying genetic and epigenetic changes including microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP).19885699
Malignant Neoplasms, Malignant Pleural MesotheliomaEpigenetic AlterationsMalignant pleural mesothelioma (MPM) is a fatal thoracic malignancy, the epigenetics of which are poorly defined.19887624
Malignant Pleural Mesothelioma, Adenocarcinoma of lung (disorder)Epigenetic AlterationsEpigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.19887624
NeoplasmsEpigenetic AlterationsOur findings show a characteristic epigenetic profile of MPM and uncover multiple distinct epigenetic abnormalities that lead to the silencing of tumor suppressor genes in MPM and could serve as diagnostic or prognostic targets.19887624
Ischemic strokeEpigenetic AlterationsWe therefore carried out microRNA (miRNA) profiling from peripheral blood to detect and identify characteristic patterns in ischaemic stroke.19888324
Cerebrovascular accidentEpigenetic AlterationsExpression profile of MicroRNAs in young stroke patients.19888324
Ischemic strokeEpigenetic AlterationsWe demonstrate that the peripheral blood miRNAs and their profiles can be developed as biomarkers in diagnosis and prognosis of cerebral ischaemic stroke.19888324
Cerebrovascular accidentEpigenetic AlterationsThe dysregulated miRNAs have been detectable even after several months from the onset of stroke in what is usually regarded as neurologically stable patients.19888324
NeoplasmsEpigenetic AlterationsIn order to estimate the overall susceptibility of MSs to MSI in MSI-H tumors, the observed MSI frequency of each MS was correlated with its length, interspecies sequence conservation level, and distance from some genetic elements (i.e., stop codon, polyA signal, and microRNA binding sites).19888451
SeizuresEpigenetic AlterationsThe predicted loss of a microRNA-accessible structure in mutant RB1CC1 RNA fits the hypothesis that 3UTR MSI involves in aberrant RB1CC1 posttranscriptional upregulation.19888451
Endometrial Serous AdenocarcinomaEpigenetic AlterationsA total of 120 miRNAs were differentially expressed in endometrial serous adenocarcinoma compared to normal endometria.19891660
Endometrial Serous AdenocarcinomaEpigenetic AlterationsThese findings suggest that the dysregulation of miRNAs is associated with the poor prognosis in endometrial serous adenocarcinoma patients.19891660
DNA Mismatch Repair Protein MSH2, human, mismatch repair protein 1, humanEpigenetic AlterationsThe aberrant DNA methylation patterns of four mismatch repair genes, hMLH1, hMSH2, hMSH3, and MGMT, were compared by bisulfite modification and methylation-specific PCR (MSP).19894224
Stomach CarcinomaEpigenetic AlterationsAberrant methylation of DNA mismatch repair genes in elderly patients with sporadic gastric carcinoma: A comparison with younger patients.19894224
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsBreast cancer is one of the most common cancer affecting women and the recent research is focused on identifying new genetic and epigenetic prognostic and predictive factors.19895170
Acute myocardial infarctionEpigenetic AlterationsCirculating microRNA-1 as a potential novel biomarker for acute myocardial infarction.19896465
Malignant NeoplasmsEpigenetic AlterationsCirculating miRNAs have been proposed as sensitive and informative biomarkers for multiple cancers diagnosis.19896465
NeoplasmsEpigenetic AlterationsFinally, the significance of DNA methylation in regulating gene promoters was shown by reinducing 4 methylated tumor suppressor genes (eg, VHL and ABI3) in IGHV unmutated samples using the methyl-inhibitor 5-aza-2-deoxycytidine.19897574
Primary malignant neoplasm, Chronic Lymphocytic LeukemiaEpigenetic AlterationsGlobal hypomethylation and regional hypermethylation are well-known epigenetic features of cancer; however, in chronic lymphocytic leukemia (CLL), studies on genome-wide epigenetic modifications are limited.19897574
Chronic Lymphocytic LeukemiaEpigenetic AlterationsTaken together, our data for the first time reveal differences in global methylation profiles between prognostic subsets of CLL, which may unfold epigenetic silencing mechanisms involved in CLL pathogenesis.19897574
Endometrial Carcinoma, Hyperplasia, Federation of Gynecology and Obstetrics, CarcinomaEpigenetic AlterationsDNA methylation of the APC gene increased from atypical hyperplasia (23.5%) to endometrial carcinoma, reaching its highest level of 77.4% in early stage cancer (FIGO I and II) and decreasing stepwise to 24.2% in advanced stage carcinomas (FIGO III and IV).19900189
Malignant Head and Neck NeoplasmEpigenetic AlterationsMicroRNA expression in head and neck cancer associates with alcohol consumption and survival.19901002
Malignant Head and Neck NeoplasmEpigenetic AlterationsTogether, these data suggest that alterations in miRNA expression are related to exposures causal in head and neck cancer and may be useful biomarkers of patient outcome.19901002
IGA GlomerulonephritisEpigenetic AlterationsThese miRNA species may be important in the pathogenesis and progression of IgA nephropathy.19901913
IGA GlomerulonephritisEpigenetic AlterationsIntrarenal expression of microRNAs in patients with IgA nephropathy.19901913
Malignant neoplasm of kidney, Glomerulosclerosis (disorder)Epigenetic AlterationsThe intrarenal expression of miRNAs was quantified and compared with that of 15 patients with noninflammatory glomerulosclerosis (GS group) and 20 patients with nephrectomy for kidney cancer as controls (CTL group).19901913
Renal sclerosis with hypertensionEpigenetic AlterationsThe results suggested that these miRNA species may play important roles in the pathogenesis of hypertensive nephrosclerosis.19910931
Renal sclerosis with hypertensionEpigenetic AlterationsIntrarenal expression of miRNAs in patients with hypertensive nephrosclerosis.19910931
Metastasis, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTumor invasiveness and metastasis in cancer progression is manifested by epigenetic abnormality.19914229
Liver carcinomaEpigenetic AlterationsAn insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3 untranslated region confers risk for hepatocellular carcinoma.19917630
Primary malignant neoplasmEpigenetic AlterationsGenetic polymorphisms in 3 untranslated regions (3 UTRs) targeted by miRNAs alter the strength of miRNA binding, with consequences on regulation of target genes thereby affecting the individuals cancer risk.19917630
Primary malignant neoplasmEpigenetic AlterationsWe have previously predicted polymorphisms falling in miRNA-binding regions of cancer genes.19917630
Renal Cell Carcinoma PathwayEpigenetic AlterationsDifferential expression of miRNA patterns in renal cell carcinoma and nontumorous tissues.19921256
Renal Cell CarcinomaEpigenetic AlterationsThe report supports that many miRNA expressions were altered in renal carcinoma, whose expression profiling may provide a useful clue for the pathophysiology research.19921256
Breast CarcinomaEpigenetic AlterationsWe analyzed four SNPs, one located in the pre-miRNA and the other three located in miRNA flanking regions, for a putative association with breast cancer risk.19921425
Breast CarcinomaEpigenetic AlterationsOur results suggest that promoter methylation could be promising epigenetic markers to be considered for breast cancer survival.19921426
Right armEpigenetic AlterationsmiRNA expression profile analysis highlighted that miR-223 is the only miRNA that is strikingly deregulated in peripheral T-lymphocytes from RA patients compared with healthy donors.19931339
Right armEpigenetic AlterationsIn summary, our data provide a first characterization of the miRNA expression profiles of peripheral T-lymphocytes of RA patients, identifying miR-223 as overexpressed in CD4(+) naive T-lymphocytes from these individuals.19931339
CarcinogenesisEpigenetic AlterationsAlterations in the RAS and RAF pathway relate to epigenetic and epigenomic aberrations, and are important in colorectal carcinogenesis.19934290
Prostate Cancer Pathway, Retinitis PigmentosaEpigenetic AlterationsIn combination with the Gleason score and pre-operation PSA level, the acetylation and methylation of histones H3 and H4 can predict the biochemical recurrence of the prostate cancer following RP.19935671
Colorectal Cancer PathwayEpigenetic AlterationsGermline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.19936946
Malignant neoplasm of stomachEpigenetic AlterationsGenetic and epigenetic characteristics of gastric cancers with JC virus T-antigen.19938198
CarcinogenesisEpigenetic AlterationsThe results suggest that JCV T-Ag is involved in gastric carcinogenesis through multiple mechanisms of genetic and epigenetic alterations.19938198
Weight decreasedEpigenetic AlterationsThese data show that both DNA methylation and gene expression are responsive to caloric restriction and provide new insights about the molecular pathways involved in body weight loss as well as methylation regulation during adulthood.19939982
Glioblastoma MultiformeEpigenetic AlterationsMicro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation.19941032
Glioblastoma Multiforme PathwayEpigenetic AlterationsOur data suggests that down-regulation of miRNA-128 may contribute to glioma and GBM, in part, by coordinately up-regulating ARP5 (ANGPTL6), Bmi-1 and E2F-3a, resulting in the proliferation of undifferentiated GBM cells.19941032
Chronic Lymphocytic LeukemiaEpigenetic AlterationsZAP-70 intron1 DNA methylation status: determination by pyrosequencing in B chronic lymphocytic leukemia.19944462
Stomach CarcinomaEpigenetic AlterationsSurvival prediction of gastric cancer by a seven-microRNA signature.19951901
Primary malignant neoplasmEpigenetic AlterationsSeveral microarray studies have reported microRNA (miRNA) expression signatures that classify cancer patients into different prognostic groups.19951901
Stomach CarcinomaEpigenetic AlterationsIn this study, we developed a seven-miRNA signature that is closely associated with survival of patients with gastric cancer.19951901
Stomach CarcinomaEpigenetic AlterationsMiRNA expression profile was analysed by real-time RT-PCR in 100 gastric cancer patients, which were randomly assigned to either the training set or the testing set.19951901
Stomach CarcinomaEpigenetic AlterationsWe have identified a seven-miRNA signature (miR-10b, miR-21, miR-223, miR-338, let-7a, miR-30a-5p, miR-126) for overall survival (p=0.0009) and relapse-free survival (p=0.0005) of gastric cancer patients.19951901
Stomach CarcinomaEpigenetic AlterationsOur seven-miRNA signature is closely associated with relapse-free and overall survival among patients with gastric cancer.19951901
Colorectal Cancer PathwayEpigenetic AlterationsEarly life exposure to famine and colorectal cancer risk: a role for epigenetic mechanisms.19956740
Clinical CoordinatorEpigenetic AlterationsThis is the first study indicating that exposure to a severe, transient environmental condition during adolescence and young adulthood may result in persistent epigenetic changes that later influence CRC development.19956740
Stomach CarcinomaEpigenetic AlterationsEpigenetic silencing of RELN in gastric cancer.19956836
Carcinogenesis, NeoplasmsEpigenetic AlterationsEpigenetic alteration of tumor-related genes through changes of DNA methylation is a hallmark for carcinogenesis and aberrant DNA methylation modulates the activity of tumor suppressor genes, imprinted genes and repetitive elements.19956846
Liver carcinoma, NeoplasmsEpigenetic AlterationsHigh expression of microRNA-15b predicts a low risk of tumor recurrence following curative resection of hepatocellular carcinoma.19956871
Carcinogenesis, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNA) have recently been implicated in carcinogenesis and tumor progression.19956871
Hollings Cancer CenterEpigenetic AlterationsWe attempted to identify the miRNAs associated with HCC recurrence.19956871
Hollings Cancer CenterEpigenetic AlterationsOut of 449 miRNAs assayed, we identified seven miRNAs associated with HCC recurrence.19956871
Anaplastic large B-cell lymphoma, B-Cell Lymphomas, NeoplasmsEpigenetic AlterationsThese results indicate that global histone modification profiles specific to non-neoplastic germinal center B lymphocytes and mantle zone B lymphocytes are well conserved in corresponding neoplastic lymphoma cells, and suggest that they will be indicative of tumor cell type at least in B cell lymphoma.19960376
Breast Cancer CellEpigenetic AlterationsMicroRNA (miRNA) deregulation is a hallmark of human cancer.19960504
DICER1 protein, humanEpigenetic AlterationsDicer is a key enzyme in the miRNA processing pathway that is essential for the production of mature miRNAs from their precursors.19960504
DICER1 protein, humanEpigenetic AlterationsOur data suggest a common mechanism for miRNAs changes by alterations in the basic machinery controlling miRNA biogenesis, of which Dicer is a central enzyme.19960504
Ovarian Carcinoma, NeoplasmsEpigenetic AlterationsThese alterations of miRNA processing are of prognostic value and may play a role in the molecular pathogenesis of ovarian carcinoma and, possibly, other tumours.19960504
Primary malignant neoplasmEpigenetic AlterationsDNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer.19966864
Aggressive behaviorEpigenetic AlterationsGene networks and microRNAs implicated in aggressive prostate cancer.19996289
Prostate Cancer PathwayEpigenetic AlterationsFurther characterization of cell cycle-related genes (particularly, the hub genes) and miRNAs that regulate these hub genes could facilitate identification of candidate genes responsible for the aggressive phenotype and lead to a better understanding of prostate cancer etiology and progression.19996289
CarcinogenesisEpigenetic AlterationsDNA methylation is a common event in gastric carcinogenesis.20001710
MYELODYSPLASTIC SYNDROME, NeoplasmsEpigenetic AlterationsEpigenetic inactivation of tumour suppressor gene KLF11 in myelodysplastic syndromes*.20002157
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsThe identification of aberrantly hypermethylated genes may lead to the development of new diagnostic markers and the identification of novel targets of epigenetic therapy in myelodysplastic syndromes (MDS).20002157
SF3B1 wt AlleleEpigenetic AlterationsIn conclusion, epigenetic inactivation and subsequent transcriptional repression of the KLF11 gene is quite frequent in MDS.20002157
Adult T-Cell Lymphoma/Leukemia, TCL4 geneEpigenetic AlterationsHowever, little is known about the association of epigenetic abnormalities with multistep tumorigenic events in adult T cell leukemia/lymphoma (ATLL).20019193
Adult T-Cell Lymphoma/LeukemiaEpigenetic AlterationsTo determine whether epigenetic abnormalities induce the progression of ATLL, we analyzed the methylation profiles of the SHP1, p15, p16, p73, HCAD, DAPK, hMLH-1, and MGMT genes by methylation specific PCR assay in 65 cases with ATLL patients.20019193
NeoplasmsEpigenetic AlterationsAnalyses of microRNA expression profiles have shown that many microRNAs are expressed aberrantly and correlate with tumorigenesis, progression, and prognosis of various haematological and solid tumours.20022810
Metastasis, Primary malignant neoplasmEpigenetic AlterationsMicroRNA expression patterns were compared between non-tumour mucosa and cancer samples, graded by diffuse and intestinal histological types and by progression-related factors (eg, depth of invasion, metastasis, and stage).20022810
Stomach Carcinoma, Intestinal CancerEpigenetic AlterationsThe two histological subtypes of gastric cancer showed different microRNA signatures: eight microRNAs were upregulated in diffuse-type and four in intestinal-type cancer.20022810
Malignant neoplasm of stomachEpigenetic AlterationsMicroRNAs are expressed differentially in gastric cancers, and histological subtypes are characterised by specific microRNA signatures.20022810
Stomach CarcinomaEpigenetic AlterationsUnique microRNAs are associated with progression and prognosis of gastric cancer.20022810
Childhood Leukemia, Primary malignant neoplasm, Leukemia, Myelocytic, AcuteEpigenetic AlterationsFavorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study.20026798
Cytogenetically normal acute myeloid leukemia, Leukemia, Myelocytic, AcuteEpigenetic AlterationsTo analyze the prognostic significance of NPM1 mutations, and the associated gene- and microRNA-expression signatures in older patients with de novo, cytogenetically normal acute myeloid leukemia (CN-AML) treated with intensive chemotherapy.20026798
Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsGene- and microRNA-expression profiles associated with NPM1 mutations were similar across older patient age groups and similar to those in younger (< 60 years) patients with CN-AML.20026798
Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsThe gene- and microRNA-expression profiles suggest that NPM1 mutations constitute a marker defining a biologically homogeneous entity in CN-AML that might be treated with specific and/or targeted therapies across age groups.20026798
Metastasis, Primary malignant neoplasmEpigenetic AlterationsAltered microRNA (miRNA) expression has been associated with both cancer progression and metastasis.20028561
Non-Small Cell Lung CarcinomaEpigenetic AlterationsEvaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after surgical resection.20028859
Non-Small Cell Lung Carcinoma, Primary malignant neoplasmEpigenetic AlterationsWe surveyed expression profiles of microRNA (miRNA) in stage I NSCLC to identify patterns that might predict recurrence after surgical resection of this common deadly cancer.20028859
Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur findings reinforce efforts to profile miRNA expression patterns for better prognostication of stage I NSCLC.20028859
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsMicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction.20029200
Myocardium, Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsIn recent studies, three miRNAs have been described as muscle or cardiac specific: miR-1, miR-133, and miR-208, being involved in heart development and disease; but there are limited data on their role in human myocardial infarction (MI).20029200
Papillary thyroid carcinoma, Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear FeaturesEpigenetic AlterationsDifferential miRNA expression profiles in variants of papillary thyroid carcinoma and encapsulated follicular thyroid tumours.20029416
MethylnitronitrosoguanidineEpigenetic AlterationsThe mean values of the expression pattern of all miRNAS in PTCs show a statistically significant difference from those in MNG and FA with fold changes up to 90 for miRNA 146b, P<0.001.20029416
MethylnitronitrosoguanidineEpigenetic AlterationsThe PTC-FVs differ significantly from FA in all five miRNAS, from MNG in three and from WDT-UMP in one miRNA with fold changes between 1.7 and 21.2, but failed to be of diagnostic value regarding individual cases with substantial overlaps.20029416
Acute Coronary SyndromeEpigenetic AlterationsT cell DNA methylation levels decline with age, activating genes such as KIR and TNFSF7 (CD70), implicated in lupus-like autoimmunity and acute coronary syndromes.20035856
S-AdenosylhomocysteineEpigenetic AlterationsMaintenance of DNA methylation depends on DNA methyltransferase 1 (Dnmt1) and intracellular S-adenosylmethionine (SAM) levels, and is inhibited by S-adenosylhomocysteine (SAH).20035856
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsDNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes.20038729
SF3B1 wt AlleleEpigenetic AlterationsDNA methylation predicts overall and progression-free survival in MDS.20038729
SF3B1 wt AlleleEpigenetic AlterationsEpigenetic therapy using decitabine, a DNA hypomethylating agent, is clinically effective for the treatment of MDS.20038729
InflammationEpigenetic AlterationsWe hypothesized that chronic inflammation is associated with altered DNA methylation levels within the PTGS2 promoter, with effects on COX-2 mRNA expression.20042743
InflammationEpigenetic AlterationsThese findings suggest that the chronic persistence of the biofilm and inflammation may be associated with epigenetic changes in local tissues at the biofilm-gingival interface.20042743
Primary malignant neoplasmEpigenetic AlterationsThe polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis.20044760
Helicobacter-associated gastritisEpigenetic AlterationsThe gastric epithelium genome undergoes extensive epigenetic alterations during Helicobacter pylori-induced gastritis.20044995
Infection caused by Helicobacter pylori, gastritis h pyloriEpigenetic AlterationsWe characterized expression of MGMT and its epigenetic regulation via CpG methylation in gastric tissue from patients with H pylori gastritis and investigated the effects of H pylori infection eradication on MGMT expression.20044995
Acute leukemiaEpigenetic AlterationsDeficient histone acetylation in acute leukemia and the correction by an isothiocyanate.20051681
Leukemia, Myelocytic, AcuteEpigenetic AlterationsHistone acetylation was up-regulated in the presence of PHI, revealing an excess of deacetylation activity in AML.20051681
Acute leukemiaEpigenetic AlterationsDeficient histone acetylation may represent an aberration at the epigenetic level in acute leukemia.20051681
Acute leukemiaEpigenetic AlterationsAcetylation of histones H3 and H4 was virtually undetectable or significantly lower in acute leukemia.20051681
Childhood LeukemiaEpigenetic AlterationsPHI might represent a target for correcting deficient acetylation, and potential epigenetic regulators for preventing the progression of leukemia.20051681
Malignant tumor of colonEpigenetic AlterationsHormone therapy, DNA methylation and colon cancer.20064828
ovarian neoplasmEpigenetic AlterationsOur previous study showed that ADAM19, a SMAD4 target gene, is downregulated through epigenetic mechanisms in ovarian cancer with aberrant TGF-beta/SMAD4 signaling.20065949
ovarian neoplasmEpigenetic AlterationsFBXO32 methylation was observed in ovarian cancer cell lines displaying constitutive TGF-beta/SMAD4 signaling, and epigenetic drug treatment restored FBXO32 expression in ovarian cancer cell lines regardless of FBXO32 methylation status, suggesting that epigenetic regulation of this gene in ovarian cancer may be a common event.20065949
Carcinoma of lungEpigenetic AlterationsMicroRNA expression differentiates histology and predicts survival of lung cancer.20068076
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsMicroRNA microarray expression profiling in human myocardial infarction.20075508
Primary malignant neoplasmEpigenetic AlterationsIn addition, histone acetylation levels in the promoter regions of CTA genes were high in cancer stem cells and low in differentiated cells, while DNA methylation analysis of the promoter regions revealed hypomethylation in cancer stem cells.20082319
NeoplasmsEpigenetic AlterationsThis epigenetic difference between cells leads to heterogeneous expression of CTA genes in the tumor mass, which consists of cells at various levels of differentiation.20082319
Mantle cell lymphomaEpigenetic AlterationsmicroRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.20086245
Medial collateral ligamentEpigenetic AlterationsHere, we performed miRNA expression profile in 30 patients with MCL using a platform containing 515 human miRNAs.20086245
Malignant NeoplasmsEpigenetic AlterationsThus, our findings provide not only miRNA expression signature but also a novel prognostic marker and pathogenetic factor for this malignancy.20086245
Medial collateral ligamentEpigenetic AlterationsEighteen miRNAs were down-regulated and 21 were up-regulated in MCL compared with normal B lymphocytes.20086245
Endometrial adenocarcinoma, NeoplasmsEpigenetic AlterationsIs global DNA methylation in sporadic uterine adenocarcinomas in women a result of histological and clinical tumor advancement?20088395
Endometrial adenocarcinomaEpigenetic AlterationsTo find out the relationship, if any between the extent of the overall genomic DNA methylation, and clinical and pathological features of the sporadic endometrial adenocarcinomas in women.20088395
Primary malignant neoplasmEpigenetic AlterationsMean total cancer DNA methylation (3.48+/-0.46%) was significantly higher than that of the normal proliferative endometrium (2.94+/-0.4%, p=0.003) and lower than that of the secretory endometrium DNAs (3.75+/-0.47%, p=0.03).20088395
NeoplasmsEpigenetic AlterationsLower levels of DNA methylation seemed to be associated with diminished tumor invasiveness.20088395
Malignant neoplasm of endometriumEpigenetic AlterationsOur results suggest that alterations in overall DNA methylation seem to be a result of neoplastic transformation and could therefore be used as a prognostic molecular marker of endometrial cancer.20088395
Clinical Coordinator, NeoplasmsEpigenetic AlterationsTo assess the effect of methylation in tumor multiplicity in sporadic CRC, hypermethylation of key tumor suppressor genes was evaluated in patients with both multiple and solitary tumors, as a proof-of-concept of an underlying epigenetic defect.20098741
Clinical CoordinatorEpigenetic AlterationsThis underlying epigenetic defect may have noteworthy implications in the prevention of patients with sporadic CRC.20098741
Thrombocytopenic purpura, Autoimmune DiseasesEpigenetic AlterationsEpigenetics might contribute to autoimmune diseases including immune thrombocytopenic purpura (ITP).20100009
Mismatch Repair Deficiency, Hereditary Nonpolyposis Colorectal CancerEpigenetic AlterationsAberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.20102720
Malignant Neoplasms, Childhood LeukemiaEpigenetic AlterationsMicroRNAs (miRNAs) are small ( approximately 22 nucleotide) non-coding RNAs whose altered expression has been associated with various types of cancers, including leukemia.20110180
Acute leukemiaEpigenetic AlterationsMicroRNAs expression signatures are associated with lineage and survival in acute leukemias.20110180
MICROPHTHALMIA, SYNDROMIC 7Epigenetic AlterationsWe show that 16 miRNAs were differentially expressed between AMLs and ALLs.20110180
cervical cancerEpigenetic AlterationsHowever, dietary or pharmaceutical agents that can inhibit these epigenetic events may prevent or delay the development of cervical cancer.20112504
CarcinogenesisEpigenetic AlterationsAberrant methylation of TFPI2 promoter CpG island occurred not only in GC cells but also in primary GC tissues at a high frequency, suggesting that epigenetic silencing of TFPI2 may contribute to gastric carcinogenesis.20113832
Non-Small Cell Lung CarcinomaEpigenetic AlterationsEpigenetic inactivation of retinoid X receptor genes in non-small cell lung cancer and the relationship with clinicopathologic features.20113835
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsAberrant methylation of DNA-damage-inducible transcript 3 promoter is a common event in patients with myelodysplastic syndrome.20116099
SF3B1 wt Allele, Neoplasms, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsThe epigenetic changes of tumor suppressor genes are now recognized as an alternative mechanism contributing to the development of myelodysplastic syndrome (MDS).20116099
Hematologic NeoplasmsEpigenetic AlterationsEpigenetic inactivation of the miR-34a in hematological malignancies.20118199
Infection caused by Helicobacter pyloriEpigenetic AlterationsInflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells.20124475
Communicable Diseases, Stomach Carcinoma, Helicobacter pyloriEpigenetic AlterationsAltered patterns of DNA methylation associated with Helicobacter pylori (HP) infection of gastric epithelial cells are thought to contribute to gastric cancer risk.20124475
Communicable Diseases, Stomach CarcinomaEpigenetic AlterationsIn this study, we sought to clarify mechanisms in a gerbil model of gastric cancer where we showed that HP infection is causally involved in induction of aberrant DNA methylation.20124475
Communicable DiseasesEpigenetic AlterationsOur findings argue that DNA methylation alterations that occur in gastric mucosae after HP infection are composed of transient components and permanent components, and that it is the infection-associated inflammatory response, rather than HP itself, which is responsible for inducing the altered DNA methylation.20124475
Glioblastoma Multiforme PathwayEpigenetic AlterationsEpigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells.20124482
Degenerative polyarthritisEpigenetic AlterationsMicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes.20131257
DiseaseEpigenetic AlterationsAberrant posttranscriptional regulation of matrix metalloproteinases (MMPs) by microRNA has emerged as an important factor in human diseases.20131257
Degenerative polyarthritisEpigenetic AlterationsIn IL-1beta-stimulated OA chondrocytes, 42 microRNA were down-regulated, 2 microRNA were up-regulated, and the expression of 308 microRNA remained unchanged.20131257
CarcinogenesisEpigenetic AlterationsAberrant DNA methylation is involved in colon carcinogenesis.20131317
Colorectal Carcinoma, NeoplasmsEpigenetic AlterationsAlthough the CpG island methylator phenotype (CIMP) is defined as a subset of colorectal cancers (CRCs) with remarkably high levels of DNA methylation, it is not known whether epigenetic processes are also involved in CIMP-negative tumors.20131317
Glioblastoma Multiforme PathwayEpigenetic AlterationsSurprisingly, NCX2 could be activated by addition of the DNA methylation inhibitor 5-aza-2-deoxycytidine to glioma cell lines in which NCX2 was completely silent.20132488
GliomaEpigenetic AlterationsMolecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas.20132488
Breast CarcinomaEpigenetic AlterationsCirculating microRNAs as novel minimally invasive biomarkers for breast cancer.20134314
Breast Carcinoma, Mammary NeoplasmsEpigenetic AlterationsWe report that cancer-specific miRNAs were detected and significantly altered in the circulation of breast cancer patients, and that increased systemic miR-195 levels in breast cancer patients were reflected in breast tumors.20134314
Breast CarcinomaEpigenetic AlterationsThese findings suggest that systemic miRNAs have potential use as novel breast cancer biomarkers and may prove useful in clinical management during the perioperative period.20134314
Colorectal Cancer PathwayEpigenetic AlterationsWhile these data confirm the detection rate of SEPT9 as a biomarker for colorectal cancer, they also show that methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9.20140221
Primary malignant neoplasmEpigenetic AlterationsAbberant DNA methylation at CpG dinucleotides represents a common mechanism of transcriptional silencing in cancer.20144234
Oropharyngeal Route of Drug Administration, Hypopharyngeal CancerEpigenetic AlterationsNo major difference was detected in miRNA profiles among laryngeal, oropharyngeal, or hypopharyngeal cancers.20145181
Squamous cell carcinoma of the head and neck, Molecular AbnormalityEpigenetic AlterationsFurther detailed examinations of miRNAs will provide opportunities to dissect the complex molecular abnormalities driving HNSCC progression.20145181
GliomaEpigenetic AlterationsSerum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades.20150384
Refractory Cytopenia of Childhood, Renal Cell Carcinoma PathwayEpigenetic AlterationsWe used high-density gene expression microarrays in a functional epigenetic study of 11 renal cell carcinoma (RCC) cell lines.20154727
Carcinoma of lungEpigenetic AlterationsEpigenetic inactivation of the thyroid hormone receptor beta1 gene at 3p24.2 in lung cancer.20155399
Carcinoma of lungEpigenetic AlterationsThis is the first study to demonstrate epigenetic inactivation of TRbeta1 through aberrant methylation in lung cancer, while TRbeta1 mutations are not common in lung cancer.20155399
MesotheliomaEpigenetic AlterationsMoreover, major epigenetic regulation of mesothelioma is mediated by hsa-miR-29c* and was shown through downregulation of DNA methyltransferases as well as upregulation of demethylating genes.20160038
Malignant neoplasm of urinary bladderEpigenetic AlterationsWe have recently identified down-regulated microRNAs including miR-145 and miR-133a in bladder cancer (BC).20160723
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsMicroRNA miR-1 is up-regulated in remote myocardium in patients with myocardial infarction.20163779
Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA) plays a critical role in tumorigenesis, but it is still unknown if variants in miRNA genes lead to predisposition to cancer.20167074
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsConsidering the fact that miRNA regulates a number of tumor suppressor genes (TSGs) and oncogenes, genetic variations in miRNA genes could affect the levels of expression of TSGs or oncogenes and, thereby, cancer risk.20167074
ovarian neoplasmEpigenetic AlterationsTo test this hypothesis in familial ovarian cancer, we screened for genetic variants in thirty selected miRNA genes, which are predicted to regulate key ovarian cancer genes and are reported to be misexpressed in ovarian tumor tissues, in eighty-three patients with familial ovarian cancer.20167074
Glioblastoma MultiformeEpigenetic AlterationsEpigenetic silencing of the MGMT gene by promoter methylation is associated with loss of MGMT expression, diminished DNA-repair activity and longer overall survival in patients with glioblastoma who, in addition to radiotherapy, received alkylating chemotherapy with carmustine or temozolomide.20167086
Myeloid Leukemia, ChronicEpigenetic AlterationsTo address this question, we compared the level of their expression with the DNA methylation and histone acetylation status of 5 sequences of both genes in leukemic cell lines and primitive (lin-CD34+) leukemic cells from chronic phase CML patients.20175919
Myeloid Leukemia, ChronicEpigenetic AlterationsIn contrast, we found a strong relation between CD7 expression and transcription-permissive chromatin modifications, both at the level of DNA methylation and histone acetylation with evidence of hypomethylation of the CD7 promoter region in the lin-CD34+ cells from CML patients with high CD7 expression.20175919
Myeloid Leukemia, ChronicEpigenetic AlterationsExpression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia.20175919
Myeloid Leukemia, ChronicEpigenetic AlterationsThese findings indicate a link between epigenetic modifications and CD7 expression in primitive CML cells.20175919
Colorectal Cancer PathwayEpigenetic AlterationsGenetic modulation of the Let-7 microRNA binding to KRAS 3-untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab-irinotecan.20177422
NeoplasmsEpigenetic AlterationsThere is increasing evidence that the Let-7 microRNA (miRNA) exerts an effect as a tumor suppressor by targeting the KRAS mRNA.20177422
CarcinogenesisEpigenetic AlterationsEpigenetic alterations including changes to cellular DNA methylation levels contribute to carcinogenesis and may serve as powerful biomarkers of the disease.20179218
Malignant neoplasm of urinary bladderEpigenetic AlterationsThis investigation sought to determine whether hypomethylation at the long interspersed nuclear elements (LINE1), reflective of the level of global DNA methylation, in peripheral blood-derived DNA is associated with increased risk of bladder cancer.20179218
Carcinoma, Ovarian EpithelialEpigenetic AlterationsDNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines.20179752
ovarian neoplasm, NeoplasmsEpigenetic AlterationsThis study applied recently developed methods for high-throughput DNA methylation profiling to characterize ovarian cancer cell lines and tumors, including representatives of three major histologies.20179752
Epithelial tumor of ovary, ovarian neoplasmEpigenetic AlterationsWe obtained DNA methylation profiles of 1,505 CpG sites (808 genes) in 27 primary epithelial ovarian tumors and 15 ovarian cancer cell lines.20179752
ovarian neoplasmEpigenetic AlterationsWe found that the DNA methylation profiles of ovarian cancer cell lines were markedly different from those of primary ovarian tumors.20179752
ovarian neoplasmEpigenetic AlterationsAggregate DNA methylation levels of the assayed CpG sites tended to be higher in ovarian cancer cell lines relative to ovarian tumors.20179752
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsIn conclusion, KLK10 acts as a functional tumor suppressor gene in NSCLC, epigenetic inactivation of KLK10 is a common event contributing to NSCLC pathogenesis and may be used as a potential biomarker.20180809
Primary malignant neoplasmEpigenetic AlterationsPrevious studies have suggested that microRNAs (miRNAs) may play important roles in tumorigenesis, but little is known about the functions of most miRNAs in cancer development.20180843
Malignant NeoplasmsEpigenetic AlterationsIt involves a very frequent epigenetic event that is found in many human cancers.20186007
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs are short noncoding RNAs that regulate multiple mRNAs and are frequently dysregulated in cancer.20187102
Malignant neoplasm of stomachEpigenetic AlterationsDNA methylation patterns of ulcer-healing genes associated with the normal gastric mucosa of gastric cancers.20191040
Gastric mucosaEpigenetic AlterationsRecent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation.20191040
Adenocarcinoma, Non-Small Cell Lung CarcinomaEpigenetic AlterationsMost likely, genetic and epigenetic mechanisms might be responsible for transcriptional inactivation of RBSP3 in non-small cell lung cancers as promoter methylation of RBSP3 according to NotI microarrays data was detected in 80% of squamous cell and in 38% of adenocarcinomas.20193080
NeoplasmsEpigenetic AlterationsBoth genetic and epigenetic mechanisms contribute to down-regulation of these three genes representing two tumor suppressor clusters in 3p21.3.20193080
Alzheimers Disease", Neurodegenerative DisordersEpigenetic AlterationsAberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3.20202123
Epidermal cellsEpigenetic AlterationsExpression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer.20210522
Malignant NeoplasmsEpigenetic AlterationsDysregulation of microRNA (miRNA) metabolism has been observed in a variety of human cancers.20210522
Epidermal cellsEpigenetic AlterationsTherefore, we favor the hypothesis that miRNAs are involved in the carcinogenesis of epithelial skin cancer.20210522
Prostate Cancer PathwayEpigenetic AlterationsDNA methylation of HOXD3 as a marker of prostate cancer progression.20212450
Primary malignant neoplasmEpigenetic AlterationsDNA methylation in gene promoters causes gene silencing and is a common event in cancer development and progression.20212450
Cardiovascular DiseasesEpigenetic AlterationsmiRNAs (microRNAs) participate in many diseases including cardiovascular disease.20218970
AstrocytomaEpigenetic AlterationsOur results suggest a great potential for the use of miRNA profiling as a powerful diagnostic and prognostic marker in defining the signature of astrocytomas and in predicting the post-surgical outcome.20219352
Malignant Neoplasms, DiseaseEpigenetic AlterationsThe aberrant expression of microRNAs (miRNAs) is associated with a variety of diseases including cancers.20219352
AstrocytomaEpigenetic AlterationsWe screened the expression profile of 200 miRNAs in a training sample set consisting of 84 astrocytoma samples and 20 normal adjacent tissue (NAT) samples using the method of stem-loop quantitative RT-PCR.20219352
AstrocytomaEpigenetic AlterationsThe significantly altered miRNAs were validated in another independent sample set consisting of 40 astrocytoma samples and 40 NAT samples.20219352
AstrocytomaEpigenetic AlterationsAfter a two-phase selection and validation process, seven miRNAs were found to have a significantly different expression profile in astrocytoma samples upon comparison to the NAT samples.20219352
Primary malignant neoplasmEpigenetic AlterationsAge-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.20219944
S100A4 protein, humanEpigenetic AlterationsThese findings shed substantial novel insights into the epigenetic effects of aging and support the view that age may predispose to malignant transformation by irreversibly stabilizing stem cell features.20219944
NeoplasmsEpigenetic AlterationsAnalyzing DNA methylation of 25 CpG sites within 960 bp around the transcription initiation site of the SERPINE1 gene by bisulfite sequencing, we did the surprising observation that both tumors and tumor-adjacent normal tissue had a significant level of methylation, whereas there was very little methylation in tissue from healthy volunteers, suggesting that tumor-adjacent normal tissue already contains transformation-associated epigenetic changes.20222049
Squamous cell carcinomaEpigenetic AlterationsEpigenetic alterations of the SERPINE1 gene in oral squamous cell carcinomas and normal oral mucosa.20222049
Carcinogenesis, Infection caused by Helicobacter pyloriEpigenetic AlterationsEpigenetic inactivation of GATA-4 (and GATA-5) by methylation of CpG islands is an early frequent event during gastric carcinogenesis and is significantly correlated with H. pylori infection.20222162
Malignant Neoplasms, DiseaseEpigenetic AlterationsMicroRNAs (miRNAs) are a class of small non-coding RNAs regulating gene expression that play roles in the pathogenesis of human diseases, including malignancy.20223231
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC).20223231
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsmiR-21, a commonly overexpressed miRNA in very diverse types of malignancies, may affect tumor progression through targeting tumor suppressor genes.20223231
NeoplasmsEpigenetic AlterationsMolecular detection of B-cell neoplasms by specific DNA methylation biomarkers.20224725
Lymphoid leukemia, NeoplasmsEpigenetic AlterationsA novel, easy to perform PCR-based method employing specific DNA methylation biomarkers to detect B-cell neoplasms in a variety of B-cell lines and B lymphoblastic leukemia (B-ALL) patient specimens has been developed.20224725
Breast Carcinoma, SCGB3A1 wt AlleleEpigenetic AlterationsA quantitative methylation-specific PCR assay was used to analyze the DNA methylation status of 6 genes (DAPK, TWIST, HIN-1, RASSF1A, RARbeta2 and APC) in 9 normal breast tissue samples from unaffected women and in 56 paired cancerous and normal tissue samples from breast cancer patients.20226036
Mammary NeoplasmsEpigenetic AlterationsThese data indicated that LOH and aberrant DNA methylation might be the possible reasons of the decreased expression of beclin 1 in the breast tumors.20230646
Mammary NeoplasmsEpigenetic AlterationsGenetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors.20230646
Malignant neoplasm of mouthEpigenetic AlterationsIncrease of microRNA miR-31 level in plasma could be a potential marker of oral cancer.20233326
Squamous cell carcinoma of the head and neckEpigenetic AlterationsGenetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted.20300172
Squamous cell carcinoma of the head and neck, NeoplasmsEpigenetic AlterationsSolid tumors, including head and neck squamous cell carcinomas (HNSCC), arise as a result of genetic and epigenetic alterations in a sustained stress environment.20300172
NeoplasmsEpigenetic AlterationsWe have extended a prior analysis of 1,413 cancer-associated loci for epigenetic changes in HNSCC by integrating DNA copy number alterations, measured at 500,000 polymorphic loci, in a case series of 19 primary HNSCC tumors.20300172
Primary malignant neoplasm, Loss of HeterozygosityEpigenetic AlterationsThis work, using a novel and robust statistical approach demonstrates that, although a "second hit" mechanism is not likely the predominant mode of action for epigenetic dysregulation in cancer, the patterns of methylation events are associated with the patterns of allele loss.20300172
Cardiovascular DiseasesEpigenetic AlterationsDNA methylation as a biomarker for cardiovascular disease risk.20300621
ObesityEpigenetic AlterationsOur findings indicate that elevated, not decreased, PBL DNA methylation is positively associated with prevalence of CVD/predisposing conditions and obesity in Singapore Chinese.20300621
Neoplasm MetastasisEpigenetic AlterationsMicroRNAs play key roles in tumor metastasis.20300657
Barrett EsophagusEpigenetic AlterationsMicroRNA profiling of Barretts oesophagus and oesophageal adenocarcinoma.20301167
Primary malignant neoplasmEpigenetic AlterationsThe aberrant expression of microRNAs (miRNAs) is involved in the development of cancer.20301167
melanoma, InflammationEpigenetic AlterationsOur findings, although preliminary, support the notion that the differential biology of melanoma at the extremes of age is driven, in part, by deregulation of microRNA expression and by fine tuning of miRs that are already known to regulate cell cycle, inflammation, Epithelial-Mesenchymal Transition (EMT)/stroma and more specifically genes known to be altered in melanoma.20302635
ArteriosclerosisEpigenetic AlterationsLower blood DNA methylation has been associated with atherosclerosis and high cardiovascular risk.20305373
Cardiovascular DiseasesEpigenetic AlterationsOur data provide new insights into epigenetic events that may accompany the development of cardiovascular disease.20305373
Liver carcinomaEpigenetic AlterationsHepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors.20305825
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsOur study shows that HCC tumors exhibit specific DNA methylation signatures associated with major risk factors and tumor progression stage, with potential clinical applications in diagnosis and prognosis.20305825
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsHepatocellular carcinoma (HCC) is characterized by late detection and fast progression, and it is believed that epigenetic disruption may be the cause of its molecular and clinicopathological heterogeneity.20305825
Carcinogenesis, Esophageal carcinomaEpigenetic AlterationsAltered microRNA (miRNA) expression has been found to promote carcinogenesis, but little is known about the role of miRNAs in esophageal cancer.20309880
Esophageal carcinomaEpigenetic AlterationsPrognostic significance of differentially expressed miRNAs in esophageal cancer.20309880
Esophageal carcinomaEpigenetic AlterationsIn this study, we selected 10 miRNAs and analyzed their expression in 10 esophageal cancer cell lines and 158 tissue specimens using Northern blotting and in situ hybridization, respectively.20309880
NeoplasmsEpigenetic AlterationsGenetic and epigenetic data indicate oncogenic or tumor suppressor function of these pleiotropic regulators.20331864
Breast CarcinomaEpigenetic AlterationsHowever, nothing is known so far about microRNA expression in male breast cancer, accounting for approximately 1% of all breast cancer cases.20331864
Breast CarcinomaEpigenetic AlterationsNot all of them are shared with breast cancer biopsies from female patients indicating male breast cancer specific alterations of microRNA expression.20331864
Breast CarcinomaEpigenetic AlterationsIdentification of differentially expressed microRNAs in human male breast cancer.20331864
Breast CarcinomaEpigenetic AlterationsMale breast cancer displays several differentially expressed microRNAs.20331864
Carcinoma, Ovarian EpithelialEpigenetic Alterations[Expression of microRNA-21 in ovarian epithelial carcinoma and its clinical significance].20335152
Mammary NeoplasmsEpigenetic AlterationsDNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.20338046
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsBreast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics.20338046
Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic inactivation of CADM1/TSLC1 gene is a frequent alteration in development of colorectal cancer and can be a potential biomarker for molecular staging of patients with colorectal cancer.20340131
Infection caused by Helicobacter pylori, CarcinogenesisEpigenetic AlterationsRole of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis.20345486
Squamous cell carcinoma of skinEpigenetic AlterationsAberrant DNA methylation associated with MTHFR C677T genetic polymorphism in cutaneous squamous cell carcinoma in renal transplant patients.20346029
Primary malignant neoplasmEpigenetic AlterationsChanges in genomic DNA methylation associated with cancer include global DNA hypomethylation and gene-specific hyper- or hypomethylation.20346029
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsDetection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker.20349219
Malignant neoplasm of stomach, NeoplasmsEpigenetic AlterationsOur results indicate that the detection of miRNA in peripheral blood may be a novel tool for monitoring circulating tumor cells in patients with gastric cancers.20349219
Colorectal Cancer PathwayEpigenetic AlterationsAntioxidant and DNA methylation-related nutrients and risk of distal colorectal cancer.20352485
Colorectal Cancer PathwayEpigenetic AlterationsOur findings provide evidence that antioxidant and DNA methylation-related nutrients may lower the risk of distal colorectal cancer in whites, and selenium may lower risk in African Americans.20352485
Malignant Neoplasms, Non-Small Cell Lung CarcinomaEpigenetic AlterationsEpigenetic silencing of secreted frizzled-related protein (SFRP) genes, antagonists of the WNT pathway, contributes to the pathogenesis of several cancers including non-small cell lung cancer (NSCLC).20353273
Carcinogenesis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn conclusion, epigenetic inactivation of SFRP1 is a common event contributing to lung carcinogenesis and maybe used as a potential biomarker for NSCLC in Chinese population.20353273
Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients.20353279
melanomaEpigenetic AlterationsMicroRNA expression profiles associated with mutational status and survival in malignant melanoma.20357817
NRAS gene, melanomaEpigenetic AlterationsIn conclusion, our findings show miRNA dysregulation in malignant melanoma and its relation to established molecular backgrounds of BRAF and NRAS oncogenic mutations.20357817
melanomaEpigenetic AlterationsSeveral miRNAs were differentially expressed between melanocytes and melanomas as well as melanoma cell lines.20357817
NeoplasmsEpigenetic AlterationsInhibition of RASSF2 expression enhances the transforming effects of K-Ras, and epigenetic inactivation of RASSF2 is frequently detected in mutant Ras-containing primary tumors.20368356
Cytogenetically normal acute myeloid leukemia, Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe R172 IDH2 mutations, previously unreported in AML, characterize a novel subset of CN-AML patients lacking other prognostic mutations and associate with unique gene- and microRNA-expression profiles that may lead to the discovery of novel, therapeutically targetable leukemogenic mechanisms.20368543
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe highest expressed gene and microRNAs in R172 IDH2-mutated patients compared with the IDH1/IDH2wt patients were APP (previously associated with complex karyotype AML) and miR-1 and miR-133 (involved in embryonal stem-cell differentiation), respectively.20368543
cervical cancerEpigenetic AlterationsOur results suggest that TSG101 down-regulation in cervical cancer cells is not regulated by genetic or epigenetic events.20372822
Primary malignant neoplasmEpigenetic AlterationsGlobal hypomethylation is a common epigenetic event in cancer.20374511
Cerebrovascular accidentEpigenetic AlterationsA functional variant in the 3-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211.20378606
Malignant NeoplasmsEpigenetic AlterationsThe alteration of DNA methylation is one of the most common epigenetic changes in human cancers.20381114
NeoplasmsEpigenetic AlterationsDiet, physical activity, and body size associations with rectal tumor mutations and epigenetic changes.20383576
NeoplasmsEpigenetic AlterationsThese data suggest that diet and lifestyle factors are associated with specific types of rectal tumor mutations and epigenetic changes.20383576
Non-Small Cell Lung CarcinomaEpigenetic AlterationsTherefore, we address this point by the identification of microRNAs that in non-small cell lung cancer (NSCLC) modulate PED levels.20388802
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAberrant expression of microRNAs (miRNAs) has been associated with clinical outcome in patients with chronic lymphocytic leukemia (CLL).20393129
Acute myocardial infarctionEpigenetic AlterationsPlasma microRNA 499 as a biomarker of acute myocardial infarction.20395621
myocardial injuryEpigenetic AlterationsRecently, we reported that miRNA 208 (miR-208) is produced exclusively in the rat myocardium and that plasma miR-208 is a biomarker of myocardial injury in rats.20395621
Malignant NeoplasmsEpigenetic AlterationsEvidence exists that microRNA (miRNA), which regulates gene expression, is frequently deregulated in cancers.20402672
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe increased expressions of Ago2 and TNRC6A in both PCA and ESCC compared with their normal cells suggested that over-expression of these proteins may be related to miRNA functions and might play a role in tumorigenesis of PCA and ESCC.20402672
Liver carcinomaEpigenetic AlterationsEpigenetic methylation and expression of caspase 8 and survivin in hepatocellular carcinoma.20403046
Hollings Cancer CenterEpigenetic AlterationsIn conclusion, epigenetic alteration by promoter methylation of caspase 8 and survivin may constitute an important regulatory mechanism for expression of those genes in HCC.20403046
Malignant NeoplasmsEpigenetic AlterationsMicro-RNAs (miRNAs) are involved in the pathogenesis of diverse human cancers, including PTC.20406109
Myeloid Leukemia, ChronicEpigenetic AlterationsExpression, epigenetic regulation, and humoral immunogenicity of cancer-testis antigens in chronic myeloid leukemia.20409582
Adenocarcinoma of large intestineEpigenetic AlterationsAssociation of microRNA expression with microsatellite instability status in colorectal adenocarcinoma.20413677
Clinical CoordinatorEpigenetic AlterationsWhen miRNA expression was compared with clinicopathologic features and MSI status, eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203, -133b, and -223) were over-expressed in CRC relative to mucosa, and nine (miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC.20413677
Clinical Coordinator, Malignant NeoplasmsEpigenetic AlterationsOur findings indicate that miRNA expression in CRC is associated with MSI subgroups, including low MSI and HNPCC-associated cancers, and that miRNAs may have posttranscriptional gene regulatory roles in these MSI subgroups and possible effects on the clinicopathologic and biomarker characteristics.20413677
Non-Cancer Related Death, ovarian neoplasm, Serous cystadenoma, borderline malignancyEpigenetic AlterationsIts methylation can be used as a novel epigenetic biomarker in discriminating ovarian cancer from non-cancer or borderline tumors.20421128
Primary malignant neoplasmEpigenetic AlterationsEpigenetic regulation of Wnt signaling pathway in urological cancer.20421722
Bladder NeoplasmEpigenetic AlterationsWe concluded that epigenetic deregulation of Wnt pathway inhibitors may contribute to aberrant activation of Wnt signaling pathway in bladder, prostate and renal tumors.20421722
Clinical Coordinator, Colorectal Carcinoma, NeoplasmsEpigenetic AlterationsRecent findings suggest that epigenetic inactivation of multiple tumor suppressor genes plays an important role in the tumorigenesis of colorectal carcinoma (CRC).20423473
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDifferential expression of specific microRNA and their targets in acute myeloid leukemia.20425795
Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe showed that miRNA expression profiling reveals distinctive miRNA signatures that correlate with cytogenetic and molecular subtypes of AML.20425795
FLT3 Internal Tandem Duplication, nucleophosmin, Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe observed a significant differentially expressed miRNA profile that characterizes two subgroups of AML with different mechanism of leukemogenesis: core binding factor (CBF) and cytogenetically normal AML with mutations in the genes of NPM1 and FLT3-ITD.20425795
Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe demonstrated, for the first time, the inverse correlation of expression levels between miRNA and their targets in specific AML genetic groups.20425795
Malignant NeoplasmsEpigenetic AlterationsAltered expression of miRNA is known to induce various human malignancies.20428818
Malignant Neoplasms, Squamous cell carcinoma of esophagusEpigenetic AlterationsMiR-21, which is an oncogenic miRNA in various malignancies, was also up-regulated in HNSCC and ESCC compared to paired normal squamous epithelia.20428818
Squamous cell carcinoma, Squamous cell carcinoma of esophagusEpigenetic AlterationsThese results suggest that miR-205 might be a specific marker miRNA of both normal and malignant squamous epithelia, while miR-21 might be a putative oncogenic miRNA in HNSCC and ESCC.20428818
Squamous cell carcinoma, Squamous cell carcinoma of the head and neck, Squamous cell carcinoma of esophagusEpigenetic AlterationsExpression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC.20428818
Squamous cell carcinoma, Malignant Neoplasms, Squamous cell carcinoma of esophagusEpigenetic AlterationsWe examined the expression of miRNAs in squamous cell carcinoma of human head and neck (HNSCC) and esophagus (ESCC), compared to that in normal squamous epithelia as well as malignancies of other organs.20428818
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer.20429937
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsWe adopt and report a systematic approach to identify the most stable reference genes for miRNA expression studies by RT-qPCR in colorectal cancer (CRC).20429937
Clinical CoordinatorEpigenetic AlterationsHigh-throughput miRNA profiling was performed on ten pairs of CRC and normal tissues.20429937
NeoplasmsEpigenetic AlterationsAs such the stability of a panel of miRNAs was examined on 35 tumour and 39 normal tissues.20429937
NeoplasmsEpigenetic AlterationsThe effects of normalisers on the relative quantity of established oncogenic (miR-21 and miR-31) and tumour suppressor (miR-143 and miR-145) target miRNAs were assessed.20429937
NeoplasmsEpigenetic AlterationsThe combined use of miR-16 and miR-345 to normalise expression data enabled detection of a significant dysregulation of all four target miRNAs between tumour and normal colorectal tissue.20429937
CarcinogenesisEpigenetic AlterationsAnalysis of DNA methylation status of the promoter of human telomerase reverse transcriptase in gastric carcinogenesis.20430247
NeoplasmsEpigenetic AlterationsCalcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors.20432164
melanomaEpigenetic AlterationsSignatures of microRNAs and selected microRNA target genes in human melanoma.20442294
melanomaEpigenetic AlterationsBecause data presently available on miRNA expression in melanoma are inconsistent thus far, we applied several different miRNA detection and profiling techniques on a panel of 10 cell lines and 20 patient samples representing nevi and primary or metastatic melanoma.20442294
melanomaEpigenetic AlterationsNevertheless, we identified miRNA-200c to be consistently downregulated in melanocytes, melanoma cell lines, and patient samples, whereas miRNA-205 and miRNA-23b were markedly reduced only in patient samples.20442294
melanomaEpigenetic AlterationsOur findings define miRNAs and miRNA target genes that offer candidate biomarkers in human melanoma.20442294
palladiumEpigenetic AlterationsMethylation of SNCA intron 1 was reduced in DNA from sporadic PD patients substantia nigra, putamen, and cortex, pointing toward a yet unappreciated epigenetic regulation of SNCA expression in PD.20445061
Malignant Neoplasms, Lymphoma, Non-Hodgkin, Lymphoma, Large-Cell, Follicular, Chronic Lymphocytic LeukemiaEpigenetic AlterationsTargeting aberrant DNA hypermethylation in chronic lymphocytic leukaemia (CLL) and non-Hodgkin lymphoma (NHL) with decitabine may reverse epigenetic silencing in B-cell malignancies.20456354
Esophageal carcinomaEpigenetic Alterations[Genetic and epigenetic changes of FHIT gene in patients with esophageal cancer].20458975
Obesity, Esophageal carcinomaEpigenetic AlterationsAssociations of risk factors obesity and occupational airborne exposures with CDKN2A/p16 aberrant DNA methylation in esophageal cancer patients.20459442
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsQuantitative epigenetic subclassification of rectal cancers has clinical utility in distinguishing tumors with increased risk for local recurrence and may help tailor treatment regimens for locoregional control.20460484
ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsMicroRNA-21 (miR-21) was reported to be overexpressed and contributes to invasion and gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC).20460539
Myeloid Leukemia, ChronicEpigenetic AlterationsWe found that imatinib treatment of chronic myeloid leukemia patients rapidly normalizes the characteristic miRNA expression profile, suggesting that miRNAs may serve as a novel clinically useful biomarker in this disease.20460641
Myeloid Leukemia, ChronicEpigenetic AlterationsMicro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia.20460641
Malignant Neoplasms, Myeloid Leukemia, ChronicEpigenetic AlterationsAberrant expression of miRNAs has been described in many human cancers, including chronic myeloid leukemia.20460641
Myeloid Leukemia, ChronicEpigenetic AlterationsExpression changes in the same miRNAs were consistently found in an additional cohort of chronic myeloid leukemia patients, as compared to healthy subjects.20460641
Breast Carcinoma, Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsThe quantitative detection of aberrant DNA methylation in serum samples may be a promising high throughput approach for the diagnosis of breast cancer including DCIS.20466412
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsUp-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition.20467341
diabeticEpigenetic AlterationsAutopsy pancreas samples from 40 type 2 diabetic and 15 nondiabetic patients were used to detect microRNA-375 expression using real-time quantitative polymerase chain reaction.20467341
diabeticEpigenetic AlterationsPancreatic microRNA-375 expression was increased in type 2 diabetic patients comparing with the nondiabetic patients (median, 4.02 for the diabetic patients vs 0.92 for the nondiabetic patients; P = 0.0001).20467341
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsUp-regulated microRNA-375 is associated with type 2 diabetes and pancreatic islet amyloid formation and beta-cell deficit.20467341
Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionEpigenetic AlterationsmicroRNA-375 may serve as a biomarker for known and novel pathways in the pathogenesis of type 2 diabetes related to islet amyloid deposition and beta-cell dysfunction.20467341
Degenerative polyarthritis, Rheumatoid ArthritisEpigenetic AlterationsPlasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis.20470394
Degenerative polyarthritisEpigenetic AlterationsThe expression patterns of miRNAs in synovial fluid of OA were similar to miRNAs secreted by synovial tissues.20470394
Right armEpigenetic AlterationsSynovial fluid miRNAs of RA were likely to originate from synovial tissues and infiltrating cells.20470394
Degenerative polyarthritis, Right armEpigenetic AlterationsPlasma miR-132 well differentiated HCs from patients with RA or OA, while synovial fluid miRNAs differentiated RA and OA.20470394
Breast Carcinoma, NeoplasmsEpigenetic AlterationsOur study underscores the potential utility of DNA methylation of these genes in serum as a promising biomarker and can serve as a surrogate for tumor DNA methylation for diagnosis and prognosis of breast cancer.20470789
Parkinson Disease, FGF20 protein, humanEpigenetic AlterationsFGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinsons disease in Spanish patients.20471450
Breast Carcinoma, Neoplastic disease, NeoplasmsEpigenetic AlterationsSilencing tumor suppressor genes via DNA methylation has established hypermethylation as one of the most frequent molecular alterations that may initiate and drive many types of human neoplasia including breast cancer.20471512
Breast Carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA.20471512
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsDetecting such epigenetic changes in DNA derived not only from tumor tissue, but also from bodily fluids, may be a promising target for the molecular analysis of cancer.20471512
Primary malignant neoplasmEpigenetic AlterationsAbnormal DNA methylation is a feature of most types of cancer, which is reflected in cell-free circulating DNA in plasma.20473856
NeoplasmsEpigenetic AlterationsIt is, however, unknown whether surgical removal of the tumor and subsequent therapy induces changes in plasma DNA methylation, which can be used to monitor treatment.20473856
Colorectal Cancer Pathway, Lynch SyndromeEpigenetic AlterationsDe novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one.20473912
Lynch SyndromeEpigenetic AlterationsConstitutional epimutations of the MLH1 gene, characterized by soma-wide methylation of a single allele of the promoter and allelic transcriptional silencing, have been identified in a subset of Lynch syndrome cases lacking a sequence mutation in MLH1.20473912
NeoplasmsEpigenetic AlterationsAnalysis of 13 tumors from seven individuals with constitutional MLH1 epimutations showed eight tumors had lost the second MLH1 allele, two tumors had a novel pathogenic missense mutation and three had retained heterozygosity.20473912
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsIn both cases, cancer had arisen because of the de novo occurrence of a constitutional MLH1 epimutation and somatic loss-of-heterozygosity of the functional allele in the tumors.20473912
NeoplasmsEpigenetic AlterationsIt is clear that the second hit in MLH1 epimutation-associated tumors typically has a genetic not epigenetic basis.20473912
Carcinogenesis, Stomach CarcinomaEpigenetic AlterationsOur findings demonstrate that reduced RASAL1 expression, partly due to genetic and epigenetic changes, contributes to gastric carcinogenesis, and also re-emphasize the importance of RAS signaling in gastric cancer development.20473946
Loss of Chromosome 1pEpigenetic AlterationsChromosome 1p loss and epigenetic modifications were the major mechanisms contributing to PDAM downregulation.20477830
NeoplasmsEpigenetic AlterationsOur findings also suggest that single-nucleotide polymorphisms located in the binding region of the MRE-RAD50-NBS1 complex or microRNA targeted pathways may influence tumor development.20478923
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer.20479932
Carcinogenesis, NeoplasmsEpigenetic AlterationsThese findings provide new insights into the role of the ETS transcriptional network in prostate tumorigenesis and uncover previously unrecognized links between aberrant expression of ETS factors, deregulation of epigenetic effectors and silencing of tumor suppressor genes.20479932
Prostate Cancer PathwayEpigenetic AlterationsThe link between aberrant ETS activity and epigenetic gene silencing may be relevant for the clinical management of prostate cancer and design of new therapeutic strategies.20479932
Cervix carcinomaEpigenetic AlterationsThe anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma.20482749
Malignant NeoplasmsEpigenetic AlterationsEpigenetic gene silencing of secreted Wnt antagonists is considered a common event in a wide range of human malignancies.20482749
Cervix carcinomaEpigenetic AlterationsEpigenetic silencing of KLOTHO may occur during the late phase of cervical tumorigenesis, and consequent functional loss of KLOTHO as the secreted Wnt antagonist may contribute to aberrant activation of the canonical Wnt pathway in cervical carcinoma.20482749
Lupus Erythematosus, Systemic, Lupus ErythematosusEpigenetic AlterationsIn systemic lupus erythematosus (SLE), global and gene-specific DNA methylation changes have been demonstrated to occur.20483040
SLC24A3 geneEpigenetic AlterationsAberrant DNA methylation can also be found on selected randomly positive genes (WDR5, SLC24A3, PTPN22, LRP1B METT10D and CDH13).20483040
Lupus ErythematosusEpigenetic AlterationsSuch novel findings show the significance of H3K4me3 as a potential biomarker or promising target for epigenetic-based lupus therapies.20483040
Chronic heart failureEpigenetic AlterationsMicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients.20484156
Congestive heart failureEpigenetic AlterationsThe identified miRNAs might have a potential diagnostic and/or prognostic use in CHF.20484156
Chronic Lymphocytic LeukemiaEpigenetic AlterationsGenome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact.20484983
Chronic Lymphocytic LeukemiaEpigenetic AlterationsWe performed a genome-wide analysis of aberrant DNA methylation in chronic lymphocytic leukemia (CLL) using methylated CpG island amplification (MCA) coupled with a promoter microarray.20484983
Chronic Lymphocytic LeukemiaEpigenetic AlterationsWe identified 280 potential targets of aberrant DNA methylation in CLL.20484983
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThis study demonstrates that aberrant DNA methylation is common and has potential prognostic and therapeutic value in CLL.20484983
Clear cell adenocarcinoma of ovary, Ovarian Serous Adenocarcinoma, OSA protein, Drosophila, Neoplasms, EndometriomaEpigenetic AlterationsSpecific tumour suppressor genes with promoter methylation in ovarian clear cell adenocarcinoma (OCCA) can be one important epigenetic mark distinguishing OCCA from ovarian serous adenocarcinoma (OSA), benign endometriotic cysts and normal ovarian epitheliums.20486992
Chronic Lymphocytic LeukemiaEpigenetic AlterationsDetermination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia.20487546
Malignant neoplasm of urinary bladderEpigenetic AlterationsXPC epigenetic silence coupled with p53 alteration has a significant impact on bladder cancer outcome.20488473
Malignant neoplasm of urinary bladderEpigenetic AlterationsEpigenetic defects in the XPC gene impact bladder cancer malignant behavior and may also predict poor outcome in some bladder cancer cases, as characterized by p53 pathway alteration.20488473
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsPromoter methylation is a gene- and cancer type-specific epigenetic event that plays an important role in tumour development.20488783
Endometrial Carcinoma, Endometrial Serous Adenocarcinoma, Endometrioid tumorEpigenetic AlterationsAs endometrioid (endometrioid endometrial carcinoma, EEC) and serous endometrial cancers (uterine papillary serous carcinoma, UPSC) exhibit different clinical, histological and molecular genetic characteristics, we hypothesized that these differences may be reflected in epigenetic phenomena as well.20488783
Breast CarcinomaEpigenetic AlterationsMicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer.20490652
Breast CarcinomaEpigenetic AlterationsWe identified hsa-miRNA-30c as an independent predictor for clinical benefit of tamoxifen therapy in patients with advanced breast cancer.20490652
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are small RNA molecules that modulate gene expression and which have been implicated in cancer.20490652
Mammary NeoplasmsEpigenetic AlterationsThese five miRNAs were measured in an independent series of 246 estrogen receptor (ER)-positive primary breast tumors of patients who received tamoxifen for advanced disease by quantitative Real Time PCR.20490652
Colorectal Cancer PathwayEpigenetic AlterationsComprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features.20492682
Clinical CoordinatorEpigenetic AlterationsComprehensive DNA methylation profiling identified three CRC subgroups with distinctive clinicopathological and molecular features.20492682
Myeloid Leukemia, ChronicEpigenetic AlterationsThe epigenetic changes of TSGs are recently recognized as an abnormal mechanism contributing to the development of chronic myeloid leukemia (CML).20492726
Primary malignant neoplasmEpigenetic AlterationsAberrations of allelic replication timing are epigenetic markers observed in peripheral blood cells of cancer patients.20497575
Hematologic NeoplasmsEpigenetic AlterationsWe show that aberrant epigenetic markers are detected in patients with hematological malignancies from the time of diagnosis through to when they are scheduled to undergo alloSCT.20497575
AneuploidyEpigenetic AlterationsA demethylating anti-cancer drug, 5-azacytidine, applied in vitro to lymphocytes of patients prior to transplantation mimics the effect of transplantation: the epigenetic aberrations disappear while aneuploidy stays unchanged.20497575
Liver carcinomaEpigenetic Alterations[MicroRNA profiling in patients with hepatocellular carcinoma].20501372
Hollings Cancer CenterEpigenetic AlterationsHCC and LC samples have significantly different microRNA expression profiles.20501372
Hollings Cancer CenterEpigenetic AlterationsThree microRNAs exhibited higher expression in the HCC samples than in the LC samples.20501372
Hollings Cancer CenterEpigenetic AlterationsIn comparison with the LC samples, the HCC samples showed down-regulated expressions of 9 microRNAs.20501372
Hollings Cancer CenterEpigenetic AlterationsThese differentially expressed microRNAs may be involved in the pathogensis of HCC.20501372
Malignant Neoplasms, Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsMicroRNA-199a-3p (miR-199a-3p) is downregulated in several human malignancies including hepatocellular carcinoma (HCC).20501828
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNA) have rapidly emerged as modulators of gene expression in cancer in which they may have great diagnostic and therapeutic import.20501828
Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia.20504344
Chronic Lymphocytic LeukemiaEpigenetic AlterationsTo elucidate whether microRNAs are involved in the development of fludarabine resistance, we analyzed the expression of 723 human miRNAs before and 5-days after fludarabine mono-therapy in 17 CLL patients which were classified as responder or refractory to fludarabine treatment based on NCI criteria.20504344
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe expression of some microRNAs was also able to predict fludarabine resistance of 12 independent CLL patients.20504344
Breast CarcinomaEpigenetic AlterationsThese results suggest that gene methylation in breast cancer can potentially serve as epigenetic biomarkers and may contribute further to current breast cancer classification.20505321
Stomach CarcinomaEpigenetic AlterationsDNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae.20507321
Stomach CarcinomaEpigenetic AlterationsOur findings indicate that epigenetic IRF inactivation plays a key role in tumorigenesis of gastric cancer, and that inhibition of DNA methylation may restore the antitumor activity of interferons through up-regulation of IRFs.20507321
Carcinogenesis, NeoplasmsEpigenetic AlterationsDe novo DNA methylation is a relevant epigenetic mechanism, which represses gene transcription and commonly inactivates tumor suppressor genes in carcinogenesis.20514408
Breast CarcinomaEpigenetic AlterationsDNA methylation is aberrant in breast cancer and is likely to play a major role in disease progression.20515469
Breast Carcinoma, Hormone Receptor Positive Breast CarcinomaEpigenetic AlterationsIn this study, the DNA methylation status of 202 candidate loci was screened to identify those loci that may predict outcome in LNP/estrogen receptor-positive (ER+) breast cancer patients with adjuvant anthracycline-based chemotherapy.20515469
Breast CarcinomaEpigenetic AlterationsQuantitative bisulfite sequencing was used to analyze DNA methylation biomarker candidates in a retrospective cohort of 162 LNP/ER+ breast cancer patients, who received adjuvant anthracycline-based chemotherapy.20515469
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsGrowing evidence suggests that miRNAs have a significant role in tumor development and may constitute robust biomarkers for cancer diagnosis and prognosis.20518884
Gallbladder CarcinomaEpigenetic AlterationsCommon genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population.20520619
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) play critical roles in embryonic development and are frequently deregulated in human cancers.20525879
Primary malignant neoplasmEpigenetic AlterationsThe let-7 family members are tumor-suppressing miRNAs and are frequently downregulated in cancer cells.20525879
Squamous cell carcinoma of lungEpigenetic AlterationsEarly detection of squamous cell lung cancer in sputum by a panel of microRNA markers.20526284
Carcinoma of lungEpigenetic AlterationsWe have previously shown that microRNAs (miRNAs) were stably present in sputum and potentially useful in diagnosis of lung cancer.20526284
NeoplasmsEpigenetic AlterationsOn the surgical tissues, six miRNAs were identified, of which three were overexpressed and three were underexpressed in all 15 tumors.20526284
CarcinogenesisEpigenetic AlterationsMultiple genetic and epigenetic alterations in several genes are implicated in the multistep process of human gastric carcinogenesis.20530453
PSMG2 geneEpigenetic AlterationsTogether, these results provide a novel insight into the mechanisms involved in HCV-associated hepatocellular carcinomas, showing that reduced Gadd45beta expression may play a contributory role to this process, and providing evidence that HCV may interfere with epigenetic gene expression by altering promoter methylation.20530689
Hematologic NeoplasmsEpigenetic AlterationsEpigenetic therapies, including DNA methyltransferase and histone deacetylase inhibitors, represent important new treatment modalities in hematologic malignancies, but their mechanism of action remains unknown.20530795
Leukemia, Myelocytic, AcuteEpigenetic AlterationsFurthermore, it appears that epigenetic therapies have the capacity to induce a CTL response to MAGE antigens in vivo that may contribute to their clinical activity in AML.20530795
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsCirculating microRNAs are new and sensitive biomarkers of myocardial infarction.20534597
IschemiaEpigenetic AlterationsIn mice with acute hind-limb ischaemia, there was no increase in the plasma level of the above miRNAs.20534597
DamageEpigenetic AlterationsThese miRNAs represent novel biomarkers of cardiac damage.20534597
Helicobacter pyloriEpigenetic AlterationsUp-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells.20542134
Infection caused by Helicobacter pyloriEpigenetic AlterationsMicroRNAs (miRNAs) have recently emerged as key post-transcriptional regulators of gene expression, and their role in H. pylori infection is just beginning to be explored.20542134
Uterine NeoplasmsEpigenetic AlterationsMicroRNA signatures differentiate uterine cancer tumor subtypes.20542546
Endometrial Serous Adenocarcinoma, NeoplasmsEpigenetic AlterationsDistinct miRNA signatures in tumor versus normal samples and in endometrioid vs. uterine papillary serous carcinomas exist.20542546
Carcinosarcoma, NeoplasmsEpigenetic AlterationsAdditionally, carcinosarcomas have a unique miRNA signature from either the type I or II epithelial tumors.20542546
NeoplasmsEpigenetic AlterationsWe hypothesize that further understanding the miRNAs that separate these subtypes of EC will lead to biological insights into the different behavior of these tumors.20542546
Small cell carcinoma of lungEpigenetic AlterationsMicroRNA 92a-2*: a biomarker predictive for chemoresistance and prognostic for survival in patients with small cell lung cancer.20548249
Small cell carcinoma of lung, NeoplasmsEpigenetic AlterationsWe hypothesized that tumor microRNAs (miRNAs) could serve as predictive biomarkers for chemoresistance and prognostic biomarkers for survival of patients with SCLC treated with systemic chemotherapy.20548249
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAs an inhibitor of cyclin-dependent kinases, p16(INK4A) is an important tumour suppressor and inducer of cellular senescence that is often inactivated during the development of cancer by promoter DNA methylation.20548956
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA-125b suppresses the development of bladder cancer by targeting E2F3.20549700
Malignant NeoplasmsEpigenetic AlterationsmicroRNA-125b (miR-125b) was implicated to have close relationship with cell proliferation and differentiation, and downregulation of miR-125b was observed in various types of cancers.20549700
Primary malignant neoplasmEpigenetic AlterationsIn cancer, regulation of gene transcription can be mediated in a variety of ways.20551037
Neoplastic diseaseEpigenetic AlterationsMicroRNAs (miRNA) play an important role in a wide array of biological processes and are commonly dysregulated in neoplasia.20551304
Colorectal Neoplasms, AdenomaEpigenetic AlterationsmiRNA expression profiles from 29 patients showed higher expression of miR-21 and miR-106a in patients with adenomas and CRCs compared with individuals free of colorectal neoplasia.20551304
Colorectal NeoplasmsEpigenetic AlterationsThe stools of patients with colorectal neoplasms have unique and identifiable patterns of miRNA expression.20551304
Malignant tumor of colonEpigenetic AlterationsFecal MicroRNAs as novel biomarkers for colon cancer screening.20551304
Colorectal NeoplasmsEpigenetic AlterationsFecal miRNAs may be an excellent candidate for the development of a noninvasive screening test for colorectal neoplasms.20551304
Childhood LeukemiaEpigenetic Alterations[Detection of miRNA levels in leukemia patients by real-time quantitative PCR].20561445
NeoplasmsEpigenetic AlterationsDNA methylation profiling of phyllodes and fibroadenoma tumours of the breast.20563638
NeoplasmsEpigenetic AlterationsMethylation-sensitive high resolution melting (MS-HRM) was used to screen promoter DNA methylation changes in 86 phyllodes tumours (15 benign, 28 borderline, 43 malignant) and 26 fibroadenomas.20563638
Hematologic Neoplasms, Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation is a hallmark of cancer, and DNA methyltransferase inhibitors have demonstrated clinical efficacy in hematologic malignancies.20564122
Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation has been implicated as a key survival mechanism in cancer, whereby promoter hypermethylation silences genes essential for many cellular processes including apoptosis.20564325
NeoplasmsEpigenetic AlterationsThis epigenetic alteration affects promoter of genes having crucial cellular functions such as tumor suppressor, DNA repair, apoptosis, cell adhesion, etc.20571967
Colorectal NeoplasmsEpigenetic AlterationsWe also showed that epigenetic alteration of CDH1 is a major mechanism of the loss of E-cadherin protein expression in primary colorectal tumors.20571967
Malignant Neoplasms, Breast Carcinoma, disease stageEpigenetic AlterationsSystemic miRNA-195 differentiates breast cancer from other malignancies and is a potential biomarker for detecting noninvasive and early stage disease.20576643
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsData have emerged documenting altered systemic miRNA expression across a spectrum of cancers; however, it remains uncertain as to whether circulating miRNAs are tumor specific.20576643
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsThese findings suggest that individual cancers display specific systemic miRNA profiles, which could aid in discriminating among cancer types.20576643
NeoplasmsEpigenetic AlterationsThe potential of microRNAs (miRNAs) as novel tumor markers has been the focus of recent scrutiny because of their tissue specificity, stability, and association with clinicopathological parameters.20576643
Breast CarcinomaEpigenetic AlterationsA combination of three circulating miRNAs, including miR-195, further enhanced the discriminative power of this test for breast cancer to 94%.20576643
Primary malignant neoplasmEpigenetic AlterationsThis finding is of notable clinical consequence because it illustrates the potential of systemic miRNAs as sensitive, specific, noninvasive cancer biomarkers.20576643
Acute lymphocytic leukemiaEpigenetic Alterations14q32/miRNA clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a.20578197
Acute lymphocytic leukemiaEpigenetic AlterationsWe demonstrate that a subset of ALL cases bearing 14q32 LOH showed a down-regulation of miRNA 14q32 clusters, which is directly linked to the submicroscopic chromosomal deletion.20578197
Acute lymphocytic leukemiaEpigenetic AlterationsThese results suggest that 14q32/miRNA clusters LOH may be another mechanism involved in lymphoid B cell transformation and differentiation and therefore, could be used as a diagnostic marker and therapeutic target in subsets of ALL.20578197
Malignant Neoplasms, CarcinogenesisEpigenetic AlterationsSince DNA methylation-based silencing of hsa-miR-124 occurs in various human cancers, we studied the frequency and functional effects of hsa-miR-124 methylation in cervical carcinogenesis.20579385
Carcinogenesis, Mirn124a microRNA, human, cervical cancerEpigenetic AlterationsDNA methylation-based silencing of hsa-miR-124 is functionally involved in cervical carcinogenesis and may provide a valuable marker for improved detection of cervical cancer and its high-grade precursor lesions.20579385
Primary malignant neoplasmEpigenetic AlterationsA substantial number of microRNAs (miRNAs) is subject to epigenetic silencing in cancer.20579385
cervical cancer, NeoplasmsEpigenetic AlterationsAlthough epigenetic silencing of tumour suppressor genes is an important feature of cervical cancer, little is known about epigenetic silencing of miRNAs.20579385
Pancreatic carcinomaEpigenetic AlterationsMicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation.20579395
Primary malignant neoplasmEpigenetic AlterationsRecently, the microRNA-200 family was reported to affect cancer biology by regulating epithelial to mesenchymal transition (EMT).20579395
Stomach CarcinomaEpigenetic AlterationsIn conclusion, our results suggested that S100A6 plays an important role in the progression of gastric cancer, affecting patient prognosis, and is up-regulated by epigenetic regulation.20581057
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumor-related genes by CpG island methylation is an important mechanism for the development of many tumors, including gastric carcinoma.20585880
Ulcerative ColitisEpigenetic AlterationsIncreased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis.20586854
Primary malignant neoplasm, Cessation of lifeEpigenetic AlterationsIt has been recently reported that miRNA have critical functions in key biological processes such as cell proliferation and cell death in various cancer cells.20586854
Gastrointestinal inflammation, Ulcerative ColitisEpigenetic AlterationsUpregulated miRNA may be responsible for the development of intestinal inflammation in UC.20586854
Colorectal Cancer PathwayEpigenetic AlterationsIn this prospective study of older women, cigarette smoking was associated with the MSI-high, CIMP-positive, and BRAF mutation-positive colorectal cancer subtypes, which indicates that epigenetic modification may be functionally involved in smoking-related colorectal carcinogenesis.20587792
NeoplasmsEpigenetic AlterationsWe investigated the likelihood of detecting aberrant DNA methylation of tumor suppressor genes in plasma samples of patients with abnormalities of the lung detected upon computed tomography (CT) scan.20592015
Coronary Artery DiseaseEpigenetic AlterationsCirculating microRNAs in patients with coronary artery disease.20595655
Coronary Artery DiseaseEpigenetic AlterationsTo address the regulation of circulating microRNAs in patients with stable coronary artery disease.20595655
Coronary Artery DiseaseEpigenetic AlterationsInterestingly, most of the highly expressed microRNAs that were lower in the blood of patients with coronary artery disease are known to be expressed in endothelial cells (eg, miR-126 and members of the miR-17 approximately 92 cluster).20595655
Coronary Artery DiseaseEpigenetic AlterationsTo prospectively confirm these data, we detected selected microRNAs in plasma of 36 patients with coronary artery disease and 17 healthy volunteers by quantitative PCR.20595655
Coronary Artery DiseaseEpigenetic AlterationsIn contrast, cardiac muscle-enriched microRNAs (miR-133a, miR-208a) tend to be higher in patients with coronary artery disease.20595655
Coronary Artery DiseaseEpigenetic AlterationsCirculating levels of vascular and inflammation-associated microRNAs are significantly downregulated in patients with coronary artery disease.20595655
Hollings Cancer CenterEpigenetic AlterationsAmong the 25 HCC samples analyzed, microRNA-183 was significantly up-regulated (twofold to 367-fold) in 17 samples compared with the matching nontumoral liver tissues.20602797
Liver carcinomaEpigenetic AlterationsIn recent years, some miRNAs have been reported to be connected closely with the development of human hepatocellular carcinoma.20602797
Hollings Cancer CenterEpigenetic AlterationsIn our previous studies, a set of miRNAs were revealed to be dysregulated in HCC tissues.20602797
Hollings Cancer CenterEpigenetic AlterationsHowever, the functions of these miRNAs in HCC remain largely undefined.20602797
Epilepsy, Epilepsy, Temporal LobeEpigenetic AlterationsHowever, factors that influence MMP-9 gene expression, post-transcriptional modifications, or the balance between activation and inhibition of MMP-9 may play a role in the pathogenesis of TLE and other epileptic syndromes.20605480
CarcinogenesisEpigenetic AlterationsAberrant DNA methylation changes are common somatic alterations in prostate carcinogenesis.20606036
Metastasis, Renal Cell Carcinoma PathwayEpigenetic AlterationsExpression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy.20609231
Neoplasms, Refractory Cytopenia of ChildhoodEpigenetic AlterationsThe expression levels of miRNA-155 (p < 0.0001), miRNA-210 (p < 0.0001), miRNA-106a (p < 0.0001) and miRNA-106b (p < 0.0001) were significantly over-expressed in tumor tissue, whereas the expression of miRNA-141 (p < 0.0001) and miRNA-200c (p < 0.0001) were significantly decreased in RCC samples.20609231
NeoplasmsEpigenetic AlterationsThere were no significant differences between expression levels of miRNA-182 and miRNA-200b in tumor samples and renal parenchyma.20609231
Metastasis, Neoplasms, Refractory Cytopenia of ChildhoodEpigenetic AlterationsOur data suggest that expression levels of miRNA-106b are significantly lower in tumors of patients who developed metastasis (p = 0.030) and miR-106b is a potential predictive marker of early metastasis after nephrectomy in RCC patients (long-rank p = 0.032).20609231
Refractory Cytopenia of ChildhoodEpigenetic AlterationsFor the first time, we have identified a prognostic significance of miRNA-106b, which, after validation on a larger group of patients, maybe useful as a promising biomarker in patients with RCC.20609231
Renal Cell Carcinoma PathwayEpigenetic AlterationsPrevious studies have shown altered expression levels of several microRNAs in renal cell carcinoma.20609231
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsDetection of differentially expressed microRNAs in serum of pancreatic ductal adenocarcinoma patients: miR-196a could be a potential marker for poor prognosis.20614181
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have long been established to remain stable in circulation, and dysregulated miRNAs in serum of tumor patients could potentially serve as novel biomarkers.20614181
Gastrointestinal Carcinoid Tumor, Neoplasms, Bronchogenic CarcinomaEpigenetic AlterationsIn SCLC tumors, as well as bronchial carcinoids and carcinoids of gastrointestinal origin, recurrent CN alterations were observed in 203 genes, including the RB1 gene and 59 microRNAs of which 51 locate in the DLK1-DIO3 domain.20615970
Malignant neoplasm of stomachEpigenetic AlterationsOur results suggest that genetic, epigenetic, and protein expression pattern alterations of the SDHB gene might play a minor role in the development or progression of gastric cancers.20618733
Hepatitis BEpigenetic AlterationsThe hepatitis B virusxprotein (HBx) has been implicated as a potential trigger of the epigenetic deregulation of some genes, but the underlying mechanism remains unknown.20620135
EpitheliomaEpigenetic AlterationsLow frequency of epigenetic events in urothelial tumors in young patients.20620398
NeoplasmsEpigenetic AlterationsSince many carcinogenic events occur at the epigenetic rather than the genetic level, we analyzed the same tumors for alterations in DNA hypermethylation.20620398
EpitheliomaEpigenetic AlterationsUrothelial tumors in patients younger than 19 years have a low rate of epigenetic alteration.20620398
Transitional cell carcinoma of bladder, NeoplasmsEpigenetic AlterationsTumors in patients older than 20 years have epigenetic profiles similar to those of tumors in patients within the typical bladder urothelial cell carcinoma age range.20620398
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNAs, which are endogenously expressed regulatory noncoding RNAs, have an altered expression in colorectal cancer.20620599
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Chromosome AberrationsEpigenetic AlterationsThis is the first approach to generate an expression profile of 365 microRNAs in myelodysplastic syndromes (MDS) with normal karyotype (n=12) and distinct cytogenetic aberrations (n=12).20627384
Malignant neoplasm of urinary bladderEpigenetic AlterationsDNA methylation may be important for downregulation of hepaCAM expression in bladder cancer.20628239
NeoplasmsEpigenetic AlterationsAlcohol consumption and rectal tumor mutations and epigenetic changes.20628283
NeoplasmsEpigenetic AlterationsEpigenetic silencing of Wnt antagonists and expression changes in genes associated with Wnt response pathways occur in early sporadic colorectal tumourigenesis, indicating that tumour cells are more sensitive to Wnt growth factors and respond differently.20628379
Esophageal carcinomaEpigenetic AlterationsMiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma.20628822
Ulcerative Colitis-Associated Colorectal Adenocarcinoma, CarcinogenesisEpigenetic AlterationsAs alterations of pro-apoptotic genes might cause instability in the balance of cell-turnover during chronic inflammatory processes, epigenetic silencing of DAPK might be involved in the carcinogenesis of ulcerative colitis-associated carcinoma (UCC).20630662
DLEC1 protein, human, Non-Small Cell Lung CarcinomaEpigenetic AlterationsFrequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in non-small-cell lung cancer.20630829
MYELODYSPLASTIC SYNDROME, Refractory anemia with ringed sideroblastsEpigenetic AlterationsThese results demonstrated, for the first time, the differential ncRNA expression profile between MDS-RARS and healthy individuals, in CD34+ cells and stromal cells, suggesting that ncRNAs may play an important role during the development of myelodysplastic syndromes.20633296
Serrated Nodule, Adenomatous hyperplasiaEpigenetic AlterationsDNA methylation varies throughout the normal colorectal mucosa and DNA methylation in normal appearing mucosa is associated with serrated and adenomatous neoplasia elsewhere within the colorectum.20635146
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsIdentifying tumor suppressor genes silenced by promoter CpG methylation uncovers mechanisms of tumorigenesis and identifies new epigenetic biomarkers for early cancer detection.20639048
Renal Cell Carcinoma PathwayEpigenetic AlterationsWe explored its epigenetic alteration in renal cell carcinoma and possible clinicopathological association.20639048
NeoplasmsEpigenetic AlterationsThe KRAS oncogene and altered levels of the microRNA (miRNA) let-7 are associated with an increased risk of developing solid tumors.20647319
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusEpigenetic AlterationsMicroRNAs (miRNAs) have been implicated in the epigenetic regulation of key metabolic, inflammatory, and antiangiogenic pathways in type 2 diabetes (DM) and may contribute to common disease complications.20651284
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsPlasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes.20651284
Diabetes MellitusEpigenetic AlterationsWe reveal a plasma miRNA signature for DM that includes loss of endothelial miR-126.20651284
Non-Small Cell Lung CarcinomaEpigenetic AlterationsBoth aberrant localization and epigenetic changes are associated with aberrant expression of connexin 43 in human NSCLC.20651379
Glioblastoma MultiformeEpigenetic AlterationsEpigenetic silencing of the MGMT gene through promoter methylation correlates with improved survival in Glioblastoma Multiforme (GBM) patients receiving concurrent chemoradiotherapy.20652362
NeoplasmsEpigenetic AlterationsDNA hypermethylation of promoter CpG islands is known to be a major mechanism for epigenetic inactivation of tumor suppressor genes.20652500
Adenocarcinoma of pancreasEpigenetic AlterationsMicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma.20652642
Malignant NeoplasmsEpigenetic AlterationsDetection of aberrant microRNA (miR) expression may contribute to diagnosis and prognosis of various cancers.20652642
CarcinogenesisEpigenetic AlterationsTo investigate aberrant DNA methylation of CpG islands and subsequent low- or high-level DNA microsatellite instability (MSI) which is assumed to drive colon carcinogenesis.20653064
Colorectal Carcinoma, AdenomaEpigenetic AlterationsDNA of healthy individuals, adenoma (tubular or villous/tubulovillous) patients, and colorectal carcinoma patients who underwent colonoscopy was used for assessing the prevalence of aberrant DNA methylation of human DNA mismatch repair gene mutator L homologue 1 (hMLH1), Cyclin-dependent kinase inhibitor 2A (CDKN2A/p16), and O-6-methylguanine DNA methyltransferase (MGMT), as well as their relation to MSI.20653064
Liver carcinomaEpigenetic AlterationsMicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells.20655737
Liver carcinomaEpigenetic AlterationsRecently, some miRNAs have been reported to be connected closely with the development of human hepatocellular carcinoma.20655737
Hollings Cancer CenterEpigenetic AlterationsHowever, the functions of these miRNAs in HCC remain largely undefined.20655737
Neoplasms, Malignant Neoplasms, SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, AcuteEpigenetic AlterationsDNA methylation is one of the major epigenetic changes in human cancers, leading to silencing of tumor suppressor genes, with a pathogenetic role in tumor development and progression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).20655775
Malignant Neoplasms, Therapy-related acute myeloid leukemia and myelodysplastic syndrome, ConstitutionalEpigenetic AlterationsThe significant association with previous malignancy subtypes may underlie a likely susceptibility to methylation of specific targets and a role for constitutional epimutations as predisposing factors for the development of therapy-related myeloid neoplasm.20655775
CDISC SDTM Lesion Complexity TerminologyEpigenetic AlterationsChemotherapy and individual genetic predisposition have a role in t-MDS/AML development, the identification of specific epigenetic modifications may explain complexity and genomic instability of these diseases and give the basis for targeted-therapy.20655775
FLT3 Internal Tandem Duplication, Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsFLT3-ITD identifies older CN-AML patients with molecular high risk and is associated with gene- and microRNA-expression signatures that provide biologic insights for novel therapeutic approaches.20656931
Adenocarcinoma of pancreasEpigenetic AlterationsBased upon the clinico-pathologic features of these patients and the role of WRN in experimental models, we propose that its loss-of-function predisposes the development of pancreatic adenocarcinoma through epigenetic silencing or loss-of-heterozygosity of WRN.20657174
Inflammatory Breast CarcinomaEpigenetic AlterationsIntegrated miRNA and mRNA expression profiling of the inflammatory breast cancer subtype.20664596
Malignant NeoplasmsEpigenetic AlterationsAberrant microRNA (miRNA) expression is presently proposed to correlate with various human cancers and common single-nucleotide polymorphisms (SNP) at miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation.20666778
Pituitary AdenomaEpigenetic AlterationsDown-regulation of Wee1 kinase by a specific subset of microRNA in human sporadic pituitary adenomas.20668041
Primary malignant neoplasmEpigenetic AlterationsCancer is known to have epigenetic inputs, with events like genomewide hypomethylation and gene-specific hypermethylation of DNA.20670142
AbnormalEpigenetic AlterationsWe find that DNA methylation was more prevalent in patients with normal compared to karyotypically abnormal AML for most genes; CEBPa (20% vs 9%), CTNNA1 (14% vs 4%), and ER (41% vs 19%) (p < 0.05 for all comparisons).20671427
Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia.20671427
Schizophrenia, Bipolar DisorderEpigenetic AlterationsMicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.20675101
SchizophreniaEpigenetic AlterationsThe number of miRNAs identified is growing rapidly and approximately one-third is expressed in the brain where they have been shown to affect neuronal differentiation, synaptosomal complex localization and synapse plasticity, all functions thought to be disrupted in schizophrenia.20675101
Dupuytren ContractureEpigenetic AlterationsUnique microRNA profile in Dupuytrens contracture supports deregulation of b-catenin pathway.20676061
Dupuytren ContractureEpigenetic AlterationsIdentification of unique miRNA expression in Dupuytrens contracture may lead to the development of novel molecular therapy for its treatment.20676061
Dupuytren ContractureEpigenetic AlterationsThe miRNAs identified may have a function in the pathogenesis of Dupuytrens contracture by targeting and regulating important pathways.20676061
Breast CarcinomaEpigenetic AlterationsNo evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer.20680678
Breast CarcinomaEpigenetic AlterationsSince HIF-1a is frequently expressed in breast carcinomas, we evaluated DNA methylation as a possible mechanism of silencing one or more of the VHL complex genes.20680678
Breast Carcinoma, VHL protein, humanEpigenetic AlterationsEpigenetic silencing by promoter DNA methylation for VHL and the complex genes, CUL2, elongin C (TCEB1), elongin B (TCEB2) and RBX1, is unlikely to play a role in HIF-1a upregulation in breast carcinomas.20680678
CarcinogenesisEpigenetic AlterationsEpigenetic silencing of miR-137 is an early event in colorectal carcinogenesis.20682795
CarcinogenesisEpigenetic AlterationsHerein, we describe the epigenetic regulation of miR-137 and its contribution to colorectal carcinogenesis.20682795
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsGlobal downregulation of microRNAs (miRNA) is a common feature in colorectal cancer (CRC).20682795
Breast Carcinoma, Ductal Carcinoma, NeoplasmsEpigenetic AlterationsPromoter hypermethylation of 8 tumor suppressor genes (RASSF1A, APC, HIN1, BRCA1, CYCLIND2, RARbeta, CDH1 and TWIST1) and DNA methylation for three repetitive elements (LINE1, Sat2 and Alu) were analyzed in invasive ductal carcinoma of the breast, paired adjacent normal tissue and WBC from 40 breast cancer patients by the MethyLight assay.20682973
NeoplasmsEpigenetic AlterationsDNA methylation for the three repetitive elements was lower in tumor compared to adjacent tissue and WBC DNA.20682973
Primary malignant neoplasmEpigenetic AlterationsHypermethylation of the CpG islands of gene promoter is one of the earliest and most frequent epigenetic alterations leading to cancer as well as in its development.20683150
ovarian neoplasmEpigenetic AlterationsWhole blood-derived miRNA profiles as potential new tools for ovarian cancer screening.20683447
NeoplasmsEpigenetic AlterationsMS-MLPA detects genetic and epigenetic aberrations of 37 tumor suppressor genes (TSG) in a single reaction and might, therefore, avoid the cumbersome single gene analyses.20683729
NeoplasmsEpigenetic AlterationsEpigenetic inactivation of tumor suppressor SFRP2 and point mutation in KRAS proto-oncogene in fistula-associated mucinous type anal adenocarcinoma: report of two cases.20686305
Anal Mucinous AdenocarcinomaEpigenetic AlterationsThe current results showed that the combined effects of somatic mutations in K-ras and epigenetic alterations in SFRP2 genes may play an active role in the development of mucinous type anal adenocarcinoma.20686305
Glioblastoma MultiformeEpigenetic AlterationsEpigenetic silencing of the O(6)-methylguanine-DNA-methyltransferase (MGMT) gene by promoter methylation is correlated with improved progression-free survival (PFS) and overall survival (OS) in adult patients with newly diagnosed glioblastoma multiforme (GBM) who receive alkylating agents.20686820
Neoplasms, Renal Cell Carcinoma Pathway, Hematologic Neoplasms, Prostate Cancer Pathway, AneuploidyEpigenetic AlterationsPeripheral blood lymphocytes of patients with hematological malignancies or solid tumors, such as renal cell carcinoma or prostate cancer, display epigenetic aberrations (loss of synchronous replication of allelic counterparts) and genetic changes (aneuploidy) characteristic of the cancerous phenotype.20689761
Renal Cell CarcinomaEpigenetic AlterationsGenetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas.20693965
Refractory Cytopenia of Childhood, NeoplasmsEpigenetic AlterationsLarge-scale screening of 3p human chromosome genes/loci in RCC and histologically normal tissues surrounding the tumors using NotI-microarray approach demonstrated that NKIRAS1 gene contained the largest percent of genetic/epigenetic changes in RCC tumor cells.20693965
Hypopharyngeal Squamous Cell CarcinomaEpigenetic AlterationsmiR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC).20700123
Pancreatic carcinoma, Primary malignant neoplasmEpigenetic AlterationsMicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion.20703102
Malignant neoplasm of lung, LymphomaEpigenetic AlterationsThe microRNA-17-92 cluster is an oncogene in human B cell lymphomas and lung cancers.20703102
Pancreatic carcinomaEpigenetic AlterationsPrevious microRNA microarray data revealed that miR-17-5p, a member of the miR-17-92 cluster, is upregulated in pancreatic cancer.20703102
Hematopoietic Neoplasms, NeoplasmsEpigenetic AlterationsGTPase regulator associated with the focal adhesion kinase (GRAF), a putative tumor suppressor gene, is found inactivated in hematopoietic malignancies by either genetic or epigenetic abnormalities.20704716
Breast CarcinomaEpigenetic AlterationsEpigenetic silencing of retinoic acid receptor-beta2 (RARbeta2) and estrogen receptor-alpha (ERalpha) expressions have been revealed to be important in the development of approaches for diagnosis and therapy of breast cancer.20711807
NeoplasmsEpigenetic AlterationsTumour suppressor ING4 is one of ING family genes, which are involved in cell cycle arrest, gene transcription regulation, DNA repair and apoptosis.20716169
Prostate Cancer Pathway, Aggressive behaviorEpigenetic AlterationsEpigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior.20717995
Carcinoma of lung, CarcinogenesisEpigenetic AlterationsBased on the important role of microRNA (miRNA) biosynthesis genes in carcinogenesis, we hypothesized that polymorphisms in the miRNA biosynthesis genes may modulate susceptibility to lung cancer.20721975
Hollings Cancer CenterEpigenetic AlterationsFurthermore, we showed that histone modification contributes to leptins gene regulation in HCC.20723213
Stomach CarcinomaEpigenetic AlterationsSystematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression.20726036
Stomach CarcinomaEpigenetic AlterationsGastric cancer shows a complex derangement of the miRNA-ome, including Dicer and Drosha.20726036
Stomach CarcinomaEpigenetic AlterationsTwenty miRNAs were up- and two down-regulated in gastric carcinoma compared with non-neoplastic tissue.20726036
Malignant neoplasm of stomachEpigenetic AlterationsSix of these miRNAs separated node-positive from node-negative gastric cancers, ie miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a.20726036
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsFive miRNAs expressed differentially in node-positive cancers had conserved binding sites for mRNAs differentially expressed in the same set of tumour samples.20726036
Colorectal Cancer PathwayEpigenetic AlterationsmicroRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells.20727858
Primary malignant neoplasmEpigenetic AlterationsDeregulated microRNAs and their roles in cancer development have attracted much attention.20727858
Non-Small Cell Lung CarcinomaEpigenetic AlterationsExpression and function of miRNA in postoperative radiotherapy sensitive and resistant patients of non-small cell lung cancer.20728239
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMoreover, our results showed miRNA-126 promoted non-small cell lung cancer cells apoptosis induced by irradiation through the PI3K-Akt pathway.20728239
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe found 12 differently expressed miRNAs in the radiotherapy sensitive and resistant non-small cell lung cancer samples.20728239
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsHowever, at date the somatic epigenetic events that occur in head and neck squamous cell carcinoma (HNSCC) tumorigenesis are not yet been well defined.20729134
Refractory Cytopenia of ChildhoodEpigenetic AlterationsSeveral SNPs belonging to the pre-miRNA and were identified to be significantly associated with RCC recurrence.20732906
VulvaEpigenetic AlterationsConclusions are as follows: (i) the epigenetic inactivation of genes is a common event in vulvar SCC and is also present in adjacent lesions, implying a possible precursor role for these alterations; (ii) MGMT and RASSF2A hypermethylation are present exclusively in vulvar SCC and LS associated with SCC, and absent from isolated LS; and (iii) TSP-1 hypermethylation is a bad prognosis factor in vulvar SCC.20734389
Malignant neoplasm of urinary bladderEpigenetic AlterationsDNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer.20802236
Primary malignant neoplasmEpigenetic AlterationsDNA methylation profiles can be used to define molecular cancer subtypes that may better inform disease etiology and clinical decision-making.20802236
Malignant neoplasm of urinary bladder, Aggressive behavior, NeoplasmsEpigenetic AlterationsExposures and demographic associated with increased risk of bladder cancer specifically associate with particular subgroups of tumors defined by DNA methylation profiling and these subgroups may define more aggressive disease.20802236
Malignant tumor of colon, NeoplasmsEpigenetic AlterationsEpigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer.20802524
Malignant tumor of colonEpigenetic AlterationsWe aim to clarify the epigenetic inactivation, biological function and clinical significance of TBX5 in colon cancer.20802524
Neoplastic Syndromes, HereditaryEpigenetic AlterationsAn increasing body of evidence points to a possible role of microRNAs (miRNAs) in hereditary cancer syndromes.20810544
Primary malignant neoplasmEpigenetic AlterationsNo allelic variant was detected for hsa-mir-17 and hsa-mir-369, and allelic and genotype frequencies for miR-146a rs2910164 single-nucleotide polymorphism (SNP) were comparable with that of 155 controls from the same population, ruling out a role for genetic variations in these three miRNAs as major determinants in cancer predisposition of BRCA1/BRCA2-negative patients.20810544
Carcinogenesis, Carcinoma, Ovarian EpithelialEpigenetic AlterationsThe aim of this study was to analyze promoter hypermethylation profiles of each subtype of ovarian epithelial cancer (OEC), to improve the understanding of the role of epigenetic silencing in carcinogenesis.20811671
CarcinogenesisEpigenetic AlterationsEpigenetic DNA methylations plays an important role in oral carcinogenesis.20811686
Malignant neoplasm of mouthEpigenetic AlterationsWNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors.20811686
Primary malignant neoplasmEpigenetic AlterationsThis study showed that the methylation is an important epigenetic alteration in oral cancer.20811686
Primary malignant neoplasmEpigenetic AlterationsSFRP-1 was also characterized by a different statistically significant epigenetic behaviour, because of it was demethylated in cancer (p<0.05).20811686
Malignant neoplasm of mouthEpigenetic AlterationsThis study suggests that a cause of catenin delocalization in oral cancer could be due to WNT pathway activation, by epigenetic alterations of SFRP, WIF-1 and DKK-3 genes.20811686
Ulcerative ColitisEpigenetic AlterationsWe hypothesized that differences in circulating immune cells in CD and UC patients are reflected by altered miRNA expression and that miRNA expression patterns can distinguish CD and UC from normal healthy individuals.20812331
Ulcerative ColitisEpigenetic AlterationsTwelve miRNAs were significantly increased and miRNA-505* was significantly decreased in the blood of active UC patients as compared to healthy controls.20812331
Ulcerative ColitisEpigenetic AlterationsTen miRNAs were significantly increased and one miRNA was significantly decreased in the blood of active UC patients as compared to active CD patients.20812331
Ulcerative Colitis, Crohn DiseaseEpigenetic AlterationsPeripheral blood microRNAs distinguish active ulcerative colitis and Crohns disease.20812331
Ulcerative ColitisEpigenetic AlterationsPeripheral blood miRNAs can be used to distinguish active CD and UC from healthy controls.20812331
Ulcerative Colitis, Inflammatory Bowel DiseasesEpigenetic AlterationsThe data support the evidence that CD and UC are associated with different circulating immune cells types and that the differential expression of peripheral blood miRNAs may form the basis of future diagnostic tests for inflammatory bowel disease.20812331
Carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsBMS is an alternative method to detect cancer specific genetic and epigenetic alterations and will be a useful complementary diagnostic tool for lung cancer.20813423
Carcinoma of lungEpigenetic AlterationsInvestigation of genetic and epigenetic changes associated with lung cancer has clinical importance for its diagnosis and management.20813423
PathologyEpigenetic AlterationsSerum microRNA characterization identifies miR-885-5p as a potential marker for detecting liver pathologies.20815808
Hollings Cancer Center, Liver carcinomaEpigenetic AlterationsReal-time qPCR (quantitative PCR)-based TaqMan MicroRNA arrays were first employed to profile miRNAs in serum pools from patients with HCC (hepatocellular carcinoma) or LC (liver cirrhosis) and from healthy controls.20815808
PathologyEpigenetic AlterationsIn summary, miR-885-5p is significantly elevated in the sera of patients with liver pathologies, and our data suggest that serum miRNAs could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.20815808
Malignant neoplasm of breastEpigenetic AlterationsBiologic profiling of lymph node negative breast cancers by means of microRNA expression.20818337
Malignant Neoplasms, Triple-Negative Breast Cancer Finding, NeoplasmsEpigenetic AlterationsOther interesting observations are the presence of several microRNAs (miR532-5p, miR-500, miR362-5p, and miR502-3p) located at Xp11.23 in cancers with a triple-negative signature, and the upregulation of several miR-17 cluster members in estrogen receptor-negative tumors.20818337
NeoplasmsEpigenetic AlterationsGenetic and epigenetic alterations identified in this study are correlated with OT molecular groups we have recently reported: a neurogenic group composed of tumors with loss of heterozygosity (LOH) at 1p-19q, IDH1 mutations, and MGMT promoter methylation, showing good prognosis; an intermediate group, presenting TP53 mutations or LOH at 17p, IDH1 mutations, and GSTP1 promoter methylation; and a proliferative group, presenting major genetic alterations (LOH at 10q, EGFR amplification, and CDKN2A/ARF deletion) and poor prognosis.20820872
Breast CarcinomaEpigenetic AlterationsIn summary, transcriptional changes induced in breast cancer cells by fibroblasts from positive as well as negative nodes are very much alike in a specific lineage.20820980
Malignant neoplasm of urinary bladderEpigenetic AlterationsIntegrated genetic and epigenetic analysis of bladder cancer reveals an additive diagnostic value of FGFR3 mutations and hypermethylation events.20824703
Primary malignant neoplasm, Refractory Cytopenia of ChildhoodEpigenetic AlterationsIn conclusion, our study supports the concept of global histone modification levels as a universal cancer prognosis marker, and provides evidence for the use of histone deacetylases inhibitors as future drugs in the therapy of RCC.20825416
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsRecent studies have suggested that global histone modifications are predictors of cancer recurrence in various tumor entities.20825416
Renal Cell Carcinoma PathwayEpigenetic AlterationsGlobal histone acetylation levels: prognostic relevance in patients with renal cell carcinoma.20825416
Refractory Cytopenia of Childhood, Renal Cell Carcinoma PathwayEpigenetic AlterationsGlobal histone acetylation levels (histone H3 lysine 9 acetylation [H3K9Ac], histone H3 lysine 18 acetylation [H3K18Ac], total histone H3 acetylation [H3Ac] and total histone H4 acetylation [H4Ac]) were determined in patients with renal cell carcinoma (RCC) using immunohistochemistry in a tissue micro array with 193 RCC and 10 oncocytoma specimens.20825416
Refractory Cytopenia of ChildhoodEpigenetic AlterationsThe histone acetylation pattern was not different among the diverse histological subtypes of RCC or oncocytoma samples.20825416
CarcinogenesisEpigenetic AlterationsEpigenetic alterations play an important role in carcinogenesis.20825416
melanoma, NeoplasmsEpigenetic AlterationsMelanoma cells were harvested from primary, cutaneous MM tumors by laser-capture microdissection, and microRNA expression profiles were obtained by the microarray technique.20827223
Aortic Aneurysm, Thoracic, Muscle, Smooth, Vascular, Marfan SyndromeEpigenetic AlterationsEpigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms.20829218
Aortic Aneurysm, ThoracicEpigenetic AlterationsOur results demonstrate the heritability, the cell specificity, and the independence with regard to TGF-b1 and genetic backgrounds of the Smad2 dysregulation in human thoracic aneurysms and the involvement of epigenetic mechanisms regulating histone marks in this process.20829218
High-Frequency Microsatellite Instability, Stomach Carcinoma, Low-Frequency Microsatellite InstabilityEpigenetic AlterationsWe demonstrated for the first time that MSI-H can develop from MSI-L or the absence of MSI due to time-dependent accumulation of DNA methylation during progression of early-stage gastric carcinomas.20831982
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsDNA methylation in patients with colorectal cancer--correlation with some clinical and morphological features and with local tumour invasion.20836393
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are a family of small, non-coding RNA species functioning as negative regulators of multiple target genes including tumour suppressor genes and oncogenes.20838434
Squamous cell carcinoma of lungEpigenetic AlterationsMicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma.20838434
Carcinoma of lung, NeoplasmsEpigenetic AlterationsTo identify potential new amplified oncogenic and/or deleted tumour suppressing miRNAs in lung cancer, we inferred miRNA gene dosage from high dimensional arrayCGH data.20838434
Carcinoma of lungEpigenetic AlterationsAnalysis of three independent published lung cancer arrayCGH datasets confirmed that 22 of these miRNA loci showed directionally concordant copy number variation.20838434
Carcinoma of lung, NeoplasmsEpigenetic AlterationsThus, we show for the first time that putative lung cancer-associated miRNAs can be identified from genome-wide arrayCGH datasets using a bioinformatics mapping approach, and report that miR-218 is a strong candidate tumour suppressing miRNA potentially involved in lung cancer.20838434
Rheumatoid ArthritisEpigenetic AlterationsMicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients.20840794
Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsWe conclude that in older CN-AML patients, low BAALC and ERG expression associates with better outcome and distinct gene and microRNA expression signatures that could aid in identifying new targets and novel therapeutic strategies for older patients.20841507
Tumor Hypoxia, NeoplasmsEpigenetic AlterationsLoss of Beclin 1 expression (allelic loss or microRNA regulatory activity, as suggested in the literature) defines poor prognosis presumably by promoting anti-apoptotic pathways, while overexpression of the protein, being linked with tumour hypoxia and acidity, also defines subgroups of tumours with aggressive clinical behaviour.20842118
Leukemia, Myelomonocytic, Chronic, Myeloid Leukemia, ChronicEpigenetic AlterationsExpression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemia.20842500
Lesion of breastEpigenetic AlterationsPreviously, we reported that the accuracy of cytological diagnosis of breast lesions could be augmented through the quantitative assessment of DNA methylation of fine-needle aspirate (FNA) washings.20842524
Breast CarcinomaEpigenetic AlterationsThus, epigenetic biomarkers provide valuable tools for breast cancer patient management.20842524
Malignant neoplasm of urinary bladderEpigenetic AlterationsFunctional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer.20843712
Malignant neoplasm of urinary bladder, Best Case Imputation TechniqueEpigenetic AlterationsOur previous study demonstrated that fascin homolog 1 (FSCN1) might have an oncogenic function in bladder cancer (BC) and that its expression was regulated by specific microRNAs (miRNAs).20843712
NeoplasmsEpigenetic AlterationsOur data indicate that LASP1 may have an oncogenic function and that it might be regulated by miR-1, miR-133a, and miR-218, which may function as tumor suppressive miRNAs in BC.20843712
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsThe main epigenetic modification in glioma is aberrant DNA methylation that is now renowned to be a common hallmark of brain tumors.20844987
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsEpigenetic inactivation of HOXA5 and MSH2 gene in clear cell renal cell carcinoma.20846263
Primary malignant neoplasmEpigenetic AlterationsThe study provides further evidence in support of the notion that epigenetic regulation of let-7a-3 may affect the actions of IGFs in cancer.20848182
Nasopharyngeal carcinomaEpigenetic AlterationsFrequent epigenetic inactivation of Myocardin in human nasopharyngeal carcinoma.20848417
Nasopharyngeal carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumor suppressor genes plays an important role in nasopharyngeal carcinoma (NPC) tumorigenesis.20848417
Chronic inflammatory disorder, Ulcerative ColitisEpigenetic AlterationsMicroRNAs (miRNAs) are small, noncoding RNAs that act as potent negative regulators of gene expression and are differentially expressed in chronic inflammatory diseases, including UC.20848482
Crohns disease of large bowelEpigenetic AlterationsIdentification of microRNAs associated with ileal and colonic Crohns disease.20848482
ibudilast, Inflammatory Bowel DiseasesEpigenetic AlterationsThe expression differences between ileal CD, colonic CD, and previously identified UC-associated miRNAs support the likelihood that miRNAs influence differing inflammation-related gene expression in each inflammatory bowel disease (IBD) subtype and may form the basis for future diagnostic tests and therapeutic targets for IBD.20848482
Ulcerative ColitisEpigenetic AlterationsSerological and epigenetic markers identify a subset of UC patients with an expression profile of a key TH1 pathogenic cytokine.20848535
Carcinogenesis, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsChanges in DNA methylation of crucial cancer genes including tumor suppressors can occur early in carcinogenesis, being potentially important early indicators of cancer.20849603
Malignant NeoplasmsEpigenetic AlterationsThe miR-17-92 gene cluster, a polycistron encoding six microRNAs (miRNA), is frequently overexpressed in human cancers and has been shown to promote several aspects of oncogenic transformation, including evasion of apoptosis.20851997
Adenoma of large intestine, Hyperplastic PolypEpigenetic AlterationsFurthermore, DNA methylation analysis revealed that the frequency of SHH methylation in CRCs (20.6%) was significantly lower than that in colorectal adenomas (72.4%, p<0.001) and hyperplastic polyps (64.7%, p = 0.002).20854074
Primary malignant neoplasmEpigenetic AlterationsDNA methylation patterns are frequently dysregulated in cancer, although little is known of the mechanisms through which specific gene sets become aberrantly methylated.20855866
MICROPHTHALMIA, SYNDROMIC 7, Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe find that the promoter DNA methylation signature of EVI1 AML blast cells differs from those of normal CD34(+) bone marrow cells and other AMLs.20855866
MICROPHTHALMIA, SYNDROMIC 7Epigenetic AlterationsOur data point to a role for EVI1 in directing aberrant promoter DNA methylation patterning in EVI1 AMLs.20855866
Multiple Myeloma, Primary malignant neoplasmEpigenetic AlterationsEpigenetic dysregulation is a hallmark of cancer, including multiple myeloma.20862746
Prostate Cancer PathwayEpigenetic Alterations[Expressions of 6 microRNAs in prostate cancer].20873592
Malignant NeoplasmsEpigenetic AlterationsExperimental evidence shows that microRNAs play an important role in the initiation and progression of human malignancies.20873592
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThen we analyzed the correlation among the expressions of the 6 microRNAs in PCa and their correlation with the Gleason score and clinical stages of PCa.20873592
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer.20873592
OsteosarcomaEpigenetic AlterationsmicroRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2.20878132
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsCirculating miRNAs exist in serum and plasma and they can be used as a potential noninvasive molecular marker for colorectal cancer (CRC) diagnosis.20880178
cervical cancer, Federation of Gynecology and ObstetricsEpigenetic AlterationsEpigenetic therapy and cisplatin chemoradiation in FIGO stage IIIB cervical cancer.20882878
Liver carcinomaEpigenetic AlterationsEfficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers.20883676
Malignant NeoplasmsEpigenetic AlterationsDNA methylation is an epigenetic modification that is profoundly altered in most cancers.20885350
Acute myocardial infarctionEpigenetic AlterationsMicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction.20886220
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsLoss of the PTEN tumor suppressor gene occurs frequently in non-small-cell lung carcinoma (NSCLC), although neither genetic alterations nor epigenetic silencing are significant predictors of PTEN protein levels.20889565
Prostate Cancer PathwayEpigenetic AlterationsSuitable reference genes for relative quantification of miRNA expression in prostate cancer.20890088
Prostate Cancer PathwayEpigenetic AlterationsCurrently, no validated reference genes for miRNA qPCR in prostate cancer are available.20890088
Fibrosis, LiverEpigenetic AlterationsMicro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis.20890893
HepatocarcinogenesisEpigenetic AlterationsRecently, miRNAs have been suggested to crucially modulate cellular processes in the liver such as hepatocarcinogenesis.20890893
Breast CarcinomaEpigenetic AlterationsDNA methylation epigenotypes in breast cancer molecular subtypes.20920229
Breast CarcinomaEpigenetic AlterationsOur results provide evidence that well defined DNA methylation profiles enables breast cancer subtype prediction and support the utilization of this biomarker for prognostication and therapeutic stratification of patients with breast cancer.20920229
Breast CarcinomaEpigenetic AlterationsGenetic mutations along with epigenetic alterations contribute to gene expression changes occurring in breast cancer.20920229
Breast CarcinomaEpigenetic AlterationsSo far, these epigenetic contributions to sporadic breast cancer subtypes have not been well characterized, and there is only a limited understanding of the epigenetic mechanisms affected in those particular breast cancer subtypes.20920229
Malignant neoplasm of thyroidEpigenetic AlterationsFrequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences.20920251
Malignant Neoplasms, Breast CarcinomaEpigenetic AlterationsAlteration of DNA methylation is an epigenetic change in human cancers, including breast cancer.20920981
Myocardium, Cardiovascular DiseasesEpigenetic AlterationsCirculating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease.20921333
PathologyEpigenetic AlterationsSmall RNA molecules, called microRNAs, freely circulate in human plasma and correlate with varying pathologies.20921333
Viral myocarditisEpigenetic AlterationsIn viral myocarditis, we observed a milder but significant elevation of these microRNAs, 30-fold and 6-fold, respectively.20921333
DamageEpigenetic AlterationsCardiac damage initiates the detectable release of cardiomyocyte-specific microRNAs-208b and -499 into the circulation.20921333
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsWe used the techniques of quantitative real-time PCR and DNA methylation-specific PCR combined microdissection to precisely detect MUC4 expression and promoter methylation status in 116 microdissected foci from 57 patients with pancreatic ductal adenocarcinoma.20922503
SF3B1 wt AlleleEpigenetic AlterationsPromoter hypermethylation of the NPM1 gene may lead to suppressed gene transcription and hence functional haploinsufficiency, which contributes to the development of MDS.20924036
Carcinoma of lungEpigenetic AlterationsOur approach was to screen for lung cancer by assessing the cheek cells based on emerging genetic/epigenetic data which suggests that the buccal epithelium is altered in lung field carcinogenesis.20924114
Glioma, Glioblastoma Multiforme PathwayEpigenetic AlterationsA study of paired initial and recurrent gliomas demonstrated that methylation profiles were remarkably stable across glioma evolution, even during anaplastic transformation, suggesting that epigenetic alterations occur early during gliomagenesis.20926426
Malignant neoplasm of larynxEpigenetic AlterationsThe chondroitin/dermatan sulfate synthesizing and modifying enzymes in laryngeal cancer: expressional and epigenetic studies.20929582
Adult Burkitt LymphomaEpigenetic AlterationsAlteration of microRNAs regulated by c-Myc in Burkitt lymphoma.20930934
cervical cancerEpigenetic AlterationsThe reversing of epigenetic aberrations using the inhibitors of DNA methylation and histone deacetylases may have therapeutic value in cervical cancer.20931299
Admitting diagnosisEpigenetic AlterationsThese data support the hypothesis that patterns of miRNA expression in cortical GM may contribute to AD pathogenetically, because the aggregate change in miRNA expression observed early in the disease would be predicted to cause profound changes in gene expression.20936480
Primary malignant neoplasmEpigenetic AlterationsInteraction between the MTHFR C677T polymorphism and alcohol--impact on oral cancer risk and multiple DNA methylation of tumor-related genes.20940365
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs), which are endogenously expressed regulatory noncoding RNAs, have an altered expression in tumor tissues.20944140
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe evaluation of miRNA expression could yield new information about PCa pathogenesis.20944140
Adenocarcinoma Of EsophagusEpigenetic AlterationsInflammatory and microRNA gene expression as prognostic classifier of Barretts-associated esophageal adenocarcinoma.20947516
Ovarian Carcinoma, Glioblastoma MultiformeEpigenetic AlterationsPresence of microRNAS produced by malignant cells has been reported in the blood and saliva of tumor-bearing patients, especially patients diagnosed with glioblastoma or ovarian carcinoma.20950422
Nasopharyngeal carcinomaEpigenetic AlterationsExtra-cellular release and blood diffusion of BART viral micro-RNAs produced by EBV-infected nasopharyngeal carcinoma cells.20950422
Infection caused by Helicobacter pylori, Stomach CarcinomaEpigenetic AlterationsMTHFR C677T and Helicobacter pylori infection are believed to play critical roles in the DNA methylation process, an epigenetic feature frequently found in gastric cancer.20957490
Communicable Diseases, NeoplasmsEpigenetic AlterationsDNA methylation in CDKN2A associated to the MTHFR 677T carrier is suggested to be a distal tumor characteristic, especially in those 60 years old or older, and it seems to depend on the infection by H. pylori cagA/vacAs1m1 strains.20957490
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA expression profiling of exfoliated colonocytes isolated from feces for colorectal cancer screening.20959518
Clinical CoordinatorEpigenetic AlterationsExpression analysis of oncogenic microRNA (miRNA) in peripheral blood was recently reported for CRC detection.20959518
Clinical CoordinatorEpigenetic AlterationsThe exfoliated colonocytes of 197 CRC patients and 119 healthy volunteers were analyzed because of the presence of sufficient miRNA concentration.20959518
Clinical CoordinatorEpigenetic AlterationsmiRNA was relatively well conserved in exfoliated colonocytes from feces both of CRC patients and healthy volunteers.20959518
Clinical CoordinatorEpigenetic AlterationsmiRNA expression analysis of the isolated colonocytes may be a useful method for CRC screening.20959518
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsDietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC).20960050
Colorectal Cancer PathwayEpigenetic AlterationsDietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.20960050
ACTH-Producing Pituitary Gland Neoplasm, Pituitary carcinomaEpigenetic AlterationsMicroRNA expression in ACTH-producing pituitary tumors: up-regulation of microRNA-122 and -493 in pituitary carcinomas.20960104
Adenoma, Pituitary carcinomaEpigenetic AlterationsBoth real-time RT-PCR and in situ hybridization showed significant up-regulation of miRNA-122 between pituitary carcinomas and adenomas.20960104
Carcinoma, AdenomaEpigenetic AlterationsMiRNA-493 was also up-regulated in carcinomas compared to ACTH adenomas.20960104
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are involved in cell proliferation, differentiation, and apoptosis, and can function as tumor suppressor genes or oncogenes.20960104
Carcinoma, AdenomaEpigenetic AlterationsThere were more miRNAs up- (188) or down-regulated (160) between adenomas and normal pituitaries compared to carcinomas and normal pituitaries (92 up- and 91 down-regulated) or between carcinomas and adenomas (46 up- and 52 down-regulated).20960104
Pituitary NeoplasmsEpigenetic AlterationsThese results provide information about marker miRNAs that may lead to further insights into the regulation of pituitary tumor growth and development.20960104
Malignant neoplasm of kidney, Conventional (Clear Cell) Renal Cell Carcinoma, Refractory Cytopenia of Childhood, NeoplasmsEpigenetic AlterationsThe commonest histological type of renal cancer, clear cell renal cell carcinoma (cc RCC), is associated with genetic and epigenetic changes in the von Hippel-Lindau (VHL) tumour suppressor.20964835
Malignant neoplasm of kidneyEpigenetic AlterationsThe VHL-dependent regulation of microRNAs in renal cancer.20964835
NeoplasmsEpigenetic AlterationsDifferential levels of specific microRNAs (miRNAs) are observed in several tumours when compared to normal tissue.20964835
Malignant neoplasm of kidneyEpigenetic AlterationsThis pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue.20964835
Carcinogenesis, ovarian neoplasmEpigenetic AlterationsDistinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis.20965493
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsThe Illumina beads array (Illumina Inc, San Diego, CA) was used to profile DNA methylation in enriched tumor cells that had been isolated from 75 benign and malignant serous tumor tissues and 6 tumor-associated stromal cell cultures.20965493
Colorectal Cancer PathwayEpigenetic AlterationsSpecific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.20967208
Clinical CoordinatorEpigenetic AlterationsLogistic regression was used to test for association between SNPs in the region of MLH1 and CRC, MSI-H CRC, MLH1 gene expression in CRC, and DNA methylation in CRC.20967208
Carcinogenesis, SERPINB3 wt AlleleEpigenetic AlterationsThis study showed that IAP expression is an early event in oral carcinogenesis and that epigenetic and genetic pathways are associated with IAP expression in OSCC.20967871
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) regulate hundreds of genes central to maintaining a cancer phenotype.20975375
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsWe measured expression of these miRNAs in formalin-fixed, paraffin-embedded tissue from both tumor and matched normal lung in a set of 46 patients with surgically resected T1 or T2 stage I NSCLC.20975375
Gastrointestinal Stromal TumorsEpigenetic AlterationsThe vast majority of GISTs exhibit activating mutations of KIT or PDGFRA, but epigenetic alteration of GISTs is largely unknown.20978145
Glioblastoma Multiforme PathwayEpigenetic AlterationsGlobal histone modification patterns as prognostic markers to classify glioma patients.20978174
NeoplasmsEpigenetic AlterationsRPA classified the patients into 10 distinct prognostic groups based on WHO grade, histology, and histone modifications: H3K9Ac (<88% or >=88% tumor cells), H3K4diMe (<64% or >=64% tumor cells), H3K18Ac (<74% or >=74% tumor cells), and H4K20triMe (<75% or >=75% tumor cells).20978174
Glioblastoma Multiforme PathwayEpigenetic AlterationsMultiple histone modifications seem to have prognostic relevance in glioma.20978174
NeoplasmsEpigenetic AlterationsAn altered pattern of epigenetic modifications is central to the development and progression of various tumors.20978174
Malignant neoplasm of lungEpigenetic AlterationsMicroRNAs (miRNA) mediate distinct gene regulatory pathways triggered by epidermal growth factor receptor (EGFR) activation, which occurs commonly in lung cancers with poor prognosis.20978205
Carcinoma of lungEpigenetic AlterationsIn this study, we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic "oncomiR" and its role as a key mediator of EGFR signaling in lung cancer cells.20978205
InflammationEpigenetic AlterationsInsufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation.20980348
InflammationEpigenetic AlterationsChronic inflammation is deeply involved in induction of aberrant DNA methylation, but it is unclear whether any type of persistent inflammation can induce methylation and how induction of cell proliferation is involved.20980348
Leukemia, Myelocytic, AcuteEpigenetic AlterationsUsing microRNA microarrays, we characterized the microRNA gene expression of 27 patients with acute myeloid leukemia (AML) with normal cytogenetics, focusing on the microRNAs differentially expressed between the M1 and M5 French-American-British (FAB) subtypes.20981674
Leukemia, Myelocytic, AcuteEpigenetic AlterationsExpression profiling of cytogenetically normal acute myeloid leukemia identifies microRNAs that target genes involved in monocytic differentiation.20981674
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAn accurate delineation of these two AML entities was observed based on the expression of 12 microRNAs.20981674
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe expression changes of the candidate microRNAs during monocytic differentiation of AML cell lines treated with Vitamin D and phorbol 12-myristate 13-acetate were examined.20981674
Pleural Effusion, MalignantEpigenetic AlterationsWe compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively).21029414
Primary malignant neoplasmEpigenetic AlterationsCirculating cell-free microRNAs have been identified as potential cancer biomarkers.21029414
Pleural Effusion, Malignant, NeoplasmsEpigenetic AlterationsCell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.21029414
effusionEpigenetic AlterationsWe measured the expression of 22 miRNAs using qRT-PCR in two samples, which were pooled with 18 malignant and 12 benign effusions, respectively.21029414
effusion, Malignant NeoplasmsEpigenetic AlterationsCollectively, our study demonstrated that cell-free miRNAs in the supernatant of effusions may aid in the diagnosis of malignancy and predict chemosensitivity to docetaxel.21029414
Endometrial Endometrioid AdenocarcinomaEpigenetic AlterationsThe expression of the miRNA-200 family in endometrial endometrioid carcinoma.21035172
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsRecent reports suggest that targeting the unique miRNAs highly expressed in several cancers may be a promising approach in the development of new cancer therapeutic tools.21035172
Chronic Obstructive Airway DiseaseEpigenetic AlterationsMicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease.21037022
Chronic Obstructive Airway DiseaseEpigenetic AlterationsEight miRNAs were expressed at a significantly lower level in current-smoking patients with COPD compared with never-smokers without airflow limitation.21037022
Breast CarcinomaEpigenetic AlterationsLoss of heterozygosity and DNA methylation affect germline fibroblast growth factor receptor 4 polymorphism to direct allelic selection in breast cancer.21037081
Breast CarcinomaEpigenetic AlterationsThese findings support a growth advantage function for FGFR4-R388 and underscore the complex role of DNA methylation and LOH in determining the penetrance of allelic selection in breast cancer progression.21037081
Malignant NeoplasmsEpigenetic AlterationsUsing a database of 861 colon and rectal cancers, DNA methylation at 16 CpG islands [CACNA1G, CDKN2A (p16/ink4a), CHFR, CRABP1, HIC1, IGF2, IGFBP3, MGMT, MINT-1, MINT-31, MLH1, NEUROG1, p14 (CDKN2A/arf), RUNX3, SOCS1, and WRN] was quantified by real-time PCR.21037082
Acute leukemiaEpigenetic AlterationsExpression of IGFBP7 in acute leukemia is regulated by DNA methylation.21040219
Acute leukemiaEpigenetic AlterationsIn conclusion, aberrant IGFBP7 expression is regulated by DNA methylation in acute leukemia.21040219
Metastasis, Squamous cell carcinoma of esophagusEpigenetic AlterationsIdentification and validation of DNA methylation markers to predict lymph node metastasis of esophageal squamous cell carcinomas.21042947
Carcinoma of lungEpigenetic AlterationsSHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates.21047392
ovarian neoplasmEpigenetic AlterationsIn addition, we have established the clinical relevance of these microRNAs for ovarian cancer patients treatment response and survival.21051560
Ovarian CarcinomaEpigenetic AlterationsFurthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients.21051560
Malignant neoplasm of ovaryEpigenetic AlterationsDistinctive DNA methylation patterns of cell-free plasma DNA in women with malignant ovarian tumors.21056906
Liver carcinomaEpigenetic AlterationsFrequent and distinct aberrations of DNA methylation patterns in fibrolamellar carcinoma of the liver.21060828
Liver carcinoma, Hepatocellular Adenoma, Hollings Cancer CenterEpigenetic AlterationsGene silencing due to aberrant DNA methylation is a frequent event in hepatocellular carcinoma (HCC) and also in hepatocellular adenoma (HCA).21060828
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsIn contrast to common HCC the APC and CDH1 (E-cadherin) genes were found devoid of any DNA methylation in FLC, whereas the GSTp1 gene showed comparable DNA methylation in tumor and surrounding tissue at a moderate level.21060828
Malignant NeoplasmsEpigenetic AlterationsFLCs display frequent and distinct gene-specific hypermethylation in the absence of significant global hypomethylation indicating that these two epigenetic aberrations are induced by different pathways and that full-blown malignancy can develop in the absence of global loss of DNA methylation.21060828
Liver carcinoma, Fibrolamellar Hepatocellular CarcinomaEpigenetic AlterationsHowever, very little is known about epigenetic defects in fibrolamellar carcinoma (FLC), a rare variant of hepatocellular carcinoma that displays distinct clinical and morphological features.21060828
Hodgkin DiseaseEpigenetic AlterationsThese findings support the notion that epigenetic-interactions between these cytokines may influence pathogenesis of HD modulating the proliferation of regulatory T cells.21061265
heterochromatin organization, Chronic Lymphocytic LeukemiaEpigenetic AlterationsConcomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males.21062507
Chronic Lymphocytic LeukemiaEpigenetic AlterationsIncrease in acetyl-H3 in resistant female but not male CLL samples as well as a decrease of total cellular level of RelB after an inhibition of histone deacetylase (HDAC) by trichostatin A (TSA), further emphasize the role of epigenetic modifications which could discriminate two CLL subsets.21062507
Choline Dehydrogenase, MitochondrialEpigenetic AlterationsOur observations promote the concept that epigenetic processes are under genetic control and that, other than environment, variation in genes encoding KATs may also determine susceptibility to CHD outcomes and mortality.21062767
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsHypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer.21062931
Pituitary AdenomaEpigenetic AlterationsMicroRNA profile indicates downregulation of the TGFb pathway in sporadic non-functioning pituitary adenomas.21063788
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small, non-coding RNAs of endogenous origin, they have been increasingly shown to have aberrant expression in many tumor types.21063914
Colorectal NeoplasmsEpigenetic AlterationsSequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression.21068132
Colorectal NeoplasmsEpigenetic AlterationsHierarchical epigenetic alterations occur at transition points during colorectal neoplastic progression.21068132
Pancreatic Ductal Adenocarcinoma, PancreatitisEpigenetic AlterationsThe same results were obtained in the expression levels of microRNA-155 in tissue and pancreatic juice between pancreatic ductal adenocarcinoma and chronic pancreatitis (P=0.014 and P=0.021, respectively).21068491
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsMicroRNA-21 and microRNA-155 in pancreatic juice have the potential of becoming biomarkers for diagnosing pancreatic ductal adenocarcinoma.21068491
malignant disease, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsMicroRNAs are small RNAs regulating various cellular processes and have recently been identified as possible markers of malignant diseases including pancreatic ductal adenocarcinoma.21068491
Malignant tumor of colon, Colorectal CarcinomaEpigenetic AlterationsHigh levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients.21069438
Malignant tumor of colon, Primary malignant neoplasmEpigenetic AlterationsMicroRNA-21 (miR-21) is upregulated in several cancer types and has been associated with survival in colon cancer.21069438
Malignant tumor of colonEpigenetic AlterationsWe conclude that miR-21 is primarily a stromal microRNA, which when measured by image analysis identifies a subgroup of stage II colon cancer patients with short disease-free survival.21069438
Hepatitis B, ChronicEpigenetic AlterationsDifferential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha.21070682
Hepatitis CEpigenetic AlterationsThere have been reports of in-vitro interferon (IFN)-mediated antiviral activity against the hepatitis C virus (HCV) through microRNAs (miRNAs).21070682
Virus Diseases, Hepatitis CEpigenetic AlterationsGiven the importance of miRNAs in defending the host against virus infections, it is possible that IFN-induced miRNAs may represent an important determinant of the clinical outcome of IFN therapy in HCV infection.21070682
Malignant NeoplasmsEpigenetic AlterationsCommon single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human cancers.21073609
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe epigenetic disturbances are recognized as an alternative mechanism contributing to the pathogenesis of acute myeloid leukemia (AML).21074269
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDown-regulation of microRNAs 222/221 in acute myelogenous leukemia with deranged core-binding factor subunits.21076613
Myeloid neoplasmEpigenetic AlterationsEpigenetic changes play a role in the pathogenesis of myeloid malignancies, and hypomethylating agents have shown efficacy in these diseases.21077739
Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsTo our knowledge, we provide the first evidence that the expression of a single microRNA, miR-181a, is associated with clinical outcome of patients with CN-AML and may refine their molecular risk classification.21079133
ovarian neoplasmEpigenetic AlterationsThe pathological and clinical significance of aberrant miRNA expression in ovarian tumours has yet to be adequately documented.21083603
ovarian neoplasmEpigenetic AlterationsThe miRNA expression profiles of 103 human ovarian tumours were evaluated.21083603
Malignant Neoplasms, ovarian neoplasmEpigenetic AlterationsVia a bead-based miRNA microarray, five aberrant miRNAs were selected which were expressed differentially in malignant serous tumours from borderline and benign ovarian tumours, including miRNA (miR)-519a, miR-18b (up-regulation) and miR-153, miR-511 and miR-485-5p (down-regulation).21083603
ovarian neoplasmEpigenetic AlterationsWe conducted quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) in order to confirm that these miRNAs are differentially expressed in different histological subtypes of ovarian tumours, and compared the expression profiles of these miRNAs between different clinical subsets.21083603
Malignant neoplasm of ovaryEpigenetic AlterationsA significant correlation was detected between the deregulation of specific types of miRNAs, such as miR-519a, miR-153 and miR-485-5p, and clinical variables as well as histological subtypes in ovarian cancers.21083603
ovarian neoplasmEpigenetic AlterationsAn illegitimate microRNA target site within the 3 UTR of MDM4 affects ovarian cancer progression and chemosensitivity.21084273
NeoplasmsEpigenetic AlterationsWe identified an SNP (SNP34091) in the 3-UTR of MDM4 that creates a putative target site for hsa-miR-191, a microRNA that is highly expressed in normal and tumor tissues.21084273
Increase, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsKnockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma.21088996
Pancreatic carcinomaEpigenetic AlterationsmiRNA expression profiles may be used as biomarkers for detecting pancreatic cancer.21088996
Malignant Neoplasms, Breast CarcinomaEpigenetic AlterationsSporadic breast cancer like many other cancers is proposed to be a manifestation of abnormal genetic and epigenetic changes.21092294
NeoplasmsEpigenetic AlterationsProgressive epigenetic alterations in advancing tumors result in aberrant DDR-apoptotic pathway thereby promoting tumor development.21092294
Glioblastoma MultiformeEpigenetic AlterationsEpigenetic silencing of the MGMT gene by promoter methylation blunts repair of O6-methyl guanine and has been shown to be a predictive factor for benefit from alkylating agent therapy in glioblastoma.21097691
Carcinoma of lungEpigenetic AlterationsGenetic and epigenetic analysis of erbB signaling pathway genes in lung cancer.21102258
Squamous cell carcinoma, Adenocarcinoma, Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe tested three key genetic and epigenetic alterations (EGFR, RASSF1A, and BRAF) of this pathway on a series of primary NSCLC (total 111; adenocarcinoma 49, squamous cell carcinoma [SCC] 48, and others 14).21102258
AdenocarcinomaEpigenetic AlterationsOverall, genetic and/or epigenetic alterations of erbB pathway genes were detected in 80% (39/49) of adenocarcinomas.Approximately half of primary adenocarcinoma harbor molecular alterations of the erbB pathway.21102258
Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic silencing of cancer-related genes by promoter methylation is a frequent event in sporadic colorectal cancer.21102416
CpG Island Methylator Phenotype, Colorectal Cancer PathwayEpigenetic AlterationsThe CpG island methylator phenotype (CIMP+), in which discrete genes throughout the genome are simultaneously methylated, and long-range epigenetic silencing, whereby multiple genes within contiguous chromosomal regions are methylated, have been described in subsets of colorectal cancer.21102416
CpG Island Methylator PhenotypeEpigenetic AlterationsThese findings show that long-range epigenetic silencing across 3p22 occurs in the context of CIMP+ and the BRAF V600E mutation, and only gives rise to microsatellite instability when this process encompasses MLH1.21102416
CpG Island Methylator PhenotypeEpigenetic AlterationsFurthermore, the strong relationship between long-range epigenetic silencing of 3p22 and CIMP+ provides further evidence that these two purportedly distinct epigenetic phenotypes represent a single entity with a common aetiology.21102416
NeoplasmsEpigenetic AlterationsLow-level methylation of MLH1 and flanking 3p22 genes, as well as the BRAF V600E mutation, were detected in the apparently normal colonic mucosa of a small number of cases whose tumours showed a similar molecular profile, suggesting that these concurring genetic and epigenetic events can occur as a field defect in neoplastic development.21102416
CarcinogenesisEpigenetic AlterationsAltered DNA methylation is often seen in malignant cells, potentially contributing to carcinogenesis by suppressing gene expression.21105050
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations in the pattern of DNA and histone modifications play a crucial role in cancer development.21106756
SF3B1 wt Allele, Leukemia, Myelocytic, AcuteEpigenetic AlterationsPhosphoinositide-phospholipase C (PI-PLC) b1 is involved in both genetic and epigenetic mechanisms of MDS progression to acute myeloid leukemia.21109771
Primary malignant neoplasmEpigenetic AlterationsWith the use of a linear regression model we could adjust for the storage-dependent effect, leading to the identification of 54 differentially expressed miRNAs in tongue cancer, compared to 16 when using standard normalization, including up-regulation of a novel miRNA, miR-424.21109926
Breast Cancer Cell, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides that can function as oncogenes or tumor suppressors in human cancer.21109942
Malignant Neoplasms, Cell Proliferation, NeoplasmsEpigenetic AlterationsDown-regulation of the miRNA miR-133a in many type of cancers, and a reduction of cell proliferation, migration, and invasion upon over-expression, suggests that miR-133a is a tumor suppressor.21109942
NeoplasmsEpigenetic AlterationsThe identification of tumor suppressive miRNAs and their target genes could provide new insights into potential mechanism of HNSCC carcinogenesis.21109942
Primary malignant neoplasmEpigenetic AlterationsPromoter-specific expression is regulated by DNA methylation, which is often dysregulated in cancer.21109978
ovarian neoplasmEpigenetic AlterationsThe study suggests that DNA methylation regulates IGF-II promoter-specific expression in ovarian cancer and the regulation may play a role in disease progression.21109978
Malignant NeoplasmsEpigenetic AlterationsIn MNU-induced advanced cancers, DNA methylation at the Tff1 promoter was observed.21111741
CarcinogenesisEpigenetic AlterationsInhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.21111741
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations have been correlated with field cancerization in human patients, but evidence from experimental models that specific epigenetic changes can initiate cancer has been lacking.21111741
NeoplasmsEpigenetic AlterationsEpigenetic alterations of the trefoil factor 1 (TFF1) tumor suppressor gene were evaluated in vitro and in vivo.21111741
Hypergastrinemia (finding), NeoplasmsEpigenetic AlterationsHypergastrinemia suppressed MNU-dependent tumor initiation and progression in a manner that correlated with gene silencing and epigenetic alterations of Tff1.21111741
Stomach CarcinomaEpigenetic AlterationsIn gastric cancer cells, gastrin stimulation partially reversed the epigenetic silencing in the TFF1 promoter.21111741
Stomach CarcinomaEpigenetic AlterationsInitiation of antral gastric cancer is associated with progressive epigenetic silencing of TFF1, which can be suppressed by the hormone gastrin.21111741
Hollings Cancer CenterEpigenetic AlterationsSubsequent differential microRNA expression profiling of CD133(+) and CD133- cells from human HCC clinical specimens and cell lines identified an overexpression of miR-130b in CD133(+) TICs.21112564
Aneuploidy, NeoplasmsEpigenetic AlterationsAmong paired samples, the highest frequencies of DNA methylation were found in tumours with aneuploidy.21115918
NeoplasmsEpigenetic AlterationsThe altered miRNA expressions were reproducibly confirmed in the tumor tissues.21116241
Non-Small Cell Lung CarcinomaEpigenetic AlterationsA logistic regression model with the best prediction was defined on the basis of the four genes (miRNA-21, -126, -210, and 486-5p), yielding 86.22% sensitivity and 96.55% specificity in distinguishing NSCLC patients from the healthy controls.21116241
Non-Small Cell Lung CarcinomaEpigenetic AlterationsPlasma microRNAs as potential biomarkers for non-small-cell lung cancer.21116241
Primary Neoplasm, Non-Small Cell Lung CarcinomaEpigenetic AlterationsUsing microarray platforms, we previously identified 12 microRNAs (miRNAs) the aberrant expressions of which in primary lung tumors are associated with early-stage NSCLC.21116241
Lung Neoplasms, Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe initially validated expressions of the miRNAs in paired lung tumor tissues and plasma specimens from 28 stage I NSCLC patients by real-time quantitative reverse transcription PCR, and then evaluated diagnostic value of the plasma miRNAs in a cohort of 58 NSCLC patients and 29 healthy individuals.21116241
NeoplasmsEpigenetic AlterationsOf the 12 miRNAs, five displayed significant concordance of the expression levels in plasma and the corresponding tumor tissues (all r>0.850, all P<0.05).21116241
Non-Small Cell Lung CarcinomaEpigenetic AlterationsFurthermore, the panel of miRNAs produced 73.33% sensitivity and 96.55% specificity in identifying stage I NSCLC patients.21116241
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAltered expressions of the miRNAs in plasma would provide potential blood-based biomarkers for NSCLC.21116241
NeoplasmsEpigenetic AlterationsThese results identify a role for Sp100 as a tumor suppressor in addition to its role in maintaining ND10/PML bodies and in the epigenetic regulation of gene expression.21118961
ovarian neoplasmEpigenetic AlterationsTaken together, miRNA-related genetic polymorphisms may impact ovarian cancer predisposition and clinical outcome both individually and jointly.21118967
Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsAfter selecting 15 CpG island loci showing breast cancer-specific DNA methylation, another set of normal breast tissue (n = 10), ADH/FEA (n = 30), DCIS (n = 35), and IDC (n = 30) of the breast were analyzed for these loci.21120523
Hepatitis CEpigenetic AlterationsAutoantibodies to a miRNA-binding protein Argonaute2 (Su antigen) in patients with hepatitis C virus infection.21122261
Colorectal Cancer PathwayEpigenetic AlterationsModulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study.21123457
palladiumEpigenetic AlterationsOur findings suggest that a novel epigenetic regulatory mechanism controlling SNCA expression influences PD pathogenesis.21124796
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, NeoplasmsEpigenetic AlterationsPrevious research on the epigenetics of myelodysplastic syndromes (MDS) mainly focused on the inactivation of tumor suppressor genes as a result of DNA methylation.21125401
SF3B1 wt AlleleEpigenetic AlterationsRecent studies have revealed that DNA methylation and histone modification may be controlled by Polycomb-group (PcG) proteins, which may give new clues toward understanding the epigenetic mechanism of MDS.21125401
SF3B1 wt AlleleEpigenetic AlterationsThe MDS patients with DNA methylation had higher EZH2 expression than those without DNA methylation.21125401
SF3B1 wt AlleleEpigenetic AlterationsHowever, the basic molecular pathogenesis of epigenetics in MDS remains poorly understood.21125401
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsOverexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring.21125401
SF3B1 wt AlleleEpigenetic AlterationsThe products of these genes might participate in epigenetic regulation of MDS.21125401
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAberrant microRNA expression in Chinese patients with chronic lymphocytic leukemia.21130495
Malignant Neoplasms, Childhood LeukemiaEpigenetic AlterationsMany reports have indicated that miRNAs play a critical role in malignancies, and regulations in the progression of leukemia.21130495
Chronic Lymphocytic LeukemiaEpigenetic AlterationsHowever, the miRNAs expression level in Chinese patients with chronic lymphocytic leukemia (CLL), and its prognostic value remain elusive.21130495
Chronic Lymphocytic LeukemiaEpigenetic AlterationsIn addition, an inverse correlation was observed in the CLL samples we examined between miRNAs (miR-16-1, miR-181a, miR-181b) and BCL-2 level; furthermore, an inverse correlation was also observed between miRNAs (miR-16-1, miR-181a, miR-181b) and TCL-1, which suggest that these miRNAs may implicate in negatively regulating target mRNA at transcriptional level.21130495
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThese different miRNAs may play an important role in the pathogenesis of CLL and might be applied for the assessment of prognosis in patients with CLL.21130495
Transitional cell carcinoma of bladderEpigenetic AlterationsDifferential miRNA expression profiles in bladder urothelial carcinomas.21133599
NeoplasmsEpigenetic AlterationsCreation of lists of miRNAs differentially expressed between this tumor type and normal tissue might help identify new diagnostic and prognostic markers.21133599
Transitional cell carcinoma of bladderEpigenetic AlterationsThese findings suggest that these miRNAs may be involved in bladder urothelial carcinoma pathogenesis and have potential as biomarkers.21133599
Stomach CarcinomaEpigenetic AlterationsResults of our study imply that there is either germline mutation or an epigenetic inactivation of another MMR gene, which causes MSI phenotype in the referred gastric cancer cases.21136174
Chronic Lymphocytic LeukemiaEpigenetic AlterationsDeregulation of Aiolos expression in chronic lymphocytic leukemia is associated with epigenetic modifications.21139082
Gain, Chronic Lymphocytic LeukemiaEpigenetic AlterationsThese epigenetic modifications should allow its upstream effectors, such as nuclear factor-kB, constitutively activated in CLL, to gain access to promoter, resulting up-regulation of Aiolos.21139082
Chronic Lymphocytic LeukemiaEpigenetic AlterationsOur results strongly suggest that Aiolos deregulation by epigenetic modifications may be a hallmark of CLL.21139082
CarcinogenesisEpigenetic AlterationsMGMT promoter hypermethylation and epigenetic silencing often occur as early events in carcinogenesis.21140203
Lynch SyndromeEpigenetic AlterationsWe previously showed that constitutional 3 end deletions of EPCAM can cause Lynch syndrome through epigenetic silencing of MSH2 in EPCAM-expressing tissues, resulting in tissue-specific MSH2 deficiency.21145788
Hepatocarcinogenesis, Hollings Cancer CenterEpigenetic AlterationsA general stepwise increase in methylating events is seen during HBV-related multistep hepatocarcinogenesis, and epigenetic changes may occur predominantly in the earlier stages of HCC development.21145824
Hepatocarcinogenesis, PremalignantEpigenetic AlterationsHowever, miRNA deregulation in the pre-malignant lesions and expression changes during multistep hepatocarcinogenesis remain elusive.21145831
HepatocarcinogenesisEpigenetic AlterationsOur results showed that miRNA deregulation was an early event and accumulated throughout the various steps of HBV-associated hepatocarcinogenesis.21145831
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsOur findings also suggest that miR-145 is a candidate tumor suppressive miRNA and may play an important role in HCC development.21145831
Liver carcinomaEpigenetic AlterationsAberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake.21146512
Hollings Cancer CenterEpigenetic AlterationsHerein, we sought to establish DNA methylation patterns in HCC and corresponding cirrhotic tissues and to identify DNA methylation changes associated with major risk factors.21146512
Hollings Cancer CenterEpigenetic AlterationsWe have established assays for quantitative analysis of DNA methylation levels in a panel of seven cancer-associated genes and repetitive elements, and combined these assays with a series of HCC tumors, associated with major risk factors, collected from two different geographical areas.21146512
Hollings Cancer CenterEpigenetic AlterationsThis study identifies aberrant DNA methylation of specific cellular genes in HCC and the major risk factors associated with these changes, providing information that could be exploited for biomarker discovery in clinics and molecular epidemiology.21146512
Treatment/Psychosocial EffectsEpigenetic AlterationsEpigenetic patterns associated with the immune dysregulation that accompanies psychosocial distress.21146603
Malignant neoplasm of larynx, Malignant Head and Neck NeoplasmEpigenetic AlterationsWhile recent observations indicate the occurrence of an epigenetic field defect in head and neck cancer patients, a detailed exploration of the characteristic changes in the DNA methylation profile in laryngeal cancer patients was lacking.21147548
Laryngeal neoplasmEpigenetic AlterationsOur findings indicate the high prevalence of epigenetic abnormalities in laryngeal tumors.21147548
InitiationEpigenetic AlterationsRecent evidence indicates that small noncoding RNA molecules, known as microRNAs (miRNAs), are involved in cancer initiation and progression.21149617
Kidney Diseases, Diabetes Mellitus, Kidney Failure, ChronicEpigenetic AlterationsDNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy.21150313
Chronic kidney disease stage 5, Kidney Failure, Chronic, Kidney Diseases, Diabetes Mellitus, Chronic Kidney DiseasesEpigenetic AlterationsWe identified potential epigenetic biomarkers for chronic kidney disease progression by comparing site-specific DNA methylation levels in more than 14,000 genes between African American and Hispanic diabetes patients with end stage renal disease (ESRD) and diabetes patients without nephropathy.21150313
Kidney DiseasesEpigenetic AlterationsThe fact that these nephropathy and/or dialysis-associated differences between patients were identified in DNA extracted from saliva offers proof-of-principle that inter-individual epigenetic differences may prove useful as predictive biomarkers of disease susceptibility.21150313
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsDistinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome.21150891
SF3B1 wt Allele, Refractory anemia with excess blasts I, Refractory anemia with excess blasts IIEpigenetic AlterationsDifferences in miRNA expression of MDS subtypes showed a distinction between early and advanced MDS; an apparent dissimilarity was observed between RAEB-1 and RAEB-2 subtypes.21150891
SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsHowever, limited information is available regarding the role of miRNAs in myelodysplastic syndrome (MDS).21150891
Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic silencing of peroxisome proliferator-activated receptor g is a biomarker for colorectal cancer progression and adverse patients outcome.21151932
Clinical Coordinator, NeoplasmsEpigenetic AlterationsOur findings provide a novel mechanistic insight into epigenetic silencing of PPARG in CRC that may be relevant as a prognostic marker of tumor progression.21151932
Malignant NeoplasmsEpigenetic AlterationsAberrant promoter hypermethylation (methylation) is an epigenetic change that silences the expression of crucial genes, thus inactivating the apoptotic pathway in various cancers.21152877
Adenoma, Sessile Serrated Adenoma/PolypEpigenetic AlterationsSessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract.21154739
Glioblastoma MultiformeEpigenetic AlterationsDNA methylation in glioblastoma: impact on gene expression and clinical outcome.21156036
Glioblastoma MultiformeEpigenetic AlterationsChanges in promoter DNA methylation pattern of genes involved in key biological pathways have been reported in glioblastoma.21156036
Glioblastoma MultiformeEpigenetic AlterationsGenome-wide assessments of DNA methylation levels are now required to decipher the epigenetic events involved in the aggressive phenotype of glioblastoma, and to guide new treatment strategies.21156036
Precursor T-Cell Lymphoblastic Leukemia-LymphomaEpigenetic AlterationsEpigenetic regulation of PAX5 expression in acute T-cell lymphoblastic leukemia.21156323
CarcinogenesisEpigenetic AlterationsEpigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis.21156726
ovarian neoplasmEpigenetic AlterationsEpigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.21156726
Soft Tissue InjuriesEpigenetic AlterationsRecently, plasma miRNAs have been reported to be sensitive and specific biomarkers of various tissue injuries and pathological conditions.21157109
Malignant Neoplasms, DICER1 protein, humanEpigenetic AlterationsDicer and Drosha are key enzymes in the miRNA-processing pathway which is altered in many human cancers.21160068
Primary malignant neoplasmEpigenetic AlterationsPolycomb Group (PcG) proteins are epigenetic silencers involved in maintaining cellular identity, and their deregulation can result in cancer.21162745
Klatskin TumorEpigenetic AlterationsTaqman microRNA assay shows that down-regulation of miR-373 is closely associated with poor cell differentiation, advanced clinical stage and shorter overall and disease-free survival in hilar cholangiocarcinomas.21165562
Malignant NeoplasmsEpigenetic AlterationsAberrant expression of miRNAs is associated with particular cancers showing tissue- and clinical-feature-specificity patterns.21165562
Ulcerative ColitisEpigenetic AlterationsMiR-96 and miR-183 were differentially upregulated microRNA in our previous microRNA screening for UC.21166959
Squamous cell carcinoma, SERPINB3 wt Allele, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are epigenetic regulators of gene expression, and their deregulation plays an important role in human cancer, including oral squamous cell carcinoma (OSCC).21167132
Mammary NeoplasmsEpigenetic AlterationsAlcohol consumption in relation to aberrant DNA methylation in breast tumors.21168302
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsAlcohol may impact breast malignancies or tumor progression by altering DNA methylation.21168302
Breast CarcinomaEpigenetic AlterationsWe found alcohol consumption was associated with DNA methylation in postmenopausal breast tumors, suggesting that the association of alcohol and breast cancer may be related, at least in part, to altered methylation, and may differ by drinking pattern.21168302
Squamous cell carcinoma of esophagusEpigenetic AlterationsTo gain insight into the role of epigenetic aberration of cell-cycle regulator genes in oesophagus squamous cell carcinoma (ESCC), the authors determined the hypermethylation profile in ESCC.21169275
Fragile X SyndromeEpigenetic AlterationsIn patient-derived lymphoblasts and fibroblasts, we determined by chromatin immunoprecipitation that there is increased acetylation of histones at the FMR1 locus in pre-mutation carriers compared to control or FXS derived cell lines.21170301
NeoplasmsEpigenetic AlterationsWe performed loss-of-function and gain-of-function experiments regarding cell proliferation, cell cycle, apoptosis, in vivo tumor formation and luciferase reporter assays, using siRNAs against PLK1 and miRNA.21170987
Bladder NeoplasmEpigenetic AlterationsA novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression.21173382
Primary malignant neoplasmEpigenetic AlterationsEpigenetic silencing can extend to whole chromosomal regions in cancer.21173382
Bladder Neoplasm, Primary malignant neoplasmEpigenetic AlterationsWe searched for chromosomal regions affected by epigenetic silencing in cancer by using Affymetrix microarrays and real-time quantitative polymerase chain reaction to analyze RNA from 57 bladder tumors compared with normal urothelium.21173382
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsClustering was used to distinguish tumors with multiple regional epigenetic silencing (MRES) from those without and to analyze the association of this phenotype with histopathologic and molecular types of bladder cancer.21173382
Bladder NeoplasmEpigenetic AlterationsCell lines derived from aggressive bladder tumors presented epigenetic silencing of the same regions.21173382
Malignant neoplasm of urinary bladder, CarcinomaEpigenetic AlterationsWe have identified an MRES phenotype characterized by the concomitant epigenetic silencing of several chromosomal regions, which, in bladder cancer, is specifically associated with the carcinoma in situ gene expression signature.21173382
Secondary malignant neoplasm of liver, Colorectal CarcinomaEpigenetic AlterationsMicroRNA expression profiles in human colorectal cancers with liver metastases.21174058
Malignant Neoplasms, DiseaseEpigenetic AlterationsMicroRNAs (miRNAs) are shown to be involved in various human diseases including cancers through negative regulation of target gene expression at the post-transcriptional level.21174058
Secondary malignant neoplasm of liver, Colorectal CarcinomaEpigenetic AlterationsOf these, 4 miRNAs including miR-150*, miR-125b-2*, miR-1179 and miR-139-3p were up-regulated in colorectal cancers with liver metastasis while the others were down-regulated.21174058
Secondary malignant neoplasm of liver, Carcinogenesis, Colorectal CarcinomaEpigenetic AlterationsOur results indicated that miRNAs are not only involved in carcinogenesis of colorectum, but may also participate in the progression such as with liver metastases in human colorectal cancers.21174058
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer (CRC) is caused by an accumulation of genetic alterations and epigenetic alterations.21174064
Clinical CoordinatorEpigenetic AlterationsThe combination of genetic and epigenetic alterations may be a good marker for the prognosis of CRC patients.21174064
Carcinoma, Transitional CellEpigenetic AlterationsCopy number alterations in urothelial carcinomas: their clinicopathological significance and correlation with DNA methylation alterations.21177765
CarcinogenesisEpigenetic AlterationsBoth genetic and epigenetic events appear to accumulate during urothelial carcinogenesis, reflecting the clinicopathological diversity of UCs.21177765
DiseaseEpigenetic AlterationsChanges in DNA methylation may represent an intermediate step between the environment and human diseases.21178401
Senile angiomaEpigenetic AlterationsInvestigation of senile hemangioma and the regulatory mechanisms of angiogenesis by miRNA in the aged skin may lead to new treatments using miRNA by the transfection into senile hemangioma.21179471
Primary malignant neoplasmEpigenetic AlterationsGlobal genomic hypomethylation is a common epigenetic event in cancer that mostly results from hypomethylation of repetitive DNA elements.21188491
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAberrant expression of microRNA (miRNA) is commonly associated with cancer and loss of miR-124a has previously been implicated to function as a tumour suppressor.21196113
Ductal Breast CarcinomaEpigenetic AlterationsDiagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification.21197409
Hepatitis CEpigenetic AlterationsLiver-specific microRNA-122 (miR-122) has been shown to facilitate the replication of hepatitis C virus (HCV) in human hepatoma cells in vitro.21199296
NeoplasmsEpigenetic AlterationsIdentification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene.21199797
NeoplasmsEpigenetic AlterationsOur results indicate that tumor identity is achieved mainly by variation in the expression levels of a common set of miRNAs rather than by tissue-specific expression.21199797
Breast CarcinomaEpigenetic AlterationsTen percent of the new miRNAs are located in regions with high-level genomic amplifications in breast cancer.21199797
Breast CarcinomaEpigenetic AlterationsIn summary, our work substantially expands the number of known miRNAs and highlights the complexity of small RNA expression in breast cancer.21199797
Primary central nervous system lymphomaEpigenetic AlterationsWith a candidate approach and miRNA quantification by reverse transcription polymerase chain reaction, miRNAs with significant levels in the CSF of patients with PCNSL were identified.21200023
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are regulatory RNA molecules that are deregulated in many disease types, including cancer.21200023
Primary malignant neoplasmEpigenetic AlterationsRecently, miRNAs have shown promise as markers for cancer diagnosis.21200023
Primary central nervous system lymphomaEpigenetic AlterationsIn conclusion, CSF miRNAs are potentially useful tools as novel noninvasive biomarker for the diagnosis of PCNSL.21200023
Stomach CarcinomaEpigenetic AlterationsEpigenetics, particularly DNA methylation, has recently been elucidated as important in gastric cancer (GC) initiation and progression.21203466
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAssociation of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia.21205967
Chronic Lymphocytic LeukemiaEpigenetic AlterationsA microRNA/TP53 feedback circuitry is associated with CLL pathogenesis and outcome.21205967
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThis mechanism provides a novel pathogenetic model for the association of 13q deletions with the indolent form of CLL that involves microRNAs, TP53, and ZAP70.21205967
Fragile X SyndromeEpigenetic AlterationsEpigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.21209411
Colorectal Cancer PathwayEpigenetic AlterationsPolymorphic variants in genes involved in one-carbon metabolism, in particular of dietary folate, may modulate the risk for colorectal cancer through aberrant DNA-methylation and altered nucleotide synthesis and repair.21211571
SF3B1 wt AlleleEpigenetic AlterationsThese findings suggest that suppression of DAPK1 expression by DNA methylation may play a substantial role in the development of MDS.21212658
Squamous cell carcinoma of esophagusEpigenetic AlterationsMiRNA profile in esophageal squamous cell carcinoma: downregulation of miR-143 and miR-145.21218087
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe expression profile of miRNA in ESCC tissues was analyzed by miRNA microarray.21218087
Esophageal carcinomaEpigenetic AlterationsThe mobility effect was estimated by wound-healing using esophageal carcinoma cells transfected with miRNA expression plasmids.21218087
Squamous cell carcinoma of esophagusEpigenetic AlterationsThese findings suggest that the deregulation of miRNAs plays an important role in the progression of ESCC.21218087
NeoplasmsEpigenetic AlterationsIn recent years, microRNAs (miRNAs) have been found to play an essential role in tumor development.21219656
NeoplasmsEpigenetic AlterationsMiR-155 is one of the miRNAs most consistently involved in various neoplastic diseases.21219656
Stomach CarcinomaEpigenetic AlterationsMicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab.21220473
NeoplasmsEpigenetic AlterationsMicroRNA 125a-5p (miR-125a-5p) has been reported to be a tumor suppressor in malignancies of the breast, ovary, lung, and central nervous system.21220473
melanoma, Primary malignant neoplasmEpigenetic AlterationsWe previously reported that the miR-34a gene is subject to epigenetic inactivation by CpG methylation of its promoter region in primary prostate cancer and melanomas, and in 110 different cancer cell lines of diverse origin.21225432
Breast CarcinomaEpigenetic AlterationsFurther studies on sources of "remaining" heterogeneity of population with breast cancer (such as genetic/epigenetic characteristics) are necessary.21225455
Carcinogenesis, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsChanges in DNA methylation of tumor suppressors can occur early in carcinogenesis and are potentially important early indicators of cancer.21227392
Conventional (Clear Cell) Renal Cell Carcinoma, MetastasisEpigenetic AlterationsSpecific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma.21229250
MetastasisEpigenetic AlterationsWe aimed at identifying specific miRNA expression patterns that are associated with metastasis and prognosis in ccRCC patients.21229250
Metastasis, Neoplasms, Neoplasm MetastasisEpigenetic AlterationsMiRNA of 30 human ccRCC including ten non-metastatic tumours, four tumours with metastasis after 3 years or later and four tumours with primary metastasis was isolated.21229250
Aggressive behavior, NeoplasmsEpigenetic AlterationsFurthermore, we identified a group of 12 miRNAs, such as let-7 family, miR-30c, miR-26a, which are decreased in highly aggressive primary metastatic tumours.21229250
MetastasisEpigenetic AlterationsOur findings suggest that specific miRNAs are involved in metastasis and have an impact on the progression of the ccRCC.21229250
Aggressive behavior, MetastasisEpigenetic AlterationsFurthermore, we identified specific miRNAs characterising very aggressive tumours with early metastasis.21229250
Primary Neoplasm, MetastasisEpigenetic AlterationsThus, it seems possible to use miRNAs for prediction of progression to distant metastasis and prognosis analysing the primary tumour.21229250
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe hallmark of cancer epigenetics is aberrant DNA methylation consisting of global hypomethylation and regional hypermethylation of tumor suppressor genes (TSGs) by DNA methyltransferases (DNMTs).21229291
Primary malignant neoplasmEpigenetic AlterationsThe role of epigenetics and significance of aberrant gene regulation in etiology of cancer is a well-established phenomenon.21229291
GliomaEpigenetic AlterationsEpigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas.21229291
GliomaEpigenetic AlterationsInterestingly, little is known about variation in the methylation status of epigenetic regulators themselves in gliomas.21229291
Malignant neoplasm of lung, NeoplasmsEpigenetic AlterationsAberrant DNA methylation of some tumor suppressor genes in lung cancers from workers with chromate exposure.21229606
Primary malignant neoplasmEpigenetic AlterationsNumerous studies have shown that aberrant microRNA (miRNA) expression is associated with the development and progression of various types of human cancer and serum miRNAs are potential biomarkers.21229610
Liver carcinoma, Hepatitis, ChronicEpigenetic AlterationsCirculating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis.21229610
Hepatitis, ChronicEpigenetic AlterationsHowever, these elevated serum miRNAs were also detected in patients with chronic hepatitis (P = 2.05 x 10-12, P = 4.52 x 10-16, and P = 1.65 x 10-11, respectively).21229610
Squamous cell carcinomaEpigenetic AlterationsAs epithelial-mesenchymal transition is the postulated pathogenetic mechanism in spindle cell carcinoma, we analyzed the expression of these microRNAs in spindle cell carcinoma of the head and neck in comparison to conventional squamous cell carcinoma of similar location and stage.21237487
Carcinoma, Spindle-CellEpigenetic AlterationsThese microRNAs act on transcription repressors that were also up-regulated in our cases of spindle cell carcinoma, both on mRNA and on protein levels.21237487
cervical cancer, NeoplasmsEpigenetic AlterationsEpigenetic regulation of the potential tumor suppressor gene, hLHX6.1, in human cervical cancer.21240459
cervical cancerEpigenetic AlterationsThis epigenetic alteration in the hLHX6.1 promoter begins at a relatively early stage, suggesting its potential as a biomarker for the early diagnosis and prevention of cervical cancer.21240459
Lung Diseases, InterstitialEpigenetic AlterationsSystems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes.21241464
Gastrointestinal Stromal Tumors, MetastasisEpigenetic AlterationsAlthough the main cause of gastrointestinal stromal tumor (GIST) is gain-of-function mutations in the c-kit gene in the interstitial cells of Cajal, concomitant genetic or epigenetic changes other than c-kit appear to occur in the development of metastasis.21244575
Oral Cavity Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA expression profiling of oral carcinoma identifies new markers of tumor progression.21244772
NeoplasmsEpigenetic AlterationsThirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours.21244772
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsSince miRNAs have been shown to be abnormally expressed in different tumours their importance as potential cancer prognostic indicators is increasing.21244772
Carcinoma of lungEpigenetic AlterationsEpigenetic mechanisms for silencing glutathione S-transferase m2 expression by hypermethylated specificity protein 1 binding in lung cancer.21246532
Malignant NeoplasmsEpigenetic AlterationsWe hypothesized that p53 mutations may lead to different transcriptional changes and carry different prognostic value in these two different types of cancers.21248301
Behavior, CarcinogenesisEpigenetic AlterationsAbnormal miRNA expression has emerged as crucial factors in carcinogenesis and is important in the comprehension of prostate cancer behavior.21255804
Prostate Cancer PathwayEpigenetic AlterationsWe determined the correlation of miRNA expression profiles with prostate cancer progression.21255804
Breast Cancer CellEpigenetic AlterationsAberrant DNA methylation is a common phenomenon in human cancer.21255913
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThus, the results indicated that methylated alteration of multiple genes plays an important role in NSCLC pathogenesis and a panel of candidate epigenetic biomarkers for NSCLC detection in the Chinese population was identified.21255913
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer.21258252
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA profiling was performed on total RNA extracted from serum obtained from 22 individuals (11 controls and 11 patients with early-stage NSCLC).21258252
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese miRNAs may serve as biomarkers for NSCLC early detection.21258252
Non-Small Cell Lung CarcinomaEpigenetic AlterationsReceiver operating characteristic curves plotting these two miRNAs were able to discriminate early-stage NSCLC samples from controls with 82% and 77% of sensitivity and specificity, respectively, in the discovery cohort and with 73% and 71% of sensitivity and specificity, respectively, in the validation cohort.21258252
Non-Small Cell Lung CarcinomaEpigenetic AlterationsSerum miRNAs are differentially expressed between patients with early-stage NSCLC and controls.21258252
CarcinogenesisEpigenetic AlterationsHere, we first evaluated SMARCA5 expression and promoter DNA methylation in gastric carcinogenesis.21261476
melanomaEpigenetic AlterationsImmunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi.21262599
Malignant Neoplasms, melanomaEpigenetic AlterationsAlthough a variety of malignancies have been attributed to perturbations in the miRNA machinery, there has been little research conducted on the role of miRNAs in cutaneous malignant melanoma and its premalignant lesions.21262599
DICER1 protein, humanEpigenetic AlterationsDicer is an essential cytosolic enzyme necessary for processing pre-microRNAs into mature microRNAs (miRNAs).21262599
NeoplasmsEpigenetic Alterationsp14(ARF), p15(INK4b), and p16(INK4a) are tumor suppressor genes that are located closely at 9p21 and are often coinactivated by genetic or epigenetic alterations.21262917
Malignant tumor of colon, Colonic NeoplasmsEpigenetic AlterationsWe determined that DNA methylation of the YPEL3 promoter CpG island does not play a role in YPEL3 regulation in human colon tumors or colon cancer cells lines, consistent with the inability of 5-azadeoxycytidine treatment to induce YPEL3 expression in colon cancer cell lines.21267786
Malignant tumor of colonEpigenetic AlterationsIn contrast, colon cell line results suggest that histone acetylation may play a role in YPEL3 regulation in colon cancer.21267786
Adenocarcinoma of colonEpigenetic AlterationsHistone acetylation may be a relevant epigenetic modulator of YPEL3 in colon adenocarcinomas.21267786
Malignant NeoplasmsEpigenetic AlterationsAlthough the precise molecular mechanisms by which LOI of IGF2 increases GC risk require further study, LOI of IGF2 may be a potentially important clinical epigenetic marker to identify individuals at increased risk for gastric malignancy.21268128
Primary malignant neoplasm, Neoplasm MetastasisEpigenetic AlterationsThe accumulation of a single microRNA in the bone marrow has the potential to regulate the translation of multiple genes in cancer metastasis and may therefore serve as a prognostic marker for cancer recurrence.21271219
Breast CarcinomaEpigenetic AlterationsThe much higher significant correlation with microRNA levels and prognosis suggests epistatic effects on multiple target genes in the bone marrow of breast cancer patients.21271219
Breast CarcinomaEpigenetic AlterationsIdentification of recurrence-related microRNAs in the bone marrow of breast cancer patients.21271219
Breast CarcinomaEpigenetic AlterationsAccumulation of two of these microRNAs, miR-21 and miR-181a, in the recurrent breast cancer cases was validated by RT-PCR in bone marrow from 291 additional breast cancer cases.21271219
Colorectal Cancer Pathway, PremalignantEpigenetic AlterationsTo evaluate association between DNA methylation of MAL, CDKN2A, and MGMT in stool and development of colorectal cancer, and to evaluate the screening value of these biomarkers in colorectal cancer and pre-malignant lesions.21271382
Colorectal Cancer Pathway, Premalignant, Colonic adenomasEpigenetic AlterationsDNA methylations levels of MAL, CDKN2A, and MGMT in stools are significantly higher in colorectal cancer and colon adenoma, which may serve as an noninvasive approach for the screening of colorectal cancer and pre-malignant lesions.21271382
melanoma, NeoplasmsEpigenetic AlterationsThe circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker.21273047
melanomaEpigenetic AlterationsMicroRNA-221 (miR-221) is known to be abnormally expressed in malignant melanoma (MM) cells, and it favors the induction of the malignant phenotype through down-modulation of p27Kip1/CDKN1B and the c-KIT receptor.21273047
Malignant neoplasm of urinary bladderEpigenetic AlterationsTo prove the epigenetic regulation of OPCML, five bladder cancer cell lines were exposed to 5-aza-2deoxycytidine (5-aza-dC), a specific DNA methyltransferase inhibitor and trichostatin A (TSA), a histone deacetylase inhibitor.21273058
Carcinoma, Transitional Cell, Transitional cell carcinoma of bladder, CarcinogenesisEpigenetic AlterationsThe high frequency of OPCML promoter methylation in urothelial carcinomas suggests an important role for this epigenetic alteration in bladder carcinogenesis, highlighting its potential as an epigenetic biomarker for bladder urothelial carcinoma with prognostic significance.21273058
Gastric Cardia AdenocarcinomaEpigenetic AlterationsEpigenetic silencing of Wnt-antagonist genes expression by promoter hypermethylation may play an important role in gastric cardia adenocarcinoma.21275459
Papillary thyroid carcinomaEpigenetic AlterationsDevelopment of a microRNA-based molecular assay for the detection of papillary thyroid carcinoma in aspiration biopsy samples.21275764
Thyroid NeoplasmEpigenetic AlterationsmiRNA quantification for differential diagnosis of thyroid neoplasms within aspiration biopsy samples is feasible and may improve the accuracy of FNAB cytology.21275764
Carcinoma of lungEpigenetic AlterationsRecently, epigenetic aberration of lung cancer, not only genomic DNA methylation but also chromatin modification, has become an important target for lung cancer research, although previous research has demonstrated that lung cancer develops as a result of both environmental and genetic factors.21276135
Malignant tumor of colonEpigenetic AlterationsMoreover, DNA methylation of selected ECM genes helps to stratify the high-risk stage 2 colon cancers patients who would benefit from adjuvant chemotherapy (HR: 5.85, 95% CI: 2.03-16.83, P = 0.001 for simultaneous methylation of IGFBP3, EVL, and CD109).21278247
Clinical CoordinatorEpigenetic AlterationsWe identified 29 low frequency-mutated genes that are also inactivated by epigenetic mechanisms in CRC.21278247
Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsCRC that have silenced genes in ECM pathway components show worse survival suggesting that our finding provides novel prognostic biomarkers for CRC and reflects the high importance of integrative analyses linking genetic and epigenetic abnormalities with pathway disruption in cancer.21278247
Hollings Cancer CenterEpigenetic AlterationsRecent reports suggest a link between aberrant expression of miRNA, and HCC.21278583
Liver carcinomaEpigenetic AlterationsCirculating microRNAs as biomarkers for hepatocellular carcinoma.21278583
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsIn addition to genetic and epigenetic alterations, some genetic polymorphisms in the genes associated with the Wnt signaling pathway have been reported to be associated with an increased risk of cancer, including breast cancer.21279955
Autoimmune DiseasesEpigenetic AlterationsMicroRNA reflect physiologic and pathologic processes and may be used as biomarkers of concurrent pathophysiologic events in complex settings such as autoimmune diseases.21280008
Stomach CarcinomaEpigenetic AlterationsExpression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer.21281785
Stomach CarcinomaEpigenetic AlterationsFurthermore, epigenetic alterations in CA9 differ between the intestinal and diffuse types of gastric cancer.21281785
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsDNA methylation changes following 5-azacitidine treatment in patients with myelodysplastic syndrome.21286011
Childhood LeukemiaEpigenetic AlterationsFurthermore, we found that Evi1 binds to several polycomb group proteins and recruits polycomb repressive complexes for PTEN down-regulation, which shows a novel epigenetic mechanism of AKT/mTOR activation in leukemia.21289308
Metastasis, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, NeoplasmsEpigenetic AlterationsMicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells.21294122
Neoplasm MetastasisEpigenetic AlterationsMicroRNA-200c (miR200c) is emerging as an important regulator of tumourigenicity and cancer metastasis with a strong capacity for inducing epithelial-mesenchymal transitions.21294122
Parkinson DiseaseEpigenetic AlterationsIdentification of blood microRNAs associated to Parkinsonis disease.21295623
Alzheimers DiseaseEpigenetic AlterationsDNA methylation in repetitive elements and Alzheimer disease.21296655
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsEpigenetics is believed to play a role in Alzheimers disease (AD).21296655
X-linked inheritance, AutosomeEpigenetic AlterationsWe used quantitative mRNA expression and DNA methylation analyses to determine the relationship between expression and methylation of X-linked (MAGE-A1, NY-ESO-1, XAGE-1) and autosomal (BORIS, SOHLH2) CG genes, global DNA methylation (5mdC levels, LINE-1, Alu, and Sat-a methylation), and clinicopathology, using 75 EOC samples.21296871
NeoplasmsEpigenetic AlterationsHigh-level DNA methylation was found in 16% of chromosomal instable tumors and in 44% of both microsatellite instable and microsatellite and chromosomally stable carcinomas.21297586
Cervical Intraepithelial Neoplasia, Adenocarcinoma of small intestineEpigenetic AlterationsGenetics and epigenetics of small bowel adenocarcinoma: the interactions of CIN, MSI, and CIMP.21297586
NeoplasmsEpigenetic AlterationsCharacterization of tumor genetics and epigenetics allows to stratify a tumor entity according to molecular pathways and may shed light on the interactions of different types of DNA alterations during tumorigenesis.21297586
Liver carcinomaEpigenetic AlterationsMicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan Criteria.21298008
Hollings Cancer CenterEpigenetic AlterationsMicroRNA profiling can predict HCC recurrence in Milan criteria cases.21298008
Clinical CoordinatorEpigenetic AlterationsHowever, there is limited knowledge of the DNA methylation pattern in CRC.21298349
Colorectal Cancer PathwayEpigenetic AlterationsEpigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations.21298349
Primary malignant neoplasmEpigenetic AlterationsMost human cancer types result from the accumulation of multiple genetic and epigenetic alterations in a single cell.21301064
Sjogrens SyndromeEpigenetic AlterationsAlterations in type I hemidesmosome components suggestive of epigenetic control in the salivary glands of patients with Sjogrens syndrome.21305504
Cervical Intraepithelial NeoplasiaEpigenetic AlterationsHigh-risk human papillomavirus reduces the expression of microRNA-218 in women with cervical intraepithelial neoplasia.21309487
Hematologic NeoplasmsEpigenetic AlterationsEpigenetic inactivation of the hsa-miR-203 in haematological malignancies.21323860
NeoplasmsEpigenetic AlterationsmiR-203 is a tumour suppressor microRNA (miRNA).21323860
Lymphoma, Non-Hodgkin, Acute lymphocytic leukemia, Myeloid Leukemia, Chronic, Lymphoma, Large-Cell, Follicular, Chronic Lymphocytic Leukemia, Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe studied the methylation of hsa-miR-203 in 150 samples including acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), chronic myeloid leukaemia (CML), chronic lymphocytic leukaemia (CLL) and non-Hodgkins lymphoma (NHL) by methylation-specific PCR, and miRNA expression by stem-loop RT-qPCR.21323860
Lymphoma, Large-Cell, Follicular, NeoplasmsEpigenetic AlterationsIn NHL, hsa-miR-203 methylation was associated with concomitant methylation of other tumour suppressor miRNAs.21323860
Malignant neoplasm of endometrium, Type 2Epigenetic AlterationsThis raises the hypothesis that one-carbon nutrients (folate, methionine, and the enzymic cofactors vitamins B2, B6, and B12), which mediate chromosomal stability and DNA methylation, may be protective for type II but not type I endometrial cancer.21324952
Mitral Valve Stenosis, Atrial FibrillationEpigenetic AlterationsMicroRNA expression signature in atrial fibrillation with mitral stenosis.21325063
Microbiology Susceptibility Domain, Atrial FibrillationEpigenetic AlterationsmiRNA arrays revealed that 136 and 96 miRNAs were expressed at different levels in MS patients with AF and in MS patients without AF, respectively, compared with healthy controls.21325063
Colorectal CarcinomaEpigenetic AlterationsOnly HLTF, HPP1/TPEF, and NEUROG1 DNA methylation was detectable in at least 50% of patients with colorectal cancers.21326223
Colorectal Cancer PathwayEpigenetic AlterationsThe quantitative detection of NEUROG1 DNA methylation in serum is a suitable approach for the non-invasive screening for asymptomatic colorectal cancer.21326223
Malignant Neoplasms, HereditaryEpigenetic AlterationsOur results highlight the importance of epigenetic events in hereditary and sporadic cancers and suggest that MS-MLPA is an excellent choice for quantitative analysis of methylation in archival formalin-fixed, paraffin-embedded samples, which pose challenges to many other techniques commonly used for methylation studies.21327300
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small noncoding RNAs that contribute to tumorigenesis by acting as oncogenes or tumor suppressor genes and may be important in the diagnosis, prognosis and treatment of cancer.21327300
Carcinoma, HereditaryEpigenetic AlterationsAltered methylation at microRNA-associated CpG islands in hereditary and sporadic carcinomas: a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)-based approach.21327300
Neoplasms, Hereditary DiseasesEpigenetic AlterationsThe frequencies with which the individual miRNA loci were affected in tumors showed statistically significant differences relative to the tissue of origin (colorectal versus gastric versus endometrial), MMR proficiency versus deficiency and sporadic versus hereditary disease.21327300
NeoplasmsEpigenetic AlterationsHypermethylation at miRNA loci correlated with hypermethylation at classic tumor suppressor promoters in the same tumors.21327300
Malignant Neoplasms, Hereditary Malignant Neoplasm, HereditaryEpigenetic AlterationsCompared with sporadic cancers, the role of miRNAs in hereditary or familial cancer is poorly understood.21327300
NeoplasmsEpigenetic AlterationsCompared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152 and 18b; decreased methylation for 200a and 208a; and no major change for 373 and let-7a-3.21327300
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsIdentification of a risk dependent microRNA expression signature in myelodysplastic syndromes.21332710
SF3B1 wt AlleleEpigenetic AlterationsWe identified a thirteen microRNA signature with statistically significant differential expression between normal and MDS specimens (P < 0*01), including down-regulation of members of the leukaemia-associated MIRLET7 family.21332710
NeoplasmsEpigenetic AlterationsMicroRNAs play an important role in tumour suppression and the regulation of self-renewal and differentiation of haematopoietic progenitors.21332710
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, AcuteEpigenetic AlterationsPolo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions.21340720
Cytogenetically normal acute myeloid leukemia, Leukemia, Myelocytic, AcuteEpigenetic AlterationsTo determine the frequency of TET2 mutations, their associations with clinical and molecular characteristics and outcome, and the associated gene- and microRNA-expression signatures in patients with primary cytogenetically normal acute myeloid leukemia (CN-AML).21343549
SMIM6 geneEpigenetic AlterationsWe identified a TET2 mutation-associated gene-expression signature in favorable-risk but not in intermediate-I-risk patients and found distinct mutation-associated microRNA signatures in both ELN groups.21343549
Malignant neoplasm of urinary bladderEpigenetic AlterationsDNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer.21343564
malignant diseaseEpigenetic AlterationsChanges in DNA methylation in nontarget tissues, specifically peripheral blood, can also affect risk of malignant disease.21343564
Malignant neoplasm of urinary bladderEpigenetic AlterationsWe sought to identify specific profiles of DNA methylation in peripheral blood that are associated with bladder cancer risk and therefore serve as an epigenetic marker of disease susceptibility.21343564
Malignant neoplasm of urinary bladderEpigenetic AlterationsIn a training set of 112 cases and 118 controls, we identified a panel of 9 CpG loci whose profile of DNA methylation was significantly associated with bladder cancer in a masked, independent testing series of 111 cases and 119 controls (P < .0001).21343564
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations in tissues targeted for cancer play a causal role in carcinogenesis.21343564
Malignant neoplasm of urinary bladder, Malignant NeoplasmsEpigenetic AlterationsThese results indicate that profiles of epigenetic states in blood are associated with risk of bladder cancer and signal the potential utility of epigenetic profiles in peripheral blood as novel markers of susceptibility to this and other malignancies.21343564
NeoplasmsEpigenetic AlterationsWeaker associations in CRLM suggest involvement of other unknown factors possibly from the liver microenvironment or resulting from additional genetic or epigenetic changes that drive tumour metastatic capability in OPN transcriptional control.21343932
Prostate Cancer PathwayEpigenetic AlterationsImprovement of prostate cancer detection by integrating the PSA test with miRNA expression profiling.21345070
DICER1 protein, humanEpigenetic AlterationsThe RNASE III endonuclease Dicer is one of the key enzymes of microRNA biogenesis.21345667
Colorectal Cancer PathwayEpigenetic AlterationsStrong expression of the central microRNA biosynthesis enzyme Dicer predicts poor prognosis in patients with colorectal cancer.21345667
NeoplasmsEpigenetic AlterationsWe profiled miRNA expression in stage I EOC tumours to assess whether there is a miRNA signature associated with overall and progression-free survival (PFS) in stage I EOC.21345725
NeoplasmsEpigenetic Alterations89 samples from tumour tissue collection A were stratified into a training set (51 samples, 15 of which were from patients who relapsed) for miRNA signature generation, and into a validation set (38 samples, seven of which were from patients who relapsed) for signature validation.21345725
Hantavirus InfectionsEpigenetic AlterationsGenetic or epigenetic alterations in DNMT genes do not appear to be associated with HPS, but further investigation of genetic variation at rs62106244 is justified given the high frequency of the minor allele in this case series.21347319
Primary malignant neoplasmEpigenetic AlterationsNormal proliferating cells and cancer cells express the sense mitochondrial ncRNA (SncmtRNA).21347712
Stomach CarcinomaEpigenetic AlterationsMicroRNA-146a is down-regulated in gastric cancer and regulates cell proliferation and apoptosis.21347720
Malignant Neoplasms, Stomach CarcinomaEpigenetic AlterationsAberrant expression of microRNA-146a (miR-146a) has been reported to be involved in development and progression in various types of cancers, but its role in gastric cancer has not been fully elucidated.21347720
Pancreatic carcinomaEpigenetic AlterationsMicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer.21347785
Pancreatic carcinomaEpigenetic AlterationsOur aim was to identify promising microRNAs as markers to predict responses to gemcitabine in patients with resected pancreatic cancer.21347785
Pancreatic carcinomaEpigenetic AlterationsEleven miRNAs were selected as putative predictive markers and analyzed by means of macrodissected formalin-fixed, paraffin-embedded samples obtained from 90 patients with or without gemcitabine treatment after resection of pancreatic cancer.21347785
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThere is increasing evidence that altered microRNA expression is associated with tumor progression and survival in cancer patients.21350005
Adenocarcinoma of lung, stage IEpigenetic AlterationsWe tested if the expression of specific microRNAs was associated with prognosis and disease progression in early-stage lung adenocarcinoma.21350005
Prostate Cancer Pathway, Carcinogenesis, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThere have been several reports of miRNA deregulation in prostate cancer (PCa) and the biological evidence for an involvement of miRNAs in prostate tumorigenesis is increasing.21351256
Adenocarcinoma of lung (disorder)Epigenetic AlterationsEarly detection of lung adenocarcinoma in sputum by a panel of microRNA markers.21351266
NeoplasmsEpigenetic AlterationsFrom the surgical tissues, 7 miRNAs with significantly altered expression were identified, of which "4" were overexpressed and "3" were underexpressed in all 20 tumors.21351266
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsEpigenetic alteration, using promoter hypermethylation of hMLH1 gene, is important for the development of head and neck squamous cell carcinoma (HNSCC).21353335
SF3B1 wt AlleleEpigenetic AlterationsTherefore, zo-1 gene hypermethylation may be served as a useful epigenetic marker in the differential diagnosis for MDS.21362226
Stomach CarcinomaEpigenetic AlterationsMethylation-specific PCR (MS-PCR) was used to detect the DNA methylation status of hsa-miR-124a in gastric cancer tissues and adjacent normal tissues from 30 patients.21365509
Multiple SclerosisEpigenetic AlterationsChanged histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions.21368055
Multiple SclerosisEpigenetic AlterationsHere, we report, in humans brains, a shift toward histone acetylation in the white matter of the frontal lobes of aged subjects and in patients with chronic multiple sclerosis (MS).21368055
Endometrial NeoplasmsEpigenetic AlterationsMicrosatellite instability and DNA methylation of endometrial tumors and clinical features in young women compared with older women.21370598
Malignant NeoplasmsEpigenetic AlterationsWe have assayed cancers for microsatellite instability (MSI) and DNA methylation from a large group of patients younger than 50 years and a comparable group of older women.21370598
Malignant NeoplasmsEpigenetic AlterationsOn the basis of previous reports on methylation in other cancers, we hypothesized that the absence of RSK4 transcript is associated with epigenetic silencing rather than mutation.21372219
Nasopharyngeal carcinomaEpigenetic AlterationsmicroRNA expression profiling of nasopharyngeal carcinoma.21373758
Breast CarcinomaEpigenetic AlterationsmicroRNA (miRNA) are short, noncoding RNA that negatively regulate gene expression and may play a causal role in invasive breast cancer.21375733
Invasive carcinoma of breastEpigenetic AlterationsExpression of microRNA and their gene targets are dysregulated in preinvasive breast cancer.21375733
NeoplasmsEpigenetic AlterationsSince many genetic aberrations of invasive disease are detectable in early stages, we hypothesized that miRNA expression dysregulation and the predicted changes in gene expression might also be found in early breast neoplasias.21375733
Ductal Carcinoma, Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsExpression profiling of 365 miRNA by real-time quantitative polymerase chain reaction assay was combined with laser capture microdissection to obtain an epithelium-specific miRNA expression signature of normal breast epithelium from reduction mammoplasty (RM) (n = 9) and of paired samples of histologically normal epithelium (HN) and ductal carcinoma in situ (DCIS) (n = 16).21375733
Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsThirty-five miRNA were aberrantly expressed between RM, HN and DCIS.21375733
Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsTwenty-nine miRNA and 420 mRNA were aberrantly expressed between HN and DCIS.21375733
Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsKnockdown of the putative oncogenic miRNA miR-182 and miR-183, both highly overexpressed in DCIS, increased the expression of chromobox homolog 7 (CBX7) (which regulates E-cadherin expression), DOK4, NMT2 and EGR1.21375733
Invasive carcinoma of breastEpigenetic AlterationsThese data provide the first miRNA expression profile of normal breast epithelium and of preinvasive breast carcinoma.21375733
Malignant NeoplasmsEpigenetic AlterationsFurther, we demonstrate that altered miRNA expression can modulate gene expression changes that characterize these early cancers.21375733
Breast CarcinomaEpigenetic AlterationsWe conclude that miRNA dysregulation likely plays a substantial role in early breast cancer development.21375733
Squamous cell carcinoma of esophagusEpigenetic AlterationsDiet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma.21375764
Squamous cell carcinoma of esophagusEpigenetic AlterationsNo significant relation was observed between aberrant DNA methylation of P16, MGMT and hMLH1 gene, as well as MTHFR C677T genetic polymorphisms and the prognosis of ESCC.21375764
Neoplasms, Prostate carcinomaEpigenetic AlterationsHerein we report that in a large and diverse cohort of prostate carcinoma samples, miR-221 is down-regulated in patients with tumours bearing TMPRSS2:ERG fusion transcripts, thus providing a link between miRNA and gene fusion expression.21378318
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, NeoplasmsEpigenetic AlterationsmiR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma.21378409
Hypopharyngeal Squamous Cell Carcinoma, Primary malignant neoplasmEpigenetic AlterationsBased on the microRNA (miRNA) expression signatures of hypopharyngeal and esophageal squamous cell carcinoma, we found that miR-1 was significantly down-regulated in cancer cells.21378409
NeoplasmsEpigenetic AlterationsOur data indicate that TAGLN2 may have an oncogenic function and may be regulated by miR-1, a tumor suppressive miRNA in HNSCC.21378409
SERPINB3 wt Allele, NeoplasmsEpigenetic AlterationsHypermethylation of CpG islands is a common epigenetic mechanism that leads to gene silencing in tumors and could be a useful biomarker in OSCC.21380558
NeoplasmsEpigenetic AlterationsSuppression of miR-218 was associated with epigenetic silencing of SLIT2 and SLIT3, ligands of ROBO receptors that have been previously implicated in tumor angiogenesis.21385904
Acute lymphocytic leukemiaEpigenetic AlterationsAberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL).21386967
Acute lymphocytic leukemiaEpigenetic AlterationsFrequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia.21386967
Acute lymphocytic leukemiaEpigenetic AlterationsAll these findings indicate that TP53 pathway is altered by epigenetic mechanisms in the majority of ALL patients and correlates with prognosis.21386967
Acute lymphocytic leukemiaEpigenetic AlterationsTreatments with compounds that may reverse the epigenetic abnormalities or activate directly the p53 pathway represent a new therapeutic alternative for patients with ALL.21386967
Carcinoma of lung, Chronic Obstructive Airway DiseaseEpigenetic AlterationsSpecific peripheral miRNA profiles for distinguishing lung cancer from COPD.21388703
Carcinoma of lungEpigenetic AlterationsRecently we reported differential miRNA signatures in blood cells of lung cancer patients and healthy controls.21388703
Carcinoma of lung, Chronic Obstructive Airway DiseaseEpigenetic AlterationsThe miRNA pattern from patients with lung cancer and COPD were more similar to each other than to the healthy controls.21388703
Carcinoma of lung, Chronic Obstructive Airway DiseaseEpigenetic AlterationsIn conclusion, we showed that blood miRNA signatures are suitable to distinguish lung cancer from COPD.21388703
Carcinoma of lung, Chronic Obstructive Airway DiseaseEpigenetic AlterationsWe compared the expression of 863 human miRNAs in blood cells of lung cancer patients, COPD patients, and healthy controls.21388703
Carcinoma of lung, Chronic Obstructive Airway DiseaseEpigenetic AlterationsIn total, 140 miRNAs were significant for the comparison COPD and controls, 61 miRNAs were significant for the comparison lung cancer and controls, and 14 miRNAs were significant for the comparison lung cancer and COPD.21388703
Carcinoma of lung, Non-MalignantEpigenetic AlterationsThe predicted mRNA targets of three of the 14 miRNAs were significantly up-regulated in PBMCs of lung cancer patients compared to patients with non-malignant lung diseases.21388703
Breast CarcinomaEpigenetic AlterationsMicroRNA-301 mediates proliferation and invasion in human breast cancer.21393507
Breast CarcinomaEpigenetic AlterationsSeveral microRNAs have been implicated in human breast cancer but none to date have been validated or utilized consistently in clinical management.21393507
Primary malignant neoplasmEpigenetic AlterationsThe concentrations of cell-free DNA (p = 0.0001), serum microRNAs (p = 0.0001) and caspase activities (p = 0.0001) significantly discriminated cancer patients from healthy individuals.21398193
Carcinoma of lungEpigenetic AlterationsThe findings of our pilot study suggest that the assays for circulating DNA, microRNAs and caspase activities in blood might become novel minimally invasive diagnostic tools for detection and risk assessment of lung cancer, provided that their clinical utility can be confirmed in larger prospective trials.21398193
NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumor-suppressive microRNAs (miRNAs) is a key oncogenic mechanism for the activation of oncogenes in tumors.21399664
Neoplasms, Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia.21399664
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAmong these miRNAs, miR-193a was embedded in a CpG island and epigenetically repressed by promoter hypermethylation in acute myeloid leukemia (AML) cell lines and primary AML blasts, but not in normal bone marrow cells.21399664
Breast Cancer Cell, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer.21399871
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA miR-125b is a prognostic marker in human colorectal cancer.21399871
CarcinogenesisEpigenetic AlterationsThe criteria combining DNA methylation status for the 30 regions including the 45 CpG sites were able to diagnose N as being at high risk of carcinogenesis with 100% sensitivity and specificity in the learning cohort and 95.6% sensitivity and 100% specificity in the validation (n=90) cohort.21400512
Hepatitis, Hepatitis B, Liver CirrhosisEpigenetic AlterationsThe DNA methylation status of the 30 regions did not depend on the presence or absence of hepatitis virus infection, or the status of noncancerous liver tissue (chronic hepatitis or cirrhosis).21400512
Prostate carcinomaEpigenetic AlterationsMicroRNA profiles of prostate carcinoma detected by multiplatform microRNA screening.21400514
Prostate Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsTo characterize the diagnostic potential of miRNAs in prostate cancer, a leading cause of cancer mortality, we performed screening of miRNA expression profiles.21400514
Primary malignant neoplasmEpigenetic AlterationsWe used commercially available microarrays to establish miRNA expression profiles from a cohort of 20 cancer samples.21400514
Primary malignant neoplasmEpigenetic AlterationsWe identified 25 miRNAs that showed a significant differential expression in cancer samples.21400514
Prostate Cancer PathwayEpigenetic AlterationsOur data extend the knowledge about the deregulation of miRNAs in prostate cancer.21400514
NeoplasmsEpigenetic AlterationsThe differential expression of several miRNAs is highly consistent using independent cohorts of tumor samples, different tissue preservation methods and different experimental methods.21400514
Prostate Cancer PathwayEpigenetic AlterationsOur results indicate that combinations of miRNAs are promising biomarkers for the diagnosis of prostate cancer.21400514
Secondary malignant neoplasm of liverEpigenetic AlterationsTo decipher the epigenetic alterations during the development of liver metastasis, the DNA methylation status of 12 genes, including 5 classical CpG island methylator phenotype (CIMP) markers, was analyzed in 62 liver metastases and in 78 primary CRCs (53 stage I-III; 25 stage IV).21406167
Colorectal Carcinoma, MetastasisEpigenetic AlterationsDistinct profiles of epigenetic evolution between colorectal cancers with and without metastasis.21406167
Secondary malignant neoplasm of liver, Colorectal Cancer Pathway, Clinical CoordinatorEpigenetic AlterationsLiver metastasis is a fatal step in the progression of colorectal cancer (CRC); however, the epigenetic evolution of this process is largely unknown.21406167
Mycosis FungoidesEpigenetic AlterationsmiRNA expression profiling of mycosis fungoides.21406335
Childhood Leukemia, Sezary Syndrome, SeizuresEpigenetic AlterationsPreviously we examined the miRNA profile of Sezary syndrome (Sz), a leukemia of skin-homing memory T cells.21406335
Inflammatory dermatosis, Lichen Planus, Eczema, NeoplasmsEpigenetic AlterationsThe miRNA profile of skin biopsies from 19 patients with tumor stage MF and 12 patients with benign inflammatory dermatoses (eczema and lichen planus) were compared by microarray analysis.21406335
NeoplasmsEpigenetic AlterationsDifferential expression of a selection of these miRNAs was validated by miRNA-Q-PCR on additional test groups (tumors and controls).21406335
NeoplasmsEpigenetic AlterationsTaken together this report is the first describing the miRNA signature of tumor stage MF.21406335
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many malignancies including lymphoma.21406335
Inflammatory dermatosis, NeoplasmsEpigenetic AlterationsWe identified 49 miRNAs that are differentially expressed in tumor stage MF compared to benign inflammatory dermatoses using ANOVA analysis (P < 0.05, Benjamini-Hochberg corrected).21406335
NeoplasmsEpigenetic AlterationsThe majority of the differentially expressed miRNAs (30/49) were up-regulated in tumor stage MF.21406335
NeoplasmsEpigenetic AlterationsNone of the miRNAs up-regulated in tumor stage MF was previously shown to be up-regulated in Sz, and only 2 of the 19 miRNAs down-regulated in tumor stage MF were also down-regulated in Sz.21406335
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer.21406965
Colorectal Cancer PathwayEpigenetic AlterationsClinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer.21412018
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsThe clinical significance of microRNA-21 (miR-21) and miR-155 in colorectal cancer (CRC) patients remains elusive.21412018
Clinical Coordinator, NeoplasmsEpigenetic AlterationsmiR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays, and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR (RT-PCR).21412018
LipomaEpigenetic AlterationsAlthough overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs, we did not observe a significant link with let-7 inhibition in such cases.21412931
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsAlterations in DNA methylation have been implicated in the pathogenesis of myelodysplastic syndromes (MDS), although the underlying mechanism remains largely unknown.21415852
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small noncoding RNAs that regulate the expression of protein-encoding genes and are involved in the development, progression and prognosis of other malignancies.21420070
Adenocarcinoma Of EsophagusEpigenetic AlterationsMicroRNA prognostic signature for nodal metastases and survival in esophageal adenocarcinoma.21420070
Malignant neoplasm of esophagusEpigenetic AlterationsWe hypothesized that global miRNA expression would predict survival and lymph node involvement in a cohort of surgically resected esophagus cancer patients.21420070
Malignant neoplasm of esophagusEpigenetic AlterationsThese results suggest miRNA expression profiling could provide prognostic utility in staging esophagus cancer patients and treatment planning with endoscopic and neoadjuvant therapies.21420070
MetastasisEpigenetic AlterationsThe expression of three miRNAs (miR-99b and miR-199a_3p and _5p) was also associated with the presence of lymph node metastasis.21420070
Huntington DiseaseEpigenetic AlterationsHsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntingtons disease.21421997
Glioblastoma MultiformeEpigenetic AlterationsEpigenetic silencing of the O(6) -methylguanine-DNA methyltransferase (MGMT) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ).21425258
Admitting diagnosisEpigenetic AlterationsThese observations suggest that coordinated transcriptional changes associated with ageing and calcium homeostasis in the human brain are accelerated in patients with AD.21425351
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic Alterations[DNA methylation of tumor suppressor genes located on chromosome 3p in non-small cell lung cancer].21426665
Imprinting (Psychology), AlloisoleucineEpigenetic AlterationsLoss of imprinting (LOI) is an epigenetic alteration involving loss of parental origin-specific expression at normally imprinted genes.21432864
Prostate Cancer PathwayEpigenetic AlterationsThese data provide evidence for a widespread epigenetic field defect in histologically normal tissues that might be employed to identify prostate cancer in patients.21432864
Loss of HeterozygosityEpigenetic AlterationsThe relationship between these polymorphisms and the frequently observed genetic and/or epigenetic aberrations, TP53 loss of heterozygosity (LOH), 1p34 LOH, retinoblastoma-1 (RB1) LOH, p16 inactivation and epidermal growth factor receptor aberrations, was then assessed.21435097
Primary malignant neoplasmEpigenetic AlterationsWe previously identified a functional variant in a let-7 microRNA (miRNA) complementary site in the 3-untranslated region of the KRAS oncogene (rs61764370) which is associated with cancer.21435948
Breast Carcinoma, Triple-Negative Breast Cancer FindingEpigenetic AlterationsThe KRAS variant might be a genetic marker for development of triple-negative breast cancer in premenopausal women, and altered gene and miRNA expression signatures should enable molecular and biological stratification of patients with this subgroup of breast cancer.21435948
Lupus Erythematosus, SystemicEpigenetic AlterationsGenome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus.21436623
Lupus ErythematosusEpigenetic AlterationsWe identified 236 hypomethylated and 105 hypermethylated CG sites in lupus CD4 (+) T cells compared to normal controls, consistent with widespread DNA methylation changes in lupus T cells.21436623
Lupus ErythematosusEpigenetic AlterationsRecent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus.21436623
Primary malignant neoplasmEpigenetic AlterationsAlterations in DNA methylation contribute to cancer development and progression.21438024
Pituitary AdenomaEpigenetic AlterationsIt has been suggested that pituitary adenoma results from accumulation of multiple genetic and/or epigenetic aberrations, which may be identified through association studies.21439054
Communicable Diseases, Skin carcinomaEpigenetic AlterationsHPV-38 was predicted to express an miRNA conserved to human let-7a and the expression of let-7a, in HPV-38-positive non-melanoma skin cancer (NMSC) biopsies was 10-fold higher than those with HPV-positive (for other types except HPV-38) and HPV-negative NMSCs, suggesting that let-7a expression might be related to HPV-38 infection.21442230
Communicable DiseasesEpigenetic AlterationsPotential gene targets of the predicted miRNA that may aid HPV in infection and pathogenesis were also analysed.21442230
Malignant neoplasm of urinary bladderEpigenetic AlterationsReduced levels of global DNA methylation, assessed in peripheral blood, have been associated with bladder cancer risk in European and American populations.21445976
Malignant neoplasm of urinary bladderEpigenetic AlterationsSimilar data are lacking in Asian populations where genetic differences, lifestyle factors and different environmental exposures may affect DNA methylation and its risk relationship with bladder cancer.21445976
MYELODYSPLASTIC SYNDROME, Acute Myeloid Leukemia with Myelodysplasia-Related Changes, Leukemia, Myelocytic, AcuteEpigenetic AlterationsImpaired mitochondrial gene transcription in myelodysplastic syndromes and acute myeloid leukemia with myelodysplasia-related changes.21447369
Congenital contractural arachnodactyly, CholangiocarcinomaEpigenetic AlterationsGenetic changes have been widely reported in association with cholangiocarcinoma (CCA), while epigenetic changes are poorly characterised.21448164
Metastasis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration.21448905
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA microarray profiling was performed on samples from clinically matched NSCLC from seven patients with BM (BM+) and six without BM (BM-).21448905
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe investigated miRNAs that may serve as biomarkers to differentiate between NSCLC patients with and without BM.21448905
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn summary, miR-328 has a role in conferring migratory potential to NSCLC cells working in part through PRKCA and with further corroboration in additional independent cohorts, these miRNAs may be incorporated into clinical treatment decision making to stratify NSCLC patients at higher risk for developing BM.21448905
Squamous cell carcinoma of esophagusEpigenetic AlterationsWith regard to miRNA-processing elements, the expression level of RNASEN was higher in ESCC than in normal epithelium (P < 0.05).21453382
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe findings may imply that miRNA biogenesis is aberrantly accelerated in ESCC.21453382
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma, Hodgkin DiseaseEpigenetic AlterationsEpigenetic changes have been implicated in the loss of the B-cell program in classical Hodgkins lymphoma, and might provide a basis for the immunophenotypic alterations seen in mediastinal gray zone lymphoma.21454882
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma, Hodgkin DiseaseEpigenetic AlterationsBased on the epigenetic profiles we were able to establish class prediction models utilizing genes such as HOXA5, MMP9, EPHA7 and DAPK1 which could distinguish between mediastinal gray zone lymphoma, classical Hodgkins lymphoma and primary mediastinal large B-cell lymphoma with a final combined prediction of 100%.21454882
Pancreatic carcinomaEpigenetic AlterationsLeukocyte DNA methylation signature differentiates pancreatic cancer patients from healthy controls.21455317
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsExpression of microRNAs can affect age of tumor onset and prognosis of cancer patients.21455991
sodium thiosulfate, Sarcoma, Primary malignant neoplasmEpigenetic AlterationsHowever, nothing is known about the effects of microRNAs on altered age of cancer onset and disease-specific survival of soft-tissue sarcoma (STS) patients.21455991
Leukemia, Myelocytic, AcuteEpigenetic AlterationsFunctional implications of microRNAs in acute myeloid leukemia by integrating microRNA and messenger RNA expression profiling.21455993
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe expression of microRNAs (miRNAs) is deregulated in acute myeloid leukemia (AML), but the corresponding functional miRNA-controlled pathways are poorly understood.21455993
LeukemogenesisEpigenetic AlterationsIntegration of messenger RNA (mRNA) and miRNA expression profiling may allow the identification of functional links between the whole transcriptome and microRNome that are involved in myeloid leukemogenesis.21455993
Leukemia, Myelocytic, AcuteEpigenetic AlterationsOur results indicate that by integrating the transcriptome and microRNome in AML cells, it is possible to identify previously unidentified putative functional miRNA-mRNA interactions in AML.21455993
Liver carcinomaEpigenetic AlterationsDeregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma.21458843
Liver carcinomaEpigenetic AlterationsMicroRNA-221, microRNA-222, and microRNA-21 were differentially overexpressed in hepatocellular carcinoma compared with nonneoplastic and normal livers (P < .001).21458843
CarcinomaEpigenetic AlterationsThe mean fold changes in microRNA-221, microRNA-222, and microRNA-21(hepatocellular carcinoma to matched nonneoplastic liver) were 4.00, 4.44, and, 3.67, respectively.21458843
Liver carcinomaEpigenetic AlterationsHigh expression of microRNA-221 in hepatocellular carcinomas was significantly related to shorter time to local recurrence (P < .001) and determined as an independent predictor for local recurrence (P = .001).21458843
Hepatocarcinogenesis, MetastasisEpigenetic AlterationsBased on these results, we propose the possible role of microRNA-221, microRNA-222, microRNA-21, and microRNA-155 dysregulation in hepatocarcinogenesis and the potential of microRNA-221 dysregulation for predicting local recurrence and distant metastasis after curative surgery.21458843
Liver carcinomaEpigenetic AlterationsAberrant expression of specific microRNAs in hepatocellular carcinomas has recently been reported.21458843
CarcinogenesisEpigenetic AlterationsDNA methylation contributes to carcinogenesis by mediating transcriptional regulation and chromatin remodelling, which may influence the effect of DNA-damaging drugs.21458988
ovarian neoplasmEpigenetic AlterationsConsistent with their epigenetic regulation, reduced expression of FZD4, DVL1, and ROCK1 is an indicator of early-disease relapse in an independent ovarian tumor cohort (n = 311, adjusted P < 0.05).21459799
ovarian neoplasmEpigenetic AlterationsThe data highlight the importance of epigenetic regulation of multiple promoter CGIs of Wnt pathway genes in ovarian cancer and identify methylation at NKD1 and DVL1 as independent predictors of PFS.21459799
Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia.21460253
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe levels of several of these circulating miRNAs also displayed significant differences between zeta-associated protein 70 (ZAP-70)(+) and ZAP-70(-) CLL.21460253
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThis hypothesis suggests the possibility of using the levels of specific miRNAs in plasma to detect CLL and to determine the ZAP-70 status.21460253
Primary malignant neoplasmEpigenetic AlterationsAberrant expression of miRNA has been associated with the development or progression of several diseases, including cancer.21460750
Malignant Neoplasms, Virus DiseasesEpigenetic AlterationsMolecular and epidemiological data have unequivocally confirmed that high-risk human papillomaviruses (HPVs) are a major etiological agent of this malignancy, as host epigenetic alterations are induced in response to viral infection.21461574
NeoplasmsEpigenetic AlterationsDifferences in miRNA hypermethylation between the tumor and control samples were highly significant for all the genes tested (p<0.0001).21461574
NeoplasmsEpigenetic AlterationsThe lr-HPV precursor lesions had a methylation percent pattern similar to that of the normal samples, while the results for the hr-HPV precursor lesions and tumors indicate a possible involvement of the hr-HPV genotype in the miRNA methylation process.21461574
Stomach CarcinomaEpigenetic AlterationsClinical significance of expression of Hint1 and potential epigenetic mechanism in gastric cancer.21468541
Malignant neoplasm of urinary bladderEpigenetic AlterationsmicroRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells.21468550
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAbnormal expression of let-7a microRNA (miRNA) in non-small cell lung cancer (NSCLC) cells and tissue has been previously reported.21468581
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAberrant expression of let-7a miRNA in the blood of non-small cell lung cancer patients.21468581
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe 2(-ddCt) of let-7a miRNA in the blood of normal subjects and those with NSCLC was 3242.49+-355.28 and 747.85+-177.74, respectively.21468581
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe 2(-ddCt) of let-7a miRNA in the normal human lung tissues and human NSCLC tissues was 42.30+-3.98 and 27.73+-3.86, respectively.21468581
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLet-7a miRNAs were under-expressed in the blood of NSCLC patients, as well as NSCLC cells and NSCLC tissues, compared to normal controls.21468581
Autoimmune stateEpigenetic AlterationsMicroRNAs (miRNAs), small non-coding RNA molecules that post-transcriptionally regulate gene expression, are known to play key roles in regulating immune responses and autoimmunity.21469088
Childhood MedulloblastomaEpigenetic AlterationsExpression of KCASH2 and -3 is observed in cerebellum, whereas epigenetic silencing and allelic deletion are observed in human medulloblastoma.21472142
CDKN2A NegativeEpigenetic AlterationsThe genetic and epigenetic alterations frequently observed were EGFR amplification (51.5%), TP53 mutation (33.8%), CDKN2A loss (32.4%), TP53 loss (16.2%), methylation of the MGMT promoter (33.8%) and IDH1 mutation (5.9%).21472719
Primary NeoplasmEpigenetic AlterationsAberrant DNA methylation of primary breast tumors can have impact on the clinical outcome.21479925
1-methyl-1-piperidinomethane sulfonateEpigenetic AlterationsmiRNAs isolated from fresh-frozen biopsies of MPM patients were tested for the expression of 88 types of miRNA involved in cancerogenesis.21483773
NeoplasmsEpigenetic AlterationsSince recent data point to abnormal levels of microRNAs (miRNAs) in tumors, we hypothesized that a profile of deregulated miRNAs may be a marker of MPM and that the levels of specific miRNAs may be used for monitoring its progress.21483773
Primary malignant neoplasmEpigenetic AlterationsAs the epigenetics of cancer are unraveled, KLK10 may represent not only a novel biomarker, but also a promising future therapeutic target for the disease.21487810
Prostate Cancer PathwayEpigenetic AlterationsThe expression of 7 miRNAs in LNCaP, LNCaP-AI, and PC3 prostate cancer cell lines was detected by Northern blotting.21487968
Malignant mesotheliomaEpigenetic AlterationsThrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism.21489980
Adenocarcinoma of lung (disorder)Epigenetic AlterationsDNA methylation profile during multistage progression of pulmonary adenocarcinomas.21494759
Adenocarcinoma of lung (disorder)Epigenetic AlterationsMultiple genetic and epigenetic alterations are known to be involved in the carcinogenesis of peripheral pulmonary adenocarcinoma (ADC).21494759
CarcinogenesisEpigenetic AlterationsOur results indicate that epigenetic alterations are involved in the multistep progression of pulmonary ADC development, and aberrant CpG island methylation accumulates during multistep carcinogenesis.21494759
Invasive LesionEpigenetic AlterationsIn addition, aberrant methylation of HOXA1, TMEFF2, and RARB occurred in preinvasive lesions, which indicates that epigenetic alterations of these genes are involved in the early stages of pulmonary ADC development.21494759
Myeloid Leukemia, ChronicEpigenetic AlterationsEpigenetic regulation of cathepsin L expression in chronic myeloid leukaemia.21496199
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsDo DNA-methylation and histone acetylation play a role in clear cell renal carcinoma?21496397
NeoplasmsEpigenetic AlterationsThe percentage of global DNA methylation was significantly higher in grades 3 and 4 tumors (p=0.033).21496397
Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA; miR) is a class of small regulatory RNA molecules, the aberrant expression of which can lead to the development of cancer.21502955
Neoplastic diseaseEpigenetic AlterationsLeukemic mutations in all four genes have recently been implicated in aberrant DNA methylation, a hallmark of neoplasia.21504050
CarcinogenesisEpigenetic AlterationsThese evidences held the role of oncosuppressor methylation in both colon tumorigenesis and progression and suggested that epigenetic events should be taken into account when biological therapies in mCRC patients have to be set.21506124
Malignant tumor of colonEpigenetic AlterationsDNA methylation predicts recurrence from resected stage III proximal colon cancer.21509761
Clinical Coordinator, teratologic, Colorectal Cancer PathwayEpigenetic AlterationsIn colorectal cancer (CRC), DNA methylation anomalies define distinct subgroups termed CpG island methylator phenotype 1 (CIMP1), CIMP2, and CIMP-negative.21509761
Clinical CoordinatorEpigenetic AlterationsDNA methylation is a useful biomarker of recurrence in resected stage III proximal but not distal CRC.21509761
Breast CarcinomaEpigenetic AlterationsMicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11.21510944
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNAs are widely dysregulated in various cancers and integrated into tumorigenic programs as either oncogenes or tumor suppressor genes.21510944
Primary NeoplasmEpigenetic AlterationsWe initially compared whole-genome patterns of DNA methylation among 24 OPSCC primary tumors and 24 matched normal mucosal samples.21514414
NeoplasmsEpigenetic AlterationsFrom a survey of 27,578 CpG dinucleotide loci spanning more than 14,000 genes, we identified 958 CpG loci in which measurements of DNA methylation were altered in the primary tumors relative to the normal mucosal samples.21514414
Oropharyngeal CarcinomaEpigenetic AlterationsThis study reports the epigenetic silencing of Kruppel-type zinc finger protein genes on chromosome 19q13 in oropharyngeal cancer.21514414
Malignant neoplasm of urinary bladder, Best Case Imputation TechniqueEpigenetic AlterationsHowever, the genetic or epigenetic regulations of these miRNAs have not yet been fully elucidated in bladder cancer (BC).21519788
Malignant Neoplasms, Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsGrowing evidence suggests that microRNAs (miRNAs) are aberrantly expressed in many human cancers, and that they play significant roles in carcinogenesis and cancer progression.21519788
Carcinogenesis, NeoplasmsEpigenetic AlterationsThe identification of tumor suppressive miRNAs and their target genes could provide new insights into the mechanism of carcinogenesis.21519788
Mental disordersEpigenetic AlterationsThe genetic, epigenetic and environmental factors may influence the risk for neuropsychiatric disease through their effects on gene transcription.21521424
Primary malignant neoplasmEpigenetic AlterationsEpigenetic changes in the methylation of the RUNX3 proximal promoter, but not common genetic changes in RUNX3, have been associated with both changes in the gene expression and development of the cancer.21523770
Stomach CarcinomaEpigenetic AlterationsIn addition to epigenetic changes in the RUNX3 proximal promoter, genetic changes in the distal promoter may be associated with susceptibility to intestinal-type gastric cancer by increasing promoter activity.21523770
Non-Small Cell Lung CarcinomaEpigenetic AlterationsPGIS mRNA expression was regulated by DNA CpG methylation and histone acetylation in NSCLC cell lines, with chromatin remodeling taking place directly at the PGIS gene.21523772
Non-Small Cell Lung CarcinomaEpigenetic AlterationsProstacyclin synthase expression and epigenetic regulation in nonsmall cell lung cancer.21523772
Diffuse Large B-Cell LymphomaEpigenetic AlterationsThe expression of specific miRNAs may be useful for DLBCL survival prediction and their role in the pathogenesis of this disease should be examined further.21525173
Sezary SyndromeEpigenetic AlterationsMicroRNA profiling reveals that miR-21, miR486 and miR-214 are upregulated and involved in cell survival in Sezary syndrome.21525938
MetastasisEpigenetic AlterationsMicroRNA profiling may be particularly helpful in patients in whom the IHC profile of the metastasis is nondiagnostic or leaves a large differential diagnosis.21531815
NeoplasmsEpigenetic AlterationsAlthough microRNAs regulate all the major biological mechanisms, their influence on tumor microenvironment is largely unexplored.21532615
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsThese results suggest the possible implication of BRCA1 promoter methylation in the early onset of breast cancer and propose the use of this epigenetic modification as a powerful molecular marker for detecting women potentially predisposed to cancer.21537840
Papillary thyroid carcinomaEpigenetic AlterationsMicroRNA signature distinguishes the degree of aggressiveness of papillary thyroid carcinoma.21537871
F9 geneEpigenetic AlterationsmiRNA array was used to identify a subset of differentially expressed miRNAs between aggressive and nonaggressive PTC.21537871
F9 geneEpigenetic AlterationsThe miRNA array identified miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.21537871
F9 geneEpigenetic AlterationsSignificant miRNA deregulation was confirmed in the validation cohort, with upregulation of miR-146b and miR-222 and downregulation of miR-34b and miR-130b seen in aggressive PTC.21537871
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are dysregulated in various tumors types, and some of them serve as markers of poor prognosis.21537871
methionine, F9 gene, Neoplasms, ret/PTCEpigenetic AlterationsThese miRNAs were further validated by real-time RT-PCR in a cohort of 17 PTC with local tumor recurrence or distant metastases and 15 PTC with no extrathyroidal dissemination and correlated with BRAF, RAS, and RET/PTC mutations and MET expression.21537871
methionine, F9 geneEpigenetic AlterationsMET was identified as a potential target gene for 2 downregulated miRNAs (miR-34b and miR-1), and significantly higher level of MET expression was observed in aggressive PTC.21537871
Colorectal CarcinomaEpigenetic Alterations[MicroRNA-221 controls CDKN1C/P57 expression in human colorectal carcinoma].21538272
NeoplasmsEpigenetic AlterationsThe role of microRNA-155 (miR-155) has been associated with oncogenesis of several human tumors.21541331
Colorectal NeoplasmsEpigenetic AlterationsOur results suggest that analysis of the methylation of DNA in mucosal wash fluid may be a good molecular marker for predicting the invasiveness of colorectal tumors.21543345
Colorectal NeoplasmsEpigenetic AlterationsEpigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors.21543345
Hematologic NeoplasmsEpigenetic AlterationsEpigenetic inactivation of the miR-124-1 in haematological malignancies.21544199
CarcinogenesisEpigenetic AlterationsEpigenetic deregulation of miRs is implicated in carcinogenesis.21544199
NeoplasmsEpigenetic AlterationsmiR-124-1 is a tumour suppressor microRNA (miR).21544199
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCirculating micro-RNA expression profiles in early stage nonsmall cell lung cancer.21544802
Carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsCirculating micro-RNA (miR) profiles have been proposed as promising diagnostic and prognostic biomarkers for cancer, including lung cancer.21544802
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-21 and PDCD4 expression in colorectal cancer.21546206
Malignant tumor of colonEpigenetic AlterationsThis study was designed to determine whether DNA methylation biomarkers are associated with recurrence and survival in colon cancer patients.21551253
Stomach CarcinomaEpigenetic AlterationsStem cell associated genes working with one miRNA cluster have different clinic pathologic values in gastric cancer.21553350
Liver carcinomaEpigenetic AlterationsUnderexpressed microRNA-199b-5p targets hypoxia-inducible factor-1a in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients.21557766
ovarian neoplasmEpigenetic AlterationsPeripheral blood DNA methylation detected in the BRCA1 or BRCA2 promoter for sporadic ovarian cancer patients and controls.21557934
ovarian neoplasmEpigenetic AlterationsIn most of sporadic ovarian cancer, variation in the expression of BRCA1 and BRCA2 genes was observed and it could be a consequence of epigenetic modifications.21557934
ovarian neoplasmEpigenetic AlterationsThese results may have implications in better understanding the underlying epigenetic mechanisms in BRCA1 and BRCA2 oncosuppressors in sporadic ovarian cancer.21557934
Glioblastoma MultiformeEpigenetic AlterationsA specific miRNA signature in the peripheral blood of glioblastoma patients.21561454
Glioblastoma MultiformeEpigenetic AlterationsTo this end, miRNA profiles from the blood of 20 patients with glioblastoma and 20 age- and sex-matched healthy controls were compared.21561454
Stomach CarcinomaEpigenetic AlterationsEpigenetic regulation of microRNA-10b and targeting of oncogenic MAPRE1 in gastric cancer.21562367
CarcinogenesisEpigenetic AlterationsMicroRNAs act as negative regulators of gene expression, and the altered expression of microRNAs by epigenetic mechanisms is strongly implicated in carcinogenesis.21562367
Stomach CarcinomaEpigenetic AlterationsHere we report that the microRNA-10b gene (miR-10b) was silenced in gastric cancer cells by promoter methylation.21562367
Secondary malignant neoplasm of rectumEpigenetic AlterationsMicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility.21562850
Malignant Neoplasms, Breast Carcinoma, MetastasisEpigenetic AlterationsHuman microRNA-9 (miR-9) has been reported to be involved in the metastasis of several malignancies including brain breast cancer.21562850
Primary malignant neoplasmEpigenetic AlterationsAltered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy.21567082
Colorectal CarcinomaEpigenetic AlterationsmiRNA-21 (miR-21) is upregulated and miR-143 and miR-145 are downregulated in colorectal carcinoma.21567082
NeoplasmsEpigenetic AlterationsAccording to the predictive and prognostic value of the analyzed miRNAs, a significant correlation between miR-145 expression and tumor regression was seen.21567082
ovarian neoplasmEpigenetic AlterationsMicroRNA let-7a: a potential marker for selection of paclitaxel in ovarian cancer management.21571355
Prostate Cancer PathwayEpigenetic AlterationsEFEMP1 as a novel DNA methylation marker for prostate cancer: array-based DNA methylation and expression profiling.21571867
Prostatic Hyperplasia, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsDNA methylation and gene expression analysis in 203 human prostate specimens, including 106 PCa and 97 benign prostate hyperplasia (BPH), were carried out.21571867
Clinical CoordinatorEpigenetic AlterationsThe selected candidate prognostic miRNAs were validated in a cohort of 50 CRC patients by TaqMan quantitative PCR.21573504
Renal Cell Carcinoma PathwayEpigenetic AlterationsGermline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma.21584899
Somatic, Primary malignant neoplasmEpigenetic AlterationsIn summary, we have identified KILLIN as a potential novel cancer predisposition gene for nonsyndromic clear-cell RCC, and the epigenetic mechanism of KILLIN inactivation in both the germline and somatic setting suggests the potential for treatment with demethylating agents.21584899
Infection caused by Helicobacter pylori, Stomach CarcinomaEpigenetic AlterationsGenome-wide DNA methylation profiles in noncancerous gastric mucosae with regard to Helicobacter pylori infection and the presence of gastric cancer.21585603
Communicable Diseases, Helicobacter pyloriEpigenetic AlterationsTo determine genome-wide DNA methylation profiles induced by Helicobacter pylori (H. pylori) infection and to identify methylation markers in H. pylori-induced gastric carcinogenesis.21585603
Carcinoma of lungEpigenetic AlterationsThese findings suggest that DNA methylation may be important for downregulation of CFTR gene expression in lung cancer.21585618
Ventricular hypertrophy, Aortic Valve StenosisEpigenetic AlterationsMyocardial gene expression of microRNA-133a and myosin heavy and light chains, in conjunction with clinical parameters, predict regression of left ventricular hypertrophy after valve replacement in patients with aortic stenosis.21586423
Clinical Coordinator, Colorectal NeoplasmsEpigenetic AlterationsWnt5a is a critical regulator of non-canonical Wnt activity and promoter hypermethylation of this gene has emerging prognostic roles in CRC; however the frequency and prognostic significance of this epigenetic event have not been explored in the context of colorectal tumour subtype.21587258
Clinical Coordinator, NeoplasmsEpigenetic AlterationsMethylation of Wnt5a is associated with distinct tumour subtypes, strengthening the evidence of an epigenetic-mediated Wnt bias in CRC.21587258
Multiple MyelomaEpigenetic AlterationsMicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival.21592325
Malignant NeoplasmsEpigenetic AlterationsA comparison of these microRNAs with those aberrantly expressed in other B-cell and T-cell malignancies revealed a surprising degree of similarity (~40%) suggesting the existence of a common lymphoma microRNA signature.21592325
Malignant Neoplasms, Hematologic NeoplasmsEpigenetic AlterationsMicroRNAs are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many cancers including hematological malignancies.21592325
Multiple Myeloma, Morular Metaplasia of the EndometriumEpigenetic AlterationsHowever, the role of microRNAs in the pathogenesis of multiple myeloma (MM) is only poorly understood.21592325
Monoclonal Gammopathy of Undetermined SignificanceEpigenetic AlterationsWe identified 39 microRNAs associated with the pre-malignant condition MGUS.21592325
Multiple MyelomaEpigenetic AlterationsAdditionally, we identified microRNAs associated with light chain only myeloma, as well as IgG and IgA-type MM.21592325
Primary malignant neoplasmEpigenetic AlterationsThus, DNA methylation analysis is expected to be a new tool for cancer diagnosis.21594664
Malignant neoplasm of urinary bladder, Primary malignant neoplasmEpigenetic AlterationsDistinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine.21599969
Arteriosclerosis, Cardiovascular DiseasesEpigenetic AlterationsSNPs in miRNA-processing genes may modify associations between ambient pollution and sICAM-1 and sVCAM-1, which are correlates of atherosclerosis and cardiovascular disease.21600003
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is a promising biomarker for cancer.21600201
SF3B1 wt AlleleEpigenetic AlterationsThe distributions of these 2 miRNA levels were bimodal in MDS patients, and these levels were significantly associated with their progression-free survival and overall survival (both P < .001 for let-7a; P < .001 and P = .001 for miR-16).21602527
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsCirculating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndrome.21602527
Primary malignant neoplasmEpigenetic AlterationsCirculating microRNAs (miRNAs) are potential biomarkers for cancer.21602527
SF3B1 wt AlleleEpigenetic AlterationsCirculating levels of both miRNAs were similar among healthy controls but were significantly lower in MDS patients (P = .001 and P < .001, respectively).21602527
melanomaEpigenetic AlterationsUse of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma.21606880
NeoplasmsEpigenetic AlterationsMicroRNA-146a downregulates NFkB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma.21610143
SCYL1 geneEpigenetic AlterationsWe measured miRNA expression in NKTL tissues and cell lines, using real-time PCR, and analyzed its role in NKTL, using cell lines.21610143
Carcinoma of lungEpigenetic AlterationsWe then tested this 15-gene set to identify the more useful DNA methylation changes in the serum of a limited number of lung cancer patients and controls.21610147
Carcinoma of lungEpigenetic AlterationsAn epigenetic marker panel for detection of lung cancer using cell-free serum DNA.21610147
Non-Small Cell Lung CarcinomaEpigenetic AlterationsFrequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer.21610322
Carcinoma of lungEpigenetic AlterationsIn addition identifying patients with KEAP1 genetic and epigenetic abnormalities may contribute to disease progression prediction and response to therapy in lung cancer patients.21610322
Renal Cell Carcinoma PathwayEpigenetic AlterationsPolycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma.21610323
Renal Cell Carcinoma, Refractory Cytopenia of ChildhoodEpigenetic AlterationsHere, we defined profiles of DNA methylation in primary renal cell carcinomas (RCC) and assessed the association of these profiles with the expression of genes required for the establishment and maintenance of epigenetic marks.21610323
Nerve Degeneration, Huntington DiseaseEpigenetic AlterationsThese findings suggest that other genetic, epigenetic, and environmental factors play important roles in neurodegeneration in Huntingtons disease.21611979
Primary malignant neoplasmEpigenetic AlterationsGenome-wide alterations in DNA methylation are a common event in cancer.21615918
Concomitant Medication Submission DomainEpigenetic AlterationsOverall level of genomic DNA methylation was measured using bisulfite pyrosequencing at three CpG sites (CpG1, CpG2, CpG3) of the Long Interspersed Nucleotide Element-1 (LINE-1) sequences in short-term CM cultures from 42 stage IIIC patients.21615918
Carcinoma of lungEpigenetic AlterationsThe microRNA (miRNA) miR-196a2 may play an important role in lung cancer development and survival by altering binding activity of target mRNA.21617338
Breast CarcinomaEpigenetic AlterationsMicroRNA miR-335 is crucial for the BRCA1 regulatory cascade in breast cancer development.21618216
Breast CarcinomaEpigenetic AlterationsDeregulation of the microRNA during breast cancer development and progression may thereby lead to an increased tumorigenic potential by inactivating crucial tumor-suppressive signals.21618216
Cerebral IschemiaEpigenetic AlterationsMicroRNA-210 as a novel blood biomarker in acute cerebral ischemia.21622133
IschemiaEpigenetic AlterationsMicroRNA-210 (miR-210), a master and pleiotropic hypoxia-microRNA, plays multiple roles in brain ischemia.21622133
Cerebrovascular accidentEpigenetic AlterationsCompared to healthy controls, blood miRNA-210 was significantly decreased in stroke patients (0.93 vs. 1.36; P=0.001), especially at 7 days (0.56 vs. 1.36; P=0.001) and 14 days of stroke onset (0.50 vs. 1.36; P=0.001).21622133
Admitting diagnosis, MIRLET7F1 wt AlleleEpigenetic AlterationsmiRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens (all P < .05; t test).21622546
Adenocarcinoma, Neoplasms, Admitting diagnosis, Squamous cell carcinoma, SERPINB3 wt AlleleEpigenetic AlterationsMicroRNAs (miRNAs) are small noncoding genes recently reported as useful in differentiating squamous cell carcinoma (SCC) from adenocarcinoma (AD) in resected tumor specimens.21622546
Metastasis, Familial medullary thyroid carcinomaEpigenetic AlterationsMicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis, and potential therapeutic targets.21622722
Magnetic-Targeted Carriers, Primary malignant neoplasmEpigenetic AlterationsIn addition, microRNAs (miRNAs) have been shown to be important diagnostic and prognostic markers in cancer but have not been defined in MTC.21622722
Magnetic-Targeted CarriersEpigenetic AlterationsOur data indicate that miRNAs play a pivotal role in the biology of MTC and represent an important class of prognostic biomarkers and therapeutic targets warranting further investigation.21622722
Carcinoma of larynxEpigenetic Alterations[DNA methylation and histone modification relate to RASSF1A gene deletion in laryngeal carcinoma tissues].21624251
Carcinoma of larynxEpigenetic AlterationsChromatin immunoprecipitation (ChIP), methylation specific polymerase chain reaction (MSP) and realtime quantitative reverse transcription polymerase chain reaction (realtime RT-PCR) were used to analyze RASSF1A gene promoter region histone H3 lysine 9 methylation, H3 lysine 4 methylation, H3 lysine 9 acetylation, DNA methylation, and RASSF1A gene expression in laryngeal carcinoma tissue of 50 cases.21624251
Carcinoma of larynxEpigenetic AlterationsDNA methylation rate of gene RASSF1A was 62% in 50 cases of laryngeal carcinoma, but no DNA methylation was found in normal control group, with a significant difference (kh(2) = 15.381, P < 0.05).21624251
MetastasisEpigenetic AlterationsDNA methylation had no correlation with age, gender, differentiation degree, T stage, pathological type and lymph node metastasis (P > 0.05).21624251
AffectionEpigenetic AlterationsThe affection of DNA methylation group was more than unmethylation group to expression of gene RASSF1A (t = -3.108, P < 0.01).21624251
Carcinoma of larynxEpigenetic AlterationsThere was positive correlation between RASSF1A deletion and gene hypermethylation or between H3 lysine 9 methylation of RASSF1A gene promoter and DNA methylation in laryngeal carcinoma tissue(r = 0.816, P < 0.05), but there was negative correlation between H3 lysine 4 methylation of RASSF1A gene promoter and DNA methylation (r = -0.837, P < 0.05) and no correlation between H3 lysine 9 acetylation and DNA methylation (r = -0.383, P > 0.05).21624251
NeoplasmsEpigenetic AlterationsLaryngeal tumor suppressor gene RASSF1A promoter methylation is a key factor down-regulating the gene expression, and histone modifications also plays an important role in tumor development.21624251
Malignant neoplasm of urinary bladderEpigenetic Alterations*Global histone modification levels (H3K4me1, H3K4me3, H4K20me1, H4K20me2, and H4K20me3) were lower in bladder cancer samples than in NU tissue *Global levels of H3K4me1, H4K20me1, H4K20me2 and H4K20me3 were decreasing from NU over NMIBC and MIBC to METS.21627749
Malignant neoplasm of urinary bladderEpigenetic Alterations*To determine the role of global histone methylation as a prognostic parameter in patients with bladder cancer.21627749
Malignant neoplasm of urinary bladderEpigenetic Alterations*Global histone methylation levels may help to identify patients with bladder cancer with poor prognosis after radical cystectomy.21627749
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIdentification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer.21627863
Malignant NeoplasmsEpigenetic AlterationsMicroRNA profiling for the identification of cancers with unknown primary tissue-of-origin.21630269
Malignant NeoplasmsEpigenetic AlterationsThese results establish that FFPE samples can be used to reveal the tissue of origin of metastatic cancers by using microRNA expression profiling and suggest that the approach, if applied, could provide strong indications for CUPs, whose correct diagnosis is presently undefined.21630269
Glioma, NeoplasmsEpigenetic AlterationsDNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas.21631628
Malignant GliomaEpigenetic AlterationsTaken together, our findings demonstrate that both 5-CpG island hypermethylation and histone modifications contribute to the frequent and prognostically unfavorable transcriptional downregulation of RRP22 in malignant gliomas.21631628
Toxicity aspects, Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsGiven that dysregulation of hepatic microRNA expression has been observed in NAFLD, we examined the role of miRNA in regulating PUMA expression during lipotoxicity.21633093
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsDNA hypermethylation is a common epigenetic abnormality in colorectal cancers (CRCs) and a promising class of CRC screening biomarkers.21636702
Malignant Head and Neck NeoplasmEpigenetic AlterationsDifferential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers.21637912
Malignant Head and Neck NeoplasmEpigenetic AlterationsUntil now, there are no data published on the miRNA expression in head and neck cancers from Malaysia.21637912
Primary malignant neoplasmEpigenetic AlterationsDiverse studies on expression profiling of miRNAs have been performed and the data showed that some miRNAs are up-regulated or down-regulated in cancer.21637912
Malignant Head and Neck NeoplasmEpigenetic AlterationsThese miRNAs may contribute in a simple profiling strategy to identify individuals at higher risk of developing head and neck cancers, thus helping in the elucidation of the molecular mechanisms involved in head and neck cancer pathogenesis.21637912
Hypoxia, Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn summary, neuroglobin and myoglobin overexpression in NSCLC is associated with histological subtype, hypoxia and, in case of neuroglobin - epigenetic regulation.21640426
Malignant neoplasm of breastEpigenetic AlterationsWe broadly profiled DNA methylation in breast cancers (n = 351) and benign parenchyma (n = 47) for correspondence with disease phenotype, using FFPE diagnostic surgical pathology specimens.21641572
Malignant NeoplasmsEpigenetic AlterationsHowever, genetic and epigenetic alterations of SIP1 have not been fully elucidated in cancers.21645397
Hollings Cancer CenterEpigenetic AlterationsEpigenetic mechanisms contribute significantly to the downregulation of SIP1 expression in HCC.21645397
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNA) are noncoding regulatory RNAs involved in initiation and progression of human cancers.21652542
Primary malignant neoplasmEpigenetic AlterationsIn 10 resected PDAC samples, miR-10b was the most frequently and consistently overexpressed miRNA among characterized miRNAs, exhibiting a four-fold increase in the cancer cells (P = 0.012).21652542
Carcinoma of lung, Lung NeoplasmsEpigenetic AlterationsIn a comprehensive evaluation of EBV miRNA, DNA, RNA, and protein in lung cancer, we found little evidence of EBV in lung tumour tissue.21654679
Carcinoma of lungEpigenetic AlterationsEpstein-Barr virus microRNAs and lung cancer.21654679
NeoplasmsEpigenetic AlterationsWe tested for EBV DNA, RNA, and protein in tumour tissue from six cases with and six cases without strong qPCR-based evidence of EBV miRNAs.21654679
NeoplasmsEpigenetic AlterationsAlthough qPCR provided substantial evidence of EBV miRNAs in 7 out of 48 cases, only 1 of these 7 cases had detectable EBV DNA in tumour tissue.21654679
Stage I Esophageal Squamous Cell Carcinoma AJCC v7Epigenetic AlterationsThe oncogenetic role of microRNA-31 as a potential biomarker in oesophageal squamous cell carcinoma.21658006
Malignant NeoplasmsEpigenetic AlterationsmiR-31 (microRNA-31) is frequently altered in numerous cancers.21658006
Pancreatic carcinomaEpigenetic AlterationsOur study suggests that the mismatch repair genes play an important role in pancreatic cancer carcinogenesis and progression through epigenetic modification, and it may be regarded as a potential target for the management of pancreatic cancer.21660619
Multiple MyelomaEpigenetic AlterationsmiR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma.21664042
NeoplasmsEpigenetic AlterationsThe deregulation of miRNAs expression contributes to tumorigenesis by modulating oncogenic and tumor suppressor signaling pathways.21664042
Multiple MyelomaEpigenetic AlterationsThese results suggest the Myc-inducible miR-17-92 cluster miRNAs contribute to tumorigenesis and poor prognosis in multiple myeloma.21664042
NeoplasmsEpigenetic AlterationsDNA methylation analyses of mir-345 showed high methylation levels in tumor versus normal tissues.21665895
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer.21665895
Clinical CoordinatorEpigenetic AlterationsHere, we investigated CpG island promoter hypermethylation as a potential mechanism underlying miRNA disruption and identifed methylation-sensitive miRNAs that might repress CRC development.21665895
Clinical CoordinatorEpigenetic AlterationsThe candidate miRNA was transfected into CRC cells and growth-suppressive mechanisms were explored.21665895
Clinical CoordinatorEpigenetic AlterationsThese results suggested as a methylation-sensitive miRNA in CRC, mir-345 may play an important role of antineoplastic as a growth inhibitor in the development of CRC.21665895
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have been found deregulated in human colorectal cancer (CRC), and some of them may function as tumor suppressor genes.21665895
NeoplasmsEpigenetic AlterationsInitial screening established a profile of aberrantly expressed miRNAs in tumors.21666718
Malignant tumor of colon, NeoplasmsEpigenetic AlterationsTranscription and external cell signaling factors are altered as covariates to COX-2 expression in colon cancer tissue, but DNA methylation of the COX-2 promoter region was not a significant factor behind COX-2 expression in tumor and normal colon tissue.21668942
CarcinogenesisEpigenetic AlterationsIn a network analysis, chromatin modifications were linked to 11 significantly modulated histone genes, pointing towards a possible epigenetic mechanism that may be relevant in comprehending NOC-induced carcinogenesis.21669488
Colorectal CarcinomaEpigenetic Alterations[DNA methylation of ZIC1 and KLOTHO gene promoters in colorectal carcinomas and its clinicopathological significance].21671493
Colorectal CarcinomaEpigenetic AlterationsTo determine DNA methylation status of ZIC1 and KLOTHO gene in colorectal carcinomas and its relationship with clinicopathological features of patients.21671493
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsDetection of circulating miRNAs might provide new complementary tumour markers for ESCC.21673684
Small cell carcinoma of lungEpigenetic AlterationsGenetic variation in an miRNA-1827 binding site in MYCL1 alters susceptibility to small-cell lung cancer.21676885
Primary malignant neoplasmEpigenetic AlterationsGenetic variations in microRNAs (miRNA) that affect control of their target genes may alter individual susceptibilities to cancer.21676885
Small cell carcinoma of lungEpigenetic AlterationsOur findings define a 3-UTR SNP in the human L-MYC oncogene that may increase susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827.21676885
Injury of kidneyEpigenetic AlterationsRenal kallikrein excretion and epigenetics in human acute kidney injury: expression, mechanisms and consequences.21679467
Kidney Failure, AcuteEpigenetic AlterationsTherefore we first examined KLK1 renal excretion in human AKI, and then probed potential endocrine and epigenetic mechanisms for its alterations.21679467
Kidney Failure, AcuteEpigenetic AlterationsEpigenetic changes at KLK1 may also play a role in early changes of KLK1 expression and thus AKI susceptibility or recovery.21679467
Malignant neoplasm of urinary bladderEpigenetic AlterationsBladder cancer cells illustrate major disruptions in their DNA methylation patterns as compared with normal ones.21680534
Malignant neoplasm of urinary bladderEpigenetic AlterationsAuthors aimed to identify epigenetic molecular markers in urine for early detection of bladder cancer.21680534
Malignant neoplasm of urinary bladderEpigenetic AlterationsWe tested the epigenetic silencing hypothesis and evaluated the biological influence of KISS1 methylation on its expression and clinical relevance in bladder cancer.21683672
Malignant neoplasm of urinary bladderEpigenetic AlterationsKISS1 hypermethylation was identified in bladder cancer, providing a potential mechanistic explanation (epigenetic silencing) for the observed loss of KISS1 in uroepithelial malignancies.21683672
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are a recently discovered class of small non-coding RNAs that regulate gene expression and may contribute to the development and progression of many cancers.21684154
Endocrine System DiseasesEpigenetic AlterationsThe etiopathogenesis of the trait is a matter of debate and ranges from genetic predisposition to epigenetic, while endocrine disturbances, aging, and dietary factors are also listed among the causes.21684729
PsoriasisEpigenetic AlterationsConsidering that two main characteristics of psoriasis are keratinocytes hyperproliferation and abnormal skin differentiation, we hypothesized that aberrant microRNA expression contributes to the psoriatic phenotype.21687694
MIRN99a microRNA, humanEpigenetic AlterationsMiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R.21687694
MIRN99a microRNA, humanEpigenetic AlterationsFourteen differentially expressed microRNAs were identified, including hsa-miR-99a, hsa-miR-150, hsa-miR-423 and hsa-miR-197.21687694
CarcinogenesisEpigenetic AlterationsThese findings suggest that both processes stem from the same epigenetic and genetic events occurring at an early stage in colon carcinogenesis in AAs.21687703
Cytomegalovirus Infections, Hypertensive diseaseEpigenetic AlterationsSignature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection.21690488
Cytomegalovirus Infections, Hypertensive disease, Hypertensive (finding)Epigenetic AlterationsWe report for the first time a circulating miRNA profile for hypertensive patients and demonstrate a novel link between HCMV infection and essential hypertension.21690488
Hypertensive diseaseEpigenetic AlterationsHowever, little is known about the roles of miRNAs in essential hypertension.21690488
Malignant NeoplasmsEpigenetic AlterationsDifferent microRNAs have been shown to have oncogenic and tumor-suppressive functions in human cancers.21692045
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is a fundamental epigenetic event associated with physiologic and pathologic conditions, including cancer.21692051
NeoplasmsEpigenetic AlterationsThe authors analyzed 16 matched normal and tumor tissues for aberrant DNA methylation using the methylated CpG island amplification and microarray method and the pyrosequencing technique.21692051
Malignant NeoplasmsEpigenetic AlterationsIt has been suggested that the presence of single-nucleotide polymorphisms in precursor miRNAs (pre-miRNAs) can alter miRNA processing, expression, and/or binding to target mRNA and represent another type of genetic variability that can contribute to the development of human cancers.21692953
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are an abundant class of small nonprotein-coding RNAs with posttranscriptional regulatory functions as tumour suppressors and oncogenes.21692953
Primary malignant neoplasmEpigenetic AlterationsAberrant expression and structural alteration of miRNAs are thought to participate in tumourigenesis and cancer development.21692953
Prostate Cancer PathwayEpigenetic AlterationsAbsolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing.21694441
Prostate Cancer Pathway, Carcinogenesis, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsAberrant DNA methylation plays a pivotal role in carcinogenesis and its mapping is likely to provide biomarkers for improved diagnostic and risk assessment in prostate cancer (PCa).21694441
Carcinoma of lungEpigenetic AlterationsSHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma.21694641
Carcinoma of lungEpigenetic AlterationsRecently, analysis of DNA methylation of the SHOX2 locus was shown to reliably identify lung cancer in bronchial aspirates of patients with disease.21694641
Lung diseasesEpigenetic AlterationsDNA methylation of SHOX2 could be used as a biomarker to distinguish between malignant lung disease and controls at a sensitivity of 60% (95% confidence interval: 53-67%) and a specificity of 90% (95% confidence interval: 84-94%).21694641
Carcinoma of lung, Lung diseasesEpigenetic AlterationsSHOX2 DNA methylation is a biomarker for detecting the presence of malignant lung disease in blood plasma from patients with lung cancer.21694641
HyperhomocysteinemiaEpigenetic AlterationsFolic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia.21697534
HomocysteinemiaEpigenetic AlterationsHowever, the reduction in homocysteinemia and the increased availability of methyl compounds provided by vitamin supplementation may not be sufficient to affect genomic DNA methylation.21697534
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsWe demonstrate a distinct and rapid increase in levels of cardiospecific miRNA in the circulation after myocardial infarction.21701171
NecrosisEpigenetic AlterationsRelease of miRNAs correlated with cardiomyocyte necrosis markers, the ejection fraction, and the GFR, indicating a possible role for these molecules as biomarkers for the diagnosis of STEMI as well as the prediction of long-term complications.21701171
Primary malignant neoplasmEpigenetic AlterationsWe focused on the functional significance of miR-1 and miR-133a in cancer cells and identification of the novel cancer networks regulated by these miRNAs in MSSCC.21701775
Primary malignant neoplasmEpigenetic AlterationsRestoration of downregulated miRNAs (miR-1 or miR-133a) in cancer cells revealed that both miRNAs significantly inhibited cancer cell proliferation and induced cell apoptosis.21701775
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2-deoxycytidine (5-aza-CdR) and determined the expressions of the 55 miRNAs.21702040
Carcinoma of lungEpigenetic AlterationsThe DNA methylation of mir-34b can be used as a biomarker for an invasive phenotype of lung cancer.21702040
Non-Small Cell Lung CarcinomaEpigenetic AlterationsGenome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer.21702040
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miRNA) expression is frequently altered in human cancers.21702040
Non-Small Cell Lung CarcinomaEpigenetic AlterationsTo search for epigenetically silenced miRNAs in non-small-cell lung cancer (NSCLC), we mapped human miRNAs on autosomal chromosomes and selected 55 miRNAs in silico.21702040
Primary malignant neoplasmEpigenetic AlterationsFourteen miRNAs were decreased in the cancer cell lines and were induced after 5-aza-CdR treatment.21702040
SF3B1 wt AlleleEpigenetic AlterationsThis study identifies microRNAs (miRNA) and miRNA targets that might represent diagnostic markers for MDS.21703983
SF3B1 wt AlleleEpigenetic AlterationsA discovery set of 20 frozen bone marrow mononuclear cell samples (10 MDS, 10 controls) was profiled on a custom Agilent miRNA microarray.21703983
SF3B1 wt AlleleEpigenetic AlterationsTarget prediction identified potential targets of miRNA regulation that correspond to many of the genes that characterize MDS.21703983
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsDiagnostic microRNAs in myelodysplastic syndrome.21703983
SF3B1 wt AlleleEpigenetic AlterationsClassifier miRNAs were validated in a separate set of 49 paraffin-embedded particle preparations by real-time polymerase chain reaction (24 MDS, 25 controls).21703983
SF3B1 wt AlleleEpigenetic AlterationsOur data utilize both discovery and validation sets and two complementary platforms to identify miRNAs associated with MDS.21703983
Prostate Cancer PathwayEpigenetic AlterationsWe found that global DNA methylation was low in most prostate cancer compared with benign regions from the same patients sections.21704537
Hepatitis B, Malignant neoplasm of liverEpigenetic AlterationsEpigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer.21706058
Colorectal Carcinoma, Carcinogenesis, AdenocarcinomaEpigenetic AlterationsEpigenetic silencing of the DNA mismatch repair genes has been poorly described in colorectal carcinomas showing the classic adenoma-carcinoma pathway of carcinogenesis.21706233
Gastrointestinal Stromal TumorsEpigenetic AlterationsAberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour.21708825
Gastrointestinal Stromal SarcomaEpigenetic AlterationsAdditionally, genome-wide DNA methylation profiles were compared between small, malignant-prone, and malignant GISTs using methylated GpG island amplification microarrays (MCAM) in a training set (n=40).21708825
Gastrointestinal Stromal TumorsEpigenetic AlterationsOur results suggest that GIST is not, in epigenetic terms, a uniform disease and that DNA methylation in a set of genes is associated with aggressive clinical behavior and unfavorable prognosis.21708825
Aggressive behavior, Gastrointestinal Stromal TumorsEpigenetic AlterationsThe majority of gastrointestinal stromal tumors (GISTs) have KIT mutations; however, epigenetic abnormalities that could conceivably potentiate the aggressiveness of GISTs are largely unidentified.21708825
Gastrointestinal Stromal TumorsEpigenetic AlterationsOur aim was to establish epigenetic profiles associated with the malignant transformation of GISTs.21708825
CarcinogenesisEpigenetic AlterationsEpigenetic fingerprint in endometrial carcinogenesis: the hypothesis of a uterine field cancerization.21709441
Malignant NeoplasmsEpigenetic AlterationsNon-endometrioid cancers showed very low levels of epigenetic methylations, but strong P53 protein positivity.21709441
EndometrialEpigenetic AlterationsFinally, this study assessed that the use of an epigenetic fingerprint may improve the current diagnostic tools for a better clinical management of endometrial lesions.21709441
Malignant NeoplasmsEpigenetic AlterationsDNA methylation is an important mechanism of gene silencing in human malignancies.21709715
Psoriasis vulgarisEpigenetic AlterationsmicroRNA-mediated keratinocyte hyperproliferation in psoriasis vulgaris.21711342
Idiopathic Pulmonary FibrosisEpigenetic AlterationsmiRNA and mRNA were isolated from surgical lung biopsies from IPF patients with a clinically documented rapid or slow course of disease over the first year after diagnosis.21712985
Idiopathic Pulmonary FibrosisEpigenetic AlterationsA quantitative PCR miRNA array containing 88 of the most abundant miRNA in the human genome was used to profile lung biopsies from 9 patients with rapidly progressing IPF, 6 patients with slowly progressing IPF, and 10 normal lung biopsies.21712985
Idiopathic Pulmonary FibrosisEpigenetic AlterationsFive miRNA (miR-302c, miR-423-5p, miR-210, miR-376c, and miR-185) were significantly increased in rapid compared with slow IPF lung biopsies.21712985
Idiopathic Pulmonary FibrosisEpigenetic AlterationsThese findings suggest that the development and/or clinical progression of IPF might be the consequence of aberrant miRNA processing.21712985
Idiopathic Pulmonary FibrosisEpigenetic AlterationsA micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis.21712985
NeoplasmsEpigenetic AlterationsA variety of germline and somatic, genetic and epigenetic alterations at 9p21.3, which encode CDKN2A/CDKN2B tumor suppressor genes, have been isolatedly reported to be associated with GBM risk and prognosis.21713760
Ovarian Serous Adenocarcinoma, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours.21720365
ovarian neoplasm, NeoplasmsEpigenetic AlterationsAnalyses delineated four ovarian cancer transcriptional subtypes, three microRNA subtypes, four promoter methylation subtypes and a transcriptional signature associated with survival duration, and shed new light on the impact that tumours with BRCA1/2 (BRCA1 or BRCA2) and CCNE1 aberrations have on survival.21720365
NeoplasmsEpigenetic AlterationsTumor (cellular) and serum microRNA copy numbers from the same 15 patients were correlated.21720996
NeoplasmsEpigenetic AlterationsFurther investigation of potential EBV microRNA target genes revealed inhibition of tumor suppressor genes (eg, PTEN) and extensive deregulation of several pathways frequently involved in NPC (eg, Wnt signaling).21720996
Nasopharyngeal carcinomaEpigenetic AlterationsProfiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs.21720996
Nasopharyngeal carcinoma, NeoplasmsEpigenetic AlterationsEpstein-Barr virus (EBV) microRNAs are abundant in nasopharyngeal carcinoma (NPC) tumors.21720996
NeoplasmsEpigenetic AlterationsTwenty-nine of 39 EBV microRNAs were significantly up-regulated in tumor versus their nontumor biopsies (P < .05).21720996
Non-Small Cell Lung CarcinomaEpigenetic AlterationsPrognostic significance of serum miRNA-21 expression in human non-small cell lung cancer.21721011
NeoplasmsEpigenetic AlterationsDeregulation of microRNAs (miRNAs) plays important roles in tumor progression.21721011
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDysregulated miRNAs in NSCLC serum were identified by microarray.21721011
Secondary malignant neoplasm of liverEpigenetic AlterationsInvasion front-specific expression and prognostic significance of microRNA in colorectal liver metastases.21722265
Cell Invasion, NeoplasmsEpigenetic AlterationsBy comparing samples from the liver invasion front with samples from pure liver parenchyma, the tumor invasion front and the tumor center, 13 miRNA were downregulated.21722265
Secondary malignant neoplasm of liver, NeoplasmsEpigenetic AlterationsIn conclusion, the present study suggests that invasion front-specific downregulation of miRNA in colorectal liver metastases plays a pivotal role in tumor progression.21722265
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia.21724256
Clinical Coordinator, NeoplasmsEpigenetic AlterationsThe results suggested that the epigenetic regulation of SPARC expression in tumor cells versus stromal cells of CRC is significantly different.21725199
Serous Cystadenocarcinoma, Endometrial Endometrioid AdenocarcinomaEpigenetic AlterationsmicroRNA expression profiling of endometrial endometrioid adenocarcinomas and serous adenocarcinomas reveals profiles containing shared, unique and differentiating groups of microRNAs.21725615
Endometrial adenocarcinomaEpigenetic AlterationsQuantitative miRNA profiling of endometrial adenocarcinomas revealed four overlapping groups of significantly overexpressed and underexpressed miRNAs.21725615
Endometrial CarcinomaEpigenetic AlterationsThese validated and potential miRNA target lists were filtered using published lists of genes displaying significant overexpression or underexpression in endometrial cancers compared to benign endometrium.21725615
Malignant NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs) control a multitude of pathways in human cancers.21725615
NeoplasmsEpigenetic AlterationsDifferential expression of miRNAs among different histological types of tumors within the same type of tissue offers insight into the mechanism of pathogenesis and may help to direct treatment to improve prognosis.21725615
Adenocarcinoma, Endometrioid, Adenocarcinoma, Serous CystadenocarcinomaEpigenetic AlterationsThe first group was composed of 20 miRNAs significantly dysregulated in both adenocarcinoma types compared with benign endometrium, two groups were composed of miRNAs significantly dysregulated in either endometrioid adenocarcinomas or in serous adenocarcinomas compared with benign endometrium, and the fourth group was composed of 17 miRNAs that significantly distinguished between endometrioid adenocarcinomas and serous adenocarcinomas themselves.21725615
Endometrioid tumor, NeoplasmsEpigenetic AlterationsValidation of the expression levels of the selected miRNAs was carried out in a second panel composed of ten endometrioid and five serous tumors.21725615
Malignant Neoplasms, Endometrial CarcinomaEpigenetic AlterationsOur results revealed a number of dysregulated miRNAs that are commonly found in endometrial (and other) cancers as well as several dysregulated miRNAs not previously identified in endometrial cancers.21725615
Small cell carcinoma of lungEpigenetic AlterationsMicroRNA expression and clinical outcome of small cell lung cancer.21731696
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsmiR-34a is known as a p53 regulated tumor suppressor microRNA in many cancer types.21731696
Small cell carcinoma of lungEpigenetic AlterationsThe role of microRNAs in small-cell lung carcinoma (SCLC) is largely unknown.21731696
Small cell carcinoma of lungEpigenetic AlterationsThe expression of the 7 microRNAs was unrelated to SCLC patients clinical characteristics and was neither prognostic in term of overall survival or progression-free survival nor predictive of treatment response.21731696
Inflammation, Supranuclear paralysisEpigenetic AlterationsAlthough little is known about the etiology of progressive supranuclear palsy (PSP), genetic and epigenetic factors, oxidative injury and inflammation are thought to contribute to its development and/or progression.21741294
Neoplasms, Malignant neoplasm of gastrointestinal tractEpigenetic AlterationsPrognostic impact of disseminated tumor cells and microRNA-17-92 cluster deregulation in gastrointestinal cancer.21743960
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNA) play key roles in cellular processes implicated in cancer.21743960
NeoplasmsEpigenetic AlterationsmiRNAs were isolated from formalin-fixed, paraffin-embedded tumors.21743960
CarcinogenesisEpigenetic AlterationsSingle nucleotide polymorphisms (SNPs) in miRNAs may contribute to carcinogenesis by altering expression of miRNAs and their targets.21744077
Carcinoma of lungEpigenetic AlterationsA serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer.21744498
Non-Small Cell Lung Carcinoma, ABCB1 wt AlleleEpigenetic AlterationsWe developed a test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of asymptomatic high-risk individuals with 80% accuracy.21744498
NeoplasmsEpigenetic AlterationsThe DNA methylation inhibitor, 5-aza-2-deoxycytidine, activated several of the genes that are demethylated and induced in tumors, supporting a causal role for demethylation in activation of these genes.21747116
Malignant NeoplasmsEpigenetic AlterationsRecently discovered microRNAs (miRNAs), small noncoding RNA molecules, play a crucial role in modulating gene expression networks and are directly involved in the progression of a number of human cancers.21748820
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn this study, we analyzed the expression profile of 858 miRNAs in 38 Estonian nonsmall cell lung cancer (NSCLC) samples (Stage I and II) and 27 adjacent nontumorous tissue samples using Illumina miRNA arrays.21748820
NeoplasmsEpigenetic AlterationsWe found that 39 miRNAs were up-regulated and 33 down-regulated significantly in tumors compared with normal lung tissue.21748820
Liver carcinomaEpigenetic AlterationsCirculating microRNA-21 as a novel biomarker for hepatocellular carcinoma.21749846
Primary malignant neoplasmEpigenetic AlterationsSeveral groups have reported the significance of circulating microRNA as a biochemical marker of cancer.21749846
Liver carcinomaEpigenetic AlterationsTo our knowledge, however, there are no reports on the significance of circulating microRNA in hepatocellular carcinoma.21749846
Liver carcinoma, Hepatitis, ChronicEpigenetic AlterationsPlasma microRNA-21 was also compared in other groups of: 126 patients with hepatocellular carcinoma, 30 patients with chronic hepatitis, and 50 healthy volunteers.21749846
Liver carcinoma, Hepatitis, ChronicEpigenetic AlterationsThe power of microRNA-21 in differentiating hepatocellular carcinoma from chronic hepatitis or from healthy volunteers was compared to that of a-fetoprotein.21749846
Liver carcinoma, Hepatitis, ChronicEpigenetic AlterationsPlasma microRNA-21 level in the 126 patients with hepatocellular carcinoma was significantly higher than in patients with chronic hepatitis and healthy volunteers (p<0.0001, p<0.0001, respectively).21749846
Liver carcinomaEpigenetic AlterationsPlasma microRNA-21 level is a promising biochemical marker for hepatocellular carcinoma.21749846
Leukemia, Myelocytic, AcuteEpigenetic AlterationsFurthermore, we demonstrated for the first time that an aberrant epigenetic pattern involving DNA methylation, H3 and H4 acetylation, and trimethylation of histone H3 lysine 4 and histone H3 lysine 27 might play a role in the transcriptional regulation of EVI1 in acute myeloid leukemia.21750091
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDown-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia.21750091
Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe analyzed the prevalence and prognostic impact of EVI1 over-expression in a series of 476 patients with acute myeloid leukemia, and investigated the epigenetic modifications of the EVI1 locus which could be involved in the transcriptional regulation of this gene.21750091
CarcinogenesisEpigenetic AlterationsWe carried out a global molecular analysis including assessment of ERCC1 expression levels by using both immunohistochemistry (IHC) and quantitative reverse transcriptase PCR (qRT-PCR), genomic instability, global gene and miRNA expression, and sequencing of selected key genes involved in lung carcinogenesis.21750204
NeoplasmsEpigenetic AlterationsThe miRNA expression analysis identified miR-375 as significantly underexpressed in ERCC1-positive tumors.21750204
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, NeoplasmsEpigenetic AlterationsTumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC).21753766
Hypopharyngeal Squamous Cell Carcinoma, Primary malignant neoplasm, Maxillary Sinus Squamous Cell Carcinoma, Squamous cell carcinoma of esophagusEpigenetic AlterationsOur microRNA (miRNA) expression signatures of hypopharyngeal squamous cell carcinoma, maxillary sinus squamous cell carcinoma and esophageal squamous cell carcinoma revealed that miR-375 was significantly reduced in cancer tissues compared with normal epithelium.21753766
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe identification of novel tumor suppressive miRNA and its regulated cancer pathways could provide new insights into potential molecular mechanisms of HNSCC oncogenesis.21753766
Rheumatoid ArthritisEpigenetic AlterationsDNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts.21753787
Breast CarcinomaEpigenetic AlterationsDistinct expressions of microRNAs that directly target estrogen receptor a in human breast cancer.21755340
Breast CarcinomaEpigenetic AlterationsRecently, several microRNAs (miRNAs) that directly target ERa have been identified, and we previously demonstrated that miR-206 expression was downregulated in ERa-positive human breast cancer.21755340
NeoplasmsEpigenetic AlterationsSurprisingly, the expression levels of miR-193b and miR-221 were significantly lower in ERa-negative than in ERa-positive tumors (P = 0.0015 and P = 0.0045, respectively), and the levels of these miRNAs gradually increased as ERa protein expression increased.21755340
Breast CarcinomaEpigenetic AlterationsOur results suggest that miRNAs that directly target ERa have distinct roles in not only regulating ERa but also regulating other target genes in human breast cancer.21755340
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsCopy number changes and DNA methylation alterations are good indicators of carcinogenesis and cancer prognosis.21757291
Ductal Breast Carcinoma, Pancreatic CystEpigenetic AlterationsElevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma.21757972
Pancreatic carcinomaEpigenetic AlterationsDeregulated microRNA (miRNAs) expression is widespread in pancreatic cancer.21757972
Pancreatic CystEpigenetic AlterationsWe assessed whether aberrant miRNAs in pancreatic cyst fluid could be used as potential biomarkers for cystic precursor lesions of pancreatic cancer.21757972
Myeloid Leukemia, ChronicEpigenetic AlterationsAberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia.21760961
Myeloproliferative diseaseEpigenetic AlterationsFive genes were identified by DNA methylation screening in the K562 cell line and 3 genes in patients with myeloproliferative neoplasms.21760961
Myeloid Leukemia, ChronicEpigenetic AlterationsWe conclude that aberrant DNA methylation is associated with CML progression and that DNA methylation could be a marker associated with imatinib resistance.21760961
Myeloid Leukemia, ChronicEpigenetic AlterationsFinally, DNA methylation of PDLIM4 may help identify a subset of CML patients that would benefit from treatment with Src/Abl inhibitors.21760961
Adamantinous CraniopharyngiomaEpigenetic AlterationsCTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas.21761366
Adult CraniopharyngiomaEpigenetic AlterationsOur data suggest the potential involvement of the deregulation of miRNA expression in the craniopharyngioma pathogenesis and outcome and also that the miRNA could modulate the Wnt signaling pathway in craniopharyngioma tumorigenesis.21761366
Adult Craniopharyngioma, Pituitary Gland, AnteriorEpigenetic AlterationsGenes involved in formation/development of the adenohypophysis, CTNNB1 gene, and microRNAs might be implicated in the craniopharyngioma pathogenesis.21761366
22q11.2Epigenetic AlterationsPossible explanations include modification of the effect of TBX1 by genes outside of the 22q11.2 region that may further influence the formation of the palate or heart, or the presence of epigenetic factors that may effect genes within the deleted region, modifying genes elsewhere, or polymorphisms on the normal copy of chromosome 22.21763005
Prostate Cancer PathwayEpigenetic AlterationsDiagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer.21765474
Malignant NeoplasmsEpigenetic AlterationsIt is becoming increasingly evident that small non-coding RNA (ncRNA) species are associated with the development and progression of this malignancy.21765474
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur findings provide miRNA expression signatures that may serve as an accurate tool for the diagnosis and prognosis of PCa.21765474
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsmiRNAs can predict prostate cancer biochemical relapse and are involved in tumor progression.21769427
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsLiterature search shows that many of these miRNAs have an established prognostic significance in other cancers and can be actively involved in tumor progression.21769427
NeoplasmsEpigenetic AlterationsTarget prediction analysis showed that predicted targets of these miRNAs could be involved in biological processes and pathways that enhance tumor progression.21769427
Prostate Cancer PathwayEpigenetic AlterationsmiRNAs can be reliable predictive markers for biochemical relapse of prostate cancer at the time of radical prostatectomy.21769427
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsThe pathogenesis of colorectal carcinoma (CRC) is a complex process that involves the recruitment of both genetic and epigenetic mechanisms.21769619
Cutaneous Melanoma, melanomaEpigenetic AlterationsIn this study, we combined quantitative DNA methylation analysis in patient biopsies and in their derived cell lines to demonstrate that TCF21 expression is downregulated in metastatic melanoma by promoter hypermethylation and TCF21 promoter DNA methylation is correlated with decreased survival in metastatic skin melanoma patients.21771727
Metastasis, melanomaEpigenetic AlterationsEpigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma.21771727
Aggressive behavior, melanomaEpigenetic AlterationsThese data suggest that epigenetic downregulation of TCF21 is functionally involved in melanoma progression and that it may serve as a biomarker for aggressive tumor behavior.21771727
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsHowever, none of the analyzed CpG sites in the three genes showed differences in DNA methylation in islets from donors with T2D compared with non-diabetic donors.21775499
InflammationEpigenetic AlterationsWe hypothesized that body mass may affect DNA methylation through increased estrogen and chronic inflammation.21775555
Postmenopausal stateEpigenetic AlterationsIt may be that the association of body fat composition and postmenopausal breast cancer is related to altered DNA methylation.21775555
Mesothelioma, NeoplasmsEpigenetic AlterationsUsing a case series of MPM patients from the International Mesothelioma Program at the Brigham and Womens hospital, we sought to determine whether epigenetic change at the MSLN gene in patient tumors is responsible for the poor sensitivity of SMRP.21775819
Lichen PlanusEpigenetic AlterationsChanges in miRNA expression in sera and correlation to duration of disease in patients with multifocal mucosal lichen planus.21777290
Lichen PlanusEpigenetic AlterationsEven if no specific LP-associated miRNA profile was found, data clearly indicate that miRNAs could play a role in the earlier phases of lichen planus.21777290
Colorectal Cancer Pathway, AdenomaEpigenetic AlterationsThe presence of cancer-specific DNA methylation patterns in epithelial colorectal cells in human feces provides the prospect of a simple, non-invasive screening test for colorectal cancer and its precursor, the adenoma.21777459
Colorectal Cancer Pathway, AdenomaEpigenetic AlterationsIdentification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas.21777459
Colorectal Carcinoma, AdenomaEpigenetic AlterationsThe novel epigenetic marker panel shows very high sensitivity and specificity for both colorectal cancers and adenomas.21777459
Thyroid Neoplasm, NeoplasmsEpigenetic AlterationsCan the microRNA signature distinguish between thyroid tumors of uncertain malignant potential and other well-differentiated tumors of the thyroid gland?21778212
Follicular thyroid carcinoma, Thyroid Gland Follicular Adenoma, Follicular neoplasm, Papillary thyroid carcinomaEpigenetic AlterationsWe have analyzed the expression of microRNA (miRNA) in a training set of 42 WDT of different histological subtypes: seven follicular tumors of UMP (FT-UMP), six WDT-UMP, seven follicular thyroid adenomas (FTA), 11 conventional papillary thyroid carcinomas (C-PTC), five follicular variants of PTC (FV-PTC), and six follicular thyroid carcinomas (FTC), which led to the identification of about 40 deregulated miRNAs.21778212
Lupus Erythematosus, Systemic, Antiphospholipid SyndromeEpigenetic AlterationsIdentification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome.21794077
Carcinoma, Transitional CellEpigenetic AlterationsCharacterization of microRNAs expression profiling in one group of Chinese urothelial cell carcinoma identified by Solexa sequencing.21795071
Primary malignant neoplasmEpigenetic AlterationsIn addition, transduction of cancer cell lines with DOK1 impaired their proliferation, consistent with the critical role of epigenetic silencing of DOK1 in the development and maintenance of malignant cells.21796618
Primary malignant neoplasmEpigenetic AlterationsThus, hypermethylation of DOK1 is a potentially critical event in human carcinogenesis, and may be a potential cancer biomarker and an attractive target for epigenetic-based therapy.21796618
Uterine Cervical NeoplasmEpigenetic AlterationsDNA methylation markers, with high sensitivity and specificity are urgently needed to improve current population-based screening on (pre)malignant cervical neoplasia.21796628
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) play an important role in carcinogenesis through the regulation of their target genes.21799879
Alzheimers DiseaseEpigenetic AlterationsEpigenetic silencing of nucleolar rRNA genes in Alzheimers disease.21799908
Carcinogenesis, NeoplasmsEpigenetic AlterationsPrevious studies have suggested that SLC5A8 might function as a tumor suppressor gene, whose silencing by epigenetic changes might contribute to carcinogenesis.21802122
Primary central nervous system lymphomaEpigenetic AlterationsUsing paraffin-embedded biopsy specimens from 21 HIV-negative patients with newly diagnosed PCNSL (n = 11) and nDLBCL (n= 10), we measured the expression of 365 miRNA species by quantitative real-time PCR using low-density PCR arrays.21803762
Primary central nervous system lymphomaEpigenetic AlterationsWe conclude that PCNSL exhibits a distinct pattern of miRNA expression compared with nDLBCL.21803762
LymphomaEpigenetic AlterationsDifferential micro-RNA expression in primary CNS and nodal diffuse large B-cell lymphomas.21803762
Primary malignant neoplasmEpigenetic AlterationsMicro-RNAs (miRNAs) have been associated with cancer development and progression.21803762
Primary central nervous system lymphomaEpigenetic AlterationsWe found that 18 miRNAs were differentially expressed: median expression levels of 13 miRNAs were 2.1-13.1 times higher in PCNSL, and median expression levels of 5 miRNAs were 2.6-3.3 times higher in nDLBCL.21803762
MIR20A gene, Primary central nervous system lymphomaEpigenetic AlterationsMiRNAs upregulated in PCNSL were associated with the Myc pathway (miR-17-5p, miR-20a, miR-9), with blocking of terminal B-cell differentiation (miR-9, miR-30b/c), or with upregulation by inflammatory cytokines (miR-155).21803762
Primary central nervous system lymphomaEpigenetic AlterationsPutative tumor-suppressor miRNAs (miR-199a, miR-214, miR-193b, miR-145) were downregulated in PCNSL.21803762
Primary central nervous system lymphomaEpigenetic AlterationsThere was no overlap of miRNAs dysregulated in PCNSL with those differentially expressed between immunohistologically defined germinal center B cell-like (GCB) and non-GCB types or, apart from miR-9, with miRNAs known to be overexpressed in human brain.21803762
Cardiovascular DiseasesEpigenetic AlterationsMicroRNAs (miRNAs) are a novel class of small, non-coding RNAs that play a significant role in both inflammatory and cardiovascular diseases.21804579
Primary malignant neoplasmEpigenetic AlterationsThe phosphatidylinositol-3-OH kinase (PI3K)-Akt pathway is activated in cancer by genetic or epigenetic events and efforts are under way to develop targeted therapies.21804599
ovarian neoplasmEpigenetic AlterationsThis chapter will provide in-depth protocols to analyze epigenetic alterations in proprotein convertase gene expression using the PCSK6 gene in the context of human ovarian cancer as a model system.21805246
Malignant NeoplasmsEpigenetic AlterationsIt has been suggested that the presence of single nucleotide polymorphisms in precursor miRNAs (pre-miRNAs) can alter miRNA processing, expression, and/or binding to target mRNA and represent another type of genetic variability that can contribute to the susceptibility of human cancers.21807077
Primary malignant neoplasmEpigenetic AlterationsAberrant expression and structural alteration of miRNAs are considered to participate in tumorigenesis and cancer development.21807077
Malignant Neoplasms, Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsTo characterize the interactions of non-small cell lung cancer (NSCLC) tumors with the immune system at the level of mRNA and microRNA (miRNA) expression and to define expression signatures that characterize the presence of a malignant tumor versus a nonmalignant nodule.21807633
NeoplasmsEpigenetic AlterationsA tumor presence in the lung influences mRNA and miRNA expression in PBMC and this influence is reversed by tumor removal.21807633
NeoplasmsEpigenetic AlterationsAdditional important regulators included five miRNAs expressed at significantly higher levels before tumor removal.21807633
Loss, Supranuclear paralysisEpigenetic AlterationsMicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy.21807765
TauopathiesEpigenetic AlterationsTaken together, these results suggest that changes in the miR-132/PTBP2 pathway could contribute to the abnormal splicing of tau exon 10 in the brain, and sheds light into the potential role played by miRNAs in a subset of tauopathies.21807765
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTesticular germ cell tumors (TGCTs) have a unique epigenetic profile distinct from that of other types of cancer.21809391
Acute lymphocytic leukemiaEpigenetic AlterationsSeveral miRNAs have been found to be inappropriately regulated by DNA methylation in patients with acute lymphoblastic leukaemia (ALL).21810092
Acute lymphocytic leukemiaEpigenetic AlterationsDeregulation of FGFR1 and CDK6 oncogenic pathways in acute lymphoblastic leukaemia harbouring epigenetic modifications of the MIR9 family.21810092
NeoplasmsEpigenetic AlterationsThe role of epigenetic mechanisms in the regulation of microRNAs (miRNAs) with a tumour-suppressor function in human neoplasms has recently been established.21810092
Acute lymphocytic leukemiaEpigenetic AlterationsEpigenetic downregulation of MIR9 induced upregulation of its targets, FGFR1 and CDK6, while treatment of ALL cells with FGFR1 (PD-173074) and CDK6 (PD-0332991) inhibitors induced a decrease in cell proliferation and an increase in apoptosis of ALL cells.21810092
Acute lymphocytic leukemiaEpigenetic AlterationsOur results indicate that the MIR9 family is involved in the pathogenesis and clinical behaviour of ALL and provide the basis for new therapeutic strategies in the treatment of ALL, targeting the epigenetic regulation of miRNAs and/or the FGFR1 or CDK6-RB pathway directly.21810092
Prostate Cancer PathwayEpigenetic AlterationsNMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene.21810217
Tongue DiseasesEpigenetic AlterationsOn an individual gene level, significant enrichment of transcripts early in dengue disease were chemokines CCL2 (MCP-1), CCL8 (MCP-2), CXCL10 (IP-10) and CCL3 (MIP-1a), antimicrobial peptide b-defensin 1 (DEFB1), desmosome/intermediate junction component plakoglobin (JUP) and a microRNA which may negatively regulate pro-inflammatory cytokines in dengue infected peripheral blood cells, mIR-147 (NMES1).21810247
ovarian neoplasmEpigenetic AlterationsEvidence for the complexity of microRNA-mediated regulation in ovarian cancer: a systems approach.21811625
Primary malignant neoplasmEpigenetic AlterationsOur findings underscore the complexities of miRNA-mediated regulation in vivo and the necessity of understanding the basis of these complexities in cancer cells before the therapeutic potential of miRNAs can be fully realized.21811625
Disease, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases including cancer.21811625
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsHowever, the potential clinical utility of miRNAs in cancer therapy rests heavily upon our ability to understand and accurately predict the consequences of fluctuations in levels of miRNAs within the context of complex tumor cells.21811625
Plaque (lesion)Epigenetic AlterationsA unique microRNA signature associated with plaque instability in humans.21817153
Medical Device Material Rupture, Plaque, Atherosclerotic, atheroscleroticEpigenetic AlterationsThese results are the first to report alterations in the expression of specific miRNAs in human atherosclerotic plaques and suggest that miRNAs may have an important role in regulating the evolution of atherosclerotic plaque toward instability and rupture.21817153
Primary malignant neoplasmEpigenetic AlterationsThe choice of specific regions in the CpG island is a critical step in determining the functional role and prognostic value of DNA methylation in cancer cells.21818286
Adenocarcinoma Of EsophagusEpigenetic AlterationsLocation-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas.21818286
Squamous cell carcinoma, SERPINB3 wt Allele, Molecular AbnormalityEpigenetic AlterationsRecent studies indicate various molecular abnormalities in oral squamous cell carcinomas (OSCC), including DNA methylation of tumor-associated genes.21819494
Colorectal Cancer Pathway, Colorectal NeoplasmsEpigenetic AlterationsOverall, this study identifies for the first time the relevant metallothionein isoforms for colorectal cancer progression, supports the concept that their loss is associated with worse prognosis, and suggests 2 mechanisms for epigenetic repression of metallothionein expression in colorectal tumors.21820154
atheroscleroticEpigenetic AlterationsThe microRNA expression profile differs significantly between atherosclerotic plaques and control arteries.21820659
Plaque, Atherosclerotic, Cardiovascular DiseasesEpigenetic AlterationsInterfering with the miRNA expression in the artery wall is a potential way to affect atherosclerotic plaque and cardiovascular disease development.21820659
atheroscleroticEpigenetic AlterationsTen miRNAs were found to be differently expressed in atherosclerotic plaques when compared to controls (p<0.05).21820659
ArteriosclerosisEpigenetic AlterationsThe most up-regulated miRNAs are involved in processes known to be connected to atherosclerosis.21820659
Primary malignant neoplasmEpigenetic AlterationsEpigenetic control of CDK2NA was observed in vitro in 11 cancer cell lines.21821326
Thrombocytosis, Polycythemia VeraEpigenetic AlterationsEpigenomic profiling in polycythaemia vera and essential thrombocythaemia shows low levels of aberrant DNA methylation.21821860
Carcinogenesis, NeoplasmsEpigenetic AlterationsAberrant DNA methylation in promoters of tumor suppressor genes is an early and frequent event during prostate carcinogenesis.21822036
CHOANAL ATRESIA, POSTERIOR, Primary malignant neoplasmEpigenetic AlterationsModern techniques allow a sensitive detection of DNA methylation biomarkers in bodily fluids from cancer patients offering a noninvasive tool for PCa monitoring.21822036
Malignant tumor of colonEpigenetic AlterationsThere is significant difference of miRNA expression between colon caner and normal colonic mucosa.21826996
Malignant tumor of colon, MicroRNA 105Epigenetic AlterationsThe up-regulated miRNAs in colon cancer included has-miR-182, has-miR-17, hasmiR-106a, has-miR-93, has-miR-200c, has-miR-92a, has-let-7a, has-miR-20a (FDR value < 5%), while the downregulated miRNAs were has-miR-l195, has-miR-143, has-miR-145 (FDR value < 5%).21826996
Secondary malignant neoplasm of liverEpigenetic AlterationsRT-PCR and qPCR were used to detect miRNA expression in liver metastases by utilizing TaqMan(r) MicroRNA Reverse Transcription Kit and TaqMan(r) miRNA Assays.21827717
Colorectal Cancer Pathway, DICER1 protein, humanEpigenetic AlterationsDicer and miRNA in relation to clinicopathological variables in colorectal cancer patients.21827717
Secondary malignant neoplasm of liverEpigenetic AlterationsWe also correlated the expression of Dicer mRNA to the miRNA expression of miR-141, miR-200a, miR-200b, mir-200c and miR-429 in liver metastases.21827717
Leukemia, Myelomonocytic, ChronicEpigenetic AlterationsMutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.21828135
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma.21829728
GliomaEpigenetic AlterationsAs a global DNA methylation marker, LINE-1 may be a promising marker in gliomas.21829728
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsDNA methylation changes correlate with Gleason score and tumor stage in prostate cancer.21830905
NeoplasmsEpigenetic AlterationsDNA methylation, a widely used epigenetic mark, has been associated with many tumors.21830905
Aggressive behavior, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsHowever, few studies have addressed the role of cell-free plasma DNA methylation in discriminating aggressive prostate cancer (PCa) from indolent cases.21830905
NeoplasmsEpigenetic AlterationsDNA methylation levels were significantly higher in tumor tissue than in adjacent nontumor tissue for p16 (CDKN4A), GSTP1, and APC; GSTP1 had a higher average percentage methylation in tumor tissue (38.9%) compared with p16 (CDKN4A) (5.9%) and APC (14.5%).21830905
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).21831520
Malignant Neoplasms, Stomach CarcinomaEpigenetic AlterationsEpigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown.21831520
Islet Cell TumorEpigenetic AlterationsRASSF1A gene silencing by DNA methylation has been suggested as a major event in pancreatic endocrine tumor (PET) but RASSF1A expression has never been studied.21838870
Squamous cell carcinoma of esophagusEpigenetic AlterationsOur results suggest that aberrant histone modifications may play an important role in the development and progression of ESCC.21843048
Squamous cell carcinoma of esophagusEpigenetic AlterationsAbnormal histone acetylation and methylation levels in esophageal squamous cell carcinomas.21843048
Malignant NeoplasmsEpigenetic AlterationsWe aimed to identify novel DNA methylation biomarkers common to these three urological cancers, potentially suitable for non-invasive testing.21847011
Maxillary Sinus Squamous Cell Carcinoma, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma.21847129
Maxillary Sinus Squamous Cell Carcinoma, Primary malignant neoplasmEpigenetic AlterationsOn the basis of the microRNA (miRNA) expression signature of maxillary sinus squamous cell carcinoma (MSSCC), we found that miR-874 was significantly reduced in cancer cells.21847129
NeoplasmsEpigenetic AlterationsThe downregulation of miR-874 was a frequent event in MSSCC, which suggests that miR-874 functions as a tumour suppressive miRNA, directly regulating PPP1CA that has a potential role of an oncogene.21847129
Clinical Coordinator, NeoplasmsEpigenetic AlterationsMoreover, we have shown CpG island-associated promoter of MLL3 gene has no DNA methylation in CRC cells but also primary tumor and normal colon, and this region has a highly homologous of pseudo gene (psiTPTE22) that was age relate DNA methylation.21853109
ovarian neoplasm, NeoplasmsEpigenetic AlterationsIn attempt to discover novel aberrantly hypermethylated genes with putative tumor suppressor function in epithelial ovarian cancer (EOC), we applied expression profiling following pharmacologic inhibition of DNA methylation in EOC cell lines.21856257
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe role of p16 is gaining importance in non-small cell lung cancer (NSCLC) because of epigenetic therapy options.21857254
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsThe DNA methylation inhibitor 5-aza-2-deoxycytidine (DAC) is approved for the treatment of myelodysplastic syndromes (MDS), but resistance to DAC develops during treatment and mechanisms of resistance remain unknown.21858090
malignant disease, CholedocholithiasisEpigenetic AlterationsUsing high-throughput real-time PCR-based miRNA microarrays, the expression profiles of 667 miRNAs were compared in patients with malignant disease (n = 9) and age-matched patients with the benign disease choledocholithiasis (n = 9).21858175
Primary malignant neoplasmEpigenetic AlterationsIn recent years, it has been suggested that profiles for circulating miRNAs, as well as those for tissue miRNAs, have the potential to be used as diagnostic biomarkers for cancer.21858175
Hepatobiliary DisorderEpigenetic AlterationsThese findings suggest that bile miRNAs could be informative biomarkers for hepatobiliary disease and that some miRNAs, particularly miR-9, may be helpful in the diagnosis and clinical management of BTC.21858175
Adrenocortical carcinomaEpigenetic AlterationsThe role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma.21859927
Agenesis of corpus callosum, AdenomaEpigenetic AlterationsmiRNA expression profiles were determined in a series of ACC, adenoma, and normal cortices using microarray.21859927
AdenomaEpigenetic AlterationsA subset of miRNAs showed distinct expression patterns in the ACC compared with adrenal cortices and adenomas.21859927
Agenesis of corpus callosum, Tumors of Adrenal CortexEpigenetic AlterationsIn summary, we identified additional miRNAs associated with ACC, elucidated the functional role of four miRNAs in the pathogenesis of ACC cells, demonstrated the potential involvement of the pro-apoptotic factor PUMA (a miR-483-3p target) in adrenocortical tumors, and found novel miRNAs associated with survival in ACC.21859927
Colorectal CarcinomaEpigenetic AlterationsLong noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers.21862635
Secondary malignant neoplasm of female breastEpigenetic AlterationsIn cooperation with Polycomb complex PRC2, the HOTAIR long ncRNA is reported to reprogram chromatin organization and promote breast cancer metastasis.21862635
Clinical Coordinator, Breast CarcinomaEpigenetic AlterationsOur findings suggest that HOTAIR expression is associated with a genome-wide reprogramming of PRC2 function not only in breast cancer but also in CRC, where upregulation of this long ncRNA may be a critical element in metastatic progression.21862635
Primary malignant neoplasmEpigenetic AlterationsThe functional impact of recently discovered long noncoding RNAs (ncRNAs) in human cancer remains to be clarified.21862635
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNAs (miRNA) are tiny, noncoding, small, endogenous RNAs that play major roles in neoplastic transformation and could therefore offer a better quantitative and noninvasive method for the diagnosis and prognosis of colorectal cancer (CRC) using feces.21863218
Clinical CoordinatorEpigenetic AlterationsWe demonstrated that miRNAs are stable in the fecal microenvironment, and that, among them, miR-144* represents a novel fecal-based diagnostic marker for CRC screening.21863218
Carcinoma of lungEpigenetic AlterationsDiagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers.21864403
Peripheral Nerve Neoplasms, MalignantEpigenetic AlterationsWe then validate the miRNA panel in a testing set of 76 patients with malignant SPNs and 80 patients with benign SPNs.21864403
Carcinoma of lungEpigenetic AlterationsWe previously demonstrated that microRNAs (miRNAs) could be used as biomarkers for lung cancer diagnosis.21864403
Lung NeoplasmsEpigenetic AlterationsThe three miRNAs used in combination produced the area under receiver operating characteristic curve at 0.86 in distinguishing lung tumors from benign SPNs with 75.00% sensitivity and 84.95% specificity.21864403
Carcinoma of lungEpigenetic AlterationsThe plasma miRNAs provide potential circulating biomarkers for noninvasively diagnosing lung cancer among individuals with SPNs, and could be further evaluated in clinical trials.21864403
NeoplasmsEpigenetic AlterationsThe growth suppression by miRNAs in PDFS cells is consistent with the hypothesis that the DLK1-MEG3 locus plays a tumor suppressor role in human NFAs.21871428
SERPINB3 wt Allele, NeoplasmsEpigenetic AlterationsA significant association was revealed between some clinicopathological findings and the DNA methylation status of WNT7A (normal vs tumor, P=0.007; T1-2 vs T3-4, P=0.040; I-III vs IV, P=0.016) and WNT10A (N0-N1 vs N2-N3, P=0.046) in the advanced stages of OSCC.21874048
Primary malignant neoplasmEpigenetic AlterationsmiRNA expression profiles may become useful biomarkers for diagnostics, prognosis and prediction of response to treat, and it could be a powerful tool for cancer prevention and therapeutics.21874264
Stomach CarcinomaEpigenetic AlterationsSeveral miRNA expression profiles of miRNAs in gastric cancer have been reported, but these studies screened only few miRNAs and samples used in experiments include several different subtypes of gastric cancers, which decrease the sensitivity to identify new aberrant miRNAs.21874264
Malignant neoplasm of stomachEpigenetic AlterationsForty miRNA precursors were up-regulated and thirty-six miRNA were down-regulated in intestinal-type gastric cancers (p<0.01).21874264
Stomach CarcinomaEpigenetic AlterationsIdentification of new aberrantly expressed miRNAs in intestinal-type gastric cancer and its clinical significance.21874264
Malignant neoplasm of stomachEpigenetic AlterationsSixteen new miRNAs were found in intestinal-type gastric cancers.21874264
Malignant neoplasm of stomachEpigenetic AlterationsSeventeen new miRNAs were found in intestinal-type gastric cancers.21874264
Malignant neoplasm of stomachEpigenetic AlterationsTaken together, aberrantly expressed miRNAs may offer new clues to tumorigenesis of gastric cancers.21874264
CarcinogenesisEpigenetic AlterationsChange in MTHFR activity may influence both DNA methylation and synthesis, crucial steps in carcinogenesis.21875294
Liver carcinomaEpigenetic AlterationsMicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma.21878637
Hollings Cancer CenterEpigenetic AlterationsCompelling evidence has suggested the important roles of microRNAs in HCC development.21878637
Prostate Cancer Pathway, Metastasis, Prostatic Intraepithelial NeoplasiasEpigenetic AlterationsMicroRNA expression profiles in the progression of prostate cancer--from high-grade prostate intraepithelial neoplasia to metastasis.21880514
MetastasisEpigenetic AlterationsInterestingly, there was a significant global loss of miRNA expression between HGPIN and metastasis at 2 important steps.21880514
CarcinogenesisEpigenetic AlterationsThe importance of our study is in the identification of possible miRNAs and miRNA-targeted genes involved in the progression of prostate carcinogenesis that may help the development of potential diagnostic or prognostic markers as well as the design of new target therapies.21880514
Acute myocardial infarctionEpigenetic AlterationsCirculating microRNAs are promising novel biomarkers of acute myocardial infarction.21881276
Malignant NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs), small non-coding RNAs, are always aberrantly expressed in many diseases including human cancers.21882196
Squamous cell carcinoma of esophagusEpigenetic AlterationsVarious statistical methods were used to analyze the relationship between miRNA expression and clinicopathologic features and prognosis in 91 patients with ESCC.21882196
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsGrowing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis.21883694
Squamous cell carcinoma of lungEpigenetic AlterationsA 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis.21890451
Carcinoma of lungEpigenetic AlterationsRecent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but microRNA signatures varied between different populations.21890451
Chronic Lymphocytic LeukemiaEpigenetic AlterationsFurthermore, we measured the expression of the 13q14-resident microRNAs by quantitative PCR (Q-PCR) in 242 CLL patients and subsequently assessed their prognostic significance.21890456
Chronic Kidney DiseasesEpigenetic AlterationsCirculating microRNA expression is reduced in chronic kidney disease.21891774
Kidney Failure, ChronicEpigenetic AlterationsWe measured the levels of miRNAs in patients with different stages of chronic kidney failure including those receiving maintenance haemodialysis treatment.21891774
Chronic Kidney Diseases, Renal InsufficiencyEpigenetic AlterationsIn patients with severe chronic renal failure, circulating levels of total and specific miRNAs are reduced in comparison to patients with mild renal impairment or normal renal function.21891774
Chronic Kidney Diseases, Hyperparathyroidism, AnemiaEpigenetic AlterationsA strong correlation exists between detected circulating miRNAs and estimated glomerular filtration rate, and less strong correlations with other features of chronic kidney disease, such as anaemia and hyperparathyroidism.21891774
Endometrial CarcinomaEpigenetic AlterationsThe microRNA-200 family is upregulated in endometrial carcinoma.21897839
Chronic active hepatitisEpigenetic AlterationsWe compared the expression profiles of 723 human miRNAs from 14 cases of EEC, 10 cases of CAH, and 10 normal proliferative endometria controls using Agilent Human miRNA arrays following RNA extraction from formalin-fixed paraffin-embedded (FFPE) tissues.21897839
Chronic active hepatitisEpigenetic AlterationsThis information contributes to the candidate miRNA expression profile that has been generated for EEC and shows that certain miRNAs are dysregulated in the precursor lesion, CAH.21897839
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs are dysregulated in cancer and may play essential roles in tumorigenesis.21897839
Primary malignant neoplasmEpigenetic AlterationsAdditionally, miRNAs have been shown to have prognostic and diagnostic value in certain types of cancer.21897839
Chronic active hepatitisEpigenetic AlterationsForty-three miRNAs were dysregulated in EEC and CAH compared to normal controls (p<0.05).21897839
Breast Carcinoma, Breast Cancer CellEpigenetic AlterationsLarge-scale profiling approaches have revealed global down-regulation of microRNAs (miRNAs) in several human cancer types including breast cancer.21898071
Breast CarcinomaEpigenetic AlterationsIn conclusion, the decreased expression of Dicer and Drosha may play a role in down-regulation of miRNAs in breast cancer.21898071
Primary Biliary CholangitisEpigenetic AlterationsWe hypothesized that CD40L may play a key role in the pathogenesis of the elevated serum IgM and analyzed genetic and epigenetic modifications of the gene coding for CD40L in CD4(+) and CD8(+) T cells isolated from circulating mononuclear cells from PBC patients and healthy controls.21898485
Leukemia, Myelocytic, AcuteEpigenetic AlterationsCancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia.21898529
NeoplasmsEpigenetic AlterationsEpigenetic therapy to reactivate tumor suppressor genes may enhance the anti-proliferative effect of erlotinib.21901396
Carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsWe searched the published literature for the miRNA microarray data of primary lung cancer and selected 15 miRNAs that were most frequently up-regulated in lung cancer tissues.21904633
Carcinoma of lungEpigenetic AlterationsPlasma microRNAs as novel biomarkers for early detection of lung cancer.21904633
Carcinoma of lungEpigenetic AlterationsMicroRNAs (miRNAs), a family of 19- to 25-nucleotide non-coding small RNAs, are frequently dysregulated in lung cancer.21904633
Carcinoma of lungEpigenetic AlterationsThe levels of miRNAs were determined by real-time RT-PCR in 74 lung cancer patients and 68 age-matched cancer-free controls.21904633
Carcinoma of lungEpigenetic AlterationsThe combination of these 3 miRNAs yielded 81.33% sensitivity and 86.76% specificity in discriminating lung cancer patients from controls.21904633
Chronic Lymphocytic LeukemiaEpigenetic AlterationsTaking this into account, we evaluated if genetic and/or epigenetic variation in the ATM gene may modulate the individual susceptibility to develop CLL.21910157
Prostate carcinomaEpigenetic AlterationsPromoter hypermethylation is an important epigenetic mechanism in the regulation of several key modulators of prostate carcinoma progression.21912429
Pancreatic carcinomaEpigenetic AlterationsCombination of plasma microRNAs with serum CA19-9 for early detection of pancreatic cancer.21913185
Primary malignant neoplasmEpigenetic AlterationsSerum microRNAs have the potential to be valuable biomarkers of cancer.21914171
Malignant Neoplasms, CarcinogenesisEpigenetic AlterationsNADPH oxidase DUOX1, DUOX2, and NOX4 have recently been gained considerable concerns, owing to the fact that they involve in reactive oxygen species-induced genetic and epigenetic alternations of human carcinogenesis and serve as biomarkers in several cancers.21915726
CarcinogenesisEpigenetic AlterationsAberrant DNA methylation plays a critical role in carcinogenesis, and the availability of dietary factors involved in 1-carbon metabolism may contribute to aberrant DNA methylation.21916701
Malignant Neoplasms, Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsMicro RNAs are often aberrantly expressed in cancer and microRNA-21 is upregulated in a variety of cancers, including breast cancer.21917003
NeoplasmsEpigenetic AlterationsOur result enlightens the accumulation of aberrant DNA methylation which occurs in concordance with the tumor progression.21917081
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsCpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer.21917081
Ischemia, Primary malignant neoplasmEpigenetic AlterationsIschemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue.21917534
Primary malignant neoplasmEpigenetic AlterationsSeveral of the 56 miRNAs have been reported to play a role in cancer, such as hsa-miR-663 and hsa-miR-125a-3p.21917534
IschemiaEpigenetic AlterationsCaution should be taken when the miRNAs and mRNAs reported to be affected by ischemia time are included in a prognostic or predictive signature.21917534
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAberrant DNA methylation and concomitant transcriptional silencing of death-associated protein kinase 1 (DAPK1) have been demonstrated to be key pathogenic events in chronic lymphocytic leukemia (CLL).21918973
SF3B1 wt Allele, Leukemia, Myelocytic, Acute, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsIn acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), however, the presence of elevated DNA methylation levels has been a matter of continued controversy.21918973
Maxillary Sinus Squamous Cell Carcinoma, NeoplasmsEpigenetic AlterationsTumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma.21922130
Primary malignant neoplasm, Maxillary Sinus Squamous Cell CarcinomaEpigenetic AlterationsThe expression of microRNA-375 (miR-375) is significantly reduced in cancer tissues of maxillary sinus squamous cell carcinoma (MSSCC).21922130
Clinical CoordinatorEpigenetic AlterationsWe found 75 candidate genes that were potentially suppressed by DNA methylation in CRC.21922135
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA profiling differentiates colorectal cancer according to KRAS status.21922590
NeoplasmsEpigenetic AlterationsRecent studies have shown the important role of microRNAs (miRNAs) in a variety of biological processes, and in its ability to distinguish tumors according to their prognostic and predictive properties.21922590
NeoplasmsEpigenetic AlterationsComparing these with normal colon tissue, we identified 49 miRNAs--including 19 novel miRNAs--significantly deregulated in tumor tissue.21922590
NeoplasmsEpigenetic AlterationsPolycomb group genes (PcGs) are epigenetic modifiers involved in tumor suppressor gene silencing.21926398
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations also affect the expression of cancer genes, either alone or in combination with genetic mechanisms.21928112
Malignant NeoplasmsEpigenetic AlterationsThe current evidence suggests that hypermethylation of promoter CpG islands is a common epigenetic event in a variety of human cancers.21928112
FHIT protein, humanEpigenetic AlterationsFurthermore, inactivation of FHIT by epigenetic mechanisms in GBM may not be associated with brain tumorigenesis.21928112
Clinical CoordinatorEpigenetic AlterationsMiRNA levels in CRC tissues and stool samples were detected by real-time quantitative reverse transcription PCR.21930727
Clinical Coordinator, polypsEpigenetic AlterationsStool miRNA are useful for screening CRC and polyps.21930727
Pancreatic Intraductal Papillary Mucinous NeoplasmEpigenetic AlterationsCarcinogenesis of intraductal papillary mucinous neoplasm of the pancreas: loss of microRNA-101 promotes overexpression of histone methyltransferase EZH2.21932133
Hollings Cancer CenterEpigenetic AlterationsUp-regulation of ABC transporters in HCC occurs prior to chemotherapeutic treatment and is associated with miRNA down-regulation.21932399
Liver carcinomaEpigenetic AlterationsAdenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs.21932399
Hollings Cancer CenterEpigenetic AlterationsBecause cellular microRNAs (miRNAs) are involved in posttranscriptional gene silencing, we hypothesized that regulation of ABC expression in HCC might be mediated by miRNAs.21932399
Hollings Cancer CenterEpigenetic AlterationsUp-regulation of five ABC genes appears to be mediated by 13 cellular miRNAs in HCC patient samples.21932399
Colorectal Cancer Pathway, Neoplasm MetastasisEpigenetic AlterationsMicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4.21934092
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) regulate tumor progression and invasion via direct interaction with target messenger RNAs (mRNAs).21934092
DICER1 protein, humanEpigenetic AlterationsDicer, a ribonuclease III-like enzyme is essential for miRNA processing.21937200
TSPYL2 wt AlleleEpigenetic AlterationsOur data suggest Dicer expression as a possible molecular marker in patients with MF and apparently indicate that miRNA(s) might be of clinical relevance in CTCL.21937200
Lymphoma, T-Cell, Cutaneous, NeoplasmsEpigenetic AlterationsAberrant expression of microRNAs (miRNAs) has been implicated in oncogenesis of various tumors and primary cutaneous T cell lymphomas.21937200
Carcinogenesis, Glioblastoma Multiforme PathwayEpigenetic AlterationsBecause of the involvement of miRNA in carcinogenesis, miRNAs in CSF may serve as unique biomarkers for minimally invasive diagnosis of glioma.21937590
Glioblastoma Multiforme PathwayEpigenetic AlterationsIdentification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma.21937590
GliomaEpigenetic AlterationsAccordingly, miRNAs in the CSF have the potential to serve as novel biomarkers for the detection of gliomas.21937590
nucleolinEpigenetic AlterationsNucleolin seems to be over-expressed in highly proliferative cells and is involved in many aspect of gene expression: DNA recombination and replication, RNA transcription by RNA polymerase I and II, rRNA processing, mRNA stabilization, cytokinesis, and apoptosis.21938743
Chronic Obstructive Airway DiseaseEpigenetic AlterationsGene expression networks in COPD: microRNA and mRNA regulation.21940491
Chronic Obstructive Airway DiseaseEpigenetic AlterationsmiRNA and mRNA expression were compared to enrich for biological networks relevant to the pathogenesis of COPD.21940491
Lung Diseases, Obstructive, Chronic Obstructive Airway DiseaseEpigenetic AlterationsLung tissue from smokers with no evidence of obstructive lung disease (n=9) and smokers with COPD (n=26) was examined for miRNA and mRNA expression followed by validation.21940491
Chronic Obstructive Airway DiseaseEpigenetic AlterationsmiRNA and mRNA expression profiles enriched for biological pathways that may be relevant to the pathogenesis of COPD including the transforming growth factor b, Wnt and focal adhesion pathways.21940491
Chronic Obstructive Airway DiseaseEpigenetic AlterationsmiRNA and mRNA are differentially expressed in individuals with COPD compared with smokers without obstruction.21940491
Chronic Obstructive Airway DiseaseEpigenetic AlterationsIdentifying expression patterns of miRNAs in COPD may enhance our understanding of the mechanisms of disease.21940491
Chronic Obstructive Airway DiseaseEpigenetic Alterations70 miRNAs and 2667 mRNAs were differentially expressed between lung tissue from subjects with COPD and smokers without COPD.21940491
Chronic Obstructive Airway DiseaseEpigenetic AlterationsmiR-223 and miR-1274a were the most affected miRNAs in subjects with COPD compared with smokers without obstruction.21940491
DiseaseEpigenetic AlterationsMicroRNAs are small non-coding RNAs involved in normal processes such as development and differentiation as well as progression of human diseases.21943223
Lichen PlanusEpigenetic AlterationsAltered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus.21943223
Prostate Cancer PathwayEpigenetic AlterationsThe investigational ProCaM(tm) prostate cancer methylation assay detects aberrant methylation of DNA in cells associated with prostate cancer.21944123
Prostate Cancer PathwayEpigenetic AlterationsThe assay is designed to detect epigenetic modifications in the 3 markers GSTP1, RARb2 and APC, which are indicative of prostate cancer.21944123
Stomach CarcinomaEpigenetic AlterationsThis study underscores the potential application of measurement of serum DNA methylation of these genes, as promising tool for gastric cancer detection.21945024
Antigen-Presenting Cells, Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic Alterations[Expression of DNA methylation of APC in peripheral blood and tumor tissue in patients with esophageal squamous cell carcinoma].21948542
Upper Gingival Squamous Cell CarcinomaEpigenetic AlterationsRevisit of field cancerization in squamous cell carcinoma of upper aerodigestive tract: better risk assessment with epigenetic markers.21952583
Malignant NeoplasmsEpigenetic AlterationsTraditional risk factors allowed us to discriminate between patients with and without cancers with 74% sensitivity (95% CI: 67%-81%), 74% specificity (66%-82%), and 80% area under the curve (67%-91%); epigenetic markers in normal esophageal mucosa had values of 74% (69%-79%), 75% (67%-83%), and 83% (79%-87%); and both together had values of 82% (76%-88%), 81% (74%-88%), and 91% (88%-94%).21952583
Hematologic NeoplasmsEpigenetic AlterationsHomeobox (HOX) gene transcription factors are frequently deregulated in hematologic malignancies and involved in leukemogenic transformation [1].21953534
Lynch SyndromeEpigenetic AlterationsConstitutional epimutations of DNA mismatch repair (MMR) genes have been recently reported as a possible cause of Lynch syndrome.21953887
Lynch SyndromeEpigenetic AlterationsA cohort of 134 unrelated Lynch syndrome-suspected patients without MMR germline mutation was screened for constitutional epimutations of MLH1 and MSH2 by quantitative bisulfite pyrosequencing.21953887
NeoplasmsEpigenetic AlterationsTumors from patients with constitutional epimutations were extensively analyzed.21953887
Colonic Neoplasms, Primary malignant neoplasmEpigenetic AlterationsFor one of them, we report for the first time evidence of transmission to two children who also developed early colonic tumors, indicating that constitutional MLH1 epimutations are associated to a real risk of transgenerational inheritance of cancer susceptibility.21953887
Primary malignant neoplasmEpigenetic AlterationsEvidence of constitutional MLH1 epimutation associated to transgenerational inheritance of cancer susceptibility.21953887
BRAF gene, NeoplasmsEpigenetic AlterationsMoreover, a somatic BRAF mutation was detected in one affected child, indicating that tumors from patients carrying constitutional MLH1 epimutation can mimic MSI-high sporadic tumors.21953887
Plaque, AtheroscleroticEpigenetic AlterationsSomatic mutation theory of atherogenesis proved by alterations at the DNA level such as "loss of heterozygosity" and microsatellite instability in atherosclerotic plaque is complemented by the date of epigenetic variability of genetic loci involved in the pathological process.21954592
Malignant neoplasm of thyroidEpigenetic AlterationsStandardized incidence rates for thyroid cancer were 72 [95% confidence interval (CI), 51-99; P < 0.001] for pathogenic PTEN mutations, 63 (95% CI, 42-92; P < 0.001) for SDHx variants, and 45 (95% CI, 26-73; P < 0.001) for KLLN epimutations.21956414
Leukemia, Myelocytic, AcuteEpigenetic AlterationsPrognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks.21960591
Primary malignant neoplasm, Leukemia, Myelocytic, AcuteEpigenetic AlterationsAberrant DNA methylation is a hallmark of cancer, including AML.21960591
Clinical CoordinatorEpigenetic AlterationsHere we used TaqMan Array MicroRNA Cards, capable of detecting 664 unique human microRNAs (miRNAs), to describe changes of the miRNA transcriptome following disruption of beta-catenin/TCF4 activity in DLD1 CRC cells.21963845
Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsAttenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes.21963845
Clinical CoordinatorEpigenetic AlterationsSeveral of these miRNAs (miR-145, miR-126, miR-30e-3p and miR-139-5p) markedly inhibited CRC cell growth in vitro when ectopically expressed.21963845
methylene chloride, Heart failureEpigenetic AlterationsConsistent with murine DCM caused by genetic disruption of histone deacetylases, the data implicate an inherited basis for epigenetic dysregulation in human heart failure.21965549
Mycosis FungoidesEpigenetic AlterationsAltered microRNA expression in mycosis fungoides.21966986
Hematologic Neoplasms, NeoplasmsEpigenetic AlterationsAltered expression of different microRNAs has been observed in both solid tumours and haematological malignancies.21966986
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsEpigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis.21967505
CpG Island Methylator Phenotype, Carcinogenesis, Malignant neoplasm of endometriumEpigenetic AlterationsCIMP+ is an important and frequent epigenetic event in endometrial cancer or adjacent NET, and may be a biomarker for predicting early carcinogenesis.21968189
CarcinomaEpigenetic AlterationsmicroRNAs (miRs) are endogenous small non-coding RNAs that are aberrantly expressed in various carcinomas.21971665
SchizophreniaEpigenetic AlterationsSeveral genes that were dysregulated in both individuals with schizophrenia and their siblings related to nucleosome and histone structure and function, suggesting a potential epigenetic mechanism underlying the risk state for the disorder.21972136
Breast CarcinomaEpigenetic AlterationsContribution of epigenetic alteration of BRCA1 and BRCA2 genes in breast carcinomas in Tunisian patients.21978880
Malignant neoplasm of stomachEpigenetic AlterationsEpigenetic regulation of death-associated protein kinase expression in primary gastric cancers from Chinese patients.21979297
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsPromoter methylation is an important mechanism by which tumor suppressor gene transcription is repressed in cancer cells.21979297
Dyskeratosis CongenitaEpigenetic AlterationsThe relationship between DNA methylation and telomere length in dyskeratosis congenita.21981348
Primary malignant neoplasmEpigenetic AlterationsSince the discovery of small non-coding RNAs, the analyses of microRNA (miRNA) expression patterns in human cancer have provided new insights into cancer biology.21983937
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsAssociation of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma.21983937
Malignant Neoplasms, Pancreatic carcinomaEpigenetic AlterationsmiRNA-21 has been suggested to be one of the miRNAs that have an important role in the development or biological behavior of a variety of malignancies, including pancreatic cancer.21983937
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsThe miRNA most highly expressed in pancreatic ductal adenocarcinomas (ie, miRNA-21) was further assessed by quantitative real-time reverse transcription PCR (RT-PCR) assays in the 65 pancreatic ductal adenocarcinoma cases.21983937
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsmiRNA-21 was the most significantly overexpressed miRNA in the pancreatic ductal adenocarcinomas analyzed, and was also highly expressed in 75% of the 65 pancreatic ductal adenocarcinomas examined by real-time RT-PCR.21983937
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsHigh miRNA-21 expression was correlated with a worse prognosis in the pancreatic ductal adenocarcinoma patients (P=0.045).21983937
Pancreatic Ductal Adenocarcinoma, NeoplasmsEpigenetic AlterationsOur data suggest that an overexpression of miRNA-21 is, therefore, associated with the biological behavior of pancreatic ductal adenocarcinoma via the downregulation of the expression of tumor suppressors, PDCD4 and TIMP3, thus resulting in tumor progression and the adverse clinical course of pancreatic ductal adenocarcinoma.21983937
Primary malignant neoplasmEpigenetic AlterationsMicroRNA expression is altered in cancer cells, and microRNAs could serve as diagnostic/prognostic biomarker for cancer patients.21984948
Primary malignant neoplasmEpigenetic AlterationsMicroRNA levels are distinctly increased in cancer patients, although only a small subset of circulating microRNAs has a tumor-specific origin.21984948
B-Cell LymphomasEpigenetic AlterationsSerum microRNAs are promising novel biomarkers for diffuse large B cell lymphoma.21987025
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are regulatory RNA molecules that are deregulated in many disease types, including cancer.21987025
Primary malignant neoplasmEpigenetic AlterationsRecently, miRNAs have shown promise as markers for cancer diagnosis.21987025
Diffuse Large B-Cell LymphomaEpigenetic AlterationsIn conclusion, these data suggest that serum miRNAs are potentially useful tools as novel noninvasive biomarker for the diagnosis of DLBCL.21987025
Malignant neoplasm of urinary bladder, Enrichment (technique)Epigenetic AlterationsSubsequent enrichment-based bioprocess mapping revealed alterations in phase I/II metabolism and suggested a possible role for DNA methylation in perturbing xenobiotic metabolism in bladder cancer.21990318
Stomach CarcinomaEpigenetic AlterationsWhen recombinant EBV was introduced into the EBV(-)/low-methylation epigenotype gastric cancer cell, MKN7, 3 independently established subclones displayed increases in DNA methylation.21990320
Communicable Diseases, Stomach Carcinoma, Malignant neoplasm of stomachEpigenetic AlterationsIn summary, DNA methylation profiling classified gastric cancer into 3 epigenotypes, and EBV(+) gastric cancers showed distinct methylation patterns likely attributable to EBV infection.21990320
Colorectal Cancer PathwayEpigenetic AlterationsA let-7 microRNA SNP in the KRAS 3UTR is prognostic in early-stage colorectal cancer.21994416
Clinical CoordinatorEpigenetic AlterationsRecently, a SNP in a lethal-7 (let-7) miRNA complementary site (LCS6) in the KRAS 3untranslated region was suggested to affect survival in metastatic CRC.21994416
Diabetes MellitusEpigenetic AlterationsGenome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood.21994764
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsInter-individual DNA methylation variations were frequently hypothesized to alter individual susceptibility to Type 2 Diabetes Mellitus (T2DM).21994764
Tuberculosis, PulmonaryEpigenetic AlterationsCirculating microRNAs in patients with active pulmonary tuberculosis.21998423
Tuberculosis, PulmonaryEpigenetic AlterationsIn all, for the first time our results revealed that a number of miRNAs were differentially expressed during active pulmonary tuberculosis infection, and circulating miR-29a has great potential to serve as a marker for the detection of active pulmonary tuberculosis infection.21998423
Primary malignant neoplasmEpigenetic AlterationsBased on The Cancer Genome Atlas (TCGA), discovery and validation sets with gene, microRNA, and quantitative MR-imaging data were created.21998659
Parkinson DiseaseEpigenetic AlterationsConvergence of miRNA expression profiling, a-synuclein interacton and GWAS in Parkinsons disease.22003392
nervous system disorder, Parkinson Disease, palladiumEpigenetic AlterationsmiRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinsons disease (PD).22003392
Unknown (origin) (qualifier value)Epigenetic AlterationsThese findings suggest that several miRNAs may act as regulators of both known and novel biological processes leading to idiopathic PD.22003392
Disease, Degenerative polyarthritisEpigenetic AlterationsMicroRNAs (miRNAs) are a family of non-coding RNAs that play an important role in human diseases, including osteoarthritis (OA).22006119
Degenerative polyarthritisEpigenetic AlterationsChanges in microRNA expression in peripheral mononuclear cells according to the progression of osteoarthritis.22006119
Clinical CoordinatorEpigenetic AlterationsThe DNA methylation of each marker was quantified using combined bisulfite restriction analysis (COBRA) and analyzed along with various genetic factors associated with CRC [the BRAF and KRAS mutations, MLH1 methylation and microsatellite instability (MSI)].22006538
Aortic Aneurysm, ThoracicEpigenetic AlterationsSelective microRNA suppression in human thoracic aneurysms: relationship of miR-29a to aortic size and proteolytic induction.22010139
Carcinoma of lungEpigenetic AlterationsGenome-wide analysis of DNA methylation and the gene expression change in lung cancer.22011669
Malignant NeoplasmsEpigenetic AlterationsThe recent DNA methylation studies on cancers have revealed the necessity of profiling an entire human genome and not to restrict the profiling to specific regions of the human genome.22011669
CarcinogenesisEpigenetic AlterationsIt has been suggested that genome-wide DNA methylation analysis enables us to identify the genes that are regulated by DNA methylation in carcinogenesis.22011669
Inflammation, Primary malignant neoplasmEpigenetic AlterationsA protein connected to inflammation and suggested to be involved in cancer development is cyclooxygenase-2 (COX-2) which can be inhibited by microRNA-26b (miR-26b).22017396
Malignant neoplasm of stomach stage IVEpigenetic AlterationsHowever, the mechanisms by which miRNAs regulate gastric cancer metastasis remain poorly understood.22018270
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis.22018284
Malignant neoplasm of pancreasEpigenetic AlterationsWe also analyzed the expression levels of this miRNA in microdissected (n = 15) and formalin-fixed, paraffin-embedded (FFPE) (n = 115) samples from pancreatic cancers by quantitative RT-PCR.22018284
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) have been gaining attention as new, key molecules that contribute to carcinogenesis.22018284
Secondary malignant neoplasm of liverEpigenetic AlterationsSerum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis.22018950
Disease, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) have been implicated in a variety of human diseases including cancer, and have many characteristics of an ideal biomarker most notably their inherent stability and resilience.22018950
Clinical CoordinatorEpigenetic Alterations(III) We examined the correlation between the expressions of candidate serum miRNAs with clinical parameters of CRC patients.22018950
Colorectal Cancer PathwayEpigenetic AlterationsNIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA.22018986
Breast Carcinoma, NeoplasmsEpigenetic AlterationsCaffeine and caffeic acid, major coffee constituents, have been shown to suppress mammary tumor formation in animal models and to inhibit DNA methylation in human breast cancer cells, respectively.22020403
Colorectal Cancer Pathway, Colorectal Adenomatous PolypEpigenetic AlterationsDNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polyps.22020530
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have emerged as important gene regulators and are recognized as oncogenes or tumor suppressor genes in carcinogenesis.22020746
NeoplasmsEpigenetic AlterationsccRCC cases with particular VHL germline polymorphisms were more likely to have VHL inactivation through promoter hypermethylation than through sequence alterations in tumor DNA, suggesting that the presence of these SNPs may represent an example of facilitated epigenetic variation (an inherited propensity towards epigenetic variation) in renal tissue.22022277
Colonic PolypsEpigenetic AlterationsThere are sparse data on genetic, epigenetic and vitamin D exposure in African Americans (AA) with colon polyp.22022386
Epidermal cellsEpigenetic AlterationsExpression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.22025453
Hematologic NeoplasmsEpigenetic AlterationsNext-generation sequencing identifies novel microRNAs in peripheral blood of lung cancer patients.22027949
Carcinoma of lungEpigenetic AlterationsHere, we applied high-throughput SOLiD transcriptome sequencing of miRNAs expressed in human peripheral blood of patients with lung cancer.22027949
Primary malignant neoplasmEpigenetic AlterationsIn addition, we identified 32 annotated and seven unknown miRNAs that were significantly altered in cancer patients.22027949
Carcinoma of lungEpigenetic AlterationsThese results demonstrate that deep sequencing of small RNAs bears high potential to quantify miRNAs in peripheral blood and to identify previously unknown miRNAs serving as biomarker for lung cancer.22027949
CarcinogenesisEpigenetic AlterationsOur findings highlight the possible effect of environmental exposures in carcinogenesis through DNA methylation and should have applications in prevention, molecular diagnosis, prognosis, and treatment.22028395
Colorectal CarcinomaEpigenetic AlterationsDistinct genetic and epigenetic signatures of colorectal cancers according to ethnic origin.22028395
Colorectal Cancer PathwayEpigenetic AlterationsGenetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer.22028396
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsCumulative data have shown that microRNAs (miRNA) are involved in the etiology and prognosis of colorectal cancer (CRC).22028396
Clinical Coordinator, AdenocarcinomaEpigenetic AlterationsWe analyzed the effects of seven single-nucleotide polymorphisms (SNP) in pre-miRNA genes on the prognosis of a Chinese population with 408 CRC patients with surgically-resected adenocarcinoma.22028396
Clinical CoordinatorEpigenetic AlterationsOur data suggest that genetic polymorphisms in pre-miRNA genes may impact CRC prognosis especially in patients receiving chemotherapy, a finding that warrants further independent validation.22028396
Malignant NeoplasmsEpigenetic AlterationsPolycomb group (PcG) proteins are critical epigenetic mediators of stem cell pluripotency, which have been implicated in the pathogenesis of human cancers.22028491
Primary malignant neoplasmEpigenetic AlterationsEpigenetic regulation is an important mechanism leading to cancer initiation and promotion.22029821
Vulval intraepithelial neoplasia, Squamous cell carcinoma of vulva, LINC01191 geneEpigenetic AlterationsLittle is known about the epigenetic regulation of vulvar intraepithelial neoplasia (VIN) and vulvar squamous cell cancer (VSCC).22029821
Vulvar Neoplasms, LINC01191 geneEpigenetic AlterationsThese results suggest that epigenetic regulation plays a considerable role in the transformation of VIN to invasive vulvar neoplasia.22029821
Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetic deregulation of Wnt modulators leading to aberrant signaling has been reported in adult patients with acute myeloid leukemia (AML), but its occurrence in childhood patients with AML and the role of individual modulators are unclear.22031861
Cytogenetically normal acute myeloid leukemia, Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe associations of mutations in the enhancer of trithorax and polycomb family gene ASXL1 with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression profiles in primary cytogenetically normal acute myeloid leukemia (CN-AML) are unknown.22031865
Frontotemporal Lobar DegenerationEpigenetic AlterationsAltered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations.22032330
GRN gene, Frontotemporal dementiaEpigenetic AlterationsUsing miRNA array profiling, we identified the 20 miRNAs that showed greatest evidence (unadjusted P < 0.05) of dysregulation in frontal cortex of eight FTLD-TDP patients carrying PGRN mutations when compared to 32 FTLD-TDP patients with no apparent genetic abnormalities.22032330
Progranulins, Frontotemporal Lobar Degeneration, GRN gene, Frontotemporal dementiaEpigenetic AlterationsHere we examine the role of miRNAs in FTLD patients with TAR DNA-binding protein 43 pathology (FTLD-TDP) caused by genetic mutations in the progranulin (PGRN) gene.22032330
GRN geneEpigenetic AlterationsAdditional qRT-PCR analyses showed that 5 out of 9 miRNAs (miR-922, miR-516a-3p, miR-571, miR-548b-5p, and miR-548c-5p) were also significantly dysregulated (unadjusted P < 0.05) in cerebellar tissue samples of PGRN mutation carriers, consistent with a systemic reduction in PGRN levels.22032330
GRN gene, Frontotemporal dementiaEpigenetic AlterationsOur study suggests that miRNAs may contribute to the pathogenesis of FTLD-TDP caused by PGRN mutations and provides new insight into potential future therapeutic options.22032330
Sjogrens SyndromeEpigenetic AlterationsIncreased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjogrens syndrome.22033216
SF3B1 wt AlleleEpigenetic AlterationsEpigenetic regulation of nuclear PI-PLCbeta1 signaling pathway in low-risk MDS patients during azacitidine treatment.22033492
Plexiform Neurofibroma, Neurofibromatosis 1Epigenetic AlterationsRole of noncoding RNA ANRIL in genesis of plexiform neurofibromas in neurofibromatosis type 1.22034633
Kidney Failure, AcuteEpigenetic AlterationsTo confirm the functional role of rs2151280, we used real-time quantitative reverse transcription-polymerase chain reaction to analyze the expression of cyclin-dependent kinase inhibitor 2A (CDKN2A), CDKN2B, alternate reading frame (ARF), and antisense noncoding RNA in the INK4 locus (ANRIL) in the peripheral blood of 124 NF1 patients.22034633
neurofibroma, NeoplasmsEpigenetic AlterationsIdentification of ANRIL as a modifier gene in NF1 may offer clues to the molecular pathogenesis of PNFs, particularly neurofibroma formation, and emphasizes the unanticipated role of large noncoding RNA in activation of critical regulators of tumor development.22034633
Breast CarcinomaEpigenetic AlterationsAlthough DNA methylation profiles in breast cancer have been connected to breast cancer molecular subtype, there have been no studies of the association of DNA methylation with stem cell phenotype.22037257
Breast CarcinomaEpigenetic AlterationsTaken together, these data indicate loss of klotho expression as an early event in breast cancer development, and suggest a role for DNA methylation and histone deacetylation in klotho silencing.22042362
Breast Carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic silencing of the tumor suppressor klotho in human breast cancer.22042362
Intraductal papillary mucinous neoplasmEpigenetic Alterations[MicroRNA expression pattern in intraductal papillary mucinous neoplasm].22042419
Malignant NeoplasmsEpigenetic AlterationsThe aberrant microRNA expression is commonly observed in many cancers.22042419
Pancreatic carcinomaEpigenetic AlterationsAfter applying anti-miRNA inhibitors, cell survival of four pancreatic cancer cell lines decreased by 24.5% with anti-miR-196a and by 14.2% with anti-miR-183 on average.22042419
Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatic carcinomaEpigenetic AlterationsTwo microRNAs, miR-196a and miR-183-increased in IPMN and pancreatic cancer cell lines compared with immortalized dancreatic ductal cell line.22042419
Pancreatic carcinomaEpigenetic AlterationsThe inhibitions of these microRNAs repressed cell proliferation of pancreatic cancer cell lines.22042419
Lafora DiseaseEpigenetic AlterationsTo what extent epigenetic changes play a role in the regulation of a-synuclein expression and may contribute to the aetiology of sporadic LBD is a matter of debate.22042430
Gastrointestinal Stromal TumorsEpigenetic AlterationsMicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation.22042971
Obesity, InflammationEpigenetic AlterationsThe expression of specific microRNA species in obesity, which could also target and post-transcriptionally modulate cytokine mRNA, provides new insight into possible mechanisms of how risk factors might modify periodontal inflammation and may represent novel therapeutic targets.22043006
Drug-Induced Liver DiseaseEpigenetic AlterationsCirculating microRNAs as potential markers of human drug-induced liver injury.22045675
Drug-Induced Liver DiseaseEpigenetic AlterationsThis work provides the first evidence for the potential use of miRNAs as biomarkers of human drug-induced liver injury.22045675
NeoplasmsEpigenetic AlterationsEpigenetic modifications such as methylation of CpG islands in tumor-suppressor gene promoter regions have been associated with tumor development in many human cancers.22045684
Stomach CarcinomaEpigenetic AlterationsMicroRNAs as a potential prognostic factor in gastric cancer.22046085
Small cell carcinoma of lungEpigenetic AlterationsFrequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer.22047961
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) can act as oncogenes or tumor-suppressor genes in human malignancy.22047961
Malignant Neoplasms, Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe miR-34 family is comprised of tumor-suppressive miRNAs, and its reduced expression by methylation has been reported in various cancers, including non-small cell lung cancer (NSCLC).22047961
Ventricular Septal Rupture, Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsMicroRNAs, innate immunity and ventricular rupture in human myocardial infarction.22048267
Follicular thyroid carcinoma, Follicular adenomaEpigenetic AlterationsSince microRNA (miRNA) analyses could provide new leads to malignant progression, we characterised the global miRNA expression in follicular adenoma (FA) and follicular carcinoma (FC).22049245
In situ follicular neoplasiaEpigenetic AlterationsWe conclude that follicular neoplasia is associated with major changes in miRNA expression that may promote malignant transformation by increasing the expression of transcripts encoding tumourigenic factors.22049245
Carcinoma, AdenomaEpigenetic AlterationsMoreover, miRNA profiling may facilitate the diagnosis of carcinoma vs adenoma.22049245
Follicular thyroid carcinomaEpigenetic AlterationsDown-regulation of microRNAs controlling tumourigenic factors in follicular thyroid carcinoma.22049245
Carcinoma, AdenomaEpigenetic AlterationsComparison of carcinoma and adenoma with normal thyroid revealed 150 and 107 differentially expressed miRNAs respectively.22049245
Thyroid NeoplasmEpigenetic AlterationsIntegration of the changed miRNAs with differentially expressed mRNAs demonstrated an enrichment of seed sites among up-regulated transcripts encoding proteins implicated in thyroid tumourigenesis.22049245
Squamous cell carcinoma of the head and neck, Malignant Head and Neck NeoplasmEpigenetic AlterationsGenetic polymorphisms in folate metabolism may affect the risk of head and neck cancer (HNSCC) due to its involvement in DNA methylation and synthesis.22051736
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNA) have potential as prognostic biomarkers and therapeutic targets in cancer.22052060
Malignant neoplasm of large intestine, Neoplasms, AdenomaEpigenetic AlterationsmiRNA expression profiling in tumour, adenoma and normal colorectal tissues was performed to identify tumour-related miRNAs in the course of colorectal malignant changes.22052060
NeoplasmsEpigenetic AlterationsMoreover, patients whose tumours had low miR-150 expression had shorter survival and a worse response to adjuvant chemotherapy than patients whose tumours had high miRNA expression.22052060
Primary malignant neoplasmEpigenetic AlterationsGlobal hypomethylation is one of the most consistent epigenetic changes in cancer.22055592
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsDevelopment of hepatocellular carcinoma (HCC) must be understood as a multistep process with accumulation of genetic and epigenetic alterations.22055592
Breast Carcinoma, Best Case Imputation TechniqueEpigenetic AlterationsWe analyzed the expression of several microRNAs (miRs) implicated in breast cancer (BC) pathogenesis (miR-21, miR-10b, miR17-5p, mir-31, miR-155, miR-200c, miR-18a, miR-205, and miR-27a) in 80 breast carcinomas obtained from patients with bilateral BC (biBC) and 40 cases of unilateral BC (uBC).22057972
Primary malignant neoplasmEpigenetic AlterationsDespite the well-established role of the miR-17-92 in cancer formation and progression, the contribution of each individual miRNA remains to be characterized.22065543
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs have been shown to offer great potential in both the diagnosis and prognosis of cancer.22065543
Primary malignant neoplasmEpigenetic AlterationsOur recent analyses of miRNA expression signatures showed that miR-1 and miR-133a were significantly reduced in several types of cancer.22068816
CarcinogenesisEpigenetic AlterationsTherefore, identification of novel molecular networks regulated by miRNAs may provide new insights into the underlying causes of PCa oncogenesis.22068816
Breast CarcinomaEpigenetic AlterationsAberrant expression of miRNAs was involved in various biological and pathological processes, including tumorigenesis of breast cancer.22074121
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsLeukocyte global DNA methylation levels are currently being considered as biomarkers of cancer susceptibility and have been associated with risk of several cancers.22076155
Autoimmune DiseasesEpigenetic AlterationsIncreasing evidence indicates that microRNAs (miRNAs) play a vital role in the pathogenesis of inflammatory and autoimmune diseases.22077423
Breast CarcinomaEpigenetic AlterationsLIN28: a regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer.22081076
Malignant NeoplasmsEpigenetic AlterationsA tumor-suppressor gene, let-7 microRNA (miRNA) family, is often inactivated in various human malignancies.22081076
Breast CarcinomaEpigenetic AlterationsThese results also suggest that LIN28 promotes tumorigenic activity by suppressing let-7 miRNA maturation in breast carcinoma cells.22081076
Carcinogenesis, NeoplasmsEpigenetic AlterationsMicroRNA (miR) miR-34a, -34b/c, -124-1 and -203 are tumor suppressor miRs implicated in carcinogenesis.22082000
Hemangioblastoma, Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsMiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS.22082152
methionine, HemangioblastomaEpigenetic AlterationsWe hypothesized that hemangioblastomas and Met CCRCC display distinct miRNA signatures enabling their histologic differentiation.22082152
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are noncoding cellular small RNA molecules that play an important role in cancer.22082152
methionine, HemangioblastomaEpigenetic AlterationsMiRNAs were profiled in 10 cases each of hemangioblastomas, Met CCRCC and primary CCRCC.22082152
HemangioblastomaEpigenetic AlterationsTen miRNAs had greater abundance (including miR-9 (~10-fold) and miR-135a (~7-fold)) and 39 miRNAs were lower [including miR-200a (~22-fold) and miR-200b (~12-fold)] in hemangioblastomas compared with Met CCRCC.22082152
NeoplasmsEpigenetic AlterationsMetastasis-Associated-in-Lung-Adenocarcinoma-Transcript-1 (MALAT-1) is an ncRNA that is highly expressed in several tumor types.22088988
Squamous cell carcinoma of lung, NeoplasmsEpigenetic AlterationsTumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma.22089643
Squamous cell carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsAnalysis of the microRNA (miRNA) expression signature of lung squamous cell carcinoma (lung-SCC) revealed that the expression levels of miR-133a were significantly reduced in cancer tissues compared with normal tissues.22089643
Carcinogenesis, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe identification of a tumor suppressive miRNA and the novel cancer pathways it regulates could provide new insights into potential molecular mechanisms of lung-SCC carcinogenesis.22089643
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs), highly conserved small RNA molecules, may target oncogenes and have potential as a therapeutic strategy against cancer.22098779
NeoplasmsEpigenetic AlterationsEnhanced expression of these microRNAs mimics p38a deficiency and increases tumor growth in mouse models, but it also improves the response to chemotherapeutic agents.22101765
MeningiomaEpigenetic AlterationsEpigenetic subclassification of meningiomas based on genome-wide DNA methylation analyses.22102699
Cardiovascular DiseasesEpigenetic AlterationsSequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease.22103680
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small, non-coding RNAs that can act as oncogenes or tumor suppressor genes in human cancer.22105365
Stage I Esophageal Squamous Cell Carcinoma AJCC v7Epigenetic AlterationsOverexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma.22108521
Carcinoma of lungEpigenetic AlterationsIn the identification of subjects with lung cancer, increased DNA methylation of the SHOX2 gene locus in bronchial aspirates has previously been proven to be a clinically valuable biomarker.22108652
Clinical Events DomainEpigenetic AlterationsTo facilitate the use in a diagnostic setting, a CE marked in vitro diagnostic test kit to quantify SHOX2 DNA methylation in bronchial aspirates was developed and characterized.22108652
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC.22110741
Carcinoma of lungEpigenetic AlterationsEpigenetic regulation of miR-212 expression in lung cancer.22110741
Primary malignant neoplasmEpigenetic AlterationsMany studies have shown that microRNA expression in cancer may be regulated by epigenetic events.22110741
Breast CarcinomaEpigenetic AlterationsmiRNAs (miRs), which are noncoding RNA genes, may respond to estrogen and serve as posttranscriptional regulators in tumorigenic progression, especially in breast cancer; however, only limited information about this possibility is available.22113133
Breast Carcinoma, NeoplasmsEpigenetic AlterationsmiRNA-34b as a tumor suppressor in estrogen-dependent growth of breast cancer cells.22113133
Breast CarcinomaEpigenetic AlterationsThese findings reveal that miR-34b is an oncosuppressor miRNA requiring both ER+ and wild-type p53 phenotypes in breast cancer cells.22113133
Breast CarcinomaEpigenetic AlterationsThese results improve our ability to develop new therapeutic strategies to target the complex estrogenic pathway in human breast cancer progression through miRNA regulation.22113133
Nevus cell, melanomaEpigenetic AlterationsWe analyzed the epigenetic inactivation of RASSF2 and RASSF10 in malignant melanoma (MM) of the skin, including 5 MM cell lines, 28 primary MM, 33 metastases of MM, 47 nevus cell nevi (NCN), and 22 control tissues.22113481
Vulvar Lichen Sclerosus, Lichen PlanusEpigenetic AlterationsAn autoimmune phenotype in vulvar lichen sclerosus and lichen planus: a Th1 response and high levels of microRNA-155.22113482
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsMicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma.22114136
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNA) have potential as diagnostic and prognostic biomarkers and as therapeutic targets in cancer.22114136
ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsWe sought to establish the relationship between miRNA expression and clinicopathologic parameters, including prognosis, in pancreatic ductal adenocarcinoma (PDAC).22114136
NeoplasmsEpigenetic AlterationsmiRNA profiling identified expression signatures associated with PDAC, lymph node involvement, high tumor grade, and 20 miRNAs were associated with overall survival.22114136
Prostate Cancer PathwayEpigenetic AlterationsThe expression and clinical significance of GTP-binding RAS-like 3 (ARHI) and microRNA 221 and 222 in prostate cancer.22117988
Prostate Cancer PathwayEpigenetic AlterationsWhether ARHI and microRNA 221 and 222 could be considered as biomarkers for disease progression in prostate cancer requires further investigation.22117988
Primary malignant neoplasmEpigenetic AlterationsFocal CpG island hypermethylation and diffuse genomic hypomethylation signify the changes in the DNA methylation status in cancer cells.22120154
Colorectal Cancer PathwayEpigenetic AlterationsStage-dependent differential expression of microRNAs in colorectal cancer: potential role as markers of metastatic disease.22120473
Primary malignant neoplasmEpigenetic AlterationsProteins interpreting and modifying histone methylation, such as JmjC-domain and particularly PHD-finger proteins like PHF8, are activated in subsets of PrCas and promote cancer relevant phenotypes.22120715
Prostate Cancer PathwayEpigenetic AlterationsSystematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion.22120715
Primary malignant neoplasmEpigenetic AlterationsOur study highlights subsets of epigenetic enzymes influencing different cancer cell phenotypes.22120715
Heart failureEpigenetic AlterationsThe small non-coding RNAs known as microRNAs regulate gene expression and seem to play an important role in the pathogenesis of heart failure.22120965
Heart failureEpigenetic AlterationsThe differences in microRNA levels between the two groups were characterized, and a score, based on the levels of four specific microRNAs with the most significant increase in the heart failure group (miR-423-5p, miR-320a, miR-22, and miR-92b), was defined.22120965
Heart failureEpigenetic AlterationsSerum levels of microRNAs in patients with heart failure.22120965
Heart Failure, SystolicEpigenetic AlterationsElevated serum levels of specific microRNAs: miR-423-5p, miR-320a, miR-22, and miR-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.22120965
Primary malignant neoplasm, Beckwith-Wiedemann SyndromeEpigenetic AlterationsDr Feinberg continued to perform seminal work in cancer epigenetics as a Howard Hughes investigator at the University of Michigan (MI, USA), discovering human imprinted genes and loss of imprinting in cancer, and the molecular basis of Beckwith-Wiedemann syndrome.22122634
Prostate Cancer PathwayEpigenetic AlterationsTo evaluate the prognostic significance of six epigenetic biomarkers (AIM1, CDH1, KIF1A, MT1G, PAK3, and RBM6 promoter hypermethlation) in a homogeneous group of prostate cancer patients, following radical prostatectomy (RP).22127895
Squamous cell carcinomaEpigenetic AlterationsMicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma.22132151
SERPINB3 wt AlleleEpigenetic AlterationsMiRNA expression and DNA methylation changes are a common event in OSCC, and we suggest miR-375, miR-127, miR-137, the miR-200 family and miR-205 as promising candidates for future investigations.22132151
SERPINB3 wt Allele, NeoplasmsEpigenetic AlterationsMiRNA expression patterns were consistent in healthy oral epithelium and stroma, but broadly altered in both tumor and adjacent tissue from OSCC patients.22132151
SERPINB3 wt AlleleEpigenetic AlterationsAberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers, suggesting a potential clinical application for OSCC specific miRNA signatures in oral fluids.22132151
SERPINB3 wt Allele, NeoplasmsEpigenetic AlterationsAlthough overall activated in OSCC, miR-200/miR-205 suppression in oral CSCs indicate that cell specific silencing of these miRNAs may drive tumor expansion and progression.22132151
Secondary malignant neoplasm of liver, Colorectal CarcinomaEpigenetic AlterationsDNA methylation profiles of primary colorectal carcinoma and matched liver metastasis.22132162
Colorectal CarcinomaEpigenetic AlterationsThe contribution of DNA methylation to the metastatic process in colorectal cancers (CRCs) is unclear.22132162
Secondary malignant neoplasm of liverEpigenetic AlterationsMost DNA methylation differences between primary CRCs and matched liver metastasis are due to random variation and an increase in DNA methylation density rather than de-novo inactivation and silencing.22132162
Secondary malignant neoplasm of liverEpigenetic AlterationsThus, DNA methylation changes occur for the most part before progression to liver metastasis.22132162
CarcinogenesisEpigenetic AlterationsMethylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the intracellular folate metabolism which plays an important role in carcinogenesis through DNA methylation and nucleotide synthesis.22132838
Psoriasis, DiseaseEpigenetic AlterationsAlthough miRNAs are thought to be involved in the pathogenesis of human diseases, little is known about miRNAs in psoriasis.22133505
NeoplasmsEpigenetic AlterationsData further showed increased tumour histone acetylation and decreased phosphorylated ERK protein expression.22134508
Secondary malignant neoplasm of liver, Colorectal Cancer Pathway, MIR320A gene, NeoplasmsEpigenetic AlterationsmicroRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer.22134529
MetastasisEpigenetic AlterationsThe expression profile of miRNAs in liver metastasis and primary CRC tissues was analyzed by miRNA microarrays and verified by real-time polymerase chain reaction (PCR).22134529
Clinical Coordinator, Colorectal Cancer Pathway, Secondary malignant neoplasm of liver, NeoplasmsEpigenetic AlterationsAlthough there is emerging evidence that various miRNAs function as oncogenes or tumor suppressors in colorectal cancer (CRC), the role of miRNAs in mediating liver metastasis remains unexplored.22134529
Primary malignant neoplasmEpigenetic AlterationsGermline variants in the 3 untranslated region (3UTR) of cancer genes disrupting microRNA (miRNA) regulation have recently been associated with cancer risk.22139083
Lichen PlanusEpigenetic AlterationsIncreased miRNA-146a and miRNA-155 expressions in oral lichen planus.22139425
Barrett EsophagusEpigenetic AlterationsDNA methylation profiling in Barretts esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses.22139570
Degenerative polyarthritisEpigenetic AlterationsThese included 39 miRNAs that are coexpressed with miRNA-140 (miR-140), which is known to be involved in cartilage homeostasis and osteoarthritis (OA).22143896
Degenerative polyarthritisEpigenetic AlterationsThe expression and function of microRNAs in chondrogenesis and osteoarthritis.22143896
Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNA-223 (miR-223) expression has been demonstrated to be stage-specific in B cell differentiation and associated with the outcome of chronic lymphocytic leukemia (CLL).22145958
Malignant Pleural MesotheliomaEpigenetic AlterationsAberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma.22146010
Liquid ChromatographyEpigenetic AlterationsDNA methylation of RASSF1A, p16(INK4a), RARb, MGMT and DAPK was detected in 12 (30.8%), 3 (7.7%), 11 (28.2%), 0 (0.0%) and five patients (12.8%) with MPM, and in 22 (47.8%), 14 (30.4%), 24 (52.2%), 1 (2.2%) and six patients (13.0%) with LC, respectively.22146010
Heart valve disease, Atrial FibrillationEpigenetic AlterationsInfluence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease.22147268
Right armEpigenetic AlterationsThere was no detectable effect of chronic AF on miRNA expression in LA tissue, but miRNA expression in RA was strongly influenced by AF, with 47 miRNAs (15 higher, 32 lower) showing differential expression between the AF and control sinus rhythm groups.22147268
Right armEpigenetic AlterationsVHD induced different changes in miRNA expression in LA compared with RA.22147268
Right armEpigenetic AlterationsWe conclude that VHD and AF influence miRNA expression patterns in LA and RA, but these are affected differently by disease progression and by the development of AF.22147268
Right armEpigenetic AlterationsFifty-three (12 higher, 41 lower) miRNAs were altered by VHD in LA, compared with 5 (4 higher, 1 lower) in RA tissue.22147268
ST segment elevation myocardial infarctionEpigenetic Alterations[Circulating microRNA-92a in patients with ST-segment elevation myocardial infarction].22153007
NeoplasmsEpigenetic AlterationsTaken together, our findings indicate that epigenetic silencing of PRDX1 is frequent in 1p/19q-deleted oligodendroglial tumours and likely contributes to radio- and chemosensitivity of these tumours.22158042
Ulcerative ColitisEpigenetic AlterationsArray-based identification of common DNA methylation alterations in ulcerative colitis.22159500
Ulcerative ColitisEpigenetic AlterationsTo the best of our knowledge, this work defines the first high-throughput aberrant DNA methylation profiles of the colonic mucosa of UC patients.22159500
Primary malignant neoplasmEpigenetic AlterationsAlbeit the causes remain to be understood, epigenetic alterations have been suggested to play a role in the long-term cancer risk of these patients.22159500
Colorectal Cancer PathwayEpigenetic AlterationsWe identified epigenetic alterations affecting genes putatively involved in UC disease, and in susceptibility to develop colorectal cancer.22159500
Ulcerative ColitisEpigenetic AlterationsThese epigenetic profiles provide novel and relevant knowledge on the molecular alterations associated to the UC pathology.22159500
Breast CarcinomaEpigenetic AlterationsAssociation of aberrant DNA methylation with clinicopathological features in breast cancer.22159596
Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation is responsible for the epigenetic silencing of genes associated with tumourigenesis and progression of cancer.22159596
Hollings Cancer CenterEpigenetic AlterationsEpigenetic alteration and dysregulation of several pathways including wingless-type MMTV integration site (Wnt), mitogen-activated protein kinase (MAPK) and Janus kinase and signal transducer and activator of transcription (JAK-STAT) are associated with HCC development in Gnmt knockout mice.22160218
Infection caused by Helicobacter pyloriEpigenetic AlterationsInterweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection.22161133
Neutrophil Infiltration, Polymorphonuclear Cell InfiltrateEpigenetic AlterationsAmong the 17 miRNAs, 15 were associated with the degree of neutrophil infiltration and, more prominently, the degree of mononuclear cell infiltration, according to the updated Sydney system.22161133
InflammationEpigenetic AlterationsPersistent H. pylori infection may affect the mucosal expression profiles of miRNAs via chronic inflammation mediated by proinflammatory cytokines.22161133
Carcinogenesis, Helicobacter-associated gastritisEpigenetic AlterationsUnderscoring the causal association between miRNAs and proinflammatory cytokines may provide insights into the pathogenesis of H. pylori-associated gastritis linking to gastric carcinogenesis.22161133
Carcinogenesis, Stomach NeoplasmsEpigenetic AlterationsWe previously reported that aberrant DNA methylation is an early and frequent process in gastric carcinogenesis and could be useful for the detection of gastric neoplasia.22161215
Colorectal Cancer PathwayEpigenetic AlterationsOur data suggest that the miRNA variants could affect the development of colorectal cancer in the Korean population.22161766
Malignant neoplasm of urinary bladder, Breast CarcinomaEpigenetic AlterationsThe role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.22166496
Malignant neoplasm of urinary bladderEpigenetic AlterationsThis is the first report of associations between DNA repair gene miRNA-binding site SNPs with bladder and breast cancer risk and radiotherapy outcomes.22166496
Primary malignant neoplasmEpigenetic AlterationsValproic acid (VPA) is a potential anticancer agent that belongs to a class of histone deacetylase (HDAC) inhibitors, targeting the epigenetic control of gene functions in cancer cells.22168970
Stomach CarcinomaEpigenetic AlterationsGenome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer.22169097
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsRecent studies demonstrated that in several human malignancies aberrant expression profiles of circulating microRNAs (miRNAs) anticipate great cancer diagnostic potential.22169097
Squamous cell carcinoma of esophagusEpigenetic AlterationsPlasma DNA methylation of Wnt antagonists predicts recurrence of esophageal squamous cell carcinoma.22171134
Squamous cell carcinoma of esophagusEpigenetic AlterationsTo detect the effects of plasma DNA methylation of Wnt antagonists/inhibitors on recurrence of esophageal squamous cell carcinoma (ESCC).22171134
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNAs (miRNAs) are small, noncoding RNA molecules that can be down- or upregulated in colorectal cancer and have been associated to prognosis and response to treatment.22172905
Primary malignant neoplasmEpigenetic AlterationsA specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.22172905
Primary malignant neoplasmEpigenetic AlterationsA set of 13 miRNAs is strongly associated with pCR and may represent a specific predictor of response to chemoradiotherapy in rectal cancer patients.22172905
Malignant NeoplasmsEpigenetic AlterationsWidespread epigenetic alterations are characteristic of many cancers, yet few studies have systematically analyzed epigenetic alterations of neoplastic precursors.22173550
Primary malignant neoplasmEpigenetic AlterationsRecent data suggest a link between blood leukocyte DNA methylation, and cancer risk.22173668
Clinical CoordinatorEpigenetic AlterationsThis reduced HSD17B1 expression was associated with significantly increased DNA methylation (p = 0.003) in the CpG rich region located in the 5 flanking sequence of the HSD17B1 gene in CRC in the proximal but not distal colon and rectum.22176788
Clinical CoordinatorEpigenetic AlterationsOur results showed that reduced HSD17B1 expression can be associated with DNA methylation in the 5 flanking region of HSD17B1 in CRC from the proximal colon.22176788
NeoplasmsEpigenetic AlterationsWe are the first to demonstrate that miR-574-3p is a miRNA with tumor suppressor function and that MESDC1 (which has a potential oncogenic function in BC) may be targeted by miR-574-3p.22179486
Stomach Carcinoma, Carcinogenesis, Cessation of lifeEpigenetic AlterationsGastric cancer (GC) is still a leading cause of cancer-related death worldwide, and environmental, genetic, and epigenetic DNA changes are involved in the process of gastric carcinogenesis.22179688
Carcinogenesis, InflammationEpigenetic AlterationsIf our subhypothesis regarding a mechanistic link from microorganism to carcinogenesis via inflammation and consequent aberrant DNA methylation is correct, then we should see hypermethylation of relevant genes associate with specific microbiomic profiles.22180460
Primary lymphoma of conjunctivaEpigenetic AlterationsMicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2.22183793
InitiationEpigenetic AlterationsAberrant microRNA expression is implicated in cancer initiation and progression.22183793
Primary lymphoma of conjunctivaEpigenetic AlterationsWe demonstrated that miRNAs were dysregulated in conjunctival MALT lymphoma, and dysregulation of the miR-200 family could be involved in the pathogenesis and progression of the disease.22183793
Primary malignant neoplasmEpigenetic AlterationsCirculating microRNA expression profiles may be promising biomarkers for diagnosis and assessment of the prognosis of cancer patients.22198701
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is one of major factors in cancer progression.22199344
Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran.22207181
MIR122 gene, Hepatitis B, ChronicEpigenetic AlterationsMicroRNA-122 is a liver specific microRNA and is elevated in the sera of patients with chronic hepatitis C virus infection.22209627
Acute leukemiaEpigenetic AlterationsDistinctive microRNA signature is associated with the diagnosis and prognosis of acute leukemia.22209839
Acute leukemiaEpigenetic AlterationsMicroRNAs (miRNAs) are of great importance in pathogenesis, diagnosis and prognosis of acute leukemia (AL).22209839
Malignant neoplasm of stomachEpigenetic AlterationsWe examined the genetic and epigenetic alterations of the PDCD4 gene as well as the expression of PDCD4 protein in gastric cancers.22212233
Malignant neoplasm of stomachEpigenetic AlterationsmiRNA-21 overexpression was frequently detected in gastric cancers (31 of 46, 67.4%), and there was a significant inverse correlation between miRNA-21 and PDCD4 protein expression (P = 0.029), but not between miRNA-21 and PDCD4 mRNA expression.22212233
Malignant neoplasm of stomachEpigenetic AlterationsOur data suggest that overexpression of miRNA-21 and reduced or loss of PDCD4 expression may play a role in the development and progression of gastric cancers.22212233
CholangiocarcinomaEpigenetic AlterationsArs2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing microRNA-21.22213145
Carcinoma of lung, Lung NeoplasmsEpigenetic AlterationsIn adjacent histologically normal lung from lung cancer patients (n = 120), low levels of DNA methylation of the CYP1A1 enhancer were related to high levels of smoking-induced hydrophobic DNA adduct (p < 0.03), and to the presence of TP53 or K-ras mutations in the corresponding lung tumors (p < 0.03).22213191
Primary malignant neoplasmEpigenetic AlterationsIn vitro, using a panel of cultured human lung cells, we found hypermethylation of the CYP1A1 enhancer in cancer cell lines and an inverse correlation between DNA methylation and mRNA levels (Spearman r = -0.53; p = 0.003).22213191
CarcinogenesisEpigenetic AlterationsAltogether, our results indicated that low levels of DNA methylation of the CYP1A1 enhancer in histologically normal human lung were associated with high CYP1A1 mRNA levels and with smoking-induced genetic alterations; thus, it may play a role in the initiation of lung carcinogenesis.22213191
Intrahepatic Cholangiocarcinoma, Liver carcinomaEpigenetic AlterationsExpression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance.22213236
Hepatocarcinogenesis, Hepatobiliary DisorderEpigenetic AlterationsDysregulation of microRNAs is involved in liver disease, especially hepatocarcinogenesis.22213236
Malignant NeoplasmsEpigenetic AlterationsGenomic and epigenetic alterations of the gene encoding transcription factor AP-2 epsilon (TFAP2E) are common in human cancers.22216841
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations of TFAP2E were independent of mutations in key regulatory cancer genes, microsatellite instability, and other genes that affect fluorouracil metabolism.22216841
Lung NeoplasmsEpigenetic AlterationsSimilar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposure.22217548
Malignant NeoplasmsEpigenetic AlterationsLow concentrations of EM66 found in malignant tumors are associated with reduced expression and production of SgII and SgII-derived peptides that could be ascribed to a decrease in SgII gene transcription, probably linked to p-CREB down-regulation, and to lower PC levels.22217803
Pancreatic carcinoma, melanomaEpigenetic AlterationsIn pancreatic cancer and melanoma, CXCR4 expression is regulated by DNA methylation within its promoter region.22220212
Breast CarcinomaEpigenetic AlterationsLoss of DNA methylation in the CXCR4 promoter was detected in 67% of the breast cancer analyzed.22220212
Breast CarcinomaEpigenetic AlterationsThese findings suggest that the DNA methylation status of both CXCR4 and CXCL12 genes could be used as a biomarker for prognosis in breast cancer.22220212
Breast CarcinomaEpigenetic AlterationsEpigenetic changes of CXCR4 and its ligand CXCL12 as prognostic factors for sporadic breast cancer.22220212
Colorectal CarcinomaEpigenetic AlterationsThe contribution of chromosomal instability, microsatellite instability, and epigenetic instability to the development of synchronous colorectal carcinomas is controversial.22228162
Colorectal Carcinoma, NeoplasmsEpigenetic AlterationsOur findings suggest that microsatellite instability plays a more important role than does epigenetic instability in the development of synchronous colorectal cancers, and that information regarding concordant or discordant microsatellite instability status between individual tumors might help to predict clinical outcome of synchronous colorectal cancers.22228162
GlioblastomaEpigenetic AlterationsMGMT is involved in direct DNA repair exerted by cleavage of mutagenic alkyl adducts within DNA, and its epigenetic silencing confers susceptibility to DNA-damaging alkylating agents in glioblastomas and melanomas.22228432
Breast CarcinomaEpigenetic AlterationsIn this study we have mapped the promoters of 93 breast cancer-associated miRNAs, and then looked for associations between DNA methylation of 15 of these promoters and miRNA expression in breast cancer cells.22231446
Breast CarcinomaEpigenetic AlterationsDNA methylation of both P1 and P2 was inversely associated with miR-200b expression in eight out of nine breast cancer cell lines, and in vitro methylation of both promoters repressed their activity in reporter assays.22231446
Breast CarcinomaEpigenetic AlterationsThese data suggest an association between miR-200b regulation and breast cancer subtype and a potential use of DNA methylation of miRNA promoters as a component of a suite of breast cancer biomarkers.22231446
Breast Carcinoma, MetastasisEpigenetic AlterationsMapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer.22231446
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsAlthough miRNAs have been implicated in cancer, including breast cancer, the regulation of miRNA transcription and the role of defects in this process in cancer is not well understood.22231446
Colorectal Cancer PathwayEpigenetic AlterationsGenetic and epigenetic changes have correlation with specific stages of polyp-adenocarcinoma progression and colorectal cancer histopathological changes.22234098
gastrointestinalEpigenetic AlterationsControl of epigenetic changes using histone deacetylase inhibitors (HDACi) is thought to be a promising target in therapy of gastrointestinal (GI) cancer.22234637
Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia.22234685
Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNAs (miRNAs) play a key role in chronic lymphocytic leukemia as well as in normal B cells.22234685
NeoplasmsEpigenetic Alterations5-Methylcytosine (5 mC) in genomic DNA has important epigenetic functions in embryonic development and tumor biology.22234893
Liver carcinomaEpigenetic AlterationsGenome-wide DNA methylation profiles in hepatocellular carcinoma.22234943
Malignant neoplasm of liver, Hollings Cancer CenterEpigenetic AlterationsAlterations in DNA methylation frequently occur in hepatocellular cancer (HCC).22234943
cervical cancer, NeoplasmsEpigenetic AlterationsCirculating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion.22237456
Malignant Neoplasms, cervical cancerEpigenetic AlterationsmicroRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancer patients has not been established.22237456
cervical cancerEpigenetic AlterationsThe expression of microRNA-218 was detected in the sera of 90 cervical cancer patients and 50 normal age-matched women by quantitative real-time PCR.22237456
Primary malignant neoplasmEpigenetic AlterationsIn the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001).22237456
Cervical Adenocarcinoma, MetastasisEpigenetic AlterationsMoreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis.22237456
cervical cancer, NeoplasmsEpigenetic AlterationsmicroRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion.22237456
Malignant tumor of colonEpigenetic AlterationsDNA methylation biomarker candidates for early detection of colon cancer.22238052
Primary malignant neoplasmEpigenetic AlterationsMany researchers have been looking for potential epigenetic therapeutic targets in cancer using gene expression profiling with DNA microarray approaches.22238052
palladiumEpigenetic AlterationsWe found decreased methylation of the cytochrome P450 2E1 gene and increased expression of CYP2E1 messenger RNA in PD patients brains, suggesting that epigenetic variants of this cytochrome contribute to PD susceptibility.22238121
Malignant Neoplasms, Adrenal Gland PheochromocytomaEpigenetic AlterationsThe microRNA expression changes associated with malignancy and SDHB mutation in pheochromocytoma.22241719
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules with relevance as regulators of gene expression thereby affecting crucial processes in cancer development.22242178
Breast CarcinomaEpigenetic AlterationsWe performed microarray-based miRNA profiling on whole blood of 48 early stage breast cancer patients at diagnosis along with 57 healthy individuals as controls.22242178
MIR206 wt AlleleEpigenetic AlterationsThe relative fold changes of the RT-qPCR validation were in line with the microarray data for both miRNAs, and statistically significant differences in miRNA-expression were found for miR-202.22242178
Breast CarcinomaEpigenetic AlterationsMiRNA profiling in whole blood has potential as a novel method for early stage breast cancer detection, but there are still challenges that need to be addressed to establish these new biomarkers in clinical use.22242178
Primary malignant neoplasmEpigenetic AlterationsMiRNAs offer great potential as biomarkers for cancer detection due to their remarkable stability in blood and their characteristic expression in many different diseases.22242178
Breast CarcinomaEpigenetic AlterationsThis was followed by a real-time semi-quantitative Polymerase Chain Reaction (RT-qPCR) validation in a separate cohort of 24 early stage breast cancer patients from a breast cancer screening unit and 24 age matched controls using two differentially expressed miRNAs (miR-202, miR-718).22242178
Breast CarcinomaEpigenetic AlterationsUsing the significance level of p<0.05, we found that 59 miRNAs were differentially expressed in whole blood of early stage breast cancer patients compared to healthy controls.22242178
Breast CarcinomaEpigenetic AlterationsCirculating micro-RNAs as potential blood-based markers for early stage breast cancer detection.22242178
Colorectal Cancer PathwayEpigenetic AlterationsA DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.22244828
Primary malignant neoplasmEpigenetic AlterationsAltered promoter DNA methylation, one of the most important molecular alterations in cancer, is proposed to correlate with deregulation of DNA methyltransferases, although the molecular mechanisms implicated are still poorly understood.22244828
ovarian neoplasmEpigenetic AlterationsIdentification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients.22246208
Malignant neoplasm of stomachEpigenetic AlterationsChange in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: induction of promoter demethylation and histone modification causing inhibition of Wnt signaling.22246241
Stomach CarcinomaEpigenetic AlterationsSodium butyrate (NaB) induced demethylation and histone modification at the promoter region of SFRP1/2 restoring the SFRP expression in human gastric cancer cells.22246241
Stomach CarcinomaEpigenetic AlterationsThese data suggest that aberrant epigenetic modification of SFRP genes is one of the major mechanisms by which Wnt signaling is activated in human gastric cancer cells and sodium butyrate may modulate the SFRP1/2 expression through histone modification and promoter demethylation causing anti-tumor effects.22246241
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsHowever, to date the somatic epigenetic events that occur in head and neck squamous cell carcinoma (HNSCC) tumorigenesis have not been well-defined.22246327
NeoplasmsEpigenetic AlterationsIn summary, we have shown promoter hypermethylation of the tumor suppressor genes MGMT and RASSF1A in HNSCC, suggesting that this epigenetic inactivation of TSGs may play a role in the development of HNSCC.22246327
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-34a (miR-34a) can function as a tumor suppressor in some cancers through negative regulation of gene expression.22246523
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsTumor suppressor function of PGP9.5 is associated with epigenetic regulation in prostate cancer--novel predictor of biochemical recurrence after radical surgery.22246902
Prostate Cancer PathwayEpigenetic AlterationsWe speculated that impaired regulation of PGP9.5 through epigenetic pathways is associated with the pathogenesis of prostate cancer.22246902
S100A4 protein, humanEpigenetic AlterationsEpigenetic de novo methylation of CpG islands is an important event in malignant transformation.22248274
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsThe goal of this study was to develop an assay to detect the colorectal cancer (CRC)-associated, circulation-derived, epigenetic DNA marker hypermethylated vimentin gene (mVIM) in the urine of patients with CRC.22251609
Clinical CoordinatorEpigenetic AlterationsA potential urine test for CRC screening using epigenetic markers is discussed.22251609
Non-Small Cell Lung CarcinomaEpigenetic AlterationsGenetic variations in epigenetic genes are predictors of recurrence in stage I or II non-small cell lung cancer patients.22252258
Primary malignant neoplasm, Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe assessed the association of 165 SNPs in selected epigenetic enzyme genes, DNA methyltransferases, and methyl-CpG-binding proteins with cancer recurrence in 467 patients with stage I or II NSCLC treated with either surgery alone (N = 340) or surgery plus (neo)-adjuvant chemotherapy (N = 127).22252258
Troponin T, Cardiac MuscleEpigenetic AlterationsWe compared the diagnostic performance of high-sensitivity cardiac troponin T (hs-cTnT) and cardiac enriched microRNAs (miRNAs) in patients with MI.22252325
Chest PainEpigenetic AlterationsmiRNAs and hs-cTnT were already detectable in the plasma 1 h after onset of chest pain.22252325
Malignant tumor of colonEpigenetic AlterationsThe epigenetic silencing of myopodin by hypermethylation was tested in colon cancer cells (n = 5) before and after azacitidine treatment.22252522
Squamous cell carcinomaEpigenetic AlterationsAberrant DNA methylation of tumor-related genes in oral rinse: a noninvasive method for detection of oral squamous cell carcinoma.22252571
SERPINB3 wt AlleleEpigenetic AlterationsEight of the 13 genes had significantly higher levels of DNA methylation in samples from patients with OSCC than in controls.22252571
Primary malignant neoplasmEpigenetic AlterationsThe use of microRNAs (miRNAs) as minimally-invasive biomarkers has opened new opportunities for the diagnosis of cancer, primarily because they exhibit tumor-specific expression profiles and have been commonly observed in blood of both cancer patients and healthy controls.22253921
Cardiovascular Diseases, mercaptopurineEpigenetic AlterationsQuantitative reverse transcription-polymerase chain reaction of miRNAs which have been associated with cardiovascular diseases also demonstrated significant differences in miRNA profiles between platelets and their MP.22258631
mercaptopurineEpigenetic AlterationsNotably, the main fraction of miRNA in plasma was localized in MP.22258631
Coronary Artery Disease, mercaptopurineEpigenetic AlterationsFurthermore, miRNA profiles of MP differed significantly between patients with stable and unstable coronary artery disease.22258631
mercaptopurineEpigenetic AlterationsmiRNA profiles of MP are significantly different from their maternal cells, indicating an active mechanism of selective packaging from cells into MP.22258631
Cardiovascular DiseasesEpigenetic AlterationsCirculating microRNAs (miRNAs) have attracted major interest as biomarkers for cardiovascular diseases.22258631
mercaptopurineEpigenetic AlterationsWe hypothesized that microparticles (MP) represent protective transport vehicles for miRNAs and that these are specifically packaged by their maternal cells.22258631
Cardiovascular Diseases, mercaptopurineEpigenetic AlterationsCirculating MP represent transport vehicles for large numbers of specific miRNAs, which have been associated with cardiovascular diseases.22258631
NeoplasmsEpigenetic AlterationsEpigenetic inactivation of these three important glioma-associated genes was analyzed in paired biopsy samples from 18 patients with tumour recurrence.22264301
NeoplasmsEpigenetic AlterationsTumor-specific alterations of DNA methylation in circulating DNA have been associated with tumor burden and malignant progression.22265839
Primary malignant neoplasmEpigenetic AlterationsA wealth of information indicating the potential use of DNA methylation in circulating DNA for cancer screening, prognosis and monitoring of the efficacy of anticancer therapies has emerged.22265839
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsMicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins.22266187
Malignant neoplasm of urinary bladderEpigenetic AlterationsFrequent downregulation of microRNA-449a (miR-449a) was detected in 14 human bladder cancer tissues.22266187
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTumor suppressive microRNA-133a regulates novel targets: moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma.22266319
Malignant Neoplasms, MetastasisEpigenetic AlterationsRecently, many studies suggest that microRNAs (miRNAs) contribute to the development, invasion and metastasis of various types of human cancers.22266319
Colorectal Cancer PathwayEpigenetic AlterationsPrognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes stage of colorectal cancer patients.22267128
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsDown-regulation of the novel tumor suppressor gene programmed cell death 4 (PDCD4) was demonstrated in several types of cancer and regulation by micro-RNA is gaining attention.22267128
Fibrosis, LiverEpigenetic AlterationsMicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis.22267590
Malignant neoplasm of liverEpigenetic AlterationsMicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer.22267590
Chronic liver disease, Fibrosis, LiverEpigenetic AlterationsTo explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease.22267590
Aortic Aneurysm, AbdominalEpigenetic AlterationsInhibition of microRNA-29b reduces murine abdominal aortic aneurysm development.22269326
Admitting diagnosisEpigenetic AlterationsIncreasing evidence indicates epigenetic modifications in LOAD brains, and many of the environmental factors associated with AD risk, such as heavy metals and dietary factors, are able to modify the epigenome.22272627
Clinical CoordinatorEpigenetic AlterationsWe detected 4 miRNAs (miR-143, miR-145, miR-21, and miR-106a) in the stool samples of 38 CRC patients and 13 healthy individuals.22273643
Clinical CoordinatorEpigenetic AlterationsThe detection of fecal miRNAs is a potential method for CRC diagnosis or screening.22273643
Breast CarcinomaEpigenetic AlterationsEffects of oestrogen on microRNA expression in hormone-responsive breast cancer cells.22274890
Breast CarcinomaEpigenetic AlterationsHere, we analysed changes in miRNA expression in response to oestrogen in hormone-responsive breast cancer MCF-7 and ZR-75.1 cells by microarray-mediated expression profiling.22274890
Breast CarcinomaEpigenetic AlterationsResults show that miRNAs modulated by ERa represent a novel genomic pathway to impact oestrogen-dependent processes that affect hormone-responsive breast cancer cell behaviour.22274890
Clinical Coordinator, Carcinogenesis, Colorectal Cancer PathwayEpigenetic AlterationsConsidering the important role of miRNAs in carcinogenesis, it is hypothesized here that these SNPs could also affect the individual risk of colorectal cancer (CRC).22282400
Colorectal Cancer PathwayEpigenetic AlterationsUHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression.22286757
Clinical Coordinator, NeoplasmsEpigenetic AlterationsUHRF1 is emerging as a cofactor that coordinates the epigenetic silencing of tumor suppressor genes, but its role in CRC remains elusive.22286757
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsEpigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma.22286769
MeningiomaEpigenetic AlterationsCytogenetic, molecular and epigenetic changes are all known to take place in the pathogenesis of meningiomas.22288845
Carcinogenesis, MetastasisEpigenetic AlterationsThe association of GATA5 hypermethylation with metastasis and progression-free survival of patients indicates that epigenetic alterations of GATA5 participate in renal cell carcinogenesis.22289415
Liver carcinomaEpigenetic AlterationsLarge intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression.22289527
Invasive Malignant Neoplasm, MetastasisEpigenetic AlterationsIncreasing evidence suggests that large intervening non-coding RNAs (lincRNAs) regulate key pathways in cancer invasion and metastasis.22289527
Colorectal Cancer PathwayEpigenetic AlterationsIncreased expression of microRNA-21and its association with chemotherapeutic response in human colorectal cancer.22289545
Cytogenetically normal acute myeloid leukemia, Leukemia, Myelocytic, AcuteEpigenetic AlterationsTo determine the frequency of DNMT3A mutations, their associations with clinical and molecular characteristics and outcome, and the associated gene- and microRNA-expression signatures in primary cytogenetically normal acute myeloid leukemia (CN-AML).22291079
Leukemia, Myelocytic, AcuteEpigenetic AlterationsLow accuracy of gene- and microRNA-expression signatures in predicting DNMT3A mutation status suggested that the role of these mutations in AML remains to be elucidated.22291079
diabeticEpigenetic AlterationsDNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.22293752
diabeticEpigenetic AlterationsWe uncovered 276 CpG loci affiliated to promoters of 254 genes displaying significant differential DNA methylation in diabetic islets.22293752
diabetic, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsTogether, our findings offer new insights into the intricate mechanisms of T2D pathogenesis, underscore the important involvement of epigenetic dysregulation in diabetic islets and may advance our understanding of T2D aetiology.22293752
Breast CarcinomaEpigenetic AlterationsThe miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer.22294488
Breast CarcinomaEpigenetic AlterationsOur results demonstrate alterations in miRNA expression at different stages of disease progression in breast cancer, and suggest a direct involvement of the miR-200 family and miR-9 in the metastatic process.22294488
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsIn recent years, the involvement of microRNAs (miRNAs) in cancer has become apparent, and the objective of this study was to identify miRNAs associated with breast cancer progression.22294488
Acoustic NeuromaEpigenetic AlterationsGenetic and epigenetic alterations of the NF2 gene in sporadic vestibular schwannomas.22295085
Primary malignant neoplasmEpigenetic AlterationsIn addition to genetic changes, epigenetic events, as aberrant DNA methylation and histone modification, are responsible for cancer development.22297548
NeoplasmsEpigenetic AlterationsMany tumour suppressor genes are inactivated by DNA hypermethylation, which could be utilized for identification of new epigenetic biomarkers.22297548
Malignant NeoplasmsEpigenetic AlterationsCirculating microRNA (miRNAs) have been shown to have the potential as noninvasive diagnosis markers in several types of cancers.22298030
Prostate Cancer PathwayEpigenetic AlterationsA panel of five circulating microRNAs as potential biomarkers for prostate cancer.22298030
Aggressive behaviorEpigenetic AlterationsDysregulation of circulating microRNAs and prediction of aggressive prostate cancer.22298119
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsIt is becoming increasingly evident that microRNAs (miRNAs) are associated with the development and progression of prostate cancer (PCa).22298119
CHOANAL ATRESIA, POSTERIOR, MIR20A geneEpigenetic AlterationsFour miRNAs (miR-20a, miR-21, miR-145, and miR-221) could also distinguish high versus low risk in PCa patients by DAmico score with an AUC of 0.824.22298119
Aggressive behavior, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThese preliminary data suggest that altered plasma miRNAs may be useful predictors to distinguish PCa patients with varied aggressiveness.22298119
Malignant tumor of colon, Primary malignant neoplasmEpigenetic AlterationsWe have compared DNA methylation in normal colon mucosa between patients with colon cancer and patients without cancer.22300984
Primary malignant neoplasmEpigenetic AlterationsEpigenetic differences in normal colon mucosa of cancer patients suggest altered dietary metabolic pathways.22300984
CarcinomaEpigenetic AlterationsA third miRNA, miR-375, showed marked downregulation exclusively in EACs and in none of the BM or HGD lesions, suggesting its association with progression to invasive carcinoma.22302717
Barrett EsophagusEpigenetic AlterationsThe microRNAs, MiR-31 and MiR-375, as candidate markers in Barretts esophageal carcinogenesis.22302717
Barrett EsophagusEpigenetic AlterationsTaken together, we propose miR-31 and -375 as novel candidate microRNAs specifically associated with early- and late-stage malignant progression, respectively, in Barretts esophagus.22302717
Barrett Esophagus, DysplasiaEpigenetic AlterationsWe then assessed the 26 EAC-derived miRNAs in laser microdissected biopsy pairs of Barretts metaplasia (BM)/nSQ (n = 15), and high-grade dysplasia (HGD)/nSQ (n = 14) by qPCR, to map the timing of deregulation during progression from BM to HGD and to EAC.22302717
Hepatitis CEpigenetic AlterationsDysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection.22307176
Splenic Marginal Zone B-Cell LymphomaEpigenetic AlterationsUnsupervised hierarchical clustering of miRNA expression profiles demonstrated a distinct signature of SMZL compared with the normal splenic marginal zone.22307176
Splenic Marginal Zone B-Cell Lymphoma, NeoplasmsEpigenetic AlterationsFurthermore, we identified miR-26b, a miRNA known to have tumor suppressive properties, as significantly downregulated in SMZL arising in HCV-positive patients (P=0.0016).22307176
Splenic Marginal Zone B-Cell LymphomaEpigenetic AlterationsIn conclusion, there is a characteristic dysregulation of miRNA expression in SMZL with a possible implication in its molecular tumorigenesis.22307176
NeoplasmsEpigenetic AlterationsSupervised analysis revealed differentially expressed miRNAs, including miRNAs with previously recognized tumor suppressive or oncogenic potential.22307176
Splenic Marginal Zone B-Cell LymphomaEpigenetic AlterationsFive miRNAs were found significantly overexpressed in SMZL, including miR-21, miR-155 and miR-146a, whereas seven miRNAs showed significantly reduced expression, including miR-139, miR-345, miR-125a and miR-126.22307176
Malignant neoplasm of kidneyEpigenetic AlterationsmicroRNA-155 silencing inhibits proliferation and migration and induces apoptosis by upregulating BACH1 in renal cancer cells.22307849
Stomach CarcinomaEpigenetic AlterationsMicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma.22311119
Malignant NeoplasmsEpigenetic AlterationsThe microRNA-200 (miR-200) family has been reported to induce epithelial differentiation and suppress epithelial-mesenchymal transition (EMT) by inhibiting translation of zinc finger E-box-binding homeobox (ZEB) 1 and 2 mRNAs in several types of cancers.22311119
Chronic sinusitisEpigenetic AlterationsEpigenetics of chronic rhinosinusitis and the role of the eosinophil.22311846
Primary malignant neoplasmEpigenetic AlterationsOncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling.22318752
S100A4 protein, humanEpigenetic AlterationsThe miRNA participates in a variety of biologic processes, and dysregulation of miRNA is associated with malignant transformation.22318752
Primary malignant neoplasmEpigenetic AlterationsThere were 23 miRNAs found with considerably differential expressions between six oral cancer cell lines and five lines of normal oral keratinocytes, in which, 10 miRNAs showed the highest significant difference after independent examination by reverse transcription quantitative PCR.22318752
Malignant neoplasm of mouthEpigenetic AlterationsIn conclusion, we have identified at least 10 miRNAs significantly associated with oral cancer, including the most elevated miR-10b.22318752
Liver carcinomaEpigenetic AlterationsStat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.22318941
Liver neoplasms, Hollings Cancer CenterEpigenetic AlterationsThe expression of microRNA (miR)-23a, a candidate miR targeting PGC-1a and G6PC, was up-regulated in the mouse liver tumors as well as in primary human HCC.22318941
Malignant Neoplasms, DICER1 protein, humanEpigenetic AlterationsDicer and Drosha are the main regulators of miRNA biogenesis, and deregulation of their expression has been indicated as a possible cause of miRNA alterations observed in various cancers.22320315
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAlterations in microRNAs (miRNAs) expression have been proposed to play a role in CLL pathogenesis.22320315
NeoplasmsEpigenetic AlterationsDNA methylation of CpG islands within the promoters of specific genes may play roles in tumor initiation and progression.22320963
NeoplasmsEpigenetic AlterationsThe clinical significance and tumor suppressive effect of miR-125a-3p, as well as previously reported miR-125a-5p, suggest that the functional role of another strand of the mature form miRNA cannot be ignored, at least in miR-125a biogenesis.22322911
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells.22322955
Gastric AdenocarcinomaEpigenetic AlterationsMicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma.22325466
NeoplasmsEpigenetic AlterationsRecent evidence indicates that many miRNAs function as oncogenes or tumor suppressors by negatively regulating their target genes.22325466
NeoplasmsEpigenetic AlterationsDNA methylation of HIC1 was analysed in a total of 98 tumor and 70 tumor adjacent normal specimens.22327210
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are a class of small non-coding RNAs of 19-25 nt and play important roles in gene regulation in human cancers.22331473
Carcinoma of lungEpigenetic AlterationsMicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer.22331473
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe purpose of this study is to identify miRNA expression profiles that would better predict prognosis of stage I NSCLC.22331473
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMiRNAs extracted from 527 stage I NSCLC patients were profiled on the human miRNA expression profiling v2 panel (Illumina).22331473
Squamous cell carcinoma, Adenocarcinoma of lung (disorder)Epigenetic AlterationsMiRNA expression patterns between lung adenocarcinoma and squamous cell carcinoma differed significantly with 171 miRNAs, including Let-7 family members and miR-205.22331473
MetastasisEpigenetic AlterationsTen miRNAs associated with brain metastasis were identified including miR-145*, which inhibit cell invasion and metastasis.22331473
Adenocarcinoma, Non-Small Cell Lung Carcinoma, Primary malignant neoplasmEpigenetic AlterationsThe first contained 34 miRNAs derived from 357 stage I NSCLC patients independent of cancer subtype, whereas the second containing 27 miRNAs was adenocarcinoma specific.22331473
fibrogenesisEpigenetic AlterationsComputational modeling approaches further highlight a potentially important link between HCV-associated oxidative stress and epigenetic regulatory mechanisms impacting on liver fibrogenesis.22331615
ovarian neoplasmEpigenetic Alterations[Expression and significance of microRNAs in the p53 pathway in ovarian cancer cells and serous ovarian cancer tissues].22340095
ovarian neoplasmEpigenetic AlterationsMutant p53 ovarian cancer cell line SKOV3.ipl cells were transfected with pre-microRNAs and the cell-cycle changes were detected.22340095
Malignant neoplasm of ovary, NeoplasmsEpigenetic AlterationsThis study demonstrates that the p16 gene plays a role in the progression of human ovarian cancers and the blood DNA methylation of p16 gene promoter region is a weak predictor of tumor tissue methylation status.22344043
myocardial injuryEpigenetic AlterationsCirculating microRNAs are promising new biomarkers of myocardial injury.22344502
CarcinogenesisEpigenetic AlterationsRecently, researchers have found that microRNAs play several important roles in carcinogenesis.22344713
Primary malignant neoplasmEpigenetic AlterationsThe dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in womens cancer.22346766
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation is an important cancer hallmark, yet the dynamics of DNA methylation changes in human carcinogenesis remain largely unexplored.22346766
Malignant NeoplasmsEpigenetic AlterationsMoreover, the role of DNA methylation for prediction of clinical outcome is still uncertain and confined to specific cancers.22346766
Malignant NeoplasmsEpigenetic AlterationsHere we perform the most comprehensive study of DNA methylation changes throughout human carcinogenesis, analysing 27,578 CpGs in each of 1,475 samples, ranging from normal cells in advance of non-invasive neoplastic transformation to non-invasive and invasive cancers and metastatic tissue.22346766
MIR20A geneEpigenetic AlterationsThe relative concentrations of four circulating microRNAs (miR-19a, miR-20a, miR-21, and miR-214) in blood serum were measured by TaqMan MicroRNA assays.22350790
Breast Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNAs play a role in breast cancer development and progression by post-transcriptional repression of the expression of important genes, such as the tumor suppressor gene phosphatase and tensin homolog (PTEN).22350790
Liver carcinomaEpigenetic AlterationsEpigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma.22351518
Hollings Cancer CenterEpigenetic AlterationsEpigenetic deregulation of the genes encoding the secreted frizzled-related proteins (sFRPs), the Wnt signalling antagonists, has been linked with aberrant hyperactivation of the Wnt signalling in HCC cells; however, the precise underlying mechanism remains elusive.22351518
Malignant neoplasm of liver, Hollings Cancer CenterEpigenetic AlterationsWe investigated the methylation profiles of Wnt antagonists in liver samples of different stages of HCC development and liver cancer cell lines and studied the functional impact of aberrant epigenetic silencing of sFRPs on the canonical Wnt pathway and cell viability.22351518
Thyroid GlandEpigenetic AlterationsA panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration.22351693
Bipolar DisorderEpigenetic AlterationsSelective DNA methylation of BDNF promoter in bipolar disorder: differences among patients with BDI and BDII.22353757
Bipolar DisorderEpigenetic AlterationsThe etiology of bipolar disorder (BD) is still poorly understood, involving genetic and epigenetic mechanisms as well as environmental contributions.22353757
Fibrosis AssessmentEpigenetic AlterationsSeveral miRNAs that have critical roles in tissue fibrosis and ECM metabolism have been reported.22358059
KeloidEpigenetic AlterationsHowever, regulation and function of miRNAs in keloid remain to be explored.22358059
Non-Small Cell Lung CarcinomaEpigenetic AlterationsGlobal histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients.22360506
CarcinogenesisEpigenetic AlterationsAltered expression of specific microRNAs (miRNA) is known to occur during colorectal carcinogenesis.22362069
Colorectal CarcinomaEpigenetic AlterationsHowever, little is known about the genome-wide alterations in miRNA expression during the neoplastic progression of primary colorectal cancers.22362069
Primary malignant neoplasmEpigenetic AlterationsWe identified a seven-miRNA expression signature that differentiated stage I and stage IV primary colon cancers.22362069
Malignant tumor of colonEpigenetic AlterationsWe transfected HCT-116, a highly invasive colon cancer cell line, with corresponding downregulated miRNA and demonstrated that overexpression of three miRNA (miR200c*, miR143*, and miR424*) significantly abrogated invasive potential.22362069
NeoplasmsEpigenetic AlterationsWe have identified a seven-miRNA signature that is associated with metastatic potential in the primary tumor.22362069
NeoplasmsEpigenetic AlterationsForced overexpression of three downregulated miRNA resulted in attenuation of in vitro invasion, suggesting direct tumor suppressive function and further supporting the biological importance of complementary strand miRNA.22362069
Adenocarcinoma of colonEpigenetic AlterationsComplementary strand microRNAs mediate acquisition of metastatic potential in colonic adenocarcinoma.22362069
Triple Negative Breast NeoplasmsEpigenetic AlterationsThe epigenetic silencing of the estrogen receptor (ER) by hypermethylation of the ESR1 promoter is seen predominantly in triple-negative breast cancers in Indian women.22362381
Triple-Negative Breast Cancer Finding, NeoplasmsEpigenetic AlterationsWhile the proportion of hypermethylated tumors are lower in this study than that estimated using MSP, our results support the notion of increased epigenetic deregulations in ER-negative tumors in general and TN tumors in particular.22362381
Malignant Neoplasms, Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsThe deregulation of microRNA (miRNA) is frequently associated with a variety of cancers, including hepatocellular carcinoma (HCC).22362728
Hollings Cancer CenterEpigenetic AlterationsTherefore, miR-138 may serve as a useful therapeutic agent for miRNA-based HCC therapy.22362728
Breast CarcinomaEpigenetic AlterationsIdentification of DNA methylation biomarkers is a field that provides potential for improving the clinical process of breast cancer diagnosis.22366991
Primary Neoplasm, Breast CarcinomaEpigenetic AlterationsInterestingly, DNA methylation of a novel gene OTP was detected in adjacent normal tissues even 6 cm away from primary tumors, suggesting that OTP methylation may qualify as a biomarker for the early detection of breast cancer.22366991
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsDecreased expression of repulsive guidance molecule member A by DNA methylation in colorectal cancer is related to tumor progression.22367090
Colorectal Cancer PathwayEpigenetic AlterationsHowever, the relationship between the expression levels and promoter DNA methylation status of RGMa and the clinical characteristics of colorectal cancer has not been previously reported.22367090
Breast Carcinoma, NeoplasmsEpigenetic AlterationsPlasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients.22370716
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsMesenchymal stromal cells from myelodysplastic syndrome patients showed lower DICER1 (0.65+-0.08 vs. 1.91+-0.57; P=0.011) and DROSHA (0.62+-0.06 vs. 1.38+-0.29; P=0.009) gene expression levels, two relevant endonucleases associated to microRNA biogenesis, in comparison to normal myelodysplastic syndrome.22371183
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsFurthermore, mesenchymal stromal cells from myelodysplastic syndrome patients showed an underlying microRNA repression compared to healthy controls.22371183
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsConclusions This is the first description of an impaired microRNA biogenesis in human mesenchymal stromal cells from myelodysplastic syndrome patients, where DICER1 and DROSHA gene and protein downregulation correlated to a gene and microRNA abnormal expression profile, validating the animal model results previously described.22371183
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsImpaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients.22371183
Breast CarcinomaEpigenetic AlterationsOur purpose was to identify epigenetic markers of breast cancer risk, which can be reliably measured in peripheral blood and are amenable for large population screening.22371529
Hollings Cancer CenterEpigenetic AlterationsHowever, the overexpression of microRNA-301a (miR-301a) has seldom been connected with tumorigenesis in HCC.22373864
Malignant Neoplasms, Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsMiRNAs have been connected closely with the development of cancers such as hepatocellular carcinoma (HCC).22373864
Primary malignant neoplasmEpigenetic AlterationsWe propose that this approach can be adopted for accurate analysis of other suitable circulating miRNA markers of different types of cancer.22374169
Diffuse Large B-Cell LymphomaEpigenetic AlterationsGene expression profiling (GEP) and miRNA expression profiling clearly differentiated pediatric DLBCL from BL, forming distinct clusters regardless of patient age.22374697
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe evaluation of WBC DNA methylation as a biomarker of cancer risk is of particular importance as peripheral blood is often available in prospective cohorts and easier to obtain than tumor or normal tissues.22374981
Breast CarcinomaEpigenetic AlterationsTogether, our findings indicate that WBC DNA methylation levels at ATM could be a marker of breast cancer risk and further support the pursuit of epigenome-wide association studies of peripheral blood DNA methylation.22374981
Clinical Coordinator, CarcinogenesisEpigenetic AlterationsColorectal (CRC) carcinogenesis through various morphological stages has been linked to several genetic and epigenetic changes.22376079
Malignant Neoplasms, Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, Primary malignant neoplasmEpigenetic AlterationsOur expression signatures of human cancers including head and neck squamous cell carcinoma (HNSCC) demonstrated that downregulation of microRNA-133a (miR-133a) were frequently observed in cancer cells.22378351
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsNovel molecular targets regulated by tumor suppressors microRNA-1 and microRNA-133a in bladder cancer.22378464
Malignant neoplasm of urinary bladder, Primary malignant neoplasm, Best Case Imputation TechniqueEpigenetic AlterationsOur expression signatures of human cancer including bladder cancer (BC) revealed that the expression of microRNA-1 (miR-1) and microRNA-133a (miR-133a) is significantly reduced in cancer cells.22378464
SclerodermaEpigenetic AlterationsTGF-b-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts.22379029
Sample Size CalculationEpigenetic AlterationsmiR-196a inhibitor leads to the overexpression of type I collagen in normal fibroblasts, whereas overexpression of the miRNA resulted in the downregulation of type I collagen in SSc fibroblasts.22379029
SF3B1 wt AlleleEpigenetic AlterationsSeveral genetic/epigenetic abnormalities are deeply associated with the pathogenesis of MDS.22382018
SF3B1 wt AlleleEpigenetic AlterationsHere, we report that circulating cell-free DNAs from plasma and serum of patients with MDS can be used to detect genetic/epigenetic abnormalities.22382018
Stomach CarcinomaEpigenetic AlterationsH. pylori eradication improved miRNA dysregulation, but not in intestinal metaplastic glands or in the gastric mucosa of patients in a high-risk group for gastric cancer.22382634
Stomach CarcinomaEpigenetic AlterationsMany microRNAs (miRNAs) are differentially expressed in Helicobacter pylori-infected gastric mucosa and in gastric cancer tissue.22382634
Stomach CarcinomaEpigenetic AlterationsWe aimed to compare the effect of H. pylori eradication on gastric mucosal miRNAs in subjects in a high-risk group for gastric cancer compared to controls.22382634
Primary malignant neoplasmEpigenetic AlterationsThe expression of oncogenic miRNAs (miR-17/92 and the miR-106b-93-25 cluster, miR-21, miR-194, and miR-196) was significantly higher in the gastric mucosa of the cancer group than in the controls.22382634
Chronic Obstructive Airway DiseaseEpigenetic AlterationsMicroRNA-199a-5p is associated with hypoxia-inducible factor-1a expression in lungs from patients with COPD.22383663
Chronic Obstructive Airway DiseaseEpigenetic AlterationsHowever, the role of miRNAs associated with these genes in lungs from patients with COPD is unknown.22383663
Chronic Obstructive Airway DiseaseEpigenetic AlterationsThese data suggest that miR-34a and miR-199a-5p contribute to the pathogenesis of COPD, and these miRNAs may also affect the HIF-1a-dependent lung structure maintenance program.22383663
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNA) have been implicated to play an important role in the pathogenesis of a variety of cancers.22386240
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe level of these miRNA targets in urine has the potential to be developed as noninvasive markers for bladder cancer.22386240
Malignant neoplasm of urinary bladderEpigenetic AlterationsExpression of microRNAs in the urine of patients with bladder cancer.22386240
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe urinary level of these miRNAs may be developed as noninvasive markers for bladder cancer.22386240
Non-Small Cell Lung CarcinomaEpigenetic AlterationsSerum microRNA biomarkers for detection of non-small cell lung cancer.22389695
Non-Small Cell Lung CarcinomaEpigenetic AlterationsReceiver operating characteristic curves (ROC) and area under the curve were used to identify differentially expressed miRNA pairs that could distinguish NSCLC from healthy controls.22389695
Non-Small Cell Lung CarcinomaEpigenetic AlterationsSelected miRNA candidates were further validated in sera from an additional 55 NSCLC patients and 75 healthy controls.22389695
Non-Small Cell Lung CarcinomaEpigenetic AlterationsExamination of miRNA expression levels in serum from a multi-institutional cohort of 50 subjects (30 NSCLC patients and 20 healthy controls) identified differentially expressed miRNAs.22389695
Non-Small Cell Lung CarcinomaEpigenetic AlterationsUpon further testing on additional 130 subjects (55 NSCLC and 75 healthy controls), this miRNA pair predicted NSCLC with a specificity of 84% (95% CI 0.73-0.91), sensitivity of 100% (95% CI; 0.93-1.0), NPV of 100%, and PPV of 82%.22389695
Non-Small Cell Lung CarcinomaEpigenetic AlterationsA combination of two differentially expressed miRNAs miR-15b and miR-27b, was able to discriminate NSCLC from healthy controls with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 100% in the training set.22389695
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese data provide evidence that serum miRNAs have the potential to be sensitive, cost-effective biomarkers for the early detection of NSCLC.22389695
Metabolic Syndrome XEpigenetic AlterationsEpigenetic regulation of COMT may further influence the prevalence of metabolic syndrome in these patient populations.22391769
Primary malignant neoplasmEpigenetic AlterationsIt has been suggested that the presence of single nucleotide polymorphisms (SNPs) in miRNAs can alter miRNA processing, expression, and/or binding to target mRNA and represent another type of genetic variability that can contribute to susceptibility to cancer development in humans.22393998
Leukemia, Myelomonocytic, ChronicEpigenetic AlterationsEffects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.22395470
Myeloid LeukemiaEpigenetic AlterationsTET2 mutations are common in myeloid leukemia and were proposed to contribute to leukemogenesis through DNA methylation.22395470
Leukemia, Myelomonocytic, Chronic, Myeloid LeukemiaEpigenetic AlterationsUsing bisulfite pyrosequencing, global methylation measured by the LINE-1 assay and DNA methylation levels of 10 promoter CpG islands frequently abnormal in myeloid leukemia were not different between TET2 mutants and wild-type CMML cases.22395470
Colorectal Cancer PathwayEpigenetic AlterationsThe predictive value of microRNA-126 in relation to first line treatment with capecitabine and oxaliplatin in patients with metastatic colorectal cancer.22397399
Refractory Cytopenia of ChildhoodEpigenetic AlterationsGlobal histone methylation levels may help to identify RCC patients with poor prognosis.22399607
Breast CarcinomaEpigenetic AlterationsEpigenetics, particularly DNA methylation, has recently been shown to be important in breast cancer initiation.22402307
Sample Size CalculationEpigenetic AlterationsmiR-129-5p, one of the downregulated microRNAs in SSc fibroblasts, increased due to IL-17A and mediated the a1(I) collagen reduction.22403442
NeoplasmsEpigenetic AlterationsThe miRNA levels in the different groups reflected pathological tumor progression.22406928
NeoplasmsEpigenetic AlterationsAn assay of serum miR-17-5p/20a levels showed that the levels of serum miRNAs were notably reduced in post-treated mice with tumor volume regression.22406928
Stomach CarcinomaEpigenetic AlterationsClinicopathological and prognostic significance of microRNA-107 and its relationship to DICER1 mRNA expression in gastric cancer.22407237
Invasive Malignant Neoplasm, MetastasisEpigenetic AlterationsIt is known that miRNA-107 (miR-107) promotes cancer invasion and metastasis.22407237
Non-Small Cell Lung Carcinoma, Primary malignant neoplasmEpigenetic AlterationsThe weak increase of both APIP and UACA mRNA levels in the 5-aza-2-deoxycytidine-treated NSCLC cells indicates that mechanisms other than DNA methylation are involved in the regulation of APIP and UACA gene expression in these cancer cells.22407486
Liver carcinomaEpigenetic AlterationsCharacteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma.22407776
HepatocarcinogenesisEpigenetic AlterationsEpigenetic inactivation of a subset of TSGs plays a critical role in the earliest steps of hepatocarcinogenesis.22407776
Carcinogenic Chlorinated Hydrocarbon, Hollings Cancer CenterEpigenetic AlterationsFurthermore, epigenetic inactivation of these genes in CHC provides a prognostic value for determining the risk for developing HCC later in life.22407776
AMD1 wt AlleleEpigenetic AlterationsThe evidence presented suggests that GSTM1 and GSTM5 undergo epigenetic repression in AMD RPE/choroid, which may increase susceptibility to oxidative stress in AMD retinas.22410570
Liver CirrhosisEpigenetic AlterationsIn contrast, alterations in serum levels of miR-652 were stage-independent, reflecting a concordant down-regulation of this miRNA in circulating monocytes of patients with liver cirrhosis, which was inducible by proinflammatory stimuli like bacterial lipopolysaccharide.22412969
Liver CirrhosisEpigenetic AlterationsMicro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis.22412969
Chronic liver diseaseEpigenetic AlterationsMicro-RNAs (miRNAs) have recently emerged as crucial modulators of molecular processes involved in chronic liver diseases.22412969
Liver CirrhosisEpigenetic AlterationsThe few miRNAs with previously proposed roles in liver cirrhosis were identified in screening approaches on liver parenchyma, mostly in rodent models.22412969
Prostate carcinomaEpigenetic AlterationsEpigenetic down regulation of RASSF10 and its possible clinical implication in prostate carcinoma.22415519
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThis is the first study, which demonstrates the frequent epigenetic inactivation of RASSF10 in PCa and its implication in clinical symptoms of PCa.22415519
Breast DiseasesEpigenetic AlterationsThe DNA methylation level in 1,505 CpG-sites was similar in samples from patients with benign breast disorders and lymphogenous metastases.22416386
Breast Carcinoma, MetastasisEpigenetic Alterations[Epigenetic aspects of early lymphogenic metastasis in breast cancer].22416386
Coronary Artery Disease, HypercholesterolemiaEpigenetic AlterationsABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia.22419126
Carcinoma of lung, NeoplasmsEpigenetic AlterationsIn conclusion, inactivation of TROP2 due to LOH or by DNA methylation may play an important role in lung cancer tumourigenicity through losing its suppressive effect on IGF-1R signalling and tumour growth.22419550
Metabolic DiseasesEpigenetic AlterationsThese novel associations between global LINE-1 DNA methylation and blood glycaemic and lipid profiles highlight a potential role for epigenetic biomarkers as predictors of metabolic disease and may be relevant to future diagnosis, prevention and treatment of this group of disorders.22422454
Malignant neoplasm of urinary bladder, Carcinogenesis, NeoplasmsEpigenetic AlterationsAltered microRNA (miRNA) expression may occur early in bladder cancer and may play a role in carcinogenesis and tumor behavior.22426337
Bladder NeoplasmEpigenetic AlterationsWe evaluated whether alterations in miRNA expression could improve disease stratification and outcome prognosis in bladder tumors and noninvasive diagnosis in urinary samples.22426337
Carcinoma, NeoplasmsEpigenetic AlterationsTumor miRNA expression by RT-qPCR correlated with tumor grade, size, and presence of carcinoma in situ for miR-222, recurrence (miR-222 and miR-143), progression (miR-222 and miR-143), disease-specific survival (miR-222), and overall survival (miR-222).22426337
Bladder Neoplasm, NeoplasmsEpigenetic AlterationsThus, bladder tumors were characterized by changes in miRNA expression that could aid in tumor stratification and clinical outcome prognosis, and miRNAs were detected in urinary specimens for noninvasive diagnosis.22426337
Malignant tumor of colon, NeoplasmsEpigenetic AlterationsTumor microRNA-29a expression and the risk of recurrence in stage II colon cancer.22426940
Malignant tumor of colonEpigenetic AlterationsThere is emerging evidence for the prognostic role of various microRNA (miRNA) molecules in colon cancer.22426940
Terminal illnessEpigenetic AlterationsThe study population included 110 patients, 51 (46%) with stage I and 59 (54%) with stage II disease, who underwent curative colectomies between 1995 and 2005 without adjuvant therapy and for whom reliable miRNA expression data were available.22426940
Clinical CoordinatorEpigenetic AlterationsIn addition, we analyzed the DNA methylation of the sixth CTCF-binding site in the DMR of IGF2/H19 in 81 CRC patients using bisulfate sequencing.22427002
NeoplasmsEpigenetic AlterationsTumour genetic and epigenetic features differ by tumour location.22427238
diabeticEpigenetic AlterationsIn conclusion, these findings show a dysregulation of miRNAs in HF, shedding light on the specific disease mechanisms differentiating diabetic patients.22427379
Malignant neoplasm of kidneyEpigenetic AlterationsMicroRNA 15a, inversely correlated to PKCa, is a potential marker to differentiate between benign and malignant renal tumors in biopsy and urine samples.22429968
Renal Cell CarcinomaEpigenetic AlterationsAn identical system can be identified in renal carcinomas, in which, after nuclear transmigration, PKCa binds directly to pri-miRNA 15a in the nucleus.22429968
Refractory Cytopenia of ChildhoodEpigenetic AlterationsConversely, miRNA 15a is up-regulated in RCC and down-regulated in oncocytoma.22429968
Cystitis, Refractory Cytopenia of Childhood, NeoplasmsEpigenetic AlterationsUp-regulated miRNA 15a can be measured in urine from patients with RCC but is nearly undetectable in oncocytoma, other tumors, and urinary tract inflammation.22429968
DiseaseEpigenetic AlterationsIncreasing evidence shows that single nucleotide polymorphisms (SNPs) or mutations in microRNAs (miRNAs) sequence may affect the processing and function of miRNAs and participate in the occurrence of diseases.22430032
PathologyEpigenetic AlterationsAssociation between the miRNA signatures in plasma and bronchoalveolar fluid in respiratory pathologies.22430188
Carcinoma of lung, Malignant neoplasm of lungEpigenetic AlterationsThe measurement of miRNA expression through less invasive techniques such as plasma and serum have been suggested to analysis of several lung malignancies including lung cancer.22430188
Respiration DisordersEpigenetic AlterationsThis finding supports that the miRNAs profiles obtained from different biological samples have to be carefully validated to link with respiratory diseases.22430188
NeoplasmsEpigenetic AlterationsDNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract.22430803
NeoplasmsEpigenetic AlterationsThis study identifies aberrant DNA methylation patterns in UADT cancers and suggests a potential mechanism by which environmental factors may deregulate key cellular genes involved in tumor suppression and contribute to UADT cancers.22430803
Malignant Head and Neck NeoplasmEpigenetic AlterationsThis profile demonstrates the potential of DNA methylation measured in blood for development of non-invasive applications for detection of head and neck cancer.22430805
Chronic Lymphocytic LeukemiaEpigenetic AlterationsMonoallelic and biallelic deletions of 13q14.3 in chronic lymphocytic leukemia: FISH vs miRNA RT-qPCR detection.22431542
Malignant NeoplasmsEpigenetic AlterationsA single nucleotide polymorphism located in the 3-untranslated region of the KRAS oncogene (KRAS variant; rs61764370) disrupts a let-7 miRNA binding and was recently reported to act as a genetic marker for increased risk of developing human cancers.22436609
DyspepsiaEpigenetic AlterationsGenetic polymorphism of pri-microRNA 325, targeting SLC6A4 3-UTR, is closely associated with the risk of functional dyspepsia in Japan.22438098
Breast Carcinoma, Mammary NeoplasmsEpigenetic AlterationsmicroRNA expression signatures can differentiate normal and breast cancer tissues and can define specific clinico-pathological phenotypes in breast tumors.22438871
Breast CarcinomaEpigenetic AlterationsImportantly, the role of 43 of these microRNAs has not been previously reported in breast cancer, including several evolutionary conserved microRNA*, showing similar expression rates to that of their corresponding leading strand.22438871
CarcinogenesisEpigenetic AlterationsPathway analysis identified that some biological process which are important in breast carcinogenesis are affected by the altered microRNA expression, including signaling through MAP kinases and TP53 pathways, as well as biological processes like cell death and communication, focal adhesion and ERBB2-ERBB3 signaling.22438871
Breast CarcinomaEpigenetic AlterationsIdentification and pathway analysis of microRNAs with no previous involvement in breast cancer.22438871
NeoplasmsEpigenetic AlterationsThe expression of 14 microRNAs was replicated in an independent set of 55 tumors.22438871
Breast CarcinomaEpigenetic AlterationsOur data identified the altered expression of several microRNAs whose aberrant expression might have an important impact on cancer-related cellular pathways and whose role in breast cancer has not been previously described.22438871
Mammary NeoplasmsEpigenetic Alterations130 miRNAs showed significant differential expression (adjusted P value = 0.05, Fold Change = 2) in breast tumors compared to the normal adjacent tissue.22438871
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsSalivary rinses have been recently proposed as a valuable resource for the development of epigenetic biomarkers for detection and monitoring of head and neck squamous cell carcinoma (HNSCC).22438973
SERPINB3 wt Allele, MetastasisEpigenetic AlterationsThis study demonstrates that downregulation of 7 miRNA associated with advanced stage, 6 miRNAs with metastasis and 2 with poor prognosis in SCCC.22438992
Small cell carcinoma of the cervix, MetastasisEpigenetic AlterationsDownregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix.22438992
Neoplasm MetastasisEpigenetic AlterationsUsing the GeneCopoeia All-in-One(tm) Customized Human qPCR Primer Array, the expression profiles of 30 miRNAs associated with tumor metastasis was obtained from the formalin-fixed paraffin embedded samples of all 44 patients.22438992
MicroRNA 105, SERPINB3 wt Allele, Federation of Gynecology and ObstetricsEpigenetic AlterationsSeven miRNAs, has-let-7c, has-miR-10b, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p were significantly down-regulated in advanced stage SCCC patients (FIGO IB2-IV) compared to early stage SCCC patients (FIGOIB1).22438992
MicroRNA 105, SERPINB3 wt Allele, MetastasisEpigenetic AlterationsAmong, downregulation of six miRNAs, has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p were significantly associated with lymph node metastasis and reduced survival in SCCC.22438992
SERPINB3 wt AlleleEpigenetic AlterationsFunctional analysis of these miRNAs may enhance our understanding of SCCC, as altered expression of specific miRNAs may regulate the metastatic pathway and provide novel targets for therapy.22438992
Malignant Neoplasms, Breast CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) are small non-coding RNAs playing significant role in the pathogenesis of many cancers including breast cancer.22439831
Triple-Negative Breast Cancer FindingEpigenetic AlterationsTherefore, miRNAs are also potential prognostic and/or predictive biomarkers in triple-negative breast cancer patients.22439831
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been recently described as powerful circulating biomarkers in a wide range of solid cancers.22440013
Refractory Cytopenia of ChildhoodEpigenetic AlterationsWe identified 30 miRNAs differentially expressed between serum of RCC patients and healthy controls: 19 miRNAs were up-regulated and 11 miRNAs were down-regulated in RCC patients.22440013
Refractory Cytopenia of ChildhoodEpigenetic AlterationsCirculating miRNAs in serum are promising biomarkers in RCC.22440013
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsRecent studies have shown that deregulated expression of microRNAs (miRNAs) contributes to the initiation and progression of PCa.22442719
Aggressive behavior, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsAmong several known miRNAs, let-7 family appears to play a key role in the recurrence and progression of PCa by regulating CSCs; however, the mechanism by which let-7 family contributes to PCa aggressiveness is unclear.22442719
Multiple MyelomaEpigenetic AlterationsCirculating microRNA expression is associated with genetic subtype and survival of multiple myeloma.22447484
Esophageal carcinomaEpigenetic AlterationsTo explore the epigenetic changes and the function of TFPI-2 in esophageal cancer.22449186
Alzheimers DiseaseEpigenetic AlterationsGenome-wide DNA methylation differences between late-onset Alzheimers disease and cognitively normal controls in human frontal cortex.22451312
Alzheimers Disease", Loading TechniqueEpigenetic AlterationsEvidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset Alzheimers disease (LOAD), but little has been done on a genome-wide scale to identify potential sites involved in disease.22451312
Loading TechniqueEpigenetic AlterationsIdentification of epigenetic biomarkers of LOAD risk may allow for the development of novel diagnostic and therapeutic targets.22451312
Primary malignant neoplasmEpigenetic AlterationsOncogenic miRNAs, including two miRNA clusters, miR-17-92a and miR-106b-25 cluster, were upregulated in cancer stromal tissues compared with normal stroma.22452939
Primary malignant neoplasmEpigenetic AlterationsAlthough further validation is required, the finding that stromal miRNA expression levels were associated with clinicopathologic factors suggests the possibility that miRNAs in cancer stroma are crucially involved in cancer progression.22452939
Primary malignant neoplasmEpigenetic AlterationsOncogenic miRNAs were highly expressed in cancer stroma.22452939
Malignant NeoplasmsEpigenetic AlterationsAberrant expression of MicroRNAs is considered to participate in occurrence and progression of human cancers.22455393
Breast Carcinoma, NeoplasmsEpigenetic AlterationsClaudin-6 is a candidate tumor suppressor gene in breast cancer, and has been shown to be regulated by DNA methylation and histone modification in breast cancer lines.22455563
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-372 is associated with poor prognosis in colorectal cancer.22456107
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsAberrant DNA methylation has been implicated in the development of hepatocellular carcinoma (HCC).22457049
NeoplasmsEpigenetic AlterationsMeanwhile, the reduced expression of two miRNAs in tumor patient was supposed to have a trend of lymph node metastases.22457808
NeoplasmsEpigenetic AlterationsIt showed a significant correlation between these two miRNAs expression both in tissues and tumor cell lines.22457808
Eyelid Sebaceous Gland CarcinomaEpigenetic AlterationsEpigenetic inactivation of the E-cadherin gene in eyelid sebaceous gland carcinoma.22458737
Eyelid Sebaceous Gland CarcinomaEpigenetic AlterationsEpigenetic inactivation of the E-cadherin gene causes loss of membrane-bound E-cadherin and could contribute to the reduced disease-free survival in eyelid sebaceous gland carcinoma.22458737
Coronary Artery DiseaseEpigenetic Alterations[The influence of statin therapy on circulating microRNA-92a expression in patients with coronary heart disease].22464573
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsMicroRNA expression aids the preoperative diagnosis of pancreatic ductal adenocarcinoma.22466166
Pancreatic Ductal Adenocarcinoma, PancreasEpigenetic AlterationsPancreatic ductal adenocarcinomas show differential expression of miRNAs compared to benign pancreatic lesions.22466166
PancreasEpigenetic AlterationsA select panel of miRNAs aids the distinction between pancreatic lesions in cytology specimens.22466166
Clinical Coordinator, NeoplasmsEpigenetic AlterationsThese findings indicate that miR-378, miR-375, miR-422a and miR-215 play an important role in CRC as tumour suppressors, whereas miR-135b functions as an oncogene; both groups of miRNA contribute to CRC pathogenesis.22469014
Colorectal Cancer PathwayEpigenetic AlterationsIdentification and functional screening of microRNAs highly deregulated in colorectal cancer.22469014
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) constitute a robust regulatory network with post-transcriptional regulatory efficiency for almost one half of human coding genes, including oncogenes and tumour suppressors.22469014
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsWe determined the expression profile of 667 miRNAs in colorectal cancer (CRC) tissues and paired non-tumoural tissues and identified 42 differentially expressed miRNAs.22469014
Primary malignant neoplasmEpigenetic AlterationsAn altered expression of microRNAs (miRNAs) contributes both to the development of cancer and to the progression of the disease.22470130
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMalignant tumours and tumour cell lines have widespread deregulated expressions of miRNAs compared to normal tissues.22470130
Glioblastoma MultiformeEpigenetic AlterationsWe show that the expression profiles of 10 miRNAs can distinguish primary from secondary glioblastoma types.22470130
GlioblastomaEpigenetic AlterationsIn conclusion, the expression patterns of different miRNAs characterise primary and secondary glioblastomas.22470130
SERPINB3 wt AlleleEpigenetic AlterationsObservational assessment of DNA copy number, miRNA, and RNA expression in primary and metastatic OSCC.22470160
MetastasisEpigenetic AlterationsAmong these unique miRNAs, miR-140-3p, miR-29c, and miR-29a were differentially expressed in metastasis versus nonmetastatic samples and had a strong positive correlation with their DNA copy numbers and a negative correlation with the expression of their target genes.22470160
Neoplasm MetastasisEpigenetic AlterationsResults suggest that DNA copy number aberration may play a role in the dysregulation of some differentially expressed miRNAs in OSCC metastasis, warranting further investigation.22470160
Stomach CarcinomaEpigenetic AlterationsStathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer.22470493
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAnalysis of the DNA methylation profile of the CRY1 promoter in a subgroup of 57 patients revealed that CRY1 expression in LR CLL cells is silenced by aberrant promoter CpG island hypermethylation.22470559
Chronic Lymphocytic LeukemiaEpigenetic AlterationsEpigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia.22470559
Malignant Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsWe also compared the CRY1 expression in CLL with other lymphoid malignancies and observed epigenetic silencing of CRY1 in a patient with B cell acute lymphoblastic leukemia (B-ALL).22470559
Carcinoma of lungEpigenetic AlterationsExpression of A/B/H blood group antigens was not detected in lung cancer tissues, which may have resulted from down-regulation of ABO/FUT2 gene transcription.22471454
Carcinoma of lungEpigenetic AlterationsEffects of ABO and FUT2 genetic transcription absence on ABH histo-blood group antigen expression in lung cancer patients.22471454
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer (CRC) patients; however, only a little is known about its functional role in CRC.22476768
Breast CarcinomaEpigenetic AlterationsMicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer.22476851
Breast CarcinomaEpigenetic AlterationsHowever, prognostic markers and the outcome prediction of the miRNA signature in breast cancer patients have not been comprehensively assessed.22476851
Primary malignant neoplasmEpigenetic AlterationsRecent studies have suggested that specific microRNAs (miRNAs) may play important roles in the development of cancer cells.22476851
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe expression of heparanase and microRNA-1258 in human non-small cell lung cancer.22488243
Mantle cell lymphomaEpigenetic AlterationsGenome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis.22490335
Mantle cell lymphoma, Medial collateral ligamentEpigenetic AlterationsmiRNA deregulation has been implicated in the pathogenesis of mantle cell lymphoma (MCL).22490335
Medial collateral ligament, Aggressive Non-Hodgkin LymphomaEpigenetic AlterationsWe identified a 19-miRNA classifier that included 6 up-regulated miRNAs and 13 down regulated miRNA that was able to distinguish MCL from other aggressive lymphomas.22490335
Medial collateral ligament, LymphomaEpigenetic AlterationsThis miRNA classifier showed consistent results in formalin-fixed paraffin-embedded tissues and was able to distinguish cyclin D1-negative MCL from other lymphomas.22490335
Medial collateral ligament, B Lymphoblastic Leukemia/LymphomaEpigenetic AlterationsA 26-miRNA classifier could distinguish MCL from small lymphocytic leukemia/lymphoma, dominated by 23 up-regulated miRNAs in MCL.22490335
Medial collateral ligamentEpigenetic AlterationsUnsupervised hierarchical clustering of MCL patients demonstrated a cluster characterized by high expression of miRNAs from the polycistronic miR17-92 cluster and its paralogs, miR-106a-363 and miR-106b-25, and associated with high proliferation gene signature.22490335
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are non-coding RNAs that have been shown to be aberrantly expressed in several tumor types.22492279
NeoplasmsEpigenetic AlterationsOf these miRNAs, miR-22 as tumor suppressor has been shown to play a crucial role in human carcinogenesis.22492279
Renal Cell Carcinoma PathwayEpigenetic AlterationsIdentification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients.22492545
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) constitute a robust regulatory network with posttranscriptional regulatory efficiency for almost one-half of human coding genes, including oncogenes and tumor suppressors.22492545
Neoplasms, Refractory Cytopenia of ChildhoodEpigenetic AlterationsTo identify potential prognostic miRNAs, we analyzed expression profiles in tumors of different prognostic groups of RCC patients.22492545
Neoplasms, Refractory Cytopenia of ChildhoodEpigenetic AlterationsWe identified tumor relapse-signature based on the expression of 64 miRNAs differentially expressed between relapse-free RCC patients and RCC patients who developed relapse (20 miRNAs were increased, 44 miRNAs were decreased).22492545
Refractory Cytopenia of ChildhoodEpigenetic AlterationsIf further validated, we suggest that identified miRNAs might be used for identification of RCC patients at high risk of early relapse after nephrectomy in clinical practice.22492545
Endometrial disorderEpigenetic AlterationsEvidence suggests that a number of microRNA (miRNA) are aberrantly expressed in endometrial disorders with potential posttranscriptional regulation of their specific target genes, including ovarian steroid receptors.22492871
NeuroblastomaEpigenetic AlterationsIn neuroblastoma caspase-8 is frequently silenced by DNA methylation.22493319
Functional disorder, Carcinoma of lungEpigenetic AlterationsLysine specific demethylase 1 (LSD1) has been identified and biochemically characterized in epigenetics, but the pathological roles of its dysfunction in lung cancer remain to be elucidated.22493729
Prostate Cancer PathwayEpigenetic AlterationsUsing whole genome expression profiling and whole genome methylation profiling, we have determined the genome-wide differences in genetic and epigenetic responses to genistein in prostate cancer cells before and after undergoing the EMT.22494660
Barrett EsophagusEpigenetic AlterationsmicroRNA-145 in Barretts oesophagus: regulating BMP4 signalling via GATA6.22504665
sq. inEpigenetic AlterationsThree unique miRNA expression profiles were found in tissue from EAC, BE and SQ, which showed that miRNA-145 was upregulated in BE compared with EAC and SQ.22504665
Pancreatic carcinomaEpigenetic AlterationsDifferential signature of fecal microRNAs in patients with pancreatic cancer.22504911
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThese findings suggest that fecal microRNAs such as miR-181b and miR-210 may have potential to be used as new biomarkers for PCa screening.22504911
Colorectal Cancer PathwayEpigenetic AlterationsHowever, whether DNA methylation at the displacement loop (D-loop) region of mitochondrial DNA (mtDNA) has an effect on the expression of the rate-limiting enzyme, and, therefore, on oxidative phosphorylation in colorectal cancer remains to be determined.22505229
Idiopathic Pulmonary FibrosisEpigenetic AlterationsThe role of epigenetic changes in determining the lung phenotype in IPF is unknown.22506007
Idiopathic Pulmonary FibrosisEpigenetic AlterationsOur results provide evidence that epigenetic changes in IPF are widespread and potentially important.22506007
Malignant NeoplasmsEpigenetic AlterationsDNA methyltransferase 1, 3a, and 3b affect DNA methylation, and it is thought that they play an important role in the malignant transformation of various cancers.22520950
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThese data suggest that overexpression of various DNA methyltransferases might represent a critical event responsible for the epigenetic inactivation of multiple tumor suppressor genes, leading to the development of aggressive forms of sporadic breast cancer.22520950
Paget DiseaseEpigenetic AlterationsThe presence of epigenetic and genetic lesions was then correlated to the patient pathology data to determine the potential role of these genes in extramammary Pagets disease etiology and progression.22522847
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsUsing paired tumor and non-tumor lung tissues from 146 individuals from three independent populations we sought to identify common changes in DNA methylation associated with the development of non-small cell lung cancer.22522909
Carcinoma of lungEpigenetic AlterationsKey epigenetic changes associated with lung cancer development: results from dense methylation array profiling.22522909
Carcinoma of lungEpigenetic AlterationsEpigenetic alterations are a common event in lung cancer and their identification can serve to inform on the carcinogenic process and provide clinically relevant biomarkers.22522909
Breast CarcinomaEpigenetic AlterationsOne decade early onset of the breast cancer in Iranian females was reported but the basis of the observed difference has remained unclear and difference in gene silencing by epigenetic processes is suggested.22524805
Diabetes MellitusEpigenetic AlterationsDownregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1.22525256
Pelvic Organ ProlapseEpigenetic AlterationsIncreased microRNA-221/222 and decreased estrogen receptor a in the cervical portion of the uterosacral ligaments from women with pelvic organ prolapse.22527538
Degenerative polyarthritisEpigenetic AlterationsRegulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions.22527881
Liver carcinomaEpigenetic AlterationsMicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells.22528944
Metastasis, Primary malignant neoplasmEpigenetic AlterationsMicroRNA-10b (miR-10b) was recently reported to be dysregulated in some types of cancer and to play a role in invasion and metastasis.22528944
Adenocarcinoma, Neuroendocrine TumorsEpigenetic AlterationsFinally, we also present data supporting the hypothesis that there are differences in miRNA expression between adenocarcinomas and neuroendocrine tumors of the colon.22529906
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsDifferential expression of miRNAs in colorectal cancer: comparison of paired tumor tissue and adjacent normal mucosa using high-throughput sequencing.22529906
Adenocarcinoma of large intestineEpigenetic AlterationsSome of these miRNAs are previously published as potential regulators in colorectal adenocarcinomas such as miR-1, miR-96 and miR-145.22529906
Malignant neoplasm of urinary bladderEpigenetic AlterationsMethylcap-seq reveals novel DNA methylation markers for the diagnosis and recurrence prediction of bladder cancer in a Chinese population.22529986
Malignant Neoplasms, Aggressive behaviorEpigenetic AlterationsDNA methylation affects the aggressiveness of human malignancies.22532250
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsCancers with CpG island methylator phenotype (CIMP), a distinct group with extensive DNA methylation, show characteristic features in several types of tumors.22532250
Carcinoma of lung, NeoplasmsEpigenetic AlterationsCIMP classification using our six-marker panel has implications for personalized medical strategies for lung cancer patients; in particular, DNA methylation inhibitor might be of therapeutic benefit to patients with CIMP-positive tumors.22532250
Adenocarcinoma of lung (disorder)Epigenetic AlterationsIntegrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma.22532250
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe NFATc1 P2 promoter and first intron was found to be hypomethylated and correlated with upregulation of both NFATc1 RNA and protein expression levels in CLL suggesting that an epigenetic mechanism is involved in the constitutive activation of NFAT activity in CLL cells.22534504
Carcinoma, Intraepithelial NeoplasiaEpigenetic AlterationsA microRNA panel to discriminate carcinomas from high-grade intraepithelial neoplasms in colonoscopy biopsy tissue.22535378
Colorectal Cancer PathwayEpigenetic AlterationsThis microRNA panel has considerable clinical value in the early diagnosis and optimal surgical decision-making of colorectal cancer.22535378
NeoplasmsEpigenetic AlterationsThe expression of 723 human microRNAs was measured in laser capture microdissected epithelial tumours from 133 snap-frozen surgical colorectal specimens.22535378
Carcinoma, AdenomaEpigenetic AlterationsOne classifier of 14 microRNAs was identified with a prediction accuracy of 94.1% for discriminating carcinomas from adenomas.22535378
Liver carcinomaEpigenetic AlterationsVCP/p97, down-regulated by microRNA-129-5p, could regulate the progression of hepatocellular carcinoma.22536440
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations in the global DNA methylation status may be associated with an increased risk of some cancer types in humans.22536880
ObesityEpigenetic AlterationsmiRNA and protein expression profiles of visceral adipose tissue reveal miR-141/YWHAG and miR-520e/RAB11A as two potential miRNA/protein target pairs associated with severe obesity.22537031
Experimental Organism Basal Cell CarcinomaEpigenetic AlterationsExpression of microRNAs in basal cell carcinoma.22540308
Malignant NeoplasmsEpigenetic AlterationsPerturbations in the expression profiles of microRNAs (miRNAs) have been reported for a variety of different cancers.22540308
LymphomaEpigenetic AlterationsDetection of these 3 miRNA in plasma of patients can contribute to the clinical diagnosis, treatment and prognosis evaluation of lymphoma.22541087
Childhood Leukemia, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic Alterations[Abnormal expression of microRNA-124 in patients with leukemia or myelodysplastic syndrome and its significance].22541098
Primary malignant neoplasmEpigenetic AlterationsEmerging evidence suggest that microRNAs could serve as non-invasive biomarker for cancer patients.22542158
Pulmonary HypertensionEpigenetic AlterationsErythroid-specific transcriptional changes in PBMCs from pulmonary hypertension patients.22545094
Clinical Coordinator, Colorectal Cancer Pathway, Cell ProliferationEpigenetic AlterationsMicroRNA-143 (miRNA-143) is frequently down-regulated in colorectal cancer (CRC) and may influence CRC cell proliferation, apoptosis and sensitivity to 5-fluorouracil.22549179
Colorectal Cancer PathwayEpigenetic AlterationsDown-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer.22549179
NeoplasmsEpigenetic AlterationsDown-regulation of miRNA-143 was observed in 47 out of 77 (61%) tumours.22549179
Clinical CoordinatorEpigenetic AlterationsOur data indicate that miRNA-143 expression levels serve as an independent prognostic biomarker for CRC in KRAS wild-type patients.22549179
Clinical CoordinatorEpigenetic AlterationsGiven its negative impact on CSS and PFS, miRNA-143 represents a novel prognosticator and a promising drug target for patients with CRC.22549179
ovarian neoplasm, Primary malignant neoplasmEpigenetic AlterationsTogether, the results of this study suggest that low-dose decitabine altered DNA methylation of genes and cancer pathways, restoring sensitivity to carboplatin in patients with heavily pretreated ovarian cancer and resulting in a high RR and prolonged PFS.22549947
ovarian neoplasmEpigenetic AlterationsEpigenetic resensitization to platinum in ovarian cancer.22549947
melanomaEpigenetic AlterationsHistology-specific microRNA alterations in melanoma.22551973
melanomaEpigenetic AlterationsThe lower expression level of six out of seven microRNAs in SSM compared with NM was confirmed by real-time PCR on a subset of cases in the training cohort and validated in an independent cohort of 97 melanoma cases (38 SSM, 59 NM).22551973
Pancreatic carcinomaEpigenetic AlterationsTarget inhibition measured by quantification of histone acetylation was shown at doses of 10 mg/d and was maximal at 40 mg. A partial response was seen in one patient with metastatic acinar pancreatic carcinoma.22553374
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients.22555092
Non-Small Cell Lung CarcinomaEpigenetic AlterationsQuantitative, methylation-specific (HeavyMethyl), real-time polymerase chain reaction assays were used to measure DNA methylation of PITX2 and SHOX2 in bisulfite-converted DNA from formalin-fixed, paraffin-embedded tissues from 474 non-small-cell lung cancer patients.22555092
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDNA methylation of PITX2 and SHOX2 is an independent prognostic biomarker for disease progression in non-small-cell lung cancer patients.22555092
Nasopharyngeal carcinomaEpigenetic AlterationsPrognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis.22560814
Nasopharyngeal carcinoma, Primary malignant neoplasm, NasopharyngitisEpigenetic AlterationsWe retrospectively analysed miRNA expression profiles in 312 paraffin-embedded specimens of nasopharyngeal carcinoma from Sun Yat-sen University Cancer Center (Guangzhou, China) and 18 specimens of non-cancer nasopharyngitis.22560814
TetranitromethaneEpigenetic AlterationsIdentification of patients with the five-miRNA signature might add prognostic value to the TNM staging system and inform treatment decisions for patients at high risk of progression.22560814
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) can be used as prognostic biomarkers in many types of cancer.22560814
Nasopharyngeal carcinomaEpigenetic AlterationsWe aimed to identify miRNAs that were prognostic in patients with nasopharyngeal carcinoma.22560814
Nasopharyngeal carcinoma, NasopharyngitisEpigenetic Alterations41 miRNAs were differentially expressed between nasopharyngeal carcinoma and non-cancer nasopharyngitis tissues.22560814
CataractEpigenetic AlterationsIn addition, several genes that were predicted to be targets of the identified miRNAs have been reported to be involved in lens development or cataract formation.22562507
CataractEpigenetic AlterationsThe differential expression of miRNAs suggests that these miRNAs have potential roles in lens development and/or cataract formation.22562507
CarcinogenesisEpigenetic AlterationsCorrelation of epigenetic aberrance with STAT3 signaling pathway in gastric carcinogenesis.22562532
CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) have been shown to be aberrantly expressed in many human carcinomas.22567743
Endometriosis, Malignant neoplasm of endometriumEpigenetic AlterationsA number of microRNAs (miRNAs), including miR-200 family, are aberrantly expressed in endometriosis and endometrial cancer.22569286
FRAGILE X TREMOR/ATAXIA SYNDROMEEpigenetic AlterationsThese results suggest that sequestration of specific rCGG repeat-binding proteins could lead to aberrant expression of selective miRNAs, which may modulate the pathogenesis of FXTAS by post-transcriptionally regulating the expression of specific mRNAs involved in FXTAS.22570635
CarcinogenesisEpigenetic AlterationsIn carcinogenesis, methylation of DNA promoter regions results in inactivation of tumor-suppressing genes.22571342
Myeloid Leukemia, ChronicEpigenetic AlterationsEpigenetic inactivation of PLCD1 in chronic myeloid leukemia.22576628
Neoplasm MetastasisEpigenetic AlterationsMicroRNAs (miRNAs), which are noncoding RNAs that regulate gene expression, are involved in tumor metastasis.22580051
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-93 inhibits tumor growth and early relapse of human colorectal cancer by affecting genes involved in the cell cycle.22581829
NeoplasmsEpigenetic AlterationsMicroRNA-93 also suppressed tumor growth in null mice.22581829
Clinical CoordinatorEpigenetic AlterationsThis study showed that microRNA-93 can inhibit tumorigenesis and reduce the recurrence of CRC; these findings may have potential clinical applications for predicting the recurrence of CRC.22581829
Clinical CoordinatorEpigenetic AlterationsBecause deregulation of microRNAs is associated with CRC development and recurrence, the expression levels of microRNAs can be a simple and reliable biomarker to detect postoperative early relapse, thereby helping physicians to treat high-risk patients more efficiently.22581829
Primary malignant neoplasmEpigenetic AlterationsmiRNAs are frequently deregulated in cancer and have shown promise as tissue-based markers for cancer classification and prognostication.22583011
HER2-positive carcinoma of breastEpigenetic AlterationsPolymorphism rs4919510:C>G in mature sequence of human microRNA-608 contributes to the risk of HER2-positive breast cancer but not other subtypes.22586447
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe conducted a phase I/II trial of combined epigenetic therapy with azacitidine and entinostat, inhibitors of DNA methylation and histone deacetylation, respectively, in extensively pretreated patients with recurrent metastatic non-small cell lung cancer.22586682
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCombination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer.22586682
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations are strongly associated with the development of cancer.22586682
Liver damage, Hollings Cancer CenterEpigenetic AlterationsThe above findings confirm the accumulation, in the progression of chronic liver damage to HCC, of a ROS-mediated oxidative DNA damage, and suggest that this correlates with induction of telomerase activity and, as a novel finding, with over-expression of miR-92, a microRNA that plays a role in both the apoptotic process and in cellular proliferation pathways.22587342
EndophthalmitisEpigenetic AlterationsImmunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling.22589448
Inflammatory disorderEpigenetic AlterationsRecent discovery of microRNAs and their negative gene regulation have provided new understanding in the pathogenesis of inflammatory diseases.22589448
MIRLET7E geneEpigenetic AlterationsAmong these, four microRNAs (hsa-miR-1, hsa-let-7e, hsa-miR-9, and hsa-miR-182) were known to be associated with the inflammatory signaling pathway.22589448
NeoplasmsEpigenetic AlterationsGene mutation rates (EGFR, KRAS, STK11, TP53), chromosomal instability, regional copy number, and genomewide DNA methylation were significantly different among tumors of the molecular subtypes.22590557
Primary malignant neoplasmEpigenetic AlterationsWhile epigenetic and genetic modifications of DNA have been reported in blood of cancer patients, little is known about modifications of histones on circulating nucleosomes.22593510
Laryngeal Squamous Cell Carcinoma, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are noncoding RNAs involved in posttranscriptional regulation of gene expression in cancer and provide new perspectives on the development of laryngeal squamous cell carcinoma (SCC).22605671
Laryngeal Squamous Cell CarcinomaEpigenetic AlterationsComprehensive expression profiling of microRNAs in laryngeal squamous cell carcinoma.22605671
Stomach CarcinomaEpigenetic AlterationsOverexpression of IFITM1 has clinicopathologic effects on gastric cancer and is regulated by an epigenetic mechanism.22609115
Colorectal Cancer PathwayEpigenetic AlterationsAlthough folate deficiency may contribute to DNA hypomethylation in colorectal cancer, findings on the association between total folate concentration and global DNA methylation have been inconsistent.22609762
Colorectal Cancer PathwayEpigenetic AlterationsBlood and normal mucosa from 112 colorectal cancer patients and 114 healthy people were analyzed for global DNA methylation and folate species distribution using liquid chromatography tandem mass spectrometry.22609762
Primary malignant neoplasmEpigenetic AlterationsThere was no evidence that mucosal global DNA methylation or folate distribution was related to the presence of cancer per se, suggesting that if abnormalities exist, they are confined to individual cells rather than the entire colon.22609762
Malignant NeoplasmsEpigenetic AlterationsEpstein-Barr virus (EBV) is implicated in a range of B-cell malignancies and expresses unique microRNAs (EBV-miRNAs).22609801
Aggressive behaviorEpigenetic AlterationsThese data indicated that DNA methylation alterations at precancerous stages may determine tumor aggressiveness and patient outcome.22610075
Hepatocarcinogenesis, Hepatitis CEpigenetic AlterationsHepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling.22610915
InflammationEpigenetic AlterationsMoreover, microRNA-155 (miR-155) plays an important role in regulating both inflammation and tumorigenesis.22610915
Adenocarcinoma of lung (disorder)Epigenetic AlterationsGenome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression.22613842
NeoplasmsEpigenetic AlterationsWe identified 766 genes showing altered DNA methylation between tumors and non-tumor lung.22613842
Adenocarcinoma of lung (disorder)Epigenetic AlterationsComparison of DNA methylation profiles between lung adenocarcinomas of current and never-smokers showed modest differences, identifying only LGALS4 as significantly hypermethylated and down-regulated in smokers.22613842
NeoplasmsEpigenetic AlterationsUnsupervised analysis of the DNA methylation data identified two tumor subgroups, one of which showed increased DNA methylation and was significantly associated with KRAS mutation and to a lesser extent, with smoking.22613842
Adenocarcinoma of lung (disorder)Epigenetic AlterationsOur analysis lays the groundwork for further molecular studies of lung adenocarcinoma by identifying novel epigenetically deregulated genes potentially involved in lung adenocarcinoma development/progression, and by describing an epigenetic subgroup of lung adenocarcinoma associated with characteristic molecular alterations.22613842
NeoplasmsEpigenetic AlterationsLevels of candidate miRNAs were also quantified in MM tumor samples.22617246
Adenocarcinoma, Squamous cell carcinoma of lungEpigenetic AlterationsmiRNAs expression profiling to distinguish lung squamous-cell carcinoma from adenocarcinoma subtypes.22618509
Admitting diagnosisEpigenetic AlterationsWe identified differential expression profiles of miRNAs in AD and SCC.22618509
NeoplasmsEpigenetic AlterationsA second-generation microRNA-based assay for diagnosing tumor tissue origin.22618571
CarcinogenesisEpigenetic AlterationsMicroRNAs are a family of noncoding, regulatory RNA genes involved in carcinogenesis.22618571
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs that are highly stable in clinical samples and tissue specific serve as ideal biomarkers for cancer diagnosis.22618571
NeoplasmsEpigenetic AlterationsOur first-generation assay identified the tumor of origin based on 48 microRNAs measured on a quantitative real-time polymerase chain reaction platform and differentiated 25 tumor types.22618571
NeoplasmsEpigenetic AlterationsA combination of a binary decision-tree and a k-nearest-neighbor classifier was developed to identify the tumor of origin based on the expression of 64 microRNAs.22618571
Prostate Cancer PathwayEpigenetic AlterationsEpigenetic markers of prostate cancer in plasma circulating DNA.22619380
Primary malignant neoplasmEpigenetic AlterationsEpigenetic differences are a common feature of many diseases, including cancer, and disease-associated changes have even been detected in bodily fluids.22619380
Pancreatic carcinomaEpigenetic AlterationsHowever, the mechanisms by which miRNAs regulate pancreatic cancer (PC) development remain poorly understood.22628193
NeoplasmsEpigenetic AlterationsThe expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.22638884
Malignant NeoplasmsEpigenetic AlterationsOn the base of optimizing experimental design and improving trial protocol, we wanted to know whether the circulating microRNA-21 was dysregulated in the common solid cancers.22638884
MS geneEpigenetic AlterationsIt has also been reported that CD47 expression in multiple sclerosis is regulated by microRNAs.22641236
Cardiovascular DiseasesEpigenetic AlterationsThe data indicate a persisting epigenetic link between early-life maternal diet and/or foetal growth and cardiovascular disease risk in humans.22642564
Primary malignant neoplasmEpigenetic AlterationsThe micro RNA (miRNA) mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase (MMP) inhibitor RECK.22642976
Malignant neoplasm of urinary bladderEpigenetic AlterationsAn evaluation of urinary microRNA reveals a high sensitivity for bladder cancer.22644299
CarcinogenesisEpigenetic AlterationsChanges in microRNA (miR) expression are seen in urothelial carcinogenesis in a phenotype-specific manner.22644299
DICER1 protein, humanEpigenetic AlterationsMicroRNAs are posttranscriptional regulators of messenger RNA synthesis that are intracellularly processed and transferred by the microRNA-regulating machinery consisting of Drosha, Dicer, and Argonaute.22647351
Leukemia, Myelocytic, AcuteEpigenetic AlterationsBy MassARRAY and pyrosequencing, we identified significant DNA methylation differences at the ID4 gene promoter and in the 5 region of members of the SFRP gene family in 62 AML patients compared with healthy controls.22647397
Colorectal Cancer PathwayEpigenetic AlterationsMost work has focused on tissue and cell expression with few reports of circulating miRNAs in colorectal cancer.22648208
Cardiovascular DiseasesEpigenetic AlterationsMicro-RNA-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease.22651868
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsMicro-RNAs were detected by miR profiling in BMCs isolated from healthy volunteers (n = 6) or from patients with myocardial infarction (n = 6), and the results were confirmed by polymerase chain reaction (PCR) in a larger cohort (n = 37).22651868
DICER1 protein, humanEpigenetic AlterationsDicer and Drosha are two key enzymes that are involved in the processing of miRNA production.22658478
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs have been recently identified as important regulators that influence human carcinogenesis, cancer progression, and the interaction between the host and virus.22658643
Bulbo-Spinal Atrophy, X-LinkedEpigenetic AlterationsHere we describe a novel therapeutic approach using the adeno-associated virus (AAV) vector-mediated delivery of a specific miRNA for SBMA.22660636
Neurodegenerative DisordersEpigenetic AlterationsOur results establish the proof of principle that disease-specific miRNA delivery could be useful in neurodegenerative diseases.22660636
Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsForty-one SNPs in 26 microRNA-related genes were genotyped in 1,097 patients with CRC recruited at the University of Texas MD Anderson Cancer Center (Houston, TX).22661538
Clinical CoordinatorEpigenetic AlterationsGenetic polymorphisms in the microRNA pathway may predict prognosis in patients with stage III CRC treated with fluoropyrimidine-based chemotherapy.22661538
SclerodermaEpigenetic AlterationsmicroRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma.22661558
Sample Size CalculationEpigenetic AlterationsClarifying the role of miRNAs in SSc may result in a better understanding of this disease and the development of new therapeutic approaches.22661558
Malignant NeoplasmsEpigenetic AlterationsA germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers.22662244
Disorder of eyeEpigenetic AlterationsThese results provide further evidence that patients with GO do not have a distinct genetic susceptibility to their eye disease and again suggest that environmental and/or epigenetic influences are at play.22663548
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsLower levels of genomic DNA methylation in blood DNA has been associated with risk of different cancers and several cancer risk factors.22665578
MeningiomaEpigenetic AlterationsA microRNA expression signature predicts meningioma recurrence.22674195
MeningiomaEpigenetic AlterationsOur results suggest that the use of miRNA profiling has significant potential as an effective diagnostic and prognostic marker in defining the expression signature of meningiomas and in predicting postsurgical outcomes.22674195
Disease, Primary malignant neoplasmEpigenetic AlterationsThe aberrant expression of microRNAs (miRNAs) is associated with a variety of diseases, including cancer.22674195
MeningiomaEpigenetic AlterationsAfter a two-phase selection and validation process, 14 miRNAs were found to exhibit significantly different expression profiles in meningioma samples compared to normal adjacent tissue (NAT) samples.22674195
Stomach CarcinomaEpigenetic AlterationsTP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep).22675170
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHence, blood-based microarray profiling of microRNA (miR) expression was performed in preoperative serum of 21 non-small cell lung cancer (NSCLC) patients and 11 healthy individuals by microfluid biochips containing 1158 different miRs.22675530
Lung diseases, Non-Small Cell Lung CarcinomaEpigenetic AlterationsTwo out of the 30 most dysregulated miRs were further validated in serum of 97 NSCLC patients, 20 patients with benign lung diseases and 30 healthy individuals by TaqMan MicroRNA Assays.22675530
Colorectal CarcinomaEpigenetic AlterationsWe analysed miRNA expression levels between MDR colorectal carcinoma cell line HCT116/L-OHP cells and their parent cell line HCT116 using a miRNA microarray.22676135
Primary malignant neoplasmEpigenetic AlterationsAccumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression.22677169
Metastasis, Liver carcinomaEpigenetic AlterationsMicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma.22681717
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsmiR-182 is one of the most significantly up-regulated miRNAs in hepatocellular carcinoma (HCC).22681717
OsteosarcomaEpigenetic AlterationsOur findings indicate a crucial impact of deregulated miRNAs with consecutive changes in gene expression in osteosarcomas, which strongly suggests pathogenetic and potentially therapeutic implications.22682620
Transitional cell carcinoma of bladderEpigenetic AlterationsInhibitory effects of microRNA-34a on cell migration and invasion of invasive urothelial bladder carcinoma by targeting Notch1.22684561
Malignant NeoplasmsEpigenetic AlterationsLong noncoding RNAs (lncRNAs) play crucial roles in human cancers.22685290
Chromosomal LossEpigenetic AlterationsTumor-suppressor genes on chromosome X can be inactivated by a single hit, any of the point mutations, chromosomal loss and aberrant DNA methylation.22689052
Malignant neoplasm of gastrointestinal tractEpigenetic AlterationsThese data showed that FHL1 is a methylation-silenced tumor-suppressor gene on chromosome X in gastrointestinal cancers, and that its silencing contributes to the formation of an epigenetic field for cancerization.22689052
NeoplasmsEpigenetic AlterationsDNA methylation is one of the main epigenetic mechanisms and hypermethylation of CpG islands at tumor suppressor genes switches off these genes.22690089
Hollings Cancer CenterEpigenetic AlterationsIn conclusion, we identified 221 novel DNA methylation markers for HCC.22690089
SchizophreniaEpigenetic AlterationsDNA methylation in schizophrenia subjects: gender and MTHFR 677C/T genotype differences.22690662
Verrucous carcinomaEpigenetic AlterationsDifferential expression of microRNAs miR-21, miR-31, miR-203, miR-125a-5p and miR-125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck.22690848
NeoplasmsEpigenetic AlterationsAberrant microRNA (miRNA) expression plays an important role in tumor formation and development.22692639
Malignant neoplasm of thyroidEpigenetic AlterationsIntegration of genetic and epigenetic changes in thyroid cancer will help identify relevant biologic pathways that drive its development.22694820
NeoplasmsEpigenetic AlterationsThe quantitative DNA methylation analysis of the candidate genes showed higher methylation proportion in the primary tumor tissue than that of the matched normal tissue and the differences were significant for the APC, BIN1, BMP6, BRCA1, CST6, ESR-b, P16, PTEN and TIMP3 promoter regions (P<0.05).22695536
Malignant Neoplasms, MetastasisEpigenetic AlterationsInvasion and metastasis are two important hallmarks of malignant tumors caused by complex genetic and epigenetic alterations.22695536
Breast Carcinoma, NeoplasmsEpigenetic AlterationsRelationship between tumor DNA methylation status and patient characteristics in African-American and European-American women with breast cancer.22701537
Breast CarcinomaEpigenetic AlterationsAberrant DNA methylation is critical for development and progression of breast cancer.22701537
Each (qualifier value)Epigenetic AlterationsSignificant differences in the CDH13 methylation status were observed by comparing DNA methylation between AA and EA patients, with more obvious CDH13 methylation differences between the two patient groups in the ER- disease and among young patients (age<50).22701537
Mammary NeoplasmsEpigenetic AlterationsIn conclusion, the DNA methylation status of breast tumors was found to be significantly associated with clinicopathological features and race/ethnicity of the patients.22701537
Aortic Aneurysm, AbdominalEpigenetic AlterationsMicroRNA expression signature in human abdominal aortic aneurysms.22704053
NeoplasmsEpigenetic AlterationsThe relationship between miRNA expression, patient survival and tumor pathological features was also examined.22704449
Malignant neoplasm of urinary bladder, Metastasis, NeoplasmsEpigenetic AlterationsExpression of miRNAs involved in angiogenesis, tumor cell proliferation, tumor suppressor inhibition, epithelial-mesenchymal transition and activation of metastasis in bladder cancer.22704449
Malignant neoplasm of urinary bladder, Metastasis, NeoplasmsEpigenetic AlterationsWe analyzed the expression profile of a group of miRNAs involved in bladder cancer angiogenesis, tumor cell proliferation, tumor suppressor inhibition, epithelial-mesenchymal transition and metastasis activation.22704449
Malignant neoplasm of urinary bladderEpigenetic AlterationsMost miRNAs analyzed are down-regulated in bladder cancer.22704449
melanomaEpigenetic AlterationsAlthough several studies have shown a dysregulation of microRNA (miRNA) expression profiles in cutaneous melanoma, there has been little research on the miRNA machinery itself.22706980
Cutaneous MelanomaEpigenetic AlterationsThe miRNA machinery in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi.22706980
S100A4 protein, humanEpigenetic AlterationsThe results of this study show that the miRNA machinery components argonaute-1, TARBP2 and SND1 are dysregulated in PCMM and CMMM compared to BMN and may play a role in the process of malignant transformation.22706980
Prostate Cancer PathwayEpigenetic AlterationsMicroRNA-23b downregulates peroxiredoxin III in human prostate cancer.22710126
palladiumEpigenetic AlterationsRNA was extracted from the PD effluent after PET, and intra-peritoneal expression of miRNA targets were quantified.22710867
Nasopharyngeal carcinomaEpigenetic AlterationsA single nucleotide polymorphism in microRNA-146a is associated with the risk for nasopharyngeal carcinoma.22711332
Malignant NeoplasmsEpigenetic AlterationsA common GC polymorphism within miRNA-146a precursor region (rs2910164) has been associated with the risk of various cancers despite the underlying mechanism is unclear.22711332
Non-MalignantEpigenetic AlterationsThere is disagreement about the impact of this epigenetic event on protein expression of Cyclin A1 in malignant and non-malignant tissue and there hardly exists any information about possible relationships between Cyclin A1 expression and clinicopathological characteristics in HNSCC.22712549
Colorectal Cancer PathwayEpigenetic AlterationsDown-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer.22716222
Primary malignant neoplasmEpigenetic AlterationsMicroRNA deregulation is a key feature of cancer; however, the molecular mechanisms underlying deregulation are unknown.22716222
DICER1 protein, humanEpigenetic AlterationsDicer is a central enzyme in microRNA processing essential for production of mature microRNAs which, in turn, regulate gene expression post-transcription.22716222
NeoplasmsEpigenetic AlterationsWe hypothesized that alterations in DNA methylation may play a role in the breakage of centromeric repeat sequences in these tumours.22718136
Esophageal carcinoma, X-linked sideroblastic anemiaEpigenetic AlterationsTo explore epigenetic changes in the gene encoding X chromosome-linked inhibitor of apoptosis-associated factor 1 (XAF1) during esophageal carcinogenesis.22719195
Acute myocardial infarctionEpigenetic AlterationsHuman circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction.22719221
SepticemiaEpigenetic AlterationsReceiver operating characteristic curves were generated and the areas under the curve (AUC) for these six miRNAs for predicting sepsis mortality ranged from 0.610 (95%CI: 0.523-0.697) to 0.790 (95%CI: 0.719-0.861).22719975
SepticemiaEpigenetic AlterationsSix serum miRNAs were identified as prognostic predictors for sepsis patients.22719975
Alzheimers DiseaseEpigenetic AlterationsEpigenetic regulation of fatty acid amide hydrolase in Alzheimer disease.22720070
Squamous cell carcinoma of the head and neck, NeoplasmsEpigenetic AlterationsPretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas.22722388
NeoplasmsEpigenetic AlterationsThe goal of this study was to describe the association between pretreatment diet and HNC tumor DNA methylation.22722388
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTumor DNA methylation patterns were assessed using the Illumina Goldengate Methylation Cancer Panel.22722388
MMP8 wt Allele, NeoplasmsEpigenetic AlterationsThese preliminary results suggest that intake of folate, vitamin A and vitamin B12 may be associated with the tumor DNA methylation profile in HNC and enhance tumor suppression.22722388
Primary malignant neoplasm, MMP8 wt Allele, Malignant Head and Neck NeoplasmEpigenetic AlterationsDiet is associated with cancer prognosis, including head and neck cancer (HNC), and has been hypothesized to influence epigenetic state by determining the availability of functional groups involved in the modification of DNA and histone proteins.22722388
Breast Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-9 as potential biomarker for breast cancer local recurrence and tumor estrogen receptor status.22723919
Alzheimers DiseaseEpigenetic AlterationsEpigenetic regulation of BACE1 in Alzheimers disease patients and in transgenic mice.22728099
cervical cancer, Human papilloma virus infectionEpigenetic AlterationsIt has been reported that aberrant DNA methylation can be associated with HPV infection and cervical cancer, and folate is directly involved in DNA methylation via one-carbon metabolism.22729741
Secondary malignant neoplasm of rectumEpigenetic AlterationsMicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis.22735571
Secondary malignant neoplasm of liverEpigenetic AlterationsLiver metastasis tissues showed higher expression of miR-200c (primary CRC = 1.31 vs. liver metastasis = 1.59; p = 0.0014) and miR-141 (primary CRC = 0.14 vs. liver metastasis = 0.17; p = 0.0234) than did primary CRCs, which was significantly associated with hypomethylation of the promoter region of these miRNAs (primary CRC = 61.2% vs. liver metastasis = 46.7%; p < 0.0001).22735571
Rheumatoid Arthritis, Right armEpigenetic AlterationsTherefore, a genome-wide evaluation of DNA methylation loci in fibroblast-like synoviocytes (FLS) isolated from the site of disease in rheumatoid arthritis (RA) was performed.22736089
Right armEpigenetic AlterationsRA and control FLS segregated based on DNA methylation, with 1859 differentially methylated loci.22736089
ArthritisEpigenetic AlterationsDNA methylation of critical genes suggests that RA FLS are imprinted and implicate epigenetic contributions to inflammatory arthritis.22736089
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation levels of vimentin, sFRP1 and HPP1 are significantly higher in colorectal cancer tissue.22736139
Squamous cell carcinoma of oropharynxEpigenetic AlterationsA microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma.22736309
Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7Epigenetic AlterationsThis new miRNA signature was experimentally validated in an independent oropharyngeal SCC cohort.22736309
Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7Epigenetic AlterationsA combined expression signature of these miRNAs was prognostic of oropharyngeal SCC, independent of common clinical features or HPV status.22736309
Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7Epigenetic AlterationsFurthermore, 5 HPV-related miRNAs were identified, which may help to characterize HPV-induced cancers including both oropharyngeal and cervical SCC.22736309
Breast CarcinomaEpigenetic AlterationsDNA methylation of circulating DNA: a marker for monitoring efficacy of neoadjuvant chemotherapy in breast cancer patients.22744714
Medullary carcinoma of thyroidEpigenetic AlterationsMicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary relationships with RET status and outcome.22747440
Malignant Neoplasms, Medullary carcinoma of thyroid, Magnetic-Targeted CarriersEpigenetic AlterationsMicroRNAs (miRNAs) are involved in the pathogenesis of human cancers, including medullary thyroid carcinoma (MTC).22747440
Magnetic-Targeted CarriersEpigenetic AlterationsMTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001).22747440
Medullary carcinoma of thyroid, Magnetic-Targeted CarriersEpigenetic AlterationsmiRNAs are significantly dysregulated in MTC, and this dysregulation is probably an early event in C-cell carcinogenesis.22747440
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDecreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation.22749068
Neoplasms, Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe examined 79 acute myeloid leukemia (AML) patients for DNA methylation of 12 tumor suppressor genes (TSG) and 24 homeobox domain (Hox) genes, and additionally for mutations in DNMT3A gene.22749068
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsIdentification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma.22752059
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe expression levels of the most upregulated miRNA, miR-375 were analyzed by quantitative real-time PCR in human ESCC specimens.22752059
NeoplasmsEpigenetic AlterationsOur results indicate that HDACIs upregulate miRNAs, at least some of which act as tumor suppressors.22752059
Leukemia, Myelocytic, AcuteEpigenetic AlterationsRUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.22753902
Bipolar Disorder, "Alzheimers DiseaseEpigenetic AlterationsEpigenetic modifications in frontal cortex from Alzheimers disease and bipolar disorder patients.22760556
Admitting diagnosisEpigenetic AlterationsAD and BD brains showed several epigenetic similarities, including global DNA hypermethylation, and histone H3 phosphorylation.22760556
Admitting diagnosisEpigenetic AlterationsThese epigenetic modifications involving neuroinflammatory, AA cascade and synaptic markers may contribute to progression in AD and BD and identify new targets for drug development.22760556
Squamous cell carcinoma, NeoplasmsEpigenetic AlterationsHere, we report that miRNA expression profiling provided more precise information when oral squamous cell carcinomas were subcategorized on the basis of clinicopathological parameters (tumor primary site, histological subtype, tumor stage, and HPV16 status).22761427
NeoplasmsEpigenetic AlterationsTransfection of miR-7 and miR-21-mimics reduced the expression of RECK through direct miRNA-mediated regulation, and these miRNAs were inversely correlated with RECK in CAL 27 orthotopic xenograft tumors.22761427
Primary malignant neoplasmEpigenetic AlterationsRecently, the aberrant expressions of miRNAs have become a major focus in cancer research.22761427
NeoplasmsEpigenetic AlterationsFurther investigations demonstrated the regulation of the tumor suppressor gene reversion-inducing cysteine-rich protein with kazal motifs (RECK) by two keratinization-associated miRNAs, miR-7 and miR-21.22761427
Malignant neoplasm of mouth, Aggressive behavior, NeoplasmsEpigenetic AlterationsTaken together, our data show that keratinization is associated with poor prognosis of oral cancer patients and keratinization-associated miRNAs mediate deregulation of RECK which may contribute to the aggressiveness of tumors.22761427
Lynch SyndromeEpigenetic AlterationsRecently, constitutional MLH1 epimutations have been identified in a subset of Lynch syndrome (LS) cases.22763379
Early-onset, NeoplasmsEpigenetic AlterationsMLH1 methylation screening in lymphocyte DNA from patients with early-onset MLH1-methylated LS-associated tumors allows the identification of epimutation carriers.22763379
Primary malignant neoplasmEpigenetic AlterationsEpigenetic events are, along with genetic alteration, important in the development and progression of cancer.22765268
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsGenetic and epigenetic alterations are the two key mechanisms in the development of hepatocellular carcinoma (HCC).22766745
Hyperplasia, Chronic active hepatitisEpigenetic AlterationsThey might serve to increase the diagnostic reproducibility and improve discrimination, especially, between CAH and CA by miRNA expression profiles and between simple and complex hyperplasia through PTEN expression patterns.22766795
Hyperplasia, Endometrial adenocarcinomaEpigenetic AlterationsExpression of miRNAs and PTEN in endometrial specimens ranging from histologically normal to hyperplasia and endometrial adenocarcinoma.22766795
Hyperplasia, Malignant neoplasm of endometriumEpigenetic AlterationsWe measured the expression of six miRNAs (miR-21, 182, 183, 200a, 200c and 205) in 75 formalin-fixed, paraffin-embedded normal, hyperplastic, and malignant endometrial tissue blocks using Taqman-based real-time PCR assays.22766795
Endometrial Carcinoma, Hyperplasia, She Chinese, Chronic active hepatitisEpigenetic AlterationsExpression of five miRNAs (miR-182, 183, 200a, 200c and 205) was significantly higher in endometrial carcinoma (CA) when compared with complex atypical hyperplasia (CAH), simple hyperplasia (SH) and normal endometrial tissue (P<0.05, respectively).22766795
Endometrial HyperplasiaEpigenetic AlterationsConsidering the likelihood ratio and number of parameters, the composite panel of six miRNAs was the best marker, revealing a sensitivity of 91% and a specificity of 94% in differentiating endometrial CA from endometrial hyperplasia or normal endometrium while the individual miRNAs exhibited 64-77% sensitivity and 66-91% specificity.22766795
Chronic active hepatitisEpigenetic AlterationsInterestingly, in distinguishing endometrial CA from CAH, the composite panel of four miRNAs (miR-182, 183, 200a, 200c) was the best marker, producing 95% sensitivity and 91% specificity.22766795
Endometrial HyperplasiaEpigenetic AlterationsAberrant expression of miRNAs and loss of PTEN expression are common in endometrial hyperplasia and CA.22766795
Neoplasms, Renal Cell Carcinoma PathwayEpigenetic AlterationsTumor suppressive microRNA-138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma.22766839
Renal Cell Carcinoma Pathway, Primary malignant neoplasm, Refractory Cytopenia of ChildhoodEpigenetic AlterationsPreviously, our miRNA expression signature of renal cell carcinoma (RCC) revealed that microRNA-138 (miR-138) was significantly reduced in cancer cells.22766839
Malignant NeoplasmsEpigenetic AlterationsMany studies have recently suggested that microRNAs (miRNAs) contribute to the development of various types of human cancers as well as to their invasive and metastatic capacities.22766839
Primary malignant neoplasmEpigenetic AlterationsCancer cells exhibit two types of DNA methylation alterations: global DNA hypomethylation and site-specific CpG island promoter hypermethylation.22766991
Squamous cell carcinoma of esophagusEpigenetic AlterationsSelected gene promoter hypermethylation in normal esophageal mucosae has attracted attention as a surrogate marker for the epigenetic field defect induced by smoking and/or drinking in esophageal squamous cell carcinoma (ESCC).22766991
NeoplasmsEpigenetic AlterationsThe microRNA cluster C19MC is deregulated in parathyroid tumours.22767050
Parathyroid Gland AdenocarcinomaEpigenetic AlterationsA subset of over-expressed microRNAs (miRNAs) identified in parathyroid carcinomas (Ca) compared to normal glands belongs to C19MC, a cluster on chromosome 19q13.4 involved in stem cell biology and tumourigenesis.22767050
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsIn the last decade, studies in hepatocellular carcinoma (HCC) demonstrate dysregulation of miRNAs expression.22767438
Malignant NeoplasmsEpigenetic AlterationsDNA methylation changes are common and relatively stable in various types of cancers, and may be used as diagnostic or prognostic biomarkers.22768131
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe performed DNA methylation profiling of samples from 48 patients with stage I NSCLC and 18 matching cancer-free lung samples using microarrays that cover the promoter regions of more than 14,500 genes.22768131
NeoplasmsEpigenetic AlterationsAltered DNA methylation of tumor suppressor gene promoters plays a role in human carcinogenesis and DNA methyltransferases (DNMTs) are responsible for it.22768205
Metastasis, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs regulate gene expression at the post-transcriptional level and play important roles in cancer development, progression, and metastasis.22772712
Malignant Neoplasms, AstrocytomaEpigenetic AlterationsIDH1 mutations showed wide regulation of angiogenesis and genome-wide change of histone and DNA methylation, which were not suppressed as the malignancy level progressed, suggesting an early role of IDH1 mutations in astrocytoma tumorigenesis.22772731
Breast Carcinoma, MetastasisEpigenetic AlterationsDetection of methylated CEBPd genomic DNA may have utility as an epigenetic biomarker of primary breast carcinomas at increased risk of relapse and metastasis.22782348
GliomaEpigenetic AlterationsAlterations of DNA methylation play an important role in gliomas.22787434
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsThe risk of colorectal cancer (CRC) may be influenced by aberrant DNA methylation and altered nucleotide synthesis and repair, possibly caused by impaired dietary folate intake as well as by polymorphic variants in one-carbon metabolism genes.22794911
NeoplasmsEpigenetic AlterationsThese findings suggest that the detection of microRNA-21 in serum might serve as a new tumor biomarker in diagnosis and assessment of prognosis of ESCCs.22799367
Depressed moodEpigenetic AlterationsWe detected intensive DNA methylation within a recently described, functional important region of the ACE gene promoter including hypermethylation in depressed patients (p = 0.008) and a significant inverse correlation between the ACE serum concentration and ACE promoter methylation frequency in the total sample (p = 0.02).22808171
Cardiovascular DiseasesEpigenetic AlterationsThe results of the present study suggest that aberrations in ACE promoter DNA methylation may be an underlying cause of MD and probably a common pathogenic factor for the bi-directional relationship between MD and cardiovascular disorders.22808171
Prostate Cancer PathwayEpigenetic AlterationsAberrant DNA methylation plays a role in prostate cancer progression.22810147
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAltered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance.22810507
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsCirculating miRNA is a novel marker for head and neck squamous cell carcinoma.22811001
Breast Carcinoma, Malignant Neoplasms, Carcinoma of lung, Prostate Cancer Pathway, Malignant neoplasm of urinary bladder, Colorectal Cancer PathwayEpigenetic AlterationsAltered microRNAs (miRNAs) expression has been found in many cancers, including lung cancer, breast cancer, prostate cancer, bladder cancer and colorectal cancer.22811001
Malignant NeoplasmsEpigenetic AlterationsMany recent studies have demonstrated that aberrant plasma miRNAs were also found in various types of cancers.22811001
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsWe previously identified an miRNA signature for type 2 diabetes in the general population.22813605
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsIn subjects with subsequent myocardial infarction, differential co-expression patterns of circulating miRNAs occur around endothelium-enriched miR-126, with platelets being a major contributor to this miRNA signature.22813605
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsOne cluster included all miRNAs associated with the risk of future myocardial infarction.22813605
Prostate carcinomaEpigenetic AlterationsIdentification of ZNF217, hnRNP-K, VEGF-A and IPO7 as targets for microRNAs that are downregulated in prostate carcinoma.22815235
CHOANAL ATRESIA, POSTERIOR, Primary malignant neoplasmEpigenetic AlterationsWe previously detected several miRNAs, for example, miR-24 and miR-22, as significantly downregulated in PCa (Szczyrba et al., Mol Cancer Res 2010;8:529-38).22815235
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsAdditionally, for two genes that are deregulated in PCa (heterogeneous nuclear ribonucleoprotein K, hnRNP-K, and vascular endothelial growth factor A, VEGF-A), we identified two regulatory miRNAs, miR-205 and miR-29b.22815235
Multiple Myeloma, Malignant neoplasm of testisEpigenetic AlterationsEpigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity.22816680
Malignant neoplasm of testisEpigenetic AlterationsEpigenetic induction of an adaptive immune response to cancer testis antigens is safe and feasible in MM patients undergoing SCT.22816680
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer.22818121
Non-Small Cell Lung CarcinomaEpigenetic AlterationsFive SNPs found in pre-miRNAs (rs11614913/miR-196a2, rs2910164/miR-146a, rs6505162/miR-423, rs2289030/miR-492, and rs895819/miR-27a) and 2 SNPs found in pri-miRNAs (rs7372209/miR-26a-1 and rs213210/miR-219-1) were genotyped in 388 patients with NSCLC.22818121
NeoplasmsEpigenetic AlterationsSince epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in the development of LC.22818553
Stomach CarcinomaEpigenetic AlterationsThese findings demonstrated that decreased RASAL1 expression is a characteristic of gastric cancer and regulated by epigenetic mechanisms.22825043
Adenocarcinoma of duodenumEpigenetic AlterationsThe purpose was to identify possible subsets of duodenal adenocarcinomas based on microsatellite instability (MSI), DNA methylation, mutations in the KRAS and BRAF genes, clinicopathologic features, and prognosis.22825585
Adenocarcinoma of duodenumEpigenetic AlterationsLittle information is available on genetic and epigenetic changes in duodenal adenocarcinomas.22825585
Admitting diagnosisEpigenetic AlterationsFurthermore, we found that SORL1 promoter DNA methylation might act as one of the mechanisms responsible for the differences in expression observed between blood and brain for both healthy elderly and AD patients groups.22836009
Chronic Kidney DiseasesEpigenetic AlterationsWe observed an alteration of the platelet messenger RNA (mRNA) and microRNA transcriptome in CKD patients.22836280
UremiaEpigenetic AlterationsReduced in platelets of uraemic patients, phosphatidylcholine transfer protein (PCTP) and WD repeat-containing protein 1 (WDR1) were found to be regulated by microRNAs, the latter of which involving hsa-miR-19b, a microRNA increased in platelets of uraemic patients and involved in platelet reactivity.22836280
Uremia, Chronic Kidney DiseasesEpigenetic AlterationsThese results suggest that an alteration of microRNA-based mRNA regulatory mechanisms may underlie the platelet response to uremia and entail the development of platelet-related complications in CKD.22836280
MesotheliomaEpigenetic AlterationsOur goal is to identify DNA methylation of these three candidate genes in two peritoneal mesothelioma cases.22836805
Malignant Pleural MesotheliomaEpigenetic AlterationsRecent research on the pathogenesis of malignant pleural mesothelioma has indicated that both epigenetic and genetic alterations contribute to tumorigenesis.22836805
MesotheliomaEpigenetic AlterationsHere, we hypothesize that peritoneal mesothelioma also has an epigenetic alteration in the same genes (Kazal-type serine peptidase inhibitor domain 1 (KAZALD1), transmembrane protein 30B (TMEM30B), and mitogen-activated protein kinase 13 (MAPK13)).22836805
NeoplasmsEpigenetic AlterationsThe role of microRNAs (miRNAs) in tumor biology might pinpoint an alteration in expression of miRNAs as new diagnostic/prognostic biomarkers.22836856
SERPINB3 wt AlleleEpigenetic AlterationsThese results suggest that regulation of podoplanin is not simple, but in the majority of OSCC cell lines, its expression is positively and negatively regulated by TGF-b receptor/Smad signaling pathway and epigenetic mechanism leading to squamous differentiation, respectively.22840788
Nasopharyngeal carcinomaEpigenetic AlterationsExpression of miRNA-146a in nasopharyngeal carcinoma is upregulated by Epstein-Barr virus latent membrane protein 1.22843060
NasopharyngitisEpigenetic AlterationsThe miRNA-146a levels in NPC were significantly higher than that in chronic nasopharyngitis (p<0.01), and were higher in CNE1-GL cells than those in CNE1 cells (p<0.01).22843060
Nasopharyngeal carcinomaEpigenetic AlterationsOverexpression of Epstein-Barr virus-encoded microRNA-BART7 in undifferentiated nasopharyngeal carcinoma.22843893
SepticemiaEpigenetic AlterationsCorticosteroid resistance in sepsis is influenced by microRNA-124--induced downregulation of glucocorticoid receptor-a.22846781
TSC22D3 geneEpigenetic AlterationsFurthermore, a glucocorticoid-induced three-fold upregulation of microRNA-124 was found.22846781
Malignant neoplasm of urinary bladderEpigenetic AlterationsGenetic variants in miRNAs predict bladder cancer risk and recurrence.22846912
CarcinogenesisEpigenetic AlterationsmiRNAs play important roles in numerous cellular processes, including development, proliferation, apoptosis, and carcinogenesis.22846912
Secondary malignant neoplasm of female breastEpigenetic AlterationsMicroRNA-10b targets E-cadherin and modulates breast cancer metastasis.22847191
Breast Carcinoma, MetastasisEpigenetic AlterationsRecent studies have suggested that microRNA-10b (miR-10b) acts as a promoter of metastasis in breast cancer, although the underlying mechanism remains largely unknown.22847191
Neoplasms, Neoplasm MetastasisEpigenetic AlterationsThe tumor suppressor gene p53 has been implicated in the regulation of epithelial-mesenchymal transition (EMT) and tumor metastasis by regulating microRNA (miRNA) expression.22847613
Hepatitis B, Liver carcinomaEpigenetic AlterationsAssociation of polymorphism in pri-microRNAs-371-372-373 with the occurrence of hepatocellular carcinoma in hepatitis B virus infected patients.22848681
Inflammatory disorder, MS geneEpigenetic AlterationsSince miR-155 has recently been demonstrated to up-regulate IFN-g, this microRNA might represent a novel therapeutic target in HAM/TSP, as recently demonstrated in multiple sclerosis, another neuroinflammatory disease.22848768
Pancreatic carcinomaEpigenetic AlterationsExpression of microRNAs in patients with pancreatic cancer and its prognostic significance.22850622
Adenocarcinoma of pancreasEpigenetic AlterationsInvestigation of expression profile of well-established microRNAs in pancreatic adenocarcinoma, and its correlation with clinicopathological factors.22850622
Prostate Cancer Pathway, InflammationEpigenetic AlterationsGenetic factors regulating inflammation and DNA methylation associated with prostate cancer.22850906
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe GNMT T allele may influence PCa risk by affecting DNA methylation and prostate gene expression.22850906
Stomach CarcinomaEpigenetic Alterations[Expression of microRNA-183 in stage II ( gastric cancer and its association with Ezrin protein].22851079
Pancreatic carcinoma, Primary malignant neoplasmEpigenetic AlterationsPrognostic microRNAs in cancer tissue from patients operated for pancreatic cancer--five microRNAs in a prognostic index.22851141
Primary malignant neoplasmEpigenetic AlterationsMiRNAs were purified from formalin-fixed paraffin embedded (FFPE) cancer tissue from 225 patients operated for PC.22851141
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsTumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer.22854542
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThis study seeks to identify novel miRNA-regulated molecular pathways in prostate cancer (PCa).22854542
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe miRNA expression signature in clinical specimens of PCa showed that 56 miRNAs were significantly downregulated in PCa compared with non-PCa tissues.22854542
Metastasis, NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs) have key roles in human tumorigenesis, tumor progression and metastasis.22854542
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsmiRNAs are aberrantly expressed in many human cancers and can function as tumor suppressors or oncogenes that target many cancer-related genes.22854542
Carcinogenesis, NeoplasmsEpigenetic AlterationsIdentification and categorization of the molecular pathways regulated by tumor suppressive miRNAs could provide new information about the molecular mechanisms of PCa tumorigenesis.22854542
Papillary thyroid carcinoma, F9 geneEpigenetic AlterationsCorrelation between clinicopathogenetic features and the expression of specific miRNAs is unclear in papillary thyroid carcinoma (PTC).22855362
Stomach CarcinomaEpigenetic AlterationsPlasma microRNAs, miR-223, miR-21 and miR-218, as novel potential biomarkers for gastric cancer detection.22860003
Malignant neoplasm of urinary bladderEpigenetic AlterationsPlasma microRNA profiles for bladder cancer detection.22863868
Malignant neoplasm of urinary bladderEpigenetic AlterationsPlasma miRNA was isolated from 20 patients with bladder cancer and 18 noncancerous controls.22863868
Prostate carcinomaEpigenetic AlterationsDo microRNA 96, 145 and 221 expressions really aid in the prognosis of prostate carcinoma?22864280
Clinical CoordinatorEpigenetic AlterationsGenetic and epigenetic alterations of APC may therefore be associated with dietary and lifestyle risk factors for CRC.22864938
Helicobacter pyloriEpigenetic AlterationsHelicobacter pylori decreases p27 expression through the delta opioid receptor-mediated inhibition of histone acetylation within the p27 promoter.22867947
Clinical CoordinatorEpigenetic AlterationsMiRNAs are non-protein-coding RNAs regulating gene expression that play a role in CRC development.22868372
Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsLevels of 380 miRNAs were determined using microfluidic array technology (Applied Biosystems) in a "training" set of 30 CRC patients from whom cancer and adjacent normal tissue were collected.22868372
Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsThe 4 most dysregulated miRNAs (P < 0.05, false discovery rate (FDR): 10%) were then validated in a second blinded "test" set of 16 CRC patients from whom cancer and normal adjacent tissue had been collected.22868372
Clinical CoordinatorEpigenetic AlterationsValidated tissue miRNAs were then evaluated in a plasma "test" set consisting of 30 CRC patients and 30 individuals without CRC.22868372
Clinical CoordinatorEpigenetic AlterationsThe most dysregulated tissue miRNAs were then validated in an independent new plasma test set consisting of 20 CRC patients with 20 age-, -, and race-matched subjects without CRC.22868372
Clinical CoordinatorEpigenetic AlterationsThe 2 most upregulated (miR-31; miR-135b) and most downregulated (miR-1; miR-133a) miRNAs identified CRC in our "test" set with 100% sensitivity and 80% specificity.22868372
Clinical CoordinatorEpigenetic AlterationsPlasma miRNAs provide reliable and noninvasive markers for CRC.22868372
DiseaseEpigenetic AlterationsSerum microRNAs may be useful biomarkers for diagnosing human diseases.22868808
NeoplasmsEpigenetic AlterationsAn expanded patient cohort (tumor n=149, matched normal n=30) also showed significant MIR-205 DNA methylation in tumors compared with normal, and MIR-205 hypermethylation is significantly associated with biochemical recurrence (hazard ratio=2.005, 95% confidence interval (1.109, 3.625), P=0.02), in patients with low preoperative prostate specific antigen.22869146
Prostate Cancer PathwayEpigenetic AlterationsEpigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer.22869146
CarcinogenesisEpigenetic AlterationsDeregulation of microRNA (miRNA) expression can have a critical role in carcinogenesis.22869146
Prostate Cancer PathwayEpigenetic AlterationsHere we show in prostate cancer that miRNA-205 (miR-205) transcription is commonly repressed and the MIR-205 locus is hypermethylated.22869146
Glioblastoma MultiformeEpigenetic AlterationsA novel volume-age-KPS (VAK) glioblastoma classification identifies a prognostic cognate microRNA-gene signature.22870228
SCGB3A1 wt AlleleEpigenetic AlterationsMethylation of HIN-1 promoter is a novel epigenetic biomarker associated with poor outcomes in OCCA patients.22871047
Malignant Neoplasms, Carcinogenesis, CHOANAL ATRESIA, POSTERIOR, Prostate Cancer PathwayEpigenetic AlterationsDNA methylation plays an important role in carcinogenesis and is being recognized as a promising diagnostic and prognostic biomarker for a variety of malignancies including Prostate cancer (PCa).22874102
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsSubsequently, we have quantified KLK6 and KLK10 DNA methylation levels in two independent cohorts of PCa patients operated by radical prostatectomy between 2007-2011 (Cohort I, n = 150) and 1998-2001 (Cohort II, n = 124).22874102
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe results suggest that KLK6 and KLK10 DNA methylation distinguishes organ confined from locally invasive PCa and may have prognostic value.22874102
Inflammatory disorder, PeriodontitisEpigenetic AlterationsThe role of epigenetic regulation in inflammatory diseases such as periodontitis is poorly known.22875665
Malignant tumor of colon, Colorectal Cancer PathwayEpigenetic AlterationsIdentification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry.22878509
Adenocarcinoma of ampulla of Vater, Adenocarcinoma of pancreasEpigenetic AlterationsMicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma.22878649
Adenocarcinoma of ampulla of Vater, Adenocarcinoma of pancreasEpigenetic AlterationsThe expression of 664 microRNAs in tissue from 170 pancreatic adenocarcinomas and 107 ampullary adenocarcinomas were analyzed using a commercial microRNA assay.22878649
Adenocarcinoma of ampulla of VaterEpigenetic AlterationsMicroRNA profiles of pancreatic and ampullary adenocarcinomas were correlated (0.990).22878649
Pancreatic carcinoma, Adenocarcinoma of pancreasEpigenetic AlterationsMicroRNA expression profiles for pancreatic cancer described in the literature were consistent with our findings, and the microRNA profile for pancreatic adenocarcinoma (miR-196b-miR-217) was validated.22878649
Adenocarcinoma of ampulla of VaterEpigenetic AlterationsWe also identified microRNA profiles to subclassify ampullary adenocarcinomas into pancreatobiliary or intestinal type.22878649
Pancreatitis, Chronic, Adenocarcinoma of ampulla of VaterEpigenetic AlterationsA diagnostic 19 microRNA classifier was constructed which without micro-dissection could discriminate pancreatic and ampullary adenocarcinomas from chronic pancreatitis and normal pancreas with high sensitivity and accuracy.22878649
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs have potential as diagnostic cancer biomarkers.22878649
Pancreatic carcinomaEpigenetic AlterationsIn all, 43 microRNAs had higher and 41 microRNAs reduced expression in pancreatic cancer compared with normal pancreas.22878649
Pancreatitis, Chronic, Adenocarcinoma of pancreasEpigenetic AlterationsIn all, 32 microRNAs were differently expressed in pancreatic adenocarcinoma compared with chronic pancreatitis (17 higher; 15 reduced).22878649
Fibrosis Assessment, Aortic Valve StenosisEpigenetic AlterationsMyocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients.22882958
Degenerative polyarthritisEpigenetic AlterationsAmongst these 7 human miRNAs, 1 was up-regulated in OA chondrocytes (hsa-miR-483-5p) and 6 were up-regulated in normal chondrocytes (hsa-miR-149*, hsa-miR-582-3p, hsa-miR-1227, hsa-miR-634, hsa-miR-576-5p and hsa-miR-641).22883423
Degenerative polyarthritisEpigenetic AlterationsWe have identified 7 miRNAs differentially expressed in OA and normal chondrocytes.22883423
Non-Small Cell Lung CarcinomaEpigenetic AlterationsGlutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC.22884253
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsQuantitative real-time PCR was used to measure mRNA expression and DNA methylation of GST-PI in paired tumor (T) and non-tumor (N) lung tissue of 91 NSCLC patients.22884253
Tetranitromethane, NeoplasmsEpigenetic AlterationsThe median GST-PI methylation was not significantly different between T and N. No associations were seen between the mRNA expression or DNA methylation levels and clinical or histopathologic parameters such as gender, age, TNM stage, tumor histology and grading.22884253
Aggressive behavior, Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsHigh levels of GST-PI DNA methylation in tumor tissue of NSCLC patients have a potential as a biomarker identifying subpopulations with a more aggressive tumor biology.22884253
Colorectal Cancer PathwayEpigenetic AlterationsDownregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer.22885837
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsRecently, microRNA-124 (miR-124) has been demonstrated as a potential tumor suppressor in several types of cancers.22885837
NeoplasmsEpigenetic AlterationsThe results showed that miRNA expression (increased or decreased) in the paired benign and tumor tissue was consistent between the two methods in all cases.22886225
Primary malignant neoplasmEpigenetic AlterationsmiRNA profile in rectal cancer showed unique characteristics, and identified a series of new, aberrantly expressed miRNAs.22886225
Primary malignant neoplasmEpigenetic Alterations[Identification of aberrantly expressed miRNAs in rectal cancer].22886225
Primary malignant neoplasmEpigenetic AlterationsTo identify aberrantly expressed miRNAs in rectal cancer.22886225
Malignant Neoplasms, Colorectal Cancer PathwayEpigenetic AlterationsAll 6 paired rectal cancers were classified pathology stage C or D. Eighty-eight miRNAs were up-regulated and 46 miRNAs have been reported in colorectal cancer; 40 miRNAs were down-regulated in rectal cancers and 15 miRNAs have been reported in colorectal cancer.22886225
Prostate Cancer Pathway, Hormone refractory prostate cancerEpigenetic AlterationsWe demonstrated that serum samples from patients of low risk, localized prostate cancer and metastatic CRPC patients exhibit distinct circulating miRNA signatures.22887127
Prostate Cancer PathwayEpigenetic AlterationsExpression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer.22887127
Prostate Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsIn the search for improved minimally invasive methods to follow cancer pathogenesis, the correlation of disease status with the expression patterns of circulating miRNAs may indicate the potential importance of circulating miRNAs as prognostic markers for prostate cancer progression.22887127
Atypical Reparative Cell, CRYAA geneEpigenetic AlterationsTo assess the potential contribution of epigenetic regulation of CRYAA genes relevant to ARC pathogenesis, we evaluated DNA methylation, a tissue-specific genetic modulation that affects gene expression.22889833
CRYAA gene, CataractEpigenetic AlterationsThe evidence presented suggests that CRYAA undergoes epigenetic repression in the lens epithelia in age-related nuclear cataract.22889833
Cardiac ArrestEpigenetic AlterationsCirculating microRNAs after cardiac arrest.22890253
Acute Coronary Syndrome, Cardiac ArrestEpigenetic AlterationsWhile the potential of circulating microRNAs as biomarkers of acute coronary syndromes is an active field of investigation, it is unknown whether microRNAs are associated with outcome in cardiac arrest patients.22890253
Brain Injuries, Cardiac ArrestEpigenetic AlterationsIn vitro experiments showed that both miR-122 and miR-21 are produced by neuronal cells, indicating that the elevation of circulating levels of these microRNAs after cardiac arrest may reflect brain damage.22890253
Cardiac ArrestEpigenetic AlterationsAs compared to neuron-specific enolase, circulating microRNAs are modest but significant predictors of neurological outcome and mortality in this small group of patients with cardiac arrest.22890253
melanoma, NeoplasmsEpigenetic AlterationsIn situ measurement of miR-205 in malignant melanoma tissue supports its role as a tumor suppressor microRNA.22890556
NeoplasmsEpigenetic AlterationsWe utilized quantitative in situ hybridization (qISH) to evaluate the tumor suppressing properties of miRNA, miR-205 in a population of human tumors.22890556
melanoma, NeoplasmsEpigenetic AlterationsLow levels of melanoma cell miR-205 expression as quantified by ISH show worse outcome, supporting the role of miR-205 as a tumor suppressor miRNA.22890556
melanoma, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsOncogenic and tumor suppressing microRNAs (miRNAs) have emerged as key regulators of gene expression in many types of cancer including melanoma.22890556
Glioblastoma MultiformeEpigenetic AlterationsPlasma MicroRNA-21 concentration may be a useful biomarker in glioblastoma patients.22891879
Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-21 was shown to induce glioblastoma growth.22891879
Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05).22891879
Glioblastoma MultiformeEpigenetic AlterationsCirculating microRNA-21 might be a useful biomarker in glioblastoma.22891879
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs are proposed as plasma biomarkers in cancer.22891879
NeoplasmsEpigenetic AlterationsHowever, Pearson analysis showed no statistical correlation in the relative miRNAs expression between plasma and esophageal tissues, which suggested different origins of circulating miRNAs distinct from tumor cell miRNAs.22891887
Progranulins, Frontotemporal dementiaEpigenetic AlterationsTMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.22895706
Progranulins, Depression, CTCAE, TMEM106B gene, Frontotemporal dementiaEpigenetic AlterationsThus, TMEM106B is an FTLD-TDP risk gene, with microRNA-132/212 depression as an event which can lead to aberrant overexpression of TMEM106B, which in turn alters progranulin pathways.22895706
Breast Carcinoma, NeoplasmsEpigenetic AlterationsReal-time polymerase chain reaction was used to profile microRNA (miRNA) in tumor tissue from 50 breast cancer patients using non-tumor breast tissue from each patient as a control.22898264
Breast CarcinomaEpigenetic AlterationsWe have focussed on three miRNA; miR-21, miR-125b and miR-191, all of which have been implicated in breast cancer with either proven or predicted target genes involved in critical cancer-associated cellular pathways.22898264
Breast CarcinomaEpigenetic AlterationsThese observations, although a proof of principle finding at this time, show that a combined expression profile of two miRNA (miR-125b/miR-191 and miR-21/miR-191) can discriminate between breast cancer and non-tumor tissue with high specificity and sensitivity.22898264
Inflammatory Bowel DiseasesEpigenetic AlterationsMicroRNA expression patterns in indeterminate inflammatory bowel disease.22899284
Ulcerative Colitis, Colitis, Crohn Disease-like ReactionEpigenetic AlterationsAmong the 16 indeterminate colitis patients, 15 showed ulcerative colitis-like and one Crohns disease-like microRNA pattern.22899284
Ulcerative Colitis, Crohn Disease, ColitisEpigenetic AlterationsMicroRNA expression patterns in indeterminate colitis are far more similar to those of ulcerative colitis than Crohns disease.22899284
Colitis, UlcerEpigenetic AlterationsMicroRNA expression patterns of indeterminate colitis provide molecular evidence indicating that most cases are probably ulcerative colitis-similar to the data from long-term clinical follow-up studies.22899284
Inflammatory Bowel DiseasesEpigenetic AlterationsValidation of microRNA results by additional long-term outcome data is needed, but the data presented show promise for improved classification of indeterminate inflammatory bowel disease.22899284
Ulcerative Colitis, Crohn Disease, ColitisEpigenetic AlterationsThe average expression level of all five microRNAs was statistically different between indeterminate colitis and Crohns disease groups (P<0.05); no significant difference was present between indeterminate and ulcerative colitis groups.22899284
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-126 inhibits tumor cell growth and its expression level correlates with poor survival in non-small cell lung cancer patients.22900072
NeoplasmsEpigenetic AlterationsIt is controversial whether microRNA-126 is a tumor suppressive or oncogenic miRNA.22900072
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMore experiments are needed to determine whether microRNA-126 is associated with non-small cell lung cancer risk and prognosis.22900072
NeoplasmsEpigenetic AlterationsWe analyzed the associations of the microRNA-126 expression between genetic variants within microRNA-126 and clinical information including smoking status, sex, age, and histological type and the tumor stage.22900072
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsOver-expression of microRNA-126 in NSCLC cell lines decreased cell proliferation in vitro and tumor growth in the nude mouse xenograft model.22900072
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsThe expression level of microRNA-126 was decreased in NSCLC lines and tumor tissues.22900072
Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur data indicate that microRNA-126 is a tumor-suppressor gene in NSCLC and low microRNA-126 expression is a unfavorable prognostic factor in NSCLC patients.22900072
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsTherefore, further research is needed to explore the tumor suppressive functions of microRNA-126 in NSCLC.22900072
Tuberculosis, PulmonaryEpigenetic AlterationsAltered microRNA signatures in sputum of patients with active pulmonary tuberculosis.22900099
TuberculosisEpigenetic AlterationsWe found that 95 miRNAs were differentially expressed between tuberculosis group and controls.22900099
TuberculosisEpigenetic AlterationsMore miRNAs (52 out of 95 miRNAs) were underexpressed than overexpressed during tuberculosis infection.22900099
Tuberculosis, PulmonaryEpigenetic AlterationsFor the first time, differential expression of miRNAs in sputum was found in active pulmonary tuberculosis.22900099
Neoplasms, Leukemia, Myelocytic, AcuteEpigenetic AlterationsTaken together, miR-370 may function as a tumor suppressor by targeting FoxM1, and the epigenetic silence of miR-370 thus leads to derepression of FoxM1 expression and consequently contributes to AML development and progression.22900969
Malignant Neoplasms, Leukemia, Myelocytic, AcuteEpigenetic AlterationsRecent evidence has accumulated that MicroRNA (miRNA) dysregulation occurs in the majority of human malignancies including acute myeloid leukemia (AML) and may contribute to onco-/leukemo-genesis.22900969
Neoplasms, Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemia.22900969
Metastasis, NeoplasmsEpigenetic AlterationsThe discovery that microRNA (miRNA) regulates metastasis provide a principal molecular basis for tumor heterogeneity.22901144
Secondary malignant neoplasm of female breast, NeoplasmsEpigenetic AlterationsIt is necessary to discover the mechanism of breast cancer metastasis in relation to the fact that there is a differential distribution of crucial microRNA in tumors from centers to edges.22901144
Breast CarcinomaEpigenetic AlterationsOur data suggest that miR-20a and miR-20b are differentially distributed in breast cancer, while VEGF-A and HIF-1alpha mRNA had coincident distributions, and VEGF-A and HIF-1alpha proteins had uneven and opposing distributions to the miRNAs.22901144
Colorectal Cancer PathwayEpigenetic AlterationsGenome-wide analysis of aberrant DNA methylation for identification of potential biomarkers in colorectal cancer patients.22901147
Malignant Neoplasms, Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic modifications, such DNA methylation, have also been implicated in many cancers but have yet to be examined in the East Asian population of colorectal cancer patients.22901147
Colorectal Cancer PathwayEpigenetic AlterationsThe deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer.22903020
Colorectal Cancer PathwayEpigenetic AlterationsWe are interested in revealing the relationship between deregulated miRNAs and deoxycholic acid in colorectal cancer development.22903020
Amyotrophic Lateral SclerosisEpigenetic AlterationsA miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis.22903028
Neurodegenerative DisordersEpigenetic AlterationsIn addition, misregulation of microRNAs contributes to some mental disorders and neurodegeneration diseases.22903028
DiseaseEpigenetic AlterationsMicroRNAs, a class of noncoding RNAs, play roles in human diseases.22903258
Rheumatoid ArthritisEpigenetic AlterationsOverexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation.22903258
Malignant neoplasm of endometriumEpigenetic AlterationsThe different expression of miRNAs could modulate the expression of angiogenic and antiangiogenic factors, which may play an important role in the pathogenesis of endometrial cancer.22904162
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNA) are involved in tumor development and are commonly dysregulated in PCA.22905187
Pancreatic carcinomaEpigenetic AlterationsFeasibility of fecal microRNAs as novel biomarkers for pancreatic cancer.22905187
PancreatitisEpigenetic AlterationsThe expression of the remaining three miRNAs (miR-21, -210 and -375) remained unchanged among controls and the patients with either chronic pancreatitis or PCA.22905187
Breast Carcinoma Metastatic in the BoneEpigenetic AlterationsSerum overexpression of microRNA-10b in patients with bone metastatic primary breast cancer.22906258
HypospadiasEpigenetic AlterationsGenome-wide DNA methylation profiling of CpG islands in hypospadias.22906644
HypospadiasEpigenetic AlterationsOur findings suggest DNA methylation patterns are useful in identifying new genes such as SCARB1 and MYBPH that may be involved in the etiology of hypospadias.22906644
Colorectal CarcinomaEpigenetic AlterationsThe topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers.22911899
Carcinoma of lungEpigenetic AlterationsDysfunctions associated with methylation, microRNA expression and gene expression in lung cancer.22912875
Carcinoma of lungEpigenetic AlterationsBy comparing the MCC ranks of methylation, microRNA and mRNA for each GO term, we classified the GO sets into six groups and identified the dysfunctional methylation, microRNA and mRNA gene sets in lung cancer.22912875
Prostate Cancer PathwayEpigenetic AlterationsGene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer.22915211
Prostate Cancer PathwayEpigenetic AlterationsSFRP2 methylation in combination with other epigenetic markers may be a useful biomarker of prostate cancer.22915211
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsEpigenetic aberrations have been reported in hepatocellular carcinoma (HCC).22915658
NeoplasmsEpigenetic AlterationsEpigenetic therapy with belinostat demonstrates tumor stabilization and is generally well-tolerated.22915658
Chronic Lymphocytic LeukemiaEpigenetic Alterations450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments.22922567
Chronic Lymphocytic LeukemiaEpigenetic AlterationsIntriguingly, CLL prognostic genes (for example, CLLU1, LPL, ZAP70 and NOTCH1), epigenetic regulator (for example, HDAC9, HDAC4 and DNMT3B), B-cell signaling (for example, IBTK) and numerous TGF-b and NF-kB/TNF pathway genes were alternatively methylated between subgroups.22922567
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer.22923190
Carcinoma of lungEpigenetic AlterationsWe found that lung cancer cells or tissues had significantly different DNA methylation and mRNA levels than normal human bronchial epithelial cells or adjacent non-tumorous tissues, respectively.22923190
Carcinoma of lungEpigenetic AlterationsHigh DNA methylation of ILs promoters in lung cancer cells or tissues was associated with low mRNA levels.22923190
Primary malignant neoplasmEpigenetic AlterationsWe found an inverse correlation between DNA methylation of IL1B, IL6, and IL8 gene promoters and their corresponding mRNA levels, such inverse correlation was more significant for IL1B (i.e., all cancer cell lines used in this study had a hypermethylated IL1B promoter which was associated with silencing of the gene).22923190
Carcinoma of lungEpigenetic AlterationsOur results underline for the first time the role of epigenetic modifications in the regulation of the expression of key cytokines involved in the inflammatory response during lung cancer development.22923190
Leukemia, Myelocytic, AcuteEpigenetic AlterationsTo determine the role of DNA methylation in the progression of acute myeloid leukaemia (AML), we analysed the methylation status of ALOX12, GSTM1, HS3ST2 and FZD9 in 127 AML patients.22924777
Neuroendocrine TumorsEpigenetic AlterationsAltered expression of microRNA miR-21, miR-155, and let-7a and their roles in pulmonary neuroendocrine tumors.22924844
Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA) has a critical effect on tumorigenesis through post-transcriptional modification and is considered to be potential biomarkers for cancer diagnosis and treatment monitoring.22924844
Ovarian CarcinomaEpigenetic AlterationsMicroRNA expression in ovarian carcinoma and its correlation with clinicopathological features.22925189
Malignant neoplasm of ovaryEpigenetic AlterationsMicroRNA (miRNA) expression is known to be deregulated in ovarian carcinomas.22925189
Malignant neoplasm of ovary, ovarian neoplasmEpigenetic AlterationsHowever, limited data is available about the miRNA expression pattern for the benign or borderline ovarian tumors as well as differential miRNA expression pattern associated with histological types, grades or clinical stages in ovarian carcinomas.22925189
ovarian neoplasmEpigenetic AlterationsAberrant expression of miRNAs is common in ovarian tumor suggesting involvement of miRNA in ovarian tumorigenesis.22925189
CarcinomaEpigenetic AlterationsExpression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues.22925189
CarcinomaEpigenetic AlterationsAn additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues.22925189
Malignant neoplasm of ovaryEpigenetic AlterationsAmong ovarian carcinomas, expression of four miRNAs (miR-30a-3p, miR-30c, miR-30d, miR-30e-3p) was lowest in mucinous and highest in clear cell samples.22925189
Carcinogenesis, NeoplasmsEpigenetic AlterationsCpG island hypermethylation of gene promoters and regulatory regions is a well-known mechanism of epigenetic silencing of tumor suppressors and is directly linked to carcinogenesis.22925896
Breast CarcinomaEpigenetic AlterationsCirculating microRNAs in plasma as early detection markers for breast cancer.22927033
Breast CarcinomaEpigenetic AlterationsWe profiled miRNAs extracted from the plasma of early stage breast cancer patients (taken at the time-point of diagnosis) and healthy control individuals using TaqMan low-density arrays (TLDA).22927033
Breast CarcinomaEpigenetic AlterationsFour miRNAs (miR-148b, miR-376c, miR-409-3p and miR-801) were shown to be significantly upregulated in the plasma of breast cancer patients.22927033
Breast CarcinomaEpigenetic AlterationsIn conclusion, the identified miRNAs might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer.22927033
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations, such as CpG islands methylation and histone modifications, are recognized key characteristics of cancer.22927297
NeoplasmsEpigenetic AlterationsGlycogenes are a group of genes which epigenetic status was found to be changed in several tumors.22927297
Prostate Cancer PathwayEpigenetic AlterationsGenistein suppresses prostate cancer growth through inhibition of oncogenic microRNA-151.22928040
Meningioma, NeoplasmsEpigenetic AlterationsWe conclude that hypermethylation of the promoter of hMLH1 is an epigenetic change in meningiomas and is associated with the tumor grade, while microsatellite instability is an uncommon event in meningiomas.22930430
Breast CarcinomaEpigenetic AlterationsAberrant DNA methylation constitutes a well-established epigenetic marker for breast cancer.22930747
Diffuse Large B-Cell LymphomaEpigenetic AlterationsAgilent Human miRNA Microarray 16.0 was used to detect the expression of micro-RNAs in paraffin-embedded tissue of 24 cases of DLBCL that had available clinical follow-up.22932402
Malignant Neoplasms, Breast CarcinomaEpigenetic AlterationsDysregulation of microRNAs is a common feature in human cancers, including breast cancer (BC).22935141
Squamous cell carcinoma, SERPINB3 wt AlleleEpigenetic AlterationsEpigenetic silencing of cancer-related genes plays an important role in oral/oropharyngeal squamous cell carcinoma (OSCC).22936053
Colorectal Cancer PathwayEpigenetic AlterationsAssociation of polymorphisms in microRNA-binding sites and colorectal cancer in an Iranian population.22939228
Clinical CoordinatorEpigenetic AlterationsFinally, we can conclude that a significant relationship exists between the miRNA-binding site polymorphism of the IL-16 gene and CRC risk in the Iranian population.22939228
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are agents of post-transcriptional gene expression, and they can affect many functions of an individual cell or tissue from extracellular matrix production to inflammatory processes and tumor development.22939228
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsRestoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101.22943841
Atrial FibrillationEpigenetic Alterations[Differential expressions of miRNAs in patients with nonvalvular atrial fibrillation].22944230
Atrial FibrillationEpigenetic AlterationsTo detect the differential expressions of miRNAs in left atrial appendage (LAA) in patients with atrial fibrillation (AF).22944230
Degenerative polyarthritisEpigenetic AlterationsSerum non-coding RNAs as biomarkers for osteoarthritis progression after ACL injury.22944527
Cartilage damageEpigenetic AlterationsThis study suggests serum non-coding RNAs may serve as novel noninvasive biomarkers for the detection and assessment of cartilage damage after ACL injury.22944527
Cartilage damageEpigenetic AlterationsInitial TaqMan array miRNA profiling showed an increased serum concentration of a small nucleolar RNA (snoRNA), U48, in five patients with cartilage damage compared with that in five patients without cartilage damage and six normal donors.22944527
CarcinogenesisEpigenetic AlterationsSarco (endo)plasmic reticulum Ca(2+)-ATPase (SERCAs) 3 is involved in calcium mobilization from endoplasmic reticulum into cytosol and closely links to metabolism, neuronal plasticity, gene transcription, cell growth, differentiation, apoptosis, protein folding, and carcinogenesis.22948776
CarcinogenesisEpigenetic AlterationsMicroRNA is a naturally occurring class of non-coding RNA molecules that mediate posttranscriptional gene regulation and are strongly implicated in cellular processes such as cell proliferation, carcinogenesis, cell survival and apoptosis.22954303
Malignant neoplasm of urinary bladderEpigenetic AlterationsmiRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer.22954303
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsWe profiled the expression of 671 miRNAs in formalin fixed paraffin embedded tumors from patients with advanced bladder cancer treated with cisplatin based chemotherapy.22954303
NeoplasmsEpigenetic AlterationsWe delineated differentially expressed miRNAs in tumors from patients with complete response vs. patients with progressive disease and in tumors form patients with short and long overall survival time.22954303
Malignant neoplasm of urinary bladderEpigenetic AlterationsFurthermore, we studied the effect of up- and down regulation of key miRNAs on the cisplatin sensitivity in eight bladder cancer cell lines with different sensitivities to cisplatin.22954303
NeoplasmsEpigenetic AlterationsMicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours.22954417
Stomach CarcinomaEpigenetic AlterationsThus, we hypothesised that the quantitative detection of the miR-200 family as epithelial-specific microRNAs in the blood could be a useful clinical biomarker for gastric cancer (GC).22954417
Admitting diagnosisEpigenetic AlterationsThus, epigenetic mechanisms that regulate gene expression might have an important role in AD.22954668
NeoplasmsEpigenetic AlterationsWe aimed to estimate the prognostic value of DNA methylation of tumor suppressor genes from pleural fluid.22954699
Neoplastic diseaseEpigenetic AlterationsAlthough epigenetic changes are commonly related to human neoplasia, scarce date is available on patients with MPE.22954699
Psychotic DisordersEpigenetic AlterationsDNA methylation/demethylation network expression in psychotic patients with a history of alcohol abuse.22958170
Schizophrenia, Bipolar Disorder, Psychotic DisordersEpigenetic AlterationsWe recently reported that DNA methylation dynamics are altered in brains of psychotic (PS) patients, including schizophrenia and bipolar disorder patients.22958170
Psychotic DisordersEpigenetic AlterationsAdditional investigation may also be necessary to determine whether the altered DNA methylation dynamics are direct or the consequence of an indirect interaction of alcohol with the neuropathogenetic mechanisms underlying psychosis.22958170
Chronic Kidney DiseasesEpigenetic AlterationsEvidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD).22960330
Chronic Kidney DiseasesEpigenetic AlterationsWe quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy.22960330
Chronic Kidney DiseasesEpigenetic AlterationsOur results suggest that urinary miRNA profiling has the potential of further development as biomarkers of CKD.22960330
Chronic Kidney DiseasesEpigenetic AlterationsMicro-RNA expression in the urinary sediment of patients with chronic kidney diseases.22960330
cervical cancerEpigenetic AlterationsClinico-epigenetic combination including quantitative methylation value of DKK3 augments survival prediction of the patient with cervical cancer.22961207
Cervix carcinomaEpigenetic AlterationsWe assessed the quantitative methylation levels of DKK3 in cervical carcinoma, determined the potential clinical correlations, and tested whether the combination of clinical and epigenetic factors augmented the prediction power of prognosis.22961207
Malignant neoplasm of urinary bladderEpigenetic AlterationsCell-free microRNAs in urine as diagnostic and prognostic biomarkers of bladder cancer.22961325
Malignant neoplasm of urinary bladderEpigenetic AlterationsUrinary cell-free miRNAs show promise as noninvasive biomarkers for diagnosis and recurrence of bladder cancer.22961325
Stomach CarcinomaEpigenetic AlterationsAberrant DNA methylation is implicated in the epigenetic field defect seen in gastric cancer.22961779
Stomach CarcinomaEpigenetic AlterationsAberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer.22961779
Stomach CarcinomaEpigenetic AlterationsCollectively, our data suggest that RASGRF1 methylation is significantly involved in an epigenetic field defect in the stomach, and that it could be a useful biomarker to identify individuals at high risk for gastric cancer.22961779
Carcinoma of lungEpigenetic AlterationsDNA methylation biomarkers offer improved diagnostic efficiency in lung cancer.22962272
Lung NeoplasmsEpigenetic AlterationsThese findings clearly show the impact of DNA methylation-based assays in the diagnosis of cytologically occult lung neoplasms.22962272
MeningiomaEpigenetic AlterationsWe propose that this gene repression may be caused by gene promoter hypermethylation, as in the case of UCHL1 and SFRP1, suggesting that this epigenetic event, together with loss of specific chromosomal regions, may play an important role in meningioma progression and recurrence.22964784
Colorectal CarcinomaEpigenetic AlterationsFunctional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas.22966016
Clinical CoordinatorEpigenetic AlterationsSeveral dietary and lifestyle factors can modulate DNA methylation suggesting that they may influence CRC risk through epigenetic regulation of cancer-related genes.22966878
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic Alterations[DNA methylation status of RARb2 and p16(INK4a) in peripheral blood and tumor tissue in patients with esophageal squamous cell carcinoma].22967446
Antilymphocyte SerumEpigenetic AlterationsCompared to healthy controls, miRNA 23a, 29b, 206 and 455 were increased in skeletal muscle of ALS patients.22975021
Amyotrophic Lateral SclerosisEpigenetic AlterationsDisruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis.22975021
Abnormality of mitochondrial metabolism, Antilymphocyte SerumEpigenetic AlterationsThese results show that skeletal muscle mitochondrial dysfunction in ALS patients is associated with a reduction in PGC-1a signalling networks involved in mitochondrial biogenesis and function, as well as increases in several miRNAs potentially implicated in skeletal muscle and neuromuscular junction regeneration.22975021
Paraganglioma of head and neckEpigenetic AlterationsIdentification of a signaling axis HIF-1a/microRNA-210/ISCU independent of SDH mutation that defines a subgroup of head and neck paragangliomas.22977270
NeoplasmsEpigenetic AlterationsTo get some insights into the hypoxic/pseudohypoxic molecular basis of HNPGLs, we attempted to define the gene, microRNA (miRNA), and HIF-1a expression patterns that distinguish tumors from normal paraganglia tissue.22977270
Cerebrovascular accident, Hypertensive diseaseEpigenetic AlterationsMetalloproteins and metals play key roles in epigenetic events in living organisms, including hypertension, the most important modifiable risk factor for stroke.22983496
Endometrial Endometrioid AdenocarcinomaEpigenetic AlterationsDiagnostic and prognostic significance of miRNA signatures in tissues and plasma of endometrioid endometrial carcinoma patients.22987275
NeoplasmsEpigenetic AlterationsTwo miRNA signatures: miR-92a/miR-410 and miR-92a/miR-205/miR-410 classified tumor tissues with higher accuracy in comparison to single miRNAs (AUC: 0.977, 95% CI: 0.927-0.996 and 0.984, 95% CI: 0.938-0.999, respectively).22987275
Colorectal CarcinomaEpigenetic AlterationsGenetic and epigenetic factors in regulation of microRNA in colorectal cancers.22989523
Malignant NeoplasmsEpigenetic AlterationsStudies on miRNA profiling revealed that a large number of them are significantly deregulated in human cancers.22989523
NeoplasmsEpigenetic AlterationsLike miRNAs, snoRNAs are globally down-regulated in tumor cells compared with their normal counterparts.22990019
Colorectal Cancer PathwayEpigenetic AlterationsUsefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer.22990173
Clinical CoordinatorEpigenetic AlterationsThis study showed the most sensitive epigenetic markers, E-cadherin (60 %), followed by APC (57 %), for detecting CRC.22990173
Clinical CoordinatorEpigenetic AlterationsIn this study, E-cad and APC genes may be particularly useful epigenetic biomarkers in plasma for the detection of CRC.22990173
Hollings Cancer CenterEpigenetic AlterationsWe previously demonstrated that deregulation of epigenetic regulators is a common event in human HCC.22991213
Adenomatous Polyposis Coli, Antigen-Presenting Cells, Neoplasms, Malignant neoplasm of urinary bladderEpigenetic AlterationsEpigenetic alterations of adenomatous polyposis coli (APC), retinoic acid receptor beta (RARb) and survivin genes in tumor tissues and voided urine of bladder cancer patients.22992440
ReducedEpigenetic AlterationsOur results suggest that a total (cytogenetic and epigenetic) functional loss of both EMP3 alleles accounts for the reduced disease progression-free interval in OII patients.22992787
Childhood LeukemiaEpigenetic AlterationsOncogenic Bmi-1 (B-lymphoma Moloney murine leukemia virus insertion region-1) belongs to the Polycomb-group (PcG) family of proteins and plays an important role in the regulation of proliferation, senescence, cell cycle and apoptosis, chromosome stability, activation of gene transcription.22994774
Clinical CoordinatorEpigenetic AlterationsOur integrative genomic and epigenetic analysis suggests early onset of CIMP during CRC development and indicates a previously unknown CRC development pathway in which epigenetic instability associates with genomic alterations.22995252
Stomach CarcinomaEpigenetic AlterationsPrognostic implications for high expression of oncogenic microRNAs in advanced gastric carcinoma.22996433
Malignant Neoplasms, Stomach CarcinomaEpigenetic AlterationsAberrant expressions of specific microRNAs are recently known in many malignancies, including gastric carcinoma.22996433
Transitional cell carcinoma of bladderEpigenetic AlterationsStage, grade and behavior of bladder urothelial carcinoma defined by the microRNA expression profile.22999546
Carcinoma, Transitional CellEpigenetic AlterationsWe identified miRNA expression profiles in urothelial carcinoma that are associated with grade, stage, and recurrence-free and disease specific survival.22999546
NeoplasmsEpigenetic AlterationsThe other miRNAs were present at levels similar to those of normal bladder tissue or under expressed in each tumor group.22999546
Carcinoma, Transitional CellEpigenetic AlterationsFour miRNAs were differentially expressed in the 2 urothelial carcinoma groups.22999546
Carcinoma, Transitional CellEpigenetic AlterationsmiRNAs could be incorporated into the urothelial carcinoma molecular pathway.22999546
Squamous Cell Carcinoma of the PenisEpigenetic AlterationsHistone methylation defines an epigenetic entity in penile squamous cell carcinoma.22999995
CarcinogenesisEpigenetic AlterationsHistone methylation patterns are frequently altered during carcinogenesis.22999995
Primary malignant neoplasmEpigenetic AlterationsHistone methylation levels defined an epigenetic entity that allowed accurate differentiation of cancer and normal samples.22999995
Penis carcinomaEpigenetic AlterationsThe description of a definite epigenetic entity in penile carcinoma provides a rationale for testing epigenetic agents in patients with metastatic disease.22999995
CarcinogenesisEpigenetic AlterationsAdequate folate status may protect against colorectal carcinogenesis through mechanisms involving adequate DNA methylation in the genome.23001241
Epstein-Barr virus associated gastric carcinomaEpigenetic AlterationsEpigenetic silencing of WNT5A in Epstein-Barr virus-associated gastric carcinoma.23001722
SF3B1 wt AlleleEpigenetic AlterationsThe Dab2 gene is inactivated in MDS in part by DNA methylation, and the suppression of Dab2 expression by DNA methylation may play a role in the development of MDS.23005040
Stomach CarcinomaEpigenetic AlterationsIdentification of recurrence-related genes by integrating microRNA and gene expression profiling of gastric cancer.23007704
Primary malignant neoplasmEpigenetic AlterationsWe previously analyzed the microRNA (miRNA) expression pattern in gastric cancer with and without recurrence and obtained 17 differentially expressed miRNAs with potential to predict recurrence risk for GC patients.23007704
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsTumor samples from 155 patients with stages IIIB to IV NSCLC who received EGFR-TKI therapy were analyzed for DNA methylation status of Wnt antagonist genes, including SFRP1, SFRP2, SFRP5, DKK3, WIF1, and APC, using methylation specific PCR (MSP) method.23009178
Clinical Coordinator, CarcinogenesisEpigenetic AlterationsDNA methylation is a common event in CRC where it is now considered an important phenomenon in CRC carcinogenesis and useful for the classification and prognosis of CRC.23010642
Clinical CoordinatorEpigenetic AlterationsTo gain insight into the molecular mechanisms underpinning CRC in Saudi Arabian patients, we profiled the DNA methylation frequency of key genes (MLH1, MSH2, RASSF1A, SLIT2, HIC1, MGMT, SFRP1, MYOD1, APC, CDKN2A, as well as five CIMP markers) in 120 sporadic CRC cases.23010642
Malignant Neoplasms, Primary malignant neoplasm, Squamous cell carcinoma of esophagusEpigenetic AlterationsThe association of microRNAs (miRs) with cancer progression has been established in many cancers including esophageal squamous cell carcinoma (ESCC).23013135
Endometrial adenocarcinomaEpigenetic AlterationsQuantitative assessment of DNA methylation for the detection of cervical and endometrial adenocarcinomas in liquid-based cytology specimens.23016466
Cervical Intraepithelial NeoplasiaEpigenetic AlterationsMethylated DNA Immunoprecipitation (MeDIP) combined with DNA microarray was used to compare DNA methylation profiles of epithelial cells derived from high-grade CIN lesions with normal cervical epithelium.23018867
Cervical Intraepithelial NeoplasiaEpigenetic AlterationsIn conclusion, our newly identified hypermethylated DMRs represent specific DNA methylation patterns in high-grade CIN lesions and are candidate biomarkers for early detection.23018867
cervical cancerEpigenetic AlterationsEpigenetic modifications, such as aberrant DNA promoter methylation, are frequently observed in cervical cancer.23018867
Aneuploidy, Chordoma, NeoplasmsEpigenetic AlterationsOur data suggest that chromosome 3 aneuploidy and epigenetic regulation of FHIT contribute to loss of the FHIT tumor suppressor in chordoma.23019410
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAcute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene.23022987
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAcute myeloid leukemia (AML) with t(8;16)(p11;p13) (t(8;16) AML) has unique clinico-biological characteristics, but its microRNA pattern is unknown.23022987
Leukemia, Myelocytic, AcuteEpigenetic AlterationsHowever, there was no difference in methylation status between t(8;16) and other AML subtypes, either overall or in the microRNA promoter.23022987
Leukemia, Myelocytic, AcuteEpigenetic AlterationsIn conclusion, t(8;16) AML harbors a specific microRNA signature that is partially epigenetically regulated and targets RET proto-oncogene.23022987
Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe analyzed 670 microRNAs in seven patients with t(8;16) AML and 113 with other AML subtypes.23022987
Primary malignant neoplasmEpigenetic AlterationsCancer cells exhibit 2 types of deoxyribonucleic acid (DNA) methylation alterations: global DNA hypomethylation and site-specific CpG island promoter hypermethylation.23023202
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) have increasingly been implicated in regulating the malignant progression of cancer.23023232
Colorectal Cancer PathwayEpigenetic AlterationsmicroRNA-181a is associated with poor prognosis of colorectal cancer.23023298
Prostatic NeoplasmsEpigenetic AlterationsCollectively, these results indicate that histone modifications can contribute to TIMP3 repression in the absence of promoter hypermethylation, and suggest that the combination of histone modifying agents could restore TIMP3 expression in prostate tumors harboring aberrant histone modifications at the TIMP3 promoter.23023649
Prostate Cancer PathwayEpigenetic AlterationsHeterogeneous epigenetic regulation of TIMP3 in prostate cancer.23023649
Prostate Cancer PathwayEpigenetic AlterationsThe mechanisms involved in TIMP3 transcriptional repression are not fully understood, but evidence suggests that promoter hypermethylation may not be the predominant epigenetic alteration in prostate cancer.23023649
Acute Coronary SyndromeEpigenetic AlterationsEarly assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs.23023917
CO-methylating acetyl-CoA synthase activityEpigenetic AlterationsCirculating microRNAs hold great potential as novel early biomarkers for the management of suspected ACS patients.23023917
cervical cancerEpigenetic AlterationsPost-transcriptional and epigenetic regulation of antigen processing machinery (APM) components and HLA-I in cervical cancers from Uighur women.23024775
Primary malignant neoplasmEpigenetic AlterationsThe posttranscriptional regulation of HLA-I and APM expression may associate with epigenetic modifications in cancer development which was not described so far.23024775
Carcinogenesis, NeoplasmsEpigenetic AlterationsOur results suggested that epigenetic modifications are responsible for the aberrant expression of certain HLA-I and APM genes, and may help to understand unrevealed mechanisms of tumor escape from immune surveillance in cervical carcinogenesis.23024775
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs have been shown to be dysregulated in a variety of cancers.23026055
SepticemiaEpigenetic AlterationsFour serum microRNAs identified as diagnostic biomarkers of sepsis.23026916
SepticemiaEpigenetic AlterationsFour serum miRNAs were identified as novel biomarkers of sepsis.23026916
DiseaseEpigenetic AlterationsIn addition, we identified two robust miSNPs x 3utrSNPs interactions, one involving HLA-DPB1 rs1042448 and hsa-mir-219-1 rs107822, the second the H1F0 rs1894644 and hsa-mir-659 rs5750504, modulating the expression of the associated genes.As some of the aforementioned genes have previously been reported to reside at disease-associated loci, our findings provide novel arguments supporting the hypothesis that the genetic variability of miRNAs could also contribute to the susceptibility to human diseases.23029284
Lupus Erythematosus, SystemicEpigenetic AlterationsWe determined the expression of ITGAL, PRF1, KIR2DL4, CD70, and CD40LG in patients with SLE and performed correlations with the global DNA methylation status and the levels of three DNA methylation enzymes and two methyl CpG-binding domain (MBD) proteins.23029299
Adenocarcinoma of lung (disorder)Epigenetic AlterationsMicroRNA expression profiles of whole blood in lung adenocarcinoma.23029380
Carcinoma of lungEpigenetic AlterationsThe association of lung cancer with changes in microRNAs in plasma shown in multiple studies suggests a utility for circulating microRNA biomarkers in non-invasive detection of the disease.23029380
Carcinoma of lungEpigenetic AlterationsThese results suggest that whole blood microRNA expression profiles can be used to distinguish lung cancer cases from clinically relevant controls.23029380
NeoplasmsEpigenetic AlterationsThe epigenetic silencing of tumor suppressor genes plays an important role in gliomagenesis.23032906
Glioblastoma MultiformeEpigenetic AlterationsThe present work demonstrated that the epigenetic inactivation of TFPI-2 by promoter hypermethylation was a frequent and tumor-specific event in glioblastoma, and TFPI-2 promoter methylation might be considered as a prognostic marker in glioblastoma.23032906
Malignant NeoplasmsEpigenetic AlterationsA quantitative Malignancy Index Diagnostic System (qMIDS) was developed based on 14 FOXM1 (isoform B)-associated genes implicated in the regulation of the cell cycle, differentiation, ageing, genomic stability, epigenetic and stem cell renewal, and two reference genes.23034676
Carcinoma of lung, quercetinEpigenetic AlterationsInfluence of quercetin-rich food intake on microRNA expression in lung cancer tissues.23035181
Autoimmune Thyroid Disease PathwayEpigenetic AlterationsAssociation of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease.23039890
Autoimmune thyroid diseaseEpigenetic AlterationsTo clarify the association between factors regulating DNA methylation and the prognosis of autoimmune thyroid diseases (AITDs), we genotyped single nucleotide polymorphisms in genes encoding DNA methyltransferase 1 (DNMT1), DNMT3A, DNMT3B, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), which are enzymes essential for DNA methylation.23039890
Carcinoma of lungEpigenetic AlterationsTwo microRNA panels to discriminate three subtypes of lung carcinoma in bronchial brushing specimens.23043084
Small cell carcinoma of lung, Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe microRNA panels were applied as differentiators of SCLC from NSCLC and of SQ from AC in 207 bronchial brushing specimens.23043084
Small cell carcinoma of lung, Non-Small Cell Lung CarcinomaEpigenetic AlterationsTwo microRNA panels yielded high diagnostic accuracy in discriminating SCLC from NSCLC (miR-29a and miR-375; area under the curve [AUC], 0.991 and 0.982 for training and validation data set, respectively) and in differentiating SQ from AC (miR-205 and miR-34a; AUC, 0.977 and 0.982 for training and validation data set, respectively) in FFPE surgical lung specimens.23043084
Small cell carcinoma of lung, Non-Small Cell Lung CarcinomaEpigenetic AlterationsMoreover, the microRNA panels accurately differentiated SCLC from NSCLC (AUC, 0.947) and SQ from AC (AUC, 0.962) in bronchial brushing specimens.23043084
Carcinoma of lungEpigenetic AlterationsWe found two microRNA panels that accurately discriminated between the three subtypes of lung carcinoma in bronchial brushing specimens.23043084
Carcinoma of lungEpigenetic AlterationsThe identified microRNA panels may have considerable clinical value in differential diagnosis and optimizing treatment strategies based on lung cancer subtypes.23043084
Primary malignant neoplasmEpigenetic AlterationsMicroarrays were used to screen 723 microRNAs in laser-captured, microdissected cancer cells from 82 snap-frozen surgical lung specimens.23043084
Malignant NeoplasmsEpigenetic AlterationsMiRNA profiling is an emerging tool for the potential early detection of a variety of malignancies.23043708
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe five optimized miRNAs accurately clustered these eight retrospective patients into NSCLC positive cases and negative controls.23043708
ovarian neoplasmEpigenetic AlterationsWe compared miRNA expression profiles of an isogenic cisplatin-sensitive and -resistant ovarian cancer cell line pair (A2780/A2780 DDP) and found 27 miRNAs to be differentially expressed (2-fold).23045278
DiseaseEpigenetic AlterationsCirculating microRNAs (miRNAs) have emerged as new biomarkers for human diseases.23051042
Carcinoma of lungEpigenetic AlterationsEpigenetic modifications are observed universally during the tumorigenesis of lung cancer.23053268
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe development of epigenetic-modulating agents utilizing the synergism between hypomethylating agents and histone deacetylase (HDAC) inhibitors provides a novel therapeutic approach in treating NSCLC.23053268
CarcinogenesisEpigenetic AlterationsDNA-methyltransferase (DNMT)-3A plays a crucial role in embryonic development and aberrant DNA methylation in carcinogenesis.23053986
SF3B1 wt AlleleEpigenetic AlterationsOur results provide further evidence for the involvement of epigenetic dysregulation in the pathogenesis of MDS.23055192
Neoplasms, Malignant Neoplasms, Malignant - descriptor, Carcinoma, Ovarian Epithelial, CarcinomaEpigenetic AlterationsThe aim of this study was to assess the extent of methylation of the RASSF1A and APC TSG promoters in ovarian epithelial adenomas, low malignant potential tumours and carcinomas in order to reveal a role for epigenetic TSG silencing in the development of these ovarian malignancies.23055343
Carcinoma, Cystadenoma, NeoplasmsEpigenetic AlterationsThe observed aberrant methylation frequencies of the RASSF1A and APC gene promoters indicate that an accumulation of epigenetic events at these specific TSG promoters may be associated with the malignant transformation of benign cystadenomas and LMP tumours to carcinomas.23055343
Bladder NeoplasmEpigenetic AlterationsAberrant DNA methylation is present in all bladder tumors and can be detected in urine specimens.23056278
Clinical CoordinatorEpigenetic AlterationsWe aimed to determine whether expression status of certain miRNAs might have prognostic/predictive value in CRC patients treated with conventional cytotoxic chemotherapies.23056401
Clinical CoordinatorEpigenetic AlterationsAmong the candidate miRNAs studied, miR-148a expression was most significantly down-regulated in advanced CRC tissues.23056401
Cell of Claudius, NeoplasmsEpigenetic AlterationsIn summary, the WNT7A gene is inactivated by genetic/epigenetic alterations in clear cell RCC and demonstrates tumor suppressor properties.23056560
Breast Carcinoma, NCOA5 geneEpigenetic AlterationsCIA identified miR-187 as a key miRNA associated with poor outcome in breast cancer.23060431
Glioblastoma MultiformeEpigenetic AlterationsPlasma micro-RNA-21 may be associated with glioblastoma development in individual cases.23061753
Chronic Lymphocytic LeukemiaEpigenetic AlterationsWe have also recognized a DNA methylation signature that distinguishes new clinico-biological subtypes of CLL.23064414
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe two molecular subtypes of CLL have differing DNA methylomes that seem to represent epigenetic imprints from distinct normal B-cell subpopulations.23064414
Leukemia, Myelomonocytic, ChronicEpigenetic AlterationsWe found that myelodysplastic chronic myelomonocytic leukemias are characterized by mutations in transcription/epigenetic regulators (ASXL1, RUNX1, TET2) and splicing genes (SRSF2) and the absence of mutations in signaling genes.23065512
Leukemia, Myelocytic, AcuteEpigenetic AlterationsA polymorphism in the 3-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia.23065518
nucleophosmin, Leukemia, Myelocytic, AcuteEpigenetic AlterationsTogether, our findings uncover a microRNA-mediated control of NPM1 expression that contributes to disease heterogeneity and suggest additional prognostic values of NPM1 in acute myeloid leukemia.23065518
Myeloproliferative diseaseEpigenetic AlterationsEven though mutations in epigenetic regulators frequently occur in myeloproliferative neoplasms, their effects on the epigenome have not been well studied.23066032
JAK2 NP_004963.1:p.V617FEpigenetic AlterationsIn contrast, the JAK2V617F mutation did not drive epigenetic clustering within MPNs.23066032
PRB1 gene, Thrombocytosis, PolycythemiaEpigenetic AlterationsThese results show epigenetic differences between PMF and polycythemia vera/essential thrombocytosis and reveal methylomic signatures of ASXL1 and TET2 mutations.23066032
Cardiovascular DiseasesEpigenetic AlterationsMicroRNAs (miRNAs) act by targeting 3-UTR mRNA, causing translational repression in physiological and pathological conditions, including cardiovascular diseases.23066896
Breast CarcinomaEpigenetic AlterationsSerum microRNA-155 as a potential biomarker to track disease in breast cancer.23071695
Primary malignant neoplasmEpigenetic AlterationsA growing body of evidence implicates the diagnostic potential of circulating miRNAs in cancer detection.23071695
Hemolytic-Uremic SyndromeEpigenetic AlterationsCirculating microRNAs in patients with Shiga-Toxin-producing E. coli O104:H4 induced hemolytic uremic syndrome.23071762
Neurologic SymptomsEpigenetic AlterationsCirculating microRNAs are strongly altered in this patient cohort and associated with neurological symptoms as well as platelet count.23071762
Primary Neoplasm, Magnetic-Targeted Carriers, MetastasisEpigenetic AlterationsNodal metastasis microRNA expression correlates with the primary tumour in MTC.23072640
Primary Neoplasm, Magnetic-Targeted CarriersEpigenetic AlterationsmiRNA expression patterns in nodal metastases significantly reflect those of the primary tumour in MTC.23072640
Clinical CoordinatorEpigenetic AlterationsIn addition to genetic aberrations, DNA methylation also plays important roles in the development of CRC.23073979
NeoplasmsEpigenetic AlterationsTumors with frequent DNA methylation were most strongly enriched in subgroups with infrequent CNAs.23073979
Epstein-Barr virus associated gastric carcinomaEpigenetic AlterationsRole of DNA methylation in the development of Epstein-Barr virus-associated gastric carcinoma.23073987
Epstein-Barr virus associated gastric carcinoma, NeoplasmsEpigenetic AlterationsDNA methylation of tumor suppressor genes that regulate the cell cycle and apoptosis specifically occurred in EBV-associated gastric carcinomas.23073987
Epstein-Barr virus associated gastric carcinomaEpigenetic AlterationsAberrant DNA methylation might lead to the development and progression of EBV-associated gastric carcinoma.23073987
Malignant tumor of colonEpigenetic AlterationsGenetic and epigenetic factors affecting DNA methylation and gene expression are known to be involved in the development of colon cancer, but the full range of genetic alterations and many key genes involved in the pathogenesis of colon cancer remain to be identified.23079973
Hepatitis B Virus-Related Hepatocellular CarcinomaEpigenetic AlterationsIdentification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma.23082062
Hepatitis B, Hollings Cancer CenterEpigenetic AlterationsTo identify the differentially expressed miRNAs and their targets in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC).23082062
Malignant neoplasm of urinary bladderEpigenetic AlterationsDetecting DNA methylation of the BCL2, CDKN2A and NID2 genes in urine using a nested methylation specific polymerase chain reaction assay to predict bladder cancer.23083854
Malignant neoplasm of urinary bladder, Primary malignant neoplasmEpigenetic AlterationsAs urine is easily attainable, bladder cancer is an optimal cancer to detect using DNA methylation.23083854
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is highly specific in cancer detection.23083854
Hepatitis BEpigenetic AlterationsHepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle.23091627
ovarian neoplasmEpigenetic AlterationsWe conclude that Nanog, which probably plays an important role in ovarian embryonic development, may be partially silenced in fertile and post-menopausal women, but is re-expressed in ovarian cancer, probably by epigenetic activation of Nanog gene expression.23092806
SF3B1 wt AlleleEpigenetic AlterationsOur results indicate that epigenetic regulation of the Wnt pathway in MDS cell line, and the methylation status of Wnt antagonists predicts prognoses of MDS patients.23093371
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is a mechanism for gene expression silencing in cancer.23093492
CarcinomaEpigenetic AlterationsUnsupervised clustering of DNA methylation profiles identified two groups of carcinomas, one with an elevated methylation level, evoking a CpG island methylator phenotype (CIMP).23093492
Colorectal Cancer PathwayEpigenetic AlterationsChanges in DNA methylation, whether hypo- or hypermethylation, have been shown to be associated with the progression of colorectal cancer.23096130
Carcinoma, AdenomaEpigenetic AlterationsWidespread changes in DNA methylation are seen in the transition from adenoma to carcinoma.23096130
Malignant neoplasm of liverEpigenetic AlterationsThe stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing.23097274
NeoplasmsEpigenetic AlterationsLin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7.23097274
Hollings Cancer CenterEpigenetic AlterationsOur results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins.23097274
Refractory Colorectal CarcinomaEpigenetic AlterationsMicroRNA profiling predicts survival in anti-EGFR treated chemorefractory metastatic colorectal cancer patients with wild-type KRAS and BRAF.23098991
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsSomatic mutations of epigenetic gene regulators are common in patients with myelodysplastic syndromes (MDS) and correlate with some clinical and laboratory features.23099237
Glioblastoma Multiforme PathwayEpigenetic AlterationsCorrelation of microRNA-375 downregulation with unfavorable clinical outcome of patients with glioma.23103713
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNA-375 (miR-375) is frequently demonstrated to be frequently dysregulated and functions as a tumor suppressor or an oncogene in different cancer types.23103713
GliomaEpigenetic AlterationsThis miRNA might function as a candidate unfavorable prognostic marker for human gliomas.23103713
Breast Carcinoma, Columnar Cell Lesion of the BreastEpigenetic AlterationsEpigenetic progression of columnar cell lesions of the breast to invasive breast cancer.23104224
Carcinogenesis, Columnar epithelial cell, NeoplasmsEpigenetic AlterationsPromoter hypermethylation of several tumour suppressor genes often occurs during breast carcinogenesis, but little is known about epigenetic silencing in the possible precursor columnar cell lesion (CCL).23104224
Stomach CarcinomaEpigenetic AlterationsDecreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer.23107361
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA let-7i has been proven to be down-regulated in many human malignancies and correlated with tumor progression and anticancer drug resistance.23107361
Glioblastoma Multiforme PathwayEpigenetic AlterationsEpigenetic biomarkers of T-cells in human glioma.23108258
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsTo explore epigenetic influences, promoter methylation of selected tumor suppressor genes was analyzed in early-stage NSCLC patients ranging in age from 30 to 87 years at diagnosis.23111194
Cutaneous Melanoma, CarubicinEpigenetic AlterationsPerturbations in microRNA (miRNA) expression profiles have been reported for cutaneous malignant melanoma (CMM) predominantly when examined in cell lines.23111773
Cutaneous MelanomaEpigenetic AlterationsDespite the rapidly growing number of newly discovered human miRNA sequences, the availability of up-to-date miRNA expression profiles for clinical samples of primary cutaneous malignant melanoma (PCMM), cutaneous malignant melanoma metastases (CMMM), and benign melanocytic nevi (BMN) is limited.23111773
CarubicinEpigenetic AlterationsIn addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples.23111773
CarubicinEpigenetic AlterationsThe results of this study partially confirm previous CMM miRNA profiling studies identifying miRNAs that are dysregulated in CMM.23111773
ArteriosclerosisEpigenetic AlterationsClarification of familial factors associated with DNA methylation and early atherosclerosis will provide important information to uncover clinical correlates of disease.23116433
ArteriosclerosisEpigenetic AlterationsAtherosclerosis is a complex process involving both genetic and epigenetic factors.23116433
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsOur results emphasize the importance of validating potential tumor markers in independent patient cohorts, and indicate that the role of miRNAs as colorectal cancer biomarkers is still undetermined.23121918
Hollings Cancer CenterEpigenetic AlterationsBoth KL gene expression and its promoter DNA methylation are predictive factors for the poor prognosis of HCC.23123137
Liver carcinomaEpigenetic AlterationsEpigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma.23123137
CarcinogenesisEpigenetic AlterationsTherefore, our data suggested that inactivation of the FHL1 gene is a frequent event during oral carcinogenesis and that the mechanism of FHL1 downregulation in OSCCs is through DNA methylation of the promoter region rather than histone deacetylation or mutation.23123766
Malignant neoplasm of breastEpigenetic AlterationsHOTAIR expression and DNA methylation were analyzed in tissue from 348 primary breast cancers with quantitative RT-PCR and methylation-specific PCR, respectively.23124417
Breast CarcinomaEpigenetic AlterationsThese findings suggest that the intergenic DNA methylation may have important biologic relevance in regulating HOTAIR expression, and that HOTAIR expression may not be an independent prognostic marker in breast cancer, but needs further validation in independent studies.23124417
Breast CarcinomaEpigenetic AlterationsAssociation of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer.23124417
Primary Neoplasm, Primary malignant neoplasmEpigenetic AlterationsGlobal microRNA profiling in favorable prognosis subgroups of cancer of unknown primary (CUP) demonstrates no significant expression differences with metastases of matched known primary tumors.23124598
Malignant neoplasm of ovary, Breast Adenocarcinoma, Head and Neck NeoplasmsEpigenetic AlterationsSubsequently, we profiled the expression of 733 microRNAs (miRs) in the CUP cases and compared results with metastases from 20 ovarian carcinomas, 10 breast adenocarcinomas, 20 squamous head neck or lung tumors.23124598
Squamous cell carcinoma of esophagusEpigenetic AlterationsDifferential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma.23124769
Primary malignant neoplasmEpigenetic AlterationsTumor-specific microRNAs (miRNAs) seem to be potential biomarkers for the early diagnosis and treatment of cancer.23124769
Esophageal carcinoma, Squamous cell carcinoma of esophagusEpigenetic AlterationsTherefore, there is a set of differentially expressed miRNAs in esophageal cancer which may be associated with the incidence and development of ESCC.23124769
Squamous cell carcinoma of esophagusEpigenetic AlterationsDifferential expression profiles of miRNAs in ESCC may be promising biomarkers for the early screening of high-risk populations and early detection.23124769
NeoplasmsEpigenetic AlterationsDisturbances in the epigenetic landscape by aberrant methylation of CpG islands can lead to inactivation of cancer-related genes in solid tumors.23125005
Nasopharyngeal carcinomaEpigenetic AlterationsMicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN.23125220
NeoplasmsEpigenetic AlterationsRecently, downregulation of tumor suppressor genes expression by microRNA (miRNA) is increasingly recognized as an important mechanism of nasopharyngeal tumorigenesis.23125220
Chronic Lymphocytic LeukemiaEpigenetic AlterationsEpigenetic profile in chronic lymphocytic leukemia using methylation-specific multiplex ligation-dependent probe amplification.23130831
Malignant tumor of colonEpigenetic AlterationsThe epigenetic silencing of KiSS-1 by hypermethylation was tested in colon cancer cells (n = 5) before and after azacytidine treatment.23132294
Glioblastoma MultiformeEpigenetic AlterationsEpigenetic silencing of Id4 identifies a glioblastoma subgroup with a better prognosis as a consequence of an inhibition of angiogenesis.23132729
Adenoma of large intestineEpigenetic AlterationsPlasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas.23132835
Colorectal Cancer PathwayEpigenetic AlterationsLow concentrations of folate, other B vitamins, and methionine are associated with colorectal cancer risk, possibly by changing DNA methylation patterns.23132835
Carcinoma of lung, NeoplasmsEpigenetic AlterationsMicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer.23133627
Carcinoma of lungEpigenetic AlterationsWe further showed that miR-574-5p was the mostly up-regulated miRNA in human lung cancer cells under TLR9 signaling by miRNA array analysis.23133627
Carcinoma of lung, NeoplasmsEpigenetic AlterationsHere we characterized the potential role of miRNA-574-5p in enhanced tumor progression induced by TLR9 signaling in human lung cancer.23133627
NeoplasmsEpigenetic AlterationsNotably, we found that down-regulation of miRNA-574-5p using miR-574-5p inhibitor in vitro or miR-574-5p sponge in vivo significantly abrogated the enhanced tumor progression induced by TLR9 signaling.23133627
NeoplasmsEpigenetic AlterationsNotably, we identified checkpoint suppressor 1 (Ches1) as the dominant direct target for miRNA-574-5p to confer the TLR9 signaling enhanced tumor progression.23133627
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsOur findings not only facilitated the further understanding of the crosstalk between miRNAs and TLRs in tumor biology, but also provided novel potential candidates for treatment of cancer.23133627
Myocardium, Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsRelation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction.23137501
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsCirculating microRNAs (miRs) have emerged as potential diagnostic markers in patients with myocardial infarction.23137501
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsTransporter gene expression in human head and neck squamous cell carcinoma and associated epigenetic regulatory mechanisms.23137910
Squamous cell carcinoma of the head and neck, NeoplasmsEpigenetic AlterationsIn summary, the expression of drug transporters (i) is markedly changed in HNSCC tumor tissues compared with normal mucosa, (ii) might be predictive of the outcome of patients with HNSCC, and (iii) is affected by novel epigenetic therapies and is further modulated by nuclear receptor-mediated mechanisms.23137910
Malignant NeoplasmsEpigenetic AlterationsBecause PcG-associated aberrant DNA methylation is a hallmark of several human malignancies, our methylation data suggest that epigenetic reprogramming of pluripotency genes may initiate cell immortalization.23143272
Primary malignant neoplasmEpigenetic AlterationsMammalian cells acquire epigenetic hallmarks of human cancer during immortalization.23143272
Primary malignant neoplasmEpigenetic AlterationsUnlike genetic alterations, epigenetic changes are reversible events, and as such, can be amenable to pharmacological interventions, which makes them appealing targets for cancer therapy when genetic approaches prove inadequate.23143272
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsHowever, studies of direct link between estrogen (especially estradiol E2), miRNA expression, and MMR in colorectal cancer (CRC) have not been done.23143558
Breast CarcinomaEpigenetic AlterationsIndependent T-test was used to detect significant correlation between miRNA expression level and the different clinicopathological features for breast cancer.23144930
Malignant neoplasm of breastEpigenetic AlterationsValidation of expression patterns for nine miRNAs in 204 lymph-node negative breast cancers.23144930
Humor, CataractEpigenetic AlterationsMicroRNA in aqueous humor from patients with cataract.23146683
Glaucoma, CTCAEEpigenetic AlterationsFurther analysis of the AH miRNA population may identify potential gene targets and provide insights regarding their roles in AH regulation, glaucoma and anterior segment disease processes.23146683
Humor, CataractEpigenetic AlterationsWe analyzed aqueous humor (AH) from human subjects undergoing cataract surgery to establish the presence and relative quantities of known miRNAs.23146683
Refractory Cytopenia of ChildhoodEpigenetic AlterationsWe determined global miRNA expression profiles of RCC and parallel renal parenchyma tissues by using quantitative reverse transcriptase-polymerase chain reaction-based TaqMan low-density arrays.23150176
Refractory Cytopenia of ChildhoodEpigenetic AlterationsFunctional in vitro experiments were performed on ACHN and CAKI-2 RCC cell lines transfected with miRNA-210 inhibitor.23150176
Carcinogenic Chlorinated HydrocarbonEpigenetic AlterationsThe resulting miRNA expression was compared to the stage or grade of CHC determined by blood examination and histological inspection.23152743
Carcinogenic Chlorinated Hydrocarbon, Hepatitis, Fibrosis, LiverEpigenetic AlterationsAdditionally, we could link miRNA expression pattern with liver fibrosis stage and grade of liver inflammation in CHC.23152743
InflammationEpigenetic AlterationsIn particular, the miRNA expression pattern for early fibrotic stage differed greatly from that observed in high inflammation grades.23152743
Liver diseasesEpigenetic AlterationsWe demonstrated that miRNA expression pattern in exosome rich fractionated serum shows a high potential as a biomarker for diagnosing the grade and stage of liver diseases.23152743
Carcinoma, Transitional Cell, Adenocarcinoma of lung (disorder)Epigenetic AlterationsInducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder.23153939
Malignant Neoplasms, SDHB protein, human, NeoplasmsEpigenetic AlterationsFurthermore, a constitutional SDHB mutation is proposed to predispose for an epigenetic tumor phenotype occurring before the emanation of clinically recognized malignancy.23154831
Pancreatic carcinomaEpigenetic AlterationsHigh-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer.23155457
Malignant NeoplasmsEpigenetic AlterationsYes-associated protein (YAP) plays an important role in signal transduction and gene transcription regulation in normal cells, with elevated and over-expressed YAP levels observed in various malignant tumors.23158133
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDecitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia.23158571
Prostate Cancer PathwayEpigenetic AlterationsWe determined whether a novel combination of field defect DNA methylation markers could predict the presence of prostate cancer using histologically normal transrectal ultrasound guided biopsy cores.23159584
Prostate Cancer PathwayEpigenetic AlterationsUsing the epigenetic field defect to detect prostate cancer in biopsy negative patients.23159584
Prostate Cancer PathwayEpigenetic AlterationsA widespread epigenetic field defect can be used to detect prostate cancer in patients with histologically negative biopsies.23159584
Kidney Failure, AcuteEpigenetic AlterationsMicroRNA-494 reduces ATF3 expression and promotes AKI.23160513
Necrosis, Kidney Failure, AcuteEpigenetic AlterationsMicroRNA-494 mediates apoptosis and necrosis in several types of cells, but its renal target and potential role in AKI are unknown.23160513
Kidney Failure, AcuteEpigenetic AlterationsIn humans, urinary microRNA-494 levels were 60-fold higher in patients with AKI than normal controls.23160513
Injury of kidneyEpigenetic AlterationsIn conclusion, upregulation of microRNA-494 contributes to inflammatory or adhesion molecule-induced kidney injury after ischemia/reperfusion by inhibiting expression of ATF3.23160513
Kidney Failure, AcuteEpigenetic AlterationsFurthermore, microRNA-494 may be a specific and noninvasive biomarker for AKI.23160513
Coronary Artery DiseaseEpigenetic AlterationsOxidative stress in coronary artery disease: epigenetic perspective.23160801
Breast CarcinomaEpigenetic AlterationsEpigenetic regulation, has been very scarcely explored in familial breast cancer (BC).23160909
Breast CarcinomaEpigenetic AlterationsDifferent methylation and microRNA expression pattern in male and female familial breast cancer.23160909
Colorectal Cancer Pathway, cetuximabEpigenetic AlterationsLet-7 miRNA-binding site polymorphism in the KRAS 3UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/- cetuximab.23167843
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are small non-coding RNAs playing significant roles in the pathogenesis of many cancers including rectal cancer.23167930
Primary malignant neoplasmEpigenetic AlterationsMicroRNA expression profile associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients.23167930
Primary malignant neoplasmEpigenetic AlterationsOur pilot study suggests that miRNAs are part of the mechanisms that are involved in response of rectal cancer to the chemoradiotherapy and that miRNAs may be promising predictive biomarkers for such patients.23167930
Electrocardiogram: myocardial infarction (finding)Epigenetic Alterations[Urine cardiac specific microRNA-1 level in patients with ST segment elevation acute myocardial infarction].23168196
Electrocardiogram: myocardial infarction (finding)Epigenetic Alterations[Changes in cardiac specific microRNA-208a level in peripheral blood in ST segment elevation acute myocardial infarction patients].23168198
Corneal Endothelial Cell LossEpigenetic Alterations[Evaluation of circulating microRNA-92a for endothelial damage induced by percutaneous coronary intervention].23168199
Multiple MyelomaEpigenetic AlterationsIdentification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.23169280
Multiple MyelomaEpigenetic AlterationsThree serum microRNAs, miR-720, miR-1308 and miR-1246, were found to have potential as diagnostic biomarkers in myeloma.23169280
Multiple MyelomaEpigenetic AlterationsWe have developed a biomarker signature using microRNAs extracted from serum, which has potential as a diagnostic and prognostic tool for multiple myeloma.23169280
MyositisEpigenetic AlterationsThis leukocyte index was subsequently utilized to differentiate transcriptional changes due to leukocyte infiltration from other alterations in myositis muscle.23171592
MyositisEpigenetic AlterationsAlthough the role of miR-146a in myositis remains uncertain, our results highlight the potential benefit of deconvoluting the source of transcriptional changes in myositis muscle or other heterogeneous tissue samples.23171592
Primary malignant neoplasmEpigenetic AlterationsmiRNAs are small noncoding RNAs that participate in a variety of biologic processes, and dysregulation of miRNA is always associated with cancer development and progression.23171948
Lupus Erythematosus, Autoimmune Diseases, Rheumatoid Arthritis, MS geneEpigenetic AlterationsMicroRNA expression profiles have been identified in several autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis.23173724
Malignant neoplasm of urinary bladderEpigenetic AlterationsReduced expression of microRNA-100 confers unfavorable prognosis in patients with bladder cancer.23173870
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA-100 (miR-100) has been demonstrated to be downregulated in bladder cancer tissues, and enforced expression of this miRNA may inhibit cell growth and colony formation of human bladder cancer 5637 cells in vitro.23173870
Malignant neoplasm of urinary bladder, Primary malignant neoplasmEpigenetic AlterationsOur data offer the convincing evidence that miR-100 may play an important role in the progression of bladder cancer and that the reduced expression of this miRNA may be independently associated with shorter PFS and OS of patients, suggesting that miR-100 might be a potential marker for further risk stratification in the treatment of this cancer.23173870
Glioblastoma Multiforme PathwayEpigenetic AlterationsPlasma specific miRNAs as predictive biomarkers for diagnosis and prognosis of glioma.23174013
Malignant NeoplasmsEpigenetic AlterationsRecently, some researchers have demonstrated that plasma miRNAs are sensitive and specific biomarkers of various cancers.23174013
Glioblastoma Multiforme PathwayEpigenetic AlterationsThese findings suggest that plasma specific miRNAs have potential use as novel biomarkers of glioma and may be useful in clinical management for glioma patients.23174013
Pancreatic carcinomaEpigenetic AlterationsTo explore the clinical significance of miRNA-216a expression in pancreatic cancer.23174591
Pancreatic carcinomaEpigenetic AlterationsThe expression of miRNA-216a was significantly lower in pancreatic cancer than in benign pancreas lesions (P=0.000).23174591
NeoplasmsEpigenetic AlterationsIt has been suggested that SMARCB1 may be silenced by epigenetic changes in the remaining 90% of tumors.23174932
Squamous cell carcinoma of esophagusEpigenetic AlterationsmicroRNA and inflammatory gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma.23175214
Squamous cell carcinoma of esophagusEpigenetic AlterationsThese data were combined to generate a miRNA risk score that was significantly associated with worse prognosis (p = 0.0001), suggesting that these miRNAs may be useful prognostic classifiers for ESCC.23175214
Squamous cell carcinoma of esophagusEpigenetic AlterationsTherefore, miRNA and inflammatory gene expression patterns, alone or in combination, have potential as prognostic classifiers for ESCC and may help to guide therapeutic decisions.23175214
Squamous cell carcinoma of esophagusEpigenetic AlterationsMicroRNAs (miRNAs) and inflammatory genes have a role in the initiation and development of esophageal squamous cell carcinoma (ESCC).23175214
Stomach CarcinomaEpigenetic AlterationsMicroRNA-27a inhibitors alone or in combination with perifosine suppress the growth of gastric cancer cells.23175237
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-27a (miR-27a) is an oncogene that contributes to drug resistance in various types of cancer.23175237
Clinical CoordinatorEpigenetic AlterationsWe carried out comprehensive genome-scale DNA methylation profiling by Illumina Infinium HumanMethylation27 of 21 DNA pools that represent 84 CRC samples divided according to their high-, intermediate-, and low-methylation epigenotypes (HME, IME, and LME, respectively) and 70 normal-adjacent colonic tissues.23175427
Primary malignant neoplasm, Renal Cell Carcinoma PathwayEpigenetic AlterationsTumor-suppressive microRNA-135a inhibits cancer cell proliferation by targeting the c-MYC oncogene in renal cell carcinoma.23176581
Malignant Neoplasms, Metastasis, Primary malignant neoplasmEpigenetic AlterationsRecently, many studies have suggested that microRNAs (miRNAs) are involved in cancer cell development, invasion, and metastasis of various types of human cancers.23176581
AMD1 wt AlleleEpigenetic AlterationsFurthermore, we showed that hypomethylation of the IL17RC promoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RC may potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis.23177625
Non-MalignantEpigenetic AlterationsAll miRNAs were suitable to discriminate malignant from non-malignant tissue.23178446
Impaired, Right armEpigenetic AlterationsThe impaired apoptosis in RA synovium might result from increased autophagy, which in turn could be due to the deregulation of miRNA-30a.23178792
estrogen receptor-positive breast cancer, NeoplasmsEpigenetic AlterationsIn this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissue were compared between ER(high) Ki67(low) tumors and ER(low) Ki67(high) tumors by miRNA and mRNA microarrays.23183268
NeoplasmsEpigenetic AlterationsWe picked up 11 genes that were potential target genes of the selected miRNAs and that were differentially expressed in ER(high) Ki67(low) tumors and ER(low) Ki67(high) tumors.23183268
Fibrosis AssessmentEpigenetic AlterationsmiRNAs are novel regulators of organ fibrosis.23183523
Primary malignant neoplasmEpigenetic AlterationsExpression of miRNA associated with Gleason grading system may contribute to more accurate preoperative cancer risk evaluation.23184537
Prostate Cancer PathwayEpigenetic AlterationsExpression of microRNAs associated with Gleason grading system in prostate cancer: miR-182-5p is a useful marker for high grade prostate cancer.23184537
Prostate Cancer PathwayEpigenetic AlterationsExpression profiles of some microRNAs (miRNAs) were associated with clinicopathological findings in human prostate cancer (PC), but the relative expression of miRNAs among Gleason patterns (GPs) remains unclear.23184537
Breast CarcinomaEpigenetic AlterationsFurthermore miRNA-24 expression levels in breast cancer patient specimens showed no correlation with TRIB3 mRNA or TRIB3 protein levels, or with prognosis.23185332
Breast CarcinomaEpigenetic AlterationsThus, the expression of miRNA-24 does not explain the difference between mRNA and protein expression of TRIB3 in this cohort of breast cancer patients.23185332
Autoimmune hepatitis, Primary Biliary CholangitisEpigenetic AlterationsEpigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis.23187010
Autoimmune liver diseaseEpigenetic AlterationsEpigenetic changes are of crucial importance in the etiopathogenesis of autoimmune liver diseases.23187010
Cerebral Hemorrhage, HypertrophyEpigenetic AlterationsCirculating MicroRNAs as potential risk biomarkers for hematoma enlargement after intracerebral hemorrhage.23190933
Cerebral HemorrhageEpigenetic AlterationsMicroRNAs have recently been shown to regulate the downstream bioprocesses of intracerebral hemorrhage.23190933
helium, Infectious Canine HepatitisEpigenetic AlterationsWe demonstrated that multiple miRNAs are differentially expressed in the plasma of ICH patients with or without HE and may serve as circulating biomarkers for predicting HE after ICH.23190933
Autoimmune Diseases, Myasthenia GravisEpigenetic AlterationsMyasthenia gravis (MG) are T-cell dependent antibody-mediated autoimmune disorders, microRNAs are important regulators of human autoimmune disease pathogenesis.23196978
NeoplasmsEpigenetic AlterationsThis is the first report describing microRNA-mediated down-regulation of ATM leading to clinically manifest tumor radiosensitivity.23199656
Primary malignant neoplasmEpigenetic AlterationsOur results indicate that epigenetic silencing of miRNA genes may be involved in the development of BCa and that methylation of miRNA genes could be a useful biomarker for cancer detection.23200812
Malignant neoplasm of urinary bladderEpigenetic AlterationsMethylation of a panel of microRNA genes is a novel biomarker for detection of bladder cancer.23200812
Primary Neoplasm, Primary malignant neoplasmEpigenetic AlterationsBisulfite pyrosequencing was used to assess miRNA gene methylation in 5 cancer cell lines, 83 primary tumors, and 120 preoperative and 47 postoperative urine samples.23200812
Malignant neoplasm of urinary bladderEpigenetic AlterationsDysregulation of microRNAs (miRNAs) has been implicated in bladder cancer (BCa), although the mechanism is not fully understood.23200812
Cerebrovascular accidentEpigenetic AlterationsThe combined effects between microRNA polymorphisms and homocysteine/folate levels may contribute to stroke and SBI prevalence.23202363
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDecreased expression of microRNA-375 in nonsmall cell lung cancer and its clinical significance.23206448
Malignant NeoplasmsEpigenetic AlterationsEmerging evidence has shown the association of aberrant microRNA-375 (miR-375) expression with tumourigenesis in many types of human malignancy.23206448
ovarian neoplasmEpigenetic AlterationsEpigenetic and immunohistochemical characterization of the Clusterin gene in ovarian tumors.23208459
Malignant Ovarian Cyst, Serous cystadenoma, borderline malignancyEpigenetic AlterationsTo characterize abnormal epigenetic changes and protein expression of the clusterin gene in a large series of ovarian malignant and borderline tumors.23208459
Malignant NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs) are small non-coding RNAs that can function as endogenous silencers of target genes and play critical roles in human malignancies.23209550
Gastric Mucosa-Associated Lymphoid Tissue LymphomaEpigenetic AlterationsThese miRNAs might have potential application as therapeutic targets and novel biomarkers for gastric MALT lymphoma.23209550
Colorectal Cancer PathwayEpigenetic AlterationsGenome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer.23209692
Colorectal Cancer PathwayEpigenetic AlterationsWe employed a genome-scale marker discovery method to identify and verify candidate DNA methylation biomarkers for blood-based detection of colorectal cancer.23209692
Stomach CarcinomaEpigenetic AlterationsDetermination of plasma microRNA for early detection of gastric cancer.23212612
Carcinogenesis, NeoplasmsEpigenetic AlterationsWe demonstrated that miR-195-5p is a novel tumor suppressor miRNA and may contribute to gastric carcinogenesis.23212612
Liver carcinomaEpigenetic AlterationsFrequent concomitant epigenetic silencing of SOX1 and secreted frizzled-related proteins (SFRPs) in human hepatocellular carcinoma.23215838
Malignant NeoplasmsEpigenetic AlterationsExcept for genetic mutations, epigenetic changes are also involved in the development of human cancers.23215838
NeoplasmsEpigenetic AlterationsOur findings indicate pre-miRNA polymorphisms may predict tumor HPV16-positive SCCOP cases and may be prognostic biomarkers for SCCOP.23219900
Diabetic RetinopathyEpigenetic AlterationsEpigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: role of histone methylation.23221071
Diabetic RetinopathyEpigenetic AlterationsHistone methylation of retinal Sod2 has an important role in the development of diabetic retinopathy and in the metabolic memory phenomenon associated with its continued progression.23221071
Diabetic RetinopathyEpigenetic AlterationsTargeting enzymes important for histone methylation may serve as a potential therapy to halt the development of diabetic retinopathy.23221071
melanomaEpigenetic AlterationsThe rs2910164 G>C polymorphism in microRNA-146a is associated with the incidence of malignant melanoma.23222547
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-146a (miR-146a) is one of the microRNAs (miRNAs) implicated in the pathogenesis of various cancers.23222547
Adenocarcinoma, Carcinoma, NeuroendocrineEpigenetic AlterationsDiagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum.23224118
Colorectal CarcinomaEpigenetic AlterationsMethylation-specific multiple ligation-dependent probe amplification (MS-MLPA) is a fast, new, inexpensive method that has rarely been exploited in DNA methylation profiling of colorectal cancers (CRCs).23224118
NeoplasmsEpigenetic AlterationsMS-MLPA assay is an easy and reliable system for epigenetic characterization of tumor tissues and leads to a rapid identification of CRCs with the highest levels of gene methylation.23224118
Breast CarcinomaEpigenetic AlterationsThe microRNA maturation regulator Drosha is an independent predictor of outcome in breast cancer patients.23225145
NeoplasmsEpigenetic AlterationsThese observations provide further evidence that alterations in miRNA regulation influence tumour behaviour.23225145
Breast CarcinomaEpigenetic AlterationsDrosha is a protein that plays a key role in the biogenesis of microRNAs which are well known to be deranged in human breast cancer (BC).23225145
Asthma PathwayEpigenetic AlterationsThe results of the current study provide evidence for differential function of T cell subsets in monozygotic twins discordant for asthma that are regulated by changes in DNA methylation.23226205
Asthma PathwayEpigenetic AlterationsT cells mediate the inflammatory responses observed in asthma among genetically susceptible individuals and have been suspected to be prone to epigenetic regulation.23226205
Human Papillomavirus-Related Cervical Carcinoma, NeoplasmsEpigenetic AlterationsChanges in host tumor genome DNA methylation patterns are among the molecular alterations associated with HPV-related carcinogenesis.23226306
Anal squamous cell carcinomaEpigenetic AlterationsHowever, there is little known about the epigenetic changes associated specifically with the development of anal squamous cell cancer (SCC).23226306
Glioblastoma Multiforme PathwayEpigenetic AlterationsIncreased expression of microRNA-17 predicts poor prognosis in human glioma.23226946
Breast CarcinomaEpigenetic AlterationsAn induction of microRNA, miR-7 through estrogen treatment in breast carcinoma.23227519
Breast CarcinomaEpigenetic AlterationsEvaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer.23228090
Carcinogenesis, NeoplasmsEpigenetic AlterationsEmerging evidence has shown that miRNAs are involved in human carcinogenesis as tumor suppressors or oncogenes.23228090
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsTo gather more knowledge on microRNAs in human hepatocellular carcinoma (HCC) we generated a small RNA library in the human HCC cell line HA22T/VGH by cloning and sequencing the cDNA obtained following the size selection of 18-24 nucleotide RNAs.23229173
Hollings Cancer CenterEpigenetic AlterationsWe determined the expression levels of the most frequently cloned microRNAs by qPCR in HCC tissues and in their peritumoral counterparts from biopsy specimens of 41 HCC patients.23229173
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsHuman hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC.23229173
CarcinogenesisEpigenetic AlterationsPolymorphisms in 3 untranslated region (UTR) of cancer-related genes might affect their regulation by microRNAs (miRNAs) and thereby contribute to carcinogenesis.23232114
Diffuse Large B-Cell LymphomaEpigenetic AlterationsFurther investigations may also help to elucidate the biological role of microRNA-200c in DLBCL.23232598
Breast Carcinoma, NRAS geneEpigenetic AlterationsmiR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1.23233531
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are a class of small noncoding RNAs whose expression changes are associated with cancer development and invasion.23238818
Breast Carcinoma, MetastasisEpigenetic AlterationsThe level of circulating miRNA-10b and miRNA-373 in detecting lymph node metastasis of breast cancer: potential biomarkers.23238818
Breast CarcinomaEpigenetic AlterationsOur data suggest that circulating miRNA-10b and miRNA-373 are potential biomarkers for detecting the lymph node status of breast cancer.23238818
Breast CarcinomaEpigenetic AlterationsA miRNA binding site single-nucleotide polymorphism in the 3-UTR region of the IL23R gene is associated with breast cancer.23239971
Breast CarcinomaEpigenetic AlterationsOur results suggest that a miRNA binding site SNP in the 3-UTR region of the IL23R gene may be associated with the risk of breast cancer and contribute to the early development of breast cancer in Chinese women.23239971
NeoplasmsEpigenetic AlterationsTo date, most epigenetic studies have focused on somatic methylation events occurring within solid tumors; less is known of the contributions of peripheral blood cell (PBC) methylation to processes such as aging and tumorigenesis.23240038
Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA-27a (miR-27a) is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10.23240057
InflammationEpigenetic AlterationsEpigenetic modification, oxidative stress, and inflammation play an important role in the pathogenesis of the disease.23242124
Diastolic dysfunctionEpigenetic AlterationsCirculating miRNA as novel markers for diastolic dysfunction.23247724
Cardiovascular DiseasesEpigenetic AlterationsThe diagnostic potential of miRNA detection in human plasma for cardiovascular disorders is beginning to be recognized as important.23247724
Dilated Cardiomyopathy Pathway, Diastolic dysfunction, Congestive heart failureEpigenetic AlterationsThe presence of these miRNAs was tested in stable patients with isolated DD, patients with stable compensated dilated cardiomyopathy (DCM-systolic plus diastolic dysfunction) and those with decompensated congestive heart failure secondary to dilated cardiomyopathy (DCM-CHF-systolic plus diastolic dysfunction).23247724
Diastolic dysfunctionEpigenetic AlterationsWe identified new circulating miRNAs (miR-454, miR-500, miR-1246, miR-142-3p) which showed distinct patterns of expression in patients with diastolic dysfunction.23247724
Diastolic dysfunctionEpigenetic AlterationsWe therefore propose that these circulating miRNAs may serve as novel biomarkers for diastolic dysfunction because in all of these patients the only common factor was diastolic dysfunction.23247724
Breast CarcinomaEpigenetic AlterationsIn addition, identifying patients with KEAP1 epigenetic abnormalities may contribute to disease progression prediction in breast cancer patients.23249627
Fibrosis AssessmentEpigenetic AlterationsCorrelation of epigenetic change and identification of risk factors for oral submucous fibrosis.23250779
InflammationEpigenetic AlterationsThe hypermethylation of E-cadherin and cyclooxygenase 2 (COX-2) in chronic inflammation may demonstrate a mild lesion/mutation at epigenetic levels.23250779
Inflammation, Primary malignant neoplasmEpigenetic AlterationsThe epigenetic changes presented in patients with chronic inflammation might demonstrate an irreversible destruction in the tissues or organs similar to the effects of cancer.23250779
Diabetes MellitusEpigenetic AlterationsFurthermore, exposure of healthy CD34(pos)-PCs to high glucose reproduced the transcriptional changes induced by diabetes mellitus, with this effect being reversed by forced expression of microRNA-155.23250986
Allergic sensitizationEpigenetic AlterationsAllergen sensitization is associated with increased DNA methylation in older men.23257623
Asthma Pathway, Allergic sensitizationEpigenetic AlterationsThese data suggest that increased DNA methylation of repetitive elements may be associated with allergen sensitization but does not appear to be associated with asthma.23257623
Hypersensitivity, Asthma PathwayEpigenetic AlterationsVariation in epigenetic modifications, arising from either environmental exposures or internal physiological changes, can influence gene expression and may ultimately contribute to complex diseases such as asthma and allergies.23257623
Asthma PathwayEpigenetic AlterationsPrevious studies have suggested that the pathogenesis of asthma may be affected by epigenetic regulation.23257708
Precursor T cell lymphoblastic leukemia/lymphoblastic lymphomaEpigenetic AlterationsMicro-RNA-16 expression in paraffin-embedded specimen correlates with overall survival of T-lymphoblastic lymphoma/leukemia.23260326
Precursor T cell lymphoblastic leukemia/lymphoblastic lymphomaEpigenetic AlterationsTo our knowledge, we provide here the first evidence that the expression of a single micro-RNA, miR-16, is associated with clinical outcome of patients with T-lymphoblastic lymphoma/leukemia.23260326
NeoplasmsEpigenetic AlterationsRecently, specific micro-RNAs have emerged as potential biomarkers for the diagnosis and prognosis of various types of tumor.23260326
Epilepsy, Temporal LobeEpigenetic AlterationsRecently, several miRNAs have been found to be differentially expressed in animal models of TLE.23262343
Thrombocytosis, Polycythemia VeraEpigenetic AlterationsMicroRNA deregulation in polycythemia vera and essential thrombocythemia patients.23265742
ErythrocytosisEpigenetic AlterationsSince erythrocytosis is the only feature that distinguishes PV from ET, we also compared specific miRNA expression in the nucleated erythroid cells directly descended from the early erythroid progenitor cells of PV and ET patients.23265742
Erythrocytosis, ThrombocytosisEpigenetic AlterationsThe results of our study also suggest that deregulated miRNAs may represent an important mechanism by which the PV erythrocytosis and ET thrombocytosis phenotypes are determined.23265742
Primary malignant neoplasmEpigenetic AlterationsThe miRNA-regulating enzymes Dicer and Drosha exhibit aberrant expression in several cancer types.23266047
Prostate Cancer PathwayEpigenetic AlterationsDevelopment and clinical validation of a real-time PCR assay for PITX2 DNA methylation to predict prostate-specific antigen recurrence in prostate cancer patients following radical prostatectomy.23266319
Prostate Cancer PathwayEpigenetic AlterationsPITX2 DNA methylation is a strong prognostic biomarker in prostate cancer.23266319
Malignant neoplasm of urinary bladderEpigenetic AlterationsCirculating microRNAs in serum: novel biomarkers for patients with bladder cancer?23266581
Stomach CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) such as miR-17-5p, miR-21, miR-106a and miR-106b are reported to be highly expressed in gastric carcinoma (GC) tissues.23267156
NeoplasmsEpigenetic AlterationsRecently, we reported that these miRNAs were consistently detectable in plasma and reflected tumor dynamics of GC.23267156
Clinical CoordinatorEpigenetic AlterationsPatients with CRC or AAs had plasma miRNA expression profiles that differed significantly from those of controls.23267864
Clinical CoordinatorEpigenetic AlterationsPatients with CRC have significantly different patterns of miRNA expression than healthy individuals.23267864
Primary malignant neoplasmEpigenetic AlterationsCirculating microRNAs (miRNAs/miRs) might be used as biomarkers for the diagnosis of cancer and other diseases.23267864
Clinical CoordinatorEpigenetic AlterationsWe selected a group of 13 miRNAs for validation in an independent cohort of patients; 6 (miR18a, miR19a, miR19b, miR15b, miR29a, and miR335) were confirmed to be significantly up-regulated in patients with CRC, differentiating patients with CRC from controls with area under the receiver operating characteristic curve values ranging from 0.80 (95% confidence interval [CI], 0.71-0.89) to 0.70 (95% CI, 0.59-0.80).23267864
Colorectal Cancer PathwayEpigenetic AlterationsDifferent patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer.23271133
NeoplasmsEpigenetic AlterationsThese findings suggest that miR-149 suppresses tumor cell mobility, and that the pre-mir-149 polymorphism may affect the processing of miR-149, resulting in a change in the abundance of the mature form miRNA, which, in turn, modulates tumor progression and patient survival.23272122
Malignant Neoplasms, Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in modulating the neoplastic process of cancers including head and neck squamous cell carcinoma (HNSCC).23272122
Carcinoma, Ovarian EpithelialEpigenetic AlterationsElevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer.23272653
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs are stable in the circulation and may have utility as biomarkers of malignancy.23272653
Tuberculosis, PulmonaryEpigenetic AlterationsAltered serum microRNAs as biomarkers for the early diagnosis of pulmonary tuberculosis infection.23272999
Tuberculosis, PulmonaryEpigenetic AlterationsThe Low-Density Array data showed that 97 miRNAs were differentially expressed in pulmonary TB patient sera compared with healthy controls (90 up-regulated and 7 down-regulated).23272999
Lymphoma, FollicularEpigenetic AlterationsPrognostic significance of epigenetic inactivation of p16, p15, MGMT and DAPK genes in follicular lymphoma.23275143
Glioblastoma Multiforme PathwayEpigenetic AlterationsFurther research is warranted on the SWI/SNF complex genes and epigenetic mechanisms more generally in the development of glioma in adults.23276717
Clinical CoordinatorEpigenetic AlterationsA significant association with increased disease free survival was confirmed for miR-362-3p in a second independent cohort of 43 CRC patients, using single TaqMan((r)) microRNA assays.23280316
Colorectal Cancer PathwayEpigenetic AlterationsMiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer.23280316
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are aberrantly expressed in cancers and appear to have both diagnostic and prognostic significance.23280316
NeoplasmsEpigenetic AlterationsFour miRNAs (miR-362-3p, miR-570, miR-148 a* and miR-944) were expressed at a higher level in tumors from patients with no recurrence (p<0.015), compared with tumors from patients with recurrence.23280316
CarcinomaEpigenetic AlterationsEpigenetic changes in Basal Cell Carcinoma affect SHH and WNT signaling components.23284750
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsEpigenetic alterations such as promoter hypermethylation silence tumor suppressor genes (TSG) in several malignancies.23284750
Ulcerative ColitisEpigenetic AlterationsUp-regulation of microRNA-126 may contribute to pathogenesis of ulcerative colitis via regulating NF-kappaB inhibitor IkBa.23285182
Ulcerative ColitisEpigenetic AlterationsAltered expression of miRNAs has recently demonstrated association with human ulcerative colitis (UC).23285182
SERPINB3 wt Allele, Primary malignant neoplasmEpigenetic AlterationsAlthough OSCC seems as much an epigenetic as a genetic disease, the translational potential of cancer epigenetics has yet to be fully exploited.23287992
Squamous cell carcinomaEpigenetic AlterationsThe epigenetic landscape of oral squamous cell carcinoma.23287992
SERPINB3 wt AlleleEpigenetic AlterationsEpigenetic deregulation of NOTCH4 signalling in OSCC was also observed, as part of a possible methylation signature for recurrence, with parallels to recently discovered NOTCH mutations in HNSCC.23287992
SERPINB3 wt AlleleEpigenetic AlterationsThis data points to the application of epigenetic biomarkers and targets available to further the development of therapy in OSCC.23287992
Inflammatory Bowel DiseasesEpigenetic AlterationsOverexpression of microRNAs-155 and 21 targeting mismatch repair proteins in inflammatory bowel diseases.23288924
ibudilastEpigenetic AlterationsHere, we hypothesize that overexpression of miR-155 and miR-21, two inflammation-related microRNAs that target core MMR proteins, may constitute a pre-neoplastic event for the development of MSI IBD CRCs.23288924
ibudilast, Primary malignant neoplasmEpigenetic AlterationsThese results show a strong deregulation of both MMR-targeting microRNAs in IBD subjects with or without cancer.23288924
Stomach CarcinomaEpigenetic AlterationsLoss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancer.23291975
Stomach CarcinomaEpigenetic AlterationsBisulfate sequencing showed that TFF1 expression is strongly dependent on DNA methylation in both gastric cancer cells and tissues.23291975
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsTFF1 expression is silenced by DNA methylation and is associated with tumor invasion and a poor survival in gastric cancer patients.23291975
Helicobacter Pylori-Related Gastric AdenocarcinomaEpigenetic AlterationsAltered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis.23292007
Carcinogenesis, Helicobacter pylori, InflammationEpigenetic AlterationsChronic inflammation triggered by Helicobacter pylori causes altered DNA methylation in stomach mucosae, which is deeply involved in gastric carcinogenesis.23292007
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAberrant expression as well as genetic and epigenetic alterations of numerous genes involved in different pathways of apoptosis regulation has been described in CLL.23292833
Glioblastoma Multiforme PathwayEpigenetic AlterationsExpression and clinical significance of microRNA-326 in human glioma miR-326 expression in glioma.23292865
NeoplasmsEpigenetic AlterationsAs a suppressor of Hedgehog signaling pathway, microRNA-326 (miR-326) has been demonstrated to control the development of cerebellar neuronal progenitor and tumor cells.23292865
Glioblastoma Multiforme PathwayEpigenetic AlterationsCorrelation of microRNA-372 upregulation with poor prognosis in human glioma.23298385
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-372 (miR-372) acts as either an oncogenic miRNA or an anti-oncomiR in various human malignancies.23298385
Malignant Neoplasms, Glioma, NeoplasmsEpigenetic AlterationsTaken together, these data offer the convincing evidence for the first time that miR-372 may act as an oncogenic miRNA in gliomas and represent a potential regulator of aggressive development and a candidate prognostic marker for this malignancy, especially for advanced tumors with high pathological grades.23298385
Hollings Cancer CenterEpigenetic AlterationsOur data suggest potential molecular mechanisms underpinning miRNA-controlled HCC recurrence, and support the notion that miRNA expression signature and miRNA-based therapy can be useful tools for a better diagnosis and treatment stratification of this disease.23299437
Liver carcinomaEpigenetic AlterationsIdentification of recurrence related microRNAs in hepatocellular carcinoma after surgical resection.23299437
Primary malignant neoplasm, Hollings Cancer CenterEpigenetic AlterationsMoreover, functional annotation of predicted target genes of these recurrent HCC-related miRNAs indicates that multiple biological pathways (i.e., focal adhesion pathway, cancer-related pathways and mitogen-activated protein kinase (MAPK) signaling) that are all critical for cancer development and progression, may participate in the recurrence of HCC.23299437
Primary malignant neoplasmEpigenetic AlterationsCancer subjects had significantly lower PBMCs-DNA methylation than controls [4.39 (95% confidence intervals (CI), 4.25-4.53) vs. 5.13 (95% CI, 5.03-5.21) %mCyt/(mCyt+Cyt); P < 0.0001].23300023
Primary malignant neoplasmEpigenetic AlterationsA DNA methylation threshold of 4.74% clearly categorized patients with cancer from controls so that those with DNA methylation less than 4.74% showed an increased prevalence of cancer than those with higher levels (91.5% vs. 19%; P < 0.001).23300023
Primary malignant neoplasmEpigenetic AlterationsSubjects with cancer at follow-up had, already at enrollment, reduced DNA methylation as compared with controls [4.34 (95% CI, 4.24-4.51) vs. 5.08 (95% CI, 5.05-5.22) %mCyt/(mCyt+Cyt); P < 0.0001].23300023
Primary malignant neoplasmEpigenetic AlterationsMoreover, MTHFR677C>T genotype and folate interact for determining DNA methylation, so that MTHFR677TT carriers with low folate had the lowest DNA methylation and concordantly showed a higher prevalence of cancer history (OR, 7.04; 95% CI, 1.52-32.63; P = 0.013).23300023
Primary malignant neoplasmEpigenetic AlterationsGenomic PBMCs-DNA methylation may be a useful epigenetic biomarker for early detection and cancer risk estimation.23300023
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsSpliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome.23300180
Antilymphocyte SerumEpigenetic AlterationsAlterations in epigenetic modifications are likely to play a role in disease onset and progression in ALS, as aberrant epigenetic patterns may be acquired throughout life.23300739
Breast Carcinoma, NeoplasmsEpigenetic AlterationsProfiling results showed 8 miRNAs were concordantly up-regulated and 1 miRNA was concordantly down-regulated in both plasma and tumor tissue of breast cancer patients.23301032
Breast CarcinomaEpigenetic AlterationsCirculating microRNAs as specific biomarkers for breast cancer detection.23301032
Colorectal Cancer PathwayEpigenetic AlterationsWe previously showed microRNAs (miRNAs) in plasma are potential biomarkers for colorectal cancer detection.23301032
Breast CarcinomaEpigenetic AlterationsThese results suggested that these circulating miRNAs could be a potential specific biomarker for breast cancer screening.23301032
Congestive heart failureEpigenetic AlterationsMicroRNA 210 as a biomarker for congestive heart failure.23302636
Stomach CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) play crucial roles during the occurrence and development of gastric cancer.23307240
Stomach CarcinomaEpigenetic AlterationsSeveral miRNAs in peripheral blood have been used as biomarkers of gastric cancer.23307240
Primary malignant neoplasmEpigenetic AlterationsHowever, most of these miRNAs are shared by several types of cancer.23307240
Stomach CarcinomaEpigenetic AlterationsIn summary, our results suggest that gastric juice miR-129-1-3p and miR-129-2-3p are potential biomarkers for the screening gastric cancer, and the detection of gastric juice miRNAs is a convenient non-invasion method for the diagnosis of gastric cancer.23307240
Impaired cognition, Fetal Measurements DomainEpigenetic AlterationsMethylation of the fragile X-related epigenetic element 2 (FREE2) located on the exon 1/intron 1 boundary of the FMR1 gene is related to FMRP expression and cognitive impairment in full mutation (FM; CGG>200) individuals.23307923
BehaviorEpigenetic AlterationsMicroRNAs (miRNAs) regulate cancer cell behavior and may be attractive biomarkers for prognosis and prediction of response.23308047
Fibrosis AssessmentEpigenetic AlterationsMicroRNA signature at the time of clinical HCV recurrence associates with aggressive fibrosis progression post-liver transplantation.23312020
Aortic Aneurysm, AbdominalEpigenetic AlterationsTissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm.23316282
Arteriosclerosis, Coronary ArteriosclerosisEpigenetic AlterationsMicroRNAs play a fundamental role in atherosclerosis, and atherosclerotic coronary artery disease is characterized by tissue- and plasma-specific microRNA signatures.23316282
SF3B1 wt Allele, Myeloid neoplasm, Myeloproliferative disease, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsGenomic studies in chronic myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and MPN/MDS, have identified common mutations in genes encoding signaling, epigenetic, transcription, and splicing factors.23319568
OsteosarcomaEpigenetic AlterationsIdentification of serum microRNA-21 as a biomarker for chemosensitivity and prognosis in human osteosarcoma.23321165
Secondary malignant neoplasm of female breastEpigenetic AlterationsMicroRNA-374a activates Wnt/b-catenin signaling to promote breast cancer metastasis.23321667
Breast CarcinomaEpigenetic AlterationsHere we report that Wnt/b-catenin signaling is hyperactivated in metastatic breast cancer cells that express microRNA 374a (miR-374a).23321667
CocarcinogenesisEpigenetic AlterationsMicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis.23322197
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA, miR)-18a is a member of the miR-17-92 cluster, an important locus that is markedly overexpressed in several cancers and associated with cancer development and progression.23322197
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsMicroRNA-34a promotes cardiomyocyte apoptosis post myocardial infarction through down-regulating aldehyde dehydrogenase 2.23323620
Primary malignant neoplasmEpigenetic AlterationsGene silencing through CpG island hypermethylation is a major epigenetic mechanism involved in cancer development.23324576
Colorectal Cancer PathwayEpigenetic AlterationsOur results suggest that epigenetic down-regulation of TMEM25 is cancer-related; we thus suggest that TMEM25 hypermethylation might play a significant role in altering expression of this gene in colorectal cancer.23324576
Hypertensive disease, Hypertensive (finding)Epigenetic AlterationsThe identification of a difference in a blood leukocyte DNA methylation site between hypertensive cases and normotensive controls suggests that changes in DNA methylation may play an important role in the pathogenesis of hypertension.23325143
Stomach CarcinomaEpigenetic AlterationsSix of them were randomly selected and miRNA microarray was applied to study the miRNA expression profiles of gastric cancer.23328512
Stomach CarcinomaEpigenetic AlterationsCompared with normal gastric tissues, 7 miRNA were significantly up-regulated and 9 miRNA significantly down-regulated for over 2 folds in gastric cancer tissues (P < 0.05).23328512
Stomach CarcinomaEpigenetic AlterationsSpecial miRNA expression profiles of gastric cancer are found.23328512
Intestinal Neuroendocrine TumorEpigenetic AlterationsGlobal microRNA profiling of well-differentiated small intestinal neuroendocrine tumors.23328977
NeoplasmsEpigenetic AlterationsMoreover, we characterized nine miRNAs, five (miR-96, -182, -183, -196a and -200a), which are upregulated during tumor progression, whereas four (miR-31, -129-5p, -133a and -215) are downregulated.23328977
Pancreatic carcinomaEpigenetic AlterationsUp-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherin.23331011
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate gene expression, thereby affecting crucial processes in cancer development.23334650
Breast CarcinomaEpigenetic AlterationsSerum circulating microRNA profiling for identification of potential breast cancer biomarkers.23334650
Breast CarcinomaEpigenetic AlterationsWe performed miRNA profiling on serum from breast cancer patients, followed by construction of ROC (Receiver Operating Characteristic) curves to determine the sensitivity and specificity of the assay.23334650
Breast CarcinomaEpigenetic AlterationsmiRNA profiling in serum has potential as a novel method for breast cancer detection in the Mexican population.23334650
Primary malignant neoplasmEpigenetic AlterationsmiRNAs offer great potential as biomarkers for cancer detection because of their remarkable stability in blood and their characteristic expression in different diseases.23334650
Breast CarcinomaEpigenetic AlterationsWe found that seven miRNAs (miR-10b, miR-21, miR-125b, miR-145, miR-155 miR-191 and miR-382) had different expression patterns in serum of breast cancer patients compared to healthy controls.23334650
Admitting diagnosisEpigenetic AlterationsRecent studies suggest epigenetic influences on gene expression in AD, as DNA methylation levels influence protein and mRNA expression in postmortem AD brain.23336521
ArteriosclerosisEpigenetic AlterationsRecent evidence supports a role for miRNAs in cardiovascular pathophysiology and atherosclerosis development.23339529
Dilated Cardiomyopathy PathwayEpigenetic AlterationsAlterations in cardiac DNA methylation in human dilated cardiomyopathy.23341106
methylene chlorideEpigenetic AlterationsAberrant DNA methylation in DCM patients was associated with significant changes in LY75 and ADORA2A mRNA expression, but not in ERBB3 and HOXB13.23341106
methylene chlorideEpigenetic AlterationsHence, disease mechanisms must exist that modify the occurrence and progression of DCM, either by genetic or epigenetic factors that may interact with environmental stimuli.23341106
AdenocarcinomaEpigenetic AlterationsFurthermore, we identified a three-miRNA plasma signature (high miR-155-5p, high miR-223-3p, and low miR-126-3p) that significantly associated with a higher risk for progression in adenocarcinoma patients.23342174
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn conclusion, we identified two plasma miRNA expression profiles that may be useful for predicting the outcome of patients with resectable NSCLC.23342174
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs), a group of small, noncoding RNAs, can be isolated from blood serum samples and have demonstrated utility as biomarkers in multiple cancer types.23342275
Primary malignant neoplasmEpigenetic AlterationsCombining these serum miRNA profiles with other screening techniques could greatly improve the sensitivity in oral cancer detection.23342275
Malignant neoplasm of mouthEpigenetic AlterationsFive of these miRNAs (miR-16, let-7b, miR-338-3p, miR-223, and miR-29a) yielded an area under the ROC curve (AUC) >0.8, suggesting utility as noninvasive biomarkers for detection of oral cancer or high-grade lesions.23342275
NeoplasmsEpigenetic AlterationsIn general, the overall tumor miRNA expression was downregulated in our cohort compared with normal tissues.23349018
Squamous cell carcinoma, AdenocarcinomaEpigenetic AlterationsExpression levels of hsa-let-7a (P = 0.005) and miR-16 (P = 0.003) miRNA were significantly higher in squamous cell carcinoma than in adenocarcinoma samples.23349018
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification.23349018
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLevels of DICER1, DROSHA and five different miRNAs were measured in NSCLC specimens (N = 115) by qRT-PCR assay and correlated with clinical outcomes.23349018
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn addition, differential expression of miRNAs, such as hsa-let-7a and miR-16 may be helpful tools in the histologic subclassification of NSCLC.23349018
MeningiomaEpigenetic AlterationsDNA methylation in the malignant transformation of meningiomas.23349797
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsClustering analysis readily separates malignant from atypical and benign tumors, implicating that DNA methylation patterns may serve as diagnostic biomarkers for malignancy.23349797
Meningioma, Malignant MeningiomaEpigenetic AlterationsMost genes with hypermethylated CpG islands at promoters are suppressed in malignant and benign meningiomas, suggesting the switching of gene silencing machinery from PRC binding to DNA methylation in malignant meningiomas.23349797
S100A4 protein, human, Malignant MeningiomaEpigenetic AlterationsIn summary, our results suggest that malignant meningiomas have distinct DNA methylation patterns compared to their benign and atypical counterparts, and that the differentially methylated genes may serve as diagnostic biomarkers or candidate causal genes for malignant transformation.23349797
Meningioma, S100A4 protein, human, Malignant MeningiomaEpigenetic AlterationsDespite previous studies on benign and atypical meningiomas, the key molecular pathways involved in malignant transformation remain to be determined, as does the extent of epigenetic alteration in malignant meningiomas.23349797
Malignant neoplasm of stomachEpigenetic AlterationsmiRCURY LNA Arrays (v.16.0; Exiqon, Vedbaek, Denmark) were used to screen miRNAs in 17 gastric cancers.23351547
Stomach CarcinomaEpigenetic AlterationsIn gastric cancer, 49 miRNAs were overexpressed by 2.0-fold or greater, and 39 miRNAs were down-regulated by 1.5-fold or greater, whereas miR-10b was up-regulated by 2.98-fold.23351547
Prostate Cancer Pathway, ObesityEpigenetic AlterationsRecent evidence shows that certain microRNAs (miRNAs) play a role in both obesity and prostate cancer recurrence, but the association between the expression of these miRNAs and obesity in prostate cancer recurrence is unknown.23353719
Malignant tumor of colonEpigenetic AlterationsClinical significance of microRNA-93 downregulation in human colon cancer.23354160
Malignant tumor of colonEpigenetic AlterationsMicroRNA-93 (miR-93) has been shown to suppress proliferation and colony formation of colon cancer stem cells.23354160
Primary malignant neoplasmEpigenetic AlterationsCirculating cell-free microRNAs (miRNAs) are potential cancer biomarkers.23354517
Metastatic Neoplasm to the BladderEpigenetic AlterationsLong non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression.23354591
Primary malignant neoplasmEpigenetic AlterationsAfter adjusting for cancer site, stage, age, gender, alcohol consumption, and smoking status, HPV status was found to be a significant predictor for DNA methylation at an additional 11 genes, including CASP8 and SYBL1.23358896
Malignant NeoplasmsEpigenetic AlterationsEpigenetic changes are an important mechanism in carcinogenic progression, but how these changes differ between viral- and chemical-induced cancers remains unknown.23358896
CarcinogenesisEpigenetic AlterationsThese findings provide insight into the epigenetic regulation of viral vs. chemical carcinogenesis and could provide novel targets for development of individualized therapeutic and prevention regimens based on environmental exposures.23358896
Stage I Esophageal Squamous Cell Carcinoma AJCC v7Epigenetic AlterationsSerum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma.23361059
Stage I Esophageal Squamous Cell Carcinoma AJCC v7, Squamous cell carcinoma of esophagusEpigenetic AlterationsWe performed an miRNA array using serum samples obtained from oesophageal squamous cell carcinoma (ESCC) patients or healthy controls.23361059
Squamous cell carcinoma of esophagusEpigenetic AlterationsThese data support our contention that serum miR-1246 has strong potential as a novel diagnostic and prognostic biomarker in ESCC, and its releasing mechanism is selective and independent of tissue miRNA abundance.23361059
Primary malignant neoplasmEpigenetic AlterationsRecent studies have demonstrated that microRNAs (miRNAs) are stably detectable in blood and can serve as useful biomarkers for cancer.23361059
EndometriosisEpigenetic AlterationsWe identified three distinct miRNA signatures with reliable differential expression between healthy individuals, patients with endometriosis, and patients with EAOC.23362326
EndometriosisEpigenetic AlterationsOur study reports for the first time that distinct plasma miRNA expression patterns may serve as highly specific and sensitive diagnostic biomarkers to discriminate between healthy, endometriosis, and EAOC cases.23362326
Endometriosis, ovarian neoplasmEpigenetic AlterationsPlasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer.23362326
Endometriosis, ovarian neoplasmEpigenetic AlterationsWe aimed to identify plasma miRNAs that can be used to differentiate patients with endometriosis and ovarian cancer from healthy individuals.23362326
EndometriosisEpigenetic AlterationsIn the first stage, using global profiling of more than 1,000 miRNAs via reverse transcriptase quantitative PCR (RT-qPCR) in a 20-patient initial screening cohort, we identified 23 candidate miRNAs, which are differentially expressed between healthy controls (n = 6), patients with endometriosis (n = 7), and patients with EAOC (n = 7) based on the fold changes.23362326
Endometriosis, ovarian neoplasmEpigenetic AlterationsIn the second stage, the 23 miRNAs were further tested in an expanded cohort (n = 88) of healthy individuals (n = 20), endometriosis (n = 33), EAOC (n = 14), and serous ovarian cancer cases (SOC; n = 21, included as controls).23362326
Diffuse Large B-Cell LymphomaEpigenetic AlterationsAgilent Human miRNA Microarray 16.0 was used to select the miRNAs on paraffin-embedded tissues of 24 DLBCL cases.23363792
Bladder NeoplasmEpigenetic AlterationsBladder tumors in patients younger than 20 years show a low incidence of the genetic and epigenetic aberrations typically found in older patients.23369722
Malignant NeoplasmsEpigenetic AlterationsOne of the most common epigenetic aberrations in human malignancies is DNA hypermethylation.23369722
Barrett EsophagusEpigenetic AlterationsDiscovery and validation of Barretts esophagus microRNA transcriptome by next generation sequencing.23372692
Gastroesophageal reflux diseaseEpigenetic AlterationsNGS-identified miRNA were validated using qRT-PCR in an independent group of 40 GERD and 27 BE patients.23372692
ClusterEpigenetic AlterationsCluster analysis found similarly regulated (up or down) miRNA to share common targets suggesting coordination between miRNA.23372692
Gastroesophageal reflux diseaseEpigenetic AlterationsDifferentially expressed miRNA between BE and GERD have been further validated.23372692
Secondary malignant neoplasm of liver, Colorectal Neoplasms, MetastasisEpigenetic AlterationsWe compared miRNA expression between primary colorectal tumors and liver metastasis to identify those involved in the process of metastasis.23373973
Secondary malignant neoplasm of liver, Primary NeoplasmEpigenetic AlterationsThe most abundant miRNA in liver metastasis compared with primary tumors was miR-122.23373973
Malignant Neoplasms, Secondary malignant neoplasm of liverEpigenetic AlterationsMicroRNAs have been shown to be involved in the development of many cancers, but little is known about their role in the process of colorectal liver metastasis.23373973
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsDysregulation of microRNA-100 (miR-100) has been reported to be involved in tumorigenesis and tumor progression of several cancer types.23378187
Non-Small Cell Lung CarcinomaEpigenetic AlterationsGiven the density of single-nucleotide polymorphisms (SNP) in the human genome and the sensitivity of single-nucleotide changes in microRNA (miRNA) functionality and processing, we asked whether polymorphisms within miRNA processing pathways and binding sites may influence non-small cell lung cancer (NSCLC) patients prognosis.23378343
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese results indicate that miRNA-related polymorphisms may be associated with NSCLC patients clinical outcomes through altered miRNA regulation of target genes.23378343
NeoplasmsEpigenetic AlterationsMicroRNAs are small molecules involved in several cellular processes, and their expression is altered in the vast majority of tumors.23383149
Liver damage, Hepatitis C, ChronicEpigenetic AlterationsSensitive detection of hepatocellular injury in chronic hepatitis C patients with circulating hepatocyte-derived microRNA-122.23383654
Transitional cell carcinoma of bladderEpigenetic AlterationsPredicting progression of bladder urothelial carcinoma using microRNA expression.23387295
NeoplasmsEpigenetic AlterationsFor 19 samples, microdissection was performed to compare microRNA expression between the tumour and surrounding tissue.23387295
NeoplasmsEpigenetic AlterationsThe microRNA profile of tumours invading the bladder muscle was more similar to that of NMI tumours from patients who later progressed, than to that of the same-stage NMI tumours from patients who did not later progress.23387295
NeoplasmsEpigenetic AlterationsThe expression level of one microRNA, miR-29c*, was significantly under-expressed in tumours that progressed and could be used to stratify patients with T1 disease into risk groups.23387295
NeoplasmsEpigenetic AlterationsTumour progression was associated with altered levels of microRNAs.23387295
NMI protein, human, Carcinoma of bladderEpigenetic AlterationsTo identify microRNAs that could be useful as prognostic markers for non-muscle-invasive (NMI) bladder carcinoma.23387295
NeoplasmsEpigenetic AlterationsMicroRNAs that were found to be unrelated to the tumour itself were excluded as potential prognostic markers.23387295
Carcinoma, Transitional CellEpigenetic AlterationsMicroRNAs can be useful biomarkers for prognosis in patients with urothelial carcinoma.23387295
Breast CarcinomaEpigenetic AlterationsDown-regulation of miRNA-30a in human plasma is a novel marker for breast cancer.23389917
NeoplasmsEpigenetic AlterationsAnd we compared the diagnostic value of plasma miRNA-30a with conventional circulating tumor markers CA153 and CEA.23389917
Triple-Negative Breast Cancer FindingEpigenetic AlterationsThe status of ER and triple-negative BC was significantly associated with miRNA-30a level (P = 0.007 and P = 0.005, respectively).23389917
Prostate Cancer Pathway, Malignant neoplasm of prostateEpigenetic AlterationsCharacterization of transcriptional changes in ERG rearrangement-positive prostate cancer identifies the regulation of metabolic sensors such as neuropeptide Y. ERG gene rearrangements are found in about one half of all prostate cancers.23390522
Prostate Cancer PathwayEpigenetic AlterationsTranscriptional changes between prostate cancer and non-cancerous prostate, as well as ERG rearrangement-positive (ERG+) and ERG rearrangement-negative (ERG-) prostate cancer, were analyzed.23390522
Prostate Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsIn summary, we found robust population-independent transcriptional changes in prostate cancer and first signs of ERG rearrangements inducing metabolic changes in cancer cells by activating major metabolic signaling molecules like NPY.23390522
Malignant tumor of colonEpigenetic AlterationsFunctional polymorphism in the MicroRNA-367 binding site as a prognostic factor for colonic cancer.23393343
Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAs microRNAs play important roles in cancer development and progression by regulating the expressions of oncogenes and tumor suppressor genes though interacting with the 3 untranslated region (UTR) of target genes, we aimed to evaluate the association between genetic variants of miRNAs and their binding sites and prognosis in patients with colorectal cancer (CRC).23393343
Multiple MyelomaEpigenetic AlterationsImpact of global and gene-specific DNA methylation pattern in relapsed multiple myeloma patients treated with bortezomib.23395385
Neoplasms, Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-153 is tumor suppressive in glioblastoma stem cells.23397238
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAccumulating data indicate that some microRNAs (miRNAs or miRs) can function as tumor suppressors or oncogenes and as such are important in cancer development.23397547
Liver carcinomaEpigenetic AlterationsDownregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma.23398123
NeoplasmsEpigenetic AlterationsGenetic alterations and deregulation of the miRNA biogenesis pathway components have been reported in human tumors.23398123
CarcinogenesisEpigenetic AlterationsTissue-specific deletion of the Dicer gene, which encodes an essential miRNA processing enzyme, promotes carcinogenesis in animal models.23398123
Primary malignant neoplasmEpigenetic AlterationsThese features indicate that aberrant miRNA biogenesis components are directly associated with cancer.23398123
Hollings Cancer CenterEpigenetic AlterationsTrimethylation of histone H3 lysine 27 in the promoters is implicated in the deregulation of these miRNA-biogenesis-related genes in non-HBV genome integrated HCC cell lines.23398123
Hollings Cancer CenterEpigenetic AlterationsIn conclusion, deregulation of the miRNA biogenesis pathway components is frequently observed in non-viral-associated HCC and is linked to etiological risk factors and poor prognosis.23398123
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsLong noncoding RNAs have been shown to have important regulatory roles in cancer biology, and long noncoding RNA 19 (H19) is essential for human tumor growth.23399020
Ductal Carcinoma, Noninfiltrating Intraductal Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-132 is frequently down-regulated in ductal carcinoma in situ (DCIS) of breast and acts as a tumor suppressor by inhibiting cell proliferation.23399321
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsAltered miRNA expression could also contribute to the origination of cancer, including breast cancer.23399321
Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsHere, by using miRNA microarray and real time PCR, we analyzed the miRNA expression profile in 21 DCIS and the corresponding normal tissues.23399321
Lupus Erythematosus, SystemicEpigenetic AlterationsThese findings highlight possible dysregulated pathways in SLE and suggest that circulating miRNA patterns distinguish SLE from other immunoinflammatory phenotypes.23401079
Stomach CarcinomaEpigenetic AlterationsAssessment of SOX17 DNA methylation in cell free DNA from patients with operable gastric cancer.23403728
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsDNA methylation represents one of the most common epigenetic changes in human cancer providing important information regarding carcinogenesis.23403728
Hematologic NeoplasmsEpigenetic AlterationsEpigenetic inactivation of the MIR129-2 in hematological malignancies.23406679
NeoplasmsEpigenetic AlterationsMIR129-2 has been shown to be a tumor suppressor microRNA hypermethylated in epithelial cancers.23406679
Myeloid neoplasm, NeoplasmsEpigenetic AlterationsMIR129-2 is a tumor suppressive microRNA frequently methylated in lymphoid but not myeloid malignancies, leading to reversible MIR129-2 silencing.23406679
Malignant neoplasm of urinary bladder, Aggressive behaviorEpigenetic AlterationsDecreased expression of microRNA-31 associates with aggressive tumor progression and poor prognosis in patients with bladder cancer.23408039
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-31 (miR-31) has different expression patterns in various human cancers.23408039
Primary malignant neoplasmEpigenetic AlterationsLeukocyte DNA methylation levels of selected imprinted genes may therefore serve as surrogate markers of DNA methylation in cancer tissue.23409079
Primary malignant neoplasmEpigenetic AlterationsThere is growing interest in identifying surrogate tissues to identify epimutations in cancer patients since primary target tissues are often difficult to obtain.23409079
AdenocarcinomaEpigenetic AlterationsmiRNA screening was done using qRT-PCR based low-density arrays (664 miRNAs) comparing adenocarcinoma patients (n=40) with and without recurrence 24 months after surgery.23410826
Adenocarcinoma, NeoplasmsEpigenetic AlterationsElevated miRNA levels were exclusively observed in the group of high-risk patient diagnosed for operable adenocarcinoma compared with benign diagnosis or advanced tumour disease.23410826
AdenocarcinomaEpigenetic AlterationsmiRNAs were also measured in advanced adenocarcinoma patients (n=29), and individuals with benign pulmonary diagnosis (n=21).23410826
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsGenome-wide profiling reveals epigenetic inactivation of the PU.1 pathway by histone H3 lysine 27 trimethylation in cytogenetically normal myelodysplastic syndrome.23411464
Glioblastoma MultiformeEpigenetic AlterationsVery little is known regarding correlation of micro RNA (miR)-106a with clinical outcomes of patients with glioblastoma multiforme (GBM).23416698
Carcinogenesis, Thyroid NeoplasmEpigenetic AlterationsAlterations in microRNA (miRNA) expression have been described in thyroid tumors, suggesting a role for miRNAs in thyroid carcinogenesis.23416953
Papillary thyroid carcinomaEpigenetic AlterationsExpressions of miRNAs in papillary thyroid carcinoma and their associations with the BRAFV600E mutation.23416953
F9 geneEpigenetic AlterationsmiRNAs differentially expressed between BRAF(V600E)-positive and -negative PTC tissues were then validated by real-time quantitative PCR on 69 PTC tissues and 69 paracancerous tissues.23416953
HypersensitivityEpigenetic AlterationsWe also focused on four genes with extensive hyper- or hypo-methylation in the muscle lineage (PAX3, TBX1, MYH7B/MIR499 and OBSCN) to compare DNA methylation, DNaseI hypersensitivity, histone modification, and CTCF binding profiles.23417056
NeoplasmsEpigenetic AlterationsFirst, we confirmed transcriptional alterations in genes involved in the oxidative stress induced by MAP17 expression in HeLa cervical tumor cells and found that Hela cells expressing MAP17 were more sensitive to therapies that induce ROS than were parental cells.23418532
Cervical Intraepithelial NeoplasiaEpigenetic AlterationsGenome-wide approaches have been used to identify DNA methylation marks associated with CIN persistence or progression.23418553
Cervical Intraepithelial NeoplasiaEpigenetic AlterationsHowever, associations between DNA methylation marks and CIN or ICC remain weak and inconsistent.23418553
Kidney Failure, ChronicEpigenetic AlterationsLikewise, microRNA expression profiling showed a broad overlap between ESRD and healthy donor MSCs.23419679
Acute myocardial infarctionEpigenetic AlterationsComparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction.23420161
Acute myocardial infarctionEpigenetic AlterationsRecent studies have shown that circulating microRNAs might be useful, novel biomarkers for the diagnosis of acute myocardial infarction.23420161
Acute myocardial infarctionEpigenetic AlterationsThe expression of the cardiac-specific miRNAs in acute myocardial infarction patients decreased to close to the baseline levels at the time of hospital discharge (all p>0.05).23420161
Acute myocardial infarction, Troponin T, Cardiac MuscleEpigenetic AlterationsOur results demonstrate that circulating miR-1, -133a, -208b, and -499 may be useful biomarkers in acute myocardial infarction patients but that these miRNAs are not superior to cardiac troponin T for the diagnosis of acute myocardial infarction.23420161
Glioblastoma MultiformeEpigenetic AlterationsComparison of microRNA expression levels between initial and recurrent glioblastoma specimens.23420397
Glioblastoma MultiformeEpigenetic AlterationsWe selected the following 7 microRNAs with potential relevance for glioblastoma pathobiology by means of a comprehensive literature search: microRNA-10b, microRNA-21, microRNA-181b, microRNA-181c, microRNA-195, microRNA-221 and microRNA-222.23420397
Epilepsy, Glioblastoma MultiformeEpigenetic AlterationsAll microRNAs showed detectable levels of expressions in glioblastoma group, whereas microRNA-10b was not detectable in epilepsy patients.23420397
Epilepsy, Glioblastoma MultiformeEpigenetic AlterationsMicroRNAs except microRNA-21 showed significantly higher levels in epilepsy patients when compared to the levels of first resection of glioblastoma.23420397
NeoplasmsEpigenetic AlterationsCox regression analyses showed no significant association of microRNA expression levels in the tumor tissue with progression free survival times.23420397
Glioblastoma MultiformeEpigenetic AlterationsExpression levels of microRNA-10b, microRNA-21, microRNA-181b, microRNA-181c, microRNA-195, microRNA-221 and microRNA-222 do not differ significantly between initial and recurrent glioblastoma.23420397
Aggressive behavior, Primary malignant neoplasm, Neoplasm MetastasisEpigenetic AlterationsMicroRNAs are small RNAs proposed o have important roles for cancer including proliferation, aggressiveness and metastases development.23420397
Glioblastoma MultiformeEpigenetic AlterationsThere exist only few data on the involvement of microRNAs in glioblastoma recurrence.23420397
Clinical Coordinator, NeoplasmsEpigenetic AlterationsObjective clinical responses to dacarbazine in patients with metastatic CRC are confined to those tumors harboring epigenetic inactivation of the DNA repair enzyme MGMT.23422094
Stomach CarcinomaEpigenetic AlterationsDNA methylation, dysregulation of miR-34c-5p, and MAPT expression are critical factors in the chemoresistance of gastric cancer to paclitaxel.23423488
Primary malignant neoplasmEpigenetic AlterationsMTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.23423488
diabeticEpigenetic AlterationsHistone modifications and recruitment of the nuclear transcriptional factor-kB (p65 subunit) at the MMP-9 promoter and the activity of lysine-specific demethylase 1 (LSD1) were measured in the retina from streptozotocin-induced diabetic rats.23423566
Diabetic RetinopathyEpigenetic AlterationsRegulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy.23423566
Diabetic RetinopathyEpigenetic AlterationsHuman donors with diabetic retinopathy had similar epigenetic changes at the MMP-9 promoter.23423566
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are mostly located at cancer-associated genomic regions or in fragile sites, suggesting their important role in the pathogenesis of human cancers.23424776
AdenomaEpigenetic AlterationsTo shed light on RCT pathogenesis, we investigated genetic and epigenetic alterations in two cases of pure and composite RCT and compared them with the profiles of matched adenomas and normal mucosa.23425390
Stomach CarcinomaEpigenetic AlterationsAssociation of microRNA-181c expression with the progression and prognosis of human gastric carcinoma.23425811
LymphomaEpigenetic AlterationsMiRNAs located in 14q32-31 were underexpressed in splenic marginal zone lymphoma compared with reactive lymphoid tissues and other B-cell lymphomas.23429603
Carcinogenesis, NeoplasmsEpigenetic AlterationsEmerging evidence has shown that microRNAs (miRNAs) participate in human carcinogenesis as tumor suppressors or oncogenes.23430406
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs are potentially very useful biomarkers in the diagnosis of cancer.23430754
Pancreatic carcinomaEpigenetic AlterationsWe sought to identify specific microRNAs in peripheral blood mononuclear cells (PBMCs) whose levels might facilitate diagnosis of pancreatic cancer.23430754
Pancreatic carcinoma, Borderline Personality DisorderEpigenetic AlterationsFirst, we used sequencing technology to identify differentially expressed microRNAs in PBMC of pancreatic cancer, BPD, and healthy controls (n = 20 in each group).23430754
Malignant tumor of colon, NeoplasmsEpigenetic AlterationsMicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7.23435373
Malignant NeoplasmsEpigenetic AlterationsBecause it is a member of the miR-106b~25 cluster, microRNA-25 (miR-25) is known to be dysregulated in human cancers.23435373
Primary malignant neoplasmEpigenetic AlterationsDNA methylation patterns are associated with the development and prognosis of cancer.23436614
Liver carcinomaEpigenetic AlterationsElucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma.23437062
Hollings Cancer CenterEpigenetic AlterationsSubstantial changes of DNA methylation at a genome-wide level were observed in HCC.23437062
Malignant neoplasm of liver, Hollings Cancer CenterEpigenetic AlterationsUnderstanding epigenetic changes in HCC will help to elucidate the pathogenesis and may eventually lead to identification of molecular markers for liver cancer diagnosis, treatment and prognosis.23437062
Primary malignant neoplasm, Leukemia, Myelocytic, AcuteEpigenetic AlterationsEmerging evidence has suggested that circulating microRNAs (miRNAs) could serve as noninvasive biomarkers for cancer detection; however, little is known about circulating miRNA profiles in AML patients.23437222
Leukemia, Myelocytic, AcuteEpigenetic AlterationsIdentification of circulating microRNAs as potential biomarkers for detecting acute myeloid leukemia.23437222
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThese data demonstrated that the expression patterns of circulating miRNAs were systematically altered in AML and miR-181b-5p may serve as a predictor for overall survival in AML patients.23437222
Ataxia Telangiectasia, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer.23437304
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsmiR-18a is one of the most up-regulated miRNAs in colorectal cancers (CRC) based on miRNA profiling.23437304
PathologyEpigenetic AlterationsOur experimental data suggest that a specific set of circulating miRNAs is secreted in the vitreous, which is quite different from the miRNA pattern in serum, and that the quantity of vitreal miRNAs could change, depending on the pathologies of the eye.23441115
Humor, DiseaseEpigenetic AlterationsMicroRNAs in vitreus humor from patients with ocular diseases.23441115
Disease, Vitreous humorEpigenetic AlterationsBased on evidence that microRNAs (miRNAs) are found in many biologic fluids (e.g., urine, saliva, pleural fluid), we sought to detect the presence of miRNAs and analyze their profile in vitreous humor (VH) from patients affected by various ocular diseases.23441115
Colorectal Cancer PathwayEpigenetic AlterationsIdentification of microRNAs regulated by isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic colorectal cancer.23441612
ovarian neoplasmEpigenetic AlterationsSerous ovarian cancer tissues displayed decreased DNA methylation in the promoter region of PARP1 compared to normal tissue, and methylation intensity correlated inversely with PARP1 mRNA levels.23442605
Heart failureEpigenetic AlterationsIncreased miRNA levels were strongly associated with increased risk of mortality or heart failure within 30 days for miR-208b (OR 1.79, 95% CI = 1.38-2.23, p = 1 x 10(-5)) and miR-499-5p (OR 1.70, 95% CI = 1.31-2.20, p = 5 x 10(-5)) but the association was lost when adjusting for Troponin T. During surgery miR-208b and miR-499-5p was released in the coronary sinus after cardioplegia-reperfusion to markedly higher levels than in a peripheral vein.23448306
Heart failure, Cessation of lifeEpigenetic AlterationsOur findings confirm increased levels of cardio-enriched miRNAs in the blood of MI patients and establish association of increased miRNA levels with reduced systolic function after MI and risk of death or heart failure.23448306
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsCirculating cardio-enriched microRNAs are associated with long-term prognosis following myocardial infarction.23448306
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsIncreased levels of cardio-enriched microRNAs (miRNAs) have been described in patients with myocardial infarction (MI).23448306
Heart failure, Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsmiRNAs were assessed for discrimination of a clinical diagnosis of myocardial infarction and for association with 30-day mortality and diagnosis of heart failure.23448306
Liver carcinomaEpigenetic AlterationsEpigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.23449122
Malignant neoplasm of kidneyEpigenetic AlterationsIn addition to HIF-1 regulating miR-210 in renal cancer, HIF-2 can regulate this microRNA in the absence of HIF-1.23449350
Malignant neoplasm of kidneyEpigenetic AlterationsMicroRNA-210 is upregulated in renal cancer compared with normal renal cortex tissue.23449350
NeoplasmsEpigenetic AlterationsExosomal microRNA (miR) content differed between MM and normal BM-MSCs, with a lower content of the tumor suppressor miR-15a.23454749
Carcinogenesis, AneuploidyEpigenetic AlterationsSubsequent acquisition of aneuploidy leads to subtle but distinct transcriptional alterations, revealing novel target genes that drive genomic instability and thus carcinogenesis.23455720
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-335 acts as a candidate tumor suppressor in prostate cancer.23456549
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-335 (miR-335) acts as a tumor suppressor or a tumor promoter in different human malignancies.23456549
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe loss of this microRNA might be associated with clinical progression of PCa patients.23456549
Colorectal Cancer PathwayEpigenetic AlterationsA plasma microRNA panel for early detection of colorectal cancer.23456911
Clinical Coordinator, Neoplasm MetastasisEpigenetic AlterationsMoreover, the diagnostic performance of the microRNA panel persisted in nonmetastasis CRC stages (Dukes A-B, AUC: 0.809 and 0.892 for training and validation dataset, respectively) and in metastasis CRC stages (Dukes C-D, AUC: 0.917 and 0.865 for training and validation dataset, respectively).23456911
Clinical CoordinatorEpigenetic AlterationsIn conclusion, our study reveals a plasma microRNA panel that has potential clinical value in early CRC detection and would play a critical role on preliminarily screening CRC in general population.23456911
Papillary neoplasmEpigenetic AlterationsMicroRNA-146a targets PRKCE to modulate papillary thyroid tumor development.23457043
SERPINB3 wt AlleleEpigenetic AlterationsOur results indicate that microRNA polymorphisms modify the risk of OSCC associated with HPV16 seropositivity, particularly in patients with SCCOP and never smokers.23457596
Communicable Diseases, Squamous cell carcinoma, SERPINB3 wt AlleleEpigenetic AlterationsBoth microRNAs and human papillomavirus (HPV) infection play an important role in the development and progression of oral squamous cell carcinoma (OSCC).23457596
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are small non-coding genes which become dysregulated in cancer and may predict survival.23458262
MetastasisEpigenetic AlterationsThree miRNA sets were significantly associated with overall survival (miR-107, miR-151, miR-492; P = 0.0002), disease-free survival (miR-20b, miR-107, miR-151, miR-182, miR-361; P = 0.0001), and distant metastasis (miR-151, miR-152, miR-324-5p, miR-361, miR492; P = 0.0087), which retained significance even after adjusting for p16 status.23459718
Human Papillomavirus Positive Oropharyngeal Squamous Cell CarcinomaEpigenetic AlterationsPotentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma.23459718
Malignant NeoplasmsEpigenetic AlterationsDeregulation of miRNAs is associated with almost all human malignancies.23459718
MetastasisEpigenetic AlterationsThe associated biologic functions of these miRNAs include immune surveillance, treatment resistance, invasion, and metastasis.23459718
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) are endogenous small noncoding RNAs that negatively regulate gene expression at the posttranscriptional level and play an important role in carcinogenesis.23461060
Malignant NeoplasmsEpigenetic AlterationsThen, we validated the detective ability of this miRNA panel in a testing set of 34 malignant tumor patients, 30 patients with benign pulmonary nodules and 32 healthy smokers.23462458
Carcinoma of lungEpigenetic AlterationsIdentification of plasma microRNAs as novel noninvasive biomarkers for early detection of lung cancer.23462458
Carcinoma of lungEpigenetic AlterationsUsing quantitative reverse transcriptase PCR analysis, we first selected and identified three aberrant plasma expression miRNAs (miR-21, miR-145, and miR-155) in a training set of 62 patients and 60 healthy smokers to define a panel that had high diagnostic efficiency for lung cancer.23462458
Carcinoma of lungEpigenetic AlterationsThe three miRNAs used in combination produced the area under receiver operating characteristic curve at 0.847, which helped distinguish lung cancer from healthy smokers with 69.4% sensitivity and 78.3% specificity.23462458
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsIdentification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.23462794
WFS1 geneEpigenetic AlterationsSuccessful DNA methylation data were generated for 16 of these 19 CpG-SNP loci, representing the candidate genes TCF7L2, KCNQ1, PPARG, HHEX, CDKN2A, SLC30A8, DUSP9, CDKAL1, ADCY5, SRR, WFS1, IRS1, DUSP8, HMGA2, TSPAN8 and CHCHD9.23462794
WFS1 geneEpigenetic AlterationsMoreover, six CpG-SNPs, representing TCF7L2, KCNQ1, CDKN2A, ADCY5, WFS1 and HMGA2, were also associated with DNA methylation of surrounding CpG sites.23462794
Diabetes MellitusEpigenetic AlterationsOur results suggest that the introduction or removal of a CpG site may be a molecular mechanism through which some of the type 2 diabetes SNPs affect gene function via differential DNA methylation and consequently contributes to the phenotype of the disease.23462794
B-Cell Lymphomas, Diffuse Large B-Cell LymphomaEpigenetic AlterationsLow expression of microRNA-129-5p predicts poor clinical outcome in diffuse large B cell lymphoma (DLBCL).23463124
Diffuse Large B-Cell LymphomaEpigenetic AlterationsMicroRNA expression provides a new and interesting tool for understanding the biology and clinical course of DLBCL.23463124
NeoplasmsEpigenetic AlterationsNo significant difference was found among microRNA-129-5p expression in tumor tissue, the tissue surrounding the tumor, and normal controls.23463124
Diffuse Large B-Cell LymphomaEpigenetic AlterationsTo our knowledge, this is the first report to show that the expression of microRNA-129-5p can affect the clinical outcome of DLBCL patients and that microRNA-129-5p may be involved in the biology of DLBCL development, although larger studies are necessary to confirm this.23463124
Diffuse Large B-Cell LymphomaEpigenetic AlterationsFurther investigations may also help to elucidate the biological role of microRNA-129-5p in DLBCL.23463124
Functional disorder, Coronary Artery DiseaseEpigenetic AlterationsMicroRNA (miRNA) expression profiles in endothelial progenitor cells (EPCs) contribute to EPC dysfunction in patients suffering from coronary artery disease.23465244
Extracellular MatrixEpigenetic AlterationsSixteen miRNAs (miR-126, miR-508-5p, miR-34a, miR-210, miR-490-3p, miR-513-5p, miR-517c, miR-518e, miR-589, miR-220c, miR-200a*, miR-186*, miR-7i*, miR-200b*, miR-595, and miR-662) were found to be differentially expressed between ICM and NICM patients.23465244
Congestive heart failure, Extracellular MatrixEpigenetic AlterationsThe miRNAs miR-126 and miR-508-5p are associated with the outcome of ICM and NICM patients with CHF.23465244
Congestive heart failureEpigenetic AlterationsThese two miRNAs could be useful in the diagnosis of CHF patients, and might provide novel targets for prevention and treatment of CHF.23465244
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsIncreasing evidence has lent support to the notion that miRNAs regulate hepatocellular carcinoma (HCC) cell proliferation by directly targeting cell cycle-related genes.23466643
Barrett EsophagusEpigenetic AlterationsMicroRNA expression signatures during malignant progression from Barretts esophagus to esophageal adenocarcinoma.23466817
Barrett EsophagusEpigenetic AlterationsThe majority of miRNA aberrations involved upregulation of expression in Barretts esophagus and esophageal adenocarcinoma tissues, with the most dramatic alterations occurring at the Barretts metaplasia stage.23466817
Barrett Esophagus, Adenocarcinoma Of EsophagusEpigenetic AlterationsThe significant miRNA alterations that were exclusive to esophageal adenocarcinoma but not Barretts esophagus included miR-375 downregulation and upregulation of five members of the miR-17-92 and its homologue clusters, which may become promising biomarkers for esophageal adenocarcinoma development.23466817
Barrett Esophagus, NeoplasmsEpigenetic AlterationsKnown oncomiRs, such as miR-21, miR-25, and miR-223, and tumor suppressor miRNAs, including miR-205, miR-203, let-7c, and miR-133a, showed progressively altered expression from Barretts esophagus to esophageal adenocarcinoma.23466817
Breast CarcinomaEpigenetic AlterationsEpigenetic analyses have shown that aberrant DNA methylation signatures are associated with breast cancer molecular subtypes.23467623
Breast CarcinomaEpigenetic AlterationsBy using pyrosequencing, we analyzed the DNA methylation status of 5 candidate genes in 60 breast cancer samples.23467623
Breast CarcinomaEpigenetic AlterationsOur results indicate that the basal-like subtype is associated with low methylation levels of the SFRP1 gene, suggesting that the methylation levels of specific breast cancer genes may potentially serve as epigenetic biomarkers and prognostic factors.23467623
Damper Device, Breast CarcinomaEpigenetic AlterationsDampening enthusiasm for circulating microRNA in breast cancer.23472110
Breast CarcinomaEpigenetic AlterationsGenome-wide platforms for high-throughput profiling of circulating miRNA (oligoarray or miR-Seq) offer enormous promise for agnostic discovery of circulating miRNA biomarkers as a pathway for development in breast cancer detection.23472110
Primary malignant neoplasmEpigenetic AlterationsAccumulating evidences indicate that dysregulated microRNAs (miRNA) are involved in cancer tumorigenesis and progression.23474644
CholangiocarcinomaEpigenetic AlterationsClassification of mid/distal bile duct cancer by both genetic and epigenetic profiles may improve the accuracy in predicting outcome and the effectiveness of tailored therapy in these diseases.23478949
Malignant neoplasm of endometriumEpigenetic AlterationsExpression of type 2 orexin receptor in human endometrium and its epigenetic silencing in endometrial cancer.23482607
Hepatitis C Virus-Related Hepatocellular CarcinomaEpigenetic AlterationsABCB6 mRNA and DNA methylation levels serve as useful biomarkers for prediction of early intrahepatic recurrence of hepatitis C virus-related hepatocellular carcinoma.23483087
childhood nasal type extranodal NK/T-cell lymphomaEpigenetic Alterations[Expression of MCL-1 and microRNA-29a in extranodal NK/T-cell lymphoma tissue].23484699
Breast CarcinomaEpigenetic AlterationsMicroRNA-21 as an indicator of aggressive phenotype in breast cancer.23485999
Liver carcinomaEpigenetic AlterationsMiR-124 and miR-203 function as tumor-suppressor microRNAs silenced by DNA methylation in hepatocellular carcinoma.23487440
Breast Carcinoma, Metastasis, NeoplasmsEpigenetic AlterationsSenescence-associated microRNA, miR-22, suppresses tumor growth and metastasis in vivo in a murine breast cancer model, and exosomal senescence-associated microRNA may affect the tumor microenvironment.23487440
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs in Cancer: the 22nd Hiroshima Cancer Seminar/the 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima.23487440
Breast Cancer Cell, Primary malignant neoplasm, CarcinogenesisEpigenetic AlterationsThe joint international symposium of the 22nd Hiroshima Cancer Seminar and the 4th Japanese Association for RNA Interference focused on a pivotal role of microRNAs in carcinogenesis, progression and therapy of human cancer.23487440
Carcinoma of lung, NeoplasmsEpigenetic AlterationsThe therapeutic potential of microRNAs for preventing and treating lung cancer using the Kras(LSL-G12D/+);p53(LSL-R172H/+)mouse model suggests that miR-34 may be useful in sensitizing tumors to other conventional therapeutics.23487440
Transitional cell carcinoma of bladderEpigenetic AlterationsExpression profile of microrna-145 in urothelial bladder cancer.23489501
MS geneEpigenetic AlterationsCirculating microRNAs as biomarkers for disease staging in multiple sclerosis.23494648
Antilymphocyte Serum, Amyotrophic Lateral SclerosisEpigenetic AlterationsInterestingly, the same circulating miRNAs (let-7 and miR-92) that were differentially expressed in RRMS versus SPMS also differentiated amyotrophic lateral sclerosis (ALS) from RRMS subjects, but were not different between SPMS and ALS, suggesting that similar processes may occur in SPMS and ALS.23494648
Malignant NeoplasmsEpigenetic AlterationsAberrant DNA methylation is a common epigenetic alteration and an important feature in human cancers.23495895
ovarian neoplasm, Primary malignant neoplasmEpigenetic AlterationsAlthough we still have a long way to go before an effective and nontoxic miRNA-based cancer therapy can be introduced into the clinic, the inhibition of integrin a5 expression by targeting miR-92a needs to be explored further for future applications in ovarian cancer treatment.23499550
Atrial FibrillationEpigenetic AlterationsRegulation of the SK3 channel by microRNA-499--potential role in atrial fibrillation.23499625
Atrial FibrillationEpigenetic AlterationsMicroRNAs are important regulators of gene expression, including those involving electrical remodeling in atrial fibrillation (AF).23499625
Prostate Cancer PathwayEpigenetic AlterationsProstatic concentrations of 1,25D positively correlated with these miRNA levels in both prostate cancer and benign epithelium, showing that patients with prostate cancer may still benefit from vitamin D3.23503652
Prostate Lymphoma, NeoplasmsEpigenetic AlterationsTumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue.23503652
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsTogether, these findings show that vitamin D3 supplementation augments tumor suppressive miRNAs in patient prostate tissue, providing evidence that miRNAs could be key physiologic mediators of vitamin D3 activity in prevention and early treatment of prostate cancer.23503652
Primary malignant neoplasmEpigenetic AlterationsEpigenetic regulations including DNA methylation and histone modification control gene expression and play important roles during cancer progression.23504335
Degenerative polyarthritisEpigenetic AlterationsAlterations in DNA methylation patterns have been found to correlate with several diseases including osteoarthritis (OA).23505229
Degenerative polyarthritisEpigenetic AlterationsDNA methylation profiling was performed using Illumina Infinium HumanMethylation27 in 25 patients with OA and 20 healthy controls.23505229
Degenerative polyarthritisEpigenetic AlterationsWe were able to identify a tight subgroup of patients with OA, characterised by an increased inflammatory response that could be regulated by epigenetics.23505229
GliomaEpigenetic AlterationsAltered expression of MGMT in high-grade gliomas results from the combined effect of epigenetic and genetic aberrations.23505468
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsDoes DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?23505498
Diabetes Mellitus, Non-Insulin-Dependent, Islets of LangerhansEpigenetic AlterationsEpigenetics may play a role in the pathophysiology of type 2 diabetes (T2D), and increased DNA methylation of the metabolic master regulator peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) has been reported in muscle and pancreatic islets from T2D patients and in muscle from individuals at risk of T2D.23505498
FamilyEpigenetic AlterationsNo significant effect of familiality on DNA methylation was found.23505498
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsTaken together, increased DNA methylation of the PPARGC1A promoter is unlikely to play a major causal role for the development of insulin resistance in FDR of patients with T2D.23505498
Colorectal Cancer Pathway, Loss of HeterozygosityEpigenetic AlterationsSomatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients.23505554
Colorectal Cancer PathwayEpigenetic AlterationsOur goal was to characterize the relationships between CSMD1 somatic mutations, allele imbalance, DNA methylation, and the clinical characteristics in colorectal cancer patients.23505554
Colorectal NeoplasmsEpigenetic AlterationsFinally, we performed methylation-specific PCR on 76 colorectal tumors to determine DNA methylation status for CSMD1 and known methylation targets ALX4, RUNX3, NEUROG1, and CDKN2A.23505554
Colorectal Cancer PathwayEpigenetic AlterationsHigh expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer.23506979
Malignant tumor of colonEpigenetic AlterationsFinally, we also found that these miRNAs were up-regulated in oxaliplatin resistant HCT116/oxPt (miR-625-3p, miR-181b and miR-27b) and LoVo/oxPt (miR-181b) colon cancer cell lines as compared with their isogenic parental cells.23506979
Injury of liverEpigenetic AlterationsCirculating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B.23508904
Communicable Diseases, Hepatitis BEpigenetic AlterationsHepatitis B virus (HBV) infection is associated with increased expression of microRNA-122.23508904
Fibrosis AssessmentEpigenetic AlterationsMicroRNA-122 levels were also lower in patients with advanced liver fibrosis (P < 0.001) and lower inflammatory activity (P < 0.025).23508904
Hepatitis BEpigenetic AlterationsAssociation of polymorphism in MicroRNA 219-1 with clearance of hepatitis B virus infection.23508906
Communicable Diseases, Hepatitis BEpigenetic AlterationsPolymorphisms in the primary microRNA region may be associated with natural course of hepatitis B virus (HBV) infection.23508906
Communicable DiseasesEpigenetic AlterationsThis result suggests that polymorphisms in the pri-miRNA region of miR-219-1 might be a genetic factor for HBV clearance after infection.23508906
LeukoplakiaEpigenetic AlterationsWe identified a specific miRNA signature that is aberrantly expressed in progressing oral LGD leukoplakias.23510112
Primary malignant neoplasmEpigenetic AlterationsThese results show promise for using saliva miRNA signature for monitoring of cancer precursor lesions and early detection of disease progression.23510112
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is an epigenetic process which has been involved as an important pathogenic factor of cancer.23513484
Squamous cell carcinoma of esophagusEpigenetic AlterationsRecently, emerging studies have suggested that an aberrant microRNA (miRNA) expression signature exists in ESCC.23516093
Squamous cell carcinoma of esophagusEpigenetic AlterationsThus, our data present new evidence for the important roles of miRNAs in ESCC.23516093
Acute myocardial infarctionEpigenetic AlterationsAspirin protects human coronary artery endothelial cells against atherogenic electronegative LDL via an epigenetic mechanism: a novel cytoprotective role of aspirin in acute myocardial infarction.23519265
NeoplasmsEpigenetic AlterationsThe expression of let-7a miRNA in serum, tumor tissues, and peritumoral tissues was measured by real-time PCR.23519840
Gastric Adenocarcinoma, NeoplasmsEpigenetic AlterationsThe let-7a miRNA levels in the serum and tumor tissues of gastric adenocarcinoma patients were significantly lower than in the serum of healthy controls and peritumoral tissues, respectively.23519840
Gastric AdenocarcinomaEpigenetic AlterationsDicer 1 protein positively correlated with let-7a miRNA level, but negatively correlated with CCR7 protein level in gastric adenocarcinoma.23519840
Tetranitromethane, Metastasis, NeoplasmsEpigenetic AlterationsNegative Dicer 1 protein and let-7a miRNA expression and positive CCR7 protein expression significantly correlated with lymph node metastasis, depth of invasion, high clinical TNM stage, and larger tumor size.23519840
Stomach Carcinoma, MetastasisEpigenetic AlterationsHigh expression of CCR7 protein and low expression of Dicer 1 protein and let-7a miRNA are significantly associated with the metastasis and progression of gastric cancer.23519840
Stomach CarcinomaEpigenetic AlterationsHigh CCR7 protein expression may be caused by the loss of Dicer 1 protein expression and reduced let-7a miRNA level in gastric cancer.23519840
Refractory Cytopenia of ChildhoodEpigenetic AlterationsOur results indicated that LRP1B was frequently downexpressed in human RCC tissue and cell lines, which involved both epigenetic events (DNA methylation and histone deacetylation) and N-terminal deletion of LRP1B.23521319
Secondary malignant neoplasm of liver, Colorectal Cancer PathwayEpigenetic AlterationsGlobal histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer.23523318
Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsIn chronic lymphocytic leukemia (CLL) patients, disruptions of the TP53 tumor suppressor pathway by 17p13 deletion (del17p), somatic TP53 mutations, or downregulation of microRNA-34a have been associated with a poor prognosis.23525797
Breast CarcinomaEpigenetic AlterationsOur results suggest that germline variation in the 5 region proximal to pre-miRNA gene sequences may be associated with breast cancer risk among African Americans and breast cancer-specific survival generally; however, further validation is needed to confirm these findings.23526039
Liver carcinomaEpigenetic AlterationsSirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients.23526469
Chronic liver disease, Hollings Cancer CenterEpigenetic AlterationsLoss of SIRT6 induces epigenetic changes that may be relevant to chronic liver disease and HCC development.23526469
Hollings Cancer Center, Primary malignant neoplasmEpigenetic AlterationsOur data demonstrate that deficiency in one epigenetic regulator predisposes a tumorigenic phenotype that ultimately has relevance for outcome of HCC and other cancer patients.23526469
Breast CarcinomaEpigenetic AlterationsDownregulation of miRNA-128 sensitises breast cancer cell to chemodrugs by targeting Bax.23526655
Urinary Bladder, SchistosomiasisEpigenetic AlterationsHere we evaluated aberrant promoter DNA methylation as a potential biomarker to detect severe bladder damage that is associated with schistosomiasis by analyzing urine specimens.23527093
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, NeoplasmsEpigenetic AlterationsEpigenetic alterations of the transcription factor 21 (TCF21) gene have been associated with head and neck squamous cell carcinoma (HNSCC) and other tumor entities.23529585
Squamous cell carcinoma of the head and neck, Human papilloma virus infectionEpigenetic AlterationsThese epigenetic, and possibly also genetic, alterations of the TCF21 gene in HNSCCs may be driven by HPV infection, nicotine and alcohol abuse, or both.23529585
Nasopharyngeal carcinoma, Metastasis, NeoplasmsEpigenetic AlterationsExpression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma.23529758
SCYL1 geneEpigenetic AlterationsWe show that EZH2 upregulation is mediated by MYC-induced repression of its regulatory micro RNAs and EZH2 exerts oncogenic properties in NKTL.23529930
Endometrial CarcinomaEpigenetic AlterationsEpigenetic regulation of L1CAM in endometrial carcinoma: comparison to cancer-testis (CT-X) antigens.23530769
Malignant neoplasm of thyroidEpigenetic AlterationsThe acetylation status of histones is involved in the epigenetic control of gene expression and is usually disrupted in advanced thyroid cancer.23531031
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery.23532818
Papillary thyroid carcinomaEpigenetic AlterationsDifferential expression profiling and functional analysis of microRNAs through stage I-III papillary thyroid carcinoma.23533107
F9 geneEpigenetic AlterationsBiological function analysis showed that target genes were involved in five aspects including cell proliferation, differentiation, apoptosis, cycle, and signaling transduction pathway, suggesting the regulatory role of abnormal expression of critical miRNAs in the pathogenesis of PTC.23533107
ChordomaEpigenetic AlterationsChordoma characterization of significant changes of the DNA methylation pattern.23533570
ChordomaEpigenetic AlterationsIn summary, we have shown that chordomas are characterized by a significant genomic instability and furthermore we demonstrated a characteristic DNA methylation pattern.23533570
Stomach CarcinomaEpigenetic AlterationsDiet folate, DNA methylation and polymorphisms in methylenetetrahydrofolate reductase in association with the susceptibility to gastric cancer.23534741
Stomach CarcinomaEpigenetic AlterationsMethylenetetrahydrofolate reductase (MTHFR) has been reported to be associated with DNA methylation, an epigenetic feature frequently found in gastric cancer.23534741
Sarcoma - category (morphologic abnormality)Epigenetic AlterationsGrowth rate of late passage sarcoma cells is independent of epigenetic events but dependent on the amount of chromosomal aberrations.23535008
SarcomaEpigenetic AlterationsSoft tissue sarcomas (STS) are characterized by co-participation of several epigenetic and genetic events during tumorigenesis.23535008
Gain, Primary malignant neoplasmEpigenetic AlterationsCollectively, our data demonstrate that these fairly differentiated/advanced cancer cell lines have still the potential to gain an additional spontaneous growth benefit without external influences and that maintenance of increased proliferative potential towards longevity of STS cells (having crossed senescence barriers) may be independent of overt epigenetic alterations.23535008
Childhood LeukemiaEpigenetic AlterationsRecently, epigenetic regulation of CEBPA expression through DNA methylation has been demonstrated in leukemia.23541085
ovarian neoplasmEpigenetic AlterationsDetection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients.23542579
Breast Cancer CellEpigenetic AlterationsRecent studies have suggested that miRNA deregulation is associated with the initiation and progression of human cancer.23542579
Primary malignant neoplasm, AscitesEpigenetic AlterationsOut of 2222 kinds of total miRNAs that were identified in the microarray analysis, 95 miRNAs were down-regulated and 88 miRNAs were up-regulated, in the serum, tissue, and ascites of cancer patients.23542579
ovarian neoplasmEpigenetic AlterationsAmong the miRNAs that showed a consistent regulation tendency through all specimens and showed more than a 2-fold difference in serum, 5 miRNAs (miR-132, miR-26a, let-7b, miR-145, and miR-143) were determined as the 5 most markedly down-regulated miRNAs in the serum from ovarian cancer patients with respect to those of controls.23542579
ovarian neoplasmEpigenetic AlterationsFour miRNAs (miR-132, miR-26a, let-7b, and miR-145) out of 5 selected miRNAs were significantly underexpressed in the serum of ovarian cancer patients in qRT-PCR.23542579
ovarian neoplasmEpigenetic AlterationsAlso, serum miRNAs is a promising and useful tool for discriminating between controls and patients with serous ovarian cancer.23542579
Adenocarcinoma of lung (disorder)Epigenetic AlterationsDNA methylation profiles at precancerous stages associated with recurrence of lung adenocarcinoma.23544068
Adenocarcinoma of lung (disorder)Epigenetic AlterationsThe aim of this study was to clarify the significance of DNA methylation alterations at precancerous stages of lung adenocarcinoma.23544068
Adenocarcinoma of lung (disorder)Epigenetic AlterationsStepwise progression of DNA methylation alterations from normal lung tissue to non-cancerous lung tissue obtained from patients with lung adenocarcinomas, and then tumorous tissue samples, was observed at 3,270 CpG sites, suggesting that non-cancerous lung tissue obtained from patients with lung adenocarcinomas was at precancerous stages with DNA methylation alterations.23544068
Adenocarcinoma of lung (disorder)Epigenetic AlterationsAt CpG sites of 2,083 genes, DNA methylation status in samples of non-cancerous lung tissue obtained from patients with lung adenocarcinomas was significantly correlated with recurrence after establishment of lung adenocarcinomas.23544068
Aggressive behaviorEpigenetic AlterationsThese data suggest that DNA methylation alterations at precancerous stages determine tumor aggressiveness and outcome through silencing of specific genes.23544068
Acute myocardial infarctionEpigenetic AlterationsMicroRNA-150: a novel marker of left ventricular remodeling after acute myocardial infarction.23547171
NeoplasmsEpigenetic AlterationsMicroRNAs have been reported to play roles as oncogenes or tumor suppressor genes in human cancers.23548968
NeoplasmsEpigenetic AlterationsASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance.23549872
Breast CarcinomaEpigenetic AlterationsThese findings support the hypothesis that a SNP located in igf-1r gene may alter miRNA regulation of IGF-1R, with a putative effect on BRCA1 penetrance and breast cancer risk.23549953
Hollings Cancer CenterEpigenetic AlterationsThese results demonstrate the potential of MALDI IMS for uncovering new relevant biomarkers of MiVI in HCC, and highlight the role of epigenetic modifications in the prognosis of HCC.23553687
Primary Neoplasm, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsOur observations suggest that cancer cells in omental tumors express key miRNAs differently than primary tumors, and that at least some of these microRNAs may be critical regulators of the emergence of drug resistant disease.23554878
ovarian neoplasmEpigenetic AlterationsIdentification of ovarian cancer metastatic miRNAs.23554878
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsGenistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer.23554959
Malignant NeoplasmsEpigenetic AlterationsGenistein has been shown to inhibit cancers both in vitro and in vivo, by altering the expression of several microRNAs (miRNAs).23554959
Hormone refractory prostate cancerEpigenetic AlterationsWe used Enhanced Reduced Representation Bisulfite Sequencing, a genome-wide high-coverage single-base resolution DNA methylation method to profile seven localized PCa samples, seven matched benign prostate tissues, and six aggressive castration-resistant prostate cancer (CRPC) samples.23555183
NeoplasmsEpigenetic AlterationsWe found that most DNA methylation changes occurred in the context of ASM, suggesting that variations in tumor epigenetic landscape of individuals are partly mediated by genetic differences, which may affect PCa disease progression.23555183
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsWe further selected a panel of 13 CGIs demonstrating increased DNA methylation with disease progression and validated this panel in an independent cohort of 20 benign prostate tissues, 16 PCa, and 8 aggressive CRPCs.23555183
Primary malignant neoplasmEpigenetic AlterationsSeveral of the most significantly altered loci (CAV1, EVX1, MCF2L, and FGF1) were then used as probes to map the extent of these DNA methylation changes in normal tissues from prostates containing cancer.23555185
CHOANAL ATRESIA, POSTERIOR, Peripheral zone of prostateEpigenetic AlterationsThese mapping studies indicate that a spatially widespread epigenetic defect occurs in the peripheral prostate tissues of men who have PCa that may be useful in the detection of this disease.23555185
Breast CarcinomaEpigenetic AlterationsThere is no association between microRNA gene polymorphisms and risk of triple negative breast cancer in a Chinese Han population.23555923
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miRNA) as a novel modulator of gene expression has played an important regulatory role in the malignancy.23555923
Malignant NeoplasmsEpigenetic AlterationsAberrant expression of microRNA-146a (miR-146a) has been reported to be involved in the development and progression of various types of cancers.23555954
NeoplasmsEpigenetic AlterationsGlobal histone modification patterns correlate with tumor phenotypes and prognostic factors in multiple tumor types.23557258
Primary malignant neoplasmEpigenetic AlterationsRecent studies suggest that aberrant histone modifications play an important role in cancer.23557258
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsTumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma.23558898
Malignant Neoplasms, Maxillary Sinus Squamous Cell CarcinomaEpigenetic AlterationsOur recent studies of microRNA (miRNA) expression signature demonstrated that microRNA-874 (miR-874) was significantly downregulated in maxillary sinus squamous cell carcinoma (MSSCC), and a putative tumour-suppressive miRNA in human cancers.23558898
Primary malignant neoplasmEpigenetic AlterationsRecognition of tumour-suppressive miRNA-mediated cancer pathways provides new insights into the potential mechanisms of HNSCC oncogenesis and suggests novel therapeutic strategies for the disease.23558898
Primary malignant neoplasm, Uterine Corpus Sarcoma, NeoplasmsEpigenetic AlterationsAs aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expression profiles of the major uterine sarcoma subtypes and mixed epithelial-mesenchymal tumors of the uterus.23558962
Uterine Neoplasms, Uterine Corpus SarcomaEpigenetic AlterationsmicroRNAs in uterine sarcomas and mixed epithelial-mesenchymal uterine tumors: a preliminary report.23558962
Carcinoma of lung, Pneumonia, Tuberculosis, PulmonaryEpigenetic AlterationsDifferential microRNAs expression in serum of patients with lung cancer, pulmonary tuberculosis, and pneumonia.23559272
Tuberculosis, Pulmonary, Carcinoma of lung, Infectious Lung Disorder, Pneumonia, Primary malignant neoplasmEpigenetic AlterationsSeveral studies have shown that aberrant expression of miRNAs in human cancer including lung cancer, but little is known about their effects on some infectious lung diseases such as pulmonary tuberculosis (TB) and pneumonia.23559272
Esophageal carcinomaEpigenetic AlterationsSalivary microRNAs as promising biomarkers for detection of esophageal cancer.23560033
Malignant NeoplasmsEpigenetic AlterationsTissue microRNAs (miRNAs) can detect cancers and predict prognosis.23560033
Esophageal carcinomaEpigenetic AlterationsBy Agilent microarray, six deregulated miRNAs from whole saliva samples from seven patients with esophageal cancer and three healthy controls were selected.23560033
Esophageal carcinomaEpigenetic AlterationsThe six selected miRNAs were subjected to validation of their expression levels by RT-qPCR using both whole saliva and saliva supernatant samples from an independent set of 39 patients with esophageal cancer and 19 healthy controls.23560033
Esophageal carcinomaEpigenetic AlterationsWe found distinctive miRNAs for esophageal cancer in both whole saliva and saliva supernatant.23560033
Esophageal carcinomaEpigenetic AlterationsThese miRNAs possess discriminatory power for detection of esophageal cancer.23560033
Esophageal carcinomaEpigenetic AlterationsBecause saliva collection is noninvasive and convenient, salivary miRNAs show great promise as biomarkers for detection of esophageal cancer in areas at high risk.23560033
MetastasisEpigenetic AlterationsInterestingly, the expression levels of these miRNAs were also shown to be upregulated in widely invasive FTC (WI-FTC; n=13) that has distant metastasis and worse prognosis, indicating a close similarity in the miRNA expression between metastatic MI-FTC and WI-FTC.23563786
Squamous cell carcinoma, SERPINB3 wt AlleleEpigenetic AlterationsOral squamous cell carcinoma (OSCC) development involves complex machinery of genomic and epigenetic regulations including microRNA (miRNA) expression changes.23564792
Squamous cell carcinomaEpigenetic AlterationsmiRNA expression profiles of oral squamous cell carcinomas.23564792
Tetranitromethane, SERPINB3 wt AlleleEpigenetic AlterationsWe aimed to analyze the expression patterns of a set of miRNAs in human TNM stage I and II OSCC samples in an autologous normal mucosa-controlled experimental design.23564792
Infection caused by Helicobacter pylori, CarcinogenesisEpigenetic AlterationsInterleukin polymorphisms and Helicobacter pylori infection are believed to play critical roles in DNA methylation, a process frequently associated with carcinogenesis.23566094
Stomach CarcinomaEpigenetic AlterationsDNA methylation in gastric cancer seems to be influenced by the presence of interleukin polymorphisms and by the H. pylori cagA/vacAs1m1 strains.23566094
SepticemiaEpigenetic AlterationsSepsis and systemic inflammatory response syndrome induce considerable changes of methylation metabolism without apparent functional consequences on homocysteine plasma levels or DNA methylation.23566119
Childhood MedulloblastomaEpigenetic AlterationsEpigenetic Silencing of DKK3 in medulloblastoma.23567267
Clinical CoordinatorEpigenetic AlterationsSubsequently, we tried to correlate expression levels of analyzed miRNAs to clinical-pathological features of CRC patients.23568010
NeoplasmsEpigenetic AlterationsTo study epigenetics in clear-cell ovarian cancer, fresh frozen tumor DNA (n = 485) was assayed on Illumina Infinium HumanMethylation450 BeadChips.23571109
NeoplasmsEpigenetic AlterationsSeveral loci methylation inversely correlated with tumor gene expression, most notably KCNH2 (HERG, a potassium channel) (P = 9.5 x 10(-7)), indicating epigenetic silencing.23571109
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer (CRC) development involves underlying modifications at genetic/epigenetic level.23573237
NeoplasmsEpigenetic AlterationsThe Lenti-miRNA-VEGF-A+VEGF-C significantly inhibited the cell proliferation and tumor growth, compared with Lenti-miRNA-VEGF-A or Lenti-miRNA-VEGF-C (P<0.05).23573305
NeoplasmsEpigenetic AlterationsIn addition, Lenti-miRNA- VEGF-A+VEGF-C markedly lowered the tumor size in vivo in comparison with Lenti-miRNA-VEGF-A or Lenti-miRNA-VEGF-C (P<0.05).23573305
OsteosarcomaEpigenetic AlterationsMicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma.23574781
OsteosarcomaEpigenetic AlterationsThe investigation of miRNA expression between healthy subjects and patients with osteosarcoma is crucial for future clinical trials.23574781
OsteosarcomaEpigenetic AlterationsmiRNA profiling of osteosarcoma tissue samples showed that expression of 10 miRNAs had increased 10-fold compared with normal controls.23574781
DiseaseEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in the development, differentiation, and function of different cell types and in the pathogenesis of various human diseases.23574781
Primary malignant neoplasmEpigenetic AlterationsmiRNAs are differentially expressed in normal and cancer cells.23574781
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsWhile no miRNA alone differentiated localized PCa and mCRPC, combinations had greater sensitivity and specificity.23574937
Metastatic castration-resistant prostate cancerEpigenetic AlterationsPlasma miRNAs as biomarkers to identify patients with castration-resistant metastatic prostate cancer.23574937
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsWe identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated.23574937
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur results demonstrate that plasma levels of selected miRNAs are potential biomarkers to differentiate localized PCa and mCRPC.23574937
NeoplasmsEpigenetic AlterationsDiscovery and prevalidation of salivary extracellular microRNA biomarkers panel for the noninvasive detection of benign and malignant parotid gland tumors.23575476
Malignant NeoplasmsEpigenetic AlterationsA four miRNA combination was able to discriminate between saliva samples from patients with malignant tumors from those of patients with benign parotid gland tumors (sensitivity 69%, specificity 95%).23575476
NeoplasmsEpigenetic AlterationsSalivary miRNA profiles differ in saliva from patients with malignant from saliva from patients with a benign parotid gland tumor.23575476
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsWe measured DNA methylation at 27578 CpGs in blood samples from 298 women who developed breast cancer 0 to 5 years after enrollment in the Sister Study cohort and compared them with a random sample of 612 cohort women who remained cancer free.23578854
Liver carcinomaEpigenetic AlterationsFrequent DNA methylation of MiR-129-2 and its potential clinical implication in hepatocellular carcinoma.23580407
CarcinogenesisEpigenetic AlterationsRecently, microRNAs have been shown to play an important role in carcinogenesis, being regulated by DNA methylation in several cases.23580407
NeoplasmsEpigenetic AlterationsOur data suggest that GPX7 possesses tumour suppressor functions in OAC and is silenced by location-specific promoter DNA methylation.23580780
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-375 is downregulated in pancreatic cancer and inhibits cell proliferation in vitro.23581226
Malignant Neoplasms, Pancreatic carcinomaEpigenetic AlterationsAberrant expression of microRNA-375 (miR-375) has been reported to be involved in development and progression in various types of cancers, but few studies have been conducted to determine its relationship with pancreatic cancer.23581226
Pancreatic carcinomaEpigenetic AlterationsMicroRNAs (miRNAs) have emerged as important regulators in the development of pancreatic cancer and may be a valuable therapeutic application.23581226
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsEpigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimers disease (AD).23582657
NeoplasmsEpigenetic AlterationsMicroRNA miR-378 plays important roles in tumorigenesis by enhancing cell survival, reducing apoptosis, promoting tumor growth, angiogenesis and promoting cell migration and invasion.23582927
PterygiumEpigenetic AlterationsCorrelation of microRNA-145 levels and clinical severity of pterygia.23583047
Glioblastoma MultiformeEpigenetic AlterationsDifferential expression of MicroRNAs in patients with glioblastoma after concomitant chemoradiotherapy.23586679
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are significantly involved in the initiation and progression of numerous cancers; however, the role of miRNAs in recurrence of tumors remains unknown.23586679
Cessation of lifeEpigenetic AlterationsBioinformatic analysis revealed that the differentially expressed miRNAs and their putative target genes were mainly involved in cell death, cellular development, and cellular growth and proliferation, which are the key regulators for stem cells.23586679
Primary malignant neoplasmEpigenetic AlterationsPathway analysis supported that the miRNAs may regulate signaling associated with induction and maintenance of cancer and stem cell, such as p53, ErbB1, Notch, Wnt, and TGF-b signaling pathways.23586679
Primary malignant neoplasmEpigenetic AlterationsThese data suggest that, in recurrent GBM, growth factor and anti-apoptotic signalings for cancer cell growth and proliferation are regulated by miRNAs.23586679
Colorectal Cancer PathwayEpigenetic AlterationsUpregulation of microRNA-155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin-1 expression.23588589
Addisons disease due to autoimmunityEpigenetic AlterationsMicroRNA expressions in PMBCs, CD4+, and CD8+ T-cells from patients suffering from autoimmune Addisons disease.23589231
Addisons disease due to autoimmunityEpigenetic AlterationsThey extend our very limited knowledge concerning miRNAs in autoimmune Addisons disease.23589231
Bacterial InfectionsEpigenetic AlterationsThe pro-apoptotic miRNA, MIR-15 and MIR-16, were upregulated in cirrhotics with bacterial infections.23590253
Small cell carcinoma of lungEpigenetic AlterationsDNA methylation-mediated repression of miR-886-3p predicts poor outcome of human small cell lung cancer.23592755
Small cell carcinoma of lungEpigenetic AlterationsIn this report, we surveyed 924 miRNA (miR) for their expressions in the formalin-fixed paraffin-embedded specimens from 42 patients with SCLC, and found that the downregulated miR-886-3p is closely correlated with the shorter survival of SCLC.23592755
Chronic Lymphocytic LeukemiaEpigenetic AlterationsWe therefore characterized the epigenetic makeup of 13q14.3 in CLL cells and found histone modifications by chromatin-immunoprecipitation (ChIP) that are associated with activated transcription and significant DNA-demethylation at the transcriptional start sites of DLEU1 and DLEU2 using 5 different semi-quantitative and quantitative methods (aPRIMES, BioCOBRA, MCIp, MassARRAY, and bisulfite sequencing).23593011
Childhood LeukemiaEpigenetic AlterationsEpigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.23593011
NeoplasmsEpigenetic AlterationsWhile no point mutations have been found in the protein coding candidate genes at 13q14.3, they are deregulated in malignant cells, suggesting an epigenetic tumor suppressor mechanism.23593011
NeoplasmsEpigenetic AlterationsThese epigenetic aberrations were correlated with transcriptional deregulation of the neighboring candidate tumor suppressor genes, suggesting a coregulation in cis of this gene cluster.23593011
NeoplasmsEpigenetic AlterationsTherefore, the tumor suppressor mechanism in 13q14.3 underlines the role both of epigenetic aberrations and of lncRNA genes in human tumorigenesis and is an example of colocalization of a functionally related gene cluster.23593011
Anemia, Sickle CellEpigenetic AlterationsExpression of regulatory platelet microRNAs in patients with sickle cell disease.23593351
Anemia, Sickle CellEpigenetic AlterationsWe have identified significant differences in functionally active platelet miRNAs in patients with SCD as compared to controls.23593351
Malignant NeoplasmsEpigenetic AlterationsAberrant expression of microRNA-34a (miR-34a) has been reported to be involved in the tumorigenesis and progression of various classes of malignancies.23593387
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsIn conclusion, miR-34a may act as a tumor suppressor miRNA of HCC.23593387
Malignant tumor of colonEpigenetic AlterationsWe discovered CCAT1, a non-coding RNA over-expressed in colon cancer (CC), but not in normal tissues, thereby making it a potential disease-specific biomarker.23594791
Ulcerative ColitisEpigenetic AlterationsMicroRNA (miRNA) plays an important role in the pathogenesis of UC by regulating the gene expression at the post-transcriptional level and control crucial physiological processes.23595390
Ulcerative ColitisEpigenetic AlterationsAquaporin 8 expression is reduced and regulated by microRNAs in patients with ulcerative colitis.23595390
Ulcerative ColitisEpigenetic AlterationsAQP8 and its relationship with miRNAs may be involved in the pathogenesis of UC.23595390
Squamous cell carcinoma of esophagusEpigenetic AlterationsEpigenetic, genetic and environmental interactions in esophageal squamous cell carcinoma from northeast India.23596512
Squamous cell carcinoma of esophagusEpigenetic AlterationsEsophageal squamous cell carcinoma (ESCC) develops as a result of complex epigenetic, genetic and environmental interactions.23596512
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsEpigenetic changes like, promoter hypermethylation of multiple tumour suppressor genes are frequent events in cancer, and certain habit-related carcinogens are thought to be capable of inducing aberrant methylation.23596512
CarcinogenesisEpigenetic AlterationsDNA methylation, a regulator of gene expression, plays an important role in diverse biological processes including developmental process, carcinogenesis and aging.23599224
Malignant NeoplasmsEpigenetic AlterationsIn particular, aberrant DNA methylation has been largely observed in several types of cancers.23599224
ItalyEpigenetic AlterationsThese results pose a major public health problem, as the epigenetic contribution to these changes, rather than longevity, have serious implications indicating earlier onset of neurological morbidity pressurizing families, health and social care services, with resource implications especially for Australia, Canada, Italy, Netherlands, Spain, the UK and the USA.23601790
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNAs are a class of small noncoding RNAs playing a crucial role in physiological and pathological conditions, including acute myeloid leukemia.23602072
Leukemia, Myelocytic, AcuteEpigenetic AlterationsPatient-specific microRNA expression profiles as a marker for minimal residual disease in acute myeloid leukemia.23602072
Malignant Neoplasms, Malignant neoplasm of thyroidEpigenetic AlterationsMicroRNA (miRNA) expression is deregulated in many types of human cancers, including thyroid cancer.23609190
MetastasisEpigenetic AlterationsThe miRNA microarray results showed that compared to the NLN group, upregulation of four miRNAs including miR-2861, miR-451, miR-193b, and miR-1202 was associated with LN metastasis, whereas four other miRNAs including miR-let-7i, miR-542-5p, miR-664*, and miR-564 were downregulated in the LN group.23609190
Metastasis, F9 geneEpigenetic AlterationsUpregulated expression of miR-2861 and miR-451 in PTC with LN metastasis represents a unique miRNA signature associated with the prognosis and progression of PTC.23609190
Stomach CarcinomaEpigenetic Alterations[Expression of microRNA-100 in human gastric cancer].23611267
Gastrointestinal Stromal SarcomaEpigenetic Alterations[Screening of differentially expressed microRNAs in borderline and malignant gastrointestinal stromal tumors].23611268
Gastrointestinal Stromal TumorsEpigenetic AlterationsThe most significantly expressed 4 miRNAs were then chosen for further validation by real-time PCR in 22 additional GIST samples.23611268
Gastrointestinal Stromal TumorsEpigenetic AlterationsAmong differentially expressed miRNAs, miR-221 and miR-675(*) might be related to the malignant transformation of GISTs, and have a potential value in predicting biological behavior of GISTs.23611268
SepticemiaEpigenetic AlterationsCharacterization and Identification of novel serum microRNAs in sepsis patients with different outcomes.23612084
SepticemiaEpigenetic AlterationsCirculating microRNAs (miRNAs) are an emerging biomarker for sepsis patients.23612084
SepticemiaEpigenetic AlterationsIn conclusion, 41 novel miRNAs were detectable in the sera of sepsis patients, and six of them might be related to sepsis outcome.23612084
Prostate Cancer PathwayEpigenetic AlterationsMicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer.23612742
Metastasis, NeoplasmsEpigenetic AlterationsDecreased expression of the microRNA miR-205 has been observed in multiple tumour types due to its role in the epithelial to mesenchymal transition, which promotes metastasis.23612742
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsDiagnostic and biological significance of microRNA-192 in pancreatic ductal adenocarcinoma.23612862
Clinical Observations Supplemental Qualifiers DatasetEpigenetic AlterationsTo date, no information on microRNA (miRNA) expression in pPCL has been reported.23613318
Chronic Lymphocytic LeukemiaEpigenetic AlterationsBiological and clinical relevance of miRNA expression signatures in primary plasma cell leukemia.23613318
Clinical Observations Supplemental Qualifiers DatasetEpigenetic AlterationsGlobal miRNA expression profiles were analyzed in highly purified malignant plasma cells from 18 pPCL untreated patients included in a prospective clinical trial.23613318
Multiple Myeloma, Clinical Observations Supplemental Qualifiers DatasetEpigenetic AlterationsMiRNA expression was also integrated with gene expression profiles in pPCL and multiple myeloma samples.23613318
Multiple Myeloma, Clinical Observations Supplemental Qualifiers DatasetEpigenetic AlterationsWe identified a series of deregulated miRNAs in pPCL (42 upregulated and 41 downregulated) in comparison with multiple myeloma.23613318
Clinical Observations Supplemental Qualifiers DatasetEpigenetic AlterationsOverall, our study provides insights into the possible contribution of miRNAs in the pathogenesis of pPCL and suggests targets for future therapeutic investigations.23613318
Stomach CarcinomaEpigenetic AlterationsGastric cancer is a biologically heterogeneous disease containing many genetic and epigenetic alterations.23613399
Ischemic strokeEpigenetic AlterationsWe observed that microRNA-424 (miR-424) significantly decreased in an miRNA profile of circulating lymphocytes of patients with ischemic stroke.23613494
Cerebral IschemiaEpigenetic AlterationsMiRNA-424 protects against permanent focal cerebral ischemia injury in mice involving suppressing microglia activation.23613494
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsAdverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network.23620406
Neoplasms, Renal Cell Carcinoma PathwayEpigenetic AlterationsLong non-coding RNA GAS5 functions as a tumor suppressor in renal cell carcinoma.23621190
Cholangiocarcinoma, Metastasis, Primary malignant neoplasmEpigenetic AlterationsMicroRNA-21 regulates the invasion and metastasis in cholangiocarcinoma and may be a potential biomarker for cancer prognosis.23621247
Metastasis, CholangiocarcinomaEpigenetic AlterationsInfluence on cholangiocarcinoma cell line invasion and metastasis was analyzed with microRNA-21 transfected cells.23621247
MetastasisEpigenetic AlterationsIn situ hybridization and real-time quantitative PCR results for patients with lymph node metastasis or perineural invasion showed significantly high expression of microRNA-21 (P<0.05).23621247
Metastasis, CholangiocarcinomaEpigenetic AlterationsThere was a dramatic decrease in cholangiocarcinoma cell line invasion and metastasis ability after microRNA-21 knockdown (P<0.05).23621247
Metastasis, CholangiocarcinomaEpigenetic AlterationsMicroRNA-21 may play an important role in cholangiocarcinoma invasion and metastasis, suggesting that MicroRNA-21 should be further evaluated as a biomarker for predicting cholangiocarcinoma prognosis.23621247
Lupus ErythematosusEpigenetic AlterationsGenome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients.23623029
Lupus ErythematosusEpigenetic AlterationsAbnormal T cell DNA methylation and type-I interferon play an important role in the pathogenesis of lupus.23623029
Lupus ErythematosusEpigenetic AlterationsDNA methylation was quantified for over 485,000 methylation sites across the genome, and differentially methylated sites between lupus patients and controls were identified and then independently replicated.23623029
Abnormal cell, Lupus ErythematosusEpigenetic AlterationsOur data suggest epigenetic "poising" of interferon-regulated genes in lupus naive CD4+ T cells, argue for a novel pathogenic implication for abnormal T cell DNA methylation in lupus, and suggest a mechanism for type-I interferon hyper-responsiveness in lupus T cells.23623029
Lupus ErythematosusEpigenetic AlterationsWe observed significant hypomethylation in interferon-regulated genes in naive CD4+ T cells from lupus patients, including IFIT1, IFIT3, MX1, STAT1, IFI44L, USP18, TRIM22 and BST2, suggesting epigenetic transcriptional accessibility in these genetic loci.23623029
Neoplasms, Glioblastoma MultiformeEpigenetic AlterationsGlioblastoma is one of the most common, lethal and poor clinical outcome primary brain tumors with extraordinarily miscellaneous epigenetic alterations profile.23624749
Glioblastoma MultiformeEpigenetic AlterationsThis study of new epigenetic targets has shown considerably high level of analyzed genes promoter methylation variability in glioblastoma tissue.23624749
NeoplasmsEpigenetic AlterationsThe up-regulated miRNAs (miR-320a, 22 and 129-5p) and down-regulated miRNAs (miR-9, 155 and 640) were confirmed in paclitaxel-resistant FFPE tumor samples, compared with paclitaxel-sensitive samples.23627607
Primary malignant neoplasmEpigenetic AlterationsAberrant expression of miRNAs has emerged as an important hallmark of cancer.23627613
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsEmerging evidence suggests that down-regulated miRNAs play an important role in the carcinogenesis of colorectal cancer (CRC).23628392
Clinical CoordinatorEpigenetic AlterationsSingle nucleotide polymorphisms (SNPs) in the promoter region of miRNAs may disturb miRNAs processing, alter their expression, and ultimately affect an individuals susceptibility to CRC.23628392
cervical cancerEpigenetic AlterationsUpregulation of microRNA-224 is associated with aggressive progression and poor prognosis in human cervical cancer.23631806
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAccumulating evidence for differential expression of microRNA-224 (miR-224) in various types of human cancer suggests that it may be play a crucial role in tumor biology.23631806
cervical cancerEpigenetic AlterationsThe previous microarray detection also shown that miR-224 was one of miRNAs with significant upregulation in cervical cancer tissues relative to adjacent normal tissues.23631806
Malignant NeoplasmsEpigenetic AlterationsEnhancer of zeste homologue 2 (EZH2) plays important roles in epigenetic silencing and cell cycle regulation and is upregulated in a wide variety of malignancies.23636867
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation.23637748
Primary malignant neoplasmEpigenetic AlterationsBy methylation-specific PCR, DNA methylation in the upstream region of miR-219-2-3p was detected in both adjacent normal tissues and cancer tissues.23637748
SERPINB3 wt AlleleEpigenetic AlterationsThe genetic and epigenetic alterations of Epidermal Growth Factor Receptor (EGFR)-RAS-RAF signaling in penile SCC are unclear.23637996
Colorectal Cancer PathwayEpigenetic AlterationsOverexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer.23640607
Prostate Cancer Pathway, ProstateEpigenetic AlterationsProstate cancer-associated ncRNA transcripts 1 (PCAT-1), a lncRNA, has been recently revealed involving in human prostate cancer progression.23640607
Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (lncRNA) are emerging as key molecules in human cancer.23640607
Mantle cell lymphomaEpigenetic AlterationsmicroRNA expression profiles identify subtypes of mantle cell lymphoma with different clinicobiological characteristics.23640973
Medial collateral ligamentEpigenetic AlterationsEnriched targets of these miRNAs corresponded to relevant pathways in MCL pathogenesis such as DNA stress response, CD40 signaling, and chromatin modification.23640973
Acute myocardial infarction, Angina PectorisEpigenetic AlterationsSerum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris.23641832
Malignant tumor of colonEpigenetic AlterationsA microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.23642368
Malignant tumor of colon, NeoplasmsEpigenetic AlterationsHere, we show that the tumor suppressor microRNA miR-34a is a cell-fate determinant in early-stage dividing colon cancer stem cells (CCSCs).23642368
Prostate Cancer Pathway, CTBP1-AS geneEpigenetic AlterationsAndrogen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer.23644382
CTBP1-AS geneEpigenetic AlterationsHere, we report an androgen-responsive long ncRNA, CTBP1-AS, located in the AS region of C-terminal binding protein 1 (CTBP1), which is a corepressor for androgen receptor.23644382
Stomach CarcinomaEpigenetic AlterationsDecreased expression of long noncoding RNA AC096655.1-002 in gastric cancer and its clinical significance.23645148
Liver carcinoma, Hollings Cancer Center, Neoplasm MetastasisEpigenetic AlterationsWe previously reported that miR-185 is associated with hepatocellular carcinoma (HCC) venous metastasis analysed by miRNA-array profile.23648054
Leukemia, Myelocytic, AcuteEpigenetic AlterationsClinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients.23650424
Transitional cell carcinoma of bladder, UBC geneEpigenetic AlterationsUrothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological, genetic, and epigenetic levels.23650517
Autoimmune DiseasesEpigenetic AlterationsModification of the expression of specific microRNAs (miRNAs) has been associated with different autoimmune diseases and/or LPDs.23650540
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-424-5p suppresses the expression of SOCS6 in pancreatic cancer.23653113
Malignant Neoplasms, Pancreatic carcinomaEpigenetic AlterationsThe expression of microRNA-424-5p (miR-424-5p) has been shown to vary in multiple hematological and solid organ malignancies, such as pancreatic cancer.23653113
Chronic heart failureEpigenetic AlterationsMicroRNAs (miRNAs) are widely involved in the process of chronic heart failure (HF), which is characterized by reactivation of the fetal gene program.23660476
Gallbladder Carcinoma, Aggressive behaviorEpigenetic AlterationsHigh expression of microRNA-155 is associated with the aggressive malignant behavior of gallbladder carcinoma.23660842
VHL protein, human, Neurofibromatosis 1, Oncogene, RET, NeoplasmsEpigenetic AlterationsThrough characterization of miRNA profiles in 69 frozen tumors with germline mutations in the genes SDHD, SDHB, VHL, RET, NF1, TMEM127, and MAX, we identified miRNA signatures specific to, as well as common among, the genetic groups of PCCs/PGLs.23660872
Primary malignant neoplasmEpigenetic AlterationsSince methylation of tumor-derived DNA can be detected in the serum of cancer patients, this makes DNA methylation-based biomarkers one of the most promising diagnostic strategies.23661397
Admitting diagnosis, Traumatic, "Alzheimers Disease", Traumatic Brain InjuryEpigenetic AlterationsTraumatic brain injury (TBI) is an epigenetic risk factor for Alzheimers disease (AD) and amyloid b (Ab) deposition is observed histopathologically in the traumatized brain.23662609
Multiple MyelomaEpigenetic Alterations[Expression level of microRNA-92a and its clinical significance in multiple myeloma patients].23668207
Adrenocortical carcinomaEpigenetic AlterationsDeregulation of microRNA (miRNA) expression in adrenocortical carcinomas (ACCs) has been documented to have diagnostic, prognostic, as well as functional implications.23671264
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is an important epigenetic modification and is frequently altered in cancer.23671639
Metastasis, AscitesEpigenetic AlterationsA significant up-regulation of miRNA-21 and miRNA-214 was observed in malignant cells of ascites compared to omental metastasis; this was confirmed by both cell viability assay and RT-q-PCR.23672416
Metastasis, Neoplasms, AscitesEpigenetic AlterationsOurs is the first report that demonstrates significant up-regulation of miRNA-21 and miRNA-214 in tumor cells from ascites of patients with EOC compared to omental metastasis.23672416
Resistance Process, ovarian neoplasmEpigenetic AlterationsChemoresistance in ovarian cancer linked to expression of microRNAs.23672416
Colorectal Cancer PathwayEpigenetic AlterationsmicroRNA expression profile in stage III colorectal cancer: circulating miR-18a and miR-29a as promising biomarkers.23673725
Primary malignant neoplasmEpigenetic AlterationsThe deregulation of miRNA expression has been found in several types of cancer and may represent a novel class of cancer biomarkers.23673725
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsOur aim was to determine the miRNA signature of stage III colorectal cancer (CRC) tumors and to identify potential circulating miRNAs that may represent non-invasive biomarkers in CRC patients.23673725
Clinical CoordinatorEpigenetic AlterationsA selection of differentially overexpressed miRNAs was validated by quantitative real-time polymerase chain reaction (qRT-PCR) and determined in the serum of a set of 56 individuals (30 stage III CRC patients and 26 healthy individuals).23673725
Clinical CoordinatorEpigenetic AlterationsWe were able to detect 9 of these 11 miRNAs in serum samples from CRC patients and healthy individuals.23673725
Clinical CoordinatorEpigenetic AlterationsMoreover, the findings provide relevant information concerning overexpressed tumoral miRNAs as potential circulating biomarkers and highlight serum miR-18a and miR-29a as promising biomarkers for the screening and monitoring of CRC patients.23673725
Breast CarcinomaEpigenetic AlterationsDNA methylation of tumor-suppressor genes occurs early in the molecular transformation of precursor events to breast cancer and is therefore of interest to screening in high-risk women.23674191
Primary malignant neoplasmEpigenetic AlterationsThe frequency of target gene DNA methylation in tissue and DL of cancer and healthy control patients was assessed, and an association of DNA methylation between different duct systems in the same breast was explored.23674191
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTumor, adjacent tissue and bilateral DL samples for comparative DNA methylation studies were obtained during surgery from women with cancer.23674191
SCGB3A1 gene, Primary malignant neoplasmEpigenetic AlterationsThe sensitivity of DNA methylation in DL samples compared with matched cancer tissue was highest for SCGB3A1 (90 %), CDH13 (91 %), and RARB (83 %).23674191
Primary malignant neoplasmEpigenetic AlterationsThe genetic algorithm selected RASSF1A, RARB, and IGFBP7 as the optimum predictor set for detecting DNA methylation in cancer tissue.23674191
Primary malignant neoplasmEpigenetic AlterationsThe optimum area under the ROC curve for DNA methylation in cancer compared with internal control healthy tissue from excision margins was 0.84.23674191
Primary malignant neoplasmEpigenetic AlterationsThe area under the ROC curve for DNA methylation in cancer DL compared with contralateral benign DL was 0.76.23674191
Breast CarcinomaEpigenetic AlterationsThe approach of DNA methylation in DL may be substantiated by a larger trial of breast cancer biomarkers.23674191
Myeloid Leukemia, ChronicEpigenetic AlterationsProtein-coding genes and long noncoding RNAs are differentially expressed in dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib.23676950
Esophageal carcinomaEpigenetic AlterationsWe report the emerging role of microRNA (miRNA) deregulation associated with activation of an oncogene SOX4 (a member of the SRY-related HMG-box) in esophageal carcinoma.23677061
Primary malignant neoplasmEpigenetic AlterationsRestoration of miR-129-2 by transfection with an miRNA expression plasmid led to a decrease in SOX4 expression, which was accompanied by reduced migration and proliferation of the cancer cells.23677061
Esophageal carcinomaEpigenetic AlterationsOur results demonstrated that the deregulation of miR-129-2 leads to aberrant SOX4 expression, presenting a new paradigm in which the restoration of miRNA suppresses its oncogenic target in esophageal cancer.23677061
Metastasis, NeoplasmsEpigenetic AlterationsThe discovery that microRNAs (miRNAs) regulate proliferation, invasion and metastasis provides a principal molecular basis of tumor heterogeneity.23679262
NeoplasmsEpigenetic AlterationsMiRNAs can regulate gene expression, cell growth, differentiation and apoptosis by targeting mRNAs for translational repression or degradation in tumor cells.23679328
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsAberrant DNA methylation at CpG islands within promoters is increasingly recognised as a common event in human cancers and has been associated with the silencing of important tumour suppressor genes.23679560
SF3B1 wt AlleleEpigenetic AlterationsEpigenetic therapy using hypomethylating agents has demonstrated clinical effectiveness; the drugs azacitidine and decitabine have been approved for the treatment of MDS.23679560
Malignant neoplasm of urinary bladder, Malignant Neoplasms, NeoplasmsEpigenetic AlterationsBladder cancer like other cancers arises from the accumulation of many genetic and epigenetic changes that lead to the activation of proto-oncogenes or inactivation of tumor suppressor genes.23682613
Neoplasms, HereditaryEpigenetic AlterationsNo significant differences in miRNA expression were found between RET mutation positive and negative tumors nor between sporadic and hereditary tumors.23685355
NeoplasmsEpigenetic AlterationsMicroRNAs are a primordial mechanism of gene expression control that appear to be crucial to cellular development and may play an important role in tumor development.23685355
Carcinoma of lungEpigenetic AlterationsIn human (HOP62, H522, and H23) and murine transgenic (ED-1, ED-2, LKR-13, and 393P, driven, respectively, by cyclin E, degradation-resistant cyclin E, KRAS, or KRAS/p53) lung cancer cell lines, vorinostat reduced growth, cyclin D1, and cyclin E levels, but induced p27, histone acetylation, and apoptosis.23686769
Chronic active Epstein-Barr virus infectionEpigenetic AlterationsPlasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection.23687223
Epstein-Barr Virus InfectionsEpigenetic AlterationsLevels of specific plasma EBV miRNAs were elevated differentially in patients with CAEBV infection.23687223
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miRNA) deregulation is associated with progression and treatment outcome in various types of cancers.23689423
Leukemia, Myelomonocytic, Chronic, JAK2 protein, human, nucleophosmin, NRAS gene, KRAS protein, humanEpigenetic AlterationsWe genotyped ASXL1 and up to 18 other genes including epigenetic (TET2, EZH2, IDH1, IDH2, DNMT3A), splicing (SF3B1, SRSF2, ZRSF2, U2AF1), transcription (RUNX1, NPM1, TP53), and signaling (NRAS, KRAS, CBL, JAK2, FLT3) regulators in 312 patients with CMML.23690417
Clinical CoordinatorEpigenetic AlterationsMiRNAs were profiled by TaqMan MicroRNA Array and screened for differential expression in 5 pools of plasma samples of CRC patients (N = 50) and 5 pools of neoplasm-free controls (N = 50).23690963
Colorectal Cancer PathwayEpigenetic AlterationsIdentification and evaluation of plasma microRNAs for early detection of colorectal cancer.23690963
Clinical CoordinatorEpigenetic AlterationsCirculating microRNAs (miRNAs) have been suggested as potentially promising markers for early detection of CRC.23690963
Clinical CoordinatorEpigenetic AlterationsNine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples.23690963
AdenomaEpigenetic AlterationsNone of the selected miRNAs showed significant differential expression between advanced adenoma patients and neoplasm-free controls.23690963
Clinical CoordinatorEpigenetic AlterationsThe identified panel of miRNAs could be of potential use in the development of a multi-marker blood based test for early detection of CRC.23690963
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation biomarkers for noninvasive diagnosis of colorectal cancer.23694962
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation biomarkers for noninvasive diagnosis of colorectal cancer (CRC) and precursor lesions have been extensively studied.23694962
Neoplastic disease, Inflammatory Bowel DiseasesEpigenetic AlterationsMoreover, our panel may complement histologic and endoscopic diagnosis of inflammatory bowel disease (IBD)-associated neoplasia, as it was also efficient detecting aberrant DNA methylation in non-neoplastic tissue samples from affected patients.23694962
Breast CarcinomaEpigenetic AlterationsDecreased expression of microRNA-206 in breast cancer and its association with disease characteristics and patient survival.23696595
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-206 (miR-206) is downregulated in many human malignancies, which correlates with tumour progression.23696595
Heart failureEpigenetic AlterationsCirculating microRNAs as candidate markers to distinguish heart failure in breathless patients.23696613
Cardiovascular DiseasesEpigenetic AlterationsSince their identification in the circulation, microRNAs have received considerable interest as putative biomarkers of cardiovascular disease.23696613
Chronic Obstructive Airway DiseaseEpigenetic AlterationsSeventeen microRNAs were selected for validation in 44 HF, 32 COPD, 59 other breathless, and 15 controls.23696613
NeoplasmsEpigenetic AlterationsEpigenetic events, including covalent post-translational modifications of histones, have been demonstrated to have critical roles in tumor development and progression.23698071
Sample Size CalculationEpigenetic AlterationsAberrant epigenetic modifications also contribute to the persistent activation of SSc fibroblasts.23698475
Sample Size CalculationEpigenetic AlterationsWe investigated whether increased Wnt signalling and epigenetic changes in SSc are causally linked via promoter hypermethylation-induced silencing of Wnt antagonists.23698475
Sample Size CalculationEpigenetic AlterationsThese data provide a novel link between epigenetic alterations and increased Wnt signalling in SSc and also have translational implications because Dnmt inhibitors are already approved for clinical use.23698475
NeoplasmsEpigenetic AlterationsCombining DNA methylation and gene expression data led to the identification of the epigenetically regulated tumor modulating genes GPX3, RBP1, SPARC, and TGFBI.23699600
Multiple MyelomaEpigenetic AlterationsAssessment of the DNA methylation status of the identified genes could contribute to the molecular characterization of myeloma, which is prerequisite for an individualized treatment approach.23699600
Malignant neoplasm of endometriumEpigenetic AlterationsThese observations suggest that ARID1A is a causative gene, instead of a target gene, of microsatellite instability by having a role in epigenetic silencing of the MLH1 gene in endometrial cancer.23702729
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsResults from the present explorative study suggest that quantitative epigenetic classification of rectal cancer by MS-MLPA clearly distinguishes tumor tissue from apparently normal mucosa.23702823
Clinical Coordinator, AdenomaEpigenetic AlterationsWe validated expression of candidate miRNAs in serum samples from an independent cohort of 186 CRC patients, 60 postoperative patients, 43 advanced adenoma patients, and 53 control subjects.23704278
Clinical CoordinatorEpigenetic AlterationsWe analyzed miR-21 expression in 166 matched primary CRC tissues to determine whether serum miRNAs reflect expression in CRC.23704278
Neurodegenerative Disorders, Antilymphocyte SerumEpigenetic AlterationsConsidering that miRNAs are increasingly being recognized as having a role in a variety of neurodegenerative diseases, we decided to characterize the miRNA expression profile in spinal cord (SC) tissue in sporadic ALS (sALS) and controls.23705811
Cerebrovascular accident, Impaired cognition, nervous system disorderEpigenetic AlterationsEuropean Leukodystrophies Association, INSERM and Assistance Publique-Hopitaux de Paris, Dutch Organisation for Scientific Research (ZonMw), E-Rare, Hersenstichting, Optimix Foundation for Scientific Research, Myelin Disorders Bioregistry Project, National Institute of Neurological Disorders and Stroke, and Genetic and Epigenetic Networks in Cognitive Dysfunction (GENCODYS) Project (funded by the European Union Framework Programme 7).23707145
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsEpigenetic silencing was particularly severe in SDHB-mutated tumors, potentially explaining their malignancy.23707781
Heart failure, Coronary Artery DiseaseEpigenetic AlterationsCoronary artery disease (CAD)-associated ischemic heart failure is characterized by dysregulated gene expression which is partly mediated by microRNAs (miRNAs).23711953
Pancreatic carcinomaEpigenetic AlterationsThe regulation of Mut L homologue 1 (MLH1) expression by microRNA (miR)-155 and its prognostic significance in pancreatic cancer (PC) remain to be elucidated.23715647
Kidney Failure, AcuteEpigenetic AlterationsMicroRNA-21 and risk of severe acute kidney injury and poor outcomes after adult cardiac surgery.23717419
Gastrointestinal Stromal TumorsEpigenetic AlterationsPost-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST].23717541
Gastrointestinal Stromal TumorsEpigenetic AlterationsA cluster of miRNAs on 14q32 show strikingly different expression patterns amongst GISTs, a finding which appears to be explained at least in part by differential allelic methylation of this imprinted region.23717541
Bladder NeoplasmEpigenetic AlterationsAlso, our results suggest interesting differentially regulated miRNA-mRNA interactions associated with bladder tumor progression.23717626
Primary malignant neoplasmEpigenetic AlterationsIt has been proposed that miRNAs play an important role in cancer development and progression.23717626
Primary malignant neoplasmEpigenetic AlterationsFurther analysis reveals genes identified as differentially regulated by miRNAs to be enriched in cancer pathways, thus suggesting biologically interesting interactions.23717626
Chronic Kidney DiseasesEpigenetic AlterationsDecreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD).23717629
Chronic Kidney DiseasesEpigenetic AlterationsIn conclusion, we have found ex vivo and in vitro evidence for decreased expression of these vascular miRNA in CKD, suggesting that alterations in miRNAs may lead to the synthetic state of VSMC found in CKD.23717629
Vascular smooth muscle cellEpigenetic AlterationsMicroRNAs (miRNAs) control mRNA expression intracellularly and are secreted into the circulation; three miRNAs (miR-125b, miR-145 and miR-155) are known to alter vascular smooth muscle cell (VSMC) proliferation and differentiation.23717629
Multiple MyelomaEpigenetic AlterationsImproved risk stratification in myeloma using a microRNA-based classifier.23718138
Colorectal CarcinomaEpigenetic AlterationsMicroRNAs (miRNA) have potential prognostic value for colorectal cancers; however, their value based on patient race/ethnicity and pathologic stage has not been determined.23719259
Colorectal Cancer PathwayEpigenetic AlterationsThe prognostic value of microRNAs varies with patient race/ethnicity and stage of colorectal cancer.23719259
African AmericanEpigenetic AlterationsThe goal was to ascertain the prognostic value of 5 miRNAs with increased expression in colorectal cancers of African American (black) and non-Hispanic Caucasian (white) patients.23719259
Colorectal CarcinomaEpigenetic AlterationsAll 5 miRNAs had higher expression in colorectal cancers (>1.0-fold) than in corresponding normal tissues.23719259
Colorectal CarcinomaEpigenetic AlterationsThese preliminary findings suggest that the prognostic value of miRNAs in colorectal cancers varies with patient race/ethnicity and stage of disease.23719259
Pancreatic carcinomaEpigenetic AlterationsMicroRNA gene polymorphisms in pancreatic cancer.23719600
Pancreatic NeoplasmEpigenetic AlterationsOur findings suggested that the rs2910164 and rs11614913 SNPs might play a role in pancreatic tumorigenesis, but the molecular mechanism underlying the particular sequence variations in miRNA that can cause aberrant expression remains to be determined.23719600
Malignant neoplasm of urinary bladderEpigenetic AlterationsThese findings suggest that the relative low expression of miRNA-34a might be involved in the tumorigenesis of bladder cancer.23720881
HIVEpigenetic AlterationsMicroRNA regulation and its effects on cellular transcriptome in human immunodeficiency virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts.23721325
Communicable DiseasesEpigenetic AlterationsSelected miRNA and mRNA transcripts were validated using in vivo and in vitro infection model.23721325
Neoplasms, Renal Cell Carcinoma PathwayEpigenetic AlterationsEpigenetic alterations of Kruppel-like factor 4 and its tumor suppressor function in renal cell carcinoma.23722653
Renal Cell Carcinoma PathwayEpigenetic AlterationsThe purpose of this study is to determine epigenetic alterations and possible roles of KLF4 in renal cell carcinoma.23722653
Malignant Neoplasms, MIR20A geneEpigenetic AlterationsMicroRNA- 20a (miR-20a) and microRNA-203 (miR-203) have previously shown significant alteration in a range of cancers.23725129
cervical cancerEpigenetic AlterationsWe propose that miRNAs might be used as therapeutic agents for cervical cancer.23725129
Hodgkin DiseaseEpigenetic AlterationsMicroRNA signatures and treatment response in patients with advanced classical Hodgkin lymphoma.23725219
Hodgkin DiseaseEpigenetic AlterationsAlthough specific microRNA (miRNA) signatures in classical Hodgkin lymphoma (cHL) have been proposed, their relationship with clinical outcome remains unclear.23725219
MIR21 gene, doxorubicinEpigenetic AlterationsAdditionally, functional silencing of MIR21 and MIR30D in L428 cells showed increased sensitivity to doxorubicin-induced apoptosis, pointing towards abnormalities of mitochondrial intrinsic and TP53-CDKN1A pathways as related to miRNA deregulation in cHL.23725219
Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsSerum levels of miRNAs, miR-21, miR-34a, miR-122, and miR-451 were higher in participants with NAFLD.23727030
Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsSerum levels of miRNAs, particularly miR-122, may be a useful biomarker for NAFLD.23727030
Endometrial Carcinoma, Primary malignant neoplasmEpigenetic AlterationsWe analyzed more than 27,000 CpGs in normal endometrial tissue (n = 23) and endometrial cancers (n = 64) and found that DNA methylation of GALR1 is among the most frequent epigenetic alterations in this cancer.23727823
Malignant Neoplasms, Malignant neoplasm of endometrium, Postmenopausal bleedingEpigenetic AlterationsThe receiver operating characteristics area under the curve, describing sensitivity and specificity to correctly identify the 41 women with both premalignant and malignant endometrial changes, was 0.93 (95% confidence interval, 0.87-0.97; P < 0.0001).GALR1 DNA methylation is one of the most common molecular alterations in endometrial cancer, and the presence of GALR1 methylation in vaginal swabs from women with postmenopausal bleeding indicates the presence of endometrial malignancy with a sensitivity of 92.7% and a specificity of 78.9%.23727823
NeoplasmsEpigenetic AlterationsWe show that ZBTB7A physically interacts with SOX9 and functionally antagonizes its transcriptional activity on key target genes such as MIA, which is involved in tumor cell invasion, and H19, a long noncoding RNA precursor for an RB-targeting microRNA.23727861
Malignant neoplasm of larynxEpigenetic AlterationsGlobal DNA methylation status in laryngeal cancer.23729003
Malignant neoplasm of endometriumEpigenetic AlterationsMicroRNA-503 suppresses proliferation and cell-cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1.23731275
InitiationEpigenetic AlterationsMicroRNAs (miRNAs) are post-transcriptional inhibitor regulators of gene expression that act by directly binding complementary mRNA and are key determinants of cancer initiation and progression.23731275
Stomach CarcinomaEpigenetic AlterationsMiRNA-199a-3p: A potential circulating diagnostic biomarker for early gastric cancer.23733518
Stomach DiseasesEpigenetic AlterationsThe expression of miRNA-199a-3p (47.5 +- 6.5) in plasma in EGC patients was significantly higher than that from healthy controls (13.9 +- 2.7, P < 0.001) and gastric precancerous diseases (GPD) patients (19.2 +- 2.5, P = 0.004), respectively.23733518
NeoplasmsEpigenetic AlterationsWith respect of clinicopathological characteristics, the expression of miRNA-199a-3p in plasma was not associated with the depth of tumor invasion.23733518
NeoplasmsEpigenetic AlterationsMoreover, the AUC of the expression of miRNA-199a-3p in plasma for EGC diagnosis was 0.818, which was significantly higher than that of combined tumor markers (0.556).23733518
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met.23734217
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNA-449a is expressed at a low level in several tumors and cancer cell lines, and induces G1 arrest, apoptosis, and senescence.23734217
Ulcerative ColitisEpigenetic AlterationsBased on these preliminary findings, diagnostic markers based on differential DNA methylation at specific loci can be useful for non-invasive and reliable detection of UC and epigenetic field defect.23735005
Hypertrophy, Fibrosis AssessmentEpigenetic AlterationsIn responders, reverse remodelling is associated with favourable changes in miRNAs that regulate cardiac fibrosis, apoptosis, and hypertrophy.23736534
NeoplasmsEpigenetic AlterationsEpigenetic changes are considered to be a frequent event during tumor development.23736679
Malignant neoplasm of endometrium, CarcinogenesisEpigenetic AlterationsThe findings suggest the importance of hypermethylation of CDH13, WT1 and GATA5 genes in endometrial carcinogenesis and could have implications for future diagnostic and therapeutic strategies of endometrial cancer based on epigenetic changes.23736679
Primary malignant neoplasmEpigenetic AlterationsCancer is a multifactorial disease composed of cells that show somatic mutations and epigenetic changes.23738964
Antilymphocyte SerumEpigenetic AlterationsTherefore, antisense oligonucleotides may be used to successfully inhibit miRNAs throughout the brain and spinal cord, and miR-155 is a promising new therapeutic target for human ALS.23740943
Malignant tumor of colonEpigenetic AlterationsDiagnostic microRNA markers to screen for sporadic human colon cancer in stool: I.23741026
Tetranitromethane, Malignant tumor of colonEpigenetic AlterationsTwelve of the miRNAs exhibited increased and 8 decreased expression in stool from 60 individuals (20 controls, 20 with tumor-lymph node-metastatic (TNM) stage 0-1, 10 with stage 2, five with stage 3, and 5 with stage 4 colon cancer) to quantitatively monitor miRNA changes at various TNM stages of colon cancer progression.23741026
Malignant tumor of colonEpigenetic AlterationsThe performance characteristics of the test confirmed that stool is a medium well-suited for colon cancer screening, and that the quantitative changes in the expression of few mature miRNA molecules in stool associated with colon cancer progression provided for more sensitive and specific non-invasive diagnostic markers than tests currently available on the market.23741026
Malignant tumor of colon, MIR20A gene, Adenoma, CarcinomaEpigenetic AlterationsResults of the PCR analyses confirmed that twelve miRNAs (miR-7, miR-17, miR-20a, miR-21, miR-92a, miR-96, miR-106a, miR-134, miR-183, miR-196a, miR-199a-3p and miR214) had an increased expression in the stool of patients with colon cancer, and that later TNM carcinoma stages exhibited a more pronounced expression than did adenomas.23741026
Malignant tumor of colon, TetranitromethaneEpigenetic AlterationsOn the other hand, eight miRNAs (miR-9, miR-29b, miR-127-5p, miR-138, miR-143, miR-146a, miR-222 and miR-938) had decreased expression in the stool of patients with colon cancer, which was also more pronounced from early to later TNM stages.23741026
Aggressive behavior, Non-Small Cell Lung CarcinomaEpigenetic AlterationsLarge noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer.23743197
Malignant Neoplasms, MetastasisEpigenetic AlterationsHOTAIR is one of long non-coding RNAs and its expression correlates with the prognosis and metastasis in various cancers.23743197
ovarian neoplasm, Neoplasms, Cessation of lifeEpigenetic AlterationsOvarian cancer is the leading cause of death from gynaecologic tumours, but the molecular and especially epigenetic events underlying the transformation are poorly understood.23746174
ovarian neoplasmEpigenetic AlterationsTo search for epigenetic events we used methylation-specific multiplex ligation-dependent probe amplification to compare the methylation status of 44 tissue samples of ovarian cancer with 30 control samples.23746174
ovarian neoplasmEpigenetic AlterationsThese findings could potentially be used in screening of ovarian cancer, and may have implications for future chemotherapy based on epigenetic changes.23746174
Aortic Aneurysm, AbdominalEpigenetic AlterationsIdentification and characterization of microRNAs in vascular smooth muscle cells from patients with abdominal aortic aneurysms.23746831
Cardiovascular DiseasesEpigenetic AlterationsThe role of microRNAs (miRs) in the development of various cardiovascular diseases was recently highlighted in several studies.23746831
Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation has shown promise as a biomarker for the early detection of cancer.23747112
HypertrophyEpigenetic AlterationsRelease kinetics of circulating muscle-enriched microRNAs in patients undergoing transcoronary ablation of septal hypertrophy.23747779
Cardiovascular DiseasesEpigenetic AlterationsmiRNAs may be useful as novel biomarkers in patients with cardiovascular disease, although it is difficult to establish the detailed release kinetics of miRNAs in patients with AMI.23747779
NeoplasmsEpigenetic AlterationsMicroRNAs (miRs) are small, noncoding RNAs that target genes involved in tumor development and progression.23748853
NeoplasmsEpigenetic AlterationsUsing quantitative TaqMan MicroRNA PCR, we measured the relative concentrations of 6 circulating microRNAs (miR-10b, -17, -34a, -93, -155, and -373) known to be relevant for tumor development and progression.23748853
Breast Cancer CellEpigenetic AlterationsDeregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression.23748853
Breast CarcinomaEpigenetic AlterationsOur findings indicate that serum concentrations of deregulated microRNAs may be linked to a particular biology of breast carcinomas favoring progression and metastatic spread.23748853
Stomach CarcinomaEpigenetic AlterationsDownregulation of microRNA-206 is a potent prognostic marker for patients with gastric cancer.23751352
Breast Carcinoma, Malignant neoplasm of larynx, Neoplasms, Malignant Neoplasms, Carcinoma of lung, Rhabdomyosarcoma, Glioblastoma Multiforme Pathway, Endometrial Endometrioid AdenocarcinomaEpigenetic AlterationsMicroRNA-206 (miR-206), as a homolog of miR-1, plays important roles in tumorigenesis and tumor progression of various human malignancies, including breast cancer, endometrial endometrioid carcinoma, rhabdomyosarcoma, glioma, lung cancer, and laryngeal cancer.23751352
NeoplasmsEpigenetic AlterationsThe high relative stability of miRNAs in biofluids such as plasma and serum, and the ability of miRNA expression profiles to accurately classify discrete tissue types and disease states have positioned miRNAs as promising non-invasive new tumor biomarkers.23756108
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsDeregulation of miRNAs expression levels has been detected in many human tumor types, and recent studies have demonstrated the critical roles of miRNAs in cancer pathogenesis.23756108
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe further validated our results by RT-qPCR for differentially expressed miRNAs in an independent group of 40 matched fresh frozen tissues, 37 plasma samples from NSCLC patients and 28 healthy donors.23756108
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHowever, in NSCLC plasma samples, only three of these miRNAs (miR-21, miR-10a, and miR-30e-5p) displayed differential expression when compared to plasma of healthy donors.23756108
Colorectal Cancer PathwayEpigenetic AlterationsPotentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer.23758639
Clinical CoordinatorEpigenetic AlterationsThe triple miRNA classifier of miR-193a-3p, miR-23a and miR-338-5p appears to be a potential blood biomarker for early detection of CRC.23758639
Primary malignant neoplasmEpigenetic AlterationsCirculating blood miRNAs offer great potential as cancer biomarkers.23758639
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsThe objective of this study was to correlate the differential expression of miRNAs in tissue and blood in the identification of biomarkers for early detection of colorectal cancer (CRC).23758639
Immune dysregulationEpigenetic AlterationsDysregulations in circulating blood miRNAs are reflective of those in colorectal tissues.23758639
Non-Small Cell Lung CarcinomaEpigenetic AlterationsBCL11A overexpression predicts survival and relapse in non-small cell lung cancer and is modulated by microRNA-30a and gene amplification.23758992
Non-Small Cell Lung CarcinomaEpigenetic AlterationsData from array-based Comparative Genomic Hybridization (aCGH) and microRNA transfection experiments were integrated to explore the potential mechanisms of abnormal BCL11A activation in NSCLC.23758992
Adenocarcinoma of lung (disorder), Squamous cell carcinoma of lungEpigenetic AlterationsIdentification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma.23759980
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese newly identified miRNAs may prove to be highly valuable molecular markers for the classification of NSCLC histological subtypes and may contribute to the pathogenesis of each subtype of NSCLC.23759980
MIRN548 microRNA, humanEpigenetic AlterationsThis resulted in loss of 9 out of 14 miRNA binding sites (hsa-miR-548 family), despite the significant overexpression of miR548a-5p and miR548d-5p among such cases (28.64 and 36.25 folds, respectively), in comparison to HPV negative control samples.23762404
Liver carcinomaEpigenetic AlterationsMicroRNA-22 expression in hepatocellular carcinoma and its correlation with ezrin protein.23766411
Liver carcinoma, Hollings Cancer Center, NeoplasmsEpigenetic AlterationsHepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes.23766440
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsIn human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity.23766440
Endothelial dysfunctionEpigenetic AlterationsMiR-21, a multiple-functional miRNA, was evidenced to be involved in endothelial dysfunction, however, the underlying molecular mechanisms were still unknown.23771797
Adenoid Cystic Carcinoma, NeoplasmsEpigenetic AlterationsThe expression of some miRNAs differed in the tumor tissues compared to their controls: the let-7b was overexpressed in salivary gland-derived adenoid cystic carcinoma, while decreased in breast-derived adenoid cystic carcinoma.23774803
Adenoid Cystic CarcinomaEpigenetic AlterationsThrough post-transcriptional regulation of the genes, the diverse expression of some miRNAs may partially explain the diverse clinical outcome of salivary gland-derived and breast-derived adenoid cystic carcinomas.23774803
Colorectal CarcinomaEpigenetic AlterationsAn essential microRNA maturing microprocessor complex component DGCR8 is up-regulated in colorectal carcinomas.23775303
Clinical Coordinator, Immune dysregulation, Carcinogenesis, Colorectal Cancer PathwayEpigenetic AlterationsDysregulations in the miRNA machinery may be involved in carcinogenesis of colorectal cancer (CRC).23775303
AncrivirocEpigenetic AlterationsFirst, we employed Illumina deep sequencing for the initial screening to indicate the read numbers of miRNA expression in 10 PBC, 5 CH-C, 5 CH-B patients and 5 healthy controls.23776611
AncrivirocEpigenetic AlterationsThe heat map and hierarchical clustering demonstrated that the miRNA profiles from PBC clustered with those of CH-B, CH-C and healthy controls.23776611
Primary Biliary CholangitisEpigenetic AlterationsDistinct microRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers.23776611
Non-Small Cell Lung CarcinomaEpigenetic AlterationsOverexpression of miRNA-21 promotes radiation-resistance of non-small cell lung cancer.23777591
Primary malignant neoplasmEpigenetic AlterationsMiRNA-21 was previously reported to be up-regulated in many kinds of cancer.23777591
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA-21 expression increased in non-small cell lung cancer.23777591
MetastasisEpigenetic AlterationsExpression of miRNA-21 was positively associated with lymph node metastasis, clinical stage and poor prognosis.23777591
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA-21 may be considered as a potential novel target for future development of specific therapeutic interventions in NSCLC.23777591
Malignant Neoplasms, Cancer-Related DeathEpigenetic AlterationsChemo-resistance is one of the key causal factors in cancer death and emerging evidences suggest that microRNAs (miRNAs) have critical roles in the regulation of chemo-sensitivity in cancers.23778521
Cessation of lifeEpigenetic AlterationsThe mucin phenotype and expression of microRNA-21 (miR-21) and programmed cell death protein 4 (PDCD4) were also analysed.23778530
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsInvolvements of microRNA-22 (miR-22) in cancer development have attracted much attention, but its role in tumorigenesis of gastric cancer is still largely unknown.23786758
Liver carcinomaEpigenetic AlterationsEpigenetic silencing of DACH1 induces loss of transforming growth factor-b1 antiproliferative response in human hepatocellular carcinoma.23787902
CarcinogenesisEpigenetic AlterationsEpigenetic mechanisms have important roles in carcinogenesis.23788032
Carcinogenesis, Colorectal Cancer PathwayEpigenetic AlterationsThese molecular pathological epidemiology data suggest a protective effect of smoking cessation on a DNA methylation-related carcinogenesis pathway leading to CIMP-high colorectal cancer.23788674
FRAGILE X TREMOR/ATAXIA SYNDROMEEpigenetic AlterationsMicroRNA expression profiling in blood from fragile X-associated tremor/ataxia syndrome patients.23790110
Neurodegenerative DisordersEpigenetic AlterationsSince the identification of the first microRNAs (miRNAs) and their role in normal development, several studies have associated them with neurodegenerative diseases such as Parkinson, Alzheimer and Huntington diseases, suggesting that they play a key role in brain development, as well as in its morphogenesis.23790110
FRAGILE X TREMOR/ATAXIA SYNDROMEEpigenetic AlterationsWhen comparing these results, 14 miRNAs were found deregulated in FXTAS patients.23790110
Malignant Neoplasms, Breast Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-7 (miR-7) has been described as a tumor suppressor in several human cancers, but the results of a study to identify miRNAs associated with metastatic capability in breast cancer suggested that miR-7 may be characterized as an oncogene.23793934
Renal Cell Carcinoma, Refractory Cytopenia of ChildhoodEpigenetic AlterationsQuantitative real-time polymerase chain reaction was used to validate the expressions of miR-7 in 48 paired renal cell carcinomas (RCC) and normal tissues, based on the preliminary sequencing results of miRNAs.23793934
Breast CarcinomaEpigenetic AlterationsIdentification of circulating microRNA signatures for breast cancer detection.23797906
Mammary NeoplasmsEpigenetic AlterationsmiRNA from paired breast cancer tumors, normal tissue, and serum samples derived from 32 patients were comprehensively profiled using microarrays or locked nucleic acid real-time PCR panels.23797906
Breast Carcinoma, Mammary NeoplasmsEpigenetic AlterationsThe 20 most significant miRNAs differentially expressed in breast cancer tumors included miRNA (miR)-21, miR-10b, and miR-145, previously shown to be dysregulated in breast cancer.23797906
Malignant neoplasm of breastEpigenetic AlterationsThe clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different subtypes of breast cancers.23797906
NeoplasmsEpigenetic AlterationsOnly 7 miRNAs were overexpressed in both tumors and serum, suggesting that miRNAs may be released into the serum selectively.23797906
Prostate Cancer PathwayEpigenetic AlterationsDistinct microRNA expression profile in prostate cancer patients with early clinical failure and the impact of let-7 as prognostic marker in high-risk prostate cancer.23798998
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur findings define a distinct miRNA expression profile in PCa cases with early CF and identified let-7b as prognostic biomarker in high-risk PCa.23798998
CHOANAL ATRESIA, POSTERIOR, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs, being important regulators of gene expression, are promising biomarkers in various cancer entities, though the impact as prognostic predictors in PCa is poorly understood.23798998
Ki-1+ Anaplastic Large Cell LymphomaEpigenetic AlterationsWe identified an miRNA signature of 7 miRNAs (5 upregulated: miR-512-3p, miR-886-5p, miR-886-3p, miR-708, miR-135b; 2 downregulated: miR-146a, miR-155) significantly associated with ALK(+) ALCL cases.23801630
Ki-1+ Anaplastic Large Cell Lymphoma, Peripheral T-Cell LymphomaEpigenetic AlterationsIn addition, we derived an 11-miRNA signature (4 upregulated: miR-210, miR-197, miR-191, miR-512-3p; 7 downregulated: miR-451, miR-146a, miR-22, miR-455-3p, miR-455-5p, miR-143, miR-494) that differentiates ALK(-) ALCL from other PTCLs.23801630
Stomach CarcinomaEpigenetic AlterationsUpregulation of microRNA 181c expression in gastric cancer tissues and plasma.23803080
NeoplasmsEpigenetic AlterationsThus, it is very important to perform microarray-based miRNA screening of tumors at different sites.23803104
Triple-Negative Breast Cancer Finding, NeoplasmsEpigenetic AlterationsSeventeen kinds of miRNAs were heterogeneously distributed in the tumors from different clinicopathological subtypes that included 1 kind of miRNA in Luminal A and Luminal B Her2+ subtypes, 4 kinds in Luminal A and Her2 overexpression subtypes, 6 kinds in Luminal B Ki67+ and Luminal B Her2+ subtypes, 2 kinds between Luminal B Ki67+ and triple-negative breast cancer (TNBC) subtypes, 2 kinds between Luminal B Her2+ and TNBC subtypes, and 2 kinds between Luminal B Ki67+, Luminal B Her2+, and TNBC subtypes.23803104
Breast CarcinomaEpigenetic AlterationsDifferential distribution of microRNAs in breast cancer grouped by clinicopathological subtypes.23803104
Metastasis, NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs) that regulate proliferation, invasion and metastasis are considered to be the principal molecular basis of tumor heterogeneity.23803104
NeoplasmsEpigenetic AlterationsAll differential miRNAs were analyzed between the edges and centers of the tumors.23803104
NeoplasmsEpigenetic AlterationsTwenty kinds of miRNAs were homogenously distributed in the tumors from different clinicopathological subtypes that included 6 kinds of miRNAs in Luminal B Ki67+ and Luminal B Her2+ subtypes, 1 kind in Luminal B Ki67+ and Her2 overexpression subtypes, 10 kinds between Luminal B Ki67+ and TNBC subtypes, 2 kinds in Luminal B Her2+ and TNBC subtypes, and 1 kind between Luminal B Ki67+, Luminal B Her2+, and TNBC subtypes.23803104
NeoplasmsEpigenetic AlterationsA total of 37 miRNAs were significantly distributed in tumors from the centers to edges, and in all clinicopathological subtypes.23803104
B-Cell LymphomasEpigenetic AlterationsFinally, treatment with methyl inhibitors induced re-expression of ANGPT2 in two B-cell lymphoma cell lines, underscoring the importance of DNA methylation in regulating transcriptional silencing of this gene.23803577
Chronic Lymphocytic LeukemiaEpigenetic AlterationsIn conclusion, we believe that the known variability in ANGPT2 expression among CLL patients could be explained by differential promoter DNA methylation and that low methylation levels of the ANGPT2 promoter have an adverse prognostic impact in CLL.23803577
Coronary Artery DiseaseEpigenetic AlterationsImpact of intravenous heparin on quantification of circulating microRNAs in patients with coronary artery disease.23803974
Liver CirrhosisEpigenetic AlterationsCirculating microRNAs as a Fingerprint for Liver Cirrhosis.23805240
Carcinoma of lung, cell transformation, NeoplasmsEpigenetic AlterationsTo date, aberrant DNA methylation has been shown to be one of the most common and early causes of malignant cell transformation and tumors of different localizations, including lung cancer.23806794
Stomach Carcinoma, MetastasisEpigenetic AlterationsValidation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer.23806809
MetastasisEpigenetic AlterationsThen, we compared the level of three miRNAs (miR-21, miR-146a, and miR-148a) with the total of 79 GC patients with or without LN metastasis.23806809
Hepatocellular Carcinoma pN0 TNM Finding v8Epigenetic AlterationsLevels of the miRNAs were significantly different between pN0 and pN0 in the pT1 group (P = 0.013, P = 0.004, and P = 0.035, respectively) and among clinical stages (P = 0.001, P = 0.002, and P < 0.001, respectively).23806809
Liver carcinomaEpigenetic AlterationsSerum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma.23810247
Liver carcinomaEpigenetic AlterationsClinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma.23812667
Liver carcinomaEpigenetic AlterationsA 30-miRNA signature consisting of 10 downregulated and 20 upregulated miRNAs was established for distinguishing hepatocellular carcinoma from noncancerous liver tissues in the training set with 99.2% accuracy.23812667
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in the development and progression of cancer.23812667
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-203 down-regulation is associated with unfavorable prognosis in human glioma.23813496
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-203 (miR-203) serves as a tumor suppressor or a tumor promoter in different human malignancies.23813496
Chronic Obstructive Airway DiseaseEpigenetic AlterationsIncreased skeletal muscle-specific microRNA in the blood of patients with COPD.23814167
Structure of quadriceps femoris muscle, Chronic Obstructive Airway Disease, Skeletal muscle weaknessEpigenetic AlterationsReduced expression of muscle-specific microRNA (myomiRs) in quadriceps muscle in patients with COPD is associated with skeletal muscle weakness and changes in muscle fibre composition.23814167
Chronic Obstructive Airway DiseaseEpigenetic AlterationsMuscle-specific miRNA was elevated in the plasma of patients with COPD and showed distinct patterns.23814167
Acute lymphocytic leukemia, Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNA-223 mimics was transfected to increase the expression of MicroRNA-223 in the lymphocytes sorted by ficoll separation from the bone marrow mononuclear cells (BMMNC) of ALL and CLL patients.23815897
Acute lymphocytic leukemia, Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe results indicated that before the transfection, the expression of MicroRNA-223 in ALL and CLL cells was (433.11 +- 144.88), which was significantly lower than that in the normal lymphocyte (949.59 +- 267.39); the expression of LMO2 was (807.10 +- 238.41), which was significantly higher than that in the normal lymphocytes (455.32 +- 176.83) (P < 0.05); after the transfection, the expression of MicroRNA-223 was (571.86 +- 142.00) in ALL and CLL cells, which was significantly higher than that before transfection (P < 0.05), but the expression of LMO2 was significantly lower than that before transfection (651.97 +- 230.12) (P < 0.05); in the normal control the expression of MicroRNA-223 obviously decreased (646.32 +- 172.93) (P < 0.05), the expression of LMO2 was significantly increased (541.27 +- 158.86.2) (P < 0.05).23815897
Lymphoid leukemia, Abnormal lymphocyte apoptosisEpigenetic AlterationsIt is concluded that the expression of MicroRNA-223 decreases, and the expression of LMO2 increases in lymphocytic leukemia cells which leads to the lymphocytes over-proliferation and abnormal apoptosis, thus may be one of pathogenesis in lymphocytic leukemia.23815897
Malignant NeoplasmsEpigenetic AlterationsAltered microRNA (miRNA) expression has been found in many cancers, including lung, breast, prostate, bladder and colorectal cancer.23817697
Laryngeal Squamous Cell CarcinomaEpigenetic AlterationsHowever, the alteration in plasma miRNA expressions in laryngeal squamous cell carcinoma (LSCC) remains unclear.23817697
Laryngeal Squamous Cell CarcinomaEpigenetic AlterationsDifferential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma.23817697
Malignant NeoplasmsEpigenetic AlterationsMany recent studies have demonstrated that aberrant plasma miRNAs were also found in various types of cancers.23817697
Injury of central nervous systemEpigenetic AlterationsDifferential miRNA expression may therefore provide insight into mechanisms responsible for distinct phenotypic and functional properties of myeloid cells, thus impacting their ability to influence CNS injury and repair.23818336
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are small, noncoding RNAs that are critical regulators of various diseases, including cancer, which may represent a novel class of cancer biomarkers.23819812
cervical cancerEpigenetic AlterationsWe hypothesized that microRNA-20a (miR-20a) and microRNA-203 (miR-203), which were altered in lymphatic metastatic tissues, could be directly assayed in the serum and used to detect the lymph node status of cervical cancer patients.23819812
cervical cancer, MetastasisEpigenetic AlterationsCirculating miRNA-20a and miRNA-203 for screening lymph node metastasis in early stage cervical cancer.23819812
Breast CarcinomaEpigenetic AlterationsWe have developed a user-friendly, web-based system to allow the evaluation of genes/microRNAs (miRNAs) that are significantly associated with survival in breast cancer and its molecular subtypes.23820017
Malignant Neoplasms, Primary malignant neoplasm, Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) play a key role in cancer pathogenesis and are involved in several human cancers, including non-small cell lung cancer (NSCLC).23820752
Squamous cell carcinoma, Adenocarcinoma, Non-Small Cell Lung CarcinomaEpigenetic AlterationsNo significant association was observed between the analysed miRNAs and the main clinicopathological or molecular characteristics of the NSCLC patients, although both miRNAs were downregulated in squamous cell carcinomas compared to adenocarcinomas.23820752
Aggressive behavior, Ocular Adnexal LymphomaEpigenetic AlterationsMicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease.23821202
Diffuse Large B-Cell LymphomaEpigenetic AlterationsWe conclude that fundamental differences in miRNA expression exist between ocular adnexal EMZL and DLBCL, mainly due to differences in MYC and NF-kB regulatory pathways.23821202
Diffuse Large B-Cell LymphomaEpigenetic AlterationsSeven of the miRNAs down-regulated in DLBCL relative to EMZL showed enrichment for a direct transcriptional repression by the oncoprotein MYC.23821202
Chronic Lymphocytic LeukemiaEpigenetic AlterationsNoncoding RNAs play a pivotal role in the pathogenesis of chronic lymphocytic leukemia (CLL).23821659
Lymphocyte count increased, Chronic Lymphocytic LeukemiaEpigenetic AlterationsWe hypothesized that microRNAs (miRs) are involved in the transition from monoclonal B-cell lymphocytosis (MBL) to CLL and tested miR-15a/16-1 cluster, miR-21, and miR-155 expression in purified B cells of normal individuals, individuals with MBL, and patients with CLL.23821659
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsMicroRNA (miRNA) may be potential biomarkers of Alzheimers disease (AD).23822153
Admitting diagnosisEpigenetic AlterationsIn conclusion, miRNA present in human biofluids may offer utility as biomarkers of AD.23822153
Plaque (lesion)Epigenetic AlterationsThe objective of this investigation was to demonstrate that miRNAs in human brain or biofluids are differentially expressed according to disease status, tissue type, neuritic plaque score or Braak stage.23822153
Ovarian Serous AdenocarcinomaEpigenetic AlterationsHigh-grade serous ovarian carcinoma (HG-SOC) is a heterogeneous, poorly classified, lethal disease that frequently exhibits altered expressions of microRNAs.23825028
Muscle, Smooth, VascularEpigenetic AlterationsWe previously showed that constitutive Smad2 activation is associated with Smad2 mRNA overexpression in aneurysmal vascular smooth muscle cells (VSMCs), which is dependent on epigenetic regulation of the SMAD2 promoter involving histone modifications.23825360
NCI CTEP SDC Oligodendroglial Tumors Sub-Category TerminologyEpigenetic AlterationsGenetic and epigenetic alterations in primary-progressive paired oligodendroglial tumors.23826216
Primary NeoplasmEpigenetic AlterationsEpigenetic analysis detected promoter methylation of the MGMT, P16, DAPK, PTEN, RASSF1A, and Rb1 genes in 38.1%, 19.0%, 38.1%, 33.3%, 66.7%, and 14.3% of primary tumors, respectively.23826216
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDown-regulation of microRNA-181b is a potential prognostic marker of non-small cell lung cancer.23827213
S100A4 protein, humanEpigenetic AlterationsFurther investigation and validation of our microRNA database of MPM may elucidate previously unrecognized molecular pathways and/or mechanisms by identifying novel microRNAs that are involved in malignant transformation.23828229
NeoplasmsEpigenetic AlterationsIn addition to several novel MPM-associated microRNAs, we observed that the expression level of miR-1 was significantly lower in tumors as compared with normal pleural specimens.23828229
Gastric AdenocarcinomaEpigenetic AlterationsWe studied the comprehensive DNA methylation status in the naturally derived gastric adenocarcinoma cell line SNU-719, which was infected with the Epstein-Barr virus (EBV) by methylated CpG island recovery on chip assay.23829175
Primary malignant neoplasmEpigenetic AlterationsWe verified DNA methylation of the genes in 75 primary gastric cancer tissues from 25 patients with EBVaGC and 50 EBV-negative patients who were controls.23829175
B-Cell LymphomasEpigenetic AlterationsGenome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma.23831920
NeoplasmsEpigenetic AlterationsTo identify a unique microRNA (miRNA) pattern associated with the progression of OSC at early and advanced stages, a miRNA microarray was performed using Chinese tumor bank specimens of patients with OSC stage I or III in a retrospective analysis.23836287
Ovarian Serous AdenocarcinomaEpigenetic AlterationsMiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma.23836287
Carcinoma of lungEpigenetic AlterationsFor TIMP3, males showed lower methylation frequency than females (OR=0.18, 95%CI=0.04-0.88) while central lung cancer, heavy smoking and radiation exposure presented higher aberrant DNA methylation status (OR=2.19, 95%CI=1.07-4.52; OR=6.99, 95%CI=1.32-37.14; OR=2.30, 95%CI=1.04-5.08).23838140
Primary malignant neoplasmEpigenetic AlterationsThere is increasing evidence that microRNA expression in cancer tissue is useful for predicting the prognosis of patients with cancer.23838916
Esophageal carcinomaEpigenetic AlterationsHowever, the relationship between the levels of circulating microRNAs and response to chemotherapy and prognosis remains unclear in esophageal cancer.23838916
NeoplasmsEpigenetic AlterationsTissue sections from the deepest invasive tumour front were processed for miRNA-126 ISH and CD34 immunohistochemistry (IHC).23838926
Colorectal Cancer PathwayEpigenetic AlterationsThe functional significance of microRNA-29c in patients with colorectal cancer: a potential circulating biomarker for predicting early relapse.23840538
Clinical CoordinatorEpigenetic AlterationsWe recently identified microRNA-29c (miRNA-29c) as a predictor of early recurrence in CRC.23840538
Clinical CoordinatorEpigenetic AlterationsmiRNA-29c expression significantly decreased during early relapse compared to non-early relapse in UICC stage II and III CRC patients (P = 0.021).23840538
NeoplasmsEpigenetic AlterationsIn vivo, miRNA-29c suppressed tumor growth in null mice.23840538
Clinical CoordinatorEpigenetic AlterationsmiRNA-29c shows anti-tumorigenesis activity, and preoperative circulating miRNA-29c levels can be used to predict postoperative early relapse of CRC.23840538
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsmicroRNAs have been suggested to play roles in carcinogenesis and cancer recurrence.23840538
Diffuse Large B-Cell LymphomaEpigenetic AlterationsWe compared miRNA expression profiles in lymph node tissues of patients with DLBCL of the activated B-cell like (ABC) type from two geographical areas with different background exposures, Sweden and Egypt.23841503
Malignant neoplasm of urinary bladderEpigenetic AlterationsDNA methylation is associated with bladder cancer and these modifications could serve as useful biomarkers.23842048
Liver carcinoma, NeoplasmsEpigenetic AlterationsDownregulation of microRNA-100 correlates with tumor progression and poor prognosis in hepatocellular carcinoma.23842624
S100A4 protein, human, NeoplasmsEpigenetic AlterationsIncreasing evidence suggests that dysregulation of microRNAs is correlated with malignant transformation and tumor development.23842624
Malignant Neoplasms, Retinitis PigmentosaEpigenetic AlterationsRecurrence-associated miRNAs were subsequently quantitated by qRT-PCR in a validation cohort comprised of 70 patients with Gleason 7 cancers treated by RP, 31 of whom had undergone disease progression following surgery.23846169
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsmicroRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2.23846336
Primary malignant neoplasmEpigenetic AlterationsOver-expression of long non-coding RNA HOTAIR has been reported in several types of cancer.23847441
Central visual impairmentEpigenetic AlterationsTaken together, our data suggest that common genetic variations in COL1A2 may influence CVI risk, possibly through microRNA-382-mediated regulation.23849651
DICER1 protein, humanEpigenetic AlterationsDicer is an RNase III enzyme essential for the maturation of the majority of microRNAs.23851498
Prostate Cancer Pathway, DICER1 protein, human, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsComplete ablation of Dicer activity in a Pten null mouse model for prostate cancer significantly halts tumor growth and progression, demonstrating that microRNAs have a critical role in maintaining cancer cell fitness.23851498
Breast CarcinomaEpigenetic AlterationsEstrogen receptor a regulates ATM Expression through miRNAs in breast cancer.23857602
Cerebrovascular DisordersEpigenetic AlterationsSerum microRNA-21 and microRNA-221 as potential biomarkers for cerebrovascular disease.23860376
Cerebrovascular accidentEpigenetic AlterationsTo test the prediction for stroke, we built regression models containing the serum miRNA levels and risk factors.23860376
cervical cancerEpigenetic AlterationsMicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer.23861821
Liver carcinomaEpigenetic AlterationsMicroRNA-34a targets Bcl-2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment.23862748
Hepatitis B, Liver carcinomaEpigenetic AlterationsMicrovesicle microRNA profiles and functional roles between chronic hepatitis B and hepatocellular carcinoma.23864279
Hollings Cancer Center, Complete atrioventricular blockEpigenetic AlterationsWe demonstrated that CHB and HCC displayed aberrantly co-expressed MV miRNA profiles for the first time, which may have a link between CHB and HCC.23864279
Hollings Cancer Center, Complete atrioventricular blockEpigenetic AlterationsAmong them, 25 co-expressed MV miRNAs targeted 21 inflammatory factors and these miRNAs may be a tight linkage between CHB and HCC.23864279
Hollings Cancer Center, Complete atrioventricular blockEpigenetic AlterationsThose MV miRNAs may play roles in CHB developing to HCC.23864279
Hollings Cancer Center, Complete atrioventricular blockEpigenetic AlterationsThose MV miRNAs may serve as early biomarkers for HCC and may aid to promote CHB developing to HCC.23864279
AdenomaEpigenetic AlterationsDistinct patterns of DNA methylation in conventional adenomas involving the right and left colon.23868178
Colorectal Cancer Pathway, AdenocarcinomaEpigenetic AlterationsRecent studies have shown two distinct non-CIMP methylation clusters in colorectal cancer, raising the possibility that DNA methylation, involving non-CIMP genes, may play a role in the conventional adenoma-carcinoma pathway.23868178
AdenomaEpigenetic AlterationsA total of 135 adenomas (65 left colon and 70 right colon) were profiled for epigenome-wide DNA methylation using the Illumina HumanMethylation450 BeadChip.23868178
AdenomaEpigenetic AlterationsLinear regression and linear mixed effects models were used to identify locus-specific differential DNA methylation in adenomas of right and left colon.23868178
AdenomaEpigenetic AlterationsIn summary, our results indicate distinct patterns of DNA methylation, independent of CIMP genes, in adenomas of the right and left colon.23868178
PterygiumEpigenetic AlterationsmiRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.23872359
PterygiumEpigenetic AlterationsGenome-wide miRNA and mRNA expression profiling of paired pterygium and normal conjunctiva was performed in the context of conventional excision of pterygium with autotransplantation of conjunctiva (n = 8).23872359
PterygiumEpigenetic AlterationsIn pterygium, 25 miRNAs and 31 mRNAs were significantly differentially expressed by more than two-fold compared to normal conjunctiva.23872359
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsNTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer.23874207
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsIn summary, our findings suggest NTRK3 is a conditional tumor suppressor gene that is commonly inactivated in colorectal cancer by both epigenetic and genetic mechanisms whose function in the pathogenesis of colorectal cancer depends on the expression status of its ligand, NT-3.23874207
Metastasis, NeoplasmsEpigenetic AlterationsHigh-throughput miRNA and mRNA sequencing of paired colorectal normal, tumor and metastasis tissues and bioinformatic modeling of miRNA-1 therapeutic applications.23874421
Colorectal Cancer Pathway, Metastasis, NeoplasmsEpigenetic AlterationsTo identify potential miRNA drugs in colorectal cancer, we profiled miRNA and mRNA expression in matching normal, tumor and metastasis tissues of eight patients by Illumina sequencing.23874421
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsWe validated six miRNAs in a large tissue screen containing 16 additional tumor entities and identified miRNA-1, miRNA-129, miRNA-497 and miRNA-215 as constantly de-regulated within the majority of cancers.23874421
Mammary NeoplasmsEpigenetic AlterationsThis data presents miR-379 as a novel regulator of Cyclin B1 expression, with significant loss of the miRNA observed in breast tumours.23874748
HepatocarcinogenesisEpigenetic AlterationsEpigenetic alterations are well documented in hepatocarcinogenesis.23875825
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsIdentification of microRNAs in blood and urine as tumour markers for the detection of urinary bladder cancer.23877086
Bladder NeoplasmEpigenetic AlterationsThree blood miRNAs (miR-26b-5p, miR-144-5p, miR-374-5p) were found to be significantly upregulated in invasive bladder tumour patients (P<0.05) when compared to the control group.23877086
NeoplasmsEpigenetic AlterationsThe expression of 2 miRNAs (miR-618, miR-1255b-5p) in the urine of patients with invasive tumours was significantly (P<0.05) increased in comparison to the control group.23877086
Benign neoplasm of bladderEpigenetic AlterationsIn addition, it was shown that invasive bladder tumours could be identified by differentially expressed urine miRNAs.23877086
diabetic, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsAlthough a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by differential DNA methylation of GLP1R in pancreatic islets of type 2 diabetic patients.23879380
NeoplasmsEpigenetic AlterationsCurrently, the methylation epigenetic silencing of miRNAs with tumor suppressor features by CpG island hypermethylation is emerging as a common hallmark of different tumors.23880861
Malignant NeoplasmsEpigenetic AlterationsThe discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanism, diagnosis and treatment of human cancers.23880861
Malignant neoplasm of kidneyEpigenetic AlterationsDNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome.23881922
Primary malignant neoplasmEpigenetic AlterationsData of an independent ccRCC cohort from The Cancer Genome Atlas (TCGA) were analyzed on MCT4 mRNA (n = 482) and DNA methylation (n = 283) level.23881922
Imprinting (Psychology)Epigenetic AlterationsHowever, early investigations suggested that children born as a result of ART had higher risk of diseases with epigenetic etiologies, including imprinting disorders caused by a lack of maternal methylation at imprinting control elements.23884645
Chronic diseaseEpigenetic AlterationsThe level of these miRNAs may serve as new potential biomarkers for this chronic disease.23885139
Primary malignant neoplasmEpigenetic AlterationsWhen present in PRC2, EZH2 catalyzes trimethylation on lysine 27 residue of histone H3, resulting in epigenetic silencing of gene expression and cancer progression.23887863
High-Resolution MicroendoscopyEpigenetic AlterationsHRM is as a simple, cost-effective method for the reliable high-throughput quantification of DNA methylation in clinical material.23888343
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThe aberrant promoter methylation of tumor suppressor genes is a typical epigenetic alteration for breast cancer and can be detected in early carcinogenesis.23888343
Breast CarcinomaEpigenetic AlterationsThe main purpose of our study was to optimize a high-resolution melting (HRM) assay for the reliable and quantitative assessment of RASSF1 gene methylation, which is considered one of the earliest epigenetic alterations in breast cancer.23888343
CarcinogenesisEpigenetic AlterationsHowever, the effects of ROS on miRNAs expression and the role of miRNAs in ROS-mediated injury on carcinogenesis are uncertain.23888942
Malignant NeoplasmsEpigenetic AlterationsAberrant DNA methylation is a recognized feature of human cancers and folate is directly involved in DNA methylation via one-carbon metabolism.23888945
Malignant NeoplasmsEpigenetic AlterationsFolate supplement and recovery of aberrant DNA methylation status may offer a new strategy for prevention and therapy of cancers.23888945
Renal Cell Carcinoma PathwayEpigenetic AlterationsTumor-suppressive microRNA-1291 directly regulates glucose transporter 1 in renal cell carcinoma.23889809
NeoplasmsEpigenetic AlterationsDifferences in microRNA expression during tumor development in the transition and peripheral zones of the prostate.23890084
NeoplasmsEpigenetic AlterationsMicroRNA signatures that are specific for PZ and TZ tumors could also lead to more accurate prognoses, since tumors arising in the PZ tend to be more aggressive than tumors arising in the TZ.23890084
NeoplasmsEpigenetic AlterationsThe results also indicate that separate miRNA expression signatures for diagnosis might be needed for tumors arising in the different zones.23890084
NeoplasmsEpigenetic AlterationsIn addition, tumors arising in the TZ have more unique differentially expressed miRNAs compared to the PZ.23890084
SclerodermaEpigenetic AlterationsDetection of hair-microRNAs as the novel potent biomarker: evaluation of the usefulness for the diagnosis of scleroderma.23890704
Malignant Neoplasms, Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsHepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and is caused by the accumulation of genetic and epigenetic alterations in regulatory genes.23891693
Bone necrosisEpigenetic AlterationsEffects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw.23892139
Bone lesionEpigenetic AlterationsDifferences in DNA methylation induced by BP treatment could be involved in the pathogenesis of the bone lesion.23892139
Adenocarcinoma of lung (disorder)Epigenetic AlterationsClinic significance of microRNA-99a expression in human lung adenocarcinoma.23893385
Zebrafish, Sample Size CalculationEpigenetic AlterationsAlteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor b.23893664
Sample Size CalculationEpigenetic AlterationsAlthough several miRNAs have been shown to regulate autoimmune pathogenesis by affecting lymphocyte function, the roles of miRNAs in the pathogenesis of SSc remain unclear.23893664
Sample Size CalculationEpigenetic AlterationsThe expression of these miRNAs in sera of SSc patients and healthy controls was measured by quantitative PCR.23893664
Sample Size CalculationEpigenetic AlterationsNineteen of 95 miRNAs were significantly decreased in the sera of SSc patients.23893664
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsUnique DNA methylation loci distinguish anatomic site and HPV status in head and neck squamous cell carcinoma.23894057
nervous system disorder, Admitting diagnosisEpigenetic AlterationsThe data indicate that deregulated miRNAs in blood might be used as biomarkers in the diagnosis of AD or other neurological diseases.23895045
Leukemia, Myelocytic, AcuteEpigenetic AlterationsOverexpression of primary microRNA 221/222 in acute myeloid leukemia.23895238
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe expression of 636 human miRNAs was compared between samples from 52 patients with AML and 13 healthy individuals by highly specific locked nucleic acid (LNA) based microarray technology.23895238
Leukemia, Myelocytic, AcuteEpigenetic Alterations64 miRNAs were significantly differentially expressed between AML and controls.23895238
Leukemia, Myelocytic, AcuteEpigenetic AlterationsExpression of some miRNAs is strongly regulated at the posttranscriptional level in AML.23895238
Nasopharyngeal carcinomaEpigenetic AlterationsDeficiency in expression and epigenetic DNA Methylation of ASS1 gene in nasopharyngeal carcinoma: negative prognostic impact and therapeutic relevance.23897555
Aggressive behavior, NeoplasmsEpigenetic AlterationsAttributable to epigenetic DNA methylation, ASS1 deficiency may link to the therapeutic sensitivity to the arginine-depriving agents and promote tumor aggressiveness through its newly identified tumor suppressor function.23897555
Aggressive behavior, NeoplasmsEpigenetic AlterationsIn summary, ASS1 protein deficiency was seen in approximately a half of NPCs and associated with advanced T classification, DNA methylation, and clinical aggressiveness, consistent with its tumor suppressor role.23897555
Carcinoma, Transitional Cell, Ulcerative ColitisEpigenetic AlterationsVariations in urothelial carcinoma (UC) response to platinum chemotherapy are common and frequently attributed to genetic and epigenetic variations of somatic DNA.23897706
Rheumatoid Arthritis, Right armEpigenetic AlterationsmiRNAs have features of potential biomarkers, and an altered expression of miRNAs was shown in established rheumatoid arthritis (RA).23897768
Right armEpigenetic AlterationsTo analyse RA associated miRNAs in the sera of patients with ERA to find markers of early disease, clinical activity or predictors of disease outcome.23897768
Right armEpigenetic AlterationsFrom all analysed miRNAs, levels of miR-146a, miR-155 and miR-16 were decreased in the sera of ERA patients in comparison with established RA.23897768
Gastric AdenocarcinomaEpigenetic AlterationsEvaluation of MicroRNA expression pattern of gastric adenocarcinoma associated with socioeconomic, environmental and lifestyle factors in northwestern Hungary.23898078
Primary malignant neoplasmEpigenetic AlterationsSince microRNAs (miRNAs) represent an emerging field of cancer research, there is an increasing interest regarding the miRNA responses to environmental and lifestyle exposures.23898078
Gastric AdenocarcinomaEpigenetic AlterationsDifferential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic regions population show homogenous correlations with the existence of common risk factors.23898078
Primary malignant neoplasmEpigenetic AlterationsAccumulating evidence has identified that polymorphism residing in the microRNA (miRNA) binding site of target genes can affect the strength of miRNA binding and influence individual susceptibility to cancer.23900673
NeoplasmsEpigenetic AlterationsThese tumors overexpress HIF-1a protein and target genes and the HIF-inducible microRNA miR-210 (pHx-HNPGLs).23902947
NeoplasmsEpigenetic AlterationsIn miRNAs that were downregulated in the tumors, Let-7f-2 and miR-22 differed the most (P < 0.001 and P = 0.007, respectively).23904007
NeoplasmsEpigenetic AlterationsWe postulate that mRNA-protein decoupling of BCAR1 may be a result of reduced inhibition of specific miRNAs in tumor tissues, which warrants further study.23904007
Breast CarcinomaEpigenetic AlterationsEvaluation of protein expression and DNA methylation profiles detected by pyrosequencing in invasive breast cancer.23906298
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsBy using pyrosequencing, we analysed DNA methylation levels of 11 genes, namely APC, ADAM23, CXCL12, ESR1, PGR B, CDH1, RASSF1A, SYK, TIMP3, BRMS1 and SOCS1 in tumour, plasma and peripheral blood cells from 34 patients with primary breast cancer, as well as plasma and peripheral blood cells from 50 healthy controls.23906298
NeoplasmsEpigenetic AlterationsOn the other hand, no correlations were observed in patients between DNA methylation in tumours and cell-free plasma DNA.23906298
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsThe DNA methylation profiles manifested in our group of breast carcinomas are cancer specific, but they are not the only cause that affects the silencing of evaluated genes and the decrease of relevant protein products.23906298
palladiumEpigenetic AlterationsImportantly, we identified concordant methylation alterations in brain and blood, suggesting that blood might hold promise as a surrogate for brain tissue to detect DNA methylation in PD and as a source for biomarker discovery.23907097
ovarian neoplasm, NeoplasmsEpigenetic AlterationsUpregulation of microRNA-203 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer.23918241
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNA-203 (miR-203), possessing tumor suppressive or promotive activities, has been found to be downregulated or upregulated in different cancer types.23918241
Prostate Cancer PathwayEpigenetic AlterationsDNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer.23918943
NeoplasmsEpigenetic AlterationsCirculating profiles of miRNAs have been shown to discriminate different tumor types, indicate staging and progression of the disease and to be useful as prognostic markers.23922807
Glioblastoma MultiformeEpigenetic AlterationsRelationship between magnetic resonance imaging features and miRNA gene expression in patients with glioblastoma multiforme.23924460
NeoplasmsEpigenetic AlterationsRecent research has shown that microRNAs (miRNAs) may act as oncogenes, or in some cases, tumor suppressor genes that in turn may reflect the genotypic features of GBM.23924460
NeoplasmsEpigenetic AlterationsThe miRNAs such as hsa-miR-95, hsa-miR-498, and hsa-miR-1300 were associated with a contrast tumor enhanced/T2 ratio >=1.23924460
MIR524 gene, Hemorrhage, MIR612 geneEpigenetic AlterationsThe miRNAs such as hsa-miR-612, hsa-miR-524-3, and hsamiR-1282 were associated with multiple lesions identified on MRI and the expression of miR-221 was associated with hemorrhage by GBM.23924460
NecrosisEpigenetic AlterationsThe gene expression of miRNAs such as hsa-miR-140-5p, hsa-miR-30e, and hsa-miR-301a was relatively low when compared with the larger necrotic volume group as identified by MRI.23924460
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations are a hallmark of cancer that govern the silencing of genes.23924947
Barrett EsophagusEpigenetic AlterationsMicroRNA expression differentiates squamous epithelium from Barretts esophagus and esophageal cancer.23925817
BiliaryEpigenetic AlterationsMicroRNA profiles in graft preservation solution are predictive of ischemic-type biliary lesions after liver transplantation.23928409
Biliary strictureEpigenetic AlterationsMicroRNA profiles in perfusates from grafts that developed ITBL (n=20) and grafts without biliary strictures (n=37) were compared.23928409
IschemiaEpigenetic AlterationsGraft preservation solutions (perfusates) and paired liver biopsies collected at the end of cold ischemia were analysed by RT-qPCR for CDmiR-30e, CDmiR-222, and CDmiR-296 and hepatocyte-derived miRNAs (HDmiRs) HDmiR-122 and HDmiR-148a.23928409
Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsDNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.23931760
Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsLiver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling.23931760
Endoribonuclease ZC3H12AEpigenetic AlterationsOur findings provide an example of treatment-induced epigenetic organ remodeling in humans.23931760
Pancreatic carcinomaEpigenetic AlterationsEvidence suggests that deregulated miRNA expression is associated with pancreatic cancer development.23933230
Pancreatic Ductal Adenocarcinoma, Pancreatic intraepithelial neoplasiaEpigenetic AlterationsMicroRNAs as diagnostic markers for pancreatic ductal adenocarcinoma and its precursor, pancreatic intraepithelial neoplasm.23933230
Colorectal Cancer PathwayEpigenetic AlterationsClinical significance of microRNA-148a in patients with early relapse of stage II stage and III colorectal cancer after curative resection.23933284
Clinical CoordinatorEpigenetic AlterationsWe used microRNA arrays and identified that microRNA-148a (miRNA-148a) had substantially different expression levels in early and nonearly relapsed stage II and III CRC tissues.23933284
Clinical CoordinatorEpigenetic AlterationsSubsequently, we explored whether the serum level of miRNA-148a can be used to predict early CRC recurrence.23933284
Clinical CoordinatorEpigenetic AlterationsThis study showed that miRNA-148a can inhibit tumorigenesis and reduce the early recurrence of CRC.23933284
Clinical CoordinatorEpigenetic AlterationsThese findings suggest that miRNA-148a may have potential clinical applications for predicting the early relapse of patients with CRC after radical resection.23933284
Clinical CoordinatorEpigenetic AlterationsWe aimed to determine whether expression status of microRNAs might be a simple and reliable biomarker to detect postoperative early relapse in patients with CRC after radical resection.23933284
Esophageal carcinomaEpigenetic AlterationsBile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis.23933602
Astrocytoma, Glioblastoma Multiforme PathwayEpigenetic AlterationsGenomic and epigenetic data on astrocytoma have demonstrated that the IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.23934769
Primary malignant neoplasmEpigenetic AlterationsEmerging studies have indicated that microRNAs are involved in the development and progression of cancer.23936094
Parkinson DiseaseEpigenetic AlterationsLINE-1 DNA methylation, smoking and risk of Parkinsons disease.23938260
Parkinson DiseaseEpigenetic AlterationsPlasma-based circulating MicroRNA biomarkers for Parkinsons disease.23938262
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are small non-coding RNAs capable of inhibiting gene expression post-transcriptionally and expression profiling can provide therapeutic targets and tools for cancer diagnosis.23940002
ChondrosarcomaEpigenetic AlterationsWe further validated the expression levels of miRNAs by quantitative real-time PCR for miR-181a, let-7a, 100, 222, 136, 376a, and 335 in extended number of chondrosarcoma clinical samples.23940002
Hollings Cancer CenterEpigenetic AlterationsOur results suggested that the gene loss and epigenetic silencing of SOCS1 were strongly associated with HBV-related HCC.23941364
Gastric mucosa, CarcinogenesisEpigenetic AlterationsAberrant DNA methylation in noncancerous gastric mucosa is strongly implicated in gastric carcinogenesis and could be a useful biomarker of GC risk.23942619
Squamous cell carcinoma of esophagusEpigenetic AlterationsTherefore, H19 CBS6 methylation potentially represents a novel clinically relevant epigenetic marker to identify individuals at increased risk for the occurrence, progression and prognosis of ESCC.23943562
Stomach CarcinomaEpigenetic AlterationsExamination of whole blood DNA methylation as a potential risk marker for gastric cancer.23943784
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsVariability in whole blood DNA methylation of cancer markers is primarily associated with aging, reflecting turnover of white blood cells, and has no direct link to gastric cancer predisposition.23943784
Malignant neoplasm of urinary bladderEpigenetic AlterationsmiRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.23945108
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe verification of tumor-specific miRNA expression profile, together with the observed association of miR-141 and miR-205 expression with overall survival, underline the potential of miRNAs to function as diagnostic and/or prognostic markers of bladder cancer.23945108
Malignant neoplasm of urinary bladder, MIR20A geneEpigenetic AlterationsSeven miRNAs (miR-20a, miR-106b, miR-130b, miR-141, miR-200a, miR-200a*, and miR-205) were found to be up-regulated and eight miRNAs (miR-100, miR-125b, miR-130a, miR-139-5p, miR-145*, miR-199a-3p, miR-214, and miR-222) were found to be down-regulated in malignant bladder tissue samples compared to healthy tissue.23945108
Malignant neoplasm of urinary bladderEpigenetic AlterationsFour miRNAs that have already been described in the literature (miR-141, miR-199a-3p, miR-205, and miR-214) were significantly differentially expressed between nonmuscle-invasive and muscle-invasive bladder cancer.23945108
Malignant neoplasm of urinary bladderEpigenetic AlterationsFurthermore, real-time RT-qPCR of all miRNAs provided high overall correct classification (>75%) of bladder cancer diagnosis.23945108
Carcinoma of lungEpigenetic AlterationsmicroRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer.23945385
Granuloma, Adenocarcinoma of lung (disorder)Epigenetic AlterationsSix microRNAs (miR-151a-5p, miR-30a-3p, miR-200b-5p, miR-629, miR-100, and miR-154-3p) were selected for a second test on the nodule population to discriminate between lung adenocarcinoma and granuloma.23945385
Adenocarcinoma of lung (disorder)Epigenetic AlterationsMicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma.23946296
Adenocarcinoma of lung (disorder), Metastasis, Primary malignant neoplasmEpigenetic AlterationsWe conducted genome-wide miRNA-sequencing (miRNA-seq) in primary cancer tissue from patients of lung adenocarcinoma to identify markers for the presence of lymph node metastasis.23946296
Hypernatremia, Aortic Valve StenosisEpigenetic AlterationsMyocardial microRNA-133a (miR-133a) is directly related to reverse remodeling after pressure overload release in aortic stenosis patients.23948643
Colorectal Cancer PathwayEpigenetic AlterationsWe recently reported a fecal microRNA (miRNA) test (FmiRT) to detect colorectal cancer.23950216
Hollings Cancer CenterEpigenetic AlterationsWe have previously delineated the landscape of DNA methylation in HCC patients unraveling the importance of promoter hypomethylation in activation of cancer- and metastasis-driving genes.23950870
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAlthough the main thrust in DNA methylation diagnostics in cancer is on hypermethylated genes, our study for the first time illustrates the potential use of hypomethylated genes as markers for solid tumors.23950870
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAlthough aberrant DNA methylation patterning is a hallmark of cancer, the relevance of targeting DNA methyltransferases (DNMT) remains unclear for most tumors.23955273
Resistance Process, Diffuse Large B-Cell LymphomaEpigenetic AlterationsIn diffuse large B-cell lymphoma (DLBCL) we observed that chemoresistance is associated with aberrant DNA methylation programming.23955273
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have been integrated into cancer development and progression, because they repress translation of target genes which can be tumor suppressors and oncogenes.23959478
Non-Small Cell Lung CarcinomaEpigenetic AlterationsA number of miRNAs have been found to be closely related to human non-small cell lung cancer (NSCLC).23959478
Admitting diagnosisEpigenetic AlterationsIn conclusion, the abnormal expression of several miRNAs in hippocampus of intermediate- and late-stage AD patients suggests their involvement in AD pathogenesis, and low levels of miR-146a in CSF were associated with AD.23962497
NeoplasmsEpigenetic AlterationsThe microRNA miR-101 has been reported to be a tumor suppressor.23962556
Neoplasm MetastasisEpigenetic AlterationsWe also identified a subset of miRNAs associated with tumor metastasis and MCC-specific survival.23962809
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) play a crucial role in the pathogenesis of several malignancies via regulating gene expression.23963825
Malignant NeoplasmsEpigenetic AlterationsAberrant methylation in gene promoter is common in various cancers, and epigenetic alterations can result in down-regulation or silence of gene expression.23963856
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsA panel of 4 microRNAs facilitates the prediction of left ventricular contractility after acute myocardial infarction.23967079
Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA) is an emerging subclass of small non-coding RNAs that regulates gene expression and has a pivotal role for many physiological processes including cancer development.23967217
Malignant neoplasm of larynxEpigenetic AlterationsMicroRNA-196a is a putative diagnostic biomarker and therapeutic target for laryngeal cancer.23967217
estrogen receptor-positive breast cancer, NeoplasmsEpigenetic AlterationsWe performed a global microRNA screen (1105 human microRNAs) in primary tumours of six matched pairs of postmenopausal, ER-positive breast cancer patients treated with tamoxifen, who were either recurrence free or had developed a recurrence (median follow up: 8.84 years; range: 1.28-12.7 years).23968733
Breast CarcinomaEpigenetic AlterationsMicroRNAs have been suggested to be important prognosticators in breast cancer.23968733
Gastrointestinal Stromal TumorsEpigenetic AlterationsMicroRNAs that may have an essential role in GIST pathogenesis were identified, in particular miR-17/20a/222 that target KIT and ETV1.23969726
Gastrointestinal Stromal TumorsEpigenetic AlterationsDelivering these microRNAs therapeutically could hold great potential for GIST management, especially in imatinib-resistant disease.23969726
Carcinogenesis, NeoplasmsEpigenetic AlterationsAberrant DNA methylation has been recognized to contribute to breast carcinogenesis, and promoter hypermethylation of several tumor suppressor genes has been correlated with decreased gene expression.23969757
CarcinogenesisEpigenetic AlterationsEpigenetic parameters such as DNA methylation and histone modifications play pivotal roles in carcinogenesis.23969945
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsGlobal histone modification patterns have been implicated as possible predictors of cancer recurrence and prognoses in a great variety of tumor entities.23969945
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn conclusion, H3K27me3 level defines unrecognized subgroups of NSCLC patients with distinct epigenetic phenotype and clinical outcome, and can probably be used as a novel predictor for better prognosis in NSCLC patients.23969945
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) are small, noncoding RNAs that are involved in carcinogenesis through postranscriptional gene regulatory activity.23970420
Colorectal Cancer PathwayEpigenetic AlterationsPrognostic implications of serum microRNA-21 in colorectal cancer.23970420
Primary malignant neoplasmEpigenetic AlterationsGrowing evidence has indicated that polymorphism present in the miRNA binding site of target gene can alter the ability of miRNAs to bind its target gene and modulate the development and progression of cancer.23975373
Primary malignant neoplasmEpigenetic AlterationsAccumulating evidence suggests that aberrant expression of long non-coding RNAs (lncRNAs) play an important functional role in cancer biology.23976967
Fatty Liver Disease, Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsThe importance of genetics and epigenetic changes in the pathogenesis of non alcoholic fatty liver disease (NAFLD) has been increasingly recognized.23977033
Carcinoma of lungEpigenetic AlterationsOptimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients.23978937
Carcinoma of lung, NeoplasmsEpigenetic AlterationsThis method was applied to assess the optimal amounts of enzymes required for DNA digestion regarding an accurate global DNA methylation determination and completeness of digestion and to determine global methylation in human tumor adjacent lung tissue of 79 lung cancer patients.23978937
Squamous cell carcinoma, AdenocarcinomaEpigenetic AlterationsGlobal DNA methylation levels in adenocarcinoma and squamous cell carcinoma patients were similar in the range of 3.16-4.01 %.23978937
Carcinoma of lungEpigenetic AlterationsGlobal DNA methylation levels were not affected by smoking and gender and were not correlated with N7-meG or 8-oxodG in lung cancer patients.23978937
Malignant NeoplasmsEpigenetic AlterationsIncreasing evidence suggests that large-scale loss of 5-hmC is an epigenetic hallmark of several human cancers.23980508
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsAberrant DNA methylation of promoter region CpG islands may serve as an alternative mechanism to genetic defects in the inactivation of tumor suppressor genes (TSGs) in human malignancies.23980519
Primary malignant neoplasmEpigenetic AlterationsGrowing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression.23981575
Stomach CarcinomaEpigenetic AlterationsThe aim of this study was to characterize the epigenetic inactivation of Reprimo and its biologic function and clinical relevance in gastric cancer.23982217
CarcinomaEpigenetic AlterationsCarcinomas initiate and progress due to genetic and epigenetic alterations in epithelial cells.23982433
MetastasisEpigenetic AlterationsAfter initial screening, miR-200c was selected as the candidate serum miRNA best associated with metastasis.23982750
Clinical Coordinator, Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsTo evaluate the ability of epithelial-to-mesenchymal transition-related microRNAs (miRNAs) as serum biomarkers for prognosis and prediction of metastasis in patients with colorectal cancer (CRC).23982750
Clinical Coordinator, MetastasisEpigenetic AlterationsEpithelial-to-mesenchymal transition-related miRNAs drive CRC progression and metastasis.23982750
Clinical Coordinator, MetastasisEpigenetic AlterationsIn the first phase, we selected candidate miRNAs associated with metastasis by analyzing the expression of 4 miR-200 family members (miR-200b, -200c, -141, and -429) in serum samples from 12 patients with stage I and IV CRC.23982750
Clinical CoordinatorEpigenetic AlterationsThe second phase involved independent validation of candidate miRNAs in serum from 182 patients with CRC and 24 controls.23982750
Clinical Coordinator, Secondary malignant neoplasm of liver, NeoplasmsEpigenetic AlterationsFinally, we analyzed expression in matched 156 tumor tissues from 182 patients with CRC and an independent set of 20 matched primary CRC and corresponding liver metastases to identify the source of circulating miRNAs.23982750
Traumatic injuryEpigenetic AlterationsWe identified a miRNA profile involved in posttranscriptional regulatory mechanisms in I/R injury post-LT. A better understanding of these molecular processes involved in I/R may contribute to develop new strategies to minimize graft injury.23985720
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsTaken together, our data indicate that galectin-7 has a tumor suppressive function, and that the gene is epigenetically modified by DNA methylation and significantly down-regulated in gastric cancer.23985992
NeoplasmsEpigenetic AlterationsMost changes in miRNA and gene expression levels had already manifested in the primary tumors while these levels were almost stably maintained in the subsequent primary tumor-to-metastasis transition.23987127
Clinical Coordinator, NeoplasmsEpigenetic AlterationsUsing a large dataset of CRC miRNA and gene expression profiles, we describe the interplay of miRNA groups in regulating gene expression, which in turn affects modulated pathways that are important for tumor development.23987127
Carcinogenesis, MetastasisEpigenetic AlterationsImpact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis.23987127
Malignant tumor of colon, Primary NeoplasmEpigenetic AlterationsQualitative alterations or abnormal expression of microRNAs (miRNAs) in colon cancer have mainly been demonstrated in primary tumors.23987127
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsPoorly overlapping sets of oncomiRs, tumor suppressor miRNAs and metastamiRs have been linked with distinct stages in the progression of colorectal cancer.23987127
NeoplasmsEpigenetic AlterationsOf 82 miRNAs that were modulated during tumor progression, 22 were involved in EMT.23987127
Colorectal Cancer PathwayEpigenetic AlterationsAberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island.23988185
Primary malignant neoplasmEpigenetic AlterationsBecause the DNA methylation landscape of different regions of SEPT9 is poorly understood in cancer, we analyzed the methylation patterns of this gene in distinct cell populations from normal and diseased colon mucosa.23988185
OsteoporosisEpigenetic AlterationsFurther evaluation of Alu hypomethylation may clarify the epigenetic regulation of osteoporosis in post-menopausal women.23990903
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRs) are small noncoding RNAs that function by suppressing gene expression and are dysregulated in cancer.23991015
Metastasis, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsMicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis.23991015
NeoplasmsEpigenetic AlterationsA simple quantitative diagnostic alternative for MGMT DNA-methylation testing on RCL2 fixed paraffin embedded tumors using restriction coupled qPCR.23993306
Childhood LeukemiaEpigenetic Alterations[MicroRNA-193b expression in newly diagnosed leukemia patients and its significance].23998571
Glioblastoma Multiforme PathwayEpigenetic AlterationsIn order to more thoroughly analyze aberrant DNA methylation in glioma, we applied a large cohort methylation microarray including 119 glioma samples.24002581
Glioblastoma Multiforme PathwayEpigenetic AlterationsEpigenetic silencing of KAZALD1 confers a better prognosis and is associated with malignant transformation/progression in glioma.24002581
CholangiocarcinomaEpigenetic AlterationsGlobal alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway.24002901
Malignant NeoplasmsEpigenetic AlterationsEpigenetic changes such as aberrant hypermethylation and subsequent atypical gene expression are characteristic features of most human cancers.24002901
DNA Mismatch Repair Protein MSH2, human, Basal-Like Breast CarcinomaEpigenetic AlterationsProtein expression and methylation of DNA repair genes hMLH1, hMSH2, MGMT and BRCA1 and their correlation with clinicopathological parameters and prognosis in basal-like breast cancer.24004112
Hollings Cancer CenterEpigenetic AlterationsIn conclusion, our data suggested that epigenetic silencing of TIG1 gene expression by promoter hypermethylation may play an important role in HCC.24006221
Stomach CarcinomaEpigenetic AlterationsDownregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer.24006224
Carcinoma of ampulla of Vater, Pancreatic Neoplasm, PancreatitisEpigenetic AlterationsSerum miRNA was examined by RT-PCR in a group of 49 patients, including 22 with PCs, 6 with benign pancreatic tumors, 7 with ampullary carcinomas, 6 with chronic pancreatitis and 8 healthy participants.24007214
Adenocarcinoma of pancreasEpigenetic AlterationsAnalysis of serum exosomal microRNAs and clinicopathologic features of patients with pancreatic adenocarcinoma.24007214
Carcinogenesis, Adenocarcinoma of pancreasEpigenetic AlterationsAltered expression of serum microRNAs (miRNAs) have been reported to correlate with carcinogenesis and progression of pancreatic adenocarcinoma (PC), but descriptions of serum exosomal miRNAs in PC are still lacking.24007214
Liver carcinomaEpigenetic AlterationsmicroRNA-200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6.24009066
Malignant Neoplasms, DiseaseEpigenetic AlterationsDeregulation of microRNA-200a (miR-200a) has been observed in different types of diseases, including cancers.24009066
Colorectal Cancer PathwayEpigenetic AlterationsRegulation of microRNA-1288 in colorectal cancer: altered expression and its clinicopathological significance.24009195
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAltered microRNA (miRNA) expression is frequently observed in acute myelogenous leukemia (AML) and has been implicated in leukemic transformation.24009227
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAcquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon.24009227
SomaticEpigenetic AlterationsWhether somatic copy number alterations (CNAs) are a frequent cause of altered miRNA gene expression is largely unknown.24009227
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThree other cases of AML were identified with very low to absent miR-223 expression, an miRNA gene known to play a key role in myelopoiesis.24009227
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThese data show that somatic CNAs specifically targeting miRNA genes are uncommon in AML.24009227
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsTo identify clinically relevant tumor suppressor genes silenced by DNA methylation in HCC, we integrated DNA methylation data from human primary HCC samples with data on up-regulation of gene expression after epigenetic unmasking.24012984
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsBased on DNA methylation in primary HCC and gene re-expression in cell lines after epigenetic unmasking, we identified 13 candidate tumor suppressor genes.24012984
Liver carcinoma, NeoplasmsEpigenetic AlterationsGenome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma.24012984
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumor suppressor genes contributes to the pathogenesis of hepatocellular carcinoma (HCC).24012984
Pancreatic carcinomaEpigenetic AlterationsmiRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4.24013097
Pancreatic carcinoma, NeoplasmsEpigenetic AlterationsTherefore, we conclude that miR-141 targets MAP4K4, acts as a tumor suppressor in pancreatic cancer cells, and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy.24013097
Primary malignant neoplasmEpigenetic AlterationsmiRNAs are associated with various types of cancer due to their ability to affect expression of genes that modulate tumorigenesis.24013097
Malignant Neoplasms, Malignant neoplasm of gallbladderEpigenetic AlterationsOther patterns, such as tobacco-related cancers among ArA men and gall bladder and thyroid cancers among ArA women, will require more investigation of genetic, epigenetic, and environmental factors.24013772
Transitional cell carcinoma of ureterEpigenetic AlterationsWe analyzed KLF4 expression and DNA methylation, and their clinical relevance and biological function in urothelial cancer.24018236
Transitional cell carcinoma of ureterEpigenetic AlterationsEpigenetic inactivation of KLF4 is associated with urothelial cancer progression and early recurrence.24018236
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-9 (miR-9) has various expression patterns in diverse human cancers.24019037
Primary malignant neoplasmEpigenetic AlterationsEmerging evidences indicate that dysregulated microRNAs are implicated in cancer tumorigenesis and progression.24019037
Squamous cell carcinoma, Leukoplakia, SERPINB3 wt AlleleEpigenetic AlterationsIncreased expression of microRNAs (miRNAs), miR-21, miR-345, and miR-181b has been demonstrated in oral leukoplakia (OL) that progresses to oral squamous cell carcinoma (OSCC), suggesting a miRNA signature with potential prognostic value.24020903
SERPINB3 wt AlleleEpigenetic AlterationsWe also compared the expression levels of these miRNAs in OL with normal oral mucosa and OSCC.24020903
SERPINB3 wt AlleleEpigenetic AlterationsOSCC cases showed increased expression of all 3 miRNAs when compared with OL and normal oral mucosa.24020903
Adenoma of large intestine, Colorectal Cancer PathwayEpigenetic AlterationsA plasma microRNA panel for detection of colorectal adenomas: a step toward more precise screening for colorectal cancer.24022433
Clinical Coordinator, AdenomaEpigenetic AlterationsAs intended, we undertook a more comprehensive plasma-miRNA screening study in patients with CR adenoma and CRC.24022433
Clinical CoordinatorEpigenetic AlterationsReceiver-operating-characteristic curves of miRNA panels for all CRC versus controls and polyps versus all CRC showed AUC values of 0.829 (95% CI: 0.73-0.93) and 0.856 (95% CI: 0.75-0.97), respectively.24022433
Clinical Coordinator, AdenomaEpigenetic AlterationsWe screened for 380 plasma-miRNAs using microfluidic array technology (Applied BioSystems) in a screening cohort of 12 healthy controls, 9 patients with CR adenomas, and 20 patients with CRC.24022433
Clinical Coordinator, AdenomaEpigenetic AlterationsA panel of the most dysregulated miRNAs (P < 0.05, False Discovery Rate: 5%) was then validated in a blinded cohort of 26 healthy controls, 16 patients with large adenomas, and 45 patients with CRC.24022433
Clinical CoordinatorEpigenetic AlterationsIn addition, a panel of 3 plasma miRNAs (miR-431, miR-15b, and miR-139-3p) distinguished Stage IV CRC from controls with an [AUC = 0.896 (95% CI: 0.78-1.0)].24022433
AdenomaEpigenetic AlterationsPlasma miRNAs are reliable, noninvasive, and inexpensive markers for CR adenomas.24022433
melanomaEpigenetic AlterationsIn-depth characterization of microRNA transcriptome in melanoma.24023765
melanomaEpigenetic AlterationsSurprisingly, the miRNA signature distinguishing specimens of melanoma from nevus was significantly different than that of melanoma cell lines from melanocytes.24023765
melanoma, Primary malignant neoplasmEpigenetic AlterationsFrom this data representing 698 known miRNAs, we defined a set of top-40 list, which properly classified normal from cancer; also confirming 23 (58%) previously discovered miRNAs while introducing an additional 17 (42%) known and top-15 putative novel candidate miRNAs deregulated during melanoma progression.24023765
Nasopharyngeal carcinomaEpigenetic AlterationsDiagnostic and prognostic value of plasma microRNA deregulation in nasopharyngeal carcinoma.24025417
Primary malignant neoplasmEpigenetic AlterationsThere was a negative correlation between plasma miRNA expression and cancer progression, where miR-21 was statistically significant in T and N staging and miR-16 and 24 were significant in N staging only.24025417
Chronic somatic dysfunction, Tubular atrophy, Interstitial Fibrosis AssessmentEpigenetic AlterationsSince microRNAs (miRNAs) have emerged as promising disease biomarkers, we sought to establish an miRNA signature in urinary cell pellets comparing kidney transplant patients diagnosed with chronic allograft dysfunction (CAD) with interstitial fibrosis and tubular atrophy and those recipients with normal graft function.24025639
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNA) have played an important role in carcinogenesis.24025765
MMP8 wt AlleleEpigenetic AlterationsIn summary, our results identify Axl as a key mediator of acquired erlotinib resistance in HNC and suggest that therapeutic inhibition of Axl by small molecule drugs or specific miRNAs might overcome anti-EGFR therapy resistance.24026012
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThese miRNAs are located on chromosome 13 in the 13q14.3 region, which is deleted in more than 55% of CLL patients.24026141
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsRecent studies have revealed that long non-coding RNAs (lncRNAs) play important roles in cancer biology and that lncRNA gas5 (growth arrest-specific 5) regulates breast cancer cell growth.24026436
Stomach CarcinomaEpigenetic AlterationsInhibition of mTOR signalling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation.24030871
Stomach CarcinomaEpigenetic AlterationsThe relationship between mTOR pathway and histone acetylation is still unclear in gastric cancer (GC).24030871
Malignant neoplasm of mouthEpigenetic AlterationsGlobal analysis of DNA methylation changes during progression of oral cancer.24035722
Malignant neoplasm of mouth, Primary malignant neoplasmEpigenetic AlterationsIn identifying aberrant DNA methylation at the earliest stages of oral precancer and finding recurring epigenetic disruption of specific genes/pathways across our analyzed cohort, we see evidence that CpG methylation changes may play a role in oral cancer progression and that global DNA methylation analyses may have significant utility in wider studies that seek to derive biomarkers or potentially druggable targets to improve oral cancer outcomes.24035722
Colorectal Cancer PathwayEpigenetic AlterationsWe provide the first evidence that variations in miRNA-binding sites in BER genes 3-UTR may modulate colorectal cancer prognosis and therapy response.24036853
Primary malignant neoplasmEpigenetic AlterationsAging and cancer demonstrate profound genome-wide DNA methylation changes, suggesting that nutrition may affect the aging process and cancer development through epigenetic mechanisms.24038247
Carcinoma of lungEpigenetic AlterationsIn summary, this study identifies a novel miRNA that targets PKCa and illustrates that the downregulation of PKCa by miR-203 modulates biological processes in lung cancer cells.24040137
Carcinoma of lung, CarcinogenesisEpigenetic AlterationsPKCa (protein kinase C alpha, PRKCA) is an important protein involved in several steps of signaling pathways in lung cancer, and microRNAs (miRNAs) have also been shown to participate in lung carcinogenesis.24040137
Acute GVH diseaseEpigenetic AlterationsPlasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease.24041574
Graft-vs-Host DiseaseEpigenetic AlterationsHere, we show that plasma samples from aGVHD patients have a distinct microRNA (miRNA) expression profile.24041574
Graft-vs-Host DiseaseEpigenetic AlterationsIn addition, the levels of these miRNAs were positively associated with aGVHD severity, and high expression of the miRNA panel was associated with poor overall survival.24041574
Graft-vs-Host DiseaseEpigenetic AlterationsOur results have identified a specific plasma miRNA signature that may serve as an independent biomarker for the prediction, diagnosis, and prognosis of aGVHD.24041574
Graft-vs-Host DiseaseEpigenetic AlterationsWe have developed a model including 4 miRNAs (miR-423, miR-199a-3p, miR-93*, and miR-377) that can predict the probability of aGVHD with an area under the curve of 0.80.24041574
Graft-vs-Host DiseaseEpigenetic AlterationsMoreover, these elevated miRNAs were detected before the onset of aGVHD (median = 16 days before diagnosis).24041574
Astrocytoma, NeoplasmsEpigenetic AlterationsOur results further indicate that epigenetic mechanisms are involved in silencing AKAP12 in diffuse astrocytomas; however, a tumor suppressive role of AKAP12 in distinct astrocytoma subtypes remains to be determined.24042196
Acute lymphocytic leukemiaEpigenetic AlterationsDNA methylation of membrane-bound tyrosine phosphatase genes in acute lymphoblastic leukaemia.24045499
Acute lymphocytic leukemiaEpigenetic AlterationsAberrant DNA promoter methylation with associated gene silencing is a common epigenetic abnormality in acute lymphoblastic leukaemia (ALL) and is associated with poor survival.24045499
Malignant NeoplasmsEpigenetic AlterationsMethylation of the phosphatase promoters was reversible with decitabine and a histone deacetylase inhibitor, suggesting that PTPRK-mediated cell signalling pathways may be targeted with epigenetic therapies in lymphoid malignancy.24045499
Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs), small noncoding RNAs, have been reported to be highly involved in the formation and progression of all types of human cancer including colorectal cancer (CRC).24045965
Colorectal Cancer PathwayEpigenetic AlterationsPrognostic significance of microRNA-16 expression in human colorectal cancer.24045965
Clinical CoordinatorEpigenetic AlterationsTherefore, miRNAs are also potential prognostic biomarkers in CRC patients.24045965
NeoplasmsEpigenetic AlterationsTherefore, we focused on those miRNAs that are relevant to tumor differentiation.24045973
Clinical CoordinatorEpigenetic AlterationsNEK2 may be an independent prognostic factor for CRC and was regulated by miR-128, a microRNA that was subjected to epigenetic regulation.24046120
Colorectal Cancer PathwayEpigenetic AlterationsUp-regulation of NEK2 by microRNA-128 methylation is associated with poor prognosis in colorectal cancer.24046120
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsSubversion of oncogene-induced senescence is a key step during cancer development, and many tumors have lost p16(INK4A) activity by mutation or epigenetic silencing.24046371
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsCell-free plasma microRNA in pancreatic ductal adenocarcinoma and disease controls.24048453
Gastrointestinal DiseasesEpigenetic AlterationsIn the plasma-miRNA population, we find miRNA-375, which is selectively expressed in the endocrine pancreas under normal conditions, increased in PDAC cases compared with patients with other pancreatic or gastrointestinal diseases.24048453
CARCINOMA OF VULVAEpigenetic AlterationsmicroRNA portraits in human vulvar carcinoma.24048714
Human papilloma virus infection, Vulvar NeoplasmsEpigenetic AlterationsOur study characterizes microRNA in vulvar tumors through an expression profile of 754 miRNAs, relating this with clinical and anatomopathologic data, and presence of HPV infection.24048714
CARCINOMA OF VULVAEpigenetic AlterationsA network between microRNA expression profiles and putative target mRNAs predicted by target prediction algorithms and previously demonstrated as relevant in vulvar carcinomas, such as TP53, RB, PTEN, and EGFR was constructed.24048714
CARCINOMA OF VULVA, Primary malignant neoplasmEpigenetic AlterationsIn conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer.24048714
NeoplasmsEpigenetic AlterationsUnregulated expression of microRNAs is well known and has already been demonstrated in many tumor types.24048714
NeoplasmsEpigenetic AlterationsTwenty-five differentially expressed microRNAs between HPV-positive and HPV-negative groups and 79 differentially expressed on the tumor compared with normal samples were obtained.24048714
Idiopathic chronic inflammatory bowel diseaseEpigenetic AlterationsNovel specific microRNA biomarkers in idiopathic inflammatory bowel disease unrelated to disease activity.24051693
Ulcerative Colitis, Crohn DiseaseEpigenetic AlterationsAmong them, a panel of nine miRNAs was aberrantly expressed in both ulcerative colitis and Crohn disease.24051693
Septicemia, RNU6-50P gene, Fibrosis, LiverEpigenetic AlterationsU6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis.24052167
Acute lymphocytic leukemiaEpigenetic AlterationsMicroRNA-142-3p inhibits cell proliferation in human acute lymphoblastic leukemia by targeting the MLL-AF4 oncogene.24057258
HemorrhageEpigenetic AlterationsThe effect of the plasma miRNA level on major adverse cardiovascular events (MACE) within one year and bleeding within six months were assessed.24058072
HemorrhageEpigenetic AlterationsThere was no significant association between the level of five plasma miRNAs and bleeding events during six-month follow-up.24058072
Prostate Cancer PathwayEpigenetic AlterationsGenetic variation in IL-16 miRNA target site and time to prostate cancer diagnosis in African-American men.24061634
Prostate Cancer PathwayEpigenetic AlterationsNo association with time to prostate cancer diagnosis was found for the other miRNA target genotypes.24061634
Prostate Cancer PathwayEpigenetic AlterationsGenetic variation in IL-16 encoding miRNA target site may be informative of time to prostate cancer diagnosis among African-American men enrolled in prostate cancer risk assessment, which may inform individualized prostate cancer screening strategies in the future.24061634
S-AdenosylhomocysteineEpigenetic AlterationsAllelic variants of several enzymes within this pathway have been associated with altered SAM levels either directly, or indirectly as reflected by altered levels of SAH and Homocysteine levels, and altered levels of DNA methylation.24063603
EndometrialEpigenetic AlterationsFinally, the present study suggests that epigenetic alterations may be of diagnostic value for the better clinical management of premalignant endometrial lesions.24068440
Neoplasms, Glioblastoma MultiformeEpigenetic AlterationsThe tumor suppressor microRNA, miR-124a, is regulated by epigenetic silencing and by the transcriptional factor, REST in glioblastoma.24068568
Primary malignant neoplasmEpigenetic AlterationsReduced levels of specific microRNA in cancer are frequently reported and associated with attenuated cancer genes and associated pathways.24068568
Atrial FibrillationEpigenetic AlterationsImpact of microRNA expression in human atrial tissue in patients with atrial fibrillation undergoing cardiac surgery.24069193
Atrial FibrillationEpigenetic AlterationsAlthough microRNA (miRNA) regulates initiation and/or progression of atrial fibrillation (AF) in canine AF models, the underlying mechanism in humans remains unclear.24069193
Fibrosis AssessmentEpigenetic AlterationsPercent fibrosis and miRNA-21 expression were correlated (r=0.508, p<0.05).24069193
Fibrosis AssessmentEpigenetic AlterationsThe expression of miRNA-21 in human atrial tissue was found to be related to atrial fibrosis and might affect AF occurrence, indicating its usefulness as a biomarker for cardiac surgery management.24069193
Stomach CarcinomaEpigenetic AlterationsWe aimed to clarify its epigenetic regulation and biological functions in gastric cancer.24069310
Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsMicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia.24072101
CytogeneticsEpigenetic AlterationsHere we report a potential association between miRNA expression and clinical outcome in 238 intermediate-risk cytogenetic AML (IR-AML) patients from 16 institutions in the CETLAM cooperative group.24072101
Primary Biliary CholangitisEpigenetic AlterationsDecreased expression of miR-let-7b may be associated with development and progression of PBC, and this miRNA may represent a novel target of improved diagnostic and preventive strategies for PBC.24074714
Non-Small Cell Lung CarcinomaEpigenetic AlterationsA prognostic DNA methylation signature for stage I non-small-cell lung cancer.24081945
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsA DNA methylation microarray that analyzes 450,000 CpG sites was used to study tumoral DNA obtained from 444 patients with NSCLC that included 237 stage I tumors.24081945
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe prognostic DNA methylation markers were validated by a single-methylation pyrosequencing assay in an independent cohort of 143 patients with stage I NSCLC.24081945
Non-Small Cell Lung CarcinomaEpigenetic AlterationsUnsupervised clustering of the 10,000 most variable DNA methylation sites in the discovery cohort identified patients with high-risk stage I NSCLC who had shorter relapse-free survival (RFS; hazard ratio [HR], 2.35; 95% CI, 1.29 to 4.28; P = .004).24081945
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe DNA methylation signature of NSCLC affects the outcome of stage I patients, and it can be practically determined by user-friendly polymerase chain reaction assays.24081945
Hypertrophic CardiomyopathyEpigenetic AlterationsMicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations.24083979
Health maintenanceEpigenetic AlterationsTo determine which miRNAs were changed in expression, miRNA arrays were performed on heart tissue from HCM patients with a MYBPC3 mutation (n=6) and compared with hearts of non-failing donors (n=6).24083979
Health maintenanceEpigenetic AlterationsHCM patients with MYBPC3 mutations have a specific miRNA expression profile.24083979
Health maintenanceEpigenetic Alterations13 miRNAs were differentially expressed in HCM compared with donors (at p<0.01, fold change >= 2).24083979
Health maintenanceEpigenetic AlterationsThe genomic context of these differentially expressed miRNAs revealed that miR-204 (fold change 2.4 in HCM vs. donor) was located in an intron of the TRPM3 gene, encoding an aspecific cation channel involved in calcium entry.24083979
Health maintenance, Cardiac HypertrophyEpigenetic AlterationsIn silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor.24083979
Breast CarcinomaEpigenetic AlterationsIdentification of breast cancer DNA methylation markers optimized for fine-needle aspiration samples.24089458
Breast CarcinomaEpigenetic AlterationsUnbiased whole-genome 5-aza-2-deoxycytidine (5AZA)-induced gene expression assays, followed by several phases of qualitative and quantitative methylation-specific PCR (MSP) testing, were used to identify novel breast cancer DNA methylation markers optimized for clinical FNA samples.24089458
Hepatitis BEpigenetic AlterationsHepatitis B virus inhibits apoptosis of hepatoma cells by sponging the MicroRNA 15a/16 cluster.24089558
Metabolic Syndrome XEpigenetic AlterationsCirculating microRNAs have a sex-specific association with metabolic syndrome.24093444
ETV3 wt AlleleEpigenetic AlterationsIn the female subjects, increased expression of both microRNAs was associated with an increased number of MetS risk components (p = 0.002 for let-7 g and p = 0.022 for miR-221).24093444
Disorder of skeletal systemEpigenetic AlterationsContribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders.24096177
Stomach CarcinomaEpigenetic AlterationsContrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer.24097871
Chronic Kidney DiseasesEpigenetic AlterationsOur report raises the possibility that epigenetic dysregulation plays a role in chronic kidney disease development via influencing core pro-fibrotic pathways and can aid the development of novel biomarkers and future therapeutics.24098934
Malignant neoplasm of urinary bladderEpigenetic AlterationsWe previously identified a panel of epigenetic biomarkers (GDF15, TMEFF2 and VIM promoter methylation) that accurately identifies bladder cancer in urine.24100025
Admitting diagnosisEpigenetic AlterationsOur results provide a link between familial AD genes and sporadic neuropathology, thus emphasizing an epigenetic pathomechanism for sporadic AD.24101602
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe quantified miRNA-21 and miRNA-486 expression from plasma and EBC samples from patients with a diagnosis of non-small-cell lung cancer (NSCLC) and controls.24102090
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA-21 was significantly higher in plasma and in EBC of the NSCLC patients and miRNA-486 was significantly lower.24102090
Non-Small Cell Lung CarcinomaEpigenetic AlterationsPlasma and EBC microRNAs as early biomarkers of non-small-cell lung cancer.24102090
Primary malignant neoplasmEpigenetic AlterationsMicro RNAs have called great attention for classification of different cancer types and have been implicated in a range of important biological processes and are deregulated in cancer pathogenesis.24104964
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsMany micro-RNAs (miRNAs) are differentially expressed in Helicobacter pylori-infected gastric mucosa and in gastric cancer tissue and previous reports have suggested the possibility of serum miRNAs as complementary tumour markers.24104965
Malignant NeoplasmsEpigenetic AlterationsSingle-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be related with susceptibility to several human cancers.24107911
Wounds and InjuriesEpigenetic AlterationsIdentification of a miRNA signature in neutrophils after traumatic injury.24108763
Wounds and InjuriesEpigenetic AlterationsHowever, the association between miRNA deregulation and traumatic injury is largely unknown.24108763
Traumatic injuryEpigenetic AlterationsResults showed that 13 miRNAs in neutrophils of major trauma patients were significantly and differentially expressed compared with the miRNA profiles of healthy controls.24108763
Wounds and InjuriesEpigenetic AlterationsIn conclusion, neutrophils associated with traumatic injury were found to have a unique miRNA signature.24108763
Wounds and InjuriesEpigenetic AlterationsThe molecular mechanisms underlying traumatic injury logically involve changes in gene expression that may be regulated through microRNAs (miRNAs).24108763
Wounds and InjuriesEpigenetic AlterationsChanges in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury.24108763
Colorectal NeoplasmsEpigenetic AlterationsThe association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia.24108782
Colorectal Cancer PathwayEpigenetic AlterationsDecreased genomic and increased gene-specific DNA methylation predispose to colorectal cancer.24108782
Carcinoma of lungEpigenetic AlterationsHere we developed and validated a prediction algorithm based on microRNA (miRNA) expression that can assist clinical diagnosis of lung cancer in minimal biopsy material to improve clinical management.24113142
Prostate Cancer PathwayEpigenetic AlterationsWhole-genome methylation sequencing reveals distinct impact of differential methylations on gene transcription in prostate cancer.24113458
Liver carcinomaEpigenetic AlterationsLong noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients.24114970
Hollings Cancer CenterEpigenetic AlterationsRecent evidence highlighted long noncoding RNAs (lncRNAs) as crucial determinants of HCC development.24114970
Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetic priming of AML blasts for all-trans retinoic acid-induced differentiation by the HDAC class-I selective inhibitor entinostat.24116031
Autoimmune Diseases, Lupus ErythematosusEpigenetic AlterationsEpigenetic deregulation of genes encoded on the X chromosome as reported for CD40L in lupus could explain the female predominance of autoimmune diseases.24117612
Inflammation, NeoplasmsEpigenetic AlterationsMicroRNA-218 (miR-218) can function as a tumour suppressor and inactivate cancer-promoting inflammation.24118778
Colorectal Cancer PathwayEpigenetic AlterationsPlasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first-line oxaliplatin-based treatment.24119443
Glioblastoma Multiforme PathwayEpigenetic AlterationsIncreased expression of microRNA-9 predicts an unfavorable prognosis in human glioma.24122417
Glioma, Neoplasms, Glioblastoma MultiformeEpigenetic AlterationsmicroRNA-9 (miR-9) has been found to be upregulated along with tumor progression of gliomas by microarray-based expression profiling, and also be strongly linked to glioblastoma subtypes.24122417
Stomach Carcinoma, MIR20A geneEpigenetic AlterationsWe previously identified five miRNAs (miR-1, miR-20a, miR-27a, miR-34a, and miR-423-5p) that are up-regulated in gastric cancer.24122958
Colorectal Cancer PathwayEpigenetic AlterationsThe relationship between and clinical significance of MicroRNA-32 and phosphatase and tensin homologue expression in colorectal cancer.24123284
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs, miRs) are suspected to play important roles in carcinogenesis.24123284
Liver carcinomaEpigenetic Alterations[Expression of serum microRNAs (miR-222, miR-181, miR-216) in human hepatocellular carcinoma and its clinical significance].24124720
Prostate Cancer PathwayEpigenetic AlterationsProstate cancer cells exposed to epigenetic modifying drugs trichostatin A, alone or combined with 5-aza-2-deoxycytidine, increased H2AFZ transcript, although with a concomitant decrease in protein levels.24127549
Prostate Cancer PathwayEpigenetic AlterationsEpigenetic modifying drugs in conjunction with enzymatic modulators are able to restore the normal functions of sirtuin 1 and might constitute relevant tools for targeted therapy of prostate cancer patients.24127549
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThe specific modification of microRNAs (miRNAs) expression could be a promising strategy in breast cancer therapy, leading to the suppression of tumourigenic processes in tumour cells.24129242
Breast CarcinomaEpigenetic AlterationsConsidering that miR-221/-222 are strongly involved in cell invasion, these miRNAs may be promising markers for breast cancer prognosis and therapy.24129242
Kidney NeoplasmEpigenetic AlterationsMicroRNA profile: a promising ancillary tool for accurate renal cell tumour diagnosis.24129247
Adenocarcinoma of lung, stage IEpigenetic AlterationsEpigenetic inactivation of miR-34b/c by DNA methylation has independent prognostic value in patients with early-stage lung adenocarcinoma.24130071
Adenocarcinoma of lung (disorder)Epigenetic AlterationsEpigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma.24130071
NeoplasmsEpigenetic AlterationsThe microRNA-34b/c (miR-34b/c) is considered a tumor suppressor in different tumor types and a transcriptional target of TP53.24130071
Primary malignant neoplasmEpigenetic AlterationsGlobal decrease in DNA methylation is a common feature of cancer and is associated with genomic and chromosomal instability.24130171
Squamous cell carcinoma of lung, NeoplasmsEpigenetic AlterationsComparisons of microRNA patterns in plasma before and after tumor removal reveal new biomarkers of lung squamous cell carcinoma.24130905
Carcinoma of lungEpigenetic AlterationsHowever, results of multiple previous attempts to identify circulating miRNAs specific for lung cancer are inconsistent, likely due to two main reasons: prominent variability in blood miRNA content among individuals and difficulties in distinguishing tumor-relevant miRNAs in the blood from their non-tumor counterparts.24130905
Squamous cell carcinoma of lung, NeoplasmsEpigenetic AlterationsTo overcome these impediments, we compared circulating miRNA profiles in patients with lung squamous cell carcinoma (SCC) before and after tumor removal, assuming that the levels of all tumor-relevant miRNAs would drop after the surgery.24130905
Carcinoma of lungEpigenetic AlterationsInterestingly, miRNA profiling of plasma fractions of lung SCC patients revealed high levels of these miRNA species in tumor-specific exosomes; additionally, some of these miRNAs were also found to be selectively secreted to the medium by cultivated lung cancer cells.24130905
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThese results strengthen the notion that tumor cells secrete miRNA-containing exosomes into circulation, and that miRNA profiling of the exosomal plasma fraction may reveal powerful cancer biomarkers.24130905
Asthma PathwayEpigenetic AlterationsDNA methylation in the ADRB2 gene is associated with decreased asthma symptom severity, suggesting a role for methylation in asthma phenotypes.24131275
Asthma PathwayEpigenetic AlterationsEpigenetic variation in the ADRB2 may play an important role in asthma phenotype.24131275
NeoplasmsEpigenetic AlterationsThe CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) gene is a novel tumor suppressor with frequent epigenetic inactivation.24131472
Primary malignant neoplasmEpigenetic AlterationsWe found that CMTM3 expression was reduced or silenced by epigenetic regulation in gastric cell lines, and dramatically downregulated in primary gastric cancer tissues.24131472
Primary malignant neoplasmEpigenetic AlterationsThe disease has endemic distribution in the Danube river regions in several Balkan countries.DNA methylation is a primary epigenetic modification that is involved in major processes such as cancer, genomic imprinting, gene silencing, etc.24131581
NeoplasmsEpigenetic AlterationsMicroRNA miR-124 has been suggested as a tumor suppressor for its role in inhibiting cell growth, inducing differentiation and promoting apoptosis.24135052
Bile Duct Neoplasms, Liver carcinomaEpigenetic AlterationsExpression profile of microRNA-200 family in hepatocellular carcinoma with bile duct tumor thrombus.24135722
Metastasis, Hollings Cancer CenterEpigenetic AlterationsEpithelial-to-mesenchymal transition (EMT) is considered a critical step in the progression and metastasis of HCC and is regulated by the microRNA-200 (miR-200) family.24135722
NeoplasmsEpigenetic AlterationsSpecific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours.24136150
Pleural effusion disorder, NeoplasmsEpigenetic AlterationsSHOX2 DNA methylation is a tumour marker in pleural effusions.24136974
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAberrant expression of microRNAs in chronic lymphocytic leukemia (CLL) has been reported to be associated with clinical outcome and improve prognostic stratification.24138306
NeoplasmsEpigenetic AlterationsDysregulation of microRNA let-7a-3 has been identified in several solid tumors and is associated with prognosis of patients.24138945
AlbuminuriaEpigenetic AlterationsDownregulation of Sirt1 and upregulation of the tight junction protein Claudin-1 by SIRT1-mediated epigenetic regulation in podocytes contributed to albuminuria.24141423
Cervical Squamous Cell Carcinoma, Primary malignant neoplasmEpigenetic AlterationsTumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma.24141696
Malignant NeoplasmsEpigenetic AlterationsOur recent studies of microRNA (miRNA) expression signatures indicated that microRNA-29a (miR-29a) was significantly downregulated in several types of human cancers, suggesting that miR-29a may be a putative tumor-suppressive miRNA in human cancers.24141696
cervical cancer, Primary malignant neoplasmEpigenetic AlterationsRestoration of miR-29a in cervical cancer cell lines (CaSKi, HeLa, ME180 and Yumoto) revealed that this miRNA significantly inhibited cancer cell migration and invasion.24141696
MetastasisEpigenetic AlterationsRecognition of tumor-suppressive miRNA-regulated molecular targets provides new insights into the potential mechanisms of cervical SCC oncogenesis and metastasis and suggests novel therapeutic strategies for treatment of this disease.24141696
Malignant Neoplasms, Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsIncreasing epidemiological evidence has indicated that inherited variations of mitochondrial DNA (mtDNA) copy number affect the genetic susceptibility of many malignancies in a tumour-specific manner and that DNA methylation also plays an important role in controlling gene expression during the differentiation and development of hepatocellular carcinoma (HCC).24143196
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRs) play important roles in the development and progression of human cancers.24144839
Carcinogenesis, Primary malignant neoplasm, Ovarian Carcinoma, NeoplasmsEpigenetic AlterationsAltered DNA methylation of tumor suppressor gene promoters probably plays a relevant role in ovarian carcinogenesis and frequently occurs as an early event in the development of different types of cancer including ovarian carcinoma.24145767
Non-Small Cell Lung CarcinomaEpigenetic AlterationsGenetic variation in a microRNA-502 minding site in SET8 gene confers clinical outcome of non-small cell lung cancer in a Chinese population.24146953
Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur data suggested that the rs16917496 T>C located at miR-502 binding site contributes to NSCLC survival by altering SET8 expression through modulating miRNA-target interaction.24146953
Hollings Cancer CenterEpigenetic AlterationsDNA methylation directed repression of BTG3 mRNA expression in HCC cell lines.24147003
Colorectal Cancer PathwayEpigenetic AlterationsOverexpression of microRNA-183 in human colorectal cancer and its clinical significance.24150523
Malignant tumor of colonEpigenetic AlterationsMicroRNA-183 (miR-183) has been shown to play a potential oncogenic role in colon cancer.24150523
LymphomaEpigenetic AlterationsFLIS and PFL had no or few secondary chromosomal imbalances detectable by array comparative genomic hybridization (FLIS 0.8 copy number alterations (CNA)/case; PFL 2.0 CNA/case; mFL 6.3 CNA/case) and a lower level of DNA methylation of genes recurrently de novo methylated in lymphomas, as compared with mFL.24153014
Squamous cell carcinomaEpigenetic AlterationsDNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma.24155659
SERPINB3 wt AlleleEpigenetic AlterationsDNA methylation profiling was utilized to screen the differentially hypermethylated genes in OSCC.24155659
Admitting diagnosisEpigenetic AlterationsOur results provide a possibility that miRNAs detected in plasma and CSF can serve as biomarkers for AD.24157723
Primary malignant neoplasmEpigenetic AlterationsAdditionally, one new miRNA-like molecule with a potential role in cancer was identified in the cell lines and clinical samples.24160351
Squamous cell carcinomaEpigenetic AlterationsHigh-throughput sequencing of small RNA transcriptomes reveals critical biological features targeted by microRNAs in cell models used for squamous cell cancer research.24160351
DiseaseEpigenetic AlterationsThe implication of post-transcriptional regulation by microRNAs in molecular mechanisms underlying cancer disease is well documented.24160351
Usher SyndromeEpigenetic AlterationsOur results indicate that mutations in the USH2A gene and the resulting phenotype are probably modulated by other variables, such as modifying genes, epigenetics or environmental factors which may be of importance for better understanding the etiology of Usher syndrome.24160897
NeoplasmsEpigenetic AlterationsOur findings confirm frequent presence of certain aberrations and reveal novel candidates for improving prognosis based on genetic and epigenetic tumor features.24162828
Alzheimers Disease", Loading TechniqueEpigenetic AlterationsAlterations in DNA methylation have implicated as an epigenetic event in the pathogenesis of late-onset Alzheimers disease (LOAD).24164934
Asthma PathwayEpigenetic AlterationsAberrant epigenetic modifications, such as DNA methylation, may be important in asthma development.24166889
Asthma PathwayEpigenetic AlterationsFetal exposure to maternal asthma during critical periods of in utero development may lead to epigenetic alterations that predispose infants to a greater risk of developing asthma themselves.24166889
Prostate Cancer PathwayEpigenetic AlterationsMicroRNA profiling in prostate cancer--the diagnostic potential of urinary miR-205 and miR-214.24167554
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsROC curve shows that all four miRNAs successfully discriminated between PCa and adjacent normal tissues.24167554
Myocardial fibrosis, Aortic Valve StenosisEpigenetic AlterationsmicroRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-b1 up-regulation.24168656
1-methyl-1-piperidinomethane sulfonateEpigenetic AlterationsmicroRNA-34b/c (miR-34b/c), which plays an important role in the pathogenesis of MPM, is frequently downregulated by DNA methylation in approximately 90% of MPM cases.24168922
Malignant Pleural MesotheliomaEpigenetic AlterationsThe degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma.24168922
Breast CarcinomaEpigenetic AlterationsDifferences in DNA methylation by extent of breast cancer family history in unaffected women.24172832
Breast CarcinomaEpigenetic AlterationsLower global DNA methylation in white blood cells (WBC) has been associated with increased breast cancer risk.24172832
Breast CarcinomaEpigenetic AlterationsWe examined whether WBC DNA methylation varies by extent of breast cancer family history in unaffected women from high-risk breast cancer families.24172832
Breast CarcinomaEpigenetic AlterationsWe used generalized estimated equation models to test for differences in DNA methylation levels by extent of their breast cancer family history after adjusting for age.24172832
Breast CarcinomaEpigenetic AlterationsLINE-1 and Sat2 DNA methylation levels were lower in individuals with 3 or more (3+) first-degree relatives with breast cancer relative to women with only one first-degree relative.24172832
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsIf replicated, these results indicate that lower global WBC DNA methylation levels in families with extensive cancer histories may be one explanation for the clustering of cancers in these families.24172832
Intervertebral Disc DegenerationEpigenetic AlterationsCharacterization of microRNA expression profiles in patients with intervertebral disc degeneration.24173697
Intervertebral disc disorderEpigenetic AlterationsOur results demonstrated that the miRNA expression in patients with IDD differed significantly from that in patients who sustained injury to the intervertebral disc.24173697
Intervertebral disc disorderEpigenetic AlterationsFurther studies on miRNA target gene identification and biological functions may address the specific regulatory mechanisms of miRNAs in IDD, and may provide valuable insight into the diagnosis and treatment of IDD.24173697
Disorder of male reproductive systemEpigenetic AlterationsAccumulating evidence has indicasted that newly defined gene regulators, microRNAs (miRNAs), play a vital role in neurodegenerative, pathophysiological and certain reproductive disorders.24173697
Intervertebral disc disorder, Spinal Cord InjuriesEpigenetic AlterationsAmong the miRNAs analyzed, 25 miRNAs were found to be upregulated and 26 were found to be downregulated in the IDD group compared with the spinal cord injury group.24173697
Intervertebral disc disorderEpigenetic AlterationsOur data indicate that the dysregulated miRNAs control the signaling pathways important for the maintenance of IDD.24173697
Esophageal carcinomaEpigenetic AlterationsInvolvement of microRNA-198 overexpression in the poor prognosis of esophageal cancer.24175778
Esophageal carcinomaEpigenetic AlterationsMicroRNA was extracted from esophageal cancer patients who underwent surgery for assessment using the Taqman@ MicroRNA assay.24175778
ovarian neoplasmEpigenetic AlterationsEpigenetic and expression analysis of TRAIL-R2 and BCL2: on the TRAIL to knowledge of apoptosis in ovarian tumors.24190693
Prostate Cancer PathwayEpigenetic AlterationsOur findings showed Chinese prostate cancer patients have a common and specific miRNA expression profile compared with non-Chinese populations.24191917
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsA total of 28 miRNAs (fold change >= 1.5; P <= 0.05) were differentially expressed between tumor tissue and adjacent benign tissue of 4 prostate cancer patients.10 top Differentially expressed miRNAs were validated by qRT-PCR using all 20 tissue pairs.24191917
Malignant Glioma, Glioblastoma Multiforme PathwayEpigenetic AlterationsHere, we used an integrated approach to identify miRNA functional targets during glioma malignant progression by combining the paired expression profiles of miRNAs and mRNAs across 160 Chinese glioma patients, and further constructed the functional miRNA-mRNA regulatory network.24194606
Glioblastoma Multiforme Pathway, Neoplasms, Malignant GliomaEpigenetic AlterationsGlioma is the most common and fatal primary brain tumour with poor prognosis; however, the functional roles of miRNAs in glioma malignant progression are insufficiently understood.24194606
Glioblastoma Multiforme PathwayEpigenetic AlterationsAs a result, most tumour-suppressive miRNAs in glioma progression were newly discovered, whose functions were widely involved in gliomagenesis.24194606
Colorectal CarcinomaEpigenetic AlterationsMicroRNA-191 correlates with poor prognosis of colorectal carcinoma and plays multiple roles by targeting tissue inhibitor of metalloprotease 3.24195505
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsMicroRNA-191 (miR-191) is reported to be overexpressed in colorectal carcinoma (CRC), but the role of miR-191 in CRC progress remained unclear.24195505
Colorectal Cancer PathwayEpigenetic AlterationsExpression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.24195777
Breast Carcinoma, Mammary NeoplasmsEpigenetic AlterationsAge is a key risk factor for breast cancer and epigenetic alterations may contribute to age-related increases in breast cancer risk, though the relation of age-related methylation in normal breast tissues with altered methylation in breast tumors is unclear.24196486
Cessation of life, Fibrosis AssessmentEpigenetic AlterationsThe autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development.24196965
fibrogenesisEpigenetic AlterationsRecently, microRNA-21 (miR-21) has been found to be prevalently up-regulated during fibrogenesis in different tissues, although its detailed role needs to be further elucidated.24196965
Kidney DiseasesEpigenetic AlterationsMicroRNAs (miRNAs), a family of endogenous small non-coding RNAs, are associated with the development of renal diseases.24198052
Kidney DiseasesEpigenetic AlterationsWe observed 80-99 % of the miRNAs in both the healthy controls and the renal disease patients.24198052
Kidney DiseasesEpigenetic AlterationsThe majority of UmiRNAs displayed higher signal intensity in renal disease patients than in healthy controls, including 39 miRNAs exhibiting signal intensities 100 times greater than in healthy controls.24198052
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAdverse prognostic value of MYBL2 overexpression and association with microRNA-30 family in acute myeloid leukemia patients.24199710
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsProstate cancer (PCa), a leading cause of cancer-related morbidity and mortality, arises through the acquisition of genetic and epigenetic alterations.24200674
InflammationEpigenetic AlterationsHistone acetylation at promoter and enhancer chromosomal regions opens the chromatin and allows access of transcription enzymes to specific genes in rapid response cell signals, such as in inflammation.24204704
diabeticEpigenetic AlterationsPersistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes.24204704
Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8Epigenetic AlterationsUnstimulated (p = 0.140) and GM-CSF-stimulated (p = 0.0485) T1D monocytes, had greater STAT5Ptyr binding to epigenetic regulatory sites upstream of CSF2 than control monocytes.24204704
Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8Epigenetic AlterationsThese findings suggest that the persistent activation of STAT5 by GM-CSF may be involved in altering the epigenetic regulation of these inflammatory response genes in T1D monocytes.24204704
Primary malignant neoplasmEpigenetic AlterationsA key epigenetic alteration involved in the initiation and progression of cancer is aberrant methylation in the promoter region of a gene.24204800
Malignant Head and Neck NeoplasmEpigenetic AlterationsMicroRNA expression profile in head and neck cancer: HOX-cluster embedded microRNA-196a and microRNA-10b dysregulation implicated in cell proliferation.24209638
Malignant NeoplasmsEpigenetic AlterationsCurrent evidence implicates aberrant microRNA expression patterns in human malignancies; measurement of microRNA expression may have diagnostic and prognostic applications.24209638
Squamous cell carcinomaEpigenetic AlterationsMicroRNA expression profile of oral squamous cell carcinoma samples was determined by means of DNA microarrays.24209638
Squamous cell carcinoma of the head and neckEpigenetic AlterationsRoles for microRNAs in head and neck squamous cell carcinomas (HNSCC) are largely unknown.24209638
Carcinoma of lungEpigenetic AlterationsTumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells.24211326
Carcinoma of lungEpigenetic AlterationsMicroRNA-449a (miR-449a) was significantly downregulated in 156 lung cancer tissues (p<0.001).24211326
teratologic, Colorectal CarcinomaEpigenetic AlterationsSubgroups of colorectal carcinomas (CRCs) characterized by DNA methylation anomalies are termed CpG island methylator phenotype (CIMP)1, CIMP2, or CIMP-negative.24211491
NeoplasmsEpigenetic AlterationsA better understanding of the biological determinants of CRCs can be achieved when these tumors are categorized according to their epigenetic status.24211491
Malignant NeoplasmsEpigenetic AlterationsRecent reports suggest that circulating microRNAs (miRNAs) have great potential as biomarkers for diagnosis and prognosis in patients with several types of cancers.24212760
MalnutritionEpigenetic AlterationsThe bone porosity was probably caused by malnutrition that might have had a beneficial effect on longevity of adults, similar to effects of restricted food intake on extending lifespan through epigenetic signatures influencing gene expression.24219154
NeoplasmsEpigenetic AlterationsmiR-21, a putative tumor oncomiR, is a frequently overexpressed miRNA in a variety of tumors.24221338
Breast CarcinomaEpigenetic AlterationsIdentification of androgen-responsive microRNAs and androgen-related genes in breast cancer.24222117
Neoplasms, Hormone-DependentEpigenetic AlterationsThe study of microRNAs has recently provided with important insights into the biology of hormone-dependent cancer.24222117
Breast CarcinomaEpigenetic AlterationsWe examined a possible correlation among microRNAs, target genes, and ARs in breast cancer tissues using immunohistochemistry and laser capture microscopy.24222117
Primary malignant neoplasmEpigenetic AlterationsAlthough microRNAs (miRNA) show potential as diagnostic biomarkers in cancer, their role as circulating cell-free disease response biomarkers remains unknown.24222179
Hodgkin DiseaseEpigenetic AlterationsCandidate circulating miRNA biomarkers for classical Hodgkin lymphoma (cHL) might arise from Hodgkin-Reed-Sternberg (HRS) cells and/or nonmalignant tumor-infiltrating cells.24222179
Stomach CarcinomaEpigenetic AlterationsMicroRNA and protein expression patterns were compared between gastric cancer tissue and normal gastric tissue and between two different prognostic groups.24222951
Stomach CarcinomaEpigenetic AlterationsArray technologies were used to generate 1146 microRNAs and 124 proteins expression profiles of samples from 60 patients with gastric cancer.24222951
Non-Cancer Related Death, Primary malignant neoplasmEpigenetic AlterationsFour microRNAs were aberrantly expressed in the two prognostic groups and in cancer vs non-cancer tissues (P < 0.05).24222951
Rheumatoid Arthritis, NeoplasmsEpigenetic AlterationsThe methylation status of miR-124a seen in this study concurs with that reported in tumor cells, indicating epigenetic dysregulation constituents, a mechanism in the development of rheumatoid arthritis.24223605
ovarian neoplasmEpigenetic AlterationsPlasma miRNAs as diagnostic and prognostic biomarkers for ovarian cancer.24223734
Amyotrophic Lateral SclerosisEpigenetic AlterationsWhole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset.24224837
methionine, Antilymphocyte SerumEpigenetic AlterationsIn conclusion, increased DNA MET % is a possible marker of epigenetic dysfunction in ALS independently of age of onset.24224837
Ovarian CarcinomaEpigenetic AlterationsWe suggest that SAHA may suppress growth, migration and invasion in ovarian carcinoma cells, including cisplatin-resistant or highly-invasive ovarian cells, by promoting histone acetylation and modulating their phenotype-related molecules.24236158
Ischemic strokeEpigenetic AlterationsHowever, the knowledge on the association of plasma miRNAs with ischemic stroke is still lacking.24237608
Anus NeoplasmsEpigenetic AlterationsTotal miRNA was extracted from serum samples in patients with malignant and benign adrenal neoplasms.24238045
SERPINB3 wt AlleleEpigenetic AlterationsThe up-regulated level of microRNA-31 expression may be related to the pathogenesis of OSCC.24238414
Periapical DiseasesEpigenetic AlterationsMicroRNAs: new insights into the pathogenesis of endodontic periapical disease.24238436
Periapical Diseases, InflammationEpigenetic AlterationsMicroRNAs (miRNAs) have been shown to play an important role in the regulation of inflammation and the immune response; however, their role in the pathogenesis of endodontic periapical disease has not been explored.24238436
Carcinoma of larynxEpigenetic AlterationsIdentification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data.24238754
Carcinoma of larynxEpigenetic AlterationsThese two candidate miRNA biomarkers were combined as a single classifier to recognize the biological characteristics in early larynx carcinoma.24238754
Laryngeal neoplasmEpigenetic AlterationsWe identified 47 miRNAs that were significantly differentially expressed in primary larynx tumor tissues compared to normal tissues using a SAM algorithm.24238754
Malignant tumor of colonEpigenetic AlterationsPrognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis.24239208
Stage II Colon Cancer AJCC v7, NeoplasmsEpigenetic AlterationsUsing miRNA microarrays, we analysed 40 paired stage II colon cancer tumours and adjacent normal mucosa tissues, and identified 35 miRNAs that were differentially expressed between tumours and normal tissue.24239208
Malignant tumor of colonEpigenetic AlterationsWe developed two nomograms for clinical use that integrated the six-miRNA-based classifier and four clinicopathological risk factors to predict which patients might benefit from adjuvant chemotherapy after surgery for stage II colon cancer.24239208
Stage II Colon Cancer AJCC v7Epigenetic AlterationsOur six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer, and might be able to predict which patients benefit from adjuvant chemotherapy.24239208
Stage II Colon Cancer AJCC v7Epigenetic AlterationsUsing paraffin-embedded specimens from a further 138 patients with stage II colon cancer, we confirmed differential expression of these miRNAs using qRT-PCR.24239208
Multiple Myeloma, GammopathyEpigenetic AlterationsCirculating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance.24241494
Multiple Myeloma, GammopathyEpigenetic AlterationsEmerging evidence has suggested that circulating microRNAs can serve as minimally invasive biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance.24241494
Multiple Myeloma, GammopathyEpigenetic AlterationsMedian time of remission for both miR-744 and let-7e was approximately 11 months for the low expression and approximately 47 months for the high expression groups of myeloma patients These data demonstrate that expression patterns of circulating microRNAs are altered in multiple myeloma and monoclonal gammopathy of undetermined significance and miR-744 with let-7e are associated with survival of myeloma patients.24241494
Colorectal Cancer PathwayEpigenetic AlterationsAssociation of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway.24242331
Malignant NeoplasmsEpigenetic AlterationsAlthough microRNAs (miRNAs) are useful biomarkers of various cancers, the association between miRNA and BRAF in CRCs is undefined.24242331
Serrated NoduleEpigenetic AlterationsTherefore, this study was conducted to identify a relationship between specific miRNA molecules and BRAF mutation in CRCs and serrated lesions.24242331
AdenomaEpigenetic AlterationsTo assess the identified miRNAs, quantitative reverse transcription-PCR was performed on 721 CRCs, 381 serrated lesions and 251 non-serrated adenomas.24242331
Secondary malignant neoplasm of lungEpigenetic AlterationsA miRNA signature distinguished lung metastases from other metastatic sites.24242678
Primary Neoplasm, Conventional (Clear Cell) Renal Cell Carcinoma, MetastasisEpigenetic AlterationsMicroRNAs with prognostic potential for metastasis in clear cell renal cell carcinoma: a comparison of primary tumors and distant metastases.24242678
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are regulators of gene expression in tumor development and progression.24242678
NeoplasmsEpigenetic AlterationsThere were 14 miRNAs differently expressed in metastatic primary ccRCC and distant metastases compared to non-metastatic primary tumors.24242678
MetastasisEpigenetic AlterationsMiRNAs are deregulated in metastatic primary ccRCC and could be promising prognostic markers for an early prediction of metastasis.24242678
NeoplasmsEpigenetic AlterationsHowever, there is limited understanding regarding the molecular mechanisms of altered methylation, and whether the tumor microenvironment has any effect on DNA methylation and IFNG production.24244422
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsDevelopment of colorectal cancer (CRC) can occur both via gene mutations in tumor suppressor genes and oncogenes, as well as via epigenetic changes, including DNA methylation.24244575
Metabolic DiseasesEpigenetic AlterationsRestoring Dicer levels and the diurnal patterns of Dicer-controlled miRNA and RNA expression may provide new therapeutic strategies for metabolic disease and aging-associated complications.24244599
PseudolymphomaEpigenetic AlterationsEight miRNAs showed statistically significant difference in expression between PTCL-NOS and reactive lymphoid hyperplasia.24246916
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) are emerging as key molecules in human cancer.24247585
Malignant NeoplasmsEpigenetic AlterationsSingle nucleotide polymorphisms (SNPs) in microRNA (miR)-196a-2 have been suggested to contribute to susceptibility to various human cancers.24248733
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1/caspase-9 apoptotic pathway in colorectal cancer cells.24249161
NeoplasmsEpigenetic AlterationsCurrent literature provided information that alteration in microRNA expression impacted sensitivity or resistance of certain tumor types to anticancer treatment, including the possible intracellular pathways.24249161
Progranulins, Frontotemporal Lobar DegenerationEpigenetic AlterationsPromoter DNA methylation regulates progranulin expression and is altered in FTLD.24252647
Frontotemporal Lobar DegenerationEpigenetic AlterationsWe analyzed whether DNA methylation in the GRN core promoter restricts GRN expression and, thus, might promote FTLD in the absence of GRN mutations.24252647
Frontotemporal Lobar DegenerationEpigenetic AlterationsThese data suggest that altered DNA methylation is a novel pathomechanism for FTLD that is potentially amenable to targeted pharmacotherapy.24252647
Metastasis, NeoplasmsEpigenetic AlterationsDNA methylation contributes to tumor formation, development and metastasis.24256813
Primary malignant neoplasmEpigenetic AlterationsqRT-PCR, quantitative methylation-specific PCR (qMSP) and pyrosequencing were used to verify gene expression and DNA methylation in cancer cell lines.24256813
DiseaseEpigenetic AlterationsGrowing evidences show that the pathogenesis of majority human diseases is influenced by the abnormalities of epigenetic and genetic mechanism.24257350
Malignant Neoplasms, Breast, Malignant neoplasm of liverEpigenetic AlterationsExpression of HOX transcript antisense intergenic RNA (HOTAIR)--a long non-coding RNA--has been examined in a variety of human cancers, and overexpression of HOTAIR is correlated with poor survival among breast, colon, and liver cancer patients.24258260
Angina, UnstableEpigenetic AlterationsDiagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina.24260372
Thymoma, NeoplasmsEpigenetic AlterationsMoreover, epithelial tumours (thymomas) are present in about 10-20% of the patients, and there is indication that changes in DNA methylation might contribute to the risk and progression of thymomas.24260492
Primary malignant neoplasm, Autoimmune stateEpigenetic AlterationsIncreasing evidence suggests a contribution of epigenetic processes in promoting cancer and autoimmunity.24260492
Primary malignant neoplasmEpigenetic AlterationsLet-7 microRNAs (miRNAs) are found in a wide range of species, and alterations of let-7 miRNA family member expression levels in humans are associated with various types of cancer.24264599
Breast Diseases, babaodan capsuleEpigenetic AlterationsWe utilized digoxigenin-labeled locked nucleic acid-miRNA probes to detect let-7b expression in 80 BC and 22 benign breast disease (BBD) histologic specimens by in situ hybridization, and also detect the expression of BSG-a potential target gene of let-7b-by immunohistochemistry.24264599
Chronic Lymphocytic LeukemiaEpigenetic AlterationsWe detected thousands of transcriptional elements differentially expressed between the CLL and normal B cells, including protein-coding genes, noncoding RNAs, and pseudogenes.24265505
Malignant neoplasm of endometriumEpigenetic AlterationsRole of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development.24265601
Primary malignant neoplasmEpigenetic AlterationsAccumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of cancer.24265601
Carcinoma, Transitional CellEpigenetic AlterationsComparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure.24268366
Degenerative polyarthritisEpigenetic AlterationsOA chondrocytes were transfected with a miRNA precursor for hsa-miR-148a or a miRNA precursor negative control.24269634
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsEpigenetic inactivation of SPINT2 is associated with tumor suppressive function in esophageal squamous cell carcinoma.24269829
Malignant NeoplasmsEpigenetic AlterationsGrowing evidence has indicated the important roles for different miRNA species in the development of different cancers.24272087
Squamous cell carcinoma of esophagusEpigenetic AlterationsDifferential expression profiling of microRNAs and their potential involvement in esophageal squamous cell carcinoma.24272087
Hollings Cancer CenterEpigenetic AlterationsArsenic resistance protein 2 (Asr2) was reported to be important for microRNA (miR) biogenesis, and its depletion could reduce the levels of several miRs, including miR-21, which is over-expressed in HCC.24272391
Colorectal Cancer PathwayEpigenetic AlterationsA DNA methylation microarray was used to identify epigenetic differences in oxaliplatin-sensitive and -resistant colorectal cancer cells.24273214
Colorectal Cancer PathwayEpigenetic AlterationsWe found that oxaliplatin resistance in colorectal cancer cells depends on the DNA methylation-associated inactivation of the BRCA1 interactor SRBC gene.24273214
Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic inactivation of the BRCA1 interactor SRBC and resistance to oxaliplatin in colorectal cancer.24273214
Primary Neoplasm, Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsSRBC epigenetic inactivation occurred in primary tumors from a discovery cohort of colorectal cancer patients (29.8%; n = 39 of 131), where it predicted shorter PFS (hazard ratio [HR] = 1.83; 95% confidence interval [CI] = 1.15 to 2.92; log-rank P = .01), particularly in oxaliplatin-treated case subjects for which metastasis surgery was not indicated (HR = 1.96; 95% CI = 1.13 to 3.40; log-rank P = .01).24273214
Hollings Cancer CenterEpigenetic AlterationsMiRNAs showed high accuracy in identifying HCC, and could be a useful screening tool for diagnosing HCC patients.24273935
Primary malignant neoplasmEpigenetic AlterationsThe role of E-cadherin down-regulation in oral cancer: CDH1 gene expression and epigenetic blockage.24274398
GliomaEpigenetic AlterationsCombined aberrant expression of microRNA-214 and UBC9 is an independent unfavorable prognostic factor for patients with gliomas.24277415
NeoplasmsEpigenetic AlterationsMicroRNA-214 (miR-214) plays an important role in tumor cell proliferation, migration and invasion, as well as tumor angiogenesis.24277415
Colorectal CarcinomaEpigenetic AlterationsMicroRNA-338-3p inhibits colorectal carcinoma cell invasion and migration by targeting smoothened.24277750
Colorectal CarcinomaEpigenetic AlterationsThe microRNA-338-3p expression pattern of colorectal carcinoma tissues and cell lines was detected by real-time reverse transcriptase polymerase chain reaction.24277750
Colorectal CarcinomaEpigenetic AlterationsFurthermore, colorectal carcinoma cells were pretreated with or without anti-smoothened-small interfering ribonucleic acid prior to the addition of pre-microRNA-338-3p or anti-microRNA-338-3p.24277750
Colorectal Carcinoma, Metastasis, NeoplasmsEpigenetic AlterationsThe expression of microRNA-338-3p was significantly down-regulated in colorectal carcinoma tissues in comparison with those in the adjacent non-tumorous tissues, and the value was negatively related to advanced tumor, node, metastasis stage and local invasion.24277750
Colorectal CarcinomaEpigenetic AlterationsThe expression of microRNA-338-3p in colorectal carcinoma cells transfected with pre-microRNA-338-3p p was significantly increased.24277750
Colorectal CarcinomaEpigenetic AlterationsFurthermore, over-expression of microRNA-338-3p inhibited the expression of smoothened protein in colorectal carcinoma cells, which showed obviously suppressed invasion and migration ability.24277750
Colorectal CarcinomaEpigenetic AlterationsThe expression of microRNA-338-3p in colorectal carcinoma cells transfected with anti-microRNA-338-3p was significantly decreased.24277750
Colorectal CarcinomaEpigenetic AlterationsMoreover, the down-regulated expression of microRNA-338-3p caused the up-regulated expression of smoothened protein in colorectal carcinoma cells, which showed significantly enhanced invasion and migration ability.24277750
Colorectal CarcinomaEpigenetic AlterationsHowever, anti-smoothened-small interfering ribonucleic acid largely, but not completely, reversed the effects induced by blockage of microRNA-338-3p, suggesting that the regulative effect of microRNA-338-3p on colorectal carcinoma cell invasion and migration was indeed mediated by smoothened.24277750
Colorectal CarcinomaEpigenetic AlterationsMicroRNA-338-3p could inhibit colorectal carcinoma cell invasion and migration by inhibiting smoothened expression.24277750
Tuberculosis, PulmonaryEpigenetic AlterationsmiRNA signatures in sera of patients with active pulmonary tuberculosis.24278252
Primary malignant neoplasmEpigenetic AlterationsOne-carbon metabolism is the basement of nucleotide synthesis and the methylation of DNA linked to cancer risk.24278388
Breast Carcinoma, NeoplasmsEpigenetic AlterationsLoss of microRNA-200a expression correlates with tumor progression in breast cancer.24280074
Malignant NeoplasmsEpigenetic AlterationsThe miRNA-200 family has been shown to play a crucial role in the epithelial to mesenchymal transition in human cancers.24280074
Malignant neoplasm of breast, Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsMiRNA-200a expression was demonstrated in 95.2% of normal breast tissue samples and 80.4% of DCIS, whereas 178 (58.0%) of 307 breast cancers and 83.3% of metastatic lymph node samples lacked miRNA-200a expression (P < 0.001).24280074
NeoplasmsEpigenetic AlterationsMoreover, loss of MiRNA-200a expression correlated with high histologic grade (P = 0.017) and perinodal tumor extension (P = 0.026).24280074
Malignant neoplasm of breast, NeoplasmsEpigenetic AlterationsIn conclusion, loss of miRNA-200a is frequently observed in breast cancers, especially tumors with high grade histology.24280074
Breast CarcinomaEpigenetic AlterationsThese findings suggest that miRNA-200a may play an important role in breast cancer initiation and progression.24280074
Carcinoma of lungEpigenetic AlterationsMeasuring miRNA expression levels in sputum could provide a potential approach for the diagnosis of lung cancer.24281335
Carcinoma of lungEpigenetic AlterationsAs digital PCR becomes more established, it would be a robust tool for quantitative assessment of miRNA copy number in sputum for lung cancer diagnosis.24281335
Carcinoma of lungEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in the initiation and progression of lung cancer.24281335
Carcinoma of lungEpigenetic AlterationsDigital PCR quantification of miRNAs in sputum for diagnosis of lung cancer.24281335
Carcinoma of lungEpigenetic AlterationsWe then used digital PCR to quantify copy number of two lung cancer-associated miRNAs (miR-31 and miR-210) in 35 lung cancer patients and 40 cancer-free controls.24281335
Pathology, Cardiovascular DiseasesEpigenetic AlterationsmiRNAs (microRNAs), the small non-coding RNA molecules that regulate gene expression, have been shown previously to be associated with a broad range of human pathologies, including cardiovascular diseases.24283299
Aortic Aneurysm, AbdominalEpigenetic AlterationsmicroRNA profiling in patients with abdominal aortic aneurysms: the significance of miR-155.24283299
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsHistone methylation and acetylation play important roles in the carcinogenesis and progression of cancer.24283856
Prostate Cancer PathwayEpigenetic AlterationsThe tumor-suppressive microRNA-143/145 cluster inhibits cell migration and invasion by targeting GOLM1 in prostate cancer.24284362
Primary malignant neoplasmEpigenetic AlterationsRestoration of miR-143 or miR-145 in PCa cell lines (PC3 and DU145) revealed that these miRNAs significantly inhibited cancer cell migration and invasion.24284362
Hypertensive diseaseEpigenetic AlterationsDifferential expression of vascular smooth muscle-modulating microRNAs in human peripheral blood mononuclear cells: novel targets in essential hypertension.24284386
Hypertensive diseaseEpigenetic AlterationsOur data provide important evidence that VSMC-modulating microRNAs are closely related to essential hypertension in humans and they may represent potential therapeutic targets in essential hypertension.24284386
GliomaEpigenetic AlterationsGliomas with H3F3A K27M from pediatric or young adult patients had similar, characteristic DNA methylation profiles.24285547
Glioblastoma, GliomaEpigenetic AlterationsIn contrast, thalamic gliomas with wild-type H3F3A had DNA methylation profiles similar to those of hemispheric glioblastomas.24285547
Primary malignant neoplasmEpigenetic AlterationsSmall non-coding microRNAs (miRNAs) are key components of cancer development and are considered as potential biomarkers for cancer diagnosis and for monitoring treatment.24286416
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsEpigenetic marks are extensively altered in cancer but may also change in normal tissues with age, which is the primary risk factor for most cancers.24287154
Malignant neoplasm of breast, Breast Carcinoma, NeoplasmsEpigenetic AlterationsIn conclusion, although most variation in methylation status is present between individual breast cancers, clonal epigenetic heterogeneity is seen within most primary breast carcinomas, indicating that methylation results from a single random sample may not be representative of the whole tumor.24287456
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs are small non-coding RNAs, and it is suggested that knowledge of microRNA expression profiles in cancer may have substantial value for diagnostics.24287458
Rhabdoid Tumor, Sarcoma, EpithelioidEpigenetic AlterationsDifferential microRNA expression profiles between malignant rhabdoid tumor and epithelioid sarcoma: miR193a-5p is suggested to downregulate SMARCB1 mRNA expression.24287458
Rhabdoid TumorEpigenetic AlterationsWe first analyzed microRNA expression profiles in 13 frozen materials (five malignant rhabdoid tumors, two proximal type epithelioid sarcomas, and six conventional type epithelioid sarcomas) and subsequently examined the specific microRNA expressions in 29 paraffin-embedded materials (8 malignant rhabdoid tumors, 13 proximal type epithelioid sarcomas, and 8 conventional type epithelioid sarcomas) and 13 previously described frozen materials by quantitative RT-PCR.24287458
Rhabdoid Tumor, Sarcoma, EpithelioidEpigenetic AlterationsAccording to the unsupervised hierarchical clustering of microRNA, proximal type epithelioid sarcoma and conventional type epithelioid sarcoma were classified into the same category, whereas malignant rhabdoid tumor was a distinct category from both types of epithelioid sarcoma.24287458
Rhabdoid Tumor, Neoplasms, Sarcoma, EpithelioidEpigenetic AlterationsThese results suggest that epithelioid sarcoma, especially proximal type epithelioid sarcoma, and malignant rhabdoid tumor are distinct tumors with respect to the microRNA expression profiles and that miR193a-5p may have an important role in the inhibition of SMARCB1 mRNA expression.24287458
Rhabdoid Tumor, Sarcoma, EpithelioidEpigenetic AlterationsIn addition, when malignant rhabdoid tumor with SMARCB1 gene alterations and proximal type and conventional type epithelioid sarcoma with no SMARCB1 gene alterations were compared, 56 microRNAs were isolated as being significantly different (ANOVA, P<0.05).24287458
Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA) polymorphisms contribute to cancer susceptibility and prognosis.24288122
Squamous cell carcinoma of esophagusEpigenetic AlterationsTaken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy.24288122
Clinical Coordinator, Colorectal Cancer Pathway, Pancreatic carcinomaEpigenetic AlterationsProfiling of DNA methylation status of specific genes is a way to screen for colorectal cancer (CRC) and pancreatic cancer (PC) in blood.24288256
FibromyxosarcomaEpigenetic AlterationsThe new myxofibrosarcoma cell line MUG-Myx1 was established to enrich the bank of publicly available cell lines, with respect to providing comprehensive genetic and epigenetic characterization.24289252
Clinical Coordinator, Malignant NeoplasmsEpigenetic AlterationsWe showed the potential of NPY, PENK, and WIF1 as combined epigenetic markers for CRC diagnosis, both in tissue and serum and tested their use as serum biomarkers in other cancers.24289328
MIR206 wt Allele, melanomaEpigenetic AlterationsMicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D. Expression profiling of microRNAs in melanoma lesional skin biopsies compared with normal donor skin biopsies, as well as melanoma cell lines compared with normal melanocytes, revealed that hsa-miR-206 was down-regulated in melanoma (-75.4-fold, P = 1.7 x 10(-4)).24289491
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-25 (miR-25) has recently been found to be involved in many critical processes in human malignancies.24293092
Cerebrovascular DisordersEpigenetic AlterationsThe level of global DNA methylation may be related to the cerebrovascular disease.24295503
Laryngeal Squamous Cell CarcinomaEpigenetic AlterationsMicroRNA-205 suppresses proliferation and promotes apoptosis in laryngeal squamous cell carcinoma.24297308
NeoplasmsEpigenetic AlterationsMicroRNAs were reported to be involved in the modulation of tumor development.24297308
Malignant neoplasm of mouthEpigenetic AlterationsGenetic variations at microRNA and processing genes and risk of oral cancer.24297336
Primary malignant neoplasmEpigenetic AlterationsGenetic variations at microRNA and microRNA processing genes are known to confer risk of cancer in different populations.24297336
Chronic Obstructive Airway DiseaseEpigenetic AlterationsDNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways.24298892
Chronic Obstructive Airway DiseaseEpigenetic AlterationsOur results indicate that aberrant DNA methylation is (1) a genome-wide phenomenon in small airways of patients with COPD, and (2) associated with altered expression of genes and pathways important to COPD, such as the NF-E2-related factor 2 oxidative response pathway.24298892
Chronic Obstructive Airway DiseaseEpigenetic AlterationsDNA methylation is likely an important mechanism contributing to modulation of genes important to COPD pathology.24298892
Chronic Obstructive Airway DiseaseEpigenetic AlterationsBecause these methylation events may underlie disease-specific gene expression changes, their characterization is a critical first step toward the development of epigenetic markers and an opportunity for developing novel epigenetic therapeutic interventions for COPD.24298892
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAt DNA, mRNA and miRNA levels we could identify molecular markers that discriminated significantly between the various histopathological entities of NSCLC.24299561
Primary malignant neoplasmEpigenetic AlterationsAlternatively, noncoding RNAs (ncRNAs) are emerging as key molecules in human cancer, with the potential to serve as novel markers of disease, e.g.24300377
Papillary thyroid carcinomaEpigenetic AlterationsMicroRNA-222 and microRNA-146b are tissue and circulating biomarkers of recurrent papillary thyroid cancer.24301304
Neoplasms, F9 geneEpigenetic AlterationsPatients with recurrent PTC (Rc-PTC) and those without recurrence (NR-PTC) were retrospectively recruited for a comparison of their tumor miRNA profiles.24301304
Fibrosis AssessmentEpigenetic AlterationsHypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype.24301681
Fibrosis AssessmentEpigenetic AlterationsEpigenetic changes may play an important role in modulating hypoxia-induced fibrosis within the heart.24301681
HypoxiaEpigenetic AlterationsEpigenetic modifications and changes in the epigenetic machinery identified in cardiac fibroblasts during prolonged hypoxia may contribute to the pro-fibrotic nature of the ischemic milieu.24301681
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsRecurrent deletions and somatic mutations in TET2, a gene involved in epigenetic regulation, have been reported in about 20% of adult patients with myelodysplastic syndrome.24301955
Colorectal Cancer PathwayEpigenetic AlterationsCirculating microRNA expressions in colorectal cancer as predictors of response to chemotherapy.24304648
Clinical CoordinatorEpigenetic AlterationsWe identified a group of miRNA predictors in response to chemosensitivity for CRC patients.24304648
Carcinoma of lungEpigenetic AlterationsThe sputum miRNA biomarkers might be useful in improving CT for diagnosis of lung cancer, but further independent validation on an external and prospective cohort of patients is required.24305007
Carcinoma of lungEpigenetic AlterationsAnalysis of MicroRNAs in sputum to improve computed tomography for lung cancer diagnosis.24305007
Carcinoma of lung, NeoplasmsEpigenetic AlterationsWe previously identified 12 microRNAs (miRNAs) whose expressions in tumor tissues were associated with lung cancer.24305007
Carcinoma of lungEpigenetic AlterationsIn a training set consisting of 66 lung cancer patients and 68 cancer-free smokers, 10 of the 12 miRNAs were differentially expressed between the cases and controls (p <= 0.01).24305007
Carcinoma of lungEpigenetic AlterationsFrom the miRNAs, a logistic regression model was built on the basis of miR-31 and miR-210, both of which had the best prediction for lung cancer, producing an area under receiver operating characteristic curve of 0.83.24305007
Carcinoma of lungEpigenetic AlterationsCombined use of the two miRNAs yielded 65.2% sensitivity and 89.7% specificity, CT had 93.9% sensitivity and 83.8% specificity for lung cancer diagnosis.24305007
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsBy miRNA expression profiling of microdissected human tumor biopsy specimens we identified miR-328 as one of the main miRNAs upregulated in invading glioma cells in vivo and further investigated its role in glioma pathogenesis.24305703
GliomaEpigenetic AlterationsMethods We employed miRNA mimics and inhibitors to functionally characterize miR-328, 3 untranslated region luciferase assays, and T-cell factor/lymphoid enhancer factor reporter assays to pinpoint miR-328 targets and signaling pathways, and analyzed miR-328 expression in a large panel of gliomas.24305703
GliomaEpigenetic AlterationsHigh-throughput microRNA profiling of pediatric high-grade gliomas.24305714
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) have been identified as key molecules in gene expression regulation, both in development and in cancer.24305714
Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNA (miRNA) expression is deregulated in many tumors including chronic lymphocytic leukemia (CLL).24306027
Chronic Lymphocytic LeukemiaEpigenetic AlterationsIdentification of novel sequence variations in microRNAs in chronic lymphocytic leukemia.24306027
NeoplasmsEpigenetic AlterationsThe candidate prognostic biomarkers, SMAD4 protein loss (P=.01) in tumor cells and microRNA-21 expression in the stroma (P=.05), also correlated with OS.24306217
Malignant neoplasm of urinary bladderEpigenetic AlterationsWe investigated the relationship between the expression of frequently deregulated microRNAs (miRNAs) as well as their target genes (ZEB1/ZEB2) and bladder cancer histopathological grade in an attempt to find a miRNA that might allow more reliable grading of PUTs.24306957
Papillary neoplasmEpigenetic AlterationsExpression of miRNAs and ZEB1 and ZEB2 correlates with histopathological grade in papillary urothelial tumors of the urinary bladder.24306957
Bladder NeoplasmEpigenetic AlterationsWe measured the expression levels of four miRNAs (miR-145, miR-205, miR-125b, and miR-200c) in 120 formalin-fixed, paraffin-embedded bladder tumor tissue samples using real-time PCR assays.24306957
CataractEpigenetic AlterationsEpigenetic regulation of aA-crystallin in high myopia-induced dark nuclear cataract.24312600
CRYAA geneEpigenetic AlterationsTo assess the etiology of early-onset dark nucleus in high-myopic patients and its relationship with the epigenetic regulation of aA-crystallin (CRYAA).24312600
Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsSignificance of serum and hepatic microRNA-122 levels in patients with non-alcoholic fatty liver disease.24313922
Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsWe extracted the total RNA, along with preserved miRNAs, from liver biopsy samples of 67 patients with NAFLD.24313922
Non-Small Cell Lung CarcinomaEpigenetic AlterationsEvaluation of long noncoding RNA MALAT1 as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer.24313945
Adenocarcinoma of lung (disorder), Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe long noncoding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) is described as a potential biomarker for NSCLC (non-small cell lung cancer).24313945
ibudilastEpigenetic AlterationsAdditionally, DNA methylation has been reported to be correlated with the development of IBD.24317008
ibudilast, Inflammatory Bowel DiseasesEpigenetic AlterationsMounting evidence suggests that inflammatory bowel disease (IBD) is caused by genetic predisposition of various genes as well as an abnormal interaction with environmental factors, resulting in epigenetic alterations.24317008
Stomach CarcinomaEpigenetic AlterationsRelapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy.24317477
Stomach CarcinomaEpigenetic AlterationsWe examined the microRNA (miRNA) expression of 35 patients who underwent S-1 adjuvant chemotherapy after curative surgery (R0) for pathological stage II or III gastric cancer.24317477
NeoplasmsEpigenetic AlterationsIf tumors showed high expression of 4 miRNAs (miR-92b, 422a, 4732-5p and 4758-3p) their positive predictive value of relapse was 93.8% and negative predictive value was 92.3%.24317477
Squamous cell carcinoma of esophagusEpigenetic AlterationsDNA methylation analysis was performed to determine the regulatory mechanism of DENND2D expression in ESCC.24317529
Squamous cell carcinoma of esophagusEpigenetic AlterationsThese results suggest that the miRNA-196a2 functional polymorphism rs11614913 might be an effective genetic marker for ESCC risk assessment in individuals younger than 60 years of age from a region of high ESCC incidence in northern China.24320161
Malignant Neoplasms, Liver carcinomaEpigenetic AlterationsThe overexpression of microRNA-221 (miR-221) is reported in several human cancers including hepatocellular carcinoma, and its targeting by tailored treatments has been proposed.24324033
palladium, Parkinson DiseaseEpigenetic AlterationsRecent studies suggest that epigenetic factors may play an important role in the pathogenesis of Parkinsons disease (PD).24325350
Primary malignant neoplasmEpigenetic AlterationsThe deregulation of microRNA (miRNA) is associated with multiple processes involved in cancer progression.24325353
Malignant NeoplasmsEpigenetic AlterationsRNase III endonucleases, Dicer and Drosha, are key enzymes for miRNA biogenesis, and it has been reported that altered expressions of these molecules affect the clinical outcomes of patients with various cancers.24325353
Obesity, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsEffects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity.24325907
Obesity, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsOur results provide evidence that a different composition of gut microbiota in obesity and type 2 diabetes affect the epigenetic regulation of genes.24325907
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-21 expression is associated with overall survival in patients with glioma.24326156
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-21 has been proved to be associated with glioma proliferation and invasion; thus, we sought to clarify the clinical value of miR-21 expression in glioma tissues with WHO grade I to IV.24326156
palladiumEpigenetic AlterationsHypomethylation of SNCA intron-1 was detected in PBMCs of PD patients, and DNA methylation levels were associated with Rep1 polymorphism.24326201
Cachexia, LipolysisEpigenetic AlterationsMicroRNA profiling links miR-378 to enhanced adipocyte lipolysis in human cancer cachexia.24326420
Stomach CarcinomaEpigenetic AlterationsThe development of gastric cancer (GC) is a complex multistep process, including numerous genetic and epigenetic changes.24327257
ovarian neoplasmEpigenetic AlterationsOpioid binding protein/cell adhesion molecule-like gene (OPCML) has a tumor-suppressor function in ovarian cancer, and epigenetic inactivation of OPCML induces oncogenic transformation of human ovarian surface epithelial cells.24327526
Diffuse Large B-Cell LymphomaEpigenetic AlterationsActivating mutations of genes involved in the BCR and NF-kB pathways (CD79A, CD79B, MYD88, and CARD11) or in epigenetic regulation (EZH2) have been recently reported, preferentially in one of the two DLBCL subtypes.24327543
CarcinogenesisEpigenetic AlterationsHistotype-specific miRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis.24327568
ACAA1 geneEpigenetic AlterationsAll miRNAs were remarkably up-regulated in ATC samples compared with PTL samples (P < .01).24327568
Malignant neoplasm of liverEpigenetic AlterationsEpigenetic silencing of glutaminase 2 in human liver and colon cancers.24330717
Malignant neoplasm of liver, Primary malignant neoplasmEpigenetic AlterationsImportantly, the lower level of Gls2 in cancer cells was closely correlated to its promoter hypermethylation; and chemical demethylation treatment with 5-aza-2-deoxycytidine (Aza) increased Gls2 mRNA level in both liver and colon cancer cells, indicating that direct epigenetic silencing suppressed Gls2 expression by methylation.24330717
Carcinogenesis, Malignant neoplasm of liver, NeoplasmsEpigenetic AlterationsWe provide evidence showing that epigenetic silencing of Gls2 via promoter hypermethylation is common in human liver and colon cancers and Gls2 appears to be a functional tumor suppressor involved in the liver and colon tumorigenesis.24330717
Colorectal Cancer PathwayEpigenetic AlterationsmiR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression.24330809
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsMicroRNA-133b (miR-133b), which is a muscle-specific microRNA, has been reported to be downregulated in human colorectal carcinoma (CRC) when compared to adjacent non-tumor tissue.24330809
Multiple Chronic Conditions, Cardiovascular Diseases, Primary malignant neoplasmEpigenetic AlterationsDisturbances of DNA methylation have been associated with multiple diseases, including cardiovascular disease, cancer and, as some have suggested, glucometabolic disturbances.24331772
Metabolic Syndrome XEpigenetic AlterationsThis association was mainly attributable to linear associations of two metabolic syndrome components with DNA methylation: fasting plasma glucose (b = -0.02; p = 0.004) and high-density lipoprotein cholesterol (b = 0.07; p = 0.004).24331772
AIDS-Related Hodgkin LymphomaEpigenetic AlterationsDNA methylation profiling can classify HIV-associated lymphomas.24335480
AIDS-Related Hodgkin LymphomaEpigenetic AlterationsDNA methylation profiling indicated that 2541 target sites differed significantly in HIV-associated lymphoma, which may partly explain the poor prognosis.24335480
Sarcoma - category (morphologic abnormality)Epigenetic AlterationsNutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling.24336067
Adrenocortical carcinoma, Adenoma, miR-181b, humanEpigenetic AlterationsIn contrast, of the selected eight miRNAs reported in the literature as differentially expressed in ACT tissues, five (hsa-miR-100, hsa-miR-181b, hsa-miR-184, hsa-miR-210 and hsa-miR-483-5p) showed a statistically significant overexpression in adrenocortical cancer vs adenoma when normalized on hsa-miR-16 as a reference gene.24336071
Liver carcinomaEpigenetic AlterationsmiRNA-302b suppresses human hepatocellular carcinoma by targeting AKT2.24337067
Malignant Neoplasms, Liver carcinomaEpigenetic AlterationsmiRNAs (miR) play a critical role in human cancers, including hepatocellular carcinoma.24337067
Neoplasms, Prostate carcinomaEpigenetic AlterationsComparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing.24337069
Non-Malignant, Prostate carcinomaEpigenetic AlterationsPrevious deep sequencing identified the miRNA profile of prostate carcinoma versus nonmalignant prostate tissue.24337069
Neoplasms, Prostate carcinomaEpigenetic AlterationsHere, we generated miRNA expression profiles of prostate carcinoma by deep sequencing, with increasing tumor stage relative to corresponding nonmalignant and healthy prostate tissue, and detected clearly changed miRNA expression patterns.24337069
NeoplasmsEpigenetic AlterationsThe regulation for other selected miRNAs could, however, not be confirmed by qRT-PCR in individual tumor stages.24337069
Prostate Cancer PathwayEpigenetic AlterationsThese genomic data reveal relevant miRNAs in prostate cancer that may have biomarker and therapeutic potential.24337069
Malignant Head and Neck NeoplasmEpigenetic AlterationsMethylation of CpG islands in the promoter region of genes acts as a significant mechanism of epigenetic gene silencing in head and neck cancer.24337411
Squamous cell carcinoma of esophagusEpigenetic AlterationsUpregulation of the long non-coding RNA PlncRNA-1 promotes esophageal squamous carcinoma cell proliferation and correlates with advanced clinical stage.24337686
Primary malignant neoplasmEpigenetic AlterationsRecent studies revealed that long noncoding RNAs (lncRNAs) play critical regulatory roles in cancer biology.24337686
NeoplasmsEpigenetic AlterationsWe report here the first instance of epigenetic downregulation in NPC tumor biopsies of a key enzyme, CYB5R2, which is responsible for the detoxification of environmental carcinogens.24338690
Hepatitis BEpigenetic AlterationsAssociation of a microRNA-323b polymorphism with the persistence of hepatitis B virus infection by the enhancement of viral replication.24341744
Prostate Cancer PathwayEpigenetic AlterationsEpigenetic regulation of MDR1 gene through post-translational histone modifications in prostate cancer.24344919
CHOANAL ATRESIA, POSTERIOR, Prostate carcinomaEpigenetic AlterationsMDR1 promoter methylation is frequent in prostate carcinoma (PCa), suggesting an epigenetic regulation but no functional correlation has been established.24344919
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsWe aimed to elucidate the epigenetic mechanisms involved in MDR1 deregulation in PCa.24344919
Acute chest painEpigenetic AlterationsDiagnostic and prognostic value of circulating microRNAs in patients with acute chest pain.24345063
Primary Vitreoretinal Lymphoma, UveitisEpigenetic AlterationsPrimary vitreoretinal B-cell lymphoma and uveitis might be characterized by distinct microRNA signatures.24345320
Childhood MedulloblastomaEpigenetic AlterationsEpigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma.24346283
Childhood MedulloblastomaEpigenetic AlterationsThus, re-expression of microRNA-9 may constitute a novel epigenetic regulation strategy against medulloblastoma.24346283
Malignant Neoplasms, Childhood MedulloblastomaEpigenetic AlterationsmicroRNA-9 is a key regulator of neuronal development aberrantly expressed in brain malignancies, including medulloblastoma.24346283
Childhood MedulloblastomaEpigenetic AlterationsThe association of microRNA-9 expression with medulloblastoma patients clinical outcome was assessed, and the impact of microRNA-9 restoration was functionally validated in medulloblastoma cells.24346283
Childhood MedulloblastomaEpigenetic AlterationsHES1 was identified as a direct target of microRNA-9 in medulloblastoma, and restoration of microRNA-9 was shown to trigger cell cycle arrest, to inhibit clonal growth and to promote medulloblastoma cell differentiation.24346283
Childhood Medulloblastoma, NeoplasmsEpigenetic AlterationsmicroRNA-9 is a methylation-silenced tumour suppressor that could be a potential candidate predictive marker for poor prognosis of medulloblastoma.24346283
NeoplasmsEpigenetic AlterationsLoss of microRNA-9 may confer a proliferative advantage to tumour cells, and it could possibly contribute to disease pathogenesis.24346283
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThese data support the notion that epigenetic changes have clinical impact in CLL and may contribute to the identification of novel candidate disease-associated genes potentially useful to predict the clinical outcome of early stage CLL patients.24347044
Adenocarcinoma of large intestineEpigenetic AlterationsIdentification and validation of reference genes for qPCR detection of serum microRNAs in colorectal adenocarcinoma patients.24349425
Adenoma of large intestine, Adenocarcinoma of large intestineEpigenetic AlterationsWe firstly profiled pooled serum of colorectal adenocarcinoma, colorectal adenoma and healthy controls and selected a list of 13 miRNAs as candidate reference genes.24349425
Prostate Cancer PathwayEpigenetic AlterationsAssociation of microRNA-126 expression with clinicopathological features and the risk of biochemical recurrence in prostate cancer patients undergoing radical prostatectomy.24350576
Primary malignant neoplasmEpigenetic AlterationsNumerous studies have suggested that microRNA-126 (miR-126) is involved in development of various cancer types as well as in malignant proliferation and invasion.24350576
NeoplasmsEpigenetic AlterationsEpithelial tumors are thought to accumulate a series of genetic and epigenetic changes as they progress through well-defined clinical and histopathological changes.24351440
Cell of ClaudiusEpigenetic AlterationsMicroRNA expression signatures of stage, grade, and progression in clear cell RCC.24351440
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are involved in the regulation of mRNA expression from many human genes and miRNA expression is dysregulated in cancer.24351440
Malignant NeoplasmsEpigenetic AlterationsPathways predicted as targets of the most significantly dysregulated miRNAs included signaling, epithelial cancers, metabolism, and epithelial to mesenchymal transition.24351440
Diabetes MellitusEpigenetic AlterationsWhile diabetes mellitus affects plasma miRNAs, no data exist on platelet miRNA profiles in this disease.24352417
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsControlled type II diabetes mellitus has no major influence on platelet micro-RNA expression.24352417
Diabetes MellitusEpigenetic AlterationsFunctional annotation of predicted targets for these miRNAs pointed towards an influence of diabetes mellitus on mRNA processing.24352417
Stomach CarcinomaEpigenetic AlterationsMicroRNA profiles of 90 gastric cancer cases identified two microRNA subtypes significantly associated with survival.24352645
Stomach CarcinomaEpigenetic AlterationsIntegrated analysis identified a key microRNA regulatory network likely driving the gastric cancer mesenchymal subtype.24352645
Stomach Carcinoma, MesenchymalEpigenetic AlterationsWe have uncovered a key microRNA regulatory network that defines the mesenchymal gastric cancer subtype significantly associated with poor overall survival in gastric cancer.24352645
Stomach CarcinomaEpigenetic AlterationsRNA and protein expression were analyzed by RT-PCR and tissue microarray, respectively, in a cohort of 385 gastric cancer cases (including the 90 cases for profiling) to validate the key microRNAs and targets in the network.24352645
OsteosarcomaEpigenetic AlterationsClinical significance of microRNA-183/Ezrin axis in judging the prognosis of patients with osteosarcoma.24352761
Osteosarcoma, NeoplasmsEpigenetic AlterationsMicroRNA-183 (miR-183) has been demonstrated to be a tumor suppressor miRNA in inhibition of migration and invasion of osteosarcoma by targeting an oncogene Ezrin.24352761
Chronic Lymphocytic LeukemiaEpigenetic AlterationsEvolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia.24356097
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThese results reveal that although evolution of DNA methylation occurs in high-risk, clinically progressive cases, positive selection of novel methylation patterns entails coevolution of genetic alteration(s) in CLL.24356097
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAlthough clonal selection by genetic driver aberrations in cancer is well documented, the ability of epigenetic alterations to promote tumor evolution is undefined.24356097
Non-Small Cell Lung CarcinomaEpigenetic AlterationsA critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer.24357161
Adenocarcinoma Of EsophagusEpigenetic AlterationsIGFBP7 is associated with poor prognosis in oesophageal adenocarcinoma and is regulated by promoter DNA methylation.24357797
Primary Cutaneous Follicle Center LymphomaEpigenetic AlterationsIn conclusion, PCFCL and PCLBCL-LT differ in their microRNA profiles.24358187
Diffuse Large B-Cell Lymphoma, LymphomaEpigenetic AlterationsAberrant expression of microRNAs is widely accepted to be pathogenetically involved in nodal diffuse large B-cell lymphomas (DLBCLs).24358187
Squamous cell carcinoma of esophagusEpigenetic AlterationsMicroRNA-17, microRNA-18a, and microRNA-19a are prognostic indicators in esophageal squamous cell carcinoma.24360091
Malignant NeoplasmsEpigenetic AlterationsThe members of the microRNA (miR)-17-92 cluster have been reported to be highly expressed in several cancers.24360091
Malignant neoplasm of urinary bladderEpigenetic AlterationsClinical performance and utility of a DNA methylation urine test for bladder cancer.24360662
Lymphoma, Non-Hodgkin, Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma.24362313
Primary malignant neoplasmEpigenetic AlterationsGenes with altered DNA methylation can be used as biomarkers for cancer detection and assessment of prognosis.24362313
Colorectal Cancer PathwayEpigenetic AlterationsEfficacy and feasibility of the epithelial cell adhesion molecule (EpCAM) immunomagnetic cell sorter for studies of DNA methylation in colorectal cancer.24362576
ovarian neoplasmEpigenetic AlterationsTwenty-two miRNAs were differentially expressed between healthy controls and the ovarian cancer group (P<0.05), while a six miRNA profile subset distinguished presurgical plasma from benign and ovarian cancer patients.24366298
ovarian neoplasmEpigenetic AlterationsThere were also significant differences in miRNA profiles in presurgical plasma from women diagnosed with ovarian cancer who had short overall survival when compared to women with long overall survival (P<0.05).24366298
Carcinoma, Ovarian Epithelial, ovarian neoplasmEpigenetic AlterationsOur preliminary data support the utility of circulating plasma miRNAs to distinguish women with ovarian cancer from those with a benign mass and identify women likely to benefit from currently available treatment for serous epithelial ovarian cancer from those who may not.24366298
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRs) are small non-coding RNAs that play important roles in cancer development where they can act as oncogenes or as tumor-suppressors.24370784
Colorectal Cancer PathwayEpigenetic AlterationsDysregulation of microRNA-34a expression in colorectal cancer inhibits the phosphorylation of FAK via VEGF.24370784
Uveal melanomaEpigenetic AlterationsCirculating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.24370793
Cardiac Arrhythmia, IschemiaEpigenetic AlterationsMicroRNA (miR) is emerging as an important regulator of mitochondrial function, arrhythmia, and protection from ischemia and reperfusion.24371264
Primary malignant neoplasmEpigenetic AlterationsBoth genetic and epigenetic changes can contribute to cancer development and progression.24371281
Malignant NeoplasmsEpigenetic AlterationsGiven the vast genetic heterogeneity of human cancers and difficulty to monitor cancer-initiating events in vivo, the precise relationship between acquisition of genetic mutations and the temporal progression of epigenetic alterations in transformed cells is largely unclear.24371281
AMD1 wt AlleleEpigenetic AlterationsAberrant DNA methylation within the promoter of IL17RC in peripheral blood mononuclear cells has recently been reported in AMD.24373284
Impaired cognitionEpigenetic AlterationsOverall, our results indicated that both Trisomy 21 and cognitive impairment were associated with distinct patterns of DNA methylation.24373378
Malignant Head and Neck NeoplasmEpigenetic AlterationsChanges in circulating microRNAs after radiochemotherapy in head and neck cancer patients.24373621
Primary malignant neoplasmEpigenetic AlterationsCirculating microRNAs (miRNAs) are easily accessible and have already proven to be useful as prognostic markers in cancer patients.24373621
Chronic Lymphocytic LeukemiaEpigenetic AlterationsEpigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia--implications on constitutive activation of NFkB pathway.24373626
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsThe miR-9 family microRNAs have been identified as a tumor suppressor miRNA in cancers.24373626
Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsOf the miR-9 family, miR-9-3 is a tumor suppressor miRNA relatively frequently methylated, and hence silenced in CLL; whereas miR-9-1 methylation is rare in CLL.24373626
ovarian neoplasm, NeoplasmsEpigenetic AlterationsLINE1 and Alu repetitive element DNA methylation in tumors and white blood cells from epithelial ovarian cancer patients.24374023
ovarian neoplasm, NeoplasmsEpigenetic AlterationsWe determined whether DNA methylation of repetitive elements (RE) is altered in epithelial ovarian cancer (EOC) patient tumors and white blood cells (WBC), compared to normal tissue controls.24374023
Malignant NeoplasmsEpigenetic AlterationsAberrant DNA methylation on CpG islands is one of the most consistent epigenetic changes in human cancers, and the process of methylation is catalyzed by the DNA methyltransferases DNMT1, DNMT3a, and DNMT3b.24375250
Malignant Neoplasms, CarcinogenesisEpigenetic AlterationsRecent reports demonstrate that deregulation of miR-124a, one of the frequently methylated microRNAs in human cancers, is related to carcinogenesis.24375250
Colorectal Cancer PathwayEpigenetic AlterationsA genetic variant in microRNA target site of TGF-b signaling pathway increases the risk of colorectal cancer in a Chinese population.24375256
Primary malignant neoplasmEpigenetic AlterationsEvidence shows that single-nucleotide polymorphisms in microRNA (miRNA) target sites can create, destroy, or modify the miRNA/mRNA binding, therefore modulating gene expression and affecting cancer susceptibility.24375256
Clinical CoordinatorEpigenetic AlterationsTo test the hypothesis that genetic variants in miRNA target sites in genes of the TGF-b signaling pathway may also be associated with CRC risk, we first systematically scanned the single-nucleotide polymorphisms (SNPs) in genes of TGF-b signaling pathway which potentially affect the miRNA/mRNA bindings.24375256
Clinical Coordinator, CarcinogenesisEpigenetic AlterationsOur study suggested that SNPs in miRNA target sites could contribute to the likelihood of CRC susceptibility and emphasized the important role of polymorphisms at miRNA-regulatory elements in carcinogenesis.24375256
liposarcoma, NeoplasmsEpigenetic AlterationsMicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors.24375455
liposarcomaEpigenetic AlterationsMiRNA signatures of liposarcoma subtypes were established and validated in an independent series of 58 liposarcomas and control tissues.24375455
liposarcomaEpigenetic AlterationsIn conclusion, we show that miRNA expression profiling can be used to discriminate liposarcoma subtypes, which can possibly aid in objective diagnostic decision making.24375455
Carcinogenesis, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have been associated with carcinogenesis in many tumors and may function as tumor suppressor or oncogene.24375455
liposarcomaEpigenetic AlterationsSupervised hierarchical clustering of the most differentially expressed miRNAs (p < 0.0002) distinguished most liposarcoma subtypes and control tissues.24375455
liposarcoma, NeoplasmsEpigenetic AlterationsIn addition, our data indicate that miR-145 and miR-451 act as tumor suppressors in adipose tissue and show that re-expression of these miRNAs could be a promising therapeutic strategy for liposarcomas.24375455
Parkinson DiseaseEpigenetic AlterationsDNA methylation of the MAPT gene in Parkinsons disease cohorts and modulation by vitamin E in vitro.24375821
palladium, Neurodegenerative Disorders, Parkinson DiseaseEpigenetic AlterationsParkinsons disease (PD) is a neurodegenerative disorder for which environmental factors influence disease risk and may act via an epigenetic mechanism.24375821
Hollings Cancer CenterEpigenetic AlterationsThe epigenetic changes observed in this study indicate that HCC tumors exhibit specific DNA methylation signatures with potential clinical applications in diagnosis and prognosis.24377595
Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score.24378410
Leukemia, Myelocytic, AcuteEpigenetic AlterationsA seven-gene score encompassing epigenetic and genetic prognostic information identifies novel AML subsets that are meaningful for treatment guidance.24378410
Primary malignant neoplasmEpigenetic AlterationsThere is increasing evidence that microRNAs (miRNAs) are involved in cancer development and progression.24379138
Refractory Cytopenia of ChildhoodEpigenetic AlterationsOur results, which identified the plasma miR-221/222 at variable levels during RCC development, suggest that these miRNAs may have a potential as noninvasive biomarkers of RCC development.24379138
Glioblastoma MultiformeEpigenetic AlterationsEpigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme.24380367
Glioma, NeoplasmsEpigenetic AlterationsConcomitant microRNA-31 downregulation and radixin upregulation predicts advanced tumor progression and unfavorable prognosis in patients with gliomas.24380686
Glioblastoma Multiforme PathwayEpigenetic AlterationsTo clarify the clinical significance of microRNA-31 (miR-31) and radixin (RDX) in human glioma.24380686
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-210 overexpression predicts poorer prognosis in glioma patients.24382515
Hypoxia, NeoplasmsEpigenetic AlterationsMicroRNA-210 (miR-210) levels are elevated in many tumor types, are frequently associated with hypoxia induction, and are correlated with poor prognosis in many solid tumors.24382515
Prostate Cancer PathwayEpigenetic AlterationsMicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1.24382668
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur previous microarray data showed that microRNA-224 (miR-224) was downregulated in human prostate cancer (PCa) tissues compared with adjacent benign tissues.24382668
Malignant neoplasm of thyroidEpigenetic AlterationsDNA methylation profiling of well-differentiated thyroid cancer uncovers markers of recurrence free survival.24382797
Thyroid NeoplasmEpigenetic AlterationsHere, we investigated the role of aberrant DNA methylation in the development of well-differentiated thyroid tumors.24382797
Primary Neoplasm, Thyroid NeoplasmEpigenetic AlterationsWe performed genome-wide DNA methylation profiling in the largest well-differentiated thyroid tumor series reported to date, comprising 83 primary tumors as well as 8 samples of adjacent normal tissue.24382797
Malignant neoplasm of thyroidEpigenetic AlterationsThis comprehensive study provides insights into the role of DNA methylation in well-differentiated thyroid cancer development and identifies novel markers associated with recurrence-free survival.24382797
Malignant neoplasm of thyroidEpigenetic AlterationsThyroid cancer is a heterogeneous disease with several subtypes characterized by cytological, histological and genetic alterations, but the involvement of epigenetics is not well understood.24382797
Carcinoma, Follicular neoplasm, Neoplasms, AdenomaEpigenetic AlterationsThe epigenetic profiles were closely related to not only tumor histology but also the underlying driver mutation; we found that follicular tumors had higher levels of methylation, which seemed to accumulate in a progressive manner along the tumorigenic process from adenomas to carcinomas.24382797
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations such as DNA methylation are widespread cancer, contributing to tumorigenesis and acting as markers for prognostication.24383114
Colorectal Cancer Pathway, Intestinal CancerEpigenetic AlterationsThe recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer.24384857
Primary malignant neoplasmEpigenetic AlterationsAdditionally, a significant negative correlation was observed between methylation and DCLK1 expression in 74 cancer cell lines derived from 15 different tissues, and gene expression increased significantly after epigenetic drug treatment of initially methylated cancer cell lines.24384857
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, NeoplasmsEpigenetic AlterationsThe purpose of this study is to identify new tumor suppressor miRNA and elucidate its physiological function and mechanism in renal cell carcinoma (RCC).24384875
Malignant NeoplasmsEpigenetic AlterationsAbnormal expression of miRNAs is closely related to a variety of human cancers.24384875
Myeloid Leukemia, ChronicEpigenetic AlterationsA single microRNA signature classified CML from normal was detected.24385111
Myeloid Leukemia, ChronicEpigenetic AlterationsThe results showed that three microRNAs (miR-150, miR-23a, and miR-130a) were identified to significantly decrease in expanded 38 CML patients compared with 90 normal controls.24385111
Childhood Leukemia, NeoplasmsEpigenetic AlterationsAll these results indicated that those three microRNAs could act as a tumor suppressor and their decreased expression might be one of the causes of leukemia.24385111
Pleural Effusion, MalignantEpigenetic AlterationsDiagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant and malignant pleural effusions.24386354
Primary malignant neoplasmEpigenetic AlterationsThe combined analysis of cytology and DNA methylation resulted in an increase of 71% positively classified PEs from cancer patients as compared to cytological analysis alone.24386354
Alzheimers DiseaseEpigenetic AlterationsGlobal changes in DNA methylation and hydroxymethylation in Alzheimers disease human brain.24387984
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsDNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers altered in Alzheimers disease (AD) brain.24387984
Thymic epithelial tumor, NeoplasmsEpigenetic AlterationsA key challenge in diagnosis and treatment of thymic epithelial tumors (TET) is in improving our understanding of the genetic and epigenetic changes of these relatively rare tumors.24388682
Carcinoma of lungEpigenetic AlterationsMethylation quantification using MS-qPCR and pyrosequencing of cytological lymph node samples obtained using echobronchoscopy is feasible if an appropriate DNA concentration is obtained, notably contributing to the identification of epigenetic biomarkers capable of improving decision-making for the benefit of potentially curable lung cancer patients.24388707
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsThe long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1.24388988
melanoma, NeoplasmsEpigenetic AlterationsWe recently reported the loss of 5-hydroxymethylcytosine in melanoma compared with benign nevi and suggested that loss of this epigenetic marker is correlated with tumor virulence based on its association with a worse prognosis.24390216
Malignant NeoplasmsEpigenetic AlterationsChanges in the expression profiles of microRNAs (miRNAs) have been found in many cancers.24390317
Anaplastic astrocytomaEpigenetic AlterationsDecreased expression of microRNA-206 correlates with poor clinical outcome in patients with malignant astrocytomas.24390803
Malignant - descriptor, NeoplasmsEpigenetic AlterationsMicroRNA-206 (miR-206) has been proved to function as a tumor suppressor in several types of human malignant cancers.24390803
Breast CarcinomaEpigenetic AlterationsMiRNA profiling of approximately 380 miRNAs was performed on RNA derived from blood specimens from 10 women with breast cancer and 10 matched controls.24391813
Malignant NeoplasmsEpigenetic AlterationsTheir combined use to normalize expression data enabled the detection of altered target miRNA expression that reliably differentiated between cancers and controls in human blood specimens.24391813
Breast CarcinomaEpigenetic AlterationsIdentification and validation of miRNAs as endogenous controls for RQ-PCR in blood specimens for breast cancer studies.24391813
NeoplasmsEpigenetic AlterationsWe also showed that there are different miRNA expression profiles associated with NPC for tumor tissue and sera.24393330
Nasopharyngeal carcinomaEpigenetic AlterationsMethods and matrices: approaches to identifying miRNAs for nasopharyngeal carcinoma.24393330
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer (CRC) arises as a consequence of genetic events such as gene mutation and epigenetic alteration.24393480
ovarian neoplasmEpigenetic AlterationsmicroRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition.24394555
Malignant Neoplasms, MeningiomaEpigenetic AlterationsTo reveal any possible association between clinical features and promoter hypermethylation of O(6)-methylguanine-DNA methyltransferase (MGMT) as an important epigenetic modification in many human cancers, we also evaluated the methylation status of MGMT in meningiomas by a SYBR-green-based real-time PCR method.24398011
Communicable Diseases, Hollings Cancer CenterEpigenetic AlterationsHowever, there was no significant correlation between aberrant DNA methylation of MMR genes or p16 and HCV infection in related HCC specimens.24400091
HepatocarcinogenesisEpigenetic AlterationsHowever, the proposed HCV dependent promoter methylation of DNA mismatch repair (MMR) genes and thereby enhanced progression of hepatocarcinogenesis has been the subject of controversial discussion.24400091
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumour suppressor genes has been observed in various cancers.24400091
B-Cell LymphomasEpigenetic AlterationsClinical significance and detection of microRNA-21 in serum of patients with diffuse large B-cell lymphoma in Chinese population.24400911
Autoimmune stateEpigenetic AlterationsDisturbed expression of microRNAs (miRNAs) in regulatory T cells (Tregs) leads to development of autoimmunity in experimental mouse models.24401767
NeoplasmsEpigenetic AlterationsHowever, 20% of HPV DNA-positive tumors were negative for p16, with most of these tumors manifesting DNA methylation at the p16 gene promoter.24403267
Initiation, MetastasisEpigenetic AlterationsMicroRNAs (miRNAs) are directly involved in cancer initiation, progression and metastasis.24404590
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsOur previous work described a metastasis-related microRNAs expression profiling and revealed miR-503 regulating metastatic function in hepatocellular carcinoma (HCC) cells.24405610
Hematologic NeoplasmsEpigenetic AlterationsTo determine the changes in the underlying epigenetic landscape responsible for this expression, we characterized expression, DNA methylation and histone modification profiles in 28 hematological cancer cell lines and confirmed the methylation signature in 356 cytogenetically well-characterized primary hematological malignancies.24405639
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDetectable expression of this gene is an excellent marker for minimal residual disease in acute myeloid leukemia (AML), but the underlying epigenetic alterations are unknown.24405639
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDespite high expression of WT1 and AWT1 transcripts in AML-derived cell lines, we observe robust hypermethylation of the AWT1 promoter and an epigenetic switch from a permissive to repressive chromatin structure between normal cells and AML cell lines.24405639
Cervical Squamous Cell CarcinomaEpigenetic AlterationsDifferentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and after surgery.24405714
Female Genital DiseasesEpigenetic AlterationsFinally, we depicted a regulatory network of differentially expressed serum miRNAs, and many possible target genes were predicted in the estrogen-mediated signal pathways, supporting the hypothesis that cervical SCC is a hormone-associated gynecological disease.24405714
NeoplasmsEpigenetic AlterationsThe survival and colonization of tumor cells at new locations involve a variety of complex genetic, epigenetic, and microenvironmental factors.24409330
Glioma, Neoplasms, Glioblastoma MultiformeEpigenetic AlterationsComparing miRNA expression between glioblastoma group and gliomas of grades I-III, 3 miRNAs (miR-10b, mir-34a and miR-101) showed different regulation statuses between high-grade and low-grade tumors.24412053
Neoplastic disease, Glioblastoma MultiformeEpigenetic AlterationsThis study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs.24412053
Neoplastic disease, Glioblastoma MultiformeEpigenetic AlterationsExpression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I-III.24412053
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs could represent putative target molecules, considering their role in tumorigenesis, cancer progression and their specific tissue expression.24412053
NeoplasmsEpigenetic AlterationsAnalysis of expression of microRNAs and genes involved in the control of key signaling mechanisms that support or inhibit development of brain tumors of different grades.24412320
GlioblastomaEpigenetic AlterationsDifferent miRNAs with pro-oncogenic and anti-oncogenic properties have been identified in glioblastomas.24412320
Glioblastoma Multiforme PathwayEpigenetic AlterationsWe also measured expression of six key genes such as PTEN, p21/CDKN1A, MDR1, ABCG2, BAX, and BCL-2 involved in the regulation of critical glioma signaling pathways to establish the effect of miRNAs on these signaling mechanisms.24412320
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsThese observations provide new insights into molecular pathogenic mechanisms of glioma progression and suggest about a potential value of miRNAs as a putative diagnostic marker of brain tumors.24412320
Inflammatory disorderEpigenetic AlterationsSerum levels of microRNA have been proposed as biomarkers in various inflammatory diseases.24413579
SepticemiaEpigenetic AlterationsAmong all regulated microRNAs, miR-133a displayed the most prominent and concordant up-regulation in sepsis, and this microRNA was therefore chosen for further investigation in the human.24413579
SF3B1 wt AlleleEpigenetic AlterationsOur data show consistency in patterns of aberrant DNA methylation in human and mouse MDS and suggest that epigenetically, MDS displays an accelerated aging phenotype.24414704
Papillary thyroid carcinoma, Primary malignant neoplasm, F9 geneEpigenetic AlterationsAberrant DNA methylation is known to be a major factor in oncogenesis and cancer progression, but effects of methylation in papillary thyroid cancer (PTC) are not well defined.24423287
Refractory Cytopenia of ChildhoodEpigenetic AlterationsThe expression of miR-21 and miR-126 was analysed in a large cohort of RCC patients; a combined risk score (CRS)-model was constructed based on expression levels of both miRNAs.24428907
Extracellular MatrixEpigenetic AlterationsmiRNASeq revealed 160 and 147 differentially expressed miRNAs in ICM and NICM, respectively, compared with nonfailing LV.24429688
Extracellular MatrixEpigenetic AlterationsAmong these, only 2 (ICM) and 5 (NICM) miRNAs are normalized with LVAD.24429688
Autoimmune thrombocytopeniaEpigenetic AlterationsAberrant histone methylation in the patients with immune thrombocytopenia.24433164
Colorectal CarcinomaEpigenetic AlterationsIt is uncertain whether synchronous colorectal cancers (S-CRCs) preferentially develop through widespread DNA methylation and whether they have a prognosis worse than solitary CRC.24434431
EncyclopediasEpigenetic AlterationsFurthermore, the targets of this microRNA were predicted through the gateway miRecords and mapped to lung cancer-associated pathways using the KEGG (Kyoto Encyclopedia of Genes and Genomes) database.24438615
Small cell carcinoma of lung, sq. inEpigenetic AlterationsMicroRNA-205 yielded high diagnostic accuracy in discriminating SQ from AC with an area under the curve (AUC) of 0.985, and discriminating SQ from SCLC with an AUC of 0.978 in formalin-fixed paraffin-embedded (FFPE) surgical lung tissues.24438615
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer.24439061
Malignant neoplasm of urinary bladderEpigenetic AlterationsTo analyze microRNA profile in Ta and T1 urinary bladder cancers in combination and separately and to relate this to the risk of later developing higher-stage disease.24439061
Malignant neoplasm of urinary bladderEpigenetic AlterationsFormalin-fixed, paraffin-embedded samples of 44 Ta and 42 T1 bladder cancers representing cases with and without stage progression during follow-up were collected and microRNA expression levels were measured by microarray analysis.24439061
Malignant NeoplasmsEpigenetic AlterationsThe comparison concerning microRNA expression between the progressors and controls in category T1 cancers revealed no significant differences.24439061
NeoplasmsEpigenetic AlterationsLower miR-10a-5p expression in Ta progressing tumors indicates that this microRNA could be important for later malignant potential among this group of patients.24439061
Malignant NeoplasmsEpigenetic AlterationsProfiling revealed that certain microRNAs predicted the risk of developing higher-stage disease among patients with Ta cancers.24439061
Ocular Sebaceous CarcinomaEpigenetic AlterationsHypermethylation of the CDKN2A gene promoter is a frequent epigenetic change in periocular sebaceous carcinoma and is associated with younger patient age.24440092
Ocular Sebaceous CarcinomaEpigenetic AlterationsIn order to clarify and explore the molecular and epigenetic basis of HPV, CDKN2A status and role of microsatellite instability in the development of periocular sebaceous carcinoma, 24 cases of periocular sebaceous carcinoma were analyzed for the expression of p16(INK4a) and mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2) via immunohistochemistry.24440092
NeoplasmsEpigenetic AlterationsHigher frequency of CDKN2A promoter hypermethylation in younger patients implies a significant epigenetic role in tumor development in this age group.24440092
Adrenal Cortical Adenoma, hyperfunctionEpigenetic AlterationsMicroRNA expression patterns associated with hyperfunctioning and non-hyperfunctioning phenotypes in adrenocortical adenomas.24446485
Alcohol abuseEpigenetic AlterationsThe results suggest that miRNA expression profiles can distinguish different subtypes of ACA, which may contribute to a deeper understanding of ACA development and potential therapeutics.24446485
NeoplasmsEpigenetic AlterationsSignificance analysis of microarrays (SAM) was carried out to identify differentially expressed miRNAs between ACA and adrenal cortices or between tumor subtypes.24446485
AdenomaEpigenetic AlterationsSAM analysis identified 40 over-expressed and three under-expressed miRNAs in the adenomas as compared with adrenal references.24446485
Alcohol abuseEpigenetic AlterationsFourteen miRNAs were common among the three ACA subtypes.24446485
NeoplasmsEpigenetic AlterationsFurthermore, we found specific miRNAs associated with different tumor phenotypes.24446485
Crohn DiseaseEpigenetic AlterationsmicroRNAs (miRNAs) have been suggested to be candidates for biomarkers in various diseases including Crohns disease (CD).24447044
Precursor T cell lymphoblastic leukemia/lymphoblastic lymphomaEpigenetic Alterations[Significance of microRNA-16 and bcl-2 expression in T lymphoblastic lymphoma/leukemia and its relation with prognosis].24447552
Non-Small Cell Lung CarcinomaEpigenetic AlterationsPrognostic value of microRNA expression in operable non-small cell lung cancer patients.24448358
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe assessed by quantitative reverse transcription PCR microRNA (miRNA) expression in 273 stage I-IIIA NSCLC samples.24448358
SERPINB3 wt AlleleEpigenetic AlterationsIn the second step, miRNAs with highest predictive value for distant relapse were re-evaluated in formalin-fixed paraffin-embedded material in an independent group of 134 stage I-IIIA SCC patients.24448358
Pancreatic carcinomaEpigenetic AlterationsMicroRNA biomarkers in whole blood for detection of pancreatic cancer.24449318
Pancreatic carcinoma, Pancreatitis, Primary malignant neoplasmEpigenetic AlterationsTo describe differences in microRNA expression in whole blood between patients with pancreatic cancer, chronic pancreatitis, and healthy participants and to identify panels of microRNAs for use in diagnosis of pancreatic cancer compared with the cancer antigen 19-9 (CA19-9).24449318
Pancreatic carcinomaEpigenetic AlterationsIdentification of microRNA panels (classifiers) for diagnosing pancreatic cancer.24449318
Pancreatic carcinomaEpigenetic AlterationsThe discovery cohort demonstrated that 38 microRNAs in whole blood were significantly dysregulated in patients with pancreatic cancer compared with controls.24449318
Rheumatoid Arthritis, InflammationEpigenetic AlterationsA novel p53/microRNA-22/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis.24449575
Autoimmune DiseasesEpigenetic AlterationsOur results not only reveal a novel mechanism whereby p53 is involved in the posttranscriptional regulation of Cyr61 expression via miRNA-22, but also provide a molecular explanation for the role of somatic mutations of p53, which are frequently observed in RA synovial tissue, in the etiology of this autoimmune disease.24449575
Degenerative polyarthritisEpigenetic AlterationsTo investigate the role of the newly discovered epigenetic mark 5-hydroxymethylcytosine (5hmC) and its regulators in altered gene expression in osteoarthritis (OA).24449578
Degenerative polyarthritisEpigenetic AlterationsThis study provides the first evidence of an epigenetic imbalance of the 5hmC homeostasis in OA leading to TET1 down-regulation and 5hmC accumulation.24449578
Vasa Previa, atheroscleroticEpigenetic AlterationsAberrant DNA methylation of the analyzed loci was not established in either the atherosclerotic plaques and in the tissues from the macroscopically unchanged previa vascular wall in the same patients.24450202
Primary malignant neoplasmEpigenetic AlterationsmicroRNAs (miRNAs) are aberrantly expressed in the whole blood of patients suffering from different types of cancer.24452363
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-30c serves as an independent biochemical recurrence predictor and potential tumor suppressor for prostate cancer.24452717
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-30c (miR-30c) acts as a tumor suppressor or a tumor promoter in various human malignancies.24452717
Antilymphocyte SerumEpigenetic AlterationsThese results demonstrate that the expression of two miRNAs (miRNAs miR-b1336 and miR-b2403) whose effect is to stabilize NEFL mRNA are down regulated in ALS, the net effect of which is predicted to contribute directly to the loss of NEFL steady state mRNA which is pathognomic of spinal motor neurons in ALS.24454911
Carcinoma of lungEpigenetic AlterationsmiR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1. microRNAs (miRNAs) are a class of endogenously expressed, small non-coding RNAs that play an important role in the regulation of gene expression at the post-transcriptional level.24456795
Carcinoma of lung, DiseaseEpigenetic AlterationsDysregulation of miRNAs is associated with a variety of diseases, including lung cancer.24456795
1-methyl-1-piperidinomethane sulfonate, Malignant Pleural Mesothelioma, NeoplasmsEpigenetic AlterationsEpigenetic inactivation of tumor suppressor genes is involved in the development of malignant pleural mesothelioma (MPM).24457242
diabeticEpigenetic AlterationsThese results suggest that epigenetic interventions may reverse alterations in human CMSC obtained from diabetic patients.24458358
Stomach CarcinomaEpigenetic AlterationsTumor-associated microRNAs have been detected in serum or plasma, but whether plasma microRNA-21 (miR-21) could be a potential circulating biomarker for gastric cancer (GC) prognosis in Chinese is still uncertain.24460332
Atrial FibrillationEpigenetic AlterationsIn conclusion, miR-150 expression levels in platelets of patients with systolic HF with AF are significantly reduced and correlated to the cell-free circulating levels of this miRNA.24462065
Primary malignant neoplasmEpigenetic AlterationsIn conclusion, we provide evidence that DNA damage responsive microRNAs are frequently misexpressed in human cancer and can modulate chemotherapy sensitivity.24462518
Malignant NeoplasmsEpigenetic AlterationsIn recent years the investigation of malignancy genomics (genetic and epigenetic changes) has become the main focus of scientists because of its high sensitivity and specificity.24464006
Esophageal Basaloid CarcinomaEpigenetic AlterationsDownregulation of sFRP-2 by epigenetic silencing activates the b-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma.24464051
NEFH gene, NeoplasmsEpigenetic AlterationsDNA methylation of the NEFH promoter and loss of expression have previously been shown to activate the AKT/b-catenin pathway in tumor cells.24464810
Refractory Cytopenia of ChildhoodEpigenetic AlterationsWe identified NEFH methylation as a candidate epigenetic marker for prognosis of RCC patients as well as prediction of anti-vascular endothelial growth factor-based therapy response.24464810
Hepatitis B, Liver carcinomaEpigenetic AlterationsAberrant DNA methylation of G-protein-coupled bile acid receptor Gpbar1 (TGR5) is a potential biomarker for hepatitis B Virus associated hepatocellular carcinoma.24465162
Stomach Carcinoma, MetastasisEpigenetic AlterationsMicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer.24465504
Tetranitromethane, MetastasisEpigenetic AlterationsThese patients showed a significantly more advanced stage (TNM stage >= IB, 35.0% vs. 12.8%, p = 0.045) and higher rate of LN metastasis (30.0% vs. 5.1%, p = 0.014) than those with up-regulation of miRNA-135a expression.24465504
MetastasisEpigenetic AlterationsOur results confirm the tumor-suppressive role of miRNA-135a, and demonstrate its role in LN metastasis in EGC.24465504
Stomach Carcinoma, MetastasisEpigenetic AlterationsMicroRNAs (miRNAs) play a critical role in gastric cancer progression and metastasis.24465504
Breast Carcinoma, ovarian neoplasm, NeoplasmsEpigenetic AlterationsMicroRNA-214 (MiR-214) is aberrantly expressed in several human tumors such as ovarian cancer and breast cancer.24465927
Colorectal Cancer PathwayEpigenetic AlterationsThen the expressions of microRNAs (miRNAs) in six pairs of colorectal cancer and normal tissues were determined by miRNA array, and 30 up-regulated miRNAs were found in the colorectal cancer tissues.24468585
Breast CarcinomaEpigenetic AlterationsAssociation of microRNAs and pathologic response to preoperative chemotherapy in triple negative breast cancer: preliminary report.24469723
Prostatic HyperplasiaEpigenetic AlterationsMicroRNAs 143 and 145 may be involved in benign prostatic hyperplasia pathogenesis through regulation of target genes and proteins.24474452
Hyperhomocysteinemia, Cardiovascular DiseasesEpigenetic AlterationsDNA methylation of repetitive elements may explain the relations between dietary intake, hyperhomocysteinemia, and cardiovascular disease risk.24477006
Malignant Neoplasms, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsAberrant expression of microRNAs (miRNAs) has been associated with the pathogenesis of various cancers, including PCa.24477576
Primary malignant neoplasmEpigenetic AlterationsCirculatory forms of miRNAs have been detected in serum and hold promise as minimally invasive cancer biomarkers.24477576
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsCandidate serum miRNAs were detected by using PCR microarray in a learning set of six African American (AA) and six Caucasian American (CA) PCa patients.24477576
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur results demonstrate that the three miRNAs, particularly miR-628-5p, may be further developed as a biomarker, which can serve as novel noninvasive biomarker for PCa diagnosis and prognosis.24477576
Diabetes Mellitus, Non-Insulin-Dependent, Sensitization (observable entity)Epigenetic AlterationsProfiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization.24478399
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsA discriminant function of four miRNAs (miR-140-5p, miR-423-5p, miR-195, and miR-126) was specific for T2D with an accuracy of 89.2% (P < 0.0001).24478399
Breast Carcinoma, NeoplasmsEpigenetic AlterationsDecreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer.24479446
Breast CarcinomaEpigenetic AlterationsmiRNAs have emerged as an attractive candidate for molecular biomarkers and treatment targets in breast cancer, but their role in the progression of triple negative breast cancer remains largely unexplored.24479446
Breast CarcinomaEpigenetic Alterations71 miRNAs were differentially expressed in triple negative breast cancer, the majority of which have previously been associated with breast cancer, including members of the miR-200 family and the miR-17-92 oncogenic cluster, suggesting that the majority of miRNAs involved in the initiation of triple negative breast cancer are not subtype specific.24479446
Malignant neoplasm of breastEpigenetic AlterationsHowever, the repertoire of miRNAs expressed in lymph node negative and lymph node positive triple negative breast cancers were largely distinct from one another.24479446
Breast CarcinomaEpigenetic AlterationsFrom this, 27 miRNAs were identified that are associated with metastatic capability in the triple negative breast cancer subtype.24479446
Breast Carcinoma, MetastasisEpigenetic AlterationsThese results provide novel insight into the repertoire of miRNAs that contribute to the initiation of and progression to lymph node metastasis in triple negative breast cancer and have important implications for the treatment of this breast cancer subtype.24479446
ovarian neoplasmEpigenetic AlterationsIntegrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer.24479488
ovarian neoplasmEpigenetic AlterationsBoth genetic and epigenetic factors influence the development and progression of epithelial ovarian cancer (EOC).24479488
NeoplasmsEpigenetic AlterationsUsing our previously developed BRCA1/2-signatures, we identified 7 non-BRCA1/2 tumors with a BRCA1-like molecular phenotype and provide evidence for epigenetic inactivation of BRCA1 in three of the tumors.24479546
Pathological accumulation of air in tissuesEpigenetic AlterationsMicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression.24479666
Carcinoma of lung, Chronic Obstructive Airway DiseaseEpigenetic AlterationsResected lung from patients with COPD undergoing lung cancer surgery was profiled using miRNA (Agilent Human miRNA profiler G4470 V1.01) and mRNA (OperonV2.0) microarrays.24479666
Chronic Obstructive Airway Disease, Pathological accumulation of air in tissuesEpigenetic AlterationsDifferences in miRNA expression are associated with emphysema severity in COPD patients.24479666
Pathological accumulation of air in tissuesEpigenetic AlterationsFive miRNAs (miR-34c, miR-34b, miR-149, miR-133a and miR-133b) were significantly down-regulated in lung from patients with moderate compared to mild emphysema as defined by gas transfer (p < 0.01).24479666
Stomach Carcinoma, MetastasisEpigenetic AlterationsmiRNA profiling was performed on 12 pairs of samples of gastric cancer with distant metastasis (GC/DM) and gastric cancer with no distant metastasis (GC/NDM); 14 differentially expressed miRNAs were identified for further inspection.24481716
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsDNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer.24481854
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsAlthough miR-10b was identified as an miRNA deregulator expressed in gastric cancer (GC), there also exists some debate on whether miR-10b is acting as tumor suppressor or oncogene in GC.24481854
NeoplasmsEpigenetic AlterationsMicroRNAs act as tumor suppressors or oncogenes.24481854
Triple Negative Breast NeoplasmsEpigenetic AlterationsDownregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.24485087
Triple Negative Breast NeoplasmsEpigenetic AlterationsThis study provides evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrates that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation.24485087
Chronic Obstructive Airway DiseaseEpigenetic AlterationsIn conclusion, functional and epigenetic alterations of COPD fibroblasts can be reprogrammed through formation of iPSCs.24487392
Malignant NeoplasmsEpigenetic AlterationsThe mitogen-activated protein kinase (MAPK) and AKT signaling pathways are downstream of EGFR and deregulated via genetic and epigenetic mechanisms in many human cancers.24487999
Polycystic Kidney, Autosomal DominantEpigenetic AlterationsUrine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline.24489795
Polycystic Kidney, Autosomal DominantEpigenetic AlterationsExpression of the dysregulated miRNA in fetal tubule epithelia resembled ADPKD better than normal adult cells, except let-7i, which was lower in fetal cells.24489795
Kidney Neoplasm, Polycystic Kidney, Autosomal Dominant, Chronic Kidney DiseasesEpigenetic AlterationsWe found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients.24489795
Polycystic Kidney, Autosomal DominantEpigenetic AlterationsConcordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers.24489795
Carcinogenesis, NeoplasmsEpigenetic AlterationsWe found this repressive association in 6/6 patient tumor samples of different Gleason score, suggesting a strong interplay of DNA methylation and EZH2 to silence RARb during prostate tumorigenesis.24492483
Heat (physical force)Epigenetic AlterationsHere we examine genome-wide DNA methylation, first in 50 identical twins discordant for heat pain sensitivity and then in 50 further unrelated individuals.24496475
Low Back Pain, Feel PainEpigenetic AlterationsWhole-blood DNA methylation was characterized at 5.2 million loci by MeDIP sequencing and assessed longitudinally to identify differentially methylated regions associated with high or low pain sensitivity (pain DMRs).24496475
Feel PainEpigenetic AlterationsOur approach identifies epigenetic changes in both novel and established candidate genes that provide molecular insights into pain and may generalize to other complex traits.24496475
CholangiocarcinomaEpigenetic AlterationsHuman bile contains microRNA-laden extracellular vesicles that can be used for cholangiocarcinoma diagnosis.24497320
DiseaseEpigenetic AlterationsLong non-coding RNAs (lncRNAs) are key regulatory molecules involved in a variety of biological processes and human diseases.24497937
Breast CarcinomaEpigenetic AlterationsIdentification and validation of oncologic miRNA biomarkers for luminal A-like breast cancer.24498016
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMiRNAs play regulatory roles in tumor initiation and progression, and altered miRNA expression has been demonstrated in a variety of cancer states presenting the potential for exploitation as cancer biomarkers.24498016
Mammary NeoplasmsEpigenetic AlterationsThe biomarker potential of 4 miRNAs (miR-29a, miR-181a, miR-223 and miR-652) was confirmed by RQ-PCR, with significantly reduced expression in blood of women with Luminal A-like breast tumors compared to healthy controls (p = 0.001, 0.004, 0.009 and 0.004 respectively).24498016
Malignant NeoplasmsEpigenetic AlterationsBinary logistic regression confirmed that combination of 3 of these miRNAs (miR-29a, miR-181a and miR-652) could reliably differentiate between cancers and controls with an AUC of 0.80.24498016
Breast CarcinomaEpigenetic AlterationsFrom an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer.24498016
Mammary NeoplasmsEpigenetic AlterationsThe expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection.24498016
Primary malignant neoplasm, Neoplasm MetastasisEpigenetic AlterationsMicroRNAs (miRNAs) are small, single-stranded, non-coding RNAs that play pivotal roles in human cancer development and progression, such as tumor metastasis.24498348
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsHere, we identified the miRNAs that regulate hepatocellular carcinoma (HCC) cell migration by a high-throughput screening method using the classical wound-healing assay with time-lapse video microscopy and validation with a transwell migration assay.24498348
Hollings Cancer CenterEpigenetic AlterationsEleven miRNAs (miR-134, -146b-3p, -188-3p, -525-3p, -661, -767-5p, -891a, -891b, -1244, -1247 and miR-1471) were found to promote or inhibit HCC cell migration.24498348
Clinical CoordinatorEpigenetic AlterationsPresent results support the hypothesis that DNA methylation in CRC depends from both physiological and environmental factors, with one-carbon metabolism largely involved in this process.24500500
Cerebrovascular accident, ObesityEpigenetic AlterationsEpigenetic patterns of two gene promoters (TNF-a and PON) in stroke considering obesity condition and dietary intake.24500802
Cerebrovascular accidentEpigenetic AlterationsSome causal bases of stroke remain unclear, but the nutritional effects on the epigenetic regulation of different genes may be involved.24500802
methionine, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsGenome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling.24500968
ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsTo define the genome-wide pattern of DNA methylation in pancreatic ductal adenocarcinomas (PDAC), we captured the methylation profiles of 167 untreated resected PDACs and compared them to a panel of 29 adjacent nontransformed pancreata using high-density arrays.24500968
methionineEpigenetic AlterationsBisulfite amplicon deep sequencing and qRT-PCR expression analyses confirmed recurrent perturbation of axon guidance pathway genes SLIT2, SLIT3, ROBO1, ROBO3, ITGA2 and MET and suggests epigenetic suppression of SLIT-ROBO signaling and up-regulation of MET and ITGA2 expression.24500968
ChordomaEpigenetic AlterationsPrognostic significance of miRNA-1 (miR-1) expression in patients with chordoma.24501096
Stomach Carcinoma, S100A4 protein, humanEpigenetic AlterationsThe malignant transformation in gastric cancer is a multistep, complex process caused by numerous genetic and epigenetic changes, and smoking habits clearly effects on the predisposition to gastric cancer.24501797
Ductal CarcinomaEpigenetic AlterationsEpigenetic regulation of DNMT1 was assessed in 85 invasive ductal carcinomas from BRCA1 mutation carriers.24502362
Glioblastoma Multiforme PathwayEpigenetic AlterationsOur work showed the importance of the methylation status of the PDGF-B gene promoter, and suggests that the epigenetic regulation of the PDGF-B gene may serve as a potential therapeutic target for the inhibition of glioma proliferation.24502980
Coinfection, Primary malignant neoplasmEpigenetic AlterationsOur study shows the first evidence of miRNAs specific for co-infection, several of which are correlated with key gene targets demonstrating functional relationships to pathways in cancer, immune-function, and metabolism.24503097
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA signature in metastatic colorectal cancer patients treated with anti-EGFR monoclonal antibodies.24503111
ras GTPase-Activating Proteins, Primary malignant neoplasmEpigenetic AlterationsDespite the voluminous body of observational evidence concerning the role of miRNAs in cancer, significant knowledge gaps remain concerning the molecular circumstances that underlie the miRNA-cancer connection.24503492
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsIdentification of biomarkers that predict responses to hypomethylating agents (HMAs) will allow optimal strategies for epigenetic therapy in myelodysplastic syndromes (MDS) to be established.24503739
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsSerum microRNA-21 as a potential biomarker for response to hypomethylating agents in myelodysplastic syndromes.24503739
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNAs (miRNAs) regulate the biological properties of colorectal cancer (CRC) cells and might serve as potential prognostic factors and therapeutic targets.24504363
Clinical CoordinatorEpigenetic AlterationsIn this study, we therefore globally profiled miRNAs associated with E-cadherin expression in CRC cells in an attempt to identify miRNAs that are associated with aggressive clinical course in CRC patients.24504363
Clinical CoordinatorEpigenetic AlterationsTwo CRC cell lines (Caco-2 and HRT-18) with different E-cadherin expression pattern were profiled for differences in abundance for more than 1000 human miRNAs using microarray technology.24504363
Childhood LeukemiaEpigenetic AlterationsmicroRNA-34a (miRNA-34a) plays an important role in the pathogenesis of leukemia.24504520
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer.24504682
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsA large number of genetic and epigenetic alterations have been found in gastric cancer, but there is remarkably little consensus on the value of individual biomarker in diagnosis and prognosis of this cancer.24505629
Heart failureEpigenetic AlterationsTranscoronary gradient of plasma microRNA 423-5p in heart failure: evidence of altered myocardial expression.24506564
Heart failureEpigenetic AlterationsElevated plasmatic microRNAs (miRs) are observed in heart failure (HF).24506564
Glioblastoma, Primary malignant neoplasmEpigenetic AlterationsGenetic and epigenetic profiling of glioblastomas has provided a comprehensive list of altered cancer genes of which only O(6)-methylguanine-methyltransferase (MGMT) methylation is used thus far as a predictive marker in a clinical setting.24510240
Glioblastoma MultiformeEpigenetic AlterationsWe screened 98 human glioblastoma samples for genetic and epigenetic alterations in 10 genes and chromosomal loci by PCR and multiplex ligation-dependent probe amplification (MLPA).24510240
Glioblastoma MultiformeEpigenetic AlterationsWe tested the association between these genetic and epigenetic alterations and glioblastoma patient survival.24510240
Stomach CarcinomaEpigenetic AlterationsIntegrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer.24510342
CarcinogensEpigenetic AlterationsSeveral miRNAs differentially expressed between HGSC, CCC and OSE have been identified, suggesting a carcinogenetic role for these miRNAs.24512620
Colorectal Cancer PathwayEpigenetic AlterationsThe number of CA tandem repeats (CA)n in a highly polymorphic region of EGFR (epidermal growth factor receptor) intron 1 may affect gene transcription; the potential impact of allelic variants on the efficacy of cetuximab in metastatic colorectal cancer (mCRC) patients is debated for long.24513691
Asthma Pathway, IL13 geneEpigenetic AlterationsAltered microRNA expression of nasal mucosa in long-term asthma and allergic rhinitis.24513959
Chronic Obstructive Airway DiseaseEpigenetic AlterationsHowever, little is known about the differences in miRNA expression in patients with chronic allergic airway disease.24513959
Asthma PathwayEpigenetic AlterationsWith regard to asthma severity, a trend of increased miRNA expression in persistent asthma was seen, whereas the downregulation of certain miRNAs was most distinct in nonpersistent-asthma patients.24513959
Acute myocardial infarctionEpigenetic AlterationsTo confirm these data, we compared selected miRNAs in the plasma of patients with bevacizumab-induced cardiotoxicity with those of 66 patients with acute myocardial infarction (AMI).24515657
CardiotoxicityEpigenetic AlterationsWe identify two miRNAs that are specifically elevated in patients with bevacizumab-induced cardiotoxicity, miR1254 and miRNA579, and miRNA1254 shows the strongest correlation to the clinical diagnosis of bevacizumab-induced cardiotoxicity.24515657
Degenerative polyarthritisEpigenetic AlterationsmiRNA-454 was inversely correlated with severe knee or hip osteoarthritis with an adjusted HR of 0.77 (95% CI 0.61 to 0.97; p=0.028) when normalised to U6.24515954
Degenerative polyarthritisEpigenetic AlterationsSignature of circulating microRNAs in osteoarthritis.24515954
Degenerative polyarthritisEpigenetic AlterationsAmong these microRNAs, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.24515954
Malignant neoplasm of urinary bladderEpigenetic AlterationsReduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11.24516043
NeoplasmsEpigenetic AlterationsSLC7A11 protein and mRNA, and miRNA-27a were quantified in patient tumor material.24516043
Malignant neoplasm of urinary bladderEpigenetic AlterationsOur findings indicate that miRNA-27a negatively regulates SLC7A11 in cisplatin-resistant bladder cancer, and shows promise as a marker for patients likely to benefit from cisplatin-based chemotherapy.24516043
Chronic Kidney DiseasesEpigenetic AlterationsEpigenetic mechanisms may be important in the progression of chronic kidney disease (CKD).24516231
Renal function, Chronic Kidney DiseasesEpigenetic AlterationsEpigenetic modifications may be important in determining the rate of loss of kidney function in patients with established CKD.24516231
Prostate Cancer PathwayEpigenetic AlterationsRecent evidence suggests that the prostate cancer (PCa)-specific up-regulation of certain genes such as AMACR, EZH2, PSGR, PSMA and TRPM8 could be associated with an aberrant expression of non-coding microRNAs (miRNA).24517338
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsConsequently, miRNAs could contribute to oncogenesis and progression of PCa via an altered miRNA-target gene-interaction.24517338
Colorectal NeoplasmsEpigenetic AlterationsValidation of methylation-sensitive high-resolution melting (MS-HRM) for the detection of stool DNA methylation in colorectal neoplasms.24518356
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsMethylation-sensitive high-resolution melting (MS-HRM) is a new technique for assaying DNA methylation, but its feasibility for assaying stool in patients with colorectal cancer (CRC) is unknown.24518356
Prostate Cancer PathwayEpigenetic AlterationsAberrant miRNA expression is associated with prostate cancer pathogenesis.24518785
Prostate Cancer PathwayEpigenetic AlterationsWe identified miRNAs as potential biomarkers for prostate cancer diagnosis and prognosis.24518785
Colorectal Cancer PathwayEpigenetic AlterationsTo identify dysregulated microRNA(miRNA) that can act as novel biomarker for colorectal cancer screening.24519049
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe microRNA expression signature of bladder cancer by deep sequencing: the functional significance of the miR-195/497 cluster.24520312
Malignant neoplasm of urinary bladder, Best Case Imputation TechniqueEpigenetic AlterationsWe determined the genome-wide miRNA expression signature in bladder cancer (BC) by deep sequencing technology.24520312
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTumor suppressive miRNA-mediated cancer pathways provide new insights into the potential mechanisms of BC oncogenesis.24520312
NBEA geneEpigenetic AlterationsAmong the known miRNAs, a total of 60 miRNAs were significantly downregulated in BC compared with NBE.24520312
MetastasisEpigenetic AlterationsIn conclusion, aberrant expression of clustered miRNAs was identified by deep sequencing, and downregulation of miR-195/497 contributed to BC progression and metastasis.24520312
Ulcerative Colitis, NeoplasmsEpigenetic AlterationsNotably, the TET2 epigenetic regulator was one of only two genes more frequently methylated in superficial tumors and the sole gene in low grade UC.24521710
PyelonephritisEpigenetic AlterationsAcute pyelonephritis in renal allografts: a new role for microRNAs?24521778
Clinical CoordinatorEpigenetic AlterationsMoreover, we found the expression of miR-31, a short non-coding RNA which played a critical role in CRC development, was negatively correlated with FIH-1 expression in CRC samples and cell lines.24521875
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-31 contributes to colorectal cancer development by targeting factor inhibiting HIF-1a (FIH-1).24521875
Stomach CarcinomaEpigenetic AlterationsHowever, the significance of lncRNA, especially long intergenic ncRNA (lincRNA, the main type of lncRNA family), in the diagnosis of gastric cancer is largely unknown.24523021
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThis study was designed to detect aberrant miRNA expressions as a potential biomarker for early detection and prognosis prediction of non-small cell lung cancer (NSCLC).24523873
NeoplasmsEpigenetic AlterationsA similar effect was seen in tumours with epigenetic BRCA-1 silencing.24526178
Meningioma, NeoplasmsEpigenetic AlterationsEpigenetic biomarkers such as DNA methylation, which is found in many tumors and is thus important in tumorigenesis can help diagnose meningiomas and predict response to adjuvant chemotherapy.24528051
Childhood Leukemia, NeoplasmsEpigenetic AlterationsAberrant DNA methylation of tumor suppressor genes has been reported in all major types of leukemia with potential involvement in the inactivation of regulatory cell cycle and apoptosis genes.24528084
Acute lymphocytic leukemia, Myeloid Leukemia, Chronic, Chronic Lymphocytic Leukemia, Childhood Leukemia, Leukemia, Myelocytic, AcuteEpigenetic AlterationsHere, we analyzed six key genes (p14, p15, p16, p53, DAPK and TMS1) for DNA methylation using methylation specific PCR to analyze peripheral blood of 78 leukemia patients (24 CML, 25 CLL, 12 AML, and 17 ALL) and 24 healthy volunteers.24528084
Esophageal carcinoma, Squamous cell carcinoma of esophagusEpigenetic AlterationsTo determine whether aberrant miR-34a methylation occurs in esophageal cancer, the DNA methylation of 23 CpGs sites in the miR-34a promoter was quantitatively analyzed in relation to the translation initiation site by MALDI -TOF mass spectrometry in 59 ESCC tissues and 34 normal tissues from the Kazakh population.24528540
Hollings Cancer CenterEpigenetic AlterationsMethylation-specific sequencing and methylation-specific PCR were performed to examine DNA methylation status of the CHD5 promoter in HCC cell lines and samples.24529164
Hollings Cancer CenterEpigenetic AlterationsIn this study, we focused on the epigenetic modification and tumour-suppressive mechanism of CHD5 gene in HCC.24529164
HypermethylationEpigenetic AlterationsThis study is the first to report cerebellar hypermethylation in c9FTD/ALS, and the first to identify a c9FTD patient with aberrant DNA methylation.24530272
Neurodegenerative DisordersEpigenetic AlterationsRepeat expansions, also present in other neurodegenerative diseases, have been shown to alter epigenetic mechanisms and consequently lead to decreased gene expression, while also leading to toxic RNA gain-of-function.24530272
Colorectal Cancer PathwayEpigenetic AlterationsLow expression of microRNA-126 is associated with poor prognosis in colorectal cancer.24532280
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-126 (miR-126) has been reported to be a tumor suppressor that targets CXCR4 in colorectal cancer (CRC) cells.24532280
ovarian neoplasmEpigenetic AlterationsEpigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer.24535937
Aggressive behavior, Refractory Cytopenia of ChildhoodEpigenetic AlterationsEpigenetic alterations in GATA family members may be associated with aggressive tumor phenotypes in RCC, and in the case of GATA5, may serve as a new independent molecular marker for aggressiveness and disease progression.24549248
Liver carcinomaEpigenetic AlterationsDownregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival.24549282
Hollings Cancer CenterEpigenetic AlterationsThe diagnostic value of plasma miRNA-139 for differentiating patients with HCC from the ones with chronic HBV-hepatitis (CH) was analyzed.24549282
Hollings Cancer CenterEpigenetic AlterationsCompared with plasma of chronic HBV-hepatitis, miRNA-139 was lowly expressed in plasma of HCC patients (p<0.010).24549282
Hollings Cancer CenterEpigenetic AlterationsROC analysis of plasma miRNA-139 yielded an AUC of 0.764 (p<0.010) with sensitivity of 80.6% and specificity of 58.1% while differentiating HCC from chronic HBV-hepatitis.24549282
Hollings Cancer CenterEpigenetic AlterationsSubsequently, 31 HCC patients were divided into the low or high expression group based on plasma miRNA-139 level.24549282
Hollings Cancer CenterEpigenetic AlterationsmiRNA-139 was downregulated in the cancerous tissue and plasma of HCC patients.24549282
Hollings Cancer CenterEpigenetic AlterationsPlasma miRNA-139 is a diagnostic biomarker and prognostic factor for HCC.24549282
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) have been frequently reported to be diagnostic biomarkers and prognostic factors for cancer.24549282
Hollings Cancer CenterEpigenetic AlterationsEpigenetic down-regulation of COL1A1 mRNA expression might have a role as a prognostic biomarker of HCC.24552139
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsDNA methylation plays an important role in cancer biology and methylation events are important prognostic and predictive markers in many tumor types.24554053
ovarian neoplasm, NeoplasmsEpigenetic AlterationsEpigenetic silencing of the LDOC1 tumor suppressor gene in ovarian cancer cells.24554348
Autoimmune thyroid diseaseEpigenetic AlterationsmicroRNA expressions in CD4+ and CD8+ T-cell subsets in autoimmune thyroid diseases.24554510
HaitiEpigenetic AlterationsBoth GD and HT showed significantly decreased miRNA 200a_1 and miRNA 200a2* in CD4+-T-cells (mean relative expression 12,57 in HT vs. 19.40 in control group (CG), p=0.0002; 12,10 in GD vs. 19.40 in CG, p=0.0002) and in CD8+-T-cells (13.13 in HT vs. 18,12 in CG, p=0.02; 11.66 in GD vs. 18.12 in CG, p=0.0002).24554510
HaitiEpigenetic AlterationsGD and HT showed significantly decreased miRNA 155_2 and miRNA 155*_1 in HT in CD8+-T-cells (10.69 in HT vs. 11.30 in CG, p=0.01; 10.40 in GD vs. 11.30 in CG, p=0.005).24554510
Thyroid DiseasesEpigenetic AlterationsThey extend our very limited knowledge concerning miRNAs in thyroid diseases.24554510
Alzheimers DiseaseEpigenetic AlterationsDNA methylation of the TNF-a promoter region in peripheral blood monocytes and the cortex of human Alzheimers disease patients.24556805
Admitting diagnosisEpigenetic AlterationsIn AD patients, epigenetic mechanisms of TNF-a gene regulation, like aberrant DNA methylation, are not relevant in blood.24556805
Pathological accumulation of air in tissuesEpigenetic AlterationsA rat model of emphysema was induced by enforced smoking, and the dynamic miRNAs expression profile at different stages of emphysema with varying periods of smoking were analyzed by microarray and quantitative real-time polymerase chain reaction (qRT-PCR).24556821
Pulmonary EmphysemaEpigenetic AlterationsFollowing smoking for varying periods, different severities of lung emphysema were observed in different groups of rats, accompanied by altered levels of some serum miRNAs associated with regulating some pathways.24556821
CarcinogenesisEpigenetic AlterationsEpigenetic alterations, including histone modifications, play an important role during carcinogenesis.24556868
methionineEpigenetic AlterationsHistone methylation levels of MET resembled MIBC.24556868
Chronic Lymphocytic LeukemiaEpigenetic AlterationsEpigenetic inactivation of mir-34b/c in addition to mir-34a and DAPK1 in chronic lymphocytic leukemia.24559316
Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsTaken together, miR-34b/c is a tumor suppressor miRNA frequently methylated, and hence silenced in CLL.24559316
Glioblastoma Multiforme PathwayEpigenetic AlterationsDecreased expression of microRNA-200b is an independent unfavorable prognostic factor for glioma patients.24559637
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in cancer development and prognosis.24563077
Nasopharyngeal carcinomaEpigenetic AlterationsProfiling plasma microRNA in nasopharyngeal carcinoma with deep sequencing.24563490
NeoplasmsEpigenetic AlterationsEpigenetic alterations, especially aberrant DNA methylation, are recognized as common molecular alterations in a variety of tumors and also occur during the development of tumors.24565108
Primary malignant neoplasmEpigenetic AlterationsCGPredictor: a systematic integrated analytic tool for mining and examining genome-scale cancer independent prognostic epigenetic marker panels.24565108
Medullary carcinoma of thyroidEpigenetic AlterationsOverexpression of genes involved in miRNA biogenesis in medullary thyroid carcinomas with RET mutation.24569963
Primary malignant neoplasmEpigenetic AlterationsExpression of genes encoding factors involved in miRNA biogenesis results often deregulated in human cancer and correlates with aggressive clinical behavior.24569963
Aggressive behaviorEpigenetic AlterationsWe then attempted to correlate expression of miRNA biogenesis genes with tumor aggressiveness.24569963
Myeloid neoplasmEpigenetic AlterationsBMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression.24571310
Skin Basal Cell CarcinomaEpigenetic AlterationsEpigenetic alterations in sporadic basal cell carcinomas.24573469
Breast Cancer CellEpigenetic AlterationsRecently, it has become evident that along with genetic mutations epigenetic alterations play a key role in the pathogenesis of human cancer.24573469
MetastasisEpigenetic AlterationsMoreover, our results revealed that abnormal DNA methylation of miR-34a was correlated with lymph metastasis (P = 0.010).24573638
Carcinoma of lungEpigenetic AlterationsmRNA and miRNA analyses in cytologically positive endobronchial ultrasound-guided transbronchial needle aspiration: implications for molecular staging in lung cancer patients.24574164
Sjogrens SyndromeEpigenetic AlterationsGenome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjogrens syndrome.24574234
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miR)-182 is frequently upregulated in cancers, has generally been viewed as an oncogene and is possibly connected to angiogenesis.24575749
Admitting diagnosisEpigenetic AlterationsSerum miRNA panel (or miR-342-3p alone) may serve as a novel, noninvasive biomarker for AD.24577456
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsDNA methylation of tumor suppressor genes (TSGs) represents a frequent and early epigenetic event with potential applications for cancer detection and disease evolution.24577895
Breast CarcinomaEpigenetic AlterationsAberrant DNA methylation status of DNA repair genes in breast cancer treated with neoadjuvant chemotherapy.24581343
Primary Neoplasm, Colorectal Cancer PathwayEpigenetic AlterationsHOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients.24583926
NeoplasmsEpigenetic AlterationsLong non-coding RNA HOTAIR (Homeobox Transcript Antisense Intergenic RNA) overexpression in tumors was previously associated with poor prognosis and higher mortality in different carcinomas.24583926
Stomach CarcinomaEpigenetic AlterationsWe hoped to identify miRNA polymorphism or a combination of several polymorphisms that could serve as biomarkers for predicting the risk of gastric cancer and its precancerous diseases.24586594
PathologyEpigenetic AlterationsCirculating microRNAs (miRNAs) are emerging as promising biomarkers for several pathologies.24588811
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsAberrant DNA methylation plays an important role in genesis of colorectal cancer (CRC).24590867
Small cell carcinoma of lungEpigenetic AlterationsLong noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer.24591352
Fragile X SyndromeEpigenetic AlterationsGreater than 200 CGG repeats in the 5UTR of the FMR1 gene lead to epigenetic silencing and lack of the FMR1 protein, causing fragile X Syndrome.24591415
Liver carcinomaEpigenetic AlterationsMicroRNA expression profiles of circulating microvesicles in hepatocellular carcinoma.24592541
NeoplasmsEpigenetic AlterationsMicrovesicles (MVs) packaged with microribonucleic acids (miRNAs) have been shown to be released mainly from tumor cells.24592541
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsHowever, little information is known for miRNAs from MVs in hepatocellular carcinoma (HCC).24592541
Hollings Cancer CenterEpigenetic AlterationsAmong them, 115 miRNAs were over-expressed with up to 31 fold difference (miR-671-5p) and 127 were down-expressed with up to 0.041 fold difference (miR-432) in HCC.24592541
Hollings Cancer CenterEpigenetic AlterationsThe deregulation of MVs miRNAs and their target genes were closely involved in the pathways of HCC.24592541
Hollings Cancer CenterEpigenetic AlterationsAberrant HCC-MVs miRNAs may play important roles in the development of HCC.24592541
Liver carcinomaEpigenetic AlterationsUpregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma.24593846
Malignant Solid NeoplasmEpigenetic AlterationsAccumulating evidence has shown that up-regulation of microRNA-25(miR-25) is associated with the prognosis of several types of human malignant solid tumors.24593846
Primary malignant neoplasmEpigenetic AlterationsAberrant global DNA methylation is shown to increase cancer risk.24595004
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe findings from this large-scale study suggest that both low and high levels of global DNA methylation are associated with the risk of bladder cancer.24595004
SepticemiaEpigenetic Alterations[Expression of microRNA-155 and regulative T cell in sepsis patients and their relationship].24598292
Carcinoma of lungEpigenetic AlterationsStill, the prognosis remains poor, and we need to know more about the genetic and epigenetic alterations in lung cancer.24599520
Adenocarcinoma of lung (disorder), NeoplasmsEpigenetic Alterations129 microRNAs were significantly differentially expressed in lung adenocarcinomas compared with normal lung tissue, and 17 microRNAs were differentially expressed between EGFR-mutated and EGFR wildtype tumors.24599520
Adenocarcinoma of lung (disorder)Epigenetic AlterationsWe have identified several aberrantly expressed microRNAs that discriminate lung adenocarcinomas from normal lung tissue, and hence may be potential biomarkers for early detection.24599520
Adenocarcinoma of lung (disorder)Epigenetic AlterationsWe have found microRNAs that are differentially expressed between EGFR-mutated and EGFR wildtype lung adenocarcinomas, suggesting that microRNAs can be used as molecular biomarkers in classification.24599520
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsCpG island methylator phenotype of myelodysplastic syndrome identified through genome-wide profiling of DNA methylation and gene expression.24601943
Malignant NeoplasmsEpigenetic AlterationsThe CpG island methylator phenotype (CIMP) is an epigenetic phenomenon and plays an important role in tumourigenesis in various cancers.24601943
IschemiaEpigenetic AlterationsProlonged cold ischemia induces significant transcriptional changes in a small subset of transcripts in the tissue.24602449
Childhood LeukemiaEpigenetic AlterationsmicroRNA-125b promotes leukemia cell resistance to daunorubicin by inhibiting apoptosis.24604579
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsmicroRNA-125b (miR-125b) is overexpressed in several types of cancer and contributes to tumor resistance to chemotherapy.24604579
Primary malignant neoplasmEpigenetic AlterationsHowever, it is in cancer that only two miRNAs of this cluster and its paralogues have been reported so far to regulate TGFbR2.24606633
MetastasisEpigenetic AlterationsA cluster set of 4 TGFbR2-associated miRNAs was identified; they are all from miR-17-92 cluster and its paralogues, of which miR-93 was one of the most significant miRNAs, directly targeting TGFbR2, promoting cell proliferation, invasion and metastasis in vitro and in vivo.24606633
Refractory Cytopenia of ChildhoodEpigenetic AlterationsOur findings indicated that miR-199a-3p target HGF/c-Met signaling pathway which is crucial for RCC development and suggest that miR-199a-3p may serve as a potential target miRNA for RCC therapy.24609899
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAccumulating evidence suggests that miRNAs are involved in cancer development and progression, acting as either tumor suppressors or oncogenes.24609899
Colorectal Cancer PathwayEpigenetic AlterationsRecent studies have tried to associate colorectal cancer with the aberrant expression of several microRNAs.24615484
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are thought to have a role in cancer development.24615520
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsEpigenetic modifiers such as histone deacetylases (HDACs) have come into focus as novel drug targets for cancer therapy due to their functional role in tumor progression.24618845
Carcinoma, Transitional Cell, Renal Cell CarcinomaEpigenetic AlterationsNew miRNA profiles accurately distinguish renal cell carcinomas and upper tract urothelial carcinomas from the normal kidney.24621579
Pancreatic Intraductal Papillary Mucinous Neoplasm, Intestinal-TypeEpigenetic AlterationsElevated expression level of microRNA-196a is predictive of intestinal-type intraductal papillary mucinous neoplasm of the pancreas.24622064
Intestinal metaplasia, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-196a (miR-196a) is up-regulated in Barrett esophagus (characterized by intestinal metaplasia) and in colorectal cancer; this relationship between intestinal characteristics and miR-196a might also be applicable to intestinal-type IPMNs.24622064
Pancreatic Intraductal Papillary Mucinous Neoplasm, NeoplasmsEpigenetic AlterationsAberrant expression of several microRNAs (miRs) has been reported in various neoplasms including intraductal papillary mucinous neoplasms (IPMNs) of the pancreas.24622064
Mammary NeoplasmsEpigenetic AlterationsThe methylation status of the GR promoter was assessed to determine if this observed decrease of expression in breast tumors could be due to epigenetic regulation.24622770
Glioblastoma Multiforme PathwayEpigenetic AlterationsOverexpression of microRNA-155 predicts poor prognosis in glioma patients.24623016
Malignant Neoplasms, Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA-155 is highly expressed in many malignant tumors with poor prognosis, which regulates cell apoptosis, proliferation, invasion, metastasis, tumor angiogenesis, and metabolism.24623016
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-dependent regulation of transcription in non-small cell lung cancer.24625834
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese results suggest miRNA-dependent transcriptional regulation differences play an important role in determining key hallmarks of NSCLC, and may provide new biomarkers for personalized treatment strategies.24625834
AdenocarcinomaEpigenetic AlterationsNine miRNAs and 56 mRNAs were found to be differentially expressed in SCC versus adenocarcinoma samples.24625834
CGN gene, Carcinoma of lungEpigenetic AlterationsOf them, 6 miRNAs (miR-149, miR-205, miR-375, miR-378, miR-422a and miR-708) and 9 target genes (CEACAM6, CGN, CLDN3, ABCC3, MLPH, ACSL5, TMEM45B, MUC1) were validated by quantitative PCR in an independent cohort of 41 lung cancer patients.24625834
Primary malignant neoplasmEpigenetic AlterationsIn an miR-18a overexpressing cell line, the miR-18a concentration of cultured medium increased in both cell number and time-course dependent manners, suggesting microRNA might be released from cancer cells into the surrounding environment.24626859
Malignant NeoplasmsEpigenetic AlterationsRecently, circulating microRNAs have been reported to be stably detectable in plasma/serum and to function as potent non-invasive biomarkers in various cancers.24626859
Adult T-Cell Lymphoma/LeukemiaEpigenetic AlterationsOverexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells.24626955
Hematologic Neoplasms, NeoplasmsEpigenetic AlterationsMicrorna-143 (miR-143) has been suggested to be a tumor suppressor, yet its role in hematological tumors has not been determined.24626955
Coronary Artery DiseaseEpigenetic AlterationsThe plasma levels of miR-320b and miR-125b were significantly lower in patients with AMI when compared with controls, and these miRNAs may be involved in the pathogenesis of coronary heart disease.24627568
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsPeroxisome proliferator-activated receptor g-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer.24631504
CarcinogenesisEpigenetic AlterationsSince PPAR family members are able to modulate complex miRNAs networks, we hypothesized a role of miRNA-145 in the interaction between PPARg and SOX9 in colorectal carcinogenesis.24631504
Clinical CoordinatorEpigenetic AlterationsTo address this issue, we evaluated gene expression in tissue specimens of CRC patients and we took advantage of invitro models represented by CRC derived cell lines (CaCo2, SW480, HCT116, and HT-29), employing PPARg activation and/or miRNA-145 ectopic overexpression to analyze how their interplay impact the expression of SOX9 and the development of a malignant phenotype.24631504
Hollings Cancer CenterEpigenetic AlterationsTaken together, our data suggest that miR-625 might function as an antimetastatic miRNA to have an important role in HCC progression by modulating the IGF2BP1/PTEN pathway.24632613
Renal Cell CarcinomaEpigenetic AlterationsDNA methylation biomarkers predict progression-free and overall survival of metastatic renal cell cancer (mRCC) treated with antiangiogenic therapies.24633192
Primary malignant neoplasmEpigenetic AlterationsAmong some cancer patients, epigenetic changes in the nature of methylation of different gene promoter regions are observed, which affect expression of suppressor genes such as septin 9 (SEPT9).24633736
Autoimmune DiseasesEpigenetic AlterationsMiRNAs are regulatory molecules that play a key role in the immune system and are altered in many autoimmune diseases.24637658
THM geneEpigenetic AlterationsOur study suggests that different clinical phenotypes in MG share common altered mechanisms in circulating miRNAs, with no additional contribution of the thymoma.24637658
Small cell carcinoma of lungEpigenetic AlterationsA microRNA signature predicts survival in early stage small-cell lung cancer treated with surgery and adjuvant chemotherapy.24637927
Small cell carcinoma of lungEpigenetic AlterationsWe found that the miR-150/miR-886-3p signature was significantly correlated with the overall survival (OS) of SCLC patients (p = 0.02) in the training set, and both miRNA expression levels were much lower in the SCLC samples than normal lung samples.24637927
Small cell carcinoma of lungEpigenetic AlterationsFirst, we surveyed the expression of 924 miRNAs from 42 SCLC patients to discover survival-relevant miRNAs and develop prognostic models, which were then validated in an independent cohort of 40 cases using quantitative real-time PCR.24637927
Small cell carcinoma of lungEpigenetic AlterationsThese preliminary results indicated that miRNAs may serve as promising molecular prognostic markers and new therapeutic targets for SCLC.24637927
Mycosis FungoidesEpigenetic AlterationsA specific DNA methylation profile correlates with a high risk of disease progression in stage I classical (Alibert-Bazin type) mycosis fungoides.24641245
Metastatic Cervical Squamous Cell Carcinoma, Not Otherwise SpecifiedEpigenetic AlterationsCharacterization of the microRNA expression profile of cervical squamous cell carcinoma metastases.24641388
MetastasisEpigenetic AlterationsMicroRNAs (miRNAs) are important regulators of many physiological and pathological processes, including tumorigenesis and metastasis.24641388
cervical cancerEpigenetic AlterationsMiRNAs having at least 4-fold differential expression between PLN-positive and PLN-negative cervical cancer tissues were bioinformatically analyzed for target gene prediction.24641388
Reverse Transcriptase Polymerase Chain ReactionEpigenetic AlterationsSixty-nine percent of the miRNAs (27/39) had tumor-associated target genes, and the expression levels of six of those (miR-126, miR-96, miR-144, miR-657, miR-490-5p, and miR-323-3p) were confirmed by quantitative (q)RT-PCR.24641388
MetastasisEpigenetic AlterationsThese findings suggest that a panel of miRNAs may regulate multiple and various steps of the metastasis cascade by targeting metastasis-associated genes.24641388
cervical cancerEpigenetic AlterationsSince these six miRNAs are predicted to target tumor-associated genes, it is likely that they contribute to the metastatic potential of cervical cancer and may aid in prognosis or molecular therapy.24641388
Breast CarcinomaEpigenetic AlterationsMicroRNA-484 is more highly expressed in serum of early breast cancer patients compared to healthy volunteers.24641801
Breast CarcinomaEpigenetic AlterationsThese miRNAs are then assessed in serum of breast cancer patients compared to healthy volunteers.24641801
Breast CarcinomaEpigenetic AlterationsTaqman low density array (TLDA) cards were used to profile serum miRNAs in a discovery cohort of serum from 39 early breast cancer patients compared to 10 healthy volunteers.24641801
Breast CarcinomaEpigenetic AlterationsSeventeen miRNAs were found to have significantly higher levels in breast cancer serum compared to serum of healthy volunteers in the discovery cohort.24641801
ovarian neoplasmEpigenetic AlterationsOur previous laboratory and clinical data suggested that one mechanism underlying the development of platinum resistance in ovarian cancer is the acquisition of DNA methylation.24642620
Hepatitis BEpigenetic AlterationsComparison of circulating, hepatocyte specific messenger RNA and microRNA as biomarkers for chronic hepatitis B and C. Circulating microRNAs have been widely recognized as a novel category of biomarker in a variety of physiological and pathological conditions.24643113
Chronic liver diseaseEpigenetic AlterationsTaken together, our results suggest that hepatocyte specific transcripts in plasma like albumin mRNA showed greater sensitivity and specificity in differentiating HBV or HCV induced chronic liver disease than microRNA-122.24643113
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsEpigenetics are thought to play a major role in the carcinogenesis of multiple sporadic colorectal cancers (CRC).24643221
Papillary thyroid carcinoma, F9 geneEpigenetic AlterationsIt has been shown that miRNA 221, 222 and 146b are increasingly expressed while p27(Kip1) is suppressed in papillary thyroid cancer (PTC).24643689
Malignant neoplasm of thyroid, Vascular Invasion Assessment, MetastasisEpigenetic AlterationsHigher expression levels of miRNA 146b, 221 and 222 were detected in thyroid cancer patients presenting with capsule invasion, vascular invasion or lymph node metastasis, when compared to the patients lacking these features.24643689
Malignant neoplasm of thyroidEpigenetic AlterationsThe expression levels of miRNA 221, 222 and 146b were found to be increased in cases of thyroid cancer with a high risk of recurrence.24643689
Hashimoto Disease, HaitiEpigenetic AlterationsWe also measured the changes in miRNAs in the presence of Hashimotos thyroiditis (HT).24643689
HaitiEpigenetic AlterationsNo difference was found between the patients with HT and without HT regarding miRNAs expression levels.24643689
ovarian neoplasmEpigenetic AlterationsEstrogen combined with progesterone decreases cell proliferation and inhibits the expression of Bcl-2 via microRNA let-7a and miR-34b in ovarian cancer cells.24643702
NeoplasmsEpigenetic AlterationsSelective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle.24646477
Refractory Cytopenia of Childhood, Renal Cell Carcinoma PathwayEpigenetic AlterationsAlthough microRNAs (miRNA) have been revealed as crucial modulators of tumorigenesis, our understanding of their roles in renal cell carcinoma (RCC) is limited.24647573
Cell of ClaudiusEpigenetic AlterationsWe performed microarray-based miRNA profiling of clear cell RCC (ccRCC) and adjacent normal tissues and then explored the roles of miR-141 both in vitro and in vivo, which was the most significantly downregulated in ccRCC tissues.24647573
CarcinogenesisEpigenetic AlterationsHere we sought to identify human miRNAs that act as key regulators of renal carcinogenesis.24647573
palladium, Neurodegenerative Disorders, Parkinson DiseaseEpigenetic AlterationsBlood-cell-free circulating micro-RNAs (miRNAs) have been proposed as potential accessible biomarkers for neurodegenerative diseases such as Parkinsons disease (PD).24648008
Unknown (origin) (qualifier value), Parkinson DiseaseEpigenetic AlterationsIdentification of blood serum micro-RNAs associated with idiopathic and LRRK2 Parkinsons disease.24648008
Biliary strictureEpigenetic AlterationsMicroRNAs in the bile of patients with biliary strictures after liver transplantation.24648209
Diabetes Mellitus, Primary malignant neoplasmEpigenetic AlterationsRRAD (Ras-related associated with diabetes) is a small Ras-related GTPase that is frequently inactivated by DNA methylation of the CpG island in its promoter region in cancer tissues.24648519
Diabetes Mellitus, ovarian neoplasmEpigenetic AlterationsRas-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model.24648519
ovarian neoplasmEpigenetic AlterationsOur results indicate that Ras(V12)-mediated oncogenic transformation induces RRAD epigenetic inactivation, which in turn promotes glucose uptake and may contribute to ovarian cancer tumorigenesis.24648519
Glioblastoma MultiformeEpigenetic AlterationsMoreover, these epigenetic alterations overlap those described in glioblastoma patients, suggesting common mechanisms of tumorigenesis.24650279
NeoplasmsEpigenetic AlterationsEpigenetic changes are considered to be a frequent event during tumor development.24651021
Malignant neoplasm of endometrium, CarcinogenesisEpigenetic AlterationsThe finding suggests the importance of hypermethylation of this gene in endometrial carcinogenesis and could have implications for future diagnostic and therapeutic strategies for endometrial cancer based on epigenetic changes.24651021
Idiopathic Pulmonary FibrosisEpigenetic AlterationsChromatin immunoprecipitation (ChIP) and re-ChIP assays demonstrated marked increases in H3K9me3, H3K27me3, and DNA methylation, together with their respective modifying enzymes G9a, EZH2, and DNA methyltransferases (Dnmts) and respective binding proteins heterochromatin protein 1 (HP1), polycomb protein complex 1 (PRC1) and methyl CpG binding protein 2 (MeCP2), at the COX-2 promoter in lung fibroblasts from patients with IPF (F-IPFs) compared with fibroblasts from nonfibrotic lungs.24652950
Idiopathic Pulmonary FibrosisEpigenetic AlterationsOur results support a central role for G9a- and EZH2-mediated histone hypermethylation and a model of bidirectional, mutually reinforcing, and interdependent crosstalk between histone hypermethylation and DNA methylation in COX-2 epigenetic silencing in IPF.-Coward, W. R., Feghali-Bostwick, C. A., Jenkins, G., Knox, A. J., Pang, L. A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis.24652950
Idiopathic Pulmonary FibrosisEpigenetic AlterationsA central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis.24652950
Primary Neoplasm, HyperplasiaEpigenetic AlterationsAs aberrant CTCFL/BORIS expression might relate to loss of methylation, we explored methylation status in clinical samples from complex atypical hyperplasia, through primary tumors to metastatic lesions, demonstrating a pattern of DNA methylation loss during disease development and progression in line with the increase in CTCFL/BORIS mRNA expression observed.24658009
Malignant NeoplasmsEpigenetic AlterationsCancers arise through accumulating genetic and epigenetic alterations, considered relevant for phenotype and approaches to targeting new therapies.24658009
CarcinogenesisEpigenetic AlterationsIt has been demonstrated that aberrant expression of microRNAs (miRNAs) is strongly associated with carcinogenesis.24659264
NeoplasmsEpigenetic AlterationsRecently, specific miRNAs may serve as potential biomarkers for the diagnosis and prognosis of various types of tumor.24659264
Carcinoma of larynxEpigenetic AlterationsEpigenetic silencing of the TRAIL receptor by hypermethylation of a DR4 CpG island might be an underlying mechanism for TRAIL resistance in recurrent laryngeal carcinoma treated with radiation.24661673
Prostate Cancer PathwayEpigenetic AlterationsCirculating MicroRNAs in blood of patients with prostate cancer.24661838
Pancreatic carcinomaEpigenetic AlterationsA microRNA-based test improves endoscopic ultrasound-guided cytologic diagnosis of pancreatic cancer.24662333
CarcinogenesisEpigenetic AlterationsAn epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis.24662736
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsThe mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages.24663402
CarcinogenesisEpigenetic AlterationsEpigenetic events play a major role in the carcinogenesis of tobacco-related cancers.24664792
Malignant Neoplasms, Non-Small Cell Lung CarcinomaEpigenetic AlterationsAberrant microRNA (miRNA) expression is involved in tumorigenesis of several cancers, including non-small cell lung cancer (NSCLC).24665010
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHowever, less is known regarding the role of miRNA methylation in NSCLC development or clinical outcomes.24665010
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsTherefore, we tested miRNA methylation patterns by quantitative real-time methylation-specific PCR for a panel of candidate miRNAs in 19 NSCLC paired tumor and adjacent normal tissues.24665010
Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur results demonstrate that miRNA methylation plays a role in NSCLC tumorigenesis and prognosis.24665010
NeoplasmsEpigenetic AlterationsSignificant differences in methylation patterns were observed for 9 of the 12 miRNAs, all due to hypermethylation in the tumor tissue.24665010
Urinary Stress IncontinenceEpigenetic AlterationsDifferential expression of microRNAs in periurethral vaginal wall tissues of postmenopausal women with and without stress urinary incontinence.24667354
Sui ChineseEpigenetic AlterationsThe expression levels of the three miRNAs were quantified, and a reduction in SUI was revealed.24667354
SF3B1 wt Allele, Childhood Leukemia, Leukemia, Myelocytic, AcuteEpigenetic AlterationsTwo splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling.24668493
Glioblastoma Multiforme PathwayEpigenetic AlterationsTo enhance current models through discovery of novel predictive biomarkers, we employed a genome-wide, agnostic strategy to specifically capture both methylation-directed changes in gene expression and alternative associations of DNA methylation with disease survival in glioma.24670968
Primary malignant neoplasmEpigenetic AlterationsHuman GBM-associated DNA methylation, gene expression, IDH1 mutation status, and survival data were obtained from The Cancer Genome Atlas.24670968
Glioblastoma Multiforme PathwayEpigenetic AlterationsRecently, epigenetic alterations were found to play key roles in both glioma genesis and clinical outcome, demonstrating the need to integrate genetic and epigenetic data in predictive models.24670968
NeoplasmsEpigenetic AlterationsThese results support the existence of cancer-associated DNA methylation profiles in the blood of solid tumor patients that are independent of alterations in normal leukocyte distributions.24671036
melanomaEpigenetic AlterationsThe effect of histone modifications and their catalysing enzymes over euchromatic promoter DNA methylation in melanoma remains unclear.24673285
melanomaEpigenetic AlterationsEpigenetic mechanisms participate in melanoma development and progression.24673285
Stomach CarcinomaEpigenetic AlterationsDNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach.24674026
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsIn colorectal cancer, the CpG island methylator phenotype (CIMP) is defined as widespread and elevated levels of DNA methylation and CIMP+ tumors have distinctive clinicopathological and molecular features.24674026
ObesityEpigenetic AlterationsAdaptive expression of microRNA-125a in adipose tissue in response to obesity in mice and men.24675842
ObesityEpigenetic AlterationsHere, we characterized the function of microRNA-125a in adipose tissue in a context of experimentally-induced IR and obesity in mice and in obese patients.24675842
ObesityEpigenetic AlterationsOur findings indicate that microRNA-125a expression in adipose tissue adapts to IR and may play a role in the development of obesity in mice and obese subjects through uncoupled regulation of the expression of microRNA-125a and its targets.24675842
ObesityEpigenetic AlterationsMicroRNAs are emerging as new mediators in the regulation of adipose tissue biology and the development of obesity.24675842
Liver carcinomaEpigenetic AlterationsSingle nucleotide polymorphisms of microRNA processing machinery genes and outcome of hepatocellular carcinoma.24676133
Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) can affect cancer development, treatment efficacy and patients prognosis.24676133
Diabetes MellitusEpigenetic AlterationsIncreasing evidence shows that DNA methylation is involved in the development and progression of diabetes mellitus (DM) and its complications.24676352
Kidney Diseases, Diabetes MellitusEpigenetic AlterationsDNA methylation is a regulatory mechanism of CTGF expression, which is decreased in patients with DM, particularly in those with DN, and may contribute to the pathogenesis of nephropathy.24676352
Carcinoma of supraglottisEpigenetic AlterationsMicroRNA expression profiles in supraglottic carcinoma.24676647
NeoplasmsEpigenetic AlterationsUnsupervised clustering shows that miRNA profiles can distinguish tumor from normal tissues.24676647
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are single-stranded RNA molecules which regulate gene expression at the post-transcriptional level and several miRNAs have been found to be associated with some types of cancer.24676647
DICER1 protein, humanEpigenetic AlterationsDicer is a component of the MicroRNA-producing machinery.24676997
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsAberrant expression of miRNA (miR)-96 is associated with tumorigenesis and tumor progression in several solid cancers.24678958
MYOTONIC DYSTROPHY 1Epigenetic AlterationsIn conclusion, we identified a characteristic plasma miRNA signature of DM1.24679513
Myotonic DystrophyEpigenetic AlterationsPlasma microRNAs as biomarkers for myotonic dystrophy type 1.24679513
MYOTONIC DYSTROPHY 1Epigenetic AlterationsWe identified a signature of nine deregulated miRNAs in DM1 patients: eight miRNAs were increased (miR-133a, miR-193b, miR-191, miR-140-3p, miR-454, miR-574, miR-885-5p, miR-886-3p) and one (miR-27b) was decreased.24679513
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsEpigenetic processes play a key role in the central nervous system and altered levels of 5-methylcytosine have been associated with a number of neurologic phenotypes, including Alzheimers disease (AD).24679604
Malignant neoplasm of esophagusEpigenetic AlterationsMicroRNA is a class of small, well-conserved, non-coding RNAs, and could play a potential role as diagnostic and prognostic biomarkers of esophageal cancers.24680681
Malignant neoplasm of esophagusEpigenetic AlterationsWe aimed to review comprehensively the evidence of microRNA as prognostic biomarkers in esophageal cancers.24680681
Esophageal carcinomaEpigenetic AlterationsAmong 33 prognostic microRNAs identified for esophageal cancer, miR-21 and miR-375 appeared more frequently.24680681
Esophageal carcinomaEpigenetic AlterationsThese results indicated that microRNAs show promising associations with prognosis in esophageal cancer.24680681
Myeloid Leukemia, ChronicEpigenetic AlterationsThe microRNAs (miRNAs), namely miR-219-2 and miR-199b, centromeric to the ABL1 gene are frequently lost in CML patients.24680705
Adenocarcinoma of lung (disorder)Epigenetic AlterationsThese results provided a novel insight into the mechanism of miRNA regulation in lung adenocarcinoma.24682381
Carcinogenesis, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have been recognised to regulate cancer development and progression in carcinogenesis as either oncogenes or tumour suppressor genes.24682952
Chronic Lymphocytic LeukemiaEpigenetic AlterationsmicroRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia.24686393
Colorectal Cancer Pathway, AdenomaEpigenetic AlterationsIdentification of microRNA-135b in stool as a potential noninvasive biomarker for colorectal cancer and adenoma.24691020
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsDetecting microRNA (miRNA) in stool is a novel approach for colorectal cancer (CRC) screening.24691020
Clinical Coordinator, AdenomaEpigenetic AlterationsA miRNA expression array covering 667 human miRNAs was performed on five pairs of CRC and two pairs of advanced adenoma tissues.24691020
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsmicroRNAs (miRNA) are promising predictors in colorectal cancer (CRC).24691499
Arca, AdenomaEpigenetic AlterationsThe expressions of six candidate miRNAs were significantly decreased from levels in normal colorectal tissue compared with ARCA with adenoma recurrence (RACRA) in this retrospective cohort.24691499
Bladder NeoplasmEpigenetic AlterationsChanges in DNA methylation are chemically stable, occur early during tumorigenesis, and can be quantified in bladder tumors and in cells shed into the urine.24691641
Carcinoma, Transitional CellEpigenetic AlterationsWe analyzed the DNA methylation levels of six markers in 368 urine sediment samples serially collected from 90 patients with noninvasive urothelial carcinoma (Tis, Ta, T1; grade low-high).24691641
NeoplasmsEpigenetic AlterationsThe three-marker DNA methylation test reliably predicted tumor recurrence in 80% of patients superior to cytology (35%) and cystoscopy (15%) while accurately forecasting no recurrence in 74% of patients that scored negative in the test.24691641
Squamous cell carcinoma of esophagusEpigenetic AlterationsMicroRNA-203 inhibits the progression of esophageal squamous cell carcinoma with restored epithelial tissue architecture in vivo.24692008
SERPINB3 wt AlleleEpigenetic AlterationsThirteen miRNAs, including miRNA-155, were upregulated (>2-fold) in OSCC against ACF.24692283
SERPINB3 wt Allele, Primary malignant neoplasmEpigenetic AlterationsMiRNA-155 was confirmed to have significantly higher expression in OSCC against ACF (paired-samples t test; p = .041) and it was localized in the cancer nest, inflammatory area, and vascular endothelium of OSCC.24692283
SERPINB3 wt AlleleEpigenetic AlterationsHigh expression of miRNA-155 in ACF tissue was an independent prognostic indicator for OSCC survival.24692283
SERPINB3 wt Allele, Primary malignant neoplasmEpigenetic AlterationsMiRNA-155 was overexpressed in OSCC and it was located in the cancer nest, inflammatory area, and vascular endothelium of OSCC.24692283
SERPINB3 wt AlleleEpigenetic AlterationsHigh miRNA-155 expression level in ACF may predict poor prognosis in patients with OSCC.24692283
SERPINB3 wt Allele, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) play an important role in cancer, but their role in OSCC is not clarified.24692283
NeoplasmsEpigenetic AlterationsNo association between miRNA expression and tumor grade, tumor size, menopausal- or lymph node status was observed.24694649
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are present in the circulation and may be unique biomarkers for early diagnosis of human cancers.24694649
Breast CarcinomaEpigenetic AlterationsSince microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer.24694649
Breast CarcinomaEpigenetic AlterationsA signature of miRNAs was subsequently validated in an independent set of 111 serum samples from 60 patients with early-stage breast cancer and 51 healthy controls and further tested for reproducibility in 3 independent data sets from the GEO Database.24694649
Breast CarcinomaEpigenetic AlterationsA multivariable signature consisting of 9 miRNAs (miR-15a, miR-18a, miR-107, miR-133a, miR-139-5p, miR-143, miR-145, miR-365, miR-425) was identified that provided considerable discrimination between breast cancer patients and healthy controls.24694649
Breast CarcinomaEpigenetic AlterationsThe signature was also successfully validated in a previously published independent data set of circulating miRNAs in early-stage breast cancer (p = 0.024).24694649
CarcinogenesisEpigenetic AlterationsEpigenetic modifications are important early events during carcinogenesis.24695110
Diffuse Large B-Cell LymphomaEpigenetic AlterationsTo conclude, our findings demonstrated that epigenetic dysregulation of TFPI-2, leading to its reduced expression, is frequently detected in canine DLBCL.24695110
ovarian neoplasmEpigenetic AlterationsMicroRNA-25 expression level is an independent prognostic factor in epithelial ovarian cancer.24696291
Squamous cell carcinoma of esophagusEpigenetic AlterationsDifferent expression of miRNAs in early esophageal squamous cell carcinoma with differential prognosis.24697845
MetastasisEpigenetic AlterationsSuch miRNAs were associated with lympho-vascular invasion and metastasis, and acted as predictive markers of lympho-vascular invasion and metastasis.24697845
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe detection of these miRNAs forms an important basis for the treatment of early ESCC.24697845
Virus DiseasesEpigenetic AlterationsOur findings unravel the significant alterations in serum miRNA expression following virus infection and manifest great potential of circulating miRNAs for the diagnosis of viral diseases.24699363
Communicable DiseasesEpigenetic AlterationsUpon infection, a total of 395 miRNAs were expressed in the serum pool of patients, far beyond the 221 in healthy controls.24699363
Stomach CarcinomaEpigenetic AlterationsClinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer.24700496
Carcinoma in situ of skinEpigenetic AlterationsEpigenetic alterations in metastatic cutaneous carcinoma.24700717
Primary malignant neoplasmEpigenetic AlterationsEpigenetic profiles of 37 primary cases of cutaneous SCC and BCC were quantified via the Illumina Goldengate Cancer Panel.24700717
Skin carcinomaEpigenetic AlterationsEpigenetic profiling may prove useful in future diagnosis and prevention of advanced nonmelanoma skin cancers.24700717
Primary malignant neoplasmEpigenetic AlterationsMicro-RNAs (miRNAs) are small noncoding RNAs that play a crucial role in regulating gene expression and are involved in various biological processes, including cancer development.24703100
Malignant neoplasm of kidneyEpigenetic AlterationsIn summary, we describe the miRNA expression profile of a relatively infrequent type of renal cancer.24703100
Clear cell papillary renal cell carcinoma, Conventional (Clear Cell) Renal Cell Carcinoma, Papillary Renal Cell CarcinomaEpigenetic AlterationsClear cell papillary renal cell carcinoma: micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma.24703100
Aggressive behaviorEpigenetic AlterationsMoreover, CCPRCC lacks dysregulation of important miRNAs typically associated with aggressive behavior.24703100
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNA let-7a-3 gene methylation is associated with karyotyping, CEBPA promoter methylation, and survival in acute myeloid leukemia.24703161
Primary malignant neoplasmEpigenetic AlterationsLet-7a-3 transcribes the miRNA let-7a, of which the expression is dysregulated in cancer.24703161
Hollings Cancer CenterEpigenetic AlterationsIn summary, our results suggest that DNA methylation may be involved in the inactivation of miR-34b in HCC.24704024
Liver carcinomaEpigenetic AlterationsMethylation-associated silencing of microRNA-34b in hepatocellular carcinoma cancer.24704024
Malignant Neoplasms, Hollings Cancer CenterEpigenetic AlterationsMicroRNAs (miRNAs) can act as oncogenes or tumor-suppressor genes in human cancers including HCC.24704024
Clinical CoordinatorEpigenetic AlterationsExosomal miRNA signatures appear to mirror pathological changes of CRC patients and several miRNAs are promising biomarkers for non-invasive diagnosis of the disease.24705249
Malignant tumor of colonEpigenetic AlterationsCirculating exosomal microRNAs as biomarkers of colon cancer.24705249
Primary malignant neoplasmEpigenetic AlterationsExosomal microRNAs (miRNAs) have been attracting major interest as potential diagnostic biomarkers of cancer.24705249
Malignant tumor of colonEpigenetic AlterationsThe expression levels of miRNAs in the culture medium of five colon cancer cell lines were also compared with those in the culture medium of a normal colon-derived cell line.24705249
Neoplasms, disease stageEpigenetic AlterationsThe serum exosomal levels of seven miRNAs (let-7a, miR-1229, miR-1246, miR-150, miR-21, miR-223, and miR-23a) were significantly higher in primary CRC patients, even those with early stage disease, than in healthy controls, and were significantly down-regulated after surgical resection of tumors.24705249
Malignant tumor of colonEpigenetic AlterationsThese miRNAs were also secreted at significantly higher levels by colon cancer cell lines than by a normal colon-derived cell line.24705249
Prostate Cancer PathwayEpigenetic AlterationsThis highlights the need for independent validation patient cohorts and suggests that urinary microRNA signatures at radical prostatectomy may not be a robust way to predict the course of clinical disease after definitive treatment for prostate cancer.24705338
Prostate Cancer PathwayEpigenetic AlterationsCurated microRNAs in urine and blood fail to validate as predictive biomarkers for high-risk prostate cancer.24705338
Prostate Cancer PathwayEpigenetic AlterationsOur initial findings suggested that plasma and urinary profiling of microRNAs at radical prostatectomy may allow prognostication of prostate cancer behaviour.24705338
Squamous cell carcinoma of esophagusEpigenetic AlterationsLong non-coding RNA 91H contributes to the occurrence and progression of esophageal squamous cell carcinoma by inhibiting IGF2 expression.24706416
Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsHypermethylation of DNA is an epigenetic alteration commonly found in colorectal cancer (CRC) and can also be detected in blood samples of cancer patients.24708595
Ischemic strokeEpigenetic AlterationsThe relationship between circulating microRNA-223 and pathogenesis of acute ischemic stroke is unknown.24708646
Infarction, TOAST ClassificationEpigenetic AlterationsThe relationship between the microRNA-223 level and NIHSS scores, TOAST subtypes, and infarct volume was analyzed respectively.24708646
Ischemic strokeEpigenetic AlterationsmicroRNA-223 levels in the circulating blood of acute ischemic stroke patients were greatly increased compared to the control (p < 0.05).24708646
Cerebrovascular accident, InfarctionEpigenetic AlterationsmicroRNA-223, which were negatively correlated with NIHSS scores (r = -0.531, p < 0.01) and infarct volume (r = -0.265, p = 0.039), was significantly up-regulated in large artery and small artery strokes.24708646
Cerebral artery occlusionEpigenetic AlterationsMoreover, microRNA-223 in blood and brain were positively correlated (r = 0.834, p < 0.05), and they were up-regulated significantly in mice that underwent middle cerebral artery occlusion (p < 0.05).24708646
Cerebrovascular accident, Ischemic strokeEpigenetic AlterationsOur results suggest that microRNA-223 is associated with acute ischemic stroke and possibly plays a role in stroke through up-regulating growth factor such as insulin-like growth factor-1 gene.24708646
Arthritis, GoutyEpigenetic AlterationsMicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis.24708712
DiseaseEpigenetic AlterationsTheir data, collected from June 22, 2011 to September 28, 2012, in a comprehensive epidemiological survey and during medical examinations, permitted an extensive evaluation of the relation between metal exposure, gene, epigenetics and risk of human diseases.24709102
Colorectal Cancer PathwayEpigenetic AlterationsIdentification of a circulating microRNA signature for colorectal cancer detection.24709885
Clinical CoordinatorEpigenetic AlterationsWe built a serum microRNA expression profile signature and tested its specificity and sensitivity as a biomarker in the diagnosis of CRC.24709885
Clinical CoordinatorEpigenetic AlterationsThus, the identified six-miRNA signature can be used as a noninvasive biomarker for the diagnosis of CRC, with relatively high sensitivity and specificity.24709885
NeoplasmsEpigenetic AlterationsThe discovery of microRNAs (miRNAs) and their different expression profiles among different kinds of diseases has opened a new avenue for tumor diagnosis.24709885
Clinical CoordinatorEpigenetic AlterationsWe conducted a two phase case-control test to identify serum miRNAs as biomarkers for CRC diagnosis.24709885
Clinical CoordinatorEpigenetic AlterationsThe expression levels of the six serum miRNAs were also correlated with CRC progression.24709885
Malignant Head and Neck NeoplasmEpigenetic AlterationsFrequency of genetic and epigenetic alterations of p14ARF and p16INK4A in head and neck cancer in a Hungarian population.24710824
cervical cancerEpigenetic AlterationsMicroRNA-215 is a potential prognostic marker for cervical cancer.24710934
Malignant Neoplasms, Metastasis, NeoplasmsEpigenetic AlterationsRecently, microRNAs (miRNAs) have been shown to be involved in multiple biological pathways that can influence tumor progression and metastasis and they can serve as prognostic biomarkers in many cancers.24710934
Hormone refractory prostate cancerEpigenetic AlterationsCirculating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer.24714754
Prostate Cancer Pathway, Aggressive behaviorEpigenetic AlterationsDNA promoter hypermethylation is a frequent epigenetic event in prostate cancer, but few studies of DNA methylation in relation to features of more aggressive tumors or prostate cancer recurrence have been completed.24718283
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsWe used the Infinium HumanMethylation450 BeadChip to assess DNA methylation in tumor tissue from 407 patients with clinically localized prostate cancer who underwent radical prostatectomy.24718283
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsTumor DNA methylation profiling may help to distinguish patients with prostate cancer at higher risk for disease recurrence.24718283
Metastasis, NeoplasmsEpigenetic AlterationsAberrant DNA methylation and histone H3-K9 trimethylation of EFEMP1 may be responsible for its downregulation in GC, and thus have an important role in tumor invasion and metastasis.24718752
palladium, Parkinson DiseaseEpigenetic AlterationsDNA methylation of a CpG island located in intron 1 of the a-synuclein gene (SNCA) has been reported to play an essential role in the regulation of a-synuclein transcription, and probably has a close association with Parkinsons disease (PD).24721670
palladiumEpigenetic AlterationsOur results indicated that there were no significant differences in DNA methylation between PD patients and controls.24721670
Diffuse Large B-Cell LymphomaEpigenetic AlterationsThus, the TP53/MIR34A "double hit" characterizes a very aggressive subgroup of DLBCL, which may be treatable with epigenetic therapy prior to or in combination with conventional immunochemotherapy.24722400
NeoplasmsEpigenetic AlterationsAccumulating evidence is revealing an important role of microRNA (miRNA) in tumor progression and chemotherapeutic resistance.24723223
DICER1 protein, humanEpigenetic AlterationsDicer is a cytoplasmic endoribonuclease type III crucial for production of mature miRNAs.24723223
Lichen diseaseEpigenetic AlterationsGlobal DNA methylation: uncommon event in oral lichenoid disease.24724918
Squamous cell carcinoma, CarcinogenesisEpigenetic AlterationsAccumulating evidence indicates that aberrant DNA methylation is closely related to oral carcinogenesis, and it has been shown that methylation changes might be used as prognostic biomarker in oral squamous cell carcinoma.24724918
Malignant tumor of colonEpigenetic AlterationsAssociation study of the let-7 miRNA-complementary site variant in the 3 untranslated region of the KRAS gene in stage III colon cancer (NCCTG N0147 Clinical Trial).24727325
Angina, UnstableEpigenetic AlterationsAssessment of microRNAs in patients with unstable angina pectoris.24727883
Glioma, NeoplasmsEpigenetic AlterationsDifferential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours.24729345
Hypoxia, NeoplasmsEpigenetic AlterationsThe microRNA, miR-210, is frequently associated with hypoxia induction, and an increase in its levels is often correlated with poor prognosis in many solid tumours.24729345
Malignant neoplasm of endometriumEpigenetic AlterationsThe KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905.24732316
NeoplasmsEpigenetic AlterationsIn conclusion, the frequent heterozygous losses of the RB1 locus could partly explain the decreased RB expression in MCV-negative MCC tumors, although the effects of RB1 mutations, coinciding promoter hypermethylation and, for example, miRNA regulation, cannot be excluded.24735260
NeoplasmsEpigenetic AlterationsExpression of CYP24A1 was inversely correlated with promoter DNA methylation in lung AC cell lines and tumors.24736069
Adenocarcinoma of lung (disorder)Epigenetic AlterationsEpigenetic regulation of vitamin D metabolism in human lung adenocarcinoma.24736069
CarcinogenesisEpigenetic AlterationsDNA methylation status of a distinctively different subset of genes is associated with each histologic Lauren classification subtype in early gastric carcinogenesis.24737029
CarcinogenesisEpigenetic AlterationsDNA methylation change is known to play a crucial role in early gastric carcinogenesis.24737029
Stomach CarcinomaEpigenetic AlterationsAberrant histone methylation and the effect of Suv39H1 siRNA on gastric carcinoma.24737085
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsWe developed cMethDNA, a quantitative multiplexed methylation-specific PCR assay for a panel of ten genes, consisting of novel and known breast cancer hypermethylated markers identified by mining our previously reported study of DNA methylation patterns in breast tissue (103 cancer, 21 normal on the Illumina HumanMethylation27 Beadchip) and then validating the 10-gene panel in The Cancer Genome Atlas project breast cancer methylome database.24737128
Metastasis, Primary malignant neoplasmEpigenetic AlterationsAccumulating evidence indicates that dysregulated microRNAs (miRNAs) are involved in cancer development, progression and metastasis.24737193
Malignant tumor of colonEpigenetic AlterationsExpression levels of SELENBP1, carcinoembryonic antigen (CEA) and alkaline phosphatase (AKP) were determined in cultures of human colon cancer cell lines (SW480, SW620 and HT29) folllowing treatment with i) sodium butyrate (NaB, 2 mM), a differentiation inducer; ii) Trichostatin A (TSA, 0.3 uM), a histone deacetylase inhibitor; or iii) 5-aza-2-deoxycytidine (5-Aza-dC, 5 uM), a DNA methylation inhibitor.24737289
Colorectal Cancer PathwayEpigenetic AlterationsSelenium-binding protein 1 is associated with the degree of colorectal cancer differentiation and is regulated by histone modification.24737289
Stomach CarcinomaEpigenetic AlterationsAberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer.24737431
Prostate Cancer PathwayEpigenetic AlterationsThe GABRE~miR-452~miR-224 locus is downregulated and hypermethylated in prostate cancer and is a new promising epigenetic candidate biomarker for prostate cancer diagnosis and prognosis.24737792
Prostate Cancer PathwayEpigenetic AlterationsTumor-suppressive functions of the intronic miR-224 and miR-452 were demonstrated in two prostate cancer cell lines, suggesting that epigenetic silencing of GABRE~miR-452~miR-224 may be selected for in prostate cancer.24737792
Dermatitis, AtopicEpigenetic AlterationsAn integrated epigenetic and transcriptomic analysis reveals distinct tissue-specific patterns of DNA methylation associated with atopic dermatitis.24739813
Admitting diagnosisEpigenetic AlterationsNo genome-wide significant DNA methylation differences between AD cases and controls were observed in whole blood, T cells, and B cells, and, in general, intra-individual differences in DNA methylation were larger than interindividual differences.24739813
Admitting diagnosisEpigenetic AlterationsOur pilot study provides preliminary evidence for functionally relevant DNA methylation differences associated with AD, particularly in the epidermis, and represents a starting point for future investigations of epigenetic mechanisms in AD.24739813
Prostate Cancer PathwayEpigenetic AlterationsRecent evidence indicates that microRNAs might participate in prostate cancer initiation, progression and treatment response.24740842
Prostate Cancer PathwayEpigenetic AlterationsGermline variations in microRNAs might alter target gene expression and modify the efficacy of prostate cancer therapy.24740842
palladiumEpigenetic AlterationsIncreased expression of alpha-synuclein (PARK4) is a disease-triggering event in familial PD and also observed in SN DA neurons in sporadic PD but related transcriptional changes are unknown.24742361
Clinical Coordinator, NeoplasmsEpigenetic AlterationsTo this end, we performed a miRNA profiling of 1547 distinct human miRNAs using 31 samples of tumor and paired normal mucosa obtained from 31 CRC patients.24743265
Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsAberrant expression of microRNAs (miRNAs) has been implicated in human cancer, including colorectal cancer (CRC).24743265
Clinical CoordinatorEpigenetic AlterationsHowever, the nature of an association between these miRNAs and clinical stages of CRC is still not clear.24743265
Colorectal CarcinomaEpigenetic AlterationsAmong the 569 dysregulated miRNAs, downregulation of 17 was associated with stages II, III, and IV colon and rectal cancers (separate or combined), according to our criteria.24743265
Clinical Coordinator, MetastasisEpigenetic AlterationsWe also assessed the potential of these dysregulated miRNAs as diagnostic biomarkers for CRC patients who were without metastasis, and the value of the dysregulated miRNAs for predicting metastasis, lymph node and distant.24743265
Chronic Obstructive Airway Disease, Adenocarcinoma of lung (disorder)Epigenetic AlterationsMicroRNA clusters: dysregulation in lung adenocarcinoma and COPD.24743967
Chronic Obstructive Airway Disease, AdenocarcinomaEpigenetic AlterationsExpression of 381 miRNAs was quantified by TaqMan Human MicroRNA A Array v2.0 in bronchoalveolar lavage fluid samples from 87 patients classified into four groups: COPD, adenocarcinoma, adenocarcinoma with COPD, and control (neither COPD nor adenocarcinoma).24743967
Chronic Obstructive Airway Disease, AdenocarcinomaEpigenetic AlterationsFour miRNA clusters (the mir-17-92 cluster and its paralogues, mir-106a-363 and mir-106b-25; and the miR-192-194 cluster) were upregulated in patients with adenocarcinoma and one miRNA cluster (miR-132-212) was upregulated in patients with COPD.24743967
Chronic Obstructive Airway Disease, AdenocarcinomaEpigenetic AlterationsThese results contribute to unravelling miRNA-controlled networks involved in the pathogenesis of adenocarcinoma and COPD, and provide new tools of potential use as biomarkers for diagnosis and/or therapeutic purposes.24743967
Coronary Artery DiseaseEpigenetic AlterationsAssociation of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary artery disease patients.24745016
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are closely involved in the development and progression of various tumors.24745613
Intrahepatic CholangiocarcinomaEpigenetic AlterationsIMP3 expression is associated with poor outcome and epigenetic deregulation in intrahepatic cholangiocarcinoma.24745619
Breast Cancer CellEpigenetic AlterationsTo our knoweldge, this is the first direct evidence of epigenetic deregulation of IMP3 in human cancer.24745619
Myometrial Invasion, Endometrial Endometrioid Adenocarcinoma, Primary malignant neoplasmEpigenetic AlterationsMicro-RNA (miRNA) signatures influence the prognosis of cancer, but little is known about their role in myometrial invasion in endometrioid endometrial adenocarcinoma (EEC).24746199
Adenocarcinoma in Situ, AdenocarcinomaEpigenetic AlterationsOf the 20 miRNAs differentially expressed in noninvasive (stage IA) and myoinvasive adenocarcinomas (stage IB and IC), miR27 was overexpressed in invasive adenocarcinomas, and its expression increased linearly according to stage.24746199
cervical cancerEpigenetic AlterationsOverexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer.24748337
Malignant NeoplasmsEpigenetic AlterationsThe long noncoding RNA HOTAIR has been reported to be a good biomarker for poor prognosis in a variety of human cancers.24748337
Stomach CarcinomaEpigenetic AlterationsThis study explores the possibility of methylation of DNA damage repair genes serving as a prognostic and chemo-sensitive marker in human gastric cancer.24748501
Clinical CoordinatorEpigenetic AlterationsWe provide the first evidence that variations in potential miRNA target-binding sites in the 3UTR of MMR genes may contribute to modulate CRC prognosis and predictivity of therapy.24755277
Secondary malignant neoplasm of liver, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1.24755295
Secondary malignant neoplasm of liver, Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer tissues from patients with or without liver metastases were profiled to identify differentially expressed microRNA.24755295
NeoplasmsEpigenetic AlterationsThus, genetic alterations of b-catenin and epigenetics-related Wif-1 promoter hypermethylation may be important mechanisms underlying AC tumor formation though aberrant canonical Wnt/b-catenin signaling activation.24755523
Tumors of Adrenal CortexEpigenetic AlterationsExtracellular activation of Wnt signaling through epigenetic dysregulation of Wnt inhibitory factor-1 (Wif-1) is associated with pathogenesis of adrenocortical tumor.24755523
NeoplasmsEpigenetic AlterationsWe investigated epigenetic regulation of Wif-1 and its association with adrenocortical (AC) tumor pathogenesis in light of Wnt activation.24755523
NeoplasmsEpigenetic AlterationsDysregulation of microRNAs (miRNAs) expression is an important step in tumor progression as miRNAs can act as tumor suppressors or oncogenes and may affect cell sensitivity to chemotherapy.24755707
Leukemia, Myelocytic, AcuteEpigenetic AlterationsA detailed understanding of the mechanisms of microRNA that are clinically relevant in AML may enhance our ability to predict and overcome drug resistance.24756163
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNAs have been shown to play an important role in regulating the chemotherapy resistance in AML.24756163
Breast CarcinomaEpigenetic AlterationsAberrant DNA methylation of integrin a4 in human breast cancer.24756760
Ductal CarcinomaEpigenetic AlterationsIn addition, DNA methylation of integrin a4 showed statistical correlation with HER2 positivity and higher histologic grade (p = 0.001, 0.008 in ductal carcinoma in situ and 0.003 in invasive ductal carcinoma).24756760
Breast CarcinomaEpigenetic AlterationsMoreover, we found that the downregulated expression of integrin a4 in a heavily methylated breast cancer cell line (ZR-75) was restored by treatment with 5-aza-2deoxycytidine, a DNA methyltransferase inhibitor, implying transcriptional silencing by DNA methylation.24756760
Breast CarcinomaEpigenetic AlterationsDNA methylation of integrin a4 may be a poor prognostic factor which affects undifferentiated histologic change of breast cancer.24756760
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsThese results suggest that these three variants in the miRNA binding sites of TYMS may be associated with cancer risk and survival of gastric cancer patients.24756984
Degenerative polyarthritisEpigenetic AlterationsLong noncoding RNAs (lncRNAs) play crucial regulatory roles in diverse biologic processes, but knowledge of lncRNAs in osteoarthritis (OA) is limited.24757148
Lupus Erythematosus, SystemicEpigenetic AlterationsOur group recently identified specific histone modifications occurring during apoptosis that play an important role in the autoimmune response in SLE.24758196
Lupus Erythematosus, SystemicEpigenetic AlterationsThis implies that specific histone modifications, in particular acetylation, might enhance the immunostimulatory potential of NETs in SLE.24758196
Hepatocellular carcinoma, scirrhousEpigenetic AlterationsCorrelation of microRNA-16, microRNA-21 and microRNA-101 expression with cyclooxygenase-2 expression and angiogenic factors in cirrhotic and noncirrhotic human hepatocellular carcinoma.24759835
Hormone refractory prostate cancerEpigenetic AlterationsOur purpose was to identify a miRNA expression profile associated with the development of CRPC.24760272
Aggressive behavior, Primary malignant neoplasmEpigenetic AlterationsThe increased evidence that miRNAs are involved in cancer development and progression has made them potential biomarkers for cancer diagnosis, prognosis, and aggressiveness.24760272
ChordomaEpigenetic AlterationsMicroRNA-1 (miR-1) inhibits chordoma cell migration and invasion by targeting slug.24760686
cervical cancerEpigenetic AlterationsEpigenetic regulation of human riboflavin transporter 2(hRFT2) in cervical cancers from Uighur women.24761851
CarcinogenesisEpigenetic AlterationsOur results suggested that epigenetic modifications are responsible for aberrant expression of the hRFT2 gene, and may help to understand mechanisms of cervical carcinogenesis.24761851
ovarian neoplasmEpigenetic AlterationsDNA was extracted from 200 formalin-fixed paraffin-embedded ovarian cancer and their normal adjacent tissues (NAT) and DNA methylation was detected by methylation specific PCR (MSP).24761891
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsThis finding highlights the possible role of the high risk HPV virus in ovarian carcinogenesis or in facilitating cancer progression by suppression of SFRP and APC genes via DNA methylation.24761891
melanomaEpigenetic AlterationsWe observed that CDKN2A epimutation is rare in melanoma families, and therefore is unlikely to cause major susceptibility in families without CDKN2A mutations.24762620
Stomach CarcinomaEpigenetic AlterationsMicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain.24763054
PathologyEpigenetic AlterationsComparing the top miRNAs with the highest levels detected in each pool, we found close homology only between the BAL samples of the two pathologies.24764226
NeoplasmsEpigenetic AlterationsIn tumor plasma, we found a higher percentage of miRNAs with increased levels than in tumor BAL or in nontumor plasma.24764226
AdenomaEpigenetic AlterationsBRBs significantly decreased cellular proliferation, DNA methylation methyl transferase 1 protein expression, and p16 promoter methylation, but not promoter methylation of the Wnt pathway antagonists, SFRP2 and WIF1, in rectal polyps (adenomas) from responders but not from nonresponders.24764585
Prostate Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsTumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer.24768995
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur recent study of the microRNA expression signature of prostate cancer (PCa) revealed that microRNA-224 (miR-224) is significantly downregulated in PCa tissues.24768995
Malignant NeoplasmsEpigenetic AlterationsThe single nucleotide polymorphisms (SNPs) involved in microRNA (miRNA) functions are potential biomarkers for prognosis of various human cancers.24770678
levamisoleEpigenetic AlterationsInitially, 10 high-grade LMS and 10 high-grade UPS were profiled with a miRNA microarray.24771630
levamisole, NeoplasmsEpigenetic AlterationsWe identified miRNA expression patterns in LMS and UPS, linking them to chromosomal regions and mRNA targets known to be involved in tumor development/progression of LMS and UPS.24771630
Colorectal Cancer PathwayEpigenetic AlterationsTo identify microRNAs (miRNA) that predict response to anti-EGFR antibodies in patients with wild-type KRAS metastatic colorectal cancer (mCRC).24771647
Islet Cell TumorEpigenetic AlterationsGlobal microRNA profiling of pancreatic neuroendocrine neoplasias.24778027
Colorectal Cancer Pathway, Adenocarcinoma of lung (disorder)Epigenetic AlterationsFurthermore, microRNA profiles of primary colorectal cancer in our database indicated that these two microRNAs were overexpressed in primary colorectal cancer relative to primary lung adenocarcinomas.24778034
Carcinoma of lung, Secondary malignant neoplasm of rectum, Adenocarcinoma of lung (disorder)Epigenetic AlterationsMicroRNA profiles predict the histology of primary lung carcinomas, and differentiate between primary lung adenocarcinomas and colorectal cancer metastases.24778034
Malignant neoplasm of endometrium, NeoplasmsEpigenetic AlterationsmicroRNA 31 functions as an endometrial cancer oncogene by suppressing Hippo tumor suppressor pathway.24779718
Breast CarcinomaEpigenetic AlterationsMicroRNAs play essential role in breast carcinoma progression and invasion.24781337
Pituitary macroadenoma, NeoplasmsEpigenetic AlterationsA pilot genome-scale profiling of DNA methylation in sporadic pituitary macroadenomas: association with tumor invasion and histopathological subtype.24781529
Oropharyngeal Carcinoma, NeoplasmsEpigenetic AlterationsPrognostic factors in oral and oropharyngeal cancer based on ultrastructural analysis and DNA methylation of the tumor and surgical margin.24782031
OsteosarcomaEpigenetic AlterationsPrognostic value of microRNA-223/epithelial cell transforming sequence 2 signaling in patients with osteosarcoma.24784921
OsteosarcomaEpigenetic AlterationsMicroRNA-223 (miR-223) has been demonstrated to be implicated in cell proliferation and cell cycle progression of osteosarcoma cell lines by regulating its target gene epithelial cell transforming sequence 2 (ECT2).24784921
Primary malignant neoplasmEpigenetic AlterationsAltered expression of microRNA (miRNA) can significantly contribute to cancer development and recent studies have shown that a number of miRNAs may be regulated by DNA methylation.24785261
Stomach Carcinoma, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsOur study provides unequivocal evidence that MIR941 and MIR1247 are transcriptionally regulated by DNA methylation in gastric cancer and that they have tumor suppressor properties through their inhibition of key cancer promoting genes in this context.24785261
Malignant neoplasm of stomachEpigenetic AlterationsWe confirmed that these miRNAs are also densely methylated in primary gastric cancers but not in normal gastric tissues.24785261
Stomach CarcinomaEpigenetic AlterationsIn addition, we demonstrated that ectopic expression of these two miRNAs in AGS gastric cancer cells resulted in suppression of growth and migration.24785261
SpondylitisEpigenetic AlterationsHigher expression of whole blood microRNA-21 in patients with ankylosing spondylitis associated with programmed cell death 4 mRNA expression and collagen cross-linked C-telopeptide concentration.24786924
Cessation of lifeEpigenetic AlterationsThe binding of microRNA-21 (miR-21) to programmed cell death 4 (PDCD4) could inhibit the expression of PDCD4 and further induce the activation of osteoclasts.24786924
Ischemic strokeEpigenetic AlterationsGlobal DNA methylation of ischemic stroke subtypes.24788121
Cerebrovascular accident, Pathology, Cardiovascular DiseasesEpigenetic AlterationsEpigenetic mechanisms, such as DNA methylation, change over time and may be associated with aging processes and with modulation of the risk of various pathologies, such as cardiovascular disease and stroke.24788121
AdenomaEpigenetic AlterationsDifferential expression of microRNA-320a, -145, and -192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum.24791633
Carcinogenesis, MetastasisEpigenetic AlterationsMicroRNA (miR)-320a, miR-145, and miR-192 have been shown to play a role in colorectal carcinogenesis and metastasis.24791633
Colonic adenomasEpigenetic AlterationsGenome-wide miRNA expression profiling was performed on 113 colon adenomas.24791633
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLong non-coding RNA MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion.24793017
Malignant NeoplasmsEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have emerged as major players in governing fundamental biological processes, and many of which are misregulated in multiple cancers and likely to play a functional role in tumorigenesis.24793017
Colorectal Cancer Pathway, AdenomaEpigenetic AlterationsDifferences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer.24793120
Malignant NeoplasmsEpigenetic AlterationsWe found genome-wide alterations in DNA methylation in the nontumor colon mucosa and cancers.24793120
Malignant Neoplasms, AdenomaEpigenetic AlterationsThree classes of cancers and 2 classes of adenomas were identified based on their DNA methylation patterns.24793120
Malignant Neoplasms, Colonic Neoplasms, AdenomaEpigenetic AlterationsAdditionally, the high-frequency methylation adenoma class had DNA methylation signatures similar to those of cancers with low or intermediate levels of methylation, and the low-frequency methylation adenoma class had methylation signatures similar to that of nontumor colon tissue.24793120
Tubular adenoma, Primary malignant neoplasmEpigenetic AlterationsGenome-wide alterations in DNA methylation occur during early stages of progression of tubular adenomas to cancer.24793120
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsGenetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC).24793120
Clinical Coordinator, Tubular adenomaEpigenetic AlterationsAlthough epigenetic and genetic alterations have been detected in conventional tubular adenomas, little is known about how these affect progression to CRC.24793120
Colorectal Carcinoma, Tubular adenoma, Primary malignant neoplasmEpigenetic AlterationsWe compared methylomes of normal colon mucosa, tubular adenomas, and colorectal cancers to determine how epigenetic alterations might contribute to cancer formation.24793120
NeoplasmsEpigenetic AlterationsIn ccRCC, microRNAs (miRs) differentially expressed in tumour tissue have been identified and have been proposed to predict prognosis.24793999
Breast Carcinoma, DiscordanceEpigenetic AlterationsThe discordance of ER expression status in primary and relapse/metastatic lesions of breast cancer might be related to DNA methylation status.24796462
Carcinoma, Squamous cell carcinoma of esophagusEpigenetic AlterationsF-box protein 32 (FBXO32) (also known as atrogin-1), a member of the F-box protein family, has recently been identified as a transforming growth factor beta (TGF-b)/Smad target gene involved in regulating cell survival, and it may be transcriptionally silenced by epigenetic mechanisms in some kinds of carcinomas, yet its role in esophageal squamous cell carcinoma (ESCC) has not been defined.24798237
Colorectal NeoplasmsEpigenetic AlterationsCAHM, a long non-coding RNA gene hypermethylated in colorectal neoplasia.24799664
Secondary malignant neoplasm of lung, Malignant neoplasm of liver, Primary malignant neoplasmEpigenetic AlterationsEfficacy and potential microRNA mechanism for computed tomography-guided percutaneous radiofrequency ablation of primary lung cancer and lung metastasis from liver cancer.24802132
Carcinoma of lungEpigenetic AlterationsReal-time RT-PCR was used to quantify the selected miRNAs known to be play key roles in lung cancer.24802132
Hollings Cancer Center, Neoplasms, Neoplasm MetastasisEpigenetic AlterationsCT-PRFA is a effective treatment for primary NSCLCs and secondary lung tumors from HCC and the efficacy may be related to its ability to normalize deregulated expression of miRNAs: upregulating tumor suppressor miRNAs and downregulating oncomiRs.24802132
Stomach CarcinomaEpigenetic AlterationsFinally, we show that JMJD2A level is correlated with the level of the pro-apoptotic microRNA miR-34a in gastric cancer tissues and JMJD2A represses the expression of miR-34a by decreasing its promoter activity.24802408
Refractory Cytopenia of Childhood, Renal Cell Carcinoma PathwayEpigenetic AlterationsDownregulation of miRNA expression has been identified as a novel feature of renal cell carcinoma (RCC).24802708
NeoplasmsEpigenetic AlterationsOur findings indicate that the miR-200 family of microRNAs, and miR-429 in particular, play a critical role in the functioning of OC metastasizing cells and that targeted delivery of miR-429, and perhaps other miR-200 family members, in combination with platinum-based chemotherapies may be an effective strategy in reducing OC metastasis and tumor recurrence.24802724
Hollings Cancer CenterEpigenetic AlterationsFourteen frequently deregulated miRNAs in HCC (miR-17-5p, miR-18a, miR-21, miR-34a, miR-122, miR-195, miR-210, miR-214, miR-221, miR-222, miR-223, miR-224, miR-140, miR-328) were tested by qRT-PCR.24804874
Neoplasm MetastasisEpigenetic AlterationsArgonaute 2 (AGO2) is the core effector protein of the miRNA-induced silencing complex and overexpression of AGO2 might enhance tumor metastasis.24805183
Neoplasm MetastasisEpigenetic AlterationsEvidence in literature has demonstrated that some microRNAs (miRNAs) play a pivotal role in most solid tumor metastasis.24805183
Stomach CarcinomaEpigenetic AlterationsDysregulated miRNAs in gastric cancer are usually screened by miRNA microarray from clinical samples, however, reports have indicated that results of each miRNA microarray screening are considerably different, and dysregulated miRNAs, especially downregulated miRNAs were contradictory.24805774
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsThe Human Cancer Pathway Finder miRNA PCR array could be used to screen dysregulated miRNAs effectively, and 4 screened miRNAs, mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p were found to be downregulated in gastric cancer.24805774
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsClinical significance and bioinformatic analysis on the target genes of these 4 miRNAs indicated that they were deeply involved in tumorigenesis, suggesting roles such as miRNA tumor suppressors in gastric cancer tumorigenesis which could be applied in gastric cancer diagnosis and prognosis.24805774
Stomach CarcinomaEpigenetic AlterationsThirty-eight miRNAs were upregulated, and four miRNAs were downregulated in gastric cancer cell lines.24805774
Lymphatic Invasion Assessment, Stomach Carcinoma, Venous Invasion, MetastasisEpigenetic AlterationsClinical significance of 4 miRNAs including mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tissue compared with adjacent non-tumor tissues of 58 patients indicated that the low-expression group of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p showed more extensive lymph node metastasis, lymphatic invasion, venous invasion, high-stage Borrmann type, lymphatic invasion and poor differentiation than that of the high-expression groups, respectively (P<0.05; kh2 test).24805774
Primary malignant neoplasmEpigenetic AlterationsEnriched GO terms showed that targeted genes of the 4 miRNAs concentrated on 339 terms, 24 of 339 terms are associated with cancer tumorigenesis.24805774
MIR152 geneEpigenetic AlterationsThe results obtained by miRNA microarrays of differential expression with hsa-miR-106b-3p, hsa-miR-152, hsa-miR-200a-3p, hsa-miR-381, and hsa-miR-429 were confirmed by real-time PCR.24805828
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer.24805877
Liver carcinomaEpigenetic AlterationsMicroRNA-148b expression is decreased in hepatocellular carcinoma and associated with prognosis.24805877
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-148a (miR-148a) has recently been found to be involved in many critical processes in human malignancies.24805877
Liver carcinomaEpigenetic AlterationsEpigenetic high regulation of ATAD2 regulates the Hh pathway in human hepatocellular carcinoma.24805933
Adenocarcinoma of lung (disorder)Epigenetic AlterationsUp-regulation of microRNA-183-3p is a potent prognostic marker for lung adenocarcinoma of female non-smokers.24805982
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-183 (miR-183) has various expression patterns in types of human cancers.24805982
melanomaEpigenetic AlterationsHere, we explore the application of chromatin conformation capture technology to generate a diagnostic epigenetic barcode for melanoma.24807349
Carcinoma, MetastasisEpigenetic AlterationsLong non-coding RNAs (lncRNAs) play key roles in the progression and metastasis of some carcinomas.24810858
Squamous cell carcinoma of esophagusEpigenetic AlterationsLong noncoding RNA SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis.24810925
NeoplasmsEpigenetic AlterationsWe studied if DNA methylation might contribute to inactivation of gene/microRNA (miRNA) in the TP53 tumour suppressor network.24811488
Acute Promyelocytic LeukemiaEpigenetic AlterationsEpigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia.24811488
NeoplasmsEpigenetic AlterationsmiR-34b/c is a tumour suppressor miRNA in APL.24811488
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/b-catenin signaling pathway genes.24811787
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsThe onset and progression of colorectal cancer (CRC) involves a cascade of genetic and/or epigenetic events.24811787
Sample Size CalculationEpigenetic AlterationsThe aetiology of systemic sclerosis (SSc) is not clear, but there is an emerging evidence of gene-specific epigenetic dysregulation in the pathogenesis of SSc.24812288
Aortic Aneurysm, AbdominalEpigenetic AlterationsPrevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice.24812324
Aortic Aneurysm, AbdominalEpigenetic AlterationsTargeting these miRNAs may be a novel therapeutic strategy to prevent AAA.24812324
Diabetes Mellitus, Non-Insulin-Dependent, InflammationEpigenetic AlterationsAltered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes.24812430
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsHowever, 15,627 sites, representing 7,046 genes including PPARG, KCNQ1, TCF7L2, and IRS1, showed differential DNA methylation in adipose tissue from unrelated subjects with T2D compared with control subjects.24812430
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsA total of 1,410 of these sites also showed differential DNA methylation in the twins discordant for T2D.24812430
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsGenetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D).24812430
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsTaken together, subjects with T2D exhibit multiple transcriptional and epigenetic changes in adipose tissue relevant to the development of the disease.24812430
Medullary carcinoma of thyroid, Aggressive behaviorEpigenetic AlterationsEpigenetic-related gene expression profile in medullary thyroid cancer revealed the overexpression of the histone methyltransferases EZH2 and SMYD3 in aggressive tumours.24813658
Primary malignant neoplasmEpigenetic AlterationsEpigenetic control of gene expression plays a major influence in the development and progression of many cancer types.24813658
Lymphoma, FollicularEpigenetic AlterationsHypermethylation of DAPK1 promoter gene was found to be a frequent epigenetic alteration in follicular lymphoma (FL).24814955
Ductal Breast CarcinomaEpigenetic AlterationsThe results suggest that methylation of promoter sites of ESR1 and PGR is a relatively uncommon event in ductal and lobular breast cancer, and also suggest that the determination of epigenetic states of ESR1 and PGR could represent an alternative or complement to the histopathological expression analysis.24815444
Prostate Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsTumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer.24815849
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur recent studies of the microRNA (miRNA) expression signature in prostate cancer (PCa) indicated that miRNA-218 (miR-218) was significantly downregulated in clinical specimens, suggesting that miR-218 might act as a tumor-suppressive miRNA in PCa.24815849
Primary malignant neoplasmEpigenetic AlterationsRestoration of miR-218 in PCa cell lines (PC3 and DU145) revealed that this miRNA significantly inhibited cancer cell migration and invasion.24815849
Rheumatoid Arthritis, Right armEpigenetic AlterationsWe hypothesized that the aberrant expression of microRNAs (miRNAs) in rheumatoid arthritis (RA) T cells was involved in the pathogenesis of RA.24816316
Right armEpigenetic AlterationsThe expression profile of 270 human miRNAs in T cells from the first five RA patients and five controls were analysed by real-time polymerase chain reaction.24816316
Right armEpigenetic AlterationsTwelve miRNAs exhibited potentially aberrant expression in RA T cells compared to normal T cells.24816316
Breast Cancer CellEpigenetic AlterationsMicroRNAs have been demonstrated to have a role in susceptibility and prognosis of various types of human cancer.24816919
Glioblastoma MultiformeEpigenetic AlterationsMicroRNA expression signatures and their correlation with clinicopathological features in glioblastoma multiforme.24817689
Glioblastoma MultiformeEpigenetic AlterationsThe increasing interest in identifying molecular biomarkers to determine patient prognosis in glioblastoma multiforme (GBM) has resulted in several microRNA (miRNA)-based signatures able to predict progression-free and overall survival.24817689
NeoplasmsEpigenetic AlterationsIn total, 161 miRNAs were shown to cluster the GBM tumor samples into long- and short-term-surviving patients.24817689
Clinical CoordinatorEpigenetic AlterationsMicro(mi)RNAs are noncoding RNAs that recognize their cognate messenger (m)RNA targets by sequence-specific interactions with the 3 untranslated region and are involved in the multistep process of CRC development.24817781
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42.24817781
Stomach CarcinomaEpigenetic AlterationsDysregulation of microRNA biosynthesis enzyme Dicer plays an important role in gastric cancer progression.24817967
DICER1 protein, humanEpigenetic AlterationsDicer is one of the most important components in microRNA biogenesis.24817967
Prostate Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsTumor-suppressive microRNA-29s inhibit cancer cell migration and invasion via targeting LAMC1 in prostate cancer.24820027
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur recent studies of microRNA (miRNA) expression signatures revealed that microRNA-29s (miR-29s; including miR-29a/b/c) were significantly downregulated in prostate cancer (PCa) and was a putative tumor-suppressive miRNA family in PCa.24820027
Carcinogenesis, Metastasis, Primary malignant neoplasmEpigenetic AlterationsRecognition of tumor-suppressive miRNA-mediated cancer pathways provides new insights into the potential mechanisms of PCa oncogenesis and metastasis, and suggests novel therapeutic strategies for treating this disease.24820027
Nasopharyngeal carcinomaEpigenetic AlterationsDifferential expression of long noncoding RNA in primary and recurrent nasopharyngeal carcinoma.24822202
Colorectal CarcinomaEpigenetic AlterationsRelationship between miRNA-338-3p expression and progression and prognosis of human colorectal carcinoma.24824250
Ulcerative ColitisEpigenetic AlterationsDNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis.24825593
InflammationEpigenetic AlterationsMicroRNA-124a (miR - 124a) is known to have tumor-suppressive function and be methylation-silenced during exposure to chronic inflammation.24825593
Colorectal Cancer PathwayEpigenetic AlterationsPrognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer.24825851
Colorectal Cancer PathwayEpigenetic AlterationsIn summary, EPAS1 is transcriptionally regulated by DNA methylation in colorectal cancer.24825851
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation and mRNA status of EPAS1 have novel prognostic potential for colorectal cancer.24825851
Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsMicroRNA-335 inhibits invasion and metastasis of colorectal cancer by targeting ZEB2.24829139
NeoplasmsEpigenetic AlterationsMicroRNAs have been suggested to play a vital role in regulate tumor progression and invasion.24829139
Primary malignant neoplasmEpigenetic AlterationsGrowing number of long noncoding RNAs (lncRNAs) are emerging as new modulators in cancer origination and progression.24833086
Heart failure, Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsMicroRNA (miRNAs) is demonstrated to be present in the blood of humans and has been increasingly suggested as a novel biomarker for various pathological processes in the heart, including myocardial infarction, myocardial remodeling and progression to heart failure.24833470
Heart failureEpigenetic AlterationsAdditionally, increased miRNA levels were strongly associated with increased risk of mortality or heart failure within 6 months for miR-328 (OR 7.35, 95 % confidence interval 1.07-17.83, P < 0.001) and miR-134 (OR 2.28, 95 % confidence interval 1.03-11.32 P < 0.001).24833470
Heart failureEpigenetic AlterationsIn conclusion, circulating miR-328 and miR-134 could be potential indicators for AMI, and the miRNA levels are associated with increased risk of mortality or development of heart failure.24833470
Heart failure, InfarctionEpigenetic AlterationsMiRNAs were assessed for discrimination of a clinical diagnosis of AMI and for association with primary clinical endpoint defined as a composite of cardiogenic death and development of heart failure within 6 months after infarction.24833470
Adenocarcinoma of lung (disorder)Epigenetic AlterationsA MicroRNA cluster at 14q32 drives aggressive lung adenocarcinoma.24833665
Adenocarcinoma of lung (disorder)Epigenetic AlterationsTo determine whether different subtypes of lung adenocarcinoma (AC) have distinct microRNA (miRNA) expression profiles, and to identify miRNAs associated with aggressive subgroups of resected lung AC.24833665
NeoplasmsEpigenetic AlterationsmiR-411 knockdown significantly reduced cell migration in lung AC cell lines and this miRNA was overexpressed in tumors from patients who relapsed systemically.24833665
NeoplasmsEpigenetic AlterationsUnsupervised hierarchical clustering of 356 miRNAs identified 3 major clusters of lung AC correlated with stage (P = 0.023), tumor differentiation (P < 0.003), and IASLC histologic subtype of lung AC (P < 0.005).24833665
Transitional cell carcinoma of bladderEpigenetic AlterationsDown-regulated microRNA-101 in bladder transitional cell carcinoma is associated with poor prognosis.24834983
Transitional cell carcinoma of bladderEpigenetic AlterationsDown-regulation of microRNA-101 (miR-101) expression has been linked to bladder transitional cell carcinoma (BTCC) development.24834983
Colorectal Neoplasms, NeoplasmsEpigenetic AlterationsEpigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.24837038
Degenerative polyarthritisEpigenetic AlterationsWe demonstrated that global DNA methylation using a high-density array can be a powerful tool in the characterization of OA at the molecular level.24838673
NeoplasmsEpigenetic AlterationsEpigenetic alteration of tumor suppressor genes by promoter hypermethylation has played a key role in tumorigenesis, which is an important mechanism as indispensable as gene deletion and mutation.24839112
Malignant tumor of colon, MetastasisEpigenetic AlterationsLong non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer.24840737
Malignant Neoplasms, MetastasisEpigenetic AlterationsHOTAIR, a cancer-associated long non-coding RNA (lncRNA), is a powerful biomarker of metastasis and poor prognosis in a diverse group of cancers.24840737
Cerebral InfarctionEpigenetic AlterationsIdentification of miRNA-21 and miRNA-24 in plasma as potential early stage markers of acute cerebral infarction.24841240
Colorectal Cancer PathwayEpigenetic AlterationsGlobal fecal microRNA profiling in the identification of biomarkers for colorectal cancer screening among Asians.24841830
Clinical CoordinatorEpigenetic AlterationsGlobal miRNA profiling uncovered 17 fecal markers (p<0.05) differentially regulated in CRC.24841830
NeoplasmsEpigenetic AlterationsNotably, a discrete set of aberrant miRNAs occurred within the tumor, indicating the presence of contributors beyond the exfoliation of tumor cells to the fecal miRNA profile.24841830
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsHypermethylation of tumor suppressor promoters is generally accepted to indicate poor prognosis in glioma; however, the DNA methylation patterns associated with different glioma prognoses remain to be elucidated.24842301
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is a potential biomarker for early cancer detection.24844223
Liver carcinomaEpigenetic AlterationsHistone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma.24844570
Kidney DiseasesEpigenetic AlterationsGlobal and specific histone acetylation pattern in patients with Balkan endemic nephropathy, a worldwide disease.24845033
Mesothelial NeoplasmsEpigenetic AlterationsHaving in mind a possible mechanism and biological role of epigenetic chromatin modification in urothelial tumor development they obtained results may open opportunity for selective therapeutic interventions in patients with BEN.24845033
Malignant tumor of cervixEpigenetic AlterationsRegarding viral DNA methylation, the E2BS1 showed a significantly higher mean methylation frequency compared to E2BS3/4, as previously observed in high-grade precancerous lesions of the uterine cervix.24845262
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs), the endogenous noncoding RNAs, are involved in carcinogenesis.24846066
Primary malignant neoplasmEpigenetic AlterationsTwo miRNAs, miR-21 and miR-106b were found up-regulated in cancer tissues (P=0.0012 and P<0.001, respectively), while miR-375 down-regulated (P<0.001).24846066
NeoplasmsEpigenetic AlterationsOur preliminary data suggest that three miRNAs, miR-21, miR-106b and miR- 375 might become novel tumor markers for LSCC diagnosis.24846066
MetastasisEpigenetic AlterationsMiRNAs have been shown to have important role in oncogenesis, invasion, and metastasis via epigenetic post-transcriptional gene regulation.24846313
Breast Carcinoma, MetastasisEpigenetic AlterationsmiRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.24846313
Metastasis, Primary malignant neoplasmEpigenetic AlterationsThe expression of miRNAs in patients with primary breast cancer with LN metastasis and that without LN metastases was compared by miRNA microarray.24846313
MetastasisEpigenetic AlterationsThe miRNA microarray initially identified that eight miRNAs (miR-206, miR-3923, miR-181a, miR-92a, miR-421, miR-339-5p, miR-3196, and miR-29b) were downregulated in LN metastasis group, whereas five miRNAs (miR-542-5p, miR-200a, miR-564, miR-451, miR-30c, miR-200b, miR-191-3p, miR-142-5p, and miR-185-5p) were upregulated in LN group when compared with those in NLN group.24846313
Malignant Neoplasms, Prostate Cancer PathwayEpigenetic AlterationsMolecular markers that can discriminate indolent cancers from aggressive ones may improve the management of prostate cancer and minimize unnecessary treatment.Aberrant DNA methylation is a common epigenetic event in cancers and HOXD3 promoter hypermethylation (H3PH) has been found in prostate cancer.24847526
B-Cell LymphomasEpigenetic Alterations[Plasma DNA methylation of shp1 in patients with diffuse large B cell lymphoma].24851890
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsAberrant DNA methylation at CpG islands has been implicated as a critical player in colorectal cancer (CRC).24852431
Primary malignant neoplasmEpigenetic AlterationsFurthermore, WIF1 significantly increased the expression of microRNAs pri-let-7a and pri-miR-200c, negative regulators of stemness and cancer progression.24853424
Malignant NeoplasmsEpigenetic AlterationsMiR-155 is one of most commonly upregulated miRNAs in malignancies, and regulates multiple pro-oncogenic pathways.24854560
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) regulate gene expression and act as tumor suppressors or enhancers in oncogenesis.24854593
Malignant Neoplasms, DiseaseEpigenetic AlterationsMicroRNAs (miRNAs) are stably expressed in serum, which could serve as great potential prognostic biomarkers in a variety of diseases, including various cancers.24858372
Diffuse Large B-Cell LymphomaEpigenetic AlterationsThe expression levels of these five serum miRNAs may serve as novel prognostic biomarkers to predict the clinical outcome of DLBCL patients treated with R-CHOP regimen.24858372
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsAberrant DNA methylation is a common epigenetic alteration involved in colorectal cancer (CRC).24861485
Breast CarcinomaEpigenetic AlterationsAssociation of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients.24865188
Bone Cysts, AneurysmalEpigenetic AlterationsLevels of miRNA-93 differed significantly in core biopsies of LABC patients with different expressions of ER (estrogen receptor) and PR (progesterone receptor).24865188
Breast CarcinomaEpigenetic AlterationsThe assessment of core biopsy miRNA profiles and receptor-based subtypes may identify new signaling pathways for improved breast cancer classification.24865188
Malignant tumor of colonEpigenetic AlterationsSpecifically, differences in miRNA expression levels of miR-182 may contribute to decreased survival in AA colon cancer patients.24865442
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer (CRC) incidence and mortality are higher in African Americans (AAs) than in Caucasian Americans (CAs) and microRNAs (miRNAs) have been found to be dysregulated in colonic and other neoplasias.24865442
Malignant tumor of colon, Primary malignant neoplasmEpigenetic AlterationsDifferential expression of miRNAs in colon cancer between African and Caucasian Americans: implications for cancer racial health disparities.24865442
Malignant tumor of colonEpigenetic AlterationsmiRNAs may play a role in the differences between AA and CA colon cancer.24865442
Malignant Neoplasms, Childhood LeukemiaEpigenetic AlterationsThe extent and role of aberrant DNA methylation in promoter CpG islands (CGIs) have been extensively studied in leukemia and other malignancies.24866170
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAmong genetic mutations in AML, DNMT3A mutations showed the most prominent association with the DNA methylation pattern, characterized by hypomethylation of CGIs (as compared with DNMT3A wild type cases).24866170
Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsIn conclusion, we show that, in CN-AML, the most pronounced changes in DNA methylation occur in non-CGI regions and that DNMT3A mutations confer a pattern of global hypomethylation that specifically targets HOX genes.24866170
Breast CarcinomaEpigenetic AlterationsA novel panel of microRNAs provides a sensitive and specific tool for the diagnosis of breast cancer.24866395
Breast CarcinomaEpigenetic AlterationsThe results demonstrated that four out of the six candidate miRNAs were significantly downregulated in breast cancer patients (miR-451, P=0.000; miR-148a, P=0.021; miR-27a, P=0.013 and miR-30b, P=0.001).24866395
Breast CarcinomaEpigenetic AlterationsA panel of miRNAs consisting of the four downregulated miRNAs was able to distinguish breast cancer from healthy controls, with an area under the receiver operating characteristic curve of 95.3%, a sensitivity of 94.7% and a specificity of 82.8%.24866395
Breast CarcinomaEpigenetic AlterationsThus, this panel of miRNAs may be used as a sensitive and specific tool for the diagnosis of breast cancer.24866395
Autism Spectrum DisordersEpigenetic AlterationsMosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder.24875834
Liver carcinomaEpigenetic AlterationsTo analyze the expression profiles of long non-coding RNAs (lncRNAs) in hepatocellular carcinoma.24876753
Primary malignant neoplasmEpigenetic AlterationsSmall noncoding microRNAs (miRNAs) regulate gene expression at posttranscriptional level, thus playing an important role in many aspects of cell pathophysiology, including cancerogenesis and cancer progression.24877083
Leukemia, Myelocytic, AcuteEpigenetic AlterationsComparison of promoter DNA methylation and expression levels of genes encoding CCAAT/enhancer binding proteins in AML patients.24878001
melanomaEpigenetic AlterationsMicroR-125b is a miRNA whose down-regulation seems to be implicated in melanoma progression.24878024
Aggressive behavior, melanomaEpigenetic AlterationsMalignant melanoma is an aggressive tumor that produces exosomes, which contain microRNAs (miRNAs) that could be of utility in following tumoral cell dysregulation.24878024
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsHigh levels of global DNA methylation are an independent adverse prognostic factor in a series of 90 patients with de novo myelodysplastic syndrome.24880536
SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsThe prognostic impact of global DNA methylation and hydroxymethylation was assessed in 90 patients with de novo myelodysplastic syndrome (MDS).24880536
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsThis study suggests that global DNA methylation predicts overall survival in myelodysplastic syndromes.24880536
Hypertensive diseaseEpigenetic AlterationsDNA methylation of human telomerase reverse transcriptase associated with leukocyte telomere length shortening in hyperhomocysteinemia-type hypertension in humans and in a rat model.24882549
NeoplasmsEpigenetic AlterationsWe found that rDNA locus tended to be hypermethylated in tumor compared to matched normal breast tissues and that the DNA methylation level of several CpG units within the rDNA locus was associated to nuclear grade and to nucleolar size of tumor tissues.24884608
Mammary NeoplasmsEpigenetic AlterationsIn conclusion, we suggest that rDNA is an important target of epigenetic regulation in breast tumors and that rDNA methylation level is associated to nucleolar size.24884608
Stomach CarcinomaEpigenetic AlterationsUbiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells.24885194
Stomach CarcinomaEpigenetic AlterationsTwo gastric cancer cell lines were treated with IGF-I to induce EMT and levels of transcription factor ZEB2 and microRNA-200c (miR-200c) were measured.24885194
Prostate Cancer Pathway, Prostatic Cancer, Castration-ResistantEpigenetic AlterationsMoreover, site-specific DNA methylation may play an important role in miR-146a expression in androgen-dependent prostate cancer progression to androgen-independent prostate cancer and therefore provides a potentially useful biomarker for assessing drug efficacy in prostate cancer.24885368
BehaviorEpigenetic AlterationsmicroRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors.24886316
Lymphoid leukemiaEpigenetic AlterationsPolymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding.24886876
Childhood LeukemiaEpigenetic AlterationsMicroRNA dysregulation is a common event in leukemia.24886876
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMutations in epigenetic modifiers were reported in patients with acute myeloid leukaemia (AML) including mutations in DNA methyltransferase 3A gene (DNMT3A) in 20%-30% patients and mutations in isocitrate dehydrogenase 1/2 gene (IDH1/2) in 5%-15% patients.24887327
Ovarian Serous Adenocarcinoma, Cessation of lifeEpigenetic AlterationsProgrammed cell death 4 and microRNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions.24888238
Neoplasms, Cessation of lifeEpigenetic AlterationsProgrammed cell death 4 (PDCD4) is a tumor suppressor gene whose expression is directly controlled by microRNA-21 (miR-21).24888238
Squamous cell carcinoma of esophagusEpigenetic AlterationsComparison of long non-coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma.24888564
Primary malignant neoplasmEpigenetic AlterationsNon-coding RNAs, in particular microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been widely reported to be important in the regulation of tumorigenesis and cancer development.24888564
Esophageal NeoplasmsEpigenetic AlterationsHowever, to the best of our knowledge, investigation of the expression profiles of lncRNAs and a comparison of the involvement of lncRNAs, miRNAs and messenger RNAs (mRNAs) in esophageal tumorigenesis and development have not previously been performed.24888564
Squamous cell carcinoma of esophagusEpigenetic AlterationsFurthermore, the results indicated a high level of similarity in the potential function of lncRNAs, miRNAs and mRNAs in the processes of ESCC development.24888564
MMP8 wt AlleleEpigenetic AlterationsOur findings indicate that both genetic and epigenetic RB1 changes may contribute to the pathogenesis of HNC in the Pakistani population.24888624
Adrenocortical carcinomaEpigenetic AlterationsMicroRNA expression patterns in adrenocortical carcinoma variants and clinical pathologic correlations.24890943
Ductal CarcinomaEpigenetic AlterationsVGLL1 and miR-934 expression miRNA profiling was carried out on frozen samples of grade 3 invasive ductal carcinomas.24891455
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsRNA-seq data from The Cancer Genome Atlas (TCGA) was used to confirm differences in VGLL1 and miR-934 expression in different breast cancer subtypes, and to correlate their expression with that of other genes and miRNAs.24891455
Breast Carcinoma, Triple-Negative Breast Cancer FindingEpigenetic AlterationsOf 28 miRNAs differentially expressed in estrogen receptor (ER)-positive and ER-negative grade 3 breast carcinomas, miR-934 was most strongly upregulated in ER-negative carcinomas, and its expression was correlated with that of VGLL1.24891455
Clinical CoordinatorEpigenetic AlterationsAdditionally, TaqMan Human MicroRNA Array Set v2.0 was used to profile the expression of 667 miRNAs in 14 normal colon mucosa and 46 microsatellite stable stage II CRC patients.24892549
Clinical CoordinatorEpigenetic AlterationsFinally, combining the functional screening with profiling of CRC tissue samples we identified clinically relevant miRNAs and miRNA targets in CRC.24892549
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) play a critical role in many biological processes and are aberrantly expressed in human cancers.24892549
Colorectal Cancer PathwayEpigenetic AlterationsFunctional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer.24892549
NeoplasmsEpigenetic AlterationsParticular miRNAs function either as tumor suppressors or oncogenes and appear to have diagnostic and prognostic significance.24892549
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsAlthough numerous miRNAs are dys-regulated in colorectal cancer (CRC) only a small fraction has been characterized functionally.24892549
Clinical CoordinatorEpigenetic AlterationsWe conclude that the high-throughput screening successfully identified miRNAs that induce apoptosis and/or inhibit proliferation in CRC cells.24892549
palladiumEpigenetic AlterationsIn addition, we showed a reduced percentage of DNA methylation in the 5UTR region of ADORA2A in advanced PD cases.24892887
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsWe obtained miRNA expression profiles and corresponding clinical information for 372 LUAD patients from The Cancer Genome Atlas (TCGA), and identified the most significantly altered miRNAs between tumor and normal samples.24893932
Liver carcinomaEpigenetic AlterationsThe microRNA-200 family--a potential diagnostic marker in hepatocellular carcinoma?24895326
Leukemia, Myelocytic, AcuteEpigenetic AlterationsImpact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.24895338
Malignant Neoplasms, MetastasisEpigenetic AlterationsCurcumin suppresses proliferation, migration, invasion, metastasis and angiogenesis and induces apoptosis by regulating multiple signalling pathways and miRNAs in a wide variety of human malignancies.24896104
Carcinogenesis, Nasopharyngeal carcinomaEpigenetic AlterationsmiRNAs play crucial roles in various steps of carcinogenesis in nasopharyngeal carcinoma (NPC); thus, they could serve as critical therapeutic targets for NPC treatment.24896104
Breast CarcinomaEpigenetic AlterationsEvaluation of microRNA-10b prognostic significance in a prospective cohort of breast cancer patients.24897960
Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA-10b (miR-10b) has a prominent role in regulating tumor invasion and metastasis by targeting the HOXD10 transcriptional repressor and has been found up-regulated in several tumor types.24897960
Malignant NeoplasmsEpigenetic AlterationsAn accumulating amount of microRNAs (miRNA) were found aberrantly expressed in human cancers and regulate CSCs.24898358
Clinical CoordinatorEpigenetic AlterationsTo compare the performance of a new Septin9 DNA methylation based blood test with a fecal immunochemical test (FIT) for CRC screening.24901436
Degenerative polyarthritisEpigenetic AlterationsWe measured the expression of 380 miRNA in OA; 12 miRNA were overexpressed under the OA condition (p value, <=0.05; fold change, >2).24901787
Feel PainEpigenetic AlterationsSome metabolic pathways affected by the miRNA: mRNA ratio are signaling Bone morphogenetic proteins (BMP), Platelet-derived growth factor (PDGF), and Nerve growth factor (NGF), these latter two involved in the process of pain.24901787
Cartilage damageEpigenetic AlterationsSpecific miRNA that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism.24901787
Degenerative polyarthritisEpigenetic AlterationsSeveral miRNA could regulate genes and pathways related with development of the disease; eight of these circulating miRNA are described, to our knowledge, for first time in OA.24901787
Gallbladder Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer.24903309
Gallbladder CarcinomaEpigenetic AlterationsThe precise functions and mechanisms of microRNAs (miR) in gallbladder cancer (GBC) remain elusive.24903309
PsoriasisEpigenetic AlterationsWe identified several deregulated miRNAs in the blood from patients with psoriasis including miR-223 and miR-143 which were found to be significantly upregulated in the PBMCs from patients with psoriasis compared with healthy controls (FCH=1.63, P<0.01; FCH=2.18, P<0.01, respectively).24909097
NeoplasmsEpigenetic AlterationsLoss of heterozygosity (LOH) and promoter hypermethylation analysis revealed that deletion and/or aberrant epigenetic modulation of PCDH20 gene account for its downregulation, at least in a fraction of tumour specimens.24910204
ovarian neoplasmEpigenetic AlterationsCirculating microRNA expression profiles in ovarian cancer.24911418
Breast Cancer CellEpigenetic AlterationsRecent studies have suggested that miRNA deregulation is associated with the initiation and progression of human cancer.24911418
ovarian neoplasmEpigenetic AlterationsOur results demonstrated that expression levels of eight miRNAs were significantly upregulated in patients with ovarian cancer when compared with a control group (p < 0.05).24911418
ovarian neoplasmEpigenetic AlterationsExpression levels of four miRNAs were found significantly downregulated in patients with ovarian cancer (p < 0.05).24911418
ovarian neoplasmEpigenetic AlterationsIn addition, 10 miRNAs were expressed only in the ovarian cancer group and miR-138-5p of these miRNAs is ovarian specific.24911418
ovarian neoplasmEpigenetic AlterationsIn conclusion, our study suggests that detecting these ovarian cancer specific miRNAs in plasma might serve as novel non-invasive biomarkers for ovarian cancer.24911418
Ischemic strokeEpigenetic AlterationsmicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets.24911610
Ischemic strokeEpigenetic AlterationsmiRNA from peripheral blood cells of forty-eight patients with ischemic stroke and vascular risk factor controls were compared.24911610
Ischemic strokeEpigenetic AlterationsThe gene targets and pathways associated with ischemic stroke that may be regulated by the identified miRNA were characterized.24911610
Ischemic strokeEpigenetic AlterationsSeveral miRNA are differentially expressed in blood cells of patients with acute ischemic stroke.24911610
Ischemic stroke, Blood ClotEpigenetic AlterationsThese miRNA may regulate leukocyte gene expression in ischemic stroke including pathways involved in immune activation, leukocyte extravasation and thrombosis.24911610
Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsMicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression.24912422
Ovarian CarcinomaEpigenetic AlterationsEpigenetic alteration of p16 and retinoic acid receptor beta genes in the development of epithelial ovarian carcinoma.24913706
Carcinogenesis, ovarian neoplasmEpigenetic AlterationsOur results suggest that epigenetic alterations of p16 and RAR-b have an important role in ovarian carcinogenesis and that mechanism along with methylation plays a significant role in downregulation of RAR-b gene in ovarian cancer.24913706
Aggressive behavior, Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia.24914134
Aggressive behavior, Childhood Leukemia, Chronic Lymphocytic LeukemiaEpigenetic AlterationsHigh-level leukemia cell expression of micro-RNA 155 (miR-155) is associated with more aggressive disease in patients with chronic lymphocytic leukemia (CLL), including those cases with a low-level expression of z-chain-associated protein of 70 kD.24914134
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma, Hepatitis CEpigenetic AlterationsTo identify molecular characteristics to hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) through a comprehensive miRNAs expression profiling.24914240
Diffuse Large B-Cell LymphomaEpigenetic AlterationsA set of 52 miRNAs define a signature for HCV-associated DLBCL.24914240
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsIn addition, epigenetic mechanisms, such as changes in DNA methylation patterns, might have a role in the pathophysiology of T2D.24914535
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsTaken together, newly diagnosed, drug-naive type 2 diabetic patients display specific epigenetic changes at the TCF7L2 promoter as compared to age- and BMI-matched controls.24914535
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsMethylation in TCF7L2 promoter is further correlated with fasting glucose in peripheral blood DNA, which sheds new light on the role of epigenetic regulation of TCF7L2 in T2D.24914535
Hypopharyngeal Squamous Cell Carcinoma, NeoplasmsEpigenetic AlterationsIdentification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature.24918822
Primary malignant neoplasmEpigenetic AlterationsRestoration of miR-451a in cancer cell lines revealed that this miRNA significantly inhibited cancer cell migration and invasion.24918822
Malignant Neoplasms, Metastasis, NeoplasmsEpigenetic AlterationsIdentification of differentially expressed miRNAs and their regulated molecular targets in tumour cells might enhance our understanding of the molecular mechanisms of metastasis in human cancers.24918822
Choline Dehydrogenase, MitochondrialEpigenetic AlterationsSimilar data are lacking in Chinese population where different genetic, lifestyle and environmental factors may affect DNA methylation and its risk relationship with CHD.24918913
Diabetes Mellitus, Choline Dehydrogenase, MitochondrialEpigenetic AlterationsPotential CHD risk factors such as older age, elevated total cholesterol, and diagnosis of diabetes may have impact on global DNA methylation, whereby exerting their effect on CHD risk.24918913
CarcinogenesisEpigenetic AlterationsBuccal microRNA dysregulation in lung field carcinogenesis: gender-specific implications.24919547
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have been shown to be reliable early biomarkers in a variety of cancers including that of lung.24919547
Carcinoma of lungEpigenetic AlterationsWe ascertained whether the biomarker potential of miRNAs could be validated in microscopically normal and easily accessible buccal epithelial brushings from cigarette smokers as a consequence of lung cancer linked field carcinogenesis.24919547
Carcinoma of lungEpigenetic AlterationsWe found that compared to neoplasia-free subjects, a panel of 68 miRNAs were upregulated and 3 downregulated in the normal appearing buccal mucosal cells collected from patients harboring lung cancer (n=76).24919547
Chronic Obstructive Airway Disease, Adenocarcinoma of lung (disorder)Epigenetic AlterationsEpigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease.24921089
Primary NeoplasmEpigenetic AlterationsDNA methylation alterations on 1,928 probes occurred in N samples relative to normal lung tissue from patients without primary lung tumors, and were inherited by, or strengthened in, T samples.24921089
Chronic Obstructive Airway Disease, Aggressive behavior, Carcinogens, NeoplasmsEpigenetic AlterationsDNA methylation profiles reflecting carcinogenetic factors such as smoking and COPD appear to be established in non-cancerous lung tissue from patients with LADCs and may determine the aggressiveness of tumors developing in individual patients, and thus patient outcome.24921089
Breast Carcinoma, NeoplasmsEpigenetic AlterationsAs microRNAs (miRNA) may play important roles in tumorigenesis by regulating the expression of proto-oncogenes or tumor suppressor genes, the present study analyzed single nucleotide polymorphisms (SNPs) located in miRNA and miRNA-binding sites of various genes and their impact on prognosis for 452 patients with early breast cancer.24922658
Liver carcinomaEpigenetic AlterationsMicroRNA-224 upregulation and AKT activation synergistically predict poor prognosis in patients with hepatocellular carcinoma.24923856
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsPrevious evidence has shown that microRNA (miR)-224 may function as an onco-miRNA in hepatocellular carcinoma (HCC) cells by activating AKT signaling.24923856
Ovarian CarcinomaEpigenetic AlterationsExosome-derived miRNAs and ovarian carcinoma progression.24925027
Primary malignant neoplasmEpigenetic AlterationsCollectively, these data demonstrate the central role of miRNAs and their content in the biology of this cancer.24925027
Breast CarcinomaEpigenetic AlterationsThis is the first evidence of a significant association between genetic and epigenetic alterations in breast cancer using blood-based tests.24927296
Malignant neoplasm of thyroidEpigenetic AlterationsEpigenetic silencing of TSHR gene in thyroid cancer patients in relation to their BRAF V600E mutation status.24927793
Carcinoma of lungEpigenetic AlterationsA long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival.24927902
Squamous cell carcinoma of lungEpigenetic AlterationsSox2 overlapping transcript (Sox2ot) is a long noncoding RNA (lncRNA), localized on human chromosome 3q26.33, which is frequently amplified in lung squamous cell carcinomas (SCCs).24927902
atheroscleroticEpigenetic AlterationsThese data show a statistically significant correlation of the analyzed miRNA with increased lipids, specifically with a- and b-lipoproteins, and CRP and IL-1b levels in HL and/or HG sera, suggesting a contribution of these miRNAs to the atherosclerotic process.24928089
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCirculating microRNA profiling in patients with advanced non-squamous NSCLC receiving bevacizumab/erlotinib followed by platinum-based chemotherapy at progression (SAKK 19/05).24928469
NeoplasmsEpigenetic AlterationsPrognostic and predictive miRNA expression profiles were identified by Spearmans rank correlation test (percentage tumor shrinkage) or log-rank testing (for time-to-event endpoints).24928469
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCirculating miRNA profiling should further be validated in external cohorts for the selection and monitoring of systemic treatment in patients with advanced NSCLC.24928469
MIR29A geneEpigenetic AlterationsTen miRNAs were significantly associated with OS, with hsa-miR-29a being the strongest prognostic marker (HR=6.44, 95%-CI 2.39-17.33).24928469
Virus DiseasesEpigenetic AlterationsMicroRNA miR-J1-5p as a potential biomarker for JC virus infection in the gastrointestinal tract.24932487
Clinical CoordinatorEpigenetic AlterationsHerein, we determined the pattern of JCV miRNA expression in clinical specimens from healthy subjects and CRC patients.24932487
Clinical Coordinator, Colonic Neoplasms, Virus DiseasesEpigenetic AlterationsJC virus-specific miR-J1-5p miRNA is a potential biomarker for viral infection, and the lower expression in patients with colonic neoplasia highlights its biological role regulating oncogenic T-Ag expression in CRC.24932487
Primary malignant neoplasmEpigenetic AlterationsThe importance of the Piwi-interacting RNA (piRNA) pathway for germ cell maintenance, genome integrity, DNA methylation and retrotransposon control raises possible roles of this pathway in cancer.24932571
Stomach Carcinoma, MetastasisEpigenetic AlterationsMicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer.24933454
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) play an important role to contribute carcinogenesis.24933454
ArteriosclerosisEpigenetic AlterationsHomocysteine disrupts EPCs function via inducing the hypermethylation of DDAH2 promoter, suggesting a key role of epigenetic mechanism in the progression of atherosclerosis.24934151
Primary malignant neoplasmEpigenetic AlterationsThe Cancer Genome Atlas data were used to examine DNA methylation profiles at 17 CpG sites located in the MSH3 locus.24934723
NeoplasmsEpigenetic AlterationsThe TCGA data confirmed significantly higher DNA methylation level at the MSH3 promoter region in tumors (P = 0.0024).24934723
Liver carcinomaEpigenetic AlterationsSerum microRNA-210 as a predictive biomarker for treatment response and prognosis in patients with hepatocellular carcinoma undergoing transarterial chemoembolization.24935355
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsTumor specific epigenetic alterations can be used as a molecular markers of malignancy, which can lead to better diagnosis, prognosis and therapy.24935385
Clinical Coordinator, NeoplasmsEpigenetic AlterationsSomatic phosphatase and tensin homolog deleted on chromosome 10 (PTEN) mutations and deletions or epigenetic silencing have been observed in multiple tumor types including CRC.24935469
Malignant NeoplasmsEpigenetic AlterationsEmerging evidence has shown associations of microRNA-205 (miR-205) with crucial cell processes such as the epithelial-mesenchymal transition (EMT) and aberrant expression with tumorigenesis in many types of human malignancy.24935592
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe correlation between DNA methylation and RNA expression of a validated marker, SOX17, was examined in a validation cohort of 61 ESCC patients.24936140
ovarian neoplasm, NeoplasmsEpigenetic AlterationsTo understand the biology of tumor recurrence in epithelial ovarian cancer, more studies are necessary, including epigenetic modifications or additional mutations in other genes.24936796
Depression, CTCAEEpigenetic AlterationsSustained alterations in SERT gene expression profiles, possibly mediated by epigenetic modifications, are a frequent correlate of depression and may thus constitute a putative mediator of GxE interaction.24937096
diabeticEpigenetic AlterationsTreatment-naive, poorly controlled diabetic patients show a significant dysregulation of miRNAs involved in the regulation of the adiponectin pathway, a phenomenon that may be reversed, at least in part, by improved glycemic control.24937531
Primary malignant neoplasmEpigenetic AlterationsDNA methylation status is more reliable than gene expression at detecting cancer in prostate biopsy.24937670
Prostatic HyperplasiaEpigenetic AlterationsMicroarray profiling of gene expression and DNA methylation was performed on 16 benign prostatic hyperplasia (BPH) and 32 cancerous and non-cancerous prostate samples extracted by radical prostatectomy.24937670
Malignant Neoplasms, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsDNA methylation-based biomarkers reflect the prostate malignancy and might be useful in supporting clinical decisions for suspected PCa following an initial negative prostate biopsy.24937670
Breast CarcinomaEpigenetic AlterationsOncogenic microRNAs: miR-155, miR-19a, miR-181b, and miR-24 enable monitoring of early breast cancer in serum.24938880
Ovarian Serous AdenocarcinomaEpigenetic AlterationsCharacterization of microRNA expression in serous ovarian carcinoma.24939816
ovarian neoplasmEpigenetic AlterationsMiRNA expression profiling showed that 63 miRNAs were downregulated and 43 miRNAs were upregulated in serous ovarian cancer tissues compared with control tissues.24939816
Malignant neoplasm of ovaryEpigenetic AlterationsMicroRNAs (miRNAs) have been shown to be dysregulated in ovarian carcinomas.24939816
CarcinogenesisEpigenetic AlterationsThe results suggested that the aberrant expression of miRNAs is involved in ovarian carcinogenesis and thus these miRNAs may function as diagnostic and prognostic biomarkers.24939816
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) have important regulatory functions in cellular processes and have shown promising potential as prognostic markers for disease outcome in patients with cancer.24940606
Early-onsetEpigenetic AlterationsThe expression analysis of these miRNAs might be used as biomarkers of the BRCA mutation status of early-onset and/or familial BC.24942235
Leukemia, Myelocytic, AcuteEpigenetic AlterationsRecent advances in comprehensive genomic analyses in acute myeloid leukemia have revealed prevalent mutations in regulators of epigenetic phenomena including global DNA methylation status.24942948
LymphomaEpigenetic AlterationsThese results suggest that, in terms of 5 mC/5 hmC immunohistochemistry, B-cell lymphomas with different histological subtypes are associated with distinct global DNA methylation statuses that resemble those of their postulated normal counterparts.24942948
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsReduced expression of circulating microRNA-218 in gastric cancer and correlation with tumor invasion and prognosis.24944481
Primary malignant neoplasmEpigenetic AlterationsAberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development.24945256
Malignant Neoplasms, Liver carcinoma, Carcinogenesis, Hollings Cancer CenterEpigenetic AlterationsAberrant DNA methylation profiles are a characteristic feature of almost all types of cancers including hepatocellular carcinoma (HCC) and play an important role in carcinogenesis.24947038
Hollings Cancer CenterEpigenetic AlterationsHowever, a comparison between three disease cohorts (CH, LC & HCC) revealed no significant difference in levels of DNA methylation at DKK1 promoter.24947038
Ulcerative Colitis, Neoplastic disease, InflammationEpigenetic AlterationsThe lack of correlation between well-known IBD-associated SNPs and UC-neoplasia demonstrated in this study suggests that the development of neoplasia in patients with UC is associated with genetic determinants other than those that predispose to inflammation or results from posttranslational modifications or epigenetic factors rather than germline polymorphisms.24947639
Malignant neoplasm of gastrointestinal tractEpigenetic AlterationsWe have previously shown that gastrointestinal cancers display similar epigenetic aberrations.24948044
Colorectal Cancer Pathway, Cholangiocarcinoma, Malignant neoplasm of gastrointestinal tractEpigenetic AlterationsIn conclusion, the high methylation frequency of these genes in colorectal- as well as in gastric-, pancreatic- and bile duct cancer confirmed an epigenetic similarity between gastrointestinal cancer types, and simultaneously demonstrated their potential as biomarkers, particularly for colorectal cancer detection.24948044
Malignant Neoplasms, Gallbladder CarcinomaEpigenetic AlterationsLong non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer.24953832
Gallbladder CarcinomaEpigenetic AlterationsThe effects of HOTAIR and miRNA-130a on gallbladder cancer cell invasion and proliferation was tested using in vitro cell invasion and flow cytometric assays.24953832
Gallbladder CarcinomaEpigenetic AlterationsMoreover, a negative correlation between HOTAIR and miRNA-130a was observed in gallbladder cancer tissues.24953832
Malignant NeoplasmsEpigenetic AlterationsTogether, these results suggest that HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a.24953832
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs play important roles in cancer.24954107
Multidrug-resistant bacteriaEpigenetic AlterationsLong noncoding RNA MRUL promotes ABCB1 expression in multidrug-resistant gastric cancer cell sublines.24958102
Primary malignant neoplasm, Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur findings suggest that miR216a is a cancer suppressor miRNA and that overexpression of miR216a is a novel NSCLC treatment strategy.24958806
InflammationEpigenetic AlterationsEvidence suggests that HTLV-1, via the viral protein Tax, exploits CD4+ T cell plasticity and induces transcriptional changes in infected T cells that cause suppressive CD4+CD25+CCR4+ Tregs to lose expression of the transcription factor FOXP3 and produce IFN-g, thus promoting inflammation.24960164
Malignant neoplasm of urinary bladderEpigenetic AlterationsSerum microRNA expression signatures identified from genome-wide microRNA profiling serve as novel noninvasive biomarkers for diagnosis and recurrence of bladder cancer.24961907
Malignant neoplasm of urinary bladderEpigenetic AlterationsRecent advantages of serum microRNAs (miRNAs) open a new realm of possibilities for noninvasive diagnosis and prognosis of bladder cancer (BC).24961907
Prostate Cancer PathwayEpigenetic AlterationsOur findings strongly indicate that epigenetic silencing of GSTM2 and PENK is a common event in prostate cancer that could be used as a molecular marker for prostate cancer diagnosis.24961912
OsteosarcomaEpigenetic AlterationsTo quantify microRNA-9 (miR-9) concentrations in the serum of patients with osteosarcoma; to explore its relationship with clinicopathological characteristics and prognosis of osteosarcoma.24962996
HypertrophyEpigenetic AlterationsIn conclusions, miR-155 is a fibrosis-associated miRNA and may play important role in the pathogenesis of LF hypertrophy.24963214
Liver carcinomaEpigenetic AlterationsExpression of serum exosomal microRNA-21 in human hepatocellular carcinoma.24963487
NeoplasmsEpigenetic AlterationsAberrant DNA methylation is one of the main drivers of tumor initiation and progression.24963497
Traditional Serrated Adenoma, Colon CarcinomaEpigenetic AlterationsDNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability.24964857
melanomaEpigenetic AlterationsLong non-coding RNA BANCR promotes proliferation in malignant melanoma by regulating MAPK pathway activation.24967732
melanoma, Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been shown to be implicated in the complex network of cancer including malignant melanoma and play important roles in tumorigenesis and progression.24967732
melanoma, Metastatic malignant neoplasm to brainEpigenetic AlterationsDNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations.24968695
melanomaEpigenetic AlterationsLittle is known about the genetic and epigenetic alterations in melanoma brain metastases (MBMs).24968695
Malignant neoplasm of liverEpigenetic AlterationsMicroRNA-451 regulates activating transcription factor 2 expression and inhibits liver cancer cell migration.24968707
NeoplasmsEpigenetic AlterationsAccumulating evidence suggests that microRNAs (miRNAs) can function as oncogenes or as tumor suppressor genes depending on the tissue type or target.24968707
Primary malignant neoplasmEpigenetic AlterationsTherefore, clarification of the specific roles of miRNAs is vital for the diagnosis and treatment of cancer.24968707
Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (lncRNAs) play an important role in cancer occurrence and development.24969565
Diabetic Retinopathy, Vitreous humorEpigenetic AlterationsComparisons of microRNA expression profiles in vitreous humor between eyes with macular hole and eyes with proliferative diabetic retinopathy.24970617
Diabetic Retinopathy, PDR geneEpigenetic AlterationsWe compared the expression profiles of the miRNAs in the vitreous of eyes with macular hole (MH) to that in eyes with proliferative diabetic retinopathy (PDR).24970617
PDR geneEpigenetic AlterationsThe mean number of miRNAs expressed in the vitreous was 63 (55-69) in eyes with MH and 86 (65-117) in eyes with PDR.24970617
PDR geneEpigenetic AlterationsThe mean number of miRNAs expressed in the serum was 162 (159-167) in the MH patients and 142 (115-160) in the PDR patients.24970617
PDR geneEpigenetic AlterationsTwenty-six miRNAs were expressed in the vitreous of both MH and PDR eyes.24970617
PDR geneEpigenetic AlterationsIn addition, the mean fold changes of three miRNAs, hsa-miR-23a, hsa-miR-320a, and hsa-miR-320b, in the vitreous to serum were significantly higher in the PDR group than in the MH group.24970617
Fibrosis Assessment, PDR geneEpigenetic AlterationsThe expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.24970617
DysplasiaEpigenetic AlterationsMutations of genes involved in DNA methylation, splicing factors other than SF3B1, and genes of the RAS pathway and cohesin complex were independently associated with multilineage dysplasia and identified a distinct subset (51 of 245 patients, 20.8%).24970933
Primary malignant neoplasmEpigenetic AlterationsThe changes in DNA methylation status in cancer cells are characterized by hypermethylation of promoter CpG islands and diffuse genomic hypomethylation.24971511
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsOur findings suggest that miRNA-196a2 T/C polymorphism (rs11614913) is associated with an increased risk of CVD in type 2 diabetes patients.24972764
Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation in gene promoters is associated with aging and cancer, but the circumstances determining methylation change are unknown.24973978
Primary malignant neoplasmEpigenetic AlterationsLifestyle, including aspirin use, modulates age-associated DNA methylation change in the colonic epithelium and thereby impacts the evolution of cancer methylomes.24973978
Primary malignant neoplasmEpigenetic AlterationsAPA may lead to disruption of microRNA-mediated gene silencing in cancer cells via detachment of microRNA binding sites.24975429
Aggressive behavior, Primary malignant neoplasmEpigenetic AlterationsOur results indicate that the loss of PABPN1, a suppressor of APA, might promote tumor aggressiveness by releasing the cancer cells from microRNA-mediated gene regulation.24975429
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsMiRNA profiling of four PCa and four BPH patients with microarray revealed that miR-361-3p, miR-133b and miR-221 were significantly downregulated and miR-203 was upregulated in PSS of PCa patients.24976077
Prostate Cancer PathwayEpigenetic AlterationsIdentification of microRNAs differentially expressed in prostatic secretions of patients with prostate cancer.24976077
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsFour miRNAs, together and individually have much power (AUC; 0.950) than PSA has (AUC; 0.463) to discriminate PCa from BPH patients.24976077
Chemosensitivity, Primary malignant neoplasmEpigenetic AlterationsIn parallel, expression of TLR4 and MyD88 mRNA and regulatory microRNAs (miR-21 and miR-146a) was assessed, as well as in a series of chemosensitive and resistant cancer cells lines.24977712
Colorectal Cancer PathwayEpigenetic AlterationsUCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution.24977734
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cancer biology, and functional lncRNAs can be used for cancer diagnosis and prognosis.24977734
Carcinoma, Transitional CellEpigenetic AlterationsAn epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine.24980822
Degenerative polyarthritisEpigenetic AlterationsGenome-wide DNA methylation profiling of >485,000 methylation sites was performed on eroded and intact cartilage from within the same joint of 24 patients undergoing hip arthroplasty for OA.24980887
Degenerative polyarthritisEpigenetic AlterationsOur data implicate epigenetic dysregulation of a host of genes and pathways in OA, including a number of OA susceptibility genes.24980887
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression.24981248
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-630 is a prognostic marker for patients with colorectal cancer.24981248
Malignant NeoplasmsEpigenetic AlterationsAmong various microRNAs, miR-630 has recently been identified to be implicated in many critical processes in human malignancies.24981248
Cerebellar degeneration, MIR206 wt AlleleEpigenetic AlterationsThis study provides novel insight into the role of miRNA in cerebellar degeneration and suggests that miR-202 is a key miRNA mediating the pathogenesis of MSA.24981430
Breast Carcinoma, MIR206 wt Allele, Breast DiseasesEpigenetic AlterationsTo determine their relevance for breast cancer, we quantified the levels of MAGE-A1, -A2, -A3, -A12 and BORIS mRNA, as well as microRNAs let-7b and miR-202 in pre- and postoperative serum of 102 and 34 breast cancer patients, respectively, and in serum of 26 patients with benign breast diseases and 37 healthy women by real-time PCR.24983365
Breast Carcinoma, MIR206 wt AlleleEpigenetic AlterationsTransfection of breast cancer cells with synthetic microRNAs and their inhibitors showed that let-7b and miR-202 did not affect the protein expression of MAGE-A1.24983365
Stomach CarcinomaEpigenetic AlterationsIncreased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance.24984296
NeoplasmsEpigenetic AlterationsLong noncoding RNAs (lncRNAs) play an important role in basic physiological processes, also affect tumor occurrence and development.24984296
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsGastric juice long noncoding RNA used as a tumor marker for screening gastric cancer.24986041
melanomaEpigenetic AlterationsDNA methylation profiles in primary cutaneous melanomas are associated with clinically significant pathologic features.24986547
melanomaEpigenetic AlterationsDNA methylation studies have elucidated a methylation signature distinguishing primary melanomas from benign nevi and provided new insights about genes that may be important in melanoma development.24986547
Acute leukemiaEpigenetic Alterations[Effects of DNA methylation on expression of TIG1 gene in acute leukemia].24989270
NeoplasmsEpigenetic AlterationsDNA methylation of ID4 gene promoter occurred frequently in patients with AL and was found to be highly related to the tumor progression.24989275
Cardiovascular DiseasesEpigenetic AlterationsMicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs).24990426
Autoimmune thyroid diseaseEpigenetic AlterationsAssociations of single nucleotide polymorphisms in precursor-microRNA (miR)-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases.24990808
Primary malignant neoplasmEpigenetic AlterationsRecent advances in microRNAome have made microRNAs (miRNAs) a compelling novel class of biomarker in cancer biology.24992592
Primary malignant neoplasmEpigenetic AlterationsLong interspersed nuclear element-1 (LINE-1) methylation status, representing global DNA methylation levels, is associated with patient prognosis in several types of cancer.24992910
Hepatitis, Liver carcinomaEpigenetic AlterationsSerum microRNA 143 and microRNA 215 as potential biomarkers for the diagnosis of chronic hepatitis and hepatocellular carcinoma.24993656
Hepatitis, Hollings Cancer CenterEpigenetic AlterationsThe levels of the two mature miRNAs (miR-143 and miR-215) were detected by probe-based stem-loop quantitative reverse-transcriptase PCR (RT-qPCR) in controls, hepatitis and HCC patients.24993656
Mycobacterium InfectionsEpigenetic AlterationsmicroRNA-124 negatively regulates TLR signaling in alveolar macrophages in response to mycobacterial infection.24995397
Mycobacterium InfectionsEpigenetic AlterationsThe emerging roles of microRNAs (miRNAs) in regulating immune responses have attracted increasing attention in recent years; and the alveolar macrophages (AMs) are the main targets of mycobacterial infection, which play a pivotal role in the pathogenesis of Mycobacterium tuberculosis infection.24995397
Acute-On-Chronic Liver FailureEpigenetic AlterationsAberrant DNA methylation of G-protein-coupled bile acid receptor Gpbar1 predicts prognosis of acute-on-chronic hepatitis B liver failure.24995843
AsthmaEpigenetic AlterationsBy mapping genome-wide histone modification profiles for subsets of T cells isolated from peripheral blood of healthy and asthmatic individuals, we identified enhancers with known and potential roles in the normal differentiation of human TH1 cells and TH2 cells.24997565
Metastasis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25.24997798
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe role of epigenetics in distinguishing pathological and clinical subgroups in bladder cancer is not fully characterized.24998186
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsmiR-152 may act as a tumor suppressor miRNA by also targeting TNFRSF6B and is therefore a potential candidate biomarker for HCC diagnosis, prognosis and molecular therapy.24998573
AdenomaEpigenetic AlterationsWe observed that lower levels of LINE-1 DNA methylation in normal appearing background colon mucosa were associated with increased adenoma risk for males, and for both sexes combined.24998982
Malignant NeoplasmsEpigenetic AlterationsThe methylation of DNA is recognized as a key epigenetic mechanism and evidence for its role in the development of several malignancies is accumulating.24998982
Malignant neoplasm of urinary bladder, Primary malignant neoplasmEpigenetic AlterationsTumour-suppressive microRNA-24-1 inhibits cancer cell proliferation through targeting FOXM1 in bladder cancer.24999187
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsHere, we found that microRNA-24-1 (miR-24-1) is significantly reduced in bladder cancer (BC) tissues, suggesting that it functions as a tumour suppressor.24999187
HIV-1 Infection PathwayEpigenetic AlterationsThese data suggest that DNA methylation at the IL2 locus in CD4(+) T cells is coupled to immunosenescence and plays a critical role in the broad dysfunction that occurs in polyclonal T cells during HIV-1 infection.25001463
HIV InfectionsEpigenetic AlterationsEpigenetic repression of interleukin 2 expression in senescent CD4+ T cells during chronic HIV type 1 infection.25001463
NeoplasmsEpigenetic AlterationsThere may be key molecular differences (eg, DNA methylation changes) in tumors at high risk for progression.25003289
Malignant neoplasm of anusEpigenetic AlterationsEpigenetic events likely play a significant role in the progression of anal cancer and may serve as potential biomarkers.25003289
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsmiRNA expression was determined using TaqMan assays in 155 tumors from resected NSCLC patients.25003366
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are promising molecular markers in multiple cancers and show differences in expression depending on histological subtype.25003366
melanomaEpigenetic AlterationsAssociation of TNFRSF10D DNA-methylation with the survival of melanoma patients.25003639
Breast CarcinomaEpigenetic AlterationsAlterations in circulating miRNA levels following early-stage estrogen receptor-positive breast cancer resection in post-menopausal women.25004125
Primary malignant neoplasmEpigenetic AlterationsCirculating microRNAs (miRNAs) exhibit remarkable stability and may serve as biomarkers in several clinical cancer settings.25004125
Primary malignant neoplasmEpigenetic AlterationsThese specific miRNAs may be involved in tumorigenesis and could potentially be used to monitor whether all cancer cells have been removed at surgery and/or, subsequently, whether the patients develop recurrence.25004125
X-linked inheritance, Parkinsonian DisordersEpigenetic AlterationsBecause women carriers of the genetic changes specific for X-linked dystonia-parkinsonism are common in the Philippines, the epigenetic factor of nonrandom X-chromosome inactivation may contribute to the skewing of the sex prevalence of parkinsonism toward women in this country, warranting further investigation.25004170
Family historyEpigenetic AlterationsInactivation of SDH and another tricarboxylic acid cycle component, fumarate hydratase (FH), have both been associated with abnormalities of cellular metabolism, responsible for the activation of hypoxic gene response pathways and epigenetic alterations (eg, DNA methylation).25004247
Aggressive behavior, CHOANAL ATRESIA, POSTERIOR, NeoplasmsEpigenetic AlterationsIn summary, these results demonstrate that epigenetic regulation of miR-152/DNMT1 may play an important role in multiple events that contribute to the aggressiveness of PCa tumors, with an emphasis on AA PCa patients .25004396
Prostate Cancer PathwayEpigenetic AlterationsHerein, we probed the miRNA expression profile of novel AA and CA derived prostate cancer cell lines.25004396
NeoplasmsEpigenetic AlterationsWe found a unique miRNA signature associated with AA cell lines, independent of tumor status.25004396
Stomach Carcinoma, MetastasisEpigenetic AlterationsLarge-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis.25009298
Stomach CarcinomaEpigenetic AlterationsGenome-wide DNA methylation profiles between 4 metastatic and 4 nonmetastatic gastric carcinomas and their surgical margins (SM) were analyzed using methylated-CpG island amplification with microarray.25009298
Metastatic Gastric Carcinoma, Stomach CarcinomaEpigenetic AlterationsAn epigenetic biomarker panel for predicting gastric carcinoma metastasis could have significant clinical impact on the care of patients with gastric carcinoma.25009298
ObesityEpigenetic AlterationsThis study provides evidence that obesity influences age driven epigenetic changes, which provides a molecular link between aging and obesity.25010727
Islet Cell TumorEpigenetic AlterationsPrognostic relevance of aberrant DNA methylation in g1 and g2 pancreatic neuroendocrine tumors.25011998
Primary malignant neoplasmEpigenetic AlterationsThese data are consistent with functional relevance of allelic regulation of RAD52 expression by the rs7963551 SNP and miRNA let-7 in cancer cells.25012956
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsIn conclusion, our results support the hypothesis that genetic variants influencing miRNA-mediated regulation of tumor suppressor genes or oncogenes may contribute glioma susceptibility.25012956
Chronic Obstructive Airway DiseaseEpigenetic AlterationsDo epigenetic events take place in the vastus lateralis of patients with mild chronic obstructive pulmonary disease?25013984
Muscular Atrophy, muscle massEpigenetic AlterationsSeveral biological mechanisms including epigenetic events regulate muscle mass and function in models of muscle atrophy.25013984
Chronic Obstructive Airway Disease, Renal InsufficiencyEpigenetic AlterationsWe assessed whether the epigenetic profile may be altered in the vastus lateralis of patients with mild COPD, normal body composition, and mildly impaired muscle function and exercise capacity.25013984
Conventional (Clear Cell) Renal Cell Carcinoma, NeoplasmsEpigenetic AlterationsExpression of the tumor suppressive miRNA-23b/27b cluster is a good prognostic marker in clear cell renal cell carcinoma.25014580
Malignant neoplasm of urinary bladderEpigenetic AlterationsCell-free urinary microRNA-99a and microRNA-125b are diagnostic markers for the non-invasive screening of bladder cancer.25014919
HematuriaEpigenetic AlterationsHowever, the contaminated blood cells in patients with haematouria significantly altered the expression profiles of urinary microRNA, influencing the test accuracy.25014919
Carcinoma, Transitional CellEpigenetic AlterationsEvidence implicated the diagnostic significance of microRNAs in whole urine/urine sediments in urothelial carcinoma of the bladder (UCB).25014919
Malignant neoplasm of urinary bladder, Transitional cell carcinoma of ureterEpigenetic AlterationsHsa-miR-1 downregulates long non-coding RNA urothelial cancer associated 1 in bladder cancer.25015192
Diabetic RetinopathyEpigenetic AlterationsThus, in diabetic retinopathy, histone methylation at Gclc-ARE4 plays an important role in regulating the Nrf2-Gclc-GSH cascade.25016074
Diabetic RetinopathyEpigenetic AlterationsEpigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression.25016074
Secondary malignant neoplasm of prostateEpigenetic AlterationsEpigenetic gene regulation has been shown to trigger prostate cancer metastasis and androgen independence.25016185
Malignant neoplasm of liver, Hollings Cancer Center, NeoplasmsEpigenetic AlterationsThe present findings support the hypothesis that the oncogenic events leading to an ectopic activation of the Y-located protooncogene TSPY and/or inactivating mutation/epigenetic silencing of the X-located tumor suppressor gene TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners.25017435
Admitting diagnosisEpigenetic AlterationsIncreasing evidence has suggested that noncoding RNAs (ncRNAs) may be associated with the development of AD.25019275
Thyroid carcinomaEpigenetic AlterationsGenetic or epigenetic events probably play a part in promoting thyroid carcinoma.25019383
MLL Partial Tandem Duplication, NeoplasmsEpigenetic AlterationsTwenty gene mutations including class I, class II, class III of epigenetic regulators (IDH1, IDH2, TET2, DNMT3A, MLL-PTD, ASXL1, and EZH2), and class IV (tumor suppressor genes) were analyzed in 67 patients with AML-M0.25022553
Malignant tumor of colonEpigenetic AlterationsWe aim to clarify its epigenetic inactivation, biological function and clinical implication in colon cancer.25023701
Chondrogenic Neoplasm, MolecularEpigenetic AlterationsWith the characteristic accumulative process of somatic changes as a background, molecular defects in chondrogenesis and aberrant epigenetic control are primarily causative of both benign and malignant cartilaginous tumors.25024164
Clinical Coordinator, DysbiosisEpigenetic AlterationsGrowing evidence has demonstrated that epigenetic modifications and fecal microbiota changes, also known as dysbiosis, are associated with CRC pathogenesis and might be used as surrogate markers of CRC.25025467
NeoplasmsEpigenetic AlterationsThe aberrant expression of microRNAs (miRNAs) is always associated with tumor development and progression.25027403
spiromustineEpigenetic AlterationsThe distribution of coding mutations in driver genes and the correlation with SHM suggest CREBBP and AID to be potential modifiers of genetic and epigenetic co-evolution in FL.25027518
Ductal CarcinomaEpigenetic AlterationsBoth microarray and RT-qPCR techniques were used to assess miRNA expression levels in lymph node-positive and -negative human invasive ductal carcinoma tissues.25027758
Malignant neoplasm of breastEpigenetic AlterationsNon-protein-coding microRNAs (miRNAs) have recently been found to be deregulated in breast cancers and, in addition, to be correlated with several clinico-pathological features.25027758
Breast CarcinomaEpigenetic AlterationsHere, we specifically searched for differentially expressed miRNAs in high-risk breast cancer patients as compared to low-risk breast cancer patients.25027758
Adenocarcinoma of lung (disorder)Epigenetic AlterationsDifferences in miRNA expression in early stage lung adenocarcinomas that did and did not relapse.25028925
Adenocarcinoma of lung (disorder), Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe measured miRNA expression only from flash frozen stage I lung adenocarcinomas, excluding other NSCLC subtypes.25028925
NeoplasmsEpigenetic AlterationsA unique comparison between adjacent normal lung tissue from relapse and non-relapse groups revealed dramatically different miRNA expression, suggesting dysregulation of miRNA in the environment around the tumor.25028925
NeoplasmsEpigenetic AlterationsTo assess patient-to-patient variability, miRNA levels in the tumors were normalized to levels in matched adjacent normal lung tissue.25028925
Adenocarcinoma of lung (disorder)Epigenetic AlterationsTogether our analyses elucidated miRNA not previously linked to lung adenocarcinoma that likely have important roles in its development and progression.25028925
AdenocarcinomaEpigenetic AlterationsOur results also highlight the differences in miRNA expression in normal lung tissue in adenocarcinomas that do and do not recur.25028925
Secondary malignant neoplasm of female breastEpigenetic AlterationsInhibition of breast cancer metastasis with microRNA-302a by downregulation of CXCR4 expression.25030358
Malignant neoplasm of urinary bladderEpigenetic AlterationsUpregulation of the long noncoding RNA HOTAIR predicts recurrence in stage Ta/T1 bladder cancer.25030736
Malignant Neoplasms, Breast CarcinomaEpigenetic AlterationsLong noncoding RNA HOTAIR has been reported to be expressed in some human cancers such as breast cancer, and it may be positively correlated with patients prognosis.25030736
NeoplasmsEpigenetic AlterationsSuperimposition of the tumor tissues was carried out in patients with and without epigenetic changes.25031184
Malignant NeoplasmsEpigenetic AlterationsRapidly accumulating studies show that the long non-coding RNAs (lncRNAs) may play essential roles in cancers.25031695
Squamous cell carcinoma of esophagusEpigenetic AlterationsA novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma.25031703
Squamous cell carcinoma of esophagusEpigenetic AlterationsHere, we showed that a novel long non-coding RNA FOXCUT (FOXC1 promoter upstream transcript) and its neighboring gene FOXC1 played a similar important role in the oncogenesis and progression of esophageal squamous cell carcinoma (ESCC).25031703
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are noncoding RNAs that regulate multiple cellular processes during cancer progression.25031755
Primary malignant neoplasmEpigenetic AlterationsLow expression of miR-21 by transfection with miRNA expression plasmid led to a decrease in BCL2 expression, which was accompanied by reduced migration and proliferation of the cancer cells.25031780
Colorectal CarcinomaEpigenetic AlterationsIncreased expression of miRNA-182 in colorectal carcinoma: an independent and tissue-specific prognostic factor.25031782
CarcinogenesisEpigenetic AlterationsIncreasing evidence has revealed that miRNAs play a pivotal role in multiple processes of carcinogenesis, and are being explored as diagnostic, prognostic and predictive biomarker.25031782
Heart failureEpigenetic AlterationsThe rationale was to utilize a bioinformatics approach to identify miRNA binding sites in genes with single nucleotide mutations (SNPs) to discover pathways in heart failure (HF).25033200
AstrocytomaEpigenetic AlterationsPrognostic value of coexistence of abnormal expression of micro-RNA-200b and cyclic adenosine monophosphate-responsive element-binding protein 1 in human astrocytoma.25033730
Acute myocardial infarctionEpigenetic AlterationsLong noncoding RNAs in patients with acute myocardial infarction.25035150
SF3B1 wt Allele, Leukemia, Myelocytic, Acute, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsPatients with acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) may respond to treatment with epigenetic-modifying agents.25040094
Breast Cancer CellEpigenetic AlterationsmiRNA-21 (miR-21) appears to be important in the tumourigenesis of almost all types of human cancer.25041158
Stomach CarcinomaEpigenetic AlterationsMicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival.25043310
Breast CarcinomaEpigenetic AlterationsMicroRNA profile in very young women with breast cancer.25047087
Breast CarcinomaEpigenetic AlterationsTo our knowledge, this is the first time that a validated microRNA profile, distinctive to breast cancer in very young women, has been presented.25047087
Malignant tumor of colonEpigenetic AlterationsCombined nuclear expression of histone modifications H3K4me3, H3K9me3 and H4K20me3 is prognostic in early-stage colon cancer.25047223
Tetranitromethane, Malignant tumor of colonEpigenetic AlterationsThe histone methylation markers only showed prognostic value in early-stage (TNM stage I and II) colon cancer.25047223
Squamous cell carcinoma of esophagusEpigenetic AlterationsIdentification of a DNA methylome profile of esophageal squamous cell carcinoma and potential plasma epigenetic biomarkers for early diagnosis.25050929
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, AcuteEpigenetic AlterationsCombination epigenetic treatment (EGT) utilizing DNA methyl transferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi) may be more efficacious than single agent treatment in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).25051119
Stage II Colon Cancer AJCC v7Epigenetic AlterationsRedefining high-risk patients with stage II colon cancer by risk index and microRNA-21: results from a population-based cohort.25051407
NeoplasmsEpigenetic AlterationsMicroRNA-21 was analysed by qPCR based on tumour tissue.25051407
Stage II Colon Cancer AJCC v7Epigenetic AlterationsThis population-based study supports miRNA-21 as an additional prognostic biomarker in patients with stage II colon cancer.25051407
liposarcomaEpigenetic AlterationsLiposarcoma miRNA signatures identified from genome-wide miRNA expression profiling.25052748
liposarcomaEpigenetic AlterationsTo identify the miRNA expression profile of liposarcoma (LPS) that could facilitate detection of LPS, and provide the basis for further investigation of molecular-targeted therapeutic drugs.25052748
NeoplasmsEpigenetic AlterationsA real-time quantitative PCR assay was performed to analyze the expression of 1888 miRNAs from 25 LPS tumor tissue samples, 16 samples of adipose tissue adjacent to the tumors and 18 normal adipose tissue samples from patients with LPS.25052748
Neoplasms, LipomaEpigenetic AlterationsTen dysregulated miRNAs were identified that effectively distinguished LPS tissue from adipose tissue and benign lipoma tissue, and LPS tumor tissues from normal adipose tissues in LPS patients.25052748
Coronary RestenosisEpigenetic AlterationsA micro RNA-146a polymorphism is associated with coronary restenosis.25053223
Chlamydia psittaci infection, Ocular Adnexal LymphomaEpigenetic AlterationsGenome-wide DNA methylation profiles according to Chlamydophila psittaci infection and the response to doxycycline treatment in ocular adnexal lymphoma.25053874
NeoplasmsEpigenetic AlterationsMiRNAs are small noncoding RNAs that have been implicated in tumor development.25053875
PterygiumEpigenetic AlterationsMiRNA-221 negatively regulated downstream p27Kip1 gene expression involvement in pterygium pathogenesis.25053875
PterygiumEpigenetic AlterationsHere, we hypothesize that b-catenin-associated miRNA, miRNA-221, and downstream p27Kip1 gene expression are correlated with the pathogenesis of pterygium.25053875
SF3B1 wt AlleleEpigenetic AlterationsSpeculating that differences in the expression of genes and microRNA (miRNA) in control and MDS-derived erythroid progenitors may cause ineffective erythropoiesis, we sorted common megakaryocyte-erythroid progenitors (MEPs) in bone marrow cells from three lower-risk MDS patients, and compared expression levels of genes and miRNA with those from controls.25056847
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsExpressional changes of genes and miRNA in common megakaryocyte-erythroid progenitors from lower-risk myelodysplastic syndrome.25056847
SF3B1 wt AlleleEpigenetic AlterationsSome of these alterations in gene and miRNA expression may contribute to the pathogenesis of ineffective hematopoiesis in lower-risk MDS and provide molecular markers for sub-classification and making a prognosis.25056847
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miRNAs) are nonprotein-encoding RNAs that regulate gene expression and enable the distinction of benign from malignant tissues in human cancers.25057879
Goiter, Papillary thyroid carcinoma, F9 geneEpigenetic AlterationsmiRNA profiling was assessed by TaqMan Array Human MicroRNA A Cards v2.0 in pooled sera from 12 healthy subjects (HS), 12 nodular goiters (NG), and 12 patients with papillary thyroid cancer (PTC) (cohort 1).25057879
F9 geneEpigenetic AlterationsThese miRNAs were further validated in a second cohort of sera from 79 PTC, 80 NG, and 41 HS.25057879
Glioblastoma MultiformeEpigenetic AlterationsCorrelation between EGFR amplification and the expression of microRNA-200c in primary glioblastoma multiforme.25058589
Glioblastoma MultiformeEpigenetic AlterationsThis microRNA plays an important role in epithelial-mesenchymal transition, but its implication in the behavior of glioblastoma is largely unknown.25058589
NeoplasmsEpigenetic AlterationsOur results showed that microRNA-200c and E-cadherin expression are down-regulated, while ZEB1 is up-regulated, when tumors showed a high level of EGFR amplification.25058589
Hollings Cancer CenterEpigenetic AlterationsIn conclusion, the miRNA-149C>T and miR-499A>G polymorphisms were found to play an important role for HCC risk in China.25061729
Malignant Neoplasms, Stomach Carcinoma, MetastasisEpigenetic AlterationsLong non-coding RNA HOTAIR (HOX transcript antisense RNA) recently emerged as a promoter of metastasis in various cancers including gastric cancer.25063030
Stomach CarcinomaEpigenetic AlterationsMicroRNA 520d-3p inhibits gastric cancer cell proliferation, migration, and invasion by downregulating EphA2 expression.25063221
Primary malignant neoplasmEpigenetic AlterationsAberrant expression of microRNAs (miRNAs) has been shown to play important roles in cancer progression as a result of changes in expression of their target genes.25063221
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsDNA methylation of apoptosis genes in rectal cancer predicts patient survival and tumor recurrence.25064172
Primary malignant neoplasmEpigenetic AlterationsThe study of epigenetic regulation of apoptosis genes provides more insight in the tumorigenic process in rectal cancer and might be helpful in further refining treatment regimens for individual patients.25064172
Non-Small Cell Lung CarcinomaEpigenetic AlterationsPrognostic potential of microRNA-138 and its target mRNA PDK1 in sera for patients with non-small cell lung cancer.25064732
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsmicroRNA (miR)-138 has been recognized as a potential tumor suppressor via regulating 3-phosphoinositide-dependent protein kinase-1 (PDK1) expression in non-small cell lung cancer (NSCLC) cells.25064732
Communicable Diseases, Hepatitis, Hepatitis CEpigenetic AlterationsHepatic expression of miR-122, miR-126, miR-136 and miR-181a and their correlation to histopathological and clinical characteristics of patients with hepatitis C. It has been shown for hepatitis C virus (HCV) infection that host miRNAs contribute to the replication of the viral RNA genome.25065618
Post-Traumatic Stress DisorderEpigenetic AlterationsLongitudinal epigenetic variation of DNA methyltransferase genes is associated with vulnerability to post-traumatic stress disorder.25065861
Post-Traumatic Stress DisorderEpigenetic AlterationsEpigenetic differences exist between trauma-exposed individuals with and without post-traumatic stress disorder (PTSD).25065861
Post-Traumatic Stress Disorder, Traumatic injuryEpigenetic AlterationsIt is unclear whether these epigenetic differences pre-exist, or arise following, trauma and PTSD onset.25065861
Post-Traumatic Stress DisorderEpigenetic AlterationsDNAm among trauma-exposed individuals shows both longitudinal changes and pre-existing epigenetic states that differentiate individuals who are resilient versus susceptible to PTSD.25065861
Post-Traumatic Stress DisorderEpigenetic AlterationsThese distinctive DNAm differences within DNMT loci may contribute to genome-wide epigenetic profiles of PTSD.25065861
Gallbladder Carcinoma, CholecystitisEpigenetic AlterationsGlobal and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile.25066711
CholecystitisEpigenetic AlterationsGlobal DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0.01) and ESR1 (p = 0.05) were significantly different in GBC when compared with cholecystitis.25066711
Cirrhotic, Hypertensive diseaseEpigenetic AlterationsThe role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.25068403
Liver diseasesEpigenetic AlterationsCirculating miRNA-34a is increased in blood of patients with different liver diseases when compared to healthy controls.25068403
Cirrhotic, Portal HypertensionEpigenetic AlterationsHowever, the origin of miRNA-34a and its possible relationship with hemodynamics and outcome in cirrhotic patients with portal hypertension is unknown.25068403
Cirrhotic, Hypertensive diseaseEpigenetic AlterationsWe analyzed the levels of miRNA-34a in cirrhotic patients with severe portal hypertension.25068403
Cirrhotic, Hypertensive diseaseEpigenetic AlterationsEven though higher levels of miRNA-34a are possibly associated with better survival at long-term follow-up in cirrhotic patients with severe portal hypertension receiving TIPS, classical prognostic parameters predict the survival better.25068403
Pancreatic Intraductal Papillary Mucinous Neoplasm, CarcinomaEpigenetic AlterationsmiRNA hierarchical clustering demonstrated grouping of two main IPMN subgroups: low-grade IPMN versus high-grade IPMN and carcinoma.25069861
Breast CarcinomaEpigenetic AlterationsMicroRNA-495 induces breast cancer cell migration by targeting JAM-A.25070379
Breast CarcinomaEpigenetic AlterationsTaken together, our findings suggest that miR-495 could facilitate breast cancer progression through the repression of JAM-A, making this miRNA a potential therapeutic target.25070379
Breast Carcinoma, DiseaseEpigenetic AlterationsThe deregulated expression of miRNAs is associated with a variety of diseases, including breast cancer.25070379
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer.25071007
Suicide, BehaviorEpigenetic AlterationsIdentification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors.25073599
Colorectal Lymphoma, NeoplasmsEpigenetic AlterationsPrognostic microRNA expression signature from examination of colorectal primary and metastatic tumors.25075017
Clinical Coordinator, Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsWhile previous studies have described associations between specific microRNAs and colorectal cancer (CRC) metastasis, our understanding of microRNA regulation of metastatic spread remains largely unexplored.25075017
Secondary malignant neoplasm of liver, NeoplasmsEpigenetic AlterationsTo identify microRNAs critical for disease progression, we measured microRNA expression in primary CRC tumors and synchronous liver metastases in 19 cases using quantitative polymerase chain reaction (qPCR) arrays.25075017
Primary Neoplasm, Secondary malignant neoplasm of liverEpigenetic AlterationsWe identified 16 microRNAs significantly differentially expressed between primary tumors and liver metastases that distinguish primary tumors and liver metastases by hierarchical clustering.25075017
NeoplasmsEpigenetic AlterationsCombinations of microRNAs expressed in the primary tumor and in the metastatic tumor are associated with survival, but these signatures have no microRNAs in common.25075017
Diffuse Large B-Cell LymphomaEpigenetic AlterationsOur results may have important implications for treatment of DLBCL by epigenetic regulation.25076845
Primary malignant neoplasmEpigenetic AlterationsA single nucleotide polymorphism (SNP) in a miRNA sequence may alter miRNA expression and/or maturation, which was proposed to associate with the development and progression of cancer.25078482
Palmar-plantar erythrodysesthesia syndromeEpigenetic AlterationsComparisons of the plasma miRNA profiles after NAC and AC suggested that chemotherapy-induced miRNAs originated from both tumoral and non-tumoral compartments.25078559
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThis study is the first to demonstrate that NAC specifically induces miRNA expression in plasma and tumor tissue, which might be involved in the anti-tumor effects of chemotherapy in breast cancer patients.25078559
Breast CarcinomaEpigenetic AlterationsIn this article, we describe the modifications of circulating miRNAs profile after neoadjuvant chemotherapy (NAC) for breast cancer.25078559
Aggressive behaviorEpigenetic AlterationsAmong these miRNAs, miR-34a and miR-122 were highly upregulated, notably in pPR patients with aggressive breast cancer.25078559
Colorectal Cancer PathwayEpigenetic AlterationsGenetic variation in microRNA-binding site and prognosis of patients with colorectal cancer.25079514
Primary malignant neoplasmEpigenetic AlterationsSingle nucleotide polymorphisms (SNPs) located in the 3-UTR of miRNA target genes could affect miRNA-mediated gene regulation, thereby contributing to the susceptibility or prognosis of cancer.25079514
melanomaEpigenetic AlterationsDual labeling for the melanocyte lineage marker, MART-1, and the epigenetic marker, 5-hydroxymethylcytosine, a functionally significant indicator that has been shown to distinguish benign nevi from melanoma, was performed on all cases using immunohistochemistry and/or direct immunofluorescence.25081754
Colorectal Cancer PathwayEpigenetic AlterationsLow expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4.25081869
Pancreatic carcinomaEpigenetic AlterationsInteraction of Serum microRNAs and Serum Folate With the Susceptibility to Pancreatic Cancer.25084000
Pancreatic Intraductal Papillary Mucinous NeoplasmEpigenetic AlterationsThe epigenetic mechanism of tumorigenesis in pancreatic intraductal papillary mucinous neoplasm (IPMN) remains largely unknown.25084021
Choline Dehydrogenase, MitochondrialEpigenetic AlterationsThe present work provides evidence to support the association of promoter DNA methylation status with the risk profile of CHD.25084356
Breast Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer.25086633
Breast CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) are involved in the progression of breast cancer.25086633
Breast CarcinomaEpigenetic AlterationsSome miRNAs, especially the miR-200 family, miR-9, and miR-155 have been reported to be associated with epithelial-mesenchymal transition (EMT) and breast cancer stem cell (BCSC) phenotypes.25086633
Myeloid Leukemia, ChronicEpigenetic AlterationsTaken together, our findings indicate that LRPPRC is a transcription factor related to ABCB1 expression and highlight the importance of epigenetic regulation in CML resistance.25089713
Clinical Coordinator, Carcinogenesis, Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic alterations of specific genes have been reported to be related to colorectal cancer (CRC) transformation and would also appear to be involved in the early stages of colorectal carcinogenesis.25091577
Multiple MyelomaEpigenetic AlterationsPotential relationship and clinical significance of miRNAs and Th17 cytokines in patients with multiple myeloma.25092124
MICROPHTHALMIA, SYNDROMIC 7Epigenetic AlterationsMiRNA-155 (MiR-155) was found to be upregulated in FLT3-ITD-associated AMLs.25092144
Myeloid Cell Differentiation, Childhood LeukemiaEpigenetic AlterationsMicroRNAs (miRNAs) have a pivotal role in myeloid differentiation and leukemia.25092144
Colorectal Cancer PathwayEpigenetic AlterationsResistant starch fermentation produces butyrate, which can alter microRNA (miRNA) levels in colorectal cancer cells in vitro; effects of red meat and resistant starch on miRNA expression in vivo were unknown.25092886
HepatocarcinogenesisEpigenetic AlterationsHowever, the role of epigenetic changes such as aberrant DNA methylation in hepatocarcinogenesis remains largely unclear.25093504
Adenoma of large intestine, Primary malignant neoplasmEpigenetic AlterationsColorectal adenoma develops into cancer with the accumulation of genetic and epigenetic changes.25093594
Kidney Failure, AcuteEpigenetic AlterationsFollow-up biopsies of AKI allografts compared to time-matched protocol biopsies, further baseline adjustment for zero-hour biopsy expression level and validation in independent datasets, revealed a molecular AKI signature holding 20 mRNAs and two miRNAs (miR-182-5p and miR-21-3p).25093671
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small, noncoding RNAs of endogenous origin that play an important role in tumor development.25095980
Carcinoma of larynxEpigenetic AlterationsExpression and clinical significance of microRNA-152 in supragalottic laryngeal carcinoma.25095980
Metastasis, Primary malignant neoplasmEpigenetic AlterationsCancer is characterized by mutations, genome rearrangements, epigenetic changes, and altered gene expression that enhance cell proliferation, invasion, and metastasis.25100863
Carcinoma of lungEpigenetic AlterationsMicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer.25100863
Chronic Obstructive Airway DiseaseEpigenetic AlterationsPlasma miRNAs might be promising biomarkers of chronic obstructive pulmonary disease.25102970
Chronic Obstructive Airway DiseaseEpigenetic AlterationsHere, we want to find out promising miRNAs for early detection of chronic obstructive pulmonary disease (COPD).25102970
Chronic Obstructive Airway DiseaseEpigenetic AlterationsWe found seven miRNAs were special expression in the COPD patients.25102970
Chronic Obstructive Airway DiseaseEpigenetic AlterationsThese results suggested that plasma miRNAs could be potential specific biomarker for early detection COPD.25102970
Breast CarcinomaEpigenetic AlterationsSerum microRNA-195 is down-regulated in breast cancer: a potential marker for the diagnosis of breast cancer.25103018
NeoplasmsEpigenetic AlterationsMicroRNA-195 (miR-195) is a tumor suppressor that plays an important role in tumorigenesis.25103018
Somatic mutationEpigenetic AlterationsPotential explanations for this relationship include possible autoimmune or estrogen effects of uranium, somatic mutation, epigenetic effects, or effects of some other unidentified accompanying exposure.25103365
Primary malignant neoplasmEpigenetic AlterationsSingle-nucleotide polymorphisms (SNP) in miRNA sequence may alter miRNA functions in gene regulation, which, in turn, may affect cancer risk and disease progression.25103824
Clinical CoordinatorEpigenetic AlterationsHowever, the data on association between miRNA SNPs and CRC development are inconsistent.25103961
Clinical CoordinatorEpigenetic AlterationsOverall, all genotypes and alleles of miRNA SNPs were distributed equally between control and CRC groups.25103961
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have an established role in the development of different cancers.25103961
Primary malignant neoplasmEpigenetic AlterationsMethylenetetrahydrofolate reductase (MTHFR) enzyme is essential for transmethylation reactions including DNA methylation and DNA synthesis and thereby may contribute to cancer prognosis.25104092
Malignant neoplasm of urinary bladderEpigenetic AlterationsmiR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer.25107371
Malignant neoplasm of urinary bladder, Carcinoma of bladderEpigenetic AlterationsOur data indicated that miR-19a might act as an oncogenic microRNA in bladder cancer and was significantly up-regulated in bladder cancer carcinogenesis.25107371
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe discovery of tumor associated miRNAs in serum of patients supported the use of plasma/serum miRNAs as noninvasive means of cancer detection.25107371
Malignant neoplasm of urinary bladderEpigenetic AlterationsHowever, the aberrant expression of miRNAs in bladder cancer patients and their intensive roles and mechanisms in bladder cancer are poorly understood.25107371
Atrial FibrillationEpigenetic AlterationsChronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current.25107449
Cardiac ArrhythmiaEpigenetic AlterationsThese results suggested that this microRNA could participate in the CAF-induced I(Ca,L) downregulation and in the action potential duration shortening that maintains the arrhythmia.25107449
Atrial FibrillationEpigenetic AlterationsAlterations in atrial microRNAs could contribute to the protein changes underlying atrial fibrillation-induced atrial electrical remodeling.25107449
Colorectal Cancer PathwayEpigenetic AlterationsAberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer.25107489
Primary malignant neoplasmEpigenetic AlterationsGlobal DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - A pilot study.25108814
CarcinogenesisEpigenetic AlterationsDNA methylation is a distinctive molecular pathway in colorectal carcinogenesis.25108814
NeoplasmsEpigenetic AlterationsThe significant correlation between pre-treatment DNA methylation with tumour response suggests a potential role for methylation as a biomarker of response.25108814
Primary malignant neoplasmEpigenetic AlterationsAnalysis of DNA epigenetic mutations in the blood circulating DNA is a prospective trend for creation of noninvasive methods for the diagnosis and treatment efficiency monitoring in cancer.25110096
Breast Cancer Cell, NeoplasmsEpigenetic AlterationsMicroRNA-218 (miR-218) is considered a tumor suppressor in human cancer.25110121
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsHigh association between human circulating microRNA-497 and acute myocardial infarction.25110754
Adrenocortical carcinomaEpigenetic AlterationsInhibin alpha-subunit (INHA) expression in adrenocortical cancer is linked to genetic and epigenetic INHA promoter variation.25111790
Glioblastoma Multiforme PathwayEpigenetic AlterationsDownregulation of microRNA-124 predicts poor prognosis in glioma patients.25112530
Loss of Cell Polarity, cervical cancerEpigenetic AlterationsEpigenetic silencing of CXCR4 promotes loss of cell adhesion in cervical cancer.25114911
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsThe microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer.25115396
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOur recent study of microRNA (miRNA) expression signatures in prostate cancer (PCa) has revealed that all members of the miR-23b/27b/24-1 cluster are significantly downregulated in PCa tissues.25115396
MetastasisEpigenetic AlterationsThe cell metabolome comprises abundant information that may be predictive of cell functions in response to epigenetic or genetic changes at different stages of cell proliferation and metastasis.25115443
Esophageal carcinomaEpigenetic AlterationsImplications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis.25117314
Tetranitromethane, Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA was extracted using the Taqman((r)) MicroRNA Assay from 46 EC patients at the same tumor node metastasis (TNM) stage, but with different prognoses, who underwent surgery.25117314
NeoplasmsEpigenetic AlterationsThe tumors of patients with ccRCC had lower expression of miR-126 and miR-378 during the early stages of disease (T1), but higher expression of these miRNAs during the later stages of disease (T2/T3).25119741
Carcinogenesis, Refractory Cytopenia of ChildhoodEpigenetic AlterationsOur results indicate that EphB1 may be involved in carcinogenesis of RCC, the molecular mechanisms of down-regulation of EphB1 including genetic and epigenetic alterations and the dedicated roles of EphB1 in occurrence and progress of RCC need to be explicated in next step.25120806
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small, non-coding RNAs which can function as oncogenes or tumor suppressor genes in human cancers.25120851
Malignant neoplasm of urinary bladder, Transitional cell carcinoma of ureterEpigenetic AlterationsUrothelial cancer associated 1 (UCA1) is a novel non-coding RNA gene, which plays a pivotal role in bladder cancer progression.25123267
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are short non-coding RNAs that exert a critical influence on tumorigenesis through post-transcriptional modification and are considered to be potential biomarkers for the diagnosis or prognosis of various cancers.25124149
Non-Small Cell Lung CarcinomaEpigenetic AlterationsExpression of microRNA miR-126 and miR-200c is associated with prognosis in patients with non-small cell lung cancer.25124149
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAlthough several miRNAs have been proposed as relevant biomarkers for non-small cell lung cancer (NSCLC), detailed working mechanisms and validated prognostic significance of these miRNAs remain controversial.25124149
HIV InfectionsEpigenetic AlterationsThe miRNA pattern of HIV/HCV samples showed altered expression of 57 and 33 miRNA compared to HCV and HIV infection, respectively.25125218
Fibrosis AssessmentEpigenetic AlterationsmiRNA-122 and miRNA-22 were associated with relevant fibrosis (FIB-4 >1.45; APRI >1).25125218
Fibrosis AssessmentEpigenetic AlterationsCirculating levels of miRNA-122 were independent predictors for relevant fibrosis in HIV patients.25125218
Injury of liverEpigenetic AlterationsCirculating miRNA-122, miRNA-22, and miRNA-34a correlates with the etiology of liver injury in HIV patients.25125218
Injury of liver, HIVEpigenetic AlterationsCirculating microRNAs as a marker for liver injury in human immunodeficiency virus patients.25125218
Injury of liverEpigenetic AlterationsMicroRNAs (miRNAs) are small regulatory RNAs suggested as biomarkers for liver injury.25125218
Injury of liverEpigenetic AlterationsWe analyzed the circulating levels of miRNAs in HIV patients with regard to the extent and etiology of liver injury.25125218
Pancreatic carcinomaEpigenetic AlterationsMicroRNA expression in salivary supernatant of patients with pancreatic cancer and its relationship with ZHENG.25126577
Buccal Route of Drug AdministrationEpigenetic AlterationsA quest for miRNA bio-marker: a track back approach from gingivo buccal cancer to two different types of precancers.25126847
Primary malignant neoplasmEpigenetic AlterationsDeregulation of miRNA expression may contribute to tumorigenesis and other patho-physiology associated with cancer.25126847
Oropharyngeal CarcinomaEpigenetic AlterationsA let-7 microRNA polymorphism in the KRAS 3-UTR is prognostic in oropharyngeal cancer.25127693
Patient Satisfaction with Cancer Care QuestionnaireEpigenetic AlterationsOPSCC patients (n=122) were genotyped for ten genetic polymorphisms in pre-miRNAs (pre-mir-146a, pre-mir-196a2), in miRNA biosynthesis genes (Drosha, XPO5) and in miRNA target genes (KRAS, SMC1B).25127693
Ischemic strokeEpigenetic AlterationsmiRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke.25127724
Cerebrovascular accidentEpigenetic AlterationsIn the blood, 287 different miRNAs were detected of which two miRNAs (miR-151a-3p and miR-140-5p) were found upregulated and one miRNA (miR-18b-5p) was found downregulated in the stroke group.25127724
Cerebrovascular accidentEpigenetic AlterationsIn total, 183 different miRNAs were detected in the CSF, of which two miRNAs (let-7c and miR-221-3p) were found upregulated in relation to stroke.25127724
Cerebrovascular accidentEpigenetic AlterationsSome miRNAs occurred exclusively in the CSF including miR-523-3p which was detected in 50 % of the stroke patients, whereas it was completely absent in controls.25127724
nervous system disorderEpigenetic AlterationsOur preliminary results demonstrate that it is possible to detect and profile miRNAs in CSF and blood from patients with neurological diseases.25127724
Cerebrovascular accidentEpigenetic AlterationsSome miRNAs appear differentially expressed in the CSF and others in the blood of stroke patients.25127724
Colorectal CarcinomaEpigenetic AlterationsDownregulation of microRNA-498 in colorectal cancers and its cellular effects.25128149
Perceived stress scaleEpigenetic AlterationsMiR-181a was the miRNA that most profoundly differed between patients with pSS and healthy individuals; however, similar miRNA-181a expression profiles were found in groups with different disease phenotypes.25128511
Virus Diseases, Perceived stress scaleEpigenetic AlterationsIn addition to the regulation of human miRNA, many virus-derived miRNA were unexpectedly upregulated in the patients with pSS, suggesting that viral infection of PBMC plays a role in this disease.25128511
Alzheimers DiseaseEpigenetic AlterationsAlzheimers disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.25129075
Admitting diagnosisEpigenetic AlterationsOur analyses suggest that these DNA methylation changes may have a role in the onset of AD given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network.25129075
Primary malignant neoplasmEpigenetic AlterationsExtracellular microRNAs (miRNAs) embedded in circulating exosomes may serves as prognostic biomarkers in cancer.25129854
Neurodegenerative DisordersEpigenetic AlterationsIn addition, microRNA dysregulation contributes to some mental disorders and neurodegeneration diseases.25130371
Squamous cell carcinoma, Trauma Symptom Checklist for Children QuestionnaireEpigenetic AlterationsHowever, the involvement of microRNA during the EMT process in tongue squamous cell carcinoma (TSCC) remains to be determined.25130698
TGIF1 geneEpigenetic AlterationsEctopic expression of miR-639 with miRNA mimics effectively blocked TGFb-induced EMT in SCC9 and CAL27 cells, but inhibition of miR-639 in SCC9 and CAL27 cells with antisense oligonucleotides induced EMT.25130698
Hepatitis, Hepatitis B, ChronicEpigenetic AlterationsSerum microRNA-124 is a novel biomarker for liver necroinflammation in patients with chronic hepatitis B virus infection.25131617
HepatitisEpigenetic AlterationsThe capacity of serum microRNA-124 levels in discriminating the grade of liver necroinflammation was compared with alanine aminotransferase (ALT) with liver biopsy validation.25131617
HepatitisEpigenetic AlterationsIn patients with normal ALT and a serum HBV DNA load >10(4) copies/mL, receiver operating characteristic (ROC) curve of serum microRNA-124 levels yielded an area under ROC curve (AUC) of 0.840, with 58.3% sensitivity and 91.7% specificity in discriminating between moderate-to-severe liver necroinflammation (G >= 2).25131617
Necrosis with inflammation, HepatitisEpigenetic AlterationsPatients with considerable liver necroinflammation (G >= 2) had significantly higher serum miRNA-124 levels than those without or with mild necroinflammation (P < 0.0001).25131617
Prostatic Cancer, Castration-Resistant, NeoplasmsEpigenetic AlterationsIn a mouse xenograft model of androgen-independent prostate cancer, PAX2 knockdown inhibited tumor growth and AR gene expression and also increased DNA methylation of the AR gene.25132193
Prostatic Cancer, Castration-Resistant, Primary malignant neoplasmEpigenetic AlterationsThese findings suggested that PAX2 promoted cancer cell growth in androgen-independent prostate cancer by regulating AR gene expression through an epigenetic mechanism.25132193
Pancreatic carcinomaEpigenetic AlterationsStromal microRNA-21 levels predict response to 5-fluorouracil in patients with pancreatic cancer.25132574
Primary malignant neoplasm, ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsMicroRNA-21 (miR-21) is upregulated and inversely associated with survival in many cancer types, including pancreatic ductal adenocarcinoma (PDAC).25132574
Secondary malignant neoplasm of prostateEpigenetic AlterationsInfiltrating T cells promote prostate cancer metastasis via modulation of FGF11-miRNA-541-androgen receptor (AR)-MMP9 signaling.25135278
Cell InvasionEpigenetic AlterationsTargeting these newly identified signals via FGF11-siRNA, miRNA-541 inhibitor or MMP9 inhibitor all led to partially reverse the enhanced PCa cell invasion.25135278
MetastasisEpigenetic AlterationsTogether, these results concluded that infiltrating CD4(+) T cells could promote PCa metastasis via modulation of FGF11-miRNA-541-AR-MMP9 signaling.25135278
skeletal muscle plasticityEpigenetic AlterationsEpigenomic regulation of the transcriptome by DNA methylation and posttranscriptional gene silencing by miRNAs are potential environmental modulators of skeletal muscle plasticity to chronic exercise in healthy and diseased populations.25138607
Colorectal Cancer PathwayEpigenetic AlterationsAnalysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer.25139296
Colorectal NeoplasmsEpigenetic AlterationsAberrant DNA methylation could potentially serve as a biomarker for colorectal neoplasms.25139296
Colorectal Cancer PathwayEpigenetic AlterationsOur results demonstrate that DNA methylation in BLF specimens may be a useful biomarker for the detection of colorectal cancer.25139296
Breast CarcinomaEpigenetic AlterationsBreast cancer is a heterogeneous disease with a highly variable clinical outcome in which both genetic and epigenetic changes have critical roles.25139823
Adenocarcinoma of lung (disorder)Epigenetic AlterationsA three-microRNA signature predicts responses to platinum-based doublet chemotherapy in patients with lung adenocarcinoma.25142144
Alzheimers Disease Assessment Scale-Cognitive CDISC Version QuestionnaireEpigenetic AlterationsThe three-miRNA signature in surgically resected primary LADC tissues may by clinically useful for predicting responsiveness to platinum-based doublet chemotherapy in patients with LADC recurrence.25142144
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsAnalysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients.25143946
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroarray technology was used to profile miRNA expression in primary tumor and stromal tissue from paraffin embedded material of 51 patients with colorectal cancer.25143946
Metastasis, NeoplasmsEpigenetic AlterationsNo significant association was found between miRNA expressions and stage at diagnosis, site of primary tumor, first site of metastasis, progression-free, or overall survival.25143946
NeoplasmsEpigenetic Alterations26 miRNAs resulted differentially expressed with at least 2-fold change in tumor tissue with respect to stroma (16 more expressed in the tumor and 10 more expressed in the stroma).25143946
Hormone refractory prostate cancerEpigenetic AlterationsMethylated Glutathione S-transferase 1 (mGSTP1) is a potential plasma free DNA epigenetic marker of prognosis and response to chemotherapy in castrate-resistant prostate cancer.25144624
Primary malignant neoplasmEpigenetic AlterationsmiRNAs are non-coding RNA molecules; their deregulations may contribute to cancer pathogenesis.25146331
Asthma PathwayEpigenetic AlterationsCharacteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.25147914
Asthma PathwayEpigenetic AlterationsEpigenetic changes including DNA methylation caused by environmental exposures may contribute to the heterogeneous inflammatory response in asthma.25147914
Asthma PathwayEpigenetic AlterationsWe have identified characteristic alterations in DNA methylation that are associated with inflammatory phenotypes of asthma and may contribute to the disease mechanisms.25147914
Asthma PathwayEpigenetic AlterationsThis network-based characterization may help in the development of epigenetic biomarkers and therapeutic targets for asthma.25147914
Juvenile Myelomonocytic LeukemiaEpigenetic AlterationsAberrant DNA methylation at specific genetic loci is a key molecular feature of juvenile myelomonocytic leukemia (JMML) with poor prognosis.25147919
Aggressive behaviorEpigenetic AlterationsThe results corroborate the significance of epigenetic modifications in the phenotype of aggressive JMML.25147919
Rheumatoid ArthritisEpigenetic AlterationsGenome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations.25147922
Colorectal Cancer PathwayEpigenetic AlterationsA miRNA-binding site single nucleotide polymorphism in the 3-UTR region of the NOD2 gene is associated with colorectal cancer.25148897
Clinical CoordinatorEpigenetic AlterationsSingle nucleotide polymorphisms in miRNA-binding site on gene transcripts are reported to play important role in increased risk of CRC in different population.25148897
Pancreatic carcinomaEpigenetic AlterationsHere we screened miRNAs associated with drug resistance in pancreatic cancer, and identified a panel of miRNAs dysregulated in gemcitabine-resistance pancreatic cancer cells, including 13 downregulated miRNAs and 20 upregulated miRNAs.25149530
Metastatic hepatocellular carcinomaEpigenetic AlterationsDNA methylation-mediated silencing of matricellular protein dermatopontin promotes hepatocellular carcinoma metastasis by a3b1 integrin-Rho GTPase signaling.25149533
DPT gene, Hollings Cancer CenterEpigenetic AlterationsWe further revealed that the down-regulation of DPT in HCC was due to epigenetic silencing by promoter DNA methylation.25149533
Neoplasms, Neoplasm MetastasisEpigenetic AlterationsOur study provides new evidence for epigenetic control of tumor microenvironment, and suggests matricellular protein DPT may serve as a novel prognostic marker and act as a HCC metastasis suppressor.25149533
Chronic Lymphocytic LeukemiaEpigenetic AlterationsDNA methylation was quantified by highly reproducible bisulfite pyrosequencing assays in two independent CLL series.25151957
Chronic Lymphocytic LeukemiaEpigenetic AlterationsA B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact.25151957
Hematopoietic NeoplasmsEpigenetic AlterationsAberrant expression of CTNNA1 is regulated by epigenetic mechanisms including both promoter methylation and histone deacetylation in hematopoietic malignancies.25153418
melanoma, Primary malignant neoplasmEpigenetic AlterationsIn addition, we integrated our miRNA signature with publicly available Cancer Genome Atlas data to examine the relevance of these miRNAs to melanoma biology.25155861
melanomaEpigenetic AlterationsSerum-based miRNAs in the prediction and detection of recurrence in melanoma patients.25155861
melanomaEpigenetic AlterationsWe recently reported our array-based discovery of prognostic serum miRNAs in melanoma.25155861
melanomaEpigenetic AlterationsData demonstrate that serum miRNAs can improve melanoma patient stratification over stage and support further testing of miR-15b to guide patient surveillance.25155861
Hollings Cancer CenterEpigenetic AlterationsIn HCC, TRb1 down-regulation was not the result of hypermethylation of its promoter, but was associated with an increased expression of TRb1-targeting microRNAs ([miR]-27a, -181a, and -204).25156012
Malignant Head and Neck NeoplasmEpigenetic AlterationsA novel saliva-based microRNA biomarker panel to detect head and neck cancers.25156495
Squamous cell carcinoma of the head and neckEpigenetic AlterationsFive differentially expressed miRNAs were selected from miScript(tm) miRNA microarray data generated using saliva from five HNSCC patients and five healthy controls.25156495
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThis diagnostic panel was independently validated using HNSCC miRNA expression data from The Cancer Genome Atlas (TCGA), encompassing 334 tumours and 39 adjacent normal tissues.25156495
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are known to play an important role in cancer development by post-transcriptionally affecting the expression of critical genes.25156495
Squamous cell carcinoma of the head and neckEpigenetic AlterationsWe found that miR-9 (P <0.0001), miR-134 (P <0.0001) and miR-191 (P <0.001) were differentially expressed between saliva from HNSCC patients and healthy controls, and that these miRNAs provided a good discriminative capacity with area under the curve (AUC) values of 0.85 (P <0.0001), 0.74 (P < 0.001) and 0.98 (P < 0.0001), respectively.25156495
NeoplasmsEpigenetic AlterationsHowever, the exact role of ATM gene and its epigenetic alterations, especially promoter methylation in different grades of brain tumors, remains elusive.25159481
Alzheimers DiseaseEpigenetic AlterationsEpigenetic modifications in Alzheimers disease: cause or effect?25159670
Admitting diagnosisEpigenetic AlterationsThese findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.25159673
NeoplasmsEpigenetic AlterationsDifferences among brain tumor stem cell types and fetal neural stem cells in focal regions of histone modifications and DNA methylation, broad regions of modifications, and bivalent promoters.25163646
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsUsing ChIP-chip and MeDIP-chip approaches, we localized well-established and prevalent epigenetic marks (H3K27me3, H3K4me3, H3K9me3, DNA methylation) on a genome scale in several lines of putative glioma stem cells (brain tumor stem cells, BTSCs) and, for comparison, normal human fetal neural stem cells (fNSCs).25163646
Primary malignant neoplasmEpigenetic AlterationsAberrational epigenetic marks are believed to play a major role in establishing the abnormal features of cancer cells.25163646
Rheumatoid ArthritisEpigenetic AlterationsDecreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis.25164131
Primary malignant neoplasmEpigenetic AlterationsLoss of epigenetic gene regulation through altered long noncoding RNA (lncRNA) expression seems important in human cancer.25165097
Malignant neoplasm of urinary bladderEpigenetic AlterationsIdentification of differentially expressed long noncoding RNAs in bladder cancer.25165097
Stomach Carcinoma, Infection caused by Helicobacter pyloriEpigenetic AlterationsDifferent microRNA expression levels in gastric cancer depending on Helicobacter pylori infection.25167801
Stomach CarcinomaEpigenetic AlterationsmiRNA expression in the intestinal type of H. pylori infection-dependent gastric cancer suggests that different gastric can-cer pathogenesis mechanisms could exist between H. pylori-positive and H. pylori-negative gastric cancer.25167801
Malignant neoplasm of urinary bladderEpigenetic AlterationsUrinary cell-free microRNA-106b as a novel biomarker for detection of bladder cancer.25168920
Malignant NeoplasmsEpigenetic AlterationsExpression of the long non-coding RNA (lncRNA) LOC285194 was previously shown to be correlated with aggressive clinicopathological features and poor prognosis in several cancers.25169763
Stomach CarcinomaEpigenetic AlterationsMicroRNA-218 is upregulated in gastric cancer after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and increases chemosensitivity to cisplatin.25170221
Carcinoma of lung, Malignant neoplasm of lungEpigenetic AlterationsChanges in DNA methylation status have now been identified as a critical component in the initiation of lung cancer, and the detection of DNA methylation is expected to be an important method for the early diagnosis of lung cancer.25172267
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsThese results suggest that epigenetic regulation of CHRNB4 may affect tumor progression and survival in patients with NSCLC.25172267
Squamous cell carcinomaEpigenetic AlterationsCirculating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma.25174622
NeoplasmsEpigenetic AlterationsMicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2.25174799
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsAn increasing body of evidence indicates that miRNAs have a critical role in carcinogenesis and cancer progression; however, the role of miRNAs in the tumorigenesis of adencarcinoma of gastric esophageal junction (AGEJ) remains largely unclear.25174799
Carcinoma of lungEpigenetic AlterationsThe blood-borne miRNA signature of lung cancer patients is independent of histology but influenced by metastases.25175044
Lung NeoplasmsEpigenetic AlterationsWe further determined the overlap of miRNAs expressed in each subgroup with the 24-miRNA signature of lung tumor patients.25175044
Carcinoma of lungEpigenetic AlterationsIn addition, we found a large overlap between the blood-borne miRNAs detected in the three histological subgroups and the previously described 24-miRNA signature that separates lung cancer patients form controls.25175044
Small cell carcinoma of lung, Adenocarcinoma, Squamous cell carcinoma of lung, Hematologic Neoplasms, Non-Small Cell Lung CarcinomaEpigenetic AlterationsThere is a common miRNA expression pattern in blood of lung cancer patients that does not allow a reliable further subtyping into NSCLC or SCLC, or into adenocarcinoma and squamous cell lung cancer.25175044
Carcinoma of lungEpigenetic AlterationsThe previously described 24-miRNA signature for lung cancer appears not primarily dependent on histological subtypes.25175044
Small cell carcinoma of lung, Adenocarcinoma, Squamous cell carcinoma of lungEpigenetic AlterationsBased on a raw p-value < 0.05, only 18 blood-borne miRNAs were differentially expressed between patients with adenocarcinoma and with squamous cell lung carcinoma, 11 miRNAs between adenocarcinoma and SCLC, and 2 between squamous cell lung carcinoma and SCLC.25175044
Small cell carcinoma of lung, Adenocarcinoma, NeoplasmsEpigenetic AlterationsWe identified several miRNAs that allowed differentiating between metastatic and non-metastatic tumors both in blood of patients with adenocarcinoma and in blood of patients with SCLC.25175044
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThere have been many DNA methylation studies on breast cancer which showed various methylation patterns involving tumour suppressor genes and oncogenes but only a few of those studies link the methylation data with gene expression.25175708
Mammary NeoplasmsEpigenetic AlterationsDNA methylation profiling was carried out on 76 fresh frozen primary breast tumour tissues and 25 adjacent non-cancerous breast tissues using the Illumina Infinium((r)) HumanMethylation27 BeadChip.25175708
ovarian neoplasmEpigenetic AlterationsMicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the PI3K/AKT and MAPK/ERK pathways in ovarian cancer.25176450
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) have been shown to play an important role in diverse biological processes and cancer progression.25176450
Primary malignant neoplasmEpigenetic AlterationsSingle-nucleotide polymorphisms in microRNAs play important roles in oncogenesis and cancer development.25177719
Malignant neoplasm of urinary bladder, BehaviorEpigenetic AlterationsMicroRNA-320c inhibits tumorous behaviors of bladder cancer by targeting Cyclin-dependent kinase 6.25178497
Disease, Primary malignant neoplasmEpigenetic AlterationsIncreasing evidence has suggested that dysregulation of microRNAs (miRNAs) could contribute to human disease including cancer.25178497
Colorectal Cancer PathwayEpigenetic AlterationsElevated level of microRNA-21 in the serum of patients with colorectal cancer.25178939
Colorectal Cancer PathwayEpigenetic AlterationsIn patients with colorectal cancer, circulating micro RNA-21 (miR-21) is overexpressed and may act as a potential diagnostic and prognostic biomarker.25178939
Systemic Scleroderma, Sample Size CalculationEpigenetic AlterationsAs aberrant epigenetic modifications have been linked to the pathogenesis of systemic sclerosis (SSc), we aimed to investigate the role of Sirt1 in fibroblast activation.25180292
Asthma PathwayEpigenetic AlterationshASMCs from patients with asthma exhibit elevated expression of cytokine-responsive genes, and in some instances this is attributable to an altered histone code and/or microRNA expression.25180620
Colorectal Cancer PathwayEpigenetic AlterationsA let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy.25183481
hearing impairmentEpigenetic AlterationsEpigenetic regulation might explain the observed difference in age of onset and magnitude of hearing impairment with age.25184702
Coronary ArteriosclerosisEpigenetic AlterationsIn our previous experiments, the altered expressions of circulating miRNA-21-5p, miRNA-361-5p and miRNA-519e-5p were confirmed in patients with coronary atherosclerosis by miRNA microarrays.25184815
Cardiovascular DiseasesEpigenetic AlterationsThe dysregulated expressions of circulating miRNAs have been detected in various cardiovascular diseases.25184815
Acute myocardial infarctionEpigenetic AlterationsHowever, the expression levels of these circulating miRNAs in the early phase of acute myocardial infarction (AMI) are still unknown.25184815
HypoxiaEpigenetic AlterationsFurthermore, cell experiments demonstrated that these plasma miRNAs may originate from injured cardiomyocytes induced by hypoxia.25184815
Pulmonary Embolism, Ischemic strokeEpigenetic AlterationsIn addition, the levels of all the three circulating miRNAs in ischemic stroke (IS) and pulmonary embolism (PE) were elevated, whereas the decreased level of plasma miR-519e-5p was only detected in AMI.25184815
Malignant tumor of colonEpigenetic AlterationsC-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion.25185650
Malignant Neoplasms, Malignant tumor of colonEpigenetic AlterationsRecently, more and more evidence are rapidly accumulating that long noncoding RNAs (lncRNAs) are involved in human tumorigenesis and misregulated in many cancers, including colon cancer.25185650
Multiple MyelomaEpigenetic AlterationsActivation of LTBP3 gene by a long noncoding RNA (lncRNA) MALAT1 transcript in mesenchymal stem cells from multiple myeloma.25187517
NeoplasmsEpigenetic AlterationsLong noncoding RNAs (lncRNAs) are emerging as important regulatory molecules in tumor suppressor and oncogenic pathways.25187517
Myeloid Leukemia, ChronicEpigenetic AlterationsDownregulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: a possible biomarker to discontinue imatinib safely.25187697
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsIdentification of novel genetic and epigenetic alterations is required for optimal stratification of patients with hepatocellular carcinoma (HCC) at risk for recurrence and adverse prognosis.25189544
Primary malignant neoplasmEpigenetic AlterationsAberrant microRNA (miRNA) expression in blood of cancer patients is a common finding.25189899
SERPINB3 wt AlleleEpigenetic AlterationsAlterations in miRNA expression patterns in whole blood of OSCC patients.25189899
SERPINB3 wt AlleleEpigenetic Alterations21 miRNAs were identified to be significantly differentially expressed in whole blood of OSCC patients compared to healthy controls.25189899
SERPINB3 wt AlleleEpigenetic AlterationsThe aberrant expressions of miR-186, miR-494 and miR-3651 in whole blood of OSCC patients may serve as the basis for establishing minimally-invasive screening methods for OSCC based on miRNAs as biomarkers.25189899
NeoplasmsEpigenetic AlterationsMore and more evidence reveals that noncoding RNA miR-34b/c and tumor suppressor gene TP-53 independently, and/or jointly, play crucial roles in carcinogenesis.25190020
Prostate Cancer PathwayEpigenetic AlterationsCirculating miRNAs 21 and 221 as biomarkers for early diagnosis of prostate cancer.25190021
Prostate Cancer PathwayEpigenetic AlterationsOur study showed that serum miRNAs 21 and 221 expression profiling tests may be used as specific noninvasive molecular biomarkers for prostate cancer diagnosis due to their higher sensitivity and specificity with a high negative predictive value leading to a decrease in the biopsies taken for patients with elevated serum PSA values.25190021
Primary malignant neoplasmEpigenetic AlterationsPolymorphisms in pre-microRNAs (miRNAs) or mature miRNAs may influence miRNA processing or target binding, thus contributing to tumorigenesis and cancer development.25190221
Hollings Cancer CenterEpigenetic AlterationsHowever, no significant association between miRNA-608 rs4919510 and the risk of HCC/HBV-associated HCC was found.25190221
Adenocarcinoma of lung (disorder)Epigenetic AlterationsPrognostic significance of microRNA expression in completely resected lung adenocarcinoma and the associated response to erlotinib.25192889
Adenocarcinoma of lung (disorder)Epigenetic AlterationsIn conclusion, lung adenocarcinoma patients with reduced miRNA-21 expression exhibit longer overall survival and a poor response rate to erlotinib.25192889
Refractory Cytopenia of Childhood, Renal Cell Carcinoma PathwayEpigenetic AlterationsData mining using a microRNA array database suggested that let-7d microRNA may be associated with renal cell carcinoma (RCC) malignant progression.25193015
Prostate Cancer PathwayEpigenetic AlterationsDNA methylation gene-based models indicating independent poor outcome in prostate cancer.25193387
Primary malignant neoplasmEpigenetic AlterationsDNA methylation plays an important role in determining the biology of cancer but prognostic information is scanty.25193387
Prostate Cancer Pathway, Cessation of lifeEpigenetic AlterationsWe assessed the potential of gene-specific DNA methylation changes to predict death from prostate cancer in a cohort of untreated men in the UK.25193387
Colorectal Cancer Pathway, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsRecently, microRNA-339-5p has been reported to be frequently down-regulated in colorectal cancer, and furthermore, its down-regulation is associated with poor prognosis in cancer patients, which strongly suggests a tumor suppressive function of microRNA-339-5p in colorectal cancer.25193859
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsFurthermore, microRNA-339-5p inhibits the migration and invasion of colorectal cancer cells and the growth of colorectal xenograft tumors in a largely p53-dependent manner.25193859
Colorectal Neoplasms, NeoplasmsEpigenetic AlterationsOur results highlighted an important role of microRNA-339-5p in suppression of colorectal tumorigenesis, and also revealed that regulating the p53 function is an important mechanism for microRNA-339-5p in tumor suppression.25193859
GlioblastomaEpigenetic AlterationsEpigenetic silencing of MGMT is associated with loss of MGMT activity and improved sensitivity to alkylating agents in glioblastomas.25194640
ovarian neoplasmEpigenetic AlterationsA polymorphism at miRNA-122-binding site in the IL-1a 3UTR is associated with risk of epithelial ovarian cancer.25195148
Nasopharyngeal carcinomaEpigenetic AlterationsEpigenetic markers for noninvasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting.25196065
Carcinogenesis, NeoplasmsEpigenetic AlterationsSince aberrant promoter hypermethylation of tumor suppressor genes (TSGs) is widely considered to be an important epigenetic change in early carcinogenesis, this study identified a panel of methylation markers for early detection of NPC and also assessed the clinical usefulness of these markers with noninvasive plasma specimens instead of biopsies.25196065
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNAs (miRNAs) are involved in numerous biological and pathological processes including colorectal cancer (CRC).25197016
Coronary Artery DiseaseEpigenetic AlterationsPolymorphism in miRNA-1 target site and circulating miRNA-1 phenotype are associated with the decreased risk and prognosis of coronary artery disease.25197382
Malignant NeoplasmsEpigenetic AlterationsLin28B, a homologue of Lin28, represses biogenesis of let-7 microRNAs with a role in tumorigenesis and is considered a potential therapeutic target for various human cancers.25197381
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-133a has been proven downregulated in many human malignancies and correlated with tumor progression.25198665
Coronary Artery DiseaseEpigenetic AlterationsAltered serum microRNAs as novel diagnostic biomarkers for atypical coronary artery disease.25198728
Inflammation, Fibrosis AssessmentEpigenetic AlterationsIn addition, target gene prediction showed that these five altered miRNAs are involved in affecting various aspects of cardiac or vascular remodeling, especially in the pathway involving inflammation and fibrosis.25198728
Arteriosclerosis, Coronary ArteriosclerosisEpigenetic AlterationsOur findings indicate that the five altered serum miRNAs could be novel non-invasive biomarkers for ACAD and may also represent potential therapeutic targets for atherosclerosis and myocardial ischemia.25198728
Stage II Colon Cancer AJCC v7Epigenetic AlterationsThe prognostic value of microRNA-126 and microvessel density in patients with stage II colon cancer: results from a population cohort.25199818
Malignant tumor of colonEpigenetic AlterationsWe analysed the prognostic value of two angiogenesis parameters, microRNA-126 (miRNA-126) and microvessel density (MVD), in a population based cohort of patients operated for stage II colon cancer.25199818
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsLong non-coding RNAs expressed in pancreatic ductal adenocarcinoma and lncRNA BC008363 an independent prognostic factor in PDAC.25200694
ovarian neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) play critical roles in the development and progression of ovarian cancer.25201063
Aortic Aneurysm, AbdominalEpigenetic AlterationsNotably, plasma levels of miR-195 were reduced in patients with abdominal aortic aneurysms suggesting that microRNAs might serve as a noninvasive biomarker of abdominal aortic aneurysms.25201911
NeoplasmsEpigenetic AlterationsHistone deacetylase (HDAC) is well-known to be associated with tumorigenesis through epigenetic regulation and its inhibitors (HDACIs) induce differentiation and apoptosis of tumor cells.25202113
Stomach CarcinomaEpigenetic AlterationsAssociation between common genetic variants in pre-microRNAs and prognosis of advanced gastric cancer treated with chemotherapy.25202115
Malignant NeoplasmsEpigenetic AlterationsCommon single-nucleotide polymorphisms (SNPs) in pre-miRNAs (hsa-mir-196a2, hsa-mir-146a and hsa-mir-499) have been associated with various malignancies and their prognoses.25202115
Degenerative polyarthritisEpigenetic AlterationsEpigenetic differences in human cartilage between mild and severe OA.25212754
Degenerative polyarthritisEpigenetic AlterationsThe development of osteoarthritis (OA) depends on genetic and environmental factors, which influence the biology of the chondrocyte via epigenetic regulation.25212754
Malignant NeoplasmsEpigenetic AlterationsChanges in DNA methylation in peripheral blood could be associated with malignancy at early stage.25213452
Nasopharyngeal carcinomaEpigenetic AlterationsCirculating Epstein-Barr virus microRNAs miR-BART7 and miR-BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment.25213622
NeoplasmsEpigenetic AlterationsNPC is an Epstein-Barr virus (EBV) associated tumor in which only a few viral proteins but more than 20 BamHI A rightward transcripts (BART) microRNAs are detected, at abundant levels.25213622
Myeloid Leukemia, ChronicEpigenetic AlterationsThe epigenetic silencing of miR-23a led to derepression of BCR/ABL expression, and consequently contributes to CML development and progression.25213664
NeoplasmsEpigenetic AlterationsMicroRNA (miR) 149 functions as a tumor suppressor and plays an important role in the carcinogenesis of renal cells.25213695
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-10b indicates a poor prognosis of non-small cell lung cancer and targets E-cadherin.25214146
Metastasis, Primary malignant neoplasmEpigenetic AlterationsMicroRNA-10b(miR-10b) has been reported to be dysregulated in some types of cancer and to play an important role in invasion and metastasis.25214146
Idiopathic Pulmonary FibrosisEpigenetic AlterationsLung fibroblasts from patients with idiopathic pulmonary fibrosis exhibit genome-wide differences in DNA methylation compared to fibroblasts from nonfibrotic lung.25215577
Idiopathic Pulmonary FibrosisEpigenetic AlterationsDNA methylation changes are critical to the development of many diseases, but the DNA methylome of IPF fibroblasts has never been characterized.25215577
Idiopathic Pulmonary FibrosisEpigenetic AlterationsDNA methylation differences may thus help to explain a proportion of the differences in gene expression previously observed in studies of IPF fibroblasts.25215577
Idiopathic Pulmonary FibrosisEpigenetic AlterationsMoreover, significant variability in DNA methylation was observed among individual IPF cell lines, suggesting that differences in DNA methylation may contribute to fibroblast heterogeneity among patients with IPF.25215577
Idiopathic Pulmonary FibrosisEpigenetic AlterationsThese results demonstrate that IPF fibroblasts exhibit global differences in DNA methylation that may contribute to the excessive fibroproliferation associated with this disease.25215577
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsPlasma circulating-microRNA profiles are useful for assessing prognosis in patients with cytogenetically normal myelodysplastic syndromes.25216221
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsWe applied a novel, high-throughput digital quantification technology (NanoString) to profile microRNA expression in plasma samples of 72 patients with myelodysplastic syndromes and 12 healthy individuals.25216221
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsIn patients with myelodysplastic syndromes associated with a diploid karyotype, we identified and validated a 7-microRNA signature as an independent predictor of survival with a predictive power of 75% accuracy (P=0.008), better than those of the International Prognostic Scoring Systems and the MD Anderson Prognostic Lower Risk Prognostic Model.25216221
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsThese results validate the utility of circulating-microRNA levels as noninvasive biomarkers that can inform the management of patients with myelodysplastic syndromes.25216221
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsWe also identified differentially expressed plasma microRNAs in patients with myelodysplastic syndromes versus healthy individuals and between patients with myelodysplastic syndromes associated with different cytogenetic features.25216221
Barrett EsophagusEpigenetic AlterationsTranscribed ultraconserved noncoding RNAs (T-UCR) are involved in Barretts esophagus carcinogenesis.25216530
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsDysregulation of miRNA expression plays an important role in cancer development, and circulating miRNAs are biomarkers of several cancers.25216866
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsElevated microRNA-185 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in clear cell renal cell carcinoma.25217984
NeoplasmsEpigenetic AlterationsTumors were classified as low or high miRNA-185-expressing using the median as the cutoff.25217984
NeoplasmsEpigenetic AlterationsThe median gene expression levels of VEGFR-2 were significantly lower in the tumors expressing low levels of miRNA-185, 0.31 (95 % CI, 0.25-0.37), compared to those expressing high levels of miRNA-185, 0.47 (95 % CI, 0.27-0.59), p = 0.02.25217984
NeoplasmsEpigenetic AlterationsThe median MVD was significantly lower in the tumors expressing low levels of miRNA-185, 6.8 (95 % CI, 6.33-7.67), compared to those expressing high levels, 8.0 (95 % CI, 6.33-9.00), p < 0.01. miRNA-185 was detected in endothelial cells by in situ hybridization detection.25217984
Refractory Cytopenia of ChildhoodEpigenetic AlterationsThe results suggest that high levels of miRNA-185 in RCC are associated with high VEGFR-2 mRNA and protein levels and a higher density of microvessels.25217984
Refractory Cytopenia of ChildhoodEpigenetic AlterationsHowever, further investigation should be performed to analyze the prognostic value of miRNA-185 in RCC.25217984
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are involved in a number of biological processes, including tumor biology.25217984
Vulvar NeoplasmsEpigenetic AlterationsHPV16 DNA methylation, integration and gene expression were assessed using pyrosequencing, ligation-mediated PCR and QPCR, in biopsies from 25 patients attending a specialist vulval neoplasia clinic and in short-term clonal cell lines derived from vulval and vaginal neoplasia.25218242
Human Papillomavirus PositiveEpigenetic AlterationsThe data suggest that increased HPV DNA methylation may be partly attributable to viral integration, and provide a biological rationale for quantification of L1/L2 methylation in triage of HPV positive cervical screening samples.25218242
Malignant neoplasm of stomach, NeoplasmsEpigenetic AlterationsMicroRNA-106b~25 expressions in tumor tissues and plasma of patients with gastric cancers.25218271
Tetranitromethane, Metastasis, NeoplasmsEpigenetic AlterationsThe expression of miRNA-106b~25 cluster in tumor tissues was significantly correlated with tumor size, borrmann type, depth of tumor invasion (T), lymph node metastases (N), distant metastasis (M) and TNM stage (P<0.05).25218271
Tetranitromethane, Stomach Carcinoma, NeoplasmsEpigenetic AlterationsConsidering the relationship between three miRNAs and some clinical pathological factors (TNM stage), it was implied that miR-106b~25 could be the next potential tumor biomarker for diagnosis and predictive prognosis for gastric cancer patients.25218271
Squamous cell carcinoma of esophagusEpigenetic AlterationsPrognostic value of microRNA-100 in esophageal squamous cell carcinoma.25218280
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsMicroRNA-100 (miR-100) has been demonstrated to be implicated in tumorigenesis and tumor progression of human esophageal squamous cell carcinoma (ESCC).25218280
Primary malignant neoplasm, Leukemia, Myelocytic, AcuteEpigenetic AlterationsIn silico analysis of DNA methylation data for 173 AML samples generated by the Cancer Genome Atlas Research Network revealed promoter hypermethylation of the gene encoding Y box binding protein 3, YBX3, in 11/173 (6.4%) AML cases, which was significantly associated with reduced mRNA expression (P < 0.0001).25220401
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia.25220401
Hematologic NeoplasmsEpigenetic AlterationsAlthough aberrant epigenetic changes are frequently implicated in blood cancers, their direct role in suppressing one or both alleles of critical splicing factors has not been previously examined.25220401
Morular Metaplasia of the EndometriumEpigenetic AlterationsSerum miRNA levels were analyzed in 108 newly diagnosed symptomatic MM patients and 56 healthy donors (HDs).25220540
Primary malignant neoplasmEpigenetic AlterationsIt is increasingly apparent that cancer development depends not only on genetic alterations, but also on epigenetic changes involving histone modifications.25220908
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are thought to play a role in cancer development.25222224
Malignant NeoplasmsEpigenetic AlterationsPolymorphisms in pri-, pre-, and mature-microRNAs (miRNAs) have been proposed to be associated with various human cancers.25222241
Breast CarcinomaEpigenetic AlterationsEpigenetic test for breast cancer.25225690
MetastasisEpigenetic AlterationsThus, miR-506 represents a new class of miRNA that regulates both E-cad and vimentin/N-cad in the suppression of EMT and metastasis.25230372
Liver carcinoma, NeoplasmsEpigenetic AlterationsmiR-1285-3p acts as a potential tumor suppressor miRNA via downregulating JUN expression in hepatocellular carcinoma.25230788
Osteopenia, OsteoporosisEpigenetic AlterationsWe have demonstrated that specific miRNAs species are significantly changed in the plasma of osteoporosis and osteopenia patients and correlated with the BMD.25231354
Primary malignant neoplasmEpigenetic AlterationsEmerging evidence suggests that altered expression of microRNAs (miRNAs) is involved in cancer progression.25231560
Ulcerative ColitisEpigenetic AlterationsThe identification of differentially expressed miRNAs, IL-37, and IRAK-M suggests different pathophysiologic mechanisms in various disease stages in LC, CC, and UC.25232259
Colorectal Traditional Serrated AdenomaEpigenetic AlterationsMicroRNA-31 expression in colorectal serrated pathway progression.25232271
Clinical CoordinatorEpigenetic AlterationsWe have recently observed that microRNA-31 (miR-31) expression is associated with BRAF mutation and prognosis in CRC.25232271
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsMicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers (CRC).25232271
Colorectal CarcinomaEpigenetic AlterationsmicroRNA-221 and microRNA-18a identification in stool as potential biomarkers for the non-invasive diagnosis of colorectal carcinoma.25233396
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsThe detection of microRNA (miRNA) dysregulation in stool is a novel approach for the diagnosis of colorectal carcinoma (CRC).25233396
Clinical CoordinatorEpigenetic AlterationsA miRNA expression array containing 667 miRNAs was performed to identify miRNA dysregulation in CRC tissues.25233396
Clinical CoordinatorEpigenetic AlterationsWe focused on miR-221 and miR-18a, two significantly upregulated miRNAs which were subsequently verified in 40 pairs of CRC tissues and 595 stool samples (198 CRCs, 199 polyps and 198 normal controls).25233396
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsMicroRNA-196 (miR-196), which is highly up-regulated in oral cancer cells, has been reported to be aberrantly expressed in several cancers; however, the significance of miR-196 in oral cancer has not yet been addressed.25233933
Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease, MyelofibrosisEpigenetic AlterationsOverexpression of high mobility group AT-hook 2 (Hmga2), which is negatively regulated by MIRLET7 micro RNAs through 3-untranslated region (3UTR), causes proliferative haematopoiesis mimicking myeloproliferative neoplasms (MPNs) and contributes to progression of myelofibrosis in mice.25236537
Primary malignant neoplasmEpigenetic AlterationsThe targets of four down-regulated miRNAs in MPM (mir-181a-5p, miR-101-3p, miR-145-5p and miR-212-3p), one in PP (mir-101-3p) and one in HP (mir-494) were significantly enriched in "pathways in cancer".25236577
Serous Cystadenocarcinoma, Adenocarcinoma, Clear CellEpigenetic AlterationsTo identify microRNA profiles specific for clear cell carcinomas, microRNA expression profiles were compared between clear cell carcinomas and serous carcinomas of the ovary using microRNA microarray.25238166
Adenocarcinoma, Clear Cell, NeoplasmsEpigenetic AlterationsWhen germ cell tumors were compared with clear cell carcinomas of the ovary, miR-302d was the most significantly overexpressed microRNA in germ cell tumors.25238166
Endometrial Clear Cell AdenocarcinomaEpigenetic AlterationsThus, here we describe microRNA profiles characteristic for clear cell carcinomas of the ovary and uterus.25238166
Ovarian Clear Cell Tumor, Serous Cystadenocarcinoma, Adenocarcinoma, Clear Cell, Carcinoma, EndometrioidEpigenetic AlterationsSix microRNAs differentially expressed between ovarian clear cell and serous carcinomas distinguished uterine clear cell carcinomas from endometrioid carcinomas.25238166
InflammationEpigenetic AlterationsDifferential expression and correlations between miRNAs, genes of the TLR pathways, and clinical parameters are unique findings in the severely injured and may lead to a greater understanding of the regulation of sterile inflammation after severe injury.25239329
Colorectal Cancer PathwayEpigenetic AlterationsClinical potential role of circulating microRNAs in early diagnosis of colorectal cancer patients.25239640
Clinical CoordinatorEpigenetic AlterationsCirculating microRNAs (miRNAs) are promising molecular markers for CRC prediction.25239640
Clinical CoordinatorEpigenetic AlterationsWe performed a comprehensive meta-analysis to integrate an evaluation index for diagnostic accuracy of circulating miRNAs in diagnosing CRC patients.25239640
InsulatorEpigenetic AlterationsSubsequent investigations indicate that long intergenic non-coding RNA lincRNA-NR_034037, separating TSNAX from DISC1, regulates TSNAX -DISC1 production and TSNAX/DISC1 expression levels by extricating CTCF from insulators.25239642
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsThe deregulation of microRNAs has been reported to play a pivotal role in hepatocellular carcinoma (HCC).25240815
Metastasis, Primary malignant neoplasmEpigenetic AlterationsUbiquitin-specific protease 22 (USP22) is a component of the transcription regulatory histone acetylation complex SAGA, which broadly regulates gene transcription and correlates with cancer progression, metastasis and prognosis.25241857
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) are novel transcripts that may play important roles in cancer.25243407
Colorectal Cancer PathwayEpigenetic AlterationsPrognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer.25243792
NeoplasmsEpigenetic AlterationsNumerous changes in epigenetic mechanisms have been described in various types of tumors.25243792
Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic inactivation and tumor-suppressor behavior of NGFR in human colorectal cancer.25244921
Blood ClotEpigenetic AlterationsA panel of microRNAs as a new biomarkers for the detection of deep vein thrombosis.25244974
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmicroRNA-548l is involved in the migration and invasion of non-small cell lung cancer by targeting the AKT1 signaling pathway.25245053
Primary malignant neoplasmEpigenetic AlterationsmicroRNAs (miRNAs) have been documented playing a critical role in cancer development and progression.25245053
Primary malignant neoplasmEpigenetic AlterationsSeveral miRNAs are differentially expressed in cancer and many are being considered as biomarkers for predicting clinical outcomes.25252191
Colorectal Cancer PathwayEpigenetic AlterationsThe expression of microRNA-375 in plasma and tissue is matched in human colorectal cancer.25255814
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) offer great potential as cancer biomarkers.25255814
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsThe importance of miRNAs profiling in tissue and body fluids in colorectal cancer (CRC) have been addressed respectively in many studies.25255814
Cardiovascular DiseasesEpigenetic AlterationsMicroRNAs (miRNAs) are associated with cardiovascular disease and control gene expression and are detectable in the circulation.25257092
Neoplasms, Leukemia, Myelocytic, AcuteEpigenetic AlterationsSMG1 acts as a novel potential tumor suppressor with epigenetic inactivation in acute myeloid leukemia.25257528
Neoplasms, Leukemia, Myelocytic, AcuteEpigenetic AlterationsIn conclusion, our results indicate that SMG1 acts as a potential tumor suppressor with epigenetic regulation in AML.25257528
NeoplasmsEpigenetic AlterationsAt the molecular level, non-coding RNAs and especially microRNAs have played an important role in the origin and development of this neoplasm In the Anglo-Saxon population, diverse genetic variants in microRNA genes and in their targets are associated with the development of this disease.25259427
Breast CarcinomaEpigenetic Alterations[Genetic variants in miRNAs and its association with breast cancer].25259427
Stomach CarcinomaEpigenetic AlterationsThe novel long noncoding RNA AC138128.1 may be a predictive biomarker in gastric cancer.25260808
CarcinogenesisEpigenetic AlterationsIt is well known that the differential expression of long noncoding RNA (lncRNA) plays critical roles in carcinogenesis.25260808
Primary malignant neoplasmEpigenetic AlterationsIdentification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer.25261372
Primary malignant neoplasmEpigenetic AlterationsExpression of miR-155 was detected and quantitated in rectal cancer tissues and in adjacent nonmalignant tissues from 40 patients by TaqMan MicroRNA assays.25261908
Primary malignant neoplasmEpigenetic AlterationsRecently identified class of microRNAs (miRNAs) provided a new insight in cancer research.25261908
NeoplasmsEpigenetic AlterationsAs a member of miRNAs family, miR-155 expression demonstrated the correlation with tumor stage.25261908
Primary malignant neoplasmEpigenetic AlterationsEnhancer of zeste homolog 2 (EZH2) plays a key role in tumorigenesis and cancer progression through epigenetic gene silencing and chromatin remodeling.25262426
Radiation-Induced CancerEpigenetic AlterationsRadiation-induced changes in DNA methylation and their relationship to chromosome aberrations in nuclear power plant workers.25264146
Carcinoma, Adrenal Cortical AdenomaEpigenetic AlterationsSpecific MicroRNAs Differentiate Adrenocortical Adenomas from Carcinomas and Correlate With Weiss Histopathologic System.25265426
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRs) play a central role in regulating gene expression and are strongly associated with cancer development.25265426
SepticemiaEpigenetic AlterationsDysregulation in microRNA expression in peripheral blood mononuclear cells of sepsis patients is associated with immunopathology.25265569
Kaposi SarcomaEpigenetic AlterationsThe expression profiles of microRNAs in Kaposis sarcoma.25266797
Cessation of lifeEpigenetic AlterationsMicroRNAs are non-protein-coding small RNAs in the size range 19-25 nucleotides (nt) that play important roles in biological processes, including cellular differentiation, proliferation, and death.25266797
Squamous cell carcinomaEpigenetic AlterationsExpression of microRNA-10a-5p was down-regulated in LEPL, showing statistical difference between low-risk lesion group and high-risk lesion group, while microRNA-34c-5p expression was up-regulated gradually in LEPL groups and dropped suddenly in squamous cell carcinoma group.25266939
Malignant NeoplasmsEpigenetic AlterationsDysregulation of microRNA plays critical roles in various malignancies.25270284
Liver neoplasmsEpigenetic AlterationsIn summary, a senescence-inducing program was found in hepatocytes with increased b-catenin levels and a positive selection of hepatocytes lacking p16(INK4a), by epigenetic silencing, drives the development of liver tumors in mice with reduced APC expression (Apc(580S) mice).25270420
Liver neoplasmsEpigenetic AlterationsEpigenetic silencing of p16(Ink4a) in selected liver cells bypassing senescence is a general principle for development of liver tumors with b-catenin involvement in mice independent of the initial stimulus.25270420
Breast Cancer CellEpigenetic AlterationsUpregulation of miRNA-494 (miR-494) has been identified as an oncogenic miRNA and is associated with poor prognosis in several types of human cancer.25270723
Primary malignant neoplasmEpigenetic AlterationsAccumulating evidence has shown that micro-RNAs (miRNAs) are involved in multiple processes in cancer development and progression.25270723
Stomach CarcinomaEpigenetic AlterationsEpigenetic silencing of miRNA-9 is correlated with promoter-proximal CpG island hypermethylation in gastric cancer in vitro and in vivo.25270964
NeoplasmsEpigenetic AlterationsHere, we examine if tumor suppressor microRNAs (miRNAs) are silenced in a similar manner.25270964
Carcinoma, MetastasisEpigenetic AlterationsThree other miRNAs, miR-19b, miR-433, and miR-370 were associated with lymph node metastasis, decreased curvature, and poorly differentiated carcinoma.25270964
Malignant neoplasm of urinary bladderEpigenetic AlterationsUpregulated UHRF1 promotes bladder cancer cell invasion by epigenetic silencing of KiSS1.25272010
Primary malignant neoplasmEpigenetic AlterationsUbiquitin-like with PHD and RING finger domains 1 (UHRF1), as an epigenetic regulator, plays important roles in the tumorigenesis and cancer progression.25272010
Malignant Neoplasms, Metastasis, Primary malignant neoplasmEpigenetic AlterationsKiSS1 functions as a metastasis suppressor in various cancers, and epigenetic silencing of KiSS1 increases the metastatic potential of cancer cells.25272010
Malignant neoplasm of urinary bladderEpigenetic AlterationsThese data demonstrated that upregulated UHRF1 increases bladder cancer cell invasion by epigenetic silencing of KiSS1.25272010
Primary malignant neoplasmEpigenetic AlterationsAltogether, our data indicate that epigenetic activation of rDNA genes induced by JHDM1B depletion is associated with a p53-dependent growth arrest, but may promote cancer cell growth when p53 is lacking.25273595
Breast CarcinomaEpigenetic AlterationsWild-type genotypes of BRCA1 gene SNPs combined with micro-RNA over-expression in mammary tissue leading to familial breast cancer with an increased risk of distant metastases occurrence.25273865
Stomach CarcinomaEpigenetic AlterationsDNA methylation at selected CpG sites in peripheral blood leukocytes is predictive of gastric cancer.25275032
Neoplasm MetastasisEpigenetic AlterationsMicroRNAs (miRNAs) are small, non-coding RNA molecules involved in post-transcriptional gene regulation and have recently been shown to play a role in cancer metastasis.25277099
Secondary malignant neoplasm of female breastEpigenetic AlterationsMicroRNA expression as risk biomarker of breast cancer metastasis: a pilot retrospective case-cohort study.25277099
Breast Carcinoma, Metastasis, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsIn solid tumors, especially breast cancer, alterations in miRNA expression contribute to cancer pathogenesis, including metastasis.25277099
Breast Carcinoma, MetastasisEpigenetic AlterationsConsidering the emerging role of miRNAs in metastasis, the identification of predictive markers is necessary to further the understanding of stage-specific breast cancer development.25277099
MetastasisEpigenetic AlterationsAmong these, we identified miRNAs previously associated with cell motility (let-7 family) and distant metastasis (hsa-miR-21).25277099
MIR183 wt AlleleEpigenetic AlterationsBetween them, hsa-miR-183 was the most significative of CSII, which miRNAs combination for CSII (hsa-miR-494, hsa-miR-183 and hsa-miR-21) was significant and were a more effective risk marker compared to the single miRNAs.25277099
Secondary malignant neoplasm of female breastEpigenetic AlterationsThese miRNAs therefore represent new risk biomarkers of breast cancer metastasis and may be useful for future targeted therapies.25277099
Carcinoma of lung, AdenocarcinomaEpigenetic AlterationsGenome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome.25278450
Carcinoma of lungEpigenetic AlterationsHowever, whether clinically relevant subgroups based on DNA methylation patterns exist in lung cancer remains unclear.25278450
AdenocarcinomaEpigenetic AlterationsUnsupervised bootstrap clustering was performed to identify DNA methylation subgroups, which were validated in 695 adenocarcinomas and 122 SqCCs.25278450
Carcinoma of lung, Adenocarcinoma, NeoplasmsEpigenetic AlterationsThis study demonstrates the possibility to further subgroup lung cancer, and more specifically adenocarcinomas, based on epigenetic/molecular classification that could lead to more accurate tumor classification, prognostication, and tailored patient therapy.25278450
GliomaEpigenetic AlterationsA miRNA signature for defining aggressive phenotype and prognosis in gliomas.25279461
Colonic NeoplasmsEpigenetic AlterationsThe prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas (TCGA) datasets.25279461
Glioma, NeoplasmsEpigenetic AlterationsWe identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.25279461
Glioblastoma, Glioblastoma Multiforme PathwayEpigenetic AlterationsOur results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.25279461
Stomach Carcinoma, MetastasisEpigenetic AlterationsMetastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis.25280565
Somatic, ovarian neoplasm, BRCA1 geneEpigenetic AlterationsThe performance of BRCA1 immunohistochemistry for detecting germline, somatic, and epigenetic BRCA1 loss in high-grade serous ovarian cancer.25281711
ovarian neoplasm, BRCA1 geneEpigenetic AlterationsGiven the potential importance of BRCA1 loss as a predictive and prognostic biomarker in high-grade serous ovarian cancer, we sought to evaluate the utility of BRCA1 immunohistochemistry (IHC) in screening for BRCA1 loss by germline, somatic, and epigenetic mechanisms.25281711
Somatic, BRCA1 geneEpigenetic AlterationsBRCA1 IHC interpretation was a highly reproducible and accurate modality for detecting germline, somatic, or epigenetic mechanisms of BRCA1 loss.25281711
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsGene promoter hypermethylation is recognised as an essential early step in carcinogenesis, indicating important application areas for DNA methylation analysis in early cancer detection.25281766
Malignant neoplasm of endometrium, cervical cancer, Histologic typeEpigenetic AlterationsAll samples of women with cervical cancer (79/79, 100%), independent of the histotype, and 76% (16/21; 95% CI 58.0% to 94.4%) of women with endometrial cancer scored positive for DNA methylation for at least one of the three genes.25281766
Breast CarcinomaEpigenetic AlterationsMicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9.25281924
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsmiR-3127-5p is a primate-specific miRNA which is down-regulated in recurrent NSCLC tissue vs. matched primary tumor tissue (N = 15) and in tumor tissue vs. normal lung tissue (N = 177).25284075
palladium, Parkinson DiseaseEpigenetic AlterationsThe deregulation of several microRNAs (miRNAs) has been associated with neurodegenerative processes, including Parkinsons disease (PD).25284245
Clinical Coordinator, AdenomaEpigenetic AlterationsWe selected 7 miRNA candidates with previously reported elevated expression in adenoma tissue but low expression in blood cells ("rare" miRNAs), 2 previously proposed as adenoma biomarkers, and 3 implicated in CRC.25286412
Clinical CoordinatorEpigenetic AlterationsStrong (ORs >5) and significant associations with CRC were observed for 6 miRNA candidates, with corresponding AUCs significantly >0.5.25286412
Colorectal NeoplasmsEpigenetic AlterationsRare circulating microRNAs as biomarkers of colorectal neoplasia.25286412
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNAs (miRNAs) are regulatory RNAs, stable in circulation, and implicated in colorectal cancer (CRC) etiology and progression.25286412
Colorectal NeoplasmsEpigenetic AlterationsHowever, many circulating miRNAs are highly expressed in blood cells, and therefore may not be specific to colorectal neoplasia.25286412
AdenomaEpigenetic AlterationsNo miRNAs were significantly associated with non-advanced or advanced adenomas.25286412
AdenomaEpigenetic AlterationsThese candidate miRNAs, assayed by qRT-PCR, are probably unsuitable as blood-based adenoma biomarkers.25286412
Clinical CoordinatorEpigenetic AlterationsStrong associations between miRNAs and CRC were observed, but primarily with miRNAs highly expressed in blood cells.25286412
AdenomaEpigenetic AlterationsThese results suggest that rare miRNAs will require new detection methods to serve as circulating biomarkers of adenomas.25286412
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsDNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival.25287138
Breast Carcinoma, NeoplasmsEpigenetic AlterationsHowever, the role of DNA methylation in breast cancer development and progression and its relationship with the intrinsic tumor subtypes are not fully understood.25287138
NeoplasmsEpigenetic AlterationsThis study demonstrates that epigenetic patterns are strongly associated with HR status, subtype, and p53 mutation status and may show heterogeneity within tumor subclass.25287138
Acute Cerebrovascular AccidentsEpigenetic AlterationsCirculating microRNAs as novel potential biomarkers for early diagnosis of acute stroke in humans.25287657
Acute Cerebrovascular AccidentsEpigenetic AlterationsThe significance of circulating miRNAs for early diagnosis of acute stroke in humans is unknown.25287657
MIR106B gene, Acute Cerebrovascular AccidentsEpigenetic AlterationsCompared with healthy individuals, the miRNAs were increased as in patients with acute stroke as follows: hsa-miR-106b-5P, 3.63-fold in MRI(-) patients and 23.90-fold in MRI(+) patients; hsa-miR-4306, 3.19-fold in MRI(-) patients and 5.30-fold in MRI(+) patients; hsa-miR-320e, .33-fold in MRI(-) patients and .13-fold in MRI(+) patients; and hsa-miR-320d, .23-fold in MRI(-) patients and .07-fold in MRI(+) patients.25287657
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsGenome-wide miRNA profiling in myelodysplastic syndrome with del(5q) treated with lenalidomide.25287904
SF3B1 wt AlleleEpigenetic AlterationsThis report describes changes in miRNA expression in del(5q) patients with MDS treated with lenalidomide, likely arising from deregulation of pathways implicated in lenalidomide action.25287904
HaploinsufficiencyEpigenetic AlterationsAdditionally, we focused more deeply on miRNAs from the 5q commonly deleted region and found that levels of miR-378 and miR-378* followed haploinsufficiency trend.25287904
Pituitary Neoplasms, MetastasisEpigenetic AlterationsHowever, the molecular mechanism of these miRNAs in pituitary tumor growth and metastasis is still unclear.25305447
Pituitary NeoplasmsEpigenetic AlterationsThen, we show that these miRNAs synergistically target Sox5 in pituitary tumor.25305447
Pituitary Neoplasms, NeoplasmsEpigenetic AlterationsIn conclusion, our data indicate that miR-132 and miR-15a/16 act as tumor suppressor genes in pituitary tumor by directly targetting Sox5, and imply that these miRNAs have potential as therapeutic targets for invasive pituitary tumor.25305447
Colorectal Cancer PathwayEpigenetic AlterationsNuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer.25307864
Primary malignant neoplasmEpigenetic AlterationsEpigenetic changes are of crucial importance in cancer development and are potentially reversible; they are therefore targets of interest for anti-cancer therapy.25307864
Colorectal NeoplasmsEpigenetic AlterationsThe epigenetic markers were immunohistochemically stained on tissue microarrays containing colorectal tumours (n = 254) and normal colorectal tissues (n = 50).25307864
CarcinogenesisEpigenetic AlterationsThese results indicate that epigenetic mechanisms play an important role in colorectal carcinogenesis.25307864
Laryngeal Squamous Cell CarcinomaEpigenetic AlterationsMicroRNA-93 regulates cyclin G2 expression and plays an oncogenic role in laryngeal squamous cell carcinoma.25309979
Weight decreased, Obesity, Malignant neoplasm of liverEpigenetic AlterationsThe epigenetic age acceleration, which is not reversible in the short term after rapid weight loss induced by bariatric surgery, may play a role in liver-related comorbidities of obesity, such as insulin resistance and liver cancer.25313081
Malignant tumor of colon, MetastasisEpigenetic AlterationsMicroRNA classifier and nomogram for metastasis prediction in colon cancer.25315964
Malignant tumor of colonEpigenetic AlterationsIn addition, we recommend combination of miR16-5p and miR26a-5p as standard for normalization in qPCR of colon cancer tissue-derived miRNA expression.25315964
Tetranitromethane, NeoplasmsEpigenetic AlterationsIn conjunction with TNM staging, by means of a nomogram, this miRNA classifier may allow for personalized treatment decisions based on individual tumor characteristics.25315964
Primary malignant neoplasmEpigenetic AlterationsmiRNAs have been proposed as potential biomarkers for cancer.25315964
NeoplasmsEpigenetic AlterationsMicroRNA-224 is downregulated in mucinous cystic neoplasms of the pancreas and may regulate tumorigenesis by targeting Jagged1.25322937
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAn miRNA array identified miRNA expression level changes in response to NRF2 knockdown in AML cells.25323587
Leukemia, Myelocytic, AcuteEpigenetic AlterationsPosttranscriptional regulation by microRNAs (miRNAs) can affect the malignant phenotype of AML cells.25323587
Bladder NeoplasmEpigenetic AlterationsDNA methylation analysis showed tumor-specific TGS2 promoter methylation in 73% (38/52) of bladder tumors.25323766
Malignant neoplasm of urinary bladderEpigenetic AlterationsEpigenetic repression of regulator of G-protein signaling 2 by ubiquitin-like with PHD and ring-finger domain 1 promotes bladder cancer progression.25323766
Malignant neoplasm of urinary bladderEpigenetic AlterationsHowever, little is known about whether UHRF1 promotes bladder cancer progression by epigenetic silencing of RGS2.25323766
Malignant neoplasm of urinary bladderEpigenetic AlterationsThese results demonstrate that epigenetic repression of RGS2 by UHRF1 contributes to bladder cancer progression.25323766
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsCancer is a consequence of accumulation of genetic and epigenetic alterations in the cell which can lead to activation of oncogenes or inactivation of tumor suppressor genes (TSG).25324173
Toxicity aspectsEpigenetic AlterationsArsenic is associated with a number of health outcomes, with epigenetic modification suggested as a potential mechanism of toxicity.25325195
Colorectal Cancer PathwayEpigenetic AlterationsLong noncoding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer.25326054
Colorectal Cancer PathwayEpigenetic AlterationsTissue microRNAs as predictors of outcome in patients with metastatic colorectal cancer treated with first line Capecitabine and Oxaliplatin with or without Bevacizumab.25329796
Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsWe tested the hypothesis that expression of microRNAs (miRNAs) in cancer tissue can predict effectiveness of bevacizumab added to capecitabine and oxaliplatin (CAPEOX) in patients with metastatic colorectal cancer (mCRC).25329796
Breast Carcinoma, Ductal Carcinoma, Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsDNA methylation is a well-studied biomarker in invasive breast cancer, but its role in ductal carcinoma in situ (DCIS) is less well characterized.25331261
Primary malignant neoplasmEpigenetic AlterationsSHOX2 DNA methylation identified 66% of the patients with cancer subsequent to a cytological equivocal diagnosis.25331797
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsPrognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes.25332168
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsThe CpG island methylator phenotype (CIMP) of clear cell renal cell carcinomas (ccRCCs) is characterized by accumulation of DNA methylation at CpG islands and poorer patient outcome.25332168
Breast CarcinomaEpigenetic AlterationsIncreased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients.25333260
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs were additionally quantified in exosomes of 50 cancer patients and 12 healthy women from the same cohort.25333260
CarcinogenesisEpigenetic AlterationsLong non-coding RNAs (lncRNAs) play a key role in cellular processes, such as cell growth, apoptosis, and carcinogenesis.25337221
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNA-218 (miR-218) acts as a tumor suppressor in numerous types of cancer by regulation of the expression of target genes.25337271
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsBecause 3 untranslated region (3UTR) polymorphisms disrupting microRNA (miRNA) binding can be functional and can act as genetic markers of cancer risk, we aimed to determine genetic variation in the 3UTR of BRCA1/BRCA2 in familial and early-onset breast cancer patients with and without mutations in the coding regions of BRCA1/ BRCA2 and to identify specific 3UTR variants that may be risk factors for cancer development.25339023
Early-onset, Breast CarcinomaEpigenetic AlterationsEvaluation of genetic variations in miRNA-binding sites of BRCA1 and BRCA2 genes as risk factors for the development of early-onset and/or familial breast cancer.25339023
Ductal CarcinomaEpigenetic AlterationsExpression of DNA methylation marker of paired-like homeodomain transcription factor 2 and growth receptors in invasive ductal carcinoma of the breast.25339043
Adenocarcinoma of lung (disorder)Epigenetic AlterationsSmoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology.25342220
Carcinoma of lungEpigenetic AlterationsWe conclude that miRNAs disrupted in a smoking status-dependent manner affect distinct cellular pathways and differentially influence lung cancer patient prognosis in current, former and never smokers.25342220
Stomach CarcinomaEpigenetic AlterationsMicroRNA library-based functional screening identified miR-137 as a suppresser of gastric cancer cell proliferation.25342326
Stomach CarcinomaEpigenetic AlterationsmiRNA mimics were transfected into gastric cancer cell line SGC7901 and the effect of individual miRNA on the proliferation rate of the cells was measured by the RT-CES system.25342326
Malignant NeoplasmsEpigenetic AlterationsmiRNAs has been suggested to play a crucial role in the pathogenesis and development of various cancers.25342326
Primary malignant neoplasmEpigenetic AlterationsGenetic variation in miRNA-encoding sequences or their corresponding binding sites may affect the fidelity of the miRNA-mRNA interaction and subsequently alter the risk of cancer development.25342389
Admitting diagnosisEpigenetic AlterationsThese data suggest that an exosomal miRNA signature may have potential to be developed as a suitable peripheral screening tool for AD.25349172
Coronary Artery DiseaseEpigenetic AlterationsMicroRNA expression in circulating microvesicles predicts cardiovascular events in patients with coronary artery disease.25349183
Malignant Neoplasms, LymphomaEpigenetic AlterationsThe methylation of DNA at position 5 of cytosine, and the subsequent reduction in intracellular 5-hydroxymethylcytosine (5-hmC) levels, is a key epigenetic event in several cancers, including systemic lymphomas.25353265
NeoplasmsEpigenetic AlterationsPSD gene may function as a tumor suppressor in GC suggesting a vital role for DNA methylation and histone modification in PSD silencing.25355626
Stomach CarcinomaEpigenetic AlterationsThe Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance.25355626
Malignant Pleural MesotheliomaEpigenetic AlterationsUpregulation of microRNA-31 associates with a poor prognosis of malignant pleural mesothelioma with sarcomatoid component.25358615
Metastasis, Liver carcinomaEpigenetic AlterationsDownregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells.25361001
Clinical CoordinatorEpigenetic AlterationsAberrant microRNA expression holds great potential as diagnostic and prognostic biomarker for CRC.25362853
Alzheimers DiseaseEpigenetic AlterationsAssociation of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease.25365775
Admitting diagnosisEpigenetic AlterationsBrain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 was associated with pathological AD.25365775
PathologyEpigenetic AlterationsBrain DNA methylation in multiple AD loci is associated with AD pathologies.25365775
Admitting diagnosisEpigenetic AlterationsThe results provide further evidence that disruption of DNA methylation is involved in the pathological process of AD.25365775
Sarcoidosis, PulmonaryEpigenetic AlterationsDifferential inflammatory microRNA and cytokine expression in pulmonary sarcoidosis.25366387
Autoimmune reactionEpigenetic AlterationsAccordingly, changes in the expression of some miRNAs have been also associated with different autoimmune pathologies.25366387
Malignant tumor of colonEpigenetic AlterationsImportantly, the relationship between DNA methylation of PKCB and gene expression may warrant further attention in the context of colon cancer chemoprevention and anti-cancer therapy.25366420
Clear cell adenocarcinoma of ovaryEpigenetic AlterationsMicroRNA-21 is a candidate driver gene for 17q23-25 amplification in ovarian clear cell carcinoma.25366985
Malignant NeoplasmsEpigenetic AlterationsAberrant expression of microRNAs has been shown to be involved in oncogenesis, and microRNA-21 (miR-21) is frequently overexpressed in many types of cancers.25366985
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHowever, there was no report on the correlation of genome-wide DNA methylation with survival benefit from chemotherapy in NSCLC.25367137
Non-Small Cell Lung CarcinomaEpigenetic AlterationsUsing the sandwich ELISA method, we found that the genome-wide DNA methylation level in NSCLC cancer tissues was significantly lower than that in adjacent normal tissues, which further validated the assay.25367137
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) are small noncoding RNAs, which are involved in a great variety of pathological processes, particularly carcinogenesis.25367852
Stomach CarcinomaEpigenetic AlterationsThree dysregulated microRNAs in serum as novel biomarkers for gastric cancer screening.25367852
Primary malignant neoplasmEpigenetic AlterationsMiRNAs are stable in gastric juice, plasma as well as serum, which facilitate it to be a promising biomarker for cancer.25367852
Tetranitromethane, NeoplasmsEpigenetic AlterationsRelative expression of these miRNAs was significantly correlated with clinical characteristics of GC patients, such as TNM stage (P = 0.036 for miR-223; P < 0.001 for miR-100), metastatic status (P = 0.045 for miR-223; P = 0.031 for miR-16; P = 0.006 for miR-100), tumor size (P = 0.042 for miR-223; P = 0.031 for miR-16; P < 0.001 for miR-100), and differentiation grade (P = 0.036 for miR-223; P = 0.030 for miR-16; P = 0.034 for miR-100).25367852
Primary malignant neoplasmEpigenetic AlterationsSignificantly elevated expression of the three miRNAs was also observed in advanced GC patients, which suggested their availability in cancer staging.25367852
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTumor suppressor gene silencing through DNA methylation contributes to cancer formation.25367851
Glioblastoma Multiforme PathwayEpigenetic AlterationsIdentification and Evaluation of Serum MicroRNA-29 Family for Glioma Screening.25367878
Malignant NeoplasmsEpigenetic AlterationsConsidering the fact that miRNAs are stable in serum, plasma, urine, and other body fluids, they show great promises to be convenient and non-invasive biomarkers for cancers.25367878
Colorectal Cancer PathwayEpigenetic AlterationsPolymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients.25368035
Chronic Obstructive Airway Disease, Abnormal breathingEpigenetic AlterationsEpigenetic mechanisms in respiratory muscle dysfunction of patients with chronic obstructive pulmonary disease.25369292
Chronic Obstructive Airway DiseaseEpigenetic AlterationsEpigenetic events are differentially expressed in the lungs and airways of patients with chronic obstructive pulmonary disease (COPD).25369292
Functional disorder, Chronic Obstructive Airway DiseaseEpigenetic AlterationsMoreover, epigenetic mechanisms are involved in the skeletal (peripheral) muscle dysfunction of COPD patients.25369292
Chronic Obstructive Airway Disease, Abnormal breathingEpigenetic AlterationsWhether epigenetic events may also regulate respiratory muscle dysfunction in COPD remains unknown.25369292
Chronic Obstructive Airway Disease, Respiratory MusclesEpigenetic AlterationsWe hypothesized that epigenetic mechanisms would be differentially expressed in the main inspiratory muscle (diaphragm) of patients with COPD of a wide range of disease severity compared to healthy controls.25369292
Chronic Obstructive Airway DiseaseEpigenetic AlterationsIt is likely that these epigenetic events act as biological adaptive mechanisms to better overcome the continuous inspiratory loads of the respiratory system in COPD.25369292
Chronic Obstructive Airway Disease, Respiratory MusclesEpigenetic AlterationsIn the main respiratory muscle of COPD patients with a wide range of disease severity and normal body composition, muscle-specific microRNAs were downregulated, while HDAC4 and MEF2C levels were upregulated.25369292
Multiple MyelomaEpigenetic AlterationsThe pathogenesis of multiple myeloma involves complex genetic and epigenetic events.25369863
Multiple MyelomaEpigenetic AlterationsMALAT1 long non-coding RNA is overexpressed in multiple myeloma and may serve as a marker to predict disease progression.25369863
Prostate Cancer PathwayEpigenetic AlterationsHeterogeneity of DNA methylation in multifocal prostate cancer.25369892
NeoplasmsEpigenetic AlterationsCommon epigenetic profile of recurrent tumors can be inferred from our data.25369892
diabeticEpigenetic AlterationsInsulin-stimulated glucose uptake is decreased in differentiated diabetic cultured myotubes, which is in keeping with a retained genetic/epigenetic defect of insulin action.25370850
Malignant tumor of colonEpigenetic AlterationsMicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells.25371200
Malignant tumor of colon, methionineEpigenetic AlterationsIn this study, we systematically demonstrate that Ascl2 loss of function in colon cancer cells promotes MET by derepressing the expression of microRNA (miR)-200s (i.e.25371200
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsmicroRNA-338-3p functions as a tumor suppressor in human non-small-cell lung carcinoma and targets Ras-related protein 14. microRNAs (miRNAs) have been demonstrated to be important gene regulators with critical roles in diverse biological processes, including tumorigenesis.25374067
Primary malignant neoplasmEpigenetic AlterationsOf 72 paired samples, 65 cancer tissues overexpressed microRNA-200a greater than two fold in comparison with matched normal epithelium.25374174
ovarian neoplasmEpigenetic AlterationsOur findings support the notion that miR- 200a is an onco-microRNA for ovarian cancer, and elevation is a useful potential diagnostic indicator.25374174
B-Cell LymphomasEpigenetic AlterationsMicroRNA profiling of low-grade and transformed nodal marginal zone lymphoma reveals a similar signature pattern distinct from diffuse large B cell lymphoma.25376122
Hematologic NeoplasmsEpigenetic AlterationsMany hematologic malignancies exhibit distinct microRNA signatures.25376122
Diffuse Large B-Cell LymphomaEpigenetic AlterationsWhile microRNA signatures of low-grade and transformed NMZL did not differ significantly, several microRNAs were differentially expressed between transformed NMZL and DLBCL, hinting at molecularly distinct mechanisms of lymphomagenesis and indicating the biological disparity of transformed NMZL from DLBCL.25376122
Diffuse Large B-Cell LymphomaEpigenetic AlterationsIn the light of the unresolved issue regarding the classification of marginal zone-derived transformed B-cell neoplasms, microRNAs may be a valuable aid in discriminating NMZL from DLBCL.25376122
Liver carcinoma, NeoplasmsEpigenetic AlterationsGenome-wide profiling of DNA methylation and tumor progression in human hepatocellular carcinoma.25376281
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsTo clarify the progression pattern of abnormal DNA methylation during the development of hepatocellular carcinoma (HCC) using a comprehensive methylation assay.25376281
NeoplasmsEpigenetic AlterationsAltered DNA methylation patterns during tumor progression were also analyzed.25376281
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsDNA methylation-dependent transcriptional inactivation of tumor suppressor genes (TSGs) is critical for the pathogenesis of hepatocellular carcinoma (HCC).25376292
Hollings Cancer CenterEpigenetic AlterationsWe identified several potential TSGs that participate in transcription inactivation through epigenetic interactions in HCC.25376292
Hollings Cancer CenterEpigenetic AlterationsThe results of this study are important for the understanding of functionally important epigenetic alterations in HCC.25376292
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDifferential expression of microRNAs and their target genes in non-small-cell lung cancer.25376560
Carcinoma of lungEpigenetic AlterationsThere were significantly differentially expressed miRNAs and mRNAs between lung cancer and normal tissue.25376560
Non-Small Cell Lung CarcinomaEpigenetic AlterationsFurther investigation of miRNAs and their target genes is warranted to better understand NSCLC.25376560
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect.25379950
Primary malignant neoplasmEpigenetic AlterationsAssessment of the degree of an epigenetic field defect is a promising cancer risk marker that takes account of life history.25379950
Malignant NeoplasmsEpigenetic AlterationsCell free circulating microRNAs (cfmiRNAs) have been recognized as robust and stable biomarkers of cancers.25381453
Infection caused by Helicobacter pylori, Adenocarcinoma Of EsophagusEpigenetic AlterationsWhole-miRNome profiling identifies prognostic serum miRNAs in esophageal adenocarcinoma: the influence of Helicobacter pylori infection status.25381453
DiseaseEpigenetic AlterationsOver the past several years, evidence emerged that microRNAs (miRNAs), a class of small non-coding RNA molecules regulating gene expression at posttranscriptional level, play an important role in cell functioning, as well as in human diseases.25384507
Non-Small Cell Lung CarcinomaEpigenetic AlterationsExpression of miRNAs in non-small-cell lung carcinomas and their association with clinicopathological features.25384507
Carcinoma of lungEpigenetic AlterationsDetailed analysis revealed significant change in expression of miR-15a/16, miR-34a, miR-126, and miR-210 in NSCLC tumor samples indicating involvement of these miRNAs in lung cancer pathogenesis.25384507
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsSeveral recent studies have revealed that microRNAs (miRNAs) have a role in carcinogenesis and cancer development, and that it is stably detectable in plasma/serum.25384963
Blood CirculationEpigenetic AlterationsThe extracellular miRNAs circulate in the bloodstream and may serve as novel diagnostic and therapeutic biomarkers.25385173
Degenerative polyarthritisEpigenetic AlterationsCotransfection of OA chondrocytes with miR-608 or miR-602 mimic inhibited reporter activity, and mutation of the miRNA seed sequences abolished the repression of reporter activity.25385442
Degenerative polyarthritisEpigenetic AlterationsBecause interleukin-1b (IL-1b) has been implicated as a principal instigator of OA, we sought to determine whether IL-1b induces the expression of sonic HH (SHH) and its regulation by microRNAs (miRNAs) in human chondrocytes.25385442
Carcinoma of lungEpigenetic AlterationsDeregulation of serum microRNA expression is associated with cigarette smoking and lung cancer.25386559
Malignant Neoplasms, Carcinoma of lungEpigenetic AlterationsCirculating microRNAs (miRNAs) are considered potential biomarkers of various cancers, including lung cancer.25386559
Carcinoma of lungEpigenetic AlterationsIn conclusion, our results indicate that changes in serum miRNAs are associated with cigarette smoking and lung cancer and that let-7i-3p and miR-154-5p are potential biomarkers of smoking-related lung cancer.25386559
Bacterial sepsisEpigenetic AlterationsExpression profile of MicroRNAs in gram-negative bacterial sepsis.25394245
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLong-chain non-coding RNAs (lncRNAs) have been shown to be involved in the development and progression of non-small cell lung cancer (NSCLC).25394782
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-224 and its target CAMKK2 synergistically influence tumor progression and patient prognosis in prostate cancer.25394900
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsWe previously demonstrated that microRNA (miR)-224 expression was significantly reduced in human prostate cancer (PCa) tissues and predicted unfavorable prognosis in patients.25394900
NeoplasmsEpigenetic AlterationsWe previously demonstrated that constitutive activation of the Wnt signalling pathway by epigenetic silencing of secreted frizzled-related protein 4 (SFRP4) is observed in this tumour.25395299
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe present study implicates b-catenin promoter hypermethylation in the mechanism of epigenetic changes underlying NSCLC metastasis and progression, thus indicating the potential of b-catenin as a novel epigenetic target for the treatment of NSCLC patients.25396757
leprosy vaccineEpigenetic AlterationsTranscriptional changes that characterize the immune reactions of leprosy.25398459
Sample Size CalculationEpigenetic AlterationsSSc cases showed a distinct expression profile with 14/26 miRNA significantly decreased (false discovery rate < 0.05) and 5/26 increased compared with HC.25399392
Lupus Erythematosus, Systemic, Sample Size Calculation, hydrocortisoneEpigenetic AlterationsA 21-miRNA classifier gave optimum accuracy (80%) for discriminating SSc from both HC and SLE.25399392
hydrocortisone, Sample Size Calculation, Lupus Erythematosus, SystemicEpigenetic AlterationsThe discrimination between HC and SSc (95% accuracy) was strongly driven by miRNA of the 17 ~ 92 cluster and by miR-16, -223, and -638, while SLE and SSc differed mainly in the expression of miR-142-3p, -150, -223, and -638.25399392
Lupus Erythematosus, Systemic, Sample Size Calculation, hydrocortisoneEpigenetic AlterationsCirculating miRNA profiles are characteristic for SSc compared with both HC and SLE cases.25399392
Squamous cell carcinoma of esophagusEpigenetic AlterationsmicroRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma.25400770
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsPrevious studies observed the downregulation of microRNA (miR)-195 in esophageal squamous cell carcinoma (ESCC) tissues, confirmed cell division cycle 42 (Cdc42) as one target gene of miR-195, and demonstrated that miR-195 may act as a tumor suppressor in ESCC by regulating Cdc42 expression.25400770
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsStromal expression of MiR-21 predicts biochemical failure in prostate cancer patients with Gleason score 6. microRNAs (miRNAs) are involved in various neoplastic diseases, including prostate cancer (PCs).25401698
Malignant tumor of colonEpigenetic AlterationsWe quantified DNA methylation of mucin genes (MUC2, MUC5AC, MUC4) in colonic cancers and examined the association with clinicopathological characteristics and molecular (MSI, KRAS, BRAF, and TP53 mutations) features.25403854
Lymphoma, T-Cell, CutaneousEpigenetic AlterationsMicroRNA expression profiling and DNA methylation signature for deregulated microRNA in cutaneous T-cell lymphoma.25405321
Communicable Diseases, TSPYL2 wt Allele, Lymphoma, T-Cell, CutaneousEpigenetic AlterationsSupervised clustering confirmed a distinctive microRNA profile for cutaneous T-cell lymphoma (CTCL) with respect to ID.25405321
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs usually regulate gene expression negatively, and aberrant expression has been involved in the development of several types of cancers.25405321
Malignant neoplasm of urinary bladderEpigenetic AlterationsDual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer.25405368
Malignant NeoplasmsEpigenetic AlterationsOur recent studies of microRNA (miRNA) expression signatures revealed that the microRNA-23b/27b (miR-23b/27b) cluster is frequently downregulated in various types of human cancers.25405368
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsRestoration of mature miR-23b or miR-27b miRNAs significantly inhibited cancer cell migration and invasion, suggesting that these clustered miRNAs function as tumor suppressors.25405368
Renal Cell Carcinoma PathwayEpigenetic AlterationsMicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma.25405789
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, NeoplasmsEpigenetic AlterationsAberrant expression of miRNA-451a (miR-451a) has previously been reported in tumors, however its role in renal cell carcinoma (RCC) is currently unknown.25405789
Nasopharyngeal carcinomaEpigenetic AlterationsAlterations in the expression of several long non-coding RNAs (lncRNAs) have been found in primary nasopharyngeal carcinoma (NPC).25406670
Breast CarcinomaEpigenetic AlterationsAberrant DNA methylation is a key feature of breast carcinoma.25407397
Breast CarcinomaEpigenetic AlterationsOverall, the OR for breast cancer was 0.42 (95% CI 0.20-0.90) for the top versus bottom quartile of epigenome-wide DNA methylation and the OR for a one standard deviation increment was 0.69 (95% CI 0.50-0.95; test for linear trend, p = 0.02).25407397
protein expression, Type 2Epigenetic AlterationsMicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion.25408296
Communicable Diseases, CarcinogenesisEpigenetic AlterationsMicroRNA polymorphisms may be associated with carcinogenesis or immunopathogenesis of infection.25408584
Prostate Cancer PathwayEpigenetic AlterationsIn summary, miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers.25409297
Ischemic strokeEpigenetic AlterationsIdentification of circulating microRNAs as potential biomarkers for detecting acute ischemic stroke.25410304
atheroscleroticEpigenetic AlterationsGlobally, hypomethylation of chromosomal DNA predominates in atherosclerotic plaques and two-thirds of genes showing over 2.5-fold differential in DNA methylation are up-regulated in comparison to healthy mammary arteries.25411193
Vascular DiseasesEpigenetic AlterationsThese results suggest that epigenetic changes are involved in atherogenesis and may offer new potential therapeutic targets for vascular diseases.25411193
Malignant tumor of colon, NeoplasmsEpigenetic AlterationsDuring 3,206,985 person-years of follow-up, we identified 993 rectal and colon cancer cases with an available tumor DNA methylation status.25411283
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsThe association between alcohol intake and colorectal cancer risk may differ by tumor epigenetic features.25411283
Pancreatic carcinomaEpigenetic AlterationsLong noncoding RNA HULC is a novel biomarker of poor prognosis in patients with pancreatic cancer.25412939
Adenocarcinoma of large intestineEpigenetic AlterationsThe expression of multiple miRNAs, including miR-224, is deregulated in colorectal adenocarcinoma.25420464
Sample Size CalculationEpigenetic AlterationsTranscription factor Fli1, whose deficiency due to epigenetic suppression is implicated in the pathogenesis of SSc, occupied the CCN1 promoter and gene silencing of Fli1 resulted in the reduction of CCN1 expression in human dermal microvascular endothelial cells.25421497
Sample Size CalculationEpigenetic AlterationsThis study further supports the idea that epigenetic downregulation of Fli1 is a potential predisposing factor in the pathogenesis of SSc.25421497
Primary malignant neoplasm, Neoplasms, Cessation of lifeEpigenetic AlterationsEvidence indicates that a HPV+ diagnosis has significant prognostic implications; these patients have at least half the risk of death when compared with the HPV- patient, due in part to a better response to chemoradiotherapy (Fakhry et al., J Natl Cancer Inst 100:261-269, 2008).Epigenetic events of promoter hypermethylation are emerging as promising molecular strategies for cancer detection, representing tumor-specific markers occurring early in tumor progression.25421671
Colorectal Cancer PathwayEpigenetic AlterationsClinical significance of microRNA-21 as a biomarker in each Dukes stage of colorectal cancer.25421755
Malignant NeoplasmsEpigenetic AlterationsIt is known that microRNA-21 (miR-21) is implicated in the promotion, proliferation and progression of several types of human cancers.25421755
Clinical Coordinator, NeoplasmsEpigenetic AlterationsThe expression levels of miR-21 in the tumor tissues and normal adjacent tumor tissues of 306 CRC patients were determined by TaqMan microRNA assays.25421755
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsmiRNA-34a-5p may play a role as a tumor suppressor gene in colorectal cancer, with involvement of DNA methylation.25422210
Colorectal Cancer PathwayEpigenetic AlterationsExpression and clinical significance of miRNA-34a in colorectal cancer.25422210
Primary malignant neoplasmEpigenetic AlterationsSamples of cancer, paraneoplastic tissues and polyps were selected and total RNA was extracted by conventional methods for real-time PCR to detect the miRNA- 34a expression.25422210
Colorectal Cancer PathwayEpigenetic AlterationsIn addition, the LOVO colorectal cancer cell line was cultured, treated with the demethylating agent 5-azacytidine and screened for differentially expressed miRNA-34a.25422210
Colorectal Cancer PathwayEpigenetic AlterationsAfter the drug treatment, the miRNA-34a expression of colorectal cancer cell line LOVO was increased and real-time PCR showed that levels of expression in both cell line and colorectal cancer tissues were low, as compared to paraneoplastic tissue (p<0.05).25422210
In-Stent Restenosis IndicatorEpigenetic AlterationsPlasma microRNAs as potential noninvasive biomarkers for in-stent restenosis.25427155
Neoplasms, Renal Cell Carcinoma PathwayEpigenetic AlterationsmiRNA-205 is a candidate tumor suppressor that targets ZEB2 in renal cell carcinoma.25427583
Leukemia, Myelocytic, AcuteEpigenetic AlterationsA 3-microRNA scoring system for prognostication in de novo acute myeloid leukemia patients.25428263
Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe thus analyzed the clinical, genetic and microRNA profiling data of 138 de novo AML patients of our institute.25428263
Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe conclude that this 3-microRNA scoring system is simple and powerful for risk stratification of de novo AML patients.25428263
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNAs have florid biological functions and have critical roles in the pathogenesis and prognosis in AML.25428263
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe development of human cancer is a multistep process characterized by the accumulation of genetic and epigenetic alterations that drive or reflect tumour progression.25428504
Cerebrovascular accidentEpigenetic AlterationsThese DNA methylation patterns could be used as future potential stroke biomarkers.25429063
Cerebrovascular accident, ObesityEpigenetic AlterationsObesity and stroke are multifactorial diseases in which genetic, epigenetic and lifestyle factors are involved.25429063
Cerebrovascular accidentEpigenetic AlterationsFurthermore, the epigenetic marks differentially methylated in the stroke patients were dependent on the previous obese state.25429063
Degenerative polyarthritisEpigenetic AlterationsIdentification of long noncoding RNA associated with osteoarthritis in humans.25430712
Degenerative polyarthritisEpigenetic AlterationsLong noncoding RNAs (lncRNAs) are an important class of genes involved in various biological functions; however, knowledge about lncRNAs in osteoarthritis (OA) is limited.25430712
Malignant NeoplasmsEpigenetic AlterationsThe clinical utility of microRNA-21 as novel biomarker for diagnosing human cancers.25431259
Malignant NeoplasmsEpigenetic AlterationsRecently, microRNA-21 (miR-21) attracts much attention for its aberrant expression and has been widely studied in various cancers.25431259
Pancreatic carcinomaEpigenetic AlterationsHowever, the status of polycomb-associated histone modifications and their clinical implications in pancreatic cancer remain unclear.25431952
Tetranitromethane, Metastasis, NeoplasmsEpigenetic AlterationsFurthermore, compared to the tumor, lymph node, metastasis (TNM) staging system, histone modifications can discriminate the survival difference more accurately, especially for patients with stage I or stage II tumors.25431952
Pancreatic carcinomaEpigenetic AlterationsWe have proposed that epigenetic modifications may serve as discriminatory biomarkers for molecular staging of pancreatic cancer.25431952
frontal lobe, Cessation of lifeEpigenetic AlterationsTotal RNA, including microRNAs, was isolated from the cerebellum of individuals who had died from severe frontal cortex injuries or due to natural causes of death (reference group).25432860
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsLong non-coding RNA HOX transcript antisenseRNA (HOTAIR) has been widely identified to participate in tumour pathogenesis, acting as a promoter in colorectal cancer carcinogenesis.25432874
Metastasis, Liver carcinomaEpigenetic AlterationsMicroRNA-520g induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7.25436421
Hollings Cancer CenterEpigenetic AlterationsAberrant expression of miRNAs contributes to HCC development.25436421
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsNew findings have suggested the potential involvement of epigenetic mechanisms in Type 2 diabetes (T2DM) as a crucial interface between the effects of genetic predisposition and environmental influences.25437047
Metabolic DiseasesEpigenetic AlterationsThis finding highlights the potential role for epigenetic biomarkers as predictors of T2DM risk or other related metabolic disorders.25437047
Adenoma of large intestineEpigenetic AlterationsUsing colorectal adenomas, we investigated nucleosome positioning, DNA methylation, and gene expression in the early stages of gene silencing.25437056
Asthma PathwayEpigenetic AlterationsMicroRNA-19a enhances proliferation of bronchial epithelial cells by targeting TGFbR2 gene in severe asthma.25443138
Malignant NeoplasmsEpigenetic AlterationsAberrant expression of microRNA-148a (miR-148a) has been reported in several types of malignancies.25444499
Hollings Cancer CenterEpigenetic AlterationsmiR-148a might act as a suppressor miRNA of HCC and it therefore has a potential role in prognosis of HCC patients.25444499
Malignant Neoplasms, Ovarian CarcinomaEpigenetic AlterationsMicroRNA-145 (miR-145) expression is downregulated in several human cancers, but its clinical and functional relevance to ovarian carcinoma has not yet been elucidated.25444913
Squamous cell carcinoma of esophagusEpigenetic AlterationsLong intergenic noncoding RNA POU3F3 (linc-POU3F3) has been characterized as a highly conserved functional transcription regulator in esophageal squamous cell carcinoma.25445282
Primary malignant neoplasmEpigenetic AlterationsGrowing number of long intergenic noncoding RNAs (lincRNAs) have recently been identified in mammals as new modulators in cancer origination and progression involved in a broad range of biological processes.25445282
Prostate Cancer PathwayEpigenetic AlterationsIdentification of cell-free microRNAs in the urine of patients with prostate cancer.25445383
Primary malignant neoplasmEpigenetic AlterationsAccumulating evidence suggests that miRNAs play an important role in tumorigenesis, are differentially expressed in different cancer types, and can be found in all bodily fluids so-far tested, including urine.25445383
Prostate Cancer PathwayEpigenetic AlterationsLong noncoding RNA PCA3 gene promoter region is related to the risk of prostate cancer on Chinese males.25445501
Hollings Cancer CenterEpigenetic AlterationsAmong the 60 HCC cases, 76.7% (46/60) showed at elevated DNA methylation and displayed significantly lower levels of GPX3 mRNA and protein expression.25445749
atheroscleroticEpigenetic AlterationsThe identification of miR-33b and miR-758 as putative key regulators of ABCA1 protein expression within human atherosclerotic plaques provides further data for the realization of new anti-atherosclerotic drugs with specific targets based on anti-miRNA technologies.25445880
Malignant Neoplasms, Heart DiseasesEpigenetic AlterationsRecently, microRNAs have been detected in serum and plasma, and circulating microRNA (miRNA) profiles have now been associated with many diseases such as cancers and heart disease, as well as altered physiological states.25450382
Ovarian DiseasesEpigenetic AlterationsA novel serum microRNA panel to discriminate benign from malignant ovarian disease.25451316
NeoplasmsEpigenetic AlterationsMicroRNA profiling has allowed the identification of signatures associated with diagnosis, prognosis and response to treatment of human tumours.25451316
Primary malignant neoplasmEpigenetic AlterationsA panel of 4 microRNAs (let-7i-5p, miR-122, miR-152-5p and miR-25-3p) was significantly down regulated in cancer patients.25451316
CarcinogenesisEpigenetic AlterationsThese microRNAs target WNT signalling, AKT/mTOR and TLR-4/MyD88, which have previously been found to play a role in ovarian carcinogenesis and chemoresistance.25451316
Hepatitis B, Virus DiseasesEpigenetic AlterationsDifferences in serum microRNA profiles in hepatitis B and C virus infection.25452043
Viral hepatitisEpigenetic AlterationsSerum microRNA levels reflect differences in the etiology and stage of viral hepatitis.25452043
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsChanges in epigenetic marks may help explain the late onset of Alzheimers disease (AD).25452147
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsInterestingly, gene hypermethylation was detected in 13/37 tumors: 5/13 HNSCC cases had family history of cancer in first-degree relatives and 8/13 showed both, DNA methylation and PHF21B losses in the tumor sample.25454821
PHF21B gene, NeoplasmsEpigenetic AlterationsThese data suggest that PHF21B is a novel tumor suppressor gene that can be inactivated by genetic and epigenetic mechanisms in the human cancer.25454821
NeoplasmsEpigenetic AlterationsMicroRNA-26a (miR-26a) functions as a tumor suppressor by regulating its direct target gene high mobility group AT-hook 1 (HMGA1).25455159
Primary malignant neoplasm, Squamous Cell Carcinoma of the PenisEpigenetic AlterationsProfiling of expression of human papillomavirus-related cancer miRNAs in penile squamous cell carcinomas.25455689
Patient Satisfaction with Cancer Care QuestionnaireEpigenetic AlterationsAltered expression of miRNAs has been reported in HPV-related cervical and head and neck cancers, but such data have not been available for PSCC.25455689
Condyloma, Human papilloma virus infection, Human Papillomavirus-Related Malignant Neoplasm in AIDS PatientEpigenetic AlterationsWe analyzed a series of 59 PSCCs and 8 condylomata for presence of HPV infection, for p16(INK4a), Ki-67, and p53 immunohistochemical expression, and for expression of a panel of cellular miRNAs (let-7c, miR-23b, miR-34a, miR-145, miR-146a, miR-196a, and miR-218) involved in HPV-related cancer.25455689
Malignant NeoplasmsEpigenetic AlterationsThe long non-coding RNA SChLAP1 was identified as the highest-ranked overexpressed gene in cancers with metastatic progression.25456366
Malignant neoplasm of thyroidEpigenetic AlterationsDicer expression and microRNA dysregulation associate with aggressive features in thyroid cancer.25456905
Malignant Neoplasms, DICER1 protein, humanEpigenetic AlterationsAltered miRNA expression and down-regulation of Dicer has been shown in various cancers.25456905
Malignant neoplasm of thyroidEpigenetic AlterationsThese findings suggest that disruption in normal miRNA processing involving Dicer may play a role in thyroid cancer progression.25456905
DICER1 protein, human, Malignant neoplasm of thyroidEpigenetic AlterationsDysregulation of Dicer and possibly altered expression of miRNAs are associated with aggressive features in thyroid cancers.25456905
Carcinogenic Chlorinated Hydrocarbon, HepatitisEpigenetic AlterationsSerum levels of microRNA-122 were significantly higher in acute hepatitis and CHC patients than in healthy donors (p<0.001).25461662
Malignant neoplasm of breastEpigenetic AlterationsAberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers.25465188
Hematopoietic NeoplasmsEpigenetic AlterationsA novel intragenic long non-coding RNA (lncRNA) IRAIN within the IGF1R locus has been recently identified in haematopoietic malignancies using RNA-guided chromatin conformation capture (R3C).25465188
Parkinson DiseaseEpigenetic AlterationsmiRNA expression is highly sensitive to a drug therapy in Parkinsons disease.25465742
Parkinson DiseaseEpigenetic AlterationsmiRNAs may play a role in the pathogenesis of Parkinsons disease.25465742
Nerve Degeneration, Parkinson DiseaseEpigenetic AlterationsIt is necessary to continue the search for new miRNAs that may affect the development of neurodegeneration in Parkinsons disease.25465742
Parkinson DiseaseEpigenetic AlterationsIt is probable that miRNAs are very sensitive to drug therapy and that the effects of therapy observed may be associated with changes in the levels of these miRNAs and their target genes in patients with Parkinsons disease.25465742
NeoplasmsEpigenetic AlterationsTumor-specific DNA methylation of the ST6GAL1 promoter region was frequently found in pT2-4 tumors (53.6% (22/41)), whereas only 13.8% (4/29) of pTa tumors showed ST6GAL1 promoter methylation.25465919
Malignant neoplasm of urinary bladderEpigenetic AlterationsEpigenetic inactivation of ST6GAL1 in human bladder cancer.25465919
Esophagitis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsSerum inflammatory miRNAs predict radiation esophagitis in patients receiving definitive radiochemotherapy for non-small cell lung cancer.25466375
Toxicity aspectsEpigenetic AlterationsHigh serum miR-155 and miR-221 during the first 2 weeks of CRT were associated with the development of severe RIET, suggesting that these miRNAs may be useful as an early surrogate for this form of toxicity.25466375
Glioblastoma MultiformeEpigenetic AlterationsThe contrasting epigenetic role of RUNX3 when compared with that of MGMT and TIMP3 in glioblastoma multiforme clinical outcomes.25467143
Renal Cell Carcinoma PathwayEpigenetic AlterationsDNA methylation profiling reveals novel diagnostic biomarkers in renal cell carcinoma.25472429
Malignant neoplasm of kidney, Conventional (Clear Cell) Renal Cell Carcinoma, NeoplasmsEpigenetic AlterationsAdditionally, we identified a single panel of DNA methylation biomarkers that reliably distinguishes tumor from benign adjacent tissue in all of the most common kidney cancer histologic subtypes, and a second panel does the same specifically for clear cell renal cell carcinoma tumors.25472429
Malignant neoplasm of kidney, Renal Cell Carcinoma PathwayEpigenetic AlterationsThese DNA methylation profiles provide insights into the etiology of renal cell carcinoma and, most importantly, demonstrate clinically applicable biomarkers for use in early detection of kidney cancer.25472429
Disease, Primary malignant neoplasmEpigenetic AlterationsSingle nucleotide polymorphisms (SNPs) in the microRNA-binding sites in the 3 UTR region of target genes may result in the level change of target gene expression and subsequently susceptible to diseases, including cancer.25472585
Metastasis, NeoplasmsEpigenetic AlterationsOur data suggest that polymorphisms of the microRNA-binding sites in the 3 UTR region of integrin are associated with GC susceptibility (rs2675), tumor stage (rs2675, rs17664, and rs3809865), and lymphatic metastasis (rs17664) in Chinese Han population.25472585
Primary malignant neoplasmEpigenetic AlterationsAssociation of MicroRNA-31-5p with Clinical Efficacy of Anti-EGFR Therapy in Patients with Metastatic Colorectal Cancer.25472647
Clinical CoordinatorEpigenetic AlterationsWe recently reported that microRNA-31 (miR-31)-5p may regulate BRAF activation and play a role in the signaling pathway downstream of EGFR in CRC.25472647
Colorectal Cancer PathwayEpigenetic AlterationsClinical Relevance of Plasma DNA Methylation in Colorectal Cancer Patients Identified by Using a Genome-Wide High-Resolution Array.25472652
Malignant Neoplasms, Colorectal Cancer Pathway, Clinical Coordinator, NeoplasmsEpigenetic AlterationsDNA methylation is a potential tumor marker for several cancers, including colorectal cancer (CRC), because of its heritable and stable characteristics.25472652
Clinical CoordinatorEpigenetic AlterationsDNA methylation patterns differed in CRC subtypes.25472652
Colorectal Cancer PathwayEpigenetic AlterationsWe were able to show for the first time that in plasma miRNA profiles change within days after colorectal cancer surgery.25472670
Colorectal Cancer PathwayEpigenetic AlterationsSuitability of circulating miRNAs as potential prognostic markers in colorectal cancer.25472670
Primary malignant neoplasmEpigenetic AlterationsmiRNAs are crucial in cellular processes and have been shown to be abnormally expressed in cancer tissue and the circulation.25472670
Colorectal Cancer PathwayEpigenetic AlterationsOur results underscore the role of the investigated miRNAs in colorectal cancer and their potential utility as prognostic biomarkers.25472670
Functional disorder, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsAdverse epigenetic signatures by histone methyltransferase Set7 contribute to vascular dysfunction in patients with type 2 diabetes mellitus.25472959
Functional disorderEpigenetic AlterationsSet7-induced epigenetic changes contribute to vascular dysfunction in patients with T2DM.25472959
Primary malignant neoplasmEpigenetic AlterationsLong intergenic noncoding RNAs (lincRNAs) play important roles in regulating various biological processes in cancer, including proliferation and apoptosis.25473900
Primary malignant neoplasmEpigenetic AlterationsSingle-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) have been suggested to influence the occurrence and progression of cancer through altering the expression and biological function of miRNAs.25474430
NeoplasmsEpigenetic AlterationsEpigenetic modifiers, including the histone deacetylase inhibitor vorinostat, may sensitize tumors to chemotherapy and enhance outcomes.25476537
Septicemia, Traumatic injury, human herpesvirus 8Epigenetic AlterationsCellular and Kaposis sarcoma-associated herpes virus microRNAs in sepsis and surgical trauma.25476907
SepticemiaEpigenetic AlterationsCellular and KSHV miRNAs are differentially expressed in sepsis and early postsurgical patients and may be exploited for diagnostic and therapeutic purposes.25476907
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDownregulation of microRNA-21 expression restrains non-small cell lung cancer cell proliferation and migration through upregulation of programmed cell death 4.25477028
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs are endogenous non-coding RNAs that play important roles in a wide variety of biological processes such as apoptosis, development, aging and cancer.25479763
Malignant NeoplasmsEpigenetic AlterationsThe loss of 5-hydroxymethylcytosine (5-hmC) has been identified as an epigenetic hallmark in several malignancies.25480415
Conventional (Clear Cell) Renal Cell Carcinoma, NeoplasmsEpigenetic AlterationsUpregulation of long non-coding RNA MALAT1 correlates with tumor progression and poor prognosis in clear cell renal cell carcinoma.25480417
Pancreatic carcinomaEpigenetic AlterationsOverexpression of long non-coding RNA MALAT1 is correlated with clinical progression and unfavorable prognosis in pancreatic cancer.25481511
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been proved to serve as a critical role in cancer development and progression.25481511
CarcinogenesisEpigenetic AlterationsDNA methylation changes contribute to bladder carcinogenesis.25482586
Thymic CarcinomaEpigenetic AlterationsMutations of epigenetic regulatory genes are common in thymic carcinomas.25482724
ThymomaEpigenetic AlterationsOur results suggest a potential disruption of epigenetic homeostasis in TCs, and a substantial difference in genetic makeup between TCs and thymomas.25482724
SERPINB3 wt AlleleEpigenetic AlterationsTherefore, we evaluated the differential expression of six selected miRNAs namely hsa-miR-21, hsa-miR-125b2*, hsa-miR-138, hsa-miR-155, hsa-miR-184, and hsa-miR-205 in OSCC specimens of Indian ethnicity.25482863
Alzheimers Disease", Neurodegenerative DisordersEpigenetic AlterationsThere is increasing evidence that epigenetic modifications may become compromised in aging and increase susceptibility to the development of neurodegenerative disorders such as Alzheimers disease.25484284
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNAs (miRNAs) have been implicated in colorectal cancer (CRC) development and associated with prognostic indicators such as disease stage and survival.25484364
Clinical CoordinatorEpigenetic AlterationsIn this study, we utilize population-based data from 1,141 CRC cases to replicate previously reported associations between 121 miRNAs and disease stage and survival.25484364
NeoplasmsEpigenetic AlterationsFive miRNAs were associated with more advanced disease stage; hsa-miR-145-5p and hsa-miR-31-5p showed increased expression with more advanced tumor stage, while hsa-miR-200b-3p, hsa-miR-215 and hsa-miR-451a had decreased expression with more advanced tumors.25484364
Clinical Coordinator, Rectal Carcinoma, Malignant tumor of colonEpigenetic AlterationsThirteen miRNAs were associated with CRC mortality among individuals diagnosed with colon cancer while 14 were associated with CRC mortality after a diagnosis with rectal cancer.25484364
NeoplasmsEpigenetic AlterationsStrongest associations were observed for those miRNAs that were expressed in a small subset of tumors.25484364
ovarian neoplasmEpigenetic AlterationsHerpes virus microRNA expression and significance in serous ovarian cancer.25485872
ovarian neoplasmEpigenetic AlterationsGene, miRNA expression, and cytotoxicity assay were performed on multiple ovarian cancer cell lines transfected with miR-H25 and miR-BART7.25485872
ovarian neoplasmEpigenetic AlterationsThis is the first investigation linking viral miRNA expression to ovarian cancer outcome.25485872
Colorectal Cancer PathwayEpigenetic AlterationsAge-dependent clinical prognostic value of histone modifications in colorectal cancer.25488396
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsWe hypothesized that expression of histone modifications, acetylation of histone 3 lysine 9 (H3K9Ac) and trimethylation of histone 3 lysine 27 (H3K27me3), with reported normal age-related expression patterns might show an age-dependent prognostic value in colorectal cancer (CRC).25488396
Tetranitromethane, Clinical CoordinatorEpigenetic AlterationsTo quantify expression, we performed immunohistochemical staining of these histone modifications on a tissue microarray containing colorectal tissues of the 254 patients with TNM stage I-III CRC.25488396
Clinical CoordinatorEpigenetic AlterationsThese opposite expression patterns translated into an age-dependent prognostic value in CRC for the individual histone modifications and their combination.25488396
Primary malignant neoplasmEpigenetic AlterationsFurthermore, it is known that epigenetic mechanisms are involved in the development of cancer.25488396
Stomach Carcinoma, MetastasisEpigenetic AlterationsThe microRNA-367 inhibits the invasion and metastasis of gastric cancer by directly repressing Rab23.25489984
Stomach CarcinomaEpigenetic AlterationsDysregulated expression of microRNAs is often found in gastric cancer, and it contributes to the pathogenesis of gastric cancer via regulation of the cell cycle, proliferation, apoptosis, migration, and invasion.25489984
Merkel cell polyomavirusEpigenetic AlterationsmiRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma.25491743
NeoplasmsEpigenetic AlterationsHowever, distinct miRNA expression profiles have been suggested for MCV-positive and MCV-negative tumors.25491743
NeoplasmsEpigenetic AlterationsNeither tumor location nor development of metastases affected miRNA expression.25491743
Metabolic Diseases, Autoimmune Diseases, Primary malignant neoplasmEpigenetic AlterationsAs a new class of microregulators of gene expression, miRNA have been reported to play vital roles in autoimmune diseases, metabolic diseases and cancer.25495156
VitiligoEpigenetic AlterationsOur analysis showed that differentially expressed miRNA were associated with the mechanism of immune imbalance of vitiligo and that Ta1 could play an important role in changing the expression of these miRNA in the PBMC of patients with NSV.25495156
VitiligoEpigenetic AlterationsThis study provided further evidence that miRNA may serve as novel drug targets for vitiligo therapeutic evaluation.25495156
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsLEIGC long non-coding RNA acts as a tumor suppressor in gastric carcinoma by inhibiting the epithelial-to-mesenchymal transition.25496320
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs have been shown to have critical regulatory roles in cancer biology.25496320
Malignant NeoplasmsEpigenetic AlterationsForty-seven cancers varying by CIMP-status and IDH1 mutation status were examined using Illumina 450K DNA methylation microarrays.25496513
Colorectal Cancer PathwayEpigenetic AlterationsThis study provides a precedent that a single gene mutation may cause CIMP in colorectal cancer, and that this will be associated with a specific epigenetic signature and clinicopathological features.25496513
NeoplasmsEpigenetic AlterationsPatient, Design, Patients & Methods: MicroRNA expression signature was developed for RNA extracted from freshly frozen tumour and adjacent normal tissue (n = 5).25496852
Colonic NeoplasmsEpigenetic AlterationsIdentification of tissue specific microRNAs will help is designing microRNAs based gene therapies to control the development and progression of colonic neoplasia.25496852
Malignant Pleural MesotheliomaEpigenetic AlterationsMiR-score: a novel 6-microRNA signature that predicts survival outcomes in patients with malignant pleural mesothelioma.25497279
NeoplasmsEpigenetic AlterationsCandidate microRNAs from microarray profiling of tumor samples from 8 long (median: 53.7 months) and 8 short (median: 6.4 months) survivors following extrapleural pneumonectomy (EPP) were validated by RT-qPCR in 48 additional EPP samples.25497279
Antilymphocyte SerumEpigenetic AlterationsFor ALS, a total of 364 miRNAs were identified in the motor cortex, 91 being up-regulated and 233 down-regulated.25497327
Antilymphocyte SerumEpigenetic AlterationsThis indicated that one of the miRNAs up-regulated in ALS (miR-338-3p) had already been identified in leukocytes, serum, cerebrospinal fluid and frozen spinal cord from ALS patients.25497327
Carcinoma, Transitional Cell, Ulcerative Colitis, NeoplasmsEpigenetic AlterationsTo analyze a possible correlation between a miRNA expression profile and important prognostic factors for pTa urothelial carcinomas (UC), including tumor size, multiplicity and episodes of recurrence.25498275
Carcinoma, Transitional CellEpigenetic AlterationsMicro RNA expression and prognosis in low-grade non-invasive urothelial carcinoma.25498275
NeoplasmsEpigenetic AlterationsStatistical tests were used to compare tumor size, multiplicity and episodes of recurrence with miRNAs expression profiles.25498275
NeoplasmsEpigenetic AlterationsThe majority of miRNAs are down-regulated, except mir-10a, over-expressed in most of cases, seeming to have increased levels as tumor with more unfavorable prognostic factors.25498275
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsmicroRNA-137 functions as a tumor suppressor in human non-small cell lung cancer by targeting SLC22A18.25498886
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAs a result, bioinformatics analysis and luciferase reporter assay showed that microRNA (miRNA)-137 directly targeted SLC22A18 in NSCLC cells.25498886
Aggressive Non-Hodgkin LymphomaEpigenetic AlterationsGlobal microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma.25498913
Diffuse Large B-Cell LymphomaEpigenetic AlterationsWe identified a 27-miRNA signature that included v-myc avian myelomatosis viral oncogene homolog (MYC) targets and enabled the differentiation of BL from DLBCL, a distinction comparable with the "gold standard" GEP-defined diagnosis.25498913
Diffuse Large B-Cell Lymphoma, Mediastinal (Thymic) Large B-Cell LymphomaEpigenetic AlterationsDistinct miRNA signatures were identified for DLBCL subgroups, including GCB-DLBCL, activated B-cell (ABC)-DLBCL, and PMBL.25498913
Failure, Diffuse Large B-Cell LymphomaEpigenetic AlterationsWe also identified predictive miRNA biomarker signatures in DLBCL, including high expression of miR-155, which is significantly associated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) treatment failure.25498913
Glioblastoma Multiforme, Primary malignant neoplasm, Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA and mRNA expression data from glioblastoma (n = 475) and grade II and III glioma (n = 178) were accessed from The Cancer Genome Atlas.25499534
NeoplasmsEpigenetic AlterationsThe statistical significance of the microRNA signature was higher than MGMT methylation in temozolomide treated tumors.25499534
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe 9-microRNA risk score was validated in an independent dataset (p = 4.50e-02) and also stratified patients into high- and low-risk groups in lower grade glioma (p = 5.20e-03).25499534
Glioblastoma MultiformeEpigenetic AlterationsWe have identified a novel, biologically relevant microRNA signature that stratifies high- and low-risk patients in glioblastoma.25499534
Glioblastoma MultiformeEpigenetic AlterationsThe majority of the 9 microRNAs have been previously linked to glioblastoma biology or treatment response.25499534
Squamous cell carcinoma of esophagusEpigenetic AlterationsUsefulness of microRNA-375 as a prognostic and therapeutic tool in esophageal squamous cell carcinoma.25501018
NeoplasmsEpigenetic AlterationsThe growth of both the TE2 and T.Tn tumors in the miR-375 groups was significantly suppressed compared with that in the control-miRNA groups.25501018
LymphomaEpigenetic AlterationsThese epigenetic changes, seen in Tet2 insufficiency-triggered lymphoma, possibly contributed to predated outgrowth of Tfh-like cells and subsequent lymphomagenesis.25501021
Metastasis, NeoplasmsEpigenetic AlterationsLow level of miRNA-148/152 members may associate with advanced stage, large tumor size, malignant cell differentiation, and metastasis.25501703
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs were previously proposed as promising novel biomarkers in cancer screening.25501703
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe combination of four candidate miRNAs exhibited the highest predictive accuracy in NSCLC screening compared with individual miRNAs (AUC = 0.97).25501703
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHence, the four candidate miRNAs have great potential to serve as promising novel biomarkers in NSCLC screening.25501703
InitiationEpigenetic AlterationsMicroRNAs (miRNAs) are small noncoding RNAs with known regulatory functions in cancer initiation and progression.25501825
Carcinoma of lungEpigenetic AlterationsTransient and stable overexpression of mir-660 using miRNA mimics reduced migration, invasion, and proliferation properties and increased apoptosis in p53 wild-type lung cancer cells (NCI-H460, LT73, and A549).25501825
Carcinoma of lung, NeoplasmsEpigenetic AlterationsOur finding supports that mir-660 acts as a tumor suppressor miRNA and we suggest the replacement of mir-660 as a new therapeutic approach for p53 wild-type lung cancer treatment.25501825
NeoplasmsEpigenetic AlterationsDeregulation of microRNAs is a frequent event in the tumorigenesis and tumor progression.25502080
Carcinogenesis, NeoplasmsEpigenetic AlterationsAlthough microRNA-200 (miR-200) family members are thought to play roles in tumorigenesis, their functions in carcinogenesis are tumor specific, and the underlying mechanism of action still remains elusive.25502084
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLong noncoding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression.25504755
Metastasis, Primary malignant neoplasmEpigenetic AlterationsRecent evidence highlights long noncoding RNAs (lncRNA) as crucial regulators of cancer biology that contribute to essential cancer cell functions such as cell proliferation, apoptosis, and metastasis.25504755
Carcinogenic Chlorinated HydrocarbonEpigenetic AlterationsWe concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.25505813
Hypoxia, Degenerative polyarthritisEpigenetic AlterationsEffects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes.25510649
HypoxiaEpigenetic AlterationsThese findings demonstrate a role for hypoxia in the regulation of anabolic and catabolic gene expression and the influence of changes in DNA methylation.25510649
Degenerative polyarthritisEpigenetic AlterationsThere is also a growing body of evidence to support the role of epigenetic factors in the pathogenesis of OA.25510649
Carcinogenesis, Stomach CarcinomaEpigenetic AlterationsDysregulation of specific microRNAs (miRNAs) is found to play a vital role in carcinogenesis and progression of gastric cancer (GC).25510669
Malignant neoplasm of urinary bladderEpigenetic AlterationsEvaluation of urinary miRNA-96 as a potential biomarker for bladder cancer diagnosis.25511320
Malignant neoplasm of urinary bladder, Schistosomiasis, Lesion of bladderEpigenetic AlterationsUrine cytology, serologic assessment of schistosomiasis and estimation of miRNA-96 by real-time PCR were carried out for 94 bladder cancer patients, 30 benign bladder lesions and 60 healthy individuals.25511320
Malignant neoplasm of urinary bladderEpigenetic AlterationsUrinary miRNA-96 is a good noninvasive diagnostic biomarker for bladder cancer.25511320
NeoplasmsEpigenetic AlterationsFurthermore, we found that the promoter region of SRHC contains a CpG-rich island and that SRHC is down-regulated in tumors by DNA methylation.25512078
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsHere, we identified a new long noncoding RNA designated as SRHC that is capable of inhibiting cancer proliferation and is down-regulated in tumors at least partly by DNA methylation.25512078
Primary malignant neoplasm, Squamous cell carcinoma of esophagusEpigenetic AlterationsWe explored genome-wide DNA methylation data from The Cancer Genome Atlas project and identified a panel of tumor-related genes hypermethylated in ESCC.25514805
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsGlobal DNA methylation level, assessed by LINE-1, was significantly lower in ESCC than in normal mucosa (p < 0.0001), and lower in greater than or equal to T2 (n = 69) than T1 tumors (n = 45; p = 0.03).25514805
Primary malignant neoplasmEpigenetic AlterationsEpigenetic alterations contributing to this deadly cancer type that can be used as novel therapeutic or diagnostic targets are still poorly understood.25514805
Squamous cell carcinoma of esophagusEpigenetic AlterationsThis study demonstrates that epigenetic alterations of a panel of tumor-related genes and the noncoding region LINE-1 can be used as prognostic indicators and help in clinical management of ESCC patients.25514805
Metastasis, NeoplasmsEpigenetic AlterationsMicroRNAs regulate gene expression at the posttranscriptional level and play important roles in tumor development, progression, and metastasis.25515201
AtrophicEpigenetic AlterationsWe hypothesised that increased circulating and muscle growth and differentiation factor-15 (GDF-15) causes atrophy in ICUAW by changing expression of key microRNAs.25516419
Muscular AtrophyEpigenetic AlterationsGDF-15 may increase sensitivity to TGF-b signalling by suppressing the expression of muscle microRNAs, thereby promoting muscle atrophy in ICUAW.25516419
Primary malignant neoplasmEpigenetic AlterationsDownregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C.25518741
Primary malignant neoplasmEpigenetic AlterationsOur recent microRNA (miRNA) expression signatures of lung-SCC revealed that clustered miRNAs miR-1/133a were significantly reduced in cancer tissues.25518741
Clinical CoordinatorEpigenetic AlterationsOur findings suggest that the rs2910164 polymorphism in pre-miRNA, miR-146a may be associated with the risk of CRC.25519012
Colorectal Cancer PathwayEpigenetic AlterationsEvaluation of genetic variants in miRNAs in patients with colorectal cancer.25519012
Primary malignant neoplasmEpigenetic AlterationsAberrant expression and structural alteration of miRNAs are considered to participate in cancer development.25519012
Clinical Coordinator, Disease, Colorectal Cancer PathwayEpigenetic AlterationsIt has been suggested that common single-nucleotide polymorphisms (SNPs) in miRNAs are associated with susceptibility to several human diseases including colorectal cancer (CRC).25519012
Primary malignant neoplasmEpigenetic AlterationsAbnormally expressed circulating microRNA (miRNA) may serve as a potential biomarker for the diagnosis of cancer patients.25519019
Hepatitis B Virus-Related Hepatocellular CarcinomaEpigenetic AlterationsProfiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma.25519019
Hollings Cancer Center, Complete atrioventricular blockEpigenetic AlterationsRelative to healthy controls, nine, three, and 11 miRNAs were up-regulated in the CHB group, LC group and small HCC group, respectively.25519019
Neoplastic diseaseEpigenetic AlterationsMicroRNAs (miRNAs) are short, non-coding RNA molecules that are commonly dysregulated in neoplasia.25519020
Clinical CoordinatorEpigenetic AlterationsMiRNA microarray expression profiling was performed with Agilents miRNA Microarray system on 12 CRC and 8 normal stool samples.25519020
Clinical CoordinatorEpigenetic AlterationsIn profiling study, we found 215 down-regulated miRNAs in CRC group.25519020
Dental PlaqueEpigenetic AlterationsPlasma microRNA-100 is associated with coronary plaque vulnerability.25519160
methionine, Squamous cell carcinoma of lungEpigenetic AlterationsTumor-suppressive microRNA-206 as a dual inhibitor of MET and EGFR oncogenic signaling in lung squamous cell carcinoma.25522678
methionineEpigenetic AlterationsFurthermore, putative miR-206 binding sites were annotated in the 3-UTRs of MET and EGFR RTKs in miRNA databases.25522678
Atrial FibrillationEpigenetic AlterationsLeft atrial transcriptional changes associated with atrial fibrillation susceptibility and persistence.25523945
Degenerative polyarthritisEpigenetic AlterationsExpression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients.25524778
Degenerative polyarthritisEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have emerged as a novel class of regulatory molecules involved in various biological processes, but their role in osteoarthritis (OA) remains unknown.25524778
Squamous cell carcinomaEpigenetic AlterationsExpression and epigenetic regulation of DACT1 and DACT2 in oral squamous cell carcinoma.25524937
Malignant NeoplasmsEpigenetic AlterationsAbnormal expression of microRNA-146 (miR-146) has been found in several classes of cancers.25524940
F9 geneEpigenetic AlterationsMicroRNA-146a and miR-146b expressed in thyroid tissue may act as potential biomarkers for PTC patients.25524940
Primary malignant neoplasmEpigenetic AlterationsHuman miRNAs have emerged as potentially useful diagnostic and prognostic markers in cancer within the past decade.25524940
Prostate Cancer PathwayEpigenetic AlterationsThese data demonstrate that JUNB/AP-1 cooperates with PTEN signalling as barriers to invasive prostate cancer, whose concomitant genetic or epigenetic suppression induce malignant progression.25526087
Malignant Neoplasms, DICER1 protein, human, Pleuropulmonary blastoma, Stromal tumor of ovaryEpigenetic AlterationsDicer is an essential component of the microRNA-producing machinery; germline mutations of DICER1 have been confirmed in familial pleuropulmonary blastoma, ovarian sex cord-stromal tumors, and other cancers.25526195
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA LSINCT5 predicts negative prognosis and exhibits oncogenic activity in gastric cancer.25526476
NeoplasmsEpigenetic AlterationsLong non-coding RNAs (lncRNAs) are recently discovered RNA transcripts that are aberrantly expressed in many tumor types.25526476
Toxicity aspects, Drug-inducedEpigenetic AlterationsMicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.25527335
Myeloproliferative diseaseEpigenetic AlterationsRole of JAK2 V617F mutation and aberrant expression of microRNA-143 in myeloproliferative neoplasms.25527813
Colorectal Cancer PathwayEpigenetic AlterationsInvestigation of microRNA-155 as a serum diagnostic and prognostic biomarker for colorectal cancer.25528214
Transcriptional Regulator ATRX, HumanEpigenetic AlterationsWe demonstrate high-penetrance nonsense mutations in PDE4DIP (n = 4) as well as various missense mutations in the DNA damage response (PRKDC, AURKB, ERCC5, ATR, and ATRX) and epigenetic modulating enzymes (MLL3).25531179
Pathology, Primary malignant neoplasmEpigenetic AlterationsAltered DNA methylation is associated with important and common pathologies such as cancer.25531253
Colorectal Cancer Pathway, Neoplasm MetastasisEpigenetic AlterationsSTIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer.25531324
Clinical CoordinatorEpigenetic AlterationsMoreover, STIM1 was found to be a direct target of miR-185, a microRNA (miRNA) that has not previously been reported to be involved in EMT, in both CRC tissues and cell lines.25531324
Prostate Cancer PathwayEpigenetic AlterationsDysregulated microRNA-224/apelin axis associated with aggressive progression and poor prognosis in patients with prostate cancer.25532941
Prostate Cancer Pathway, Malignant Neoplasms, CHOANAL ATRESIA, POSTERIOR, NeoplasmsEpigenetic AlterationsOur previous study revealed that microRNA (miR)-224 down-regulation could promote tumor progression of prostate cancer (PCa) and might be associated with poor biochemical recurrence-free survival of patients with this malignancy.25532941
Primary central nervous system lymphomaEpigenetic AlterationsHere we characterised microRNA (miRNA) fingerprints in the blood of PCNSL patients with short-term survival (STS) versus long-term survival (LTS) to assess their potential as novel prognostic biomarkers.25534293
Primary central nervous system lymphomaEpigenetic AlterationsBesides the known miRNAs we identified putative novel miRNA candidates with potential regulatory influence of PCNSL.25534293
Primary central nervous system lymphomaEpigenetic AlterationsIn conclusion, peripheral blood miRNA expression patterns hold promise as a prognostic tool in PCNSL patients.25534293
ovarian neoplasmEpigenetic AlterationsThe BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2.25537514
ovarian neoplasmEpigenetic AlterationsBy analyzing multidimensional datasets of ovarian cancer patients from the TCGA data portal, we identified three miRNAs (hsa-miR-146a, hsa-miR-148a and hsa-miR-545) that target BRCA1/2 and were associated with overall survival and progression-free survival in patients with wild-type BRCA1/2.25537514
DiseaseEpigenetic AlterationsLong noncoding RNAs (lncRNAs) play an important role in the pathogenesis of many human diseases.25542208
Esophageal carcinoma, Neoplasm MetastasisEpigenetic AlterationsTGF-b1 induces epigenetic silence of TIP30 to promote tumor metastasis in esophageal carcinoma.25544767
Parkinson DiseaseEpigenetic AlterationsWe hypothesized that risk variants affect methylation of a putative promoter in SNCA intron 1, previously highlighted in epigenetic studies of Parkinsons disease.25545759
Epithelial-myoepithelial carcinoma, Primary malignant neoplasmEpigenetic AlterationsThese 220 differentially expressed genes including microRNAs provide here a sufficiently large set to specifically define epithelial-myoepithelial carcinoma and to identify novel and potentially important targets for diagnosis, prognosis, and therapy of this cancer.25546727
Stomach CarcinomaEpigenetic AlterationsExpression of serum let-7c, let-7i, and let-7f microRNA with its target gene, pepsinogen C, in gastric cancer and precancerous disease.25549793
Malignant NeoplasmsEpigenetic AlterationsHomeobox A5 (HOXA5) is a master regulator of the morphogenesis and cell differentiation, and its expression is also downregulated in many cancers mediated by DNA methylation.25549794
Primary malignant neoplasmEpigenetic AlterationsMicroRNA expressions in HPV-induced cervical dysplasia and cancer.25550598
Lesion of cervix, Human papilloma virus infectionEpigenetic AlterationsEvaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome.25550598
Breast Carcinoma, Esophageal carcinoma, Malignant Neoplasms, Primary malignant neoplasm, Malignant neoplasm of urinary bladder, Colorectal Cancer PathwayEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and the lncRNA UCA1 is upregulated in several cancers such as bladder cancer, breast cancer and colorectal cancer, however, the contributions of UCA1 to esophageal cancer remain largely unknown.25550835
Malignant tumor of colonEpigenetic AlterationsMicroRNA-139-3p indicates a poor prognosis of colon cancer.25550849
NeoplasmsEpigenetic AlterationsDysregulation of long non-coding RNAs (lncRNAs) plays critical roles in tumor progression.25550852
Malignant neoplasm of urinary bladderEpigenetic AlterationsAssociation detection between genetic variants in the microRNA binding sites of toll-like receptors signaling pathway genes and bladder cancer susceptibility.25550860
Primary malignant neoplasmEpigenetic AlterationsHowever, most existing studies have been focused on individual genes or a single type of data, which may lack the power to detect the complex mechanisms of cancer formation by overlooking the interactions of different genetic and epigenetic factors.25551281
ovarian neoplasm, Primary malignant neoplasmEpigenetic AlterationsWe propose an integrative framework to identify genetic and epigenetic features related to ovarian cancer and to quantify the causal relationships among these features using a probabilistic graphical model based on the Cancer Genome Atlas (TCGA) data.25551281
DiseaseEpigenetic AlterationsThe proposed framework is effective in identifying possible important genetic and epigenetic features that are related to complex cancer diseases.25551281
ovarian neoplasmEpigenetic AlterationsThe constructed Bayesian network has identified some new genetic/epigenetic pathways, which may shed new light into the molecular mechanisms of ovarian cancer.25551281
cervical cancerEpigenetic AlterationsDecreased expression of microRNA-126 is associated with poor prognosis in patients with cervical cancer.25551621
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-126(miR-126) has been shown to be frequently down-regulated in a variety of malignancies and act as a potential tumor suppressor.25551621
Ovarian Serous AdenocarcinomaEpigenetic AlterationsIdentification of microRNAs and target genes involved in serous ovarian carcinoma and their influence on survival.25556270
spindle orientation checkpoint, Ovarian Serous AdenocarcinomaEpigenetic AlterationsTo identify the expression of key microRNAs and their predicted target genes involved in serous ovarian carcinoma (SOC) and correlation between miRNAs and prognosis.25556270
Squamous cell carcinoma of esophagusEpigenetic AlterationsEpigenetic changes within the promoter regions of antigen processing machinery family genes in Kazakh primary esophageal squamous cell carcinoma.25556465
Primary malignant neoplasmEpigenetic AlterationsPosttranscriptional regulation of human leukocyte antigen class I (HLA-I) and antigen processing machinery (APM) proteins expression may be associated with novel epigenetic modifications in cancer development.25556465
NeoplasmsEpigenetic AlterationsOnly some of them result in genetic transcription, and silencing of HLA-B, ERp57, and LMP7 expression through hypermethylation of the promoters or other mechanisms may contribute to mechanisms of tumor escape from immune surveillance in Kazakh esophageal carcinogenesis.25556465
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsExpression of tumor suppressive microRNA-34a is associated with a reduced risk of bladder cancer recurrence.25556547
NeoplasmsEpigenetic AlterationsMicroRNA-34a (miR-34a) is a short noncoding regulatory RNA with tumor suppressive attributes.25556547
Refractory Cytopenia of ChildhoodEpigenetic AlterationsThis panel of 5 serum miRNA may have the potential to be used clinically as an auxiliary diagnostic tool for the early detection of RCC.25556603
Primary malignant neoplasm, Refractory Cytopenia of ChildhoodEpigenetic AlterationsCirculating microRNAs (miRNAs) are emerging as clinically useful tools for cancer detection; however, little is known about their early diagnostic impact on RCC.25556603
Renal Cell Carcinoma PathwayEpigenetic AlterationsA panel of five serum miRNAs as a potential diagnostic tool for early-stage renal cell carcinoma.25556603
Refractory Cytopenia of ChildhoodEpigenetic AlterationsMarkedly dysregulated miRNAs in RCC cases were subsequently validated individually by qRT-PCR in another 107 patients and 107 controls arranged in two sets.25556603
Colorectal Cancer PathwayEpigenetic AlterationsIdentification of high-risk Dukes B colorectal cancer by microRNA expression profiling: a preliminary study.25557290
Metastasis, NeoplasmsEpigenetic AlterationsThe study suggests that the development of metastasis in Dukes B tumours may be predictable based on the miRNA expression of miR-15b and miR-135b.25557290
Colorectal Cancer Pathway, Metastasis, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) from tumour tissue and common gene mutations were studied to determine whether they predict the development of metastasis in patients with Dukes B colorectal cancer.25557290
Colorectal Cancer Pathway, Metastasis, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMiRNAs from tumour and adjacent normal tissue and common gene mutations (KRAS, BRAF, PIK3CA) in primary cancer tissue were analysed to identify prognostic tissue markers for the development of metastasis in patients with Dukes B colorectal cancer.25557290
Colorectal Cancer PathwayEpigenetic AlterationsClinical significance of DNA methylation mRNA levels of TET family members in colorectal cancer.25557833
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsTherefore, we investigated DNA methylation and mRNA levels of all TETs in colorectal cancer (CRC) patients.25557833
cervical cancerEpigenetic AlterationsDownregulation of microRNA-145 is associated with aggressive progression and poor prognosis in human cervical cancer.25560490
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in the processes of tumor initiation and progression.25560490
Glioblastoma Multiforme PathwayEpigenetic AlterationsmicroRNA-328 is a favorable prognostic marker in human glioma via suppressing invasive and proliferative phenotypes of malignant cells.25562367
Glioma, NeoplasmsEpigenetic AlterationsmicroRNA (miR)-328 has been reported to be implicated into tumorigenesis and tumor progression in human gliomas.25562367
cervical cancer, InfectionEpigenetic AlterationsTo evaluate how the genetic and epigenetic profile of human papillomavirus 16 (HPV16) changes from asymptomatic cervical infections to cervical cancer (CaCx) development.25563334
Carcinoma of lung, MetastasisEpigenetic AlterationsInhibition of NADPH oxidase protects against metastasis of human lung cancer by decreasing microRNA-21.25563770
Malignant Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsReduced expression of microRNA-134 correlates with malignancy and poor prognosis in human glioma.25564273
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-134 (miR-134) has been demonstrated to be dysregulated in glioma tissues.25564273
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTo identify tumor suppressor genes (TSGs) silenced by hypermethylation and discover new epigenetic biomarkers for early cancer detection.25569086
Human papilloma virus infectionEpigenetic AlterationsDNA methylation in conjunction with HPV infection appears to play a role in OPSCC.25569158
Depressive disorder, Minimal Disseminated DiseaseEpigenetic AlterationsCurrent perspectives on the molecular underpinnings of major depressive disorder (MDD) posit a mechanistic role of epigenetic DNA modifications in mediating the interaction between environmental risk factors and a genetic predisposition.25571874
Myocardial IschemiaEpigenetic AlterationsEpigenetic screening may help identify determinants of therapeutic vasculogenesis in ischemic disease.25573856
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-15a down-regulation is associated with adverse prognosis in human glioma.25575767
Squamous cell carcinoma of skinEpigenetic AlterationsIn order to elucidate the role of epigenetic alterations in the development of cutaneous squamous cell carcinoma (SCC), we analyzed both gene-specific promoter hypermethylation and repetitive sequence hypomethylation in cutaneous SCC as well as normal skin tissue samples.25575897
Stomach CarcinomaEpigenetic AlterationsIdentification of long-range epigenetic silencing on chromosome 15q25 and its clinical implication in gastric cancer.25576785
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-93-5p (miR-93) is a novel oncogenic microRNA (miRNA) and is elevated in diverse human malignancies.25578493
Periampullary AdenocarcinomaEpigenetic AlterationsA total of 85 periampullary adenocarcinomas were characterized by mRNA and miRNA expressions profiling.25579086
Periampullary AdenocarcinomaEpigenetic AlterationsMolecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas.25579086
Malignant NeoplasmsEpigenetic AlterationsEpigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers.25579142
Breast CarcinomaEpigenetic AlterationsIdentification of obesity-associated epigenetic changes in breast tissue may advance mechanistic understanding of breast cancer initiation and progression.25583948
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsDNA methylation of ABCG1 might also play a role in previous hospitalized myocardial infarction (odds ratio, 1.15; 95% confidence interval=1.06-1.25).25583993
Liver carcinomaEpigenetic AlterationsIdentification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation.25584485
NeoplasmsEpigenetic AlterationsA significant positive correlation was demonstrated by comparing the changes in tumour size with the changes in cir-miRNA-126, r=0.48, P=0.0001.25584492
Chronic Lymphocytic LeukemiaEpigenetic AlterationsOpposite Prognostic Significance of Cellular and Serum Circulating MicroRNA-150 in Patients with Chronic Lymphocytic Leukemia.25584781
Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNAs (or miRs) play a crucial role in chronic lymphocytic leukemia (CLL) physiopathology and prognosis.25584781
Leukemia, Myelocytic, AcuteEpigenetic AlterationsPromoter DNA methylation and expression levels of HOXA4, HOXA5 and MEIS1 in acute myeloid leukemia.25585874
Malignant Neoplasms, Breast Carcinoma, Metastasis, Primary malignant neoplasmEpigenetic AlterationsOverexpression of Hox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with cancer cell proliferation, invasion, progression, and metastasis as well as poor survival in a variety of human cancers including breast cancer (BC).25586347
Carcinoma, Transitional CellEpigenetic AlterationsTo assess the impact of arsenic exposure at a time progressive manner, we developed and characterized a cell culture model and tested a panel of miRNAs in urine samples from arsenic-exposed subjects, urothelial carcinoma patients, and controls.25586904
Clinical CoordinatorEpigenetic AlterationsWhile, as expected, some miRNAs have been previously reported to be associated with CRC, including miR-21 and miR-145, others were new (miR-125a-5p and miR-320 family).25586944
Clinical CoordinatorEpigenetic AlterationsSome miRNAs were specific for the CRC versus NOR comparison (miR-320b), or for the CRA versus NOR comparison (miR-15b or miR-16), but several of them (miR-21, miR-24, miR-145, mir-150, miR-378) were deregulated in both CRAs and CRCs, as compared to NOR.25586944
Colorectal, Primary malignant neoplasmEpigenetic AlterationsWe confirmed that several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer.25586944
Colorectal Cancer PathwayEpigenetic AlterationsDifferences in the associations of a unique DNA methylation-based subgroup of colorectal cancer with important lifestyle and environmental exposures increase understanding of the molecular pathologic epidemiology of this heavily methylated subset of colorectal cancer.25587051
Congenital heart diseaseEpigenetic AlterationsDNA methylation abnormalities in congenital heart disease.25587870
DeformityEpigenetic AlterationsThese epimutations likely contribute to the pathogenesis of the malformation by cis-acting effects on gene expression.25587870
Congenital Heart DefectsEpigenetic AlterationsOur data indicate that epigenetic alterations of relevant genes are present in developing heart DNA in fetuses with both isolated and syndromic heart malformations.25587870
Stomach CarcinomaEpigenetic AlterationsEpigenetic changes and functional study of HOXA11 in human gastric cancer.25590359
Stomach CarcinomaEpigenetic AlterationsTo examine epigenetic changes and the function of HOXA11 in human gastric cancer (GC).25590359
Malignant NeoplasmsEpigenetic AlterationsDysregulation of long noncoding RNAs (lncRNAs) has been regarded as a primary feature of several human cancers.25590602
Breast CarcinomaEpigenetic AlterationsComprehensive DNA Methylation and Extensive Mutation Analyses of HER2-Positive Breast Cancer.25591616
HER2-positive carcinoma of breastEpigenetic AlterationsGenes involved in cancer-related pathways were frequently affected not only by genetic but also by epigenetic alterations in HER2-positive breast cancer.25591616
NeoplasmsEpigenetic AlterationsThe EGFL7 VA was significantly higher and the miRNA-126 VA significantly lower in regional lymph node metastases compared to primary tumours, p = 0.01 and p < 10(-6), respectively.25592646
Secondary malignant neoplasm of liver, Primary NeoplasmEpigenetic AlterationsFurthermore, the miRNA-126 VA in liver metastases was significantly lower than in the primary tumours, p = 0.02.25592646
Uveal melanomaEpigenetic AlterationsSkewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma.25593028
Primary malignant neoplasmEpigenetic AlterationsGiven the important role of epigenetic processes in cancer development and progression, we compared the transcriptional profiles of a selection of epigenetic regulators between primary UM with a good and a bad prognosis.25593028
NeoplasmsEpigenetic AlterationsIn the first set of tumors, general downregulation of transcription of the genes encoding epigenetic regulatory enzymes was seen in association with M3.25593028
Uveal melanomaEpigenetic AlterationsExpression levels of a number of histone-modifying genes and polycomb family members are significantly lower in uveal melanoma with monosomy 3/class 2, supporting a general dysregulation of epigenetic modifiers in UM with a bad prognosis.25593028
Multiple MyelomaEpigenetic AlterationsA serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma.25593199
Carcinoma of lungEpigenetic AlterationsSputum microRNA biomarkers for identifying lung cancer in indeterminate solitary pulmonary nodules.25593345
Carcinoma of lungEpigenetic AlterationsUsing quantitative RT-PCR, we evaluated expressions of 13 sputum miRNAs, previously identified sputum miRNA signatures of lung cancer, in a training set of 122 patients with either malignant (n = 60) or benign SPNs (n = 62) to define a panel of biomarkers.25593345
Peripheral Nerve Neoplasms, MalignantEpigenetic AlterationsIn the training set, a panel of three miRNA biomarkers (miRs21, 31, and 210) was developed, producing 82.93% sensitivity and 87.84% specificity for identifying malignant SPNs.25593345
Carcinoma of lung, Peripheral Nerve Neoplasms, MalignantEpigenetic AlterationsSputum miRNA biomarkers may improve LDCT screening for lung cancer in heavy smokers by preoperatively diagnosing malignant SPNs.25593345
Carcinoma of lungEpigenetic AlterationsWe have demonstrated that sputum miRNAs could provide potential biomarkers for lung cancer.25593345
Adrenocortical carcinomaEpigenetic AlterationsLong noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence.25595289
Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (lncRNAs) play an important role in cancer development.25595289
Adrenal Gland NeoplasmsEpigenetic AlterationsPathogenesis of adrenal tumours have been characterised by mRNA, microRNA and methylation expression signatures, but it is unknown if this extends to lncRNAs.25595289
Adult T-Cell Lymphoma/LeukemiaEpigenetic AlterationsA frequently affected pathway was the JAK/STAT pathway (18%) and a significant proportion of T-ALL patients harboured mutations in epigenetic regulators (33%), both predominantly found in the unfavourable subgroup of early T-ALL.25595890
Liver carcinomaEpigenetic AlterationsMicroRNA-34a expression is predictive of recurrence after radiofrequency ablation in early hepatocellular carcinoma.25596083
Hollings Cancer CenterEpigenetic AlterationsPrevious studies have reported that aberrant expression of microRNA-34a (miR-34a) is involved in oncogenesis and progression of HCC.25596083
Glioblastoma Multiforme PathwayEpigenetic AlterationsDecreased expression of microRNA-107 predicts poorer prognosis in glioma.25596705
Breast CarcinomaEpigenetic AlterationsMicroRNA-10b and minichromosome maintenance complex component 5 gene as prognostic biomarkers in breast cancer.25596707
Breast CarcinomaEpigenetic AlterationsThe expression of miRNA-10b and MCM5 mRNA was positive in 86.4 and 79.7 % breast cancer patients, respectively.25596707
Breast CarcinomaEpigenetic AlterationsThus, we could consider miRNA-10b and MCM5 mRNA as prognostic markers and potential therapeutic targets in breast cancer to be applied to other patient data sets.25596707
Prostate Cancer Pathway, Disease, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsAberrant elevation of JARID1B and histone H3 lysine 4 trimethylation (H3K4me3) is frequently observed in many diseases including prostate cancer (PCa), yet the mechanisms on the regulation of JARID1B and H3K4me3 through epigenetic alterations still remain poorly understood.25596733
NeoplasmsEpigenetic AlterationsIn the tumors, miRNAs (miR-125b-5p, miR-126-5p, miR-151a-5p, miR-221-3p, and miR-222-3p) were significantly upregulated with downregulation of miR-486-5p.25597612
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe small RNA transcriptomes obtained in this study uncovers six differentially expressed miRNAs and 12 novel miRNAs, and provides a better understanding of the expression and function of miRNAs in the development of PCa and reveals several miRNAs in PCa that may have biomarker and therapeutic potentials.25597612
Prostate Cancer PathwayEpigenetic AlterationsHere, we report on the evaluation of the diagnostic performance of ejaculate-derived PCA3, Hepsin, and miRNAs to complement serum PSA to detect prostate cancer.25597828
Prostate Cancer PathwayEpigenetic AlterationsFurthermore, a combination of serum PSA and selected miRNAs improved prediction of prostate cancer status.25597828
Renal Cell Carcinoma PathwayEpigenetic AlterationsLong Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205.25600645
Malignant Neoplasms, Refractory Cytopenia of Childhood, Renal Cell Carcinoma PathwayEpigenetic AlterationsRecently, long noncoding RNAs (lncRNA) have emerged as new gene regulators and prognostic markers in several cancers, including renal cell carcinoma (RCC).25600645
Clinical CoordinatorEpigenetic AlterationsThe molecular mechanisms underlying CRC development involve a multistep process with the accumulation of both genetic and epigenetic changes.25602156
Adenocarcinoma, DysplasiaEpigenetic AlterationsThese polyps contain BRAF mutations and are prone to epigenetic methylation that ultimately silences MLH1, leading to MSI and heralding progression of dysplasia to invasive adenocarcinoma.25602793
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA 196B regulates FAS-mediated apoptosis in colorectal cancer cells.25605245
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-10b is upregulated and has an invasive role in colorectal cancer through enhanced Rhoc expression.25606801
Pancreatic Intraductal Papillary Mucinous NeoplasmEpigenetic AlterationsA genome-wide investigation of microRNA expression identifies biologically-meaningful microRNAs that distinguish between high-risk and low-risk intraductal papillary mucinous neoplasms of the pancreas.25607660
Malignant NeoplasmsEpigenetic AlterationsThis pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy.25607660
Pancreatic CystEpigenetic AlterationsThe miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions.25607660
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDecreased microRNA-132 and its function in human non-small cell lung cancer.25607827
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-132 (miR-132) has been shown to be dysregulated in certain types of human malignancies and is associated with tumor progression.25607827
Prostate Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsOur study provides evidence that EphA5 is a potential target for epigenetic silencing in primary prostate cancer and is a potentially valuable prognosis predictor and thereapeutic marker for prostate cancer.25609195
Colorectal Cancer PathwayEpigenetic AlterationsGenome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer.25611389
Clinical CoordinatorEpigenetic AlterationsTherefore, our data have revealed several hundred potential miRNA-mRNA regulatory networks in CRC and suggest targeting relevant networks as potential therapeutic strategy for CRC.25611389
Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs have recently emerged as key regulators of cancer development and progression by targeting multiple cancer-related genes; however, such regulatory networks are not well characterized in CRC.25611389
Clinical CoordinatorEpigenetic AlterationsUsing target prediction and bioinformatics, ~77% of the upregulated genes were predicted to be targeted by microRNAs found to be downregulated in CRC.25611389
Clinical CoordinatorEpigenetic AlterationsSignificant inverse correlation between EZH2 and hsa-miR-26a-5p (R(2)=0.56, P=0.0001) and hsa-let-7b-5p (R(2)=0.19, P=0.02) expression was observed in the same samples, corroborating the belief of EZH2 being a bona fide target for these two miRNAs in CRC.25611389
Lupus Erythematosus, Systemic, Lupus ErythematosusEpigenetic AlterationsHistone acetylation modulates gene expression and has been described as increased in systemic lupus erythematosus (SLE).25611806
Lupus Erythematosus, SystemicEpigenetic AlterationsHistone acetylation was defined in monocytes and T cells from controls and SLE patients.25611806
AMD1 wt AlleleEpigenetic AlterationsResults also suggest that the degree of whole blood DNA methylation is not a marker of AMD.25611924
Glioblastoma Multiforme PathwayEpigenetic AlterationsLong noncoding RNA MALAT1 associates with the malignant status and poor prognosis in glioma.25613066
Adenocarcinoma of lung (disorder)Epigenetic AlterationsThe metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a bona fide long noncoding RNA (lncRNA).25613066
Carcinoma, Transitional CellEpigenetic AlterationsAberrant methylation of genes is one of the most common epigenetic modifications involved in the development of urothelial carcinoma.25613404
NeoplasmsEpigenetic AlterationsPRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene.25613750
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-149 suppresses colorectal cancer cell migration and invasion by directly targeting forkhead box transcription factor FOXM1.25613903
Cancer PrognosisEpigenetic AlterationsSequence Variation in Mature MicroRNA-499 Confers Unfavorable Prognosis of Lung Cancer Patients Treated with Platinum-Based Chemotherapy.25614447
Carcinoma of lungEpigenetic AlterationsWe found that the microRNA-499 rs3746444T>C polymorphism exhibited a consistently poor prognosis for patients with lung cancer in the discovery set [HR, 1.24; 95% confidence interval (CI), 1.02-1.49; P = 0.028], in the validation set I (HR, 1.31; 95% CI, 1.01-1.71; P = 0.048) and in the validation set II (HR, 1.45; 95% CI, 1.12-1.86; P = 0.004).25614447
Low Grade Cervical Squamous Intraepithelial NeoplasiaEpigenetic AlterationsAberrant DNA methylation of DLX4 and SIM1 is a predictive marker for disease progression of uterine cervical low-grade squamous intraepithelial lesion.25614457
Communicable DiseasesEpigenetic AlterationsAberrant DNA methylation of the DLX4 and SIM1 genes should be a novel progression marker for uterine cervical LSIL with hrHPV infection.25614457
melanoma, NeoplasmsEpigenetic AlterationsEpigenetic modifications in cutaneous malignant melanoma: EZH2, H3K4me2, and H3K27me3 immunohistochemical expression is enhanced at the invasion front of the tumor.25614949
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsCancer stem cells and the misregulation of epigenetic modifications have been identified to possess a determinative role in carcinogenesis.25614949
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTumor suppressor gene silencing through DNA methylation contributes to cancer formation.25616722
BDI - Functional Impairment, Neoplasms, Neoplasm MetastasisEpigenetic AlterationsAlthough deregulation of microRNA (miRNA) expression has been detected in many tumor types, the mechanisms underlying functional impairment and specific involvement of miRNAs in tumor metastasis remain unclear.25617495
Heart failureEpigenetic AlterationsCirculating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction.25619197
Squamous cell carcinoma of oropharynxEpigenetic AlterationsEpigenetic changes in the CDKN2A locus are associated with differential expression of P16INK4A and P14ARF in HPV-positive oropharyngeal squamous cell carcinoma.25619363
Oropharyngeal CarcinomaEpigenetic AlterationsOverall, this study provides evidence of epigenetic changes to the downstream region of the CDKN2A locus in HPV+ oropharyngeal cancer that are associated with changes in expression of the coded protein products.25619363
Multiple PregnancyEpigenetic AlterationsMicroRNAs (miRNAs) are small and highly conserved non-coding RNAs that regulate gene expression of target mRNAs through posttranscriptional inhibition involved in the tumorigenesis and progression of multiple malignancies.25620172
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-133a functions as a tumor suppressor in gastric cancer.25620172
Clinical CoordinatorEpigenetic AlterationsOur results demonstrate that EYA4 is under epigenetic regulation in CRC.25620232
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAberrant expression of microRNAs (miRs) has been proved to have a role in acute myeloid leukemias (AML), but there is no information on miR-331 in AML.25620533
ChordomaEpigenetic AlterationsUnderstanding epigenetic changes in chordomas may provide insights into chordoma tumorigenesis and development of epigenetic biomarkers.25621392
Primary malignant neoplasmEpigenetic AlterationsPreclinical studies suggest that noncytotoxic concentrations of the DNA methyltransferase 1 (DNMT1) inhibitor decitabine produce p53-independent cell-cycle exits by reversing aberrant epigenetic repression of proliferation-terminating (MYC-antagonizing) differentiation genes in cancer cells.25621498
NeoplasmsEpigenetic AlterationsOverexpression of the miRNA cluster 182/96/183 is specific in SDHB-mutated tumours and induces malignant traits, whereas silencing of the imprinted DLK1-MEG3 miRNA cluster appears as a potential driver in a subgroup of sporadic tumours.25625332
Polycystic Ovary SyndromeEpigenetic AlterationsMicroRNA-181a (miR-181a) is thought to be involved in posterior capsule opacification (PCO).25626972
NeoplasmsEpigenetic AlterationsAccumulating evidences indicate that microRNAs play a vital role in regulating tumor progression.25627001
Ulcerative Colitis, Crohn Disease, Inflammatory Bowel DiseasesEpigenetic AlterationsMicroRNAs (miRNAs) are dysregulated in the inflammatory bowel diseases, Crohns disease (CD) and ulcerative colitis (UC), which arise due to dysfunctional host-microbe interactions and impairment of the barrier function of the intestine.25628040
Ulcerative ColitisEpigenetic AlterationsHere, we sought to determine whether circulating miRNAs are biomarkers of active colonic CD and UC and can provide insights into disease pathogenesis.25628040
Rheumatoid Arthritis, Right armEpigenetic AlterationsComparison was made with serum miRNAs in patients with rheumatoid arthritis (RA).25628040
Malignant Neoplasms, Cancer of Urinary TractEpigenetic AlterationsMicroRNAs play an important role in many human malignancies; so far, their expression remains to be studied in upper urinary tract urothelial cancer (UUTUC).25629698
Primary malignant neoplasmEpigenetic AlterationsRecent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the blood and can serve as useful biomarkers for various types of cancer.25629978
ovarian neoplasmEpigenetic AlterationsMicroRNA let-7a modifies the effect of self-renewal gene HIWI on patient survival of epithelial ovarian cancer.25630839
ovarian neoplasmEpigenetic AlterationsAberrant expressions of self-renewal gene HIWI and microRNA (miRNA) let-7a are observed in epithelial ovarian cancer (EOC).25630839
Adenocarcinoma Of Esophagus, NeoplasmsEpigenetic AlterationsExosomal onco-miRs from serum of patients with adenocarcinoma of the esophagus: comparison of miRNA profiles of exosomes and matching tumor.25631748
NeoplasmsEpigenetic AlterationsOncogenic shuttle miRNAs present in exosomes may contribute to understanding how tumor cells spread their oncogenic potential to the environment.25631748
NeoplasmsEpigenetic AlterationsTumor specimens were analyzed for BRAF and KRAS mutations, CpG island methylator phenotype-specific promoters (CACNA1G, CDKN2A, IGF2 and RUNX3), IGFBP7, MGMT, MLH1 and RASSF2 methylation, microsatellite instability (MSI) and microRNA- 31 (miR-31).25632919
KMT2A gene, Malignant neoplasm of larynx, Primary malignant neoplasmEpigenetic AlterationsDeregulation of epigenetic effectors, including altered expression of histone methyltransferases from the MLL (mixed lineage leukemia) family, have been reported in many cancer types, yet little is known concerning their involvement in larynx cancer.25633166
Stomach CarcinomaEpigenetic AlterationsGastric cancer (GC) is a biologically heterogeneous disease accompanying various genetic and epigenetic alterations, and the molecular mechanisms underlying this disease are complex and not completely understood.25633292
Stomach Carcinoma, Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA-141 inhibits tumor growth and metastasis in gastric cancer by directly targeting transcriptional co-activator with PDZ-binding motif, TAZ.25633292
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsA tumor-specific microRNA signature predicts survival in clear cell renal cell carcinoma.25633718
Malignant neoplasm of kidney, Conventional (Clear Cell) Renal Cell Carcinoma, NeoplasmsEpigenetic AlterationsClear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancers in adults, and microRNAs (miRNAs) differentially expressed in ccRCC tumors have been identified and proposed to predict prognosis.25633718
Liver carcinomaEpigenetic AlterationsMicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A.25633810
Health maintenanceEpigenetic AlterationsSequence variants in miRNAs of patients with HCM are not frequent and the contribution of these variants to the development of this disease was not demonstrated.25633875
Multiple MyelomaEpigenetic AlterationsCorrelation between microRNA-21 and sprouty homolog 2 gene expression in multiple myeloma.25633921
Cluster, Primary cutaneous B-cell lymphomaEpigenetic AlterationsThe High Expression of the microRNA 17-92 Cluster and its Paralogs, and the Downregulation of the Target Gene PTEN, Is Associated with Primary Cutaneous B-Cell Lymphoma Progression.25634356
B-Cell LymphomasEpigenetic AlterationsThe oncogenic microRNA (miR) 17-92 cluster has a causative role in the lymphomagenesis of nodal B-cell lymphomas, by activating proliferation and inhibiting apoptosis.25634356
Liver carcinomaEpigenetic AlterationsHigh serum microRNA-122 level is independently associated with higher overall survival rate in hepatocellular carcinoma patients.25636448
ovarian neoplasmEpigenetic AlterationsMicroRNA-200c and microRNA-141 as potential diagnostic and prognostic biomarkers for ovarian cancer.25636451
Colorectal Cancer PathwayEpigenetic AlterationsDecreased expression of long noncoding RNA MEG3 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer.25636452
Breast CarcinomaEpigenetic AlterationsOur results provide evidence that well-defined DNA methylation profiles enable breast cancer prediction and patient stratification.25636590
Feel Pain, FibromyalgiaEpigenetic AlterationsRecently, microRNA dysregulation has been reported in patients with painful conditions such as complex regional pain syndrome and fibromyalgia.25636687
Migraine DisordersEpigenetic AlterationsIn conclusion, migraine manifestation is reflected in serum miRNA aberrations, both during attacks and pain-free periods.25636687
Nerve DegenerationEpigenetic AlterationsMicroRNAs have emerged as important biomarkers and modulators of pathophysiological processes including oncogenesis and neurodegeneration.25636687
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate a wide variety of cellular processes, and also play an important role in the development and progression of cancers.25637514
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation, which would be helpful in developing miRNA-based treatments for ESCC.25637514
Carcinoma of lungEpigenetic AlterationsEarly Detection of Lung Cancer in Serum by a Panel of MicroRNA Biomarkers.25639977
Carcinoma of lungEpigenetic AlterationsThe diagnostic value of the miRNA panel in an independent set of lung cancer patients confirmed the sensitivity and specificity.25639977
Carcinoma of lungEpigenetic AlterationsThe results demonstrated that the panel of miRNA biomarkers had the potential for the early detection of lung cancer.25639977
Carcinoma of lungEpigenetic AlterationsThe objective of the study was to develop a panel of microRNAs (miRNAs) as highly sensitive and specific biomarkers for lung cancer early detection.25639977
Carcinoma of lungEpigenetic AlterationsThe combination of the 3 miRNAs could produce 0.936 area under the receiver operating characteristic curve value in distinguishing early stage lung cancer patients from control subjects with 87.5% sensitivity and 87.5% specificity, respectively.25639977
Stomach CarcinomaEpigenetic AlterationsLong noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene in gastric cancer development.25640751
Congestive heart failureEpigenetic AlterationsWe demonstrated the increased expression levels of circulating miRNAs in CHF as compared with controls.25643195
Breast CarcinomaEpigenetic AlterationsRole of microRNAs -29b-2, -155, -197 and -205 as diagnostic biomarkers in serum of breast cancer females.25644077
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe most significantly modulated miRNAs in stimulated CLL are miR-132 and miR-212.25645730
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsThere is no clear understanding of the epigenetic alterations in hepatocellular carcinoma (HCC) and of the potential role of DNA methylation markers as prognostic biomarkers.25645722
Malignant NeoplasmsEpigenetic AlterationsEpigenetic deregulation has emerged as a driver in human malignancies.25645722
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer.25646356
Metastatic malignant neoplasm to brain, NeoplasmsEpigenetic AlterationsComparing patients with and without brain metastases, the expression of miRNA-328 and miRNA-378 in tumor tissues were significantly different (P = 6.2 x 10(-5) and P = 2.8 x 10(-5), respectively).25646356
Metastatic malignant neoplasm to brain, NeoplasmsEpigenetic AlterationsFor the patients with brain metastases, the expression of miRNA-328 and miRNA-378 in tumor tissues compared with para-carcinoma tissues were also significantly different (P = 2.2 x 10(-5) and P = 1.6 x 10(-5), respectively).25646356
Stomach CarcinomaEpigenetic AlterationsOverexpression of E2F mRNAs associated with gastric cancer progression identified by the transcription factor and miRNA co-regulatory network analysis.25646628
Stomach CarcinomaEpigenetic AlterationsThis study profiled differentially expressed mRNAs and miRNAs in gastric cancer tissues to construct a TF and miRNA co-regulatory network in order to identify altered genes in gastric cancer progression.25646628
Stomach CarcinomaEpigenetic AlterationsWe obtained 887 up-regulated and 93 down-regulated genes and 41 down-regulated and 4 up-regulated miRNAs in gastric cancer tissues.25646628
Carcinoma of lungEpigenetic AlterationsNPTX1 is a novel epigenetic regulation gene and associated with prognosis in lung cancer.25646694
Carcinogenesis, NeoplasmsEpigenetic AlterationsCpG island hypermethylation of gene promoters is a well-known mechanism of epigenetic regulation of tumor related-genes and is directly linked to lung carcinogenesis.25646694
Carcinoma of lungEpigenetic AlterationsEpigenetic alterations in NPTX1 may serve as potential diagnostic and prognostic biomarkers in lung cancer.25646694
leukemiaEpigenetic AlterationsEmerging evidences have suggested that microRNAs are involved in the pathogenesis of various leukemias.25646775
Adenocarcinoma of large intestineEpigenetic AlterationsAssociation of HPV with genetic and epigenetic alterations in colorectal adenocarcinoma from Indian population.25647260
Colorectal Cancer PathwayEpigenetic AlterationsWe studied the various genetic variations like microsatellite instability (MSI), oncogenic mutations and epigenetic deregulations like CpG island methylation in HPV associated and nonassociated colorectal cancer patients from Indian population.25647260
Colorectal Cancer PathwayEpigenetic AlterationsHPV in association with genetic and epigenetic features might be a potent risk factor for colorectal cancer in Indian population.25647260
MeningiomaEpigenetic AlterationsOverall, the results of this study confirm that DNA methylation plays an important role in the pathogenesis of meningiomas.25648363
Prostate Cancer PathwayEpigenetic AlterationsHere, we studied the epigenetic alteration of DLEC1 and its functions in prostate cancer.25648635
Prostate Cancer PathwayEpigenetic AlterationsDLEC1 methylation is associated with prostate cancer progression, which could be a non-invasive epigenetic biomarker for PrCa diagnosis.25648635
Ovarian CarcinomaEpigenetic AlterationsRhoC is a major target of microRNA-93-5P in epithelial ovarian carcinoma tumorigenesis and progression.25649143
Tuberculosis, PulmonaryEpigenetic AlterationsSingle nucleotide polymorphisms (SNPs) within precursor microRNAs (miRNAs) can affect miRNAs expression, and may be involved in the pathogenesis of pulmonary tuberculosis (TB).25650003
Adenocarcinoma of lung (disorder)Epigenetic AlterationsDNA methylation and RNA expression profiles in lung adenocarcinomas of never-smokers.25650174
Carcinoma of lungEpigenetic AlterationsEpigenetic changes in lung cancer potentially represent important diagnostic, prognostic, and therapeutic targets.25650174
Stomach Carcinoma, Atypical Glandular CellEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have been shown to be involved in the development and progression of advanced gastric cancer (AGC).25652469
Communicable DiseasesEpigenetic AlterationsIn summary, the expression pattern of miRNAs in the gastric mucosa is gradually increased with progression of Correas cascade and H.pylori infection, suggesting miRNAs as potential biomarkers for preneoplastic precursor conditions.25652892
Malignant neoplasm of urinary bladderEpigenetic AlterationsWD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription; however, its role in bladder cancer remains largely unknown.25656485
Malignant neoplasm of urinary bladderEpigenetic AlterationsOur research demonstrated the expression and clinical role of the microRNA-regulating machinery in bladder cancer.25656609
Heart failureEpigenetic AlterationsMicroRNA-214 Is Upregulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis.25656649
Cardiovascular DiseasesEpigenetic AlterationsMore and more miRNAs have been shown to regulate gene expression in the heart and dysregulation of their expression has been linked to cardiovascular diseases including the miR-199a/214 cluster.25656649
Choline Dehydrogenase, MitochondrialEpigenetic AlterationsWe identified a large difference in miRNA-mRNA associations between CHD cases and controls, as demonstrated by a significantly higher proportion of inversely correlated miRNA-mRNA pairs in cases versus controls (80% versus 30%; P<1x10(-16)), suggesting a genome-wide shift in the regulatory structure of the transcriptome in CHD.25657313
Choline Dehydrogenase, MitochondrialEpigenetic AlterationsOur results provide novel evidence that miRNAs are important regulators of biological processes involved in CHD via genetic control and via their tight coexpression with mRNAs.25657313
Ischemic strokeEpigenetic AlterationsmicroRNA (miRNA) plays a role in the pathogenesis of ischemic stroke, and single nucleotide polymorphisms in miRNA genes may contribute to disease susceptibility.25658319
Cerebrovascular accident, Ischemic strokeEpigenetic AlterationsIn summary, this study provides evidence that miR-146a/rs2910164 might be associated with a significantly increased risk of ischemic stroke in a Chinese population, and the combined effects between miRNA polymorphism and fasting glucose /blood lipid levels may contribute to stroke pathogenesis.25658319
Primary malignant neoplasmEpigenetic AlterationsSingle nucleotide polymorphisms (SNPs) in the 3-untranslated regions (UTRs) targeted by putative mircoRNAs (miRNAs) could influence the susceptibility of cancer.25661340
Prostate Cancer PathwayEpigenetic AlterationsRegulation of the ITGA2 gene by epigenetic mechanisms in prostate cancer.25662931
CarcinogenesisEpigenetic AlterationsEpigenetic silencing of miR-137 is a frequent event in gastric carcinogenesis.25663388
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNA) are involved in posttranscriptional regulation of gene expression and are dysregulated during carcinogenesis.25663388
Colorectal Cancer PathwayEpigenetic AlterationsIdentification of a metastasis-specific MicroRNA signature in human colorectal cancer.25663689
Secondary malignant neoplasm of liver, levamisoleEpigenetic AlterationsWe performed a systemic, comprehensive discovery for expression patterns of metastasis-specific microRNAs (miRNAs) by directly comparing primary CRCs (pCRCs) and matched liver metastases (LMs) and evaluated the feasibility of their clinical application as metastasis-specific biomarkers.25663689
Clinical Coordinator, MetastasisEpigenetic AlterationsThese unique miRNAs may be clinically applicable to predict prognosis and distant metastasis in CRC.25663689
Prostate Cancer Pathway, Malignant Neoplasms, CHOANAL ATRESIA, POSTERIOR, NeoplasmsEpigenetic AlterationsProstate cancer (PCa) represents one of the most complicated human tumors and, like many others malignancies, arises from progressive genetic and epigenetic alterations.25665470
ibudilastEpigenetic AlterationsAlthough the mechanisms deserve further investigation, microRNA is a potentially useful biomarker to differentiate IBD and MC.25665881
NeoplasmsEpigenetic AlterationsEight microRNAs (miR-4323, miR-625, miR-3619-3p, miR-4419b, miR-1249, miR-4648, miR-4664-3p and miR-1203) showed significant correlation with tumor relapse (p<0.01).25667451
Neoplasms, KLK7 geneEpigenetic AlterationsThe expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE.25667451
Squamous cell carcinoma, Primary malignant neoplasmEpigenetic AlterationsMicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways.25668004
SERPINB3 wt AlleleEpigenetic AlterationsAn OSCC miRNA signature was constructed by PCR-based array methods.25668004
Malignant Neoplasms, CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) have been shown to play major roles in carcinogenesis in a variety of cancers.25668004
Primary malignant neoplasmEpigenetic AlterationsRestoration of both miR-26a and miR-26b in cancer cell lines revealed that these miRNAs significantly inhibited cancer cell migration and invasion.25668004
Squamous cell carcinoma of esophagusEpigenetic AlterationsDownregulation of microRNA-1 in esophageal squamous cell carcinoma correlates with an advanced clinical stage and its overexpression inhibits cell migration and invasion.25672418
Squamous cell carcinoma of esophagusEpigenetic AlterationsRecent studies have suggested that an aberrant microRNA (miRNA or miR) expression signature exists in ESCC.25672418
Squamous cell carcinoma of esophagusEpigenetic AlterationsA total of 43 differentially expressed miRNAs, including 27 downregulated and 16 upregulated miRNAs were found in the ESCC tissue samples.25672418
Refractory Cytopenia of ChildhoodEpigenetic AlterationsIn addition, bioinformatics revealed that let-7, a microRNA formerly identified as an inhibiting factor of RCC was downregulated in RCC, which contrasted with S100A8.25673070
Malignant tumor of colonEpigenetic AlterationsThe CARLo-5, a newly identified long non-coding RNA, was found to be upregulated in colon cancer.25674211
Stomach CarcinomaEpigenetic AlterationsEnhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer.25674211
Primary malignant neoplasmEpigenetic AlterationsThe identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are vital for understanding the molecular biology and progression of cancer.25674211
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-584 functions as a tumor suppressor and targets PTTG1IP in glioma.25674221
Primary malignant neoplasmEpigenetic AlterationsCompelling evidence shows that there are causative links between miRNAs deregulation and cancer development and progression.25674221
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsUpregulation of microRNA-23a/b promotes tumor progression and confers poor prognosis in patients with gastric cancer.25674252
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsLong non coding RNAs (lncRNAs) have emerged recently as major players in tumor biology and may be used for cancer diagnosis, prognosis, and potential therapeutic targets.25674259
Lupus erythematosus tumidus, Stomach CarcinomaEpigenetic AlterationsDown-regulation of long non-coding RNA LET is associated with poor prognosis in gastric cancer.25674261
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have emerged recently as major players in tumor biology and may be used for cancer diagnosis, prognosis, and potential therapeutic targets.25674261
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsLysine specific demethylase 1 (LSD1), the first characterized histone demethylase, roles importantly in epigenetic regulation of carcinogenesis and cancer progression.25674267
Synucleinopathies, Behavior DisordersEpigenetic AlterationsMicroRNA association with synucleinopathy conversion in rapid eye movement behavior disorder.25675938
SynucleinopathiesEpigenetic AlterationsOur findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies.25675938
Malignant NeoplasmsEpigenetic AlterationsSpecimens underwent pyrosequencing for DNA methylation of genes reported to be hypermethylated in gynecologic cancers and recently identified markers discovered by profiling over 200 ECs.25677060
Squamous cell carcinoma of esophagusEpigenetic AlterationsLong noncoding RNA CCAT2 correlates with smoking in esophageal squamous cell carcinoma.25677908
Down SyndromeEpigenetic AlterationsAccelerated epigenetic aging in Down syndrome.25678027
nervous system disorder, Osteochondritis DissecansEpigenetic AlterationsmiRNAs, which are reported to be involved in the pathogenesis of the nervous system diseases, may also affect POCD.25680004
Breast CarcinomaEpigenetic AlterationsAssociation of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer.25680407
Breast CarcinomaEpigenetic AlterationsThe microRNA 17-92 cluster host gene (MIR17HG) has been shown to regulate expression of genes involved in breast cancer development and progression.25680407
Malignant NeoplasmsEpigenetic AlterationsDNA methylation of cytosine (5-methylcytosine (5-mC)) in CpG dinucleotides is a common DNA modification; CpG dinucleotides are considered to be mutational hotspots that cause genetic diseases and cancers through spontaneous deamination of 5-mC, resulting in C-T transition mutations.25682017
Stomach CarcinomaEpigenetic AlterationsMicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer.25682742
Childhood LeukemiaEpigenetic AlterationsThe DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression.25682873
Neoplastic diseaseEpigenetic AlterationsChanges in the status of DNA methylation are one of the most common molecular alterations in human neoplasia.25684670
Breast CarcinomaEpigenetic AlterationsWe aimed to identify epigenetic molecular markers in serum for early detection of breast cancer.25684670
Stomach CarcinomaEpigenetic AlterationsAntisense Long Noncoding RNA HIF1A-AS2 Is Upregulated in Gastric Cancer and Associated with Poor Prognosis.25686741
Malignant NeoplasmsEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have been recently shown to play important regulatory roles in fundamental biological processes, and many of them are deregulated in several human cancers.25686741
Carcinogenesis, NeoplasmsEpigenetic AlterationsIncreasing evidence suggests that miRNAs can act as either tumor suppressors or oncogenes in carcinogenesis.25686834
CarcinogenesisEpigenetic AlterationsSmall non-coding RNA deregulation in endometrial carcinogenesis.25686835
Carcinogenesis, NeoplasmsEpigenetic AlterationsSmall non-coding RNAs (sncRNAs) represent a heterogeneous group of <200nt-long transcripts comprising microRNAs, PIWI-interacting RNAs (piRNAs) and small-nucleolar-RNAs (snoRNAs) involved in physiological and pathological processes such as carcinogenesis and tumor progression.25686835
Acute lymphocytic leukemiaEpigenetic AlterationsAberrations in DNA methylation are detectable during remission of acute lymphoblastic leukemia and predict patient outcome.25687464
Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation patterns are a hallmark of cancer, although the extent to which they underlie cancer development is unknown.25687464
Stomach Carcinoma, MetastasisEpigenetic AlterationsThe correlation between miRNA and lymph node metastasis in gastric cancer.25688358
Prostate Cancer PathwayEpigenetic AlterationsA Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer.25691096
Prostate Cancer PathwayEpigenetic AlterationsWe hypothesized that a comprehensive analysis of genetic variations found within the 3 untranslated region of genes predicted to affect miRNA binding (miRSNP) can identify additional prostate cancer risk variants.25691096
Prostate Cancer PathwayEpigenetic AlterationsStudies of miRNAs and their interactions with SNPs could provide further insights into the mechanisms of prostate cancer risk.25691096
Squamous cell carcinoma of esophagusEpigenetic AlterationsWe previously revealed genetic and epigenetic alterations associated with esophageal SCCs in relation to clinical outcome, including mutations in KRAS, BRAF, and PIK3CA, p53 expression, and long interspersed nucleotide element-1 (LINE-1) methylation, a surrogate marker for global DNA methylation level.25691283
Squamous cell carcinoma of esophagus, Primary malignant neoplasmEpigenetic AlterationsThese findings imply that esophageal BSCC and SCC retain different cellular phenotypes with distinct genetic and epigenetic alterations; thus, tailored therapeutic strategies should be developed against each cancer type.25691283
Primary malignant neoplasmEpigenetic AlterationsIn summary, most of the epigenetic drift seen in blood is independent of changes in blood cell type composition, and exhibits patterns at different genomic length scales reminiscent of those seen in cancer.25692570
Diffuse Large B-Cell LymphomaEpigenetic AlterationsDevelopment and blind clinical validation of a microRNA based predictor of response to treatment with R-CHO(E)P in DLBCL.25692889
Primary malignant neoplasmEpigenetic AlterationsBased on the measured growth inhibition of 60 human cancer cell lines (NCI60) in the presence of doxorubicine, cyclophosphamide, vincristine and etoposide as well as the baseline microRNA expression of the 60 cell lines, a microRNA based response predictor to CHOP was developed.25692889
Diffuse Large B-Cell LymphomaEpigenetic AlterationsIt has been shown that microRNAs are independent predictors of outcome in patients with diffuse large B-cell lymphoma (DLBCL) treated with the drug combination R-CHOP.25692889
Stomach CarcinomaEpigenetic AlterationsCirculating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls.25694351
Stomach CarcinomaEpigenetic AlterationsHowever, it is unclear if serum long noncoding RNAs (lncRNAs) represent a novel marker to detect gastric cancer (GC).25694351
Esophageal carcinoma, Primary malignant neoplasmEpigenetic AlterationsmiRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma.25695396
Esophageal carcinoma, MetastasisEpigenetic AlterationsWe found that miRNA-1207-5p (miR-1207-5p) was markedly downregulated in esophageal carcinoma (EC) tissues, and was correlated with EC differentiation, pathological stage and lymph node metastasis.25695396
Cerebrovascular accident, Acute Cerebrovascular AccidentsEpigenetic AlterationsThe levels of miRNAs were compared with the presence of acute stroke, vascular risk factors, stroke subtypes, and stroke recurrence after index stroke.25697638
Mycosis FungoidesEpigenetic AlterationsAltered microRNA expression in folliculotropic and transformed mycosis fungoides.25698383
Small cell carcinoma of lungEpigenetic AlterationsMicroRNA-138 Regulates DNA Damage Response in Small Cell Lung Cancer Cells by Directly Targeting H2AX.25699650
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsMicroRNA-185 inhibits cell proliferation and induces cell apoptosis by targeting VEGFA directly in von Hippel-Lindau-inactivated clear cell renal cell carcinoma.25700976
Alcoholic Intoxication, ChronicEpigenetic AlterationsRecent studies have shown that smoking and alcoholism may be associated with altered DNA methylation and that alcohol consumption might induce changes in DNA methylation by altering homocysteine metabolism.25702197
Adenocarcinoma of lung (disorder)Epigenetic AlterationsHere we sought to determine the differential gene and microRNA expressions associated with field of cancerization in the peripheral airway epithelial cells of patients with lung adenocarcinoma.25705890
Primary malignant neoplasmEpigenetic AlterationsWe identified 26 mRNAs and 5 miRNAs that were significantly (FDR <0.1) up-regulated and 38 mRNAs and 12 miRNAs that were significantly down-regulated in the cancer patients when compared to smoker controls.25705890
Pancreatic carcinoma, Liver and Intrahepatic Biliary Tract CarcinomaEpigenetic AlterationsWe found 81 miRNAs for pancreatic cancer and 66 miRNAs for biliary-tract cancer that showed statistically different expression compared with healthy controls.25706130
Atrial FibrillationEpigenetic AlterationsIdentification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation.25706326
Stomach Carcinoma, Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA-181a inhibits tumor proliferation, invasiveness, and metastasis and is downregulated in gastric cancer.25706394
Malignant Neoplasms, Stomach CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) play crucial roles in the development and progression of human cancers, including gastric cancer.25706394
Stomach CarcinomaEpigenetic AlterationsThe discovery of miRNAs may provide a new and powerful tool for studying the mechanism, diagnosis, and treatment of gastric cancer.25706394
NeoplasmsEpigenetic AlterationsPrediction of desmoid tumor progression using miRNA expression profiling.25707497
hafniumEpigenetic AlterationsAs microRNAs (miRNAs) are key regulators in remodeling processes, a comparative miRNA profiling in transplanted hearts of HF patients with/without LVAD assistance could aid to comprehend underlying molecular mechanisms.25710008
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDe Novo Acute Myeloid Leukemia in Adults: Suppression of MicroRNA-223 is Independent of LMO2 Protein Expression BUT Associate With Adverse Cytogenetic Profile and Undifferentiated Blast Morphology.25710580
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNA (MIR) signatures are critical to pathobiology and prognosis of acute myeloid leukemia (AML).25710580
cervical cancerEpigenetic AlterationsMicroRNA-335 represents an independent prognostic marker in cervical cancer.25712373
Renal Cell Carcinoma PathwayEpigenetic AlterationsMiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib.25712526
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsThe identification of genetic determinants for this validated cancer biomarker should provide novel insights into mechanisms underlying epigenetic reprogramming during lung carcinogenesis.25713168
Secondary malignant neoplasm of prostateEpigenetic AlterationsDownregulation of microRNA-23a suppresses prostate cancer metastasis by targeting the PAK6-LIMK1 signaling pathway.25714010
Non-Small Cell Lung CarcinomaEpigenetic AlterationsA genetic variation in microRNA target site of KRT81 gene is associated with survival in early-stage non-small-cell lung cancer.25716425
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) have a key role in carcinogenesis through negative regulation of their target genes.25716425
Carcinoma of lungEpigenetic AlterationsOur findings underscore the impact of DNA methylation markers in symptomatic lung cancer diagnosis.25719833
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have shown to be promising novel biomarkers in various cancers.25720086
Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear FeaturesEpigenetic AlterationsMicroRNA deep-sequencing reveals master regulators of follicular and papillary thyroid tumors.25720323
CarcinogenesisEpigenetic AlterationsMicroRNA deregulation could be a crucial event in thyroid carcinogenesis.25720323
NeoplasmsEpigenetic AlterationsFurthermore, we integrated microRNA and gene expression data for the same tumors to propose targets for the novel molecules identified.25720323
Neoplasms, Papillary neoplasmEpigenetic AlterationsTwo main microRNA expression profiles were identified: one common for follicular-pattern tumors, and a second for papillary tumors.25720323
Follicular neoplasmEpigenetic AlterationsFollicular tumors showed a notable overexpression of several members of miR-515 family, and downregulation of the novel microRNA miR-1247.25720323
Papillary neoplasmEpigenetic AlterationsAmong papillary tumors, top upregulated microRNAs were miR-146b and the miR-221~222 cluster, while miR-1179 was downregulated.25720323
NeoplasmsEpigenetic AlterationsAlso, we confirmed that the PKM2/PKM1 ratio was further elevated in other PKM2-dominant organs such as colon through the down-regulation of these PTB1-associated microRNAs during tumor development.25721733
Primary malignant neoplasmEpigenetic AlterationsCompelling evidences have been demonstrated that microRNAs, a large family of single-stranded and non-protein-coding RNA molecules, can serve as useful biomarkers in cancer detection.25722112
ovarian neoplasmEpigenetic AlterationsSerum microRNA-145 as a novel biomarker in human ovarian cancer.25722112
DiseaseEpigenetic AlterationsIn summary, we discuss the phenotypic and diagnostic challenges in clinical genetics, establish important differential diagnoses, and emphasize the cardinal features and the broad clinical spectrum of BAF complex disorders and other disorders caused by mutations in epigenetic landscapers.25724810
Idiopathic Pulmonary FibrosisEpigenetic AlterationsDiscovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression.25725128
Idiopathic Pulmonary FibrosisEpigenetic AlterationsWe found 47 significantly differentially expressed serum miRNAs (p<0.05) in rapid progressive or slowly progressive IPF patients compared to healthy controls, including 21 up-regulated miRNAs and 26 down-regulated miRNAs.25725128
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsThe unique circulating microRNAs (miRNAs) observed in patients with type 2 diabetes (T2D) are candidates as new biomarkers and therapeutic targets.25726255
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsThe serum concentrations of miRNAs, log(10)miR-101, log(10)miR-375, and log(10)miR-802, were significantly increased in the T2D patients compared with NGT subjects (1.41+-2.01 v.s.25726255
Coronary Artery DiseaseEpigenetic AlterationsHere, we show that miR-320a, an intergenic miRNA, is markedly elevated in the peripheral blood of coronary heart disease patients and high-risk patients.25728840
Carcinoma, Signet Ring Cell, Gastric Tubular Adenocarcinoma, Stomach CarcinomaEpigenetic AlterationsDifferential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer.25730011
Carcinoma, Signet Ring Cell, Gastric Tubular AdenocarcinomaEpigenetic AlterationsThirteen dysregulated miRNAs were identified in signet-ring cell carcinoma compared with tubular adenocarcinoma: miR-30a, miR-26b, miR-381, let-7i, miR-29c, miR-543, miR-499-3p, miR-628-3p, miR-524-5p, miR-181b, miR-1914, miR-663b, and miR-676.25730011
Acute lymphocytic leukemia, Childhood LeukemiaEpigenetic AlterationsIn contrast to infant cases, MLL-R leukemia in older children had more somatic mutations (mean of 6.5 mutations/case versus 1.3 mutations/case, P = 7.15 x 10(-5)) and had frequent mutations (45%) in epigenetic regulators, a category of genes that, with the exception of MLL, was rarely mutated in infant MLL-R ALL.25730765
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-630 (miR-630) has been shown to be involved in various human malignancies.25731670
Prostate Cancer PathwayEpigenetic AlterationsSeveral expression profiling studies have provided evidence of aberrant expression of miRNAs in prostate cancer and have highlighted the potential use of specific miRNA expression signatures as prognostic or predictive markers.25731699
Primary malignant neoplasmEpigenetic AlterationsRecently, there has been increasing attention on the role of microRNAs (miRNAs) in cancer development.25731699
Prostate Cancer PathwayEpigenetic AlterationsqRT-PCR was performed to validate the differential expression of miRNAs in clinical samples, and the effect of miR-1247-5p was studied in prostate cancer cell lines transiently transfected with a miR-1247-5p mimic.25731699
Squamous cell carcinoma of esophagusEpigenetic AlterationsUpregulation of the long noncoding RNA PCAT-1 correlates with advanced clinical stage and poor prognosis in esophageal squamous carcinoma.25731728
Prostate Cancer Pathway, ProstateEpigenetic AlterationsProstate cancer-associated ncRNA transcript 1 (PCAT-1) is one of the lncRNAs involved in cell apoptosis and proliferation of prostate cancer.25731728
Primary malignant neoplasmEpigenetic AlterationsRecent studies reveal that long noncoding RNAs (lncRNAs) play critical regulatory roles in cancer biology.25731728
Breast Carcinoma, MetastasisEpigenetic AlterationsBreast Cancer: Radiogenomic Biomarker Reveals Associations among Dynamic Contrast-enhanced MR Imaging, Long Noncoding RNA, and Metastasis.25734557
Medial collateral ligamentEpigenetic AlterationsPrognostic miRNAs were validated in diagnostic MCL samples from 94 patients of the independent Nordic MCL3 trial (validation cohort).25736311
Medial collateral ligamentEpigenetic AlterationsThree miRNAs (miR-18b, miR-92a, and miR-378d) were significantly differentially expressed in patients who died of MCL in both cohorts.25736311
Nasopharyngeal carcinoma, NeoplasmsEpigenetic AlterationsProtocadherin20 Acts as a Tumor Suppressor Gene: Epigenetic Inactivation in Nasopharyngeal Carcinoma.25736877
NeoplasmsEpigenetic AlterationsOur study identified PCDH20 as a functional tumor suppressor and an important antagonist of Wnt/b-catenin signaling and EMT, with frequent epigenetic inactivation in NPC.25736877
Intimal proliferation, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsAberrant expression of microRNAs is associated with neointimal hyperplasia (NIH) in type 2 diabetes.25737017
Malignant neoplasm of urinary bladderEpigenetic AlterationsIdentification and validation of reference genes for the detection of serum microRNAs by reverse transcription-quantitative polymerase chain reaction in patients with bladder cancer.25738263
Primary malignant neoplasmEpigenetic AlterationsSerum microRNAs (miRNAs) have been proposed as novel non-invasive biomarkers for the early detection of cancer.25738263
Nasopharyngeal carcinoma, MetastasisEpigenetic AlterationsIdentification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma.25738365
Malignant Neoplasms, Nuclear Pore ComplexEpigenetic AlterationsMicroRNAs (miRNAs) play many important roles in human cancers; hence, we proceeded to address the primary hypothesis that there is a miRNA expression signature capable of predicting DM for NPC patients.25738365
Diabetes MellitusEpigenetic AlterationsA 4-miRNA expression signature associated with risk of developing DM was identified by fitting a penalized Cox Proportion Hazard regression model to the Training data set (HR 8.25; p < 0.001), and subsequently validated in an independent Validation set (HR 3.2; p = 0.01).25738365
TetranitromethaneEpigenetic AlterationsThis 4-miRNA signature adds to the prognostic value of the current "gold standard" of TNM staging.25738365
Heart failureEpigenetic AlterationsSignificant differences in the miRNA expression profiles were observed between patients with different stages of heart failure following MI and individuals in the normal control group.25738515
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsA subset of circulating microRNAs is expressed differently in patients with myocardial infarction.25738515
Breast CarcinomaEpigenetic AlterationsmicroRNA-214 enhances the invasion ability of breast cancer cells by targeting p53.25738546
NeoplasmsEpigenetic AlterationsmicroRNA-214 (miR-214), a member of the miRNA family, has been demonstrated to function as both a tumor suppressor and oncogene in various types of human cancer.25738546
Heart failureEpigenetic AlterationsMicroRNA signatures differentiate preserved from reduced ejection fraction heart failure.25739750
Stomach Carcinoma, Aggressive behaviorEpigenetic AlterationsEpigenetic clustering of gastric carcinomas based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome.25740824
CarcinogenesisEpigenetic AlterationsThe aim of this study was to clarify the significance of DNA methylation alterations during gastric carcinogenesis.25740824
Stomach Carcinoma, Aggressive behaviorEpigenetic AlterationsThese data indicate that DNA methylation profiles at the precancerous stage may be inherited by gastric carcinomas themselves, thus determining tumor aggressiveness and patient outcome.25740824
Epstein-Barr virus associated gastric carcinomaEpigenetic AlterationsThe results demonstrated the antiapoptotic role of EBV miRNA via regulation of Bid expression in EBV-associated gastric carcinoma.25740983
Stomach CarcinomaEpigenetic AlterationsProfiling of Virus-Encoded MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma and Their Roles in Gastric Carcinogenesis.25740983
CarcinogenesisEpigenetic AlterationsThese findings provide novel insights in the roles of EBV miRNAs in gastric carcinogenesis, which would be a potential therapeutic target.25740983
Epstein-Barr virus associated gastric carcinomaEpigenetic AlterationsThis report is the largest series to comprehensively profile the expression of 44 known EBV miRNAs in clinical samples from EBV-associated gastric carcinoma patients.25740983
CarcinogenesisEpigenetic AlterationsOf the EBV miRNAs, ebv-miR-BART4-5p plays an important role in gastric carcinogenesis via regulation of apoptosis.25740983
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNAs can function as key tumor suppressors or oncogenes and act as biomarkers for cancer diagnosis or prognosis.25742499
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumor suppressor genes due to promoter hypermethylation is one of the frequent mechanisms observed in cancers.25743838
ovarian neoplasm, AscitesEpigenetic Alterations[Elevated levels of dendritic cell-correlated miRNAs in ascites and sera of patients with ovarian cancer].25744846
Primary malignant neoplasmEpigenetic AlterationsMicroRNA has become an ideal biomarker for cancer diagnosis, prognosis and therapy.25746592
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe relationship between microRNA-141 and non-small cell lung cancer (NSCLC) is contradictory.25746592
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe expression level of microRNA-141 was significantly higher in NSCLC tissues than in adjacent lung tissues (P < 0.001), detected by real time RT-PCR.25746592
Non-Small Cell Lung CarcinomaEpigenetic AlterationsReceiver operating characteristic (ROC) exhibited a moderate diagnostic value of microRNA-141 for NSCLC with the area under curve of 0.707.25746592
Metastasis, Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsThe microRNA-141 expression increased with the larger tumor size (P = 0.002), lymph node metastasis (P = 0.018) and advanced stage (P = 0.022) in NSCLC patients.25746592
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn conclusion, microRNA-141 is a potential biomarker for the molecular diagnosis and risk stratification of NSCLC.25746592
Hypoxia, Metastasis, melanomaEpigenetic AlterationsA direct plasma assay of circulating microRNA-210 of hypoxia can identify early systemic metastasis recurrence in melanoma patients.25749524
NeoplasmsEpigenetic AlterationsMicroRNA-210(miR-210) is known to play important roles in the tumor hypoxic state.25749524
ConstipationEpigenetic AlterationsThe Relationship Between Colonic Macrophages and MicroRNA-128 in the Pathogenesis of Slow Transit Constipation.25749934
ConstipationEpigenetic AlterationsCompared to controls, 20 of 25 slow transit constipation patients (80 %) had significantly higher numbers of macrophages in colonic specimens, coupled with down-regulation of microRNA-128.25749934
ConstipationEpigenetic AlterationsHowever, there are almost no data concerning colonic macrophages and microRNAs in slow transit constipation.25749934
Metastasis, Primary malignant neoplasmEpigenetic AlterationsRecent studies have revealed dysregulated expression of several microRNAs (miRNAs) in various cancer tissues, and therefore, these cancer-associated miRNAs (also called onco-miRs) could be promising prognostic biomarkers of cancer progression or metastasis.25750291
SCGB3A1 wt Allele, Glioblastoma MultiformeEpigenetic AlterationsHIN-1: a New Epigenetic Biomarker Crucial for Therapy Selection in Glioblastoma Multiforme.25752997
TuberculosisEpigenetic AlterationsIdentification of miR-93 as a suitable miR for normalizing miRNA in plasma of tuberculosis patients.25753045
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsGSTP1 promoter hypermethylation was found as the earliest and a long-lasting epigenetic marker in blood samples of PCa patients, which makes it suitable as a marker for treatment follow-up.25753984
melanomaEpigenetic AlterationsThough rare, the identification of SMARCB1 mutations adds to the growing literature regarding the role of epigenetic control mechanisms in melanoma progression and therapeutic resistance and provide a rationale for strategies targeting such alterations (via chromatin remodeling agents) in clinical trials.25754356
Colorectal Cancer Pathway, Metastasis, Squamous cell carcinoma of esophagusEpigenetic AlterationsMiR-1179, a new identified miRNA highly associated with metastasis of colorectal cancer which was never reported in esophageal squamous cell carcinoma (ESCC).25755718
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are a class of small, non-coding RNAs, which have demonstrated to important gene regulators, and have critical roles in diverse biological processes including cancer cell proliferation.25755720
Liver carcinomaEpigenetic AlterationsMicroRNA-338-3p inhibits cell proliferation in hepatocellular carcinoma by target forkhead box P4 (FOXP4).25755720
Carcinoma of lung, Stomach Carcinoma, Colorectal Carcinoma, NeoplasmsEpigenetic AlterationsPrevious studies suggested microRNA-338-3p (miR-338-3p) was down-regulated and play tumor suppressor roles in gastric cancer, colorectal carcinoma and lung cancer.25755720
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsLong noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer.25755750
Malignant neoplasm of urinary bladderEpigenetic AlterationsLinc-UBC1, a recently identified long noncoding RNA, was initially found to be upregulated in bladder cancer.25755750
Glioblastoma Multiforme PathwayEpigenetic AlterationsDownregulation of microRNA-504 is associated with poor prognosis in high-grade glioma.25755767
Primary malignant neoplasm, Hypopharyngeal Squamous Cell Carcinoma, NeoplasmsEpigenetic AlterationsOn the other hand, a recent study revealed that miR-504 inhibits cancer cell proliferation through targeting CDK6 in hypopharyngeal squamous cell carcinoma (HSCC), suggesting the tumor suppressive role of this miRNA.25755767
NeoplasmsEpigenetic AlterationsRecent study indicated that microRNAs (miRNAs) played critical roles in tumor progression.25755771
Malignant NeoplasmsEpigenetic AlterationsMiRNAs are stable molecules in blood and used as biomarkers for the early diagnosis of various malignancy.25755772
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA CCAT2 is up-regulated in gastric cancer and associated with poor prognosis.25755774
NeoplasmsEpigenetic AlterationsDysregulation of long non-coding RNAs (lncRNAs) play important roles in tumor progression.25755774
Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA-106b (miR-106b) is thought to be an oncogenic microRNA that promotes tumor growth and metastasis.25755775
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-148b is down-regulated in non-small cell lung cancer and associated with poor survival.25755777
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIncreased expression of microRNA-150 is associated with poor prognosis in non-small cell lung cancer.25755784
Malignant Pleural MesotheliomaEpigenetic AlterationsSpecific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion.25756049
Glioblastoma MultiformeEpigenetic AlterationsDifferential expression of microRNAs in postoperative radiotherapy sensitive and resistant patients with glioblastoma multiforme.25758051
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in the initiation and progression of a multitude of tumors.25758051
Leukemia, Myelocytic, AcuteEpigenetic AlterationsUpregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients.25759982
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRs) have been shown to negatively regulate gene expression by binding to mRNAs, and they play an important role in various physiological processes and malignancies.25759982
Malignant NeoplasmsEpigenetic AlterationsCervical cancers exhibit aberrant cellular microRNA (miRNA) expression patterns.25760330
Primary malignant neoplasmEpigenetic AlterationsThe E6/E7-regulated miRNAs are enriched for species involved in the control of cell proliferation, senescence and apoptosis, suggesting that they contribute to the growth of HPV-positive cancer cells.25760330
Prostate Cancer PathwayEpigenetic AlterationsTo develop a microRNA (miRNA)-based predictive model for prostate cancer patients of 1) time to biochemical recurrence after radical prostatectomy and 2) biochemical recurrence after salvage radiation therapy following documented biochemical disease progression post-radical prostatectomy.25760964
Primary malignant neoplasmEpigenetic AlterationsRetinoid X receptor (RXR) and Histone deacetylase (HDAC) are considered important targets for cancer therapy due to their crucial roles in genetic or epigenetic regulations of cancer development and progression.25762635
Diffuse Large B-Cell Lymphoma, LymphomaEpigenetic AlterationsEnhancer of Zeste Homolog 2 (EZH2) plays an essential epigenetic role in Diffuse Large B Cell Lymphoma (DLBCL) development.25762637
Pulmonary HypertensionEpigenetic AlterationsDiscordant Regulation of microRNA Between Multiple Experimental Models and Human Pulmonary Hypertension.25763574
Pulmonary arterial hypertension, 4-aminohippuric acidEpigenetic AlterationsThe dysregulation of microRNA (miRNA) is known to contribute to the pathobiology of pulmonary arterial hypertension (PAH).25763574
Pulmonary HypertensionEpigenetic AlterationsHowever, the relationships between changes in tissue and circulating miRNA levels associated with different animal models and human pulmonary hypertension (PH) have not been defined.25763574
HypoxiaEpigenetic AlterationsA set of miRNAs that have been causally implicated in PH, including miR-17, -21, -130b, -145, -204, -424, and -503, were measured by reverse transcription-quantitative polymerase chain reaction in the plasma, lung, and right ventricle of three of the most common rodent models of PH: the rat monocrotaline and SU5416 plus chronic hypoxia (SuHx) models and the mouse chronic hypoxia model.25763574
Disease, Cardiovascular DiseasesEpigenetic AlterationsIn addition, microRNAs have been implicated in the pathogenesis of a large number of diseases, including cardiovascular diseases, and are considered as promising candidate biomarkers due to their relative stability and easy quantification from clinical samples.25763857
Heart failureEpigenetic AlterationsHowever, several previously identified heart failure marker microRNAs were detected.25763857
Carcinoma of lungEpigenetic AlterationsExpression and significance of circulating microRNA-31 in lung cancer patients.25765717
Carcinoma of lungEpigenetic AlterationsReal-time fluorescent quantitative PCR was utilized to detect the circulating miRNA-31 expression levels in 300 lung cancer patients and 300 health control subjects.25765717
Carcinoma of lungEpigenetic AlterationsThe 300 lung cancer patients were divided into a miRNA-31 low-expression group and a miRNA-31 high-expression group.25765717
Carcinoma of lungEpigenetic AlterationsThe circulating miRNA-31 expression levels in the lung cancer patients (l.88+-0.25765717
Carcinoma of lungEpigenetic AlterationsWhen the critical value was 1.27, the sensitivity and specificity for lung cancer diagnosis according to the circulating miRNA-31 expression levels were 0.769 and 0.745, respectively.25765717
Primary malignant neoplasmEpigenetic AlterationsmiRNA-31 may be a molecular marker for the diagnostic and prognostic evaluation of primary lung cancer.25765717
Dengue FeverEpigenetic AlterationsTime since onset of disease and individual clinical markers associate with transcriptional changes in uncomplicated dengue.25768297
AdenomaEpigenetic AlterationsDifferences in miRNA levels between the nonadvanced adenoma group and controls were modest.25770825
Clinical Coordinator, Colorectal NeoplasmsEpigenetic AlterationsOur study found that expression of many miRNAs in serum was inversely correlated with the severity of colorectal neoplasia, and differential miRNA profiles were apparent in preneoplastic cases with advanced lesions, suggesting circulating miRNAs could serve as potential biomarkers for CRC screening.25770825
Colorectal NeoplasmsEpigenetic AlterationsDifferential expression of circulating microRNAs according to severity of colorectal neoplasia.25770825
Clinical Coordinator, Neoplastic disease, AdenomaEpigenetic AlterationsOf the 175 miRNAs, 106 miRNAs were downregulated according to severity of neoplasia and showed a relative decrease in the expression from controls to nonadvanced adenoma to advanced adenoma to CRC (Ptrend < 0.05).25770825
Clinical Coordinator, AdenomaEpigenetic AlterationsPairwise group comparisons showed that 39 and 80 miRNAs were differentially expressed in the advanced adenoma and CRC groups compared with the controls, respectively.25770825
Malignant NeoplasmsEpigenetic AlterationsGlobal miRNA expression profile has been widely used to characterize human cancers.25771723
Gastric AdenocarcinomaEpigenetic AlterationsGenome-wide miRNA microarray was employed for assessment of miRNA expression profile of gastric adenocarcinoma (GAC).25771723
GliomaEpigenetic AlterationsCorrelation of microRNA-10b upregulation and poor prognosis in human gliomas.25773393
Stage II Colorectal CancerEpigenetic AlterationsMicroRNA expression profile in patients with stage II colorectal cancer: a Turkish referral center study.25773836
Colorectal Cancer PathwayEpigenetic AlterationsThere are increasing data about microRNAs (miRNA) in the literature, providing abundant evidence that they play important roles in pathogenesis and development of colorectal cancer.25773836
Malignant tumor of colonEpigenetic AlterationsExpression of 16 miRNAs (miRNA-9, 21, 30d, 31, 106a, 127, 133a, 133b, 135b, 143, 145, 155, 182, 200a, 200c, 362) was verified by quantitative real-time polymerase chain reaction (qRT-PCR) in all resected colon cancer tissue samples and in corresponding normal colonic tissues.25773836
Primary malignant neoplasmEpigenetic AlterationsWhen we compared subgroups, miRNA expression profiles of 20 recurrent cancer tissues were similar to all 40 cancer tissues.25773836
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsThese miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.25773836
Breast CarcinomaEpigenetic AlterationsTo identify a prognostic signature for breast cancer, we performed DNA methylation profiling and identified methylation markers that were associated with expression of ER, PR, HER2, CK5/6, and EGFR proteins.25773928
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThese results suggest that integrated analysis of tumor expression markers, DNA methylation, and mRNA data may be an important approach for identifying breast cancer prognostic signatures.25773928
Hollings Cancer CenterEpigenetic AlterationsResearches have shown that miRNAs have been proposed as novel diagnostic biomarkers for classification and prognostic stratification of HCC.25775917
Malignant Neoplasms, MetastasisEpigenetic AlterationsmiR-338-3p, a recently discovered miRNA, has been shown to play important roles in tumorigenesis and metastasis in various cancers.25776272
Malignant NeoplasmsEpigenetic AlterationsThe DNA methylation alterations occurring in human cancers have two types: global DNA hypomethylation and site-specific CpG island promoter hypermethylation.25782871
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsLINE-1 methylation in the noncancerous gastric mucosae of gastric cancer patients was significantly higher than in cancer tissues (P = 0.0006), but significantly lower than in the gastric mucosae of the autopsied individuals (P = 0.026), suggesting the formation of epigenetic field defect in noncancerous gastric mucosae.25782871
Infection caused by Helicobacter pylori, Stomach CarcinomaEpigenetic AlterationsLINE-1 hypomethylation of gastric mucosae significantly correlated with H. pylori infection, supporting the potential of LINE-1 methylation level as a surrogate marker of epigenetic field defects for gastric cancer cancerization, particularly induced by H. pylori.25782871
Triple-Negative Breast Cancer Finding, NeoplasmsEpigenetic AlterationsHere we demonstrated that epigenetic alteration of key tumor suppressor gene can be a promising biomarker for the prognosis of triple-negative breast cancer/basal-like breast cancer.25783183
Dysplasia, SERPINB3 wt AlleleEpigenetic AlterationsThe only microRNA to discriminate between OSCC and PMD with dysplasia was miRNA-184.25784212
SERPINB3 wt AlleleEpigenetic AlterationsConversely, miRNA-145 levels showed a highly significant decrease in OSCC and PMD overall (P < 0.001).25784212
Oral mucosal lesions, S100A4 protein, humanEpigenetic AlterationsSalivary determination of the miRNAs tested might furnish a noninvasive, rapid adjunctive aid for revealing malignant transformation in oral mucosal lesions, particularly miRNA-184.25784212
Primary malignant neoplasmEpigenetic AlterationsSalivary microRNAs in oral cancer.25784212
Barrett EsophagusEpigenetic AlterationsDynamic changes in microRNA expression profiles reflect progression of Barretts esophagus to esophageal adenocarcinoma.25784377
CarcinogenesisEpigenetic AlterationsWe suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barretts-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC.25784377
MetastasisEpigenetic AlterationsUnexpectedly, we identified that miRNA-29b expression was elevated in the serum of NPC patients with a high risk of metastasis.25786138
Breast CarcinomaEpigenetic AlterationsUnsupervised and supervised comparison of gene and microRNA (miRNA) profiles of Chinese and Caucasian samples revealed extensive similarity in the comprehensive taxonomy of transcriptional elements regulating breast cancer biology.25787708
Breast CarcinomaEpigenetic AlterationsPartition of gene expression data using gene lists relevant to breast cancer as "intrinsic" and "extracellular matrix" genes identified Chinese and Caucasian subgroups with equivalent global gene and miRNA profiles.25787708
Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsRecently, cancer relevant miRNAs deregulated during disease progression have also been identified in tumor-associated stroma.By combining laser-microdissection (LMD) with high-throughput screening and high-sensitivity quantitation techniques, miRNA expression in colorectal cancer (CRC) specimens and paired normal colonic tissue was independently characterized in stromal and epithelial tissue compartments.25788261
Colorectal Cancer PathwayEpigenetic AlterationsStratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs.25788261
Clinical Coordinator, Phenomenon, NeoplasmsEpigenetic AlterationsNotably, deregulation of the key oncogene miR-21 was identified exclusively as a stromal phenomenon and miR-106a, an epithelial phenomenon in the malignant state.MiRNAs identified in this study successfully distinguished CRC from normal tissue and metastatic from non-metastatic tumor specimens.25788261
Clinical Coordinator, NeoplasmsEpigenetic AlterationsDFS: HR = 5.83, p = 0.002; OS: HR = 4.13, p = 0.007).These data support the notion that stromal as well as epithelial miRNAs play important roles during disease progression, and that mapping patterns of deregulated gene expression to the appropriate tumor strata may be a valuable aid to therapeutic decision making in CRC.25788261
Breast Carcinoma, NeoplasmsEpigenetic AlterationsAberrant DNA methylation that leads to the inactivation of tumor suppressor genes is known to play an important role in the development and progression of breast cancer.25789956
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small, non-coding RNAs that may function as oncogenes or tumor suppressors.25791131
Squamous cell carcinomaEpigenetic AlterationsExpression and clinical significance of microRNA-1246 in human oral squamous cell carcinoma.25791131
Carcinoma, NeuroendocrineEpigenetic AlterationsOur findings demonstrate that lung carcinoids have distinct microRNA expression profiles as compared to high-grade neuroendocrine carcinomas and that specific microRNAs might have potential implications as diagnostic tools or clinical biomarkers.25791280
Carcinoid TumorEpigenetic AlterationsIdentification of MicroRNAs Differentially Expressed in Lung Carcinoid Subtypes and Progression.25791280
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miR)-486-5p expression is often reduced in human cancers.25793394
NRAS gene, KRAS protein, humanEpigenetic AlterationsWe also tested the specimens for KRAS, NRAS, BRAF and PIK3CA mutations and measured microRNA-21 and microRNA-31.25797243
Renal Cell Carcinoma PathwayEpigenetic AlterationsInactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways.25797254
Colorectal Cancer PathwayEpigenetic AlterationsRole of microRNA-30c targeting ADAM19 in colorectal cancer.25799050
Malignant Neoplasms, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNAs (miRNAs) are deregulated in a number of cancers including colorectal cancer.25799050
Epilepsy, Temporal LobeEpigenetic AlterationsDynamic Expression of MicroRNAs (183, 135a, 125b, 128, 30c and 27a) in the Rat Pilocarpine Model and Temporal Lobe Epilepsy Patients.25801837
Epilepsy, Temporal LobeEpigenetic AlterationsRecently, microRNAs (miRNAs) are emerging as new regulators in the pathogenesis of temporal lobe epilepsy (TLE) and playing a major role in the inflammatory and immune processes.25801837
Adenocarcinoma of large intestineEpigenetic AlterationsIdentification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.25803870
Clinical CoordinatorEpigenetic AlterationsMicroRNAs are thought to be potential biomarkers of CRC.25803870
Clinical CoordinatorEpigenetic AlterationsMany researchers have focused on the expression pattern of miRNAs in CRC.25803870
Adenocarcinoma of large intestineEpigenetic AlterationsIn all, 93 miRNAs were identified that were significantly dysregulated in Colorectal adenocarcinoma relative to normal tissues (P<0.05).25803870
Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsThen, we analyzed their potential as cancer biomarkers by ROC analysis, and the result revealed that three miRNAs with high sensitivity and specificity are suitable as biomarkers for the diagnosis of CRC (the value of the AUC was greater than 0.7).25803870
Malignant NeoplasmsEpigenetic AlterationsFurthermore, we wanted to analyze the difference between well- and moderately differentiated cancers, and as expected, 58 miRNAs showed significant dysregulation.25803870
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsImportantly, 32 miRNAs were able to not only distinguish cancer tissues from normal tissues, but they were also able to identify well- and moderately differentiated cancers.25803870
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTo avoid misdiagnoses and missed diagnoses, tumors of different degrees of differentiation should be treated differently when miRNAs are used as cancer biomarkers.25803870
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers.25804630
Primary malignant neoplasmEpigenetic AlterationsEpigenetic modification of cancer cell genome is often linked to the expression of important cancer-related genes.25806852
Clinical CoordinatorEpigenetic AlterationsStable presence of miRNAs in serum enables them to be biomarkers for early diagnosis and surveillance of the progress of CRC.25807655
SepticemiaEpigenetic AlterationsRecent reports on alterations in miR-223 serum levels during sepsis revealed contradictory results, preventing a potential use of this miRNA in clinical routine.25810564
Refractory Cytopenia of Childhood, Renal Cell Carcinoma PathwayEpigenetic AlterationsThe miRNA, miR-134, has been found to be downregulated in renal cell carcinoma (RCC), but its function in the disease is unknown.25811077
Malignant NeoplasmsEpigenetic AlterationsAberrant microRNAs (miRNAs) are reported to contribute to the pathogenesis of most human malignancies.25811077
Esophageal carcinomaEpigenetic AlterationsSerum microRNA-218 is a potential biomarker for esophageal cancer.25812647
Esophageal carcinomaEpigenetic AlterationsThe expression of microRNA-218 (miR-218) is downregulated in esophageal cancer as reported in previous research.25812647
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsImpairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines.25814674
Idiopathic pulmonary hypertensionEpigenetic AlterationsRole of circulating miRNAs as biomarkers in idiopathic pulmonary arterial hypertension: possible relevance of miR-23a.25815108
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRs) are small, endogenous noncoding RNAs that serve a significant function in various biologic processes, including those involved in cancer.25815587
Renal Cell Carcinoma PathwayEpigenetic AlterationsUpregulated microRNA-16 as an oncogene in renal cell carcinoma.25815587
Primary malignant neoplasmEpigenetic AlterationsDNA methylation combinations in adjacent normal colon tissue predict cancer recurrence: evidence from a clinical cohort study.25815725
Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsWe evaluate the combination of cancer stage and DNA methylation status as an indicator of the risk of recurrence and mortality among patients with colorectal cancer (CRC).25815725
NeoplasmsEpigenetic AlterationsFor combined analyses, the risk of recurrence in the patients in advanced stage with DNA methylation in both normal and tumor tissues, compared with local stage with unmethylation, was increased with adjusted HR (95% CI) of 9.37 (3.36-26.09).25815725
Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsThis study demonstrates that clustering DNA methylation status according to cancer stage and tissue subtype is critical for the assessment of risk of recurrence in CRC patients and also indicated an underlying mechanism.25815725
Liver carcinoma, NeoplasmsEpigenetic AlterationsDNA methylation consistency implicates the primary tumor cell origin of recurrent hepatocellular carcinoma.25815780
NeoplasmsEpigenetic AlterationsSimilar DNA methylation patterns were observed among nine of ten pairs of primary and recurrent tumors.25815780
Liver diseasesEpigenetic AlterationsSerum microRNA-125a-5p, a useful biomarker in liver diseases, correlates with disease progression.25815788
Liver carcinoma, Liver diseases, Hollings Cancer Center, Fibrosis AssessmentEpigenetic AlterationsIt has been demonstrated that liver microRNA-125a-5p (miR-125a-5p) is correlated with disease progression in different liver diseases, including liver fibrosis and hepatocellular carcinoma (HCC).25815788
Admitting diagnosisEpigenetic AlterationsThe epigenetic mechanism of BDNF methylation may be responsible for the reduced expression of BDNF in patients with AD.25815896
Diabetes Mellitus, Non-Insulin-Dependent, square decimeterEpigenetic AlterationsMicroRNA-103 (miR-103) plays a critical role in regulating glucose homeostasis in type 2 diabetes (DM2).25820527
NeoplasmsEpigenetic AlterationsHowever, the proliferation rate of tumor cells was reduced in the absence of RORgt-dependent Th17 cells and tumor cells showed pronounced signs of senescence-associated epigenetic and lysosomal changes.25820779
Primary malignant neoplasmEpigenetic AlterationsEpigenetic mechanisms such as DNA methylation are being increasingly recognized to play an important role in cancer and may serve as a cancer biomarker.25820821
MYELODYSPLASTIC SYNDROME, Leukemia, Myelomonocytic, ChronicEpigenetic AlterationsMyelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic modifiers and aberrant DNA methylation.25822018
Primary malignant neoplasmEpigenetic AlterationsNuclear corepressor (NCoR) is an essential regulator of gene transcription, and its function has been found deregulated in different types of cancer.25823659
ChordomaEpigenetic AlterationsMicroRNA-155 expression is independently predictive of outcome in chordoma.25823817
ChordomaEpigenetic AlterationsThe miRNA microarray assay revealed miR-155 to be highly expressed and biologically active in chordoma.25823817
Breast CarcinomaEpigenetic AlterationsLoss of expression of cyclin d2 by aberrant DNA methylation: a potential biomarker in vietnamese breast cancer patients.25824739
cell transformation, NeoplasmsEpigenetic AlterationsDNA methylation of tumor suppressor gene promoters is the most frequent phenomenon leading to inactivation of function, consequently driving malignant cell transformation.25824739
Endometrial CarcinomaEpigenetic AlterationsUrine has been shown as the source of microRNAs several years ago; however, there has been lack of information on urine microRNA expression in ovarian and endometrial cancers till now.25827090
Endometrial CarcinomaEpigenetic AlterationsEvaluation of Cell-Free Urine microRNAs Expression for the Use in Diagnosis of Ovarian and Endometrial Cancers.25827090
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is an important epigenetic modification that is frequently altered in cancer.25827305
ovarian neoplasmEpigenetic AlterationsThe influence of DNA methylation in epithelial ovarian cancer (EOC) is not fully understood.25827305
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDNA methylation occurs commonly in non-small cell lung cancer (NSCLC).25828518
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer.25828518
Psoriatic Juvenile Idiopathic ArthritisEpigenetic AlterationsCorrelation between Reversal of DNA Methylation and Clinical Symptoms in Psoriatic Epidermis Following Narrow-Band UVB Phototherapy.25830654
PsoriasisEpigenetic AlterationsGenome-wide DNA methylation profiling of epidermal cells from 12 patients undergoing narrow-band UVB phototherapy and 12 corresponding healthy controls revealed a distinct DNA methylation pattern in psoriasis compared with controls.25830654
PsoriasisEpigenetic AlterationsOur study identified key epigenetic events associated with psoriasis pathogenesis and helps understand the dynamic DNA methylation landscape in the human genome.25830654
Liver carcinoma, CholangiocarcinomaEpigenetic AlterationsGlobal DNA methylation and hydroxymethylation differ in hepatocellular carcinoma and cholangiocarcinoma and relate to survival rate.25833413
Primary malignant neoplasmEpigenetic AlterationsmicroRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression.25833694
Weight decreased, Breast CarcinomaEpigenetic AlterationsDietary modifications, weight loss, and changes in metabolic markers affect global DNA methylation in Hispanic, African American, and Afro-Caribbean breast cancer survivors.25833781
Primary malignant neoplasmEpigenetic AlterationsLower levels of global DNA methylation in tissue and blood have been associated with increased cancer risk.25833781
Weight decreasedEpigenetic AlterationsIn this trial, we explored the associations between changes in lifestyle modifications (diet, weight loss), metabolic markers, and global epigenetic biomarkers in white blood cells.25833781
Primary malignant neoplasmEpigenetic AlterationsAn increasing body of evidence has indicated that polymorphisms in the miRNA binding site of target gene can alter the ability of miRNAs to bind their target genes and modulate the risk of cancer.25834816
Stomach CarcinomaEpigenetic AlterationsLong noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer.25835973
Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (lncRNAs) are emerging as novel regulators in the cancer paradigm.25835973
Degenerative polyarthritis, Arthritis, Rheumatoid Arthritis, Right armEpigenetic AlterationsSingle-nucleotide polymorphisms (SNPs) in miRNA sequences may alter miRNA expression and have been implicated in the pathogenesis of multiple forms of arthritis, including rheumatoid arthritis (RA) and osteoarthritis.25836258
Breast CarcinomaEpigenetic AlterationsGlobal Transcriptional Changes Following Statin Treatment in Breast Cancer.25840970
ovarian neoplasmEpigenetic AlterationsLong non-coding RNA ANRIL predicts poor prognosis and promotes invasion/metastasis in serous ovarian cancer.25845387
Colorectal Cancer PathwayEpigenetic AlterationsScreening and preliminary validation of miRNAs with the regulation of hTERT in colorectal cancer.25845814
Clinical CoordinatorEpigenetic AlterationsThe expression of miRNAs candidates was verified by quantitative polymerase chain reaction in the CRC and corresponding normal tissues.25845814
Conventional (Clear Cell) Renal Cell Carcinoma, Primary malignant neoplasmEpigenetic AlterationsmiR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W. Increasing evidence has demonstrated that small non-coding microRNAs (miRNAs) play important roles in cancer development and progression.25846734
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation is an epigenetic event that occurs frequently in colorectal cancer (CRC).25846879
Atypical Reparative CellEpigenetic AlterationsDNA methylation of MGMT may regulate the expression of the gene and be involved in the development of ARC.25847269
Primary malignant neoplasmEpigenetic AlterationsBioinformatical analysis revealed that the potential target genes of these miRNAs were mainly involved in gene transcription, cell junction proteins, and gene pathways in cancer and endocytosis.25850393
ChordomaEpigenetic AlterationsReduced expression of miRNA-1237-3p associated with poor survival of spinal chordoma patients.25850393
ChordomaEpigenetic AlterationsA miRNA array was used to profile differentially expressed miRNAs in spinal chordoma and nucleus pulposus tissues.25850393
ChordomaEpigenetic AlterationsThe miRNA arrays identified 29 differentially expressed miRNAs in spinal chordoma tissues, four of which were verified by qRT-PCR in 42 spinal chordomas and 14 control tissues.25850393
ChordomaEpigenetic AlterationsFour of these differentially expressed miRNAs was then validated in spinal chordoma and control patients using quantitative RT-PCR.25850393
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe serum free deoxyribose nucleic acid (DNA) methylation spectrum of EOC patients was completely contained in the DNA spectrum of cancer tissues, providing an accurate reflection of tumor DNA methylation conditions.25854397
Coronary Artery DiseaseEpigenetic AlterationsA comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease.25856389
ArteriosclerosisEpigenetic AlterationsSo far, our current knowledge of the DNA methylation profiles for atherosclerosis affected and healthy human vascular tissues is still limited.25856389
Coronary Artery DiseaseEpigenetic AlterationsThe DNA methylation differences observed in vascular tissues of patients with coronary heart disease can provide new insights into the mechanisms underlying the development of pathology and explanation for the difference in graft patency after coronary artery bypass grafting surgery.25856389
Cardiovascular DiseasesEpigenetic AlterationsEpigenetic mechanisms of gene regulation in context of cardiovascular diseases are of considerable interest.25856389
Schizophrenia, Bipolar Disorder, Mental disorders, Primary malignant neoplasmEpigenetic AlterationsRecent evidence supports a role of microRNAs in cancer and psychiatric disorders such as schizophrenia and bipolar disorder, through their regulatory role on the expression of multiple genes.25856466
Schizophrenia, Mental disorders, Primary malignant neoplasmEpigenetic AlterationsThe rather rare co-morbidity of cancer and schizophrenia is an old hypothesis which needs further research on microRNAs as molecules that might exert their oncosuppressive or oncogenic activity in the context of their role in psychiatric disorders.25856466
GainEpigenetic AlterationsTargeting miRNAs by gain or loss of function approaches have brought therapeutic effects in various disease models.25860297
Stomach CarcinomaEpigenetic AlterationsEpigenetic modification plays pivotal roles in gastric cancer development.25860861
Stomach CarcinomaEpigenetic AlterationsInterference with the b-catenin gene in gastric cancer induces changes to the miRNA expression profile.25861021
Gallbladder CarcinomaEpigenetic AlterationsThus, the miRNA profiles could play essential roles in gallbladder cancer (GBC).25861754
NeoplasmsEpigenetic AlterationsOur results suggest a possible pathological relationship between the differential expression of miRNA in peripheral blood and GBC, and these dysregulated miRNAs could be novel tumor biomarkers for early detection of GBC.25861754
Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Primary malignant neoplasmEpigenetic AlterationsOur results highlight the impact of age, BMI and HbA1c on epigenetic variation of candidate genes for obesity, type 2 diabetes and cancer in human adipose tissue.25861810
Metastasis, Pituitary carcinomaEpigenetic AlterationsOur results suggest microRNA involvement in malignant pituitary progression, whereby increased miR-20a, miR-106b and miR-17-5p promote metastasis by attenuating PTEN and TIMP2 in pituitary carcinoma.25862551
Non-Small Cell Lung CarcinomaEpigenetic AlterationsNon-small cell lung cancer detection using microRNA expression profiling of bronchoalveolar lavage fluid and sputum.25862841
Non-Small Cell Lung CarcinomaEpigenetic AlterationsTo assess if miRNA expression profiling of bronchoalveolar lavage (BAL) fluid and sputum could be used to detect early-stage non-small cell lung cancer (NSCLC).25862841
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC.25862841
LymphadenitisEpigenetic AlterationsAs a first step towards understanding the possible influence of microRNA-dysregulation in AITL, we analyzed the expression signatures of 760 microRNAs in 30 nodal AITLs in comparison to reactive lymphadenitis with T-zone hyperplasia.25862860
Angioimmunoblastic LymphadenopathyEpigenetic AlterationsDysregulation of microRNAs in angioimmunoblastic T-cell lymphoma.25862860
Squamous cell carcinoma of the head and neckEpigenetic AlterationsMicroRNA profile in site-specific head and neck squamous cell cancer.25862914
Oropharyngeal Route of Drug AdministrationEpigenetic AlterationsThe microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC.25862914
Bone DiseasesEpigenetic AlterationsAccumulating evidence has recently indicated a vital role of microRNAs (miRNAs) in the development of various bone diseases.25863178
Metastasis, Adenocarcinoma of lung (disorder)Epigenetic AlterationsThe long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma.25863539
NeoplasmsEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have emerged as key regulators of tumor development and progression.25863539
B-Cell LymphomasEpigenetic AlterationsUpregulation of long noncoding RNA PEG10 associates with poor prognosis in diffuse large B cell lymphoma with facilitating tumorigenicity.25864113
InitiationEpigenetic AlterationsEmerging evidences have implicated that long noncoding RNAs (lncRNAs) have important regulatory roles in fundamental biological processes, and some of them are involved in cancer initiation, development and progression.25864113
Breast CarcinomaEpigenetic AlterationsPrognostic and predictive values of long non-coding RNA LINC00472 in breast cancer.25865225
Breast Carcinoma, Mammary NeoplasmsEpigenetic AlterationsEvaluating this long non-coding RNA in breast tumors may have prognostic and predictive value in the clinical management of breast cancer.25865225
Diffuse Large B-Cell LymphomaEpigenetic AlterationsTo compare microRNA (miR) expression between patients with diffuse large B-cell lymphoma (DLBCL) who had a poor prognosis to those who had a favorable prognosis.25866097
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA expression signatures can promote personalised care for non-small cell lung cancer (NSCLC) patients.25867273
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsC/EBP-b-activated microRNA-223 promotes tumour growth through targeting RASA1 in human colorectal cancer.25867276
melanomaEpigenetic AlterationsWe analyzed the effect of cordycepin on human melanoma miRNA expression profiles by miRNAarray and found that miR-33b was upregulated in highly-metastatic melanoma cell lines following cordycepin exposure.25868853
melanoma, Neoplasm MetastasisEpigenetic AlterationsWe showed for the first time that targeting miRNA by cordycepin indicates a new mechanism of cordycepin-induced suppression of tumor metastasis and miR-33b/HMGA2/Twist1/ZEB1 axis plays critical roles in regulating melanoma dissemination.25868853
Occult Lung Non-Small Cell CarcinomaEpigenetic AlterationsPrognostic value of microRNA-10b overexpression in peripheral blood mononuclear cells of nonsmall-cell lung cancer patients.25869877
Occult Lung Non-Small Cell Carcinoma, Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe examined microRNA (miRNA)-10b expression in peripheral blood mononuclear cells (PBMCs) of nonsmall-cell lung cancer (NSCLC) patients for its clinical value.25869877
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe correlation between miRNA-10b expression levels and the clinical and pathological characteristics of NSCLC was obtained.25869877
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMiRNA-10b expression levels in PBMCs can distinguish NSCLC patients from cancer-free subjects with a high sensitivity and specificity, suggesting that miRNA-10b expression in PBMCs is a valuable diagnostic and prognostic marker in NSCLC.25869877
Acute intermittent porphyriaEpigenetic AlterationsOur results identified that miRNAs were differentially expressed in the serum of AIP patients.25871699
Platinum-Resistant Ovarian Carcinoma, ovarian neoplasmEpigenetic AlterationsMicroRNA signatures of platinum-resistance in ovarian cancer.25872328
ovarian neoplasmEpigenetic AlterationsThe authors utilized a microRNA (miRNA) array to compare the differentially expressed miRNAs in platinum-resistant associated ovarian cancer cells.25872328
ovarian neoplasmEpigenetic AlterationsThe authors identified that several miRNAs are altered in collected 86 samples of human ovarian cancer cell-lines, with four significantly deregulated miRNAs and 13 upregulated miRNAs.25872328
Malignant Neoplasms, Late stage, MetastasisEpigenetic AlterationsAs patient survival drops precipitously from early-stage cancers to late-stage and metastatic cancers, microRNAs that promote relapse and metastasis can serve as prognostic and predictive markers as well as therapeutic targets for chemoprevention.25872451
Prostate Cancer PathwayEpigenetic AlterationsElevated serum microRNA levels associate with absence of high-grade prostate cancer in a retrospective cohort.25874774
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsCirculating microRNAs (miRNAs) are stable serum markers and differential miRNA levels occur in men with PCa.25874774
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe expression levels of the 14 miRNAs were combined into a "miR Score" which had a negative predictive value (NPV) of 0.939 to predict absence of high-grade PCa among PCa and BPH patients.25874774
Aggressive behaviorEpigenetic AlterationsIn summary, measurement of serum miRNAs may have pre-surgical utility in combination with clinical risk calculators to identify patients with low risk of harboring aggressive PCa.25874774
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-138-5p regulates pancreatic cancer cell growth through targeting FOXC1.25875420
Neoplasm MetastasisEpigenetic AlterationsEnhancer of zeste homolog 2 (EZH2), a polycomb histone methyltransferase, is a key epigenetic modifier implicated in various cancer metastasis.25877750
Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNA-223 is a novel negative regulator of HSP90B1 in CLL.25880332
Chronic Lymphocytic LeukemiaEpigenetic AlterationsHowever, there is no evidence of the pathogenetic mechanism of this miRNA in CLL patients.25880332
Malignant Neoplasms, cervical cancerEpigenetic AlterationsOur observations provide an important cautionary tale for future miRNA signature studies for cervical cancer, which can also be potentially applicable to miRNA profiling studies involving other types of human malignancies.25880806
Cervix carcinomaEpigenetic AlterationsDeveloping a prognostic micro-RNA signature for human cervical carcinoma.25880806
cervical cancerEpigenetic AlterationsWe sought to develop a micro-RNA signature that was prognostic for disease-free survival, which could potentially allow tailoring of treatment for cervical cancer patients.25880806
cervical cancer, NeoplasmsEpigenetic AlterationsThere are several challenges and considerations associated with developing a prognostic micro-RNA signature for cervical cancer, namely: tumour heterogeneity, lack of concordance between frozen and FFPE specimens, and platform selection for global micro-RNA expression profiling in this disease.25880806
Intrahepatic CholangiocarcinomaEpigenetic AlterationsIdentification of a novel microRNA signature associated with intrahepatic cholangiocarcinoma (ICC) patient prognosis.25880914
Intrahepatic bile duct, Development International Birth DateEpigenetic AlterationsUsing a custom microarray containing 1,094 probes, the miRNA expression profiles of 63 human ICCs and nine normal intrahepatic bile ducts (NIBD) were assessed.25880914
Development International Birth DateEpigenetic AlterationsFrom the 158 differentially expressed miRNAs, a 30-miRNA signature consisting of 10 up-regulated and 20 down-regulated miRNAs in ICC was established for distinguishing ICC from NIBD with 100% accuracy.25880914
Intrahepatic CholangiocarcinomaEpigenetic AlterationsThe clinical significance of microRNAs (miRNAs) in intrahepatic cholangiocarcinoma (ICC) is unclear.25880914
Development International Birth DateEpigenetic AlterationsExpression profile analysis showed 158 differentially expressed miRNAs between ICC and NIBD, with 77 up-regulated and 81 down-regulated miRNAs.25880914
Carcinoma of lung, NeoplasmsEpigenetic AlterationsMicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3.25881295
Coronary Artery DiseaseEpigenetic AlterationsAn Association between MicroRNA-21 Expression and Vitamin D Deficiency in Coronary Artery Disease.25882990
Triple-Negative Breast Cancer FindingEpigenetic AlterationsmicroRNA (miRNA) and protein expression profiles were obtained from 71 estrogen receptor-positive (ER(+)) and 25 triple-negative breast cancer (TNBC) samples.25883093
Breast CarcinomaEpigenetic AlterationsThe integration of miRNA and protein expression data unravels molecular processes that can be related to differences in the genesis and clinical evolution of these types of breast cancer.25883093
Malignant neoplasm of urinary bladderEpigenetic AlterationsLoss of expression of miRNA-141 and miRNA-200b was associated with increased invasion and migration ability, upregulated MMP-2, MMP-9, vimentin and N-cadherin expression, and downregulated E-cadherin expression in bladder cancer cell lines.25884322
MetastasisEpigenetic AlterationsUrine miRNA-141 and miRNA-200b levels could discriminate patients with lymph node metastasis from those who were lymph node negative (AUC: 0.704 and 0.674, respectively).25884322
Malignant neoplasm of urinary bladderEpigenetic AlterationsMiRNA-141 and miRNA-200b play important roles in the invasive ability and EMT phenotype of bladder cancer.25884322
MetastasisEpigenetic AlterationsDetection of miRNA-141 and miRNA-200b can help to identify patients undergoing cystectomy who are likely to have lymph node metastasis, and therefore those who may benefit from super-extended PLND.25884322
Liver carcinomaEpigenetic AlterationsLong noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge.25884472
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have been identified as having functional roles in cancer biology and are deregulated in many cancers.25884472
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis.25885099
melanomaEpigenetic AlterationsOur genome-wide DNA methylation and gene expression study of 10 early passage melanoma cell cultures reveals two phenotypically distinct groups.25885555
ibudilastEpigenetic AlterationsThe role of microRNAs (miRNAs), noncoding RNAs involved in regulating numerous biological processes, to IBD pathology, in terms of initiation and progression, remains ill-defined.25886994
Ulcerative Colitis, Crohn DiseaseEpigenetic AlterationsMicroRNA signatures differentiate Crohns disease from ulcerative colitis.25886994
Ulcerative ColitisEpigenetic AlterationsOur results suggest that there is specific miRNA expression patterns associated with UC versus CD in three separate tissue/body fluids (colon, blood, and saliva).25886994
ibudilast, InflammationEpigenetic AlterationsFurther, the aberrant miRNA expression profiles indicate that miRNAs may be contributory to IBD pathogenesis, or at least reflect the underlying inflammation.25886994
ibudilastEpigenetic AlterationsScrutinizing miRNA expression in saliva and blood samples may be beneficial in monitoring or diagnosing disease in IBD patients.25886994
Ulcerative ColitisEpigenetic AlterationsCD was associated with the differential expression of 10 miRNAs while UC was associated with 6 miRNAs in matched colon tissues.25886994
Ulcerative ColitisEpigenetic AlterationsCD was associated with altered expression of 6 miRNAs while UC was associated with 9 miRNAs in whole blood.25886994
Ulcerative ColitisEpigenetic AlterationsA panel of miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-146a, and miR-375) may be used as markers to identify and discriminate between CD and UC.25886994
Carcinoma, Ovarian EpithelialEpigenetic AlterationsmiRNA-1307 was up-regulated in the chemoresistant epithelial ovarian cancer tissues compared to the chemosensitive counterparts.25887170
ovarian neoplasm, Metastasis, NeoplasmsEpigenetic AlterationsThe up-regulation of miRNA-1307 was not associated with menopause, tumor differentiation state, clinical stage, and lymph node metastasis of ovarian cancer.25887170
ovarian neoplasmEpigenetic AlterationsOur results suggest that miRNA-1307 may play a role in the development of chemoresistance in ovarian cancer.25887170
Breast Carcinoma, MetastasisEpigenetic AlterationsLong non-coding RNA expression profiles predict metastasis in lymph node-negative breast cancer independently of traditional prognostic markers.25887545
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-184 inhibits cell proliferation and invasion, and specifically targets TNFAIP2 in Glioma.25888093
Squamous cell carcinoma, Liver carcinoma, NeoplasmsEpigenetic AlterationsmiRNA-184 is an oncogene in human hepatocellular carcinoma but acts as a tumor suppressor in tongue squamous cell carcinoma.25888093
ParesisEpigenetic AlterationsWe hypothesised that certain plasma microRNAs could be biomarkers of ICU acquired muscle weakness.25888214
CarcinogenesisEpigenetic AlterationsDysregulation of microRNAs (miRs) is involved in carcinogenesis.25888635
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are short, non-coding RNA molecules that play critical roles in human malignancy.25888956
Triple-Negative Breast Cancer FindingEpigenetic AlterationsOur work delivers a clear picture of the global miRNA regulatory characteristics in triple-negative breast cancer and extends the current knowledge of microRNA regulatory network.25888956
Triple-Negative Breast Cancer FindingEpigenetic AlterationsWe documented the evidence of seven polycistronic miRNA clusters preferentially harboring deregulated miRNAs in triple-negative breast cancer.25888956
Triple-Negative Breast Cancer FindingEpigenetic AlterationsTwo of these miRNA clusters (miR-143-145 at 5q32 and miR-497-195 at 17p13.1) were markedly down-regulated in triple-negative breast cancer, while the other five miRNA clusters (miR-17-92 at 13q31.3, miR-183-182 at 7q32.2, miR-200-429 at 1p36.33, miR-301b-130b at 22q11.21, and miR-532-502 at Xp11.23) were up-regulated in triple-negative breast cancer.25888956
Triple-Negative Breast Cancer FindingEpigenetic AlterationsDeregulated microRNAs in triple-negative breast cancer revealed by deep sequencing.25888956
Breast Carcinoma, Triple-Negative Breast Cancer FindingEpigenetic AlterationsHowever, the regulatory characteristics of miRNAs in triple-negative breast cancer, a phenotype of breast cancer that does not express the genes for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are still poorly understood.25888956
Triple-Negative Breast Cancer FindingEpigenetic AlterationsDeregulated miRNAs in triple-negative breast cancer were identified from the sequencing data using the Students t-test.25888956
Primary malignant neoplasmEpigenetic AlterationsValidated molecular targets of the deregulated miRNAs were retrieved from curated databases and their associations with cancer progression were discussed.25888956
Plaque (lesion)Epigenetic AlterationsThe data showed target genes regulated by these statin induced miRNAs majorly expressed in i) plaque macrophage and platelet, where they were involved in hemostasis process; ii) in monocyte to regulate NGF apoptosis; iii) and in endothelial cell function in Rho GTPase pathway.25889164
Hodgkin Disease, Huntington Disease, Neurodegenerative DisordersEpigenetic AlterationsIn Huntingtons disease (HD), a neurodegenerative disease caused by a trinucleotide repeat expansion, miRNA dyregulation has been reported, which may impact gene expression and modify the progression and severity of HD.25889241
Hodgkin DiseaseEpigenetic AlterationsThe miRNAs identified in our studies of postmortem brain tissue may be detectable in peripheral fluids and thus warrant consideration as accessible biomarkers for disease stage, rate of progression, and other important clinical characteristics of HD.25889241
Liver carcinomaEpigenetic AlterationsTP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma.25889455
Malignant Neoplasms, Hollings Cancer CenterEpigenetic AlterationsAs epigenetic changes are considered possible surrogates to mutations in human cancers, we decided, thus, to characterize DNA methylation in HCC from North-African patients.25889455
CarcinomaEpigenetic AlterationsMore importantly, DNA methylation was significantly higher in Arg/Arg when compared to Pro/Pro genotype carriers at codon 72 rs1042522 of TP53 (65% vs 20% methylated loci, p = 0.0006), a polymorphism already known to affect somatic mutation rate in human carcinomas.25889455
Hollings Cancer CenterEpigenetic AlterationsOur data suggest that Arg72Pro polymorphism in a WT p53 context may act as a primary driver of epigenetic changes in HCC.25889455
Carcinogenesis, Hollings Cancer CenterEpigenetic AlterationsThis model of liver tumorigenesis that associates low penetrance genetic predisposition to epigenetic changes emerges from a region of low HCC incidence and it may, therefore, apply essentially to population living in similar areas.25889455
Carcinoma of lung, MetastasisEpigenetic AlterationsIncreased expression of the long non-coding RNA ANRIL promotes lung cancer cell metastasis and correlates with poor prognosis.25889788
Primary malignant neoplasmEpigenetic AlterationsEmerging evidences indicate that dysregulated long non-coding RNAs (lncRNAs) are implicated in cancer tumorigenesis and progression.25889788
Malignant Neoplasms, Neoplasms, Refractory Cytopenia of ChildhoodEpigenetic AlterationsIncreasing evidence has shown that microRNAs function as oncogenes or tumor suppressors in human malignancies, but the roles of miR-203 in human RCC is still unclear.25890121
Epilepsy, Inflammation, SeizuresEpigenetic AlterationsRecently, a growing body of evidence has suggested that microRNA-146a (miR-146a) is upregulated in the brains of epilepsy patients and of mouse models; furthermore, miR-146a may be involved in the development and progression of seizures through the regulation of inflammation and immune responses.25891929
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsAccumulation of epigenetic alterations causes inactivation of tumor suppressors and contributes to the initiation and progression of hepatocellular carcinoma (HCC).25892360
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs are frequently altered in numerous cancers and are critical regulators of various diseases.25894339
Carcinoma of lung, Retinoblastoma, Metastasis, melanomaEpigenetic AlterationsRecent evidence shows that BRAF-activated non-coding RNA (BANCR) acts as a critical role in the proliferation and metastasis in malignant melanoma and lung cancer; however, little is known about the significance of lncRNA BANCR in retinoblastoma.25894373
Chronic liver disease, Liver carcinomaEpigenetic AlterationsPlasma microRNA might as a potential biomarker for hepatocellular carcinoma and chronic liver disease screening.25894380
Colorectal Cancer PathwayEpigenetic AlterationsLong non-coding RNA LINC01296 is a potential prognostic biomarker in patients with colorectal cancer.25894381
Malignant tumor of colonEpigenetic AlterationsIncreased microRNA-34b and -34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancer.25894979
NeoplasmsEpigenetic AlterationsThe microRNA-34 family (miR-34a, -34b and -34c) have been reported to be tumor suppressor microRNAs (miRNAs) that are regulated by the TP53 and DNA hypermethylation.25894979
Colonic Neoplasms, NeoplasmsEpigenetic AlterationsAll miR-34 family members were significantly increased in colon tumors, counter to the proposed tumor suppressor role for these miRNAs.25894979
ovarian neoplasmEpigenetic AlterationsA novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ.25895125
Primary malignant neoplasmEpigenetic AlterationsThe involvement of microRNA in cancer progression has recently been reported, though whether they have a role in activating YAP and TAZ in human cancer cells remains unclear.25895125
Clinical CoordinatorEpigenetic AlterationsMiRNA-145 and miRNA-378* are potential biomarkers for early detection of CRC, which may help in diagnosing CRC in early period.25896668
Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAlthough microRNAs offer great potential as cancer biomarkers, effective clinical dignostics and tumor maker have not been verified to diagnose with colorectal cancer (CRC).25896668
Clinical CoordinatorEpigenetic AlterationsUsing enter and stepwise variable selection methods separately, conditional logistic regression was conducted to identify miRNAs associated with CRC.25896668
Clinical CoordinatorEpigenetic AlterationsIn this study, we confirmed 11 overexpressed miRNAs with no less than twofold difference, and 85 downexpressed miRNAs with up to 0.5-fold difference in CRC from 96 aberrantly expressed miRNAs being identified by real-time PCR.25896668
Neoplasm MetastasisEpigenetic AlterationsHOX transcript antisense RNA (HOTAIR), a long intergenic non-coding RNA (lncRNA), functions as a molecular scaffold to link and target the histone modification complexes PRC2 and LSD1, then reprograms chromatin states by coupling histone H3K27 methylation and H3K4 demethylation for epigenetic gene silencing to promote cancer metastasis.25901533
InflammationEpigenetic AlterationsThus, these results provide an additional line of evidence that IWT is advantageous in promoting health from an epigenetic perspective by ameliorating susceptibility to inflammation.25901949
Carcinogenesis, NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumor suppressor genes is involved in early transforming events and has a high impact on colorectal carcinogenesis.25902909
Malignant tumor of colon, Intestinal DiseasesEpigenetic AlterationsLikewise, colon cancers that derive from chronically inflamed bowel diseases frequently exhibit epigenetic changes.25902909
Colorectal Cancer PathwayEpigenetic AlterationsBut there is little data about epigenetic aberrations causing colorectal cancer in chronically inflamed tissue.25902909
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMiR-133a serves as a tumor-suppressive miRNA in human NSCLC, and its downregulation suggests deterioration in NSCLC patients.25903369
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsEpigenetic regulation of the novel tumor suppressor cysteine dioxygenase 1 in esophageal squamous cell carcinoma.25903467
Head and Neck NeoplasmsEpigenetic AlterationsTo expand our currently sparse knowledge of the noncoding alterations involved in the disease and identify potential biomarkers and therapeutic targets, we globally profiled the dysregulation of small nucleolar and long noncoding RNAs in head and neck tumors.25904139
Malignant Head and Neck NeoplasmEpigenetic AlterationsWe confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration.25904139
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsAs a whole, noncoding RNAs are pervasively dysregulated in head and squamous cell carcinoma.25904139
Borderline Personality Disorder, Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe expression of all three miRNAs were significantly lower in the serum of NSCLC than that of BPD and healthy controls (all p<0.01), and their expression levels were strongly correlated with each other (r=0.781, 0.720, and 0.645, respectively).25904302
Triple-Negative Breast Cancer FindingEpigenetic AlterationsCirculating cell-free miRNAs as biomarker for triple-negative breast cancer.25906045
Pancreatic carcinomaEpigenetic AlterationsWe found a prediction model for postoperative prognosis of pancreatic cancer using 7 microRNA expression patterns from archived formalin-fixed paraffin-embedded surgical specimens.25906450
Pancreatic carcinomaEpigenetic AlterationsPostoperative prognosis prediction of pancreatic cancer with seven microRNAs.25906450
Malignant NeoplasmsEpigenetic AlterationsMiRNAs are a class of short noncoding RNAs that regulate mRNAs at posttranscriptional level and are deregulated in various human malignancies.25907662
Breast CarcinomaEpigenetic AlterationsIn particular, microRNA (miRNA) has attracted the interest of both basic and clinical investigators as one of the promising molecular markers of breast cancer patients.25907662
Breast CarcinomaEpigenetic AlterationsCorrelation of miRNA expression profiling in surgical pathology materials, with Ki-67, HER2, ER and PR in breast cancer patients.25907662
NeoplasmsEpigenetic AlterationsFor instance, an abundant expression of multiple let-7 miRNA family, also known as tumor suppressor, was detected in low Ki-67 and HER2 groups.25907662
Malignant Neoplasms, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsAltered expression of microRNAs has been reported in wide range of malignancies, including pancreatic ductal adenocarcinoma.25908274
Metastasis, NeoplasmsEpigenetic AlterationsOur findings suggest that DNA methylation is a useful marker for tumor progression monitoring and that promoter methylation in certain genes is associated with more advanced tumor stage, poor differentiation, and metastasis.25908636
Clinical CoordinatorEpigenetic AlterationsCRC development is the result of genetic and epigenetic alterations accumulation in the epithelial cells of colon mucosa.25908636
Liver carcinomaEpigenetic AlterationsEpigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU.25909168
B-Cell LymphomasEpigenetic AlterationsMicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma.25909227
Diffuse Large B-Cell Lymphoma, NeoplasmsEpigenetic AlterationsThe results of this study show that, in contrast to solid tumors, the frequency of GADD45g methylation is higher and this epigenetic alteration of GADD45g may be associated with progression in DLBCL.25912017
Metastasis, Liver carcinomaEpigenetic AlterationsMicroRNA-129-5p inhibits hepatocellular carcinoma cell metastasis and invasion via targeting ETS1.25912876
NeoplasmsEpigenetic AlterationsMoreover, the expression of tumor suppressor microRNA-145 (miR-145) was negatively correlated with RAD18 expression in CRC tissues of 140 patients.25913620
Squamous cell carcinoma of esophagusEpigenetic AlterationsExpression of circulating microRNA-20a and let-7a in esophageal squamous cell carcinoma.25914476
Prostatic HyperplasiaEpigenetic AlterationsOur findings suggest an individualized epigenetic signature for symptomatic benign prostatic hyperplasia, which may be important to choose appropriate personalized treatment options.25916673
Aortic Aneurysm, AbdominalEpigenetic AlterationsPlasma microRNAs serve as potential biomarkers for abdominal aortic aneurysm.25916817
Thyroid Gland Follicular AdenomaEpigenetic AlterationsmicroRNA expression in autonomous thyroid adenomas: Correlation with mRNA regulation.25916957
NeoplasmsEpigenetic AlterationsThe global miRNA profiles were not greatly modified, confirming the definition of these tumors as minimal deviation tumors.25916957
NeoplasmsEpigenetic AlterationsThese results support a role for miRNA in the regulation of extracellular matrix proteins and tissue remodeling occurring during tumor development, and in the important negative feedback of the cAMP pathway, which limits the consequences of its constitutive activation in these tumors.25916957
NeoplasmsEpigenetic AlterationsTwelve miRNAs were downregulated and one was upregulated in the tumors.25916957
Carcinoma of lungEpigenetic AlterationsHowever the effect of miRNA in lung cancer chemoresistance is poorly understood.25917317
Carcinoma of lung, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTaken together our findings imply that the miRNAs miR-205 and miR-218 play a key role in the development of lung cancer acquired chemoresistance and the tumor suppressor role of miR-218 in inhibiting lung cancer cell tumorigenesis and overcoming platinum chemoresistance is significant for future cancer therapeutic approaches.25917317
Malignant tumor of colonEpigenetic AlterationsWe hypothesize that CLU gene is regulated by DNA methylation and histone modifications and clusterin plays an important role in colon cancer.25917404
Malignant tumor of colonEpigenetic AlterationsClusterin gene is predominantly regulated by histone modifications in human colon cancer and ectopic expression of the nuclear isoform induces cell death.25917404
Cancer-Related DeathEpigenetic AlterationsEctopic expression of nCLU either by epigenetic modulators or by nCLU transfection is responsible for colon cancer cell death.25917404
Malignant neoplasm of urinary bladder, Forecast of outcomeEpigenetic AlterationsCorrelation of Increased Expression of MicroRNA-155 in Bladder Cancer and Prognosis.25918190
Hepatocarcinogenesis, Hepatitis, ChronicEpigenetic AlterationsChronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis.25918251
Prostate Cancer PathwayEpigenetic AlterationsThe molecular mechanisms involved in androgen receptor (AR) signaling pathways are not completely understood, and deregulation of microRNAs (miRNAs) expression may play a role in prostate cancer (PC) development and progression.25920548
Stomach Carcinoma, Stage I Esophageal Squamous Cell Carcinoma AJCC v7, Squamous cell carcinoma of esophagusEpigenetic AlterationsPopulations in north central China are at high risk for oesophageal squamous cell carcinoma (ESCC) and gastric cancer (GC), and genetic variation in epigenetic machinery genes and pathways may contribute to this risk.25921222
Malignant Neoplasms, Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsMicroRNA expression profiling revealed thatsome oncogenic microRNAsincluding miR-155 and miR-126 were up-regulated, whilst anti-oncogenic microRNAsincluding miR-148a and miR-193a were down-regulated in MAPKBP1high patients with CN-AML, which may underlie the pathological processes in this malignancy.25924238
Colorectal Cancer PathwayEpigenetic AlterationsCirculating miRNAs miR-34a and miR-150 associated with colorectal cancer progression.25924769
polyps, Primary malignant neoplasm, AdenomaEpigenetic AlterationsThe expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples.25924769
Colonic Diseases, Primary malignant neoplasmEpigenetic AlterationsWe identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups.25924769
Malignant NeoplasmsEpigenetic AlterationsChanges in the expression of microRNAs (miRNAs) have been found in many cancers.25925090
Osteosarcoma, Malignant Bone NeoplasmEpigenetic AlterationsMicroRNA-145 expression in the plasma of patients with benign and malignant bone tumors and its effects on osteosarcoma cell proliferation and migration.25926306
Malignant Bone NeoplasmEpigenetic AlterationsThe difference in microRNA-145 expression level in the tissue between patients with benign and malignant bone tumors were compared and analyzed.25926306
OsteosarcomaEpigenetic AlterationsHuman osteosarcoma cell line OS-732 was used for high and low expressions of microRNA-145.25926306
Bone neoplasms, Malignant Bone NeoplasmEpigenetic AlterationsMicroRNA-145 expression level in the plasma of patients with malignant bone tumors was significantly lower than that of patients with benign bone tumors; microRNA-145 expression level in the plasma of patients with benign bone tumors was significantly lower than that of healthy subjects; the differences were statistically significant (P<0.05).25926306
Bone neoplasms, Malignant Bone NeoplasmEpigenetic AlterationsMicroRNA-145 expression level in the tissue of patients with malignant bone tumors was significantly lower than that of patients with benign bone tumors; the difference was statistically significant (P<0.05).25926306
OsteosarcomaEpigenetic AlterationsCell proliferation level of human osteosarcoma cell line OS-732 interfered with microRNA-145 was significantly increased, and its cell invasion capacity was also significantly increased; the differences were statistically significant (P < 0.05).25926306
Osteosarcoma, Malignant Bone Neoplasm, NeoplasmsEpigenetic AlterationsLow expression of microRNA-145 in patients with malignant bone tumors may be involved in cell proliferation and invasion of malignant bone tumors like osteosarcoma as a tumor suppressor.25926306
melanoma, Non-Small Cell Lung CarcinomaEpigenetic AlterationsBRAF activated non-coding RNA (BANCR), a long non-coding RNA (lncRNA), is crucial for cell migration in melanoma cells and non-small cell lung cancer (NSCLC) cells.25928067
Colorectal Cancer PathwayEpigenetic AlterationsDownregulated Long Noncoding RNA BANCR Promotes the Proliferation of Colorectal Cancer Cells via Downregualtion of p21 Expression.25928067
Esophageal carcinomaEpigenetic AlterationsMicroRNA expression levels were further analyzed in regards to clinico-pathological features of esophageal cancer patients.25928282
Malignant Neoplasms, Esophageal carcinomaEpigenetic AlterationsAltered expression of microRNAs has been reported in wide range of malignancies, including esophageal cancer.25928282
Esophageal carcinomaEpigenetic AlterationsOur data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.25928282
ovarian neoplasmEpigenetic AlterationsPromoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer.25931269
ovarian neoplasmEpigenetic AlterationsOur data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis.25931269
Leukemia, Myelocytic, AcuteEpigenetic AlterationsTo identify potential molecular prognostic markers in core binding factor (CBF) AML, we analyzed incidences and prognostic impacts of mutations in c-KIT, WT1, CEBPA, CBL, and a number of epigenetic genes in CBF AML.25932436
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe incidences of mutations in epigenetic genes are very low in CBF AML; however, c-KIT and WT1 mutations occur more frequently than others.25932436
Meningioma, NeoplasmsEpigenetic AlterationsThese findings provide insights into RIZ1 tumor suppression mechanisms and suggest that TAT-RIZ1-PR protein is a potential new epigenetic therapeutic agent for advanced meningiomas.25934289
Breast CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) are short non-coding RNA molecules that play a critical role in mRNA cleavage and translational repression, and are known to be altered in many diseases including breast cancer.25934412
Breast Carcinoma, MIR10A geneEpigenetic AlterationsMicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid.25934412
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-10a (miR-10a) has been shown to be deregulated in various cancer types.25934412
Cerebral IschemiaEpigenetic AlterationsMicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation.25934573
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsTogether, these results suggested for the first time, to the best of our knowledge, ADAMTS1 as a novel antitumor protease, and this function was lost following epigenetic silencing in the gastric cancer cells and gastric tumor tissues.25936341
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-383 expression regulates proliferation, migration, invasion, and apoptosis in human glioma cells.25936342
Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression.25936394
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsTranscriptional changes were mapped on the myocyte GEM, revealing extensive transcriptional regulation in T2D, particularly around pyruvate oxidation, branched-chain amino acid catabolism, and tetrahydrofolate metabolism, connected through the downregulated dihydrolipoamide dehydrogenase.25937284
Prostate Cancer Pathway, HemorrhageEpigenetic AlterationsRelation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy for prostate cancer.25937401
Degenerative polyarthritisEpigenetic AlterationsGain of 5hmC in the gene body is found to be characteristic of activated genes in OA chondrocytes, highlighting the influence of 5hmC as an epigenetic mark in OA.25940674
NeoplasmsEpigenetic AlterationsThe UHRF1 protein is pivotal for DNA methylation and heterochromatin formation, leading to decreased expressions of tumor suppressor genes and contributing to tumorigenesis.25940709
Colorectal Cancer PathwayEpigenetic AlterationsRegulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis.25940709
Clinical CoordinatorEpigenetic AlterationsHere we showed that, compared with corresponding normal tissues, UHRF1 was upregulated and microRNA-9 (miR-9) was downregulated in CRC tissues.25940709
Secondary malignant neoplasm of liverEpigenetic AlterationsIn conclusion, SI-NET tissue microRNAs are always detectable in untreated and SSA-treated patient serum samples, SSAs play an unknown role in eliciting SSA-treated patients microRNA levels higher than in untreated patients, and this study enlightens that miR-200a might be involved in the liver metastasis during SI-NET progression.25942502
Small Intestinal Neuroendocrine TumorEpigenetic AlterationsSomatostatin Analogs Treated Small Intestinal Neuroendocrine Tumor Patients Circulating MicroRNAs.25942502
Colorectal Cancer PathwayEpigenetic AlterationsApplication of artificial neural networks to link genetic and environmental factors to DNA methylation in colorectal cancer.25942531
Clinical CoordinatorEpigenetic AlterationsANNs revealed the complexity of the interconnections among factors linked to DNA methylation in CRC.25942531
Hollings Cancer CenterEpigenetic AlterationsMutations associated with HCC risk were mainly located in HBx transactivation domain, viral promoter, protein/miRNA binding sites, and the area for immune epitopes.25942596
Barrett Esophagus, Primary malignant neoplasmEpigenetic AlterationsFour hundred eight miRNA ratios were differentially expressed in individuals with cancer compared to controls and Barretts esophagus (Mann-Whitney U test, P < 0.05).25943911
Adenocarcinoma Of EsophagusEpigenetic AlterationsCirculating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma.25943911
Primary Neoplasm, Colorectal Cancer PathwayEpigenetic AlterationsComparison of genetic and epigenetic alterations of primary tumors and matched plasma samples in patients with colorectal cancer.25946211
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsWe analyzed the status of the two best characterized colorectal cancer (CRC) genetic and epigenetic alterations in a cohort of CRC patients, and then compared the degree to which the two patterns move from tissue to plasma in order to improve our understanding of biology modulating the concordance between tissues and plasma methylation and mutation profiles.25946211
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsCirculating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma.25950115
Breast Cancer CellEpigenetic AlterationsCirculating microRNAs (miRNAs) are emerging as promising non-invasive biomarkers for human cancer.25950115
Glioblastoma Multiforme PathwayEpigenetic AlterationsGenetic and epigenetic status, including mutations of isocitrate dehydrogenase (IDH) and TP53 and methylation of O(6) -methylguanine-DNA methyltransferase (MGMT), are associated with the development of various types of glioma and are useful for prognostication.25950388
Adenocarcinoma Of EsophagusEpigenetic AlterationsmicroRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy.25950983
NeoplasmsEpigenetic AlterationsAlthough no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of microRNA-21 might represent an escape mechanism of tumor cells.25950983
Uveal melanoma, Vitreous humorEpigenetic AlterationsmiRNA profiling in vitreous humor, vitreal exosomes and serum from uveal melanoma patients: Pathological and diagnostic implications.25951497
Malignant Neoplasms, Vitreous humorEpigenetic AlterationsBased on the assumption that the profile of circulating miRNAs is often altered in human cancers, we verified whether UM patients showed different vitreous humor (VH) or serum miRNA profiles with respect to healthy controls.25951497
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA let-7, a putative tumor suppressor, is dysregulated in many cancers.25951903
Malignant NeoplasmsEpigenetic AlterationsEarlier studies demonstrated that microRNAs (miRNAs) might be involved in the chemosensitivity of cancers.25951903
Multiple Chronic Conditions, Obesity, Diabetes Mellitus, Primary malignant neoplasmEpigenetic AlterationsCirculating microRNA 130b has been closely associated with multiple diseases in humans such as cancer, obesity and diabetes mellitus.25952368
GliomaEpigenetic AlterationsHowever, both the expression pattern of miRNAs in gliomas of different grades and various miRNAs involved in malignant progression of gliomas are poorly understood.25954994
GliomaEpigenetic AlterationsIn total, we found 13 differentially expressed miRNAs between gliomas and their matched surrounding tissues.25954994
GliomaEpigenetic AlterationsOur microarray result revealed 8, 9 and 15 aberrantly expressed miRNAs in gliomas of World Health Organization (WHO) grade II-IV, respectively.25954994
Malignant neoplasm of endometrium, Primary malignant neoplasmEpigenetic AlterationsThe tumor-suppressive microRNA-1/133a cluster targets PDE7A and inhibits cancer cell migration and invasion in endometrial cancer.25955017
Malignant NeoplasmsEpigenetic AlterationsOur recent studies of microRNA (miRNA) expression signatures revealed that the microRNA-1/133a (miR-1/133a) cluster is frequently downregulated in various types of human cancers.25955017
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMoreover, restoration of mature miR-1 or miR-133a miRNAs significantly inhibited cancer cell migration and invasion, suggesting that these clustered miRNAs act as tumor suppressors.25955017
MetastasisEpigenetic AlterationsElucidation of the molecular networks regulated by tumor-suppressive miRNAs will provide insights into the molecular mechanisms of EC oncogenesis and metastasis.25955017
Nasopharyngeal carcinomaEpigenetic AlterationsThe role of Epstein-Barr virus-encoded microRNA BART7 status of resection margins in the prediction of local recurrence after salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma.25955785
NeoplasmsEpigenetic AlterationsIn patients with clear histologic margins, those with margins that were positive for EBV microRNA BART7 has a significantly higher chance of developing local tumor recurrence (P = .016) than those with negative molecular margins.25955785
NeoplasmsEpigenetic AlterationsTissue EBV microRNA BART7 is useful for identifying a subgroup of patients with histologically clear margins who are at increased risk of subsequent local tumor recurrence.25955785
Squamous cell carcinoma, MetastasisEpigenetic AlterationsMicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B.25955794
SERPINB3 wt Allele, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsmiR-216a has been identified as being involved in tumorigenesis, however, the mechanisms of miR-216a in various types of cancer, either as a tumor suppressor or as an oncogenic miRNA, and the specific regulatory role of miR-216a in OSCC remain to be elucidated.25955794
Squamous cell carcinoma, SERPINB3 wt AlleleEpigenetic AlterationsThere is increasing evidence to suggest that microRNAs (miRNAs; miRs) are involved in the development of oral squamous cell carcinoma (OSCC).25955794
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsAccuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma.25956054
Stomach CarcinomaEpigenetic AlterationsOverexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance.25956062
DysplasiaEpigenetic AlterationsAmong SF3B1-mutated patients, coexisting mutations in DNA methylation genes were associated with multilineage dysplasia (P = .015) but had no effect on clinical outcome.25957392
Stomach CarcinomaEpigenetic AlterationsOur findings help to indicate the hypermethylation at EGFR promoter in gastric cancer and it could be a potential epigenetic biomarker for gastric cancer status and progression.25959250
Malignant NeoplasmsEpigenetic AlterationsLong non-coding RNAs (lncRNAs), which have evolved as important gene expression modulators, are involved in human malignancies.25959498
Antilymphocyte SerumEpigenetic AlterationsThe results suggest that more work is needed to elucidate possible environmental, epigenetic, oligogenic and somatic genetic factors that could underlie susceptibility to sporadic ALS.25960086
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsmicroRNAs (miRNAs) are known to be involved in the pathogenesis of hepatocellular carcinoma (HCC).25962360
Ovarian Serous AdenocarcinomaEpigenetic AlterationsUrinary microRNA-30a-5p is a potential biomarker for ovarian serous adenocarcinoma.25962395
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) can serve as biomarkers in human cancer.25962395
Malignant NeoplasmsEpigenetic AlterationsHowever, the DNA methylation state of the 45 S rDNA promoter, as well as its effect on rRNA gene expression in types of human cancers is controversial.25962577
Myasthenia GravisEpigenetic AlterationsDecreased microRNA miR-181c expression in peripheral blood mononuclear cells correlates with elevated serum levels of IL-7 and IL-17 in patients with myasthenia gravis.25962782
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsCirculating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC).25962820
MIR206 wt AlleleEpigenetic AlterationsThe miRNAs exhibiting differential expression were hsa-miR-122-5p, has-miR-199a-5p, hsa-miR-486-5p, has-miR-193b-5p, hsa-miR-206, has-miR-141-3p, has-miR-192-5p and has-miR-26a-5p.25962820
daunorubicinolEpigenetic AlterationsThese results suggest that DNA methylation impacts AKR7A2 expression and the synthesis of cardiotoxic daunorubicinol.25962911
ovarian neoplasmEpigenetic AlterationsDifferential MicroRNA Expression Profiles in Primary and Recurrent Epithelial Ovarian Cancer.25964536
ovarian neoplasmEpigenetic AlterationsAlthough it has been shown that microRNAs influence messenger RNA post-transcriptional control and can attribute to human tumorigenesis, little is known regarading the differences in microRNA expression between primary and recurrent epithelial ovarian cancer (EOC).25964536
NeoplasmsEpigenetic AlterationsBetween September 2013 and May 2014, the expression of microRNAs in tumor tissues from 5 primary and 5 recurrent EOC cases were analyzed.25964536
Mutation-Negative Lynch SyndromeEpigenetic AlterationsAmong mutation-negative specimens, miRNA testing correctly identified 64% of malignant cases and 98% of benign cases.25965083
NeoplasmsEpigenetic AlterationsInterestingly, microRNA-424 was downregulated in clinically normal tongue tissue next to tumour compared with completely healthy tongue, indicating that microRNA-424 could be a marker of field cancerisation in this tumour type.25965165
Squamous cell carcinomaEpigenetic AlterationsOur patient data show that microRNA-424 alterations are a marker of field cancerisation specific for tongue tumourigenesis, which also could have a role in development of tongue squamous cell carcinoma.25965165
Squamous cell carcinomaEpigenetic AlterationsDownregulation of miRNA-424: a sign of field cancerisation in clinically normal tongue adjacent to squamous cell carcinoma.25965165
Squamous cell carcinoma of the head and neckEpigenetic AlterationsMicroRNAs have been suggested as potential prognostic and diagnostic candidates in squamous cell carcinoma of head and neck in general.25965165
Carcinoma of lungEpigenetic AlterationsOur 24-microRNA predictor improves lung cancer prediction beyond that of known risk factors.25965386
Primary malignant neoplasmEpigenetic AlterationsCirculating MicroRNAs as Non-Invasive Biomarkers for Early Detection of Non-Small-Cell Lung Cancer.25965386
Carcinoma of lungEpigenetic AlterationsOur objective was to identify a panel of circulating microRNAs in plasma that will contribute to early detection of lung cancer.25965386
Malignant Neoplasms, Pancreatic carcinomaEpigenetic AlterationsRecent researches demonstrate that microRNAs (miRNAs) are deregulated in numerous cancers and involved in tumorigenesis, whereas their influences on pancreatic cancer (PC) still need further elucidation.25965392
Carcinoma of lungEpigenetic AlterationsAs one of the most important and widely studied families of microRNA, let-7 appears to play an important role in initiation and progression of lung cancer.25966223
Liver carcinomaEpigenetic AlterationsLong non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of KLF2.25966845
Malignant Neoplasms, Hollings Cancer CenterEpigenetic AlterationsGrowing evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in many cancers, including HCC.25966845
HIV InfectionsEpigenetic AlterationsOverall, our results demonstrate that the epigenetic clock is a useful biomarker for detecting accelerated aging effects due to HIV infection.25969563
Conventional (Clear Cell) Renal Cell Carcinoma, NeoplasmsEpigenetic AlterationsFrequent epigenetic suppression of tumor suppressor gene glutathione peroxidase 3 by promoter hypermethylation and its clinical implication in clear cell renal cell carcinoma.25970749
Conventional (Clear Cell) Renal Cell Carcinoma, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe goal of this study is to identify novel tumor suppressor genes silenced by promoter methylation in clear cell renal cell carcinoma (ccRCC) and discover new epigenetic biomarkers for early cancer detection.25970749
MetastasisEpigenetic AlterationsGlobal miRNA profiling on the Training Set and functional analysis in vitro suggested that miRNA-138 and its downstream RHO-ROCK cell adhesion pathway was a convergent target of miRNAs associated with the development of metastasis.25970788
SarcomaEpigenetic AlterationsPrognostic microRNAs modulate the RHO adhesion pathway: A potential therapeutic target in undifferentiated pleomorphic sarcomas.25970788
Chronic Lymphocytic LeukemiaEpigenetic Alterationsp53-dependent non-coding RNA networks in chronic lymphocytic leukemia.25971364
Chronic Lymphocytic LeukemiaEpigenetic AlterationsWhereas p53 targets are used to identify patient subgroups with impaired p53 function, a comprehensive assessment of non-coding RNA targets of p53 in CLL is missing.25971364
Chronic Lymphocytic LeukemiaEpigenetic AlterationsWe describe the landscape of p53-dependent microRNA/non-coding RNA induced in response to DNA damage in CLL.25971364
Chronic Lymphocytic LeukemiaEpigenetic AlterationsIn addition to miRNAs, the long non-coding RNAs (lncRNAs) nuclear enriched abundant transcript 1 (NEAT1) and long intergenic non-coding RNA p21 (lincRNA-p21) are induced in response to DNA damage in the presence of functional p53 but not in CLL with p53 mutation.25971364
Multiple MyelomaEpigenetic AlterationsmiRNA-202 in bone marrow stromal cells affects the growth and adhesion of multiple myeloma cells by regulating B cell-activating factor.25971527
Admitting diagnosisEpigenetic AlterationsEpigenetic dysregulation, including aberrations in histone acetylation, is also associated with AD.25972179
Acute Lung InjuryEpigenetic AlterationsChanged profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1.25972997
Stomach CarcinomaEpigenetic AlterationsMicroRNA-141 inhibits migration of gastric cancer by targeting zinc finger E-box-binding homeobox 2.25975736
Stomach CarcinomaEpigenetic AlterationsHuman microRNA (miR)-141 is a member of the miR-200 family, which has been reported to be downregulated in gastric cancer, and involved in the proliferation of gastric cancer cells.25975736
diabetic, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsmiRNA 9 levels were expected to be over expressed in diabetic patients, while miRNA 370 levels were expected to be over expressed in those suffering from CAD and their association with CAD complication of T2D.25978320
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsMicroRNAs 9 and 370 Association with Biochemical Markers in T2D and CAD Complication of T2D.25978320
NeoplasmsEpigenetic AlterationsQuantifying levels of DNA methylation in tumors is a useful approach for the identification of potential tumor suppressors and to find biomarkers that can be used as prognostic or therapeutic indicators.25979762
Malignant Neoplasms, Stomach CarcinomaEpigenetic AlterationsIn the current study, we compared three methods commonly used for quantifying DNA methylation-bisulfite pyrosequencing, quantitative methylation-specific PCR (Q-MSP), and MethyLight-by focusing on the CpG island of the gene encoding the microRNA-34b and microRNA-34c (miR-34b/c); aberrant regulation of this miR is associated with various human malignancies, including gastric cancer.25979762
Chromophobe Renal Cell CarcinomaEpigenetic AlterationsMicroRNA expression profiles predict clinical phenotypes and prognosis in chromophobe renal cell carcinoma.25981392
NeoplasmsEpigenetic AlterationsOverall, a total of 105 miRNAs were found to be differentially expressed between tumor and the adjacent normal tissues from 22 chRCC patients.25981392
Oropharyngeal Carcinoma, NeoplasmsEpigenetic AlterationsA functional variant at miRNA-122 binding site in IL-1a 3 UTR predicts risk and HPV-positive tumours of oropharyngeal cancer.25981582
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROME, Primary malignant neoplasmEpigenetic AlterationsOxidative stress and abnormal DNA methylation have been implicated in some types of cancer, namely in myelodysplastic syndromes (MDS).25982567
Liver carcinomaEpigenetic AlterationsA systematic investigation based on microRNA-mediated gene regulatory network reveals that dysregulation of microRNA-19a/Cyclin D1 axis confers an oncogenic potential and a worse prognosis in human hepatocellular carcinoma.25985117
Hollings Cancer CenterEpigenetic AlterationsLuciferase reporter assay confirmed that miRNA-19a, which was one of HCC downregulated miRNAs, directly targeted Cyclin D1 in HCC cells.25985117
DiseaseEpigenetic AlterationsMicroRNAs (miRNAs) contribute to a wide variety of human diseases by regulating gene expression, leading to imbalances in gene regulatory networks.25985117
Hollings Cancer CenterEpigenetic AlterationsAs a result, a total of 117 HCC differentially expressed miRNAs were identified, and 728 high confident target genes of these miRNAs were collected.25985117
Hollings Cancer CenterEpigenetic AlterationsIn conclusion, this systematic investigation provides a framework to identify featured miRNAs and their target genes which are potent effectors in the occurrence and development of HCC.25985117
Heart failure, Systolic dysfunctionEpigenetic AlterationsThe relationship between circulating microRNAs and left ventricular mass in symptomatic heart failure patients with systolic dysfunction.25985726
Heart failureEpigenetic AlterationsIn recent years, many microRNAs (miRNAs) were shown to be dysregulated in specific tissues playing critical roles in the pathogenesis and progression of heart failure (HF).25985726
Stomach CarcinomaEpigenetic AlterationsA Long Non-coding RNA Activated by Transforming Growth Factor-b is an Independent Prognostic Marker of Gastric Cancer.25986864
Leukemia, Myelocytic, AcuteEpigenetic AlterationsIDH1/2 mutations which result in alternation in DNA methylation pattern are one of the most common methylation associated mutations in Acute myeloid leukaemia.25987093
Colorectal CarcinomaEpigenetic AlterationsFecal microRNA profile in patients with colorectal carcinoma before and after curative surgery.25989926
Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsCancer biopsy, colonic mucosa from the resected specimens, and fecal samples from patients and controls were screened for 13 miRNAs involved in CRC onset and progressions by reverse transcription quantitative PCR (RT-qPCR).25989926
Primary malignant neoplasmEpigenetic AlterationsCancer tissue contained significantly higher expression of all miRNAs, compared to normal mucosa (p < 0.05).25989926
Clinical CoordinatorEpigenetic AlterationsExpression of preoperative levels of five fecal miRNAs, (miR-19-b-3p, miR-20a-5p, miR-21-3p, miR92a-3p, miR141) was significantly higher in CRC patients compared to controls and significantly decreased after curative surgery.25989926
Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsA set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention.25989926
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA expression profiles in muscle-invasive bladder cancer: identification of a four-microRNA signature associated with patient survival.25990459
Iron binding capacity measurement, Aggressive behaviorEpigenetic AlterationsIn summary, this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC.25990459
MIR20A geneEpigenetic AlterationsOnly 43% (miR-17), 43% (miR-18b), 53% (miR-20a), and 60% (miR-193-3p) showed a continuous in- or decrease of miRNA expression.25990502
MIR20A gene, Primary malignant neoplasmEpigenetic AlterationsFive miRNAs associated with rectal cancer (miR-17, miR-18b, miR-20a, miR-31, and miR-193-3p) were analyzed in the plasma of rectal cancer patients (n = 42) using qPCR.25990502
Classical phenylketonuriaEpigenetic AlterationsAltered DNA methylation in PAH deficient phenylketonuria.25990862
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsInitial results point to a possible involvement of miRNA in Alzheimers disease (AD).25992776
Admitting diagnosisEpigenetic AlterationsReferring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs.25992776
Aortic Aneurysm, AbdominalEpigenetic AlterationsThe potential role of DNA methylation in abdominal aortic aneurysms.25993294
Aortic Aneurysm, AbdominalEpigenetic AlterationsAdventitial Tertiary Lymphoid Organs as Potential Source of MicroRNA Biomarkers for Abdominal Aortic Aneurysm.25993295
atheroscleroticEpigenetic AlterationsAlternation of histone and DNA methylation in human atherosclerotic carotid plaques.25993995
Atherosclerotic lesionEpigenetic AlterationsWe here analysed histone and DNA methylation and the expression of corresponding methyltransferases in early and advanced human atherosclerotic carotid lesions in comparison to healthy carotid arteries.25993995
ArteriosclerosisEpigenetic AlterationsThe extent of histone and DNA methylation and expression of some corresponding methyltransferases are significantly altered in atherosclerosis, suggesting a possible contribution of epigenetics in disease development.25993995
ArteriosclerosisEpigenetic AlterationsLittle is known about epigenetics and its possible role in atherosclerosis.25993995
Lupus ErythematosusEpigenetic AlterationsDespite growing evidence that large intergenic noncoding RNAs (lincRNAs) can regulate gene expression and widely take part in normal physiological and disease conditions, our knowledge of systemic lupus erythematosus (SLE)-related lincRNAs remains limited.25994030
Transitional cell carcinoma of ureterEpigenetic AlterationsThe long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells.25994132
Hematologic Neoplasms, Primary malignant neoplasm, Leukemia, Myelocytic, AcuteEpigenetic AlterationsAberrant DNA methylation is known to occur in cancer, including hematological malignancies such as acute myeloid leukemia (AML).25996682
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe results showed that decreased methylation at HOXB3 and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML, while increased DNA methylation at DCC distinctive to the high-risk AML was associated with increased gene expression.25996682
Stomach CarcinomaEpigenetic AlterationsMicroRNA-29a inhibits cell migration and invasion via targeting Roundabout homolog 1 in gastric cancer cells.25997819
Stomach CarcinomaEpigenetic AlterationsMicroRNA-377 predicts poor clinical outcome of gastric cancer and induces tumorigenesis by targeting multiple tumor-suppressor genes.25998046
Primary malignant neoplasmEpigenetic AlterationsSpecifically, such polymorphisms can modulatebinding affinity or create or destroy miRNA-binding sites; such variants have also been found to be associated with cancer risk.25998065
Breast Carcinoma, Breast Cancer CellEpigenetic AlterationsMicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, including breast cancer.25998153
diabeticEpigenetic AlterationsMicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function.25999017
Coronary Vessel Bifurcation LesionEpigenetic AlterationsWe employed miRNA microarray to screen serum miRNAs profiles of patients with coronary bifurcation lesion and coronary nonbifurcation lesions.25999658
Cardiovascular DiseasesEpigenetic AlterationsRecent evidence suggests that cell-derived circulating miRNAs may serve as the biomarkers of cardiovascular diseases.25999658
Coronary Vessel Bifurcation LesionEpigenetic AlterationsOur findings suggest that these miRNAs may have a role in the pathogenesis of coronary bifurcation lesion and may represent novel biomarkers for the diagnosis and prognosis of coronary bifurcation lesion.25999658
F9 geneEpigenetic AlterationsWhile it is not associated with a more aggressive phenotype of PTC, it correlates with the reduction of all the markers of differentiation and is associated with overexpression of some miRNAs supposed to play a role in thyroid tumorigenesis.26003825
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsMicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo.26004521
Squamous cell carcinoma of esophagusEpigenetic AlterationsAccumulating evidence has shown that microRNAs (miRNAs) are aberrantly expressed in human esophageal squamous cell carcinoma (ESCC) and are crucial in tumorigenesis, among which miR-338-3p has been examined to be downregulated in patients with ESCC.26004521
MetastasisEpigenetic AlterationsEmerging evidences indicate that dysregulated microRNAs are implicated in the process of metastasis.26007293
Papillary thyroid carcinomaEpigenetic AlterationsMultivariate analysis involving the expression level of miR-9 and miR-21 and various clinical parameters identified the expression of these microRNAs as independent prognostic factors for papillary thyroid cancer patients.26007293
Malignant neoplasm of breastEpigenetic AlterationsTissue specific expression of extracellular microRNA in human breast cancers and normal human breast tissue in vivo.26008976
Breast CarcinomaEpigenetic AlterationsAfter absolute quantifications extracellular miRNA-21 was found to be significantly increased in breast cancer.26008976
Carcinogenesis, PremenopauseEpigenetic AlterationsIn breast tissue of pre-menopausal women miRNA-21 exhibited a cyclic variation during the menstrual cycle and in postmenopausal women six weeks of tamoxifen treatment decreased miRNA-21 suggesting that this miRNA may be important for breast carcinogenesis.26008976
Primary malignant neoplasmEpigenetic AlterationsEffect of genetic ancestry on leukocyte global DNA methylation in cancer patients.26012346
NeoplasmsEpigenetic AlterationsAlterations in DNA methylation patterns have been associated with different types of tumor.26012346
Breast Carcinoma, melanomaEpigenetic AlterationsSince the Uruguayan population is admixed and both melanoma and breast cancer have very high incidences in Uruguay compared to other populations, we examined whether individual ancestry influences global leucocyte DNA methylation status.26012346
Primary malignant neoplasmEpigenetic AlterationsAdditionally, we found a negative correlation between African ancestry and global DNA methylation in cancer patients (p <0.005).26012346
Primary malignant neoplasmEpigenetic AlterationsThese results support the potential use of global DNA methylation as a biomarker for cancer risk.26012346
Breast Carcinoma, melanomaEpigenetic AlterationsIn order to detect markers of susceptibility for the development of cutaneous melanoma and breast cancer in the Uruguayan population, we integrated genetic and epigenetic information of patients and controls.26012346
B-Lymphocytes, Diabetes, AutoimmuneEpigenetic AlterationsThe small contribution of b-cells to total plasma miR-375 levels make this miRNA an unlikely biomarker for b-cell function but suggests a utility for the detection of acute b-cell death for autoimmune diabetes.26013143
Vasculitis, CTCAEEpigenetic AlterationsCirculating microRNA expression pattern separates patients with anti-neutrophil cytoplasmic antibody associated vasculitis from healthy controls.26016752
MIR20A geneEpigenetic AlterationsSeven individual miRNAs were differently expressed compared to controls in both cohorts; miR-29a, -34a, -142-3p and -383 were up-regulated and miR-20a, -92a and -221 were down-regulated.26016752
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-217 functions as a prognosis predictor and inhibits colorectal cancer cell proliferation and invasion via an AEG-1 dependent mechanism.26016795
CardiovascularEpigenetic AlterationsSmoking-Associated DNA Methylation Biomarkers and Their Predictive Value for All-Cause and Cardiovascular Mortality.26017925
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs play critical roles in the development and progression of human cancers.26018509
Liver carcinomaEpigenetic AlterationsDNA methylation markers and serum a-fetoprotein level are prognostic factors in hepatocellular carcinoma.26019036
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4.26019136
Gastrointestinal Stromal TumorsEpigenetic AlterationsExpression profile of microRNAs in gastrointestinal stromal tumors revealed by high throughput quantitative RT-PCR microarray.26019448
Gastrointestinal Stromal TumorsEpigenetic AlterationsWe performed a quantitative real-time quantitative reverse transcriptase polymerase chain reaction assay to analyze the expression of 1888 miRNAs in a sample set that included 54 GIST tissue samples.26019448
Gastrointestinal Stromal TumorsEpigenetic AlterationsWe found that dysregulation of several miRNAs may be related to the malignant potential of GISTs.26019448
Gastrointestinal Stromal SarcomaEpigenetic AlterationsSix of these miRNAs, hsa-let-7c, miR-218, miR-488#, miR-4683, miR-34c-5p and miR-4773, were selected as the final list of biomarkers to separate the malignant GISTs (M group) from the benign GISTs (B group).26019448
Gastrointestinal Stromal TumorsEpigenetic AlterationsThe identified miRNAs appear to be novel biomarkers to distinguish malignant from benign GISTs, which may be helpful to understand the mechanisms of GIST oncogenesis and progression, and to further elucidate the characteristics of GIST subtypes.26019448
Prostate Cancer PathwayEpigenetic AlterationsMiRNA Profiles in Lymphoblastoid Cell Lines of Finnish Prostate Cancer Families.26020509
Prostate Cancer PathwayEpigenetic AlterationsAnnotating the SNPs with deep clinical data together with miRNA expression profiles can improve the understanding of the underlying mechanisms of different phenotypes of prostate cancer.26020509
Pancreatic carcinomaEpigenetic AlterationsNew DNA Methylation Markers for Pancreatic Cancer: Discovery, Tissue Validation, and Pilot Testing in Pancreatic Juice.26023084
Pancreatic carcinomaEpigenetic AlterationsWe identified and validated novel DNA methylation markers strongly associated with pancreatic cancer.26023084
SF3B1 wt AlleleEpigenetic AlterationsFurthermore, at miRNA expression profile, MDS ECFCs hypo-expressed various miRNAs involved in Wnt pathway regulation.26025663
Primary malignant neoplasmEpigenetic AlterationsThere is increasing evidence that the expression of microRNA (miRNA) in cancer is associated with chemosensitivity but the mechanism of miRNA-induced chemoresistance has not been fully elucidated.26026166
Osteoporotic FracturesEpigenetic AlterationsOverall, these data suggest that levels of specific circulating miRNAs change in the context of recent osteoporotic fractures and that such perturbations of "normal" levels might affect bone metabolism or bone healing processes.26026730
NeoplasmsEpigenetic AlterationsNickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression.26026961
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsEpigenetic changes, including DNA methylation, are recognized as one of the potential mechanisms involved in the pathogenesis of hepatocellular carcinoma (HCC).26030814
Hepatocarcinogenesis, Hepatitis CEpigenetic AlterationsAberrant methylation of promoter region of SPINT2/HAI-2 gene: an epigenetic mechanism in hepatitis C virus-induced hepatocarcinogenesis.26030814
cervical cancerEpigenetic AlterationsMicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT.26034994
NeoplasmsEpigenetic AlterationsMicroRNA-491-5p (miR-491-5p), an important miRNA, has been demonstrated to be involved in the processes of initiation and progression in several tumors.26034994
Clinical CoordinatorEpigenetic AlterationsWe conducted a systematic discovery and validation of microRNA (miRNA) biomarkers in two clinical trial cohorts of CRC patients.26035698
Clinical Coordinator, NeoplasmsEpigenetic AlterationsWe performed an initial discovery phase using Affymetrix miRNA expression arrays to profile stage III CRC patients with and without tumour recurrence (n=50 per group) at 3-years of follow-up.26035698
Clinical CoordinatorEpigenetic AlterationsDuring validation, we analysed miRNAs using qRT-PCR in an independent cohort of 237 stage II-IV CRC patients treated with 5-FU-based chemotherapy, as well as in normal colonic mucosa from 20 healthy subjects.26035698
Colorectal Cancer Pathway, Colorectal NeoplasmsEpigenetic AlterationsCirculating microRNAs (miRNA) are emerging as promising diagnostic biomarkers for colorectal cancer, but their usefulness for detecting early colorectal neoplasms remains unclear.26038573
Malignant neoplasm of urinary bladderEpigenetic AlterationsIdentification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer.26039340
CarcinogenesisEpigenetic AlterationsWe set out to identify DNA methylation patterns associated with arsenic and its metabolites in exfoliated urothelial cells (EUCs) that originate primarily from the urinary bladder, one of the targets of arsenic-induced carcinogenesis.26039340
Pancreatic carcinomaEpigenetic AlterationsPancreatic cancer patient survival correlates with DNA methylation of pancreas development genes.26039411
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsOur results suggest that THM exposure may affect DNA methylation in genes related to tumors, including colorectal and bladder cancers.26039576
Cerebrovascular accidentEpigenetic AlterationsDifferential Regulation of microRNAs in Patients with Ischemic Stroke.26044809
Cerebrovascular DisordersEpigenetic AlterationsMicroRNAs play an important role in atherosclerosis-related diseases, such as cerebrovascular and cardiovascular disease.26044809
Malignant Neoplasms, Stomach Carcinoma, doxorubicin/mercaptopurine/prednisone/vincristine protocolEpigenetic AlterationsTo elucidate the mechanism of radiation-induced cancers, we analyzed the expression profiles of microRNAs extracted from formalin-fixed paraffin-embedded (FFPE) gastric cancer (GC) tissue samples from atomic bomb survivors.26045155
Stomach CarcinomaEpigenetic AlterationsIdentification of differentially expressed signatures of long non-coding RNAs associated with different metastatic potentials in gastric cancer.26045391
MetastasisEpigenetic AlterationsSeveral long, non-coding RNAs (lncRNAs) play important roles in gastric tumorigenesis and metastasis.26045391
Carcinoma of lung, NeoplasmsEpigenetic AlterationsmicroRNA (mir)-365 exerts tumor suppressor function by targeting thyroid transcription factor-1 (TTF-1) in lung cancer cells.26045746
Liver carcinomaEpigenetic AlterationsHigh expression of long non-coding RNA ANRIL is associated with poor prognosis in hepatocellular carcinoma.26045820
Primary malignant neoplasmEpigenetic Alterationslong non-coding RNA ANRIL (lncRNA ANRIL) has been demonstrated to play a crucial role in cancer progression.26045820
melanomaEpigenetic AlterationsDecreased serum microRNA-206 level predicts unfavorable prognosis in patients with melanoma.26045823
melanoma, NeoplasmsEpigenetic AlterationsMicroRNA-206 (miR-206) acts as a tumor suppressor in melanoma cell lines.26045823
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression and function in tumor development and progression.26046464
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsWe previously identified up-regulated miRNAs in clear cell renal cell carcinoma (ccRCC) compared to matched-pair normal kidney by microarray.26046464
Liver carcinomaEpigenetic AlterationsA Seven-microRNA Expression Signature Predicts Survival in Hepatocellular Carcinoma.26046780
Hollings Cancer CenterEpigenetic AlterationsHowever, limited information is available regarding genome-wide miRNA expression profiles in HCC to generate a tumor-specific miRNA signature of prognostic values.26046780
Malignant NeoplasmsEpigenetic AlterationsThe differential expression of microRNAs (miRNAs) has been associated with the prognosis of various cancers.26046780
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsmiRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers.26048406
DiseaseEpigenetic AlterationsLong noncoding RNA (lncRNA) plays a crucial role in the regulation of various cellular processes and human diseases.26050227
Secondary malignant neoplasm of liver, Colorectal Cancer PathwayEpigenetic AlterationsAberrant expression of long noncoding RNAs in colorectal cancer with liver metastasis.26050227
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsIdentification and characterization of the gene expression profiles for protein coding and non-coding RNAs of pancreatic ductal adenocarcinomas.26053098
Stomach CarcinomaEpigenetic AlterationsHowever little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in gastric cancer.26054683
Stomach Carcinoma, MetastasisEpigenetic AlterationsLong non-coding RNAs (lncRNAs), emerging non-coding RNAs, have been proved to serve as a critical role in the proliferation, metastasis apoptosis of gastric cancer.26054683
Carcinoma of lung, NeoplasmsEpigenetic AlterationsTMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer.26056045
Carcinoma of lung, NeoplasmsEpigenetic AlterationsOur results revealed for the first time that TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is an independent prognostic factor of lung cancer.26056045
Carcinoma of lung, NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumour suppressors contributes to the development and progression of lung cancer.26056045
Embryonal RhabdomyosarcomaEpigenetic AlterationsTwenty transcripts (10 annotated, 10 noncoding RNAs) were significantly differentially expressed in ERMS when compared with PPB samples.26056800
Malignant Head and Neck NeoplasmEpigenetic AlterationsCirculating microRNAs as prognostic therapy biomarkers in head and neck cancer patients.26057452
Squamous cell carcinoma of the head and neckEpigenetic AlterationsAll miRNAs identified as biomarker candidates were then confirmed in an independent validation cohort of HNSCC patients and tested for correlation with the clinical outcome.26057452
Squamous cell carcinoma of the head and neckEpigenetic AlterationsWe identified a signature of eight plasma miRNAs that differentiated significantly (P=0.003) between HNSCC patients and healthy donors.26057452
NeoplasmsEpigenetic AlterationsAll therapy-responsive and patient-specific miRNAs in plasma were also detectable in tumour tissues derived from the same patients.26057452
Squamous cell carcinoma of the head and neck, NeoplasmsEpigenetic AlterationsWe found strong evidence that the circulating therapy-responsive miRNAs are tumour related and were able to validate them in an independent cohort of HNSCC patients.26057452
Primary malignant neoplasmEpigenetic AlterationsBy implementing a triple-filtering approach we identified a subset of highly biologically relevant miRNA-mRNA interactions and we demonstrated that the same genes/pathways affected by somatic mutations in cancer are affected by changes in the abundance of miRNAs.26057471
Primary malignant neoplasmEpigenetic AlterationsTherefore, one important conclusion from our work is that during cancer development, there seems to be a convergence of oncogenic processes driven by somatic mutations and/or miRNA regulation affecting key cellular pathways.26057471
Squamous cell carcinoma of the head and neckEpigenetic AlterationsWe identified, for the first time, a multi-marker signature of 3 major classes of circulating sncRNAs in HNSCC, revealing the presence of circulating novel and known miRNAs, and tRNA- and YRNA-derived small RNAs that were significantly deregulated in the sera of HNSCC patients compared to healthy controls.26057471
Squamous cell carcinomaEpigenetic AlterationsLong non-coding RNA HOTTIP is correlated with progression and prognosis in tongue squamous cell carcinoma.26058875
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been demonstrated to be a critical role in cancer progression and prognosis.26058875
Prostate Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsMicroRNA-205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer.26059417
Primary malignant neoplasmEpigenetic AlterationsRestoration of microRNA-205 in cancer cell lines significantly inhibited cancer cell migration and invasion.26059417
Prostate Cancer PathwayEpigenetic AlterationsOur data showed that the centromere protein F gene was overexpressed in prostate cancer clinical specimens and was a direct target of microRNA-205 regulation.26059417
Prostate Cancer Pathway, Metastasis, Primary malignant neoplasmEpigenetic AlterationsLoss of tumor-suppressive microRNA-205 seems to enhance cancer cell migration and invasion in prostate cancer through direct regulation of centromere protein F. Our data describing pathways regulated by tumor-suppressive microRNA-205 provide new insights into the potential mechanisms of prostate cancer oncogenesis and metastasis.26059417
Glioblastoma Multiforme PathwayEpigenetic AlterationsUnsupervised clustering of mutations and data from RNA, DNA-copy-number, and DNA-methylation platforms uncovered concordant classification of three robust, nonoverlapping, prognostically significant subtypes of lower-grade glioma that were captured more accurately by IDH, 1p/19q, and TP53 status than by histologic class.26061751
Breast CarcinomaEpigenetic AlterationsMicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer.26062455
Breast CarcinomaEpigenetic AlterationsmiRNA profiling studies have suggested that miR-196a is highly overexpressed in breast cancer.26062455
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsMicroRNA-153 is a prognostic marker and inhibits cell migration and invasion by targeting SNAI1 in human pancreatic ductal adenocarcinoma.26062664
Neoplasm MetastasisEpigenetic AlterationsmiR-153 has been suggested as a novel tumor-associated miRNA, which is involved in tumor metastasis.26062664
Metastasis, NeoplasmsEpigenetic AlterationsMounting evidence suggests that microRNAs (miRNAs) act as critical factors for tumor recurrence and metastasis.26062664
Triple-Negative Breast Cancer Finding, NeoplasmsEpigenetic AlterationsTumor tissue microRNA expression in association with triple-negative breast cancer outcomes.26062749
NeoplasmsEpigenetic AlterationsIncorporating the miRNA score with known TNBC outcome predictors, i.e., age at diagnosis, tumor stage, and basal-like subtype, increased the C-index for predicting DFS from 0.68 to 0.74.26062749
Malignant NeoplasmsEpigenetic AlterationsHowever, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers.26063036
Secondary malignant neoplasm of liverEpigenetic AlterationsWhen these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin.26063036
Carcinogenesis, MetastasisEpigenetic AlterationsElucidation of the molecular networks regulated by tumor-suppressive miRNAs will provide insights into the molecular mechanisms of PCa oncogenesis and metastasis.26063484
Malignant NeoplasmsEpigenetic AlterationsInactivation of methylcytosine dioxygenase, ten-eleven translocation (TET) is known to be associated with aberrant DNA methylation in cancers.26063725
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsTumors with a CpG island methylator phenotype (CIMP), a distinct subgroup with extensive DNA methylation, show characteristic features in the case of colorectal cancer.26063725
Colorectal Carcinoma, Colonic PolypsEpigenetic AlterationsFurthermore, DNA methylation profiling, including assessment of the TET1 gene, was assessed in colorectal cancers, as well as colon polyps.26063725
Colorectal CarcinomaEpigenetic AlterationsThe TET1 was silenced by DNA methylation in a subset of colorectal cancers as well as cell lines, expression of which was reactivated by demethylating agent.26063725
Stomach CarcinomaEpigenetic AlterationsCirculating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer.26063956
Stomach CarcinomaEpigenetic AlterationsMicroRNA-21 was upexpressed in gastric cancer (GC) indicating that it is a potential diagnostic biomarker for GC.26063956
Primary malignant neoplasm, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsPatterns of global histone modifications have been recently suggested as outcome predictors in cancer patients, but few studies have been conducted on pancreatic ductal adenocarcinomas (PDACs).26067135
Neoplasms, Cessation of lifeEpigenetic AlterationsEpigenetic deregulation may be involved in tumor cell biology, including differentiation, tumor progression, and cell death, and histone acetylation is a major regulatory mechanism of gene transcription.26067135
Degenerative polyarthritisEpigenetic AlterationsWe report novel findings that DNA methylation regulates SOSTs expression in OA, by changing Smad 1/5/8 binding affinity to SOST promoter, providing evidence that changes in DNA methylation pattern could underlie changes in genes expression observed in OA.26071314
Feel PainEpigenetic AlterationsAnalgesic Response to Intravenous Ketamine Is Linked to a Circulating microRNA Signature in Female Patients With Complex Regional Pain Syndrome.26072390
Carcinogens, NeoplasmsEpigenetic AlterationsThe best known and more frequent epigenetic alteration is DNA methylation affecting tumor suppressor genes that may be involved in various carcinogenetic pathways.26073472
CarcinogenesisEpigenetic AlterationsGastric carcinogenesis is a multistep process including not only genetic mutations but also epigenetic alterations.26073472
Stomach CarcinomaEpigenetic AlterationsSerum RASSF1A and APC promoter hypermethylation is a frequent epigenetic event in patients with early operable gastric cancer.26073472
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is the most common and well-characterized epigenetic change in human cancer.26074659
methionine, Secondary malignant neoplasm of lungEpigenetic AlterationsComprehensive gene and microRNA expression profiling reveals miR-206 inhibits MET in lung cancer metastasis.26075299
methionineEpigenetic AlterationsOne of its predicted targets in our miRNA-gene network, MET, was also obviously decreased at the protein level when miR-206 was overexpressed.26075299
Secondary malignant neoplasm of lung, methionineEpigenetic AlterationsIn conclusion, our study provided a miRNA-gene regulatory network in lung cancer metastasis and further demonstrated the roles of miR-206 and MET in this process, which enhances the understanding of the regulatory mechanism in lung cancer metastasis.26075299
Carcinoma of lung, MetastasisEpigenetic AlterationsMiRNAs associated with the metastasis of lung cancer remain largely unexplored.26075299
Carcinoma of lungEpigenetic AlterationsUsing the qRT-PCR method, the six miRNAs were further confirmed to show a significant expression difference between human lung cancer and normal tissue samples.26075299
Malignant Neoplasms, DICER1 protein, humanEpigenetic AlterationsDicer is a key enzyme in miRNA processing pathway, and dysregulation of its expression has been suggested as a possible cause of miRNAome alterations observed in various cancers.26076803
Primary malignant neoplasmEpigenetic AlterationsThere is an urgent need of comprehensive longitudinal analyses of circulating miRNA patterns to identify dynamic changes of miRNAs in cancer patients after surgery.26078336
NeoplasmsEpigenetic AlterationsThis analysis provided further evidence of miRNA plasma levels that are changing over time after tumor resection and correlate to patient outcome.26078336
Psychotic DisordersEpigenetic AlterationsNew epigenetic technologies may uncover etiopathogenic mechanisms of major psychosis.26078387
Mental disordersEpigenetic AlterationsOur findings revealed new epigenetic complexities but also highlighted the potential of DNA modification approaches in the search of heterogeneous causes of major psychiatric disease.26078387
Prostate Cancer PathwayEpigenetic AlterationsStability Assessment of Candidate Reference Genes in Urine Sediment of Prostate Cancer Patients for miRNA Applications.26078486
Squamous cell carcinoma of esophagusEpigenetic AlterationsDownregulation of microRNA-382 is associated with poor outcome of esophageal squamous cell carcinoma.26078564
Carcinoma of lungEpigenetic AlterationsPlasma circulating microRNA-944 and microRNA-3662 as potential histologic type-specific early lung cancer biomarkers.26079400
NeoplasmsEpigenetic AlterationsPossibility of detection of miRNA expression in patients plasma or serum makes them valuable biomarkers of different neoplasms.26079400
Carcinoma of lungEpigenetic AlterationsHigher stage of lung cancer correlated with higher miRNA expressions.26079400
Malignant NeoplasmsEpigenetic AlterationsAltered expression of microRNAs (miRNAs) is associated with the development and invasion of cancers by regulating post-transcriptionally gene function.26079400
TSPYL2 wt Allele, NeoplasmsEpigenetic AlterationsMultiple mutations were identified that affected the same pathways, including epigenetic, cell-fate regulation, and cytokine signaling, in MF tumors and CTCL cell lines.26082451
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsOne microRNA (miR-34c-5p) was validated as significantly over-expressed in T2D monocytes.26083362
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsThe expression profile of microRNAs/mRNAs in monocytes of T2D patients indicates an altered adhesion, differentiation, and shape change potential.26083362
Myeloid Leukemia, ChronicEpigenetic AlterationsAberrant DNA methylation of various genes has been identified to be associated with disease progression in chronic myeloid leukemia (CML).26086097
Myeloid Leukemia, ChronicEpigenetic AlterationsEpigenetic inactivation of DLX4 is associated with disease progression in chronic myeloid leukemia.26086097
Prostate Cancer PathwayEpigenetic AlterationsDNA Methylation-Guided Prediction of Clinical Failure in High-Risk Prostate Cancer.26086362
CHOANAL ATRESIA, POSTERIOR, NeoplasmsEpigenetic AlterationsClassification of primary high-risk tumors into three subtypes based on DNA methylation can be combined with clinico-pathological parameters for a more informative risk-stratification of these PCa patients.26086362
Cardiac HypertrophyEpigenetic AlterationsBlood-based microRNA signatures differentiate various forms of cardiac hypertrophy.26086795
AcromegalyEpigenetic AlterationsWe also identified several novel transcriptional changes, some of which may be important for GH/IGF responses (PTPN3 and PTPN4) and the effects of acromegaly on growth and proliferation.26087292
Malignant NeoplasmsEpigenetic AlterationsDNA methylation has been reported in many cancers, suggesting that it can be utilized as an early biomarker to improve the early diagnosis rate.26090379
Degenerative polyarthritisEpigenetic AlterationsThe Long Noncoding RNA MEG3 Is Downregulated and Inversely Associated with VEGF Levels in Osteoarthritis.26090403
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsWe used ELISA and immunohistochemistry tests to analyze 5-hmC status in ESCC tissues, RT-qPCR to analyze TET family mRNA expression in normal and tumor tissues, and pyrosequencing to quantify LINE-1 (i.e., global DNA methylation) levels.26093090
Injury of pancreasEpigenetic AlterationsA pancreatic miRNA signature can be useful for assessment of pancreatic injury in the acute phase of AP.26094040
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsDecreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma.26097558
Malignant NeoplasmsEpigenetic Alterationsaccumulating evidence suggest that long non-coding RNAs (lncRNAs) may play important roles in human cancers.26097558
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsEpigenetic and genetic alteration plays a major role to the development of head and neck squamous cell carcinoma (HNSCC).26098903
DiseaseEpigenetic AlterationsAlthough DNA methylation is now recognized as an important mediator of complex diseases, the extent to which the genetic basis of such diseases is accounted for by DNA methylation is unknown.26101197
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsNovel epigenetic determinants of type 2 diabetes in Mexican-American families.26101197
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsOur study has identified novel epigenetic indicators of T2D risk in Mexican Americans who have increased risk for this disease.26101197
Squamous cell carcinoma, Neoplasm MetastasisEpigenetic AlterationsWe corroborate literature data on the role of small RNAs in cancer metastasis and suggest the detection of microRNAs as a tool that may assist in the evaluation of oral squamous cell carcinoma metastatic potential.26104160
Colorectal CarcinomaEpigenetic AlterationsEpigenetics could explain some Moroccan population colorectal cancers peculiarities: microsatellite instability pathway exploration.26104511
Adenocarcinoma of lung (disorder)Epigenetic AlterationsThe expression of microRNA-34a is inversely correlated with c-MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients.26104764
Malignant tumor of colon, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts.26105520
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNAs (miRs) are proposed as colorectal cancer (CRC) biomarkers.26105520
Prostate Cancer PathwayEpigenetic AlterationsMechanistically, this was associated with epigenetics silencing of the MIR34B/C locus and increased DNA copy number loss, selectively in androgen-dependent prostate cancer.26107383
Prostate Cancer Pathway, AdenocarcinomaEpigenetic AlterationsHere, we used an integrated discovery platform combining prostate cancer cell lines, a Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model and clinically-annotated human tissue samples to identify loss of expression of microRNA-34b as consistently associated with prostate cancer relapse.26107383
T-Cell Prolymphocytic LeukemiaEpigenetic AlterationsEpigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia.26109102
malignant diseaseEpigenetic AlterationsAging is associated with highly reproducible DNA methylation (DNAm) changes, which may contribute to higher prevalence of malignant diseases in the elderly.26110659
Primary malignant neoplasmEpigenetic AlterationsEpigenetic Aging Signatures Are Coherently Modified in Cancer.26110659
Primary malignant neoplasmEpigenetic AlterationsIn this study, we analyzed epigenetic aging signatures in 5,621 DNAm profiles of 25 cancer types from The Cancer Genome Atlas (TCGA).26110659
Leukemia, Myelocytic, AcuteEpigenetic AlterationsFor example, in acute myeloid leukemia (AML) higher epigenetic age-predictions are associated with increased incidence of mutations in RUNX1, WT1, and IDH2, whereas mutations in TET2, TP53, and PML-PARA translocation are more frequent in younger age-predictions.26110659
Esophageal carcinoma, Chromophobe Renal Cell Carcinoma, Squamous cell carcinoma of lung, Glioblastoma Multiforme Pathway, Glioblastoma Multiforme, Primary malignant neoplasm, melanoma, Neuroendocrine TumorsEpigenetic AlterationsFurthermore, epigenetic aging signatures correlate with overall survival in several types of cancer (such as lower grade glioma, glioblastoma multiforme, esophageal carcinoma, chromophobe renal cell carcinoma, cutaneous melanoma, lung squamous cell carcinoma, and neuroendocrine neoplasms).26110659
Primary malignant neoplasmEpigenetic AlterationsFurthermore, the apparent epigenetic age-predictions correlate with clinical parameters and overall survival in several types of cancer, indicating that regulation of DNAm patterns in age-associated CpGs is relevant for cancer development.26110659
Rheumatoid Arthritis, Right armEpigenetic AlterationsAlterations in DNA methylation contribute to the abnormal phenotype of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA).26111028
Lung NeoplasmsEpigenetic AlterationsHigh percentage of lung tumor samples with simultaneous RASSF1A decreased expression and gene promoter methylation indicates its epigenetic silencing.26112163
Breast CarcinomaEpigenetic AlterationsWe and others have previously reported widespread changes in DNA methylation using breast cancer cell line models of endocrine resistance.26113056
Breast CarcinomaEpigenetic AlterationsIn summary, our studies show, for the first time, that overexpression of histone variants might be important in endocrine response in ER+ breast cancer, and that overexpression is at least in part mediated via epigenetic mechanisms and amplifications.26113056
Diabetic Retinopathy, diabeticEpigenetic AlterationsExpression of Angiogenic MicroRNAs in Endothelial Progenitor Cells From Type 1 Diabetic Patients With and Without Diabetic Retinopathy.26114486
Pancreatic carcinomaEpigenetic AlterationsTo identify plasma microRNA (miRNA) markers of pancreatic cancer (PC).26114496
Primary malignant neoplasmEpigenetic AlterationsEpigenetic reprogramming that imparts functional changes in gene expression, the development of cancer stem cells, and immunomodulation are plausible underlying mechanisms by which early-life iAs exposure elicits latent carcinogenic effects.26115410
Myeloproliferative disease, MyelofibrosisEpigenetic AlterationsUp-regulation of MicroRNA 146b is Associated with Myelofibrosis in Myeloproliferative Neoplasms.26116595
Uterine Cervical Neoplasm, Human papilloma virus infectionEpigenetic AlterationsDifferent DNA methylation pattern of HPV16, HPV18 and HPV51 genomes in asymptomatic HPV infection as compared to cervical neoplasia.26119875
cervical cancerEpigenetic AlterationsAn increased DNA methylation level of HPV16 promoter region in case of cervical cancer was determined.26119875
Malignant Neoplasms, Stomach CarcinomaEpigenetic AlterationsTo improve the outcome of patients suffering from gastric cancer, a better understanding of underlying genetic and epigenetic events in this malignancy is required.26121593
Pancreatic carcinomaEpigenetic AlterationsSalivary MicroRNA in Pancreatic Cancer Patients.26121640
Primary malignant neoplasmEpigenetic AlterationsIn experimental models of PDAC, salivary microRNA detection precedes systemic detection of cancer cells markers.26121640
Primary malignant neoplasmEpigenetic AlterationsIn addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers.26121640
Breast CarcinomaEpigenetic AlterationsAssociations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population.26125831
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsSingle-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer.26125831
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsEpigenetic silencing of the GSTP1 gene by promoter methylation has been associated with increased risk and shortened survival in patients with hepatocellular carcinoma (HCC).26125884
Squamous cell carcinoma, NeoplasmsEpigenetic AlterationsDecreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma.26125902
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-143 serves as a tumor suppressor in many human malignancies.26125902
CHOANAL ATRESIA, POSTERIOR, Hormone refractory prostate cancerEpigenetic AlterationsTherefore, it was concluded that gene transcription and protein expression of YAP may be involved in the development of PCa, particularly CRPC, and may be a novel biomarker for investigation of the occurrence and progression of CRPC.26126522
Acute leukemiaEpigenetic AlterationsMicroRNAs (miRs), small endogenous noncoding RNAs, play an essential role in the development and progression of acute leukemia.26126974
Leukemia, Myelocytic, AcuteEpigenetic AlterationsLow expression of microRNA-204 (miR-204) is associated with poor clinical outcome of acute myeloid leukemia (AML) patients.26126974
NeoplasmsEpigenetic AlterationsFurthermore, high microRNA-122 expression (hazard ratio [HR]=2.67; 95% confidence interval [CI]=1.12-6.35; P=0.026) and advanced tumor stage (HR=2.27; 95% CI=1.23-4.18; P=0.009) were independent risk factors for poor OS in patients treated with RFA.26129878
NeoplasmsEpigenetic AlterationsThe combination of microRNA-122 and tumor stage resulted in an area under the curve of 0.818 for predicting 1-year OS in patients who underwent RFA.26129878
Adenocarcinoma of lung, stage IEpigenetic AlterationsAn Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers.26134223
Adenocarcinoma of lung (disorder)Epigenetic AlterationsGenome-wide screening of DNA methylation and pyrosequencing analysis of HOXA9 promoter methylation were performed in two independently collected cohorts of stage I lung adenocarcinoma.26134223
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are a type of small non-coding RNA molecule that play important roles in tumor initiation, chemotherapy response, promotion, and progression by negatively interfering with gene expression.26134365
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in cervical carcinogenesis and progression.26134491
Malignant NeoplasmsEpigenetic AlterationsmicroRNA-133a (miR-133a) has been reported to play a tumor-suppressor role in a range of cancers.26134491
Inflammation, NeoplasmsEpigenetic AlterationsChronic inflammation as an important epigenetic and environmental factor for putative tumorigenesis and tumor progression may be associated with specific activation of Toll-like receptors (TLR).26134824
Psoriasis, HyperplasiaEpigenetic AlterationsNF-kB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis.26138368
Psoriatic Juvenile Idiopathic ArthritisEpigenetic AlterationsHere we report that the NF-kB activation triggered by inflammatory cytokines induces the transcription of microRNA (miRNA) miR-31, one of the most dynamic miRNAs identified in the skin of psoriatic patients and mouse models.26138368
Malignant neoplasm of urinary bladderEpigenetic AlterationsIntegrative functional genetic-epigenetic approach for selecting genes as urine biomarkers for bladder cancer diagnosis.26138586
Metastasis, Adenocarcinoma of lung (disorder)Epigenetic AlterationsDetection of the long noncoding RNAs nuclear-enriched autosomal transcript 1 (NEAT1) and metastasis associated lung adenocarcinoma transcript 1 in the peripheral blood of HIV-1-infected patients.26139386
Malignant neoplasm of breast, Mammary NeoplasmsEpigenetic AlterationsMiR-190b, the highest up-regulated miRNA in ERa-positive compared to ERa-negative breast tumors, a new biomarker in breast cancers?26141719
Breast CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) show differential expression across breast cancer subtypes and have both oncogenic and tumor-suppressive roles.26141719
Malignant neoplasm of breastEpigenetic AlterationsWe used the robust and reproductive tool of quantitative RT-PCR in a large cohort of well-annotated 153 breast cancers with long-term follow-up to identify miRNAs specifically differentially expressed between ER(+) and ER(-) breast cancers.26141719
Malignant neoplasm of breastEpigenetic AlterationsWe identified a robust collection of 20 miRNAs significantly deregulated in ER(+) compared to ER(-) breast cancers : 12 up-regulated and eight down-regulated miRNAs.26141719
Carcinoma of lungEpigenetic AlterationsDifferential miRNA expressions in peripheral blood mononuclear cells for diagnosis of lung cancer.26146958
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTremendous efforts have been made to develop cancer biomarkers by detecting circulating extracellular miRNAs directly released from tumors.26146958
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe first used a microarray to analyze PBMCs of 16 stage I NSCLC patients and 16 cancer-free smokers, and identified seven PBMC miRNAs with a significantly altered expression level in NSCLC patients.26146958
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn a training set of 84 NSCLC patients and 69 cancer-free smokers, a panel of two miRNAs (miRs-19b-3p and -29b-3p) were developed from the seven PBMC miRNAs, producing 72.62% sensitivity and 82.61% specificity in identifying NSCLC.26146958
Squamous cell carcinoma of lung, Non-Small Cell Lung CarcinomaEpigenetic AlterationsFurthermore, the miRNAs could identify squamous cell lung carcinoma (SCC), a major type of NSCLC, with 80.00% sensitivity and 89.86% specificity.26146958
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe assessment of PBMC miRNAs may provide a new diagnostic approach for the early detection of NSCLC.26146958
GTP-Binding Nuclear Protein Ran, Human, Colorectal Cancer PathwayEpigenetic Alterations3-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.26147304
InitiationEpigenetic AlterationsMicroRNAs play an important role in cancer initiation and development.26147304
ManicEpigenetic AlterationsWe conclude that mania is associated with alterations in levels of DNA methylation and inflammatory markers.26147665
Mood DisordersEpigenetic AlterationsSince epigenetic markers are potentially malleable, a better understanding of the role of epigenetics may lead to new methods for the prevention and treatment of mood disorders.26147665
Primary malignant neoplasmEpigenetic AlterationsEpigenetic changes play significant roles in cancer development.26147747
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsUHRF1, an epigenetic regulator, has been shown to be overexpressed and to coordinate tumor suppressor gene (TSG) silencing in several cancers.26147747
melanoma, Cessation of lifeEpigenetic AlterationsExpression and clinicopathological significance of microRNA-21 and programmed cell death 4 in malignant melanoma.26150475
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA 211 expression is upregulated and associated with poor prognosis in colorectal cancer: a case-control study.26152286
Breast CarcinomaEpigenetic AlterationsIn conclusion, our findings further implicate "metabolic" genes or pathways in breast cancer that are disrupted by epigenetic mechanisms and could provide new avenues for understanding this disease in a new context.26152288
Primary malignant neoplasmEpigenetic AlterationsBridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis.26152361
PsychiatricEpigenetic AlterationsThe results support increasing optimism that epigenetic regulation of key neuroendocrine systems might help explain hitherto unfathomable individual differences in susceptibility to psychiatric symptom profiles.26152664
Laryngeal Squamous Cell Carcinoma, Primary malignant neoplasmEpigenetic AlterationsAltered microRNA expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC).26153151
Carcinoma of lungEpigenetic AlterationsHigh copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer.26156018
Primary malignant neoplasmEpigenetic AlterationsIn conclusion, our results show that copy number variation may be an important mechanism of upregulation/downregulation of miRNAs in cancer and suggest an oncogenic role for DROSHA.26156018
Admitting diagnosisEpigenetic AlterationsRecently it has been shown that aberrant epigenetic processes including acetylation are associated with the development of AD.26159193
Alzheimers DiseaseEpigenetic AlterationsWe examined whether altered DNA methylation of the MAPT promoter, with its potential to modulate gene expression, was a common phenomenon in Alzheimers disease patients with differing aetiologies.26159201
Squamous cell carcinoma of lungEpigenetic AlterationsGenome-scale long noncoding RNA expression pattern in squamous cell lung cancer.26159226
Metastatic hepatocellular carcinomaEpigenetic AlterationsLong non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition.26160837
Primary malignant neoplasmEpigenetic AlterationsIncreasing evidence indicates that long non-coding RNAs (lncRNAs) regulate diverse cellular processes, including cell growth, differentiation, apoptosis, and cancer progression.26160837
NeoplasmsEpigenetic AlterationsLethal-7 (let-7) is a tumour suppressor miRNA which acts by down-regulating several oncogenes including KRAS.26162609
Hypertensive diseaseEpigenetic AlterationsDownregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension.26162916
FailureEpigenetic AlterationsThere is growing evidence that angiogenesis and microRNAs are involved in PAH-associated RV failure.26162916
FractureEpigenetic AlterationsSerum Circulating MicroRNAs as Biomarkers of Osteoporotic Fracture.26163235
Diffuse SclerodermaEpigenetic AlterationsFour (miRNA-223, -181b, -342-3p and -184) were differently expressed in lcSSc and dcSSc (false discovery rate < 0.05).26163687
Diffuse SclerodermaEpigenetic AlterationsCirculating miRNA profiles differ between lcSSc and dcSSc patients and between patients with different autoantibodies.26163687
Autoimmune DiseasesEpigenetic AlterationsThis is the first time autoantibody profiles, disease phenotypes and plasma miRNA profiles have been shown to correlate in an autoimmune disease.26163687
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe YAP1 oncogene contributes to bladder cancer cell proliferation and migration by regulating the H19 long noncoding RNA.26163939
Malignant Neoplasms, Malignant neoplasm of urinary bladderEpigenetic AlterationsYes-associated protein 1 (YAP1) and long noncoding RNA H19 act as potent oncogenes in many human cancers, but little is known about their roles in bladder cancer or their relationship with each other.26163939
Crohn DiseaseEpigenetic AlterationsMicroRNAs Classify Different Disease Behavior Phenotypes of Crohns Disease and May Have Prognostic Utility.26164662
InflammationEpigenetic AlterationsWe found a suite of miRNAs, including miR-31-5p, miR-215, miR-223-3p, miR-196b-5p, and miR-203 that stratify patients with CD according to disease behavior independent of the effect of inflammation.26164662
Right armEpigenetic AlterationsHere, we show that TXNDC5 is directly targeted by microRNA (miR)-573, and TXNDC5, in turn, mediates the suppressive effect of miR-573 on the invasion of synovial fibroblasts of RA (RASFs).26166764
Muscle, Smooth, VascularEpigenetic AlterationsMicroRNA-1 regulates the proliferation of vascular smooth muscle cells by targeting insulin-like growth factor 1.26166810
Breast CarcinomaEpigenetic AlterationsDNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer.26169690
Breast CarcinomaEpigenetic AlterationsHere we characterize the DNA methylome of endocrine sensitivity and demonstrate the potential impact of differential DNA methylation on endocrine response in breast cancer.26169690
Adenocarcinoma of lung (disorder)Epigenetic AlterationsUnique microRNAs in lung adenocarcinoma groups according to major TKI sensitive EGFR mutation status.26170125
Malignant Neoplasms, Carcinoma of lungEpigenetic AlterationsAltered expression of microRNAs(miRNAs) in human malignancies have been well recognized as diagnostic and prognostic indicators, including lung cancer.26170125
NeoplasmsEpigenetic AlterationsHigher expression levels of three miRNAs were positively related to poor tumor differentiation.26170125
Adenocarcinoma of lung (disorder)Epigenetic AlterationsConsequently, further studies of the biology of miRNAs may lead to diagnostic and prognostic biomarkers in pulmonary adenocarcinoma.26170125
ProgeriaEpigenetic AlterationsCells from HGPS patients show several nuclear abnormalities including aberrant morphology, nuclear stiffening and loss of epigenetic modifications including heterochromatin territories.26171741
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsMiRNAs are deregulated in different tumors including gastric cancer (GC) and have potential diagnostic and prognostic implications.26172537
Stomach CarcinomaEpigenetic AlterationsMicroRNA-18a modulates P53 expression by targeting IRF2 in gastric cancer patients.26173586
Stomach CarcinomaEpigenetic AlterationsMicroRNA-18a (miR-18a) has been reported to be upregulated in gastric cancer (GC) tissues compared with normal gastric tissues.26173586
Parkinson DiseaseEpigenetic AlterationsL-dopa increases a-synuclein DNA methylation in Parkinsons disease patients in vivo and in vitro.26173746
Colorectal Cancer PathwayEpigenetic AlterationsThe potential role of microRNA-31 expression in early colorectal cancer.26173758
Malignant Neoplasms, Colorectal Cancer PathwayEpigenetic AlterationsThe expression of microRNA-31 (miR-31) has been implicated in the progression of some human malignancies including colorectal cancer.26173758
Primary malignant neoplasmEpigenetic AlterationsOxidative stress related DNA methylation may therefore be associated (causally or as a by-product) with cancer.26173806
Primary malignant neoplasmEpigenetic AlterationsIn the ESTHER baseline sample, the hazard ratio for cancer development in 11 years of follow-up comparing bottom and top quartile of DNA methylation at cg10342304 was 1.86 (95%-confidence-interval 1.01-3.43).26173806
Primary malignant neoplasmEpigenetic AlterationsDiscovery of a novel epigenetic cancer marker related to the oxidative status of human blood.26173806
Primary malignant neoplasmEpigenetic AlterationsIf the observed CpG-cancer association can be successfully replicated by other studies, this epigenetic marker could be an interesting biomarker of cancer risk.26173806
Myocardial IschemiaEpigenetic AlterationsMicroRNAs (miRNAs) play a significant role in ischemic heart disease.26175501
Primary malignant neoplasmEpigenetic AlterationsCorrelation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer.26181258
Primary malignant neoplasmEpigenetic AlterationsUnderstanding the origin and inheritance of epimutations is important for assessing cancer risk in affected families.26181641
Primary malignant neoplasmEpigenetic AlterationsConstitutional hypermethylation of 1 allele throughout the soma (constitutional epimutation) is an accepted mechanism of cancer predisposition.26181641
Colorectal Cancer PathwayEpigenetic AlterationsWe report a 29-year-old man with early-onset colorectal cancer who showed a constitutional MLH1 epimutation (approximately 50% of alleles methylated and allele-specific loss of MLH1 expression) that was stable over a 16-year period.26181641
Primary malignant neoplasmEpigenetic AlterationsMosaic Epigenetic Inheritance as a Cause of Early-Onset Colorectal Cancer.26181641
Sjogrens Syndrome", Autoimmune Diseases, Perceived stress scale, Lupus ErythematosusEpigenetic AlterationsBeyond genetics, epigenetics alterations and especially those related to DNA methylation, play key roles in the pathogenesis of autoimmune diseases such as primary Sjogrens syndrome (pSS) and systemic lupus erythematosus.26183421
Non-Small Cell Lung CarcinomaEpigenetic AlterationsA potential signature of eight long non-coding RNAs predicts survival in patients with non-small cell lung cancer.26183581
Primary malignant neoplasmEpigenetic AlterationsAccumulated evidence suggests that dysregulated expression of long non-coding RNAs (lncRNAs) may play a critical role in tumorigenesis and prognosis of cancer, indicating the potential utility of lncRNAs as cancer prognostic or diagnostic markers.26183581
Primary malignant neoplasmEpigenetic AlterationsJARID1B is an epigenetic factor with reported oncogenic potential in various cancer types.26184998
Leukemia, Myelocytic, AcuteEpigenetic AlterationsLow expression of circulating microRNA-328 is associated with poor prognosis in patients with acute myeloid leukemia.26185105
Hollings Cancer CenterEpigenetic AlterationsAs we reported previously, microRNA-491 (miR-491) is lower expressed in poorly differentiated HCC tissues relative to well-differentiated HCC tissues.26188902
Hepatitis, Fibrosis Assessment, Hepatitis C, Fibrosis, LiverEpigenetic AlterationsmicroRNA changes in liver tissue associated with fibrosis progression in patients with hepatitis C. Accumulating evidence indicates that microRNAs play a role in a number of disease processes including the pathogenesis of liver fibrosis in hepatitis C infection.26189820
Fibrosis AssessmentEpigenetic AlterationsOur goal is to add to the accruing information regarding microRNA deregulation in liver fibrosis to increase our understanding of the underlying mechanisms of pathology and progression.26189820
Hepatitis C, Fibrosis AssessmentEpigenetic AlterationsWe used next generation sequencing to profile all detectable microRNAs in liver tissue and serum from patients with hepatitis C, stages F1-F4 of fibrosis.26189820
Hepatitis C, Fibrosis AssessmentEpigenetic AlterationsWe found altered expression of several microRNAs, in particular, miR-182, miR199a-5p, miR-200a-5p and miR-183 were found to be significantly upregulated in tissue from liver biopsies of hepatitis C patients with advanced fibrosis, stage F3 and F4, when compared with liver biopsies from patients with early fibrosis, stages F1 and F2.26189820
Fibrosis AssessmentEpigenetic AlterationsWe also found miR-148-5p, miR-1260b, miR-122-3p and miR-378i among the microRNAs most significantly down-regulated from early to advanced fibrosis of the liver.26189820
Fibrosis AssessmentEpigenetic AlterationsAdding measurements of tissue microRNAs acquired during routine biopsies will continue to increase our knowledge of underlying mechanisms of fibrosis.26189820
Liver carcinomaEpigenetic AlterationsClinical implication of long non-coding RNA NEAT1 expression in hepatocellular carcinoma patients.26191242
Malignant NeoplasmsEpigenetic AlterationsNEAT1 (nuclear paraspeckle assembly transcript 1, also known as MENe/b), a novel long non-coding RNA (lncRNA), serves as a crucial regulator in several cancers.26191242
Stomach CarcinomaEpigenetic AlterationsDownregulation of long noncoding RNA ZMAT1 transcript variant 2 predicts a poor prognosis in patients with gastric cancer.26191264
Solitary Pulmonary NoduleEpigenetic AlterationsMicroRNA-144 regulates proliferation, invasion, and apoptosis of cells in malignant solitary pulmonary nodule via zinc finger E-box-binding homeobox 1.26191328
NeoplasmsEpigenetic AlterationsRecurrent mutations were most frequently located in the RNA helicase gene DDX3X (21/105 subjects, 20.0%), tumor suppressors (TP53 and MGA), JAK-STAT-pathway molecules (STAT3 and STAT5B) and epigenetic modifiers (MLL2, ARID1A, EP300 and ASXL3).26192917
Breast CarcinomaEpigenetic AlterationsEpigenetic Inactivation of BRCA1 Through Promoter Hypermethylation and Its Clinical Importance in Triple-Negative Breast Cancer.26195437
Breast CarcinomaEpigenetic AlterationsThe epigenetic inactivation of BRCA1 expression might thus play an important role in sporadic breast cancer cases.26195437
Malignant neoplasm of urinary bladder, MetastasisEpigenetic AlterationsLong noncoding RNA 19 (H19) has been shown to promote bladder cancer cell proliferation and metastasis.26198047
Acute myocardial infarctionEpigenetic AlterationsExpression of circulating microRNAs in patients with ST segment elevation acute myocardial infarction.26198874
MetastasisEpigenetic AlterationsmiRNA-197 and miRNA-184 are associated with brain metastasis in EGFR-mutant lung cancers.26199015
Carcinoma of lungEpigenetic AlterationsMicroRNAs (miRNAs) are frequently deregulated in lung cancer.26199015
Stomach Carcinoma, Neoplasm MetastasisEpigenetic AlterationsTogether, our results imply that loss of RACK1 in gastric cancer links epigenetics to inflammatory cytokines to promote tumor metastasis.26199092
NeoplasmsEpigenetic AlterationsmicroRNA (miRNA; miR) array identified that RACK1 modulated the expression of a series of miRNAs, including the miR-302 cluster, and RACK1 modulated the IL8 expression and tumor invasion through miRNA-302c.26199092
Carcinoma of lung, Lung diseasesEpigenetic AlterationsEpigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer.26200272
Carcinoma of lungEpigenetic AlterationsIn conclusion, we identified a serum 4-miRNA signature that discriminated with high accuracy lung cancer patients from NC.26202143
Pulmonary HypertensionEpigenetic Alterationsrs2910164 Polymorphism Confers a Decreased Risk for Pulmonary Hypertension by Compromising the Processing of microRNA-146a.26202355
Sebaceous adenoma, Sebaceous AdenocarcinomaEpigenetic AlterationsSebaceous carcinoma exhibits an miRNA expression profile distinct from that of sebaceous adenoma, implicating dysregulation of NF-kB and PTEN (targets of miR-486-5p) and TGF-b signaling (target of miR-211) in the pathogenesis of sebaceous carcinoma.26203913
Sebaceous AdenocarcinomaEpigenetic AlterationsDistinct pathways in the pathogenesis of sebaceous carcinomas implicated by differentially expressed microRNAs.26203913
Sebaceous adenoma, Sebaceous Adenocarcinoma, Ocular Sebaceous CarcinomaEpigenetic AlterationsTo describe differentially expressed microRNAs (miRNAs) in a series of periocular sebaceous carcinomas compared with sebaceous adenomas in order to identify pathways driving the pathogenesis of sebaceous carcinoma.26203913
Sebaceous adenoma, Sebaceous AdenocarcinomaEpigenetic AlterationsSerial testing and validation confirmed overexpression of 2 miRNAs previously reported to be oncogenic, miR-486-5p (4.4-fold; P = 2.4 x 10-8) and miR-184 (3.5-fold; P = 1.7 x 10-6), in sebaceous carcinoma compared with sebaceous adenoma and downregulation of 2 miRNAs previously reported to have tumor-suppressive properties, miR-211 (-5.8-fold; P = 2.3 x 10-9) and miR-518d (-4.5-fold; 6.7 x 10-5), in sebaceous carcinoma compared with sebaceous adenoma.26203913
Sebaceous adenoma, Sebaceous AdenocarcinomaEpigenetic AlterationsThe identification of miRNAs whose expression is altered in sebaceous carcinoma compared with sebaceous adenoma provides a novel entry point for a more comprehensive understanding of the molecular-genetic alterations pivotal to the development of sebaceous carcinoma.26203913
Concomitant Medication Submission DomainEpigenetic AlterationsWe identified five miRNAs (miR-1225-5p, miR-320c, miR-1202, miR-1207-5p, and miR-4270) with high expression in MA samples, the PLF of serosa-invasive GC, and the CM of a highly metastatic GC cell line; these candidate miRNA species appear to be related to peritoneal dissemination.26208314
Stomach Carcinoma, MetastasisEpigenetic AlterationsExosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer.26208314
Metastasis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe microRNA-1246 promotes metastasis in non-small cell lung cancer by targeting cytoplasmic polyadenylation element-binding protein 4.26209100
CHOANAL ATRESIA, POSTERIOR, human papillomavirusEpigenetic AlterationsIn 129 PCa patients who underwent ultrasound-guided needle prostate biopsy and subsequent radical prostatectomy from 1987 to 1999 at the University Hospital of Careggi, we evaluated: (1) mRNA expression of the serine 2 (TMPRSS2): erythroblastosis virus E26 oncogene homolog (ERG); (2) expression of matrix metalloproteinases (MMP)-2 and 9 (epithelial and stromal); (3) expression of androgen receptor; (4) expression of prognostic marker Ki67 (MIB1); (5) presence and typing of human papilloma virus; (6) DNA methylation of CpG islands of several genes involved in PCa progression.26210155
Primary malignant neoplasmEpigenetic AlterationsAccumulating evidence indicates that dysregulated microRNA-3651(miR-3651) is involved in tumorigenesis and cancer progression.26210449
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCombination of serum miRNAs with Cyfra21-1 for the diagnosis of non-small cell lung cancer.26213369
Primary malignant neoplasmEpigenetic AlterationsIt has been proposed that miRNA expression studies might be used as diagnostic, prognostic marker in cancer.26214773
ChondrosarcomaEpigenetic AlterationsmiRNA expression data produced in our study may contribute future chondrosarcoma diagnosis and therapy.26214773
Disease, Primary malignant neoplasmEpigenetic AlterationsDysregulated expression of many miRNAs has also been associated with multiple human diseases, such as cancer.26214773
Clinical CoordinatorEpigenetic AlterationsA newly proposed integrated pathway comprising traditional, alternate, and serrated pathways by genetic and epigenetic factors was defined recently and hypothesized to play a role in the pathogenesis of CRC; however, to the authors knowledge, there is a paucity of information regarding these proposed molecular pathways in different ethnic groups.26218848
MS geneEpigenetic AlterationsLayered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals.26220975
Adenocarcinoma Of EsophagusEpigenetic AlterationsMicroRNA-330-5p as a Putative Modulator of Neoadjuvant Chemoradiotherapy Sensitivity in Oesophageal Adenocarcinoma.26221725
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNA/miR) function to regulate gene and protein expression and play a causal role in cancer development and progression.26221725
Carcinoma of lungEpigenetic AlterationsFifty miRNAs previously ranked for their ability to distinguish lung cancer tissue from normal were assayed by RT-qPCR using 45 paired tumor-normal samples.26223535
NeoplasmsEpigenetic AlterationsNovel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been confirmed to play crucial regulatory roles in tumor progression.26224446
SERPINB3 wt AlleleEpigenetic AlterationsAccording to microRNA array, 16 miRNAs were upregulated and 10 were downregulated in OSCC patient sera.26224475
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsDeregulation of microRNAs (miRNAs) is essential to tumor development, and serum miRNA profiles have been reported in several cancers.26224475
Pulmonary arterial hypertensionEpigenetic AlterationsBromodomain-Containing Protein 4: The Epigenetic Origin of Pulmonary Arterial Hypertension.26224795
Primary malignant neoplasmEpigenetic AlterationsIn cancer, increased expression of the epigenetic reader bromodomain-containing protein 4 (BRD4) sustains cell survival and proliferation.26224795
Secondary malignant neoplasm of prostateEpigenetic AlterationsThe roles of dysregulated microRNAs in prostate cancer metastasis are still unknown.26227059
Rheumatoid Arthritis, Right armEpigenetic AlterationsWe hypothesized that anti-citrullinated protein antibodies (ACPAs) could affect the expression of miRNAs in monocytes and contribute to the inflammatory responses in rheumatoid arthritis (RA).26227320
acetyl 4-aminosalicylic acidEpigenetic AlterationsTen miRNAs exhibited differential expression in U937 cells after co-cultured with ACPAs compared with human IgG.26227320
DICER1 protein, human, Non-Small Cell Lung CarcinomaEpigenetic AlterationsExpression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas.26227789
Malignant Neoplasms, Carcinoma of lungEpigenetic AlterationsAltered microRNA expression has been found to be a common feature of several cancers, including lung carcinomas.26227789
DICER1 protein, humanEpigenetic AlterationsThe biogenesis and maturation of microRNAs is known to be mediated by the ribonucleases Drosha, Dicer and Ago2.26227789
Myeloid Leukemia, Chronic, NeoplasmsEpigenetic AlterationsMicroRNA-320a acts as a tumor suppressor by targeting BCR/ABL oncogene in chronic myeloid leukemia.26228085
Malignant Neoplasms, Myeloid Leukemia, Chronic, Metastasis, NeoplasmsEpigenetic AlterationsAccumulating evidences demonstrated that the induction of epithelial-mesenchymal transition (EMT) and aberrant expression of microRNAs (miRNAs) are associated with tumorigenesis, tumor progression, metastasis and relapse in cancers, including chronic myeloid leukemia (CML).26228085
SF3B1 wt AlleleEpigenetic AlterationsThe combination of genetic and epigenetic markers was used in much more patients with MDS (62.5% [35/56]) than the use of genetic markers only (51.79% [29/56]).26228212
Glioblastoma Multiforme PathwayEpigenetic AlterationsDownregulation of serum microRNA-205 as a potential diagnostic and prognostic biomarker for human glioma.26230475
Primary malignant neoplasmEpigenetic AlterationsOBJECT Circulating microRNAs (miRNAs) are a new class of highly promising cancer biomarkers.26230475
Crohn DiseaseEpigenetic AlterationsCirculating microRNAs as biomarkers of adult Crohns disease.26230660
Hollings Cancer CenterEpigenetic AlterationsA miRNA integrated-signature of 5 upregulated and 8 downregulated miRNAs was identified from 26 published datesets in HCC using robust rank aggregation method.26231037
Hollings Cancer CenterEpigenetic AlterationsA miRNA based score using LASSO regression model provided a high accuracy for identifying HCC tissue (AUC = 0.982): HCC risk score = 0.180E_miR-221 + 0.0262E_miR-21 - 0.007E_miR-223 - 0.185E_miR-130a.26231037
Colonic NeoplasmsEpigenetic AlterationsMoreover, we further validated the confirmed miRNAs in a clinical setting using qRT-PCR and Tumor Cancer Genome Atlas (TCGA) dataset.26231037
NeoplasmsEpigenetic AlterationsFurthermore, expression of 5 miRNAs (miR-222, miR-221, miR-21 miR-214 and miR-130a) correlated with pathological tumor grade.26231037
Precursor T-cell lymphoblastic lymphomaEpigenetic AlterationsUpregulation of miRNA-17 and miRNA-19 is associated with unfavorable prognosis in patients with T-cell lymphoblastic lymphoma.26231295
Osteoarthritis, KneeEpigenetic AlterationsAltered microRNA expression profile in synovial fluid from patients with knee osteoarthritis with treatment of hyaluronic acid.26232909
Degenerative polyarthritisEpigenetic AlterationsFurther bioinformatics prediction by mirPath indicated that the differential miRNA signatures in synovial fluid extracted from the OA patients demonstrated primarily upregulation of the PI3K-Akt signaling pathway, mitogen-activated protein kinase signaling pathway, regulation of autophagy, mRNA surveillance pathway, and B cell receptor signaling pathway.26232909
Degenerative polyarthritisEpigenetic AlterationsForty-three miRNAs (21 overexpressed miRNAs and 22 underexpressed miRNAs) were differentially expressed in OA patients before and after treatment with HA (P < 0.05, false discovery rate corrected).26232909
Degenerative polyarthritisEpigenetic AlterationsOur results demonstrated that dysregulation in miRNAs in synovial fluid from OA patients and their affected biologic cellular processes might play important role in OA pathogenesis and HA-mediated therapeutics.26232909
Stomach CarcinomaEpigenetic AlterationsCirculating microRNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer.26233325
MetastasisEpigenetic AlterationsBased on the preliminary experiments, miR-203 was selected as the candidate serum miRNA that was most closely associated with metastasis.26233325
MetastasisEpigenetic AlterationsMicroRNAs (miRNAs) relating to the epithelial-mesenchymal transition (EMT) control GC progression and metastasis.26233325
Carcinoma of lungEpigenetic AlterationsTo find the association of two pre-miRNA polymorphisms with risk of lung cancer in North Indians.26235181
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-486 as a Biomarker for Early Diagnosis and Recurrence of Non-Small Cell Lung Cancer.26237047
Carcinoma of lungEpigenetic AlterationsMiRNA (miR)-486 and miR-150 were found to significantly distinguish lung cancer patients from healthy volunteers.26237047
Primary malignant neoplasm, Non-Small Cell Lung CarcinomaEpigenetic AlterationsAltered expressions in many cancer types including NSCLC and stable existence in plasma make microRNAs (miRNAs) a group of potentially useful biomarkers for clinical assessments of patients with NSCLC.26237047
NeoplasmsEpigenetic AlterationsExpression of ten miRNAs in the plasma and tumor sections of the patients was detected by quantitative real-time polymerase chain reaction.26237047
methionine, Stomach Carcinoma, MetastasisEpigenetic AlterationsMicroRNA-34a attenuates the proliferation, invasion and metastasis of gastric cancer cells via downregulation of MET.26238271
Stomach CarcinomaEpigenetic AlterationsAs a direct target of p53, the functions of microRNA (miR)-34a are important, but controversial, in the progression of gastric cancer.26238271
Dental PlaqueEpigenetic AlterationsMicroRNA deregulation in symptomatic carotid plaque.26238333
Medical Device Material Rupture, Plaque (lesion)Epigenetic AlterationsGenetic mechanisms and especially the roles played by microRNAs in the regulation of plaque destabilization and rupture are mostly unknown.26238333
atheroscleroticEpigenetic AlterationsAfter isolation of total RNA from atherosclerotic plaques, microRNAs were quantified by real-time polymerase chain reaction.26238333
Weight decreased, Cerebrovascular accidentEpigenetic AlterationsEpigenetic Changes in the Methylation Patterns of KCNQ1 and WT1 after a Weight Loss Intervention Program in Obese Stroke Patients.26238466
Cerebrovascular accident, Obesity, InflammationEpigenetic AlterationsEpigenetic mechanisms could be involved in obesity, inflammation and stroke.26238466
Carcinoma of lungEpigenetic AlterationsA miRNA microarray was used to profile miRNAs of lung cancer tissues.26238736
Primary malignant neoplasmEpigenetic AlterationsThus, the results are of importance for clinical investigators and for those who design miRNA-based novel cancer therapeutics.26238736
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIt was identified that 33 miRNAs with >2.0-fold change and FDR <0.05 were differentially expressed between the adjacent non-cancerous lung tissues and non-small cell lung cancers NSCLCs (P<0.005).26238736
Carcinoma of lung, Non-Small Cell Lung CarcinomaEpigenetic AlterationsValidation of significant miRNAs in independent 40 paired NSCLC tissues demonstrated that the expression level of miR-486-5p and miR-30a-5p was significantly downregulated in another 40 paired lung cancer tissues.26238736
Non-Small Cell Lung CarcinomaEpigenetic AlterationsTaken together, the results provided strong evidence of the possible involvement of miRNAs in the development and progression of NSCLC.26238736
MeningiomaEpigenetic AlterationsEpigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma.26240495
Diabetic RetinopathyEpigenetic AlterationsEpigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy.26241401
MeningiomaEpigenetic AlterationsExpression of Stem Cell Marker Nestin and MicroRNA-21 in Meningiomas.26242334
Degenerative polyarthritisEpigenetic AlterationsSignature of microRNA expression during osteogenic differentiation of bone marrow MSCs reveals a putative role of miR-335-5p in osteoarthritis.26243143
Degenerative polyarthritisEpigenetic AlterationsWe describe the existence of a correlation between miR-335-5p expression and OA indicating the putative role of this miRNA in OA features.26243143
Squamous cell carcinoma of esophagusEpigenetic AlterationsExpression and role of oncogenic miRNA-224 in esophageal squamous cell carcinoma.26245343
cervical cancerEpigenetic AlterationsThese studies support the concept that epigenetic changes regulate expression of Keap1 in cervical cancer tissues.26247201
Tumor necrosis, Periodontitis, Rheumatoid Arthritis, Right arm, TNF protein, humanEpigenetic AlterationsOver-expression of tumor necrosis factor-alpha (TNF-a) plays a pathological role in chronic periodontitis (CP) and rheumatoid arthritis (RA), which might be regulated by the epigenetic mechanism.26247485
Prostate Cancer PathwayEpigenetic AlterationsHigh-Level Expression of microRNA-21 in Peripheral Blood Mononuclear Cells Is a Diagnostic and Prognostic Marker in Prostate Cancer.26247873
NeoplasmsEpigenetic AlterationsProtein arginine methyltransferase-5 (PRMT5), a major type II arginine methyltransferase, is an important epigenetic modifier with oncogene-like properties because of its ability to repress the expression of tumor suppressor genes.26248553
Hollings Cancer CenterEpigenetic AlterationsMicroRNA-148a may act as a suppressor miRNA of HCC, and it is therefore a potential prognostic biomarker for HCC patients.26248880
Prostate Cancer PathwayEpigenetic AlterationsOur study suggests that elevated Alu blood DNA methylation levels several years before diagnosis may be associated with an increased prostate cancer risk.26250474
Primary central nervous system lymphomaEpigenetic AlterationsWe have previously demonstrated differential expression of microRNAs in cerebrospinal fluid (CSF) samples from patients with PCNSL.26250566
Adenocarcinoma of large intestineEpigenetic AlterationsSerum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma.26250939
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsWe sought to identify a serum miRNA expression profile to improve disease surveillance and to predict post-operative disease recurrence for stage II/III colorectal cancer (CRC) patients.26250939
Clinical CoordinatorEpigenetic AlterationsThe area under the ROC curve (AUC) for the three-miRNA panel was 0.886 (95% CI 0.850-0.921) for discriminating between pre-operative CRC patients and normal subjects and 0.850 (95% CI 0.809-0.891) for discriminating between pre- and post-operative CRC patients.26250939
Subarachnoid Hemorrhage, AneurysmalEpigenetic AlterationsGene expression and DNA methylation changes in aneurysmal subarachnoid hemorrhage patients undergoing RIC are involved in coordinated cell cycle and inflammatory responses.26251247
NeoplasmsEpigenetic AlterationsmiRNAs can either function as tumor suppressor genes or oncogenes in various important pathways.26251897
NeoplasmsEpigenetic AlterationsThe expression of specific miRNAs has been identified to correlate with tumor prognosis.26251897
Diffuse Large B-Cell LymphomaEpigenetic AlterationsSeven miRNAs (miR-16_1*, miR-16_2*, miR-27a, miR-103, miR-185, miR-199, and miR-497) were statistically significantly up-regulated in DLBCL compared to normal germinal cells.26251897
Liver carcinomaEpigenetic AlterationsMicroRNA-122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma.26252254
Breast Cancer Cell, NeoplasmsEpigenetic AlterationsMicroRNA-122 (miR-122) is considered as a tumor suppressor in human cancer.26252254
Hollings Cancer CenterEpigenetic AlterationsMicroRNAs (miRNAs) have been implicated in HCC progression.26252254
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-132 (miR-132) has been reported to play a tumor suppressive role in different human malignancies.26252738
Breast Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-338-3p functions as tumor suppressor in breast cancer by targeting SOX4.26252944
ovarian neoplasm, Neoplasms, Carcinoma of lung, Colorectal Carcinoma, Stomach CarcinomaEpigenetic AlterationsMicroRNA-338-3p (miR-338-3p), a recently discovered miRNA, has been reported to be downregulated and play tumor suppressor roles in gastric cancer, ovarian cancer, colorectal carcinoma and lung cancer by targeting several genes.26252944
Primary malignant neoplasmEpigenetic AlterationsDNA methylation at the 5 position of cytosine (5 mC) is an epigenetic hallmark in cancer.26253945
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is a common epigenetic change in cancer.26254350
Squamous cell carcinoma of esophagusEpigenetic AlterationsHowever, microRNA (miRNA) regulation by epigenetic alteration, especially CpG island hypermethylation, remains poorly understood in esophageal squamous cell carcinoma (ESCC).26254350
Squamous cell carcinoma of esophagusEpigenetic AlterationsSuppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinoma.26254350
Primary malignant neoplasmEpigenetic AlterationsThe miRNA-145 promoter was significantly more hypermethylated in the cancer tissues than in matched normal adjacent esophageal epithelial mucosa (p=0.0042; paired t-test).26254350
Squamous cell carcinoma of esophagusEpigenetic AlterationsmiRNA-145 expression in ESCC seems to be regulated by hypermethylation of the miRNA-145 promoter region.26254350
Breast CarcinomaEpigenetic AlterationsEpigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer.26258411
Breast CarcinomaEpigenetic AlterationsTogether, our results show that epigenetic silencing of ITGA2 by miR-373 stimulates breast cancer migration, and miR-373high/ITGA2low may be as a prognosis biomarker for breast cancer patients.26258411
Alzheimers DiseaseEpigenetic AlterationsThese results suggest that a basic defect in Alzheimer disease may be the reduced microRNA-driven increased expression of proteins that may alter the apoptotic/antiapoptotic balance of neurons.26258756
Secondary malignant neoplasm of liverEpigenetic AlterationsTaken together, our results demonstrate thatmiR-99b-5p is differently expressed in primary CRC and liver metastasis and functions as a tumor-suppressive microRNA in metastatic CRC.26259252
Secondary malignant neoplasm of liver, Colorectal Cancer PathwayEpigenetic AlterationsmiRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR.26259252
Secondary malignant neoplasm of liver, Clinical CoordinatorEpigenetic AlterationsIn this study we screened the different expression profiles of microRNAs (miRNAs) on the development of liver metastasis in CRC patients.26259252
Clinical Coordinator, Ulcerative ColitisEpigenetic AlterationsKey gene expressions of the histone modification enzyme were assessed and compared in CRC, UC and control groups using the RT-PCR array technique.26259750
Clinical Coordinator, CarcinogenesisEpigenetic AlterationsHistone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC.26259750
ovarian neoplasmEpigenetic AlterationsMicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancer.26260454
Carcinoma, Ovarian EpithelialEpigenetic AlterationsSerous epithelial ovarian cancer (SEOC) is a highly metastatic disease and its progression has been implicated with microRNAs.26260454
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs have become recognized as key players in the development of malignancy.26261507
NeoplasmsEpigenetic AlterationsTogether, our data provide a novel epigenetic mechanism regulating tumor cell invasion and EMT, and provide a biomolecule for ccRCC diagnosis and prognosis.26261509
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsCirculating microRNAs (miRNAs) were recognized to be potential non-invasive biomarkers for colorectal cancer (CRC) detection and prediction.26261602
Colorectal Cancer PathwayEpigenetic AlterationsThe potential of plasma miRNAs for diagnosis and risk estimation of colorectal cancer.26261602
Clinical CoordinatorEpigenetic AlterationsMeanwhile, the association of the expression of plasma miRNAs with the risk of CRC patients has rarely been analyzed.26261602
Clinical CoordinatorEpigenetic AlterationsSensitivity and specificity were employed to evaluate the diagnostic value of miRNAs for CRC.26261602
Clinical CoordinatorEpigenetic AlterationsUnivariate and multivariate logistic regression were employed to analyze the association between miRNAs expression and CRC risk.26261602
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsHox transcript antisense intergenic RNA (HOTAIR) is a long non-coding RNA, its overexpression has been documented in various human solid tumor and it can be considered as a potential cancer biomarker.26261618
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsmiRNA-21 and miRNA-34a Are Potential Minimally Invasive Biomarkers for the Diagnosis of Pancreatic Ductal Adenocarcinoma.26262588
Malignant Pleural MesotheliomaEpigenetic AlterationsTwo Different Serum MiRNA Signatures Correlate with the Clinical Outcome and Histological Subtype in Pleural Malignant Mesothelioma Patients.26262875
Hollings Cancer CenterEpigenetic AlterationsMiR-193a-3p may be a tumor-suppressive miRNA which is down-regulated in HCC tissues.26263159
Hepatitis B, Liver carcinomaEpigenetic AlterationsCirculating microRNAs as biomarkers for diagnosis of early hepatocellular carcinoma associated with hepatitis B virus.26264553
Primary malignant neoplasmEpigenetic AlterationsLongitudinal Study of DNA Methylation of Inflammatory Genes and Cancer Risk.26265203
Primary malignant neoplasmEpigenetic AlterationsDNA methylation modification, one of the epigenetic mechanisms regulating gene expression, is considered a hallmark of cancer.26265203
Neoplasms, Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway.26265437
NeoplasmsEpigenetic AlterationsThe overexpression of miRNA-1908 significantly promoted anchorage-independent growth in vitro and significantly increased the tumor forming potential in vivo.26265437
Glioblastoma MultiformeEpigenetic AlterationsmiRNA-1908 functions as an oncogene in glioblastoma by repressing the PTEN pathway.26265437
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer.26266366
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsThe expression of abnormal microRNA (miRNA, miR) is a ubiquitous feature of colorectal cancer (CRC).26266366
Primary malignant neoplasmEpigenetic AlterationsDifferential miRNA rather than snoRNA expression was robust enough to distinguish synchronous cancer from normal mucosa.26266366
Clinical CoordinatorEpigenetic AlterationsFunction analysis of putative targets suggested that miRNA clusters may modulate multiple effectors of oncogenic pathways involved in the pathogenesis of synchronous CRC.26266366
Clinical CoordinatorEpigenetic AlterationsAberrant miRNA expression profiles could potentially be used as a diagnostic tool for synchronous CRC.26266366
Clinical CoordinatorEpigenetic AlterationsOur findings represent the first comprehensive miRNA and snoRNA expression signatures for synchronous CRC, implicating that the miRNAs and snoRNAs may present therapeutic targets for synchronous CRC.26266366
Clinical CoordinatorEpigenetic AlterationsWe found a global dysregulation of miRNAs, including an oncogenic miR-17-92 cluster and oncosuppressive miR-143-145 cluster, and snoRNAs in synchronous CRC.26266366
NeoplasmsEpigenetic AlterationsThe target genes of miRNA identified in this study played important roles in tumor signaling pathways, and their detailed functions could be further studied so as to explore novel neuroglioma therapies.26269115
Endothelial dysfunctionEpigenetic AlterationsPlasma miRNAs may be useful as potential screening tools for the presence of endothelial dysfunction in children and may reveal endothelial dysfunction-relevant target genes.26270249
Breast CarcinomaEpigenetic AlterationsOur results reflect an epigenetic regulation of Rbl2/p130 expression in breast cancer.26271034
LymphomaEpigenetic AlterationsDeregulation of miRNA-16 and miRNA-155 was limited to lymphoma patients.26272105
Small cell carcinoma of lungEpigenetic AlterationsOur data illuminate that the MDM4rs4245739SNP contributes to SCLC risk and support the notion that gene 3-UTR genetic variants, impacting miRNA-binding, might modify SCLC susceptibility.26274820
Small cell carcinoma of lungEpigenetic AlterationsA Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer.26274820
Admitting diagnosisEpigenetic AlterationsDNA methylation is altered in AD patients, suggesting that epigenetic mechanisms play a role in AD pathophysiology.26275347
Breast CarcinomaEpigenetic AlterationsHsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1.26275461
Breast Carcinoma, NeoplasmsEpigenetic AlterationsOur findings emphasized the potential role of miR-1 as tumor suppressive miRNA in breast cancer.26275461
Renal Cell CarcinomaEpigenetic AlterationsDownregulated ECRG4 is associated with poor prognosis in renal cell cancer and is regulated by promoter DNA methylation.26276361
Breast CarcinomaEpigenetic AlterationsCirculating miRNAs revealed as surrogate molecular signatures for the early detection of breast cancer.26276721
Breast CarcinomaEpigenetic AlterationsResults showed differential pattern of expressions of these miRNAs in multiple cohorts, however in early stage breast cancer, miR-106a-5p and miR-454-3p were upregulated (p < 0.05), miR-195-5p and miR-495 were downregulated (p < 0.05) in PBMCs.26276721
Primary malignant neoplasmEpigenetic AlterationsIn addition, these miRNAs were also significantly associated with cancer and ErbB signaling pathways.26276721
Carcinogenesis, Primary malignant neoplasm, Esophageal carcinomaEpigenetic AlterationsMicroRNAs (miRNAs) have a key role in carcinogenesis and cancer development, but the role of miRNAs in the progression of esophageal cancer (EC) remains unclear.26279431
Prostate Cancer PathwayEpigenetic AlterationsTranscriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer.26282172
Prostate Cancer PathwayEpigenetic AlterationsHere, we report the identification of 145 previously unannotated intergenic long noncoding RNA transcripts (lncRNA) or isoforms that are associated with prostate cancer or CRPC.26282172
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsExosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients.26284486
Depression, CTCAEEpigenetic AlterationsThe regulation of the brain-derived neurotrophic factor (BDNF) is important for depression pathophysiology and epigenetic regulation of the BDNF gene may be involved.26285129
Acute Promyelocytic LeukemiaEpigenetic AlterationsMutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide.26285909
Adenocarcinoma of lung (disorder)Epigenetic AlterationsA novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27.26291312
Malignant NeoplasmsEpigenetic AlterationsLong noncoding RNAs (lncRNAs) are known to regulate the development and progression of various cancers.26291312
Adenoid Cystic CarcinomaEpigenetic AlterationsExpression of miRNAs in adenoid cystic carcinomas of the breast and salivary glands.26293217
HyperhomocysteinemiaEpigenetic AlterationsSuboptimal B vitamins status and hyperhomocysteinemia are associated with altered DNA methylation and telomere length.26293976
ovarian neoplasmEpigenetic AlterationsCompared with scramble miRNA overexpression of miR-24 was validated to remarkably induce ovarian cancer cells apoptosis.26296081
DiseaseEpigenetic AlterationsSubstantial evidence has shown that microRNAs (miRNAs) may be causally linked to the occurrence and progression of human diseases.26296081
DiseaseEpigenetic AlterationsNinety-nine miRNAs were scanned for possible functional association with 2223 MeSH-defined human diseases.26296081
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, AcuteEpigenetic AlterationsCC-486 (oral azacitidine) is an epigenetic modifier in development for patients with myelodysplastic syndromes and acute myeloid leukemia.26296092
HypoxiaEpigenetic AlterationsRRx-001 is activated by hypoxia and induces the generation of reactive oxygen and nitrogen species that can epigenetically modulate DNA methylation, histone deacetylation, and lysine demethylation.26296952
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsEpigenetic alterations have been strongly associated with tumour formation and resistance to chemotherapeutic drugs, and epigenetic modifications are an attractive target in cancer research.26296952
Malignant NeoplasmsEpigenetic AlterationsHypomethylating agents are used to treat cancers driven by aberrant DNA methylation, but their short half-life might limit their activity, particularly in patients with less proliferative diseases.26296954
Secondary malignant neoplasm of lung, Primary malignant neoplasmEpigenetic AlterationsPulmonary Metastases Exhibit Epigenetic Clonality: Implications for Precision Cancer Therapy.26298164
Secondary malignant neoplasm of lungEpigenetic AlterationsPulmonary metastases exhibit patient-specific epigenetic clonality, which may be exploited for precision therapies targeting aberrant CT or TS gene expression.26298164
Secondary malignant neoplasm of lungEpigenetic AlterationsPRC-2 may be a shared target for epigenetic therapy of pulmonary metastases.26298164
MetastasisEpigenetic AlterationsAlthough epithelial-to-mesenchymal transition (EMT), TNF-a and microRNA (miRNA) have been found to play important roles in lymph node metastasis, the underlying molecular mechanism remains unclear.26302825
Clinical Coordinator, Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsHere we reported that high expression of microRNA-19a (miR-19a) was associated with lymph node metastasis and played an important role in TNF-a-induced EMT in colorectal cancer (CRC) cells.26302825
Aortic Valve StenosisEpigenetic AlterationsCirculating microRNA Profiling Needs Further Refinement Before Clinical Use in Patients With Aortic Stenosis.26304936
Aortic Valve StenosisEpigenetic AlterationsDespite holding great promise, circulating miRNA profiling requires further refinement before translation into clinical use as a biomarker in aortic stenosis.26304936
Non-Small Cell Lung CarcinomaEpigenetic AlterationsEpigenetic downregulated ITGBL1 promotes non-small cell lung cancer cell invasion through Wnt/PCP signaling.26307393
ovarian neoplasm, NeoplasmsEpigenetic AlterationsFrom this dataset, we selected 21 archetypical coding genes and one noncoding RNA, based on statistically significant differences in their expression profile between tumors, for validation by qPCR in a larger cohort of 110 ovarian tumors (71 primary and 39 recurrent) and for testing association of specific genes with time-to-recurrence (TTR).26311224
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMolecular tests based on microRNA expression allow a reliable classification of subtypes for NSCLC and can constitute a useful diagnostic strategy in patient selection for targeted therapy.26311306
ASAH1 protein, human, Adenocarcinoma of lung (disorder), Squamous cell carcinoma of lungEpigenetic AlterationsMicroRNAs constitute a promising class of biomarkers and a helpful tool for the distinction between lung adenocarcinoma (AC) and squamous cell lung carcinoma (SCC).26311306
Stomach CarcinomaEpigenetic AlterationsMicroRNA-10b promotes migration and invasion through Hoxd10 in human gastric cancer.26311318
CO-methylating acetyl-CoA synthase activity, Depression, CTCAEEpigenetic AlterationsAdequate antidepressants treatment may effective particularly in those with higher BDNF methylation and then can overcome epigenetic vulnerability for depression persistence in ACS patients.26313133
Chronic diseaseEpigenetic AlterationsAbout a tenth of miRNAs plausibly related to chronic disease were reliably detected in stored samples of healthy adults.26313271
Pancreatic Intraductal Papillary-Mucinous AdenomaEpigenetic AlterationsPlasma MicroRNAs as Novel Biomarkers for Patients with Intraductal Papillary Mucinous Neoplasms of the Pancreas.26314797
Malignant NeoplasmsEpigenetic AlterationsData support the importance of miRNAs in the progression of IPMNs to malignancy, and we hypothesized that miRNAs may be shed from IPMN tissues and detected in blood.26314797
Carcinoma of lungEpigenetic AlterationsMicroRNA-200 promotes lung cancer cell growth through FOG2-independent AKT activation.26314828
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-200 (miR-200) has emerged as a regulator of the PI3K/AKT pathway and cancer cell growth.26314828
Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have recently been identified to be involved in various diseases including cancer.26314847
Liver carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma.26315541
Hollings Cancer CenterEpigenetic AlterationsBy comparing the expression profiles of miRNAs in different subtypes of HCC, we identified miR-424 as a HCC related miRNA.26315541
Squamous cell carcinoma, NeoplasmsEpigenetic AlterationsmiRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3b in oral squamous cell carcinoma Tca-8113 cells.26315788
Squamous cell carcinoma, Carcinogenesis, SERPINB3 wt AlleleEpigenetic AlterationsDysregulation of microRNAs (miRNAs) has been associated with carcinogenesis in oral squamous cell carcinoma (OSCC).26315788
Malignant Neoplasms, Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsThe receptor for advanced-glycation end products (RAGE) is upregulated in various cancers and has been associated with tumor progression, but little is known about its expression and regulation by microRNAs (miRNAs) in esophageal squamous cell carcinoma (ESCC).26316588
SF3B1 wt AlleleEpigenetic AlterationsOur findings show that the Shh signaling pathway plays a role in the pathogenesis and disease progression of MDS, and proceeds by modulating DNA methylation.26317501
palladiumEpigenetic AlterationsTogether, these data strengthen the connection between saturated fatty acids, neuroflammation, ER stress, epigenetic alteration and bioenergetic compromise in PD.26317511
AstrocytomaEpigenetic AlterationsRecent studies have shown that astrocytoma formation is the result of the deregulation of several pathways, including the RB/E2F pathway, which is commonly deregulated in various human cancers via genetic or epigenetic mechanisms.26317630
Malignant NeoplasmsEpigenetic AlterationsPanobinostat is a radiosensitizing agent and targets the epigenetics of malignancy.26317683
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-215 (miR-215) promotes tumor growth in various human malignancies.26317904
Malignant neoplasm of urinary bladderEpigenetic AlterationsDouble-negative feedback loop between long non-coding RNA TUG1 and miR-145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells.26318860
Glioblastoma MultiformeEpigenetic AlterationsA five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients.26320189
NeoplasmsEpigenetic AlterationsDNA methylation occurs in the displacement loop (D-loop) region of mammals; however, D-loop regions of certain tumor tissue types were found to be de-methylated.26323487
Primary malignant neoplasmEpigenetic AlterationsThe involvement of circulating microRNAs (miRNAs) in cancer and their potential as diagnostic and prognostic biomarkers are becoming increasingly known.26323574
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-498 is downregulated in non-small cell lung cancer and correlates with tumor progression.26323905
Carcinoma of lung, Malignant Neoplasms, Non-Small Cell Lung CarcinomaEpigenetic AlterationsNon-small cell lung cancer (NSCLC) is the most common type of human lung cancer, with highly aggressive, lethal malignancy and microRNAs have already been proven to be associated with NSCLC tumorigenesis.26323905
Malignant tumor of colonEpigenetic AlterationsThe microRNA (miRNA), miR-34a is significant in colon cancer progression.26324236
Primary malignant neoplasmEpigenetic AlterationsWe originally established Spearman correlation transition model to quantify the cooperativity disorientation associated with the transition from normal to precancerous to cancer tissue, in conjunction with miRNA-mRNA regulatory network and machine learning algorithm to identify genes with prognostic value.26325386
Malignant neoplasm of urinary bladder, HematuriaEpigenetic AlterationsEvaluation of an Epigenetic Profile for the Detection of Bladder Cancer in Patients with Hematuria.26327355
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-33b inhibits tumor cell growth and is associated with prognosis in colorectal cancer patients.26329295
AMD1 wt Allele, Chronic Kidney DiseasesEpigenetic AlterationsOcular fundus pathology in patients with BN is similar to the pathology of other CKD, but with significantly more AMD (about four times), probably related to the genetic/epigenetic factors.26329737
Rheumatoid ArthritisEpigenetic AlterationsAssessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate.26330155
Rheumatoid Arthritis, Right armEpigenetic AlterationsDNA methylation is an epigenetic mechanism regulating gene expression that has been insufficiently studied in the blood of rheumatoid arthritis (RA) patients, as only T cells and total peripheral blood mononuclear cells (PBMCs) from patients with established RA have been studied and with conflicting results.26330155
Secondary malignant neoplasm of female breast, Breast CarcinomaEpigenetic AlterationsRecent investigations have demonstrated the importance of some miRNA in breast cancer, but the significance of the great majority of miRNA remains largely unclear in breast cancer metastasis.26331797
Primary NeoplasmEpigenetic AlterationsDNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence.26332453
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsAltered DNA methylation in CpG islands of gene promoters has been implicated in prostate cancer (PCa) progression and can be used to predict disease outcome.26332453
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsIn silico analysis of The Cancer Genome Atlas data confirmed increased DNA methylation of two loci-SRD5A2 and CYP11A1, which also correlated with their decreased expression, in tumors with subsequent BCR development.26332453
Retinitis PigmentosaEpigenetic AlterationsOverall, increased DNA methylation of SRD5A2 and CYP11A1 related to androgen biosynthesis functions may play a role in BCR after patients RP.26332453
NeoplasmsEpigenetic AlterationsInappropriate DNA methylation is frequently associated with human tumour development, and in specific cases, is associated with clinical outcomes.26332997
Malignant neoplasm of urinary bladderEpigenetic AlterationsPrevious reports of DNA methylation in low/intermediate grade non-muscle invasive bladder cancer (NMIBC) have suggested that specific patterns of DNA methylation may have a role as diagnostic or prognostic biomarkers.26332997
Stomach CarcinomaEpigenetic AlterationsGenetic and epigenetic alterations play an important role in gastric cancer (GC) pathogenesis.26334097
Stomach CarcinomaEpigenetic AlterationsDeregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer.26334097
NeoplasmsEpigenetic AlterationsWe compared mRNA and miRNA expression levels among 66 gastric tumor and normal adjacent mucosa samples using quantitative real-time reverse transcription PCR.26334097
Colorectal CarcinomaEpigenetic AlterationsOur aim was to identify DNA methylation changes associated with the growth pattern and invasiveness of colorectal cancers (CRCs).26334593
Colorectal NeoplasmsEpigenetic AlterationsEpigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.26334593
Stomach CarcinomaEpigenetic AlterationsUpregulated expression of long non-coding RNA LINC00982 regulates cell proliferation and its clinical relevance in patients with gastric cancer.26334618
Primary malignant neoplasmEpigenetic AlterationsEmerging evidences indicate that dysregulated long non-coding RNAs (lncRNAs) are implicated in cancer tumorigenesis and progression and might be used as diagnosis and prognosis biomarker or potential therapeutic targets.26334618
Primary malignant neoplasmEpigenetic AlterationsPotential of DNA methylation in rectal cancer as diagnostic and prognostic biomarkers.26335606
Colorectal CarcinomaEpigenetic AlterationsAberrant DNA methylation is more prominent in proximal compared with distal colorectal cancers.26335606
NeoplasmsEpigenetic AlterationsDNA methylation differences were assessed by a targeted DNA microarray for 360 marker candidates between 22 fresh frozen rectal tumour samples and 8 controls and validated by microfluidic high-throughput and methylation-sensitive qPCR in fresh frozen and formalin-fixed paraffin-embedded (FFPE) samples, respectively.26335606
NeoplasmsEpigenetic AlterationsGene expression profiles and microRNAs allow prognostically unfavorable tumors of the mesenchymal subtype to be distinguished.26335822
Liver carcinomaEpigenetic AlterationsLong non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2.26336870
Malignant Neoplasms, Hollings Cancer CenterEpigenetic AlterationsRecent evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including HCC.26336870
Cervical Intraepithelial NeoplasiaEpigenetic AlterationsWhile there is no ideal biomarker for making an early diagnosis of CIN, we hypothesized that levels of specific circulating microRNA (miRNA) species might serve such a role.26337190
Kidney Failure, AcuteEpigenetic AlterationsDysregulated microRNAs involved in contrast-induced acute kidney injury in rat and human.26337190
Cervical Intraepithelial NeoplasiaEpigenetic AlterationsAmong the 17 miRNAs aberrantly-expressed miRNAs screened from kidney tissue, only six also showed significantly different expression in the plasma of CIN rats.26337190
Cervical Intraepithelial NeoplasiaEpigenetic AlterationsOur study provides the first evidence that plasma miRNAs, and especially three miR-30 family members (miR-30a, miR-30c, and miR-30e), might serve as early biomarkers and (or) target candidates for CIN.26337190
Non-Small Cell Lung CarcinomaEpigenetic AlterationsSerum microRNA-365 in combination with its target gene TTF-1 as a non-invasive prognostic marker for non-small cell lung cancer.26337230
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA (miR)-365 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) cells by targeting thyroid transcription factor 1 (TTF-1).26337230
Chronic sinusitisEpigenetic AlterationsMicroRNA expression profile of mature dendritic cell in chronic rhinosinusitis.26337346
CraniosynostosisEpigenetic AlterationsBy comparing miRNA gene expression patterns in 3 types of CRS patients, we have been able to identify candidate miRNAs that might mediate the core pathogenesis of CRS through regulating dendritic cells.26337346
CraniosynostosisEpigenetic AlterationsThese miRNAs could serve as potential therapeutic targets for CRS.26337346
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsmiR9 is an important tumor suppressor microRNA regulated by DNA methylation in various types of cancers.26337487
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsCirculating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction.26337652
Inflammation, Fibrosis AssessmentEpigenetic AlterationsMicroRNA (miR)-146a and miR-21 have been reported to participate in inflammatory reactions and fibrosis.Excessive inflammation and cardiac fibrosis may play important roles in the development of left ventricular remodeling(LVR).26337652
SepticemiaEpigenetic AlterationsClinical evaluation of circulating microRNA-25 level change in sepsis and its potential relationship with oxidative stress.26339334
SepticemiaEpigenetic AlterationsMeanwhile, microRNA-25 level may be associated with oxidative stress in patients with sepsis, and it is expected to become a target for anti-oxidation therapy.26339334
Prostate Cancer PathwayEpigenetic AlterationsPrognostic implications of tissue and serum levels of microRNA-128 in human prostate cancer.26339409
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsMicroRNA-128 (miR-128) has been identified as a negative regulator of malignant phenotypes of prostate cancer (PCa) cells.26339409
Carcinoma of lungEpigenetic AlterationsThe miRNA-448 and 4478 were significantly overexpressed in lung cancer patients compared to healthy people and these two molecules were qualified for further analysis.26341493
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsAberrant expression of microRNAs (miRNAs) in cancer patients compared to healthy people as well as possibility of detection of these molecules in blood samples make them potential biomarkers of various cancers.26341493
Carcinoma of lungEpigenetic AlterationsUsing quantitative reverse transcription polymerase chain reaction (qRT-PCR) technique, we assessed expression of studied miRNAs in plasma samples of 90 lung cancer patients and 85 healthy individuals.26341493
Carcinoma of lungEpigenetic AlterationsOur results suggest that the examination of miRNAs could be considered as potential lung cancer, non-invasive biomarkers.26341493
ovarian neoplasmEpigenetic AlterationsOverexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/b-catenin pathway in human ovarian cancer.26341496
Cardiovascular DiseasesEpigenetic AlterationsThere is increasing evidence that microRNAs (miRNAs) are deregulated in autoimmune and cardiovascular diseases.26342092
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-21 Expression in Primary Breast Cancer Tissue Among Egyptian Female Patients and its Correlation with Chromosome 17 Aneusomy.26342497
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-21 (miR-21), on chromosome 17q21.3, is one of the most up-regulated microRNAs in cancer that silences multiple target genes involved in cancer-signaling pathways.26342497
Rhabdoid Tumor, Aggressive malignanciesEpigenetic AlterationsRhabdoid tumors are aggressive malignancies that show loss-of-function mutations of SMARCB1 gene, a member of the SWI/SNF chromatin-remodeling complex controlling gene transcription.26342593
Myeloid Leukemia, ChronicEpigenetic AlterationsIn parallel, Polycomb group genes (PcGs) are epigenetic repressors implicated in CML progression and in therapy resistance.26343356
Primary malignant neoplasmEpigenetic AlterationsModest transcriptional changes caused by genetic or epigenetic mechanisms are frequent in human cancer.26343801
Cervix carcinoma, Rash and Dermatitis Associated with Chemoradiation, CTCAEEpigenetic AlterationsEpigenetic Alteration by DNA Methylation of ESR1, MYOD1 and hTERT Gene Promoters is Useful for Prediction of Response in Patients of Locally Advanced Invasive Cervical Carcinoma Treated by Chemoradiation.26344356
factor VIII, Chronic Obstructive Airway Disease, Chronic heart failure, Congestive heart failureEpigenetic AlterationsPlasma miRNA profiling included 137 patients with AHF from 3 different cohorts, 20 with chronic heart failure (CHF), 8 with acute exacerbation of COPD, and 41 healthy controls.26345695
factor VIIIEpigenetic AlterationsA further drop in miRNA levels within 48 h after AHF admission was associated with an increased risk of 180-day mortality in a subset of the identified miRNAs.26345695
factor VIIIEpigenetic AlterationsEarly in-hospital decreasing miRNA levels were predictive for mortality in a subset of miRNAs in patients with AHF.26345695
Acute heart failureEpigenetic AlterationsSignature of circulating microRNAs in patients with acute heart failure.26345695
factor VIII, Acute heart failureEpigenetic AlterationsOur aim was to identify circulating microRNAs (miRNAs) associated with acute heart failure (AHF).26345695
factor VIII, Congestive heart failureEpigenetic AlterationsPlasma levels of miRNAs in patients with AHF were decreased compared with CHF patients or healthy subjects, whereas no significant changes were observed between acute COPD patients and controls.26345695
factor VIIIEpigenetic AlterationsOut of these 15 miRNAs, 12 could be confirmed in an additional AHF validation cohort and 7 passed the Bonferroni correction threshold (miR-18a-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-106a-5p, miR-199a-3p, and miR-652-3p, all P < 0.00005).26345695
Heart failureEpigenetic AlterationsDeclining levels of circulating miRNAs were associated with increasing acuity of heart failure.26345695
Liver carcinomaEpigenetic AlterationsLow-level expression of microRNA-375 predicts poor prognosis in hepatocellular carcinoma.26349912
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsMicroRNAs are predicted to play fundamental roles in the tumorigenesis of hepatocellular carcinoma (HCC).26349912
Colorectal Cancer PathwayEpigenetic AlterationsEffect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer.26349991
Colorectal Cancer PathwayEpigenetic AlterationsWe therefore evaluated DNA methylation and transcript levels of two members of the OATP family, OATP3A1 and OATP4A1, that may be involved in E1-S transport in colorectal cancer patients.26349991
CarcinogenesisEpigenetic AlterationsOur results suggest a potential mechanism for OATP3A1 downregulation that involves DNA methylation during colorectal carcinogenesis.26349991
Hodgkin DiseaseEpigenetic AlterationsDNA methylation patterns in EBV-positive and EBV-negative Hodgkin lymphomas.26350502
Malignant Neoplasms, Epstein-Barr Virus InfectionsEpigenetic AlterationsAlthough epigenetic alterations, such as aberrant DNA methylation, are known to contribute to the pathogenesis of various malignancies, little is known about such alterations in HL and their putative relationships with EBV infection.26350502
Primary malignant neoplasm, ArthritisEpigenetic AlterationsMicroRNAs (miRNA), small noncoding RNA molecules, are endogenous regulators of gene expression that have been implicated in the pathogenesis of various diseases such as cancer and arthritis.26350536
Degenerative polyarthritisEpigenetic AlterationsMicroRNA-16-5p Controls Development of Osteoarthritis by Targeting SMAD3 in Chondrocytes.26350536
HepatitisEpigenetic AlterationsmiRNAs found to be upregulated in severe hepatitis were then quantified by real-time PCR in the expanded cohort of 54 patients.26352910
Blood Coagulation Disorders, Acute viral hepatitisEpigenetic AlterationsMicro RNAs mir-106a, mir-122 and mir-197 are increased in severe acute viral hepatitis with coagulopathy.26352910
Fibrosis AssessmentEpigenetic AlterationsFurther, we identify concordant histone methylation and acetylation changes in the promoter and putative novel enhancer elements of genes involved in liver fibrosis.26353929
Aplastic AnemiaEpigenetic AlterationsOur work describes previously unknown regulatory roles of microRNA in T-cell activation in aplastic anemia, which may open a new perspective for development of effective therapy.26354756
Infection caused by Helicobacter pylori, Stomach CarcinomaEpigenetic AlterationsHelicobacter pylori infection induces aberrant DNA methylation, and methylation levels of several specific marker genes in gastric mucosa are associated with gastric cancer risk.26354778
Communicable DiseasesEpigenetic AlterationsIn conclusion, smoking habits and green/yellow vegetable intake were associated with DNA methylation levels in gastric mucosae of healthy individuals with current H.pylori infection.26354778
Ventricular hypertrophy, Hypertensive diseaseEpigenetic AlterationsHypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension.26358152
Cardiovascular Diseases, Cardiac HypertrophyEpigenetic AlterationsMicroRNAs regulate several aspects of physiological and pathologic cardiac hypertrophy, and they represent promising therapeutic targets in cardiovascular disease.26358152
Hypertensive diseaseEpigenetic AlterationsWe assessed the expression levels of the microRNAs miR-1, miR-133a, miR-26b, miR-208b, miR-499, and miR-21, in 102 patients with essential hypertension and 30 healthy individuals.26358152
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-related single-nucleotide polymorphism of XPO5 is strongly correlated with the prognosis and chemotherapy response in advanced non-small-cell lung cancer patients.26358254
Progeria, Cell Cycle, Loss, DNA DamageEpigenetic AlterationsProgeria cells display progerin and prelamin A nuclear accumulation, altered histone methylation pattern, heterochromatin loss, increased DNA damage and cell cycle alterations.26359359
Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer DNA methylation patterns from patients in Manaus, Brazil.26363785
NeoplasmsEpigenetic AlterationsDNA methylation is commonly linked with the silencing of the gene expression for many tumor suppressor genes.26363785
Malignant NeoplasmsEpigenetic AlterationsAs such, determining DNA methylation patterns should aid, in times to come, in the diagnosis and personal treatment for various types of cancers.26363785
Hyperglycemia, InflammationEpigenetic AlterationsOur results showed the association of hyperglycemia with increased DNA damage and aberrant expression of miRNAs and genes related to several biological processes, such as inflammation, DNA repair, ROS production and antioxidant defense, highlighting the importance of proper glycemic control.26364207
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsMoreover, the transcriptional expression of miRNAs provided novel information for understanding the regulatory mechanisms involved in the T2D progression.26364207
Acute Coronary SyndromeEpigenetic AlterationsDecision-making microRNAs (miR-124, -133a/b, -34a and -134) in patients with occluded target vessel in acute coronary syndrome.26365938
AMD1 wt AlleleEpigenetic AlterationsDifferences in miRNA serum profile exist between patients with wet and dry form of AMD, which indicates miRNAs as potential biomarkers of AMD.26366973
AMD1 wt AlleleEpigenetic AlterationsSerum MicroRNAs as Potential Biomarkers of AMD.26366973
ArteriosclerosisEpigenetic AlterationsAltered Plasma MicroRNAs as Novel Biomarkers for Arteriosclerosis Obliterans.26370316
Airway structureEpigenetic AlterationsIt remains unknown how fine particulate matter (PM2.5) constituents affect differently the fractional concentration of exhaled nitric oxide (FeNO, a biomarker of airway inflammation) and the DNA methylation of its encoding gene (NOS2A).26372312
Chronic Obstructive Airway DiseaseEpigenetic AlterationsOur results indicated that organic carbon, element carbon, NO3(-) and NH4(+) might be mainly responsible for the effects of PM2.5 on the decreased NOS2A DNA methylation and elevated FeNO in COPD patients.26372312
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDown-regulated MicroRNA 148b expression as predictive biomarker and its prognostic significance associated with clinicopathological features in non-small-cell lung cancer patients.26377406
Malignant neoplasm of breastEpigenetic AlterationsmiRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers.26378051
CarcinogenesisEpigenetic AlterationsmiRNA deregulation has been found to promote carcinogenesis.26378051
Mammary NeoplasmsEpigenetic AlterationsLittle is known about miRNA deregulation in hereditary breast tumors as no miRNA expression profiling studies have been performed in normal breast tissue of BRCA1 and BRCA2 mutation carriers.26378051
Breast CarcinomaEpigenetic AlterationsmiRNA profiles of 17 BRCA1- and 9 BRCA2-associated breast carcinomas were analyzed using microarrays.26378051
Breast CarcinomaEpigenetic AlterationsBreast carcinomas showed extensive miRNA alteration compared to normal breast tissues in BRCA1 and BRCA2 mutation carriers.26378051
CarcinogenesisEpigenetic AlterationsThis study provides a comprehensive insight into the potential role of miRNA deregulation in BRCA1/2-associated breast carcinogenesis.26378051
Liver carcinomaEpigenetic AlterationsSerum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma.26380927
Hollings Cancer Center, Complete atrioventricular blockEpigenetic AlterationsAdditionally, the serum levels of circulating microRNAs showed a smaller difference between HCC and either CHB or LC.26380927
Hollings Cancer CenterEpigenetic AlterationsThis study suggests that serum exosomal microRNAs may be used as novel serological biomarkers for HCC.26380927
Stomach CarcinomaEpigenetic AlterationsLong noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression.26384350
Malignant Neoplasms, Stomach CarcinomaEpigenetic AlterationsCurrent evidence suggests that long noncoding RNAs (lncRNAs) may be an important class of functional regulators involved in human cancers development, including gastric cancer (GC).26384350
Lichen PlanusEpigenetic AlterationsDiagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients.26389700
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsColorectal cancer (CRC) develops through the deregulation of gene expression and the accumulation of epigenetic abnormalities, leading to tumor cell acquisition of malignant features.26389729
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) play a critical role in cancer development, where they can act as oncogenes or oncosuppressors.26389729
Multiple Myeloma, ExtramedullaryEpigenetic AlterationsIn this report, we show circulating microRNA distinguishing multiple myeloma patients with extramedullary disease from myeloma patients without such manifestation and from healthy donors.26389804
Multiple Myeloma, ExtramedullaryEpigenetic AlterationsCirculating microRNA-130a distinguished myeloma patients with extramedullary disease from healthy donors with specificity of 90.0% and sensitivity of 77.1%, patients with extramedullary disease from newly diagnosed multiple myeloma patients with specificity of 77.1% and sensitivity of 34.3% in the test cohort and with specificity of 91.7% and sensitivity of 30.0% in the validation cohort of patients.26389804
Sarcoma, MyeloidEpigenetic AlterationsCirculating microRNA-130a in patients with extramedullary myeloma was associated with bone marrow plasma cells infiltration.26389804
Sarcoma, Myeloid, Extramedullary, Neoplasms, Multiple MyelomaEpigenetic AlterationsFurther, microRNA-130a was decreased in bone marrow plasma cells obtained from patients with extramedullary myeloma in comparison to bone marrow plasma cells of myeloma patients without such manifestation, but it was increased in tumor site plasma cells of patients with extramedullary disease compared to bone marrow plasma cells of such patients (p<0.0001).26389804
ovarian neoplasmEpigenetic AlterationsExpression and prognostic significance of microRNA-451 in human epithelial ovarian cancer.26390704
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-451 has been proved to be downregulated in many human malignancies and correlated with tumor progression.26390704
Squamous cell carcinoma, MetastasisEpigenetic AlterationsIdentification and validation of WISP1 as an epigenetic regulator of metastasis in oral squamous cell carcinoma.26391330
Malignant NeoplasmsEpigenetic AlterationsThe microRNA, miR-200c, is involved in the tumorigenesis and progression of a variety of cancers.26392416
HepatocarcinogenesisEpigenetic AlterationsHere, we identified a novel long noncoding RNA (lncRNA) DBH-AS1 involved in the HBx-mediated hepatocarcinogenesis.26393879
HypercholesterolemiaEpigenetic AlterationsHistone acetylation regulates orphan nuclear receptor NR4A1 expression in hypercholesterolaemia.26396259
Hypercholesterolemia, InflammationEpigenetic AlterationsThus we conclude that histone acetylation contributes to the regulation of NR4A1 expression in hypercholesterolaemia, and that NR4A1 expression reduces hypercholesterolaemia-induced inflammation.26396259
NeoplasmsEpigenetic AlterationsA total of 29 miRNAs were identified to be differentially expressed between AAN-UUC and non-AAN-UUC tissues and these miRNA target genes in FGFR3 and Akt pathways, which regulate cell growth and tumor progression, respectively.26397152
Clinical CoordinatorEpigenetic AlterationsWe also demonstrated that the CRC-113 gene signature reflected both genetic and epigenetic molecular heterogeneity in CRC patients.26397224
Stomach CarcinomaEpigenetic AlterationsA recent discovery revealed that microRNAs (miRNAs) have an essential effect in the development and progression of gastric cancer (GC).26398444
Non-Metastatic CarcinomaEpigenetic AlterationsEpithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma.26398721
Non-Metastatic CarcinomaEpigenetic AlterationsIt was hypothesized that the overexpression of EMP3 was correlated with the downregulation of microRNA-765 (miR-765), an underexpressed miRNA in primary breast carcinoma tissues.26398721
11p15.5Epigenetic AlterationsGene expression, somatic copy number variation of chr11p15.5, and DNA methylation status of three differential methylated regions of the IGF2/H19 locus including the H19 imprinting control region were integratively analyzed.26400872
Admitting diagnosis, Impaired T cell functionEpigenetic AlterationsSuch epigenetic alteration might contribute to neural cell dysfunction in AD brain.26402071
Admitting diagnosisEpigenetic AlterationsFive miRNA were differentially expressed in CSF of AD patients.26402772
Admitting diagnosisEpigenetic AlterationsIn early-onset AD, twelve miRNA were differentially expressed of which lower abundance of miRNA-532-3p remained borderline significant (log10RQ -1.27, p = 0.05).26402772
Primary malignant neoplasmEpigenetic AlterationsModulation of epigenetic patterns has promising efficacy for treating cancer.26404510
Primary malignant neoplasmEpigenetic Alterations5-Hydroxymethylated cytosine (5-hmC) is an epigenetic mark potentially important in cancer.26404510
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsHere we report that 5-hmC is an epigenetic hallmark of prostate cancer (PCa) progression.26404510
NeoplasmsEpigenetic AlterationsThus, DNA modification directly links the TET2-dependent epigenetic pathway regulated by AR to 5-hmC-mediated tumour progression.26404510
Fibrosis AssessmentEpigenetic AlterationsIndividual miRNA had moderate diagnostic value for diffuse myocardial fibrosis (AUC: 0.663-0.742), but the diagnostic value was greatly improved (AUC: 0.87) for a combination of 8 miRNAs.26404540
Hypertrophic Cardiomyopathy, Fibrosis AssessmentEpigenetic AlterationsCirculating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy.26404540
Cardiovascular DiseasesEpigenetic AlterationsCirculating microRNAs may represent novel markers for cardiovascular diseases.26404540
Health maintenance, Fibrosis AssessmentEpigenetic AlterationsFrom the results of this initial array, 16 miRNAs were selected based on their fold changes and relevance to myocardial fibrosis for further validation by Taqman real-time PCR in 55 HCM patients.26404540
Health maintenance, Fibrosis AssessmentEpigenetic AlterationsThese findings suggest that circulating miRNAs provide attractive candidates as putative biomarkers for diffuse myocardial fibrosis in HCM.26404540
Acute lymphocytic leukemiaEpigenetic AlterationsCirculating microRNA expression profile in B-cell acute lymphoblastic leukemia.26406572
Acute lymphocytic leukemiaEpigenetic AlterationsAcute lymphoblastic leukemia (ALL) is a highly diverse disease characterized by cytogenetic and molecular abnormalities, including altered microRNA (miRNA) expression signatures.26406572
MIR199A1 geneEpigenetic AlterationsSeventy-seven circulating miRNA differentially expressed: hsa-miR-511, -222, and -34a were overexpressed, whereas hsa-miR-199a-3p, -223, -221, and -26a were underexpressed (p values < 0.005 for both sets).26406572
NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs) are small non-coding RNAs that play important role in a variety of biological processes, and aberrant expression of miRNA is always associated with tumor progression and invasion.26406866
CarcinogenesisEpigenetic AlterationsAberrant changes in DNA methylation may be an early event in carcinogenesis.26407953
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsmiRNA involvement has been observed in almost every type of cancer, including breast cancer.26408705
MIR21 gene, Necrosis, iron, Ductal CarcinomaEpigenetic AlterationsmiR21 was down-regulated in 93.3% of patients with necrosis [p=0.017 (Fishers exact test (FE))], while at least one oncogenic miRNA was up-regulated in 87.3% of the patients with invasive ductal carcinoma [p=0.009 (FE)].26408705
Breast CarcinomaEpigenetic AlterationsBased on this preliminary study, we suggest that these miRNAs, especially let7a and miRNA21, might be useful markers in follow-up of breast cancer and in prognosis.26408705
Loss of HeterozygosityEpigenetic Alterations(iii) The relation of biallelic loss to miRNA expression was less clear but appeared to favor higher miRNA levels: of 60 miRNA-target gene pairs, 34 pairs (57%) had higher miRNA expression with biallelic loss than without, while 26 pairs (43%) had lower miRNA expression.26409826
Multiple MyelomaEpigenetic AlterationsEpigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma.26410378
Multiple Myeloma, GammopathyEpigenetic AlterationsIn multiple myeloma, a long non-coding RNA, KIAA0495 (alias PDAM/TP73-AS1), had been found progressively downregulated from normal plasma cell to benign monoclonal gammopathy of undetermined significance to symptomatic myeloma.26410378
cervical cancerEpigenetic AlterationsMultiple protein or microRNA markers have been recognized to contribute to the progression and recurrence of cervical cancers.26411419
Carcinoma of lungEpigenetic AlterationsDNA methylation age of blood predicts future onset of lung cancer in the womens health initiative.26411804
Chronic sinusitisEpigenetic AlterationsDifferentially Expressed miRNA in Inflammatory Mucosa of Chronic Rhinosinusitis.26413631
Craniosynostosis, InflammationEpigenetic AlterationsThe RT-qPCR results indicate that the miRNAs were differentially expressed in CRS patients and various inflammation severities could lead to this difference.26413631
Esophageal carcinomaEpigenetic AlterationsMicroRNA-1 (mimics-miR-1) and its inhibitor (Inhibitor-miR-1) were transfected into esophageal cancer cells KYSE 510 and Eca 109; cell proliferation, migration, and invasion assays were carried out.26414725
Primary malignant neoplasmEpigenetic AlterationsThe gene expression level of microRNA-1 in cancer tissues was significantly lower than that in adjacent normal tissues (P < 0.01).26414725
Cerebrovascular accidentEpigenetic AlterationsMicroRNA let-7e Is a Potential Circulating Biomarker of Acute Stage Ischemic Stroke.26415639
Breast CarcinomaEpigenetic AlterationsDown-regulated microRNA-124 expression as predictive biomarker and its prognostic significance with clinicopathological features in breast cancer patients.26415857
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) have been documented as playing important roles in cancer development.26415857
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional regulators of gene expression and have shown promise as potential prognostic markers in several cancer types including BC.26416693
Primary malignant neoplasmEpigenetic AlterationsThe miRNAs associated with OS identified in our cohort were validated using an external dataset from The Cancer Genome Atlas (TCGA) project.26416693
Primary malignant neoplasmEpigenetic AlterationsAmong the known forms of miRNA packaging, tumour-derived exosome-enclosed miRNAs is thought to reflect the vital activity of cancer cells.26417675
Prostate Cancer PathwayEpigenetic AlterationsThe assessment of the exosomal fraction of urinary miRNA may present a new and highly specific method for prostate cancer diagnostics; however, this is challenged by the absence of reliable and inexpensive methods for isolation of exosomes.26417675
Prostate Cancer PathwayEpigenetic AlterationsThe miRNA profile of urinary exosomes reflects development of prostate cancer and may present a promising diagnostic tool.26417675
Primary malignant neoplasmEpigenetic AlterationsMiRNAs are small regulatory RNAs which play an important role in tumorogenesis and are being investigated as a cancer biomarker.26417675
MIR21 gene, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsOur data support a possible role of tumor epigenetic deregulation by noncoding RNA in suppressing the antitumor T-cell-mediated adaptive immune response and suggest MIR21 as a potential target for immunotherapy and prevention in colorectal cancer.26419959
MIR21 gene, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA MIR21 and T Cells in Colorectal Cancer.26419959
MIR21 geneEpigenetic AlterationsExperimental evidence suggests that microRNA MIR21 (miR-21) suppresses antitumor T-cell-mediated immunity.26419959
Clinical Coordinator, CarcinogenesisEpigenetic AlterationsHistone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC.26423403
Chronic Obstructive Airway Disease, Pulmonary Fibrosis, Primary malignant neoplasmEpigenetic AlterationsDiagnostic Performance of Plasma DNA Methylation Profiles in Lung Cancer, Pulmonary Fibrosis and COPD.26425700
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation status as a biomarker of anti-epidermal growth factor receptor treatment for metastatic colorectal cancer.26426205
Colorectal Cancer PathwayEpigenetic AlterationsIn conclusion, we found that the genome-wide DNA methylation status is a powerful epigenetic predictor of anti-EGFR treatment in patients with KRAS wild-type metastatic colorectal cancer (UMIN000005490).26426205
Esophageal carcinomaEpigenetic AlterationsIn recent years, miRNA, a small RNA molecule, has drawn much attention to researchers as a potential biomarker for esophageal cancer.26427659
Malignant NeoplasmsEpigenetic AlterationsmiR-93 and miR-143 are two miRNA molecules reported to be frequently deregulated in various cancers, including prostate, stomach, cervix, and etc.26427659
Squamous cell carcinoma of esophagusEpigenetic AlterationsThese findings suggest that the deregulation of these miRNAs may play an important role in esophageal squamous cell carcinoma.26427659
Malignant neoplasm of thyroidEpigenetic AlterationsLong noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR).26427660
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia.26430723
Malignant mesotheliomaEpigenetic AlterationsCombined circulating epigenetic markers to improve mesothelin performance in the diagnosis of malignant mesothelioma.26431916
Liver carcinomaEpigenetic AlterationsLong non-coding RNA CARLo-5 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients.26433964
Primary malignant neoplasmEpigenetic AlterationsRecently, many studies show that long non-coding RNAs (lncRNAs) play important roles in cancer biology.26433964
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature.26436590
Somatic mutation, Adult Burkitt LymphomaEpigenetic AlterationsTaken together, our results demonstrate a tight connection between somatic mutation, DNA methylation and transcriptional control in key B cell pathways deregulated differentially in Burkitt lymphoma and other germinal center B cell lymphomas.26437030
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miR) expression is commonly dysregulated in many cancers, including breast.26437339
Breast Carcinoma, NeoplasmsEpigenetic AlterationsLong noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143.26439035
Autoimmune stateEpigenetic AlterationsLong noncoding RNAs (lncRNA) play key roles in regulating autoimmunity and immunity balance.26440590
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-218 is a prognostic indicator in colorectal cancer and enhances 5-fluorouracil-induced apoptosis by targeting BIRC5.26442524
Hematologic NeoplasmsEpigenetic AlterationsCC-486, the oral formulation of azacitidine (AZA), is an epigenetic modifier and DNA methyltransferase inhibitor in clinical development for treatment of hematologic malignancies.26442612
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate protein biosynthesis and participate in the pathogenesis of various tumours.26443314
Malignant NeoplasmsEpigenetic AlterationsDNA methylation, the best known epigenetic marker, can be used as a prognostic biomarker in many cancers.26443805
Nasopharyngeal carcinomaEpigenetic AlterationsWe examined DNA methylation status and survival in nasopharyngeal carcinoma (NPC) patients.26443805
Breast CarcinomaEpigenetic AlterationsCD24 expression was analyzed by immunohistochemistry in 747 breast cancer tissues, and DNA methylation and histone modification status in the promoter region of CD24 were assessed using bisulfite sequencing and chromatin immunoprecipitation assay.26444008
Breast CarcinomaEpigenetic AlterationsFurthermore, CD24 gene expression was associated with histone acetylation independent of DNA methylation, suggesting its epigenetic regulation in breast cancer.26444008
Coronary Artery DiseaseEpigenetic AlterationsInteraction between microRNA expression and classical risk factors in the risk of coronary heart disease.26446730
Malignant tumor of colonEpigenetic AlterationsEpigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications.26447334
Liver carcinomaEpigenetic AlterationsCirculating microRNA-200 Family as Diagnostic Marker in Hepatocellular Carcinoma.26447841
Liver Cirrhosis, Hollings Cancer CenterEpigenetic AlterationsCirculating microRNA-200 family members are significantly deregulated in patients with HCC and liver cirrhosis.26447841
NeoplasmsEpigenetic AlterationsThe effect of epigenetic reversion in combination with chemotherapeutic drugs on apoptosis was also assessed according to the tumor p53 mutation status.26447864
Primary malignant neoplasmEpigenetic AlterationsOn the other hand, in the KATO III cancer cell line (p53 mutant), epigenetic treatment alone induced robust apoptosis, with no trans-activation of p53.26447864
ObesityEpigenetic AlterationsOur results strongly suggest that many obesity-associated SNPs are associated with proximal gene regulation, which was reflected by association of obesity risk allele genotypes with differential DNA methylation.26449484
Plaque (lesion), Carotid StenosisEpigenetic AlterationsmiRNAs were measured in the plaque shoulder of carotid plaques obtained from patients undergoing carotid endarterectomy (CEA) for 3 distinct clinical scenarios: (1) patients without previous neurological events but high-grade carotid stenosis (asymptomatic), (2) patients with an acute neurological event within 5 days of the CEA (urgent), and (3) patients undergoing CEA>5 days after a neurological event (symptomatic).26451018
Plaque, Atherosclerotic, Plaque (lesion)Epigenetic AlterationsAtherosclerotic plaque rupture is accompanied by a loss of miR-221 and miR-222 and an increase in p27Kip1 mRNA expression in the plaque shoulder, suggesting an association between these miRNAs and atherosclerotic plaque stability.26451018
Malignant tumor of colon, Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2.26452129
Malignant tumor of colonEpigenetic AlterationsIncreasing evidence reveals that aberrant expression of microRNA contributes to the development and progression of colon cancer, but the roles of microRNA-506 (miR-506) in colon cancer remain elusive.26452129
Primary Neoplasm, Malignant neoplasm of breast, Breast CarcinomaEpigenetic AlterationsAssessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour.26452468
NeoplasmsEpigenetic AlterationsOur results show that DNA methylation profiling as well as aCGH have potential as diagnostic tools in improving the clinical decisions to differentiate recurrences from a second de novo tumour.26452468
Non-Small Cell Lung CarcinomaEpigenetic AlterationsRARb Promoter Methylation as an Epigenetic Mechanism of Gene Silencing in Non-small Cell Lung Cancer.26453065
Primary malignant neoplasmEpigenetic AlterationsAn increasing association between miRNA and cancer has been recently reported.26453197
Vascular Invasion Assessment, Liver carcinomaEpigenetic AlterationsUpregulation of MicroRNA-19b predicts good prognosis in patients with hepatocellular carcinoma presenting with vascular invasion or multifocal disease.26453548
Hollings Cancer CenterEpigenetic AlterationsIn both the miRNA microarray and real-time PCR, miR-19b was significantly overexpressed in the HCC tumor compared with adjacent non-tumor liver tissues (P < 0.001).26453548
Degenerative polyarthritisEpigenetic AlterationsEvidence suggests that epigenetics plays a role in osteoarthrits (OA).26453558
Malignant Neoplasms, Neoplasms, Malignant tumor of colonEpigenetic AlterationsDNA methylation variations in gene promoter regions are well documented tumor-specific alterations in human malignancies including colon cancer, which may influence tumor behavior and clinical outcome.26453961
Malignant tumor of colonEpigenetic AlterationsHere, we describe that DNA methylation levels at CpG loci of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil (5-FU) chemotherapy with respect to overall survival and progression-free survival.26453961
Islet Cell TumorEpigenetic AlterationsMenin, the product of the Men1 gene, which is frequently mutated in pancreatic neuroendocrine tumors, acts as a chromatin-remodeling factor to modulate the transcription of cell cycle regulators by interacting with histone modification factors.26454216
Stomach CarcinomaEpigenetic AlterationsMicroRNA profiles were generated from plasma samples of 5 patients with gastric cancer (GC) versus 5 healthy controls (HC).26456959
Primary malignant neoplasmEpigenetic AlterationsIt was reported that circulating microRNAs could be applied as non-invasive biomarkers for cancer monitoring.26456959
Primary Malignant Liver NeoplasmEpigenetic AlterationsThe Correlation Relationship between P14ARF Gene DNA Methylation and Primary Liver Cancer.26457819
Primary Malignant Liver NeoplasmEpigenetic AlterationsDNA methylation plays an important role in the process of primary liver cancer occurrence and development.26457819
Primary Malignant Liver NeoplasmEpigenetic AlterationsP14ARF mRNA level is regulated by DNA methylation in primary liver cancer.26457819
Tetranitromethane, Primary Malignant Liver NeoplasmEpigenetic AlterationsP14ARF gene DNA methylation may be associated with the occurrence of primary liver cancer occurrence and TNM staging.26457819
Malignant NeoplasmsEpigenetic AlterationsSpecific microRNA (miRNA) expression signatures have been identified in a variety of human cancers.26458593
melanomaEpigenetic AlterationsLoss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma.26462027
melanomaEpigenetic AlterationsThat loss of the epigenetic biomarker, 5-hydroxymethylcytosine (5-hmC), is a hallmark for melanoma and correlates with virulence prompted us to explore the diagnostic utility and biological implications of 5-hmC immunohistochemistry (IHC) in melanomas with small cell/nevoid subpopulations.26462027
Glioblastoma Multiforme PathwayEpigenetic AlterationsSo we could say that epigenetic modification is a crucial mechanism for controlling the expression of miR-126 in glioma.26463235
Glioma, NeoplasmsEpigenetic AlterationsRecently, several studies showed that the activation of the oncogenes and the inactivation and/or loss of the tumor suppressor genes, especially for miRNA-21, let-7 and so on, are the most primary molecule event in gliomas.26463235
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe expression level of miRNA-126 was found to be significantly higher in the control group (0.6134 +- 0.1214) than in the glioma group (0.2771 +- 0.1529; P < 0.05).26463235
Glioblastoma Multiforme PathwayEpigenetic AlterationsOur results indicate that we verified successfully the miRNA-126 down-regulation phenomenon in patients with glioma which showed in the results of glioma tissue miRNAs chip and the miRNA-126 down-regulation through methylation in patients with glioma.26463235
Inflammatory Bowel DiseasesEpigenetic AlterationsSparse Modeling Reveals miRNA Signatures for Diagnostics of Inflammatory Bowel Disease.26466382
ibudilastEpigenetic AlterationsThese results suggest that the proposed miRNA signature is of relevance for the etiology of IBD.26466382
Liver carcinoma, NeoplasmsEpigenetic AlterationsmicroRNA-622 acts as a tumor suppressor in hepatocellular carcinoma.26467022
NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs) are important regulators of tumor development and progression.26467022
Primary malignant neoplasmEpigenetic AlterationsMoreover, we put forward the hypothesis that there are regulatory relationships between oncogenes and TSGs apart from the functional synergy of both; the oncogene-miRNA-TSG networks are one of mechanisms among the regulatory relationships; the regulatory relationships and the networks might play active roles in the development and progression of cancer.26467212
Hollings Cancer CenterEpigenetic AlterationsRecently, numerous studies highlighted that microRNAs (miRNAs) were significantly differentially expressed in HCC tumorigenesis, and the expression was tissue-specific, indicating that miRNAs may cause great epigenetic changes in HCC tumorigenesis.26468017
Hematologic NeoplasmsEpigenetic AlterationsIncreasing evidences indicate that deregulation of microRNAs (miRNAs) might plays an important role in hematologic malignancies, including MPN.26468945
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsColorectal cancer (CRC) is a heterogeneous disease caused by genetic and epigenetic alterations.26471487
Chronic Kidney DiseasesEpigenetic AlterationsPlasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise.26475583
Chronic Kidney DiseasesEpigenetic AlterationsThe differential expression in circulating miRNA in response to acute and chronic exercise may point toward a physiological role in cardiovascular adaptation to exercise, also in CKD.26475583
TP53COR1 geneEpigenetic AlterationsLincRNA-p21 is a long intergenic noncoding RNA, which is located on chromosome 17, approximately 15 kb upstream from the Cdkn1a (p21) gene.26475621
Breast CarcinomaEpigenetic AlterationsA circulating miRNA signature as a diagnostic biomarker for non-invasive early detection of breast cancer.26476723
Breast CarcinomaEpigenetic AlterationsWe first conducted miRNA profiling of these 96 miRNAs by SdM-RT-PCR using the sera of 25 breast cancer patients at diagnosis prior to treatment and 20 age-matched healthy controls.26476723
Breast CarcinomaEpigenetic AlterationsA miRNA signature was validated in an independent set of 128 serum samples composed of 76 breast cancer patients and 52 healthy controls.26476723
Breast CarcinomaEpigenetic AlterationsFurthermore, the identified 3-miRNA signature is a promising circulating biomarker for breast cancer diagnosis.26476723
Breast CarcinomaEpigenetic AlterationsCirculating microRNAs (miRNAs) show potential for breast cancer detection, but the existing results appear to be mixed.26476723
Breast CarcinomaEpigenetic AlterationsNinety-three miRNAs dysregulated or with functions in breast cancer were selected as candidates, and additional 3 miRNAs were chosen as endogenous controls.26476723
Breast CarcinomaEpigenetic AlterationsIn the discovery stage, we identified 23 miRNAs as significantly dysregulated in breast cancer patients compared with healthy controls.26476723
Breast CarcinomaEpigenetic AlterationsOf these, 10 miRNAs were previously identified as dysregulated in breast cancer; 14 miRNAs remained significant after P-values were adjusted by both correction methods.26476723
ovarian neoplasmEpigenetic AlterationsThe dysfunction of miRNA contributes to ovarian cancer development.26477861
Cholangiocarcinoma, Choledochal CystEpigenetic AlterationsExpression profile of microRNA-200 family in cholangiocarcinoma arising from choledochal cyst.26479153
Malignant NeoplasmsEpigenetic AlterationsEpithelial-to-mesenchymal transition (EMT) is considered a critical step for various solid cancers, which is regulated by the microRNA-200 (miR-200) family.26479153
Esophageal carcinomaEpigenetic AlterationsMicroRNAs (miRNAs) have been associated with prognosis in esophageal cancer, suggesting a role for miRNAs to help guide treatment decisions.26481465
Carcinoma of lungEpigenetic AlterationsAccumulating evidence indicates that altered miRNA expression is crucially involved in lung cancer development, though scant information is available regarding how MYC, an archetypical oncogene, is regulated by miRNAs, especially via a mechanism involving MYC cofactors.26483346
Squamous cell carcinoma of the head and neck, NeoplasmsEpigenetic AlterationsTumor and normal epithelial tissues were obtained from 75 HNSCC patients to analyze selected miRNAs.26484611
Adenoma of large intestineEpigenetic AlterationsGene-specific DNA methylation of DNMT3B and MTHFR and colorectal adenoma risk.26485042
Colorectal Cancer PathwayEpigenetic AlterationsPolymorphisms in these genes have been implicated in colorectal cancer etiology; however, epigenetic modifications such as gene-specific DNA methylation also affect gene expression.26485042
Adenoma of large intestineEpigenetic AlterationsNo association was observed between average DNA methylation of either DNMT3B or MTHFR and colorectal adenoma risk.26485042
Adenoma of large intestineEpigenetic AlterationsFor DNMT3B, increasing DNA methylation of CpG sites in the gene-coding area was associated with a higher risk of colorectal adenomas (OR=1.34; 95% CI: 1.01-1.79 per SD).26485042
ovarian neoplasmEpigenetic AlterationsOf these, 10 miRNAs (miR-193a-5p, miR-375, miR-339-3p, miR-340-5p, miR-532-3p, miR-133a-3p, miR-25-3p, miR-10a-5p, miR-616-5p, and miR-148b-5p) displayed fold changes in concentration ranging from -2.9 to 4 (p<0.05), in recurrent platinum resistant ovarian cancer patients, that were associated with response to decitabine followed by carboplatin chemotherapy.26485143
Prostate Cancer PathwayEpigenetic AlterationsIdentification of specific DNA methylation sites on the Y-chromosome as biomarker in prostate cancer.26485765
Behcet SyndromeEpigenetic AlterationsGlobal microRNA profiling of peripheral blood mononuclear cells in patients with Behcets disease.26486198
F9 geneEpigenetic AlterationsMicroRNA expressions can be linked to the development of LNM of PTC.26487287
F9 geneEpigenetic AlterationsWe confirmed already described up-regulations of microRNAs in PTC, such as miR-146b-5p or miR-222-3p, but we also identified down-regulated microRNAs, such as miR-7-5p or miR-30c-2-3p.26487287
F9 geneEpigenetic AlterationsIn addition, 12 of the 14 down-regulated microRNAs are significantly less expressed in aggressive PTC compared to non-aggressive PTC.26487287
Malignant Neoplasms, Colorectal Cancer Pathway, Clinical CoordinatorEpigenetic AlterationsMounting evidence indicates that one specific miRNA: miR-320b is down regulated in numerous human cancers, including colorectal cancer (CRC); making the hypothesis that miR-320b may play a key role in tumorigenesis plausible.26487644
Hepatitis, Liver carcinomaEpigenetic AlterationsHepatic DNA Methylation Is Affected by Hepatocellular Carcinoma Risk in Patients with and without Hepatitis Virus.26489010
Hollings Cancer CenterEpigenetic AlterationsHere, we identified HCC risk factors that are associated with DNA methylation in the background liver tissue of NBNC-HCC patients.26489010
Hollings Cancer CenterEpigenetic AlterationsOn the other hand, epigenetic alterations are reportedly responsible for HCC development.26489010
Malignant neoplasm of breastEpigenetic AlterationsThe BRCA1 gene plays a key role in triple negative breast cancers (TNBCs), in which its expression can be lost by multiple mechanisms: germinal mutation followed by deletion of the second allele; negative regulation by promoter methylation; or miRNA-mediated silencing.26490435
Malignant neoplasm of breastEpigenetic AlterationsEvaluation of BRCA1-related molecular features and microRNAs as prognostic factors for triple negative breast cancers.26490435
NeoplasmsEpigenetic AlterationsMaintenance of expressed BRCA1 protein interaction with BARD1 was quantified, as a marker of BRCA1 functionality, and the tumor expression profiles of 27 microRNAs were determined.26490435
Mucoepidermoid carcinoma of salivary glandEpigenetic AlterationsEpigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration.26490796
CarcinogenesisEpigenetic AlterationsMicroRNAs have been proposed as significant regulators of carcinogenesis, and several of them have been demonstrated to have direct roles in survival of CSLCs.26490990
Glioma, Glioblastoma Multiforme PathwayEpigenetic AlterationsTaken together, DNA-based large-scale molecular profiling indicates that GC comprises a genetically and epigenetically heterogeneous group of diffuse gliomas that carry DNA methylation and copy number profiles closely matching the common molecularly defined glioma entities.26493382
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-200c as a Prognostic Biomarker for Pancreatic Cancer.26493507
Metastasis, Primary malignant neoplasmEpigenetic AlterationsIn cancer biology, miRNA affects the growth and metastasis of cancer cells by controlling epithelial-mesenchymal transition (EMT).26493507
Carcinoma of lungEpigenetic AlterationsAs chip-digital PCR becomes more established, it would be a robust tool for quantitative assessment of miRNA copy number for diagnosis of lung cancer and other diseases.26493562
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are a new promising class of circulating biomarkers for cancer detection, but lack of consensus on data normalization methods has affected the diagnostic potential of circulating miRNAs.26493562
Traumatic injuryEpigenetic AlterationsEpigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma.26496100
Antilymphocyte SerumEpigenetic AlterationsMany of the genes associated with genetic ALS have pathological biological pathways related to RNA metabolism, and their pathogenesis may be affecting the maturing processes of miRNA.26497046
Cartilage injuryEpigenetic AlterationsThree novel miRNAs were regulated across models of chondrogenesis, chondrocyte differentiation or cartilage injury.26497608
ovarian neoplasmEpigenetic AlterationsHOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer.26497652
ovarian neoplasmEpigenetic AlterationsWe analyzed HOTAIR expression and associated surrogate DNA methylation (DNAme) in 134 primary ovarian cancer cases (63 received carboplatin, 55 received cisplatin and 16 no chemotherapy).26497652
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA expression profiling identifies miR-31-5p/3p as associated with time to progression in wild-type RAS metastatic colorectal cancer treated with cetuximab.26497852
Purpura, Thrombotic ThrombocytopenicEpigenetic AlterationsMiRNAs expression profiling was performed on the exploratory cohort of 41 wt-KRAS mCRC patients treated with cetuximab to identify miRNAs associated with time to progression (TTP).26497852
Esophageal carcinomaEpigenetic AlterationsFive miRNAs Considered as Molecular Targets for Predicting Esophageal Cancer.26498375
Cardiac dysfunctionEpigenetic AlterationsRecently, it has been recognized that changes in microribonucleic acid (miRNA) expression may lead to cardiac dysfunction.26498537
NeoplasmsEpigenetic AlterationsAccumulating data suggested that hsa-microRNAs (miRNAs) could be potential biomarkers for tumor diagnosis due to their important roles in the cell cycle.26499781
CHOANAL ATRESIA, POSTERIOR, NeoplasmsEpigenetic AlterationsThe average relative expressions of hsa-miR-203 and hsa-miR-30c in tumor tissues were significantly different from those in adjacent normal tissues (P < 0.001), and the predictive power of the two hsa-miRNAs for PCa prognosis was reliable.26499781
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-613 (miR-613) plays important roles in tumorigenesis and cancer progression.26499784
NeoplasmsEpigenetic AlterationsHowever, expression instability of reference genes in tumors may introduce bias when determining miRNA levels.26499892
Pancreatic carcinomaEpigenetic AlterationsSmall nucleolar RNA U91 is a new internal control for accurate microRNAs quantification in pancreatic cancer.26499892
ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsRT-qPCR quantification of miRNAs expression may play an essential role in pancreatic ductal adenocarcinoma (PDAC) diagnostics.26499892
NeoplasmsEpigenetic AlterationsThus, statistically significant and insignificant differences between tumors and normal tissues for miRNAs were equal for the spike and the U91.26499892
NeoplasmsEpigenetic AlterationsThe microRNA miR-19a is overexpressed in many solid tumours and regulates the suppressor of cytokine signalling-1 (SOCS-1) expression.26502748
intracranial gliomaEpigenetic AlterationsThe expression of microRNA-449a in brain tissue or peripheral blood of patients with brain glioma was significantly lower than that of normal people, and the differences were statistically significant (p < 0.05).26502848
Glioblastoma Multiforme PathwayEpigenetic AlterationsUpon interfering with microRNA-449a, the glioma cell proliferation was significantly increased while apoptosis was significantly reduced, the PKCa protein levels were increased significantly and the differences were statistically significant (all p < 0.05); after overexpression of microRNA-449a, the glioma cell proliferation was significantly decreased while the cell apoptosis was significantly increased, the PKCa protein levels were decreased significantly and the differences were statistically significant (all p < 0.05).26502848
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe expression of microRNA-449a is low in patients with glioma, which may inhibit the proliferation of glioma and promote its cell apoptosis via affecting the expression of PKCa.26502848
ovarian neoplasmEpigenetic AlterationsLong non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway.26503132
Hepatitis CEpigenetic AlterationsMiravirsen dosing in chronic hepatitis C patients results in decreased microRNA-122 levels without affecting other microRNAs in plasma.26503793
Hepatitis CEpigenetic AlterationsMicroRNA-122 (miR-122) is an important host factor for hepatitis C virus replication.26503793
Islet Cell TumorEpigenetic AlterationsEndoplasmic Reticulum Stress in Pancreatic Neuroendocrine Tumors is Linked to Clinicopathological Parameters and Possible Epigenetic Regulations.26504039
Malignant Pleural MesotheliomaEpigenetic AlterationsMethylation-associated Silencing of microRNA-126 and its Host Gene EGFL7 in Malignant Pleural Mesothelioma.26504055
1-methyl-1-piperidinomethane sulfonate, Malignant Pleural MesotheliomaEpigenetic AlterationsWe recently reported that miR-126 is down-regulated in malignant pleural mesothelioma (MPM) and can be combined into a 4-microRNA-classifier that can accurately diagnose MPM with high sensitivity and specificity.26504055
Malignant Neoplasms, Malignant neoplasm of endometrium, CarcinogenesisEpigenetic AlterationsEndometrial cancer is the most common malignancy of the female genital tract while aberrant DNA methylation seems to play a critical role in endometrial carcinogenesis.26504828
Non-Small Cell Lung CarcinomaEpigenetic AlterationsRelationship of EGFR DNA methylation with the severity of non-small cell lung cancer.26505339
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsIn summary, our results suggest that the DNA methylation levels of EGFR can be used as an important indicator for the stage of cancer tissue malignancy.26505339
Pancreatic carcinomaEpigenetic AlterationsPlasma microRNA profiles: identification of miR-744 as a novel diagnostic and prognostic biomarker in pancreatic cancer.26505678
Colorectal Cancer PathwayEpigenetic AlterationsLong non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer.26506418
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsWe determined expression of 83 long non-coding RNAs (lncRNAs) and identified ZFAS1 to be significantly up-regulated in colorectal cancer (CRC) tissue.26506418
SF3B1 wt AlleleEpigenetic AlterationsThese data suggest that mutations in epigenetic modification and splicesome genes are common in Chinese patients with MDS, while mutations in U2AF1 and SRSF2 appear to predict an unfavorable prognosis.26508027
Hollings Cancer CenterEpigenetic AlterationsSerum and tissue microRNA levels were compared in 14 patients surgically treated for HCC.26509672
Cirrhotic, Hollings Cancer CenterEpigenetic AlterationsCirculating microRNAs, miR-939, miR-595, miR-519d and miR-494, Identify Cirrhotic Patients with HCC.26509672
Hollings Cancer CenterEpigenetic AlterationsTherefore, we show that circulating microRNAs deserve attention as non-invasive biomarkers in the diagnostic setting of HCC and that exosomal secretion contributes to discharging a subset of microRNAs into the extracellular compartment.26509672
Prostate Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsTumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer.26509963
CHOANAL ATRESIA, POSTERIOR, MetastasisEpigenetic AlterationsElucidation of the molecular pathways modulated by tumor-suppressive miRNAs provides insights into the mechanisms of PCa progression and metastasis.26509963
Colorectal NeoplasmsEpigenetic AlterationsGenetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway.26510091
Clinical Coordinator, Colorectal Cancer Pathway, Sessile Serrated Adenoma/Polyp, Traditional Serrated AdenomaEpigenetic AlterationsTo clarify molecular alterations in serrated pathway of colorectal cancer (CRC), we performed epigenetic and genetic analyses in sessile serrated adenoma/polyps (SSA/P), traditional serrated adenomas (TSAs) and high-methylation CRC.26510091
Breast CarcinomaEpigenetic AlterationsExploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation.26510686
Breast CarcinomaEpigenetic AlterationsBreast cancer formation is associated with frequent changes in DNA methylation but the extent of very early alterations in DNA methylation and the biological significance of cancer-associated epigenetic changes need further elucidation.26510686
Primary malignant neoplasmEpigenetic AlterationsIn addition, examination of transcriptome and DNA methylation databases indicated that methylation at three non-promoter regions (far-upstream EN1 and PITX2 and intronic LHX2) was associated with higher gene expression, unlike the inverse associations between cancer DNA hypermethylation and cancer-altered gene expression usually reported.26510686
Breast CarcinomaEpigenetic AlterationsWe confirmed the frequent DNA methylation changes in invasive breast cancer at a variety of genome locations and found evidence for an extensive field effect in breast cancer.26510686
Primary malignant neoplasmEpigenetic AlterationsIn addition, we illustrate the power of combining publicly available whole-genome databases with a candidate gene approach to study cancer epigenetics.26510686
Squamous cell carcinoma of esophagusEpigenetic AlterationsEpigenetic silencing of HIC1 promotes epithelial-mesenchymal transition and drives progression in esophageal squamous cell carcinoma.26510908
Squamous cell carcinoma of esophagusEpigenetic AlterationsTogether, loss of the regulation of EphA2 pathway through HIC1 epigenetic silencing could be an important mechanism in the ESCC progression.26510908
palladiumEpigenetic AlterationsIt identifies changes in crucial components of chromatin remodeling and methylation machineries as early events in sporadic PD suggesting epigenetics as target for therapeutic intervention.26510930
NeoplasmsEpigenetic AlterationsOur aim was to determine if the distributions of clinicopathologic factors in CIMP-positive tumors with MLH1 DNA methylation differed from those in CIMP-positive tumors without DNA methylation of MLH1.26512054
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-206 functions as a tumor suppressor in colorectal cancer by targeting FMNL2.26515696
Clinical CoordinatorEpigenetic AlterationsMicroRNAs play important roles in the progression of CRC.26515696
Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsWe hypothesize that miR-3151, localized to a GWAS-identified chronic lymphocytic leukemia (CLL) risk locus (8q22.3), is a tumor suppressor miRNA silenced by promoter DNA methylation in CLL.26517243
ETFA gene, Chronic Lymphocytic LeukemiaEpigenetic AlterationsmiR-3151 silencing by DNA methylation protected CLL cells from apoptosis through over-expression of its direct targets MADD and PIK3R2, hence constitutive activation of MEK/ERK and PI3K/AKT signaling respectively, and consequently over-expression of MCL1.26517243
Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsEpigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways.26517243
Primary malignant neoplasmEpigenetic AlterationsVarious miRNAs have recently emerged as potential prognostic biomarkers in cancer.26517683
NeoplasmsEpigenetic AlterationsFurthermore, we show that the expression of these miRNAs is decreased in high grade and stage tumors, and the down-regulation is associated with patients poor clinical outcome.26517683
Malignant neoplasm of urinary bladderEpigenetic AlterationsTetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells.26517688
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsRecent studies show that long non-coding RNAs (lncRNAs) may be significant functional regulators in tumor development, including bladder cancer.26517688
Colorectal Cancer PathwayEpigenetic AlterationsComparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer.26518883
NeoplasmsEpigenetic AlterationsBecause epigenetic silencing is the hallmark of a tumor suppressor we tested eta in focus formation assays and found that it is capable of suppressing ras-induced transformation of NIH3T3 cells.26518883
Inflammatory disorderEpigenetic AlterationsMicroRNAs (miRNAs) are short non-coding RNAs whose expression profiles can serve as diagnostic biomarkers and which may be involved in the pathophysiology of neuroinflammatory diseases.26521232
Neuromyelitis Optica, MS geneEpigenetic AlterationsNext-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis.26521232
Degenerative polyarthritisEpigenetic AlterationsEpigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis.26521741
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDNA methylation changes are a constant feature of acute myeloid leukemia.26522083
Primary malignant neoplasmEpigenetic AlterationsGlobal DNA hypomethylation at the 5 position of cytosine (5mC) is a well-known epigenetic feature of cancer.26525607
Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsMiRNAs have been shown to be aberrantly expressed in CN-AML.26526573
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsRelease kinetics of circulating miRNA-208a in the early phase of myocardial infarction.26528525
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsThese results demonstrate that plasma miRNA-208a is an interesting and promising candidate for a new biomarker released early after onset of myocardial infarction.26528525
Tissue injuryEpigenetic AlterationsRecent scientific results suggested that microRNAs (miRNAs) might become a new biomarker of tissue injury.26528525
Malignant Neoplasms, Viral hepatitis, Liver Cirrhosis, Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsAssociation between microRNA-196A2 and microRNA-146A polymorphisms and progression to cirrhosis and hepatocellular carcinoma in patients with viral hepatitis B. MicroRNAs (miRNAs) are small noncoding RNAs that have been implicated in mechanisms underlying various types of cancers including hepatocellular carcinoma (HCC).26529280
Communicable Diseases, Hepatitis B, Liver Cirrhosis, Hollings Cancer CenterEpigenetic AlterationsReports have indicated that single nucleotide polymorphisms in miRNA-196A2 and miRNA-146A genes may contribute to the risk of progression of hepatitis B virus (HBV) infection to cirrhosis and HCC.26529280
Hollings Cancer CenterEpigenetic AlterationsOur results showed that serum levels of three microRNAs (miRNAs) were significantly decreased in HCC cases than those in benign and healthy controls (all P < 0.05).26531720
Metastasis, Hollings Cancer CenterEpigenetic AlterationsAlso, dynamic monitoring three miRNAs can help us predict recurrence or metastasis in HCC cases after surgical resection.26531720
Congenital contractural arachnodactylyEpigenetic AlterationsSeveral microRNAs (miRNAs) have been reported to be dysregulated in CCA tissues.26534789
MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROMEEpigenetic AlterationsMicroRNA expression profile of a Malaysian Bajau family with familial mitochondrial neurogastrointestinal encephalomyopathy.26535630
TYMP wt AlleleEpigenetic AlterationsIn conclusion, we demonstrate that blood miRNAs are deregulated in the pathogenesis of MNGIE and these changes may have therapeutic implications.26535630
MetastasisEpigenetic AlterationsFurther, we identified 83 genes that are associated with lymph node metastasis and correlated these with miRNA-expression.26537449
Calcification of coronary arteryEpigenetic AlterationsCirculating microRNAs correlated with the level of coronary artery calcification in symptomatic patients.26537670
caffeine/cisplatin/cytarabine protocolEpigenetic AlterationsEight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort.26537670
caffeine/cisplatin/cytarabine protocolEpigenetic AlterationsFour miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC.26537670
Lung Diseases, Obstructive, caffeine/cisplatin/cytarabine protocolEpigenetic AlterationsWe identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients.26537670
Cardiovascular DiseasesEpigenetic AlterationsMicroRNAs (miRNAs) can contribute to the development of cardiovascular diseases, and single nucleotide polymorphisms (SNPs) in miRNA genes may influence disease susceptibility by altering mature miRNA expression levels.26537765
Primary malignant neoplasmEpigenetic AlterationsOur findings that epigenetic effects of cancer metabolic reprogramming may promote DNA repair provide a molecular mechanism by which deregulation of metabolism may not only support cell growth but also maintain cell immortality, drive therapeutic resistance, and promote genomic instability.26538285
Primary malignant neoplasmEpigenetic AlterationsBy defining a pathway from deregulated metabolism to enhanced DNA damage response in cancer, these data provide a rationale for targeting downstream epigenetic effects of metabolic reprogramming to block cancer cell immortality and overcome resistance to genotoxic stress.26538285
Stomach CarcinomaEpigenetic AlterationsLINC00152 was documented as an important long non-coding RNA (lncRNA) involved in the pathogenesis of gastric cancer; however, the detailed mechanism of action of LINC00152 remains unknown.26540343
Malignant neoplasm of liver, NeoplasmsEpigenetic AlterationsLong non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1).26540633
Malignant neoplasm of liverEpigenetic AlterationsHighly up-regulated in liver cancer (HULC) is a long non-coding RNA (lncRNA).26540633
cervical cancerEpigenetic AlterationsEpigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer.26542757
Chronic Obstructive Airway DiseaseEpigenetic AlterationsWe identified 11 prognostic mRNA/miRNA predictors associated with the overall survival of COAD patients, suggesting the correlation of STIM1-associated features to clinicopathological outcomes.26543234
Malignant NeoplasmsEpigenetic AlterationsAltered salivary micro-RNA (miRNA) expression levels have been observed in saliva from patients with various cancers.26544193
Parotid NeoplasmsEpigenetic AlterationsA two miRNA combination can predict the presence of a parotid gland neoplasm.26544193
Malignant neoplasm of urinary bladderEpigenetic AlterationsLong non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway.26544536
Malignant neoplasm of urinary bladderEpigenetic AlterationsLong non-coding RNA urothelial cancer-associated 1 (lncRNA-UCA1) is highly expressed in bladder cancer tissues and cells, and it has been shown to play an important role in regulating aggressive phenotypes of bladder cancer cells.26544536
Malignant neoplasm of urinary bladderEpigenetic AlterationsNumerous studies suggest that several long non-coding RNAs (lncRNAs) play critical roles in bladder cancer development and progression.26544536
Primary malignant neoplasmEpigenetic AlterationsExamination of The Cancer Genome Atlas (TCGA) project miRNA data on 305 OSCCs and 30 controls revealed 100% of those miRNAs enriched in never smoker OSCCs in this patient group were also enriched in ever smoker OSCCs.26544609
NeoplasmsEpigenetic AlterationsNonsupervised clustering of TCGA OSCCs was suggestive of two or four subgroups of tumors based on miRNA levels with limited evidence for differences in tobacco exposure among the groups.26544609
Malignant NeoplasmsEpigenetic AlterationsResults from both patient groups together stress the importance of miR196a-5p in OSCC malignancy in both never and ever smokers, and emphasize the overall similarity of miRNA expression in OSCCs in these two risk groups.26544609
Hypodiploid B Acute Lymphoblastic LeukemiaEpigenetic AlterationsGenetic and epigenetic characterization of hypodiploid acute lymphoblastic leukemia.26544893
Initiation, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs, miRs) are small, non-coding RNAs that are likely to play significant roles in cancer initiation and progression where they may act as oncogenes or tumor suppressors.26545583
Malignant Head and Neck NeoplasmEpigenetic AlterationsMicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer.26545583
Malignant Neoplasms, Hematologic NeoplasmsEpigenetic AlterationsCytoplasmic polyadenylation element binding protein 4 (CPEB4) is a regulator of gene transcription and has been reported to be associated with biological malignancy in cancers.26546435
NeoplasmsEpigenetic AlterationsDNA methylation in the promoter regions is considered to be a mechanism through which tumor suppressor genes are inhibited, which will lead to tumorigenesis and tumor progression.26547439
Liver carcinoma, NeoplasmsEpigenetic AlterationsComprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma.26547929
Malignant Neoplasms, Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsMicroRNA-9 (miR-9) dysregulation is implicated in a variety of human malignancies including hepatocellular carcinoma (HCC), but its role remains contradictory.26547929
Stomach CarcinomaEpigenetic AlterationsPRL-3 regulates microRNA in gastric cancer.26548949
Granuloma, Radicular CystEpigenetic AlterationsThe purpose of the present investigation was to analyze the expression of MMP2 and MMP9 in periapical granulomas and radicular cysts and to test the hypothesis that, in these lesions, their transcription may be modulated by DNA methylation.26549219
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNAs play important roles in regulation of the initiation and progression of AML.26549593
BehaviorEpigenetic AlterationsRecent studies suggest that microRNAs (miRNAs) can regulate the evolution of malignant behavior by regulating multiple target genes.26549725
Prostate Cancer PathwayEpigenetic AlterationsEpigenetic silencing of the mentioned genes could be novel molecular markers for the prognosis of advanced prostate cancer.26551297
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsExpression of long noncoding RNA lncRNA-n336928 is correlated with tumor stage and grade and overall survival in bladder cancer.26551459
Alzheimers DiseaseEpigenetic AlterationsAberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimers disease.26553823
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsWe have previously reported in Alzheimers disease (AD) the mislocalization of epigenetic molecules between the cell nucleus and the cytoplasm.26553823
Admitting diagnosisEpigenetic AlterationsBecause of the known role of H3k4me3 in the expression of synaptic genes, our data suggest an epigenetic role in synaptic deficits early in the course of AD.26553823
Liver carcinomaEpigenetic AlterationsDownregulation of MicroRNA-1 is Associated with Poor Prognosis in Hepatocellular Carcinoma.26554254
OsteoporosisEpigenetic AlterationsMicroRNAs (miRNAs) are important regulators of gene expression, with documented roles in bone metabolism and osteoporosis, suggesting potential therapeutic targets.26555194
Breast Carcinoma, PsychobiologyEpigenetic AlterationsLong non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer.26555546
Rheumatoid Arthritis, Right armEpigenetic AlterationsAlthough aberrant DNA methylation has been described in rheumatoid arthritis (RA), no studies have interrogated this epigenetic modification in early disease.26556652
Right armEpigenetic AlterationsFollowing recent investigations of T and B lymphocytes in established disease, we now characterize in these cell populations genome-wide DNA methylation in treatment-naive patients with early RA.26556652
Right armEpigenetic AlterationsTreatment-naive early RA patients display novel disease-specific DNA methylation aberrations, supporting a potential role for these changes in the development of RA.26556652
Angina Pectoris, Aortic Valve StenosisEpigenetic AlterationsSerum (S) and PF from patients undergoing coronary artery bypass graft (CABG) due to stable angina pectoris (sAP) and unstable AP (uAP) and aortic valve replacement due to aortic stenosis (AS) were analyzed for the detection of miRNAs.26562412
Diabetic NephropathyEpigenetic AlterationsRs12976445 Polymorphism is Associated with Risk of Diabetic Nephropathy Through Modulating Expression of MicroRNA-125 and Interleukin-6R.26563755
Breast CarcinomaEpigenetic AlterationsNone of the 13 serum proteins nor miRNA 135b identified women with HRN or TN breast cancer.26565788
NeoplasmsEpigenetic AlterationsNinety-eight patients with tumor specimens from 2 timepoints were measured for DNA methylation in the promoter regions across 4 genes.26566081
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA profiling in serum and tissue samples to assess noninvasive biomarkers for NSCLC clinical outcome.26566629
Non-Small Cell Lung Carcinoma, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsIn NSCLC, the altered expression of some miRNAs in primary tumor tissues has been correlated with diagnosis and prognosis, while the role of circulating miRNAs as cancer biomarkers is currently emerging.26566629
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese data suggest the possibility to monitor affected patients through serum and/or tissue samples, analyzing the altered expression of specific miRNAs, in order to detect prognostic biomarkers in the NSCLC.26566629
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThe DNA methylation regulator TET2 is frequently mutated in AML, and we hypothesized that studying TET2-specific differentially methylated CpGs (tet2-DMCs) improves AML classification.26568194
Primary malignant neoplasmEpigenetic AlterationsIn The Cancer Genome Atlas (TCGA) dataset where DNA methylation was analyzed by a different platform, tet2-DMC-low methylation was also associated with improved outcome (median survival = 55 vs 15 months, P = .0003) and was a better predictor of survival than mutations in TET2, IDH1, or IDH2, individually or combined.26568194
Ulcerative ColitisEpigenetic AlterationsSite-Specific MicroRNA Expression May Lead to Different Subtypes in Ulcerative Colitis.26569605
Inflammation, Primary malignant neoplasmEpigenetic AlterationsMiRNA are reported as a connecting link between inflammation and cancer.26569605
Crohn DiseaseEpigenetic AlterationsDifferential miRNA expression is reported in Crohns disease (CD) patients involving various regions of the gastrointestinal tract.26569605
Clinical Coordinator, Ulcerative ColitisEpigenetic AlterationsTaking our data and previous reports into consideration, we propose that differential miRNA expression during UC perhaps contribute in the development of UC-associated CRC at the rectosigmoid area.26569605
Malignant Head and Neck NeoplasmEpigenetic AlterationsEpigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.26572146
Malignant neoplasm of kidneyEpigenetic AlterationsMicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9.26573018
Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsMicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction.26573378
Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA (miR)-1246 is involved in differentiation, invasion, metastasis and chemoresistance of certain types of tumor cells.26573378
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn particular, the miRNA let-7 has been suggested to regulate the expression of the KRAS gene, a common mutated gene in non-small cell lung cancer (NSCLC), through a let-7 complementary site (LCS) in 3UTR of KRAS mRNA.26573509
cervical cancerEpigenetic AlterationsLong noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21.26574780
Malignant NeoplasmsEpigenetic AlterationsRecent research has found that long noncoding RNAs (lncRNAs) were involved in various human cancers.26574780
Metastasis, Neoplasms, HPV-High Risk, cervical cancer, Federation of Gynecology and ObstetricsEpigenetic AlterationsWe observed that MEG3 was downregulated in cervical cancer tissues, compared to the adjacent normal tissues, and was negatively related with FIGO stages, tumor size, lymphatic metastasis, HR-HPV infection and the expression of homo sapiens microRNA-21 (miR-21).26574780
Autoimmune hepatitisEpigenetic AlterationsCirculating microRNA Profiles in Patients with Type-1 Autoimmune Hepatitis.26575387
Insemination, Artificial, HomologousEpigenetic AlterationsWe postulate that aberrantly expressed serum miRNAs are potential biomarkers of AIH and could be implicated in AIH pathogenesis.26575387
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is a frequent and early epigenetic event with potential application as a biomarker for cancer detection and an indicator of disease evolution.26575865
Malignant neoplasm of urinary bladderEpigenetic AlterationsThe reversibility of DNA methylation was examined by 5-Aza-CdR treatment in human bladder cancer cell lines.26575865
Stomach CarcinomaEpigenetic AlterationsThe expression patterns of miR-27b-3p and ROR1 in human gastric cancer (GC) specimens and cell lines were determined by microRNA RT-PCR and western blotting.26576539
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsMicroRNA molecular profiling from matched tumor and bio-fluids in bladder cancer.26576778
NeoplasmsEpigenetic AlterationsSignificant associations were noted between the log-adjusted average miRNA counts in tumor vs. WBCs (r = 0.418 p < 0.001), and tumor vs. urine (r = 0.38 p < 0.001).26576778
Malignant Neoplasms, Breast Carcinoma, Metastasis, NeoplasmsEpigenetic AlterationsHox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is pervasively overexpressed and correlated with tumor invasion, progression, metastasis, and poor prognosis in various human cancers including breast cancer (BC) that plays a role as an oncogenic molecule.26577852
Esophageal carcinomaEpigenetic AlterationsTreatment of esophageal cancer cells with demethylating agent 5-Aza-dC led to increased miR-203a and miR-203b expression, confirming the epigenetic regulation of both miRNAs.26577858
Esophageal carcinoma, NeoplasmsEpigenetic AlterationsThe inhibition of proliferation and invasiveness in esophageal cancer cells after treated with 5-Aza-dC or transfected with miR-203a or miR-203b mimics, suggesting the tumor suppressor role of both miRNAs in esophageal cancer.26577858
Squamous cell carcinoma of esophagusEpigenetic AlterationsIn summary, our results suggest that miR-203a and miR-203b may function as tumor-suppressive miRNAs that are inactivated through proximal promoter hypermethylation and miR-203a expression and methylation may be useful prognostic marker in ESCC patients.26577858
Breast CarcinomaEpigenetic AlterationsMicroRNA-Related DNA Repair/Cell-Cycle Genes Independently Associated With Relapse After Radiation Therapy for Early Breast Cancer.26581147
Breast CarcinomaEpigenetic AlterationsWe had previously identified microRNA-139-5p and microRNA-1274a as key regulators of breast cancer radiation response in vitro.26581147
Breast CarcinomaEpigenetic AlterationsAdditionally, independent publicly available mRNA/microRNA microarray expression datasets totaling >1000 early-stage breast cancer patients, treated with adjuvant radiation therapy, with >10 years of follow-up, were analyzed.26581147
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsLong noncoding RNA (lncRNA) NEAT1 has been reported to play critical roles in various human tumor entities and related to the survival of patients with malignancies.26582084
Intervertebral disc disorderEpigenetic AlterationsAccumulating evidence suggests that miRNAs play an important role in IDD, but the role of specific miRNAs involved in this disease remains elusive.26583473
Metastasis, Primary malignant neoplasmEpigenetic AlterationsMicroRNA-148a Suppresses Invasion and Metastasis of Human Non-Small-Cell Lung Cancer.26584284
Carcinogenesis, Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsGrowing evidence indicates that miRNAs are involved in carcinogenesis and tumor progression in non-small-cell lung cancer (NSCLC).26584284
Barrett EsophagusEpigenetic AlterationsProfiling of circulating microRNAs in patients with Barretts esophagus and esophageal adenocarcinoma.26585599
Glioblastoma Multiforme PathwayEpigenetic AlterationsIDH1 mutated paralimbic glioma shared many parameters with the purely insular glioma in respect to growth patterns, survival, and microRNA profile, but differed significantly from the IDH1 wild type paralimbic gliomas.26586262
Agenesis of corpus callosumEpigenetic AlterationsA comprehensive analysis of the different possible genetic and epigenetic mechanisms leading to TP53 alteration in ACC has never been reported and hence the role of TP53 in the pathogenesis and/or progression of ACC remains unclear.26586531
Intervertebral disc disorder, Intervertebral Disc DegenerationEpigenetic AlterationsIntervertebral disc degeneration (IDD) is associated with dysregulated expression of microRNAs (miRNAs).26587789
Intervertebral disc disorderEpigenetic AlterationsTherefore, we tested the hypothesis that miRNAs modulate IDD through effects on the IL-6/STAT3 signaling pathway, a potential regulator of IDD.26587789
Neoplasms, Neoplasm MetastasisEpigenetic AlterationsThe tumor suppressor p53 and the transcriptional repressor Enhancer of Zeste Homolog 2 (EZH2) have both been implicated in the regulation of epithelial-mesenchymal transition (EMT) and tumor metastasis via their impacts on microRNA expression.26587974
muscle cell differentiation, Antilymphocyte Serum, AtrophicEpigenetic AlterationsCirculating microRNAs as biomarkers of muscle differentiation and atrophy in ALS.26588026
CarcinomaEpigenetic AlterationsmiRNA expression profiles were compared between carcinoma cells, stromal cells and normal tissue samples.26590090
CarcinomaEpigenetic AlterationsA total of 43 miRNAs were found to be differentially expressed between carcinoma and stroma of which 11 belong to three miRNA families (miR-17, miR-15 and miR-515).26590090
CarcinomaEpigenetic AlterationsThe miRNA-mRNA mediated interactions between carcinoma and stromal cells add new knowledge regarding tumor-stroma interactions.26590090
AdenocarcinomaEpigenetic AlterationsDifferential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma.26590090
Periampullary carcinomaEpigenetic AlterationsWhereas miRNAs are known to regulate various cellular processes and interactions between cells, their exact role in periampullary carcinoma remains to be characterized, especially with respect to the prominent stromal component of pancreatobiliary type cancers.26590090
Pituitary AdenomaEpigenetic AlterationsOur results further support that epigenetic events are involved in the pathogenesis and biology of pituitary adenomas (PA).26593398
NeoplasmsEpigenetic AlterationsMicroRNAs have been integrated into tumorigenic programs as either oncogenes or tumor suppressor genes.26595523
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA-203 Is a Prognostic Indicator in Bladder Cancer and Enhances Chemosensitivity to Cisplatin via Apoptosis by Targeting Bcl-w and Survivin.26599571
Adenocarcinoma of lung (disorder)Epigenetic AlterationsGenome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis.26601720
Primary malignant neoplasmEpigenetic AlterationsDNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells.26601720
Carcinoma of lung, Adenocarcinoma of lung (disorder)Epigenetic AlterationsLung cancer patients have in general a poor prognosis, and a deeper insight into the epigenetic landscape in lung adenocarcinoma tumors and its prognostic implications is needed.26601720
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology, NeoplasmsEpigenetic AlterationsIncreasing evidence suggests that epigenetic regulation is responsible for tumor initiation and progression in head and neck squamous cell carcinoma (HNSCC).26604082
Malignant NeoplasmsEpigenetic AlterationsAlthough the polycomb group protein enhancer zeste homolog 2 (EZH2) is upregulated and a key epigenetic modifier implicated in various cancers, its molecular mechanism in HNSCC remains unknown.26604082
Stomach CarcinomaEpigenetic AlterationsA three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer.26607322
Stomach CarcinomaEpigenetic AlterationsMicroarray data showed that 25 miRNAs were upregulated in gastric cancer patients and 6 highly expressed miRNAs (miR-18a, miR-140-5p, miR-199a-3p, miR-627, miR-629 and miR-652) were selected for validation.26607322
Papillary thyroid carcinomaEpigenetic AlterationsDownregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance.26611646
Stomach CarcinomaEpigenetic AlterationsHowever, little is known about the interaction between miRNA and the Notch signalling pathway and its role in gastric cancer (GC).26612211
Hollings Cancer CenterEpigenetic AlterationsAbnormal miRNAs Targeting Chromosome Open Reading Frame Genes were Enriched in Microvesicles Derived from the Circulation of HCC.26615601
Hollings Cancer CenterEpigenetic AlterationsAs regulated by abnormal MVs miRNAs, functions of target Corf genes might be interrupted, which were much likely to contribute to HCC occurrence and progression.26615601
Rheumatoid ArthritisEpigenetic AlterationsIncreased expression of long noncoding RNAs LOC100652951 and LOC100506036 in T cells from patients with rheumatoid arthritis facilitates the inflammatory responses.26616293
Fibrosis AssessmentEpigenetic AlterationsMicroRNA expression profiling in peritoneal fibrosis.26616819
palladiumEpigenetic AlterationsAmong them, serum levels of miRNA-21-5p, miRNA-221-3p, and miRNA-327 and drained dialysate levels of miRNA-221-3p and miRNA-34a-5p were significantly correlated with peritoneal membrane functions in PD patients.26616819
FibrosisEpigenetic AlterationsAnti-miRNA-21-LNA significantly inhibited miRNA-21-5p expression in the PF mouse peritoneum, inhibited peritoneal fibrous thickening, and maintained peritoneal membrane functions.26616819
palladiumEpigenetic AlterationsThe expression levels of differentially expressed miRNAs were evaluated in serum and drained dialysate and associated with peritoneal membrane functions, as measured by the peritoneal equilibrium test in 33 PD patients.26616819
CarcinogenesisEpigenetic AlterationsTherefore, mechanistically this data reveals that epigenetic events, at least at the level of DNA methylation, modulate the functional outcome of common genetic mutations, such as Kras(G12D), during carcinogenesis.26617245
Carcinoma of lungEpigenetic AlterationsMicroRNA-299-3p promotes the sensibility of lung cancer to doxorubicin through directly targeting ABCE1.26617714
Loeys-Dietz SyndromeEpigenetic AlterationsLong noncoding RNA AK056155 involved in the development of Loeys-Dietz syndrome through AKT/PI3K signaling pathway.26617788
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs) play a significant role in cancer development and progression by regulating the expression of oncogenes or tumor suppressor genes.26617792
Malignant NeoplasmsEpigenetic AlterationsPyruvate kinase isozyme type M2 (PKM2), which is frequently up-regulated in multiple human malignancies, has been demonstrated to play a critical function in glucose metabolism, gene transcription and tumorigenesis.26617865
Squamous cell carcinoma, NeoplasmsEpigenetic AlterationsDecreased expression of microRNA-20a promotes tumor progression and predicts poor prognosis of cutaneous squamous cell carcinoma.26617873
Colorectal Cancer PathwayEpigenetic AlterationsAssociation of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer.26617875
CarcinomaEpigenetic AlterationsLong non-coding RNA (lncRNA) has an important role in carcinoma progression and prognosis.26617875
Liver carcinomaEpigenetic AlterationsLong non-coding RNA anti-differentiation ncRNA (lncRNA DANCR) was identified to be involved in carcinogenesis of hepatocellular carcinoma.26617879
Intervertebral Disc DegenerationEpigenetic AlterationsDownregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14.26620678
Intervertebral Disc DegenerationEpigenetic AlterationsIntervertebral disc degeneration (ICC)-specific miRNA profile generated by next generation sequencing.26620678
Intervertebral disc disorder, Intervertebral Disc DegenerationEpigenetic AlterationsAccumulating evidence suggests that microRNAs (miRNAs) play an important role in intervertebral disc degeneration (IDD), but the precise role of specific miRNAs involved in this disease remains elusive.26620678
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-20a in human faeces as a non-invasive biomarker for colorectal cancer.26621842
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsDetection of microRNA (miRNA) aberrations in human faeces is a new approach for colorectal cancer (CRC) screening.26621842
MIR20A geneEpigenetic AlterationsmiR-20a was selected from an expression microarray containing 667 miRNAs.26621842
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small non-coding RNA molecules, implicated in several activities like initiation, progression and prognosis of various cancers.26625766
Malignant Neoplasms, Squamous cell carcinomaEpigenetic AlterationsAberrant microRNA expression has been associated with the pathogenesis of a variety of human malignancies including oral squamous cell carcinoma (SCC).26625772
SERPINB3 wt AlleleEpigenetic AlterationsLow levels of miR-380-5p and miR-504 that directly target the 3UTR of TP53 suggest that p53 may not be repressed by these two miRNAs in OSCC.26625772
Carcinoma of lungEpigenetic AlterationsEvidence indicates that let-7 of microRNA may be a prognostic factor in lung cancer.26625972
Carcinoma of lungEpigenetic AlterationsGenetic variation in microRNA precursors could influence the processing and expression of microRNAs, which could affect the prognosis of lung cancer.26625972
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThis serum miRNA panel holds the potential for diagnosing ethnically diverse NSCLC patients.26629532
Primary malignant neoplasmEpigenetic AlterationsCirculating microRNAs (miRNAs) are promising biomarkers for cancer detection.26629532
OsteosarcomaEpigenetic AlterationsIncreasing evidence indicates that microRNAs (miRNAs) play critical roles in osteosarcoma (OS) occurrence and development.26631042
cervical cancerEpigenetic AlterationsMicroRNAs are important regulators of multiple cellular processes, and aberrant miRNA expression has been observed in human cervical cancer (CC).26631043
palladiumEpigenetic AlterationsFurthermore, the 4-miRNA panel enabled the differentiation of HY stage 1 and 2 PD patients from controls.26631297
Parkinson DiseaseEpigenetic AlterationsA panel of four decreased serum microRNAs as a novel biomarker for early Parkinsons disease.26631297
palladiumEpigenetic AlterationsSolexa sequencing technology and quantitative real-time PCR were applied to screen and verify altered serum miRNAs in PD patients.26631297
palladiumEpigenetic AlterationsThe four serum miRNAs may represent novel biomarkers for the early detection of PD.26631297
Malignant Ovarian Cyst, ovarian neoplasm, NeoplasmsEpigenetic AlterationsOvarian cancer (OV) is the most common and lethal gynecological tumor with a poor prognosis for women; however, the regulatory roles of the long non-coding RNAs (lncRNAs) in ovarian malignant progression are insufficiently understood.26631459
Parkinson DiseaseEpigenetic AlterationsIdentification of a panel of five serum miRNAs as a biomarker for Parkinsons disease.26631952
palladiumEpigenetic AlterationsThis group of five miRNAs can precisely distinguish PD patients from health individuals and may be used as a potential serum-based biomarker for the diagnosis of PD.26631952
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) are a class of small, noncoding RNA molecules involved in carcinogenesis.26632718
Non-Small Cell Lung CarcinomaEpigenetic AlterationsGenetic Variations in Key MicroRNAs are Associated With the Survival of Nonsmall Cell Lung Cancer.26632718
Primary malignant neoplasmEpigenetic AlterationsIt has been identified that genetic variations in miRNAs contribute to cancer risk, prognosis, and survival.26632718
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese findings indicated that genetic variations in miRNAs (miR-184, miR-218, and miR-124) might be prognostic markers for NSCLC patients.26632718
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-145 Modulates Tumor Sensitivity to Radiation in Prostate Cancer.26632856
Huntington DiseaseEpigenetic AlterationsMoreover, PRC2 repressive state was significantly depleted in HD-enriched peaks, suggesting the epigenetic role of PRC2 inhibition associated with up-regulated H3K4me3 in Huntingtons disease.26636336
Hollings Cancer Center, Primary malignant neoplasmEpigenetic AlterationsSerum expression of four miRNAs was assessed in 150 subjects (90 cases of HCC and 60 cases without cancer) by quantitative real-time polymerase chain reaction (qRT-PCR).26637228
Stomach CarcinomaEpigenetic AlterationsThe transcribed-ultraconserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation.26640143
Primary malignant neoplasmEpigenetic AlterationsMultiple sequential genetic and epigenetic alterations underlie cancer development and progression.26640145
LymphomaEpigenetic AlterationsThese results suggested that epigenetic silencing of miR-16 may be a key step during lymphoma development.26640145
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsAccumulated evidence indicates that microRNA (miRNA or miR) is involved in the development of type 2 diabetes (T2DM).26640407
Primary malignant neoplasmEpigenetic AlterationsGenome-Wide Analysis of Long Noncoding RNA Expression Profiles in Human Xuanwei Lung Cancer.26642714
Carcinoma of lungEpigenetic AlterationsLong noncoding RNAs (lncRNAs) play an important role in various biological processes involved the development and progression of lung cancer.26642714
Malignant Neoplasms, Colorectal Cancer Pathway, Clinical CoordinatorEpigenetic AlterationsDeregulated microRNA (miRNA) expression has been shown to be involved in the pathogenesis of several types of cancers including colorectal cancer (CRC).26643896
S100A4 protein, humanEpigenetic AlterationsThus, determining miRNA targets of genes that play critical role in the malignant transformation is very important.26643896
Colorectal CarcinomaEpigenetic AlterationsMTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations.26643896
NeoplasmsEpigenetic AlterationsHere, expression levels of tumor suppressor microtubule-associated tumor suppressor 1 (MTUS1) and its regulatory miRNAs were reported.26643896
Clinical CoordinatorEpigenetic AlterationsAccordingly, some of the overexpressed miRNAs especially the miR-135b-5p, -373-3p, 183-5p, 142-5p, 200c-3p, and 19a-3p may play key roles in CRC pathophysiology through MTUS1.26643896
Clinical Coordinator, NeoplasmsEpigenetic AlterationsIn conclusion, MTUS1 targeting miRNAs may play key roles in the development of CRC by downregulating tumor suppressor MTUS1.26643896
PathologyEpigenetic AlterationsEpigenetic mechanisms, such as DNA methylation, may be associated with aging processes and with modulation of the risk of various pathologies, such as DM.26643952
HyperglycemiaEpigenetic AlterationsWe identified an association between the TXNIP gene and DM through epigenetic mechanisms, related to sustained hyperglycemia levels (HbA1c >= 7%).26643952
Pancreatic carcinomaEpigenetic AlterationsMolecular subtypes of pancreatic cancer based on miRNA expression profiles have independent prognostic value.26644397
Coronary Artery DiseaseEpigenetic AlterationsWe profiled genes and miRNAs in perivascular EAT and subcutaneous adipose tissue (SAT) of metabolically healthy patients without coronary artery disease (CAD) vs. metabolic patients with CAD.26645979
EatingEpigenetic AlterationsCompared with SAT, a specific tuning of miRNAs and genes points to EAT as a tissue characterized by a metabolically active and pro-inflammatory profile.26645979
Clinical CoordinatorEpigenetic AlterationsThis novel approach allowed us to validate many previously published results using various techniques to profile miRNAs in CRC tissues or cell lines and to characterize true miRNA signatures highly expressed in colon/rectum (CR) or CRC tissues.26646696
Clinical CoordinatorEpigenetic AlterationsAccording to our results, miR-21, a miRNA that is up-regulated in CRC, and miR-143, a miRNA that is down-regulated in CRC, are the two miRNAs that dominated the miRNA population in CR tissues, and probably are also the most important miRNAs in CRCs.26646696
Primary malignant neoplasmEpigenetic AlterationsUsing TaqMan miRNA qPCR, we detected the relative expression of some of the CRC miRNAs in 10 CRC cell lines, validated their dysregulation under cancer condition, and provided possible explanation for their dysregulation, which could be caused by APC, KRAS, or TP53 mutations.26646696
Clinical CoordinatorEpigenetic AlterationsWe believe these results will provide a new direction in future miRNA-related CRC development studies, and application of miRNAs in CRC diagnosis/prognosis, and therapy.26646696
Colorectal CarcinomaEpigenetic AlterationsSignature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol.26646696
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsTo explore the role of miRNAs in colorectal cancers (CRC), we have deep sequenced 48 pairs of frozen CRC samples, of which 44 pairs produced high quality sequencing data.26646696
Breast Carcinoma, Mammary NeoplasmsEpigenetic AlterationsThis epigenetic silencing is also seen in human breast cancer cell lines and in a majority of human breast tumor tissues.26646903
Malignant NeoplasmsEpigenetic AlterationsThe epigenetic silencing of MORT in a large majority of the common human cancers suggests a potential fundamental role in cellular immortalization during human carcinogenesis.26646903
Prostate Cancer Pathway, MetastasisEpigenetic AlterationsMicroRNA-335 and -543 suppress bone metastasis in prostate cancer via targeting endothelial nitric oxide synthase.26647850
CHOANAL ATRESIA, POSTERIOR, Metastasis, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsEven though the regulatory role of microRNAs (miRNAs) in the control of tumor metastases has been well described in numerous types of cancer, the importance in bone metastasis of PCa remains largely unknown.26647850
Malignant tumor of colonEpigenetic AlterationsIdentifying molecular subtypes in human colon cancer using gene expression and DNA methylation microarray data.26647925
Renal Cell Carcinoma PathwayEpigenetic AlterationsMicroRNA-106b functions as an oncogene in renal cell carcinoma by affecting cell proliferation, migration and apoptosis.26648244
Breast Cancer CellEpigenetic AlterationsMicroRNA-106b (miR-106b) has been described as an oncogene in several types of human cancer.26648244
Metastasis, Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2.26648487
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNAs (miRs) have been found to play important roles in mediating a variety of biological processes in human cancers, including tumor cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT).26648487
ParagangliomaEpigenetic AlterationsEpigenetic Mutation of the Succinate Dehydrogenase C Promoter in a Patient With Two Paragangliomas.26652933
PGLS gene, Gastrointestinal Stromal Tumors, Carney TriadEpigenetic AlterationsThis report provides evidence that SDHC promoter methylation can cause PGLs due to SDHC inactivation, emphasizing the importance of considering epigenetic changes and functional readouts in the genetic evaluation of patients not only with GISTs and Carney triad but also with PPGL.26652933
Degenerative polyarthritisEpigenetic AlterationsElevated expression of microRNA-30b in osteoarthritis and its role in ERG regulation of chondrocyte.26653555
Refractory Cytopenia of ChildhoodEpigenetic AlterationsLogistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) for the association between DNA methylation level and the risk of RCC.26655847
Parkinson DiseaseEpigenetic AlterationsIncreased epigenetic age and granulocyte counts in the blood of Parkinsons disease patients.26655927
SF3B1 wt AlleleEpigenetic AlterationsThis study identifies microRNAs(miRNA) and miRNA targets that might represent leukemic transformation markers for MDS.26657287
Hepatitis B, Liver carcinomaEpigenetic AlterationsSera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.26660680
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsDNA methylation mainly affects tumor suppressor genes in the development of hepatocellular carcinoma (HCC).26660680
Hollings Cancer CenterEpigenetic AlterationsAberrant sera DNA methylation of CDH1, DNMT3b and ESR1 gene promoters could be a biomarker in the early diagnosis of HBV-related HCC.26660680
Primary malignant neoplasmEpigenetic AlterationsAccumulation of data indicates that misregulated long noncoding RNAs (lncRNAs) are implicated in cancer tumorigenesis and progression and might be served as diagnosis and prognosis biomarker or potential therapeutic targets.26662309
Breast CarcinomaEpigenetic AlterationsCirculating long noncoding RNA GAS5 as a potential biomarker in breast cancer for assessing the surgical effects.26662314
Malignant neoplasm of urinary bladderEpigenetic AlterationsPrognostic role of microRNA-100 in patients with bladder cancer.26662386
Pancreatic carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer.26662405
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsIt has been shown that microRNA-215 (miR-215) is dysregulated in several human malignancies, and this correlates with tumor progression.26662405
NeoplasmsEpigenetic AlterationsmicroRNA-218 (miR-218) is a vertebrate-specific miRNA that plays a crucial role in tumorigenesis and tumor progression.26662432
Pancreatic carcinomaEpigenetic AlterationsReduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosis.26662432
melanomaEpigenetic AlterationsExpression of microRNA-106b and its clinical significance in cutaneous melanoma.26662433
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-106b (miR-106b) is overexpressed in various types of cancers and is associated with the regulation of carcinogenic processes.26662433
Liver carcinomaEpigenetic AlterationsSystemic genome screening identifies the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma.26663434
Idiopathic Pulmonary FibrosisEpigenetic AlterationsSequence variation, methylation differences, and transcriptional changes in desmoplakin (DSP) have been observed in patients with idiopathic pulmonary fibrosis (IPF).26669357
Graft-vs-Host DiseaseEpigenetic AlterationsUsing genome-wide DNA methylation profiling, we showed that epigenetic signatures underlying aGVHD severity in recipients correspond to immune pathways relevant to aGVHD etiology.26669438
Graft-vs-Host DiseaseEpigenetic AlterationsWe discovered 31 DNA methylation marks in donors that associated with aGVHD severity status in recipients, and demonstrated strong predictive performance of these markers in internal cross-validation experiments (AUC = 0.98, 95% CI = 0.96-0.99).26669438
Acute GVH diseaseEpigenetic AlterationsA donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation.26669438
Degenerative polyarthritisEpigenetic AlterationsNo difference was observed for DNA methylation levels in the SMAD3 promoter region between OA cases and controls.26669923
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsOncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma.26670229
Gastric Gastrointestinal Stromal Tumor, CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in carcinogenesis, but the global miRNA expression profile in gastric stromal tumor tissues remains unclear.26670434
Gastric Gastrointestinal Stromal TumorEpigenetic AlterationsIt was concluded that gastric stromal tumor displays a unique miRNA signature.26670434
Gastric Gastrointestinal Stromal TumorEpigenetic AlterationsAltered expression profile of micrornas in gastric stromal tumor.26670434
Gastric Gastrointestinal Stromal TumorEpigenetic AlterationsThe dysregulated microRNAs were validated by quantitative RT-PCR in 30 pairs of gastric stromal tumor tissues.26670434
Gastric Gastrointestinal Stromal TumorEpigenetic AlterationsThe results showed that there were 12 differently expressed microRNAs in gastric stromal tumor tissues, among which 10 miRNAs were down-regulated, and 2 were up-regulated (P<0.05).26670434
Gastric Gastrointestinal Stromal TumorEpigenetic AlterationsmiR-3178 and miR-193a-5p function as suppressive microRNAs, and they may also become diagnosis and treatment targets for gastric stromal tumor.26670434
Asthma PathwayEpigenetic AlterationsOur goal was to determine whether DNA methylation was associated with predisposition to asthma and whether such a relationship was independent from genetic association.26671913
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHigh-throughput qRT-PCR validation of blood microRNAs in non-small cell lung cancer.26672767
Carcinoma of lung, Chronic Obstructive Airway DiseaseEpigenetic AlterationsMiRNAs that were identified as relevant for the separation between lung cancer and COPD by both qRT-PCR and the array-based studies included hsa-miR-26a-5p, hsa-miR-328-3p and hsa-miR-1224-3p.26672767
Primary malignant neoplasmEpigenetic AlterationsMethylation is a common epigenetic modification which may play a crucial role in cancer development.26674784
Subarachnoid Hemorrhage, AneurysmalEpigenetic AlterationsCirculating microRNA 132-3p and 324-3p Profiles in Patients after Acute Aneurysmal Subarachnoid Hemorrhage.26675167
Noninfiltrating Intraductal Carcinoma, S-AdenosylhomocysteineEpigenetic AlterationsHowever, there were no significant differences in fold changes between SAH patients with and without DCI [fold change ratios (mean+/-SD): 2.7+/-4.2 and 1.1+/-1.1 for miRNA-132 and miRNA-324].26675167
Noninfiltrating Intraductal Carcinoma, S-AdenosylhomocysteineEpigenetic AlterationsWe demonstrated that 99 miRNAs were found to be dysregulated in the SAH patient group with DCI.26675167
Liver carcinomaEpigenetic AlterationsUp-regulation of microRNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1.26676187
Squamous cell carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsTumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma.26676674
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsOur recent studies of microRNA (miRNA) expression signatures of human cancers showed that the microRNA-29 family (miR-29a, miR-29b and miR-29c) significantly reduced cancer tissues compared to normal tissues.26676674
Malignant Solid NeoplasmEpigenetic AlterationsLong non-coding RNA (lncRNA) is a variety of the human transcriptome that does not code for proteins and plays an important role in the development and progression of multiple solid malignant tumors.26676849
Malignant NeoplasmsEpigenetic AlterationsmiRNAs are currently considered to be important regulators for cell behavior and are deregulated in many malignancies.26676972
Childhood Leukemia, Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNA-9 promotes proliferation of leukemia cells in adult CD34-positive acute myeloid leukemia with normal karyotype by downregulation of Hes1.26678889
Mature B-Cell NeoplasmEpigenetic AlterationsGlobal measures of peripheral blood-derived DNA methylation as a risk factor in the development of mature B-cell neoplasms.26679037
Primary malignant neoplasmEpigenetic AlterationsPrevious research has shown that microRNA-141 (miR-141) expression levels are associated with survival in several types of cancer.26681225
TRPV6 geneEpigenetic AlterationsThese results suggest that the DNA methylation status of the TSDR is an important hallmark to define this heterogeneous disease and to predict ATL patient prognosis.26681759
TRPV6 geneEpigenetic AlterationsHere, we focus on the functional and clinical relationship between the epigenetic pattern of the TSDR and ATL.26681759
TRPV6 geneEpigenetic AlterationsThus, the epigenetic analysis of the FOXP3 gene identified a distinct subtype with Treg properties in heterogeneous ATL.26681759
MIR21 gene, Heart DiseasesEpigenetic AlterationsMIR21 encodes a microRNA (miR-21) that has previously been shown to be associated with the development of heart disease.26681806
Heart failureEpigenetic AlterationsIdentification of cardiac-related circulating microRNA profile in human chronic heart failure.26683101
Chronic heart failureEpigenetic AlterationsDuring chronic heart failure, levels of circulating miRNAs endued with characteristics of diseased cells could be identified as biomarkers.26683101
Heart failureEpigenetic AlterationsFour cardiac fibroblast-derived miRNAs (miR-660-3p, miR-665, miR-1285-3p and miR-4491) were found significantly upregulated in heart and plasma during heart failure.26683101
Squamous cell carcinoma of esophagusEpigenetic AlterationsGenome-wide profiling of DNA methylation and gene expression in esophageal squamous cell carcinoma.26683359
Squamous cell carcinoma of esophagusEpigenetic AlterationsPrevious studies have suggested that DNA methylation involved in the development of ESCC.26683359
Carcinogenesis, Squamous cell carcinoma of esophagusEpigenetic AlterationsThe identification of whole-genome DNA methylation patterns and gene expression profiles in ESCC provides new insight into the carcinogenesis of ESCC and represents a promising avenue through which to investigate novel therapeutic targets.26683359
Islet Cell TumorEpigenetic AlterationsHigh Expression of MicroRNA-196a Indicates Poor Prognosis in Resected Pancreatic Neuroendocrine Tumor.26683934
Islet Cell Tumor, Well Differentiated Pancreatic Endocrine TumorEpigenetic AlterationsThere is limited data on miRNA expression in pancreatic neuroendocrine tumors (PanNETs).26683934
Well Differentiated Pancreatic Endocrine TumorEpigenetic AlterationsWhen PanNETs were stratified into high (n = 10) and low (n = 27) miRNA-196a expression groups, miRNA-196a-high PanNETs were significantly associated with advanced pathologic T stage (50.0% vs 7.4%), N stage (50.0% vs 3.7%), higher mitotic counts (60.0% vs 3.7%), and higher Ki-67-labeling indices (60.0% vs 22.2%).26683934
Well Differentiated Pancreatic Endocrine TumorEpigenetic AlterationsMiRNA-196a level may be a promising prognostic marker of recurrence in resected PanNETs, although further experimental investigation would be required.26683934
melanomaEpigenetic AlterationsInhibition of CCL2 and of the selected miRNAs restored both the cell apoptosis and the drug efficacy in resistant melanoma cells.26684239
melanomaEpigenetic AlterationsTherefore, CCL2 and miRNAs are potential prognostic factors and attractive targets for counteracting treatment resistance in metastatic melanoma.26684239
Malignant neoplasm of urinary bladder, Hereditary DiseasesEpigenetic AlterationsBladder cancer is a molecular disease driven by the accumulation of genetic, epigenetic, and environmental factors.26685928
Degenerative polyarthritisEpigenetic AlterationsThe microRNA-29 family in cartilage homeostasis and osteoarthritis.26687115
Degenerative polyarthritisEpigenetic AlterationsMicroRNAs have been shown to function in cartilage development and homeostasis, as well as in progression of osteoarthritis.26687115
Degenerative polyarthritisEpigenetic AlterationsThese data identify the miR-29 family as microRNAs acting across development and progression of OA.26687115
Anaplastic large B-cell lymphoma, Adenocarcinoma of lung (disorder)Epigenetic AlterationsMicroRNA 25, microRNA 145, and microRNA 210 as biomarkers for predicting the efficacy of maintenance treatment with pemetrexed in lung adenocarcinoma patients who are negative for epidermal growth factor receptor mutations or anaplastic lymphoma kinase translocations.26687391
NeoplasmsEpigenetic AlterationsPhosphatase and tensin homolog (PTEN) and p16INK4a (p16) genes are tumor suppressor genes, associated with epigenetic alterations.26687648
Primary malignant neoplasmEpigenetic AlterationsPTEN and p16 promoter hypermethylation is a major epigenetic silencing mechanism leading to cancer.26687648
Primary malignant neoplasmEpigenetic AlterationsAssociation of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population.26688807
Neurocognitive DisordersEpigenetic AlterationsAccelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders.26689571
Neurocognitive DisordersEpigenetic AlterationsWhile these results suggest that the increased risk of a neurocognitive disorder due to HIV might be mediated by an epigenetic aging mechanism, future studies will be needed to validate the findings and dissect causal relationships and downstream effects.26689571
Neoplastic Syndromes, HereditaryEpigenetic AlterationsThis report highlights the role for BRCC3 in cardiovascular physiology and disease, and demonstrates that in some complex hereditary syndromes full diagnostics may require the examination of both genetic and epigenetic events.26691666
Esophageal carcinomaEpigenetic AlterationsResponse of esophageal cancer cells to epigenetic inhibitors is mediated via altered thioredoxin activity.26692290
Carcinoma of larynxEpigenetic AlterationsGlobal miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma.26694163
Primary malignant neoplasmEpigenetic AlterationsCirculating microRNAs (miRNAs) are potential noninvasive biomarkers for cancer detection.26695145
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIdentification of serum miRNAs by nano-quantum dots microarray as diagnostic biomarkers for early detection of non-small cell lung cancer.26695145
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe initially detected expression of 12 miRNAs using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) in preoperative serum samples of 94 NSCLC patients and 58 healthy controls.26695145
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe further validated our results using the fluorescence quantum dots liquid bead array for differentially expressed miRNAs in serum samples of 70 NSCLC patients and 54 healthy controls.26695145
Non-Small Cell Lung CarcinomaEpigenetic AlterationsA predictive model of miRNAs for NSCLC was derived by multivariate logistic regression.26695145
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe found that five serum miRNAs (miR-16-5p, miR-17b-5p, miR-19-3p, miR-20a-5p, and miR-92-3p) were significantly downregulated in NSCLC, while miR-15b-5p was significantly upregulated (p < 0.05).26695145
NeoplasmsEpigenetic AlterationsIn addition, the expression of serum miR-106-5p was higher in stage I than in stages IIa-IIIb, and no significant association was observed between expression of miRNAs and other variables including pathological type, tumor size, and lymph nodes status.26695145
Non-Small Cell Lung CarcinomaEpigenetic AlterationsSix serum miRNAs could potentially serve as noninvasive diagnostic biomarkers for resectable NSCLC.26695145
Sarcoidosis, PulmonaryEpigenetic AlterationsThere is limited information regarding the regulation of cytokine/chemokine-receptor network in bronchoalveolar lavage (BAL) cells in pulmonary sarcoidosis, suggesting contribution of miRNAs and transcription factors.26696750
Liver carcinomaEpigenetic AlterationsA possible role of microRNAs as predictive markers for the recurrence of hepatocellular carcinoma after liver transplantation.26697811
Neoplasms, Cessation of lifeEpigenetic AlterationsUsing the most significant miRNAs in this screening cohort, we could develop a predictive score, which combined the expression levels of miR-214, miR-3187 and the Milan criteria, and we could define low- and high-risk groups for tumour recurrence and death.26697811
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA-148a represents an independent prognostic marker in bladder cancer.26700670
Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsCirculating microRNA-203 predicts prognosis and metastasis in human colorectal cancer.26701878
Metastasis, Neoplasm MetastasisEpigenetic AlterationsIn spite of the important function of microRNA (miR)-203 in cancer metastasis, its clinical significance in CRC metastasis remains unknown.26701878
Malignant GliomaEpigenetic AlterationsMicroRNA-21 (miR-21) is the most consistently over-expressed microRNA (miRNA) in malignant gliomas.26701969
Neurodegenerative Disorders, Amyotrophic Lateral SclerosisEpigenetic AlterationsRecent evidence suggests that post-transcriptional regulation and epigenetic mechanisms, such as microRNAs, underlie the onset and progression of neurodegenerative disorders; therefore, altered microRNA expression may result in the dysregulation of key genes and biological pathways that contribute to the development of sporadic amyotrophic lateral sclerosis.26704906
Amyotrophic Lateral SclerosisEpigenetic AlterationsFurthermore, we report a global reduction of mature microRNAs, alterations in microRNA processing, and support for a role of the nucleotide binding protein, TAR DNA binding protein 43, in regulating sporadic amyotrophic lateral sclerosis-associated microRNAs, thereby offering a potential underlying mechanism for sporadic amyotrophic lateral sclerosis.26704906
Chronic Kidney DiseasesEpigenetic AlterationsRenal microRNA- and RNA-profiles in progressive chronic kidney disease.26707063
Chronic Kidney DiseasesEpigenetic AlterationsMicroRNAs (miRNAs) contribute to chronic kidney disease (CKD) progression via regulating mRNAs involved in renal homeostasis.26707063
Chronic Kidney DiseasesEpigenetic AlterationsThese results suggest the involvement of specific miRNAs and mRNAs in biological pathways associated with the progression of CKD.26707063
Liver carcinomaEpigenetic AlterationsDecreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by regulating vimentin.26707238
Liver carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-519a promotes tumor growth by targeting PTEN/PI3K/AKT signaling in hepatocellular carcinoma.26708293
Hollings Cancer CenterEpigenetic AlterationsPrevious miRNA array data showed that miR-519a was upregulated in HCC tissues compared to adjacent non-tumor tissues.26708293
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsMicroRNAs (miRNAs) have been found to play fundamental roles in the pathogenesis of hepatocellular carcinoma (HCC).26708293
Neoplasms, Renal Cell Carcinoma PathwayEpigenetic AlterationsMicroRNA-20b-5p functions as a tumor suppressor in renal cell carcinoma by regulating cellular proliferation, migration and apoptosis.26708577
Primary malignant neoplasmEpigenetic AlterationsRecently, increasing evidence has suggested that microRNAs (miRNAs) are involved in the proliferation, invasion and apoptosis of various types of human cancer cells.26708577
Squamous cell carcinoma of esophagusEpigenetic AlterationsDiagnostic and predictive significance of serum microRNA-7 in esophageal squamous cell carcinoma.26708917
NeoplasmsEpigenetic AlterationsMicroRNA-7 has been reported to participate in tumorigenesis and progression by several signaling pathways in various tumors.26708917
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA (miRNA) expression profile analysis indicated that miR-205 was upregulated in bladder cancer tissue compared to healthy tissue.26715266
Breast CarcinomaEpigenetic AlterationsOur findings indicated increased frequency of hypermethylation of PTEN promoter in the studied patients and their relatives that could be considered as one of the epigenetic factors affecting the risk of breast cancer in Iranians.26715274
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-584-3p, a novel tumor suppressor and prognostic marker, reduces the migration and invasion of human glioma cells by targeting hypoxia-induced ROCK1.26715733
Glioma, NeoplasmsEpigenetic AlterationsHere, we report that microRNA-584-3p (miR-584-3p) is up-regulated in hypoxic glioma cells and in high-grade human glioma tumors (WHO grades III-IV) relative to normoxic cells and to low-grade tumors (WHO grades I-II), respectively.26715733
Liver diseases, Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsThe results provide evidence for identifying epigenetic factors of elivated ALT and may be useful for risk assessment and personalized medicine of liver diseases such as non-alcoholic fatty liver disease (NAFLD).26717317
Malignant neoplasm of breastEpigenetic AlterationsTaken together, these findings provide evidence that a miRNA expression signature can be developed to aid existing methods to determine the risk of recurrence for women with estrogen receptor positive breast cancers treated with endocrine therapy.26717565
Breast Carcinoma, Aggressive behavior, Primary malignant neoplasmEpigenetic AlterationsAltered expression of miRNAs has been observed in many types of cancer, including breast cancer, and shown to contribute to cancer growth, aggressiveness, and response to therapies.26717565
PITX2 geneEpigenetic AlterationsAdditional miRNAs were found to positively correlate with RS, including miR-377-5p, miR-633b, miR-548t and miR-3648.26717565
NeoplasmsEpigenetic AlterationsPathway analysis of putative and validated targets suggests that these miRNAs may have a diverse range of functions that may contribute to tumor recurrence.26717565
Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-b1.26717894
Neoplasm MetastasisEpigenetic AlterationsRecently, microRNAs (miRs) have been demonstrated to play important roles in the regulation of cancer metastasis.26717894
Cerebral Infarction, Diabetes MellitusEpigenetic AlterationsThe Expression of microRNA-223 and FAM5C in Cerebral Infarction Patients with Diabetes Mellitus.26717922
Neoplasms, Refractory Cytopenia of ChildhoodEpigenetic AlterationsAberrant expression of miRNA-130b has previously been reported in tumors, however, its role in RCC remains to be elucidated.26717956
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsDownregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A. MicroRNA-206 (miR-206) has been discovered to have anticancer properties in different tissues.26718123
Squamous cell carcinoma of esophagusEpigenetic AlterationsCRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer.26718216
Squamous cell carcinoma of esophagusEpigenetic AlterationsCRCT1 expression was inversely correlated with the levels of microRNA-520 g (miR-520 g) in ESCC tissues, and CRCT1 was identified as a direct target gene of miR-520 g in ESCC cells.26718216
Stomach CarcinomaEpigenetic AlterationsDifferential expression profiles of long non-coding RNAs reveal potential biomarkers for identification of human gastric cancer.26718650
Cardiovascular, Coronary Artery DiseaseEpigenetic AlterationsmiRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease.26720041
CardiovascularEpigenetic AlterationsElevated levels of miRNA-197 and miRNA-223 reliably predicted future cardiovascular death in the overall group (miRNA-197: hazard ratio (HR) 1.77 per one standard deviation (SD) increase (95% confidence interval (CI) 1.20; 2.60), p = 0.004, C-index 0.78; miRNA-223: HR 2.23 per one SD increase (1.20; 4.14), p = 0.011, C-index 0.80).26720041
CO-methylating acetyl-CoA synthase activityEpigenetic AlterationsIn ACS patients the prognostic power of both miRNAs was even higher (miRNA-197: HR 2.24 per one SD increase (1.25; 4.01), p = 0.006, C-index 0.89); miRA-223: HR 4.94 per one SD increase (1.42; 17.20), p = 0.012, C-index 0.89).26720041
CardiovascularEpigenetic AlterationsSerum-derived circulating miRNA-197 and miRNA-223 were identified as predictors for cardiovascular death in a large patient cohort with CAD.26720041
Coronary Artery Disease, Cardiovascular DiseasesEpigenetic AlterationsCirculating microRNAs (miRNAs) have been described as potential diagnostic biomarkers in cardiovascular disease and in particular, coronary artery disease (CAD).26720041
Fungal keratitisEpigenetic AlterationsHuman Corneal MicroRNA Expression Profile in Fungal Keratitis.26720440
Fungal keratitisEpigenetic AlterationsThis is, to our knowledge, the first report on comprehensive human corneal miRNA expression profile in fungal keratitis.26720440
Fungal keratitisEpigenetic AlterationsBy deep sequencing, 75 miRNAs were identified as differentially expressed with fold change greater than 2 and probability score greater than 0.9 in fungal keratitis corneas.26720440
Fungal keratitisEpigenetic AlterationsSeveral miRNAs with high expression in fungal keratitis point toward their potential role in regulation of pathogenesis.26720440
Liver carcinomaEpigenetic AlterationsMicroRNA-194 acts as a prognostic marker and inhibits proliferation in hepatocellular carcinoma by targeting MAP4K4.26722431
Primary malignant neoplasm, Hollings Cancer Center, Liver carcinomaEpigenetic AlterationsMicroRNAs (miRNAs) play a crucial role in cancer development and progression of hepatocellular carcinoma (HCC).26722431
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA UCA1 may be a novel diagnostic and predictive biomarker in plasma for early gastric cancer.26722487
NeoplasmsEpigenetic AlterationsMicroRNA (miR) has been known to be of unique expressional patterns in various tumors and may work as potential tumor markers for clinical use.26722506
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-203 (miRNA-203 or miR-203) has previously shown significant alteration in a number of cancers.26722525
Diabetic FootEpigenetic AlterationsQuantification of the differential expression levels of microRNA-203 in different degrees of diabetic foot.26722550
Diabetic foot ulcerEpigenetic AlterationsSkin-enriched microRNA-203 (miR-203) was readily detected in skin tissue samples, and, in contrast to normal skin tissue, samples from patient with diabetic foot ulcers significantly have a higher expression level in miR-203.26722550
Malignant NeoplasmsEpigenetic AlterationsAccumulating evidence suggests that polymorphisms of miRNAs were associated with the tumorigenesis of various cancers, including PTC.26722556
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA-542-3p suppresses cellular proliferation of bladder cancer cells through post-transcriptionally regulating survivin.26723509
Rheumatoid ArthritisEpigenetic AlterationsmicroRNA-126 targeting PIK3R2 promotes rheumatoid arthritis synovial fibro-blasts proliferation and resistance to apoptosis by regulating PI3K/AKT pathway.26723864
Breast Carcinoma, HereditaryEpigenetic AlterationsRelationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer.26723934
Prostate Cancer PathwayEpigenetic AlterationsOverexpression of the Long Non-coding RNA SChLAP1 Independently Predicts Lethal Prostate Cancer.26724257
CHOANAL ATRESIA, POSTERIOR, Malignant neoplasm of prostateEpigenetic AlterationsThe long noncoding RNA SChLAP1 is overexpressed in a subset of prostate cancers (PCa), and high SChLAP1 expression by in situ hybridization (ISH) independently predicts biochemical recurrence after radical prostatectomy.26724257
Stomach CarcinomaEpigenetic AlterationsEpigenetic alterations of DNA mismatch repair (MMR) genes are associated with risk of gastric cancer (GC) by causing microsatellite instability (MSI).26724419
Chronic somatic dysfunction, Tubular atrophy, Interstitial Fibrosis AssessmentEpigenetic AlterationsAltered Expression of MicroRNAs Following Chronic Allograft Dysfunction with Interstitial Fibrosis and Tubular Atrophy.26725559
Sjogrens SyndromeEpigenetic AlterationsDefective DNA methylation in salivary gland epithelial acini from patients with Sjogrens syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration.26725749
Sjogrens Syndrome", Perceived stress scaleEpigenetic AlterationsThe pathogenesis of primary Sjogrens syndrome (pSS) is complex, in part due to DNA methylation abnormalities.26725749
Perceived stress scaleEpigenetic AlterationsIn conclusion, our results highlight the importance of DNA methylation in the pathophysiology of pSS and to the emergence of anti-SSB/La Ab.26725749
NeoplasmsEpigenetic AlterationsIllumina high-throughput sequencing was used to obtain miRNA expression profiles of paired tumor and adjacent normal tissues from one patient received TAI 1 week before the operation and another patient directly underwent an operation.26728674
melanomaEpigenetic AlterationsMicroRNA-21 expression and its pathogenetic significance in cutaneous melanoma.26731559
melanomaEpigenetic AlterationsWe previously reported that microRNA-21 (miR-21) was strongly expressed in melanoma relative to naevi and now sought to further assess the significance of this by assessing its relationship with its putative target, PTEN.26731559
ovarian neoplasmEpigenetic AlterationsWhat is more, aberrant expression of microRNA-21 (miR-21) has been shown to be involved in oncogenesis, but the relationship between miR-21 and HE4 in ovarian cancer is not clear.26733162
Ovarian CarcinomaEpigenetic AlterationsTaqMan((r)) MicroRNA (miRNA) assays were employed to detect the expression of miR-21 in the ovarian carcinoma.26733162
Choline Dehydrogenase, MitochondrialEpigenetic AlterationsDNA methylation has been posited as a mechanism linking psychological factors to CHD risk.26733571
Choline Dehydrogenase, MitochondrialEpigenetic AlterationsSuch epigenetic changes may represent biological pathways that mediate the effects of psychological factors on CHD.26733571
Breast CarcinomaEpigenetic AlterationsCirculating microRNA-based screening tool for breast cancer.26734993
Breast CarcinomaEpigenetic AlterationsHere, their plasmatic levels were measured to be used as an alternative screening procedure to mammography for breast cancer diagnosis.A plasma miRNA profile was determined by RT-qPCR in a cohort of 378 women.26734993
Malignant neoplasm of breast, NeoplasmsEpigenetic AlterationsA diagnostic model was designed based on the expression of 8 miRNAs measured first in a profiling cohort composed of 41 primary breast cancers and 45 controls, and further validated in diverse cohorts composed of 108 primary breast cancers, 88 controls, 35 breast cancers in remission, 31 metastatic breast cancers and 30 gynecologic tumors.A receiver operating characteristic curve derived from the 8-miRNA random forest based diagnostic tool exhibited an area under the curve of 0.81.26734993
Breast CarcinomaEpigenetic AlterationsThe miRNA signature correctly identified patients with metastatic breast cancer.26734993
Breast Carcinoma, PathologyEpigenetic AlterationsCirculating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer.26734993
Malignant neoplasm of breast, Breast Carcinoma, Malignant Female Reproductive System NeoplasmEpigenetic AlterationsThe use of the classification model on cohorts of patients with breast cancers in remission and with gynecologic cancers yielded prediction distributions similar to that of the control group.Using a multivariate supervised learning method and a set of 8 circulating miRNAs, we designed an accurate, minimally invasive screening tool for breast cancer.26734993
Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsDouble-strand break repair and colorectal cancer: gene variants within 3 UTRs and microRNAs binding as modulators of cancer risk and clinical outcome.26735576
Primary malignant neoplasmEpigenetic AlterationsInitially identified as a molecule that regulates the final step of glycolysis, the M2 isoform of pyruvate kinase (PKM2) was recently reported to have a central role in the metabolic reprogramming of cancer cells as well as participating in cell cycle progression and gene transcription.26739387
Colorectal Carcinoma, AdenomaEpigenetic AlterationsMicroRNA profiles in colorectal carcinomas, adenomas and normal colonic mucosa: variations in miRNA expression and disease progression.26740022
AdenomaEpigenetic AlterationsA total of 1893 carcinoma/normal-paired samples and 290 adenoma tissue samples were run on the Agilent Human miRNA Microarray V19.0 which contained 2006 miRNAs.26740022
Carcinoma, Colorectal Cancer Pathway, AdenomaEpigenetic AlterationsOur data suggest that miRNAs are highly dysregulated in colorectal tissue among individuals with colorectal cancer; the pattern of disruption varies by miRNA as tissue progresses from normal to adenoma to carcinoma.26740022
Carcinoma, AdenomaEpigenetic AlterationsRoughly half of these differentially expressed miRNAs showed a progression in levels of expression from normal to adenoma to carcinoma tissue.26740022
Carcinoma, AdenomaEpigenetic AlterationsOther miRNAs appeared to be altered at the normal to adenoma stage, while others were only altered at the adenoma to carcinoma stage or only at the normal to carcinoma stage.26740022
Impaired cognition, "Alzheimers Disease", Amnesia, CTCAEEpigenetic AlterationsDevelopment of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimers Disease and Amnesic Mild Cognitive Impairment.26742120
Carcinogenesis, Stomach CarcinomaEpigenetic AlterationsExpression of microRNAs (miRNAs) has been closely linked to the carcinogenesis of gastric cancer and has been considered as a powerful prognostic marker.26742429
melanomaEpigenetic AlterationsmicroRNA-10b is a prognostic biomarker for melanoma.26743475
melanomaEpigenetic AlterationsTaken together, these data suggest that miR-10b is a new prognostic microRNA for melanoma and that there could be a place for microRNA analysis in stratifying melanoma for therapy.26743475
melanomaEpigenetic AlterationsWe analyzed 377 microRNAs in 79 primary melanomas and 32 metastases using a split sample discovery strategy.26743475
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsFrom our results we conclude that miR-613 may act as a tumor suppressor in NSCLC and may serve as a tool for miRNA-based NSCLC therapy.26744345
Malignant Neoplasms, Non-Small Cell Lung CarcinomaEpigenetic AlterationsDeregulation of microRNAs (miRNAs) has been associated with a variety of cancers, including non-small cell lung cancer (NSCLC).26744345
Fibrosis AssessmentEpigenetic AlterationsEpigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.26744410
Degenerative polyarthritisEpigenetic AlterationsGenome-wide DNA methylation profile implicates potential cartilage regeneration at the late stage of knee osteoarthritis.26746145
Degenerative polyarthritisEpigenetic AlterationsOur data suggested the changes in DNA methylation occurred at the late stage of OA.26746145
NeoplasmsEpigenetic AlterationsCollectively, our work suggests EZH2 and its miRNA interactors may serve as promising biomarkers for progression of astrocytic tumors and may offer novel therapeutic strategies.26746204
NeoplasmsEpigenetic AlterationsInterestingly, EZH2 associated miRNAs were predicted to target 25 genes in glioma-pathway, suggesting their role in tumor formation or progression.26746204
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration.26750768
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsSingle-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) are considered potential markers of cancer risk and prognosis in various cancers.26753964
Pancreatic Ductal Adenocarcinoma, NeoplasmsEpigenetic AlterationsRASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression, chromosomal status and epigenetic changes.26754001
Squamous cell carcinoma of esophagusEpigenetic AlterationsPredictive value of plasma miRNA-718 for esophageal squamous cell carcinoma.26756617
Squamous cell carcinoma of esophagusEpigenetic AlterationsPlasma miRNA-718 expression level of ESCC patients was significantly lower than that of healthy controls.26756617
Tetranitromethane, MetastasisEpigenetic AlterationsPlasma miRNA-718 expression level was inversely correlated with the lymph node metastasis and TNM stage.26756617
Squamous cell carcinoma of esophagusEpigenetic AlterationsPlasma miRNA-718 is downregulated in ESCC patients and might serve as a potential diagnostic marker for ESCC.26756617
Malignant NeoplasmsEpigenetic AlterationsIncreasing evidence demonstrated that circulating miRNAs could serve as meaningfully non-invasive and reliable biomarkers for the detection of various cancers.26756617
OsteoporosisEpigenetic AlterationsOur data indicate that the food-derived compound SFN epigenetically stimulates osteoblast activity and diminishes osteoclast bone resorption, shifting the balance of bone homeostasis and favoring bone acquisition and/or mitigation of bone resorptionin vivo Thus, SFN is a member of a new class of epigenetic compounds that could be considered for novel strategies to counteract osteoporosis.26757819
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have been proved to play important roles in the tumorigenesis and development of human hepatocellular carcinoma (HCC).26758762
Glioblastoma Multiforme PathwayEpigenetic AlterationsInterplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion.26761212
Malignant GliomaEpigenetic AlterationsThe RNA-binding protein PCBP2, an oncogenic protein in human malignant gliomas, is an essential regulator of mRNA and miRNA biogenesis, stability and activity.26761212
ArteriosclerosisEpigenetic AlterationsHistone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques.26764138
atheroscleroticEpigenetic AlterationsHistone acetylation/methylation in the cells within atherosclerotic plaques was determined by immunohistochemistry.26764138
Atherosclerotic lesionEpigenetic AlterationsIncreased histone acetylation was observed on H3K9 and H3K27 in smooth muscle cells (SMCs) in advanced atherosclerotic lesions compared to healthy vessels (P=.002 and .034).26764138
ArteriosclerosisEpigenetic AlterationsHistone acetylation and methylation seem to play a decisive role in atherosclerosis, showing significant differences between healthy vessels and vessels at different stages of atherosclerosis.26764138
AMD1 wt AlleleEpigenetic AlterationsOur findings support the hypothesis that microRNA-mediated gene dysregulation may play a role in the pathogenesis of AMD.26765636
Primary malignant neoplasmEpigenetic AlterationsThe target genes of these miRNAs were enriched in pathways of cancer and MAPK signaling.26766035
PSD geneEpigenetic AlterationsBlood miRNAs may be served as a potential biomarker for PSD diagnosis.26766035
Aortic Aneurysm, AbdominalEpigenetic AlterationsHistone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm.26767057
Aortic Aneurysm, AbdominalEpigenetic AlterationsEpigenetic modifications may play a relevant role in the pathogenesis of human abdominal aortic aneurysm (AAA).26767057
Hemangioblastoma, CHEK2 geneEpigenetic AlterationsOur findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.26768750
levamisole, Uterine Corpus Endometrial Stromal Sarcoma, Childhood LeiomyosarcomaEpigenetic AlterationsTo compare the microRNA (miRNA) profiles of uterine endometrial stromal sarcoma (ESS) and leiomyosarcoma (LMS), and to compare the miRNA signatures of primary and metastatic uterine LMS.26768834
Leiomyosarcoma of uterus, Endometrial Stromal SarcomaEpigenetic AlterationsUterine leiomyosarcoma and endometrial stromal sarcoma have unique miRNA signatures.26768834
Malignant Neoplasms, levamisoleEpigenetic AlterationsDifferential miRNA signatures of ESS and LMS provide novel data regarding transcriptional regulation in these cancers, based on which new potential diagnostic markers, prognostic biomarkers and therapeutic targets may be explored.26768834
levamisole, Aggressive behaviorEpigenetic AlterationsDifferences in miRNA profiles of primary and metastatic LMS may improve our understanding of disease progression in this aggressive malignancy.26768834
levamisoleEpigenetic AlterationsNinety-four miRNAs were significantly differentially expressed in ESS and LMS, of which 76 were overexpressed in ESS and 18 overexpressed in LMS.26768834
levamisoleEpigenetic AlterationsForty-nine miRNAs were differentially expressed in primary and metastatic LMS, of which 45 were overexpressed in primary LMS and 4 in metastases.26768834
Leukemia, Myelomonocytic, ChronicEpigenetic AlterationsMutations involving epigenetic regulators (TET2~60% and ASXL1~40%) and splicing components (SRSF2~50%) are frequent in chronic myelomonocytic leukemia (CMML).26771811
Intraductal Hyperplasia, Neoplasms, FibroepithelialEpigenetic AlterationsGenetic and epigenetic alterations in genes associated with distinct cellular pathways were checked in fibroepithelial tumors, including fibroadenomas, benign and malignant phyllode and atypical ductal hyperplasia.26774289
Mammary NeoplasmsEpigenetic AlterationsAlterations (genetic/epigenetic) of the genes associated with Wnt signaling pathway were detected in 100% (20/20) of the breast tumors for at least one out of the six Wnt antagonists tested.26774289
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThe patterns of alterations, in particular the epigenetic alterations, differed little from that seen previously in breast carcinoma cells, suggesting epigenetic alterations to be an early event in the development of the tumors.26774289
Carcinoma, Transitional Cell, Malignant NeoplasmsEpigenetic AlterationsMicroRNA-30a as a prognostic factor in urothelial carcinoma of bladder inhibits cellular malignancy by antagonising Notch1.26775686
Hollings Cancer CenterEpigenetic AlterationsBoth miRNA expression levels were lower in HCC liver biopsy specimens compared with normal liver RNA.26776075
Chronic liver disease, Hollings Cancer CenterEpigenetic AlterationsFurthermore, expression of these miRNAs was compared between sera from chronic liver disease and sera from HCC patients.26776075
Chronic Lymphocytic LeukemiaEpigenetic AlterationsDNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.26780610
NeoplasmsEpigenetic AlterationsHowever, clonal tumor expansion from complex normal tissue architectures potentially obscures cancer-specific events, including divergent epigenetic patterns.26780610
Chronic Lymphocytic LeukemiaEpigenetic AlterationsEpigenetic maturation in CLL was associated with an indolent gene expression pattern and increasingly favorable clinical outcomes.26780610
Chronic Lymphocytic LeukemiaEpigenetic AlterationsInstead, we identified a potential pathogenic role for transcription factor dysregulation in CLL, where excess programming by EGR and NFAT with reduced EBF and AP-1 programming imbalances the normal B cell epigenetic program.26780610
Adenocarcinoma of lung (disorder)Epigenetic AlterationsTP53 and SOX2 were silenced using gene-specific siRNAs in human lung adenocarcinoma A427 cells, and the expression of TP53, SOX2 and subset of selected miRNAs was analyzed by qPCR.26780934
Aortic Aneurysm, AbdominalEpigenetic AlterationsClearance of matrix metalloproteinase-9 is dependent on low-density lipoprotein receptor-related protein-1 expression downregulated by microRNA-205 in human abdominal aortic aneurysm.26781079
Aortic Aneurysm, AbdominalEpigenetic AlterationsWe hypothesized that LRP1 downregulation may be mediated by microRNA (miR) and that LRP1 may function as a scavenger of matrix metalloproteinase-9 (MMP-9), a well-known protease for degradation of extracellular matrix proteins at the aortic wall for AAA pathogenesis.26781079
Transitional cell carcinoma of bladderEpigenetic AlterationsLong noncoding RNA HOTAIR is a prognostic biomarker and inhibits chemosensitivity to doxorubicin in bladder transitional cell carcinoma.26781446
Lynch SyndromeEpigenetic AlterationsAt least one-third of patients meeting clinical criteria for Lynch syndrome will have no germline mutation and constitutional epimutations leading to promoter methylation of MLH1 have been identified in a subset of these patients.26781822
Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-610 suppresses the proliferation of human glioblastoma cells by repressing CCND2 and AKT3.26782072
Glioblastoma MultiformeEpigenetic AlterationsHowever, the role of this microRNA in glioblastoma (GBM) is presently unclear.26782072
Rheumatoid ArthritisEpigenetic AlterationsCorrelation Between the Expression of MicroRNA-301a-3p and the Proportion of Th17 Cells in Patients with Rheumatoid Arthritis.26782362
Autoimmune DiseasesEpigenetic AlterationsMicroRNA (miR)-301a-3p is a regulatory factor for Th17 cells differentiation that contributes to the pathogenesis of autoimmune diseases.26782362
Squamous cell carcinoma of esophagusEpigenetic AlterationsClinical significance of microRNA-34a in esophageal squamous cell carcinoma.26782413
Squamous cell carcinoma of esophagusEpigenetic AlterationsMicroRNA-34a (miR-34a) has been found to be downregulated in esophageal squamous cell carcinoma (ESCC) tissues compared with that in normal tissues (P < 0.05), and miR-34a overexpression increased apoptosis and decreased clonogenic formation.26782413
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-494 (miR-494) expression is aberrant in various types of human cancer.26782462
SchizophreniaEpigenetic AlterationsAberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue.26784971
Neurodegenerative DisordersEpigenetic AlterationsThe DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set.26784972
NeoplasmsEpigenetic AlterationsSolid tumors are characterized by a plethora of epigenetic changes.26785262
Breast Cancer CellEpigenetic AlterationsUsing pharmacological unmasking microarray, we identified promoter DNA methylation of cysteine dioxygenase 1 (CDO1) gene in human cancer.26785325
Best Case Imputation TechniqueEpigenetic AlterationsPrognostic relevance of the CDO1 promoter DNA methylation is worthy of being paid attention in triple negative BC cancer.26785325
Malignant NeoplasmsEpigenetic AlterationsAberrant DNA methylation pattern is a common feature of most cancers.26786290
Stomach CarcinomaEpigenetic AlterationsGastric cancer (GC) is highly influenced by aberrant methylation, and accumulation of aberrant methylation in gastric mucosae produces an epigenetic field for cancerization.26792292
NeoplasmsEpigenetic AlterationsHere, we aimed to demonstrate that FAT4, a novel tumor suppressor identified by exome sequencing of GC, is methylation-silenced and that such methylation is involved in epigenetic field cancerization for GC.26792292
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAccumulating evidence indicates that dysregulated microRNA-146a (miR-146a) is involved in tumour genesis and cancer progression.26794279
Squamous cell carcinoma of esophagusEpigenetic AlterationsMicroRNA-146a expression level was significantly decreased in ESCC tissue compared with paracancerous tissue (P<0.001).26794279
Squamous cell carcinoma of esophagusEpigenetic AlterationsMicroRNA-146a is significantly reduced in cancerous tissue and serum samples of ESCC patients.26794279
Primary malignant neoplasmEpigenetic AlterationsThe methylation status was determined using Human Cancer miRNA EpiTect Methyl II Signature PCR Array(r) and the expression of miR-124, miR-218 and miR-193b was determined by qRT-PCR using individual TaqMan assays.26797462
CarcinogenesisEpigenetic AlterationsAbnormal expression and promoter methylation of microRNAs (miRNAs) are common events during cervical carcinogenesis.26797462
Communicable Diseases, precancerous lesions, cervical cancerEpigenetic AlterationsMethylation and expression of miRNAs in precancerous lesions and cervical cancer with HPV16 infection.26797462
Communicable Diseases, cervical cancerEpigenetic AlterationsIn this study we analyzed the promoter methylation of 22 miRNAs and the expression of three miRNAs in 10 non-squamous intraepithelial lesions (Non-SIL) without HPV16 infection, and 7 Non-SIL, 16 low-grade SIL (LSIL) and 16 cervical cancer samples, all with HPV16 infection.26797462
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsOverexpression of long non-coding RNA LOC400891 promotes tumor progression and poor prognosis in prostate cancer.26797783
Malignancy-associated membranous nephropathy, Primary malignant neoplasmEpigenetic AlterationsSeveral studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer biomarker has been identified to date.26798410
melanoma, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsWe analysed epigenome-wide DNA methylation profiles in 41 cancer discordant MZ twin-pairs with affected individuals diagnosed with tumours at different single primary sites: the breast, cervix, colon, endometrium, thyroid gland, skin (melanoma), ovary, and pancreas.26798410
Carotid Artery DiseasesEpigenetic AlterationsExpression of Egfl7 and miRNA-126-5p in Symptomatic Carotid Artery Disease.26799121
Cardiovascular DiseasesEpigenetic AlterationsSpecific information about miRNA-126-5p and its expression in cardiovascular disease is scarce in comparison to that of miR-126-3p.26799121
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe authors previously demonstrated that 4 hypoxia-mediated microRNAs (miRNA)-miR-210, miR-21, miR-10b, and miR-196b-are upregulated in glioma as compared with normal brain tissue.26799295
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsDynamics of circulating hypoxia-mediated miRNAs and tumor response in patients with high-grade glioma treated with bevacizumab.26799295
Stomach CarcinomaEpigenetic AlterationsEpigenetic Upregulation of Metallothionein 2A by Diallyl Trisulfide Enhances Chemosensitivity of Human Gastric Cancer Cells to Docetaxel Through Attenuating NF-kB Activation.26801633
Crohn DiseaseEpigenetic AlterationsMicroRNA-124 Promotes Intestinal Inflammation by Targeting Aryl Hydrocarbon Receptor in Crohns Disease.26802080
Disease, Crohn DiseaseEpigenetic AlterationsDysregulation of microRNAs (miRNAs) is associated with a variety of diseases, including Crohns disease (CD), but the essential biological functions and crucial targets of miRNAs remain largely unknown.26802080
Malignant NeoplasmsEpigenetic AlterationsAbnormal expression of microRNA-215 has been identified in a variety of solid cancers.26802165
Leukemia, Myelocytic, AcuteEpigenetic AlterationsHowever, little is known about the expression pattern of microRNA-215 in acute myeloid leukemia.26802165
Leukemia, Myelocytic, AcuteEpigenetic AlterationsCompared with the healthy individuals, microRNA-215 expression in acute myeloid leukemia patients was significantly down-regulated (P= 0.001).26802165
Non-M3 Acute Myeloid LeukemiaEpigenetic AlterationsMicroRNA-215 low-expressed patients had significantly shorter overall survival than microRNA-215 high-expressed patients in both non-M3 acute myeloid leukemia patients and cytogenetically normal patients (P= 0.017 and P= 0.044, respectively).26802165
Leukemia, Myelocytic, AcuteEpigenetic AlterationsOur study demonstrates that reduced microRNA-215 expression is a common event and is associated with poor clinical outcome in acute myeloid leukemia.26802165
Pelvic Organ ProlapseEpigenetic AlterationsMicroRNA-92 expression may be associated with reduced estrogen receptor b1 mRNA levels in cervical portion of uterosacral ligaments in women with pelvic organ prolapse.26803387
Alzheimers DiseaseEpigenetic AlterationsGenome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimers disease.26803900
Alzheimers DiseaseEpigenetic AlterationsWe have characterized changes in DNA methylation in the superior temporal gyrus of patients with Alzheimers disease, highlighting novel loci that facilitate better characterization of pathways and mechanisms underlying Alzheimers disease pathogenesis, and improve our understanding of epigenetic signatures that may contribute to the development of disease.26803900
Alzheimers DiseaseEpigenetic AlterationsRecent work has identified roles for environmental, genetic, and epigenetic factors in Alzheimers disease risk.26803900
Breast CarcinomaEpigenetic AlterationsDysregulation of microRNA contributes to the high incidence and mortality of breast cancer.26806308
Impaired cognition, Neuronal PlasticityEpigenetic AlterationsRecently, it has been reported that the microRNA-132(miR-132) is linked with synaptic plasticity and cognitive impairment.26806865
ETV3 wt AlleleEpigenetic AlterationsOur findings suggest that methylation in CPT1A is a promising epigenetic marker for MetS risk which could become useful as a treatment target in the future.26808626
Malignant neoplasm of breastEpigenetic AlterationsEpigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers.26810754
Breast CarcinomaEpigenetic AlterationsQuantitative real time PCR (qPCR) and immunoblotting were used to determine the impact of histone deacetylation and DNA methylation inhibitors on CREB3L1 expression in breast cancer cell lines.26810754
Breast CarcinomaEpigenetic AlterationsThis study demonstrates that the low CREB3L1 expression previously seen in highly metastatic breast cancer cell lines is caused in part by epigenetic silencing.26810754
Breast Carcinoma, MetastasisEpigenetic AlterationsOur data further strengthens the role for CREB3L1 as a metastasis suppressor in breast cancer and demonstrates that epigenetic silencing is a major regulator of the loss of CREB3L1 expression.26810754
NeoplasmsEpigenetic AlterationsHowever, there is a lack of information on how this epigenetic process differs in tumors originating at different sites in the stomach.26810771
Aggressive behaviorEpigenetic AlterationsMechanistic linkage of de-regulated miRNA/mRNA expressions provide new insights on their role in UM progression and aggressiveness.26812476
Uveal melanomaEpigenetic AlterationsClinico-Pathological Association of Delineated miRNAs in Uveal Melanoma with Monosomy 3/Disomy 3 Chromosomal Aberrations.26812476
Uveal melanomaEpigenetic AlterationsTo correlate the differentially expressed miRNAs with clinico-pathological features in uveal melanoma (UM) tumors harbouring chromosomal 3 aberrations among South Asian Indian cohort.26812476
Secondary malignant neoplasm of liverEpigenetic AlterationsmiRNAs predicting liver metastasis and survival have been identified.26812476
Malignant NeoplasmsEpigenetic AlterationsThe SWI/SNF chromatin remodeling complex is frequently inactivated by somatic mutations of its various components in various types of cancers, and also by aberrant DNA methylation.26812616
Squamous cell carcinoma of esophagusEpigenetic AlterationsThese results showed that genetic and epigenetic alterations of the SWI/SNF complex are present in ESCCs, and suggested that genetic alterations are induced at an early stage of esophageal squamous cell carcinogenesis.26812616
Malignant neoplasm of liver, Hepatitis C, ChronicEpigenetic AlterationsElevated serum microRNA-122/222 levels are potential diagnostic biomarkers in Egyptian patients with chronic hepatitis C but not hepatic cancer.26812693
Hepatitis C, Malignant neoplasm of liverEpigenetic AlterationsUsing microarray-based expression profiling followed by real-time quantitative polymerase chain reaction validation, we compared the levels of circulating miRNA-122 and miRNA-222 in serum from patients with hepatitis C virus (n = 40) and liver cancer (n = 60) to matched healthy controls (n = 30).26812693
Injury of liver, Hepatitis C, Malignant neoplasm of liverEpigenetic AlterationsBecause of their size, specificity, and relative stability in plasma, miRNAs can be used as diagnostic and prognostic biomarkers to monitor liver injury, such as that caused by hepatitis C virus (HCV) and liver cancer.26812693
Injury of liver, Malignant neoplasm of liverEpigenetic AlterationsOur results indicate that serum miR-122 and miR-222 are elevated in Egyptian patients with chronic HCV, and these miRNAs have a strong potential to serve as novel biomarkers for liver injury but not specifically for liver cancer.26812693
Gallbladder CarcinomaEpigenetic AlterationsExpression and mechanisms of long non-coding RNA genes MEG3 and ANRIL in gallbladder cancer.26812694
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsGenomic loss of EZH2 leads to epigenetic modifications and overexpression of the HOX gene clusters in myelodysplastic syndrome.26812882
SF3B1 wt AlleleEpigenetic AlterationsThese findings suggest genomic loss of EZH2 contributes to overexpression of the HOX gene clusters in MDS through epigenetic modifications.26812882
Malignant NeoplasmsEpigenetic AlterationsSingle nucleotide polymorphisms (SNPs) within microRNAs (miRNAs) are considered potential markers for risk and prognosis of various cancers.26815502
Asthma PathwayEpigenetic AlterationsSevere asthma AMs also expressed increased levels of three microRNAs, which we showed were able to directly reduce TLR7 expression.26815632
Hollings Cancer CenterEpigenetic AlterationsHere, we seek a more in-depth understanding of the roles of miRNAs and their targets in HCC by integrating the miRNA and messenger RNA (mRNA) expression profiles of tumorous and adjacent non-tumorous liver tissues of 100 HCC patients.26817861
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsTo date, studies of the roles of microRNAs (miRNAs) in hepatocellular carcinoma (HCC) have either focused on specific individual miRNAs and a small number of suspected targets or simply reported a list of differentially expressed miRNAs based on expression profiling.26817861
Liver carcinomaEpigenetic AlterationsDifferentially Expressed miRNAs in Hepatocellular Carcinoma Target Genes in the Genetic Information Processing and Metabolism Pathways.26817861
Hollings Cancer CenterEpigenetic AlterationsThree of these miRNAs (miR-26a, miR-122, and miR-130a) were down-regulated in HCC, and their up-regulated gene targets are primarily associated with aberrant cell proliferation that involves DNA replication, transcription and nucleotide metabolism.26817861
Hollings Cancer CenterEpigenetic AlterationsThe other three miRNAs (miR-21, miR-93, and miR-221) were up-regulated in HCC, and their down-regulated gene targets are primarily involved in metabolism and immune system processes.26817861
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAssociation between early promoter-specific DNA methylation changes and outcome in older acute myeloid leukemia patients.26818573
ibudilastEpigenetic AlterationsThe interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of IBD.26818663
NeoplasmsEpigenetic AlterationsAmong them, microRNAs (miRNA),identified as negative (post-transcriptional) gene expression regulators involved in tumor development, are likely to discriminate among FNs.26818914
Follicular neoplasmEpigenetic AlterationsThe evaluation of miRNAs on thyroid FNAC: the promising role of miR-375 in follicular neoplasms.26818914
AKAP13 wt AlleleEpigenetic AlterationsLBC is suitable for miRNAs evaluation.26818914
Malignant Neoplasms, Colorectal Cancer Pathway, Clinical Coordinator, NeoplasmsEpigenetic AlterationsAccumulating evidence showed that microRNA-152 (miR-152) was frequently downregulated, and functioned as tumor suppressor in many cancers, but little is known about its biological role and intrinsic regulatory mechanisms in colorectal cancer (CRC).26820128
Breast CarcinomaEpigenetic AlterationsA novel long non-coding RNA FGF14-AS2 is correlated with progression and prognosis in breast cancer.26820525
Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have been found to be pervasively transcribed in the genome and played critical roles in cancer progression.26820525
Hashimoto DiseaseEpigenetic AlterationsIncreases of microRNA let-7e in peripheral blood mononuclear cells in Hashimotos disease.26821743
ProstateEpigenetic AlterationsThe three variants are located within or near a number of prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2.26823525
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsEpigenetic associations of type 2 diabetes and BMI in an Arab population.26823690
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs) play essential roles in many tumors, including renal cell carcinoma (RCC).26823729
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsMDR1 gene could be activated via epigenetic mechanisms with demethylation of Line-1 in ESCC, and enhance tumor progression.26823755
Disease, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in many important cellular processes and deregulation of miRNAs is linked to many human diseases including cancer.26823812
Cervix DiseasesEpigenetic AlterationsThe current results indicated that MS-HRM-based testing for DNA methylations of MGMT plus DAPK1 genes holds some promise for high grade cervical disease screening.26823825
NeoplasmsEpigenetic AlterationsDNA methylation has been recently recognized as a novel tumor marker.26823831
Intestinal metaplasia, Dysplasia, Stomach Carcinoma, Gastritis, AtrophicEpigenetic AlterationsA total of 180 tissue and plasma samples (including 50 cases of gastric cancer, 50 dysplasia, 50 chronic atrophic gastritis with intestinal metaplasia and 30 normal controls) were collected for detecting DNA methylation status of Reprimo and hMLH1 genes using MSP method.26823831
Stomach Carcinoma, Dysplasia, GastritisEpigenetic AlterationsThe positive rate of DNA methylation rate was, in ascending sequence, gastritis tissue, dysplasia tissue and gastric carcinoma tissue.26823831
Depressed mood, Stomach Carcinoma, RPRM geneEpigenetic AlterationsThe DNA methylation occurred in promoter regions of both Reprimo and hMLH1 genes depressed the protein expression, and may participate in the occurrence and progression and gastric cancer.26823831
Stomach CarcinomaEpigenetic AlterationsThe combined assay of serum Reprimo and hMLH1 DNA methylation levels thus had critical importance in the early diagnosis and gastric cancer.26823831
MetastasisEpigenetic AlterationsDown-regulation of microRNA-126 and microRNA-133b acts as novel predictor biomarkers in progression and metastasis of non small cell lung cancer.26823832
Primary malignant neoplasmEpigenetic AlterationsMiRNAs play crucial roles in progression of cancer.26823832
Stomach CarcinomaEpigenetic AlterationsCorrelation between microRNA-421 expression level and prognosis of gastric cancer.26823855
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsThe expression of microRNA-421 (miR-421) is significantly elevated in gastric carcinoma cells, thus may play an important role in tumor occurrence.26823855
Diabetes MellitusEpigenetic AlterationsTobacco smoking is associated with DNA methylation of diabetes susceptibility genes.26825526
Diabetes MellitusEpigenetic AlterationsTobacco smoking, a risk factor for diabetes, is an established modifier of DNA methylation.26825526
Diabetes MellitusEpigenetic AlterationsWe hypothesised that tobacco smoking modifies DNA methylation of genes previously identified for diabetes.26825526
Diabetes MellitusEpigenetic AlterationsTobacco smoking is associated with differential DNA methylation of the diabetes risk genes ANPEP, KCNQ1 and ZMIZ1.26825526
Glioblastoma Multiforme PathwayEpigenetic AlterationsWe performed a high-throughput microarray to detect the ncRNA expression profiles of 220 human glioma tissues.26828136
Malignant Neoplasms, melanomaEpigenetic AlterationsTheir expression profiles are frequently dysregulated in cancers; hence, levels of serum microRNAs may reflect progression status and thus predict melanoma prognosis.26829037
DiscordanceEpigenetic AlterationsWe conclude that prenatal conditions for birth-weight discordance may result in persistent epigenetic modifications potentially affecting even adult health.26831219
Prostatic Hyperplasia, Tetranitromethane, Prostate Cancer PathwayEpigenetic AlterationsDifferential blood-based diagnosis between benign prostatic hyperplasia and prostate cancer: miRNA as source for biomarkers independent of PSA level, Gleason score, or TNM status.26831660
Prostate Cancer PathwayEpigenetic AlterationsThere is evidence that microRNAs (miRNAs) in whole peripheral blood can separate patients with localized prostate cancer from healthy individuals.26831660
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsBy microarray approach, we identified seven miRNAs that were significantly deregulated in PCa patients compared to BPH patients.26831660
TetranitromethaneEpigenetic AlterationsClinical parameters like PSA level, Gleason score, or TNM status seem to have only limited impact on the overall abundance of miRNAs in patients blood, suggesting a no influence of these factors on the expression of deregulated miRNAs.26831660
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsDNA methylation status defines clinicopathological parameters including survival for patients with clear cell renal cell carcinoma (ccRCC).26831665
NeoplasmsEpigenetic AlterationsDNA methylation classification of ccRCC tumor samples at diagnosis can serve as a clinically applicable prognostic marker in ccRCC.26831665
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, NeoplasmsEpigenetic AlterationsEpigenetic alterations in the methylome have been associated with tumor development and progression in renal cell carcinoma (RCC).26831665
Metastasis, Liver carcinomaEpigenetic AlterationsMicroRNA-7 downregulates the oncogene VDAC1 to influence hepatocellular carcinoma proliferation and metastasis.26831666
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAberrant DNA methylation status of some genes has been shown to be involved in chemoresistance of acute myeloid leukemia (AML).26835708
malignant disease, Stomach CarcinomaEpigenetic AlterationsGastric cancer (GC) is a common malignant disease and microRNAs (miRNAs) have been shown to play important roles in GC tumorigenesis.26835790
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsOur results suggest that MIR17HG gene expression is dysregulated in gastric cancer in which it may indicate a tumor suppressive function of this miRNA cluster host gene in gastric cancer.26837962
Relapsing course, Childhood LeukemiaEpigenetic AlterationsImpact of Global and Gene-Specific DNA Methylation in de Novo or Relapsed Acute Myeloid Leukemia Patients Treated with Decitabine.26838251
Degenerative polyarthritis, Right armEpigenetic AlterationsWe compared microRNA (miR) expression in CD14(+) cells from patients with active RA or with osteoarthritis (OA).26838552
NeoplasmsEpigenetic AlterationsmicroRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis.26840028
NeoplasmsEpigenetic AlterationsIn summary, our results reveal that miR-1827 is a novel miRNA that regulates p53 through targeting MDM2, and highlight an important role and the underlying mechanism of miR-1827 in tumor suppression.26840028
Carcinoma of lungEpigenetic AlterationsA Novel Epigenetic Signature for Early Diagnosis in Lung Cancer.26842235
Primary malignant neoplasmEpigenetic AlterationsWe aimed to identify epigenetic biomarkers with clinical utility for cancer diagnosis in minimally/noninvasive specimens to improve accuracy of current technologies.26842235
Lung NeoplasmsEpigenetic AlterationsThe identification of novel epigenetic biomarkers in stage I lung tumors was accomplished using an integrative genome-wide restrictive analysis of two different large public databases.26842235
Primary malignant neoplasmEpigenetic AlterationsCalibrated and cross-validated epigenetic model predicts with high accuracy the probability to detect cancer in minimally and noninvasive samples.26842235
Carcinoma of lungEpigenetic AlterationsWe demonstrated that this epigenetic signature achieved higher diagnostic efficacy in bronchial fluids as compared with conventional cytology for lung cancer diagnosis.26842235
Primary malignant neoplasmEpigenetic AlterationsMinimally invasive epigenetic biomarkers have emerged as promising tools for cancer diagnosis.26842235
Carcinoma of lungEpigenetic AlterationsThe herein obtained epigenetic model in combination with current diagnostic protocols may improve early diagnosis and outcome of lung cancer patients.26842235
Acute Coronary SyndromeEpigenetic AlterationsAssociation between microRNA-21 concentration and lipid profile in patients with acute coronary syndrome without persistent ST-segment elevation.26842377
Secondary malignant neoplasm of liver, Colorectal Carcinoma, NeoplasmsEpigenetic AlterationsMiRNA-21 Expression Decreases from Primary Tumors to Liver Metastases in Colorectal Carcinoma.26845148
Secondary malignant neoplasm of liver, Colorectal Cancer PathwayEpigenetic AlterationsWe analyzed the expression of miRNA-21, miRNA-31 and miRNA-373 in corresponding formalin-fixed paraffin-embedded (FFPE) tissue samples of primary colorectal cancer, liver metastasis and healthy tissues of 29 patients by quantitative real-time PCR.26845148
Secondary malignant neoplasm of liverEpigenetic AlterationsMiRNA-21 and miRNA-31 were also higher expressed in liver metastases as compared to healthy liver tissues (p < 0.01).26845148
Primary NeoplasmEpigenetic AlterationsNo significant difference of expression of miRNA-31 and miRNA-373 was observed between primary tumors and metastases.26845148
Secondary malignant neoplasm of liver, Colorectal NeoplasmsEpigenetic AlterationsOf note, miRNA-21 expression was significantly reduced in liver metastases as compared to the primary colorectal tumors (p < 0.01).26845148
Colorectal Cancer Pathway, Metastasis, NeoplasmsEpigenetic AlterationsExpression of certain miRNAs in the primary tumors has been shown to be associated with progression of colorectal cancer and the initiation of metastasis.26845148
NeoplasmsEpigenetic AlterationsAll three miRNAs were significantly up-regulated in the primary tumor tissues as compared to healthy colon mucosa of the respective patients (p < 0.01).26845148
Malignant neoplasm of endometriumEpigenetic AlterationsIdentification of microRNA expression profile related to lymph node status in women with early-stage grade 1-2 endometrial cancer.26847173
NeoplasmsEpigenetic AlterationsmicroRNA expression was assessed in nine formalin-fixed paraffin-embedded (FFPE) EC primary tumors with positive lymph node and in 27 FFPE EC primary tumors with negative lymph node, matched for grade, stage, and lymphovascular space involvement status.26847173
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsmicroRNA-137 (miR-137) has been reported as a tumor suppressor in various types of cancer.26847706
NeoplasmsEpigenetic AlterationsRecently, long non-coding RNAs (lncRNAs), which are non-protein coding transcripts longer than 200 nucleotides, have emerged as a key aspect in tumor pathogenesis.26847923
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small noncoding RNAs, which have been implicated in most human cancers due to their role in post transcriptional gene regulation.26848861
SF3B1 wt Allele, NeoplasmsEpigenetic AlterationsOur data indicate that spliceosome mutations may play an important role in MDS pathophysiology by affecting the expression of tumor suppressor miRNA genes involved in the development and progression of MDS.26848861
Neoplasms, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsTumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations.26848861
SF3B1 wt AlleleEpigenetic AlterationsThe majority of the studied miRNAs have previously been implicated in MDS.26848861
Leukemia, Myelocytic, AcuteEpigenetic AlterationsFinally, we observed that the predicted targets of the most downregulated miRNAs were involved in apoptosis, hematopoiesis, and acute myeloid leukemia among other cancer- and metabolic pathways.26848861
Primary malignant neoplasmEpigenetic AlterationsEnhancer of zeste homolog 2 (EZH2) is an essential component of the polycomb repressive complex 2 (PRC2), which is required for epigenetic silencing of target genes, including those affecting cancer progression.26848980
Metastasis, Adenocarcinoma of lung (disorder)Epigenetic AlterationsRIP and ChIP assays suggest that EZH2 is recruited to the E-cadherin promoter by the long non-coding RNA, MALAT-1 (metastasis associated in lung adenocarcinoma transcript 1), where it represses E-cadherin expression.26848980
Leukemia, T-CellEpigenetic AlterationsImpaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients.26849145
Feel PainEpigenetic AlterationsCorrelation Between DNA Methylation of TRPA1 and Chronic Pain States in Human Whole Blood Cells.26849948
Feel PainEpigenetic AlterationsThe presence of a burning sensation, which is one of pain symptoms in the DN4 questionnaire, was significantly correlated with the increase in DNA methylation level of TRPA1.26849948
Chronic pain, Feel PainEpigenetic AlterationsTRPA1 DNA methylation levels in whole blood cells appear to be associated with pain symptoms in chronic pain patients.26849948
HypoxiaEpigenetic AlterationsmicroRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction.26851030
Malignant neoplasm of cardioesophageal junction of stomachEpigenetic AlterationsHypoxia-regulated MicroRNAs in Gastroesophageal Cancer.26851030
Stomach Carcinoma, Metastasis, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs), a critical part of epigenetic regulations in tumor, have been shown to be closely related to the initiation, development, invasion, metastasis and prognosis of gastric cancer.26851540
Liver CirrhosisEpigenetic AlterationsHSA undergoes spontaneous structural modifications, mainly by reaction with oxidants and saccharides; however, patients with cirrhosis show extensive post-transcriptional changes at several molecular sites of HSA, the degree of which parallels the severity of the disease.26852162
DiseaseEpigenetic AlterationsMicroRNAs play important roles in the development and progression of many human diseases.26852168
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsGastric cancer (GC) is the third most common cancer in India and is mediated by multiple genetic, epigenetic and environmental risk factors.26853425
cervical cancer metastasisEpigenetic AlterationsHuman MALAT-1 long non-coding RNA is overexpressed in cervical cancer metastasis and promotes cell proliferation, invasion and migration.26854446
Malignant Neoplasms, Metastasis, Adenocarcinoma of lung (disorder), NeoplasmsEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been shown to play a crucial role in the development as well as the prognosis of various human cancers, particularly in human metastasis associated lung adenocarcinoma transcript-1 (MALAT-1), which has been shown to be upregulated in some tumors.26854446
Diffuse Large B-Cell LymphomaEpigenetic AlterationsWe conclude that miRNAs, in particular miR-34a, may have clinical utility in DLBCL patients as both predictive and prognostic biomarkers.26854484
Malignant Neoplasms, melanoma, NeoplasmsEpigenetic AlterationsStructural compromise of the tumor suppressor gene, phosphatase and tensin homolog (PTEN), occurs in 10% of melanoma specimens, and loss of PTEN expression through DNA methylation of the PTEN promoter region has also been reported in a number of other malignancies.26854490
Diabetes Mellitus, Insulin-DependentEpigenetic AlterationsDNA methylation and mRNA expression of HLA-DQA1 alleles in type 1 diabetes mellitus.26854762
Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8Epigenetic AlterationsMethylation profile observed in patients with T1D and healthy controls was similar, and no correlation between HLA-DQA1 allele expression and DNA methylation was found.26854762
Admitting diagnosisEpigenetic AlterationsmiR-603, a novel primate-specific miRNA and an intronic miRNA of a human brain highly expressed gene KIAA1217, is implicated in the risk and pathogenesis of AD.26856603
Admitting diagnosisEpigenetic AlterationsThis work suggests that miR-603 may be a novel AD-relevant miRNA and that its rs11014002 SNP may serve as a protective factor against AD.26856603
Sjogrens Syndrome", Autoimmune Diseases, Perceived stress scaleEpigenetic AlterationsIncreasing evidence suggests an epigenetic contribution to the pathogenesis of autoimmune diseases, including primary Sjogrens Syndrome (pSS).26857698
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsMicroRNA-194 is a Marker for Good Prognosis in Clear Cell Renal Cell Carcinoma.26860079
AneuploidyEpigenetic AlterationsWe conclude that the aneuploidy and senescence paradoxes can be explained by the mutual platform of polyploidy, conferring genomic and epigenetic instability as a survival advantage.26860864
Malignant neoplasm of urinary bladderEpigenetic AlterationsInhibiting malignant phenotypes of the bladder cancer cells by silencing long noncoding RNA SChLAP1.26861061
Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (lncRNAs) play key roles in process of cancer cell growth and apoptosis and have received increasing attention.26861061
Experimental Organism Basal Cell CarcinomaEpigenetic AlterationsLong-noncoding RNAs in basal cell carcinoma.26861560
MetastasisEpigenetic AlterationsMicroRNA-130b promotes proliferation and EMT-induced metastasis via PTEN/p-AKT/HIF-1a signaling.26861561
Neoplasm MetastasisEpigenetic AlterationsmiR-130b is one of several miRNAs involved in tumor metastasis.26861561
Degenerative polyarthritisEpigenetic AlterationsOverexpression of microRNA-210 promotes chondrocyte proliferation and extracellular matrix deposition by targeting HIF-3a in osteoarthritis.26861791
Stomach Carcinoma, MetastasisEpigenetic AlterationsLong noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer.26863570
Stomach Carcinoma, MetastasisEpigenetic AlterationsThe contribution of long noncoding RNAs (lncRNAs) to metastasis of gastric cancer remains largely unknown.26863570
Transitional cell carcinoma of ureterEpigenetic AlterationsUrothelial cancer associated 1 (UCA1) is an example of functional long noncoding RNAs involved in many biologic processes.26867765
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNA (lncRNA) HOX antisense intergenic RNA (HOTAIR) has recently emerged as a key molecule in many cancers, triggering epithelial-mesenchymal transition (EMT)-mediated cancer stem cell (CSC) formation, but little is known about its significance in EC.26868332
Carcinoma of lungEpigenetic AlterationsIntegrative microRNA and gene profiling data analysis reveals novel biomarkers and mechanisms for lung cancer.26870998
Non-Small Cell Lung CarcinomaEpigenetic AlterationsStudies on the accuracy of microRNAs (miRNAs) in diagnosing non-small cell lung cancer (NSCLC) have still controversial.26870998
Non-Small Cell Lung CarcinomaEpigenetic AlterationsTherefore, we conduct to systematically identify miRNAs related to NSCLC, and their target genes expression changes using microarray data sets.26870998
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe screened out five miRNAs and six genes microarray data sets that contained miRNAs and genes expression in NSCLC from Gene Expression Omnibus.26870998
Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur analysis results indicated that fourteen miRNAs were significantly dysregulated in NSCLC.26870998
seleniumEpigenetic AlterationsWe also found that 4 target genes (p < 0.05, fold change > 2.0) were significant correlation with the 14 discovered miRNAs, and the classifiers we built from one training set predicted the validation set with higher accuracy (SE = 0.987, SP = 0.824).26870998
Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur results demonstrate that integrating miRNAs and target genes are valuable for identifying promising biomarkers, and provided a new insight on underlying mechanism of NSCLC.26870998
Non-Small Cell Lung CarcinomaEpigenetic AlterationsFurther, our well-designed validation studies surely warrant the investigation of the role of target genes related to these 14 miRNAs in the prediction and development of NSCLC.26870998
Colorectal Cancer PathwayEpigenetic AlterationsThe relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway.26871294
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-31 (miR-31) plays an oncogenic role and is associated with BRAF mutation and poor prognosis in colorectal cancer.26871294
melanomaEpigenetic AlterationsA number of common driver mutations have been identified in melanoma, but other genetic or epigenetic aberrations are also likely to play a role in the pathogenesis of melanoma and present potential therapeutic targets.26872010
Primary malignant neoplasmEpigenetic AlterationsMore recently, it has been found that TGF-b1 acts through microRNAs to regulate their target genes to promote cancer progresses.26873488
Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsUnique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease.26875698
HepatocarcinogenesisEpigenetic AlterationsPatients with high serum AFP and high degree of ballooning showed accumulation of oxidative DNA damage that could be a seed of DNA methylation responsible for hepatocarcinogenesis.26875698
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsPreviously, we reported that DNA oxidation induced epigenetic alteration of tumor suppressor genes (TSGs) and contributed to HCC emergence.26875698
Acute myocardial infarctionEpigenetic AlterationsPlasma microRNA-21 is a potential diagnostic biomarker of acute myocardial infarction.26875904
liposarcomaEpigenetic AlterationsIn addition, a tight linear progression of miRNA expression was identified from normal fat to dedifferentiated liposarcoma.26878133
Sarcoma - category (morphologic abnormality)Epigenetic AlterationsThese results suggest that miRNA expression profiles could elucidate classes of miRNAs that may elicit tumor-relevant activities in specific sarcoma subtypes.26878133
SarcomaEpigenetic AlterationsA selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas.26878133
liposarcoma, synovial sarcoma, NeoplasmsEpigenetic AlterationsUnexpectedly, we found that a set of muscle-specific microRNAs (miRNAs; myomiRs): miR-133, miR-1, and miR-206 was significantly underexpressed in well-differentiated liposarcoma and synovial sarcoma, suggesting that they may function as tumor suppressors as described in muscle-relevant rhabdomyosarcomas.26878133
Malignant Neoplasms, Squamous cell carcinoma of esophagusEpigenetic AlterationsRecently, we have demonstrated that PIK3CA mutation and the methylation level of long interspersed nucleotide element 1 (LINE-1) (a surrogate marker of global DNA methylation level) are prognostic markers and have crucial role on malignancy in ESCC patients.26880326
Malignant Head and Neck NeoplasmEpigenetic AlterationsmicroRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer.26882562
Squamous cell carcinoma of the head and neckEpigenetic AlterationsTo identify microRNAs (miRNAs) that regulate HNSCC invasion, we compared miRNA expression profiles between a parent HNSCC cell line and a highly invasive clone.26882562
Liver carcinomaEpigenetic AlterationsGenome-wide DNA methylation analysis in hepatocellular carcinoma.26883180
Hollings Cancer CenterEpigenetic AlterationsOur results suggest that epigenetic silencing of these genes may be associated with HCC.26883180
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsLong noncoding RNA ENST00000434223 suppressed tumor progression in non-small cell lung cancer.26883250
Primary malignant neoplasmEpigenetic AlterationsEmerging evidence has demonstrated the vital roles of long noncoding RNAs (lncRNAs) in cancer development.26883250
Tuberculosis, Multidrug-ResistantEpigenetic AlterationsA total of 50 differentially expressed proteins and 43 differentially expressed miRNAs (fold change >1.50 or <0.60, P<0.05) were identified in the MDR-TB patients compared to both DS-TB patients and healthy controls.26884721
Breast CarcinomaEpigenetic AlterationsDNA methylation and hormone receptor status in breast cancer.26884818
Primary malignant neoplasmEpigenetic AlterationsClinical Impact of a Novel MicroRNA Chemo-Sensitivity Predictor in Gastrooesophageal Cancer.26885979
Gastrooesophageal cancerEpigenetic AlterationsThe miRNA profile predictive for sensitivity to cisplatin, epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer.26885979
Adrenal gland hypofunctionEpigenetic AlterationsHypofunctionality of NK cells was associated with impaired STAT4 phosphorylation and downregulation of the STAT4 target microRNA-155.26887815
Sleep Apnea, ObstructiveEpigenetic AlterationsWhole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.26888452
OSA protein, Drosophila, Hypertensive disease, daytime sleepiness, Sleep Apnea, Obstructive, Ehlers-Danlos SyndromeEpigenetic AlterationsWe hypothesized that DNA methylation patterns may contribute to disease severity or the development of hypertension and excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA).26888452
OSA protein, DrosophilaEpigenetic AlterationsIn the validation cohort, no significant difference in DNA methylation levels of six selected genes was found between the primary snoring subjects and OSA patients (primary outcome).26888452
Sjogrens SyndromeEpigenetic AlterationsAutoantigen-targeting microRNAs in Sjogrens syndrome.26888739
Sjogrens SyndromeEpigenetic AlterationsThis, on the one hand, characterized two autoantigen-targeting microRNAs in Sjogrens syndrome and, on the other hand, suggested that downregulation of miR-1207-5p and miR-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjogrens syndrome.26888739
CHOANAL ATRESIA, POSTERIOR, charmedEpigenetic AlterationsWe conclude that whole-genome methylation profiling with CHARM revealed distinct patterns of differential DNA methylation between normal prostate and PCa tissues, as well as between different risk groups of PCa as defined by Gleason scores.26890304
Juvenile Myelomonocytic LeukemiaEpigenetic AlterationsMethylation of a reporter construct containing this region resulted in strong suppression of AKAP12 promoter activity, suggesting that DNA methylation might be involved in the aberrant silencing of the AKAP12 promoter in JMML.26891149
Juvenile Myelomonocytic LeukemiaEpigenetic AlterationsEpigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia.26891149
Primary malignant neoplasmEpigenetic AlterationsEpigenetic silencing of AKAP12 has been demonstrated in different cancer entities and this has been linked to the process of tumorigenesis.26891149
Juvenile Myelomonocytic LeukemiaEpigenetic AlterationsTogether, these data provide evidence for epigenetic silencing of AKAP12a in JMML and further emphasize the importance of dysregulated RAS signaling in JMML pathogenesis.26891149
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsMicroRNAs (miRNAs) play vital roles in cell proliferation, differentiation and apoptosis in hepatocellular carcinoma (HCC).26891666
Non-Small Cell Lung CarcinomaEpigenetic AlterationsA genetic variation in microRNA target site of ETS2 is associated with clinical outcomes of paclitaxel-cisplatin chemotherapy in non-small cell lung cancer.26893365
GliomaEpigenetic AlterationsHULC long noncoding RNA silencing suppresses angiogenesis by regulating ESM-1 via the PI3K/Akt/mTOR signaling pathway in human gliomas.26894862
Malignant neoplasm of liver, GliomaEpigenetic AlterationsHighly upregulated in liver cancer (HULC) is a long noncoding RNA (lncRNA) that acts as an oncogene in gliomas.26894862
Malignant NeoplasmsEpigenetic AlterationsLong noncoding RNAs (lncRNAs) are associated with the development, progression, and prognosis of human cancers.26895099
Malignant NeoplasmsEpigenetic AlterationsMicro RNA (miR)-486-5p is often aberrantly expressed in human cancers.26895105
CarcinogenesisEpigenetic AlterationsCholine and betaine are important for DNA methylation and synthesis, and may affect tumor carcinogenesis.26897124
Breast Carcinoma, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsRoles of microRNA-124a and microRNA-30d in breast cancer patients with type 2 diabetes mellitus.26897751
Congenital AbnormalityEpigenetic AlterationsMutations of the epigenetic genes KMT2D and KDM6A cause dysregulation of certain developmental genes and account for the multiple congenital anomalies of the syndrome.26898171
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsmicroRNA-210 (miR-210), the master hypoxamir, is overexpressed and generally exhibits oncogenic properties in most human solid tumours, including colorectal cancer (CRC).26898324
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsMyelodysplastic syndromes (MDS) are driven by complex genetic and epigenetic alterations.26898884
Malignant neoplasm of stomach stage IVEpigenetic AlterationshTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a.26903137
ovarian neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in the pathogenesis of ovarian cancer.26908019
Primary malignant neoplasmEpigenetic AlterationsLong Noncoding RNA PVT1 Promotes Non-Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS2 Expression.26908628
Metastasis, Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (lncRNA) are a novel class of transcripts with no protein coding capacity, but with diverse functions in cancer cell proliferation, apoptosis, and metastasis.26908628
Metastasis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsExpression levels of microRNA-145 and microRNA-10b are associated with metastasis in non-small cell lung cancer.26909466
Metastasis, NeoplasmsEpigenetic AlterationsAccumulating evidence suggests that microRNAs (miRNAs) are key players in the regulation of tumor cell invasion and metastasis.26909466
Metastasis, Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsExpression of miR-9, miR-10b, miR-145, and miR-155, 4 miRNAs previously shown to play roles in metastasis in other tumor types, was compared in lymph node (LN)-positive NSCLC versus LN-negative NSCLC.26909466
Coronary Artery DiseaseEpigenetic AlterationsRecent studies have suggested that single-nucleotide polymorphisms (SNPs) in miRNA genes or their binding sites may alter an individuals susceptibility to coronary artery disease (CAD).26909569
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) act as key regulators of multiple cancers.26909600
Primary malignant neoplasmEpigenetic AlterationsThe long non-coding RNA MALAT-1 plays an important role in cancer prognosis.26909935
Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsThese findings suggest RUNX1high is a prognostic biomarker of unfavorable outcome in CN-AML, which is supported by the distinctive gene/microRNA signatures and cell signaling pathways.26910834
Cytogenetically normal acute myeloid leukemiaEpigenetic AlterationsSeveral known oncogenes/oncogenic microRNAs and cell signaling pathways were all up-regulated, while some anti-oncogenes and molecules of immune activation were down-regulated in RUNX1high CN-AML patients.26910834
Malignant NeoplasmsEpigenetic AlterationsAs an area of focus in the post-genome period, long non-coding RNAs (lncRNAs) have been found to play critical roles in many cancers, including TNBC.26910840
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-410 acts as oncogene in NSCLC through downregulating SLC34A2 via activating Wnt/b-catenin pathway.26910912
Gastric AdenocarcinomaEpigenetic AlterationsEnhanced expression of long non-coding RNA NEAT1 is associated with the progression of gastric adenocarcinomas.26911892
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) are emerging as new players in the cancer.26911892
Stomach CarcinomaEpigenetic AlterationsIncreased expression of long noncoding RNA TUG1 predicts a poor prognosis of gastric cancer and regulates cell proliferation by epigenetically silencing of p57.26913601
Primary malignant neoplasmEpigenetic AlterationsRecent evidence highlights long noncoding RNAs (lncRNAs) as crucial regulators of cancer biology that contribute to tumorigenesis.26913601
Inflammatory Breast CarcinomaEpigenetic AlterationsMicroRNA expression profiling identifies decreased expression of miR-205 in inflammatory breast cancer.26916073
Rectal NeoplasmsEpigenetic AlterationsA small-scale immunohistochemistry analysis showed coexistence of decreased microRNA-205 expression and decreased E-cadherin expression in some ductal tumors.26916073
Breast Carcinoma, Inflammatory Breast CarcinomaEpigenetic AlterationsMicroRNA-205 may serve as a therapeutic target in advanced breast cancer including inflammatory breast cancer.26916073
NeoplasmsEpigenetic AlterationsAlthough many microRNAs were differentially expressed between normal breast tissue and tumor tissue, most of them did not show differential expression between inflammatory and noninflammatory tumor samples.26916073
melanomaEpigenetic AlterationsmicroRNA in situ hybridization for miR-211 detection as an ancillary test in melanoma diagnosis.26916074
melanomaEpigenetic AlterationsThese results support miR-211 as a leading miRNA candidate for melanoma diagnosis and miRNA in situ hybridization as a uniquely uncomplicated ancillary test.26916074
Malignant neoplasm of urinary bladderEpigenetic AlterationsRecent advantages of serum miRNAs open a new realm of possibilities for non-invasive diagnosis and prognosis of bladder cancer (BC).26916216
Glioblastoma MultiformeEpigenetic AlterationsDecreased miRNA-146a in glioblastoma multiforme and regulation of cell proliferation and apoptosis by target Notch1.26916895
Hypertensive (finding), Heart DiseasesEpigenetic AlterationsEffect of Renal Sympathetic Denervation on Specific MicroRNAs as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease.26916982
Septicemia, Russell-Silver syndromeEpigenetic AlterationsSepsis eQTL were enriched in endotoxin-induced epigenetic marks and modulated the individual host response to sepsis, including effects specific to SRS group.26917434
T-Cell Prolymphocytic LeukemiaEpigenetic AlterationsGenes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia.26917488
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsWe aimed to identify early-phase circulating microRNAs after liver transplantation for predicting tumor recurrence and survival of HCC recipients.26918346
Hollings Cancer CenterEpigenetic AlterationsCandidate microRNAs were validated in 62 HCC recipients by quantitative RT-PCR.26918346
NeoplasmsEpigenetic AlterationsThe prognostic values of microRNAs for tumor recurrence and survival were examined.26918346
Reperfusion InjuryEpigenetic AlterationsSimulated in vitro ischemia-reperfusion injury models were employed to characterize the possible mechanism of up-regulation of circulating microRNAs.26918346
Liver carcinoma, NeoplasmsEpigenetic AlterationsEarly-phase circulating miRNAs predict tumor recurrence and survival of hepatocellular carcinoma patients after liver transplantation.26918346
GliomaEpigenetic AlterationsThe Potential Prognostic Value of MicroRNA-429 for Human Gliomas.26927341
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-429 (miR-429) is reported to be frequently dysregulated in cancer.26927341
Diabetic NephropathyEpigenetic AlterationsMicroRNAs (miRNAs) are short non-coding RNA species which are important post-transcriptional regulators of gene expression and play an important role in the pathogenesis of diabetic nephropathy.26930277
Diabetic NephropathyEpigenetic AlterationsUrinary Exosomal miRNA Signature in Type II Diabetic Nephropathy Patients.26930277
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsIn total, the expression of 16 miRNA species was deregulated (>2-fold) in DN patients compared to healthy donors and T2D patients: the expression of 14 miRNAs (miR-320c, miR-6068, miR-1234-5p, miR-6133, miR-4270, miR-4739, miR-371b-5p, miR-638, miR-572, miR-1227-5p, miR-6126, miR-1915-5p, miR-4778-5p and miR-2861) was up-regulated whereas the expression of 2 miRNAs (miR-30d-5p and miR-30e-5p) was down-regulated.26930277
MicroalbuminuriaEpigenetic AlterationsThe correlation of miRNA expression and micro-albuminuria levels could be replicated in a confirmation cohort.26930277
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsIn conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN.26930277
Kidney DiseasesEpigenetic AlterationsMost of the deregulated miRNAs are involved in progression of renal diseases.26930277
Stomach CarcinomaEpigenetic AlterationsLong Noncoding RNA H19-Derived miR-675 Enhances Proliferation and Invasion via RUNX1 in Gastric Cancer Cells.26931432
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsIdentification of a six microRNA signature as a novel potential prognostic biomarker in patients with head and neck squamous cell carcinoma.26933913
Primary malignant neoplasmEpigenetic AlterationsWe identified 19 miRNAs associated with over survival (OS) of patients with HNSCC in different clinical classes between 492 HNSCC tissues and 44 normal tissues from The Cancer Genome Atlas (TCGA) dataset.26933913
Colorectal Cancer PathwayEpigenetic AlterationsHigh blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2.26934556
Clinical CoordinatorEpigenetic AlterationsThe deregulation of microRNAs has been shown to be associated with the progression of CRC; however, the effects of high blood sugar levels on miR deregulation and, in turn, CRC remain unexplored.26934556
NeoplasmsEpigenetic AlterationsAbnormal expression of long non-coding RNAs (lncRNAs) have been shown to play an important role in tumor biology.26935047
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA-204 suppresses human non-small cell lung cancer by targeting ATF2.26935060
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) play a critical role in cancer development and progression.26935060
Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been reported to be dysregulated in cancer and to be important in the regulation of carcinogenesis, thus suggesting that this class of molecules may be used as biomarkers in cancer.26935146
Cervix carcinoma, MetastasisEpigenetic AlterationsMicroRNA-200b suppresses cell invasion and metastasis by inhibiting the epithelial-mesenchymal transition in cervical carcinoma.26935156
NeoplasmsEpigenetic AlterationsThe expression of microRNA (miR)-200b is suppressed in numerous tumor types, leading to epithelial-mesenchymal transition, which enables solid tissue epithelial cancers to invade and metastasize.26935156
Metastasis, Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsLong non-coding RNA-Low Expression in Tumor inhibits the invasion and metastasis of esophageal squamous cell carcinoma by regulating p53 expression.26935396
Chronic Obstructive Airway DiseaseEpigenetic AlterationsDifferential Expression of MicroRNAs in Chronic Obstructive Pulmonary Disease.26935494
Chronic Obstructive Airway DiseaseEpigenetic AlterationsThe miRNAs expressions in normal and COPD patients were found differentially.26935494
Colorectal Cancer PathwayEpigenetic AlterationsAberrant microRNA expression is common in colorectal cancer and DNA methylation is believed to be responsible for this alteration.26935905
Colorectal Cancer PathwayEpigenetic AlterationsEpigenetic silencing of miR-181b contributes to tumorigenicity in colorectal cancer by targeting RASSF1A.26935905
Colorectal Cancer PathwayEpigenetic AlterationsThis study indicated the clinical significance of miR-181b and the influence of miR-181b promoter region in epigenetic silencing of tumorigenicity in colorectal cancer, and implied the possible usage of miR-181b as a diagnostic and prognostic biomarker in colorectal cancer.26935905
Behavior, Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9.26936647
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miR)-133a expression has been reported to be downregulated in numerous human malignancies.26936647
Malignant ascitesEpigenetic AlterationsDiagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant, and malignant ascites.26937257
Primary malignant neoplasm, AscitesEpigenetic AlterationsAmong cancer patients, patients with DNA methylation-positive ascites showed an adverse clinical course (HR = 1.63, p = 0.039).26937257
AscitesEpigenetic AlterationsDNA methylation testing adds diagnostic and prognostic information and might constitute an effective ancillary method for the differential diagnosis of malignant, paramalignant, and benign ascites.26937257
Primary malignant neoplasmEpigenetic AlterationsMicroRNA Expression Profiling to Identify and Validate Reference Genes for the Relative Quantification of microRNA in Rectal Cancer.26937645
Primary malignant neoplasmEpigenetic AlterationsWe performed high-throughput miRNA profiling (OpenArray(r)) on ten pairs of laser micro-dissected rectal cancer tissue and adjacent stroma.26937645
Primary malignant neoplasmEpigenetic AlterationsIn the first validation experiment, a panel of miRNAs were analysed on 25 pairs of micro dissected rectal cancer tissue and adjacent stroma.26937645
Primary malignant neoplasmEpigenetic AlterationsSubsequently, the same miRNAs were analysed in 28 pairs of rectal cancer tissue and normal rectal mucosa.26937645
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsThe long noncoding RNAs (lncRNAs) have long been clarified to participate in hepatocellular carcinoma (HCC) as a biomarker.26938303
Kidney Failure, AcuteEpigenetic AlterationsPlasma microRNA-21 for the early prediction of acute kidney injury in patients undergoing major cardiac surgery.26940124
Kidney Failure, AcuteEpigenetic AlterationsMicroRNA-21 (miR-21) has been described as an early biomarker for AKI.26940124
Glioblastoma MultiformeEpigenetic AlterationsIntratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma.26940435
Malignant neoplasm of urinary bladderEpigenetic AlterationsLong non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis.26943042
Malignant NeoplasmsEpigenetic AlterationsUltraconserved regions (UCRs) have been shown to originate non-coding RNA transcripts (T-UCRs) that have different expression profiles and play functional roles in the pathophysiology of multiple cancers.26943042
Alzheimers DiseaseEpigenetic AlterationsCommon DNA methylation alterations of Alzheimers disease and aging in peripheral whole blood.26943045
NeoplasmsEpigenetic AlterationsIn conclusion, the increased levels of exosomal miR-200b and miR-200c mainly observed in advanced EOC suggest that these microRNAs may be involved in tumor progression.26943577
Hematologic Neoplasms, Childhood Leukemia, LymphomaEpigenetic AlterationsStrikingly, the up-regulated miRNAs are mostly associated with hematologic cancers, such as lymphoma, leukemia.26943588
Malignant Neoplasms, Liver carcinoma, Carcinoma of lungEpigenetic AlterationsAs a comparison, the up-regulated plasma miRNAs in middle-aged smokers are mostly associated with solid cancers, such as hepatocellular carcinoma and lung cancer, suggesting that smoking could have different influences on young adults and middle-aged adults.26943588
Malignant NeoplasmsEpigenetic AlterationsIn a conclusion, we identified the circulating miRNAs deregulated by cigarette smoking and revealed that the age-dependent deregulated miRNAs tend to be mainly involved in different types of human cancers.26943588
Admitting diagnosis, Frontotemporal dementiaEpigenetic AlterationsWe found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls.26944164
Hypertensive (finding)Epigenetic AlterationsPolymorphisms in the long non-coding RNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients.26944720
Esophageal carcinomaEpigenetic AlterationsSubsequently, aberrant DNA methylation of the miR-34a promoter was found in human esophageal cancer, and 5-AZA-dC inhibited DNA methylation of the miR-34a promoter.26944831
Subarachnoid HemorrhageEpigenetic AlterationsHuman cerebrospinal fluid microRNA: temporal changes following subarachnoid hemorrhage.26945012
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsmiRNAs are involved in liver regeneration, and their expression is dysregulated in hepatocellular carcinoma (HCC).26945106
Infection caused by Helicobacter pyloriEpigenetic AlterationsInteraction between inflammatory mediators and miRNAs in Helicobacter pylori infection.26945693
Infection caused by Helicobacter pyloriEpigenetic AlterationsOur results showed that H. pylori infection leads to up-regulation of TNFA, IL6, IL12A and IL2 and down-regulation of miRNAs.26945693
Delayed Release Dosage FormEpigenetic AlterationsSpecific miRNAs involved in DR development and/or progression can be used as molecular biomarkers, and based on these, for developing future biotherapies.26948458
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsGastric cancer (GC) is the fourth most prevalent type of cancer worldwide, which is usually caused by the interaction between environmental and genetic factors, or epigenetic aspects.26949090
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsReferring to the non-coding RNAs, miR-128b has been reported to be associated with many tumour cases, and exerts distinct functions in different types of cancers.26949090
Malignant NeoplasmsEpigenetic AlterationsAs one of the most widely studied epigenetic modifications, DNA methylation has an important influence on human traits and cancers.26949191
Malignant Childhood NeoplasmEpigenetic AlterationsDynamic variations in DNA methylation have been reported in malignant neoplasm and aging; however, the mechanisms remain poorly understood.26949191
Primary malignant neoplasmEpigenetic AlterationsBy constructing an age-associated and cancer-related weighted network (ACWN) based on the correlation of the methylation level and the protein-protein interaction, we found that DNA methylation changes associated with age were closely related to the occurrence of cancer.26949191
Primary malignant neoplasmEpigenetic AlterationsOur results will facilitate further studies regarding the impact of the epigenetic effects of aging on diseases and will aid in the development of tailored cancer preventive strategies.26949191
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsCirculating Long Noncoding RNA UCA1 as a Novel Biomarker of Acute Myocardial Infarction.26949706
Cardiovascular DiseasesEpigenetic AlterationsRecent studies have showed that long noncoding RNAs (lnc RNA) play important roles in pathophysiology of cardiovascular diseases, but the investigations are still in their infancy.26949706
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsTumor epigenetic defects are of increasing relevance to clinical practice, because they are druggable targets for cancer therapy using chromatin-remodeling agents (CRAs).26949823
Gastric AdenocarcinomaEpigenetic AlterationsGastric adenocarcinoma microRNA profiles in fixed tissue and in plasma reveal cancer-associated and Epstein-Barr virus-related expression patterns.26950485
Primary malignant neoplasmEpigenetic AlterationsMicroRNA expression in formalin-fixed paraffin-embedded tissue (FFPE) or plasma may add value for cancer management.26950485
Stomach CarcinomaEpigenetic AlterationsExpression of viral microRNAs in concert with unique human microRNAs provides novel insights into viral oncogenesis and reinforces the potential for microRNA profiles to aid in classifying gastric cancer subtypes.26950485
Virus DiseasesEpigenetic AlterationsEBV-infected versus uninfected cancers expressed multiple EBV-encoded microRNAs, and concomitant dysregulation of four human microRNAs suggests that viral infection may alter cellular biochemical pathways.26950485
Non-Cancer Related Death, Primary malignant neoplasmEpigenetic AlterationsHuman microRNAs were dysregulated between malignant and benign gastric mucosa and between plasma of cancer patients and non-cancer controls.26950485
Gastrointestinal Stromal TumorsEpigenetic AlterationsPIK3C2A is a gene-specific target of microRNA-518a-5p in imatinib mesylate-resistant gastrointestinal stromal tumor.26950487
Myeloid neoplasmEpigenetic AlterationsGenetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and prognosis.26950655
SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology, Leukemia, Myelocytic, AcuteEpigenetic AlterationsMyelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) share common features: elevated oxidative stress, DNA repair deficiency, and aberrant DNA methylation.26950655
ovarian neoplasmEpigenetic AlterationsmiRNA deregulation evinces a remarkable role in ovarian cancer tumorigenesis.26951510
Primary malignant neoplasmEpigenetic AlterationsmiRNA-199a (miR-199a) is known to be involved in cancer development and progression.26951510
Atrial FibrillationEpigenetic AlterationsAltered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery.26952538
Huntington DiseaseEpigenetic AlterationsDNA methylation profiling in human Huntingtons disease brain.26953320
Hodgkin Disease, Huntington DiseaseEpigenetic AlterationsDespite extensive progress in Huntingtons disease (HD) research, very little is known about the association of epigenetic variation and HD pathogenesis in human brain tissues.26953320
Breast Carcinoma, NeoplasmsEpigenetic AlterationsIt is suggested that miRNA may be a potential tumor marker for breast cancer.26957267
MIR21 gene, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival.26957558
MIR21 gene, NeoplasmsEpigenetic AlterationsPTGS2-driven inflammatory responses can induce tumor expression of microRNA MIR21 (miR-21) that can increase local PGE2 level by downregulating PGE2-metabolizing enzymes.26957558
Breast Carcinoma, NeoplasmsEpigenetic AlterationsTumor Evolution Inferred by Patterns of microRNA Expression through the Course of Disease, Therapy, and Recurrence in Breast Cancer.26957561
Breast CarcinomaEpigenetic AlterationsExploration of evolving disease by profiling 800 miRNA expression from serial samples of individual breast cancer patients at several time points: pretreatment, posttreatment, lymph nodes, and recurrence sites when available (58 unique samples from 19 patients).26957561
NeoplasmsEpigenetic AlterationsThese miRNAs were related to tumor proliferation and to the cell-cycle pathway, and their mRNA targets showed anticorrelated expression.26957561
MetastasisEpigenetic AlterationsInterestingly, the level of these miRNAs was lowest in matched recurrent samples from distant metastasis, indicating a gradual increase in proliferative potential through the course of disease.26957561
Thyroid NeoplasmEpigenetic AlterationsmiRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors.26960768
Carcinoma, Papillary, Papillary thyroid carcinomaEpigenetic AlterationsRelative expression of six microRNAs (miR-146b, -21, -221, -222, 375, -199b) appeared significantly different in BRAF(V600E)-positive samples (all classified as papillary thyroid carcinomas) compared to BRAF(V600E)-negative papillary carcinoma samples.26960768
Breast CarcinomaEpigenetic AlterationsMicroRNAs (miRs), short (20-25 nucleotides) non-coding RNAs, have been described as prognosticators and predictors for breast cancer in recent years.26962366
Breast Carcinoma, Fibrosis AssessmentEpigenetic AlterationsDNA methylation profiling of dermal fibroblasts obtained from breast cancer patients prior to irradiation identifies differences associated with fibrosis.26964756
DGKA gene, Fibrosis AssessmentEpigenetic AlterationsDecreased DNA methylation at this enhancer enables recruitment of the profibrotic transcription factor early growth response 1 (EGR1) and facilitates radiation-induced DGKA transcription in cells from patients later developing fibrosis.26964756
Fibrosis AssessmentEpigenetic AlterationsEpigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis.26964756
Fibrosis AssessmentEpigenetic AlterationsSince the molecular causes for fibrosis are largely unknown, we analyse if epigenetic regulation might explain inter-individual differences in fibrosis risk.26964756
NeoplasmsEpigenetic AlterationsIntervention of CUL4A(DCAF1) ubiquitin ligase complex led to fluctuation in expression levels of DICER1 and microRNAs, and thus affected tumor growth in a mouse xenograft model.26965998
Squamous cell carcinoma, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAlthough the importance of the epigenetic changes in tumors, including oral squamous cell carcinomas (OSCCs), is now becoming apparent, the mechanisms that trigger or cause aberrant DNA methylation in cancer are still unrevealed.26966018
SERPINB3 wt AlleleEpigenetic AlterationsDNMT gene expression could be a potential prognostic marker that might lead to an improvement in diagnosis, prognosis, and prospective use of epigenetic-targeted therapy of OSCC.26966018
Sjogrens Syndrome", FatigueEpigenetic AlterationsEpigenome-wide DNA methylation patterns associated with fatigue in primary Sjogrens syndrome.26966136
FatigueEpigenetic AlterationsRecent studies indicate that epigenetic mechanisms may be involved in the expression of fatigue, a prominent feature of primary SS (pSS).26966136
Neoplasm MetastasisEpigenetic AlterationsRecent evidence suggests that microRNAs (miRNAs) are involved in cancer metastasis and are promising therapeutic targets.26968949
SF3B1 wt AlleleEpigenetic AlterationsFurthermore, our previous work has identified a spectrum of innate immune genes in MDS CD34+ cells that are deregulated via abnormal promoter histone methylation.26970171
Admitting diagnosisEpigenetic AlterationsElevated miRNA-9 and miRNA-128a found in AD brain tissues might modulate the expression of ASS and NOS, respectively.26971935
Degenerative polyarthritisEpigenetic AlterationsOverexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1.26972586
Carcinoma of lung, Chronic diseaseEpigenetic AlterationsMicroRNAs play important roles in the development of human chronic diseases including lung cancer.26973201
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsWe hypothesize that circulating miRNA expression profiles vary according to differences in body mass index (BMI) and T2D and circulating miRNAs may reflect adipose tissue expression.26973292
Malignant NeoplasmsEpigenetic AlterationsThe epigenetic mark 5-hydroxymethylcytosine (5hmC) is reduced in various cancers, and this may involve reduced expression of the ten-eleven translocation 1 (TET1) enzyme.26973719
Pancreatic carcinomaEpigenetic AlterationsThe overexpression of microRNA-21 (miR-21) in pancreatic cancer has been implicated in drug resistance to gemcitabine.26977002
Peripheral Arterial DiseasesEpigenetic AlterationsSome emerging risk factors such as oxidative stress biomarkers and microRNAs (miRs) may add additional value to the established risk factors for peripheral artery disease (PAD).26980776
NeoplasmsEpigenetic AlterationsGenome-wide DNA methylation profiling of the tumor and matched non-cancerous mucosa was performed.26984265
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsThe different DNA methylation clusters of the tumors and normal tissue indicate that aberrant DNA methylation is a distinct feature of gastric cancer, although there is little difference in the overall, and low, methylation levels between the two tissue types.26984265
Stomach CarcinomaEpigenetic AlterationsA large number of epigenetic alterations has been found to be implicated in the etiology of gastric cancer.26984265
NeoplasmsEpigenetic AlterationsWe also observed a difference in the miRNA expression with respect to the histological type of the tumors.26984519
Breast CarcinomaEpigenetic AlterationsIn conclusion, our findings suggest that miRNA analysis of breast ductal fluid is feasible and potentially very useful for the detection of breast cancer.26984519
Breast CarcinomaEpigenetic AlterationsRecent studies suggest that microRNAs show promise as excellent biomarkers for breast cancer; however there is still a high degree of variability between studies making the findings difficult to interpret.26984519
Ductal Breast Carcinoma, NeoplasmsEpigenetic AlterationsWe identified 17 differentially expressed miRNAs between tumor and paired normal samples from patients with ductal breast carcinoma.26984519
Breast Carcinoma, Metastasis, Mammary NeoplasmsEpigenetic AlterationsMost of these miRNAs have various roles in breast cancer tumorigenesis, invasion and metastasis, therapeutic response, or are associated with several clinical and pathological characteristics of breast tumors.26984519
Breast Carcinoma, Milk, HumanEpigenetic AlterationsMoreover, some miRNAs were also detected in other biological fluids of breast cancer patients such as serum (miR-23b, -133b, -181a, 338-3p, -625), plasma (miR-200a), and breast milk (miR-181a).26984519
Hypertensive (finding)Epigenetic AlterationsComparative microRNA profiling in relation to urinary albumin excretion in newly diagnosed hypertensive patients.26984682
organic heart disease, Hypertensive diseaseEpigenetic AlterationsWe assessed the expression of the miRNAs miRNA-1, miRNA-133a, miRNA-26b, miRNA-208b, miRNA-499 and miRNA-21 in consecutive subjects with untreated newly diagnosed essential hypertension (aged 62.5+-9.7 years) and with no indications of other organic heart disease.26984682
Hypertensive diseaseEpigenetic AlterationsIn conclusion, miRNA-208b and miRNA-133a show distinct profiling in peripheral blood cells isolated from untreated patients with recently diagnosed essential hypertension.26984682
Chromosomal Instability, Brain Ependymoma, EpendymomaEpigenetic AlterationsDNA methylation profiling can distinguish 4 subgroups of intracranial ependymomas, including supratentorial (ST) ependymomas with Yes-associated protein 1 fusion (YAP1), ST ependymomas with fusion of v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), posterior fossa ependymomas with balanced genome, and posterior fossa ependymomas with chromosomal instability.26984744
Liver carcinomaEpigenetic AlterationsMicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a.26986232
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsAberrant microRNA (miRNA or miR) expression has been reported to contribute to the pathogenesis of hepatocellular carcinoma (HCC).26986232
Hollings Cancer CenterEpigenetic AlterationsHowever, the involvement of specific miRNAs in HCC remains to be elucidated.26986232
Malignant Neoplasms, Squamous cell carcinoma, SERPINB3 wt AlleleEpigenetic AlterationsAlthough microRNA-155 (miR-155) is known to play an important role in many cancers, its expression and function in oral squamous cell carcinoma (OSCC) was not fully understood.26986233
Squamous cell carcinoma of lungEpigenetic AlterationsEpigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients.26989022
NeoplasmsEpigenetic AlterationsIn conclusion, TMPRSS4 is a novel independent prognostic biomarker regulated by epigenetic changes in SCC and a potential therapeutic target in this tumor type, where targeted therapy is still underdeveloped.26989022
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsThe overall biological role and clinical significance of long non-coding RNA H19 in colorectal cancer (CRC) remain largely unknown.26989025
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsLong noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3.26989025
Prostate Cancer PathwayEpigenetic AlterationsDysregulation of miRNA has been implicated in the development and progression of prostate cancer.26990571
Prostate Cancer Pathway, MetastasisEpigenetic AlterationsThrough next generation miRNA sequencing, we recently identified a panel of five miRNAs associated with prostate cancer recurrence and metastasis.26990571
Prostate Cancer PathwayEpigenetic AlterationsOf the five miRNAs, miR-301a had the strongest association with prostate cancer recurrence.26990571
Clinical Coordinator, AdenomaEpigenetic AlterationsMicroRNAs profile in CSC-enriched colonic mucosal cells, expressed as ratio of high-risk (>=3 adenomas) to low-risk (no adenoma) CRC patients revealed an 8-fold increase in miR-1207-5p in AAs, compared to a 1.2-fold increase of the same in White people.26990997
Esophagitis, Pneumonitis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe genotyped 233 SNPs (161 in microRNA binding site and 72 in processing gene) and analyzed their associations with pneumonitis and esophagitis in 167 stage III NSCLC patients received definitive radiation therapy.26991123
Pneumonitis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur results provide strong evidence that microRNA-related genetic variations contribute to the development of radiotherapy-induced acute esophagitis and pneumonitis and could thus serve as biomarkers to help accurately predict radiotherapy-induced toxicity in NSCLC patients.26991123
Primary malignant neoplasmEpigenetic AlterationsIn many cancer types, the expression and function of ~22 nucleotide-long microRNAs (miRNA) is deregulated.26992225
Bone lesionEpigenetic AlterationsMicroRNAs have been reported to be involved in development of bone lesions in MM.26995755
Primary malignant neoplasmEpigenetic AlterationsDNA methylation in cancer has become the issue of passionate investigation.26997221
Traumatic injuryEpigenetic AlterationsGenome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans.26997371
Malignant Neoplasms, LymphomaEpigenetic AlterationsMicroRNA, which regulates gene expression, has critical functions in the growth and progression of many cancers and contributes to the pathogenesis of lymphoma.26997445
Malignant Neoplasms, Medial collateral ligamentEpigenetic AlterationsSeveral studies have revealed that microRNAs (miRs) from the miR-17-92 cluster are among the most deregulated miRNAs in human cancers, still little is known about this cluster in MCL.26998831
Malignant Neoplasms, CarcinogenesisEpigenetic AlterationsMicroRNA (miR)-503 is downregulated in several cancers and plays a tumor-suppressive role in carcinogenesis.26999740
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsmiRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer.26999740
Malignant neoplasm of larynxEpigenetic AlterationsSmall non-coding RNAs appear to be very promising biomarkers - and so remain the focus of extensive investigation in laryngeal cancer.27002759
Laryngeal Squamous Cell CarcinomaEpigenetic AlterationsNew miRNA expression abnormalities in laryngeal squamous cell carcinoma.27002759
DAB2IP gene, Carcinoma, Transitional CellEpigenetic AlterationsEpigenetic regulation of DAB2IP protein appears to play an important role in human urothelial carcinoma.27003158
Diabetes MellitusEpigenetic AlterationsVascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus.27005938
Ulcerative Colitis, Inflammatory Bowel Diseases, Clinical Coordinator, Crohn Disease, Colorectal Cancer Pathway, CDISC Integrated Basic Data Structure DatasetEpigenetic AlterationsEpigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohns disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC).27006956
Malignant Neoplasms, Stomach Carcinoma, NeoplasmsEpigenetic AlterationsThe oncogenic and tumor suppressor roles of miRNAs have been identified in cancers especially in gastric cancer, which is one of the most prevalent cancers.27007598
Stomach CarcinomaEpigenetic AlterationsCirculating MicroRNA-26a in Plasma and Its Potential Diagnostic Value in Gastric Cancer.27010210
NeoplasmsEpigenetic AlterationsFor classification, tumors were characterized by SDHA, B, C, or D (SDHX) mutations and other genetic and epigenetic alterations, including presence of mutations in germline.27011036
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-186 (miR-186) plays an important role in the pathogenesis of several cancers.27012040
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-134 modulates glioma cell U251 proliferation and invasion by targeting KRAS and suppressing the ERK pathway.27012554
Carcinogenesis, Glioblastoma Multiforme PathwayEpigenetic AlterationsDysregulated microRNA-134 (miR-134) has been observed in glioma carcinogenesis, and studies suggested that the ERK pathway plays vital roles in glioma cell growth and proliferation.27012554
Acute GVH disease, LymphomaEpigenetic AlterationsCirculating miRNA panel for prediction of acute graft-versus-host disease in lymphoma patients undergoing matched unrelated hematopoietic stem cell transplantation.27013207
Graft-vs-Host DiseaseEpigenetic AlterationsRemarkably, these upregulated microRNAs could be detected before the onset of aGVHD.27013207
Graft-vs-Host DiseaseEpigenetic AlterationsPathway prediction analysis indicated that these microRNAs may regulate critical pathways involved in aGVHD pathogenesis.27013207
Graft-vs-Host DiseaseEpigenetic AlterationsConsidering the noninvasive characteristics of plasma sampling and the feasibility of detecting miRNAs after allo-HSCT using real-time polymerase chain reaction, our results indicate that circulating microRNAs have the potential to enable an earlier aGVHD diagnosis and might assist in individualizing therapeutic strategies after MUD allo-HSCT.27013207
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAlthough microRNAs have been elaborated to participate in various physiological and pathological processes, their functions in TRAIL resistance of acute myeloid leukemia (AML) remain obscure.27013583
Stomach CarcinomaEpigenetic AlterationsMicroRNA-371-5p targets SOX2 in gastric cancer.27015119
Squamous cell carcinoma of esophagusEpigenetic AlterationsLong noncoding RNA MALAT1 promotes malignant development of esophageal squamous cell carcinoma by targeting b-catenin via Ezh2.27015363
DermatitisEpigenetic AlterationsWe conclude that this miRNA may serve as a mechanistic link between psoriatic skin inflammation and its systemic comorbidities.27015452
PsoriasisEpigenetic AlterationsMicroRNAs (miRNAs) are recently discovered gene regulators that play important roles in psoriasis skin inflammation.27015452
Malignant neoplasm of urinary bladderEpigenetic AlterationsshRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells.27015551
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsRecent reports show that long non-coding RNAs (lncRNAs) are emerging as significant functional regulators in the development of tumors, including bladder cancer.27015551
AMD1 wt Allele, Vitreous humorEpigenetic AlterationsMicroRNA signatures in vitreous humour and plasma of patients with exudative AMD.27015561
AMD1 wt AlleleEpigenetic AlterationsTo our knowledge, our study is the first to correlate vitreal and plasma miRNA signatures with NV AMD, highlighting potential future worth as biomarkers and providing insight on NV AMD pathogenesis.27015561
Irritable Bowel SyndromeEpigenetic AlterationsMicroRNA-199b expression level and coliform count in irritable bowel syndrome.27015896
Coliform bacteria, Irritable Bowel SyndromeEpigenetic AlterationsMoreover, there was a negative correlation between the count of Coliform and the serum miRNA-199b expression level in IBS.27015896
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are small noncoding RNAs involved in cancer development.27016415
Paget DiseaseEpigenetic AlterationsExtramammary Pagets disease (EMPD) is a rare cutaneous malignancy and the role of miRNAs in EMPD remains unknown.27016415
Prostate Cancer Pathway, Carcinogenesis, Prostatic Intraepithelial NeoplasiasEpigenetic AlterationsMicroRNA alteration and putative target genes in high-grade prostatic intraepithelial neoplasia and prostate cancer: STAT3 and ZEB1 are upregulated during prostate carcinogenesis.27017949
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsAmong them, 10 paired HGPIN and PCa were prepared to perform miRNA microarray and quantitative real-time PCR.27017949
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsEpigenetic regulation has been postulated to affect glucose metabolism, insulin sensitivity and the risk of type 2 diabetes.27019061
leukemia, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsRole of microRNA-29b in myelodysplastic syndromes during transformation to overt leukaemia.27020498
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsChromosome 7q32 is a frequently deleted region in myelodysplastic syndromes (MDSs) and encodes the microRNAs (miRNAs) miR-29a/miR-29b.27020498
Nasopharyngeal carcinoma, Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) play a critical role in cancer progression, including in nasopharyngeal carcinoma (NPC).27020592
Parkinson DiseaseEpigenetic AlterationsAltered Long Noncoding RNA Expression Precedes the Course of Parkinsons Disease-a Preliminary Report.27021022
Degenerative polyarthritisEpigenetic AlterationsLong Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage.27023358
Degenerative polyarthritisEpigenetic AlterationsMicroRNAs (miRNAs) are emerging as important regulators in osteoarthritis pathogenesis.27023516
Platelet aggregationEpigenetic AlterationsLower cg03548645 (TRAF3) DNA methylation levels were correlated with an increased platelet aggregation (r=-0.29, P=0.0075).27026631
Cerebrovascular accidentEpigenetic AlterationsThis study suggests for the first time that epigenetics may significantly contribute to the variability of clopidogrel response and recurrence of ischemic events in patients with stroke.27026631
Cerebrovascular accidentEpigenetic AlterationsTRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke.27026631
NCALD gene, Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsUpregulation of long intergenic noncoding RNA 00673 promotes tumor proliferation via LSD1 interaction and repression of NCALD in non-small-cell lung cancer.27027352
Metastasis, Primary malignant neoplasmEpigenetic AlterationsIn more recent years, mutiple lines of evidence have highlighted long noncoding RNAs (lncRNAs) serve as novel class of regulators of cancer biological processes, including proliferation, apoptosis and metastasis.27027352
Diabetes MellitusEpigenetic AlterationsBlood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes.27029739
Breast CarcinomaEpigenetic AlterationsGenetic and epigenetic factors affect RET gene expression in breast cancer cell lines and influence survival in patients.27034161
Breast CarcinomaEpigenetic AlterationsTumor-promoting function of single nucleotide polymorphism rs1836724 (C3388T) alters multiple potential legitimate microRNA binding sites at the 3-untranslated region of ErbB4 in breast cancer.27035115
Breast CarcinomaEpigenetic AlterationsBioinformatics analysis identified rs1836724 to be a polymorphism in the seed region of four miRNA binding sites (hsa-miR335-5p, hsa-miR-28-5p, has-miR-708-5p and has-miR-665), which may participate in the development of breast cancer.27035115
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1.27035227
Primary malignant neoplasmEpigenetic AlterationsThe expression of microRNA-335 (miR-335) has been demonstrated to be downregulated in numerous types of cancer.27035227
Esophageal carcinomaEpigenetic AlterationsExosome-shuttling microRNA-21 promotes cell migration and invasion-targeting PDCD4 in esophageal cancer.27035745
NeoplasmsEpigenetic AlterationsRecent evidence indicates that exosomes can mediate certain microRNAs (miRNAs) involved in a series of biological functions in tumor occurrence and development.27035745
Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-197 inhibits cell proliferation by targeting GAB2 in glioblastoma.27035789
Adenocarcinoma of lung (disorder)Epigenetic AlterationsIdentification of a three-miRNA signature as a blood-borne diagnostic marker for early diagnosis of lung adenocarcinoma.27036025
Adenocarcinoma of lung, stage IEpigenetic AlterationsTaken together, these findings suggest that the 3 miRNA-based biomarker might serve as a novel non-invasive approach for diagnosis of early-stage lung adenocarcinoma.27036025
Adenocarcinoma of lung, stage IEpigenetic AlterationsBased on the results from the screening and validation process, 3 miRNAs (miR-532, miR-628-3p and miR-425-3p) were found to display significantly different expression levels in early-stage lung adenocarcinoma, as compared to those in healthy controls.27036025
Carcinoma of lung, Adenocarcinoma of lung (disorder), Lung diseasesEpigenetic AlterationsImportantly, these three miRNAs could also distinguish lung adenocarcinoma from lung benigh diseases and other subtypes of lung cancer.27036025
Malignant Neoplasms, Magnetic-Targeted CarriersEpigenetic AlterationsWe focused our attention on the strongest up-regulated miRNA in MTC samples, miR-375, the deregulation of which has been previously observed in a variety of human malignancies including MTC.27036030
Primary malignant neoplasmEpigenetic AlterationsAs a mechanism underlying the reduced expression of NEIL1 in cancer, the epigenetic silencing of NEIL1 through promoter hypermethylation was found.27042257
Non-Small Cell Lung CarcinomaEpigenetic AlterationsNon-small cell lung cancer (NSCLC) is related to the genetic and epigenetic factors.27042875
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsMicroRNA-96 (miR-96) is an oncomiR that facilitates the development of malignant tumors by promoting growth, proliferation, and survival of cancer cells.27044381
ovarian neoplasm, NeoplasmsEpigenetic AlterationsMicroRNA-130b functions as a tumor suppressor by regulating RUNX3 in epithelial ovarian cancer.27048832
ovarian neoplasmEpigenetic AlterationsTo evaluate the clinical significance of microRNA (miR)-130b-Runt domain transcription factor (RUNX3) axis and its effects on oncogenic phenotypes of human epithelial ovarian cancer (EOC).27048832
ovarian neoplasmEpigenetic AlterationsMicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression.27049921
Cessation of lifeEpigenetic AlterationsFurthermore, these genotypes were significantly associated with reduced risk of overall death, death owing to disease, and recurrence after adjustment for important prognostic confounders, indicating that these pre-miRNA polymorphisms may be prognostic biomarkers for SCCNOP.27050146
Primary malignant neoplasmEpigenetic AlterationsFunctional polymorphisms of miRNAs may affect the function and target expression of miRNAs, which can, in turn, affect the biological activity, etiology, and prognosis of cancer.27050146
Autoimmune thrombocytopeniaEpigenetic AlterationsAberrant expression of long noncoding RNA TMEVPG1 in patients with primary immune thrombocytopenia.27050808
Autoimmune thrombocytopenia, Inosine TriphosphateEpigenetic AlterationsIt has been reported that plasma IFNG concentration was elevated and partly due to dysregulation of micro RNAs in patients with primary immune thrombocytopenia (ITP).27050808
Glioblastoma Multiforme PathwayEpigenetic AlterationsHere, we provide theoretical basis for glioma development and prognosis involving DNA-methylation driven silencing of SEMA3B, and thus, SEMA3B is a potential target for directed treatments against glioma.27050958
Primary malignant neoplasmEpigenetic AlterationsAlteration of Human Papillomavirus Type 16 Genetic and Epigenetic Profiles in Cervical Cancer Patients Is Indicative of Poor Disease Prognosis: A Cohort Analysis.27051049
Admitting diagnosisEpigenetic AlterationsDNA methylation, and particularly 5hmC, may be involved in regulating TREM2 mRNA expression in the AD brain.27051467
Stomach CarcinomaEpigenetic AlterationsSilence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer.27056384
Carcinoma, Transitional Cell, Malignant - descriptorEpigenetic AlterationsUrothelial carcinoma associated 1 (UCA1) gene is a long noncoding RNA (lncRNA), which shows expression and function abnormality in some kinds of malignant cancers.27056384
Liver carcinomaEpigenetic AlterationsMicroRNA-452 promotes stem-like cells of hepatocellular carcinoma by inhibiting Sox7 involving Wnt/b-catenin signaling pathway.27058905
GliomaEpigenetic AlterationsThe decrease of microRNA-452 (miR-452) in gliomas promoted stem-like features and tumorigenesis.27058905
Admitting diagnosisEpigenetic AlterationsWe examined the epigenetic regulatory mechanism of HMOX1 and its application as a diagnostic and prognostic biomarker for AD.27058954
Leukemia, Myelocytic, AcuteEpigenetic AlterationsHigh expression of p15 antisense RNA was frequently found among AML patients, and may play an important role in epigenetic silencing of p15.27060304
Alzheimers Disease", Neurotoxicity SyndromesEpigenetic Alterations5-Hydroxymethylation-associated epigenetic modifiers of Alzheimers disease modulate Tau-induced neurotoxicity.27060332
Admitting diagnosisEpigenetic AlterationsPathogenesis of AD is incompletely understood; evidence suggests a role for epigenetic regulation, in particular the cytosine modifications 5-methylcytosine and 5-hydroxymethylcytosine (5hmC).27060332
Admitting diagnosisEpigenetic AlterationsWe identified AD-associated single nucleotide polymorphisms (SNPs) located within or near DhMLs, suggesting these SNPs may identify regions of epigenetic gene regulation that play a role in AD pathogenesis.27060332
Primary malignant neoplasmEpigenetic AlterationsPolymorphisms in DNMT3B and MTHFR have been implicated in cancer etiology; however, it is increasingly clear that gene-specific DNA methylation also affects gene expression.27062459
Adenoma of large intestineEpigenetic AlterationsIn addition, increasing DNA methylation in the gene-coding area of DNMT3B was associated with higher risk of colorectal adenomas (OR = 1.34; 95% CI: 1.01-1.79 per SD).27062459
Adenoma of large intestineEpigenetic AlterationsGenetic and epigenetic variation in the DNMT3B and MTHFR genes and colorectal adenoma risk.27062459
Adenoma of large intestine, Colorectal Cancer Pathway, Clinical CoordinatorEpigenetic AlterationsThis research provides novel evidence that genetic and epigenetic variations contribute to colorectal adenoma risk, precursor to the majority of colorectal cancer (CRC).27062459
Diabetes MellitusEpigenetic AlterationsIn a third subsample (all with diabetes; n = 7 normal BMI + low insulin level, n = 9 normal BMI + high insulin level, n = 9 obese + high insulin level), we assessed DNA methylation.27062899
Diabetes MellitusEpigenetic AlterationsObserved differences in serum BDNF levels, genetic variants, and DNA methylation patterns across different glucose metabolic state suggest that BDNF may be involved in the pathophysiological process of insulin resistance and type 2 diabetes.27062899
melanoma, Malignant neoplasm of skinEpigenetic AlterationsWe further defined two other miRNA modulators of EMT (miR-191 and let-7a) in serum exosomes for differentiating stage I melanoma patients from non-melanoma subjects.27063098
Primary malignant neoplasmEpigenetic AlterationsMammalian microRNAs (miR) regulate the expression of genes relevant for the development of adaptive and innate immunity against cancer.27063186
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-1976 functions as a tumor suppressor and serves as a prognostic indicator in non-small cell lung cancer by directly targeting PLCE1.27063799
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHerein, we demonstrated that miR-1976 is a tumor-suppressor miRNA in NSCLC progression.27063799
HumorEpigenetic AlterationsMicroRNA Profiling in Aqueous Humor of Individual Human Eyes by Next-Generation Sequencing.27064390
HumorEpigenetic AlterationsThe authors adopted next-generation sequencing (NGS) techniques to further characterize the miRNA profile in single samples of 60 to 80 mL human aqueous humor.27064390
HumorEpigenetic AlterationsThe aqueous humor miRNA profile shows some overlap with published NGS-derived inventories of circulating miRNAs in blood plasma with high prevalence of human miR-451a, -21, and -16.27064390
Glaucoma, CTCAEEpigenetic AlterationsThe data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-b and Wnt, which are important in intraocular pressure regulation and glaucoma.27064390
HumorEpigenetic AlterationsExtracellular microRNAs (miRNAs) in aqueous humor were suggested to have a role in transcellular signaling and may serve as disease biomarkers.27064390
HumorEpigenetic AlterationsIn contrast to blood, miR-184, -4448, -30a, -29a, -29c, -19a, -30d, -205, -24, -22, and -3074 were detected among the 20 most prevalent miRNAs in aqueous humor.27064390
Malignant neoplasm of urinary bladderEpigenetic AlterationsDeregulation of seven CpG island-harboring miRNAs in bladder cancer: miR-155 and miR-23b as the most promising oncomiRs.27064870
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA SNHG5 suppresses gastric cancer progression by trapping MTA2 in the cytosol.27065326
Metastasis, Liver carcinomaEpigenetic AlterationsLong noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a.27065331
Squamous cell carcinomaEpigenetic AlterationsDespite there being over 35,000 different long noncoding RNA (lncRNA) sequences described little is known regarding their molecular-pathological role in cutaneous squamous cell carcinoma (cSCC).27067026
Squamous cell carcinoma of skinEpigenetic AlterationsExpression profiles of long noncoding RNAs in cutaneous squamous cell carcinoma.27067026
Mammary Neoplasms, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsWe determined the average departure of tumor DNA methylation from adjacent normal breast DNA methylation using Illumina 450K methylation data from 700 invasive breast tumors and 90 adjacent normal breast tissues in The Cancer Genome Atlas.27070496
NeoplasmsEpigenetic AlterationsFrom this we generated a novel summary measure of altered DNA methylation, the DNA methylation dysregulation index (MDI), and examined the relation of MDI with tumor characteristics and summary measures that quantify cumulative burden of genetic mutation and copy number alterations.27070496
Breast Carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma.27070496
NeoplasmsEpigenetic AlterationsA recursively partitioned mixture model of all 3 somatic alteration burden measures resulted in classes of tumors whose epigenetic and genetic burden profile were associated with the PAM50 subtype and mutations in TP53, PIK3CA, and CDH1.27070496
Breast CarcinomaEpigenetic AlterationsTogether, our work presents a novel framework for characterizing the epigenetic burden and adds to the understanding of the aggregate impact of epigenetic and genetic alterations in breast cancer.27070496
Malignant tumor of colonEpigenetic AlterationsLong Non-Coding RNA lincRNA-ROR Promotes the Progression of Colon Cancer and Holds Prognostic Value by Associating with miR-145.27071407
Malignant neoplasm of liverEpigenetic AlterationsLarge intergenic non-coding RNA ribonucleic acids-ROR (lincRNA-ROR) has been reported to exert impacts on the maintenance of induced pluripotent stem cells and embryonic stem cells, and play important roles in human hepatocellular cancer.27071407
STK19 geneEpigenetic AlterationsRP1-13D10.2 is a long noncoding RNA that regulates LDLR and may contribute to low-density lipoprotein cholesterol response to statin treatment.27071970
Heart failureEpigenetic AlterationsDifferential microRNA expression in peripheral blood has been observed in patients with heart failure, suggesting their value as potential biomarkers and likely contributors to disease mechanisms.27072074
Cardiovascular DiseasesEpigenetic AlterationsThe expression of microRNAs was analysed using real-time PCR by the miScript miRNA PCR Array Human Cardiovascular Disease.27072074
Heart failure, Heart DiseasesEpigenetic AlterationsIn silico analyses suggest that the transcardiac gradient of microRNAs in heart failure may target pathways related to heart disease.27072074
Heart failure, Fibrosis AssessmentEpigenetic AlterationsThe microRNAs described here may have a role in the pathophysiology of heart failure as they might be involved in pathways related to disease progression, including fibrosis.27072074
Malignant neoplasm of urinary bladderEpigenetic AlterationsRegulation of UHRF1 by dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p): Inhibition of bladder cancer cell aggressiveness.27072587
NeoplasmsEpigenetic AlterationsThe identification of the molecular target of a tumor suppressive miRNAs provides novel insights into the potential mechanisms of BC oncogenesis and suggests novel therapeutic strategies.27072587
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNA-124 Functions as a Tumor Suppressor by Regulating CDH2 and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer.27073840
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAbnormal expression of microRNA-124 (miR-124) was found in non-small cell lung cancer (NSCLC).27073840
Prostate Cancer PathwayEpigenetic AlterationsmiRNA-154-5p Inhibits Proliferation, Migration and Invasion by Targeting E2F5 in Prostate Cancer Cell Lines.27074041
Non-alcoholic Fatty Liver DiseaseEpigenetic AlterationsRelationships between circulating microRNA-122 (miR-122) and histological features of nonalcoholic fatty liver disease (NAFLD) are unclear.27074850
Non-Small Cell Lung CarcinomaEpigenetic AlterationsPlasma miRNAs in predicting radiosensitivity in non-small cell lung cancer.27075472
palladium, Stable DiseaseEpigenetic AlterationsFour miRNAs (hsa-miR-98-5p, hsa-miR-302e, hsa-miR-495-3p, and hsa-miR-613) demonstrated a higher expression in effective group (CR + PR, 15 cases) than in ineffective group (SD + PD, 39 cases).27075472
Non-Small Cell Lung CarcinomaEpigenetic AlterationsBioinformatical analysis and clinical verification reveal the correlation between plasma miRNAs and radiosensitivity in NSCLC patients.27075472
Primary malignant neoplasmEpigenetic AlterationsBlood Epigenetic Age may Predict Cancer Incidence and Mortality.27077113
Primary malignant neoplasmEpigenetic AlterationsParticipants with smaller Dage and decelerated epigenetic aging over time had the lowest risks of cancer incidence (P = 0.003) and mortality (P = 0.02).27077113
Primary malignant neoplasmEpigenetic AlterationsWe conclude that blood epigenetic age may mirror epigenetic abnormalities related to cancer development, potentially serving as a minimally invasive biomarker for cancer early detection.27077113
Communicable DiseasesEpigenetic AlterationsEspecially, human miRNA mir-146a expression seems to be downregulated by HCMV infection in vitro.27077822
Hollings Cancer CenterEpigenetic AlterationsHypermethylation of promoter regions is the main epigenetic mechanism of gene silencing and has been involved in HCC development.27078152
Hollings Cancer CenterEpigenetic AlterationsRASSF1A and DOK1 promoter hypermethylation may be a valuable biomarker for early diagnosis of HCC and a potential molecular target for epigenetic-based therapy.27078152
Stomach Carcinoma, Neoplasm MetastasisEpigenetic AlterationsMicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer.27078844
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNA) play an important role in carcinogenesis.27078844
Stomach CarcinomaEpigenetic AlterationsPreviously, we identified miR-26b as a significantly downregulated miRNA in gastric cancer (GC) tissues (n = 106) based on differential quantitative RT-PCR (RT-qPCR) miRNA expression profiles.27078844
Intracranial Arteriovenous Malformation, Intracranial AneurysmEpigenetic AlterationsSex-dichotomous effects of NOS1AP promoter DNA methylation on intracranial aneurysm and brain arteriovenous malformation.27080431
NeoplasmsEpigenetic AlterationsTissues were microdissected to obtain >90% tumor or normal lung cells, subjected to miRNA transcriptome sequencing and TaqMan quantitative PCR validation.27081085
Adenocarcinoma of lung (disorder)Epigenetic AlterationsWe identified known and novel, significantly over- and under-expressed (p <= 0.01 and FDR<=0.1) miRNAs in lung adenocarcinoma compared to normal lung tissue: let-7a, miR-10a, miR-15b, miR-23b, miR-26a, miR-26b, miR-29a, miR-30e, miR-99a, miR-146b, miR-181b, miR-181c, miR-421, miR-181a, miR-574 and miR-1247.27081085
Prostate Cancer PathwayEpigenetic AlterationsUrinary microRNA-based signature improves accuracy of detection of clinically relevant prostate cancer within the prostate-specific antigen grey zone.27081843
Colorectal CarcinomaEpigenetic AlterationsMicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers.27082577
Primary malignant neoplasmEpigenetic AlterationsBioinformatics analysis showed that the DE-miRNAs were significantly enriched in cancer-associated pathways including neutrophin signaling (P = 6.84 x 10(-5)), pathways in cancer (P = 0.0016), Wnt signaling (P = 0.0027), and MAPK signaling pathway (P = 0.0036).27082577
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNAs (miRNAs) and transcription factors (TFs) are two major regulators of gene expression, which may play important roles in the etiology of AML.27082628
Leukemia, Myelocytic, AcuteEpigenetic AlterationsHowever, the global regulation of gene expression in AML, involving miRNAs and TFs, still remains elusive.27082628
Stomach CarcinomaEpigenetic AlterationsFurthermore, epigenetic inactivation of SLIT occurred in a gastric cancer subtype-dependent manner.27082735
Intracranial AneurysmEpigenetic AlterationsMicroRNA-29a: A potential biomarker in the development of intracranial aneurysm.27084222
Intracranial AneurysmEpigenetic AlterationsTo identify serum microRNA-29a (miR-29a) level in patients with intracranial aneurysm and its role in the development of intracranial aneurysm (IA).27084222
Dermoid cyst with secondary tumorEpigenetic AlterationsProspective validation of microRNA signatures for detecting pancreatic malignant transformation in endoscopic-ultrasound guided fine-needle aspiration biopsies.27086919
Dermoid cyst with secondary tumorEpigenetic AlterationsWe demonstrate the feasibility of using fresh EUS-FNAs to establish miRNA-based signatures unique to pancreatic malignant transformation and the potential to enhance risk stratification and selection for surgery.27086919
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are potentially ideal diagnostic biomarkers, as they are stable molecules, and tumour and tissue specific.27086919
malignant diseaseEpigenetic AlterationsValidation FNA cohorts confirmed both miRNAs were overexpressed in malignant disease, while circulating miRNAs performed poorly.27086919
Malignant NeoplasmsEpigenetic AlterationsWe provide further evidence for using miRNAs as diagnostic biomarkers for pancreatic malignancy.27086919
Primary malignant neoplasmEpigenetic AlterationsPrognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer.27092493
Primary malignant neoplasmEpigenetic AlterationsQuantitative real-time polymerase chain reaction (qPCR) was performed on an independent set of 147 rectal cancer patients to validate relevant miRNAs.27092493
Admitting diagnosisEpigenetic AlterationsTo understand better the epigenetic mechanisms regulating CRTC1 expression that may be altered in AD, we profiled DNA methylation at CpG site resolution by bisulfite cloning sequencing in two promoter regions (referred to as Prom1 and Prom2) of the CRTC1 gene in human hippocampus from controls and AD cases.27094739
Admitting diagnosisEpigenetic AlterationsDNA methylation levels within two distinct promoter regions of the CRTC1 gene were decreased in human hippocampus affected by AD compared with controls and methylation within Prom1 showed a strong inverse correlation with p-tau deposition.27094739
MetastasisEpigenetic AlterationsIn addition, we have identified a set of SCNAs, including amplification of BRAF and ofthe epigenetic modifier EZH2, that are specific for the group of thick melanomas that developed metastasis during the follow-up.27095580
Oropharyngeal CarcinomaEpigenetic AlterationsThe microRNA expression profiles were analyzed by micro-arrays in 26 oropharyngeal cancers.27097597
Oropharyngeal CarcinomaEpigenetic AlterationsA microRNA signature specific to HPV-status was identified by analyzing a learning/training set consisting of 16 oropharyngeal cancers.27097597
Oropharyngeal CarcinomaEpigenetic AlterationsWe have identified 25 miRNA signatures, which discriminates HPV16-positive oropharyngeal cancer from their HPV-negative counterparts.27097597
Breast CarcinomaEpigenetic AlterationsThere have been no prior studies on the question whether or not samples processed by OSNA can be used for further molecular studies, including epigenetic abnormalities which are some of the most important molecular alterations in breast cancer.27097811
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsExpression level of microRNA-195 in the serum of patients with gastric cancer and its relationship with the clinicopathological staging of the cancer.27097947
SF3B1 wt Allele, MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsGenetic and epigenetic alterations contribute to the biological and clinical characteristics of myelodysplastic syndromes (MDS), but a role for socioeconomic environment remains unclear.27098194
Liver carcinomaEpigenetic AlterationsMicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST.27100897
Malignant NeoplasmsEpigenetic AlterationsMicroRNA (miRNA) and long non-coding RNA (lncRNA) have been demonstrated to participate in the progression of many cancers.27100897
Metastasis, Hollings Cancer CenterEpigenetic AlterationsFurthermore, long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) and miR-92b could directly interact with and repress each other, and XIST could inhibit HCC cell proliferation and metastasis by targeting miR-92b.27100897
Lymphoma, Follicular, LymphomaEpigenetic AlterationsPrioritized alterations in epigenetic modulators were common and included gain-of-function EZH2 and loss-of-function ARID1A mutations (14% of diffuse large B-cell lymphomas and 22% of follicular lymphomas contained alterations in each of these two genes).27102345
melanomaEpigenetic AlterationsWe have demonstrated that loss of ten-eleven translocation methylcytosine dioxygenase (TET2)-mediated 5-hydroxymethylcytosine (5-hmC) is an epigenetic driver of melanoma growth and a biomarker of clinical virulence.27102770
Disease, Primary malignant neoplasmEpigenetic AlterationsDysregulated long noncoding RNAs (lncRNAs) have been found in human diseases, especially in cancer.27104549
Adenocarcinoma of lung (disorder)Epigenetic AlterationsRelapse-related long non-coding RNA signature to improve prognosis prediction of lung adenocarcinoma.27105492
Metastasis, NeoplasmsEpigenetic AlterationsIncreasing evidence has highlighted the important roles of dysregulated long non-coding RNA (lncRNA) expression in tumorigenesis, tumor progression and metastasis.27105492
Hypertensive diseaseEpigenetic AlterationsThe identification of these novel CpG sites may contribute to a further understanding of the epigenetic regulatory mechanisms underlying the development of essential hypertension.27105587
nervous system disorderEpigenetic AlterationsWith ~50% of miRNAs expressing in the brain, they play an important role in neuronal development, plasticity, cognition and neurological disorders.27106592
Neurofibromatosis 1Epigenetic AlterationsIs Neurofibromatosis Type 1-Noonan Syndrome a Phenotypic Result of Combined Genetic and Epigenetic Factors?27107091
Malignant NeoplasmsEpigenetic AlterationsACTG2 and microRNA-145 (miR-145) are aberrantly expressed in other cancers and ACTG2 can be induced by miR-145.27107594
Metastasis, Neoplasms, Renal Cell Carcinoma PathwayEpigenetic AlterationsMicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma.27108693
Refractory Cytopenia of ChildhoodEpigenetic AlterationsConsistently, overexpression of miR-126 in RCC cells significantly inhibited cell proliferation, migration and invasion in vitro compared with negative control miRNA.27108693
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are involved in cancer development and progression.27108693
Lupus FlareEpigenetic AlterationsEpigenetic Reprogramming in Naive CD4+ T Cells Favoring T Cell Activation and Non-Th1 Effector T Cell Immune Response as an Early Event in Lupus Flares.27111767
Lupus ErythematosusEpigenetic AlterationsWe demonstrated that naive CD4+ T cells in lupus undergo an epigenetic proinflammatory shift, implicating effector T cell responses in lupus flare.27111767
Lupus ErythematosusEpigenetic AlterationsBioinformatics analyses indicate that the epigenetic modulator EZH2 might play an important role in shifting the epigenetic landscape, with increased disease activity in lupus naive CD4+ T cells.27111767
Lupus ErythematosusEpigenetic AlterationsFurther, the expression of microRNA-26a, which is sensitive to glucose availability and targets EZH2, was negatively correlated with disease activity in lupus patients.27111767
Stomach Carcinoma, Helicobacter pylori, Gastritis, Egyptian languageEpigenetic AlterationsBraf, Kras and Helicobacter pylori epigenetic changes-associated chronic gastritis in Egyptian patients with and without gastric cancer.27116958
Primary malignant neoplasmEpigenetic AlterationsH. pylori may cause epigenetic changes predisposing the patients to cancer stomach.27116958
Prostate Cancer PathwayEpigenetic AlterationsNovel diagnostic and prognostic classifiers for prostate cancer identified by genome-wide microRNA profiling.27120795
Primary malignant neoplasmEpigenetic AlterationsmiRNAs have been reported to be involved in numerous cell processes, including cell apoptosis, proliferation and migration, thus suggesting that miRNAs may have an important role in cancer progression.27121091
Prostate Cancer PathwayEpigenetic AlterationsRisk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies.27121847
Primary malignant neoplasmEpigenetic AlterationsCompared to other risk factors, detection of DNA-methylation in histopathologically negative biopsies was the most significant and important predictor of high-grade cancer, resulting in a NPV of 96%.27121847
Primary malignant neoplasmEpigenetic AlterationsLow DNA-methylation levels in PCa-negative biopsies led to a NPV of 96% for high-grade cancer.27121847
Primary malignant neoplasmEpigenetic AlterationsThe risk score, comprising DNA-methylation intensity and traditional clinical risk factors, improved the identification of men with high-grade cancer, with a maximum avoidance of unnecessary repeat biopsies.27121847
melanoma, NeoplasmsEpigenetic AlterationsMicroRNA-199a-5p inhibits tumor proliferation in melanoma by mediating HIF-1a.27122154
melanomaEpigenetic AlterationsThe expression of miRNA-199a-5p (miR-199a-5p) in melanoma was detected by quantitative polymerase chain reaction on samples from 25 melanoma patients.27122154
InitiationEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have come into focus for their important regulatory roles in fundamental biological processes, particularly in cancer initiation, development and progression.27122348
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA Seed Region Length Impact on Target Messenger RNA Expression and Survival in Colorectal Cancer.27123865
Carcinoma, Clinical Coordinator, Dying ProcessEpigenetic AlterationsWe analyzed these groups in terms of miRNA differential expression between carcinoma and normal colorectal mucosa, differential colonic target mRNA expression, and risk of dying from CRC.27123865
Cardiovascular DiseasesEpigenetic AlterationsCirculating microRNA has recently emerged as a promising biomarker for cardiovascular disease.27124025
HypoxiaEpigenetic AlterationsHypoxia has been shown to alter DNA methylation, an epigenetic mechanism involved in regulating gene expression such as the pro-fibrotic transforming growth factor (TGF) b1 and the anti-fibrotic Ras protein activator like 1 (RASAL1).27124111
NTM geneEpigenetic AlterationsWe found increased DNA methylation, increased TGFb1 expression and decreased RASAL1 expression in GTM cells compared to NTM cells.27124111
NTM geneEpigenetic AlterationsTGFb1 and RASAL1 expression, global DNA methylation, and expression of associated methylation enzymes were altered between NTM and GTM cells.27124111
Glaucoma, CTCAEEpigenetic AlterationsFurthermore, DNA methylation, TGFb1 and RASAL1 appear to have an interacting relationship that may play a role in driving pro-fibrotic disease progression in the glaucomatous TM.27124111
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMarkers of epigenetic aberrations have shown promising results in several cancer types and can be assessed by automatic analysis of chromatin organisation in tumour cell nuclei.27124335
Primary malignant neoplasmEpigenetic AlterationsWe analyzed the relationship between multivariable molecular data and LTS in GBM patients from the Cancer Genome Atlas (TCGA), including germline and somatic point mutation, gene expression, DNA methylation, copy number variation (CNV) and microRNA (miRNA) expression using logistic regression models.27124395
Colorectal Cancer PathwayEpigenetic AlterationsDevelopment of a deregulating microRNA panel for the detection of early relapse in postoperative colorectal cancer patients.27126129
Clinical CoordinatorEpigenetic AlterationsMicroRNA (miR) deregulation is associated with CRC development and recurrence; therefore, miRs may be reliable biomarkers for detecting early relapse postoperatively.27126129
Colorectal Cancer PathwayEpigenetic AlterationsSerum microRNA-135a-5p as an auxiliary diagnostic biomarker for colorectal cancer.27126269
Diabetes MellitusEpigenetic AlterationsMicro-RNA-126 Reduces the Blood Thrombogenicity in Diabetes Mellitus via Targeting of Tissue Factor.27127202
Chronic Lymphocytic LeukemiaEpigenetic AlterationsPrognostic impact of epigenetic classification in chronic lymphocytic leukemia: The case of subset #2.27128508
Chronic Lymphocytic LeukemiaEpigenetic AlterationsBased on the methylation status of 5 single CpG sites, a novel epigenetic classification of chronic lymphocytic leukemia (CLL) was recently proposed, classifying CLL patients into 3 clinico-biological subgroups with different outcome, termed memory like CLL (m-CLL), naive like CLL (n-CLL), and a third intermediate CLL subgroup (i-CLL).27128508
Chronic Lymphocytic LeukemiaEpigenetic AlterationsIn summary, we validated the epigenetic classifier as an independent factor in CLL prognostication and provide further evidence that subset #2 is a member of the i-CLL group, hence supporting the existence of a third, intermediate epigenetic subgroup.27128508
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsLong non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis.27130667
Malignant Neoplasms, Malignant neoplasm of urinary bladderEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been suggested to play important roles in the progression of many cancers such as bladder cancer.27130667
PsoriasisEpigenetic AlterationsThere are no published studies that describe the DNA methylation of human leukocyte antigen class I molecules in psoriasis despite the fact that their association to disease has been known for several decades.27132688
PsoriasisEpigenetic AlterationsHypermethylation of HLA-C may be an epigenetic marker in psoriasis.27132688
PsoriasisEpigenetic AlterationsWe first demonstrate hypermethylation of HLA-C gene in psoriatic epidermis, suggesting that HLA-C hypermethylation may be an epigenetic marker in psoriasis.27132688
NeoplasmsEpigenetic AlterationsA combined clinical, genetic, and epigenetic model for detecting synchronous neoplasm by testing of non-neoplastic colonic tissue had favorable operating characteristics and could complement current patient care.27135485
Leukemia, Myelocytic, AcuteEpigenetic AlterationsRUNX1 mutations were found in 245 of 2439 (10%) patients; were almost mutually exclusive of AML with recurrent genetic abnormalities; and they co-occurred with a complex pattern of gene mutations, frequently involving mutations in epigenetic modifiers (ASXL1, IDH2, KMT2A, EZH2), components of the spliceosome complex (SRSF2, SF3B1) and STAG2, PHF6, BCOR.27137476
Prostatic NeoplasmsEpigenetic AlterationsProstate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes.27142338
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsDNA methylation has been hypothesized as a mechanism for explaining the association between smoking and adverse prostate cancer (PCa) outcomes.27142338
CHOANAL ATRESIA, POSTERIOR, NeoplasmsEpigenetic AlterationsA total of 523 men had radical prostatectomy as their primary treatment, detailed smoking history data, long-term follow-up for PCa outcomes, and tumor tissue profiled for DNA methylation.27142338
NeoplasmsEpigenetic AlterationsThis integrative molecular epidemiology study supports the hypothesis that smoking-associated tumor DNA methylation changes may explain at least part of the association between smoking and adverse PCa outcomes.27142338
Carcinogenesis, Epstein-Barr virus associated gastric carcinomaEpigenetic AlterationsA systemic profiling of ebv-miRNAs expressed in EBV-associated gastric carcinoma (EBVa GC) helps understand its epigenetic regulation of carcinogenesis.27144885
NeoplasmsEpigenetic AlterationsComprehensive profiling of virus microRNAs of Epstein-Barr virus-associated gastric carcinoma: highlighting the interactions of ebv-Bart9 and host tumor cells.27144885
Neoplastic diseaseEpigenetic AlterationsEpstein-Barr virus (EBV) is suggested to actively utilize its ebv-microRNAs (miRNAs) to manipulate viral and cellular functions during neoplasia transformation.27144885
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsRecently, growing evidence has indicated that deregulation of microRNAs (miRNAs) contributes to tumorigenesis and tumor progression in colorectal cancer (CRC).27145368
precancerous lesions, Colorectal Traditional Serrated AdenomaEpigenetic AlterationsTo clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we assessed the DNA methylation of cancer-associated genes in a cohort of BRAF-mutant precancerous lesions from 94 individuals.27145369
ColorectalEpigenetic AlterationsAssessment of epigenetic alterations in early colorectal lesions containing BRAF mutations.27145369
Primary malignant neoplasmEpigenetic AlterationsCommon single nucleotide polymorphisms (SNPs) in miRNAs may affect miRNA functions and their target expression and thus may affect biological activities and cancer etiology as well as prognosis.27145460
Hepatitis C, Virus Diseases, Hepatobiliary DisorderEpigenetic AlterationsHepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis.27147737
Virus DiseasesEpigenetic AlterationsWhile host miRNAs are essential for HCV replication, viral infection in turn appears to induce alterations of intrahepatic miRNA networks.27147737
Hepatobiliary Disorder, Primary malignant neoplasmEpigenetic AlterationsmiRNA expression is known to be deregulated in liver disease and cancer.27147737
Communicable DiseasesEpigenetic AlterationsFurthermore, miRNAs are essential for HCV replication, and HCV infection alters miRNA expression.27147737
Hepatobiliary Disorder, Hollings Cancer CenterEpigenetic AlterationsMicroRNAs (miRNAs) play an important role in homeostasis within the liver, and deregulation of miRNAs has been associated with liver disease, including HCC.27147737
Hepatobiliary Disorder, Hollings Cancer CenterEpigenetic AlterationsAlthough the cross talk between HCV and liver cell miRNAs most likely contributes to liver disease pathogenesis, the functional involvement of miRNAs in HCV-driven hepatocyte injury and HCC remains elusive.27147737
Injury of liver, CarcinogenesisEpigenetic AlterationsHere we show that HCV induces miRNAs that may contribute to liver injury and carcinogenesis.27147737
Nasopharyngeal carcinoma, MetastasisEpigenetic AlterationsMicroRNA-23b regulates nasopharyngeal carcinoma cell proliferation and metastasis by targeting E-cadherin.27150436
Metastasis, NeoplasmsEpigenetic AlterationsMicroRNA-23b (miR-23b) is important in tumor proliferation and metastasis.27150436
Chronic liver disease, Fibrosis AssessmentEpigenetic AlterationsGenetic variants and environmental cues influence predisposition to the development of chronic liver disease; however, it remains unknown if aberrant DNA methylation is associated with fibrosis progression in chronic hepatitis B.27152124
Chronic liver disease, HepatitisEpigenetic AlterationsTo identify epigenetic marks associated with inflammatory and fibrotic processes of the hepatitis B-induced chronic liver disease, we carried out hepatic genome-wide methylation profiling using Illumina Infinium BeadArrays comparing mild and severe fibrotic disease in a discovery cohort of 29 patients.27152124
Hepatitis BEpigenetic AlterationsOur findings suggest a linkage of widespread epigenetic dysregulation with disease progression in chronic hepatitis B infection.27152124
Breast CarcinomaEpigenetic AlterationsA Set of miRNAs, Their Gene and Protein Targets and Stromal Genes Distinguish Early from Late Onset ER Positive Breast Cancer.27152840
Mammary NeoplasmsEpigenetic AlterationsWe proposed that differentially expressed miRNAs could regulate genes and proteins underlying aggressive phenotypes of breast tumors in YA patients when compared to those arising in MA patients.27152840
Malignant neoplasm of breast, Aggressive behaviorEpigenetic AlterationsWe defined a set of differentially expressed miRNAs, their mRNAs and protein targets and stromal genes that distinguish early onset from late onset ER positive breast cancers which may be involved with tumor aggressiveness of YA-BC.27152840
Small cell carcinoma of lungEpigenetic AlterationsPrognostic impact of a 3-MicroRNA signature in cytological samples of small cell lung cancer.27153322
Carcinoma of lungEpigenetic AlterationsMicroRNA (miRNA) signatures have been recently proposed as useful biomarkers in lung cancer because of their high stability during standard sample processing.27153322
Small cell carcinoma of lungEpigenetic AlterationsA specific 3-miRNA signature is potentially useful for predicting survival for patients with SCLC, and it may be feasible with cytological samples taken during standard diagnostic procedures.27153322
Muscular Dystrophy, FacioscapulohumeralEpigenetic AlterationsMutations in DNMT3B Modify Epigenetic Repression of the D4Z4 Repeat and the Penetrance of Facioscapulohumeral Dystrophy.27153398
Muscular Dystrophy, FacioscapulohumeralEpigenetic AlterationsThis study suggests that transcription of DUX4 in somatic cells is modified by variations in its epigenetic state and provides a basis for understanding the reduced penetrance of FSHD within families.27153398
Multiple MyelomaEpigenetic AlterationsIdentification of a novel microRNA, miR-4449, as a potential blood based marker in multiple myeloma.27155004
Primary malignant neoplasmEpigenetic AlterationsmiRNAs act in diverse biological processes including development, cell growth, apoptosis, and hematopoiesis, suggesting their role in cancer.27155004
AsthmaEpigenetic AlterationsWe sought to associate miRNA expression in sputum supernatants with the inflammatory cell profile and disease severity in asthmatic patients.27155035
AsthmaEpigenetic AlterationsDifferentially expressed miRNAs were validated in an independent cohort (n = 60; 10 healthy subjects and 50 asthmatic patients).27155035
Neutrophilia (finding), Airway ObstructionEpigenetic AlterationsExpression of the 3 miRNAs was associated with sputum neutrophilia, and miR-223-3p and miR-142-3p expression was associated also with airway obstruction (FEV1/forced vital capacity).27155035
Asthma Pathway, Airway structureEpigenetic AlterationsExpression of miR-223-3p, miR-142-3p, and miR-629-3p is increased in sputum of patients with severe asthma and is linked to neutrophilic airway inflammation, suggesting that these miRNAs contribute to this asthma inflammatory phenotype.27155035
Huntington Disease, ImpairedEpigenetic AlterationsCirculating microRNAs in Huntingtons disease: Emerging mediators in metabolic impairment.27155059
Malignant neoplasm of urinary bladderEpigenetic AlterationsImproved Noninvasive Bladder Cancer Diagnosis using Urine Sediments and Novel DNA Methylation Biomarker Panels.27156320
Carcinogenesis, NeoplasmsEpigenetic AlterationsAberrant DNA methylation status early in carcinogenesis represents a potential indicator of tumor detection.27156320
Malignant neoplasm of urinary bladderEpigenetic AlterationsWe would like to establish a DNA methylation biomarker panel for bladder cancer detection in the research.27156320
Malignant neoplasm of urinary bladderEpigenetic AlterationsUsing the urine of bladder cancer patients and healthy controls, we assessed several novel DNA methylation biomarker panels that demonstrated good bladder cancer detection capability.27156320
Malignant neoplasm of urinary bladderEpigenetic AlterationsExpression Level of Urinary MicroRNA-146a-5p Is Increased in Patients With Bladder Cancer and Decreased in Those After Transurethral Resection.27157639
Primary malignant neoplasmEpigenetic AlterationsWe identified 3 miRNAs (miR-301b, -563, and -146a-5p) that demonstrated > 2-fold higher expression levels in cancer cell lines than in the normal ureteral epithelial tissue.27157639
Carcinogenesis, NeoplasmsEpigenetic AlterationsEpigenetic modifications, including DNA methylation of tumor suppressor genes carried out by DNA methyltransferases (DNMTs), are important events in carcinogenesis.27159259
Prostate Cancer PathwayEpigenetic AlterationsMicroRNA (miRNA) has been shown to be associated with the initiation and progression of prostate cancer.27164937
Secondary malignant neoplasm of liver, Colorectal Cancer PathwayEpigenetic AlterationsGenome-wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis.27165481
Clinical Coordinator, Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsThe liver is the most frequent site of metastasis in colorectal cancer (CRC), in which long noncoding RNAs (lncRNAs) may play a crucial role.27165481
Primary malignant neoplasmEpigenetic AlterationsBackground MicroRNAs have been implicated in many biological pathways involved in tumourigenesis and can serve as prognostic biomarkers in many cancer types.27166306
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-21 is overexpressed in most cancers and has been implicated in tumorigenesis.27166999
NeoplasmsEpigenetic AlterationsA microRNA (miRNA) that functionally downregulates the expression of tumor suppressors can be defined as an oncomir.27167185
Malignant neoplasm of urinary bladderEpigenetic AlterationsSerum microRNA expression signatures as novel noninvasive biomarkers for prediction and prognosis of muscle-invasive bladder cancer.27167342
DementiaEpigenetic AlterationsHomocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia.27167582
DementiaEpigenetic AlterationsEpigenetics (particularly DNA methylation) together with environmental and genetic factors, are key to understanding the pathogenesis of many diseases including dementia.27167582
DementiaEpigenetic AlterationsDisturbances in DNA methylation have already been implicated in dementia.27167582
Dementia, VascularEpigenetic AlterationsA non-significant tendency to higher DNA methylation in patients with vascular dementia (p=0.061) was observed.27167582
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsOur studies of microRNA (miRNA) expression signatures have shown that microRNA-1 (miR-1) and microRNA-206 (miR-206) were downregulated in head and neck squamous cell carcinoma (HNSCC) clinical specimens.27169691
Squamous cell carcinoma of the head and neckEpigenetic AlterationsThe seed sequences of these miRNAs are identical, suggesting that the identification of the molecular targets regulated by miR-1 and miR-206 will provide new insights into novel mechanisms of HNSCC pathogenesis.27169691
NeoplasmsEpigenetic AlterationsThis miRNA was up-regulated in high grade (P=0.041), the TMPRSS2-ERG fusion-positive tumors (P=0.026), and in patients with subsequently developed biochemical recurrence (BCR; P=0.054) after radical prostatectomy.27170485
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsIn PCa, the diagnostic potential of urinary miRNA panel (miR-21, miR-19a, and miR-19b) was higher than that of the PSA test (AUC=0.738 vs. AUC=0.514).27170485
Prostate Cancer PathwayEpigenetic AlterationsDetection of miRNAs in urine of prostate cancer patients.27170485
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsMiRNAs highly expressed in PCa tissues were also detectable in urine from PCa patients.27170485
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsMeasurement of urinary levels of PCa-specific miRNAs could assist in more specific detection of PCa and prediction of BCR.27170485
Primary malignant neoplasmEpigenetic AlterationsEpigenetic deregulation is considered as a new hallmark of cancer.27172249
Malignant Neoplasms, Breast CarcinomaEpigenetic AlterationsThe long non-coding RNA MALAT1 has been implicated in several cancers; however, its role in breast cancer is still little known.27172249
Endothelial dysfunctionEpigenetic AlterationsLow levels of sCD40L 1 month after PCI distinguish STEMI patients with worse prognosis, a compromised cardiac healing, and a persistent endothelial dysfunction, as given by the association between sCD40L, NT-proBNP, G894T polymorphism, and specific profile of miRNA expression.27172386
Hypertrophic CardiomyopathyEpigenetic AlterationsLower quartiles of sCD40L (<2.3 ng/mL) were associated with higher concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP), high frequency of G894T polymorphism, and altered expression of a set of microRNAs assumed to be involved in the regulation of endothelial and cardiac function and myocardium hypertrophy, relative to patients in sCD40L upper quartiles.27172386
Malignant NeoplasmsEpigenetic AlterationsMicroRNA 141 Expression Is a Potential Prognostic Marker of Biliary Tract Cancers.27172928
Liver and Intrahepatic Biliary Tract CarcinomaEpigenetic AlterationsOverexpression of miRNA 141 is an indicator of a poor prognosis in patients with biliary tract cancer, suggesting that miRNA 141 may be a valuable prognostic biomarker of this disease.27172928
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsIn recent years, a large number of microribonucleic acids (miRNAs) have been identified as putative prognostic biomarkers for solid cancers because of their role in controlling the expression of oncogenes and tumor suppressor genes.27172928
Malignant NeoplasmsEpigenetic AlterationsMany microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers.27173192
Prostate Cancer PathwayEpigenetic AlterationsPrediction efficiency of PITX2 DNA methylation for prostate cancer survival.27173224
NeoplasmsEpigenetic AlterationsA higher degree of PITX2 DNA methylation was associated with higher tumor stage and lower survival rates.27173224
Prostate Cancer PathwayEpigenetic AlterationsPITX2 DNA methylation presents a good predictive value for prostate cancer survival.27173224
Stomach CarcinomaEpigenetic AlterationsDeregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC).27173244
Stomach CarcinomaEpigenetic AlterationsIdentification and functional characterization of microRNAs reveal a potential role in gastric cancer progression.27173517
Tetranitromethane, Metastasis, NeoplasmsEpigenetic Alterations22 GC specific key miRNAs were identified (Fold-change >2, P < 0.05), 11 of them were discriminatively expressed with tumor size, grade, TNM stage and lymphatic metastasis (P < 0.05).27173517
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAge-dependent epigenetic alterations or other somatic changes might collaborate with the mutation to cause AML.27174803
Malignant NeoplasmsEpigenetic AlterationsCertain microRNAs (miRs) are implicated in the genesis and progression of various cancers by regulating multiple cellular processes, including apoptosis, proliferation and migration.27175581
Malignant neoplasm of thyroidEpigenetic AlterationsMicroRNA-126 is downregulated in thyroid cancer cells, and regulates proliferation, migration and invasion by targeting CXCR4.27175968
Esophageal carcinomaEpigenetic AlterationsTo the best of our knowledge, this is the first report describing DNA methylation-mediated silencing of miR-193b in esophageal cancer and BE tissues.27176876
Barrett EsophagusEpigenetic AlterationsAberrant methylation of microRNA-193b in human Barretts esophagus and esophageal adenocarcinoma.27176876
Glioblastoma MultiformeEpigenetic AlterationsThe correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients.27176932
InflammationEpigenetic AlterationsOur results suggest that epigenetic changes participate in chronic inflammation and aging in the palatine tonsils.27180790
Breast CarcinomaEpigenetic AlterationsmicroRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection.27180809
Columnar Metaplasia, Communicable DiseasesEpigenetic AlterationsDNA methylation occurs in cases of gastric-type (non-specialized) columnar metaplasia of the esophagus, and this modification is associated with H. pylori cagA positive infection.27182166
Triple-Negative Breast Cancer Finding, NeoplasmsEpigenetic AlterationsLong-term soy consumption and tumor tissue MicroRNA and gene expression in triple-negative breast cancer.27183356
NeoplasmsEpigenetic AlterationsA total of 14 miRNAs and 24 genes were significantly associated with soy food intake (P < .05): Thirteen of the 14 miRNAs (92.9%) and 9 of the 24 genes (37.5%), including tumor suppressors miR-29a-3p and IGF1R, showed overexpression for those women with high soy intake, whereas the remaining miRNAs and genes, including oncogenes KRAS and FGFR4, showed underexpression.27183356
Skeletal muscle structureEpigenetic AlterationsOur results provide insights into the potential regulatory role of epigenetic histone acetylation of the miR-449a promoter that may regulate its expression in the diabetic skeletal muscle.27184529
Esophageal carcinomaEpigenetic AlterationsMicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer.27188433
DiseaseEpigenetic AlterationsIncreasing evidence shows that single nucleotide polymorphisms (SNPs) or mutations in miRNAs sequence may affect the processing and function of miRNAs and participate in the occurrence of diseases.27188998
Carcinoma of lungEpigenetic AlterationsMicroRNAs associated with increased AKT gene number in human lung carcinoma.27189341
Gastric Cardia AdenocarcinomaEpigenetic AlterationsMethylation-mediated downregulation of long noncoding RNA LOC100130476 in gastric cardia adenocarcinoma.27189370
Carcinogenesis, Metastasis, Primary malignant neoplasmEpigenetic AlterationsAccumulating evidences indicate that long non-coding RNAs (lncRNAs) play important roles in several biological processes and dysregulated lncRNAs are involved in different kinds of cancer and are associated with carcinogenesis, metastasis, and prognosis of cancer.27189370
Breast Cancer Cell, Adenocarcinoma of lung (disorder)Epigenetic AlterationsLong non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (Malat1) functions as an oncogene in many types of human cancer.27191262
Malignant tumor of colonEpigenetic AlterationsmicroRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway.27191497
NeoplasmsEpigenetic AlterationsmicroRNA-374a (miR-374a) exhibits oncogenic functions in various tumor types.27191497
Non-Small Cell Lung CarcinomaEpigenetic AlterationsA unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer.27191990
Carcinoma of lung, Chronic Obstructive Airway DiseaseEpigenetic AlterationsThe purpose of this study was to identify circulating microRNAs for detection of early stage lung cancer, capable of discriminating lung cancer patients from those with chronic obstructive pulmonary disease (COPD) and healthy volunteers.27191990
Carcinoma of lungEpigenetic AlterationsWe identified 7 microRNAs separating lung cancer patients from controls.27191990
Non-Small Cell Lung CarcinomaEpigenetic AlterationsBy using RT-qPCR, we validated 6 microRNAs (miR-429, miR-205, miR-200b, miR-203, miR-125b and miR-34b) with a significantly higher abundance in serum from NSCLC patients.27191990
Hollings Cancer CenterEpigenetic AlterationsMoreover, we found that miR-129-2 was downregulated by DNA methylation, and demethylation of miR-129-2 increased miR-129-2 expression in HCC cells and resulted in significant inhibitory effects on cell migration and invasion.27191994
Aggressive behavior, Liver carcinomaEpigenetic AlterationsMethylation-mediated repression of microRNA-129-2 suppresses cell aggressiveness by inhibiting high mobility group box 1 in human hepatocellular carcinoma.27191994
Primary malignant neoplasmEpigenetic AlterationsAberrant expression of microRNAs (miRNAs) and its dysfunction have been revealed as crucial modulators of cancer initiation and progression.27191994
Mucosal Melanoma, Malignant melanoma of conjunctivaEpigenetic AlterationsIn addition, very little is known about the genetic and epigenetic profile of conjunctival melanoma and the resemblance to uveal, cutaneous and mucosal melanoma.27192168
Malignant melanoma of conjunctiva, melanomaEpigenetic AlterationsFinally, we wanted to identify tumour-specific and prognostic microRNAs in conjunctival melanoma, and to compare these with the microRNA expression of other melanoma subtypes.27192168
Malignant melanoma of conjunctivaEpigenetic AlterationsMicroRNA expression analysis revealed 25 tumour-specific microRNAs in conjunctival melanoma.27192168
NeoplasmsEpigenetic AlterationsSeven microRNAs (miR-30d-5p, miR-138-5p, miR-146a-5p, miR-500a-5p, miR-501-3p, miR-501-5p and miR-502-3p) were significantly and simultaneously up-regulated in both stage T1 and stage T2 tumours, and were associated with increased tumour thickness.27192168
Mucosal Melanoma, Malignant melanoma of conjunctivaEpigenetic AlterationsThe expression of the 25 tumour-specific microRNAs did not differ significantly between conjunctival melanoma and oral or nasal mucosal melanoma.27192168
Uveal melanoma, Mucosal Melanoma, Malignant melanoma of conjunctivaEpigenetic AlterationsFrom our findings of a distinct pattern of BRAF mutations and differentially expressed microRNAs, it is evident that conjunctival melanoma is closely related to cutaneous and other mucosal melanomas and bears less resemblance to uveal melanomas.27192168
Malignant melanoma of conjunctivaEpigenetic AlterationsAdditionally, the identification of several up-regulated microRNAs may prove to be useful as prognostic or therapeutic targets in conjunctival melanoma.27192168
Aortic Aneurysm, AbdominalEpigenetic AlterationsThe extent of DNA methylation in the AAA patients was negatively correlated with the corresponding aortic diameter (r = -0.498, p < 0.0001).27194055
Aortic Aneurysm, AbdominalEpigenetic AlterationsAbnormal Epigenetic Modifications in Peripheral T Cells from Patients with Abdominal Aortic Aneurysm Are Correlated with Disease Development.27194055
Non-Small Cell Lung CarcinomaEpigenetic AlterationsUpregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells.27195672
Metastasis, Primary malignant neoplasmEpigenetic AlterationsRecently, long non-coding RNAs (lncRNAs) are identified as new crucial regulators of diverse cellular processes, including cell proliferation, differentiation and cancer cells metastasis.27195672
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsLong intergenic noncoding RNAs (lincRNAs) have important roles in biological functions, molecular mechanisms and prognostic values in colorectal cancer (CRC).27195675
Prostate Cancer PathwayEpigenetic AlterationsImpact of Genetic and Epigenetic Variations Within the FADS Cluster on the Composition and Metabolism of Polyunsaturated Fatty Acids in Prostate Cancer.27197070
Deep thrombophlebitis, ThrombophiliaEpigenetic AlterationsIn conclusions, these findings indicate that certain miRNAs are associated with DVT and markers of hypercoagulability, though their diagnostic abilities are probably too low.27197074
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDistinct alterations in the DNA methylation of the gene regions encoding TGFb pathway components were detected in NSCLC samples compared with tumor-free lung tissues.27197161
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIn particular, epigenetic silencing of BAMBI was identified as a hallmark of NSCLC.27197161
NeoplasmsEpigenetic AlterationsColorectal tumor molecular phenotype and miRNA: expression profiles and prognosis.27198570
NeoplasmsEpigenetic AlterationsIn this paper, we test the hypotheses that miRNA expression differs by tumor molecular phenotype and that those differences may influence prognosis.27198570
NeoplasmsEpigenetic AlterationsWe assessed differences in miRNA expression between TP53-mutated and non-mutated, KRAS-mutated and non-mutated, BRAF-mutated and non-mutated, CpG island methylator phenotype (CIMP) high and CIMP low, and microsatellite instability (MSI) and microsatellite stable (MSS) colon and rectal tumors.27198570
NeoplasmsEpigenetic AlterationsIt has been proposed that unique miRNAs influence specific tumor molecular phenotype.27198570
NeoplasmsEpigenetic AlterationsAdditionally, 13 miRNAS were differentially expressed for KRAS-mutated rectal tumors, 8 differentially expressed miRNAs for colon CIMP high tumors, and 2 differentially expressed miRNAs for BRAF-mutated colon tumors.27198570
NeoplasmsEpigenetic AlterationsThe majority of differentially expressed miRNAS were observed between MSI and MSS tumors (94 differentially expressed miRNAs for colon; 41 differentially expressed miRNAs for rectal tumors).27198570
NeoplasmsEpigenetic AlterationsOf these miRNAs differentially expressed between MSI and MSS tumors, the majority were downregulated.27198570
NeoplasmsEpigenetic AlterationsIn summary, it appears that the majority of miRNAs that are differentially expressed by tumor molecular phenotype are MSI tumors.27198570
Benign Paroxysmal Positional VertigoEpigenetic AlterationsWe conclude that BPPV treatment might involve some epigenetic regulations through the mediation of miR-34a, SIRT1 functions and repression of redox status.27203679
Malignant neoplasm of urinary bladderEpigenetic AlterationsUp-regulation of long non-coding RNA PANDAR is associated with poor prognosis and promotes tumorigenesis in bladder cancer.27206339
Malignant NeoplasmsEpigenetic AlterationsPANDAR (promoter of CDKN1A antisense DNA damage activated RNA) is a novel long non-coding RNA that acts as a potential biomarker and involves in development of multiple cancers.27206339
NeoplasmsEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have emerged as biomarkers and important regulators of tumor development and progression.27206339
NeoplasmsEpigenetic AlterationsAccordingly, treatment of tumor cells with inhibitors of DNA methylation reversed resistance to PML-induced senescence.27206849
Primary malignant neoplasmEpigenetic AlterationsA CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence.27206849
NeoplasmsEpigenetic AlterationsTaken together, our findings highlight a potentially valuable feature of CDK4/6 inhibitors as epigenetic modulators to facilitate activation of senescence programs in tumor cells.27206849
Squamous cell carcinoma, SERPINB3 wt Allele, NeoplasmsEpigenetic AlterationsEvaluation of miRNA-expression and clinical tumour parameters in oral squamous cell carcinoma (OSCC).27210505
SERPINB3 wt Allele, NeoplasmsEpigenetic AlterationsmiRNA extraction from FFPE samples functioned well for OSCC, and several miRNAs were differently expressed in tumours compared with non-tumorous tissue (i.e., miR-99*; miR-224; miR-205*), indicating their possible utility as biomarkers.27210505
Prostate Cancer PathwayEpigenetic AlterationsDirect regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer.27212625
Hormone refractory prostate cancer, Primary malignant neoplasmEpigenetic AlterationsOur miRNA expression signature in castration-resistant prostate cancer (CRPC) revealed that microRNA-320a (miR-320a) was significantly reduced in cancer tissues, suggesting that miR-320a may be a promising anticancer miRNA.27212625
Admitting diagnosisEpigenetic AlterationsOur data implicate dysregulation of miRNA methylation as contributor to the pathogenesis of AD.27213057
melanoma, NeoplasmsEpigenetic AlterationsOf special interest in our series is the high incidence of male predominance (79%) in cases of thin metastasing melanoma (14%), implicating genetic or epigenetic (hormonal) gender differences underlying tumour progression.27213536
Pulmonary arterial hypertensionEpigenetic AlterationsMicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.27214554
Carcinogenesis, Glioblastoma Multiforme PathwayEpigenetic AlterationsAs a class of small non-coding RNAs, microRNAs (miRNAs) may be closely involved in carcinogenesis and might also be connected with glioma diagnosis and prognosis.27215622
ovarian neoplasmEpigenetic AlterationsEpigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution.27216078
CarcinogenesisEpigenetic AlterationsThe exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear.27216078
CarcinogenesisEpigenetic AlterationsEpigenetic reprogramming is an early pre-malignant event integral to BRCA1/2 mutation-driven carcinogenesis.27216078
Carcinoma, Transitional Cell, Kidney DiseasesEpigenetic AlterationsMicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy.27218105
Malignant NeoplasmsEpigenetic AlterationsAberrantly expressed miRNAs have been shown to be associated with many types of cancers.27218105
FailureEpigenetic AlterationsEpigenetic silencing of GSTM2 and MYCL2 comprise novel molecular markers to predict BCR after surgery for medium- and high-risk localized PCa undergoing surgical treatment and hypermethylation of these genes could be incorporated to the clinical and pathological factors defining the patient at higher risk of PSA failure after prostatectomy.27220660
Huntington DiseaseEpigenetic AlterationsAltered Expression of the Long Noncoding RNA NEAT1 in Huntingtons Disease.27221610
Hodgkin Disease, neuron deathEpigenetic AlterationsGrowing evidence supports the regulatory functions of long noncoding RNAs (lncRNAs) in the disease process, but little is known about the association between lncRNAs and neuronal death in HD.27221610
Breast CarcinomaEpigenetic AlterationsCirculating Cell-free miRNA Expression and its Association with Clinicopathologic Features in Inflammatory and Non- Inflammatory Breast Cancer.27221856
Primary malignant neoplasmEpigenetic AlterationsPolymorphisms affecting microRNA (miRNA) biogenesis or mRNA:miRNA interactions are important risk factors in the development of different types of cancer.27221928
Metastasis, NeoplasmsEpigenetic AlterationsSeveral long non-coding RNAs (lncRNAs) have been identified that may have a crucial role in tumor progression and metastasis.27222255
Renal Cell Carcinoma PathwayEpigenetic AlterationsDownregulation of lncRNA CASC2 by microRNA-21 increases the proliferation and migration of renal cell carcinoma cells.27222255
Refractory Cytopenia of ChildhoodEpigenetic AlterationsMicroRNA-21 (miR-21) has been reported to be upregulated in human RCC tissues and cell lines, and is associated with the malignant progression of RCC.27222255
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsAlthough the role of traditional risk factors for type 2 diabetes, such as genetic, lifestyle, and behavioral risk factors, has been given attention, recent research has focused on identifying the contributions of epigenetic mechanisms and the effect of the intrauterine environment.27222545
NeoplasmsEpigenetic AlterationsMicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1.27223073
Malignant Neoplasms, MetastasisEpigenetic AlterationsMicroRNA (miR)-138 was found to have suppressive effects on the growth and metastasis of different human cancers.27223073
Sarcoma, Sarcoma, EpithelioidEpigenetic AlterationsEpigenetic regulation of SMARCB1 By miR-206, -381 and -671-5p is evident in a variety of SMARCB1 immunonegative soft tissue sarcomas, while miR-765 appears specific for epithelioid sarcoma.27223121
NeoplasmsEpigenetic AlterationsA subset of ESs (5/51) showed biallelic deletion of SMARCB1 with no overexpression of any miRNA, suggesting these tumors could be the counterpart of pediatric RT, at least genetically.27223121
Adenocarcinoma, NeoplasmsEpigenetic AlterationsGene and MicroRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated With Preoperative Chemoradiotherapy.27225591
SepticemiaEpigenetic AlterationsDiagnostic value of elevated serum miRNA-143 levels in sepsis.27225861
SRC geneEpigenetic AlterationsFurthermore, bFGF inhibited microRNA-381 expression via the PDGFR and c-Src cascade.27229532
Malignancy-associated membranous nephropathy, Breast CarcinomaEpigenetic AlterationsThe potential of identification of a malignancy-associated biomarker in breast cancer diagnosis and research: hTERT gene DNA methylation.27229911
Carcinoma of lungEpigenetic AlterationsAssociations between genetic variants located in mature microRNAs and risk of lung cancer.27232940
Colorectal Cancer Pathway, HLA Mismatch, MLH1 geneEpigenetic AlterationsAssociation of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC).27234654
MLH1 geneEpigenetic Alterationsrs868 is contained in a let-7 miRNA binding site in the 3UTR of TGFBR1, which might provide a functional basis for the association in MSS HNPCC.27234654
Multiple MyelomaEpigenetic AlterationsEpigenetic dysregulation is known to be an important contributor to myeloma pathogenesis but, unlike other B-cell malignancies, the full spectrum of somatic mutations in epigenetic modifiers has not been reported previously.27235425
Multiple MyelomaEpigenetic AlterationsNumerous mutations identified raise the possibility of targeted treatment strategies for patients either at diagnosis or relapse supporting the use of sequencing-based diagnostics in myeloma to help guide therapy as more epigenetic targeted agents become available.27235425
Breast CarcinomaEpigenetic AlterationsThe dysregulation of miRNA expression has frequently been observed in breast cancer.27236032
Breast CarcinomaEpigenetic AlterationsExpression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer.27236032
Breast CarcinomaEpigenetic AlterationsThe expression levels of the miRNAs and FHIT were downregulated in breast cancer tissue.27236032
Malignant NeoplasmsEpigenetic AlterationsOur data suggest that VWF:Ag could be a circulating biomarker of disease malignancy, that could be considered, in association with other genetic and epigenetic factors, currently available in the GBM management.27236861
Cessation of lifeEpigenetic AlterationsEffect of microRNA-21 on the proliferation of human degenerated nucleus pulposus by targeting programmed cell death 4.27240294
Colorectal Cancer PathwayEpigenetic AlterationsAberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer.27245242
Carcinogenesis, AdenomaEpigenetic AlterationsAberrant DNA methylation appears already in adenomas as an early event of colorectal carcinogenesis.27245242
CarcinogenesisEpigenetic AlterationsThe WNT signaling pathway has an essential role in colorectal carcinogenesis and progression, which involves a cascade of genetic and epigenetic changes.27245242
Stomach CarcinomaEpigenetic AlterationsLong noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression.27246976
Malignant Neoplasms, Stomach Carcinoma, DiseaseEpigenetic AlterationsRecently, long noncoding RNAs have been emerged as critical regulators of human disease and prognostic markers in several cancers, including gastric cancer.27246976
NeoplasmsEpigenetic AlterationsOur results propose that HSP60 silencing disrupts the integrity of the respiratory complex I and triggers the excessive ROS production, which promotes tumor progression in the following aspects: (1) ROS activates the AMPK pathway that promotes acquisition of the Warburg phenotype in HSP60-KN cells; (2) ROS generated by HSP60 knockdown or by rotenone inhibition drives cells to undergo EMT; and (3) the high level of ROS may also fragment the Fe-S clusters that up regulates ADHFe1 expression and the 2-hydroxygluterate (2-HG) production leading to changes in DNA methylation.27246978
Stage II Colon Cancer AJCC v7Epigenetic AlterationsIdentifying High-Risk Stage II Colon Cancer Patients: A Three-MicroRNA-Based Score as a Prognostic Biomarker.27247088
Malignant tumor of colonEpigenetic AlterationsOur 3-miRNA score added valuable prognostic information to the clinical features in stage II colon cancer.27247088
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) have previously been shown to be useful cancer biomarkers.27247088
Degenerative polyarthritisEpigenetic AlterationsPreviously, it was reported that the inhibition of microRNA-34a (miR-34a) may reduce rat chondrocyte apoptosis induced by IL-1b, whereas the molecular mechanism and the role of miR-34a in human chondrocyte as well as in OA progression remains to be determined.27247228
Leukemia, Myelocytic, AcuteEpigenetic AlterationsClinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations.27247325
Leukemia, Myelocytic, AcuteEpigenetic AlterationsIn recent years, it has been reported that the frequency of DNA-methylation regulatory gene mutations - mutations of the genes that regulate gene expression through DNA methylation - is high in acute myeloid leukemia.27247325
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAcute myeloid leukemia associated with a DNA-methylation regulatory gene mutation was more frequent in older patients (P<0.0001) and in patients with intermediate cytogenetic risk (P<0.0001) accompanied by a high white blood cell count (P=0.0032).27247325
Liver carcinomaEpigenetic AlterationsComparison of genome-scale DNA methylation profiles in hepatocellular carcinoma by viral status.27248055
Communicable Diseases, Hepatitis B, Hepatitis C, Hollings Cancer CenterEpigenetic AlterationsOur understanding of epigenetic regulation in HCC is still limited, especially the impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on aberrant DNA methylation.27248055
Virus Diseases, Hollings Cancer CenterEpigenetic AlterationsOur findings of differential methylation by viral infection lend insights into the potential effects of viral infection on the epigenetic regulation and further the development and progression of HCC.27248055
Primary malignant neoplasmEpigenetic AlterationsmicroRNAs (miRNAs) play critical roles in cancer development and progression.27248318
NeoplasmsEpigenetic AlterationsTumors were considered to harbor active TAZ/YAP-driven gene transcription when they co-expressed TAZ, or YAP, and CTGF.27248471
CarcinogenesisEpigenetic AlterationsThe majority of studies to date focused on genetic mutations and epigenetic changes that drive the CRC carcinogenesis process.27253631
CarcinogenesisEpigenetic AlterationsThe restoration of ABCG2 function via modulating this new microRNA-methylation mechanism in precancerous cells may represent an attractive strategy to delay the carcinogenesis process.27253631
NeoplasmsEpigenetic AlterationsOne of these miRNA, miR-187, was significantly decreased in pre-treatment EAC tumors from patients having a poor response to neoadjuvant CRT, highlighting downregulation of miR-187 as a potential mechanism of treatment resistance in EAC.27254108
Right armEpigenetic AlterationsMicroRNA-125b negatively regulates expression of TNF-a, which plays a crucial role in RA pathogenesis.27255643
Rheumatoid Arthritis, Right armEpigenetic AlterationsIt was proved that some miRNAs are significantly deregulated in rheumatoid arthritis (RA).27255643
Loss of Chromosome 22qEpigenetic AlterationsThe recurrent loss of chromosome 22q appeared to contribute to this phenomenon by promoting the expression of epigenetic regulators, such as EZH2.27256159
GliomaEpigenetic AlterationsWe conclude that deregulation of CPEB proteins may be a frequent phenomenon in gliomas and occurs on the level of transcription involving epigenetic mechanism as well as on the level of mRNA splicing, which generates isoforms with compromised biological properties.27256982
DICER1 protein, humanEpigenetic AlterationsDicer is an RNase III enzyme responsible for cleaving double-stranded RNAs into small interfering RNAs and microRNAs, which either target messenger RNA transcripts for degradation or inhibit translation.27260947
Diabetes Mellitus, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsSerum microRNA-196 and microRNA-200 in pancreatic ductal adenocarcinoma of patients with diabetes mellitus.27267055
Weight decreasedEpigenetic AlterationsMicroRNA-200 was significantly higher in PAC patients with significant body weight loss against those without weight loss.27267055
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsAlthough increasing evidence demonstrated that deregulation of mircoRNA-503 (miRNA-503) contributes to tumorigenesis, little is known about the biological role and intrinsic regulatory mechanisms of miR-503 in prostate cancer (PCa).27267060
Stomach CarcinomaEpigenetic AlterationsSingle nucleotide polymorphisms in miRNA-coding region may be involved in the development or progression of gastric cancer (GC).27267319
Primary malignant neoplasmEpigenetic AlterationsWhile lncRNAs (long noncoding RNAs) have been shown to have critical regulatory roles in cancer biology, the biological functions and prognostic values in nonmuscle invasive bladder cancer remain largely unknown.27267320
Colorectal Cancer PathwayEpigenetic AlterationsWe sought evidence for an association between the rs16906252C>T genotype and increased risk of developing a subtype of colorectal cancer featuring MGMT methylation, mediated by genotype-dependent epigenetic silencing within normal tissues.27267851
Colorectal Cancer PathwayEpigenetic AlterationsWe provide evidence that rs16906252C>T is associated with elevated risk for MGMT-methylated colorectal cancer, likely mediated by constitutive epigenetic repression of the T allele.27267851
Glioblastoma Multiforme PathwayEpigenetic AlterationsHowever, potential mechanisms between lncRNAs and miRNAs in glioma remain largely unknown.27267902
NeoplasmsEpigenetic AlterationsmicroRNAs (small non-coding RNAs) have proven to be effective biomarkers for the identification of tumors and tumor progression.27267924
Chondrosarcoma, NeoplasmsEpigenetic AlterationsThe data suggest these microRNAs would provide an analytical distinction between the chondrosarcoma and benign neoplasms that can be performed in formalin-fixed paraffin-embedded specimens.27267924
Hereditary Breast and Ovarian Cancer Syndrome, Hereditary DiseasesEpigenetic AlterationsOf individuals with suspected hereditary breast and ovarian cancer (HBOC), approximately 30-70 % do not harbor mutations in either BRCA1 or BRCA2 gene, which suggests that these individuals have other genetic or epigenetic alterations that could lead to the onset of this hereditary disease.27271530
ovarian neoplasmEpigenetic AlterationsFurther studies are needed to clarify whether other mutations/epigenetic alterations are involved in the pathogenesis of BRCA1 or BRCA2 mutation-negative inherited disease with breast or ovarian cancer.27271530
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer.27271609
Clinical CoordinatorEpigenetic AlterationsInhibition of DNA methylation recovered FOXE1 expression in CRC cells.27271927
Hepatitis C, Liver carcinomaEpigenetic AlterationsSerum microRNA panels as potential biomarkers for early detection of hepatocellular carcinoma on top of HCV infection.27271989
Liquid Chromatography, Hollings Cancer CenterEpigenetic AlterationsUsing miRNA panel of miR-122, miR-885-5p, and miR-29b with alpha fetoprotein (AFP) provided high diagnostic accuracy (AUC = 1) for early detection of HCC in normal population while using miRNA panel of miR-122, miR-885-5p, miR-221, and miR-22 with AFP provided high diagnostic accuracy (AUC = 0.982) for early detection of HCC in LC patients.27271989
Carcinogenic Chlorinated Hydrocarbon, Hollings Cancer CenterEpigenetic AlterationsHowever, using miRNA panel of miR-22 and miR-199a-3p with AFP provided high diagnostic accuracy (AUC = 0.988) for early detection of HCC in CHC patients.27271989
Hollings Cancer CenterEpigenetic AlterationsWe identified serum miRNA panels that could have a considerable clinical use in early detection of HCC in both normal population and high-risk patients.27271989
Communicable Diseases, Hepatitis C, Hollings Cancer CenterEpigenetic AlterationsWe aimed at identifying serum microRNAs (miRNAs) as potential biomarkers for early detection of HCC on top hepatitis C virus (HCV) infection.27271989
Primary malignant neoplasmEpigenetic AlterationsEpigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort.27274774
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-320 was downregulated in non-small cell lung cancer and inhibited cell proliferation, migration and invasion by targeting fatty acid synthase.27277534
NeoplasmsEpigenetic AlterationsMicro ribonucleic acid (RNA)-93 (miR-93) is a novel oncogenic miRNA dysregulated in many types of tumors.27279231
PeriodontitisEpigenetic AlterationsDNA methylation of the cytokine genes may play a role in the pathogenesis of periodontitis.27280944
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsCirculating microRNAs in patients with ST-elevation myocardial infarction.27282672
NSD1 protein, human, CHEK2 geneEpigenetic AlterationsNew somatic alterations were identified in oncogenes (MDM2, FLI1), transcription factors and repressors (MITF, FLI1, ZNF331), epigenetic enzymes (KMT2A, NSD1, NCOA1, NCOA2), and protein kinases (JAK3, CHEK2, ALK).27283500
cervical cancerEpigenetic AlterationsMicroRNA-218 inhibits EMT, migration and invasion by targeting SFMBT1 and DCUN1D1 in cervical cancer.27285984
cervical cancer, Primary malignant neoplasmEpigenetic AlterationsHere, we reported that miR-218 (microRNA-218) was downregulated in cervical cancer tissues, especially in metastatic cancer tissues.27285984
Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsMicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4.27286257
Clinical CoordinatorEpigenetic AlterationsFive miRNA target prediction programs were applied to identify potential miRNA(s) that target(s) Smad4 in CRC.27286257
Clinical Coordinator, Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsmiR-20a-5p, as an onco-miRNA, promoted the invasion and metastasis ability by suppressing Smad4 expression in CRC cells, and high miR-20a-5p predicted poor prognosis for CRC patients, providing a novel and promising therapeutic target in human colorectal cancer.27286257
Primary malignant neoplasmEpigenetic AlterationsMechanistically, LPS stimulation increased expression levels of microRNA-21 (miR-21) in primary human lung cancer cells.27286259
Carcinoma of lung, NeoplasmsEpigenetic AlterationsTLR4/ROS/miRNA-21 pathway underlies lipopolysaccharide instructed primary tumor outgrowth in lung cancer patients.27286259
Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsDownregulation of long non-coding RNA ANRIL suppresses lymphangiogenesis and lymphatic metastasis in colorectal cancer.27286457
ABCB1 wt AlleleEpigenetic AlterationsHowever, frequent simultaneous methylation of the studied genes in more than 50 % of NSCLCs suggests the possibility of consider them as a panel of epigenetic markers.27287342
Recombinant Interferon-gammaEpigenetic AlterationsIncreasing levels of microRNA (miRNA)-21 can lead to IFN-g deficiency, thereby suppressing immune function.27288814
Cerebrovascular accidentEpigenetic AlterationsThe stroke with SAI group had significantly higher miRNA-21 expression and lower IFN-g levels than the stroke without SAI group (p<0.05).27288814
Acute Cerebrovascular AccidentsEpigenetic AlterationsPlasma up-regulated miRNA-21 and decreased IFN-g in acute stroke can be considered new biological predictors for SAI and thus, new therapeutic targets.27288814
Heart failure, InflammationEpigenetic AlterationsA set of six microRNAs implicated in inflammation (miR-155 and miR-146b), heart failure (miR-21 and miR-133a), and endothelial cell (miR-126) and skeletal muscle function (miR-206) was pre-defined.27292200
Carcinoma, Transitional CellEpigenetic AlterationsWe found microRNA-133b (miR-133b) was downregulated in urothelial carcinoma of the bladder (UCB) tissues, and it could inhibit the proliferation and induce apoptosis in UCB cells.27292588
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) represent an emerging layer of cancer biology and have been implicated in the development and progression of cancers.27292966
Breast CarcinomaEpigenetic AlterationsDecreased Expression of Bioinformatically Predicted piwil2-targetting microRNAs, miR-1267 and miR-2276 in Breast Cancer.27293058
Breast CarcinomaEpigenetic AlterationsConsidering the vital role of microRNAs (miRNAs) in regulating the expression of most human genes, we hypothesized a concomitant downregulation of the bioinformatically-predicted piwil2-targetting microRNAs in breast cancer.27293058
Pulmonary Complication, Cessation of lifeEpigenetic AlterationsHigh miRNA-21 was also associated with an increased risk of extrapulmonary complications (OR, 3.62; 95% CI, 2.26-5.81; and P < 0.001), prolonged ICU stay (OR, 6.54; 95% CI, 2.26-18.19; and P < 0.001), increased death within 30 days (OR, 6.17; 95% CI, 2.11-18.08; and P < 0.001), and death within 1 year (OR, 7.30; 95% CI, 2.76-19.28; and P < 0.001).27293316
Colorectal Cancer PathwayEpigenetic AlterationsClinical stage and risk of recurrence and mortality: interaction of DNA methylation factors in patients with colorectal cancer.27296458
Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation plays a crucial role in cancer development; however, prospective evidence of an interaction between molecular biomarkers and cancer staging for predicting the prognosis of colorectal cancer (CRC) is still limited.27296458
Clinical Coordinator, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsWe examined DNA methylation in tumors and adjacent normal tissues from patients who underwent CRC surgical resection, and evaluated the interaction between cancer staging (advanced vs local) and DNA methylation to predict the prognosis of CRC.27296458
Clinical CoordinatorEpigenetic AlterationsDNA methylation status would significantly increase the recurrence risk of CRC with a significant impact on joint effect between DNA methylation and clinical stage, particularly in matched normal tissues.27296458
NeoplasmsEpigenetic AlterationsThis study showed that circRNAs are differentially expressed in cSCC and play an important role in tumor formation by interfering with cSCC relevant miRNAs through miRNA sequence complementary MREs participating in epigenetic control.27298156
Hollings Cancer CenterEpigenetic AlterationsmiRNA array screening showed that miR-106b and its cluster, miR-93 and miR-25 were up-regulated in HCC patients (P < 0.01).27298561
Malignant tumor of colonEpigenetic AlterationsTo detect the expression of the long noncoding RNA HOTAIR in colon cancer and analyze its relationship with clinicopathological parameters of colon cancer.27298568
Glaucoma, CTCAEEpigenetic AlterationsIncreased Global DNA Methylation and Decreased TGFb1 Promoter Methylation in Glaucomatous Lamina Cribrosa Cells.27300643
Glaucoma, CTCAE, Fibrosis AssessmentEpigenetic AlterationsDNA methylation is well established in regulating fibrosis and may be a therapeutic target for glaucoma.27300643
Liver carcinomaEpigenetic AlterationsThe long noncoding RNA HOTAIR activates autophagy by upregulating ATG3 and ATG7 in hepatocellular carcinoma.27301338
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsThe long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been reported to be an oncogene that influences tumor cell development and that correlates with prognosis in hepatocellular carcinoma (HCC).27301338
Chronic Lymphocytic LeukemiaEpigenetic AlterationsPhenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming.27302925
Chronic Lymphocytic LeukemiaEpigenetic AlterationsTaken together, our findings reveal the occurrence of epigenetic reprogramming taking place within CLL patient CD8+ T cells and highlight the potential mechanism of how immunosuppression is accomplished in CLL.27302925
Endometrial CarcinomaEpigenetic AlterationsDNA methylation and DNA methyltransferase (DNMT1) activity pattern in endometrial carcinoma.27306462
Atypical Reparative CellEpigenetic AlterationsThe study supports the notion that the epigenetic modification of macromolecules in LECs might contribute to ARC pathogenesis.27306760
NeoplasmsEpigenetic AlterationsRecent studies have revealed many different long noncoding RNAs (lncRNA), however, the investigation for their function and clinical value as tumour biomarkers has scarcely begun.27307307
Coronary Artery DiseaseEpigenetic AlterationsMicroRNAs (miRNAs) are involved in the pathogenesis of coronary artery disease (CAD).27313333
Breast Cancer CellEpigenetic AlterationsAntisense noncoding RNA in the INK4 locus (ANRIL) has been reported to be upregulated in various types of human cancer, and is also highly expressed in normal human tissue.27314206
Heart failureEpigenetic AlterationsLong noncoding RNA dysregulation in ischemic heart failure.27317124
Degenerative polyarthritisEpigenetic AlterationsMicroRNA-23a-3p promotes the development of osteoarthritis by directly targeting SMAD3 in chondrocytes.27318087
Septicemia, Systemic Inflammatory Response SyndromeEpigenetic AlterationsCirculating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS).27320175
InflammationEpigenetic AlterationsMicroRNAs regulate cellular processes including inflammation and may be detected in blood.27320175
Systemic Inflammatory Response SyndromeEpigenetic AlterationsDetectable blood miRNAs (n = 116) were generally up-regulated in SIRS compared to no-SIRS patients.27320175
Septicemia, Systemic Inflammatory Response SyndromeEpigenetic AlterationsSix CIR-miRNAs (miR-30d-5p, miR-30a-5p, miR-192-5p, miR-26a-5p, miR-23a-5p, miR-191-5p) provided good-to-excellent discrimination of severe sepsis from severe SIRS (0.742-0.917 AUC of ROC curves).27320175
InflammationEpigenetic AlterationsCIR-miRNAs may be regulators of inflammation and warrant thorough evaluation as diagnostic and therapeutic targets.27320175
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer.27322075
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis.27322206
Pancreatic carcinomaEpigenetic AlterationsThese results connect miR-1291 to the FOXA2-AGR2 regulatory pathway in the suppression of pancreatic cancer cell proliferation and tumorigenesis, providing new insight into the development of miRNA-based therapy to combat pancreatic cancer.27322206
Carcinoma of lung, Malignant neoplasm of lungEpigenetic AlterationsHere, we screened for abnormal long noncoding RNAs (lncRNAs) in lung cancers from patients living in Xuanwei city which has the highest lung cancer incidence in China due to smoky coal combustion-generated air pollution.27322209
Hollings Cancer CenterEpigenetic AlterationsThe let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC.27323017
Squamous cell carcinoma of esophagusEpigenetic AlterationsMicroRNAs (miRNAs) are key regulators of gene expression and play an important role in the development and progression of various diseases including esophageal squamous cell carcinoma (ESCC).27323028
Squamous cell carcinoma of the head and neckEpigenetic AlterationsWe also observed widespread ncRNA correlation to concurrent TP53 and chromosome 3p loss, a compelling predictor of poor prognosis in HNSCCs.27323410
NeoplasmsEpigenetic AlterationsMicroRNAs are involved in tumor initiation and progression by regulating oncogenes and tumor suppressor genes.27323412
Renal Cell Carcinoma PathwayEpigenetic AlterationsDownregulation of the long noncoding RNA TUG1 inhibits the proliferation, migration, invasion and promotes apoptosis of renal cell carcinoma.27323757
Colorectal Cancer PathwayEpigenetic AlterationsExploration of the interplay between specific miRNAs and genes, which are critically involved in the functioning of the biological clock, provides a better understanding of the importance of the miRNA-clock genes axis and its derangement in colorectal cancer.27323779
MetastasisEpigenetic AlterationsLong noncoding RNAs (lncRNAs) play critical roles in diverse biological processes such as tumorigenesis and metastasis.27329359
Carcinoma, Transitional Cell, NeoplasmsEpigenetic AlterationsHuman urothelial carcinoma associated 1 (UCA1) is a long noncoding RNA that is putatively oncogenic in solid tumors.27329842
Sjogrens SyndromeEpigenetic AlterationsEpigenetic Signatures of Salivary Gland Inflammation in Sjogrens Syndrome.27332624
cervical cancerEpigenetic AlterationsGenetic variants within microRNA-binding site of RAD51B are associated with risk of cervical cancer in Chinese women.27334422
Malignant Neoplasms, cervical cancerEpigenetic AlterationsIn summary, our study suggested that miRNA-binding site genetic variants of RAD51B may modify the susceptibility to cervical cancer, which is important to identify individuals with differential risk for this malignancy and to improve the effectiveness of preventive intervention.27334422
Carcinogenesis, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are frequently dysregulated in tumors, play a crucial role during carcinogenesis and therefore might be promising new biomarkers.27336447
Breast CarcinomaEpigenetic AlterationsTranscriptome sequencing uncovers a three-long noncoding RNA signature in predicting breast cancer survival.27338266
Breast CarcinomaEpigenetic AlterationsIn addition, lncRNA, miRNA, and mRNA interaction network indicated lncRNAs may intervene in breast cancer pathogenesis by binding to miR-190b, acting as competing endogenous RNAs.27338266
Squamous cell carcinoma of esophagusEpigenetic AlterationsAberrant methylation-mediated downregulation of long noncoding RNA LOC100130476 correlates with malignant progression of esophageal squamous cell carcinoma.27338851
Disease, Primary malignant neoplasmEpigenetic AlterationsDysregulated long non-coding RNAs (lncRNAs) are involved in many complicated human diseases including cancer.27338851
Primary MyelofibrosisEpigenetic AlterationsA data-driven network model of primary myelofibrosis: transcriptional and post-transcriptional alterations in CD34+ cells.27341078
Metastasis, Glioblastoma Multiforme PathwayEpigenetic AlterationsTP53INP1 3-UTR functions as a ceRNA in repressing the metastasis of glioma cells by regulating miRNA activity.27341836
Glioblastoma Multiforme PathwayEpigenetic AlterationsMoreover, TP53INP1 3-UTR inhibited glioma cell proliferation, invasion and proliferation; Furthermore, the 3-UTRs of TP53INP1 and E-cadherin harboured seven identical miRNAs binding sites, and TP53INP1 3-UTR could increase the expression of E-cadherin and decrease the expression of vimentin thus repressing the epithelial-mesenchymal transition (EMT).27341836
cervical cancerEpigenetic AlterationsmiRNA-145 and 9 may be as potential prognostic marker in patients suffering from cervical cancer.27345415
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) may act as carcinogen or tumor suppressor genes by targeting various biological molecules.27345415
cervical cancerEpigenetic AlterationsmiRNAs expression was detected using quantitative real-time polymerase chain reaction in cervical cancer specimens and adjacent normal tissues.27345415
Squamous cell carcinoma of esophagusEpigenetic AlterationsPlasma miRNA-506 as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma.27345473
NeoplasmsEpigenetic AlterationsmiRNA-506 is abnormally expressed in multiple tumors, indicating that it might be oncogenic or tumor-suppressive.27345473
Squamous cell carcinoma of esophagusEpigenetic AlterationsHowever, little is known about the association between miRNA-506 expression and esophageal squamous cell carcinoma (ESCC).27345473
Squamous cell carcinoma of esophagusEpigenetic AlterationsROC curves were produced for ESCC diagnosis by plasma miRNA-506 and the area under curve was calculated to explore its diagnostic value.27345473
Squamous cell carcinoma of esophagusEpigenetic AlterationsRESULTS Average miRNA-506 expression levels were remarkably higher in the plasma of ESCC patients than in healthy volunteers (P<0.001).27345473
Tetranitromethane, NeoplasmsEpigenetic AlterationsThe expression of miRNA-506 in the plasma was closely associated with lymph node status (P=0.004), TNM stage (P=0.031), and tumor length (P<0.001).27345473
Squamous cell carcinoma of esophagusEpigenetic AlterationsAccording to ROC curves, the area under the curve for plasma miRNA-506 was 0.835, indicating statistical significance for ESCC diagnosis by plasma miRNA-506 (P<0.001).27345473
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsCox regression analysis demonstrated that T stage, N stage, tumor length, and miRNA-506 expression levels were significantly correlated with prognosis in ESCC patients.27345473
Squamous cell carcinoma of esophagusEpigenetic AlterationsCONCLUSIONS miRNA-506 can serve as an important molecular marker for diagnosis and prognostic prediction of ESCC.27345473
Metastasis, NeoplasmsEpigenetic AlterationsBACKGROUND MicroRNAs (miRNAs) are responsible for regulating proliferation, differentiation, apoptosis, invasion, and metastasis in tumor cells.27345473
Acute Coronary SyndromeEpigenetic AlterationsSerum miRNA-499 and miRNA-210: A potential role in early diagnosis of acute coronary syndrome.27346801
CO-methylating acetyl-CoA synthase activityEpigenetic AlterationsBoth miRNAs might be potentially novel biomarkers for accelerating the diagnosis of ACS patients in emergency unit.27346801
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsWe assessed plasma microRNA-21 levels in patients with colorectal cancer (CRC) at different stages and in patients with benign polyps.27349026
Primary malignant neoplasmEpigenetic AlterationsRecent evidence suggests that microRNAs play an important role in cancer diagnostics.27349026
Chronic painEpigenetic AlterationsMicroRNAs (miRNA) can regulate both immune and neuronal processes and may function as master switches in chronic pain development and maintenance.27349406
Feel PainEpigenetic AlterationsSubsequently, miR-132-3p expression was pharmacologically modulated with miRNA antagonists or mimetics, and evoked pain and pain aversion were assessed.27349406
diabeticEpigenetic AlterationsHere, we show that miR-93 is a critical metabolic/epigenetic switch in the diabetic milieu linking the metabolic state to chromatin remodelling.27350436
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLong non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway.27351135
Primary malignant neoplasmEpigenetic AlterationsRecently, the long non-coding RNA (lncRNA) NEAT1 has been identified as an oncogenic gene in multiple cancer types and elevated expression of NEAT1 was tightly linked to tumorigenesis and cancer progression.27351135
Non-Small Cell Lung CarcinomaEpigenetic AlterationsTaken together, these observations imply that the NEAT1 modulated the expression of E2F3 gene by acting as a ceRNA, which may build up the missing link between the regulatory miRNA network and NSCLC progression.27351135
Primary malignant neoplasmEpigenetic AlterationsProspective changes in global DNA methylation and cancer incidence and mortality.27351216
Peripheral Vascular DiseasesEpigenetic AlterationsAmong these miRNAs, we identified miR-21 as a candidate fibrotic miRNA with an important role in the pathogenesis of PVD.27351379
Retinal fibrosis, Vitreous humor, Peripheral Vascular DiseasesEpigenetic AlterationsTogether, our studies have identified miR-21 as a potential disease-modifying miRNA in the vitreous humor that is involved in the development of retinal fibrosis and may be a novel marker of PVD.27351379
Vitreoretinal Area, Vitreous humorEpigenetic AlterationsAberrant expression of miRNAs in the vitreous humor of vitreoretinal diseased eyes has been reported.27351379
Fibrosis Assessment, Peripheral Vascular DiseasesEpigenetic AlterationsThe expression of a specific subset of miRNAs, previously reported to be associated with the development of angiogenesis and fibrosis, was significantly altered in the vitreous of PVD patients.27351379
Malignant tumor of colonEpigenetic AlterationsDistinct Transcriptional Changes and Epithelial-Stromal Interactions Are Altered in Early-Stage Colon Cancer Development.27353028
Neuroendocrine TumorsEpigenetic AlterationsMicroRNAs associated with small bowel neuroendocrine tumours and their metastases.27353039
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-140 Inhibits Cell Proliferation in Gastric Cancer Cell Line HGC-27 by Suppressing SOX4.27353653
Stomach CarcinomaEpigenetic AlterationsMicroRNAs are important regulators of gene expression, influencing the progression of gastric cancer.27353653
Metabolic Syndrome XEpigenetic AlterationsCirculating MicroRNA-21 is Downregulated in Patients with Metabolic Syndrome.27353714
Primary malignant neoplasmEpigenetic AlterationsThe microRNA-21 (miR-21) is known to play a major role in cancer progression; however, its function in the cardiovascular system appears to be even more complex and conflicting.27353714
Colorectal Cancer PathwayEpigenetic AlterationsImpact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer.27354594
Clinical CoordinatorEpigenetic AlterationsDOK3 rs2279398G>A may affect the expression of DOK3 by altering the miRNA binding efficiency at the miRNA-binding sites of the 3-UTR in DOK3, thereby impacting CRC tumorigenesis.27354594
Autoimmune DiseasesEpigenetic AlterationsAdditionally, disorders of epigenetic processes, in particular non-random X chromosome inactivation (XCI), have been reported in many female-predominant autoimmune diseases.27355582
Hippocampal atrophy, "Alzheimers Disease", Amnesia, CTCAE, Impaired cognitionEpigenetic AlterationsDNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy in Alzheimers disease and amnesic mild cognitive impairment patients.27356276
Impaired cognition, Admitting diagnosis, Amnesia, CTCAEEpigenetic AlterationsWe have already reported that DNA methylation levels in the NCAPH2/LMF2 promoter region can be a useful biomarker for the diagnosis of AD and amnesic mild cognitive impairment (aMCI).27356276
Hippocampal atrophyEpigenetic AlterationsOur results suggest that DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy through apoptosis.27356276
Uveal melanomaEpigenetic AlterationsOncogenic role of microRNA-20a in human uveal melanoma.27356499
MIR20A gene, Primary malignant neoplasmEpigenetic AlterationsAs a member of the microRNA (miR)-17-92 cluster, miR-20a has been indicated to be involved in the regulation of the proliferation and invasion of various cancer cells.27356499
MIR20A geneEpigenetic AlterationsThese data provided convincing evidence that miR-20a may function as an oncogenic miRNA, and may be involved in promoting cell growth and motility in the molecular etiology of UM, suggesting its potential as a candidate therapeutic target for the treatment of patients with UM.27356499
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA-335 inhibits bladder cancer cell growth and migration by targeting mitogen-activated protein kinase 1.27356628
CO-methylating acetyl-CoA synthase activity, Acute Coronary SyndromeEpigenetic AlterationsRecently, we identified eight microRNAs (miRNAs), which facilitated acute coronary syndrome (ACS) diagnosis.27357355
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe dysregulation of microRNAs (miRNAs) has been demonstrated to contribute to drug resistance of cancer cells, and sustained nuclear factor (NF)kB activation is also pivotal in tumor resistance to chemotherapy.27357419
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHere, we describe for the first time a comprehensive characterization of miRNA expression in human fetal lung tissue, with subsequent identification of 37 miRNAs in non-small cell lung cancer (NSCLC) that recapitulate their fetal expression patterns.27357447
Aggressive behavior, Adenocarcinoma of lung (disorder)Epigenetic AlterationsDevelopmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma.27357447
Non-Small Cell Lung CarcinomaEpigenetic AlterationsInterrogation of NFIB copy number, methylation, and mutation status revealed that DNA level disruption of this gene is rare, and further supports the notion that oncofetal miRNAs are likely the primary mechanism responsible for NFIB underexpression in NSCLC.27357447
CarcinogenesisEpigenetic AlterationsDysregulation of microRNAs (miRNAs) have been demonstrated to contribute to carcinogenesis.27358073
Prostate Cancer PathwayEpigenetic AlterationsEpigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer.27358489
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsEpigenome-wide DNA methylation profiling was performed in surgically resected primary tumor tissues from a population-based (n = 430) and a replication (n = 80) cohort of prostate cancer patients followed prospectively for at least 5 years.27358489
Prostatic NeoplasmsEpigenetic AlterationsWe hypothesized that epigenetic alterations could distinguish prostate tumors with life-threatening potential.27358489
Prostate Cancer Pathway, Aggressive behaviorEpigenetic AlterationsThese novel epigenetic biomarkers warrant further investigation as they may improve prognostic classification of patients with clinically localized prostate cancer and provide new insights on tumor aggressiveness.27358489
Metastasis, Primary malignant neoplasmEpigenetic AlterationsFunctional investigations showed that MEF2D promoted cancer cell invasion and EMT and that it was essential for certain microenvironment signals to induce EMT and metastasis in vivo Mechanistically, MEF2D directly regulated transcription of the EMT driver gene ZEB1 and facilitated histone acetylation at the ZEB1 promoter.27364559
Secondary malignant neoplasm of liver, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsGenome-wide microRNA Expression Profiling in Primary Tumors and Matched Liver Metastasis of Patients with Colorectal Cancer.27365381
Primary Neoplasm, Secondary malignant neoplasm of liverEpigenetic AlterationsFirstly, expression profiling of 752 miRNAs in 20 primary tumors and their corresponding liver metastases was performed.27365381
Secondary malignant neoplasm of liver, Primary NeoplasmEpigenetic AlterationsIn total, 33 miRNAs were found to be significantly deregulated in liver metastases compared to their primary tumors.27365381
Secondary malignant neoplasm of liverEpigenetic AlterationsFifteen miRNAs were chosen for subsequent validation, which confirmed significantly reduced expression of miR-143, miR 10b, and miR-28-5p, and increased expression of miR 122, miR-122*, and miR 885-5p in the tissue of liver metastases.27365381
Clinical CoordinatorEpigenetic AlterationsThese results indicate that miRNAs could serve as new therapeutic targets in patients with metastatic CRC.27365381
NCI CTEP SDC Oligodendroglial Tumors Sub-Category TerminologyEpigenetic AlterationsThe influence of DNA methylation in oligodendroglial tumors is not fully understood.27367901
Neurotoxicity Syndromes, Antilymphocyte SerumEpigenetic AlterationsEpigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients.27368295
Neurotoxicity Syndromes, Antilymphocyte SerumEpigenetic AlterationsWe hypothesize that higher macrophage abundance and increased neurotoxic cytokines have a fundamental role in the phenotype and treatment of certain individuals with ALS.-Lam, L., Chin, L., Halder, R. C., Sagong, B., Famenini, S., Sayre, J., Montoya, D., Rubbi L., Pellegrini, M., Fiala, M. Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients.27368295
Cessation of life, Glioblastoma Multiforme PathwayEpigenetic AlterationsExpression of programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) across glioma grades is undocumented, and their interactions with commonly expressed genetic and epigenetic alterations are undefined but nonetheless highly relevant to combinatorial treatments.27370400
Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsMicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression.27371108
NeoplasmsEpigenetic AlterationsMicroRNA-506 (miR-506) has been reported to function in several tumors as a tumor suppressor gene or oncogene.27371108
NeoplasmsEpigenetic AlterationsOur results suggest that miR-506 either plays a role as an oncogene in the tumorigenesis and a tumor suppressor in the progression or serves as a house-keeping, tumor-suppressing miRNA, whose expression can be activated by oncogenic signals in early development to hinder the progression of PDAC.27371108
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMiRNA-200a expression is inverse correlation with hepatocyte growth factor expression in stromal fibroblasts and its high expression predicts a good prognosis in patients with non-small cell lung cancer.27374174
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHigh miRNA-200a and low HGF expression in stromal fibroblasts may predict a good prognosis in patients with NSCLC.27374174
Esophageal carcinomaEpigenetic AlterationsHowever, the epigenetic changes and mechanisms of NKD2 in human esophageal cancer remain unclear.27374455
Malignant Neoplasms, Vascular DiseasesEpigenetic AlterationsPolymorphisms in microRNA (miR) genes are thought to be associated with various cancers and vascular diseases.27379568
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsMicroRNA-205-5p is upregulated in myelodysplastic syndromes and induces cell proliferation via PTEN suppression.27379838
Pancreatic carcinoma, Autoimmune PancreatitisEpigenetic AlterationsSpecific MAPK-Associated MicroRNAs in Serum Differentiate Pancreatic Cancer from Autoimmune Pancreatitis.27380024
PancreasEpigenetic AlterationsRecently it has been reported that these miRNAs could be used as biomarkers in serum samples for accurate diagnosis of pancreatic lesions.27380024
Pancreatic Intraductal Papillary Mucinous Neoplasm, Acute intermittent porphyriaEpigenetic AlterationsPatients with PDAC or IPMN showed significantly higher amounts of serum MAPK-associated miRNAs than those with AIP (p<0.009 for miR-7, p<0.002 for miR-34a, p<0.001 for miR-181d, p<0.002 for miR-193b).27380024
Pancreatic Intraductal Papillary Mucinous Neoplasm, Acute intermittent porphyriaEpigenetic AlterationsSerum MAPK-associated miRNAs could be novel noninvasive biomarkers for differentiation between PDAC or IPMN and AIP.27380024
Breast CarcinomaEpigenetic AlterationsGenetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.27380242
Breast CarcinomaEpigenetic AlterationsWhile germline genetic variations may disrupt some of these interactions between miRNAs and their targets, studies assessing the relationship between genetic variations in the miRNA network and breast cancer risk are still limited, particularly among women of African ancestry.27380242
Breast CarcinomaEpigenetic AlterationsFor overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have significant associations in both discovery and validation phases.27380242
Breast CarcinomaEpigenetic AlterationsSeveral variants in miRNA and miRNA biogenesis pathway genes were associated with breast cancer risk.27380242
Stomach CarcinomaEpigenetic AlterationsSerum microRNA expression profile as a diagnostic panel for gastric cancer.27380811
Colorectal Cancer PathwayEpigenetic AlterationsPreviously, we identified six miRNAs that are differentially expressed in colorectal cancer compared with healthy controls.27380811
Stomach CarcinomaEpigenetic AlterationsThe signature of these five miRNAs is a novel and noninvasive biomarker for gastric cancer, and could facilitate and simplify its diagnosis.27380811
Pulmonary HypertensionEpigenetic AlterationsUpregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via Targeting CCNL2.27381447
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsDuring the last decades it has been established that breast cancer arises through the accumulation of genetic and epigenetic alterations in different cancer related genes.27383829
bone destructionEpigenetic AlterationsThe expression of these two miRNAs may indicate severity of bone destruction.27384730
Adenocarcinoma of prostateEpigenetic AlterationsAdenocarcinomas of the prostate arise as multifocal heterogeneous lesions as the likely result of genetic and epigenetic alterations and deranged cell-cell communication.27384993
Intervertebral Disc Degeneration, Primary malignant neoplasmEpigenetic AlterationsAccumulating evidence indicates that miRNAs, a class of small non-coding RNAs, are implicated in the pathogenesis of various diseases such as cancer and intervertebral disc degeneration.27385596
Intervertebral Disc DegenerationEpigenetic AlterationsmicroRNA-34a inhibition may be a novel molecular target for intervertebral disc degeneration treatment through the prevention of nucleus pulposus extracellular matrix degradation.27385596
Von Hippel-Lindau Syndrome, NeoplasmsEpigenetic AlterationsDespite the identification of germline and/or epigenetic mutations of Von Hippel Lindau (VHL) gene as an important pathogenic mechanism of HB, little is known about the molecular signaling involved in this highly vascularized tumor.27388534
Cerebral IschemiaEpigenetic AlterationsLentivirus-Mediated Overexpression of MicroRNA-210 Improves Long-Term Outcomes after Focal Cerebral Ischemia in Mice.27390218
Brain InjuriesEpigenetic AlterationsMicroRNAs play an important role in the pathogenesis of ischemic brain injury and in the repair process during postischemic condition.27390218
Cerebrovascular accidentEpigenetic AlterationsWe found that 24 MicroRNAs were differently expressed in stroke patients compared to the control (P < 0.05).27390218
Malignant neoplasm of urinary bladderEpigenetic AlterationsmiR-130b, an onco-miRNA in bladder cancer, is directly regulated by NF-kB and sustains NF-kB activation by decreasing Cylindromatosis expression.27391066
Acute lymphocytic leukemiaEpigenetic AlterationsWe further observed that CK2 inhibitor induces increased H3K9me3 histone modifications in the CRLF2 promoter in ALL cell lines and primary cells.27391346
SERPINB3 wt AlleleEpigenetic AlterationsIn addition, we validated seven microRNAs whose expression was shown to be higher in OLD tissue in comparison with the control and OSCC tissues.27391377
Secondary malignant neoplasm of liver, Colorectal Cancer PathwayEpigenetic AlterationsLong non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer.27391432
Idiopathic Pulmonary FibrosisEpigenetic AlterationsOur findings suggest that attenuated expression of miR-185 and miR-186 may be responsible for collagen V overexpression during idiopathic pulmonary fibrosis, and these miRNAs may serve as pathogenesis-related biomarkers and treatment targets.27392970
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDecreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers.27393180
Breast Carcinoma, NeoplasmsEpigenetic AlterationsWe have generated mRNA, miRNA, and DNA copy-number profiles from a total of 59 in situ lesions and 85 invasive tumors in order to comprehensively identify those genes, signaling pathways, processes, and cell types that are involved in breast cancer progression.27396337
Breast Carcinoma, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsLoss of microRNA-145 expression is involved in the development and prognosis of breast cancer complicated by type 2 diabetes mellitus.27396353
hearing impairmentEpigenetic AlterationsThus, other modification factors, such as environmental factor, aminoglycosides or epigenetic modification may have contributed to the high penetrance of hearing loss in this family.27397648
Malignant Neoplasms, Metastasis, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) in tumors participate in multiple processes of malignancy development, including cell differentiation, proliferation, invasion, and metastasis.27399918
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe effect of celecoxib on DNA methylation of CDH13, TFPI2, and FSTL1 in squamous cell carcinoma of the esophagus in vivo.27400374
Squamous cell carcinoma of esophagusEpigenetic AlterationsIn ESCC, in-vivo treatment with celecoxib is associated with a reduction in DNA methylation and increase in messenger RNA expression of tumor-suppressor genes, and increases in apoptosis.27400374
Chordoma, Primary malignant neoplasmEpigenetic AlterationsThese 294 differentially expressed genes and non-coding RNA transcripts provide here a set to specifically define skull base chordomas and to identify novel and potentially important targets for diagnosis, prognosis, and therapy of this cancer.27401718
cervical cancer, Cervical Intraepithelial NeoplasiaEpigenetic AlterationsTo conduct a comprehensive mapping of the genomic DNA methylation in CDKN2A, which codes for the p16(INK4A) and p14(ARF) proteins, and 14 of the most promising DNA methylation marker candidates previously reported to be associated with progression of low-grade cervical intraepithelial neoplasia (CIN1) to cervical cancer.27401842
cervical cancerEpigenetic AlterationsWe analyzed DNA methylation in 68 HIV-seropositive and negative women with incident CIN1, CIN2, CIN3 and invasive cervical cancer, assaying 120 CpG dinucleotide sites spanning APC, CDH1, CDH13, CDKN2A, CDKN2B, DAPK1, FHIT, GSTP1, HIC1, MGMT, MLH1, RARB, RASSF1, TERT and TIMP3 using the Illumina Infinium array.27401842
Primary malignant neoplasmEpigenetic AlterationsIn our discovery sample set, we identified dose dependent differences in DNA methylation with grade of disease in CDKN2A, APC, MGMT, MLH1 and HIC1, whereas single CpG locus differences between CIN2/3 and cancer groups were seen for CDH13, DAPK1 and TERT.27401842
Cervix Diseases, malignant diseaseEpigenetic AlterationsOur data suggests a novel link between early cervical disease progression and DNA methylation in a region downstream of the CDKN2A transcription start site that may lead to increased p16(INK4A)/p14(ARF) expression prior to development of malignant disease.27401842
Cervical Intraepithelial NeoplasiaEpigenetic AlterationsNovel epigenetic changes in CDKN2A are associated with progression of cervical intraepithelial neoplasia.27401842
Carcinoma, Ovarian EpithelialEpigenetic AlterationsDevelopment and validation of a microRNA-based signature (MiROvaR) to predict early relapse or progression of epithelial ovarian cancer: a cohort study.27402147
Carcinoma, Ovarian EpithelialEpigenetic AlterationsWe aimed to develop a microRNA (miRNA)-based molecular classifier that can predict risk of progression or relapse in patients with epithelial ovarian cancer.27402147
ovarian neoplasmEpigenetic AlterationsWe identified 35 miRNAs that predicted risk of progression or relapse and used them to create a prognostic model, the 35-miRNA-based predictor of Risk of Ovarian Cancer Relapse or progression (MiROvaR).27402147
Malignant neoplasm of larynx, Liquid ChromatographyEpigenetic AlterationsMicroRNAs (miRNAs) play critical roles in the progression of laryngeal cancer (LC).27403438
Initiation, Primary malignant neoplasmEpigenetic AlterationsThe small noncoding RNAs (miRNAs) considered as master regulator of gene expression play a key role in cancer initiation, progression and drug resistance and have emerged as attractive molecular biomarkers for diagnosis, prognosis and treatment targets in cancer.27404381
Breast CarcinomaEpigenetic AlterationsIdentification of Specific miRNA Signature in Paired Sera and Tissue Samples of Indian Women with Triple Negative Breast Cancer.27404381
Breast Carcinoma, NeoplasmsEpigenetic AlterationsWe report for the first time an extremely high prevalence (73.9%) of TNBC in premenopausal women below 35 years of age and a significant altered expression of a panel of three specific oncogenic miRNAs- miR-21, miR-221, miR-210, and three tumor suppressor miRNAs- miR-195, miR-145 and Let-7a in both tissues and corresponding sera of TNBC patients when compared with triple positive breast cancer (TPBC) patients.27404381
Chronic Obstructive Airway DiseaseEpigenetic AlterationsMicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease.27409149
Chronic Obstructive Airway DiseaseEpigenetic AlterationsWe performed miRNA and mRNA profiling using high throughput stem-loop reverse-transcriptase quantitative polymerase chain reaction and mRNA microarray, respectively, on lung tissue of 30 patients (screening cohort) encompassing 8 never-smokers, 10 smokers without airflow limitation, and 12 smokers with COPD.27409149
Chronic Obstructive Airway DiseaseEpigenetic AlterationsDifferential expression of miRNA-218-5p (miR-218-5p) was validated by reverse-transcriptase quantitative polymerase chain reaction in an independent cohort of 71 patients, an in vivo murine model of COPD, and primary human bronchial epithelial cells.27409149
Chronic Obstructive Airway DiseaseEpigenetic AlterationsTo identify dysregulated miRNAs in lung tissue of patients with chronic obstructive pulmonary disease (COPD).27409149
Breast CarcinomaEpigenetic AlterationsIdentification of a circulating microRNA signature to distinguish recurrence in breast cancer patients.27409424
Breast CarcinomaEpigenetic AlterationsWe conducted a microRNA profiling experiment in serum samples from 48 breast cancer patients using Exiqon miRCURY microRNA RT-PCR panels.27409424
Breast CarcinomaEpigenetic AlterationsUsing penalized logistic regression, we built a 7-miRNA signature for breast cancer recurrence, which had an excellent discriminating capacity (concordance index=0.914).27409424
Breast CarcinomaEpigenetic AlterationsWe also found the 7-miRNA signature were reliably measured across different runs of PCR experiments (intra-class correlation coefficient=0.780) and the signature was significantly higher in breast cancer patients with recurrence than healthy controls (p=1.1x10-5).27409424
Breast CarcinomaEpigenetic AlterationsSignificantly differentiated miRNAs for recurrence in the discovery profiling were further validated in an independent set of sera from 20 patients with breast cancer recurrences and 22 patients without recurrences.27409424
Breast CarcinomaEpigenetic AlterationsWe identified seven miRNAs that were differentially expressed between breast cancer patients with and without recurrences, including four miRNAs upregulated (miR-21-5p, miR-375, miR-205-5p, and miR-194-5p) and three miRNAs downregulated (miR-382-5p, miR-376c-3p, and miR-411-5p) for recurrent patients.27409424
Breast CarcinomaEpigenetic AlterationsIn conclusion, circulating miRNAs are promising biomarkers and the signature may be developed into a minimally invasive multi-marker blood test for continuously monitoring the recurrence of breast cancer.27409424
Rheumatoid ArthritisEpigenetic AlterationsMicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis.27411480
Keratoconus, Glaucoma, CTCAEEpigenetic AlterationsWe also identified uniquely expressed miRNAs, of which five share 18 highly validated gene targets, and created a profile of miRNAs known to target genes associated with keratoconus and glaucoma.27415791
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsObjective MicroRNA-154 (miR-154) was previously reported to be downregulated in several types of human cancers and may act as a tumour suppressor.27417886
Malignant Neoplasms, Ovarian Serous AdenocarcinomaEpigenetic AlterationsMultiple investigations reported miRNAs aberrantly expressed in several cancers, including high-grade serous ovarian carcinoma (HGS-OvCa).27419385
Stomach CarcinomaEpigenetic AlterationsCirculating microRNA-196a/b are novel biomarkers associated with metastatic gastric cancer.27420607
Stomach CarcinomaEpigenetic AlterationsHowever, the clinical significance of these microRNAs in gastric cancer (GC) remains to be clarified.27420607
Prostate Cancer PathwayEpigenetic AlterationsAs one epigenetic regulation mechanism, DNA methylation of the whole genome and specific gene(s) plays critical roles in pathogenesis, progression, diagnosis, and treatment of prostate cancer.27420993
Malignant Neoplasms, Prostate Cancer PathwayEpigenetic AlterationsDNA methylation level of the E-Cadherin gene could be an important predictive index for malignancy of prostate cancer.27420993
cervical cancerEpigenetic AlterationsA microRNA expression signature for clinical response in locally advanced cervical cancer.27423381
cervical cancerEpigenetic AlterationsThese seven validated miRNA signatures could be used as molecular biomarkers of chemo- and radio-resistance in locally advanced cervical cancer patients.27423381
Cardiac ArrestEpigenetic AlterationsCirculating microRNAs and sudden cardiac arrest outcomes.27423422
Cardiac Arrest, Ventricular FibrillationEpigenetic AlterationsMicroRNAs (miRNAs) have regulatory functions in organs critical in resuscitation from sudden cardiac arrest due to ventricular fibrillation (VF-SCA); therefore, circulating miRNAs may be markers of VF-SCA outcome.27423422
Primary malignant neoplasmEpigenetic AlterationsmicroRNAs (miRNAs) are small noncoding RNAs that have become potential biomarkers and molecular targets for cancer treatment.27427222
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsExpression of miRNA-21 and miRNA-221 in clear cell renal cell carcinoma (ccRCC) and their possible role in the development of ccRCC.27427222
NeoplasmsEpigenetic AlterationsmiRNA-21 and miRNA-221 expressions were significantly up-regulated in tumor specimens compared to normal tissue (P<0.05).27427222
NeoplasmsEpigenetic AlterationsExpression of oncogenic miRNA-21 and miRNA-221 in human ccRCC tumor tissue samples compared to adjacent nontumorous tissues might suggest that these miRNAs are involved in the development of ccRCC.27427222
FibromyalgiaEpigenetic AlterationsWe found 51 aberrantly expressed miRNAs in white blood cells of patients with FMS, of which miR-let-7d correlated with reduced small nerve fiber density in patients with FMS.27429177
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAberrant microRNA (miRNA) expression has been shown to have a role in CLL pathogenesis; however, a comparison of miRNA expression between CLL cells in the LN and the peripheral blood (PB) has previously not been reported.27431016
Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsIbrutinib downregulates a subset of miRNA leading to upregulation of tumor suppressors and inhibition of cell proliferation in chronic lymphocytic leukemia.27431016
NeoplasmsEpigenetic AlterationsThese findings demonstrate that ibrutinib downregulates the expression of a subset of miRNAs related to B-cell activation leading to increased expression of miRNA targets including tumor suppressors and a reduction in cell proliferation.27431016
Esophageal carcinomaEpigenetic AlterationsThe long noncoding RNA CASC9 regulates migration and invasion in esophageal cancer.27431358
Squamous cell carcinoma of esophagusEpigenetic AlterationsLong noncoding RNAs (lncRNAs) upregulated in ESCC tissues were detected by RNA sequencing.27431358
Breast CarcinomaEpigenetic AlterationsPrognostic value of microRNA-203a expression in breast cancer.27431784
Malignant NeoplasmsEpigenetic AlterationsThe single nucleotide polymorphism (SNP) rs6983267 and cancer-associated region long non-coding RNA (CARLo-5) are associated with various human cancers.27432114
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsDNA methylation profiling of heterogeneous head and neck squamous cell carcinoma (HNSCC) cohorts has been reported to predict patient outcome.27433284
Neoplasms, Trauma Symptom Checklist for Children QuestionnaireEpigenetic AlterationsWith genome-scale assessment of DNA methylation using HM450K in one of the largest OTSCC cohorts to date, we were unable to identify a hypermethylated group of tumours or a prognostic methylation signature.27433284
Trauma Symptom Checklist for Children QuestionnaireEpigenetic AlterationsThis suggests that either DNA methylation in isolation is not likely to be of prognostic value or larger cohorts are required to identify such a biomarker for OTSCC.27433284
Acute Myeloid Leukemia Arising from Previous Myelodysplastic SyndromeEpigenetic AlterationsEpigenetic landscape of the TERT promoter: a potential biomarker for high risk AML/MDS.27433923
Prostate Cancer PathwayEpigenetic AlterationsMicroRNA-21 in peripheral blood mononuclear cells as a novel biomarker in the diagnosis and prognosis of prostate cancer.27434290
NeoplasmsEpigenetic AlterationsExemplarily, gene-specific analyses of DNA methylation, mRNA and protein expression demonstrate lack of expression of the clinically important drug transporter OCT2 (encoded by SLC22A2) in cell lines due to hypermethylation compared to tumors or metastases.27435027
Refractory Cytopenia of ChildhoodEpigenetic AlterationsOur findings provide evidence that RCC cell lines are of limited benefit for prediction of drug effects due to epigenetic alterations.27435027
NeoplasmsEpigenetic AlterationsSimilar epigenetic landscape of ccRCC-metastases and tumors opens new avenue for future therapeutic strategies.27435027
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe prognostic value of a seven-microRNA classifier as a novel biomarker for the prediction and detection of recurrence in glioma patients.27438144
Glioblastoma MultiformeEpigenetic AlterationsWe hypothesized that the microRNA expression profile may serve as a biomarker for the prognosis and prediction of glioblastoma recurrence.27438144
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe seven-miRNA-based classifier should be useful in the stratification and individualized management of patients with glioma.27438144
Primary malignant neoplasm, Glioblastoma MultiformeEpigenetic AlterationsWe defined microRNAs that were associated with good and poor prognosis in 300 specimens of glioblastoma from the Cancer Genome Atlas.27438144
Malignant Neoplasms, Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsAltered expression of microRNAs (miRNAs) has been shown in many types of malignancies including the head and neck squamous cell carcinoma (HNSCC).27440205
HypoxiaEpigenetic AlterationsInvestigation as part of a miRNA hypoxia signature may reveal the full potential of miR-210.27441495
allergic inflammationEpigenetic AlterationsSeveral changes in miRNA expression have been found as a result of the buildup phase of wasp VIT, with lower expression of some miRNAs involved in allergic inflammation and higher expression of those possibly involved in tolerance induction.27441833
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe decrease in miRNA-29b expression was statistically significant and differentiated NSCLC histopathological subtypes.27447710
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are involved in tumorigenesis and function as oncogenes or tumor suppressor genes.27447710
Metastasis, NeoplasmsEpigenetic AlterationsAmong other genes, miRNAs regulate matrix metalloproteinases (MMPs), the proteolytic enzymes playing a significant role in the degradation of extracellular matrix, enhancing tumor invasion and metastasis.27447710
CarcinogenesisEpigenetic AlterationsThe results of our pilot study indicated the diagnostic potential of miR-29b and MMP-2, an inverse association between miR-26a and MMP-2, and proved the role of MMP-2 and the studied miRNAs in lung carcinogenesis.27447710
cervical cancerEpigenetic AlterationsSeven protective miRNA signatures for prognosis of cervical cancer.27447860
cervical cancerEpigenetic AlterationsTCGA data of patients with cervical cancer were used to build univariate Coxs model with single clinical parameter or miRNA expression level.27447860
PRB1 geneEpigenetic AlterationsContrarily, DNA methylation genes (DNMT3A, IDH1, IDH2 and TET2) were mutated most often in PV (0*5) and less frequently in ET (0*23) and PMF (0*20), but without reaching statistical significance.27447873
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) are emerging as crucial regulators of cancer.27449043
Myeloproliferative diseaseEpigenetic AlterationsRapid Molecular Profiling of Myeloproliferative Neoplasms Using Targeted Exon Resequencing of 86 Genes Involved in JAK-STAT Signaling and Epigenetic Regulation.27449473
Clinical CoordinatorEpigenetic AlterationsThe relationship between the DNA methylation status of the CpG islands of multiple genes in blood leukocytes in CRC susceptibility and prognosis, as well as possible interactions with dietary factors on CRC risk are unclear.27453436
Pancreatic carcinomaEpigenetic AlterationsMicroRNA Expression in a Readily Accessible Common Hepatic Artery Lymph Node Predicts Time to Pancreatic Cancer Recurrence Postresection.27456015
palladiumEpigenetic AlterationsStation 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR.27456015
Neoplasm of ampulla of VaterEpigenetic AlterationsWe conclude that elevated miRNA-10b levels in station 8 lymph nodes could be utilized to assess risk for early disease progression in patients with periampullary tumors.27456015
Breast CarcinomaEpigenetic AlterationsMicroRNA-497 downregulation contributes to cell proliferation, migration, and invasion of estrogen receptor alpha negative breast cancer by targeting estrogen-related receptor alpha.27456360
Primary malignant neoplasmEpigenetic AlterationsKnockdown of Long Noncoding RNA PCAT6 Inhibits Proliferation and Invasion in Lung Cancer Cells.27458097
Prostate Cancer Pathway, ProstateEpigenetic AlterationsAs a newly identified oncogenic long noncoding RNA (lncRNA), prostate cancer-associated transcript 6 (PCAT6) promoted cellular proliferation and colony formation of prostate cancer.27458097
Leukemia, Myelocytic, AcuteEpigenetic AlterationsImmunohistochemical loss of 5-hydroxymethylcytosine expression in acute myeloid leukaemia: relationship to somatic gene mutations affecting epigenetic pathways.27458708
Myeloid neoplasm, Leukemia, Myelocytic, AcuteEpigenetic AlterationsGenes affecting epigenetic pathways are frequently mutated in myeloid malignancies, including acute myeloid leukaemia (AML).27458708
Stomach CarcinomaEpigenetic AlterationsEpigenetic suppression of the immunoregulator MZB1 is associated with the malignant phenotype of gastric cancer.27459504
Alzheimers DiseaseEpigenetic AlterationsNeurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimers disease.27459923
AngularEpigenetic Alterations5mC and 5hmC were present in a high proportion of neurofibrillary tangles, suggesting no loss of DNA methylation marks in tangle bearing neurons.27459923
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsThere is increasing evidence that epigenetic alterations may play a role in Alzheimers disease (AD); yet, there is little information regarding epigenetic modifications in specific cell types.27459923
Admitting diagnosisEpigenetic AlterationsWe provide evidence that epigenetic dysregulation may be occurring in astrocytes and NF-positive pyramidal neurons in AD.27459923
Breast CarcinomaEpigenetic AlterationsDNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac.27461117
Malignant NeoplasmsEpigenetic AlterationsIn addition, it is reported that CLDN6 expression is regulated by DNA methylation in various human cancers and cell lines.27461117
Breast CarcinomaEpigenetic AlterationsHere we show the mechanism by which DNA methylation regulates CLDN6 expression in human breast cancer cell line MCF-7.27461117
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDown-expression of circulating micro ribonucleic acid (miRNA)-148/152 family in plasma samples of non-small cell lung cancer patients.27461630
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe levels of miRNA-148/152 family were detected by TaqMan quantitative polymerase chain reaction (qPCR) assay in plasma of 20 NSCLC patients and 10 healthy individuals.27461630
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe circulating level of all three members of miRNA-148/152 family were significantly lower in plasma samples of NSCLC patients compared with those of healthy controls (P = 0.007, P = 0.003, and P = 0.000, respectively).27461630
Malignant NeoplasmsEpigenetic AlterationsCirculating extracellular micro ribonucleic acids (miRNAs) are considered as potential biomarkers for malignancy detection and diagnosis.27461630
Occult Lung Non-Small Cell CarcinomaEpigenetic AlterationsIncreased expression of microRNA-301a in nonsmall-cell lung cancer and its clinical significance.27461635
Primary malignant neoplasmEpigenetic AlterationsRecently, accumulating evidence indicates that dysregulation of microRNAs is associated with the initiation and progression of cancer.27461635
Liver carcinomaEpigenetic AlterationsCirculating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function.27462777
Hollings Cancer CenterEpigenetic Alterations(1) Four oncogenic miRNAs (miR-151, 155, 191 and 224) with high expression in HCC tissues were selected as candidates.27462777
Non-Small Cell Lung CarcinomaEpigenetic AlterationsOur findings provide information on the epigenetic signature of the two major sensitive mutations among NSCLC and add to the understanding of mechanisms underlying the different outcomes.27463019
Non-Small Cell Lung CarcinomaEpigenetic AlterationsPlasma MiRNA alterations between NSCLC patients harboring Del19 and L858R EGFR mutations.27463019
NeoplasmsEpigenetic AlterationsLevels of DNA Methylation Vary at CpG Sites across the BRCA1 Promoter, and Differ According to Triple Negative and "BRCA-Like" Status, in Both Blood and Tumour DNA.27463681
NeoplasmsEpigenetic AlterationsThe levels of tumour DNA methylation were significantly higher in triple negative tumours, and in tumours with high BRCA-like histopathological scores (10 of 11 CpG sites; p<0.01 and p<0.007 respectively).27463681
OsteoporosisEpigenetic AlterationsIn conclusion, the presence of heavy metals into bone shed new light on the comprehension of the pathogenesis of osteoporosis since these elements could play a non redundant role in the development of osteoporosis at cellular/molecular and epigenetic level.27464007
Cardiovascular DiseasesEpigenetic AlterationsMore and more evidence indicate that miRNA plays an important role in the pathophysiology of many diseases, especially the occurrence and development of cardiovascular diseases.27464494
Pituitary NeoplasmsEpigenetic AlterationsMicroRNA-106b promotes pituitary tumor cell proliferation and invasion through PI3K/AKT signaling pathway by targeting PTEN.27465551
Malignant neoplasm of urinary bladder, NeoplasmsEpigenetic AlterationsAlterations of global histone modification levels have been identified in various tumor entities, including bladder cancer (BCA).27466500
Malignant neoplasm of urinary bladderEpigenetic AlterationsEvaluation of Global Histone Acetylation Levels in Bladder Cancer Patients.27466500
Malignant neoplasm of urinary bladder, Primary malignant neoplasmEpigenetic AlterationsGlobal histone acetylation levels undergo quantitative alterations during bladder cancer progression and could be helpful to identify patients at risk for early cancer recurrence.27466500
Unipolar DepressionEpigenetic AlterationsThe microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression.27468165
Mental disordersEpigenetic AlterationsThese findings support a mechanistic role for miRNAs in the regulation of stress-responsive genes disrupted in psychiatric illness.27468165
Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsUpregulation of the long non-coding RNA BANCR correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma.27470379
NeoplasmsEpigenetic AlterationsRecent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the tumor progression and poor prognosis.27470379
Colorectal NeoplasmsEpigenetic AlterationsA Highly Predictive Model for Diagnosis of Colorectal Neoplasms Using Plasma MicroRNA: Improving Specificity and Sensitivity.27471839
Colorectal NeoplasmsEpigenetic AlterationsTo develop a plasma-based microRNA (miRNA) diagnostic assay specific for colorectal neoplasms, building upon our prior work.27471839
Colorectal Neoplasms, NeoplasmsEpigenetic AlterationsOur plasma miRNA assay and prediction model differentiate colorectal neoplasia from patients with other neoplasms and from controls with higher sensitivity and specificity compared with current clinical standards.27471839
Clinical Coordinator, Breast Carcinoma, Pancreatic carcinoma, Carcinoma of lungEpigenetic AlterationsPlasma was screened for 380 miRNAs using microfluidic array technology from a "Training" cohort of 60 patients, (10 each) control, CRC, CAA, breast cancer, pancreatic cancer, and lung cancer.27471839
Colorectal NeoplasmsEpigenetic AlterationsWe identified uniquely dysregulated miRNAs specific for colorectal neoplasia (P < 0.05, false discovery rate: 5%, adjusted a = 0.0038).27471839
Mycosis FungoidesEpigenetic AlterationsGenomic imbalances and microRNA transcriptional profiles in patients with mycosis fungoides.27473081
Hollings Cancer CenterEpigenetic AlterationsBiological and cDNA/miRNA microarray data were compared among CD44-positive/-negative HCC cells and normal hepatic cells.27473646
Portal vein structure, Hollings Cancer CenterEpigenetic AlterationsOf the six miRNAs, miR-137 was closely associated with overall and cancer-specific survivals, as well as with invasion of hepatic vein, hepatic artery, portal vein and bile duct, and alpha-foetoprotein in additional 110 HCC patients.27473646
Hematologic NeoplasmsEpigenetic AlterationsEpigenetic alteration may play a role in age-associated dysfunction of stem cells and predispose to the development of hematological cancers.27475703
Malignant Peripheral Nerve Sheath Tumor, NeoplasmsEpigenetic AlterationsAlthough loss of the NF1 gene predisposes to MPNST induction, relatively long tumor latency in NF1 patients suggests that additional genetic or epigenetic abnormalities are needed for the development of these nerve sheath malignancies.27477693
Huntington DiseaseEpigenetic AlterationsHuntingtons disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels.27479945
Hodgkin DiseaseEpigenetic AlterationsWe sought to inquire if HD is associated with an accelerated epigenetic age.27479945
Hodgkin DiseaseEpigenetic AlterationsOverall, brain regions from HD cases exhibit a significant epigenetic age acceleration effect (p=0.0012).27479945
Hodgkin DiseaseEpigenetic AlterationsAfter excluding controls, we observe a negative correlation (r=-0.41, p=5.5x10-8) between HD gene CAG repeat length and the epigenetic age of HD brain samples.27479945
Hodgkin DiseaseEpigenetic AlterationsIn conclusion, HD is associated with an accelerated epigenetic age of specific brain regions and more broadly with substantial changes in brain methylation levels.27479945
NeoplasmsEpigenetic AlterationsMolecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients.27484791
Adenocarcinoma of lung (disorder)Epigenetic AlterationsA prognostic predictor panel with DNA methylation biomarkers for early-stage lung adenocarcinoma in Asian and Caucasian populations.27484806
NeoplasmsEpigenetic AlterationsAdditionally, miRNA expression was compared between CC and normal colon mucosa samples and between the mismatch repair (MMR) competent and deficient tumours.27485175
NeoplasmsEpigenetic AlterationsWe assessed by qRT-PCR expression of 754 microRNAs (miRNAs) in tumour samples from 85 stage pT2-3N0 CC patients treated with surgery alone.27485175
NeoplasmsEpigenetic AlterationsThe expression of several novel miRNAs were found to be tumour specific, e.g.27485175
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-610 is downregulated in glioma cells, and inhibits proliferation and motility by directly targeting MDM2.27485527
Stomach Carcinoma, Liver carcinomaEpigenetic AlterationsThe expression of microRNA (miR)-610 has previously been reported to be downregulated in gastric cancer and hepatocellular carcinoma.27485527
Malignant tumor of colonEpigenetic AlterationsSerum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer.27485599
Malignant tumor of colonEpigenetic AlterationsA diagnostic four-microRNA signature consisting of miR-23a-3p, miR-27a-3p, miR-142-5p and miR-376c-3p was established (AUC = 0.917), distinguishing colon cancer patients from healthy donors with sensitivity of 89% and specificity of 81% (AUC = 0.922).27485599
Malignant tumor of colonEpigenetic AlterationsFifty-four microRNAs were found to be significantly deregulated in serum of colon cancer patients compared to healthy donors (P < 0.01).27485599
Malignant tumor of colonEpigenetic AlterationsThis panel of microRNAs exhibited high diagnostic performance also when analyzed separately in colon cancer patients in early stages of the disease (T1-4N0M0; AUC = 0.877).27485599
Malignant tumor of colonEpigenetic AlterationsIn summary, highly sensitive signatures of circulating microRNAs enabling non-invasive early detection and prognosis prediction of colon cancer were identified.27485599
Carcinoma of lung, Liquid ChromatographyEpigenetic AlterationsAnalysis of epigenetic alterations such as methylation of circulating-free DNA (cf-DNA) expression significantly broadened perspectives of lung cancer (LC) screening.27485611
NeoplasmsEpigenetic AlterationsDNA methylation, as the most frequent mechanism for gene silencing, has been widely investigated in regards to the development of tumors.27485791
Malignant neoplasm of ovaryEpigenetic AlterationsThus, FBXW7 expression was downregulated in ovarian cancers, and was associated with p53 mutations and the DNA methylation status of the 5-upstream regions of FBXW7.27486687
Carcinoma of lung, Idiopathic Pulmonary FibrosisEpigenetic AlterationsRegulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis.27488440
Atrial FibrillationEpigenetic AlterationsOxidized Low-density Lipoprotein (ox-LDL) Cholesterol Induces the Expression of miRNA-223 and L-type Calcium Channel Protein in Atrial Fibrillation.27488468
Rheumatic Heart DiseaseEpigenetic AlterationsOur results implicate a new molecular mechanism for AF in which miRNA-223 can be used as an biomarker of AF rheumatic heart disease.27488468
Non-Small Cell Lung Carcinoma, Neoplasm MetastasisEpigenetic AlterationsCollectively, our data suggest that histone modifications play a major role leading to epigenetic silencing of GAS5-AS1 in NSCLC and subsequently promote tumor metastasis via upregulation of several key EMT markers.27489122
Non-Small Cell Lung Carcinoma, Neoplasm MetastasisEpigenetic AlterationsDownregulation of the long noncoding RNA GAS5-AS1 contributes to tumor metastasis in non-small cell lung cancer.27489122
Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNA (lncRNA) plays pivotal roles in cancer development.27489122
Nasopharyngeal carcinomaEpigenetic AlterationsDistinctive microRNA expression in early stage nasopharyngeal carcinoma patients.27489139
Prostate Cancer PathwayEpigenetic AlterationsThe utility of urine-circulating miRNAs for detection of prostate cancer.27490805
Prostatic Hyperplasia, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe abundance of selected miRNAs was analysed in urine specimens from two independent cohorts of patients with PCa (N=215 overall), benign prostatic hyperplasia (BPH; N=23), and asymptomatic controls (ASC; N=62) by means of quantitative reverse transcription PCR.27490805
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsOver 100 miRNAs were found deregulated in PCa as compared with non-cancerous prostate tissue.27490805
Squamous cell carcinomaEpigenetic AlterationsWT1, MSH6, GATA5 and PAX5 as epigenetic oral squamous cell carcinoma biomarkers - a short report.27491556
SERPINB3 wt AlleleEpigenetic AlterationsTo the best of our knowledge, this is the first study that highlights this specific set of genes as epigenetic diagnostic and prognostic biomarkers in OSCC.27491556
Ulcerative Colitis, InflammationEpigenetic AlterationsA long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation.27492330
Clinical CoordinatorEpigenetic AlterationsDNA methylation changes have been regarded as promising biomarkers for CRC diagnosis.27493446
Clinical CoordinatorEpigenetic AlterationsHere, we map DNA methylation profiling on CRC in six CRCs and paired normal samples using a 450 K bead array.27493446
Clinical CoordinatorEpigenetic AlterationsOur data suggests that aberrant DNA methylation of ADD2 and AKR1B1 could be potential screening markers of CRC.27493446
Stomach CarcinomaEpigenetic AlterationsThus, our results demonstrate that expression of ADAMTS8 mRNA is significantly decreased and DNA methylation is frequent in gastric cancer.27493958
Liver carcinomaEpigenetic AlterationsMiRNA-22 inhibits oncogene galectin-1 in hepatocellular carcinoma.27494859
Hollings Cancer CenterEpigenetic AlterationsOn the other hand, galectin-1 and miRNA-22 (miR-22) are dysregulated in HCC and serve as prognostic indicators for patients.27494859
Primary NeoplasmEpigenetic AlterationsTwelve patients with lymph node metastases were included for comparison, and the sum value of the DDCt of 5 miRNAs between primary tumors and lymph node metastases was <9.27495091
GliomaEpigenetic AlterationsMiRNA expression profiling in human gliomas: upregulated miR-363 increases cell survival and proliferation.27495233
Astrocytoma, Glioblastoma Multiforme, Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsMultiplex real-time PCR was used to profile miRNA expression in a set of World Health Organization (WHO) grade I (pilocytic astrocytoma), II (diffuse fibrillary astrocytoma), and IV (glioblastoma multiforme) astrocytic tumors and primary glioma cell cultures.27495233
Glioblastoma Multiforme PathwayEpigenetic AlterationsmiRNA microarray showed that a set of miRNAs was consistently upregulated in all glioma samples.27495233
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe role of microRNAs (miRNAs) in glioma biology is increasingly recognized.27495233
Septicemia, Diabetes MellitusEpigenetic AlterationsPatients with and without diabetes mellitus, who had sepsis demonstrated similar transcriptional alterations, comprising 74 % of the expressed gene content and involving over-expression of genes associated with pro-inflammatory, anti-inflammatory, Toll-like receptor and metabolic signaling pathways and under-expression of genes associated with T cell signaling pathways.27495247
Primary malignant neoplasm, Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.27495872
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHerein, we demonstrated that miR-187-5p is a tumor-suppressor miRNA in NSCLC progression.27495872
Hypoxia, NeoplasmsEpigenetic AlterationsLong intergenic noncoding RNA-p21 (lincRNA-p21) is a long noncoding RNA transcriptionally activated by tumor protein p53 (TP53) and hypoxia inducible factor 1 alpha subunit (HIF1A).27496652
Coronary Artery Disease, Angina PectorisEpigenetic AlterationsPlasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris.27497911
Acute myocardial infarctionEpigenetic AlterationsAs an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as a potential biomarker of acute myocardial infarction.27497911
Rheumatoid ArthritisEpigenetic AlterationsMicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis.27498552
Rheumatoid Arthritis, Right armEpigenetic AlterationsFibroblast-like synoviocytes (FLS) with aberrant expression of microRNA (miRNA) are critical pathogenic regulators in rheumatoid arthritis (RA).27498552
ArthritisEpigenetic AlterationsPrevious studies have found that overexpression or silencing of miRNA can contribute to the development of miRNA-based therapeutics in arthritis models.27498552
CarcinogenesisEpigenetic AlterationsTaken together, these observations demonstrates a novel epigenetic feedback loop between miR-200c and DNMT3a in the carcinogenesis and progression of GC.27498672
Malignant NeoplasmsEpigenetic AlterationsAberrant methylation of miRNAs is commonly observed in cancers.27498672
NeoplasmsEpigenetic AlterationsHigh-throughput sequencing was used to detect the genetic and microRNA (miRNA) levels of tumor tissues.27498785
Metastasis, Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-140 represses glioma growth and metastasis by directly targeting ADAM9.27498787
Malignant Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNAs (miRNAs) have been demonstrated to play important roles in the initiation and progression of various types of human cancers, also including glioma.27498787
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs are a class of small endogenous non-coding RNAs that play crucial roles in the initiation and progression of human cancers.27498924
Metastasis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non-small cell lung cancer.27498924
Alzheimers DiseaseEpigenetic AlterationsCan Peripheral MicroRNA Expression Data Serve as Epigenomic (Upstream) Biomarkers of Alzheimers Disease?27501295
Admitting diagnosisEpigenetic AlterationsLittle is known, however, on the extent to which peripheral tissue (e.g., whole blood) miRNA variation might offer clinical predictive value for AD.27501295
Admitting diagnosisEpigenetic AlterationsNotably, these miRNAs are situated "upstream" to the genes implicated in AD.27501295
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLong noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression.27501756
Malignant Neoplasms, Non-Small Cell Lung CarcinomaEpigenetic AlterationsRecently, long noncoding RNAs (lncRNAs) have been identified as critical regulators in numerous types of cancers, including non-small cell lung cancer (NSCLC).27501756
Colorectal Cancer PathwayEpigenetic AlterationsCirculating microRNA-1290 as a novel diagnostic and prognostic biomarker in human colorectal cancer.27502702
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsCirculating microRNAs (miRNAs) are attracting major interest as potential non-invasive biomarkers for colorectal cancer (CRC).27502702
Carcinoma of lung, Cancer PainEpigenetic AlterationsComparison and combination of blood DNA methylation at smoking-associated genes and at lung cancer-related genes in prediction of lung cancer mortality.27503000
Heart failureEpigenetic AlterationsMicroRNAs (miRs) regulate gene expression in heart failure.27505319
EpilepsyEpigenetic AlterationsOur results also suggest for the first time that dysregulation of DNA methylation found in epilepsy is a cause rather than a consequence of this condition.27505431
Matrix Metalloproteinase 9Epigenetic AlterationsEpigenetics of Epileptogenesis-Evoked Upregulation of Matrix Metalloproteinase-9 in Hippocampus.27505431
Malignant Neoplasms, Carcinoma of lung, NeoplasmsEpigenetic AlterationsMiR-30c-2* is considered to be a tumor suppressor microRNA in various cancers and is associated with gemcitabine sensitivity of lung cancer cells.27506865
Primary malignant neoplasmEpigenetic AlterationsThe level of long interspersed nucleotide element-1 (LINE- 1) methylation is considered a surrogate marker of global DNA methylation, and is attracting interest as a good predictor of cancer prognosis.27507047
Primary malignant neoplasmEpigenetic AlterationsHowever, the mechanism how LINE-1 (global DNA) methylation is controlled in cancer cells remains to be fully elucidated.27507047
Primary malignant neoplasmEpigenetic AlterationsOur results suggest that UHRF1 is a key epigenetic regulator of DNA methylation and might be a potential target for cancer treatment.27507047
Metastasis, Malignant neoplasm of thyroidEpigenetic AlterationsLong non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF-b/Smad signaling pathway.27507052
Adenocarcinoma of lung (disorder)Epigenetic AlterationsBlood-borne miRNA profile-based diagnostic classifier for lung adenocarcinoma.27507195
Carcinoma of lung, Blood CirculationEpigenetic AlterationsAccumulated evidence indicates that various types of miRNA are aberrantly expressed in lung cancer and secreted into the bloodstream.27507195
Carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsInterestingly, this classifier also detected squamous and large cell lung carcinoma cases at relatively high rates (70.4% and 70.0%, respectively), which appears to be consistent with organ site-dependent miRNA expression in cancer tissues.27507195
Malignant neoplasm of endometriumEpigenetic AlterationsIntegrated Epigenomics Analysis Reveals a DNA Methylation Panel for Endometrial Cancer Detection Using Cervical Scrapings.27507616
Malignant neoplasm of endometrium, Primary malignant neoplasmEpigenetic AlterationsDNA methylation is a promising cancer biomarker, but limited use for detecting endometrial cancer.27507616
Primary malignant neoplasmEpigenetic AlterationsEpigenetic modifications are involved in the pathogenesis of cancer, and histone deacetylase inhibitors are considered potential therapeutic agents.27507654
Prostate Cancer Pathway, Secondary malignant neoplasm of boneEpigenetic AlterationsThere is an increasing concern in the role of microRNA (miRNA) in the pathogenesis of bone metastasis (BM) secondary to prostate cancer (CaP).27509989
Prostate Cancer PathwayEpigenetic AlterationsTargeted genes would be upregulated upon transfection of the bone metastatic prostate cancer cell line, PC3, with specific microRNA inhibitors.27509989
Primary Biliary CholangitisEpigenetic AlterationsIt has been previously reported that miRNAs are involved in drug resistance, however, the association between miRNA expression levels and refractory PBC remains to be fully elucidated.27511723
NeoplasmsEpigenetic AlterationsPrognostic value of long non-coding RNA UCA1 in human solid tumors.27517147
Childhood LeukemiaEpigenetic AlterationsWe also demonstrate that endogenous linc-223 localizes in the cytoplasm and acts as a competing endogenous RNA for miR-125-5p, an oncogenic microRNA in leukemia.27517498
Colorectal Cancer PathwayEpigenetic AlterationsSite-specific associations between miRNA expression and survival in colorectal cancer cases.27517623
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsThus, miRNA expression may alter survival after diagnosis with colorectal cancer (CRC).27517623
Malignant tumor of colonEpigenetic AlterationsTwo miRNAs infrequently expressed in the population and not previously reported were associated with survival after diagnosis with colon cancer (miR-1 HR 2.17 95% CI 1.41, 3.36; and miR-101-3p HR 3.51 95% CI 1.72, 7.15).27517623
Primary malignant neoplasmEpigenetic AlterationsAmong those diagnosed with rectal cancer, 201 miRNAs were associated with survival when the FDR q value was < 0.05.27517623
Malignant tumor of colon, Rectal CarcinomaEpigenetic AlterationsAssessment of 105 previously reported miRNAs associated with prognosis showed that four miRNAs influenced colon cancer survival and 17 influenced survival after a diagnosis with rectal cancer when raw p values were considered.27517623
Colorectal Carcinoma, Rectal CarcinomaEpigenetic AlterationsMiRNAs dysregulated for both colon and rectal cancer had a greater impact on survival after a diagnosis with rectal cancer.27517623
Colorectal Cancer PathwayEpigenetic AlterationsDownregulation of microRNA-199b predicts unfavorable prognosis and emerges as a novel therapeutic target which contributes to PP2A inhibition in metastatic colorectal cancer.27517624
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsThe tumor suppressor microRNA-199b (miR-199b) is a negative SET regulator associated with poor outcome in some human cancers.27517624
Acute Coronary Syndrome, HyperglycemiaEpigenetic AlterationsHyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages.27519051
CO-methylating acetyl-CoA synthase activityEpigenetic AlterationsMiR-223 and miR-486 prevailed in HDL2, while miR-92a predominated in HDL3, all three miRNAs discriminating between ACS and SA patients; their levels were increased in HDL from hyperglycemic ACS patients versus normoglycemic ones.27519051
Primary malignant neoplasmEpigenetic AlterationsCompared with The Cancer Genome Atlas, we found higher mutation rates in genes encoding products involved in epigenetic regulation and cell cycle regulation.27520487
Colorectal NeoplasmsEpigenetic AlterationsWe analyzed DNA methylation profiles of the digestive tract surface and the central bulk and invasive front regions of colorectal tumors.27521480
Secondary malignant neoplasm of liver, Colorectal NeoplasmsEpigenetic AlterationsWe determined the DNA methylation profiles of >450,000 CpG sites in 3 macrodissected regions of 79 colorectal tumors and 23 associated liver metastases, obtained from 2 hospitals in Spain.27521480
NeoplasmsEpigenetic AlterationsWe observed differences in DNA methylation among the 3 tumor sections; regions of tumor-host interface differed the most from the other tumor sections.27521480
Local-Regional anatomy, NeoplasmsEpigenetic AlterationsEpigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-Free and Overall Survival Times for Patients With Locoregional Cancer.27521480
Colorectal Cancer PathwayEpigenetic AlterationsWhen we calculated individual coefficients to quantify heterogeneity, we found that epigenetic homogeneity was significantly associated with short time of relapse-free survival (log-rank P = .037) and short time of overall survival (log-rank P = .026) in patients with locoregional colorectal cancer.27521480
Proteinuria, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsOur findings suggest that microRNA-217 may have an association with the development of proteinuria in type 2 diabetes patients.27522360
Diabetic Nephropathy, Inflammation, Fibrosis AssessmentEpigenetic AlterationsSerum microRNA-217 may be involved in the development of diabetic kidney disease by promoting chronic inflammation, renal fibrosis, and angiogenesis.27522360
Alzheimers DiseaseEpigenetic AlterationsIncreased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimers disease brain.27522519
Non-Small Cell Lung CarcinomaEpigenetic AlterationsSerum microRNA-135a downregulation as a prognostic marker of non-small cell lung cancer.27525941
Prostate Cancer PathwayEpigenetic AlterationsMicroRNA-132/212 Upregulation Inhibits TGF-b-Mediated Epithelial-Mesenchymal Transition of Prostate Cancer Cells by Targeting SOX4.27527117
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOR, MetastasisEpigenetic AlterationsAccumulating evidence indicates that miRNAs play critical roles in prostate cancer (PCa) metastasis and have potential use as therapeutic targets.27527117
NeoplasmsEpigenetic AlterationsHerein we assessed the contribution of the AID/APOBEC family and their associated genes given the remarkable ability of AID and APOBECs to edit DNA/RNA, and as such, providing tools for genetic and epigenetic alterations potentially leading to reprogramming of tumor cells, stroma and immune cells.27527602
Muscular Dystrophy, DuchenneEpigenetic AlterationsSerum Levels of MicroRNA-206 and Novel Mini-STR Assays for Carrier Detection in Duchenne Muscular Dystrophy.27529242
Stomach CarcinomaEpigenetic AlterationsExpression and prognostic value of microRNA-26a and microRNA-148a in gastric cancer.27529338
Liver neoplasms, Hollings Cancer CenterEpigenetic AlterationsHere, we compared N-glycan profiles of liver tumor tissues and adjacent tissues of 27 HCC patients to reveal the association between fucosylation and HCC progression, as well as verified the potential role of miRNA in regulating fucosylation.27533464
Liver carcinoma, NeoplasmsEpigenetic AlterationsComprehensive N-glycan profiles of hepatocellular carcinoma reveal association of fucosylation with tumor progression and regulation of FUT8 by microRNAs.27533464
Hollings Cancer CenterEpigenetic AlterationsThe forced expression of these miRNAs was able to induce a decrease in FUT8 levels and thereby to suppress HCC cells progression.27533464
melanomaEpigenetic AlterationsMicroRNA-21 regulates the ERK/NF-kB signaling pathway to affect the proliferation, migration, and apoptosis of human melanoma A375 cells by targeting SPRY1, PDCD4, and PTEN.27533779
diabeticEpigenetic AlterationsEpigenetic modification of the E-cadherin promoter was observed in leukocytes from diabetic subjects.27534967
ibudilastEpigenetic AlterationsmiRNA alterations correlate with IBD phenotype, apparently by controlling the down-regulation of specific mRNAs.27536783
Ulcerative ColitisEpigenetic AlterationsMicroRNAs Expression in the Ileal Pouch of Patients with Ulcerative Colitis Is Robustly Up-Regulated and Correlates with Disease Phenotypes.27536783
ibudilastEpigenetic AlterationsmicroRNAs (miRNAs) are dominant in the regulation of gene expression, and may affect IBD phenotype.27536783
CarcinogenesisEpigenetic AlterationsAbnormal DNA methylation is also known to play a crucial role in colorectal carcinogenesis.27540971
NeoplasmsEpigenetic AlterationsUrothelial cancer-associated 1 (UCA1) had been reported as the oncogenic long non-coding RNA in many tumors, but the role of UCA1 in EC is still unclear.27540975
Breast Carcinoma, Best Case Imputation TechniqueEpigenetic AlterationsLong non-coding RNA (lncRNA) H19 has been well studied playing an important role in breast cancer (BC) progress and the expression of H19 may service as a diagnostic target for BC.27540977
Admitting diagnosisEpigenetic AlterationsAs baseline population-specific epigenetic changes, that is, cytosine modifications, have been observed between AD and ED individuals, epigenetic variations in MYLK may provide insights into ARDS disparities.27543902
Non-MalignantEpigenetic AlterationsValidation of the SHOX2/PTGER4 DNA Methylation Marker Panel for Plasma-Based Discrimination between Patients with Malignant and Nonmalignant Lung Disease.27544059
Primary malignant neoplasmEpigenetic AlterationsDNA methylation biomarkers are valuable noninvasive diagnostic tools for cancer detection.27544059
Laryngeal Squamous Cell CarcinomaEpigenetic AlterationsMicroRNA-21 in laryngeal squamous cell carcinoma: Diagnostic and prognostic features.27545281
Laryngeal Squamous Cell CarcinomaEpigenetic AlterationsMicroRNA-21 was upregulated in laryngeal squamous cell carcinomas compared to adjacent nontumor tissues (P = .005).27545281
Ischemic strokeEpigenetic AlterationsHowever, there has been little research regarding miRNA expression and its involvement in ischemic stroke.27545688
Cerebrovascular accidentEpigenetic AlterationsAlso, large and small arterial strokes types demonstrated elevated miRNA-34a-5p expression levels.27545688
Cerebral artery occlusionEpigenetic AlterationsMoreover, in vivo experiment results showed significant up-regulated expression of miRNA-34a-5p in middle cerebral artery occlusion compared to controls, along with a positive correlation between miRNA-34a-5p in blood and brain (r=0.742, p<0.05).27545688
Cerebrovascular accident, Ischemic strokeEpigenetic AlterationsCONCLUSIONS Our results suggest there is a potential regulatory role of miRNA-34a-5p in acute ischemic stroke, which could serve as a therapeutic target or biomarker in stroke prognosis.27545688
melanoma, Mucosal Melanoma, Concomitant Medication Submission Domain, Methyl MethanesulfonateEpigenetic AlterationsAs opposed to cutaneous melanoma, the epigenetic mechanisms involved in the development of CM and other mucosal melanomas (MMs) are unclear.27548891
Malignant melanoma of conjunctivaEpigenetic AlterationsMicroRNA Expression Profile in Conjunctival Melanoma.27548891
MetastasisEpigenetic AlterationsChanges in miRNA expression were associated with T stage, local recurrence, metastasis, and mortality.27548891
Concomitant Medication Submission Domain, melanomaEpigenetic AlterationsOur analysis revealed 24 upregulated and 1 downregulated miRNA in CM; several of these miRNAs have key functions in the pathogenesis and progression of cutaneous melanoma.27548891
Concomitant Medication Submission DomainEpigenetic AlterationsFurthermore, the miRNA expression pattern of CM resembled that in MM.27548891
Concomitant Medication Submission Domain, NeoplasmsEpigenetic AlterationsAdditionally, we identified seven upregulated miRNAs specific for stage-T1 and stage-T2 CM, whose expression was associated with increased tumor thickness (P = 0.007), and two upregulated miRNAs (miR-3687 and miR-3916) associated with an increased risk of local recurrence.27548891
Concomitant Medication Submission DomainEpigenetic AlterationsWe identified differentially expressed and potentially prognostic miRNAs in CM.27548891
Clear-cell metastatic renal cell carcinoma, MetastasisEpigenetic AlterationsEpithelial-mesenchymal transition-associated microRNA/mRNA signature is linked to metastasis and prognosis in clear-cell renal cell carcinoma.27549611
Hemorrhagic Fever, CrimeanEpigenetic AlterationsMicroRNA expression profiles in patients with acute Crimean Congo hemorrhagic fever reveal possible adjustments to cellular pathways.27551771
Communicable Diseases, Virus DiseasesEpigenetic AlterationsSeveral viral diseases are associated with altered microRNA (miRNA) expression, which can provide vital information about how cellular pathways respond to infection.27551771
Hantavirus Infections, Dengue FeverEpigenetic AlterationsSeveral miRNAs associated with cytokine expression, some of which were previously associated with Dengue and Hantavirus infections were revealed.27551771
Osteoporosis, Postmenopausal, FractureEpigenetic AlterationsCirculating microRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures.27552543
Unknown (origin) (qualifier value)Epigenetic AlterationsEvaluation of circulating miRNA signatures in male and female subjects with idiopathic and postmenopausal osteoporotic low-traumatic fractures.27552543
Osteoporotic FracturesEpigenetic AlterationsIn particular, miR-29b-3p has previously been reported as regulator of osteogenic differentiation and could serve as a novel marker of bone turnover in osteoporotic patients as a member of a miRNA signature.27552543
Head and Neck CarcinomaEpigenetic AlterationsAberrations in Wnt and Shh signaling pathways are related to the pathogenesis of head and neck carcinomas, and their activation frequently results from epigenetic alterations.27553089
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsOur findings corroborate that the activation of Wnt signaling in head and neck squamous cell carcinoma (HNSCC) is related to epigenetic silencing of its negative regulators.27553089
Prostate Cancer Pathway, MetastasisEpigenetic AlterationsThe up-regulation of long non-coding RNA CCAT2 indicates a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial-mesenchymal transition.27558961
Primary malignant neoplasmEpigenetic AlterationsRecently, long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in human cancer biology.27558961
Breast Carcinoma, NeoplasmsEpigenetic AlterationsCirculating Tumor Cells in Breast Cancer: Correlation with Clinicopathological Parameters, Hormone Profile and MicroRNA Polymorphisms.27562388
NeoplasmsEpigenetic AlterationsNo significant associations between pre-miRNA genetic variations miR-196a2 C/T (rs11614913), miR-146a G/C (rs2910164) and miR-499 T > C (rs3746444) polymorphisms and circulating tumor cell positivity were observed.27562388
Malignant NeoplasmsEpigenetic AlterationsAberrant expression of miRNA (miR)-139-5p has been observed in various types of cancers.27562849
Primary malignant neoplasmEpigenetic AlterationsEmerging evidence suggested that microRNAs (miRNAs) play a causal role in cancer tumorigenesis.27562849
ObesityEpigenetic AlterationsEpigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic.27564309
ObesityEpigenetic AlterationsWe conclude that epigenetic modulation of SOCS3, a gene involved in leptin and insulin signaling, may play an important role in obesity and MetS.27564309
NeoplasmsEpigenetic AlterationsWe demonstrate intra-tumor expression gradients indicating a differentiated expression of the target miRNAs between functional tumor zones, but the potential role as markers of early metastatic disease is still not fully clarified.27565378
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe expression of microRNA 574-3p as a predictor of postoperative outcome in patients with esophageal squamous cell carcinoma.27565418
Squamous cell carcinoma of esophagusEpigenetic AlterationsOur results suggest that the aberrant expression of the miRNAs identified in this study plays key roles in the progression of ESCC.27565418
Squamous cell carcinoma of esophagusEpigenetic AlterationsPlasma microRNA profiles: identification of miR-23a as a novel biomarker for chemoresistance in esophageal squamous cell carcinoma.27566562
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic changes in localized gastric cancer: the role of RUNX3 in tumor progression and the immune microenvironment.27566570
Stomach CarcinomaEpigenetic AlterationsGastric cancer (GC) pathogenesis involves genetic, epigenetic and environmental factors.27566570
Primary malignant neoplasmEpigenetic AlterationsRUNX3 showed protein silencing in cancer and normal mucosa, compared to inflammatory peritumoural infiltrate in almost all cases, showing a non-lymphocytic predominant pattern and being correlated with epigenetic silencing.Our results show aberrant promoters methylation in APC, CDH1, CDKN2A, MLH1 and RUNX3 associated with GC, as well as a non-lymphocytic predominant infiltrate with high expression of RUNX3.27566570
Primary malignant neoplasmEpigenetic AlterationsIntegrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer.27566576
Primary malignant neoplasmEpigenetic AlterationsDNA methylation was regarded as the promising biomarker for rectal cancer diagnosis.27566576
Primary malignant neoplasmEpigenetic AlterationsTo identify new molecular markers for rectal cancer, we mapped DNA methylation and transcriptomic profiles in the six rectal cancer and paired normal samples.27566576
Primary malignant neoplasmEpigenetic AlterationsOur data suggests that aberrant DNA methylation of contiguous CpG sites in methylation array may be potential diagnostic markers of rectal cancer.27566576
FLT3 Internal Tandem DuplicationEpigenetic AlterationsWe found that patients with activating mutations, such as FLT3-ITD, had shorter TL, while those with mutations in epigenetic modifying enzymes, particularly IDH1 and IDH2, had longer TL.27568819
GliomaEpigenetic AlterationsReduced expression of microRNA-497 is associated with greater angiogenesis and poor prognosis in human gliomas.27569294
Malignant Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA (miR)-497 plays a tumor-suppressive role in several malignancies and is involved in glioma invasiveness and resistance to chemotherapy.27569294
Embryonic MosaicEpigenetic AlterationsOur study suggests that mechanisms in addition to X chromosome inactivation, such as germline mosaicism or epigenetics, may contribute to DC-like phenotypes present in female DKC1 mutation carriers.27570172
MS geneEpigenetic AlterationsNext-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells.27570566
SF3B1 wt AlleleEpigenetic AlterationsHere, we tried to identify the miRNAs-regulated pathways through a combination of miRNA and mRNA microarray in CD34+ cells from MDS patients.27571714
SF3B1 wt AlleleEpigenetic AlterationsWe identified 34 differentially expressed miRNAs and 1783 mRNAs in MDS.27571714
SF3B1 wt AlleleEpigenetic AlterationsIn conclusion, alteration expression of miRNAs and targeted mRNAs might have an important impact on cancer-related cellular pathways in MDS.27571714
NeoplasmsEpigenetic AlterationsMicroRNA (miRNA) expression is shown dysregulated in tumors.27571748
Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsMicroRNA-45 (miR-145) has been demonstrated to be downregulated in various cancer types including colorectal cancer (CRC).27572146
Non-Small Cell Lung CarcinomaEpigenetic AlterationsTaken together, our results indicate that decreased ER expression mediated by DNA methylation may play a role in NSCLC development.27572263
Breast Carcinoma, NeoplasmsEpigenetic AlterationsmiRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancer.27572271
Primary malignant neoplasmEpigenetic AlterationsCirculating serum microRNA-345 correlates with unfavorable pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer.27572313
Stomach CarcinomaEpigenetic AlterationsMicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3.27572553
Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miRNA) clusters are expressed universally across different types of organisms, and an accumulating number of studies have demonstrated that miRNA clusters function more efficiently compared with single miRNAs during the development of certain cancer types.27572636
Non-Small Cell Lung CarcinomaEpigenetic AlterationsPromoter hypermethylation was previously observed in NSCLC, and its epigenetic silencing, observed on mRNA or protein level, was proposed to predict NSCLC outcome.27572663
Primary malignant neoplasm, Non-Small Cell Lung CarcinomaEpigenetic AlterationsFHIT promoter hypermethylation both in cancer and control tissue indicated the presence of epigenetic alterations in early stage of NSCLC development.27572663
Aggressive behavior, Glioblastoma MultiformeEpigenetic AlterationsExpression level of miRNAs on chromosome 14q32.31 region correlates with tumor aggressiveness and survival of glioblastoma patients.27573219
Glioblastoma, NeoplasmsEpigenetic AlterationsThese miRNAs are downregulated in glioblastomas and might have a tumor suppressive role.27573219
Glioblastoma MultiformeEpigenetic AlterationsWe also determined the expression level of cluster-14-miRNAs in 27 patients with newly diagnosed glioblastoma, and analyzed the association between their level of expression and OS.27573219
Aggressive behavior, Glioblastoma MultiformeEpigenetic AlterationsThe expression level of cluster-14-miRNAs correlates directly with OS, suggesting a role for this cluster in promoting aggressive behavior of glioblastoma, possibly through ErBb/neuregulin signaling.27573219
melanomaEpigenetic AlterationsIncreasing evidence shows that miRNA can provide potential candidate biomarkers for melanoma and therapeutic targets.27573550
Liver and Intrahepatic Biliary Tract CarcinomaEpigenetic AlterationsSupposing that microRNA (miRNA) expression profiles in saliva are similar to those in serum, four miRNAs (miR-1246, miR-3976, miR-4306, and miR-4644) in salivary exosomes may also be useful for detection of pancreatobiliary tract cancer.27573701
Squamous cell carcinoma, methionineEpigenetic AlterationsThe tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma.27573718
Primary malignant neoplasmEpigenetic AlterationsRestoration of miR-23b or miR-27b in cancer cells revealed that both miRNAs significantly inhibited cancer cell migration and invasion.27573718
AdenocarcinomaEpigenetic AlterationsA comparison of miRNA profiles revealed 29 miRNAs that were differentially expressed between TRU- and non-TRU adenocarcinoma types.27575252
Adenocarcinoma, Adenocarcinoma of lung (disorder)Epigenetic AlterationsTRU- and non-TRU-type adenocarcinomas have distinct miRNA expression profiles, suggesting that tumorigenesis in lung adenocarcinoma occur via different pathways.27575252
Prostate Cancer Pathway, CarcinogenesisEpigenetic AlterationsCharacterizing aberrant DNA methylation changes associated with prostate carcinogenesis could potentially identify a tumour-specific methylation pattern, facilitating the early diagnosis of prostate cancer.27576364
Malignant NeoplasmsEpigenetic AlterationsEpigenetic silencing mediated by CpG island methylation is a common feature of many cancers.27576364
Breast CarcinomaEpigenetic AlterationsDNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA.27577081
NeoplasmsEpigenetic AlterationsDNA methylation changes in peripheral blood DNA have been shown to be associated with solid tumors.27577081
Cell InvasionEpigenetic AlterationsMicroRNA-3713 regulates bladder cell invasion via MMP9.27577949
Malignant NeoplasmsEpigenetic AlterationsDysregulation of microRNAs (miRNAs) is well known to be involved in the development of various cancers, including TCC, whereas a role of miR-3713 in the pathogenesis of TCC has not been appreciated.27577949
Primary malignant neoplasmEpigenetic AlterationsThe Piwi-piRNA pathway is important for germ cell maintenance, genome integrity, DNA methylation and retrotransposon control and thus may be involved in cancer development.27578485
Squamous cell carcinoma, NeoplasmsEpigenetic AlterationsWe previously described several abnormally expressed long non-coding RNA (lncRNA) in tong squamous cell carcinomas (TSCCs) that might be associated with tumor progression.27586393
Malignant neoplasm of urinary bladderEpigenetic AlterationsWe assessed the performance of associating a FGFR3 mutation assay and a DNA methylation analysis to improve bladder cancer detection and to predict disease recurrence of NMIBC patients.27586786
Malignant neoplasm of urinary bladderEpigenetic AlterationsNon-muscle-invasive bladder cancer (NMIBC) is a high incidence form of bladder cancer (BCa), where genetic and epigenetic alterations occur frequently.27586786
Pancreatic Intraductal Papillary Mucinous NeoplasmEpigenetic AlterationsCombining radiomic features with a miRNA classifier may improve prediction of malignant pathology for pancreatic intraductal papillary mucinous neoplasms.27589689
Acute Coronary SyndromeEpigenetic AlterationsThe role of serum levels of microRNA-21 and matrix metalloproteinase-9 in patients with acute coronary syndrome.27590242
Cardiovascular DiseasesEpigenetic AlterationsIt seems that microRNA-21 and matrix metalloproteinase-9 implicated in the pathogenesis of cardiovascular diseases.27590242
Metastasis, NeoplasmsEpigenetic AlterationsA growing body of research has shown that the dynamic expression of microRNAs (miRNAs) was intimately associated with tumor invasion and metastasis.27593563
Systemic arterial pressure, Choline Dehydrogenase, MitochondrialEpigenetic AlterationsIncreasing evidence suggests that the early life environment may act through epigenetic processes to influence later CHD risk markers such as increased arterial pulse wave velocity (PWV, a measure of arterial stiffness) blood pressure or heart rate.27594927
Choline Dehydrogenase, MitochondrialEpigenetic AlterationsOur findings suggest developmental epigenetic regulation of ANRIL promoter methylation as a factor in later CHD risk in children.27594927
Complication Aspects, PRB1 geneEpigenetic AlterationsTaken together, our findings suggest a possible role of CD18 epigenetic regulation in the pathogenesis of the thrombotic complications in PMF patients.27595148
Glioblastoma MultiformeEpigenetic AlterationsMicroRNAs (miRNA) are believed to play an important role in glioblastoma multiforme (GBM)chemotherapy.27595933
NeoplasmsEpigenetic AlterationsmiRNA-370-3p mimic increased its expression and sensitivity of GBM cells to TMZ by suppressing the self-reparative ability of tumour cell DNA.27595933
Malignant NeoplasmsEpigenetic AlterationsmiRNAs have been reported to be involved in the pathogenesis of many cancers.27596960
Malignant Neoplasms, fluorouracil/mitomycin/streptozocinEpigenetic AlterationsHere, expression deregulation of 7 miRNAs (mir204, mir31, mir31*, mir133a, mir7, mir206 and mir1293) and their possible target genes in 23 cancers, 18 LK, 12 LP, 23 OSMF tissues compared to 20 healthy tissues was determined by qPCR method.27597234
Stomach CarcinomaEpigenetic AlterationsAberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer.27598141
Stomach CarcinomaEpigenetic AlterationsTherapeutic intervention of STAT3 in reversing the epigenetic status of GATA6 could benefit the treatment of gastric cancer and is worthy of further investigation.27598141
Primary malignant neoplasmEpigenetic AlterationsAlthough its contents (e.g., proteins and microRNAs) have been focused on in cancer research, particularly as potential diagnostic markers, the exosome behavior and methods for exosome quantification remain unclear.27599779
Prostate Cancer PathwayEpigenetic AlterationsCirculating microRNA signature for the diagnosis of very high-risk prostate cancer.27601638
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsWe report the identification of a molecular signature using the Scano-miR profiling platform based on the differential expression of circulating microRNAs (miRNA, miR) in serum samples specific to patients with very high-risk (VHR) prostate cancer (PCa).27601638
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsFive miRNA PCa biomarkers (miR-200c, miR-605, miR-135a*, miR-433, and miR-106a) were identified as useful for differentiating indolent and aggressive forms of PCa.27601638
Squamous cell carcinoma of lung, Adenocarcinoma of lung (disorder), Primary malignant neoplasmEpigenetic AlterationsWe obtained epigenome-wide DNA methylation data from lung adenocarcinoma (LUAD) and lung squamous cell (LUSC) tissues in The Cancer Genome Atlas (TCGA).27602958
Degenerative polyarthritisEpigenetic AlterationsMicroRNA-9 regulates the development of knee osteoarthritis through the NF-kappaB1 pathway in chondrocytes.27603333
Degenerative polyarthritisEpigenetic AlterationsIt has been suggested that microRNA-9 (miR-9) is associated with the development of knee osteoarthritis (OA).27603333
CarcinogenesisEpigenetic AlterationsAberrant DNA methylation occurs frequently in breast carcinogenesis.27604360
Breast Carcinoma, NeoplasmsEpigenetic AlterationsWe assessed the suitability of FFPE breast cancer material for genome-wide DNA methylation assessment of tumour and ADJNT.27604360
Breast CarcinomaEpigenetic AlterationsTools for translational epigenetic studies of breast cancer involving formalin-fixed paraffin-embedded (FFPE) human tissues have now been developed.27604360
Carcinoma of lungEpigenetic AlterationsMicro RNA-98 interferes with expression interleukin-10 in peripheral B cells of patients with lung cancer.27605397
Atypical Reparative CellEpigenetic AlterationsThe results provided a potential strategy of ARC management by manipulating epigenetic changes.27607418
Breast Carcinoma, NeoplasmsEpigenetic AlterationsImportantly, the selectively enriched exosome microRNA, human miR-1246, was detected at significantly higher levels in exosomes isolated from PDX mouse plasma, indicating that tumor exosome microRNAs are released into the circulation and can serve as plasma biomarkers for breast cancer.27608715
Breast CarcinomaEpigenetic AlterationsOur results demonstrate that certain microRNA species, such as miR-21 and miR-1246, are selectively enriched in human breast cancer exosomes and significantly elevated in the plasma of patients with breast cancer.27608715
Breast CarcinomaEpigenetic AlterationsPlasma exosome microRNAs are indicative of breast cancer.27608715
Breast CarcinomaEpigenetic AlterationsmicroRNAs are promising candidate breast cancer biomarkers due to their cancer-specific expression profiles.27608715
Breast CarcinomaEpigenetic AlterationsHowever, efforts to develop circulating breast cancer biomarkers are challenged by the heterogeneity of microRNAs in the blood.27608715
Breast CarcinomaEpigenetic AlterationsTo overcome this challenge, we aimed to develop a molecular profile of microRNAs specifically secreted from breast cancer cells.27608715
Breast CarcinomaEpigenetic AlterationsCellular and exosome microRNAs from breast cancer cell lines were profiled by next-generation small RNA sequencing.27608715
Breast CarcinomaEpigenetic AlterationsSmall RNA sequencing and qRT-PCR analysis showed that several microRNAs are selectively encapsulated or highly enriched in breast cancer exosomes.27608715
Breast CarcinomaEpigenetic AlterationsThese findings indicate a potential new strategy to selectively analyze plasma breast cancer microRNAs indicative of the presence of breast cancer.27608715
Primary malignant neoplasmEpigenetic AlterationsAmong these PARP genes, poly ADP-ribose polymerase family, member 15 (PARP15) is a candidate gene for cancer development due to its ability to regulate gene transcription and its reported association with apoptosis.27610459
Primary malignant neoplasmEpigenetic AlterationsThey collected mRNA and microRNA expression profiles and gathered the corresponding clinical data of 73 BRCA patients with radiotherapy from The Cancer Genome Atlas (TCGA).27610468
Liver carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-126 inhibits tumor proliferation and angiogenesis of hepatocellular carcinoma by down-regulating EGFL7 expression.27611944
Prostate Cancer Pathway, NeoplasmsEpigenetic AlterationsNovel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer.27611943
CHOANAL ATRESIA, POSTERIOR, MetastasisEpigenetic AlterationsWe propose a novel, paradigm shifting hypothesis that this frequently deleted locus is also associated with a cluster of microRNA genes- miR-3622a/b- that are lost in PCa and play an important mechanistic role in progression and metastasis.27611943
Prostate Cancer PathwayEpigenetic AlterationsConsidering the association of chr8p21 loss with poor prognosis, our findings are highly significant and support a novel concept that associates a long standing observation of frequent loss of a chromosomal region with a novel miRNA in prostate cancer.27611943
Stomach CarcinomaEpigenetic AlterationsMicroRNA-21 promotes TGF-b1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression.27611950
Breast CarcinomaEpigenetic AlterationsCorrelation between the DNA methylation and gene expression of IGFBP5 in breast cancer.27612043
Squamous cell carcinomaEpigenetic AlterationsLong non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition.27613832
NeoplasmsEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have emerged recently as key regulators of tumor development and progression.27613832
Squamous cell carcinoma of esophagusEpigenetic AlterationsEsophageal squamous cell carcinoma (ESCC) is a fatal disease contributed by both genetic and epigenetic factors.27613842
Stomach CarcinomaEpigenetic AlterationsDiagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer.27614739
MetastasisEpigenetic AlterationsDecreased serum miRNA-206 expression was significantly associated with deep local invasion, positive lymph node metastasis, and advanced clinical stage.27614739
Primary malignant neoplasmEpigenetic AlterationsThese results suggest that serum miRNA-206 might not only serve as a novel diagnostic biomarker for GC, but also predict cancer recurrence and patients prognosis.27614739
Malignant NeoplasmsEpigenetic AlterationsRecent studies have demonstrated that microRNAs (miRNAs) can serve as useful biomarkers for human cancers.27614739
MeningiomaEpigenetic AlterationsAberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas.27614886
MeningiomaEpigenetic AlterationsTumor-related DNA methylation of the DLC1 isoform 1 alternative promoter was identified as being hypermethylated in meningiomas in genome-wide DNA methylation profiling.27614886
MeningiomaEpigenetic AlterationsAll histopathological subtypes of meningiomas showed similar and significant increase of DNA methylation levels.27614886
MeningiomaEpigenetic AlterationsHigh DNA methylation was associated with lack of DLC1 protein expression in meningiomas as determined by immunohistochemistry.27614886
Malignant neoplasm of breastEpigenetic AlterationsPortraying breast cancers with long noncoding RNAs.27617288
Primary malignant neoplasmEpigenetic AlterationsEvidence is emerging that long noncoding RNAs (lncRNAs) may play a role in cancer development, but this role is not yet clear.27617288
Malignant Neoplasms, Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have been proven to be important oncogenes and tumor suppressors in wide range of cancers, including renal cell carcinoma (RCC).27619681
melanomaEpigenetic AlterationsOur data illustrate another epigenetic mechanism activated by MS-275 at the post-transcriptional level in melanoma, in addition to its best-known effects at the transcriptional level.27620505
GammopathyEpigenetic AlterationsAberrant DNA methylation is considered a crucial mechanism in the pathogenesis of monoclonal gammopathies.27622827
Primary malignant neoplasmEpigenetic AlterationsCancer initiation and progression has been linked to aberrant expression of the DNA methyltransferases (DNMT), the enzymes which establish and maintain DNA methylation patterns throughout the genome.27623253
Vulvar NeoplasmsEpigenetic AlterationsThese observations are consistent with the possibility that epigenetic changes contribute to vulvar neoplasia and DNMT3A over-expression may be useful in predicting local disease recurrence.27623253
Gastrointestinal Stromal TumorsEpigenetic AlterationsCurrently, little is known about differences in miRNA expression between KIT/PDGFRA mutant and KIT/PDGFRA wild-type (WT)-SDH deficient gastrointestinal stromal tumors (GIST).27625077
Gastrointestinal Stromal TumorsEpigenetic AlterationsThis prompted us to perform an integrated multiple expression profile of miRNA and mRNA, constructing an original miRNA-mRNA regulatory network in KIT/PDGFRA WT-SDH deficient GIST patients.27625077
Pancreatic carcinomaEpigenetic AlterationsA panel of 13-miRNA signature as a potential biomarker for predicting survival in pancreatic cancer.27626307
Bone necrosisEpigenetic AlterationsTET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt pathway in Steroid-Associated Osteonecrosis.27627619
Coronary Artery Disease, Choline Dehydrogenase, MitochondrialEpigenetic AlterationsInterleukin-6 (IL-6) is implicated in the pathogenesis of coronary heart disease (CHD), and IL-6 expression has associated with reduced DNA methylation of its gene promoter.27627640
CarcinomaEpigenetic AlterationsTERT rs2736118 was associated with differences in miRNA expression between carcinoma and normal colonic mucosa for 75 miRNAs (FDR <0.05).27627813
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis.27628540
HIV AntigensEpigenetic AlterationsThis discovery cohort data unveils cell type-specific DNA methylation patterns related to HIV-associated CI and provide an immunoepigenetic DNA methylation "signature" potentially useful for corroborating clinical assessments, informing pathogenic mechanisms, and revealing new therapeutic targets against CI.27629381
GliomaEpigenetic AlterationsThe expression of miRNA-221 and miRNA-222 in gliomas patients and their prognosis.27629767
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe expression of miRNA-221 and miRNA-222 in human glioma cell line U87, U251, A172, LN229 and surgery resected glioma tissues were measured.27629767
Glioblastoma Multiforme PathwayEpigenetic Alterations165 cases of glioma patients were recruited successfully; the expression of miRNA-221 and miRNA-222 in their resected tissues were measured.27629767
Primary malignant neoplasmEpigenetic AlterationsThe expression of miRNA-221 and miRNA-222 in cancer tissues were obviously higher than control tissues (normal brain tissue) and control cell (gastric mucosal epithelial cell, GES) (p < 0.05).27629767
Malignant GliomaEpigenetic AlterationsThe highly malignant glioma tissues expressed significantly higher miRNA-221 and miRNA-222 than low malignant glioma tissues.27629767
Glioblastoma Multiforme PathwayEpigenetic AlterationsSurvival rate of glioma cells was significantly higher than GES cell after irradiation (p < 0.05); miRNA-221 in glioma cells.27629767
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe expressions of miRNA-221 and miRNA-222 in irritated glioma cells were positively correlated with the survival rate of glioma cells (r = 0.629, 0.712, both p < 0.01).27629767
Glioblastoma Multiforme PathwayEpigenetic AlterationsFor the 165 glioma patients, the expressions of miRNA-221 and miRNA-222 increased with the increasing of pathological grades (kh 2 = 42.85, p < 0.01); and their survival time decreased when miRNA-221 expression elevated (kh 2 = 57.12, p < 0.01).27629767
Glioblastoma Multiforme PathwayEpigenetic AlterationsMiRNA-221 and miRNA-222 express highly in human glioma cells and tissues.27629767
Squamous cell carcinoma of esophagusEpigenetic AlterationsPromoter DNA methylation of CDO1 gene and its clinical significance in esophageal squamous cell carcinoma.27629777
Chronic Lymphocytic LeukemiaEpigenetic AlterationsOur investigation suggests that epigenetic silencing of PTCH is a mechanism contributing to CLL tumorigenesis.27630290
Carcinogenesis, NeoplasmsEpigenetic AlterationsEpigenetic regulators, including Jumonji domain 2 (JMJD2/KDM4) proteins are involved in post-translational modification of histone demethylation and have a major role in carcinogenesis of many solid tumors.27630312
Malignant neoplasm of urinary bladder, Primary malignant neoplasmEpigenetic AlterationsAbnormal expression of microRNAs (miRNAs) plays an important role in development of several cancer types, including bladder cancer (BCa).27631180
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCirculating long noncoding RNA GAS5 is a novel biomarker for the diagnosis of nonsmall cell lung cancer.27631209
NeoplasmsEpigenetic AlterationsThe recently discovered long noncoding RNAs have the potential to regulate many biological processes, which are aberrantly expressed in many tumor types.27631209
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsMiRNAs are master regulators of gene expression and several biological processes, and they are dysregulated in various cancers, where they play a vital role in either cancer progression or suppression.27631726
Limited stage (cancer stage)Epigenetic AlterationsThe levels of three miRNAs (miR-22-3p, miR-642b-3p and miR-885-5p) and CA19-9 were significantly higher in PC patients, even those with early-stage disease (IB and IIB), than in healthy control.27631726
NeoplasmsEpigenetic AlterationsBoth miRNAs and CA19-9 were associated with tumor stage.27631726
Clinical CoordinatorEpigenetic AlterationsThe here identified miRNA markers, miR-122 and the miR-200 family members, could be of use in the development of a multi-marker blood test for CRC prognosis.27632639
Malignant Neoplasms, Colorectal Cancer Pathway, Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsCirculating microRNAs (miRNAs) have been proposed as minimally invasive prognostic markers for various types of cancers, including colorectal cancer (CRC), the third most diagnosed cancer worldwide.27632639
Squamous cell carcinoma of vulvaEpigenetic AlterationsLong non-coding RNA expression profile in vulvar squamous cell carcinoma and its clinical significance.27633334
Squamous cell carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsRegulation of TPD52 by antitumor microRNA-218 suppresses cancer cell migration and invasion in lung squamous cell carcinoma.27633630
Carcinoma of lung, Aggressive behaviorEpigenetic AlterationsAberrant microRNA (miRNA) expression has been shown to promote lung cancer development and aggressiveness.27633630
Malignant NeoplasmsEpigenetic AlterationsDownregulation of microRNA-218 (miR-218) was frequently observed in our miRNA expression signatures of cancers, and previous studies have shown an antitumor function of miR-218 in several types of cancers.27633630
Carcinoma of lungEpigenetic AlterationsMicroRNA-187 is an independent prognostic factor in lung cancer and promotes lung cancer cell invasion via targeting of PTRF.27634346
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are involved in the progression of different types of cancers giving new hope for cancer treatment.27634346
Malignant tumor of colonEpigenetic AlterationsOverexpression of Long Non-Coding RNA TUG1 Promotes Colon Cancer Progression.27634385
Prostate Cancer PathwayEpigenetic AlterationsOncogenic microRNA-4534 regulates PTEN pathway in prostate cancer.27634912
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsHere, we demonstrate that microRNA-4534 (miR-4534) is overexpressed in PCa and show that miR-4534 is hypermethylated in normal tissues and cell lines compared to PCa tissues/cells.27634912
CarcinogenesisEpigenetic AlterationsThese results have important implications for identifying and defining the role of new PTEN regulators such as microRNAs in prostate tumorigenesis.27634912
Malignant tumor of colonEpigenetic AlterationsAdditionally, we evaluated CTA expression in three colon cancer cell lines (CL-188, HTB-39, and HTB-37) after exposure to the DNA methylation-modifying drug 5-azacytidine.27635108
ovarian neoplasmEpigenetic AlterationsUsing customized TaqMan low density miRNA arrays, we first screened expression levels of 48 miRNAs in sera from 18 epithelial ovarian cancer patients and 16 benign ovarian tumor patients.27636713
Malignant - descriptor, ovarian neoplasmEpigenetic AlterationsArray screening data showed that expression levels of serum miRNA-20a, miRNA-125b, miRNA-126, miRNA-355, and let-7c were significantly different between malignant and benign ovarian tumor patients.27636713
ovarian neoplasmEpigenetic AlterationsSubsequent real-time polymerase chain reaction results showed that serum miRNA-125b levels were significantly higher in epithelial ovarian cancer patients compared to benign controls.27636713
ovarian neoplasm, NeoplasmsEpigenetic AlterationsMoreover, serum miRNA-125b levels were significantly higher in ovarian cancer patients in early stages I and II, and in patients having no residual tumor following surgery, but were not associated with differentiation and histological types of ovarian cancer.27636713
Carcinoma, Ovarian EpithelialEpigenetic AlterationsmiRNA-125b plays an important role in the pathogenesis and progression of epithelial ovarian cancer.27636713
ovarian neoplasmEpigenetic AlterationsCirculating miRNA-125b has the potential to become a novel biomarker for early diagnosis and prognosis prediction of epithelial ovarian cancer.27636713
Alcoholic Liver DiseasesEpigenetic AlterationsExtracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood.27639178
Alcoholic SteatohepatitisEpigenetic AlterationsHere, we tested the hypothesis that during early alcoholic steatohepatitis (ASH) development, hepatocytes (HCs) release EVs with an miRNA signature that can be measured in circulation.27639178
Colorectal Neoplasms, Sessile Serrated Adenoma/PolypEpigenetic AlterationsHuman sessile serrated adenomas and right-sided colorectal tumors with epigenetic loss of MutL homolog 1 (MLH1) had lost or had lower levels of HES1 than other colorectal tumor types or nontumor tissues.27639802
Impaired cognitionEpigenetic AlterationsThese results suggested that the DNA methylation of the SORL1 5-flanking region may significantly influence the manifestation of mild cognitive impairment in T2DM, and might be associated with its neurocognitive presentation.27641082
Primary malignant neoplasmEpigenetic AlterationsAs a special form of noncoding RNAs, circular RNAs (circRNAs) played important roles in regulating cancer progression mainly by functioning as miRNA sponge.27642589
Neuropathic pain, Feel PainEpigenetic AlterationsDeciphering miRNA-target interactions that influence inflammatory pathways in neuropathic pain may contribute to the discovery of new roads towards pain amelioration.27646435
Neuropathic painEpigenetic AlterationsWe demonstrate that microRNAs (miRNAs) are involved in the differentiation of Tregs in neuropathic pain.27646435
Chicken anemia virusEpigenetic AlterationsTo date, there are no established noninvasive biomarkers available for prediction of CAV in transplanted patients.MicroRNAs (miRNAs) are highly conserved, small noncoding RNA molecules that negatively regulate gene expression.27653298
Cardiovascular DiseasesEpigenetic AlterationsAs they are detectable in peripheral blood, recent studies have suggested miRNAs as biomarkers for various cardiovascular diseases.27653298
Chicken anemia virusEpigenetic AlterationsThus, we hypothesized that circulating miRNAs may serve as noninvasive biomarkers for CAV.27653298
Antilymphocyte SerumEpigenetic AlterationsThe understanding of the mechanisms, either genetic or epigenetic, through which exogenous factors influence disease phenotype is of major importance towards a more focused approach to cure ALS.27656044
Stage I Esophageal Squamous Cell Carcinoma AJCC v7Epigenetic AlterationsOverexpression of microRNA-1288 in oesophageal squamous cell carcinoma.27658568
Colonic PolypsEpigenetic AlterationsMicroRNA Signatures of Colonic Polyps on Screening and Histology.27658891
Colorectal Cancer Pathway, Primary malignant neoplasm, AdenomaEpigenetic AlterationsColorectal cancer and adenoma adjacent to cancer exhibit distinct microRNA (miRNA) alterations in an apparent mucosa-to-adenocarcinoma sequence.27658891
AdenomaEpigenetic AlterationsOur data support the presence of colorectal cancer-associated miRNA alterations in screen-detected adenomas that may be useful for risk stratification for surveillance interval planning.27658891
Malignant Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNAs (miRNAs) are a class of small noncoding RNAs with pivotal roles in cellular and molecular processes related to different malignancies including CLL.27659777
Chronic Lymphocytic LeukemiaEpigenetic AlterationsCirculating microRNA-192 as a diagnostic biomarker in human chronic lymphocytic leukemia.27659777
Coronary Artery DiseaseEpigenetic AlterationsCirculating MicroRNAs as Novel Diagnostic Biomarkers for Very Early-onset (<=40 years) Coronary Artery Disease.27660218
Colonic adenomas, Adenocarcinoma of large intestineEpigenetic AlterationsSEPT9 and SHOX2 DNA methylation status and its utility in the diagnosis of colonic adenomas and colorectal adenocarcinomas.27660666
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28.27661126
Clinical Coordinator, MetastasisEpigenetic AlterationsMicroRNAs (miRNAs or miRs) have been demonstrated to play crucial roles in the development, metastasis and drug resistance of CRC.27661126
Heart failureEpigenetic AlterationsCirculating microRNAs (miRNAs) emerge as potential heart failure biomarkers.27661412
Urinary tract infectionEpigenetic AlterationsIn conclusion, the measurement of circulating microRNAs in plasma from patients with renal transplants distinguishes TCMR and urinary tract infection from stable graft function.27663089
ovarian neoplasmEpigenetic AlterationsUsing an ovarian cancer cell line model, we demonstrate that functional mismatch repair increases the frequency of platinum-induced methylation.Conclusions: DNA methylation in blood at relapse following chemotherapy, and not at presentation, is informative regarding survival of patients with ovarian cancer.27663594
NeoplasmsEpigenetic AlterationsDNA methylation in blood following chemotherapy could provide a noninvasive means of monitoring patients epigenetic responses to treatment without requiring a tumor biopsy.27663594
Arteriosclerosis, Coronary Artery Disease, Acute myocardial infarctionEpigenetic AlterationsMicroRNAs (miRNAs), small non-coding RNAs, have been implicated as regulators of all mediators of atherosclerosis, and some reports have suggested increased levels in coronary artery disease (CAD) and acute myocardial infarction (AMI).27665403
Coronary Artery DiseaseEpigenetic AlterationsmiRNA-93-5p and other miRNAs as predictors of coronary artery disease and STEMI.27665403
Squamous cell carcinoma of lungEpigenetic AlterationsMicroRNAs modulate the expression of the SOX18 transcript in lung squamous cell carcinoma.27666488
Carcinoma of lung, Non-Small Cell Lung CarcinomaEpigenetic AlterationsBecause of the fact that microRNAs (miRNAs) play important roles in the initiation and progression of lung cancer, the main aim of this study was to identify the miRNAs that interact with the SOX18 transcript in NSCLC cases.27666488
Primary malignant neoplasmEpigenetic AlterationsIn conclusion, miRNAs interact with the mRNA of the SOX18 gene, but the mechanism by which they could be inhibited in cancer cells requires further examination.27666488
Primary malignant neoplasm, Liver carcinomaEpigenetic AlterationsMicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma.27666683
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsIn hepatocellular carcinoma (HCC), the master hypoxia-induced microRNA (miRNA) miR-210 is upregulated in HCC and participates in HCC progression, but its roles in hypoxia-induced HCC angiogenesis are still unknown.27666683
ovarian neoplasmEpigenetic AlterationsLong non-coding RNAs, ASAP1-IT1, FAM215A, and LINC00472, in epithelial ovarian cancer.27667152
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) are a class of non-protein coding transcripts that has gained significant attention lately due to their important biological actions and potential involvement in cancer.27667152
Breast Cancer CellEpigenetic AlterationsMicroRNA biosynthesis genes can affect the regulatory effect of global microRNAs to target mRNA and hence influence the genesis and development of human cancer.27669275
Rheumatoid ArthritisEpigenetic AlterationsMicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis.27671860
Colorectal Cancer PathwayEpigenetic AlterationsThe role of miRNA-21 and epithelial mesenchymal transition (EMT) process in colorectal cancer.27672217
Prostate Cancer PathwayEpigenetic AlterationsmicroRNA-372 Suppresses Migration and Invasion by Targeting p65 in Human Prostate Cancer Cells.27673408
Initiation, CHOANAL ATRESIA, POSTERIOR, MetastasisEpigenetic AlterationsmicroRNAs (miRNAs) play an important role in cancer initiation, progression, and metastasis, and their roles in PCa are becoming more apparent.27673408
Degenerative polyarthritisEpigenetic AlterationsMiR-98 expression is reduced in the cartilage cells of OA patients and the overexpression of miR-98 inhibits cartilage cell apoptosis, while inhibition of microRNA-98 leads to cartilage cell apoptosis.27676099
Primary malignant neoplasmEpigenetic AlterationsGenetic polymorphisms in the 3 untranslated region (UTR) targeted by miRNAs can affect the regulation of target genes and individual cancer risk.27677255
cervical cancer, Carcinoma, Ovarian EpithelialEpigenetic AlterationsPreviously, over-expression of the long noncoding RNA (lncRNA) HOTAIR has been found to be associated with the invasive and metastatic capacities of several epithelial cancers, including cervical cancer (CaCx).27683269
Lewy Bodies, DementiaEpigenetic AlterationsDNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies.27685250
Lewy Body DiseaseEpigenetic AlterationsNo correlation was observed between SCNA mRNA expression levels and blood DNA methylation rates in either DLB or healthy controls.27685250
Lewy Body DiseaseEpigenetic AlterationsEpigenetic changes at the synuclein alpha ( SNCA ) gene may be involved in DLB pathogenesis.27685250
Axonal degenerationEpigenetic AlterationsThe mutation is associated with several transcriptional changes, including a significant upregulation of another E3 ubiquitin-protein ligase, NEDD4L, and of TNFRSF21, a key regulator of axonal degeneration.27686364
Primary malignant neoplasmEpigenetic AlterationsIn order to contribute to the elucidation of the role of DNA methylation changes in acquisition of a multidrug resistant (MDR) phenotype, we also analyzed the promoter methylation patterns in drug-resistant sublines of the cancer cell lines GLC-4, SW1573, KB-3-1 and HL-60.27689338
Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsAs the promoter region and the entire transcript are embedded in a CpG island, we postulated that BM742401 is a tumor suppressor lncRNA inactivated by DNA methylation in chronic lymphocytic leukemia (CLL).27689399
Neoplasms, Chronic Lymphocytic LeukemiaEpigenetic AlterationsEpigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia.27689399
Pancreatic carcinomaEpigenetic AlterationsLong noncoding RNA uc.345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression.27689400
DiseaseEpigenetic AlterationsIncreasing evidence points to an important functional or regulatory role of long noncoding RNA in cellular processes as well as cancer diseases resulted from the aberrant lncRNA expression.27689400
Degenerative polyarthritisEpigenetic AlterationsTherefore, premature epigenetic aging according to DNA methylation changes was specific of OA cartilage, adding further evidence and insight on premature aging of cartilage as a component of OA pathogenesis that reflects damage and vulnerability.27689435
Degenerative polyarthritisEpigenetic AlterationsSpecific premature epigenetic aging of cartilage in osteoarthritis.27689435
Degenerative polyarthritisEpigenetic AlterationsBy contrast, no difference in epigenetic aging was observed in bone (0.04 years; 95% CI = -1.8 to 1.9, P = 0.3) and in blood (-0.6 years; 95% CI = -1.5 to 0.3, P = 0.2) between OA patients and controls.27689435
EpilepsyEpigenetic AlterationsExpression of microRNA-129-2-3p and microRNA-935 in plasma and brain tissue of human refractory epilepsy.27689807
melanoma, NeoplasmsEpigenetic AlterationsIn addition, RAB22A was found to be a target of miR-203, a tumor suppressive miRNA in melanoma.27690221
InfertilityEpigenetic AlterationsThe influence of aberrant sperm DNA methylation on the reproductive capacity of couples has been postulated as a cause of infertility.27692602
Metastasis, Neoplasms, Renal Cell Carcinoma PathwayEpigenetic AlterationsTumor Specific Epigenetic Silencing of Corticotropin Releasing Hormone -Binding Protein in Renal Cell Carcinoma: Association of Hypermethylation and Metastasis.27695045
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsHere we investigated hypermethylation and epigenetic silencing of the CRH-Binding Protein (CRHBP) gene in clear cell renal cell cancer (ccRCC).27695045
Malignant neoplasm of kidney, Aggressive behavior, NeoplasmsEpigenetic AlterationsWe describe for the first time tumor specific epigenetic silencing of CRHBP and statistical association with aggressive tumors thus suggesting the CRH system to contribute to the development of kidney cancer.27695045
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are regulatory molecules proven to be accurate biomarkers in cancer.27699216
Cell of ClaudiusEpigenetic AlterationsHere, we identified miRNAs predictive of progressive disease under TKI treatment through deep sequencing of 74 metastatic clear cell RCC cases uniformly treated with these drugs.27699216
seleniumEpigenetic AlterationsInsomnia symptoms were related to advanced epigenetic age (b +- SE = 1.02 +- 0.37, p = .005) after adjustments for covariates.27702440
SleeplessnessEpigenetic AlterationsSymptoms of insomnia were associated with increased epigenetic age of blood tissue and were associated with higher counts of late differentiated CD8+ T cells.27702440
Senile cataractEpigenetic AlterationsEffects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract.27703255
Senile cataractEpigenetic AlterationsHistone acetylation plays key roles in gene expression, but its effects on superoxide dismutase 1 (SOD1) expression in senile cataract remains unknown.27703255
Senile cataractEpigenetic AlterationsDecreased histone acetylation at the SOD1 promoter is associated with declined SOD1 expression in senile cataracts.27703255
Senile cataractEpigenetic AlterationsHistone acetylation plays an essential role in the regulation of SOD1 expression and in the pathogenesis of senile cataracts.27703255
Ki-1+ Anaplastic Large Cell LymphomaEpigenetic AlterationsInsights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling.27705804
NeoplasmsEpigenetic AlterationsAberrant DNA methylation patterns in malignant cells allow insight into tumor evolution and development and can be used for disease classification.27705804
Ki-1+ Anaplastic Large Cell LymphomaEpigenetic AlterationsHere, we describe the genome-wide DNA methylation signatures of NPM-ALK-positive (ALK+) and NPM-ALK-negative (ALK-) anaplastic large-cell lymphoma (ALCL).27705804
Ki-1+ Anaplastic Large Cell Lymphoma, NeoplasmsEpigenetic AlterationsWe find that ALK+ and ALK- ALCL share common DNA methylation changes for genes involved in T cell differentiation and immune response, including TCR and CTLA-4, without an ALK-specific impact on tumor DNA methylation in gene promoters.27705804
Ki-1+ Anaplastic Large Cell LymphomaEpigenetic AlterationsFurthermore, we uncover a close relationship between global ALCL DNA methylation patterns and those in distinct thymic developmental stages and observe tumor-specific DNA hypomethylation in regulatory regions that are enriched for conserved transcription factor binding motifs such as AP1.27705804
Ki-1+ Anaplastic Large Cell LymphomaEpigenetic AlterationsOur results indicate similarity between ALCL tumor cells and thymic T cell subsets and a direct relationship between ALCL oncogenic signaling and DNA methylation through transcription factor induction and occupancy.27705804
BorreliaEpigenetic AlterationsThe three Borrelia strains tested exhibited similar transcriptional profiles, and no species-specific fingerprint of transcriptional changes in fibroblasts was observed.27706261
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsGenetic and epigenetic factors contribute to PCa development and progression.27706591
Carcinogenesis, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) play an important role in carcinogenesis by regulating oncogenes and tumor suppressors.27706712
palladiumEpigenetic AlterationsWe hypothesized that epigenetic variations could be associated with PD and evaluated the DNA methylation pattern in PD patients compared to brothers or twins without PD.27709425
palladiumEpigenetic AlterationsOur findings suggest that a distinct level of PD susceptibility stems from individual, epigenetic modifications of specific genes.27709425
Malignant NeoplasmsEpigenetic AlterationsMicro-RNAs (miRNAs) play roles in the pathogenesis of several malignancies by regulating gene expression and have been recently identified as stable entities in serum.27709652
Alzheimers Disease", Parkinson DiseaseEpigenetic AlterationsAltered DNA methylation of the microtubule-associated protein tau gene correlates with the expression changes in Alzheimers disease and Parkinsons disease brains.27709663
TauopathiesEpigenetic AlterationsThis exploratory study suggests that regions other than the constitutive promoter may be involved in microtubule-associated protein tau gene regulation in tauopathies and that intron 0 hypomethylation may be a specific epigenetic signature of PSP.27709663
SchizophreniaEpigenetic AlterationsDNA methylation profiles were generated for CpG sites proximal to Val66Met, within BDNF promoter I and exon V for prefrontal cortex samples from 25 schizophrenia and 25 control subjects.27712141
SchizophreniaEpigenetic AlterationsDNA methylation of one CpG site had a marginally significant positive correlation with mRNA expression in schizophrenia subjects.27712141
SchizophreniaEpigenetic AlterationsA larger age-matched cohort with comprehensive clinical history is required to accurately identify the effects of genotype, mRNA expression and DNA methylation on schizophrenia risk.27712141
Pancreatic carcinomaEpigenetic AlterationsNew combined microRNA and protein plasmatic biomarker panel for pancreatic cancer.27713117
PsoriasisEpigenetic AlterationsIncreasing evidences indicate that the abnormal DNA methylation is involved in the pathogenesis of psoriasis.27713139
Breast CarcinomaEpigenetic AlterationsBreast cancer represents a heterogenous disease that can be divided into breast cancer subtypes due to different subsets of genetic and epigenetic abnormalities.27713152
Squamous cell carcinoma of esophagusEpigenetic AlterationsProtein-coding genes combined with long non-coding RNAs predict prognosis in esophageal squamous cell carcinoma patients as a novel clinical multi-dimensional signature.27714034
Malignant NeoplasmsEpigenetic AlterationsBoth protein-coding genes (PCGs) and long non-coding RNAs (lncRNAs) have been shown to play an important role in the development of malignant tumors.27714034
Rheumatoid ArthritisEpigenetic AlterationsLong noncoding RNA expression profile in fibroblast-like synoviocytes from patients with rheumatoid arthritis.27716329
Rheumatoid Arthritis, Right armEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have recently received wide attention as key molecules that mediate a variety of physiological and pathological processes by regulating gene expression; however, knowledge of lncRNAs in rheumatoid arthritis (RA) is limited.27716329
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsPITX2 and PANCR DNA methylation predicts overall survival in patients with head and neck squamous cell carcinoma.27716615
Parkinson DiseaseEpigenetic AlterationsParkinsons disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus.27717584
CDISC Integrated Basic Data Structure DatasetEpigenetic AlterationsRecently, microRNAs (miRNAs) have been shown to be involved in the development of IBDs.27718165
S100A4 protein, humanEpigenetic AlterationsMicroRNA-375 as a biomarker for malignant transformation in oral lesions.27720656
Cardiovascular DiseasesEpigenetic AlterationsOptimized Collection Protocol for Plasma MicroRNA Measurement in Patients with Cardiovascular Disease.27725938
Stomach CarcinomaEpigenetic AlterationsA Tumor-Specific Prognostic Long Non-Coding RNA Signature in Gastric Cancer.27727196
Primary malignant neoplasmEpigenetic AlterationsWe detected promoter methylation using quantitative methylation-specific real-time PCR and methylation-on-beads for cancer-specific genes (SOX17, TAC1, HOXA7, CDO1, HOXA9, and ZFP42).Results: DNA methylation was detected in plasma and sputum more frequently in people with cancer compared with controls (P < 0.001) for five of six genes.27729459
leukemiaEpigenetic AlterationsIn leukemias, however, both leukemic and nonleukemic cells compose circulating miRNA expression profile of peripheral blood.27730344
Primary malignant neoplasmEpigenetic AlterationsExpression of microRNAs is altered in cancer.27730344
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAlterations of expression observed in CLL patients involved miRNAs associated both with B and T lymphocyte differentiation and activation.27730344
Metabolic Diseases, Cardiovascular DiseasesEpigenetic AlterationsEpigenetic alterations have been linked to the presence of Cr, and microRNA (miRNA) expression has been implicated in the pathogenesis of metabolic diseases and cardiovascular diseases (CVDs).27731332
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDiagnostic and prognostic value of plasma microRNA-195 in patients with non-small cell lung cancer.27733164
Non-Small Cell Lung CarcinomaEpigenetic AlterationsPlasma miRNA-195 was downregulated in NSCLC patients compared with healthy controls (P < 0.001).27733164
MetastasisEpigenetic AlterationsDecreased plasma miRNA-195 expression was significantly associated with lymph node metastasis and advanced clinical stage.27733164
Non-Small Cell Lung CarcinomaEpigenetic AlterationsROC curve analysis showed that plasma miRNA-195 was a useful marker for NSCLC diagnosis.27733164
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMultivariate Cox regression analysis confirmed low plasma miRNA-195 expression as an independent unfavorable prognostic factor for NSCLC patients.27733164
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese findings indicate that plasma miRNA-195 might serve as a promising biomarker for the early detection and prognosis evaluation of NSCLC.27733164
Malignant NeoplasmsEpigenetic AlterationsRecently, circulating microRNAs (miRNAs) have been reported to be stably detectable in plasma/serum and to function as potent biomarkers in various cancers.27733164
Malignant neoplasm of endometriumEpigenetic AlterationsPrognostic and Clinical Significance of miRNA-205 in Endometrioid Endometrial Cancer.27737015
Malignant neoplasm of endometriumEpigenetic AlterationsMiRNA-205 seems to be one of the key regulators of gene expression in endometrial cancer.27737015
Malignant Neoplasms, Myometrial Invasion, NeoplasmsEpigenetic AlterationsHigher levels of miRNA-205 expression were observed in tumours with less than half of myometrial invasion and non-advanced cancers.27737015
InitiationEpigenetic AlterationsAltered expression of miRNAs may be associated with cancer initiation, progression and metastatic capabilities.27737015
NeoplasmsEpigenetic AlterationsOur results identify novel mechanisms by which epigenetic regulators can affect tumor progression and suggest that prosenescence therapies could be employed against SWI/SNF-mutated cancers.27737960
NeoplasmsEpigenetic AlterationsMutational-driven comparison with other tumor types showed that UM is very similar to pediatric tumors, characterized by very few somatic insults and, possibly, important epigenetic changes.27745836
Asthma Pathway, AllergicEpigenetic AlterationsWe sought to identify DNA methylation and gene expression changes associated with childhood allergic persistent asthma.27745942
Allergic asthmaEpigenetic AlterationsWe compared genomic DNA methylation patterns and gene expression in African American children with persistent atopic asthma (n = 36) versus healthy control subjects (n = 36).27745942
Allergic asthmaEpigenetic AlterationsGiven the strong environmental influence on both epigenetic marks and allergic asthma in children, the epigenetic alterations in respiratory epithelia might provide insight into allergic asthma.27745942
Asthma Pathway, AtopyEpigenetic AlterationsGenes differentially methylated included those with established roles in asthma and atopy and genes related to extracellular matrix, immunity, cell adhesion, epigenetic regulation, and airflow obstruction.27745942
Allergic asthmaEpigenetic AlterationsEpigenetic marks in respiratory epithelia are associated with allergic asthma and gene expression changes in inner-city children.27745942
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsPrevious studies have suggested that long non-coding RNAs (lncRNAs) may be key regulators of tumor development and progression in HCC.27748842
Childhood LeukemiaEpigenetic AlterationsIt may be involved in the development of leukemia by mediating methylation of DNA and histones.27748863
Malignant NeoplasmsEpigenetic AlterationsHOX antisense intergenic RNA (HOTAIR), a long non-coding RNA, plays an important role in the development of many types of cancers.27748863
Liver carcinomaEpigenetic AlterationsMicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2.27748890
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-455 (miR-455) has been considered as a novel cancer-related miRNA and dysregulated expression frequently occurs in various human types of cancer.27748890
cervical cancerEpigenetic AlterationsRecent research has addressed the role of microRNAs in cervical cancer.27748903
MesotheliomaEpigenetic AlterationsThis suggests that besides the exposure to asbestos other currently unknown genetic or epigenetic factors may be responsible for the high incidence of mesothelioma in BAP1-unmutated families.27751355
EpitheliomaEpigenetic AlterationsWe analysed whether the specific composition of microRNAs (miRNAs) and proteins of extracellular vesicles (EVs) that urothelial tumour cells of bladder mucosa release into the urine, could reflect their pathologic condition.27751843
Malignant neoplasm of urinary bladderEpigenetic AlterationsUsing a microarray platform containing probes for 851 human miRNAs we found 26 deregulated miRNAs in high-grade bladder cancer urine EVs, from which 23 were downregulated and 3 upregulated.27751843
Transitional cell carcinoma of bladderEpigenetic AlterationsExpression of miRNA-630 in bladder urothelial carcinoma and its clinical significance.27752905
Malignant NeoplasmsEpigenetic AlterationsMany studies informed that microRNAs (miRNAs) could function as diagnostic and prognostic indicators in several cancers.27752905
Ovarian DiseasesEpigenetic AlterationsCirculating miR-373, miR-200a, miR-200b and miR-200c were quantified in a cohort of 60 EOC patients, 20 patients with benign ovarian diseases and 32 healthy women using quantitative TaqMan MicroRNA assays.27753009
NeoplasmsEpigenetic AlterationsIn conclusion, the increased serum levels of this microRNA panel have diagnostic value for distinguishing healthy controls and benign tumors from EOC.27753009
Federation of Gynecology and ObstetricsEpigenetic AlterationsElevated levels of these cell-free microRNAs could be detected in FIGO I-II and FIGO III-IV stages, grading G1-2 and G3 and lymph node-negative and -positive EOC.27753009
Colorectal Cancer PathwayEpigenetic Alterations485 blood-derived miRNAs were profiled in serum sample pools of both colorectal cancer and healthy control.27759076
Colorectal Cancer PathwayEpigenetic AlterationsSeven candidate miRNAs chosen from profiling results as well as three previous reported reference miRNAs were validated using qPCR in 30 colorectal cancer patients and 30 healthy individuals, and thereafter analyzed by statistical algorithms BestKeeper, geNorm and NormFinder.27759076
Colorectal Cancer PathwayEpigenetic AlterationsMore interestingly, the three miRNAs validated from 485 miRNAs are derived from a single primary transcript, indicting the cluster may be highly conserved in colorectal cancer.27759076
Adenoma of large intestineEpigenetic AlterationsAlthough there is a growing interest in developing circulating microRNA (miRNA) as noninvasive diagnostic biomarkers for the detection of high-risk colorectal adenomas and early-stage CRCs, but the comparative diagnostic significance of serum vs. exosomal miRNAs remains unexplored.27760147
Adenoma of large intestineEpigenetic AlterationsDiagnostic Potential of Cell-Free and Exosomal MicroRNAs in the Identification of Patients with High-Risk Colorectal Adenomas.27760147
Adenoma of large intestineEpigenetic AlterationsWe observed that the expression of four miRNAs, miR-21, miR-29a, miR-92a, and miR-135b, was significantly higher in colorectal adenomas vs. normal colonic mucosa.27760147
Adenomatous PolypsEpigenetic AlterationsCompared to exosomal miRNAs, serum levels of miR-21, miR-29a and miR-92a are superior diagnostic biomarkers in patients with high-risk adenomatous polyps.27760147
prostatitisEpigenetic AlterationsChronic Prostatitis Affects Male Reproductive Health and Is Associated with Systemic and Local Epigenetic Inactivation of C-X-C Motif Chemokine 12 Receptor C-X-C Chemokine Receptor Type 4.27760433
Metastasis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-574-5p promotes metastasis of non-small cell lung cancer by targeting PTPRU.27761023
Malignant Neoplasms, BehaviorEpigenetic AlterationsDysregulation of microRNAs (miRNAs) has been associated with malignant behavior in a variety of cancers.27761023
Hematologic NeoplasmsEpigenetic AlterationsMicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report.27761889
Hematologic NeoplasmsEpigenetic AlterationsMicroRNA-155 (miR155), a non-coding transcript of the B-cell integration cluster (BIC) gene, has been reported to play a critical role in the pathogenesis of several types of hematologic malignancies (HMs) in which high miR155 levels have been found.27761889
ArteriosclerosisEpigenetic AlterationsInnate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo.27764724
CarcinogenesisEpigenetic AlterationsEpigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition.27764771
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-7 inhibits cell proliferation, migration and invasion in human non-small cell lung cancer cells by targeting FAK through ERK/MAPK signaling pathway.27764812
Squamous cell carcinoma of lungEpigenetic AlterationsDual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma.27765924
Aggressive behavior, Primary malignant neoplasmEpigenetic AlterationsExpression levels of miR-145-5p and miR-145-3p were markedly reduced in cancer tissues, and ectopic expression of these miRNAs inhibited cancer cell aggressiveness, suggesting that both miR-145-3p as well as miR-145-5p acted as antitumor miRNAs.27765924
Stomach CarcinomaEpigenetic AlterationsmicroRNA analysis of gastric cancer patients from Saudi Arabian population.27766962
Primary malignant neoplasmEpigenetic AlterationsThe role of small non-coding microRNAs (miRNAs) in several types of cancer has been evident.27766962
Primary malignant neoplasmEpigenetic AlterationsOnly 33 miRNAs had significant expression in early and late-stage cancer tissues.27766962
MIR200C gene, MIR27B geneEpigenetic AlterationsAfter candidate miRNAs were selected, RT-qPCR further confirmed that four miRNAs (hsa-miR-200c-3p, hsa-miR-3613, hsa-miR-27b-3p, hsa-miR-4668-5p) were significantly aberrant in GC tissues compared to the normal gastric tissues.27766962
Stomach CarcinomaEpigenetic AlterationsIn this study we provide miRNAs profile of GC where many miRNAs showed aberrant expression from normal tissues, suggesting their involvement in the development and progression of gastric cancer.27766962
Fuchs Endothelial Dystrophy, Corneal dystrophyEpigenetic AlterationsInterestingly, upregulated miRNAs in the 378 family in corneal endothelium dramatically decreased in the tissues with lower ECD with advanced gutatta, providing new insight on the pathogenesis of Fuchs endothelial corneal dystrophy.27768788
Idiopathic Pulmonary FibrosisEpigenetic AlterationsMicroRNA signatures of BAL cells and alveolar macrophages are currently lacking in IPF.27769060
Idiopathic Pulmonary Fibrosis, Fibrosis AssessmentEpigenetic AlterationsWe thus focused on microRNAs previously associated with fibrosis (miR-29a, miR-29b, miR-29c, let-7d, and miR-21) and rapid IPF progression (miR-185, miR-210, miR-302c-3p miR-376c and miR-423-5p).27769060
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level.27769862
AdenomaEpigenetic AlterationsFollow-up of these epigenetic markers is suggested to further evaluate their utility for adenoma screening or surveillance.27771773
Colorectal Carcinoma Metastatic in the LungEpigenetic AlterationsA Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.27775664
Secondary malignant neoplasm of lungEpigenetic AlterationsColorectal liver and lung metastases have a unique miRNA expression profile.27775664
Secondary malignant neoplasm of liver, NeoplasmsEpigenetic AlterationsmiRNA expression in the host tissue of colorectal liver metastases seems to be able to influence tumor progression and survival.27775664
NeoplasmsEpigenetic AlterationsmiRNAs with a significant change >2-fold between the tumor, tumor stroma, and host tissue were analyzed in all samples using RT-qPCR (11 miRNAs) and correlated with the clinical data.27775664
NeoplasmsEpigenetic AlterationsWe found a differential expression of several miRNAs between the tumor, the tumor-associated stroma, and the host tissue compartment.27775664
Carcinoma of lungEpigenetic AlterationsIntegrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection.27777637
Non-Small Cell Lung CarcinomaEpigenetic AlterationsAbnormal microRNA (miRNA) expressions and promoter methylation of genes detected in sputum may provide biomarkers for non-small lung cancer (NSCLC).27777637
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe panel of 3 miRNA biomarkers has 81.5 % sensitivity and 85.9 % specificity; the panel of 3 methylation biomarkers displays 82.9 % sensitivity and 76.4 % specificity for NSCLC detection.27777637
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWe analyze expression of 3 miRNAs (miR-21, miR-31, and miR-210) and methylation of 3 genes (RASSF1A, PRDM14, and 3OST2), which were previously identified as potential biomarkers for NSCLC, in sputum of a set of 117 stage I NSCLC patients and 174 cancer-free smokers.27777637
Primary malignant neoplasm, Squamous cell carcinoma of esophagusEpigenetic AlterationsRegulation of MMP13 by antitumor microRNA-375 markedly inhibits cancer cell migration and invasion in esophageal squamous cell carcinoma.27779648
Malignant NeoplasmsEpigenetic AlterationsAccordingly, we have sequentially identified microRNA (miRNA)-mediated metastatic pathways in several cancers.27779648
Malignant Neoplasms, Squamous cell carcinoma of esophagusEpigenetic AlterationsOur past studies of miRNA expression signatures have shown that microRNA-375 (miR-375) is frequently reduced in several types of cancers, including ESCC.27779648
Squamous cell carcinoma of esophagus, Primary malignant neoplasmEpigenetic AlterationsThe expression of miR-375 was downregulated in ESCC tissues, and ectopic expression of this miRNA markedly inhibited cancer cell migration and invasion, suggesting that miR-375 acted as an antimetastatic miRNA in ESCC cells.27779648
Squamous cell carcinoma of esophagusEpigenetic AlterationsOur strategies for miRNA target searching demonstrated that matrix metalloproteinase 13 (MMP13) was directly regulated by miR-375 in ESCC cells.27779648
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are a class of small, well-conserved, non-coding RNAs that are increasingly identified as diagnostic and prognostic biomarkers in a number of cancers.27779679
NeoplasmsEpigenetic AlterationsOverexpression of miRNA-148a and knockdown of INO80 acted synergistically to decrease the expression of stem cell marker genes as well as to attenuate stem cell-specific properties including the ability to form tumors.27779717
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) have recently been found as an important class of cellular regulators of ATC carcinogenesis.27779717
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAssociation of cigarette smoking and microRNA expression in rectal cancer: Insight into tumor phenotype.27780077
Clinical Coordinator, Colorectal CarcinomaEpigenetic AlterationsOur sample consisted of 1447 CRC cases that had normal colorectal mucosa and carcinoma miRNA data and lifestyle data.27780077
NeoplasmsEpigenetic AlterationsOur results suggest that cigarette smoking can alter miRNA expression and, given associations with CIMP high and MSI tumor molecular phenotype, it is possible that smoking influences tumor phenotype through altered miRNA expression.27780077
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsOf the 306 unique miRNAs associated with cigarette smoking, 41 were inversely associated and 200 were directly associated with CIMP high or MSI tumor molecular phenotype for either colon or rectal cancer.27780077
Breast Carcinoma, Aggressive behaviorEpigenetic AlterationsThe long non-coding RNA 91H increases aggressive phenotype of breast cancer cells and up-regulates H19/IGF2 expression through epigenetic modifications.27780718
Breast CarcinomaEpigenetic AlterationsTaken together, overexpression of 91H in breast cancer and 91H-induced epigenetic modifications on H19/IGF2 locus suggest that 91H may play essential role in breast cancer development.27780718
Decompensated cirrhosis of liverEpigenetic AlterationsDecompensated cirrhosis is associated to extensive post-transcriptional changes of human albumin (HA).27782157
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsAberrant DNA methylation frequently occurs in malignant tumors but it scarcely occurs in benign tumors.27788211
NeoplasmsEpigenetic AlterationsDifferentially expressed mature miRNAs were identified between patients with or without tumor recurrence.27788488
Pathologic mineralization, Aortic valve disorderEpigenetic AlterationsAltered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1.27789555
Aortic valve disorderEpigenetic AlterationsMultidimensional genomic profiling was performed in human aortic valves to document the expression of lncRNAs and the DNA methylation pattern in calcific aortic valve disease.27789555
Aortic valve disorderEpigenetic AlterationsThese findings indicate that a dysregulation of DNA methylation in the promoter of H19 during calcific aortic valve disease is associated with a higher expression of this lncRNA, which promotes an osteogenic program by interfering with the expression of NOTCH1.27789555
Breast CarcinomaEpigenetic AlterationsmiRNAs are noncoding RNAs with abnormal expression in breast cancer; their expression in high-risk benign breast tissue may relate to breast cancer risk.27789587
NeoplasmsEpigenetic AlterationsSeven miRNAs were differentially expressed in tumors and CUBs versus reduction mammoplasty samples.27789587
NeoplasmsEpigenetic AlterationsLike many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing.27791400
NeoplasmsEpigenetic AlterationsIn all, miR-203a and miR-203b may function as tumor suppressive miRNAs, and reactivation of miR-203a may have therapeutic potential and may be used as prognostic marker for GCA patients.27791400
Malignant neoplasm of stomach stage IVEpigenetic AlterationsMiRNA-3978 regulates peritoneal gastric cancer metastasis by targeting legumain.27793040
Malignant NeoplasmsEpigenetic AlterationsEpigenetic modification and dysregulation affecting the HIC1/SIRT1 axis is potentially important for the development of malignancies.27793057
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsDysregulation of miRNA expression may be used as a biomarker for specific tumours because it may contribute to development of cancer.27797225
Breast CarcinomaEpigenetic AlterationsCirculating miRNA profiles have been highlighted for their potential as predictive markers in heterogeneous diseases such as breast cancer.27797225
AdenocarcinomaEpigenetic AlterationsDNA Methylation of PITX2 and PANCR Is Prognostic for Overall Survival in Patients with Resected Adenocarcinomas of the Biliary Tract.27798672
Metastatic Unresectable CarcinomaEpigenetic AlterationsPrognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer.27798874
NeoplasmsEpigenetic AlterationsMicroRNA (miR)-21 is overexpressed in most solid tumors and a high expression of miR-21 in tumor tissue is associated with a poor clinical outcome.27798874
Autoimmune thrombocytopeniaEpigenetic AlterationsThe aberrant expression of microRNAs and correlations with T cell subsets in patients with immune thrombocytopenia.27802180
Squamous cell carcinoma of esophagusEpigenetic AlterationsSerum microRNA-15a level acts as a potential diagnostic and prognostic biomarker for human esophageal squamous cell carcinoma.27802201
Colorectal Cancer PathwayEpigenetic AlterationsPolymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients.27803053
Primary malignant neoplasmEpigenetic AlterationsWe hypothesized that genetic variations in miRNA binding sites located in mucin genes may modulate signaling response and the maintenance of genomic stability ultimately affecting cancer susceptibility, efficacy of chemotherapy and survival.27803053
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsHigh consumption of fruit and vegetables offers an advantage in survival among the rising number of men living after a PCa diagnosis, possibly through the epigenetic effect of some nutrients.27805317
Renal Cell Carcinoma PathwayEpigenetic AlterationsLong noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF-b1/p38/HSP27 signaling in renal cell carcinoma.27806310
Malignant NeoplasmsEpigenetic AlterationsAntisense long noncoding RNAs (lncRNAs) are reported to play a regulating role in carcinogenesis of various human malignancies.27806310
CarcinogenesisEpigenetic AlterationsAberrant DNA methylation has been implicated in prostate carcinogenesis.27808252
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe microRNA-635 suppresses tumorigenesis in non-small cell lung cancer.27810784
ovarian neoplasmEpigenetic AlterationsMicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival.27811362
Neoplastic disease, NeoplasmsEpigenetic AlterationsNumerous studies suggest that microRNAs are key regulators of many fundamental biological processes, including neoplasia and tumor progression.27811362
ovarian neoplasmEpigenetic AlterationsThe potential role of microRNAs in ovarian cancer has attracted much attention in recent years.27811362
Disease, Primary malignant neoplasmEpigenetic AlterationsmiR-222 is one of those miRNAs that has attracted much attention for its multiple roles in human diseases, especially cancer.27811362
Malignant Mesothelioma of PeritoneumEpigenetic AlterationsGenomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.27813512
Malignant neoplasm of urinary bladderEpigenetic AlterationsWe aimed to assess the diagnostic potential of epigenetic changes in urine DNA from bladder cancer cases at various clinico-pathological stages of the disease.27814275
NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs) plays an important role in tumor development and progression and act as oncogenes or tumor suppressor genes in the carcinogenesis process.27814278
Admitting diagnosisEpigenetic AlterationsThe discovery of extracellular microRNAs (miRNAs) in CSF raises the possibility that miRNA may serve as novel biomarkers of AD.27814298
Primary malignant neoplasmEpigenetic AlterationsIn addition, there is a great demand for novel biomarkers for the prognosis of cancer, which prompted us to transfer a high content miRNA screening initially performed to identify bioprocess relevant miRNAs in Chinese hamster ovary (CHO) cells to human cancer cell lines .27821806
NeoplasmsEpigenetic AlterationsThe installation of de novo tumor suppressive function by using pro-apoptotic miRNAs might be a promising therapeutic approach.27821806
Ovarian CarcinomaEpigenetic AlterationsThe recovery rate of apoptosis inducing miRNAs was highest in the human ovarian carcinoma cell line SKOV3.27821806
Cessation of lifeEpigenetic AlterationsEctopic introduction of these miRNAs lead to enhanced activation of caspase-dependent death signaling and an induction of the pro-apoptotic proteins Bak1 and Bax and a reduced expression of Bcl2 and Bcl-xL.27821806
ovarian neoplasmEpigenetic AlterationsInvestigation on tissue specific effects of pro-apoptotic micro RNAs revealed miR-147b as a potential biomarker in ovarian cancer prognosis.27821806
Ulcerative ColitisEpigenetic AlterationsDownregulation of MicroRNA-21 in Colonic CD3+ T Cells in UC Remission.27824649
Ulcerative Colitis, ibudilast, Inflammatory Bowel DiseasesEpigenetic AlterationsIn active inflammatory bowel disease (IBD), microRNA expression profiling consistently features disease-specific signatures, and microRNA-21 (miR-21) has been shown to be upregulated in the inflamed colon of patients with active ulcerative colitis (UC).27824649
Non-Small Cell Lung CarcinomaEpigenetic AlterationsTwo novel BRM promoter polymorphisms (BRM-741 and BRM-1321) are associated with reversible epigenetic silencing of BRM protein expression.Experimental Design: Advanced NSCLC patients from the Princess Margaret (PM) cohort study and from the CCTG BR.24 clinical trial were genotyped for BRM promoter polymorphisms.27827316
Carcinoma of lungEpigenetic AlterationsWe find that the expression of piRNAs encoded at DLK1-DIO3 enhances the prognostic potential of small non-coding RNAs specific to this locus in predicting patient outcome, further emphasizing the importance of regulation at this locus in lung cancer.27829231
Lung diseasesEpigenetic AlterationsDeregulated expression of a microRNA (miRNA) cluster mapping to this locus was also associated with patient outcome, suggesting the importance of this locus to lung cancer disease phenotypes.27829231
Malignant Neoplasms, cervical cancerEpigenetic AlterationsIt has been reported that miRNAs is deregulated in diverse human cancers, involving human cervical cancer.27829233
Feel PainEpigenetic AlterationsAre Epigenetic Factors Implicated in Chronic Widespread Pain?27832094
Breast CarcinomaEpigenetic AlterationsGenome-wide miRNA expression may be useful for predicting breast cancer risk and/or for the early detection of breast cancer.27833082
Breast CarcinomaEpigenetic AlterationsAmong the 41 miRNA, 20 miRNAs were detectable in serum, and predicted breast cancer occurrence within 18 months of blood draw (accuracy 53%, P=0.06).27833082
Breast CarcinomaEpigenetic AlterationsThese results serve as proof-of-principle that miRNAs in women without breast cancer may be useful for predicting breast cancer risk and/or as an adjunct for breast cancer early detection.27833082
Glioblastoma Multiforme PathwayEpigenetic AlterationsKnockdown of long non-coding RNA CCAT2 suppressed proliferation and migration of glioma cells.27833083
Leukemia, Myelocytic, AcuteEpigenetic AlterationsThus we assessed genome-wide genetic, transcriptional and epigenetic alterations in BM-MSC derived from AML patients (AML BM-MSC).27833093
Papillary thyroid carcinomaEpigenetic AlterationsLong intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer.27833134
NeoplasmsEpigenetic AlterationsA number of long non-coding RNAs (lncRNAs) have been found to play critical roles in oncogenesis and tumor progression.27833134
Primary malignant neoplasmEpigenetic AlterationsIt has been reported that miRNA-22 (miR-22) is involved in the invasion of some cancer cell lines.27834627
AstrocytomaEpigenetic AlterationsPromotion of astrocytoma cell invasion by micro RNA-22 targeting of tissue inhibitor of matrix metalloproteinase-2.27834627
Ischemic strokeEpigenetic AlterationsAlthough peripheral blood mRNA and micro-RNA change after ischemic stroke, any role for long noncoding RNA (lncRNA), which comprise most of the genome and have been implicated in various diseases, is unknown.27834745
Cerebrovascular accidentEpigenetic AlterationsAltered Expression of Long Noncoding RNAs in Blood After Ischemic Stroke and Proximity to Putative Stroke Risk Loci.27834745
Right armEpigenetic AlterationsMicroRNAs have emerged as crucial regulators of the immune system, whose expression is deregulated in RA.27834806
Rheumatoid ArthritisEpigenetic AlterationsX-Linked miRNAs Associated with Gender Differences in Rheumatoid Arthritis.27834806
Right armEpigenetic AlterationsX-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention.27834806
Squamous cell carcinoma of lungEpigenetic AlterationsIdentification of a seven-miRNA signature as prognostic biomarker for lung squamous cell carcinoma.27835574
Primary malignant neoplasmEpigenetic AlterationsTwelve of the 133 most significantly altered miRNAs were associated with overall survival (OS) across different clinical subclasses of the Cancer Genome Atlas (TCGA) LUSC cohort.27835574
NeoplasmsEpigenetic AlterationsMost significantly altered miRNAs were identified between tumor and normal samples.27835574
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsIn tumor lesions of ARL4C-positive lung SCC, 5hmC was frequently detected and DNA methylation in the 3-UTR of ARL4C gene was lower than in non-tumor regions, which were consistent with the Cancer Genome Atlas dataset.27835592
Squamous cell carcinoma of lungEpigenetic AlterationsEpigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma.27835592
Malignant Neoplasms, Stomach Carcinoma, NeoplasmsEpigenetic AlterationsRecent evidence shows that miRNAs are dysregulated in a variety of cancers including gastric cancer (GC), and emerging as key oncogenes or tumor suppressors.27835599
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been suggested to have important causal roles in gastric cancer.27835598
Hollings Cancer CenterEpigenetic AlterationsThe miRNA profiles of CD90+ and CD90- HCC cells were analyzed using a miRNA microarray and quantitative real-time PCR (qRT-PCR).27835990
Hollings Cancer CenterEpigenetic AlterationsMicroRNAs (miRNAs) play crucial roles regulating CD133+ and EpCAM+ CSCs in HCC, although it is unclear whether miRNAs regulate CD90+ CSCs in HCC.27835990
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsPurpose: Epigenetic silencing of tumor suppressor genes (TSG) is an acquired abnormality observed in cancer and is prototypically linked to DNA methylation.27836862
Spinal FracturesEpigenetic AlterationsExpression of microRNAs that regulate bone turnover in the serum of postmenopausal women with low bone mass and vertebral fractures.27836951
Cardiovascular DiseasesEpigenetic AlterationsDNA methylation has been shown to regulate inflammatory pathways that are responsible for the development of cardiovascular diseases.27838013
Breast CarcinomaEpigenetic AlterationsCirculating microRNAs (miRNAs) are increasingly recognized as strong biomarkers, and we previously developed a 9-miRNA profile using serum and LNA-based qPCR that effectively stratified patients with early stage breast cancer vs. healthy women.27839676
Breast CarcinomaEpigenetic AlterationsThe performance of the circulating 9-miRNA profile was analyzed in 116 of these women, including 36 with breast cancer (aged 50-74), following a standardized protocol that mimicked a routine clinical set-up.27839676
Breast CarcinomaEpigenetic AlterationsWe propose that this miRNA profile combined with mammography will increase the overall accuracy of early detection of breast cancer.27839676
Liver carcinomaEpigenetic AlterationsLow levels of circulating microRNA-26a/29a as poor prognostic markers in patients with hepatocellular carcinoma who underwent curative treatment.27839726
Movement DisordersEpigenetic AlterationsOur findings support the potential of miRNA panels as biomarkers for movement disorders and may provide more insights into the pathological mechanisms related to these disorders.27844283
Cerebellar degeneration, Cerebellar AtaxiaEpigenetic AlterationsIn MSA, we also observed that miR-24 and miR-148b correlated with cerebellar ataxia symptoms, suggesting that these miRNAs are involved in cerebellar degeneration in MSA.27844283
Primary malignant neoplasmEpigenetic AlterationsAnalyzing gene expression and DNA methylation in The Cancer Genome Atlas cohort revealed an inverse correlation of gene expression and DNA methylation, suggesting that DNA hypermethylation is regulating the expression of UQCRC1 and UQCRFS1.27845902
Stomach CarcinomaEpigenetic AlterationsSLC7A5, who is also named LAT-1, has been validated as a promoter regulated by miRNA-126 in our previous research for gastric cancer cells.27846244
Cerebral InfarctionEpigenetic AlterationsPlasma MicroRNA-16 Is a Biomarker for Diagnosis, Stratification, and Prognosis of Hyperacute Cerebral Infarction.27846323
Cerebrovascular accidentEpigenetic AlterationsMicroRNAs (miRNAs) that regulate gene expression following stroke have potential use as prognostic markers of HACI.27846323
Inflammatory Bowel DiseasesEpigenetic AlterationsMicroRNA panels show promise as diagnostic biomarkers for the subtyping of inflammatory bowel disease.27855604
ibudilastEpigenetic AlterationsKnowledge of microRNAs in IBD has expanded recently and supports that microRNAs play an important role.27855604
Ulcerative ColitisEpigenetic AlterationsAmong them, a panel of 11 microRNAs was aberrantly expressed between UC and CD.27855604
Ulcerative ColitisEpigenetic AlterationsIdentification of differentially expressed microRNAs in UC and CD supports the hypothesis that UC and CD are regulated by distinct pathophysiologic mechanisms.27855604
Colorectal Cancer PathwayEpigenetic AlterationsSingle nucleotide polymorphisms within MicroRNAs, MicroRNA targets, and MicroRNA biogenesis genes and their impact on colorectal cancer survival.27859935
Malignant tumor of colonEpigenetic AlterationsWe have shown that single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, miRNA target genes, and miRNA biogenesis genes minimally contribute to colon cancer risk.27859935
Injury of liverEpigenetic AlterationsSerum miRNA-122 combined with albumin accurately identified subjects who died within 6 months of drug induced liver injury.27860186
Injury of liverEpigenetic AlterationsProfiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance.27860186
Cessation of lifeEpigenetic AlterationsLower levels of miRNAs-122, -4463 and -4270 were associated with death within 6 months (P<.05).27860186
Carcinoma of lung, NeoplasmsEpigenetic AlterationsMicroRNA-383 is a tumor suppressor in human lung cancer by targeting endothelial PAS domain-containing protein 1.27862077
Malignant NeoplasmsEpigenetic AlterationsThe role of microRNA (miR)-383 has been controversial in the initiation and progression of different cancers.27862077
Carcinoma of lungEpigenetic AlterationsMicroRNA-383 levels were analyzed in noncancerous versus cancerous human lung tissues and in normal versus lung cancer cell lines.27862077
Carcinoma of lungEpigenetic AlterationsMicroRNA-383 was downregulated in lung cancer tissue and cell lines.27862077
Carcinoma of lung, NeoplasmsEpigenetic AlterationsMicroRNA-383 is a tumor suppressor in human lung cancer by inhibiting EPAS1, both of which could serve as potential therapeutic targets in the treatment of lung cancer.27862077
Carcinoma of lung, NeoplasmsEpigenetic AlterationsMicroRNA-383 is a tumor suppressor in human lung cancer, which functions to inhibit tumorigenesis of lung cancer cells both in vitro and in vivo.27862077
Carcinoma of lungEpigenetic AlterationsBoth microRNA-383 and EPAS1 could serve as potential therapeutic targets in the treatment of lung cancer.27862077
Aggressive behavior, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsZFP36L2 promotes cancer cell aggressiveness and is regulated by antitumor microRNA-375 in pancreatic ductal adenocarcinoma.27862697
Malignant NeoplasmsEpigenetic AlterationsExpression of microRNA-375 (miR-375) was significantly reduced in miRNA expression signatures of several types of cancers, including PDAC.27862697
Malignant NeoplasmsEpigenetic AlterationsAlthough initially thought to be transcriptional noise, long noncoding RNAs (lncRNAs) are gaining increased attention in human cancers as its diversity function.27863388
Malignant neoplasm of urinary bladderEpigenetic AlterationsA panel of 46 microRNAs significantly associated with bladder cancer were subsequently monitored in an independent cohort of 121 subjects (61 with active BCa) using quantitative real-time PCR (RT-PCR).27863434
Malignant Neoplasms, Breast Carcinoma, Metastasis, NeoplasmsEpigenetic AlterationsMicroRNAs are non-protein coding molecules that play a key role in oncogenesis, tumor progression, and metastasis in many types of malignancies including breast cancer.27864119
NeoplasmsEpigenetic AlterationsPolycomb chromobox (CBX) proteins participate in the polycomb repressive complex (PRC1) that mediates epigenetic gene silencing and endows PRC1 with distinct oncogenic or tumor suppressor functions in a cell-type-dependent manner.27864346
Primary malignant neoplasmEpigenetic AlterationsDisruption of epigenetic regulation and characteristic metabolic alterations (known as the Warburg-effect) are well-known hallmarks of cancer.27864740
Hematologic Neoplasms, Childhood LeukemiaEpigenetic AlterationsOur results suggest that Warburg-effect related microRNAs may have important role in the pathogenesis of leukemia, and the potential oncogenic property of HDAC4 and SIRT6 cannot be excluded in hematological malignancies.27864740
Chronic Obstructive Airway DiseaseEpigenetic AlterationsReduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.27868302
Diabetes MellitusEpigenetic AlterationsWe hypothesize that the levels of specific cytokines and miRNAs vary across the diabetes spectrum and unique signatures associated with them may serve as early biomarkers of the disease and provide insights into respective pathogenetic mechanisms.27869909
Prediabetes syndromeEpigenetic AlterationsOur data suggest that changes in circulating miRNAs and cytokines may have clinical utility as biomarkers of prediabetes.27869909
Breast CarcinomaEpigenetic AlterationsPurpose Epigenetic alterations measured in blood may help guide breast cancer treatment.27870562
Primary malignant neoplasmEpigenetic AlterationsA New MicroRNA Expression Signature for Cervical Cancer.27870701
cervical cancerEpigenetic AlterationsThe potential of microRNAs as novel biomarkers in cervical cancer is growing.27870701
Infection caused by Helicobacter pyloriEpigenetic AlterationsHelicobacter pylori infection induces aberrant DNA methylation in gastric mucosa.27871161
Chronic Kidney DiseasesEpigenetic AlterationsIdentification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease.27872161
DiseaseEpigenetic AlterationsNext-generation sequencing approaches have revealed that exosomes are enriched in noncoding RNAs and thus exhibit great potential for sensitive nucleic acid biomarkers in various human diseases.27872161
Chronic Kidney DiseasesEpigenetic AlterationsThereby, miRNA-181a appeared as the most robust and stable potential biomarker, being significantly decreased by about 200-fold in exosomes of CKD patients compared to healthy controls.27872161
Malignant tumor of colon, Postoperative cognitive dysfunctionEpigenetic AlterationsPreoperative Serum MicroRNA-155 Expression Independently Predicts Postoperative Cognitive Dysfunction After Laparoscopic Surgery for Colon Cancer.27872469
Malignant tumor of colon, Osteochondritis DissecansEpigenetic AlterationsCONCLUSIONS The serum expression of miRNA-155 is an independent predictive factor for POCD after laparoscopic surgery for colon cancer.27872469
Malignant neoplasm of endometriumEpigenetic AlterationsWe used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively).27874289
Endometrial NeoplasmsEpigenetic AlterationsWe identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors.27874289
Endometrial CarcinomaEpigenetic AlterationsEpigenetic changes as prognostic predictors in endometrial carcinomas.27874289
Malignant NeoplasmsEpigenetic AlterationsThe Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers.27875818
Myeloid Leukemia, ChronicEpigenetic AlterationsThe role of long noncoding RNA HOTAIR in the acquired multidrug resistance to imatinib in chronic myeloid leukemia cells.27875938
Right armEpigenetic AlterationsFunctional evidence is still lacking but the results reinforce further study of epigenetic modifications influencing the progression of RA.27876072
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsFusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-kB, and Up-regulating Expression of MicroRNA-21.27876571
Genus FusobacteriumEpigenetic AlterationsFusobacterium nucleatum activates Toll-like receptor 4 signaling to MYD88, leading to activation of the nuclear factor-kB and increased expression of miR21; this miRNA reduces levels of the RAS GTPase RASA1.27876571
cervical cancerEpigenetic AlterationsMicroRNA-362 is downregulated in cervical cancer and inhibits cell proliferation, migration and invasion by directly targeting SIX1.27878258
Carcinogenesis, cervical cancerEpigenetic AlterationsMounting evidence demonstrates that microRNAs play important roles in the carcinogenesis and progression of cervical cancer.27878258
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsAberrant expression of microRNAs has been identified as regulators of biological processes of hepatocellular carcinoma (HCC) by negatively regulating protein-coding mRNAs.27878280
Malignant Neoplasms, Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsLong non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) significantly contributes to the progression of many human cancers, while glioma stem cells (GSCs) are believed to be responsible for tumor progression.27878295
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood, NeoplasmsEpigenetic AlterationsMicroRNA-148a (miR-148a) has been reported to be deregulated in different tumor types, whereas the biological function of miR-148a in renal cell carcinoma (RCC) largely remains unexplored.27878305
Transitional cell carcinoma of bladderEpigenetic AlterationsLong noncoding RNA GAS5 inhibits malignant proliferation and chemotherapy resistance to doxorubicin in bladder transitional cell carcinoma.27878359
Metastasis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsHigh expression of long non-coding RNA ATB indicates a poor prognosis and regulates cell proliferation and metastasis in non-small cell lung cancer.27878433
Respiratory Distress Syndrome, NewbornEpigenetic AlterationsTemporal Changes in Microrna Expression in Blood Leukocytes from Patients with the Acute Respiratory Distress Syndrome.27879560
Respiratory Distress Syndrome, AdultEpigenetic Alterations21 miRNA were expressed at increased levels in blood leukocytes at the onset of ARDS compared with healthy controls.27879560
Respiratory Distress Syndrome, Adult, InflammationEpigenetic AlterationsExpression of miRNA is increased in blood leukocytes of patients with ARDS at day 0 and day 3 and rises further by day 7, when systemic inflammation is subsiding.27879560
Idiopathic Pulmonary FibrosisEpigenetic AlterationsPlasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis.27881157
Idiopathic Pulmonary FibrosisEpigenetic AlterationsA combination of these two miRNAs may be a potential biomarker for AE-IPF from IPF.27881157
Axis, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsAn miRNA-DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia.27881579
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsPurpose: Azacitidine inhibits DNA methyltransferases, including DNMT1, and is currently the standard of care for patients with higher-risk myelodysplastic syndrome (HRMDS) or low blast count acute myeloid leukemia (AML).Experimental Design: The expression of 754 miRNAs was compared in azacitidine-resistant and azacitidine-sensitive myelodysplastic syndrome cells.27881579
Alzheimers DiseaseEpigenetic AlterationsCircadian alterations during early stages of Alzheimers disease are associated with aberrant cycles of DNA methylation in BMAL1.27883893
Admitting diagnosisEpigenetic AlterationsWe hypothesized that aberrant DNA methylation may affect circadian rhythms in AD.27883893
Admitting diagnosisEpigenetic AlterationsHence, aberrant epigenetic patterns may be linked to circadian alterations in AD.27883893
Malignant neoplasm of esophagusEpigenetic AlterationsMicroRNAs have been associated with prognosis in oesophageal cancer (EC), suggesting that miRNAs could play a role in guiding treatment decisions.27885434
Rheumatoid ArthritisEpigenetic AlterationsDNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis.27885849
Right armEpigenetic AlterationsDNA methylation at diagnosis is associated with disease-modifying antirheumatic drug treatment response in early RA.27885849
Post-Traumatic Stress DisorderEpigenetic AlterationsSubjects with PTSD showed a higher DNA methylation of four CpG sites at the BDNF promoter compared with those without PTSD.27886370
Post-Traumatic Stress DisorderEpigenetic AlterationsThis study demonstrated an association between higher DNA methylation of the BDNF promoter and PTSD diagnosis in combat-exposed individuals.27886370
Post-Traumatic Stress DisorderEpigenetic AlterationsEpigenetic alterations of the BDNF gene in combat-related post-traumatic stress disorder.27886370
Nerve Degeneration, Primary malignant neoplasmEpigenetic AlterationsEpigenetic modifications to cytosine are known to alter transcriptional states and deregulate gene expression in cancer, embryonic development, and most recently in neurodegeneration.27889911
Admitting diagnosis, Nerve DegenerationEpigenetic AlterationsThese data suggest alterations in epigenetic regulation of genes may play an early role in the progression of AD as well as other types of neurodegeneration.27889911
SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsMoreover, aberrant DNA methylation was also found as a dominant mechanism of disease progression in myelodysplastic syndrome (MDS).27891827
Malignant Neoplasms, Childhood LeukemiaEpigenetic AlterationsEpigenetic inactivation of GPX3 has been identified in various cancers including leukemia.27891827
BehaviorEpigenetic AlterationsAberrant DNA methylation seems to be associated with prostate cancer behavior.27892790
Non-Small Cell Lung CarcinomaEpigenetic AlterationsGenetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression.27893417
Non-Small Cell Lung CarcinomaEpigenetic AlterationsTogether, our combined results elucidated genetic and epigenetic silencing of miR-506-3p enhances COTL1 oncogene expression to foster NSCLC progression.27893417
Non-Small Cell Lung CarcinomaEpigenetic AlterationsImportantly, we also found GATA3 transcriptionally actives miR-506-3p expression, and the long non-coding RNA urothelial carcinoma-associated 1 (UCA1) exerts oncogenic function in NSCLC by competitively sponging miRNA-506.27893417
Malignant Neoplasms, Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsAlthough previous studies suggested that microRNA-506-3p (miR-506-3p) was frequently downregulated, and functioned as a tumor suppressor in several cancers, the biological role and intrinsic regulatory mechanisms of miR-506-3p in non-small cell lung cancer (NSCLC) remain elusive.27893417
Squamous cell carcinoma of esophagusEpigenetic AlterationsThese results indicate that aberrant DNA methylation may be a potential biomarker for the diagnosis of ESCC.27893424
Hollings Cancer CenterEpigenetic AlterationsWe screened a microRNA (miRNA) microarray to identify potential serum biomarkers for BM in HCC patients.27893432
Prostate Cancer PathwayEpigenetic AlterationsMicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer.27893706
Prostate Cancer Pathway, Secondary malignant neoplasm of prostate, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsHere we demonstrate for the first time that a microRNA component of this region-miR-383-is frequently downregulated in prostate cancer, has a critical role in determining tumor-initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells.27893706
Sessile Serrated Adenoma/PolypEpigenetic AlterationsComprehensive DNA Methylation and Mutation Analyses Reveal a Methylation Signature in Colorectal Sessile Serrated Adenomas.27896617
Breast CarcinomaEpigenetic AlterationsLong intergenic non-coding RNA expression signature in human breast cancer.27897201
Primary malignant neoplasmEpigenetic AlterationsEpigenetic markers based on differential methylation of DNA sequences are used in cancer screening and diagnostics.27898666
Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XEpigenetic AlterationsCirculating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes.27899485
Metabolic DiseasesEpigenetic AlterationsMicroRNA-122 (miR-122) is abundant in the liver and involved in lipid homeostasis, but its relevance to the long-term risk of developing metabolic disorders is unknown.27899485
Carotid StenosisEpigenetic AlterationsCirculating MicroRNAs as Novel Biomarkers of Stenosis Progression in Asymptomatic Carotid Stenosis.27899750
Dental PlaqueEpigenetic AlterationsRecent studies suggest a regulatory function for several microRNAs (miRNAs) on the evolution of carotid plaque, but its role in ACAS progression is mostly unknown.27899750
Osteoporotic FracturesEpigenetic AlterationsMiR-148a the epigenetic regulator of bone homeostasis is increased in plasma of osteoporotic postmenopausal women.27900532
Secondary malignant neoplasm of female breastEpigenetic AlterationsUnravelling site-specific breast cancer metastasis: a microRNA expression profiling study.27902972
MetastasisEpigenetic AlterationsMicroRNAs (miRs) are important regulators of many physiological and pathological processes, including metastasis.27902972
Cardiovascular DiseasesEpigenetic AlterationsDNA methylation may mediate effects of air pollution on cardiovascular disease.27903268
ArteriosclerosisEpigenetic AlterationsEpigenetic markers may provide insights into mechanisms underlying environmental factors in complex diseases like atherosclerosis.27903268
artery calcificationEpigenetic AlterationsDNA methylation of CDKN2B may play a potential role in artery calcification.27905995
Colorectal Cancer Pathway, MetastasisEpigenetic AlterationsmicroRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5.27906093
Degenerative polyarthritisEpigenetic AlterationsmicroRNA-140-5p (miR-140) has been shown to be involved in cartilage development and osteoarthritis (OA) pathogenesis.27906093
Malignant neoplasm of urinary bladderEpigenetic AlterationsHere, we illustrate that miR-148a-3p is frequently downregulated in bladder cancer and that its expression may be regulated by DNA methylation.27906180
NeoplasmsEpigenetic AlterationsA series of lncRNAs (long noncoding RNAs) have been reported as candidate biomarkers in a variety of tumors.27906682
MIR29A geneEpigenetic AlterationsIn addition, miRNAs, including hsa-miR-29a, hsa-miR-192, and hsa-miR-144, were upregulated hub nodes in the two regulatory networks.27906902
MIR29A gene, IFNG wt AlleleEpigenetic AlterationsCONCLUSIONS Genes including TAF1 and MAFK, and miRNAs including hsa-miR-29a, hsa-miR-192, and hsa-miR-144 might be potential target genes and important miRNAs for IFG and T2DM.27906902
Clinical Coordinator, Colorectal Cancer Pathway, Malignant NeoplasmsEpigenetic AlterationsMicroRNA-21 (miR-21) expression was quantified by real-time qRT-PCR in peripheral blood and saliva samples obtained from patients diagnosed with colorectal cancer (CRC) of varying degrees of malignancy and healthy volunteers.27910062
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe connection among the biochemical pathways in which they are involved (DNA methylation, epigenetic marks on histones and RNA cap methylation) could explain the concentration changes with PCa and supports, once again, the role of metabolomics in upstream processes.27910903
Malignant Neoplasms, SF3B1 wt Allele, Acute lymphocytic leukemia, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetic changes including aberrant HDAC activity are associated with cancers, including myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL).27911138
Autoimmune state, Rheumatoid Arthritis, Right armEpigenetic AlterationsMicroRNAs (miRs) represent a part of epigenetic control of autoimmunity gaining increasing attention in rheumatoid arthritis (RA).27915033
Right armEpigenetic AlterationsUp-regulation of survivin in smokers suggests its role as effector of the adverse epigenetic control in RA.27915033
Right armEpigenetic AlterationsSince cigarette smoking plays important role in RA pathogenesis and reprograms transcriptional profile of miRNAs, we ask if the onco-protein survivin, a novel biomarker of RA, may provide a link between smoking and miRNA.27915033
Myeloid Leukemia, Chronic, Neoplasms, Leukemia, Myelocytic, AcuteEpigenetic AlterationsMultiple omics analysis revealed aberrant alterations of genomics and epigenetics were significantly associated with CPT1A expression, including up- and down-regulation of oncogenes and tumor suppressor, activation and inhibition of leukemic (AML, CML) and immune activation pathways, hypermethylation enrichments on CpG island and gene promoter regions.27916548
Herpes zoster diseaseEpigenetic AlterationsEvaluation of microRNA Expression in Patients with Herpes Zoster.27918431
Hertz (Hz)Epigenetic AlterationsThe results showed that the serum miRNA expression profiles in 41 HZ patients were different from those of control subjects.27918431
Communicable DiseasesEpigenetic AlterationsIt was proposed that circulating microRNAs (miRNAs) in body fluids could potentially indicate infection.27918431
Herpes zoster diseaseEpigenetic AlterationsHowever, the connection between herpes zoster and circulating miRNAs has not been demonstrated.27918431
Hertz (Hz)Epigenetic AlterationsSpecifically, 18 miRNAs were up-regulated and 126 were down-regulated more than two-fold in HZ patients compared with controls.27918431
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer.27919977
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsDysregulation pattern of microRNA-7 (miR-7) and the clinical significance of its expression in colorectal cancer (CRC) are unresolved.27919977
CoinfectionEpigenetic AlterationsWe demonstrated that endogenous miRNA-200a-3p, whose expression was synergistically induced following co-infection, indirectly regulates CXCL10 expression by targeting suppressor of cytokine signaling-6 (SOCS-6), a well-known regulator of the JAK-STAT signaling pathway.27922126
Complete atrioventricular blockEpigenetic AlterationsHere, we explore the hypothesis that NAs may cause persistent epigenetic changes during prolonged NAs therapy in CHB patients.27922198
ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal AdenocarcinomaEpigenetic AlterationsmiRNA-124 (miR-124) expression was known to be downregulated in patients with pancreatic ductal adenocarcinoma (PDAC).27922430
NeoplasmsEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have recently been shown to play critical roles in regulating neurogenesis and brain tumor progression.27923049
Carcinoma of lungEpigenetic AlterationsSmoking-associated DNA methylation markers predict lung cancer incidence.27924164
Carcinoma of lung, Liquid ChromatographyEpigenetic AlterationsNewly established blood DNA methylation markers that are strongly associated with smoking might open new avenues for lung cancer (LC) screening.27924164
Refractory Cytopenia of ChildhoodEpigenetic AlterationsMicroRNAs (miRNAs) play key roles in the pathogenesis of RCC.27924503
Polyp of large intestineEpigenetic AlterationsThe miRNA landscape of colorectal polyps.27925331
NeoplasmsEpigenetic AlterationsWe compared these miRNA expression profiles in polyps to miRNA expression in microsatellite unstable (MSI) and stable (MSS) tumors.27925331
Admitting diagnosisEpigenetic AlterationsThe major differences in miRNA expression were observed between AD and SSP and AD and HP, with few differences in expression noted for SSP and HP.27925331
NeoplasmsEpigenetic AlterationsMiRNA expression in the SSP and HP tumors almost uniformly go in opposite directions from the MSS tumor miRNA expression and was mixed with MSI tumors.27925331
polyps, AdenomaEpigenetic AlterationsExpression of miRNAs in adenomas and polyps may importantly contribute to these pathways.27925331
polypsEpigenetic AlterationsThere were 70 miRNAs with differential expression by polyp type with a fold change <0.75 or >1.34 after adjusting for multiple comparisons.27925331
Adenocarcinoma of lung (disorder), "Alzheimers Disease Assessment Scale-Cognitive CDISC Version QuestionnaireEpigenetic AlterationsIn this study, we aimed to identify novel drivers that would be epigenetically altered through aberrant methylation in early-stage lung adenocarcinoma (LADC), regardless of the presence or absence of tobacco smoking-induced epigenetic field defects.27926516
Aortic Aneurysm, AbdominalEpigenetic AlterationsLong Noncoding RNA Expression Signatures of Abdominal Aortic Aneurysm Revealed by Microarray.27927271
Carcinogenesis, Neoplastic diseaseEpigenetic AlterationsThe serrated neoplasia pathway of colorectal carcinogenesis is characterized by BRAF mutation and aberrant DNA methylation, which have not been reported on Korean patients.27930579
Esophageal carcinomaEpigenetic AlterationsUp-Regulation of MicroRNA-133a Inhibits the MEK/ERK Signaling Pathway to Promote Cell Apoptosis and Enhance Radio-Sensitivity by Targeting EGFR in Esophageal Cancer In Vivo and In Vitro.27933650
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsEpigenetic aberrations have been identified as biomarkers to predict the risk of Alzheimers disease (AD).27935556
Admitting diagnosisEpigenetic AlterationsThese results suggest that elevation of peripheral BDNF promoter methylation might be used as potential epigenetic biomarkers for predicting the conversion from aMCI to AD.27935556
Secondary malignant neoplasm of liverEpigenetic AlterationsMicroRNA-203 predicts human survival after resection of colorectal liver metastasis.27935861
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsSome microRNAs (miRNAs) become deregulated in cancers and contribute to cancer progression.27935861
NeoplasmsEpigenetic AlterationsWe employed next-generation sequencing of small-RNAs to profile miRNAs in solid tumors obtained from 38 patients who underwent hepatectomy for CRLM.27935861
Celiac DiseaseEpigenetic AlterationsProinflammatory cytokine interferon-g and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease.27936497
Primary malignant neoplasmEpigenetic AlterationsSeveral miRNAs are aberrantly expressed in cancer.27939727
Prostate Cancer PathwayEpigenetic AlterationsPITX2 DNA Methylation as Biomarker for Individualized Risk Assessment of Prostate Cancer in Core Biopsies.27939865
Carcinoma, Ovarian Epithelial, Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNA (lncRNA) has been recognized as a regulator of gene expression, and the dysregulation of lncRNAs is involved in the progression of many types of cancer, including epithelial ovarian cancer (EOC).27941916
Primary malignant neoplasmEpigenetic AlterationsAn integrated approach, combining the detection of ALU fragments and cancer type-specific epigenetic alteration, can improve diagnostic efficiency and better define the prognostic value for CRC disease.27943272
Primary central nervous system lymphomaEpigenetic AlterationsOur data demonstrated that epigenetic alterations in the promoter region downregulated SHP1 expression in PCNSL patients.27959415
Primary central nervous system lymphomaEpigenetic AlterationsTherapeutical regimens with epigenetic modifiers may be a potential option for patients with PCNSL.27959415
Primary malignant neoplasmEpigenetic AlterationsDNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes.27965295
AmeloblastomaEpigenetic AlterationsHowever, ameloblastoma ncRNA expression data is lacking.27965463
Primary malignant neoplasmEpigenetic AlterationsNew evidence suggests that non-coding RNAs (ncRNAs) play a critical role in tumourgenesis and prognosis of cancer.27965463
Parkinsonian DisordersEpigenetic AlterationsMicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian.27965467
SynucleinopathiesEpigenetic AlterationsMicroRNAs (miRNAs) play a key role in the metabolism of a-synuclein but the mechanism involved in synucleinopathy remains unclear.27965467
palladiumEpigenetic AlterationsThe results revealed that 11 microRNAs were differently expressed in CSF, emphatically as miR-144-5p, miR-200a-3p and miR-542-3p, which were dramatically up-regulated in both A53T-transgenic mice and PD patients, and had a helpful accuracy for the PD prediction.27965467
palladiumEpigenetic AlterationsTaken together, our data suggested that miRNAs in CSF, such as miR-144-5p, miR-200a-3p and miR-542-3p, may be useful to the PD diagnosis as potential biomarkers.27965467
Malignant tumor of colonEpigenetic AlterationsWe developed a prognostic 4-microRNA expression signature for colon cancer patient survival, and validated miR-130a sponge could sensitized 5-FU anti-cancer effect.27974852
Malignant tumor of colonEpigenetic AlterationsIn the end, we test the selected miRNAs in HT126 colon cancer cells to validate its anti-cancer effect.27974852
Coronary Artery DiseaseEpigenetic AlterationsCirculating microRNAs (miRNAs) have been proved to serve as biomarkers for diagnosis and assessment of prognosis of coronary artery disease (CAD).27976798
Breast CarcinomaEpigenetic AlterationsPurpose: In breast cancer models, combination epigenetic therapy with a DNA methyltransferase inhibitor and a histone deacetylase inhibitor led to reexpression of genes encoding important therapeutic targets, including the estrogen receptor (ER).27979916
PsoriasisEpigenetic AlterationsEpigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis.27980695
Chronic Lymphocytic LeukemiaEpigenetic AlterationsAlthough genetic studies have identified chromosomal aberrations or specific mutations, epigenetic changes have been poorly characterized in CLL.27980696
Chronic Lymphocytic LeukemiaEpigenetic AlterationsDespite a slight deregulation in CLL cells compared with normal B cells, we identified a significant association between TET/IDH gene expression and prognosis, suggesting that epigenetic changes could potentially be associated with disease progression.27980696
NeoplasmsEpigenetic AlterationsOur study provides evidence of alterations in the expression of apoptosis-regulating miRNAs in salivary gland tumors, suggesting possible involvement of these microRNAs in salivary gland tumorigenesis.27981346
NeoplasmsEpigenetic AlterationsAltered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.27981346
Immune System DiseasesEpigenetic AlterationsMicroRNA-155 is a biomarker of T-cell activation and immune dysfunction in HIV-1-infected patients.27981723
Breast CarcinomaEpigenetic AlterationsEpigenetic change at the CpG islands in the APC promoter was associated with the silence of its transcript and the loss of protein expression suggesting that this event is the main mechanism regulating the APC expression in breast cancer.27983523
Stomach CarcinomaEpigenetic AlterationsPrognostic value of candidate microRNAs in gastric cancer: A validation study.27983528
Stomach CarcinomaEpigenetic AlterationsStudies have reported the prognostic value of dysregulated microRNAs (miRNAs) in gastric cancer (GC).27983528
Prediabetes syndrome, Diabetes MellitusEpigenetic AlterationsGlobal DNA methylation was significantly higher in prediabetes and screen-detected diabetes than in normal glucose tolerance (both p <= 0.033) and in screen-detected diabetes compared to known diabetes on treatment (p = 0.019).27990443
Diabetes MellitusEpigenetic AlterationsThere was no difference in global DNA methylation between known diabetes on treatment and normal glucose tolerance (p > 0.999).27990443
Diabetes MellitusEpigenetic AlterationsThe association of global DNA methylation with screen-detected diabetes but not treated diabetes suggests that glucose control agents to some extent may be reversing DNA methylation.27990443
Diabetic AngiopathiesEpigenetic AlterationsThe association between NOS3 rs1799983 polymorphisms and DNA methylation suggests gene-epigenetic mechanisms through which vascular diabetes complications develop despite adequate metabolic control.27990443
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsFive miRNAs that have been consistently found deregulated in PCa (miR-21, miR-141, miR-214, miR-375, and let-7c) were analyzed in urinary pellets from 60 prostate cancer (PCa) patients and 10 healthy subjects by qRT-PCR.27990656
Admitting diagnosisEpigenetic AlterationsThe results indicated that DNA methylation in the two regions was significantly increased in AD and aMCI as compared to NCs (P < 0.0001, P < 0.0001, ANOVA).27992572
DementiaEpigenetic AlterationsDNA methylation in the COASY promoter region was associated with CDR Scale Sum of Boxes (CDR-SB), an indicator of dementia severity.27992572
Admitting diagnosisEpigenetic AlterationsIn conclusion, DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of AD and aMCI.27992572
Primary malignant neoplasmEpigenetic AlterationsAlthough aberrant DNA methylation in cfDNA has been reported for more than a decade, its diagnostic accuracy remains unsatisfactory for cancer screening.27993161
Breast CarcinomaEpigenetic AlterationsCirculating cell-free DNA-based epigenetic assay can detect early breast cancer.27993161
SHF geneEpigenetic AlterationsThe methylation array analysis identified 12 novel epigenetic markers (JAK3, RASGRF1, CPXM1, SHF, DNM3, CAV2, HOXA10, B3GNT5, ST3GAL6, DACH1, P2RX3, and chr8:23572595) for detecting BC.27993161
Aneurysm, Aortic Aneurysm, AbdominalEpigenetic AlterationsScreening of circulating microRNA biomarkers for prevalence of abdominal aortic aneurysm and aneurysm growth.27993388
Aortic Aneurysm, AbdominalEpigenetic AlterationsMicroRNA (miR) are important regulators of gene expression and biological processes and have recently been suggested as possible biomarkers for abdominal aortic aneurysm (AAA) disease.27993388
NeoplasmsEpigenetic AlterationsThere is accumulating evidence indicating that long non-coding RNA H19 and its mature product miR-675 play essential roles for tumor growth and progression.27994496
sievert, One Vessel Coronary DiseaseEpigenetic AlterationsOn identifying a novel locus associated with SVS, we assessed its influence on other small vessel disease phenotypes, as well as on messenger RNA (mRNA) expression of nearby genes, and on DNA methylation of nearby CpG sites in whole blood and in the fetal brain.27997041
Cholangiocarcinoma, NeoplasmsEpigenetic AlterationsRelative DNA methylation of SHOX2 and SEPT9 was quantified in tumor specimens and matched normal adjacent tissue (NAT) from 71 BTC patients, as well as in plasma samples from an independent prospective cohort of 20 cholangiocarcinoma patients and 100 control patients.27999621
CholangiocarcinomaEpigenetic AlterationsElevated DNA methylation levels were also found in plasma derived from cholangiocarcinoma patients.27999621
Malignant neoplasm of endometriumEpigenetic AlterationsMicro-RNA signature of lymphovascular space involvement in type 1 endometrial cancer.28000202
Degenerative polyarthritisEpigenetic AlterationsMicroRNAs (miRNAs/miR) are a group of endogenous, short, non-coding RNAs, the expression profile of which is disturbed in the cartilage of patients with OA.28000846
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma.28000880
Malignant Neoplasms, Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsIncreasing number of studies demonstrated that microRNAs are dysregulated in a variety of human cancers, and play significant roles in tumorigenesis and tumor development, including glioma.28000880
melanomaEpigenetic AlterationsThe microRNA expression profiles of formalin-fixed, paraffin-embedded melanoma and melanocytic nevi samples were estimated with a microarray and subsequently validated by real-time PCR.28005927
melanomaEpigenetic AlterationsThe microarray revealed that the expression of 1,171 microRNAs was altered in melanoma samples compared to melanocytic nevi.28005927
SepticemiaEpigenetic AlterationsAccumulating evidences have confirmed that miRNAs have important roles in sepsis.28006751
CarcinogenesisEpigenetic AlterationsGlobal DNA methylation, possibly influenced by lifestyle and environmental factors, has been suggested to play an active role in carcinogenesis.28006848
Dermatologic disordersEpigenetic AlterationsDerivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders.28008606
Pituitary AdenomaEpigenetic AlterationsMicroRNA (miR)-26a has been found to be abnormally highly expressed in pituitary adenoma, indicating possible involvement in pathogenesis.28012286
Liver neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA (miRNA) sequencing was performed in 50 liver tumors to identify groups of tumors with similar profiles and differentially expressed miRNAs (DEMs).28012864
NeoplasmsEpigenetic AlterationsmiRNA profiling identified a specific expression profile in DICER1-mutated tumors with a decreased expression of mature miRNAs compared to the other samples.28012864
Leukemia, Myelocytic, AcuteEpigenetic AlterationsInhibition of MicroRNA-149-5p Induces Apoptosis of Acute Myeloid Leukemia Cell Line THP-1 by Targeting Fas Ligand (FASLG).28013316
Admitting diagnosisEpigenetic AlterationsIn monozygotic twins discordant for AD we analysed the expression of selected genes, and their possible regulation by epigenetic mechanisms in peripheral blood mononuclear cells, possibly useful to discover biomarkers.28017215
Ovarian Serous AdenocarcinomaEpigenetic AlterationsCirculating miRNA landscape identifies miR-1246 as promising diagnostic biomarker in high-grade serous ovarian carcinoma: A validation across two independent cohorts.28017893
Metastasis, Liver carcinomaEpigenetic AlterationsMicroRNA-33b suppresses the proliferation and metastasis of hepatocellular carcinoma cells through the inhibition of Sal-like protein 4 expression.28026002
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs or miRs) have been found to participate in the development and malignant progression of human cancers by negatively mediating the expression of their target genes.28026002
Psoriasis, Inflammatory dermatosisEpigenetic AlterationsPsoriasis is a common chronic inflammatory skin disease caused by genetic and epigenetic factors.28028860
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsIdentifying prognostic biomarkers based on aberrant DNA methylation in kidney renal clear cell carcinoma.28029655
Malignant NeoplasmsEpigenetic AlterationsDNA methylation is regarded as a regulator of gene expression in cancers, which may be a molecular marker of prognosis.28029655
Primary malignant neoplasmEpigenetic AlterationsMolecular mechanisms of alterations in protein tyrosine phosphatases (PTPs) genes in cancer have been previously described and include chromosomal aberrations, gene mutations, and epigenetic silencing.28031238
Gastric Mucosa-Associated Lymphoid Tissue Lymphoma, GastritisEpigenetic AlterationsWe analyzed the expression of 384 miRNAs using TaqMan microRNA assay in a training series of 10 gastric MALT lymphomas, 3 chronic gastritis and 2 reactive lymph nodes.28031239
Gastric Mucosa-Associated Lymphoid Tissue LymphomaEpigenetic AlterationsGastric MALT lymphoma is characterized by a specific miRNA expression profile.28031239
Gastric Mucosa-Associated Lymphoid Tissue Lymphoma, GastritisEpigenetic AlterationsMicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis.28031239
Gastric Mucosa-Associated Lymphoid Tissue Lymphoma, Chronic gastritisEpigenetic AlterationsThen, significantly deregulated miRNAs were individually assessed by real-time PCR in a validation series of 16 gastric MALT lymphomas and 12 chronic gastritis.28031239
Gastric Mucosa-Associated Lymphoid Tissue LymphomaEpigenetic AlterationsAmong the differentially expressed miRNAs, a significant overexpression of miR-142-3p and miR-155 and down-regulation of miR-203 was observed in gastric MALT lymphoma when compared to chronic gastritis.28031239
melanomaEpigenetic Alterations5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker detectable through immunohistochemistry (IHC) that has been shown to distinguish benign nevi from melanoma with high sensitivity and specificity.28032662
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsEpigenetic silencing of tumor suppressors contributes to the development and progression of colorectal cancer (CRC).28032859
Clinical CoordinatorEpigenetic AlterationsThis study aimed to clarify its epigenetic alteration, molecular mechanisms and clinical significance in CRC.28032859
Clinical CoordinatorEpigenetic AlterationsIt suggests that methylation status of SPOP promoter can be used as a novel epigenetic biomarker and a therapeutic target in CRC.28032859
Primary malignant neoplasmEpigenetic AlterationsPolymorphisms in pre-miRNAs may affect its expression, then have effect on its target mRNAs and be associated with cancer susceptibility.28034876
ovarian neoplasmEpigenetic AlterationsIntegration of Population-Level Genotype Data with Functional Annotation Reveals Over-Representation of Long Noncoding RNAs at Ovarian Cancer Susceptibility Loci.28035019
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs are small non-coding RNAs that post-transcriptionally regulate many important biological processes and influence cancer phenotypes.28035073
Adenocarcinoma of lung (disorder)Epigenetic AlterationsMicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status.28035073
Malignant Neoplasms, Adenocarcinoma of lung (disorder)Epigenetic AlterationsA total of 72 surgically resected lung adenocarcinoma specimens (19 EGFR-mutated, 17 KRAS-mutated, 16 ALK-rearranged, and 20 triple negative cancers) were screened for 23 microRNAs using quantitative real-time reverse transcriptase polymerase chain reaction.28035073
Vascular Invasion AssessmentEpigenetic AlterationsEight microRNAs were associated with clinicopathological features, such as male sex and ever-smoker status (high miR-373-3p, miR-1343-3p, miR-138-1-3p, and miR-764; low miR-27b-3p) and vascular invasion (high miR-27b-3p; low miR-1343-3p and miR-764).28035073
Injury of kidneyEpigenetic AlterationsThe expression of miR-192, a specific kidney-enriched miRNA, was assessed in both the plasma and kidney of IRI rats at different time points after kidney injury and compared to renal function and kidney histological changes.28035621
Squamous cell carcinoma of esophagusEpigenetic AlterationsA novel serum microRNA signature to screen esophageal squamous cell carcinoma.28035762
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe diagnostic value of the 5-miRNA signature was validated by an external cohort (60 ESCC vs. 60 NCs).28035762
Squamous cell carcinoma of esophagusEpigenetic AlterationsIn conclusion, we identified a 5-miRNA signature in serum for the detection of ESCC.28035762
Squamous cell carcinoma of esophagusEpigenetic AlterationsCirculating microRNAs (miRNAs) have been used as promising diagnostic biomarkers for esophageal squamous cell carcinoma (ESCC).28035762
Squamous cell carcinoma of esophagusEpigenetic AlterationsUsing qRT-PCR, identified serum miRNAs were further confirmed in training (32 ESCC vs. 32 NCs) and testing stages (108 ESCC vs. 96 NCs).28035762
Squamous cell carcinoma of esophagusEpigenetic AlterationsConsequently, five serum miRNAs (miR-20b-5p, miR-28-3p, miR-192-5p, miR-223-3p, and miR-296-5p) were significantly overexpressed in ESCC compared with NCs.28035762
NeoplasmsEpigenetic AlterationsPatients with LINE-1 hypomethylated tumors had a significantly worse overall survival compared to patients with a higher level of LINE-1 tumor DNA methylation (HR 1.68, 95% CI 1.03-2.75; p = 0.04).28035987
liposarcomaEpigenetic AlterationsAssessing the clinical value of microRNAs in formalin-fixed paraffin-embedded liposarcoma tissues: Overexpressed miR-155 is an indicator of poor prognosis.28036291
SpondylitisEpigenetic AlterationsTo determine the microRNA (miR) signature in ankylosing spondylitis (AS) T helper (Th)17 cells.28039186
Leukemia, Myelocytic, AcuteEpigenetic Alterations5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia.28039446
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsDNA methylation may epigenetically inactivate tumor suppressor genes in NSCLC.28039450
Nerve DegenerationEpigenetic AlterationsRecent studies suggest that environmental factors may contribute for neurodegeneration through induction of epigenetic modifications, such as DNA methylation, that is carried out by enzymes, such as DNMT1 and DNMT3B.28041964
ovarian neoplasm, RAB27A geneEpigenetic AlterationsMicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.28043921
NeoplasmsEpigenetic AlterationsThe cluster of microRNAs (miRNAs) in the DLK1-DIO3 genomic imprinted region contains several miRNAs that have a significant regulatory role in tumor proliferation and invasion.28043921
ovarian neoplasmEpigenetic AlterationsOne of these miRNAs is miR-134-3p, and its expression changes significantly in human ovarian cancer stem cells (OCSCs) and in CD44-/CD133- ovarian cancer.28043921
Vascular Invasion AssessmentEpigenetic AlterationsSerum miRNA-10b-3p was upregulated in the presence of macrovascular invasion (MVI), and those with higher serum miRNA-10b-3p had significantly shorter survival during treatment (P = 0.042).28049231
Hollings Cancer CenterEpigenetic AlterationsAll of the miRNAs except miR-21 were found to be upregulated in serum samples from HCC patients.28049231
Hollings Cancer CenterEpigenetic AlterationsNone of the miRNAs assayed differed significantly in terms of expression between the responder and non-responder groups among HCC patients.28049231
Adenocarcinoma Of EsophagusEpigenetic AlterationsEpigenetic regulation on the gene expression signature in esophagus adenocarcinoma.28049580
Diabetes MellitusEpigenetic AlterationsThe Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of Uyghur in XinJiang in Type 2 Diabetes.28050569
Heart failure, Acute myocardial infarctionEpigenetic AlterationsCirculating MicroRNA-145 is Associated with Acute Myocardial Infarction and Heart Failure.28051023
Clinical CoordinatorEpigenetic AlterationsWe measured WNT5A mRNA level using qRT-PCR and DNA methylation using methylation-specific PCR (MSP) in HCT116, HT29, SW620, HCT8, LoVo, SW480, and Rko CRC cells.28051879
Pancreatic carcinomaEpigenetic AlterationsThe role of microRNA in the aberrant autophagy that occurs in pancreatic cancer remains controversial.28052003
Hypoxia, Pancreatic carcinomaEpigenetic AlterationsBecause hypoxia is known to induce autophagy, we screened for differentially expressed microRNAs using a miRNA microarray with pancreatic cancer cells cultured under normoxic and hypoxic conditions.28052003
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsCurrent knowledge about the role of epigenetics in type 2 diabetes (T2D) remains limited.28052964
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusEpigenetic AlterationsOur study provides a comprehensive picture of the islet DNA methylome in individuals with and without diabetes and highlights the importance of epigenetic dysregulation in pancreatic islets and T2D pathogenesis.28052964
Alzheimers DiseaseEpigenetic AlterationsDNA Methylation Profiles of Selected Pro-Inflammatory Cytokines in Alzheimer Disease.28053004
Degenerative disorderEpigenetic AlterationsIL-1b and IL-6 genes are modulated by DNA methylation in different chronic and degenerative diseases; it is also well known that LOAD may have an epigenetic basis.28053004
Loading Technique, Neurogenic InflammationEpigenetic AlterationsOur analysis provides evidence that neuroinflammation in LOAD is associated with (and possibly mediated by) epigenetic modifications.28053004
SymptomsEpigenetic AlterationsThe finding suggests that on exposure with urban environment, risk allele carriers tend to develop asthma symptoms via epigenetic regulation of motif associated with maturation of B-lymphocytes.28055272
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCirculating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer.28055956
Adenocarcinoma of lung (disorder)Epigenetic AlterationsUsing a quantitative polymerase chain reaction (qPCR) array panel, we analyzed 84 plasma exosomal miRNAs in 10 lung adenocarcinoma patients and 10 matched healthy controls.28055956
Non-Small Cell Lung CarcinomaEpigenetic AlterationsNine candidate miRNAs were selected based on differential expression and previous reports for further evaluating their prognostic roles in 196 NSCLC patients.28055956
Chronic Obstructive Airway DiseaseEpigenetic AlterationsmiRNA and mRNA profiling of PBMCs from pooled 17 smokers and 14 COPD subjects was detected by high-throughput microarray.28057018
Chronic Obstructive Airway DiseaseEpigenetic AlterationsThe expression of miRNA and mRNA were dysregulated in PBMCs of COPD patients compared with smokers without airflow limitation.28057018
Chronic Obstructive Airway DiseaseEpigenetic AlterationsThe regulation network between the dysregulated miRNA and mRNA may provide potential therapeutic targets for COPD.28057018
Restenosis, Diabetes MellitusEpigenetic AlterationsSerum miRNA-143 expression in the restenosis group was correlated with smoking status, history of diabetes, BSL, and LDL-C (all P < 0.05).28057086
Clinical CoordinatorEpigenetic AlterationsSeveral age-related DNA methylation alterations can be observed during CRC development and progression affecting the mRNA expression of certain CRC- and adenoma-related key control genes.28058013
Cachexia, Skeletal muscle structureEpigenetic AlterationsSmall RNAome profiling from human skeletal muscle: novel miRNAs and their targets associated with cancer cachexia.28058815
Gallbladder CarcinomaEpigenetic AlterationsMicroRNA-29c-5p suppresses gallbladder carcinoma progression by directly targeting CPEB4 and inhibiting the MAPK pathway.28060377
Primary malignant neoplasmEpigenetic AlterationsIncreasing evidence has highlighted the critical roles of long non-coding RNA (lncRNA) in cancer development and progression.28060759
Papillary renal cell carcinoma type 2, Renal Cell Carcinoma Pathway, Conventional (Clear Cell) Renal Cell Carcinoma, Kidney Diseases, Papillary Renal Cell Carcinoma, Refractory Cytopenia of ChildhoodEpigenetic AlterationsAn increasing body of evidence supports a key role for Keap1/Nrf2 pathway in kidney diseases and renal cell carcinoma (RCC), but data concerning the molecular basis and the clinical effect of its deregulation remain incomplete.Here we present a molecular profiling of the KEAP1 and NFE2L2 genes in five different Renal Cell Carcinoma histotypes by analysing 89 tumor/normal paired tissues (clear cell Renal Carcinoma, ccRCCs; Oncocytomas; Papillary Renal Cell Carcinoma Type 1, PRCC1; Papillary Renal Cell Carcinoma Type 2, PRCC2; and Chromophobe Cell Carcinoma).A tumor-specific DNA methylation of the KEAP1 gene promoter region was found as a specific feature of the ccRCC subtype (18/37, 48.6%) and a direct correlation with mRNA levels was confirmed by in vitro 5-azacytidine treatment.28061437
Renal Cell Carcinoma PathwayEpigenetic AlterationsAnalysis of an independent data set of 481 ccRCC and 265 PRCC tumors corroborates our results and multivariate analysis reveals a significant correlation among ccRCCs epigenetic KEAP1 silencing and staging, grading and overall survival.Our molecular results show for the the first time the epigenetic silencing of KEAP1 promoter as the leading mechanism for modulation of KEAP1 expression in ccRCCs and corroborate the driver role of Keap1/Nrf2 axis deregulation with potential new function as independent epigenetic prognostic marker in renal cell carcinoma.28061437
NeoplasmsEpigenetic AlterationsGenetic variants in the TGFb-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue.28061442
Carcinoma, Colorectal CarcinomaEpigenetic AlterationsEvaluation of the differential expression between carcinoma and normal mucosa showed that SMAD3 rs12708491 and rs2414937, NFkB1 rs230510 and rs3821958, and RUNX3 rs6672420 were associated with several miRNAs for colorectal carcinoma.28061442
Acute myocardial infarctionEpigenetic AlterationsThe increased proangiogenic activity of these cells in patients with STEMI and the observation that in particular miR-378 regulates the angiogenic capacity of CD34+ progenitor cells in vivo suggest that this unique miRNA expression pattern represents a novel endogenous repair mechanism activated in acute myocardial infarction.28062497
Degenerative polyarthritisEpigenetic AlterationsExpression of miRNA-140 in Chondrocytes and Synovial Fluid of Knee Joints in Patients with Osteoarthritis.28065216
Degenerative polyarthritisEpigenetic AlterationsResults The expression of miRNA-140 in chondrocytes of knees in OA patients was reduced than that in normal knees, and the between-group difference was statistically significant (F=305.464, P<0.001).28065216
Degenerative polyarthritisEpigenetic AlterationsConclusion miRNA-140 could be detected in chondrocytes and synovial fluid of OA patients, and its expression was negatively correlated with the severity of OA.28065216
Stomach Carcinoma, Helicobacter pyloriEpigenetic AlterationsThese findings suggested that the polymorphisms in these miRNAs might be biomarkers for gastric cancer risk and prognosis, especially for populations infected with Helicobacter pylori or who consume alcohol.28067243
NeoplasmsEpigenetic AlterationsRegarding DNA methylation, all four SMARCB1/INI1-deficient tumors showed methylation of RASSF1 gene by means of MS-MLPA.28069272
Myeloid Leukemia, ChronicEpigenetic AlterationsLong noncoding RNA HULC promotes cell proliferation by regulating PI3K/AKT signaling pathway in chronic myeloid leukemia.28069548
CarcinogenesisEpigenetic AlterationsThese data suggest that disruption of the differentiated state of precancerous cells via alterations of expression, independent of differences in organs and/or carcinogenetic factors, may be a common feature of DNA methylation alterations during carcinogenesis in multiple organs.28069692
Depressive disorder, Depression, CTCAEEpigenetic AlterationsNo significant interrelation was noticed between the number of depression episodes, the severity of depressive disorders and the expression of miRNA selected.28073061
Depressive disorder, Depression, CTCAEEpigenetic AlterationsThere is no significant difference in miRNAs expression between patients with recurrent depressive disorders and those in the first episode of depression.28073061
Malignant Neoplasms, Leukemia, Myelocytic, AcuteEpigenetic AlterationsGenetic changes are infrequent in acute myeloid leukemia (AML) compared with other malignancies and often involve epigenetic regulators, suggesting that an altered epigenome may underlie AML biology and outcomes.28074068
Adenocarcinoma Of EsophagusEpigenetic AlterationsAmong 231 esophageal adenocarcinoma patients of all stages/treatment plans, 38 candidate genetic polymorphisms (17 biogenesis, 9 miRNA targets, 5 pri-miRNA, 7 pre-miRNA) were genotyped and analyzed.28074552
Bacterial peritonitis, AscitesEpigenetic AlterationsMicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis.28074870
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsThe aberrant expressions of long noncoding RNAs have been reported in numerous cancers, which have facilitated the cancer diagnosis.28076325
Arthritis, ReactiveEpigenetic AlterationsMicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis.28076897
Communicable DiseasesEpigenetic AlterationsTo provide insights into underlying pathogenic processes associated with antibiotic-refractory LA (postinfectious LA), we analyzed differences in microRNA (miRNA) expression between LA patients with active infection and those with postinfectious LA.28076897
ArthritisEpigenetic AlterationsSF from postantibiotic LA patients also exhibited marked inflammatory (miR-146a, miR-155), wound repair (miR-142), and proliferative (miR-17-92) miRNA signatures, and higher levels of these miRNAs correlated with longer arthritis duration.28076897
Malignant Neoplasms, Stomach Carcinoma, MetastasisEpigenetic AlterationsRecently, non-coding RNAs have been recognized to promote metastasis in various cancers, including gastric cancer.28077118
Chronic Kidney Diseases, Fibrosis AssessmentEpigenetic AlterationsThus, miRNA are associated with kidney fibrosis, and specific urinary and plasma miRNA profile may have diagnostic and prognostic utility in CKD.28077372
GerminomaEpigenetic AlterationsWe showed that pure germinomas are characterized by global low DNA methylation, a unique epigenetic feature making them distinct from all other iGCTs subtypes.28078450
Liver carcinomaEpigenetic AlterationsSerum microRNA panel for early diagnosis of the onset of hepatocellular carcinoma.28079796
Hollings Cancer CenterEpigenetic AlterationsIn addition, the combination of 3-miRNA panel and AFP was even more effective for discriminating the early stage HCC patients (AUC = 0.988) and low-level AFP HCC patients (AUC = 0.989) from control.28079796
Primary malignant neoplasmEpigenetic AlterationsUnique change of circulating microRNAs (miRNAs) was recognized to occur in early oncogenesis, which conferred it the potential as biomarkers for early detection of cancer.28079796
Hollings Cancer CenterEpigenetic AlterationsThe selected differentially expressed miRNAs were further verified in 115 HCC patients and 40 health controls by qRT-PCR.28079796
Ulcerative ColitisEpigenetic AlterationsThis panel of miRNAs promoter methylation accurately detects UC in urine, comparing well with other promising epigenetic-based biomarkers.28081549
Carcinoma, Transitional CellEpigenetic AlterationsMicroRNA promoter methylation: a new tool for accurate detection of urothelial carcinoma.28081549
Ulcerative ColitisEpigenetic AlterationsPromoter methylation levels of both microRNAs were significantly higher in UC tissue samples compared with normal urothelium.28081549
palladiumEpigenetic AlterationsNone of the annotated autosomal genes show changes in DNA methylation between PD individuals and healthy individuals.28081695
Glioblastoma Multiforme PathwayEpigenetic AlterationsInhibition of Beclin-1-Mediated Autophagy by MicroRNA-17-5p Enhanced the Radiosensitivity of Glioma Cells.28081732
Radiation-Induced Cancer, NeoplasmsEpigenetic AlterationsIn nude mice, miRNA-17-5p upregulation sensitized the xenograft tumor to irradiation and suppressed irradiation-induced autophagy.28081732
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe role of miRNAs in the radiosensitivity of glioma cells and the underlying mechanism is still far from clear.28081732
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-92a Promotes Cell Proliferation in Cervical Cancer via Inhibiting p21 Expression and Promoting Cell Cycle Progression.28081742
Malignant Neoplasms, cervical cancerEpigenetic AlterationsMicroRNA-92a (miR-92a) generally plays a promoting role in human cancers, but the underlying mechanism in cervical cancer remains unclear.28081742
Malignant Neoplasms, GliomaEpigenetic AlterationsAbnormal expression of the long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is oncogenic in several human cancers, including gliomas.28083786
Primary malignant neoplasmEpigenetic AlterationsHeterogeneous patterns of DNA methylation-based field effects in histologically normal prostate tissue from cancer patients.28084441
Non-MalignantEpigenetic AlterationsOur results suggest that a novel four-gene signature may be used to increase sensitivity for PC diagnosis through detection of epigenetic field effects in histologically non-malignant prostate tissue samples.28084441
SF3B1 wt Allele, Leukemia, Myelocytic, AcuteEpigenetic AlterationsSince small non-coding RNAs (sRNAs), including microRNA (miRNAs), act as regulators of cellular differentiation, we hypothesized that changes to sRNAs might be implicated in the progression of MDS to AML.28084850
Bone MarrowEpigenetic AlterationsWe identified five miRNAs that differentiated Groups A and B, independent of bone marrow blast percentage, including three members of the miR-181 family, as well as differential patterns of miRNA isoforms (isomiRs) and tDRs.28084850
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia.28084850
Malignant NeoplasmsEpigenetic AlterationsSRA1, a long non-coding RNA (lncRNA), serves as a critical regulator in several cancers.28085012
Papillary thyroid carcinomaEpigenetic AlterationsExpressions of miRNAs in papillary thyroid carcinoma and their associations with the clinical characteristics of PTC.28085013
Degenerative polyarthritisEpigenetic AlterationsMicroRNAs (miRNAs) play an important role in cartilage homeostasis, mechanotransduction, and in the pathogenesis of osteoarthritis (OA).28085114
Degenerative polyarthritisEpigenetic AlterationsIn conclusion, in OA chondrocytes, HP restores the expression levels of some miRNAs, downregulates MMP-13, ADAMTS-5, and HDAC-4, and modulates the Wnt/b-catenin pathway activation.28085114
DifferentEpigenetic AlterationsWe identified 36 CpG sites with differential loss of DNA methylation and 8 CpG sites with differential gain of DNA methylation, representing 25 genes and 7 genes, respectively.28085900
Lupus Erythematosus, SystemicEpigenetic AlterationsMoreover, we showed that the DNA methylation signatures of SLE can be defined in unfractionated white blood cells.28085900
Lupus Erythematosus, SystemicEpigenetic AlterationsOur epigenetic findings further support the importance of the type I interferon pathway in SLE pathogenesis.28085900
Clinical CoordinatorEpigenetic AlterationsRecently, mechanisms involving noncoding RNAs have been implicated in the development of CRC.28086904
Clinical Coordinator, Malignant tumor of colonEpigenetic AlterationsDNA methylation status can be considered as a useful predictor of survival after CRC surgery, particularly for patients with stage I/II disease or colon cancer.28087988
Interstitial tissue of prostateEpigenetic AlterationsmicroRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma.28089917
MyelodysplasiaEpigenetic AlterationsMutations in genes related to DNA methylation and splicing machinery were found in T-cell samples, which expand at the initial diagnosis of the myelodysplasia, suggesting their importance as early disease events.28090092
Prostate Cancer PathwayEpigenetic AlterationsChanges in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer.28091918
MicroRNA 19BEpigenetic AlterationsThe miRNA pair hsa-miR-19b-3p and hsa-miR-297 demonstrated highest sensitivity and specificity.28091918
Glioblastoma Multiforme PathwayEpigenetic AlterationsExpression and prognostic value of microRNAs in lower-grade glioma depends on IDH1/2 status.28091987
Intestinal NeoplasmsEpigenetic AlterationsThese findings indicate that the miRNA cluster including miR-194 and miR-215 plays important roles in suppressing the growth and attenuating the stemness of intestinal tumor organoids.28092415
Intestinal NeoplasmsEpigenetic AlterationsCluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids.28092415
Intestinal NeoplasmsEpigenetic AlterationsThe results of microarray analyses revealed that expression of the cluster miRNAs, miR-194 and miR-215 was markedly suppressed in intestinal tumor organoids in comparison with organoids derived from normal intestinal epithelia.28092415
Chronic Lymphocytic LeukemiaEpigenetic AlterationsHere, we valued the expression of ET-1 in CLL, in relation to DNA methylation but also in response to stimulation of some important pathways for the dialogue between CLL and microenvironment.28092772
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe expression of endothelin-1 in chronic lymphocytic leukemia is controlled by epigenetic mechanisms and extracellular stimuli.28092772
Sjogrens SyndromeEpigenetic AlterationsCell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjogrens syndrome.28093418
Sjogrens Syndrome", Perceived stress scaleEpigenetic AlterationsThe aetiology of primary Sjogrens syndrome (pSS), also referred to as autoimmune epithelitis, is incompletely understood but includes an epigenetic contribution.28093418
Colorectal Cancer PathwayEpigenetic AlterationsGenetic and Epigenetic Intra-tumour Heterogeneity in Colorectal Cancer.28097409
NeoplasmsEpigenetic AlterationsPatients with resected CRC had DNA extracted from eight defined tumour areas which were analysed for two genetic mutations (BRAF and KRAS) and one epigenetic trait (CpG island methylator phenotype/CIMP).28097409
Clinical CoordinatorEpigenetic AlterationsIntra-tumoural heterogeneity for both genetic and epigenetic factors in CRC is more prevalent than previously thought in Stage II and Stage III CRC.28097409
Clinical CoordinatorEpigenetic AlterationsThis study provides new insight into epigenetic heterogeneity of CRC and supports the development of a more targeted biopsy strategy to support expansion of personalised treatment.28097409
Stomach Carcinoma, MetastasisEpigenetic AlterationsMicroRNA-187 promotes growth and metastasis of gastric cancer by inhibiting FOXA2.28098868
Stomach CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) play an active role in the pathogenesis of gastric cancer.28098868
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-133b is regulated by TAp63 while no gene mutation is present in colorectal cancer.28098895
Clinical CoordinatorEpigenetic AlterationsWhile the presence of miRNA mutations have frequently been described in CRC, most CRCs do not show any variation in the miR-133b coding sequence.28098895
Malignant NeoplasmsEpigenetic AlterationsmiRNAs have been reported to be involved in multiple cellular processes and the tumorigenesis of various cancers.28098906
Breast CarcinomaEpigenetic AlterationsIn vivo and in vitro effects of microRNA-27a on proliferation, migration and invasion of breast cancer cells through targeting of SFRP1 gene via Wnt/b-catenin signaling pathway.28099945
Liver carcinomaEpigenetic AlterationsHigh expression of micro RNA-135A in hepatocellular carcinoma is associated with recurrence within 12 months after resection.28100188
Hollings Cancer CenterEpigenetic AlterationsIf tissue quality permitted, micro RNAs were measured in HCC and liver tissue.28100188
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDNMT3A is a recurrently mutated epigenetic modifier gene in AML.28100593
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small non-coding RNAs composed of 18-25 nucleotides that can post-transcriptionally regulate gene expression and have key regulatory roles in cancer, acting as both oncogenes and tumor suppressors.28101798
Breast CarcinomaEpigenetic AlterationsThese two miRNAs, miR-10b and miR-153 were significantly associated to lymph node metastases occurrence in triple negative breast carcinoma.28101798
Bicuspid aortic valveEpigenetic AlterationsPatients with bicuspid and tricuspid aortic valve exhibit distinct regional microrna signatures in mildly dilated ascending aorta.28102444
Bicuspid aortic valveEpigenetic AlterationsWe focused on microRNAs as potential contributors to the pathogenesis of ascending aorta (AA) dilatation in patients with stenotic tricuspid (TAV) or bicuspid aortic valve (BAV).28102444
Cardiovascular DiseasesEpigenetic AlterationsAortic RNA was analyzed through PCR arrays, profiling the expression of 84 microRNAs involved in cardiovascular disease.28102444
Cerebral ConvexityEpigenetic AlterationsDistinct signatures of differentially expressed microRNAs are evident in TAV and BAV patients vs. donors, as well as differences between aortic concavity and convexity in patients only.28102444
Takayasu ArteritisEpigenetic AlterationsMicroRNAs could play distinct roles in BAV and TAV aortopathy, with possible implications in diagnosis and therapy.28102444
Nasopharyngeal carcinoma, MetastasisEpigenetic AlterationsMicroRNA-101 inhibits invasion and angiogenesis through targeting ITGA3 and its systemic delivery inhibits lung metastasis in nasopharyngeal carcinoma.28102841
MetastasisEpigenetic AlterationsOur study elucidates the molecular mechanisms of miR-101/ITGA3 pathway in regulating NPC metastasis and angiogenesis, and the systemic delivery of miR-101 provides a potent evidence for the development of a novel microRNA-targeting anticancer strategy for NPC patients.28102841
Lung Diseases, Interstitial, Rheumatoid ArthritisEpigenetic AlterationsPlasma miRNA expression profiles in rheumatoid arthritis associated interstitial lung disease.28103855
Right armEpigenetic AlterationsSixteen selected miRNA levels were analyzed in individual plasmas from 64 RA patients with or without RA-ILD.28103855
Lung Diseases, Interstitial, Right armEpigenetic AlterationsThe values of miRNA index (214, 7) generated from hsa-miR-214-5p and hsa-miR-7-5p for ILD were significantly elevated in RA patients with RA-ILD compared with those without (0.122 +- 0.332 in RA with ILD, 0.006 +- 0.013 in RA without ILD, P = 0.0010).28103855
Stomach NeoplasmsEpigenetic AlterationsEpigenetic regulation of Wnt/b-catenin signal-associated genes in gastric neoplasia of the fundic gland (chief cell-predominant) type.28105693
Malignant Neoplasms, CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) are small, non-coding RNAs that play important roles in the carcinogenesis and progression of cancers.28106539
NeoplasmsEpigenetic AlterationsAberrant expression of miRNAs in tissue and plasma has been found in various solid tumors.28106539
Primary malignant neoplasmEpigenetic AlterationsWe explored the use of a novel RNA-interference method for a driver oncogene regulating cancer specific energy metabolism by the combination treatment with a small interfering RNA (siRNA) and a microRNA.28106737
Malignant Neoplasms, Carcinogenesis, Malignant neoplasm of urinary bladderEpigenetic AlterationsmiRNAs play a key role in the carcinogenesis of many cancers, including bladder cancer.28109084
Adenocarcinoma of lung (disorder)Epigenetic AlterationsLong intergenic non-coding RNA 00152 promotes lung adenocarcinoma proliferation via interacting with EZH2 and repressing IL24 expression.28109288
Primary malignant neoplasmEpigenetic AlterationsNumerous studies have shown that long non-coding RNAs (lncRNAs) behave as a novel class of transcript during multiple cancer processes, such as cell proliferation, apoptosis, migration, and invasion.28109288
Cerebrovascular accidentEpigenetic AlterationsThe Diagnostic Value of Serum miRNA-221-3p, miRNA-382-5p, and miRNA-4271 in Ischemic Stroke.28111007
Cerebrovascular accident, Ischemic strokeEpigenetic AlterationsCirculating serum miRNA-221-3p and miRNA-382-5p levels were significantly lower in patients with ischemic stroke compared to healthy control subjects, whereas there was no significant difference in the serum levels of miRNA-4271 between the stroke patients and healthy controls (P > .05).28111007
Ischemic strokeEpigenetic AlterationsROC curves revealed the areas under the curve for circulating miRNA-221-3p, miRNA-382-5p, and miRNA-4271 to be .8106, .7483, and .6317 in ischemic stroke patients compared with healthy volunteers, respectively.28111007
Ischemic strokeEpigenetic AlterationsOur findings suggest that serum circulating miRNA-221-3p and miRNA-382-5p might be used as potential noninvasive biomarkers for the diagnosis of ischemic stroke.28111007
ArteriosclerosisEpigenetic AlterationsEpigenetic modulation by histone acetyltransferase (HAT) plays a critical role in osteogenic transdifferentiation and atherosclerosis.28111052
Carcinoma, Lobular, Ductal CarcinomaEpigenetic AlterationsExpression of DNA methylation-related proteins in invasive lobular carcinoma of breast: comparison to invasive ductal carcinoma.28111737
cervical cancerEpigenetic AlterationsMicroRNA-145 inhibits tumorigenesis and invasion of cervical cancer stem cells.28112371
Stomach CarcinomaEpigenetic AlterationsMicroRNA-200c binding to FN1 suppresses the proliferation, migration and invasion of gastric cancer cells.28113080
Adenocarcinoma, NeoplasmsEpigenetic AlterationsPreoperative radiological findings, serum CEA level, serum microRNA-183 (miR-183) level, and tumour size differed significantly between patients with adenocarcinoma in situ (AIS) or minimally invasive adenocarcinoma (MIA) and those with invasive adenocarcinoma (IAC).28115792
Malignant Neoplasms, Urinary Bladder, Stomach CarcinomaEpigenetic AlterationsGlobal measures of peripheral blood DNA methylation have been associated with risk of some malignancies, including breast, bladder, and gastric cancer.28116812
Prostate Cancer PathwayEpigenetic AlterationsWe used conditional logistic regression to test for associations between genome-wide measures of DNA methylation and risk of prostate cancer and its subtypes, and by time between blood draw and diagnosis.28116812
Prostate Cancer Pathway, Aggressive behaviorEpigenetic AlterationsWe observed no associations between the genome-wide measure of DNA methylation based on all CpG sites and risk of prostate cancer or aggressive disease.28116812
Craniocerebral Trauma, Amnesia, CTCAE, Post-Concussion SyndromeEpigenetic AlterationsTwo micro-RNAs, mir142-3p and mir423-3p demonstrated potential clinical utility differentiating patients after mild head injury into those at greater risk of developing amnesia and therefore, post-concussive syndromes.28117263
Cardiovascular Diseases, Atrial FibrillationEpigenetic AlterationsMicroRNAs (miRNAs) are emerging as key regulators of complex biological processes in several cardiovascular diseases, including atrial fibrillation (AF).28117343
NeoplasmsEpigenetic AlterationsLong non-coding RNAs (lncRNAs) are emerging as key regulators in tumor development.28119088
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsRecent evidence has highlighted the key regulatory roles of long non-coding RNAs (lncRNAs) in tumor development and progression including gastric cancer (GC).The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been identified as an oncogene in some tumors.28122299
Stomach CarcinomaEpigenetic AlterationsThe long noncoding RNA PVT1 functions as a competing endogenous RNA by sponging miR-186 in gastric cancer.28122299
Penis carcinomaEpigenetic AlterationsIntegrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact.28122331
Epstein-Barr virus associated gastric carcinomaEpigenetic AlterationsHigh level of viral microRNA-BART20-5p expression is associated with worse survival of patients with Epstein-Barr virus-associated gastric cancer.28122341
NeoplasmsEpigenetic AlterationsThe expression of all three analyzed EBV microRNAs was significantly higher in the tumor tissue than in the paired normal tissue (P < 0.001 for each).28122341
GliomaEpigenetic AlterationsEpigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome.28122345
Diabetic RetinopathyEpigenetic AlterationsEffects of miRNA-200b on the development of diabetic retinopathy by targeting VEGFA gene.28122882
Obesity, Complication AspectsEpigenetic AlterationsDNA methylation plays an important role in obesity and related metabolic complications.28123940
ObesityEpigenetic AlterationsTaken together, our data show distinct tissue specific epigenetic alterations which associate with obesity.28123940
Stomach CarcinomaEpigenetic AlterationsClinical significance of the long noncoding RNA RP11-19P22.6-001 in gastric cancer.28128738
Stomach CarcinomaEpigenetic AlterationsTo explore the diagnostic value of the long noncoding RNA RP11-19P22.6-001 in gastric cancer.28128738
Carcinogenesis, Stomach CarcinomaEpigenetic AlterationsLong non-coding RNAs (lncRNAs) play roles in carcinogenesis; however, the significance of most lncRNAs in gastric cancer is unclear.28128738
Stomach CarcinomaEpigenetic AlterationsMicroRNA-21 contributes to the discrimination of chemoresistance in metastatic gastric cancer.28128744
Malignant neoplasm of endometriumEpigenetic AlterationsAberrant MicroRNA Expression in Patients With Endometrial Cancer.28129244
Stomach CarcinomaEpigenetic AlterationsEpigenetic alterations of gastrokine 1 gene expression in gastric cancer.28129645
Stomach Carcinoma, Stomach NeoplasmsEpigenetic AlterationsGKN1 down-regulation in gastric cancer tissues was shown to be associated with high levels of H3K9triMe and with the recruitment of SUV39H1 to the GKN1 promoter, suggesting the presence of an epigenetic transcriptional complex that negatively regulates GKN1 expression in gastric tumors.28129645
Gastrointestinal Stromal TumorsEpigenetic AlterationsGene expression from whole transcriptome sequencing (WTS) and miRNA profiling were performed using fresh-frozen, quadruple WT GIST tissue specimens and compared with SDH and KIT/PDGFRA-mutant GIST.28130400
Gastrointestinal Stromal TumorsEpigenetic AlterationsA total of 247 mRNA transcripts and 66 miRNAs were differentially expressed specifically in quadruple WT GIST.28130400
MYELODYSPLASTIC SYNDROMEEpigenetic AlterationsMechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes.28130497
Colorectal NeoplasmsEpigenetic AlterationsAlthough, initial YAP activation, which stimulates IL6ST gene transcription, may be caused by reduced serine phosphorylation, sustained YAP activation depends on tyrosine phosphorylation by SFKs, whose inhibition, along with STAT3-activating JAK kinases, causes regression of established colorectal tumors.28130546
MeningiomaEpigenetic AlterationsGlobal epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma.28130639
Medial collateral ligamentEpigenetic AlterationsWe suggest that, in the absence of the typical CCND1/IGH@ fusion, this rearrangement promotes MCL pathogenesis by eliminating miRNA interaction elements within the 3-UTR of the CCND1 mRNA transcript consequently resulting in CCND1 overexpression.28132860
Malignant NeoplasmsEpigenetic AlterationsEpigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers.28135856
Malignant NeoplasmsEpigenetic AlterationsBackground: MicroRNAs (miRNAs) mediate negative regulation of target genes through base pairing, and aberrant miRNA expression has been described in cancers.28138309
Colorectal Cancer PathwayEpigenetic AlterationsWe hypothesized that single nucleotide polymorphisms (SNPs) within miRNA target sites might influence clinical outcomes in patients with colorectal cancer.28138309
Colorectal Cancer PathwayEpigenetic AlterationsConclusion: Our results suggest that the genetic interaction profiles among SNPs within miRNA target sites might be prognostic markers for colorectal cancer survival.28138309
Degenerative polyarthritisEpigenetic AlterationsIn conclusion, our findings reveal an miRNA functional pathway important for OA development.28139355
Degenerative polyarthritisEpigenetic AlterationsMicroRNAs (miRNAs) are emerging as important regulators in osteoarthritis (OA) pathogenesis.28139355
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsPCa diagnosis and prognostication might be perfected using epigenetic biomarkers, among which aberrant DNA methylation of microRNA promoters has not been systematically explored.28143614
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsHerein, we identified aberrantly methylated microRNAs promoters in PCa and assessed its diagnostic and prognostic biomarker potential.28143614
Primary malignant neoplasmEpigenetic AlterationsStudies suggest that miRNAs play an important role in cancer; however, their role in HPV-mediated oncogenesis remains largely unknown.28143871
NeoplasmsEpigenetic AlterationsIntegrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC.28146432
Myocardial dysfunction, SepticemiaEpigenetic AlterationsMicroRNA-135a is up-regulated and aggravates myocardial depression in sepsis via regulating p38 MAPK/NF-kB pathway.28147298
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-135a (miR-135a) is implicated in the pathological processes of several cancers.28147298
Lymphoma, Large-Cell, FollicularEpigenetic AlterationsOur data demonstrated that the expression of miRNA-155 was upregulated in newly diagnosed B-cell NHL patients.28148469
Diffuse Large B-Cell Lymphoma, Lymphoma, Large-Cell, FollicularEpigenetic AlterationsDespite contradicting literature reports, the current findings suggest the potential value of miRNA-155 as a biomarker of prognosis and monitoring in B-cell NHL, and especially that of the DLBCL type.28148469
Pancreatic Neoplasm, SpecimenType - Cyst, DysplasiaEpigenetic AlterationsPredicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers.28148542
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsmicroRNA-577 suppresses tumor growth and enhances chemosensitivity in colorectal cancer.28150434
Stenosis, Pulmonary VeinEpigenetic AlterationsThe lack of concordance in twins suggests epigenetic or environmental factors may play a role in the development of pulmonary vein stenosis.28152279
Malignant neoplasm of breastEpigenetic AlterationsA reduced expression of Bin1 caused by DNA methylation, has been reported in breast and prostate cancers.28152502
Malignant neoplasm of larynxEpigenetic AlterationsEvaluation of polymorphisms in microRNA biosynthesis genes and risk of laryngeal cancer in the Polish population.28155978
Primary malignant neoplasmEpigenetic AlterationsThe role of micro RNAs in cancer development is also considerable.28155978
Heart failureEpigenetic AlterationsIncreased BACE1-AS long noncoding RNA and b-amyloid levels in heart failure.28158647
Heart failureEpigenetic AlterationsAntisense long noncoding RNAs (ncRNAs) are transcripts emerging from the opposite strand of a coding-RNA region and their role in heart failure (HF) is largely unknown.28158647
Hollings Cancer CenterEpigenetic AlterationsWe assessed mRNA and microRNA (miRNA) expression profiles in primary human hepatocytes, liver biopsies and resections of patients with HCC, and analysed microarray and RNA-seq data from paired liver biopsies of patients with HCC.28159835
Malignant Neoplasms, Squamous cell carcinoma of the head and neck, Metastasis, Primary malignant neoplasmEpigenetic AlterationsThe emerging evidence showed that long noncoding RNAs (lncRNAs) are involved in cell growth and apoptosis as well as cancer progression and metastasis of malignant tumor, however, limited data are available on the role of lncRNAs in human papillomavirus (HPV)-associated Head and neck squamous cell carcinomas (HNSCC).28159935
Malignant neoplasm of kidneyEpigenetic AlterationsIt is well known that abnormal DNA methylations occur frequently in kidney cancer.28160561
Carcinoma, Transitional CellEpigenetic AlterationsWe extracted extracellular vesicles from urine of urothelial carcinoma patients and the control group to identify cancer-specific microRNAs in urinary extracellular vesicles as new biomarkers.28160564
Carcinoma, Transitional CellEpigenetic AlterationsFrom the microarray results 5 microRNAs overexpressed in urinary extracellular vesicles of urothelial carcinoma patients were identified.28160564
Multiple MyelomaEpigenetic AlterationsHypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myeloma.28164410
Primary malignant neoplasmEpigenetic AlterationsSignificance of Serum MicroRNAs in the Auxiliary Diagnosis of Non-Small Cell Lung Cancer.28164492
Non-Small Cell Lung CarcinomaEpigenetic AlterationsArea under the curves (AUCs) of serum miR-22, miR-125b, and miR-15b in the diagnosis of NSCLC were 0.725, 0.704, and 0.619, respectively, and the diagnostic significance of these three serum miRNAs for NSCLC was higher than that of serum CEA (AUC = 0.594).28164492
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsSerum miRNAs have potential as NSCLC-screening tumor markers, and serum miR-22 and miR15b might be used as reference indexes for the early diagnosis of NSCLC in the future.28164492
Cardiovascular DiseasesEpigenetic AlterationsMicroRNAs are present in human plasma and have been reported to be biomarkers for cardiovascular diseases.28164501
Breast Carcinoma, NeoplasmsEpigenetic AlterationsPromoter methylation of tumor suppressor genes is an important epigenetic alteration that occurs in the primary stages of human tumors, including breast cancer.28164568
ovarian neoplasm, Metastasis, Primary malignant neoplasmEpigenetic AlterationsOur results therefore demonstrate cancer epigenetics induces a loop of cancer-stroma-cancer interaction in omental microenvironment that promotes peritoneal metastasis of ovarian cancer cells via TNFa-TGFa-EGFR.28166193
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level.28167280
Ischemic strokeEpigenetic AlterationsEpigenetic modification may play an important role in pathophysiology of ischemic stroke (IS) risk.28168424
Fragile X SyndromeEpigenetic AlterationsThis FMR1 5hmC enrichment was not present in cellular models of FXS including fibroblasts, lymphocytes and reprogrammed neurons, indicating they do not fully recapitulate this epigenetic feature of disease.28173181
Stomach CarcinomaEpigenetic AlterationsHypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer.28173803
Stomach CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) act as post-transcriptional regulators of gene expression and modulate the tumorigenesis, including gastric cancer.28173803
Squamous cell carcinoma of the head and neckEpigenetic AlterationsIn vivo experiments validated the in vitro results.Results: Our data identified a four-miRNA signature that classified HNSCC patients at high- or low-risk of recurrence.28174235
Squamous cell carcinomaEpigenetic AlterationsGenome-wide DNA methylation profile identified a unique set of differentially methylated immune genes in oral squamous cell carcinoma patients in India.28174608
Malignant NeoplasmsEpigenetic AlterationsEpigenetic changes, mainly the altered DNA methylation, have been implicated in many cancers.28174608
SERPINB3 wt AlleleEpigenetic AlterationsGenome-wide DNA methylation analysis identified several novel differentially methylated regions associated with OSCC.28174608
SERPINB3 wt AlleleEpigenetic AlterationsDistinct epigenetic drifts for hypo- and hypermethylation across CpG islands suggested independent mechanisms of hypo- and hypermethylation in OSCC development.28174608
Alzheimers DiseaseEpigenetic AlterationsGSK3b 5-flanking DNA Methylation and Expression in Alzheimers Disease Patients.28176663
Concomitant Medication Submission DomainEpigenetic AlterationsWe identified mRNA and miRNA signatures of individual CM traits and their clustering.28178938
Concomitant Medication Submission DomainEpigenetic AlterationsWe identified hundreds of significant associations between mRNAs, miRNAs, and individual CM traits.28178938
Concomitant Medication Submission DomainEpigenetic AlterationsFour mRNAs (FAM13A, CSF2RB, HIST1H2AC, WNK1) were associated with all 6 CM traits (FDR < 0.001) and four miRNAs (miR-197-3p, miR-328, miR-505-5p, miR-145-5p) were associated with four CM traits (FDR < 0.05).28178938
Breast Carcinoma, Mammary NeoplasmsEpigenetic AlterationsDNA Methylation in Breast Tumor from High-risk Women in the Breast Cancer Family Registry.28179314
Alzheimers DiseaseEpigenetic AlterationsProfile of 6 microRNA in blood plasma distinguish early stage Alzheimers disease patients from non-demented subjects.28179587
Admitting diagnosisEpigenetic AlterationsWe confirmed 23 miRNAs reported earlier as AD biomarker candidates in blood and found 26 novel differential miRNAs between AD and control subjects.28179587
palladium, Depression, CTCAEEpigenetic AlterationsWe further described the relationship between these miRNAs and PD with depression (PD-Dep).28181066
Breast CarcinomaEpigenetic AlterationsMicroRNAs miR-7 and miR-340 predict response to neoadjuvant chemotherapy in breast cancer.28181130
Breast CarcinomaEpigenetic AlterationsmiRNAs have been linked to chemosensitivity of breast cancer cells in vitro.28181130
NeoplasmsEpigenetic AlterationsRelative expression of 10 miRNAs likely to be associated with chemotherapy response (miR-7,-21,-29a,-29b,-34a,-125b,-155,-200c,-340,-451) was determined by quantitative RT-PCR from pretherapeutic biopsies (n = 64) and residual invasive tumor after chemotherapy (n = 42).28181130
ObesityEpigenetic AlterationsEpigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events.28181167
Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsEpigenetic mechanisms such as microRNAs (miRs) and DNA methylation may contribute to complications of type 2 diabetes mellitus.28185533
PRKAR1A gene, MEN1 wt AlleleEpigenetic AlterationsMutations in MEN1, PRKAR1A, and DNMT3A in Spitzoid melanomas may indicate involvement of the protein kinase A pathway, or a role of DNA methylation in the disease.28186096
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-196b is an independent prognostic biomarker in patients with pancreatic cancer.28186267
Endometrial Stromal TumorsEpigenetic AlterationsIn this report, we hypothesized that micro-RNA(miR)-1 regulates IL11 and that IL11 promotes high grade endometrial tumour growth.28186993
Adenocarcinoma of large intestineEpigenetic AlterationsGrowing evidence has shown that long non-coding RNAs (lncRNAs) can serve as prospective markers for survival in patients with colorectal adenocarcinoma.28187432
Prostate Cancer PathwayEpigenetic AlterationsA potential panel of four-long noncoding RNA signature in prostate cancer predicts biochemical recurrence-free survival and disease-free survival.28188414
NeoplasmsEpigenetic AlterationsEmerging evidence has shown that microRNAs (miRNAs) play important roles in tumor development and progression.28189678
Clinical CoordinatorEpigenetic AlterationsMicroRNAs are small non-coding RNA molecules whose expression pattern can be altered in various diseases such as CRC.28193082
Clinical CoordinatorEpigenetic AlterationsWe found that the expression levels of miR-4478 and miR-1295b-3p (two previously down-regulated fecal miRNAs) were significantly decreased in FFPE samples of CRC patients compared to healthy controls.28193082
Primary malignant neoplasmEpigenetic AlterationsMicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1.28193514
Colorectal Cancer Pathway, ibudilast, Inflammatory Bowel DiseasesEpigenetic AlterationsIntestinal tissues from patients with inflammatory bowel disease (IBD) and colorectal cancer have increased expression of microRNA-301a (MIR301A) compared with tissues from patients without IBD.28193514
NeoplasmsEpigenetic AlterationsMethylation accumulates during aging in a subset of molecules, suggesting that the epigenetic landscape within a founder-cell population may contribute to tumor formation.28193856
Autoimmune thyroid diseaseEpigenetic AlterationsIntraindividual variation of microRNA expression levels in plasma and peripheral blood mononuclear cells and the associations of these levels with the pathogenesis of autoimmune thyroid diseases.28195542
Hashimoto Disease, Graves Disease, Hodgkin DiseaseEpigenetic AlterationsWe also analysed the expression levels of two of these miRNAs (miR-146a and miR-155) in 20 healthy controls, 60 Graves disease (GD) patients and 50 Hashimotos disease (HD) patients.28195542
Depressive disorderEpigenetic AlterationsInfluence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder.28198448
Minimal Disseminated DiseaseEpigenetic AlterationsOne hundred and fourteen patients with MDD and eighty-eight healthy controls underwent T1-weighted structural magnetic resonance imaging and FKBP5 rs1360780 genotyping, including DNA methylation of intron 7.28198448
Minimal Disseminated DiseaseEpigenetic AlterationsOur findings suggest that the FKBP5 gene and its epigenetic changes could have influence on morphologic changes of several brain regions involved in emotion regulation, and that this process may be associated with the development of MDD.28198448
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA-148a serves as a prognostic factor and suppresses migration and invasion through Wnt1 in non-small cell lung cancer.28199399
Carcinoma of lung, Cancer-Related Death, Primary malignant neoplasmEpigenetic AlterationsLung cancer is the leading cause of cancer death in the world, and aberrant expression of miRNA is a common feature during the cancer initiation and development.28199399
Primary malignant neoplasmEpigenetic AlterationsOur results showed that there were 86 of 159 patients with low miRNA-148a expression and miRNA-148a was significantly down-regulated in primary cancer tissues when compared with their adjacent normal lung tissues.28199399
Cancer Pain, Metastasis, Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsLow expression of miRNA-148a was strongly associated with high tumor grade, lymph node (LN) metastasis and a higher risk of tumor-related death in NSCLC.28199399
Primary malignant neoplasmEpigenetic AlterationsOur data showed that the Wnt1 expression was negatively correlated with the expression of miRNA-148a in both primary cancer tissues and their corresponding adjacent normal lung tissues.28199399
Primary malignant neoplasmEpigenetic AlterationsIn addition, overexpression of miRNA-148a inhibited Wnt1 protein expression in cancer cells.28199399
Carcinoma of lungEpigenetic AlterationsAnd knocking down of Wnt-1 by siRNA had the similar effect of miRNA-148a overexpression on cell migration and invasion in lung cancer cells.28199399
Secondary malignant neoplasm of lungEpigenetic AlterationsIn conclusion, our results suggest that miRNA-148a inhibited cell migration and invasion through targeting Wnt1 and this might provide a new insight into the molecular mechanisms of lung cancer metastasis.28199399
Metastasis, Primary malignant neoplasmEpigenetic AlterationsThese phenomena were compared with epigenetic mechanisms involved in metastasis, as parallel processes of community (biological invasion) and organism (cancer) invasions.28205577
Low Back PainEpigenetic AlterationsA prospective evaluation of microRNA (miRNA) expression in patients with chronic low back pain (CLBP).28207662
Feel PainEpigenetic AlterationsmiRNAs are known to be important mediators of gene regulation in various processes, including pathophysiology of pain.28207662
Clinical CoordinatorEpigenetic AlterationsThe expression of miR-296 was confirmed by qRT-PCR in CRC tissues and cells, and its level was altered by corresponding miRNA vectors.28209128
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsDysregulation of microRNAs (miRNAs) is actively involved in the pathogenesis and tumorigenicity of colorectal cancer (CRC).28209128
Lymphoma, Non-HodgkinEpigenetic AlterationsPlasma DNA methylation of p16 and shp1 in patients with B cell non-Hodgkin lymphoma.28210822
Fibrosis AssessmentEpigenetic AlterationsLiver fibrosis is influenced by patients genomics, including IFNL3 genotype and microRNA expression.28211229
Fibrosis AssessmentEpigenetic AlterationsSerum microRNAs as predictors for liver fibrosis staging in hepatitis C virus-associated chronic liver disease patients.28211229
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA PTENP1 functions as a ceRNA to modulate PTEN level by decoying miR-106b and miR-93 in gastric cancer.28212532
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsLong non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, has been reported to exert its tumor suppressive function via modulation of PTEN expression in many malignancies.28212532
Stomach CarcinomaEpigenetic AlterationsHowever, whether a PTENP1~miRNA~PTEN ceRNA network exists and how it functions in gastric cancer (GC) remains elusive.28212532
NeoplasmsEpigenetic AlterationsThus, we revealed a tumor suppressive role of PTENP1 as ceRNA in GC and pinpointed the specific miRNAs decoyed by PTENP1, highlighting the emerging roles of ceRNAs in the biological regulation of GC cells and their possible clinical significance.28212532
Malignant neoplasm of urinary bladderEpigenetic AlterationsUrinary cell microRNA-based prognostic classifier for non-muscle invasive bladder cancer.28212556
NeoplasmsEpigenetic AlterationsThe risk score derived from the model containing these two microRNAs was able to discriminate between two groups with a highly significant different probability of tumour progression (HR, 5.204; p<0.001) which was maintained when patients were stratified according to tumour risk.28212556
Multiple MyelomaEpigenetic AlterationsPrognostic role of circulating exosomal miRNAs in multiple myeloma.28213378
Cardiovascular DiseasesEpigenetic AlterationsWe report novel associations of DNA methylation with lipid levels, describe epigenetic mechanisms related to previous genome-wide association studies discoveries, and provide evidence implicating epigenetic regulation of reverse cholesterol transport in blood in relation to occurrence of cardiovascular disease events.28213390
Coronary Artery DiseaseEpigenetic AlterationsEpigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies.28213390
Squamous cell carcinoma of lungEpigenetic AlterationsImplication of downregulation and prospective pathway signaling of microRNA-375 in lung squamous cell carcinoma.28214218
Colorectal Cancer PathwayEpigenetic AlterationsThe Novel Long Noncoding RNA TUSC7 Inhibits Proliferation by Sponging MiR-211 in Colorectal Cancer.28214867
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsThe novel long noncoding RNA (lncRNA) tumor suppressor candidate 7 (TUSC7) has been reported as a potential tumor suppressor, while the functional role of TUSC7 is still unknown in colorectal cancer (CRC).28214867
Intracranial AneurysmEpigenetic AlterationsOur previous microarray results identified numerous microRNAs (miRNAs), including miR-29b, that were differentially expressed in the serum of intracranial aneurysm (IA) patients.28214880
Clinical CoordinatorEpigenetic AlterationsTaken together, the findings of our study demonstrate that miR-506 overexpression in HCT116-OxR cells enhances oxaliplatin sensitivity by inhibiting MDR1/P-gp expression via down-regulation of the Wnt/b-catenin pathway and thus provide a rationale for the development of miRNA-based strategies to reverse oxaliplatin resistance in CRC cells.28217977
Childhood LeukemiaEpigenetic AlterationsOur results suggest that leukemia microvesicles are able to induce some effects on healthy hematopoietic stem cells such as promoting cell survival and some microRNAs deregulation, while stemness is maintained.28218044
Liver carcinomaEpigenetic AlterationsMiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5.28218742
Metastasis, Primary malignant neoplasmEpigenetic AlterationsIdentification of miRNAs related to metastasis enables us to obtain better insight into cancer development.28218742
Liver carcinomaEpigenetic AlterationsAltogether, our data indicate that the levels of these miRNAs may be used as biological markers for evaluating hepatocellular carcinoma progression.28218742
prostatitis, Erectile dysfunctionEpigenetic AlterationsA Variant in the Precursor of MicroRNA-146a is Responsible for Development of Erectile Dysfunction in Patients with Chronic Prostatitis via Targeting NOS1.28218896
Degenerative polyarthritisEpigenetic AlterationsClarifying epigenetic mechanisms of 5hmC induced by TWIST1 is a critical molecule to understanding OA pathogenesis.28220902
Leukemia, Myelocytic, AcuteEpigenetic AlterationsAberrant DNA methylation is known to occur in patients with acute myeloid leukemia (AML), whereas methylation signatures and prognostic markers have been proposed.28222251
Malignant neoplasm of urinary bladderEpigenetic AlterationsMicroRNA-223-3p inhibits human bladder cancer cell migration and invasion.28222670
Breast CarcinomaEpigenetic AlterationsMechanisms underlying the inverse association between physical activity and survival after breast cancer are unresolved, but DNA methylation may play a role.28222775
Parkinson DiseaseEpigenetic AlterationsMicroRNA biomarkers of Parkinsons disease in serum exosome-like microvesicles.28223160
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsmiRNAs function as tumor suppressors and oncogenes in various cancers and regulate the differentiation potential of hematopoietic stem and progenitor cells (HSPCs).28224273
SF3B1 wt AlleleEpigenetic AlterationsIt has been suggested that miRNAs may play an important role in progression of MDS.28224273
Herpes zoster disease, Postherpetic neuralgiaEpigenetic AlterationsComparing serum microRNA levels of acute herpes zoster patients with those of postherpetic neuralgia patients.28225487
Malignant - descriptorEpigenetic AlterationsAberrant expression of the microRNA miR-122 has frequently been reported in malignant cancers.28231730
Stomach CarcinomaEpigenetic AlterationsIt is necessary to uncover the detailed pattern of whole genome-wide abnormal DNA methylation during the development of gastric cancer (GC).28231797
Malignant neoplasm of endometriumEpigenetic AlterationsLong non-coding RNA LINC00672 contributes to p53 protein-mediated gene suppression and promotes endometrial cancer chemosensitivity.28232485
Prostate carcinomaEpigenetic AlterationsFurther TSPYL5 gene and protein expression in prostate carcinoma cells and diseased tissues including its susceptibility for epigenetic silencing is unknown.28235398
Carcinogenesis, NeoplasmsEpigenetic AlterationsEpigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance.28235630
Degenerative polyarthritisEpigenetic AlterationsAccumulating evidence suggests that microRNAs (miRNAs) are associated with OA, but little is known of their function in chondrocyte ECM degradation.28236026
ovarian neoplasmEpigenetic AlterationsDNA methylation is well-known to be associated with ovarian cancer (OC) and has great potential to serve as a biomarker in monitoring response to therapy and for disease screening.28241454
cervical cancerEpigenetic AlterationsA panel of patients with cervical cancer was selected and the importance of the histone modifications concerning survival-time (overall survival and relapse-free survival) was analyzed in 250 cases.28241481
cervical cancer, Primary malignant neoplasmEpigenetic AlterationsAlthough cervical cancer is the fourth most common cancer in women worldwide, a systematic study about the prognostic value of specific changes in the chromatin structure, such as histone acetylation or histone methylation, is missing.28241481
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsThe expression pattern and biological role of long non-coding RNA (lncRNA) in cancer has been reported to be involved in many cancers.28245089
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers.28245474
Breast CarcinomaEpigenetic AlterationsPrognostic significance of long noncoding RNA Z38 as a candidate biomarker in breast cancer.28247935
Breast CarcinomaEpigenetic AlterationsLong noncoding RNA (lncRNA) Z38 has been shown to promote cell proliferation and tumorigenesis in breast cancer.28247935
Glioblastoma MultiformeEpigenetic AlterationsA three-microRNA signature identifies two subtypes of glioblastoma patients with different clinical outcomes.28248456
Primary malignant neoplasmEpigenetic AlterationsBy a combined inferential strategy on PCA results, we identified a reduced set of three miRNAs - miR-23a, miR-27a, and miR-9* (miR-9-3p) - able to discriminate the proneural- and mesenchymal-like GSC phenotypes as well as mesenchymal and proneural subtypes of primary GBM included in The Cancer Genome Atlas (TCGA) data set.28248456
Ischemic stroke, IschemicEpigenetic AlterationsDistinctive expression signatures of serum microRNAs in ischaemic stroke and transient ischaemic attack patients.28251236
Ischemic strokeEpigenetic AlterationsCirculating microRNAs (miRNAs) have recently emerged as promising biomarkers for ischaemic stroke (IS).28251236
Transient Ischemic AttackEpigenetic AlterationsMarkedly altered miRNAs were subsequently validated by individual quantitative reverse-transcription PCR (qRT-PCR) assays first in the same cohort of TLDA and further confirmed in another larger cohort including 177 IS, 81 TIA patients and 42 controls.28251236
Cerebrovascular accident, Transient Ischemic Attack, Neurologic DeficitsEpigenetic AlterationsLogistic regression and receiver-operating characteristic curve analyses demonstrated that these altered miRNAs may function as predictive and discriminative biomarkers for IS and TIA, and their distinctive expression signatures may contribute to assessing neurological deficit severity of IS and subsequent stroke risk after TIA.28251236
Admitting diagnosis, "Alzheimers Disease", Neurodegenerative DisordersEpigenetic AlterationsAberrant DNA methylation has been observed in the patients with Alzheimers disease (AD), a common neurodegenerative disorder in the elderly.28253273
Carcinoma of lung, Metastasis, Adenocarcinoma of lung (disorder)Epigenetic AlterationsRecently studies have demonstrated that the long non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) may participate in the development and progression of lung cancer.28253859
ParagangliomaEpigenetic AlterationsGenetic and epigenetic patterns in patients with the head-and-neck paragangliomas associate with differential clinical characteristics.28255624
Drug-Induced Liver DiseaseEpigenetic AlterationsLiver-enriched microRNA-122 (miR-122) is a novel circulating biomarker for drug-induced liver injury (DILI).28257154
Primary malignant neoplasmEpigenetic AlterationsRecently, DNA methylation-based marker of ageing, known as epigenetic clock, has been linked with cancer risk factors.28259012
Postmenopausal stateEpigenetic AlterationsDNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility.28259012
Breast CarcinomaEpigenetic AlterationsEpigenetic age acceleration and CpG island methylation have a weak, but statistically significant, association with breast cancer susceptibility.28259012
Heart failureEpigenetic AlterationsCirculating microRNAs (miRs) are promising biomarkers for heart failure (HF).28259597
Hollings Cancer Center, Liver carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic disruption of tumor suppressor genes (TSGs), particularly DNA methylation, plays a key role in hepatocellular carcinoma (HCC) pathogenesis.28259820
Hollings Cancer CenterEpigenetic AlterationsThus, epigenetic suppression of BCLB expression is involved in HCC development, which might have therapeutic implications for HCC patients.28259820
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsIdentification of the long non-coding RNA LET as a novel tumor suppressor in gastric cancer.28260083
Malignant NeoplasmsEpigenetic AlterationsMicroRNA-9 (miR-9) has been confirmed to be dysregulated in many types of cancers.28260112
Malignant NeoplasmsEpigenetic AlterationsAberrant expression of microRNAs (miRNAs) plays an important role in the MDR of various types of cancers.28260112
Malignant Neoplasms, Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsThe deregulation of microRNA (miRNA) is frequently associated with a variety of cancers, including hepatocellular carcinoma (HCC).28261837
Hollings Cancer CenterEpigenetic AlterationsTherefore, miR-199a-5p may serve as a useful therapeutic agent for miRNA-based HCC therapy.28261837
Malignant Neoplasms, Clinical Coordinator, MetastasisEpigenetic AlterationsAlthough microRNAs (miRNAs) are a class of small noncoding RNAs frequently deregulated in various human malignancies, it remains unknown if these can help predict recurrence and metastasis in CRC patients.28262692
Clinical CoordinatorEpigenetic AlterationsCandidate miRNAs were then tested in two independent cohorts of 111 stage II/III and 139 stage I-III CRC patients, as well as serum samples and matched primary and metastatic liver tissues.28262692
Childhood LeukemiaEpigenetic AlterationsThrough a comparative sequencing and analysis of RNA content between the MVs from RPMI8226 MM cells (RPMI8226-MVs) and K562 leukemia cells, RPMI8226-MVs were enriched with more renal-pathogenic miRNAs, in which the selective miRNAs may participate in the up-regulation of the levels of cleaved caspase-3.28264449
Stomach Carcinoma, MetastasisEpigenetic AlterationsLong non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis.28268166
oligodendrogliomaEpigenetic AlterationsGenetic and epigenetic stability of oligodendrogliomas at recurrence.28270234
oligodendroglioma, NeoplasmsEpigenetic AlterationsTo elucidate the genetic and epigenetic background for such behavior and tumor evolution during tumor relapse, we comparatively analyzed 12 pairs of primary and recurrent oligodendrogliomas with 1p/19q-codeletion.28270234
Well Differentiated Oligodendroglioma, oligodendroglioma, NeoplasmsEpigenetic AlterationsIn summary, although oligodendroglioma displays marked mutational heterogeneity, histological malignant transformation accompanying events such as considerable increase in mutation number and epigenetic profile change were not observed at recurrence, indicating that noticeable temporal and spatial genetic heterogeneity in oligodendrogliomas does not result in rapid tumor progression.28270234
Colorectal Cancer PathwayEpigenetic AlterationsEpigenome-wide discovery and evaluation of leukocyte DNA methylation markers for the detection of colorectal cancer in a screening setting.28270869
Clinical CoordinatorEpigenetic AlterationsAlthough diagnostic performance of the DNA methylation signature identified in this first epigenome-wide association study of leukocyte DNA methylation with CRC in a screening setting is not competitive with established screening tests, the identified markers may contribute to multimarker panels for early detection of CRC.28270869
Liver carcinomaEpigenetic AlterationsLong non-coding RNA UCA1 regulates the expression of Snail2 by miR-203 to promote hepatocellular carcinoma progression.28271214
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsLong non-coding RNA (LncRNA) urothelial carcinoma-associated 1 (UCA1) is reported to be dysregulated in hepatocellular carcinoma (HCC) progression.28271214
Heart failureEpigenetic AlterationsSeveral studies have suggested circulating microRNAs (miRs) are associated with heart failure, but these studies were small, and limited to single miR measurements.28274577
Small cell carcinoma of lung, NeoplasmsEpigenetic AlterationsThe microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes.28275243
Small cell carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsElucidation of differentially expressed miRNA-mediated cancer pathways based on SCLC signature may provide new insights into the mechanisms of SCLC pathogenesis.28275243
Lichen PlanusEpigenetic AlterationsGene expression of miRNA-138 and cyclin D1 in oral lichen planus.28275859
Breast Carcinoma, Mammary NeoplasmsEpigenetic AlterationsBreast tumor DNA methylation patterns associated with smoking in the Carolina Breast Cancer Study.28275920
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsAltered DNA methylation contributes to breast cancer development and may provide a mechanistic link between smoking and gene expression changes leading to cancer development or progression.28275920
TraumaticEpigenetic AlterationsMicroRNAs as Novel Biomarkers for the Diagnosis and Prognosis of Mild and Severe Traumatic Brain Injury.28279125
Degenerative polyarthritisEpigenetic AlterationsIncreased GPD1L and decreased miRNA-181a were observed in tissues from osteoarthritis patients.28280258
Adult T-Cell Lymphoma/LeukemiaEpigenetic AlterationsWe profiled miRNAs in Pten-deficient mouse T-ALL and identified miR-26b as a potentially dysregulated gene.28280276
Small cell carcinoma of lungEpigenetic AlterationsThese findings suggest that miRNA-related polymorphisms in the PI3K/Akt/mTOR pathway may be valuable biomarkers to complement clinicopathological variables in predicting prognosis of limited-disease SCLC and to facilitate selection of patients likely to benefit from chemoradiotherapy.28280736
Merkel cell carcinomaEpigenetic AlterationsWe speculated that the paucity of mutations in virus-positive Merkel cell carcinoma may reflect a pathomechanism that depends on derangements of chromatin without alterations in the DNA sequence (epigenetic dysregulation).28281550
Merkel cell carcinoma, NeoplasmsEpigenetic AlterationsOur findings suggest that a PRC2-mediated epigenetic deregulation may play a role in the pathogenesis of virus-positive Merkel cell carcinomas and in tumors with pure histologic features.28281550
NeoplasmsEpigenetic AlterationsRecently, Accumulating evidence indicates that long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in human tumor biology and development.28282787
Stomach CarcinomaEpigenetic AlterationsExosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression.28285404
Metastasis, NeoplasmsEpigenetic AlterationsZFAS1 is a newly identified long noncoding RNA (lncRNA) that promotes tumor growth and metastasis.28285404
Chronic Kidney Diseases, Fibrosis AssessmentEpigenetic AlterationsRenal fibrosis is a common pathological feature of chronic kidney diseases (CKD) and its development and progression are significantly affected by epigenetic modifications such as aberrant miRNA and DNA methylation.28285987
Injury of kidneyEpigenetic AlterationsKlotho is an anti-aging and anti-fibrotic protein and its early decline after renal injury is reportedly associated with aberrant DNA methylation.28285987
Esophageal carcinomaEpigenetic AlterationsMicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF.28288140
Primary malignant neoplasmEpigenetic AlterationsThe discovery of microRNAs created a new milestone in cancer research.28288140
Clinical Coordinator, Ulcerative Colitis, DysplasiaEpigenetic AlterationsAberrant miRNA expression is a feature of sporadic CRC but much less is known about the changes that occur in dysplasia and in UC.28288169
DysplasiaEpigenetic AlterationsIn particular, levels of miR-200b-3p were increased in dysplasia, and this miRNA was localised to epithelial cells in dysplastic lesions and in UC cancers.28288169
Inflammatory polyp, Ulcerative ColitisEpigenetic AlterationsThe expression of miRNAs in UC post inflammatory polyps (n = 7) was also assessed.28288169
Cardiovascular DiseasesEpigenetic AlterationsThere is increasing interest in extracellular RNAs (ex-RNAs), with numerous reports of associations between selected microRNAs (miRNAs) and a variety of cardiovascular disease phenotypes.28289238
Colorectal Cancer PathwayEpigenetic AlterationsThe dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer.28293327
NeoplasmsEpigenetic AlterationsExpression of mutL homolog 1 (MLH1), a mismatch repair gene that corrects DNA replication errors, is lost in up to 15% of sporadic tumours due to mutation or, more commonly, due to DNA methylation of its promoter CpG island.28293327
Clinical Coordinator, Familial Colorectal Cancer Type X, Colorectal Neoplasms, NeoplasmsEpigenetic AlterationsTo determine whether this genotype-epigenotype association is present in other tissue types, including colorectal tumours, we assessed DNA methylation in matched normal colorectal tissue, tumour, and PBMC DNA from 349 population-based CRC cases recruited from the Ontario Familial Colorectal Cancer Registry.28293327
Colorectal CarcinomaEpigenetic AlterationsColorectal cancers (CRCs) undergo distinct genetic and epigenetic alterations.28293327
NeoplasmsEpigenetic AlterationsThese results indicate that the normal tissue types tested (colorectum and PBMC) experience dynamic genotype-associated epigenetic alterations at the MLH1 shore, whereas tumour DNA incurs aberrant hypermethylation compared to normal DNA.28293327
Abnormality of mitochondrial metabolism, Kidney Failure, AcuteEpigenetic AlterationsDifferentially expressed miRNAs in sepsis-induced acute kidney injury target oxidative stress and mitochondrial dysfunction pathways.28296904
Primary malignant neoplasm, Intrahepatic Route of Drug AdministrationEpigenetic AlterationsHere, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme.28297679
Cushing SyndromeEpigenetic AlterationsPatients with Cushings Syndrome (CS) in remission were used as a model to test the hypothesis that long-standing excessive cortisol exposure induces changes in DNA methylation that are associated with persisting neuropsychological consequences.28300138
Liver carcinomaEpigenetic AlterationsMoreover, we observed extensive intratumoral epigenetic heterogeneity in hepatocellular carcinoma based on multiple independent analytical methods and showed that intratumoral methylation heterogeneity might play important roles in the biology of hepatocellular carcinoma cells.28302680
CarcinomaEpigenetic AlterationsCarcinoma follows a course of multiple changes that are affected by several important factors, with epigenetic silencing of the promoter gene being one of them.28303350
CarcinogenesisEpigenetic AlterationsA series of studies have suggested that epigenetic changes in the anti-aging gene Klotho may be one of the emerging areas of concern in the study of carcinogenesis.28303350
CarcinomaEpigenetic AlterationsWe hypothesized that epigenetic silencing of Klotho due to hypermethylation of DNMT3a may be one of the causes of carcinoma in the oral and maxillofacial region.28303350
Primary malignant neoplasmEpigenetic AlterationsAlterations in microRNA expression associated with alcohol consumption in rectal cancer subjects.28303484
Primary malignant neoplasmEpigenetic AlterationsOur results suggest that wine influences miRNA expression in rectal cancer, supporting the hypothesis that components in alcohol influence miRNA expression.28303484
Neoplasm MetastasisEpigenetic AlterationsNext-generation Sequencing for microRNA Profiling: MicroRNA-21-3p Promotes Oral Cancer Metastasis.28314265
Squamous cell carcinoma, SERPINB3 wt AlleleEpigenetic AlterationsDysfunctional microRNAs (miRNAs) play a crucial role in oral squamous cell carcinoma (OSCC) progression.28314265
SERPINB3 wt AlleleEpigenetic AlterationsWe observed that 45 miRNAs were substantially up-regulated and 17 miRNAs were down-regulated in OSCC tissues.28314265
Clinical CoordinatorEpigenetic AlterationsThe combination of genetic mutations and epigenetic aberrations specifically in CTCs, will ameliorate CRC diagnosis in the future.28314271
Degenerative polyarthritisEpigenetic AlterationsEpigenetic mechanisms have been reported to play key roles in chondrogenesis and osteoarthritis (OA) development.28314754
Degenerative polyarthritisEpigenetic AlterationsUnderstanding the epigenetic mechanism of joint cartilage development and homeostasis would be useful for development of new therapeutic modalities for OA.28314754
NeoplasmsEpigenetic AlterationsThe microRNAs (miRNAs) are involved in multiple pathological processes among various types of tumors.28315020
NeoplasmsEpigenetic AlterationsHowever, the functions of miRNAs in benign brain tumors are largely unexplored.28315020
Pituitary AdenomaEpigenetic AlterationsOur result can provide the evidence on featured miRNAs which play a prominent role in pituitary adenoma as effective biomarkers and therapeutic targets in the future.28315020
AMD1 wt AlleleEpigenetic AlterationsCirculating miRNA levels were significantly varied in AMD patients.28315863
AMD1 wt AlleleEpigenetic AlterationsThree miRNAs, miR-27a-3p, miR-29b-3p and the miR-195-5p, might be potential diagnostic biomarkers for AMD.28315863
Primary malignant neoplasmEpigenetic AlterationsIncreasing evidence suggests that aberrant microRNAs expressions are significantly associated with cancer progression.28317618
NeoplasmsEpigenetic AlterationsDNA methylation, especially promoter methylation, which causes the silence/decrease of tumour related genes, has become a focus in various tumour types.28319413
NeoplasmsEpigenetic AlterationsEpigenetics, including many oncogenes or tumour suppressor genes, can provide some clues for this kind of disorder.28319413
InflammationEpigenetic AlterationsMicroRNA-155, which has been shown to play a central role in inflammation and neovascularization, was upregulated with long-term LVAD support.28319523
Heart failureEpigenetic AlterationsMicroRNAs (miRNAs) are 22-23 nucleotide RNAs involved in regulation of multiple biologic processes including the pathogenesis of heart failure (HF).28319523
Primary malignant neoplasmEpigenetic AlterationsThe use of circulating microRNAs as biomarkers has opened new opportunities for diagnosis of cancer because microRNAs exhibit tumor-specific expression profiles.28321148
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsTo screen clinically relevant microRNAs (miRNAs) silenced by DNA methylation in human hepatocellular carcinoma (HCC).28321157
Liver neoplasms, Hepatocellular Adenoma, MIR183 wt AlleleEpigenetic AlterationsDNA methylation analysis in healthy liver, benign liver tumors (hepatocellular adenoma and focal nodular hyperplasia) and their corresponding adjacent tissues showed absence of hypermethylation supporting the notion that aberrant methylation at hsa-miR-183 is specific for the malignant transformation of hepatocytes.28321157
Hollings Cancer CenterEpigenetic AlterationsmiRNA profiling after DNMT knockdown in HCC cell lines revealed upregulation of miR-23, miR-25 and miR-183.28321157
Rheumatoid ArthritisEpigenetic AlterationsMicroRNA-192 suppresses cell proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes by downregulating caveolin 1.28321538
Immune System DiseasesEpigenetic AlterationsEpigenetic mechanisms are critical for normal immune development and epigenetic alterations might therefore be possible contributors to immune diseases.28322575
S100A4 protein, humanEpigenetic AlterationsThe dysregulation of histone acetylation can lead to the uncontrolled activity of different genes, thereby triggering events associated with malignant transformation.28326594
CarcinogenesisEpigenetic AlterationsOral carcinogenesis is influenced by modifications in epigenetic mechanisms, including changes in histones, which are proteins that support chromatin remodelling for the dynamic regulation of gene expression and silencing.28326594
Hypopharyngeal CarcinomaEpigenetic AlterationsUpregulation of the long noncoding RNA UCA1 affects the proliferation, invasion, and survival of hypopharyngeal carcinoma.28327194
ovarian neoplasmEpigenetic AlterationsClinical validation of chemotherapy predictors developed on global microRNA expression in the NCI60 cell line panel tested in ovarian cancer.28334047
Primary malignant neoplasmEpigenetic AlterationsPredictors of chemotherapy-resistance were developed based on correlation between miRNA expression and differences in measured growth inhibition in a variety of human cancer cell lines in the presence of Carboplatin, Paclitaxel and Docetaxel.28334047
Malignant Peripheral Nerve Sheath TumorEpigenetic AlterationsWe observed that most patients with two MPNs harbored mutations in genes known to contribute to clonal hematopoiesis through altered epigenetic regulation such as TET2, ASXL1/2, SRSF2, and IDH2 at varying frequencies (1%-47%).28335073
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsSerum microRNA Expression Profiling: Potential Diagnostic Implications of a Panel of Serum microRNAs for Clear Cell Renal Cell Cancer.28336290
Primary malignant neoplasmEpigenetic AlterationsTS levels were found to be significantly augmented in mesenchymal-like compared to epithelial-like cancer cells, to be regulated by EMT induction, and to negatively correlate with micro-RNAs (miRNAs) usually expressed in epithelial-like cells and known to actively suppress EMT.28337746
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsLong non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer.28338293
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsHere, we found that the long non-coding RNA 00312 was down-regulated in paired NSCLC tissues and correlated with poor clinical outcome; decreased linc00312 expression in NSCLC was associated with larger and later stage tumours.28338293
NeoplasmsEpigenetic AlterationsThe abnormal expression of many long non-coding RNAs (lncRNAs) has been reported involved in the progression of various tumours, which can be used as diagnostic indicators or antitumour targets.28338293
Carcinoma of lung, Non-Small Cell Lung CarcinomaEpigenetic AlterationsIdentification of circulating long non-coding RNA GAS5 as a potential biomarker for non-small cell lung cancer diagnosisnon-small cell lung cancer, long non-coding RNA, plasma, GAS5, biomarker.28339045
Primary malignant neoplasm, Non-Small Cell Lung CarcinomaEpigenetic AlterationsIncreasing evidence suggest that long non-coding RNA GAS5 plays vital roles in cancer proliferation and differentiation in NSCLC.28339045
Stomach CarcinomaEpigenetic AlterationsMicroRNA-499 rs3746444 A/G polymorphism functions as a biomarker to predict recurrence following endoscopic submucosal dissection in primary early gastric cancer.28339066
Stomach CarcinomaEpigenetic AlterationsOnline microRNA (miRNA) target prediction tools were used, which identified PDGFRB as the candidate target gene of miR-499a in gastric cancer cells, and PFGRBR was then confirmed as the direct gene using a luciferase reporter assay system.28339066
Sjogrens Syndrome", Lupus ErythematosusEpigenetic AlterationsMicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjogrens syndrome.28339495
Autoimmune DiseasesEpigenetic AlterationsHowever, a given miRNA may have hundreds of different mRNA targets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated miRNA expression profiles could give a better insight into the development of immunological disturbances in autoimmune diseases.28339495
Peripheral, Lupus Erythematosus, Systemic, Perceived stress scale, Hyperactive behaviorEpigenetic AlterationsSince the immunopathogenesis of pSS and SLE encompasses pronounced B cell hyperactivity along with specific autoantibody production, we paid a special attention on the association between miRNA expression levels and altered peripheral B cell distribution.28339495
Lupus Erythematosus, Systemic, Perceived stress scaleEpigenetic AlterationsThe observed differences in miRNA expression profiles and the better understanding of immune regulatory mechanisms of miRNAs may help to elucidate the pathogenesis of SLE and pSS.28339495
Lupus Erythematosus, SystemicEpigenetic AlterationsIn SLE patients 135, while in pSS patients 26 miRNAs showed altered expression.28339495
Lupus Erythematosus, Systemic, Perceived stress scaleEpigenetic AlterationsInterestingly, the 25 miRNAs including miR-146a, miR-16 and miR-21, which were over-expressed in pSS patients, were found to be elevated in SLE group, as well.28339495
Stomach CarcinomaEpigenetic AlterationsThe Profile of Serum microRNAs Predicts Prognosis for Resected Gastric Cancer Patients Receiving Platinum-Based Chemotherapy.28341869
ObesityEpigenetic AlterationsThere is growing evidence that circulating microRNAs (miRNAs) play an important role in obesity.28342299
Weight Gain, Obesity, Weight decreasedEpigenetic AlterationsThe findings provide evidence that circulating miRNAs play important roles in obesity and weight gain and suggest new targets for understanding the mechanisms of weight gain and developing weight loss intervention strategies.28342299
Coronary Artery Disease, HypercholesterolemiaEpigenetic AlterationsTranslating the microRNA signature of microvesicles derived from human coronary artery smooth muscle cells in patients with familial hypercholesterolemia and coronary artery disease.28342976
Family historyEpigenetic AlterationsExposure to atherogenic lipoproteins modifies the miRNA profile of CASMC-derived microvesicles and these alterations are reflected in patients with FH.28342976
Transitional cell carcinoma of ureterEpigenetic AlterationsGenetic and epigenetic alterations play an important role in urothelial cancer pathogenesis.28344356
NeoplasmsEpigenetic AlterationsMicroRNAs are emergent players of epigenetics that function as oncogenes or tumor suppressors and that have been implicated in regulating diverse cellular pathways.28345456
Malignant Neoplasms, Metastasis, NeoplasmsEpigenetic AlterationsMiR-10b is an oncogenic microRNA involved in tumor invasion and metastasis in various cancers.28345456
Colorectal Cancer PathwayEpigenetic AlterationsCoactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer.28345460
Colorectal Cancer PathwayEpigenetic AlterationsRemarkably, restoration of coactivator-associated arginine methyltransferase 1 in microRNA-195-5p-transfected colorectal cancer cells partially abrogated the inhibition of cell proliferation and colony formation mediated through microRNA-195-5p.28345460
Colorectal Cancer PathwayEpigenetic AlterationsThese data confirm that microRNA-195-5p might function as an anti-tumor microRNA in colorectal cancer exerting critical control over coactivator-associated arginine methyltransferase 1 expression.28345460
Colorectal Cancer PathwayEpigenetic AlterationsThe newly identified microRNA-195-5p/coactivator-associated arginine methyltransferase 1 axis may act as a novel promising therapeutic target for colorectal cancer treatment.28345460
NeoplasmsEpigenetic AlterationsmiR-9 was initially identified as an epigenetically regulated miRNA in tumours, but inconsistent findings have been reported so far.28345661
NeoplasmsEpigenetic AlterationsNo significant correlation between promoter methylation and pri-miRNAs expressions was found either in tumours or in NBTs.28345661
Gastric Cardia AdenocarcinomaEpigenetic AlterationsPromoter hypermethylation-mediated downregulation of miR-770 and its host gene MEG3, a long non-coding RNA, in the development of gastric cardia adenocarcinoma.28345805
CO-methylating acetyl-CoA synthase activityEpigenetic AlterationsOur results may suggest that immune signaling and cellular functions might be regulated at an epigenetic level in ACS.28348007
Glioblastoma Multiforme PathwayEpigenetic AlterationsUpregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial-mesenchymal transition in vitro and predicts poor prognosis in glioma.28349823
Glioblastoma Multiforme PathwayEpigenetic AlterationsZinc finger antisense 1 is a novel long noncoding RNA whose clinical significance, biological function, and underlying mechanism are still undetermined in glioma.28349823
Malignant NeoplasmsEpigenetic AlterationsIncreasing evidence indicates that long noncoding RNAs play important roles in development and progression of various cancers.28349823
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNA signature is altered in different disease states including cancer, and some microRNAs act as oncogenes or tumor suppressors.28349829
MeningiomaEpigenetic AlterationsExpression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma.28349893
MeningiomaEpigenetic Alterationsthe association between miRNA expression and meningioma, is continuously gaining more importance in the wider context of the recent developments in genetic treatments.28349893
cervical cancerEpigenetic AlterationsAberrant gene-specific DNA methylation signature analysis in cervical cancer.28351298
cervical cancer, Cervical Intraepithelial NeoplasiaEpigenetic AlterationsMulticomponent molecular modifications such as DNA methylation may offer sensitive and specific cervical intraepithelial neoplasia and cervical cancer biomarkers.28351298
Malignant NeoplasmsEpigenetic AlterationsIn recent years, studies on the mechanisms of lung tumorigenesis and development have in part focused on the microRNAs for their crucial role in the progress of different cancers.28351305
Aggressive behavior, NeoplasmsEpigenetic AlterationsOf the three differentially expressed circulating miRNA, miRNA192 was significantly increased both in circulation and in tumour tissue and correlated with tumour stage and aggressiveness (r = 0.96, P < 0.0001).28351309
Periampullary carcinomaEpigenetic AlterationsSince the prognosis for pancreatobiliary subtype of periampullary carcinoma is poor, we assessed the prognostic relevance of miRNAs in combination with CA19-9 as noninvasive biomarker in periampullary carcinoma.28351309
NeoplasmsEpigenetic AlterationsTumour tissues were subjected to staging and subtyping prior to determining differentially expressed miRNAs in them by quantitative real-time polymerase chain reaction (qRT-PCR).28351309
Degenerative polyarthritisEpigenetic AlterationsMiRNA expression in the cartilage of patients with osteoarthritis.28351380
Clinical Coordinator, Colorectal Cancer Pathway, Primary malignant neoplasmEpigenetic AlterationsAberrant DNA methylation profiles are a characteristic of all known cancer types, epitomized by the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC).28351398
Clinical CoordinatorEpigenetic AlterationsDNA methylation in CRC was analysed using the Illumina HumanMethylation450K array.28351398
Colorectal Cancer PathwayEpigenetic AlterationsOur genome-wide characterization of DNA methylation in colorectal cancer has identified 132 genes hypermethylated in 100% of CIMP-H samples.28351398
Rheumatoid ArthritisEpigenetic AlterationsDNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis.28356135
melanomaEpigenetic AlterationsCirculating microRNA-194 regulates human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway.28358423
melanomaEpigenetic AlterationsWe found that microRNA-194 expression was markedly suppressed in human melanoma patients, compared with negative control group.28358423
melanomaEpigenetic AlterationsTaken together, these data indicate that circulating microRNA-194 regulated human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway.28358423
Cirrhotic, Liver carcinomaEpigenetic AlterationsA Circulating MicroRNA Signature Capable of Assessing the Risk of Hepatocellular Carcinoma in Cirrhotic Patients.28364124
Cirrhotic, Hollings Cancer CenterEpigenetic AlterationsIn summary, a circulating miRNA-based score was developed that is capable of assessing HCC risks in cirrhotic patients.28364124
Malignant NeoplasmsEpigenetic AlterationsDysregulation of miRNAs is noted in many cancers, and circulating miRNAs can be readily assayed.28364124
Adenocarcinoma of lung (disorder)Epigenetic AlterationsLung adenocarcinomas are characterized by a variety of genetic and epigenetic changes that lead to activation of specific signaling pathways.28364271
Hollings Cancer Center, Primary malignant neoplasmEpigenetic AlterationsMiRNA and mRNA expression data for HCC were accessed from The Cancer Genome Atlas (TCGA).28365450
Liver carcinomaEpigenetic AlterationsmiRNA-101-1 and miRNA-221 expressions and their polymorphisms as biomarkers for early diagnosis of hepatocellular carcinoma.28366737
Hollings Cancer CenterEpigenetic AlterationsOf these miRNAs, are miR-221 and miR-101-1, which their aberrant expressions have been reported to play an important role in HCC.28366737
Alzheimers DiseaseEpigenetic AlterationsThese data suggest that interrelated diurnal and seasonal epigenetic and transcriptional rhythms may be an important feature of human brain biology, and perhaps human biology more broadly, and that changes in such rhythms may be consequences of, or contributors to, diseases such as Alzheimers disease.28368004
Degenerative polyarthritis, Rheumatoid Arthritis, Kashin-Beck DiseaseEpigenetic AlterationsComparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis.28373711
Kabardian languageEpigenetic AlterationsAnother independent mRNA expression profile dataset of 20 KBD patients and 15 healthy controls were integrated with the miRNA expression profiles of KBD.28373711
Degenerative polyarthritis, Right armEpigenetic AlterationsOur results demonstrated the altered miRNAs expression profiles of KBD comparing to healthy controls, OA and RA, which provide novel clues for clarifying the mechanism of KBD.28373711
Myeloid Leukemia, ChronicEpigenetic AlterationsThus far, the mechanism of epigenetic silencing of the SHP-1 tyrosine phosphatase gene that occurs in chronic myelogenous leukemia cells remains poorly understood.28376405
Squamous cell carcinoma of esophagusEpigenetic AlterationsHOX transcript antisense RNA (HOTAIR), a long noncoding RNA (lncRNA) expressed from the HOXC locus, has been recently revealed as an oncogenic regulator in ESCC.28376832
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been reported to regulate the sensitivity of different cancer cells to chemoradiotherapy.28376901
ELN wt AlleleEpigenetic AlterationsWhile the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased epigenetic age according to a DNA methylation based biomarker of aging (the "Epigenetic Clock").28377537
Werner SyndromeEpigenetic AlterationsAccelerated epigenetic aging in Werner syndrome.28377537
Salivary Gland NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs), small noncoding RNAs, and posttranscriptional regulators of mRNA are poorly described in different subtypes of salivary gland tumours.28377929
NeoplasmsEpigenetic AlterationsExpression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours.28377929
Colorectal Cancer PathwayEpigenetic AlterationsDNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancer.28378457
Clinical CoordinatorEpigenetic AlterationsWhile BRAF- and KRAS-mutation(+) CRC strongly correlated with HME and IME, respectively, clinicopathological features of NRAS-mutation(+) CRC, including association with DNA methylation, remain unclear.28378457
Von Hippel-Lindau Syndrome, HemangioblastomaEpigenetic AlterationsDifferences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.28379443
VHL protein, humanEpigenetic AlterationsVHL promoter hypermethylation was detected only in sporadic HBs (33%), indicating that epigenetic suppression of VHL is a common mechanism in sporadic HBs.28379443
OsteosarcomaEpigenetic AlterationsMicroRNA-126 Inhibits Proliferation, Migration, Invasion, and EMT in Osteosarcoma by Targeting ZEB1.28379605
Malignant neoplasm of urinary bladderEpigenetic AlterationsWe previously reported on the role of microRNA (miR)-145 as a tumor-suppressor in human bladder cancer (BC) cells.28380435
Liver carcinomaEpigenetic AlterationsLong non-coding RNA colon cancer-associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma progression.28381168
Malignant NeoplasmsEpigenetic AlterationsRecently, long non-coding RNAs have been demonstrated to participate in pathogenesis of many diseases including the progression in several cancers.28381168
Stomach CarcinomaEpigenetic AlterationsEffect of histone modifications on hMLH1 alternative splicing in gastric cancer.28381181
CarcinogenesisEpigenetic AlterationsEpigenetic regulation may play more important roles than gene mutations in DNA damage repair genes to drive carcinogenesis.28381181
Colorectal Cancer PathwayEpigenetic AlterationsExpression of claudin 1, claudin 4, and claudin 7 in colorectal cancer and its relation with CLDN DNA methylation patterns.28381183
NeoplasmsEpigenetic AlterationsTo detect the DNA methylation pattern of CLDN1, 4, and 7, genomic DNA was extracted from both the tumor and the adjacent nonneoplastic mucosa.28381183
Colorectal Cancer PathwayEpigenetic AlterationsHowever, the role of epigenetic modifications in these genes and their role in colorectal cancer is unknown.28381183
Colorectal Cancer Pathway, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression.28381186
Malignant NeoplasmsEpigenetic AlterationsThe plasmacytoma variant translocation 1 gene (PVT1) is a large non-coding locus at adjacent of c-Myc, and long non-coding RNA PVT1 is now recognized as a cancerous gene co-amplified with c-Myc in various cancers.28381186
Squamous cell carcinoma of the head and neckEpigenetic AlterationsUnique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas.28381277
Squamous cell carcinoma of the head and neck, Human papilloma virus infectionEpigenetic AlterationsWe identified a novel epigenetic signature of HPV infection in HNSCCs which is independent of the anatomic site, is functionally correlated with gene expression and may be leveraged for improved stratification of prognosis in HNSCCs.28381277
Steatohepatitis, HyperlipidemiaEpigenetic AlterationsmiRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression.28381526
Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-93 (miR-93) usually acts as a promoter of tumor progression in several human carcinomas.28382439
Corneal dystrophyEpigenetic AlterationsComprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy.28384203
Electron-Capture DissociationEpigenetic AlterationsHere, we report on and compare the DNA methylation landscape of normal human corneal endothelial (CE) tissue and CE from FECD patients using the Illumina Infinium HumanMethylation450 (HM450) DNA methylation array.28384203
Electron-Capture DissociationEpigenetic AlterationsWe show that DNA methylation profiles are distinct between control and FECD samples.28384203
Electron-Capture Dissociation, LossEpigenetic AlterationsOur results suggest that altered DNA methylation patterns may contribute to loss of corneal transparency in FECD through a global accumulation of sporadic DNA methylation changes in genes critical to basic CE biological processes.28384203
Electron-Capture DissociationEpigenetic AlterationsEpigenetic modifications that occur in FECD are unknown.28384203
Admitting diagnosisEpigenetic AlterationsThe interaction between DNA methylation of CpG5 and AA genotype of rs6265 had a risk role in the development of aMCI (p = 0.019, OR = 1.233, 95% CI: 1.117-1.303) and its progression to AD (p = 0.003, OR = 1.399, 95% CI: 1.198-1.477).28387675
Admitting diagnosisEpigenetic AlterationsThe interactions between DNA methylation (CpG5) of the BDNF gene promoter and the tag SNP (rs6265) play important roles in the etiology of aMCI and its conversion to AD.28387675
Admitting diagnosis, "Alzheimers DiseaseEpigenetic AlterationsAlzheimers disease (AD) is a complex multifactorial disease influenced by both genetic and epigenetic factors.28387675
Stomach CarcinomaEpigenetic AlterationsClinicopathological significance of the microRNA-146a/WASP-family verprolin-homologous protein-2 axis in gastric cancer.28387985
DICER1 protein, humanEpigenetic AlterationsDicer and Drosha, which have a role in activation process of miRNA, also act in a double-strand DNA break (DSB) repair mechanism.28388279
Malignant neoplasm of urinary bladderEpigenetic AlterationsCell-free microRNA expression signatures in urine serve as novel noninvasive biomarkers for diagnosis and recurrence prediction of bladder cancer.28388561
Malignant neoplasm of urinary bladderEpigenetic AlterationsUrinary microRNAs (miRNAs) are potential biomarkers for the noninvasive diagnosis of bladder cancer (BC).28388561
Papillary thyroid carcinomaEpigenetic AlterationsMicroRNA-based molecular classification of papillary thyroid carcinoma.28393181
F9 geneEpigenetic AlterationsThese findings provide new insights into the molecular classification of PTC, showing that different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence.28393181
cervical cancerEpigenetic AlterationsMicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer.28393232
cervical cancerEpigenetic AlterationsOver the past decade, an increasing number of studies indicate a central role for microRNAs in the initiation and progression of cervical cancer.28393232
NeoplasmsEpigenetic AlterationsMicroRNA (miRNA) deregulation has recently emerged as an important phenomenon in tumor development and progression, however, the mechanisms remain largely unstudied.28398479
Prostate Cancer PathwayEpigenetic AlterationsClinical significance of miRNA host gene promoter methylation in prostate cancer.28398479
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsMethylation status of particular miRNA host genes as independent variables or in combinations might assist physicians in identifying poor prognosis PCa patients preoperatively.28398479
NeoplasmsEpigenetic AlterationsEpigenetic Regulation of CD133 in Gastrointestinal Stromal Tumors.28398518
Gastrointestinal Stromal TumorsEpigenetic AlterationsOur results strongly suggest epigenetic regulation of CD133 expression by promoter methylation in GISTs.28398518
Malignant Neoplasms, cervical cancerEpigenetic AlterationsThus, besides identifying the deregulated expression of HOX cluster members in HPV16 positive cervical cancer and their association with EMT, our study highlighted the mechanism of HPV16 E7-mediated epigenetic regulation of HOX genes in such cancers, potentially serving as bedrock for functional studies in the future.28402266
Breast Carcinoma, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe MicroRNA miR-210 Is Expressed by Cancer Cells but Also by the Tumor Microenvironment in Triple-Negative Breast Cancer.28402752
Gastrointestinal Stromal TumorsEpigenetic AlterationsMiRNA profiling of gastrointestinal stromal tumors by next-generation sequencing.28402935
malignant disease, Gastrointestinal Stromal TumorsEpigenetic AlterationsThese data reveal a detailed miRNA profile of GIST and highlight new candidates that may be important in the development of malignant disease.28402935
TetranitromethaneEpigenetic AlterationsThe expression of microRNA-203 was progressively lower in relation to the TNM staging and was higher in the patient group in clinical remission.28403349
Colonic NeoplasmsEpigenetic AlterationsThe therapy of colon and rectum tumors based on microRNAs remains under investigation reserving huge potential for future applications and clinical interventions in conjunction with existing therapies.28403349
Carcinogenesis, Human papilloma virus infectionEpigenetic AlterationsWe suggest at least two pathways for penile carcinogenesis, one HPV-independent linked to epigenetic events, probably via p16ink4a inactivation; and another, dependent on HPV infection.28403538
Prostate Cancer PathwayEpigenetic AlterationsGlobal analysis of H3K27me3 as an epigenetic marker in prostate cancer progression.28403887
CarcinogenesisEpigenetic AlterationsOur findings point to epigenetic mark H3K27me3 as an important event in prostate carcinogenesis and progression.28403887
NeoplasmsEpigenetic AlterationsWe hypothesize that DFNA5 promoter methylation can be a valuable epigenetic biomarker, based upon strong indications for its role as tumor suppressor gene and its function in regulated cell death.28404884
Neoplasms, Renal Cell Carcinoma PathwayEpigenetic AlterationsOSR1 is a novel epigenetic silenced tumor suppressor regulating invasion and proliferation in renal cell carcinoma.28404905
Breast CarcinomaEpigenetic AlterationsMicroRNA regulation of progesterone receptor in breast cancer.28404930
Breast CarcinomaEpigenetic AlterationsA significant reciprocal correlation between PR mRNA and the miRNA levels were identified suggesting a role for miR-181a, miR-23a and miR-26b in PR regulation in breast cancer.28404930
Mammary NeoplasmsEpigenetic AlterationsThen, expression levels of these miRNAs were measured in Formalin-Fixed, Paraffin-Embedded (FFPE) samples of 29 ER-positive breast cancer tumors and adjacent normal breast tissues.28404930
Breast CarcinomaEpigenetic AlterationsThe diagnostic and prognostic potential of these miRNAs in breast cancer should be further evaluated.28404930
Colorectal Cancer PathwayEpigenetic AlterationsAberrant levels of circulating microRNAs are potential biomarkers for the early detection of colorectal cancer.28404964
Human papilloma virus infectionEpigenetic AlterationsResults demonstrate significant associations between lncRNA-based clustering and DNA methylation, TP53 mutation, and human papillomavirus infection.28405244
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have emerged as key players in a remarkably variety of biological processes and pathologic conditions, including cancer.28405244
Esophageal carcinomaEpigenetic AlterationsLong non-coding RNA MEG3 induces cell apoptosis in esophageal cancer through endoplasmic reticulum stress.28405686
Fibrosis, LiverEpigenetic AlterationsBased on our recent finding that disruption of bile acid (BA) homeostasis in mice results in the induction of hepatic long noncoding RNA H19 expression, we sought to elucidate the role of H19 in cholestatic liver fibrosis.28407375
Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe performed cytosine methylation sequencing on genetically diverse patients with acute myeloid leukemia (AML) and found leukemic DNA methylation patterning is primarily driven by nonpromoter regulatory elements and CpG shores.28408400
Leukemia, Myelocytic, AcuteEpigenetic AlterationsEpigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.28408400
MICROPHTHALMIA, SYNDROMIC 7Epigenetic AlterationsAMLs with dominant hypermethylation featured greater epigenetic disruption of promoters, whereas those with dominant hypomethylation displayed greater disruption of distal and intronic regions.28408400
MICROPHTHALMIA, SYNDROMIC 7Epigenetic AlterationsNotably, co-occurrence of both mutations resulted in epigenetic antagonism, with most CpGs affected by either mutation alone no longer affected in double-mutant AMLs.28408400
S100A4 protein, humanEpigenetic AlterationsImportantly, this epigenetic antagonism precedes malignant transformation and can be observed in preleukemic LSK cells from Idh2R140Q or Dnmt3aR882H single-mutant and Idh2R140Q/Dnmt3aR882H double-mutant mice.28408400
MICROPHTHALMIA, SYNDROMIC 7, Leukemia, Myelocytic, AcuteEpigenetic AlterationsNotably, IDH/DNMT3A double-mutant AMLs manifested upregulation of a RAS signaling signature and displayed unique sensitivity to MEK inhibition ex vivo as compared with AMLs with either single mutation.Significance: AML is biologically heterogeneous with subtypes characterized by specific genetic and epigenetic abnormalities.28408400
Adenocarcinoma of lung (disorder)Epigenetic AlterationsDevelopment of a novel prognostic signature of long non-coding RNAs in lung adenocarcinoma.28409273
Malignant NeoplasmsEpigenetic AlterationsIncreasing evidence suggests that long non-coding RNAs (lncRNAs) may play a crucial role in many biological processes in a variety of cancers and serve as the basis for many clinical applications including prognostic biomarkers and potential therapeutic targets.28409273
Hollings Cancer CenterEpigenetic AlterationsWe conclude that hsa_circ_0005986 function as microRNA sponge in tumorigenesis and can be used as a novel biomarker for HCC.28410211
Non-Small Cell Lung CarcinomaEpigenetic AlterationsGenetic variants in regulatory regions of some miRNAs might be involved in non-small cell lung cancer susceptibility and survival.28410417
Primary malignant neoplasmEpigenetic AlterationsUNCX expression turned out to be associated, and significantly correlated, with DNA methylation increase at its canyon borders based on data in our patients and in archived data of patients from The Cancer Genome Atlas.28411256
Leukemia, Myelocytic, AcuteEpigenetic AlterationsWe here describe a leukemogenic role of the homeobox gene UNCX, activated by epigenetic modifications in acute myeloid leukemia (AML).28411256
Reduced antigen-specific T cell proliferation, Leukemia, Myelocytic, AcuteEpigenetic AlterationsIn summary, our findings suggest a novel leukemogenic role of UNCX, associated with epigenetic modifications and with impaired cell proliferation and differentiation in AML.28411256
PheochromocytomaEpigenetic AlterationsMicroRNA 183 family profiles in pheochromocytomas are related to clinical parameters and SDHB expression.28412207
Alzheimers DiseaseEpigenetic AlterationsDNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimers disease.28412600
Admitting diagnosisEpigenetic AlterationsLower DNA methylation at TREM2 intron 1 caused higher TREM2 mRNA expression in the leukocytes of AD subjects versus controls and may be a biomarker for AD.28412600
DNA Damage, Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia.28412730
Prostate Cancer PathwayEpigenetic AlterationsGenome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns.28412973
Prostate Cancer PathwayEpigenetic AlterationsDNA methylation is a stable genomic modification that is detectable in peripheral patient fluids such as urine and blood plasma that could serve as a non-invasive diagnostic biomarker for prostate cancer.28412973
Malignant neoplasm of prostateEpigenetic AlterationsWe measured genome-wide DNA methylation patterns in 73 clinically annotated fresh-frozen prostate cancers and 63 benign-adjacent prostate tissues using the Illumina Infinium HumanMethylation450 BeadChip array.28412973
Malignant neoplasm of prostateEpigenetic AlterationsFurthermore, by overlaying ENCODE transcription factor binding data, we observed an enrichment of enhancer of zeste homolog 2 binding in gene regulatory regions with higher DNA methylation in malignant prostate tissues.28412973
Prostate Cancer PathwayEpigenetic AlterationsDNA methylation patterns are greatly altered in prostate cancer tissue in comparison to benign-adjacent tissue.28412973
Prostate Cancer Pathway, Malignant neoplasm of prostateEpigenetic AlterationsWe have discovered patterns of DNA methylation marks that can distinguish prostate cancers with high specificity and sensitivity in multiple patient tissue cohorts, and we have identified transcription factors binding in these differentially methylated regions that may play important roles in prostate cancer development.28412973
Malignant NeoplasmsEpigenetic AlterationsThe long non-coding RNAs (lncRNAs) have been recently shown to participate in the progression of a variety of cancers.28415044
PeripheralEpigenetic AlterationsMicro RNA-98 suppresses interleukin-10 in peripheral B cells in patient post-cardio transplantation.28415669
Secondary malignant neoplasm of liver, Malignant tumor of colonEpigenetic AlterationsExosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer.28415718
Malignant tumor of colonEpigenetic AlterationsWe have profiled 754 miRNAs in 15 colon cancer plasma samples from the tumor-draining vein, the mesenteric vein (MV), identifying 13 microRNAs associated with relapse.28415718
NeoplasmsEpigenetic AlterationsBefore reaching a peripheral vein (PV), miRNAs released by the tumor are diluted and dispersed throughout the body or even retained in a specific organ.28415718
Malignant tumor of colonEpigenetic AlterationsThe prognostic impact of these miRNAs were validated in 50 MV and 50 paired PV plasma samples of stage I-III colon cancer patients.28415718
Malignant tumor of colon, NeoplasmsEpigenetic AlterationsOur results indicate that in colon cancer, the primary tumor releases high concentrations of miRNAs through the MV, and some of them are contained in tumor derived exosomes.28415718
Primary Neoplasm, Colorectal Cancer Pathway, Secondary malignant neoplasm of liverEpigenetic AlterationsDifferential microRNA expression profiling in primary tumors and matched liver metastasis of patients with colorectal cancer.28415758
Secondary malignant neoplasm of liverEpigenetic AlterationsThirteen miRNAs were deregulated in pCRCs compared to their matched liver metastases.28415758
Secondary malignant neoplasm of liverEpigenetic AlterationsSeventeen miRNAs were chosen for validation, which confirmed significantly reduced expression of miR-99b-5p, miR-377 and miR-200c and increased expression of miR-196b-5p in the tissue of liver metastasis.28415758
Secondary malignant neoplasm of liverEpigenetic AlterationsFirstly, affymetrix microarrays involving 1036 miRNAs were performed in two pairs of primary CRCs (pCRCs) and their matched liver metastases.28415758
Clinical CoordinatorEpigenetic AlterationsThese miRNAs may function as prognostic factors in patients with metastatic CRC.28415758
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsDeep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs.28415821
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsWe adopted into RNA-sequencing technologies to construct the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC).28415821
Primary malignant neoplasmEpigenetic AlterationsExpression of miR-150-5p (guide strand miRNA) and miR-150-3p (passenger strand miRNA) were significantly silenced in cancer tissues, suggesting both miRNAs act as antitumor miRNAs in HNSCC cells.28415821
Primary malignant neoplasmEpigenetic AlterationsOur signature revealed that a total of 160 miRNAs (44 upregulated and 116 downregulated) were aberrantly expressed in cancer tissues.28415821
Aggressive behaviorEpigenetic AlterationsEctopic expression of mature miRNAs, miR-150-5p and miR-150-3p inhibited cancer cell aggressiveness.28415821
Chronic Obstructive Airway DiseaseEpigenetic AlterationsDNA methylation profiling in peripheral lung tissues of smokers and patients with COPD.28416970
Comorbidity, Chronic Obstructive Airway DiseaseEpigenetic AlterationsCigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, and comorbidity in the lungs of patients with chronic obstructive pulmonary disease (COPD).28416970
Chronic Obstructive Airway DiseaseEpigenetic AlterationsOur study suggests that DNA methylation in suggestive genes, such as NOS1AP, BID, and GABRB1 may be used as epigenetic signatures in smokers and patients with COPD if the same is validated in a larger cohort.28416970
Colorectal Carcinoma, NeoplasmsEpigenetic AlterationsBrain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor.28418861
Stomach CarcinomaEpigenetic AlterationsEarly detection of gastric cancer using global, genome-wide and IRF4, ELMO1, CLIP4 and MSC DNA methylation in endoscopic biopsies.28418867
Stomach Carcinoma, GastritisEpigenetic AlterationsGlobal, epigenome wide and gene-specific DNA methylation analyses were used in a Phase I Biomarker Development Trial to identify a continuous biomarker panel that combines a Global DNA Methylation Index (GDMI) and promoter DNA methylation levels of IRF4, ELMO1, CLIP4 and MSC.We observed an inverse association between the GDMI and histological progression to gastric cancer, when comparing gastritis patients without metaplasia (mean = 5.74, 95% CI, 4.97-6.50), gastritis patients with metaplasia (mean = 4.81, 95% CI, 3.77-5.84), and gastric cancer cases (mean = 3.38, 95% CI, 2.82-3.94), respectively (p < 0.0001).28418867
Breast CarcinomaEpigenetic AlterationsIn the present study, upon studies of breast cancer cell lines and tissues, we showed that microRNA -196a-3p is decreased by transforming growth factor-b1 in breast cancer cells and associated with breast cancer progression.28418877
Breast CarcinomaEpigenetic AlterationsMoreover, transforming growth factor-b1-mediated inhibition of microRNA -196a-3p and activation of neuropilin-2were required for transforming growth factor-b1-induced migration and invasion of breast cancer cells.28418877
Secondary malignant neoplasm of female breast, Breast CarcinomaEpigenetic AlterationsCollectively, our findings strongly indicate that microRNA -196a-3p is a predictive biomarker of breast cancer metastasis and patient survival and a potential therapeutic target in metastatic breast cancer.28418877
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs are important factors in the development and progression of many malignancies.28418877
Malignant tumor of colonEpigenetic AlterationsOur study is of potential clinical interest because agents that promote or maintain histone acetylation through HDAC inhibition and/or HAT stimulation, may help to lower colon adenoma/carcinoma incidence, especially in high-risk families, or could be included in therapeutic protocols to treat advanced colon cancer.28418886
Acute myocardial infarctionEpigenetic AlterationsExpression pattern of genome-scale long noncoding RNA following acute myocardial infarction in Chinese Uyghur patients.28418905
Fibromatosis, AggressiveEpigenetic AlterationsHuman microRNA expression in sporadic and FAP-associated desmoid tumors and correlation with beta-catenin mutations.28418912
Colorectal Cancer PathwayEpigenetic AlterationsGenetic variation of long non-coding RNA TINCR contribute to the susceptibility and progression of colorectal cancer.28418933
Clinical Coordinator, Histopathologic Grade differentiation, NeoplasmsEpigenetic AlterationsHerein, we explored effect of genetic variants of Tissue differentiation-inducing non-protein coding RNA (TINCR), a key lncRNA required for somatic tissue differentiation and tumor progression, on risk and progression of CRC.28418933
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) serve critical roles in cancer development and progression.28418933
Glioblastoma, NeoplasmsEpigenetic AlterationsThis suggests that non-responding glioblastomas progress chaotically without following distinct gene expression changes while responding tumors adaptively respond or progress by means of the same transcriptional changes.28420326
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHere we tested the hypothesis whether DNA methylation of genes part of the Wnt signaling pathway could help the diagnosis of non-small cell lung cancer (NSCLC).28422739
Neuroblastoma, NeoplasmsEpigenetic AlterationsThese findings highlight the importance of Lamin A/C epigenetic inactivation for a subset of neuroblastomas, leading to enhanced tumour properties and cytoskeletal changes.28422997
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsAlthough PRDM14 is elevated in several cancers, it is unclear if and how PRDM14 confers stem cell-like properties and epigenetic changes to cancer cells.28423353
Primary malignant neoplasmEpigenetic AlterationsHere, we examined the phenotypic characteristics and epigenetic and gene expression profiles of cancer cells that differentially express PRDM14, and assessed the potential of PRDM14-targeted cancer therapy.28423353
MetastasisEpigenetic AlterationsEpigenetic inactivation of the EMT-TFs/miR-34a pathway can potentially alter the equilibrium of these regulations, facilitating EMT and metastasis in BC.28423483
Breast CarcinomaEpigenetic AlterationsMicroRNA-34a targets epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs) and inhibits breast cancer cell migration and invasion.28423483
Neoplasm MetastasisEpigenetic AlterationsMicroRNA-34a (miR-34a) plays an essential role against tumorigenesis and progression of cancer metastasis.28423483
Liver carcinomaEpigenetic AlterationsHistone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma.28423509
Hollings Cancer CenterEpigenetic AlterationsOur data indicate that pharmacological interference of G9a might be a novel epigenetic approach for the treatment of HCC.28423509
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsLong non-coding RNAs, which have been reported in many cancer types, are a potential new class of biomarkers for tumor diagnosis.28423525
Stomach CarcinomaEpigenetic AlterationsThe combination of circulating long noncoding RNAs AK001058, INHBA-AS1, MIR4435-2HG, and CEBPA-AS1 fragments in plasma serve as diagnostic markers for gastric cancer.28423525
Adenocarcinoma of lung (disorder)Epigenetic AlterationsDNA methylation intratumor heterogeneity in localized lung adenocarcinomas.28423542
NeoplasmsEpigenetic AlterationsThis is in contrast to somatic mutations, of which approximately 77% were shared events amongst all regions of individual tumors, suggesting that while the majority of somatic mutations were early clonal events, the tumor-specific DNA methylation might be associated with later branched evolution of these 11 tumors.28423542
NeoplasmsEpigenetic AlterationsFurthermore, our data showed that a higher extent of DNA methylation ITH was associated with larger tumor size (average Euclidean distance of 35.64 (> 3cm, median size) versus 27.24 (<= 3cm), p = 0.014), advanced age (average Euclidean distance of 34.95 (above 65) verse 28.06 (below 65), p = 0.046) and increased risk of postsurgical recurrence (average Euclidean distance of 35.65 (relapsed patients) versus 29.03 (patients without relapsed), p = 0.039).28423542
Colorectal Cancer PathwayEpigenetic AlterationsWe show that the epigenetic age estimated from blood DNA methylation data is statistically significantly associated to future breast and male colorectal cancer development.28423572
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsAcceleration of leukocytes epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer.28423572
Primary malignant neoplasmEpigenetic AlterationsChanges in blood epigenetic age have been associated with several pathological conditions and have recently been described to anticipate cancer development.28423572
Non-Small Cell Lung CarcinomaEpigenetic AlterationsRole of microRNA-21 in radiosensitivity in non-small cell lung cancer cells by targeting PDCD4 gene.28423589
Nasopharyngeal carcinomaEpigenetic AlterationsEpstein-Barr virus encoded microRNA BART7 regulates radiation sensitivity of nasopharyngeal carcinoma.28423621
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsMicroRNAs (miRNAs) play critical roles in hepatocellular carcinoma (HCC) progression and are key determinants of prognosis.28423650
Gastric AdenocarcinomaEpigenetic AlterationsA novel microRNA signature predicts survival in stomach adenocarcinoma.28423653
Malignant NeoplasmsEpigenetic AlterationsRecent microRNA (miRNA) expression profiling studies suggest the clinical use of miRNAs as potential prognostic biomarkers in various malignancies.28423653
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLong non-coding RNA LUCAT1 is associated with poor prognosis in human non-small lung cancer and regulates cell proliferation via epigenetically repressing p21 and p57 expression.28423699
MetastasisEpigenetic AlterationsRecently, long non-coding RNAs (lncRNAs) have been recognized as playing key roles in regulating cellular processes, such as proliferation, invasion, and metastasis.28423699
Malignant neoplasm of breast, NeoplasmsEpigenetic AlterationsWe then determined the genetic relationships between the histologically distinct compartments.Results: In each case, the tumor components have nearly identical landscapes of somatic mutation, implying that the differing histologies do not derive from genetic clonal divergence.Conclusions: A shared origin for tumors with differing histologies suggests that epigenetic or noncoding changes may mediate the metaplastic phenotype and that alternative therapeutic approaches, including epigenetic therapies, may be required for metaplastic breast cancers.28424200
Stomach CarcinomaEpigenetic AlterationsWe found first that miR-128 is down-regulated in gastric cancer cell lines and tissues, and this dysregulation is correlated with DNA methylation and the transcription factor SNAIL.28424413
Thrombocytopenic purpuraEpigenetic AlterationsAltered microRNA (miRNA) expression has been reported in patients with immune thrombocytopenic purpura (ITP).28424819
Thrombocytopenic purpuraEpigenetic AlterationsPlasma microRNAs characterising patients with immune thrombocytopenic purpura.28424819
Glioblastoma Multiforme PathwayEpigenetic AlterationsAccumulating evidence indicates that microRNAs are involved in glioma proliferation, invasion and drug resistance.28425046
Cardiovascular DiseasesEpigenetic AlterationsAltered microRNA expression is implicated in cardiovascular diseases.28425970
AneurysmEpigenetic AlterationsThe data reveal microRNA expression signatures unique to aneurysm location and common to both thoracic and abdominal pathologies.28425970
Vascular calcificationEpigenetic AlterationsAccumulating data suggest that microRNAs (miRs) play an important role in vascular calcification.28426428
malignant diseaseEpigenetic AlterationsChanges in DNA methylation in peripheral blood could be associated with malignant diseases.28426874
Glioblastoma MultiformeEpigenetic AlterationsThis epigenetic silencing is a predictor of response to the alkylating drug temozolomide in glioblastoma.28427088
Primary malignant neoplasmEpigenetic AlterationsInterestingly, DBCCR1 attenuates the expression of DNMT1 (DNA methyltransferase 1), suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation.28427182
Carcinoma of lungEpigenetic AlterationsOur data thus implicates DBCCR1 downregulation as a potential module in the pathogenesis of lung cancer through DNA methylation.28427182
Colorectal Cancer PathwayEpigenetic AlterationsDown-regulation of long non-coding RNA RP11-708H21.4 is associated with poor prognosis for colorectal cancer and promotes tumorigenesis through regulating AKT/mTOR pathway.28427191
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) serve critical roles in cancer development and progression.28427191
Stomach CarcinomaEpigenetic AlterationsMicroRNA-152 regulates immune response via targeting B7-H1 in gastric carcinoma.28427226
Colonic adenomas, Primary malignant neoplasmEpigenetic AlterationsSerum MicroRNA profile in patients with colon adenomas or cancer.28427387
Malignant tumor of colonEpigenetic AlterationsIn these years, circulating microRNAs (miRNAs) have attracted increasing attention as novel biomarkers for colon cancers.28427387
Adenoma, Primary malignant neoplasm, Colonic PolypsEpigenetic AlterationsFive down-regulated miRNAs identified from Cancer versus Normal comparison were included in the list of DEMs identified from Adenomas versus Normal comparison, and may be important for the development of colon polyps and cancer.28427387
Malignant tumor of colon, Colonic adenomasEpigenetic AlterationsWe discovered 8 circulating miRNAs associated with colon adenomas and colon cancer, and these miRNAs may potentially serve as noninvasive screening biomarkers for colon cancer.28427387
Hypertensive (finding), Fibrosis AssessmentEpigenetic AlterationsChronic administration of a DNA methylation inhibitor (ie, 5-Aza-2-deoxycitidine) improved ECG arrhythmic profiles and superoxide dismutase activities and reduced fibrosis in the left ventricle of spontaneously hypertensive rats.28427903
Atrial arrhythmia, Atrial FibrillationEpigenetic AlterationsTaken together, these data support the notion that AF is associated with epigenetic changes in LA and provide a proof-of-concept that hypomethylating agents have to be considered in the treatment of atrial arrhythmias.28427903
Malignant Neoplasms, Metastasis, Primary malignant neoplasmEpigenetic AlterationsIt has been reported that microRNAs (miRNAs) are responsible for acquiring all the hallmarks of cancer cells, as well as have a significant impact on the clinical management of cancers at every stage, including prognosis, remission, relapse, and metastasis.28430523
Cancer TNM FindingEpigenetic AlterationsAltered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients Smoking Status.28430523
Liquid Chromatography, MetastasisEpigenetic AlterationsOur research contributed toward better elucidating the mechanisms underlying the progression of LC as well as the use of miRNAs inhibitors as novel agents against progression and metastasis of LC.28430523
Clinical CoordinatorEpigenetic AlterationsFurthermore, overexpression of long noncoding RNA cardiac hypertrophy-related factor (lncRNA CHRF) was inversely correlated with miR-489 expression in CRC tissues.28430582
NeoplasmsEpigenetic AlterationsmicroRNA-489 (miR-489) is a novel cancer-related miRNAs and functions as a tumor suppressor in human cancers.28430582
SynucleinopathiesEpigenetic AlterationsWe suggest that the regulation of SNCA expression through miRNAs is neuronal-type-specific and possibly plays a part in the phenotypic heterogeneity of synucleinopathies.28431219
NeoplasmsEpigenetic AlterationsWhen comparing GAs by molecular pathway, GAs in tumor tissue were more common for the DNA repair and epigenetic pathways.28431395
Neoplasms, ACTH-Secreting Pituitary AdenomaEpigenetic AlterationsIncreased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crookes cell morphology.28432562
Crooke Cell AdenomaEpigenetic AlterationsIn addition, all four microRNAs from the miR-106b~25 cluster displayed marked upregulation in Crookes cell adenomas.28432562
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsProfiling microRNA from nephrectomy and biopsy specimens: predictors of progression and survival in clear cell renal cell carcinoma.28432832
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsTo identify microRNA (miRNA) characteristic of metastatic clear cell renal cell carcinoma (ccRCC) and those indicative of cancer-specific survival (CSS) in nephrectomy and biopsy specimens.28432832
Intracranial AneurysmEpigenetic AlterationsDNA Methylation Regulates Gene Expression in Intracranial Aneurysms.28433851
Intracranial AneurysmEpigenetic AlterationsIn the development of intracranial aneurysms, DNA methylation plays an important role in the regulation of genetic expression involved in immune and inflammatory reactions, cell function, cell maintenance, and cell signal transduction.28433851
Esophageal carcinomaEpigenetic AlterationsDirect Downregulation of B-Cell Translocation Gene 3 by microRNA-93 Is Required for Desensitizing Esophageal Cancer to Radiotherapy.28434073
Chronic Obstructive Airway DiseaseEpigenetic AlterationsThese data suggest a potential role of epigenetic machinery in mediating the anti-inflammatory effects of exercise in COPD patients.28435027
Chronic Obstructive Airway DiseaseEpigenetic AlterationsThe severity of COPD was attenuated by miR-106b-5p, thus suggesting this miRNA as potential target for disease treatment.28435243
Chronic Obstructive Airway DiseaseEpigenetic AlterationsPeripheral leukocyte microRNAs as novel biomarkers for COPD.28435243
Chronic Obstructive Airway DiseaseEpigenetic AlterationsCompared to healthy controls, 19 differentially expressed miRNAs were found in COPD patients.28435243
Chronic Obstructive Airway DiseaseEpigenetic AlterationsFor all COPD groups, miR-3177-3p was downregulated, while 17 miRNAs were upregulated.28435243
Chronic Obstructive Airway DiseaseEpigenetic AlterationsFurthermore, the results revealed 21 differentially expressed miRNAs, of which miR-183-5p was continually downregulated from A to B to D. Between respective bronchodilator reversibility positive and negative groups of COPD different groups (A, B, C, and D), 10 miRNAs were differentially expressed, while miR-100-5p was upregulated in the negative groups.28435243
Colorectal Cancer Pathway, Malignant neoplasm of esophagus, ibudilast, Inflammatory Bowel DiseasesEpigenetic AlterationsWe also used quantitative reverse transcription PCR to validate the predicted expression levels of miRNAs in three diseases: inflammatory bowel disease (IBD), oesophageal cancer, and colorectal cancer.28436302
CO-methylating acetyl-CoA synthase activity, Acute Coronary SyndromeEpigenetic AlterationsAlthough circulating microRNA (miRNAs) have emerged as biomarkers predicting mortality in acute coronary syndrome (ACS), more data are needed to understand these mechanisms.28437675
CO-methylating acetyl-CoA synthase activityEpigenetic AlterationsMapping miRNAs to high-risk traits may identify miRNAs involved in pathways conferring risk for poor outcome in ACS.28437675
Aortic valve disorderEpigenetic AlterationsThese novel findings indicate that modulation of the epigenetic mechanism underlying valvular pro-osteogenic activity has therapeutic potential for prevention of calcific aortic valve disease progression.28438736
Malignant Neoplasms, Non-Small Cell Lung CarcinomaEpigenetic AlterationsHypermethylation of miRNA-589 promoter leads to upregulation of HDAC5 which promotes malignancy in non-small cell lung cancer.28440397
Metastasis, Liver carcinomaEpigenetic AlterationsMicroRNA-26a inhibits proliferation and metastasis of human hepatocellular carcinoma by regulating DNMT3B-MEG3 axis.28440439
Disease, Primary malignant neoplasmEpigenetic AlterationsAltered microRNA (miRNA) expression has been reported to participate in the pathogenesis of several human diseases, and particularly cancer.28440476
Malignant neoplasm of endometriumEpigenetic AlterationsGenome-wide DNA methylation sequencing reveals miR-663a is a novel epimutation candidate in CIMP-high endometrial cancer.28440489
Malignant NeoplasmsEpigenetic AlterationsAberrant DNA methylation is widely observed in many cancers.28440489
Malignant neoplasm of endometriumEpigenetic AlterationsConcurrent DNA methylation of multiple genes occurs in endometrial cancer and is referred to as the CpG island methylator phenotype (CIMP).28440489
Primary malignant neoplasmEpigenetic AlterationsWe then selected two samples each from CIMP-H and CIMP(-) classes, and analyzed DNA methylation status of both normal (peripheral blood cells: PBCs) and cancer tissues by genome-wide, targeted bisulfite sequencing.28440489
Malignant neoplasm of endometrium, Primary malignant neoplasmEpigenetic AlterationsThis is the first report showing that aberrant DNA methylation of the miR-663a promoter can occur in normal tissue of the cancer patients, suggesting a possible link between this epigenetic abnormality and endometrial cancer.28440489
Endometrial CarcinomaEpigenetic AlterationsThis raises the possibility that the hypermethylation of the miR-663a promoter represents an epimutation associated with the CIMP-H endometrial cancers.28440489
Acute leukemiaEpigenetic AlterationsRelationship between epigenetic changes in Wnt antagonists and acute leukemia.28440495
Colorectal Cancer PathwayEpigenetic AlterationsAccumulating evidence shows that mircroRNAs (miRNAs) play a crucial role in the development of colorectal cancer.28440497
Cerebral Infarction, Subarachnoid Hemorrhage, AneurysmalEpigenetic AlterationsCirculating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage.28442458
Malignant Neoplasms, Carcinoma of lungEpigenetic AlterationsAccumulating evidence indicates that abnormal expression of long non-coding RNAs is associated with tumorigenesis in multiple cancers, including lung cancer.28443464
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-140-5p inhibits cell proliferation and invasion by regulating VEGFA/MMP2 signaling in glioma.28443475
Nasopharyngeal carcinoma, Malignant neoplasm of liverEpigenetic AlterationsLong Noncoding RNA Highly Upregulated in Liver Cancer Activates p53-p21 Pathway and Promotes Nasopharyngeal Carcinoma Cell Growth.28445086
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe HDAC inhibitor valproate induces a bivalent status of the CD20 promoter in CLL patients suggesting distinct epigenetic regulation of CD20 expression in CLL in vivo.28445158
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in the cancer development and progression; overexpression of miR-103 has been identified in various tumors.28445396
Primary malignant neoplasmEpigenetic AlterationsEmerging studies indicated that long non-coding RNAs (lncRNAs) play crucial roles in cancer biology.28445936
Neoplasms, Retinoblastoma, Childhood Medulloblastoma, Glioblastoma Multiforme, Neuroblastoma, cervical cancerEpigenetic AlterationsExpression of this miRNA generally increases with cell differentiation whereas it is downregulated in several types of tumors, such as breast, lung, ovarian, gastric, colon, and cervical cancers, neuroblastoma, medulloblastoma, glioblastoma, and retinoblastoma.28445974
HerpesEpigenetic AlterationsThyroid hormone (TH) has been suggested to control herpes virus gene expression and replication in neurons via epigenetics through its nuclear receptors.28450196
Myeloid neoplasmEpigenetic AlterationsEpigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignancies.28452111
Myeloid LeukemiaEpigenetic AlterationsEpigenetic studies showed that ID4 methylation might be one of the mechanisms silencing ID4 expression in myeloid leukaemia.28452111
Antilymphocyte SerumEpigenetic AlterationsA continued change in miRNA expression persisted during disease progression indicating the potential use of these particular miRNAs as longitudinal biomarkers in ALS.28454844
Neurodegenerative DisordersEpigenetic AlterationsAs regulators of gene expression, microRNAs (miRNAs) are increasingly used for diagnostic and prognostic purposes in various disease states with increasing exploration in neurodegenerative disorders.28454844
Antilymphocyte Serum, Amyotrophic Lateral SclerosisEpigenetic AlterationsSerum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS).28454844
Primary malignant neoplasmEpigenetic AlterationsWe demonstrate that epigenetic regulation of OPRM1 contributes to opioid tolerance in cancer patients, and that targeted gene therapy could treat cancer-induced nociception and opioid tolerance in a mouse cancer model.28456745
cervical cancerEpigenetic AlterationsOur objective was to analyse the influence of (1) methylation within two immunostimulatory CpG motifs within HPV16 E6 and E7 genes around the viral late promoter and their correlation, if any, with expression deregulation of host receptor (TLR9) and DNA methyltransferases (DNMT1, DNMT3A and DNMT3B) and (2) global DNA methylation levels within CpGs of the repetitive Alu sequences, on cervical cancer (CaCx) pathogenesis.28459195
CarcinogenesisEpigenetic AlterationsEpigenetic alterations within human papillomavirus (HPV) and host cellular genomes are known to occur during cervical carcinogenesis.28459195
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsThe long noncoding RNA urothelial carcinoma-associated 1 overexpression as a poor prognostic biomarker in clear cell renal cell carcinoma.28459210
Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNA urothelial carcinoma-associated 1 has previously played important roles in cancer.28459210
Northeast, Esophageal carcinomaEpigenetic AlterationsWe hypothesized that in addition to currently known environmental risk factors for esophageal cancer, genetic and epigenetic factors are also involved in esophageal carcinogenesis in Northeast India.28459370
Esophageal carcinomaEpigenetic AlterationsThis study reveals a synergistic interaction between epigenetic, genetic, and environmental factors and risk of esophageal cancer in this high-incidence region of Northeast India.28459370
Medical Device Material Rupture, Intracranial AneurysmEpigenetic AlterationsWe compared circulating microRNA (miRNA) levels in plasma of patients with intracranial aneurysms (IA) to those of controls as a first step towards finding potential biomarkers for individuals at high risk of IA development and its subsequent rupture.28459827
Intracranial AneurysmEpigenetic AlterationsCirculating microRNAs in patients with intracranial aneurysms.28459827
Malignant Neoplasms, Prostate Cancer PathwayEpigenetic AlterationsChromosome 8q24 has emerged as an important genetic susceptibility region for several cancers, including prostate cancer; however, little is known about the contribution of DNA methylation in this region to risk.28463958
Prostate Cancer PathwayEpigenetic AlterationsAlthough requiring replication, our findings provide some evidence that 8q24 DNA methylation levels may be associated with prostate cancer risk.28463958
Metastasis, Squamous cell carcinoma of esophagusEpigenetic AlterationsGenome-wide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma.28465481
Squamous cell carcinoma of esophagusEpigenetic AlterationsHowever, there are few DNA methylation markers able to predict the presence of LNM in ESCC.28465481
Squamous cell carcinoma of esophagusEpigenetic AlterationsIn this screening, we focused on differentially methylated regions (DMRs) that were associated with LNM of ESCC, as prime candidates for DNA methylation markers.28465481
Squamous cell carcinoma of esophagusEpigenetic AlterationsThese results suggested that HOXB2 and SEPT9 may be useful epigenetic biomarkers for the prediction of the presence of LNM in ESCC.28465481
Adenocarcinoma of pancreasEpigenetic AlterationsEvaluation of Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Adenocarcinoma: miR-196a and miR-210 Could Be Negative and Positive Prognostic Markers, Respectively.28466015
Malignant Pleural MesotheliomaEpigenetic AlterationsmiRNA regulation is important for DNA damage repair and recognition in malignant pleural mesothelioma.28466156
NeoplasmsEpigenetic AlterationsTwenty-four formalin-fixed, paraffin-embedded (FFPE) tumour specimens were subjected to a miRNA expression screening of 800 important miRNAs using digital quantification via the nCounter technique (NanoString).28466156
NeoplasmsEpigenetic AlterationsThe long non-coding RNA urothelial carcinoma-associated 1 is reportedly upregulated and functions as an oncogene in some tumors.28466784
Malignant NeoplasmsEpigenetic AlterationsLong non-coding RNAs have recently emerged as important regulators in the pathogenesis and progression of cancers.28466784
melanomaEpigenetic AlterationsIdentification of plasma microRNAs as new potential biomarkers with high diagnostic power in human cutaneous melanoma.28466785
Carcinoma of lung, Herpes Simplex Infections, Metastasis, NeoplasmsEpigenetic AlterationsA herpes simplex virus type 2-encoded microRNA promotes tumor cell metastasis by targeting suppressor of cytokine signaling 2 in lung cancer.28468588
Carcinoma of lung, Malignant neoplasm of lung, Metastasis, NeoplasmsEpigenetic AlterationsHowever, whether these microRNAs play a role in the metastasis of lung cancers and how these viral microRNAs precisely regulated the tumor biological process in lung cancer bone metastasis remain obscure.28468588
NeoplasmsEpigenetic AlterationsA similar integrative analysis uncovered 40 of 254 differentially expressed genes, which are potentially regulated by DNA methylation in BRAFV600E-positive tumors.28469731
BRAF NP_004324.2:p.V600E, Neoplasms, F9 geneEpigenetic AlterationsDNA methylation loss in non-promoter, poor CGI and enhancer-enriched regions was a significant event in PTC, especially in tumors harboring BRAFV600E.28469731
F9 geneEpigenetic AlterationsThe integrative analysis revealed genes potentially regulated by DNA methylation pointing out potential drivers and biomarkers related to PTC development.28469731
Degenerative polyarthritis, Rheumatoid Arthritis, Right armEpigenetic AlterationsDNA methylation profiling of articular chondrocytes from OA patients, rheumatoid arthritis (RA) patients, and controls was performed, and candidate genes were chosen for validation of gene demethylation status.28470428
Degenerative polyarthritisEpigenetic AlterationsIt is the first time to show that TRAF1, CTGF, and CX3CL1 genes were hypomethylated in OA chondrocytes and have a consistent correlation with mRNA expression, which suggests that epigenetic changes in the methylation status of TRAF1, CTGF, and CX3CL1 contribute to the pathology of OA.28470428
Sjogrens Syndrome", Perceived stress scaleEpigenetic AlterationsWe described earlier a simultaneously increased that the increased expression of miRNA-146a/b was accompanied by an increase in the expression of and TRAF6 and a decrease in the expression of IRAK1 genes in the peripheral mononuclear cells (PBMCs) of patients with primary Sjogrens syndrome (pSS) patients.28470929
Malignant Pleural MesotheliomaEpigenetic AlterationsPlasmatic extracellular vesicle microRNAs in malignant pleural mesothelioma and asbestos-exposed subjects suggest a 2-miRNA signature as potential biomarker of disease.28472171
Malignant Neoplasms, DiseaseEpigenetic AlterationsChanges in miRNA expression have been implicated in several diseases and cancers, including MPM.28472171
Malignant Pleural MesotheliomaEpigenetic AlterationsWe examined if a specific miRNA signature in plasmatic extracellular vesicles (EV) may help to discriminate between malignant pleural mesothelioma patients (MPM) and subjects with Past Asbestos Exposure (PAE).28472171
DiseaseEpigenetic AlterationsTo elucidate lncRNA function in human disease, we have developed a novel network based method (NLCFA) integrating correlations between lncRNA, protein coding genes and noncoding miRNAs.28472271
Stomach CarcinomaEpigenetic AlterationsKnockdown of long non-coding RNA HOXD-AS1 inhibits gastric cancer cell growth via inactivating the JAK2/STAT3 pathway.28475004
NeoplasmsEpigenetic AlterationsLong non-coding RNA HOXD-AS1 (HOXD cluster antisense RNA 1) has been demonstrated to be closely associated with the progression of several tumors.28475004
Malignant NeoplasmsEpigenetic AlterationsColon cancer-associated transcript 1 (CCAT1), a long non-coding RNA (lncRNA), is upregulated and has a vital role in the pathogenesis of numerous cancers.28475287
Hepatitis B, Fibrosis, LiverEpigenetic AlterationsSerum microRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein are useful tools for liquid biopsy of the patients with hepatitis B virus and advanced liver fibrosis.28475652
Right armEpigenetic AlterationsEpigenetic regulation of immune cell types could be critical for the development and maintenance of autoimmune diseases like rheumatoid arthritis (RA).28475762
NeoplasmsEpigenetic AlterationsThis microRNA also induced apoptosis of hepatoma cells and blocked tumor growth in vivo in the chick chorioallantoic membrane model.28476031
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsWe provided strong molecular, cellular and in vivo evidences for the tumor suppressive activities of miR-4510 bringing to the fore the potential value of this microRNA in HCC therapy.28476031
Malignant neoplasm of liver, NeoplasmsEpigenetic AlterationsNew tumor suppressor microRNAs target glypican-3 in human liver cancer.28476031
NeoplasmsEpigenetic AlterationsThese 5 microRNAs were significantly downregulated in tumoral compared to non-tumoral liver and inhibited tumor cell proliferation.28476031
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsEpigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer.28476123
Clinical Coordinator, Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsEpigenetic down regulation of GPER acts as a tumor suppressor in colorectal cancer and its specific activation might be a potential approach for CRC treatment.28476123
Myeloid Leukemia, ChronicEpigenetic AlterationsResearch on the epigenetic regulation mechanism of the PTPN6 gene in advanced chronic myeloid leukaemia.28480959
Myeloid Leukemia, ChronicEpigenetic AlterationsHowever, epigenetic regulation mechanism of the PTPN6 gene in advanced chronic myeloid leukaemia (CML) remains unclear.28480959
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsRecently, miRNAs have been investigated in the most cancer researches which have demonstrated that they have been dysregulated in many cancers.28482669
Breast CarcinomaEpigenetic AlterationsThis study provides evidence that circRNAs are differentially expressed in breast cancer and are important in carcinogenesis because they participate in cancer-related pathways and sequester miRNAs.28484086
Heart failureEpigenetic AlterationsEpigenetic mechanisms, such as microRNA, histone modification, and DNA methylation, are critical for dysregulated gene expression in heart failure (HF).28485796
Malignant neoplasm of stomach stage IVEpigenetic AlterationsMicroRNA-217 suppressed epithelial-to-mesenchymal transition in gastric cancer metastasis through targeting PTPN14.28485805
HyperglycemiaEpigenetic AlterationsThis suggests that consequences of in utero exposure to maternal hyperglycemia extend beyond the fetal development, possibly through epigenetic programming.28486003
Malignant NeoplasmsEpigenetic AlterationsLong noncoding RNAs (lncRNAs) are crucial regulators in many human cancers, yet their potential roles and molecular mechanisms in CRPC are poorly understood.28487115
Metastasis, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsLong noncoding RNAs (lncRNAs) have important roles in the development, invasion, and metastasis of various tumors, including HSCC, but little is known about the role of lncRNAs in cancer radioresistance.28487500
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-1 acts as a tumor suppressor microRNA by inhibiting angiogenesis-related growth factors in human gastric cancer.28493075
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsWe recently reported that miR-1 was one of the most significantly downregulated microRNAs in gastric cancer (GC) patients from The Cancer Genome Atlas microRNA sequencing data.28493075
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMinimal residual disease eradication with epigenetic therapy in core binding factor acute myeloid leukemia.28494506
Atrial Fibrillation, Fibrosis AssessmentEpigenetic AlterationsMicroRNA-21 via Dysregulation of WW Domain-Containing Protein 1 Regulate Atrial Fibrosis in Atrial Fibrillation.28495464
NeoplasmsEpigenetic AlterationsRecent evidence highlights the crucial regulatory roles of long non-coding RNAs (lncRNA) in tumor biology.28495512
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCirculating plasma microRNAs as potential markers to identify EGFR mutation status and to monitor epidermal growth factor receptor-tyrosine kinase inhibitor treatment in patients with advanced non-small cell lung cancer.28496005
Pulmonary arterial hypertensionEpigenetic AlterationsPri-microRNA-124 rs531564 polymorphism minor allele increases the risk of pulmonary artery hypertension by abnormally enhancing proliferation of pulmonary artery smooth muscle cells.28496318
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-15b promotes proliferation and invasion of non-small cell lung carcinoma cells by directly targeting TIMP2.28498424
NeoplasmsEpigenetic AlterationsMicroRNA-15b (miR-15b) plays an important role in tumor development and progression.28498424
Carcinoma of lungEpigenetic AlterationsThen, miRNA-mRNA regulatory network was constructed to identify miRNA candidates associated with lung cancer through integrating gene expression and miRNA-target prediction.28498428
Carcinoma of lungEpigenetic AlterationsFurthermore, the expression levels of miRNA candidates were validated by stem-loop real-time reverse transcription PCR (qRT-PCR) in larger lung cancer population.28498428
Carcinoma of lungEpigenetic AlterationsDifferential expression profiles of microRNAs as potential biomarkers for the early diagnosis of lung cancer.28498428
Primary malignant neoplasmEpigenetic AlterationsTumor-specific microRNAs (miRNAs) seem to be potential biomarkers for the early diagnosis and treatment of cancer.28498428
Carcinoma of lungEpigenetic AlterationsTherefore, there are a set of signature miRNAs which may be promising biomarkers for the early screening of high-risk populations and early diagnosis of lung cancer.28498428
SERPINB3 wt AlleleEpigenetic AlterationsPrognostic significance of altered miRNA expression in whole blood of OSCC patients.28498442
Malignant NeoplasmsEpigenetic AlterationsA cut-off point (COP) for the discrimination between the R-OC and NR-OC groups was calculated and the significance between over/under expression of the miRNAs and the recurrence of malignancy was determined.28498442
Clinical Coordinator, NeoplasmsEpigenetic AlterationsA recent study reported that the levels of miR-944 in recurrent CRC patients were evidently lower than that in non-recurrent cases, suggesting that miR-944 may function as a tumor suppressive miRNA in CRC.28498456
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsDysfunction of microRNAs (miRNAs) is strongly proved to participate in the pathogenesis and tumorigenicity of colorectal cancer (CRC).28498456
Metastasis, Adenocarcinoma of lung (disorder)Epigenetic AlterationsIncreased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma.28498804
Adenocarcinoma, MetastasisEpigenetic AlterationsBoth DNA methylation levels over -423 and -248 CpG sites of the S100A15 gene promoter were decreased in adenocarcinoma patients with distant metastasis, and the former was associated with lower one-year overall survival.28498804
Metastasis, Adenocarcinoma of lung (disorder)Epigenetic AlterationsIncreased S100A15 expression and decreased DNA methylation of its gene promoter region were associated with high metastasis potential and poor outcome in lung adenocarcinoma, probably through triggering CTNNB1 -centered pathways.28498804
Cervical dysplasia, Primary malignant neoplasmEpigenetic AlterationsDiscovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer.28500655
Clinical Coordinator, Colorectal Cancer Pathway, Malignant NeoplasmsEpigenetic AlterationsColorectal cancer (CRC) is one of the most common cancers worldwide and, although the majority of cases are sporadic, its development and progression depends on a range of factors: environmental, genetic and epigenetic.28504867
DamageEpigenetic AlterationsAlthough increasing evidence suggests that estrogen receptor a (ESRa) genetic variation could modify bone damage caused by environmental fluoride exposure, little is known about epigenetic mechanisms in relation to bone changes.28505433
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsMiR-424 functions as a tumor suppressor in glioma cells and is down-regulated by DNA methylation.28508328
Glioblastoma Multiforme PathwayEpigenetic AlterationsIn addition, based on DNA methylation analysis on clinical specimens and cell lines, we found miR-424 promoter CpG island was frequently methylated and correlated with glioma high grades (P = 0.035) and IDH mutation status (P = 0.042).28508328
Malignant Neoplasms, Glioma, Glioblastoma Multiforme PathwayEpigenetic AlterationsGlioma is one of the most lethal malignancies, and increasing reports revealed that microRNAs (miRNAs), a class of small non-coding RNAs, play a critical role in the development and pathology of human gliomas.28508328
Malignant Head and Neck NeoplasmEpigenetic AlterationsLiterature review enabled identification of 10 microRNAs associated with oral and head and neck malignancies.28512746
Allergic asthmaEpigenetic AlterationsIdentification of a plasma miRNA biomarker signature for allergic asthma: A translational approach.28513859
Asthma PathwayEpigenetic AlterationsThus, we suggest that miRNA levels in plasma might have future potential to subphenotype patients with asthma.28513859
Asthma PathwayEpigenetic AlterationsCandidate miRNAs were then validated in a second, independent group of 26 asthma patients and 12 healthy controls.28513859
Allergic asthmaEpigenetic AlterationsDistinct plasma miRNAs are differentially regulated both in murine and in human allergic asthma and were associated with clinical characteristics of patients.28513859
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCirculating microRNAs as novel biomarkers of ALK-positive nonsmall cell lung cancer and predictors of response to crizotinib therapy.28514730
ALK Positive, Non-Small Cell Lung CarcinomaEpigenetic AlterationsPlasma levels of 21 microRNAs were differentially expressed for ALK-positive and ALK-negative NSCLC, including 14 down-regulated and 7 up-regulated microRNAs.28514730
ALK Positive, Non-Small Cell Lung CarcinomaEpigenetic AlterationsCandidate microRNAs in plasma from ALK-positive (n = 41) and ALK-negative NSCLC patients (n = 32) were quantified using real-time reverse transcriptase quantitative polymerase chain reaction.28514730
ALK Positive, Non-Small Cell Lung CarcinomaEpigenetic AlterationsThus, in this preliminary investigation, we identified a potential panel of 3 microRNAs for distinguishing between patients with ALK-positive and ALK-negative NSCLC.28514730
Intervertebral Disc DegenerationEpigenetic AlterationsInflammatory microRNA-194 and -515 attenuate the biosynthesis of chondroitin sulfate during human intervertebral disc degeneration.28514734
Intervertebral disc disorder, Intervertebral Disc DegenerationEpigenetic AlterationsThese findings together demonstrated a vital role of inflammatory stimulated microRNAs in promoting intervertebral disc degeneration by interrupt chondroitin sulfate synthesis, which may provide new insights into the mechanism and therapeutic approaches in IDD.28514734
Hollings Cancer CenterEpigenetic AlterationsAn innovative analytical approach has been adopted to identify Stochastic Epigenetic Mutations (SEMs) in HCC.HCC and peritumoral tissues showed a different epigenetic profile, mainly characterized by loss of DNA methylation in HCC.28514750
Liver carcinomaEpigenetic AlterationsEpigenome-wide association study in hepatocellular carcinoma: Identification of stochastic epigenetic mutations through an innovative statistical approach.28514750
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsHepatocellular carcinoma (HCC) results from accumulation of both genetic and epigenetic alterations.28514750
Clinical CoordinatorEpigenetic AlterationsLevels of 12 epigenetic cf-nucleosome epitopes were measured in the sera of 58 individuals referred for endoscopic screening for CRC.28515797
Liver carcinomaEpigenetic AlterationsMicroRNA-23b functions as an oncogene and activates AKT/GSK3b/b-catenin signaling by targeting ST7L in hepatocellular carcinoma.28518144
Hollings Cancer CenterEpigenetic AlterationsIn the past few years, many microRNAs (miRNAs) have been proved to have important roles in tumorigenesis of HCC.28518144
Vascular calcificationEpigenetic AlterationsCirculating MicroRNA-125b Predicts the Presence and Progression of Uremic Vascular Calcification.28522697
Hyperphosphatemia (disorder)Epigenetic AlterationsWe identified circulating, cell-free microRNAs as potential biomarkers using in vitro VC models in which both rat and human aortic vascular smooth muscle cells were treated with high levels of phosphate to mimic uremic hyperphosphatemia.28522697
ovarian neoplasmEpigenetic AlterationsThese findings suggest that GABRP enhances the aggressive phenotype of ovarian cancer cells, and that the DNA methylation status of the GABRP -963 CpG site may be useful for predicting the metastatic potential in ovarian cancer patients.28524180
ovarian neoplasmEpigenetic AlterationsAberrant epigenetic regulation of GABRP associates with aggressive phenotype of ovarian cancer.28524180
Primary malignant neoplasmEpigenetic AlterationsDetection of Promoter DNA Methylation of APC, DAPK, and GSTP1 Genes in tissue Biopsy and Matched Serum of Advanced-Stage Lung Cancer Patients.28524770
Breast CarcinomaEpigenetic AlterationsDNA methylation mediated silencing of microRNA-874 is a promising diagnosis and prognostic marker in breast cancer.28525377
Breast CarcinomaEpigenetic AlterationsThe DNA methylation status of the miR-874 promoter region in 19 pairs of breast cancer and adjacent normal samples was analyzed with Sequenom EpiTYPER MassArray.28525377
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMicroRNA-874 (miR-874) is downregulated in several human cancers and has been suggested to be a tumor suppressor gene.28525377
Primary malignant neoplasmEpigenetic AlterationsThus, DNA methylation is thought to provide potential biomarkers for assessment of cancer risk in normal mucosa.28533824
Clinical CoordinatorEpigenetic AlterationsDNA methylation levels in SFRP1 and SFRP2 genes in normal crypts were significantly higher in left-side than right-side CRC with an MSS phenotype.28533824
Primary malignant neoplasmEpigenetic AlterationsOur results showed that DNA methylation of SFRP1 and SFRP2 might be useful to predict cancer risk of surrounding normal mucosa.28533824
Hypertensive diseaseEpigenetic AlterationsIn summary, hsa-circ-0005870 may represent a novel biomarker for the diagnosis of hypertension, and hsa-circ-0005870-miRNA-mRNA network may provide potential mechanism for hypertension.28534714
MIRN-5095 microRNA, humanEpigenetic AlterationsThen, we constructed a network of hsa-circ-0005870-targeted miRNAs, including hsa-miR-6807-3p, hsa-miR-5095, hsa-miR-1273g-3p, hsa-miR-5096, hsa-miR-619-5p, and their corresponding mRNAs.28534714
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsAnalysis of our microRNA (miRNA) expression signature in human cancers has shown that guide and passenger strands of pre-miR-150, i.e., miR-150-5p and miR-150-3p, are significantly downregulated in cancer tissues.28534948
CHOANAL ATRESIA, POSTERIOR, Hormone refractory prostate cancer, Primary malignant neoplasmEpigenetic AlterationsNovel approaches to analysis of antitumor miRNA-regulated RNA networks in cancer cells may provide new insights into the pathogenic mechanisms of naive PCa and CRPC.28534948
Prostate Cancer PathwayEpigenetic AlterationsDual strands of pre-miR-150 (miR-150-5p and miR-150-3p) act as antitumor miRNAs targeting SPOCK1 in naive and castration-resistant prostate cancer.28534948
Primary malignant neoplasmEpigenetic AlterationsEctopic expression assays showed that both strands of miRNAs significantly suppressed cancer cell migration and invasion.28534948
CHOANAL ATRESIA, POSTERIOR, Hormone refractory prostate cancerEpigenetic AlterationsTaken together, dual strands of pre-miR-150 (miR-150-5p and miR-150-3p) acted as antitumor miRNAs in naive PCa and CRPC cells.28534948
Pancreatic carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-296 targets AKT2 in pancreatic cancer and functions as a potential tumor suppressor.28534950
Pancreatic carcinoma, Primary malignant neoplasmEpigenetic AlterationsAlthough microRNA-296 (miR-296) has been studied in various types of human cancer, its expression, biological role and mechanism of action in pancreatic cancer remains to be elucidated.28534950
Stomach CarcinomaEpigenetic AlterationsMicroRNA-200c regulates cisplatin resistance by targeting ZEB2 in human gastric cancer cells.28534959
Chronic Obstructive Airway DiseaseEpigenetic AlterationsAltered microRNA (miRNA or miR) expression has been reported in chronic obstructive pulmonary disease (COPD).28534971
Breast Cancer CellEpigenetic AlterationsPrevious studies have suggested that dysregulation of microRNA (miR) -124a is associated with various types of human cancer.28534972
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1.28535543
NeoplasmsEpigenetic AlterationsMicroRNA-181a-5p (miR-181a-5p) acts as a tumor suppressor which can regulate target gene at the posttranscriptional level.28535543
Degenerative polyarthritisEpigenetic AlterationsMicroRNAs are reported to play key roles in regulating the main risk factors for osteoarthritis (OA) chondrogenesis.28537665
Clinical CoordinatorEpigenetic AlterationsThis is the first report of significant combined and interactive effects between dietary factors and polymorphisms in the microRNA binding site of IL13 in CRC and may provide direct guidance on intake of allium vegetable and overnight meals for individuals with specific genetic variants of IL13 to modify their susceptibility to CRC.28537887
Primary malignant neoplasmEpigenetic AlterationsIncreasing evidence supports that microRNA (miRNA)-mediated gene regulation plays a significant functional role in cancer progression.28537888
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer.28538837
NeoplasmsEpigenetic AlterationsMaternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), has tumor-suppressor properties and its expression is lost in several human tumors.28539329
Malignant neoplasm of thyroidEpigenetic AlterationsOverexpression of long intergenic noncoding RNA LINC00312 inhibits the invasion and migration of thyroid cancer cells by down-regulating microRNA-197-3p.28539331
NeoplasmsEpigenetic AlterationsThese microRNAs may serve as potentially early biomarker and act as tumor suppressor genes.28539816
Anxiety, CTCAE 5.0Epigenetic AlterationsEpigenetic regulation in anxiety is suggested, but evidence from large studies is needed.28540928
Breast CarcinomaEpigenetic AlterationsLow Expression of Circulating MicroRNA-34c is Associated with Poor Prognosis in Triple-Negative Breast Cancer.28540980
NeoplasmsEpigenetic AlterationsThe microRNA-34 (miR-34) family is important in tumor regulation.28540980
diabeticEpigenetic AlterationsDifferential DNA methylation of MSI2 and its correlation with diabetic traits.28542303
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentEpigenetic AlterationsDifferential DNA methylation with hyperglycemia is significantly associated with Type 2 Diabetes (T2D).28542303
HyperglycemiaEpigenetic AlterationsHowever, the relevance of the differential DNA methylation changes with hyperglycemia in blood with pancreatic islets remains unclear.28542303
HyperglycemiaEpigenetic AlterationsOur findings suggest that epigenetic perturbation on the target site of MSI2 gene in circulating blood and pancreatic islets should represent or affect hyperglycemia.28542303
Multiple MyelomaEpigenetic AlterationsDeregulated expression of long non-coding RNA UCA1 in multiple myeloma.28543758
Breast CarcinomaEpigenetic AlterationsLong non-coding RNA HOXA-AS2 promotes proliferation and invasion of breast cancer by acting as a miR-520c-3p sponge.28545023
Malignant NeoplasmsEpigenetic AlterationsThe long non-coding RNA (lncRNA) HOXA cluster antisense RNA2 (HOXA-AS2) has recently been shown to be dysregulated and involved in the progression of several cancers.28545023
Papillary thyroid carcinomaEpigenetic AlterationsIdentification of novel long non-coding RNA biomarkers for prognosis prediction of papillary thyroid cancer.28545026
Non-Malignant Nodule, Pathological accumulation of air in tissuesEpigenetic AlterationsAge, smoking status, nodule diameter, history of emphysema, vascular sign, burr sign, CYFRA21-1, CEA, miRNA-21-5p, and miRNA-574-5p differed significantly between the benign and malignant nodule groups.28545454
Graves Disease, Atrial FibrillationEpigenetic AlterationsCirculating microRNA-1a is a biomarker of Graves disease patients with atrial fibrillation.28547036
Atrial FibrillationEpigenetic AlterationsIt has been increasingly suggested that specific microRNAs expression profiles in the circulation and atrial tissue are associated with the susceptibility to atrial fibrillation.28547036
Atrial Fibrillation, Graves DiseaseEpigenetic AlterationsThe expression profiles of eight serum microRNAs, which are found to be critical in the pathogenesis of atrial fibrillation, were determined in patients with Graves disease with or without atrial fibrillation.28547036
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsInfrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype.28548123
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsWe have previously shown that commonly expressed miRNAs influenced tumor molecular phenotype in colorectal cancer.28548123
NeoplasmsEpigenetic AlterationsWe hypothesize that infrequently expressed miRNAs, when showing higher levels of expression, help to define tumor molecular phenotype.28548123
NeoplasmsEpigenetic AlterationsWe compare miRNAs uniquely associated with tumor molecular phenotype to the RNAseq data to identify genes associated with these miRNAs.28548123
NeoplasmsEpigenetic AlterationsOf the 34 miRNAs associated with CpG island methylator phenotype-high tumors, 16 were more likely to have a CpG island methylator phenotype-high tumor and 19 were less likely to be CpG island methylator phenotype-high.28548123
NeoplasmsEpigenetic AlterationsFor microsatellite instability, 13 of the 22 infrequently expressed miRNAs were significantly less likely to be expressed in microsatellite unstable tumors.28548123
NeoplasmsEpigenetic AlterationsOf the dysregulated miRNAs, 17 were more likely to be TP53-mutated tumors while simultaneously being less likely to be CpG island methylator phenotype-high and/or microsatellite instability tumors.28548123
Primary malignant neoplasmEpigenetic AlterationsGenes regulated by these miRNAs were involved in numerous functions and pathways that influence cancer risk and progression.28548123
NeoplasmsEpigenetic AlterationsIn summary, some infrequently expressed miRNAs, when expressed at higher levels, appear to have significant biological meaning in terms of tumor molecular phenotype and gene expression profiles.28548123
Malignant tumor of colonEpigenetic AlterationsMicroRNA-186-5p overexpression modulates colon cancer growth by repressing the expression of the FAM134B tumour inhibitor.28549913
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsSeveral miRNAs have been reported to be associated with PCa.28551819
Malignant tumor of colonEpigenetic AlterationsMicroRNA-200b is downregulated in colon cancer budding cells.28552992
Coronary Artery DiseaseEpigenetic AlterationsAssociation between circulating microRNA-208a and severity of coronary heart disease.28554251
MyocardiumEpigenetic AlterationsCirculating microRNA (miR)-208a is specifically expressed in the heart muscle, which is involved in the regulation of myosin during cardiac development.28554251
Choline Dehydrogenase, MitochondrialEpigenetic AlterationsCHD patients had higher miRNA-208a expression (1.61, 0.45-3.86 vs. 0.66, 0.11-1.42, p < .001), and the biomarker level significantly increased following an increasing the Gensini score (p < .001).28554251
Rectal CarcinomaEpigenetic AlterationsChanges of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy.28554991
Primary malignant neoplasmEpigenetic AlterationsCirculating microRNAs are promising candidates, however analyses of circulating microRNAs in rectal cancer are still rare.28554991
Carcinogenesis, Helicobacter pyloriEpigenetic AlterationsResidual DNA methylation in the gastric mucosa after Helicobacter pylori (H. pylori) eradication may have a role in gastric carcinogenesis.28557342
Intestinal metaplasiaEpigenetic AlterationsThe atrophic type by the magnifying NBI and presence of intestinal metaplasia are the morphologic characteristics of residual DNA methylation of after H. pylori eradication, regardless of the post-eradication period and it might be considered as the epigenetic irreversible point with H. pylori eradication.28557342
NeoplasmsEpigenetic AlterationsSpecifically, localised and systemic biochemical alterations produced during and following exercise may suppress tumour formation, growth and distribution by virtue of altered epigenetics and endocrine-paracrine activity.28559456
Prostate Cancer PathwayEpigenetic AlterationsEffects of genistein supplementation on genome-wide DNA methylation and gene expression in patients with localized prostate cancer.28560383
Liver carcinomaEpigenetic AlterationsMicroRNA-526a targets p21-activated kinase 7 to inhibit tumorigenesis in hepatocellular carcinoma.28560394
Plaque, AtheroscleroticEpigenetic AlterationsmicroRNAs (miRNAs) serve significant roles in the pathophysiology of atherosclerotic plaque progression.28560417
Malignant Neoplasms, CarcinogenesisEpigenetic AlterationsMicroRNAs are a class of small noncoding RNA molecules, which play important roles in diverse biological processes of human cancers, such as carcinogenesis, development, differentiation, and apoptosis.28560419
Breast Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer.28562349
Breast CarcinomaEpigenetic AlterationsMicroRNA (miR)-155 is upregulated in breast cancer cells and in sera of patients with breast cancer, but its clinical relevance remains uncertain.28562349
Stomach CarcinomaEpigenetic AlterationsThe significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer.28562634
Hepatobiliary Disorder, Hepatitis, ChronicEpigenetic AlterationsCirculating microRNA as a marker for predicting liver disease progression in patients with chronic hepatitis B.28562750
Complete atrioventricular blockEpigenetic AlterationsWe compared microRNA expression profiles between CHB with and without cirrhosis/HCC to discover possible prognostic markers associated with the progression of CHB.28562750
Complete atrioventricular blockEpigenetic AlterationsOur results indicated 8 differently expressed microRNAs, of which miRNA-935, miRNA-342, miRNA-339, miRNA-4508, miRNA-3615, and miRNA-3200 were up-regulated, whereas miRNA-182 and miRNA-4485 were down-regulated in patients with CHB who progressed to cirrhosis/HCC as compared to those without progression.28562750
Liver Cirrhosis, Hollings Cancer CenterEpigenetic AlterationsThese miRNAs may serve as novel and non-invasive prognostic markers for early detection of CHB-infected patients who are at risk of progression to cirrhosis and/or HCC.28562750
Stomach CarcinomaEpigenetic AlterationsLong noncoding RNA UCA1 induced by SP1 promotes cell proliferation via recruiting EZH2 and activating AKT pathway in gastric cancer.28569779
Malignant Neoplasms, InitiationEpigenetic AlterationsLong noncoding RNA UCA1 has emerged as a novel regulator in cancer initiation and progression of various cancers.28569779
Diabetic Retinopathy, Vitreous humorEpigenetic AlterationsMicroRNA-200b Expression in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy.28571008
PDR geneEpigenetic AlterationsmiRNA-200b expression was about 5-fold increased in the vitreous samples from eyes with PDR compared with the controls (p <= 0.001).28571008
PDR gene, stress-induced mitochondrial fusionEpigenetic AlterationsVitreous VEGF expression was also significantly higher in the PDR group than in the IMH group (p <= 0.001), but no significant correlation was found between miRNA-200b and VEGF.28571008
PDR geneEpigenetic AlterationsBoth miRNA-200b and VEGF are increased in the vitreous of patients with PDR but in a noncorrelated pattern.28571008
PDR geneEpigenetic AlterationsmiRNA-200b may be involved in the pathogenesis of PDR but through VEGF-independent mechanisms.28571008
Prostate Cancer PathwayEpigenetic AlterationsPlasma microRNA signature is associated with risk stratification in prostate cancer patients.28571116
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsWe identified 27 up- and 2 downregulated plasma miRNAs in PCa patients compared with healthy men.28571116
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThese miRNAs may be promising therapeutic targets for high-risk PCa stratification.28571116
Chronic Lymphocytic LeukemiaEpigenetic AlterationsGenome-wide DNA methylation profiling integrated with gene expression profiling identifies PAX9 as a novel prognostic marker in chronic lymphocytic leukemia.28572861
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe integration of DNA methylation profile (n = 14) with the gene expression profile (n = 21) revealed 142 genes as hypermethylated-downregulated and; 62 genes as hypomethylated-upregulated in early stage CLL patients compared to CD19+ B-cells from healthy individuals.28572861
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThe DNA methylation changes associated with mRNA expression of CRY1 and PAX9 genes allow risk stratification of early stage CLL patients.28572861
Chronic Lymphocytic LeukemiaEpigenetic AlterationsThis comprehensive analysis supports the concept that the epigenetic changes along with the altered expression of genes have the potential to predict clinical outcome in early stage CLL patients.28572861
Communicable Diseases, Malignant neoplasm of mouthEpigenetic AlterationsAlthough epigenetic alterations, such as aberrant DNA methylation, are known to contribute to the pathogenesis of oral cancer, the relationship of such alterations with EBV infection is little known.28573642
Communicable DiseasesEpigenetic AlterationsThese results indicate that epigenetic changes frequently occur in OSCCs and may partly be induced by EBV infection, therefore, EBV may involve in development and progression of the OSCCs.28573642
Transitional cell carcinoma of bladderEpigenetic AlterationsIncreased expression of long non-coding RNA CCEPR is associated with poor prognosis and promotes tumorigenesis in urothelial bladder carcinoma.28574830
NeoplasmsEpigenetic AlterationsRecent emerging evidences have showed that long non-coding RNAs play important regulatory roles in diverse biological processes of tumor development and progression.28574830
Primary malignant neoplasmEpigenetic AlterationsGenetic variations in miRNA binding domains influence the susceptibility to several diseases such as cancer.28578017
melanoma, NeoplasmsEpigenetic AlterationsWe identified and validated biomarkers for, and pathways involved in, melanoma development (e.g., HOXA9 DNA methylation) and tumor progression (e.g., TBC1D16 DNA methylation).28578692
NeoplasmsEpigenetic AlterationsIn addition, we determined a prognostic signature with potential clinical applicability and validated PON3 DNA methylation and OVOL1 protein expression as biomarkers with prognostic information independent of tumor thickness and ulceration.28578692
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsGenome-scale identification of microRNA-related SNPs associated with risk of head and neck squamous cell carcinoma.28582492
Primary malignant neoplasmEpigenetic AlterationsPolymorphisms in microRNAs and their target sites can disrupt microRNA-dependent gene regulation, and have been associated with cancer susceptibility.28582492
Squamous cell carcinoma of the head and neck, Primary malignant neoplasmEpigenetic AlterationsThese results suggest microRNA-related genetic variation may contribute to the genetic susceptibility of HNSCC, and that more powerful evaluation of this class of genetic variation and their relationship with cancer risk is warranted.28582492
DysplasiaEpigenetic AlterationsAlso, we found that gastric epithelium cells lose the TMEPAI expression concurrently with severe dysplasia progression, which probably caused by a mechanism involving specific microRNA.28584893
NeoplasmsEpigenetic AlterationsIn conclusion, these data provided evidence that epigenetic regulation of PTPRO impairs its tumor suppressor role in LSCC, and restoration of PTPRO may be a potential therapeutic strategy.28586036
Cubital Tunnel SyndromeEpigenetic AlterationsDifferential expression of miRNAs in Osbornes ligament of cubital tunnel syndrome.28586055
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-148a suppresses epithelial-mesenchymal transition and invasion of pancreatic cancer cells by targeting Wnt10b and inhibiting the Wnt/b-catenin signaling pathway.28586066
HumorEpigenetic AlterationsMicroRNAs (miRNAs) are small, endogenous noncoding RNAs that have been detected in human aqueous humor (AH).28586912
NeoplasmsEpigenetic AlterationsMicroRNA-16-5p Inhibits Osteoclastogenesis in Giant Cell Tumor of Bone.28589137
Malignant neoplasm of urinary bladderEpigenetic AlterationsIdentification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer.28589857
Primary malignant neoplasmEpigenetic AlterationsThrough transcriptional silencing of critical cancer-related genes, epigenetic change such as DNA methylation plays a crucial role in cancer.28589857
Primary malignant neoplasmEpigenetic AlterationsHowever, a mechanistic role of synergistic interactions between DNA methylation and miRNA as epigenetic regulators on transcriptomic changes and its association with clinical outcomes such as survival have remained largely unexplored in cancer.28589857
METRNL geneEpigenetic AlterationsThen, 11 significant epigenetic interactions between miRNA and methylation, which target E2F3, CCND1, UTP6, CDADC1, SLC35E3, METRNL, TPCN2, NACC2, VGLL4, and PTEN, were found to be associated with survival.28589857
Malignant neoplasm of urinary bladderEpigenetic AlterationsTo this end, exploration of TCGA bladder cancer data identified epigenetic interactions that are associated with survival as potential prognostic markers in bladder cancer.28589857
Malignant neoplasm of urinary bladderEpigenetic AlterationsGiven the importance and prevalence of these interactions of epigenetic events in bladder cancer it is timely to understand further how different epigenetic components interact and influence each other.28589857
NeoplasmsEpigenetic AlterationsIn two tumors with 12q rearrangements, RPSAP52 on 12q14.3 was fused with non-coding RNA (accession number XR_944195) from 14q32.2 or ZFP36L1 from14q24.1.28591699
Dysplasia, Fibrosis AssessmentEpigenetic AlterationsConclusions: De novo JAK2mut AML is rare and frequently found in patients with dysplasia, BM fibrosis, and abnormal karyotype with intermediate- or high-risk features; gene mutations in DNA methylation and epigenetic-modifying pathways; and absence of gene mutations in activating signaling pathways.28596259
Stomach CarcinomaEpigenetic AlterationsPolymorphisms of microRNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer.28596683
MEN1 wt Allele, DeficiencyEpigenetic AlterationsMEN1 mutations and potentially MEN1-targeting miRNAs are responsible for menin deficiency in sporadic and MEN1 syndrome-associated primary hyperparathyroidism.28597079
MEN1 wt AlleleEpigenetic AlterationsIn silico target prediction was used to identify miRNAs potentially targeting MEN1.28597079
Malignant NeoplasmsEpigenetic AlterationsA long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-b (lncRNA-ATB) has been recently shown to promote the invasion-metastasis cascade in various types of cancers via upregulation of some targets including ZEB1.28598827
Malignant NeoplasmsEpigenetic AlterationsImpaired miRNAs processing pathway is one interesting scenario for global downregulation of the miRNAome in various types of malignancy.28598829
Multiple MyelomaEpigenetic AlterationsTwo serum microRNAs, miRNA-720 and miRNA-1246, were found to have potential as diagnostic biomarkers in myeloma.28601493
InitiationEpigenetic AlterationsInvolvement of microRNAs has been demonstrated in cancer initiation and progression.28602785
Malignant Neoplasms, Nodular thyroid diseaseEpigenetic AlterationsIt has recently been demonstrated that the combination of miRNA-190 and -95 (expressed as probability of malignant risk: pmiRNA) in the serum of Caucasian patients with thyroid nodular disease allows the identification of nodules at high risk of malignancy with great accuracy.28605303
Metastasis, Liver carcinomaEpigenetic AlterationsMicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway.28606154
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsIncreasing evidences demonstrate that miRNAs contribute to development and progression of hepatocellular carcinoma (HCC).28606154
Primary malignant neoplasmEpigenetic AlterationsEvaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non-Small Cell Lung Cancer Using Next-Generation Sequencing.28606918
Non-Small Cell Lung CarcinomaEpigenetic AlterationsExosomal miRNA profiling of 46 stage I NSCLC patients and 42 healthy individuals was performed using miRNA-seq to identify and validate adenocarcinoma- and SCC-specific miRNAs.28606918
Adenocarcinoma, SERPINB3 wt AlleleEpigenetic AlterationsThe diagnostic accuracy of select miRNAs was tested further with an additional 60 individuals.Results: There were 11 and 6 miRNAs expressed at remarkably higher levels, 13 and 8 miRNAs expressed at lower levels in adenocarcinoma and SCC patients, respectively, compared with healthy volunteers.28606918
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese miRNAs may be promising and effective candidates in the development of highly sensitive, noninvasive biomarkers for early NSCLC diagnosis.28606918
Colorectal Cancer PathwayEpigenetic AlterationsAssociation between genetic variants in the promoter region of a novel antisense long noncoding RNA RP11-392P7.6 and colorectal cancer risk.28612367
Primary malignant neoplasmEpigenetic AlterationsEctopic expression of mature miRNA demonstrated that all members of the miR-199 family inhibited cancer cell migration and invasion by HNSCC cell lines (SAS and HSC3).28612520
Primary malignant neoplasmEpigenetic AlterationsThese findings suggested that both passenger strands and guide strands of miRNA are involved in cancer pathogenesis.28612520
Carcinoma of lungEpigenetic AlterationsOct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression.28615056
Malignant Head and Neck NeoplasmEpigenetic AlterationsEpigenetic silencing of SALL3 is an independent predictor of poor survival in head and neck cancer.28616099
Tongue CarcinomaEpigenetic AlterationsFor qPCR of miR-183 and miR-21 expression, total RNA isolated from 60 fresh-frozen tissue of tongue carcinomas was converted into cDNA by TaqMan MicroRNA Reverse Transcription Kit and quantified by TaqMan MicroRNAs Expression Assays.28616749
cervical cancerEpigenetic AlterationsExpression of microRNA-142-3p in cervical cancer and its correlation with prognosis.28617557
Prostate Cancer Pathway, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsIncreasing evidence suggests that circulating miRNAs in serum and urine may be potential non-invasive biomarkers for prostate cancer (PCa).28617988
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsIn serum EVs, four miRNAs were significantly higher in patients with PCa than with BPH.28617988
Cardiovascular DiseasesEpigenetic AlterationsMany circulating microRNAs (miRs) have been shown to have potential biomarker effects in cardiovascular disease.28618405
Cardiovascular DiseasesEpigenetic AlterationsMicroRNA are noncoding RNA that have a significant role in both inflammatory and cardiovascular diseases.28618412
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsFailed Downregulation of Circulating MicroRNA-155 in the Early Phase after ST Elevation Myocardial Infarction Is Associated with Adverse Left Ventricular Remodeling.28618412
Adenocarcinoma of lung (disorder)Epigenetic AlterationsPrognostic Significance of microRNA-7 and its Roles in the Regulation of Cisplatin Resistance in Lung Adenocarcinoma.28618418
Malignant Neoplasms, Adenocarcinoma of lung (disorder), NeoplasmsEpigenetic AlterationsPreviously, microRNA (miR)-7 has been reported to function as a tumor suppressor in human cancers, but the correlations of miR-7 expression with prognosis and cisplatin (CDDP) resistance in lung adenocarcinoma (LA) are unclear.28618418
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA MSTO2P promotes the proliferation and colony formation in gastric cancer by indirectly regulating miR-335 expression.28618927
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA misato family member 2, pseudogene influenced biologic functions in gastric cancer cells via indirectly regulating the activation of miR-335.28618927
Stomach CarcinomaEpigenetic AlterationsTherefore, long non-coding RNAs might function as key regulatory hubs in gastric cancer progression.28618927
Colorectal Cancer PathwayEpigenetic AlterationsHigh expression of long non-coding RNA ZEB1-AS1 promotes colorectal cancer cell proliferation partially by suppressing p15 expression.28618933
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer.28618943
Stomach CarcinomaEpigenetic AlterationsTaken together, our findings suggest that the long non-coding RNA differentiation antagonizing non-protein coding RNA promotes the proliferation of gastric cancer and is a potential prognostic biomarker and therapeutic target in gastric cancer.28618943
Stomach CarcinomaEpigenetic AlterationsExperiments revealed that silencing differentiation antagonizing non-protein coding RNA significantly inhibited gastric cancer cell proliferation in vitro and in vivo.28618943
Stomach CarcinomaEpigenetic AlterationsOverexpression of differentiation antagonizing non-protein coding RNA notably increases gastric cancer cell proliferation.28618943
Stomach CarcinomaEpigenetic AlterationsRecent evidence indicates that long non-coding RNAs play crucial roles in development and progression of gastric cancer.28618943
Colorectal Cancer PathwayEpigenetic AlterationsDysregulation in microRNA expression is a common feature in colorectal cancer.28618945
Esophageal carcinomaEpigenetic AlterationsDecreased expression of MGMT in correlation with aberrant DNA methylation in esophageal cancer patients from North India.28621225
Liver carcinomaEpigenetic AlterationsLong non-coding RNA CASC2 regulates cell biological behaviour through the MAPK signalling pathway in hepatocellular carcinoma.28621238
Malignant neoplasm of endometrium, Glioma, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsThe long non-coding RNA CASC2 (cancer susceptibility candidate 2) has been characterised as a tumour suppressor in endometrial cancer and gliomas.28621238
Disease, Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs have previously been demonstrated to play important roles in regulating human diseases, especially cancer.28621238
Triple-Negative Breast Cancer FindingEpigenetic AlterationsA microRNA signature associated with pathological complete response to novel neoadjuvant therapy regimen in triple-negative breast cancer.28621239
Breast CarcinomaEpigenetic AlterationsIn summary, we identified a novel microRNA expression signature associated with pathological complete response in breast cancer.28621239
Breast CarcinomaEpigenetic AlterationsMicroRNAs are known biomarkers of breast cancer progression; nevertheless, their potential to identify patients with pathological complete response remains poorly understood.28621239
Verrucous carcinomaEpigenetic AlterationsResearch on miRNA-195 and target gene CDK6 in oral verrucous carcinoma.28621315
SERPINB3 wt AlleleEpigenetic AlterationsThe expression of miRNA from OVC and OSCC including their matched normal oral mucosa tissues was profiled through the Affymetrix GeneChip miRNA Arrays.28621315
SERPINB3 wt AlleleEpigenetic AlterationsIn addition, miRNA-195 was significantly decreased in both OVC and OSCC compared to normal oral mucosa.28621315
SERPINB3 wt AlleleEpigenetic AlterationsCDK6 was increased in OVC and OSCC, which was opposite to the expression of miRNA-195.28621315
SERPINB3 wt AlleleEpigenetic AlterationsMoreover, 44 miRNAs were differentially expressed between OSCC and OVC.28621315
Squamous cell carcinoma of esophagusEpigenetic AlterationsPlasma microRNA-19a as a potential biomarker for esophageal squamous cell carcinoma diagnosis and prognosis.28621611
Primary malignant neoplasmEpigenetic AlterationsThe antisense noncoding RNA in the INK4 locus codes for a long noncoding RNA whose participation in cancer has been elucidated.28621612
Prostate Cancer PathwayEpigenetic AlterationsA Panel of MicroRNAs as Diagnostic Biomarkers for the Identification of Prostate Cancer.28621736
Rheumatic disease of heart valveEpigenetic AlterationsDNA methylation dysregulations in rheumatic heart valve disease.28623907
Rheumatic disease of heart valveEpigenetic AlterationsThe epigenetic changes underlying the development of rheumatic heart valve disease (RHVD) remain incompletely understood.28623907
SteatohepatitisEpigenetic AlterationsDNA methylation at SLC7A11 was associated with reduced risk of hepatic steatosis in participants (odds ratio, 0.69; 95% CI= 0.55-0.93; P value: 2.7 x 10-3).28624579
Fatty degenerationEpigenetic AlterationsOur results provide new insights into epigenetic mechanisms associated with markers of liver function and hepatic steatosis, laying the groundwork for future diagnostic and therapeutic applications.28624579
Metastasis, NeoplasmsEpigenetic AlterationsWe considered genome-wide mRNA and miRNA expression and mutation status of 20 genes assayed in 150 fresh-frozen tumours with known metastasis status.28624625
Gallbladder CarcinomaEpigenetic AlterationsLong non-coding RNA UCA1 promotes gallbladder cancer progression by epigenetically repressing p21 and E-cadherin expression.28624787
Medical Device Material RuptureEpigenetic AlterationsOut of 24 miRNAs selected for replication, 6 miRNAs remained significantly associated with plaque rupture.28624816
Medical Device Material RuptureEpigenetic AlterationsIn the validation phase, combinations of miR-483-5p and miR-451a showed the highest area under the receiver-operating-characteristic curve (AUC) (0.982; CI: 0.907-0.999) in patients with plaque rupture for 0.5 h; combinations of miR-483-5p and miR-155-5p showed the highest AUC (0.898; CI: 0.790-0.962) after plaque rupture for 1 h. In conclusion, using a profiling-replication-validation model, we identified 3 miRNAs including miR-155-5p, miR-483-5p and miR-451a, which may be biomarkers for the early identification of plaque rupture.28624816
ABCB1 wt Allele, Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsWe hypothesize that selected genetic and/or epigenetic changes associated with advanced tumours may help identifying early non-small cell lung cancers (NSCLCs) that recur after resection.28625654
Hypomethylation, Carcinogenesis, Primary malignant neoplasmEpigenetic AlterationsAmong epigenetic changes, long interspersed nuclear element-1 (LINE-1) hypomethylation is seen early during carcinogenesis and may act in concert with genetic alterations to cancer progression.28625654
Carcinogenesis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsGenetic and epigenetic events occurring in early carcinogenesis may help identifying stage I NSCLC patients who deserve adjuvant therapy.28625654
Rheumatoid Arthritis, Right armEpigenetic AlterationsAlterations of miRNAs in rheumatoid arthritis (RA) have been reported, however, the components of the RNAi machinery in RA remain to be fully elucidated.28627619
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsmicroRNA-205 acts as a tumor suppressor and directly targets YAP1 in glioma.28627687
Glioblastoma Multiforme PathwayEpigenetic AlterationsIt is well-established that microRNAs (miRs) are associated with the regulation of glioma initiation and progression, and may represent a novel effective therapeutic strategy for the treatment of glioma.28627687
Stomach Carcinoma, MetastasisEpigenetic AlterationsMicroRNA-508-5p suppresses metastasis in human gastric cancer by targeting S-phase kinase-associated protein 2.28627698
Prostate Cancer PathwayEpigenetic AlterationsHeterogeneity of miRNA expression in localized prostate cancer with clinicopathological correlations.28628624
NeoplasmsEpigenetic AlterationsHowever, tumor heterogeneity may influence miRNA expression.28628624
Prostatic Hyperplasia, CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsFour miRNAs (miRNA-21, miRNA-34a, miRNA-125, and miRNA-126) were significantly upregulated in PCa compared to benign prostatic hyperplasia (BPH), and except for miRNA-21 these miRNAs documented a positive correlation between the expression level in PCa cores and their matched BPH cores, (r > 0.72).28628624
NeoplasmsEpigenetic AlterationsThe results, however, document intra-tumoral heterogeneity in the expression of various miRNAs calling for caution when using these tumor tissue biomarkers in prognostic and predictive settings.28628624
NeoplasmsEpigenetic AlterationsTogether, these data suggest that tumor suppressor microRNAs contribute to the regulation of PD-L1 expression in MPM.28629895
HypoxiaEpigenetic AlterationsLong noncoding RNA H19 is repressed after birth, but can be induced by hypoxia.28630232
Prostate Cancer PathwayEpigenetic AlterationsInhibition of microRNA-500 has anti-cancer effect through its conditional downstream target of TFPI in human prostate cancer.28631332
Uterine Cervical NeoplasmEpigenetic AlterationsGenetic and epigenetic alterations affecting PARK-2 expression in cervical neoplasm among North Indian patients.28631565
Primary malignant neoplasmEpigenetic AlterationsAbnormal expression of microRNAs has been reported to regulate gene expression and cancer cell growth, invasion, and migration.28631567
Nasopharyngeal carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA 183 (miR-183) was identified to be downregulated in nasopharyngeal carcinoma spheroids and served as a tumor suppressor in nasopharyngeal carcinoma.28631568
Hidradenitis SuppurativaEpigenetic AlterationsThe microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: a significant dysregulation within active inflammatory lesions.28634830
Hidradenitis SuppurativaEpigenetic AlterationsRecently, we could show that the expression levels of the key regulators of the microRNA (miRNA) maturation and transport were dysregulated in inflamed hidradenitis suppurativa (HS) tissue (Heyam et al.28634830
Breast Carcinoma, Neoplasm MetastasisEpigenetic AlterationsMicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer.28637482
Primary malignant neoplasm, Neoplasm MetastasisEpigenetic AlterationsMembers of the microRNA (miR)-200 family, which are involved in tumor metastasis, have potential as cancer biomarkers, but their regulatory mechanisms remain elusive.28637482
Hepatitis C Virus-Related Hepatocellular CarcinomaEpigenetic AlterationsValidation of a serum microRNA panel as biomarkers for early diagnosis of hepatocellular carcinoma post-hepatitis C infection in Egyptian patients.28638226
Hollings Cancer CenterEpigenetic AlterationsEach miRNA can show HCC progression.28638226
Hollings Cancer CenterEpigenetic AlterationsExpression of the selected miRNAs in serum was significantly lower in HCC patients than in the healthy controls, except for miR-1269 and miR-494.28638226
Carcinoma, Transitional Cell, NeoplasmsEpigenetic AlterationsHypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma.28638274
Carcinogenesis, NeoplasmsEpigenetic AlterationsHypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression.28638274
Liver carcinomaEpigenetic AlterationsmiRNA Signature of Hepatocellular Carcinoma Vascularization: How the Controls Can Influence the Signature.28639131
Hollings Cancer CenterEpigenetic AlterationsTo assess the differences existing in the quantitative miRNA gene expression in HCC on tissue according to two different liver controls.28639131
Hollings Cancer CenterEpigenetic AlterationsStill we observed the deregulation of some common miRNAs as promising in HCC cancerogenesis and progression.28639131
Kidney NeoplasmEpigenetic AlterationsWhile the miRNA profiles of renal tumors have been extensively explored, knowledge of their circulating counterparts is limited.28639257
NeoplasmsEpigenetic AlterationsAdvanced tumors, characterized as stage III and IV, were associated with specific miRNA signatures that significantly differ from both controls and earlier stage ccRCC cases.28639257
Conventional (Clear Cell) Renal Cell Carcinoma, Late stageEpigenetic AlterationsLarge-scale genome-wide screening of circulating microRNAs in clear cell renal cell carcinoma reveals specific signatures in late-stage disease.28639257
NeoplasmsEpigenetic AlterationsCirculating miRNAs have shown great promises as noninvasive diagnostic and predictive biomarkers in several solid tumors.28639257
Renal Cell Carcinoma PathwayEpigenetic AlterationsIn summary, our results suggest that circulating miRNAs may provide insights into renal cell carcinoma progression.28639257
Sample Size CalculationEpigenetic AlterationsExpression of circulating microRNA-5196 was correlated with SSc parameters.28639412
fibrogenesis, Sample Size CalculationEpigenetic AlterationsExogenous delivery of microRNA-5196 reduced Fra2 and TIMP-1 expression suggesting that it may be used as a potential modulator of fibrogenesis in SSc.28639412
Sample Size CalculationEpigenetic AlterationsThese results suggest that microRNA-5196 can be used as a potential biomarker characterising SSc.28639412
Stomach CarcinomaEpigenetic AlterationsEvaluation of serum microRNA biomarkers for gastric cancer based on blood and tissue pools profiling: the importance of miR-21 and miR-331.28641313
Stomach CarcinomaEpigenetic AlterationsHigh stability and disease-specific disarrangements suggest that microRNA molecules (miRNAs) present in body fluids are ideally suited for diagnostic applications, including gastric cancer (GC).28641313
Primary NeoplasmEpigenetic AlterationsThe results indicate that the majority of potential serum miRNA biomarkers may originate from tissues other than the primary tumour.28641313
cervical cancerEpigenetic AlterationsMicroRNA-337 inhibits cell proliferation and invasion of cervical cancer through directly targeting specificity protein 1.28641487
cervical cancerEpigenetic AlterationsWe found that microRNA-337 expression was significantly downregulated in cervical cancer tissues and cell lines.28641487
cervical cancerEpigenetic AlterationsThe ectopic expression of microRNA-337 suppressed cell proliferation and invasion of cervical cancer in vitro.28641487
cervical cancerEpigenetic AlterationsFurthermore, specificity protein 1 was identified as a direct target of microRNA-337 in cervical cancer.28641487
cervical cancerEpigenetic AlterationsThe expression of specificity protein 1 increased in cervical cancer tissues and negatively correlated with microRNA-337 expression level.28641487
cervical cancerEpigenetic AlterationsMoreover, rescue experiments revealed that upregulation of specificity protein 1 could rescue the effects of microRNA-337 on cervical cancer cells.28641487
cervical cancerEpigenetic AlterationsTaken together, these findings collectively demonstrate that microRNA-337 exerts its tumor-suppressing roles in cervical cancer by directly targeting specificity protein 1, thereby indicating a potential novel potential therapeutic target for patients with cervical cancer.28641487
Malignant Neoplasms, cervical cancer, NeoplasmsEpigenetic AlterationsAccumulated studies have demonstrated that the aberrant expression of microRNAs plays important roles in tumorigenesis and tumor development and potentially serves as therapeutic targets in various cancers including cervical cancer.28641487
cervical cancerEpigenetic AlterationsTherefore, the identification of specific microRNAs contributed to cervical cancer formation and progression would provide critical clues for the treatments for patients with this disease.28641487
Degenerative polyarthritisEpigenetic AlterationsIntra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats.28647469
Degenerative polyarthritisEpigenetic AlterationsAn OA model was induced surgically in rats, and subsequently treated with one single intra-articular injection of miRNA-140 agomir.28647469
Degenerative polyarthritisEpigenetic AlterationsIntra-articular injection of miRNA-140 can alleviate OA progression by modulating ECM homeostasis in rats, and may have potential as a new therapy for OA.28647469
Degenerative polyarthritisEpigenetic AlterationsmiRNA-146a, miRNA-155 and JNK expression levels in peripheral blood mononuclear cells according to grade of knee osteoarthritis.28647559
Degenerative polyarthritisEpigenetic AlterationsHowever, miRNA-146a and miRNA-155 expressions increased in the progressive stages (grade 3 and grade 4) in OA patients.28647559
Degenerative polyarthritisEpigenetic AlterationsOur data suggests that correlation of miRNAs regulating and signal pathways can play an important role in OA pathogenesis and disease progression.28647559
Osteoporotic FracturesEpigenetic AlterationsDistinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women.28650214
OsteoporosisEpigenetic AlterationsDNA methylation affects expression of associated genes and may contribute to the missing genetic effects from genome-wide association studies of osteoporosis.28650214
Osteoporosis, PostmenopausalEpigenetic AlterationsTo improve insight into the mechanisms of postmenopausal osteoporosis, we combined transcript profiling with DNA methylation analyses in bone.28650214
Adenocarcinoma of lung (disorder)Epigenetic AlterationsMicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma.28653805
Multiple Chronic Conditions, Malignant Neoplasms, MetastasisEpigenetic AlterationsAberrant microRNA expression is involved in the regulation of various cellular processes, such as proliferation and metastasis in multiple diseases including cancers.28653805
Malignant Neoplasms, Adenocarcinoma of lung (disorder), NeoplasmsEpigenetic AlterationsMicroRNA-30e-5p (miR-30e) was previously reported as an oncogenic or tumour suppressing miRNA in some malignancies, but its function in lung adenocarcinoma (LAC) remains largely undefined.28653805
Endometrial Carcinoma, NeoplasmsEpigenetic AlterationsLong non-coding RNA tumor suppressor candidate 7 advances chemotherapy sensitivity of endometrial carcinoma through targeted silencing of miR-23b.28653877
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsTUSC7 (tumor suppressor candidate 7) is an antisense long non-coding RNA and is downregulated and acts as a potential tumor suppressor in several malignant tumors.28653877
Endometrial Carcinoma, NeoplasmsEpigenetic AlterationsIn summary, long non-coding RNA TUSC7 was underexpressed in endometrial carcinoma, especially in endometrial carcinoma chemotherapy-resistant tissues and cell lines and acted as a potential tumor suppressor gene to inhibit cell growth as well as advance the chemotherapy sensitivity through targeted silencing of miR-23b, which might provide a new therapeutic target to endometrial carcinoma.28653877
Mitochondria, Nerve Degeneration, "Alzheimers Disease", Loading TechniqueEpigenetic AlterationsMitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might be involved in late-onset Alzheimers disease (LOAD), but evidence in humans is limited.28655136
Malignant neoplasm of thyroidEpigenetic AlterationsEffects of long non-coding RNA H19 and microRNA let7a expression on thyroid cancer prognosis.28655518
GDC Tumor Code Terminology, NeoplasmsEpigenetic AlterationsIn TC patients with tumor diameters>=1.0cm, lncRNA H19 mRNA expression was elevated, but miRNA let7a mRNA expression was reduced.28655518
GDC Tumor Code TerminologyEpigenetic AlterationsTC patients with a lower 5-year survival rate showed upregulated levels of lncRNA H19 expression and, downregulated levels of miRNA let7a expression.28655518
Tetranitromethane, Metastasis, NeoplasmsEpigenetic AlterationsLncRNA H19 and miRNA let7a expression, tumor diameter, TNM stage and lymph node metastasis were independent prognostic factors of TC.28655518
DiscordanceEpigenetic AlterationsThe discordance between the high prevalence of mutations in these 2 genes and their limited biological impact raise the question of the potential role of dysregulated epigenetic modifiers in normal aging hematopoiesis, which may include support to failing hematopoiesis.28655780
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are a group of non-protein-coding, short single-stranded RNAs, which are considered as promising molecular markers and therapeutic targets in several cancers.28656198
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-661 promotes non-small cell lung cancer progression by directly targeting RUNX3.28656235
Malignant Neoplasms, Carcinogenesis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsIncreasing evidence indicates that abnormal microRNA (miRNA) expression contributes to the carcinogenesis and progression of multiple human cancers, including non-small cell lung cancer (NSCLC).28656235
Breast Cancer CellEpigenetic AlterationsmiRNA-661 (miR-661) has previously been demonstrated to be important in the development of various human cancer types.28656235
Malignant NeoplasmsEpigenetic AlterationsTherefore, miRNAs exhibit the potential to act as biomarkers for the diagnosis, treatment and prognosis of human malignancies.28656235
Papillary thyroid carcinomaEpigenetic AlterationsMicroRNA-150 targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in papillary thyroid carcinoma.28656254
Malignant Neoplasms, Papillary thyroid carcinoma, Malignant neoplasm of thyroid, F9 geneEpigenetic AlterationsDysregulation of microRNAs is well-known to contribute to the development of various cancers, including papillary thyroid carcinoma (PTC), which accounts for 80-90% of all thyroid cancer cases.28656254
Glioblastoma Multiforme PathwayEpigenetic AlterationsLow expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma.28656255
Malignant NeoplasmsEpigenetic AlterationsAccumulating evidence demonstrates that dysregulated microRNAs (miRNAs) play a critical role in tumorigenesis and progression of various cancers.28656255
NeoplasmsEpigenetic AlterationsIn recent years, accumulating evidence has demonstrated that microRNAs (miRs, miRNAs) may serve an important role in the occurrence and development of tumors.28656260
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs play roles in almost all aspects of cancer biology, and can be secreted into the circulation and serve as molecular biomarkers for the early diagnosis of cancer.28656287
Metastasis, Liver carcinomaEpigenetic AlterationsLong non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186-5p to promote the tumorigenesis and metastasis of hepatocellular carcinoma.28656879
Malignant NeoplasmsEpigenetic AlterationsLong non-coding RNA plasmacytoma variant translocation 1 has been reported to be dysregulated and plays a crucial role in various cancers.28656879
Ulcerative Colitis, Crohn DiseaseEpigenetic AlterationsThese 45 variants are significantly enriched for protein-coding changes (n = 13), direct disruption of transcription-factor binding sites (n = 3), and tissue-specific epigenetic marks (n = 10), with the last category showing enrichment in specific immune cells among associations stronger in Crohns disease and in gut mucosa among associations stronger in ulcerative colitis.28658209
Conventional (Clear Cell) Renal Cell Carcinoma, MetastasisEpigenetic AlterationsLong noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling.28659173
Malignant NeoplasmsEpigenetic AlterationsRecent evidences showed that long noncoding RNAs (lncRNAs) are frequently dysregulated and play important roles in various cancers.28659173
Hurthle Cell TumorEpigenetic AlterationsThese results indicate that the noncoding RNAs MALAT1 and miR-885 show increased expression in neoplastic follicular and Hurthle cell thyroid neoplasms compared to normal thyroid tissues.28660408
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmicroRNA-145-3p inhibits non-small cell lung cancer cell migration and invasion by targeting PDK1 via the mTOR signaling pathway.28661070
Neoplasm MetastasisEpigenetic AlterationsWe found that miR-29a overexpression increased DNA methylation of suppressor of cytokine signaling 1 (SOCS1) promoter was associated with HCC metastasis in vitro and in vivo.28661477
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsTen eleven translocation (TET) enzymes convert 5-methylcytosine (5-mC) to 5-hydroxy-methylcytosine (5-hmC) and have crucial roles in biological and pathological processes by mediating DNA demethylation, however, the functional role of this epigenetic mark and the related enzymes in hepatocellular carcinoma (HCC) progression remains unknown.28661477
Hollings Cancer Center, Neoplasm MetastasisEpigenetic AlterationsIn conclusion, our findings demonstrate that 5-hmC loss is an epigenetic hallmark of HCC, and miR-29a is an important epigenetic modifier, promoting HCC metastasis through TET-SOCS1-MMP9 axis silencing.28661477
Primary malignant neoplasmEpigenetic AlterationsThe results offer a new strategy for epigenetic cancer therapy.28661477
Metastasis, Liver carcinomaEpigenetic AlterationsMicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TET-SOCS1-MMP9 signaling axis.28661477
Kidney NeoplasmEpigenetic AlterationsPromoter methylation has emerged as a promising class of epigenetic biomarkers for diagnosis and prognosis of renal cell tumors (RCTs).28662726
Acute myocardial infarctionEpigenetic AlterationsMicroRNAs (miRs) have shown to exert fibrotic and anti-fibrotic effects in preclinical models of acute myocardial infarction (AMI).28663047
NeoplasmsEpigenetic AlterationsTumors with loss of MLH1/PMS2 were subsequently tested for BRAF mutation or MLH1 promoter methylation to identify tumors with likely epigenetic inactivation of MLH1.28664346
Lupus Erythematosus, Systemic, Lupus ErythematosusEpigenetic AlterationsFinally, miRNA expression in T lymphocytes and MVs of healthy individuals was compared with those of systemic lupus erythematosus (SLE) patients.28665018
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsAccumulating evidence demonstrates that aberrant miRNAs contribute to hepatocellular carcinoma (HCC) development and progression.28666208
Hollings Cancer CenterEpigenetic AlterationsHowever, the roles of various miRNAs in HCC remain to be determined.28666208
Carcinoma of lung, MetastasisEpigenetic AlterationsFurthermore, SATB2 suppressed lung cancer cell invasion and metastasis and regulated the expression of EMT-related proteins and histone methylation by G9a.28667416
Colorectal Cancer PathwayEpigenetic AlterationsTranscription factor-microRNA associations and their impact on colorectal cancer survival.28667784
CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) and Transcription Factors (TFs) both influence messenger RNA (mRNA) expression, disrupting biological pathways involved in carcinogenesis and prognosis.28667784
Primary malignant neoplasmEpigenetic AlterationsAs many miRNAs target multiple mRNAs, thus influencing a multitude of biological pathways, deciphering which miRNAs are important for cancer development and survival is difficult.28667784
Primary malignant neoplasmEpigenetic AlterationsFive factors, comprising 21 miRNAs, altered survival in rectal cancer subjects; four of these five factors improved survival and one factor reduced survival.28667784
Malignant tumor of colonEpigenetic AlterationsOne factor comprising four miRNAs reduced survival in colon cancer subjects.28667784
Colorectal Cancer PathwayEpigenetic AlterationsIn summary, our data suggest that expression of TFs and their related miRNAs influence survival after diagnosis with colorectal cancer.28667784
Myeloid Leukemia, ChronicEpigenetic AlterationsMutations in genes associated with epigenetic regulations such as DNMT3A and ASXL1 seem to play an important role in the pathogenesis of CML progression and TKI-resistance independent of ABL1 KD mutations.28667884
Intervertebral disc disorderEpigenetic AlterationsDysregulation of microRNAs (miRNAs) is involved in the development of IDD.28667916
Fibrosis AssessmentEpigenetic AlterationsMicroRNAs are reported to play important roles in regulating fibrosis in different organs.28669725
Malignant tumor of colonEpigenetic AlterationsMicroRNA 375 regulates proliferation and migration of colon cancer cells by suppressing the CTGF-EGFR signaling pathway.28670764
Clinical Coordinator, Colorectal Cancer Pathway, Malignant tumor of colonEpigenetic AlterationsMicroRNA 375 (MIR375) is significantly down regulated in human colorectal cancer (CRC) tissues; we have previously identified MIR375 as a colon cancer associated microRNA (miRNA).28670764
Malignant NeoplasmsEpigenetic AlterationsCCAT2 (colon cancer-associated transcript 2) gene is affiliated with long non-coding RNAs, which are often found to have important regulatory roles in cancers.28671055
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-133b expression associates with clinicopathological features and prognosis in glioma.28675056
Malignant Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsRecently, microRNA-133b (miR-133b) dysregulation has been shown to play a key role in several human cancers, as well as glioma.28675056
Breast CarcinomaEpigenetic AlterationsThis study provided evidence that long non-coding RNA MALAT1 was up-regulated in breast cancer tissues and cell lines.28675122
Neoplasm MetastasisEpigenetic AlterationsLong non-coding RNAs recently were identified as key mediators of cancer metastasis.28675122
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsThe co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer.28675510
Primary malignant neoplasmEpigenetic AlterationsMiRNAs also contribute to cellular pathways leading to cancer.28675510
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsWe use data from 217 colorectal cancer (CRC) cases to evaluate differences in TSGs and OGs expression between paired CRC and normal mucosa and evaluate how TSGs and OGs are associated with miRNAs.28675510
Decreased platelet countEpigenetic AlterationsMicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction.28677771
Decreased platelet countEpigenetic AlterationsHowever, the regulatory role of miRNAs in the pathogenesis of thrombocytopenia in ITP remains unclear.28677771
Metastatic hepatocellular carcinomaEpigenetic AlterationsMicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1.28677785
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsMicroRNAs (miRNAs) play critical roles in hepatocellular carcinoma (HCC).28677785
Primary malignant neoplasmEpigenetic AlterationsSingle nucleotide polymorphisms (SNPs) in microRNA-binding sites located in the 3-untranslated region (UTR) of target genes can have an effect on the interaction of microRNA-mediated regulation, which results in changes in the expression levels of target genes ultimately associated with cancer risk and patient prognosis.28677815
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe expression of PDE3A in patients with NSCLC and its DNA methylation status were analyzed in NSCLC cohort in TCGA database.28678321
Adenocarcinoma of lung (disorder), Non-Small Cell Lung CarcinomaEpigenetic AlterationsHeat map of PDE3A expression and methylation in NSCLC patient cohort in TCGA database indicated a negative association between PDE3A expression and DNA methylation in lung adenocarcinoma.28678321
Mammary NeoplasmsEpigenetic AlterationsDNA methylation analysis for the ALKBH3 promoter region was carried out by pyrosequencing (PyroMark Q24) in 265 primary breast tumours and 30 proximal normal breast tissue samples along with 8 breast-derived cell lines.28679371
Stomach CarcinomaEpigenetic AlterationsBRD4 promotes gastric cancer progression through the transcriptional and epigenetic regulation of c-MYC.28681984
Stomach CarcinomaEpigenetic AlterationsWe report here that BRD4 increases the proliferation and represses the apoptosis of gastric cancer cells through activating c-MYC via transcriptional and epigenetic regulation mechanisms.28681984
Pulmonary HypertensionEpigenetic AlterationsDysregulation of microRNA-214 and PTEN contributes to the pathogenesis of hypoxic pulmonary hypertension.28684904
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-300 promotes apoptosis and inhibits proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/b-catenin signaling pathway by targeting CUL4B in pancreatic cancer cells.28685847
Hypertensive diseaseEpigenetic Alterationsa-Adducin gene promoter DNA methylation and the risk of essential hypertension.28686109
Metastasis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsDown-regulated microRNA-375 expression as a predictive biomarker in non-small cell lung cancer brain metastasis and its prognostic significance.28688608
CarcinogenesisEpigenetic AlterationsmicroRNAs (miRNAs) play critical roles in carcinogenesis.28689850
ovarian neoplasm, NeoplasmsEpigenetic AlterationsGenetic Versus Epigenetic BRCA1 Silencing Pathways: Clinical Effects in Primary Ovarian Cancer Patients: A Study of the Tumor Bank Ovarian Cancer Consortium.28691938
InflammationEpigenetic AlterationsMicroRNAs (miRs) are small noncoding RNAs that regulate gene expression, including immune activation and inflammation.28692540
HIV-1 Infection PathwayEpigenetic AlterationsUnique microRNA expression in the colonic mucosa during chronic HIV-1 infection.28692540
Primary malignant neoplasmEpigenetic AlterationsNormal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age.28693600
Breast CarcinomaEpigenetic AlterationsWe tested the relation of established breast cancer risk factors, age, body mass index, parity, and family history of disease, with DNA methylation adjusting for potential variation in cell-type proportions.28693600
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsDNA methylation changes with age occur at regulatory regions, and are further exacerbated in cancer, suggesting that age influences breast cancer risk in part through its contribution to epigenetic dysregulation in normal breast tissue.28693600
Asthma Pathway, Chronic Obstructive Airway Disease, Asthma-Chronic Obstructive Pulmonary Disease Overlap SyndromeEpigenetic AlterationsExpression profiling of miRNA-145 and miRNA-338 in serum and sputum of patients with COPD, asthma, and asthma-COPD overlap syndrome phenotype.28694694
Asthma Pathway, obstructive diseaseEpigenetic AlterationsThe main finding of this work is that the expression of miRNA-338 is higher in the supernatant of different obstructive diseases than in peripheral blood, while miRNA-145 is higher only in the supernatant of asthma patients.28694694
Asthma Pathway, Chronic Obstructive Airway DiseaseEpigenetic AlterationsDifferences in sputum miRNA expression profile were observed between patients with ACOS and asthma or COPD, which underline the potential role of miRNA as a biomarker that is able to discriminate patients with ACOS, asthma, and COPD.28694694
Asthma Pathway, Chronic Obstructive Airway DiseaseEpigenetic AlterationsThe expression of both selected miRNAs is higher in the supernatant of asthma and COPD patients than in controls.28694694
Primary malignant neoplasmEpigenetic AlterationsUrinary microRNAs (miRNAs) are emerging as a clinically useful tool for early and non-invasive detection of various types of cancer.28694731
Refractory Cytopenia of ChildhoodEpigenetic AlterationsConcentrations of all let-7 miRNAs (let-7a, let-7b, let-7c, let-7d, let-7e and let-7g) were significantly higher in urine samples obtained from RCC patients compared to healthy controls (P < 0.001; P < 0.001; P = 0.005; P = 0.006; P = 0.015 and P = 0.002, respectively).28694731
Primary malignant neoplasm, Liver carcinomaEpigenetic AlterationsMicroRNAs could mediate the targeted coding gene and the targeted non-coding RNA to form endogenous competition, which have an important regulatory role in tumorigenesis of many types of cancer, including hepatocellular carcinoma.28695771
Liver carcinomaEpigenetic AlterationsMicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839.28695771
Breast Carcinoma, MetastasisEpigenetic AlterationsCollagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer.28697793
Chronic arthritisEpigenetic AlterationsOur data suggest that the epigenetic configuration at gene promoters regulates cell-specific LPS-induced responses and primes SF to sustain their inflammatory response in chronic arthritis.28701277
Squamous cell carcinoma of esophagusEpigenetic AlterationsEpigenetic silencing of miR-203 in Kazakh patients with esophageal squamous cell carcinoma by MassARRAY spectrometry.28703658
Sex CharacteristicsEpigenetic AlterationsSexual dimorphisms of mRNA and miRNA in human/murine heart disease.28704447
NeoplasmsEpigenetic AlterationsmiR-451 is a tumor suppressive microRNA with several target genes, including Macrophage migration inhibitory factor (MIF).28704499
Colorectal Cancer PathwayEpigenetic AlterationsE2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer.28704519
NeoplasmsEpigenetic AlterationsHowever, 3 untranslated regions (3 UTR) mutations can also disrupt or create miRNA target sites, and trigger oncogene activation or tumor suppressor inactivation.28704519
Malignant neoplasm of urinary bladderEpigenetic AlterationsLong noncoding RNA linc00346 promotes the malignant phenotypes of bladder cancer.28705739
Carcinoma, Malignant neoplasm of urinary bladderEpigenetic AlterationsMore and more reports have demonstrated that long noncoding RNAs (lncRNAs) play an important role in the development of a variety of carcinomas, including bladder cancer.28705739
Esophageal carcinomaEpigenetic AlterationsTherefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer.28707457
Esophageal carcinomaEpigenetic AlterationsClinical value of integrated-signature miRNAs in esophageal cancer.28707457
Esophageal carcinomaEpigenetic AlterationsAnalysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer.28707457
NeoplasmsEpigenetic AlterationsRecent studies have revealed that microRNAs (miRNAs) play important roles as oncogenes or tumor suppressors in tumorigenesis and tumor development, by negatively regulating protein expression.28708205
Breast CarcinomaEpigenetic AlterationsEpigenetic Changes of the ESR1 Gene in Breast Tissue of Healthy Women: A Missing Link with Breast Cancer Risk Factors?28708432
Obesity, CarcinogenesisEpigenetic AlterationsThus, it is speculated that such ESR1 epigenetic changes may be influenced or shaped by obesity and reproductive history-related factors before and during breast carcinogenesis.28708432
Postmenopausal stateEpigenetic AlterationsThese findings provide new hints about the relationship between epigenetic changes within the ESR1 gene CpG island and postmenopausal obesity and aging in cancer-free women.28708432
Endometrial Carcinoma, NeoplasmsEpigenetic AlterationsEpigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity and reduced recurrence-free survival.28709704
NeoplasmsEpigenetic AlterationsTumors with MMR abnormalities by IHC or MSI and MLH1 methylation were classified as epigenetic MMR deficiency while those without MLH1 methylation were classified as probable MMR mutations.28709704
Endometrial CarcinomaEpigenetic Alterations466 endometrial cancers were classified; 75% as MMR proficient, 20% epigenetic MMR defects, and 5% as probable MMR mutations.28709704
NeoplasmsEpigenetic AlterationsThe epigenetic MMR defect tumors median volume was 10,220mm3 compared to 3321mm3 and 2,846mm3, for MMR proficient and probable MMR mutations respectively (P<0.0001).28709704
Endometrioid tumorEpigenetic AlterationsEndometrioid EC cases with epigenetic MMR defects had significantly reduced recurrence-free survival (RFS).28709704
Ductal Carcinoma, Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsConcordance of DNA methylation profiles between breast core biopsy and surgical excision specimens containing ductal carcinoma in situ (DCIS).28711544
Noninfiltrating Intraductal Carcinoma, Primary malignant neoplasmEpigenetic AlterationsHere, we compared genome-scale DNA methylation measured in matched core biopsy and surgical specimens from DCIS, including specific DNA methylation biomarkers of subsequent invasive cancer.28711544
Noninfiltrating Intraductal CarcinomaEpigenetic AlterationsOur results indicate that DNA methylation measured in core biopsies are representative of the matched surgical specimens and suggest that DCIS biomarkers measured in core biopsies can inform clinical decision-making.28711544
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsThe miRNAs function either as tumor suppressors or as oncogenes in tumorigenesis, and little is known about the clinical significance of miRNA expression profiles in oral cancers.28713923
Malignant neoplasm of mouthEpigenetic AlterationsThe differential regulation of microRNAs is associated with oral cancer.28713923
Stomach Carcinoma, MetastasisEpigenetic AlterationsMicroRNA-379 inhibits metastasis and epithelial-mesenchymal transition via targeting FAK/AKT signaling in gastric cancer.28713929
Stomach CarcinomaEpigenetic AlterationsAccumulating evidence demonstrates that aberrant miRNAs contribute to gastric cancer (GC) development and progression.28713929
Clinical Coordinator, Admitting diagnosisEpigenetic AlterationsDNA methylation of two PTPRH promoter fragments was analyzed by pyrosequencing in a group of CRC, and AD patients as well as NM samples and CRC cell lines.28713969
Clinical CoordinatorEpigenetic AlterationsThe mean DNA methylation levels of these two regions were significantly higher in CRC than in NM.28713969
Colorectal NeoplasmsEpigenetic AlterationsThe results indicate that PTPRH is downregulated in colorectal tumors and its expression is epigenetically regulated via DNA methylation and chromatin modifications.28713969
Primary malignant neoplasmEpigenetic AlterationsGenes encoding different RPTPs are affected by aberrant epigenetic regulation in cancer.28713969
NeoplasmsEpigenetic AlterationsMicroRNAs regulate the expression of genes involved in several important cancer-related processes including cell adhesion, proliferation, and tumour angiogenesis.28714375
Malignant NeoplasmsEpigenetic AlterationsDNA methylation-based immune response signature improves patient diagnosis in multiple cancers.28714863
Breast CarcinomaEpigenetic AlterationsHere, we profiled DNA methylation markers to identify a methylation of TIL (MeTIL) signature that recapitulates TIL evaluations and their prognostic value for long-term outcomes in breast cancer (BC).28714863
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsEffect of microRNA-135a on Cell Proliferation, Migration, Invasion, Apoptosis and Tumor Angiogenesis Through the IGF-1/PI3K/Akt Signaling Pathway in Non-Small Cell Lung Cancer.28715819
Malignant Neoplasms, MetastasisEpigenetic AlterationsAberrant microRNA expression has been implicated in metastasis of cancers.28716024
CarcinogenesisEpigenetic AlterationsEpigenetic changes, including DNA methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis.28716111
Malignant Neoplasms, ovarian neoplasmEpigenetic AlterationsTwo microRNA signatures for malignancy and immune infiltration predict overall survival in advanced epithelial ovarian cancer.28716985
ovarian neoplasm, NeoplasmsEpigenetic AlterationsMicroRNAs have been established as key regulators of tumor gene expression and as prime biomarker candidates for clinical phenotypes in epithelial ovarian cancer (EOC).28716985
NeoplasmsEpigenetic AlterationsWe analyzed the coexpression and regulatory structure of microRNAs and their co-localized gene targets in primary tumor tissue of 20 patients with advanced EOC in order to construct a regulatory signature for clinical prognosis.28716985
Primary malignant neoplasmEpigenetic AlterationsWe validated the prognostic relevance of the immunological module microRNAs in the publicly available The Cancer Genome Atlas data set.28716985
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsEvaluation of epigenetic inactivation of vascular endothelial growth factor receptors in head and neck squamous cell carcinoma.28718364
Pituitary AdenomaEpigenetic AlterationsRIZ1 and histone methylation status in pituitary adenomas.28718376
Pituitary AdenomaEpigenetic AlterationsPromoter region methylation of RIZ1 may play an important role in the epigenetic silencing of RIZ1 expression in pituitary adenomas, which may translate into important diagnostic and therapeutic applications.28718376
Neoplasms, Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2.28718378
Glioblastoma MultiformeEpigenetic AlterationsOverexpression of microRNA-613 in the glioblastoma cell lines U87 and U251 retarded cell growth and induced cell apoptosis.28718378
Glioblastoma MultiformeEpigenetic AlterationsUpregulation of microRNA-613 inhibited glioblastoma cell clone formation, invasion and migration.28718378
Glioblastoma MultiformeEpigenetic AlterationsFurthermore, we demonstrated that arginase-2 was directly regulated by microRNA-613 and played an essential role in mediating the biological effects of microRNA-613 in glioblastoma.28718378
Glioblastoma MultiformeEpigenetic AlterationsRe-expression of arginase-2 markedly reversed the inhibitory properties of microRNA-613 in glioblastoma cells.28718378
Glioblastoma MultiformeEpigenetic AlterationsTaken together, our data provide compelling evidence that human cytomegalovirus reduced the level of microRNA-613 which functions as an anti-onco-miRNA in glioblastoma, primarily by downregulating the expression of arginase-2.28718378
Inflammation Mediators, Admitting diagnosis, "Alzheimers Disease", Down SyndromeEpigenetic AlterationsWe hypothesized that an inflammation-mediated dysregulation of these miRNAs may occur in patients with Down syndrome (DS) and Alzheimers disease (AD).28720071
Admitting diagnosisEpigenetic AlterationsIn particular, we provide evidence of a dysregulation of these two immunomodulatory miRNAs in AD with a potential therapeutical implication, deserving further investigation.28720071
Stomach CarcinomaEpigenetic AlterationsPlasma microRNA-based signatures to predict 3-year postoperative recurrence risk for stage II and III gastric cancer.28722210
Stomach CarcinomaEpigenetic AlterationsOur aim was to identify plasma microRNA (miRNA)-based signatures to predict 3-year postoperative recurrence risk for patients with stage II and III gastric cancer (GC), so as to provide insights for individualized adjuvant therapy.28722210
Hypoxia, Cerebrovascular accidentEpigenetic AlterationsLevels of all 3 microRNAs depended on platelet numbers in a platelet spike-in experiment but were unaffected by chemical hypoxia in Neuro2a cells and in experimental stroke models.28724745
Graves DiseaseEpigenetic AlterationsIn the Graves disease patients, altered DNA methylation profile and modified age prediction accuracy were noted for TRIM59 and FHL2 with aberrant hypermethylation observed for the former and aberrant hypomethylation for the latter.28725932
Tetranitromethane, Non-Small Cell Lung CarcinomaEpigenetic AlterationsAge at surgery (hazard ratio [HR] 1.021, 95% confidence interval [CI] 1.003-1.040), TNM stages II (HR 3.858, 95% CI 2.449-6.078) and III (HR 3.099, 95% CI 1.911-5.023), and miRNA-21 (HR 1.002, 95% CI 1.001-1.003) and miRNA-155 expression (HR 1.131, 95% CI 1.064-1.202) were independent prognostic factors in NSCLC patients.28727276
Tetranitromethane, Non-Small Cell Lung CarcinomaEpigenetic AlterationsMiRNA-21 expression with TNM stages II (HR 1.282, 95% CI 1.197-1.372) and III (HR 1.247, 95% CI 1.149-1.354) interacted to affect prognosis in NSCLC patients.28727276
Tetranitromethane, Non-Small Cell Lung CarcinomaEpigenetic AlterationsOlder age, higher clinical TNM stage, and increased miRNA-21 and miRNA-155 expression in NSCLC tissue were independently associated with poor survival in NSCLC patients.28727276
TetranitromethaneEpigenetic AlterationsMiRNA-21 expression and clinical TNM stage interacted to affect prognosis.28727276
Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XEpigenetic AlterationsDNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome.28727822
Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent, ETV3 wt Allele, Metabolic Syndrome XEpigenetic AlterationsThe prevalence of type 2 diabetes (T2D) and the metabolic syndrome (MetS) is increasing and several studies suggested an involvement of DNA methylation in the development of these metabolic diseases.28727822
Diabetes Mellitus, Non-Insulin-Dependent, ETV3 wt AlleleEpigenetic AlterationsAltered levels of DNA methylation in PBLs of specific loci might serve as a biomarker for T2D or MetS, although further investigation is required.28727822
Clinical CoordinatorEpigenetic AlterationsAberrant DNA methylation of CpG islands occurred frequently in CRC and associated with transcriptional silencing of key genes.28730335
Breast CarcinomaEpigenetic AlterationsThe regulatory role of RSK4 in breast cancer development was mediated by AKT and extracellular signal-regulated kinase (ERK) signaling pathways and the expression of RSK4 was altered by DNA methylation in promoter regions.28731146
Periodontal DiseasesEpigenetic AlterationsPeriodontal therapy resets the DNA methylation status of inflammatory gene for COX-2 in patients with periodontal disease.28736819
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have been consistently demonstrated to be involved in colorectal cancer as either tumour oncogenes or tumour suppressors.28738328
Rheumatoid Arthritis, Right armEpigenetic AlterationsmicroRNA-125b (miR-125b) has been reported to be increased in rheumatoid arthritis (RA).28738524
Metastatic melanoma, melanomaEpigenetic AlterationsHere, we reported miR-23a as a novel metastasis-associated miRNA that played a remarkable role in modulating melanoma invasive and metastatic capacity and was of great value in predicting melanoma metastasis and prognosis.28740547
Metastasis, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsRecently, microRNAs (miRNAs) have been implicated in modulating cancer invasion and metastasis, and are proved as potential non-invasive biomarkers in sera for various tumors.28740547
Malignant NeoplasmsEpigenetic AlterationsOne of these miRNAs, miR-144 has been found aberrantly expressed in a variety of human malignancies.28742204
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsUp-regulation of long non-coding RNA PCAT-1 correlates with tumor progression and poor prognosis in gastric cancer.28742205
Non-Small Cell Lung CarcinomaEpigenetic AlterationsWhole blood microRNA expression may not be useful for screening non-small cell lung cancer.28742859
Carcinoma of lungEpigenetic AlterationsAt least seven studies have suggested that microRNA levels in whole blood can be diagnostic for lung cancer.28742859
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsAdditionally, no difference for microRNA expression was noticed in microarray-based microRNA profiles of whole blood of 12 stage IA-IIIB NSCLC cases before and three-four weeks after tumor resection.28742859
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThese findings show that whole blood microRNA expression profiles lack diagnostic value for high-risk screening of NSCLC, though such value may exist for selective sub-groups of NSCLC and control populations.28742859
Carcinoma of lung, Lung mass, Non-Small Cell Lung CarcinomaEpigenetic AlterationsQiagen(r) PAXgene(tm) Blood miRNA System was used to collect blood and extract RNA from it for 85 pathologic stage I-IV non-small cell lung cancer (NSCLC) cases and 76 clinically-relevant controls who had a benign pulmonary mass, or a high risk of developing lung cancer because of a history of cigarette smoking or age >60 years.28742859
ovarian neoplasm, NeoplasmsEpigenetic AlterationsIn this work, a negative correlation between DDR1 and a tumor suppressor miRNA, miR-199a-3p, was observed in ovarian cancer tissues.28743276
Glioblastoma Multiforme PathwayEpigenetic AlterationsSomatic mutation, DNA copy number, DNA methylation, gene expression, and protein array data from the TCGA lower-grade glioma database were analyzed for molecular-radiographic associations.28751449
Coronary Artery DiseaseEpigenetic AlterationsCirculating microRNAs (miRNAs/miRs) are regulated in patients with coronary artery disease.28751542
NSD1 protein, humanEpigenetic AlterationsThrough an integrative analysis, we discovered frequent silencing of the histone H3 K36 methyltransferase NSD1 as the sole chromatin-modifying gene silenced by DNA methylation in ccRCC.28754676
NSD1 protein, human, "Sotos syndromeEpigenetic AlterationsccRCC harboring epigenetic silencing of NSD1 displayed a specific genome-wide methylome signature consistent with the NSD1 mutation methylome signature observed in Sotos syndrome.28754676
IL13 geneEpigenetic AlterationsIn PBMCs of allergic rhinitis participants, 42 sites showed significant DNA methylation changes of 2% or greater.28755526
IL13 geneEpigenetic AlterationsBlood and nasal epigenetics correlate with allergic rhinitis symptom development in the environmental exposure unit.28755526
IL13 geneEpigenetic AlterationsEpigenetic alterations may represent new therapeutic targets and/or biomarkers of allergic rhinitis (AR).28755526
Chronic Kidney DiseasesEpigenetic AlterationsCholesterol lowering treatment restores blood global DNA methylation in chronic kidney disease (CKD) patients.28755807
Chronic Kidney DiseasesEpigenetic AlterationsDNA methylation was significantly lower in CKD patients vs. controls (4.06 +- 0.20% vs. 4.27 +- 0.17% mCyt, p = 0.0001).28755807
Chronic Kidney DiseasesEpigenetic AlterationsOur results demonstrate that CKD patients have a lower degree of DNA methylation and that cholesterol lowering treatment restores mCyt DNA concentrations to levels similar to healthy controls.28755807
1-methyl-1-piperidinomethane sulfonateEpigenetic AlterationsmiRNA-16, miRNA-17, and miRNA-486 in plasma and tissue of MPM patients were significantly correlated.28757678
DiseaseEpigenetic AlterationsAll the miRNA levels were decreased in patients with MPM or ASB, supporting the role of circulating miRNAs as a potential tool for diseases associated with exposure to asbestos fibers.28757678
1-methyl-1-piperidinomethane sulfonate, Malignant Pleural Mesothelioma, AsbestosisEpigenetic AlterationsTo identify a pattern of miRNAs as possible diagnostic biomarkers for patients with malignant pleural mesothelioma (MPM) and asbestosis (ASB) and as prognostic biomarkers for MPM patients.28757678
Pancreatic carcinoma, NeoplasmsEpigenetic AlterationsOur findings showed that miR-377 through targeting DNMT1 could reduce DNA methylation of some tumor suppressor genes and restore their expression in pancreatic cancer cells.28758420
NeoplasmsEpigenetic AlterationsThe frequency and timing of chemo brain and tumor brain occurrence and persistence strongly suggest they may be epigenetic in nature and associated with altered gene expression.28758896
Colorectal Carcinoma, NeoplasmsEpigenetic AlterationsDown-regulated long non-coding RNA SNHG1 inhibits tumor genesis of colorectal carcinoma.28759957
Clinical Coordinator, Colorectal Carcinoma, Primary malignant neoplasmEpigenetic AlterationsColorectal carcinoma (CRC) is the vital cancer mortality worldwide and the long noncoding RNAs (lncRNAs) is considered as an important biomarker.28759957
Pancreatic carcinoma, Primary malignant neoplasmEpigenetic AlterationsCirculating microRNAs (miRNAs) are emerging as novel biomarkers for various types of cancer including pancreatic cancer (PC).28759959
Dilated Cardiomyopathy PathwayEpigenetic AlterationsHistone Modification Is Correlated With Reverse Left Ventricular Remodeling in Nonischemic Dilated Cardiomyopathy.28760462
Heart failureEpigenetic AlterationsIt has been shown that epigenetic modification, such as methylation or acetylation of the histone, is one of the most important upstream signals in cardiac failure.28760462
Primary malignant neoplasmEpigenetic AlterationsLong Noncoding RNA NEAT1 Promotes Proliferation and Invasion via Targeting miR-181a-5p in Non-Small Cell Lung Cancer.28762332
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe relationship between DNA-methylation and high-grade PCa was examined in a cohort of 102 prospectively enrolled men who received standard 12-core prostate biopsies.28762545
Primary malignant neoplasmEpigenetic AlterationsDNA-methylation intensities of GSTP1, RASSF1, and APC were higher in biopsy cores from men diagnosed with GS >= 7 cancer compared to men with diagnosed GS 6 disease.28762545
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsIn men diagnosed with PCa, DNA-methylation profiling can detect under-sampled high-risk PCa in prostate biopsy specimens through a field effect.28762545
Prostate Cancer PathwayEpigenetic AlterationsEpigenetic risk score improves prostate cancer risk assessment.28762545
melanomaEpigenetic AlterationsMT1A is aberrantly silenced by DNA methylation of 5 MT1A CGI in melanoma.28764861
Degenerative polyarthritisEpigenetic AlterationsIdentification of differentially expressed microRNAs in knee anterior cruciate ligament tissues surgically removed from patients with osteoarthritis.28765881
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDown-regulation of long noncoding RNA RP11-713B9.1 contributes to the cell viability in non-small cell lung cancer (NSCLC).28765887
Primary malignant neoplasmEpigenetic AlterationsRecent studies have demonstrated that long noncoding RNAs (lncRNAs) serve important roles in cancer occurrence and progression.28765887
Primary malignant neoplasmEpigenetic AlterationsNon-coding RNA 886 (nc886) has been suggested to serve tumor-suppressing roles in several cancer cells.28765891
Breast Cancer Cell, Nasopharyngeal carcinomaEpigenetic AlterationsMicroRNAs (miRs) act as important regulators during the development and progression of human cancer; however, the regulatory mechanism of miR-663 in nasopharyngeal carcinoma (NPC) remains unclear.28765905
Malignant Neoplasms, OsteosarcomaEpigenetic AlterationsMicroRNA-635 inhibits the malignancy of osteosarcoma by inducing apoptosis.28765920
Clinical CoordinatorEpigenetic AlterationsIn addition, bioinformatics methods demonstrated that PHF8 was a putative target of microRNA (miR)-488, and miR-488 was able to inhibit the expression of PHF8 in CRC cells.28765946
Breast Carcinoma, Primary malignant neoplasmEpigenetic AlterationsClinical Relevance of microRNA Expressions in Breast Cancer Validated Using the Cancer Genome Atlas (TCGA).28766230
NeoplasmsEpigenetic AlterationsMiRNA-205 has tumor suppressive properties, whereas miRNA-18a has both oncogenic and tumor suppressive roles.28766230
Breast CarcinomaEpigenetic AlterationsMiRNA-744s role in breast cancer is unknown but is tumor-suppressive in vitro.28766230
Breast Carcinoma, Mammary Neoplasms, NeoplasmsEpigenetic AlterationsBy utilizing a big dataset (TCGA) with sufficient statistical power, we found that high expression of miRNA-18a, miRNA-205, and miRNA-744 in the breast tumor samples were all associated with better overall survival in ER/PR-positive, lymph node-negative disease supporting their role as a tumor suppressor in breast cancer.28766230
Breast Carcinoma, CarcinogenesisEpigenetic AlterationsMicroRNAs (miRNAs) play a critical role in the carcinogenesis and progression of breast cancer.28766230
Breast CarcinomaEpigenetic AlterationsWe hypothesize that high expression of all three miRNAs is associated with a better survival based on their known functions in breast cancer.28766230
Subarachnoid HemorrhageEpigenetic AlterationsMicroRNA Changes in Cerebrospinal Fluid After Subarachnoid Hemorrhage.28768799
S-AdenosylhomocysteineEpigenetic AlterationsMiRNA profiles from 27 SAH patients and 10 neurologically healthy patients passed quality control.28768799
S-AdenosylhomocysteineEpigenetic AlterationsSAH is associated with marked changes in the cerebrospinal fluid miRNA profile.28768799
Cerebral IschemiaEpigenetic AlterationsMicroRNAs (miRNAs) are pathophysiologically involved in acute cerebral ischemia.28768799
Noninfiltrating Intraductal Carcinoma, S-AdenosylhomocysteineEpigenetic AlterationsIn the validation, 66 miRNAs showed a relative increase in cerebrospinal fluid from SAH patients compared with neurologically healthy patients (P<0.001); 2 (miR-21 and miR-221) showed a relative increase in SAH patients with DCI compared with those without (P<0.05) in both the screening and validation.28768799
Papillary thyroid carcinomaEpigenetic AlterationsThe expression and function of long noncoding RNA lncRNA-ATB in papillary thyroid cancer.28770959
Malignant neoplasm of urinary bladderEpigenetic AlterationsSOCS3 was found significantly declined, while microRNA-221 (miR-221) obviously up-regulated in bladder cancer tissue.28770966
Primary malignant neoplasmEpigenetic AlterationsmiR-125a-3p is a non-coding RNA that can reduce cell proliferation and migration in cancer.28771224
Malignant neoplasm of liverEpigenetic AlterationsOn the basis of our previous research, FUT can be regulated by miRNA, which influences the proliferation and invasion of breast and hepatocellular cancer cells.28771224
Malignant tumor of colonEpigenetic AlterationsMicroRNA-27a Promotes the Proliferation and Invasiveness of Colon Cancer Cells by Targeting SFRP1 through the Wnt/b-Catenin Signaling Pathway.28772260
Imprinting (Psychology), AlloisoleucineEpigenetic AlterationsLoss of imprinting (LOI) is an epigenetic event that relaxes an allele-specific restriction on gene expression.28775169
Multiple Myeloma, LipomaEpigenetic AlterationsAs a CpG island is absent in miR-28-5- but present in its host gene, LPP (LIM domain containing preferred translocation partner in lipoma), we hypothesized that miR-28-5p is epigenetically silenced by promoter DNA methylation of its host gene in multiple myeloma.28775176
Malignant NeoplasmsEpigenetic AlterationsThis is the first report of epigenetic regulation of the intronic miR-28-5p expression by promoter DNA methylation of its host gene, hence warrants further study in different cancers.28775176
Multiple MyelomaEpigenetic AlterationsEpigenetic silencing of LPP/miR-28 in multiple myeloma.28775176
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsmiR-28-5- is a tumour suppressor microRNA implicated in cancers.28775176
Plaque, AtheroscleroticEpigenetic AlterationsAtherosclerotic plaque rupture is accompanied by an acute decrease in the carotid plaque expression of micro-RNAs (miRs)-221 and miR-222.28779016
Squamous cell carcinomaEpigenetic AlterationsFour PTEN-targeting co-expressed miRNAs and ACTN4- targeting miR-548b are independent prognostic biomarkers in human squamous cell carcinoma of the oral tongue.28779483
Primary malignant neoplasmEpigenetic AlterationsThese findings were validated in The Cancer Genome Atlas (TCGA) cohort (n = 131) for both miRNAs (miR-548b: p = 0.027; miR-18a: p = 0.001).28779483
Malignant neoplasm of urinary bladderEpigenetic AlterationsDown-regulation of microRNA-224 -inhibites growth and epithelial-to-mesenchymal transition phenotype -via modulating SUFU expression in bladder cancer cells.28780419
Secondary malignant neoplasm of pancreasEpigenetic AlterationsYB-1 expression promotes pancreatic cancer metastasis that is inhibited by microRNA-216a.28782557
Non-Small Cell Lung CarcinomaEpigenetic AlterationsDown-regulation of long non-coding RNA MEG3 indicates an unfavorable prognosis in non-small cell lung cancer: Evidence from the GEO database.28782577
Breast Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-1297 contributes to tumor growth of human breast cancer by targeting PTEN/PI3K/AKT signaling.28791363
Breast CarcinomaEpigenetic AlterationsIncreasing evidence confirms that aberrant miRNA expression contributes to breast cancer (BC) development and progression.28791363
Adenocarcinoma of lung (disorder)Epigenetic AlterationsComprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression.28791371
Tetranitromethane, MetastasisEpigenetic AlterationsWe used an integrative computational method to identify LUAD-specific key miRNAs related to TNM stage and lymphatic metastasis from the TCGA database.28791371
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-212 functions as a tumor-suppressor in human non-small cell lung cancer by targeting SOX4.28791372
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIncreasing evidence has revealed that aberrant expression of miRNAs contributes to non-small cell lung cancer (NSCLC) development and progression.28791372
Non-Small Cell Lung CarcinomaEpigenetic AlterationsHowever, the roles and mechanisms of various miRNAs in NSCLC remain to be determined.28791372
Breast Cancer Cell, HOXA11-AS gene, MetastasisEpigenetic AlterationsLong non-coding RNA HOXA11-AS promotes cell proliferation and metastasis in human breast cancer.28791375
Malignant Neoplasms, Breast CarcinomaEpigenetic AlterationsLong non-coding RNAs (LncRNAs) have previously been demonstrated to be important in multiple cancers, including breast cancer.28791375
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer.28791380
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain-derived neurotrophic factor.28791400
Stomach CarcinomaEpigenetic AlterationsIt has previously been demonstrated that microRNAs (miRNAs) are actively involved in the pathogenesis of gastric cancer.28791400
Stomach CarcinomaEpigenetic AlterationsTherefore, miRNAs have been proposed as promising therapeutic targets in gastric cancer patients.28791400
Carcinoma of larynxEpigenetic AlterationsMicroRNA-195 inhibits growth and invasion of laryngeal carcinoma cells by directly targeting DCUN1D1.28791411
Lung Neoplasms, Colorectal Cancer PathwayEpigenetic AlterationsSmoking has been reported to be associated with changes in DNA methylation in blood and in lung tumour tissues, although there has been scant investigation of how epigenetic factors may be implicated in the increased risk of developing colorectal cancer.28791728
Smoking Behaviors, Colorectal NeoplasmsEpigenetic AlterationsTo identify epigenetic changes associated with smoking behaviours, we performed epigenome-wide analysis of DNA methylation in colorectal tumours from 36 never-smokers, 47 former smokers, and 13 active smokers, and in adjacent mucosa from 49 never-smokers, 64 former smokers, and 18 active smokers.28791728
Intervertebral Disc DegenerationEpigenetic AlterationsMicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration.28793234
Intervertebral disc disorder, Intervertebral Disc DegenerationEpigenetic AlterationsMicroRNAs (miRNAs) have been shown to be involved in the pathogenesis of intervertebral disc degeneration (IDD).28793234
Primary malignant neoplasmEpigenetic AlterationsThe microRNA (miR)-302 family consisting four members, miR-302a, miR-302b, miR-302c and miR-302d, plays an important role in diverse biological processes, and regulates many pathological changes, including cancer.28795345
Clinical Coordinator, Colorectal Cancer Pathway, Malignant Neoplasms, InflammationEpigenetic AlterationsColorectal cancer (CRC) is one of the most common malignant tumors worldwide, which is a heterogeneous disease and main risk factors are associated with inflammation, family history, genetic mutations, epigenetics, and so on.28796265
Adenocarcinoma of lung (disorder)Epigenetic AlterationsEffects of long noncoding RNA SPRY4-IT1-mediated EZH2 on the invasion and migration of lung adenocarcinoma.28796375
Antilymphocyte Serum, Amyotrophic Lateral SclerosisEpigenetic AlterationsEpigenetic differences between monozygotic twins discordant for amyotrophic lateral sclerosis (ALS) provide clues to disease pathogenesis.28797086
Muscular Atrophy, Antilymphocyte SerumEpigenetic AlterationsHere we report the epigenetic profiling of five monozygotic twin pairs discordant for ALS, four with classic ALS and one with the progressive muscular atrophy ALS variant, in whom previous whole genome sequencing failed to uncover a genetic basis for their disease discordance.28797086
Liver carcinomaEpigenetic AlterationsLong noncoding RNA PVT1 promotes hepatocellular carcinoma progression through regulating miR-214.28800314
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsLong noncoding RNAs (lncRNA) have been verified to be involved in hepatocellular carcinoma (HCC) progression.28800314
Malignant Neoplasms, Carcinoma of lungEpigenetic AlterationsStudies suggest an important role of microRNAs (miRNAs) in a variety of cancers, including lung cancer.28800790
NeoplasmsEpigenetic AlterationsThe detection of recurrent KMT2D/MLL2 alterations implicates epigenetic regulation in the pathogenesis of HS and supports the notion of transdifferentiation from a genetically similar but phenotypically distinct tumor of a different lineage.28805986
CataractEpigenetic AlterationsThis miRNA-TATA-box/3 UTR-gene-regulation network may contribute to cataract pathogenesis.28806956
CataractEpigenetic AlterationsRNAhybrid online tool was applied to predict the binding between significantly regulated miRNAs in cataract lenses and target mRNAs.28806956
Lung Diseases, ObstructiveEpigenetic AlterationsMicroRNA-181c inhibits cigarette smoke-induced chronic obstructive pulmonary disease by regulating CCN1 expression.28806967
Chronic Obstructive Airway DiseaseEpigenetic AlterationsAccumulating evidence has shown that the dysregulation of miRNAs is crucially involved in the pathogenesis and development of COPD.28806967
Injury woundsEpigenetic AlterationsMicroRNA-132 with Therapeutic Potential in Chronic Wounds.28807666
diabetic, diabetic ulcerEpigenetic AlterationsWe found significantly reduced microRNA-132 (miR-132) expression in human diabetic ulcers compared with normal skin wounds and also in skin wounds of leptin receptor-deficient (db/db) diabetic mice compared with wild-type mice.28807666
Primary malignant neoplasmEpigenetic AlterationsThe data of miRNA expression, mRNA expression and DNA methylation were downloaded from The Cancer Genome Atlas.28809126
Adenocarcinoma of lung (disorder)Epigenetic AlterationsComprehensive epigenetic analysis of the signature genes in lung adenocarcinoma.28809126
Adenocarcinoma of lung (disorder)Epigenetic AlterationsTaken together, the epigenetic alterations of signature genes may hold promise for becoming biomarkers for the early detection of lung adenocarcinoma.28809126
Malignant NeoplasmsEpigenetic AlterationsAberrant DNA methylation is a hallmark of many cancers.28809778
NeoplasmsEpigenetic AlterationsThis approach suggests that DNA methylation status in CGIs of some tumor suppressor genes could be driven by E2 availability, subsequently inducing the activation of the ERa pathway.28809778
Colorectal Cancer PathwayEpigenetic AlterationsDynamic plasma microRNAs are biomarkers for prognosis and early detection of recurrence in colorectal cancer.28809863
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsPlasma microRNAs (miRNAs) are promising non-invasive biomarkers for colorectal cancer (CRC) prognosis.28809863
OtotoxicityEpigenetic AlterationsThis study demonstrates that CpG-specific DNA methylation in the ERCC3 promoter region may be involved in benzene-induced epigenetic modification and it may contribute to benzene-induced hematotoxicity.28813025
OtotoxicityEpigenetic AlterationsIn order to test whether specific CpG sites of ERCC3 play an important role in benzene-induced epigenetic changes and whether the specific methylation patterns are associated with benzene hematotoxicity, we analyzed the promoter methylation levels of individual CpG sites, transcription factor binding motif and the correlation between aberrant CpG methylation and hematotoxicity in 76 benzene-exposed workers and 24 unexposed controls in China.28813025
NeoplasmsEpigenetic AlterationsCollectively, these findings revealed that TUG1 functions as an oncogenic lncRNA that promotes tumor progression, at least partially, by functioning as an endogenous sponge and competing for miR-382 binding to the miRNA target EZH2.28813705
SERPINB3 wt AlleleEpigenetic AlterationsOur data highlight the importance of CpG location and correct estimation of DNA methylation level for highly accurate early diagnosis of OSCC.28814981
Liver carcinoma, Hollings Cancer Center, Metastasis, Primary malignant neoplasmEpigenetic AlterationsMetastasis is the major cause of the poor prognosis of hepatocellular carcinoma (HCC), and increasing evidence supports the contribution of miRNAs to cancer progression.28817119
Carcinoma of lung, MetastasisEpigenetic AlterationsDownregulation of MicroRNA-330 Correlates with the Radiation Sensitivity and Prognosis of Patients with Brain Metastasis from Lung Cancer.28817811
Chronic Obstructive Airway DiseaseEpigenetic AlterationsBlood global DNA methylation is decreased in non-severe chronic obstructive pulmonary disease (COPD) patients.28818709
Chronic Obstructive Airway DiseaseEpigenetic AlterationsDNA methylation was significantly lower in COPD patients vs. controls (4.20 +- 0.18% mCyt vs. 4.29 +- 0.18% mCyt, p = 0.02).28818709
Chronic Obstructive Airway DiseaseEpigenetic AlterationsFurthermore, DNA methylation in COPD patients with moderate disease was significantly lower than that in patients with mild disease (4.14 +- 0.15% mCyt vs. 4.23 +- 0.19% mCyt, p < 0.05).28818709
Chronic Obstructive Airway DiseaseEpigenetic AlterationsThe presence and severity of COPD is associated with progressively lower DNA methylation in blood.28818709
Cardiac ArrestEpigenetic AlterationsInitial studies suggested that miRNAs, such as the brain-enriched miR-124-3p, might improve outcome prediction after out-of-hospital cardiac arrest.28819446
Primary malignant neoplasmEpigenetic Alterations5-Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification that has been linked to gene regulation and cancer pathogenesis.28820176
Liver diseasesEpigenetic AlterationsActually, several miRNAs have been reported to be biomarker candidates of liver diseases.28823616
Liver diseasesEpigenetic AlterationsThe profiling of the selected miRNAs can be useful to distinguish different types of liver diseases.28823616
Idiopathic Pulmonary FibrosisEpigenetic AlterationsAltered epigenetic features in circulating nucleosomes in idiopathic pulmonary fibrosis.28824731
Fibrosis AssessmentEpigenetic AlterationsPolymorphisms and environmentally induced epigenetic variations seem to determine individual susceptibility to the development of lung fibrosis.28824731
Idiopathic Pulmonary FibrosisEpigenetic AlterationsMoreover, we found differences in epigenetic profiles between untreated IPF patients and those receiving anti-fibrotic therapy with mH2A1.1 and 5mC being significantly lower in untreated than in treated patients (p < 0.01 and p < 0.05, respectively).28824731
membrane attack complex location, Lung diseasesEpigenetic AlterationsMicroRNA (miRNA) has been recently recognized as a biomarker of various diseases; however, there are no known miRNAs associated with Mycobacterium avium complex (MAC) pulmonary disease.28827075
Breast Carcinoma, NeoplasmsEpigenetic AlterationsLong noncoding RNA linc-ITGB1 (linc-ITGB1) was reported to serve as a tumor promoter in breast cancer (BC).28829502
CO-methylating acetyl-CoA synthase activity, Nonstress test, Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsTo this end, we applied gene chip technology to analyze miRNA expression in patients with stable angina (SA), non-ST elevation ACS (NSTE-ACS), and ST-segment elevation myocardial infarction (STEMI).28830367
InflammationEpigenetic AlterationsCompared with those in patients with STEMI, differentially expressed microRNAs in controls and patients with SA or NSTE-ACS were involved in inflammation, protein phosphorylation, and cell adhesion.28830367
CO-methylating acetyl-CoA synthase activity, Acute Coronary SyndromeEpigenetic AlterationsHowever, it is unclear whether miRNAs can be used as biomarkers for acute coronary syndrome (ACS).28830367
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMalignant cells in AML often exhibit chromosomal and other genetic or epigenetic abnormalities that are useful in prognostic risk assessment.28834593
Primary malignant neoplasmEpigenetic AlterationsLong Noncoding RNA PlncRNA-1 Promotes Colorectal Cancer Cell Progression by Regulating the PI3K/Akt Signaling Pathway.28835319
Malignant NeoplasmsEpigenetic AlterationsAccumulating evidence has indicated that long noncoding RNA (lncRNA) PlncRNA-1 plays an important regulatory role in cancers.28835319
Colorectal Cancer PathwayEpigenetic AlterationsCCAT1 and CCAT2 long noncoding RNAs, located within the 8q.24.21 gene desert, serve as important prognostic biomarkers in colorectal cancer.28838211
Neuroendocrine TumorsEpigenetic AlterationsFrequent silencing of RASSF1A by DNA methylation in thymic neuroendocrine tumours.28838380
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsAberrant methylation of promoter CpG islands (CGIs) of tumour suppressor genes is a common epigenetic mechanism underlying cancer pathogenesis.28838380
Neuroendocrine TumorsEpigenetic AlterationsHerein, we sought to identify genes that could serve as epigenetic targets for thymic neuroendocrine tumour (NET) therapy.28838380
Metastasis, Liver carcinomaEpigenetic AlterationsEpigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma.28844099
Hollings Cancer CenterEpigenetic AlterationsThus, PRSS3 is a potential prognostic biomarker and an epigenetic target for intervention of human HCC.28844099
Hollings Cancer CenterEpigenetic Alterations* Epigenetic silencing of PRSS3 facilitates growth, migration, and invasion of HCC.28844099
Ulcerative Colitis-Associated Colorectal AdenocarcinomaEpigenetic AlterationsA Panel of Methylated MicroRNA Biomarkers for Identifying High-Risk Patients With Ulcerative Colitis-Associated Colorectal Cancer.28847750
Malignant neoplasm of urinary bladderEpigenetic AlterationsGene Expression, DNA Methylation and Prognostic Significance of DNA Repair Genes in Human Bladder Cancer.28848075
NeoplasmsEpigenetic AlterationsHigh grade tumors had significantly lower levels of global DNA methylation (P=0.04).28848075
diabeticEpigenetic AlterationsEffect of the Diabetic Environment On the Expression of MiRNAs in Endothelial Cells: Mir-149-5p Restoration Ameliorates the High Glucose-Induced Expression of TNF-a and ER Stress Markers.28848152
Metastasis, Renal Cell Carcinoma PathwayEpigenetic AlterationsLong non-coding RNA Z38 promotes cell proliferation and metastasis in human renal cell carcinoma.28849012
Malignant Neoplasms, Malignant neoplasm of kidney, Refractory Cytopenia of Childhood, Renal Cell Carcinoma PathwayEpigenetic AlterationsLong non-coding RNAs (LncRNAs) have been reported to serve roles in various types of malignancy, including human renal cell carcinoma (RCC), which is among the most common types of kidney cancer worldwide.28849012
Liver carcinomaEpigenetic AlterationsMicroRNA-302a inhibits cell proliferation and invasion, and induces cell apoptosis in hepatocellular carcinoma by directly targeting VEGFA.28849033
Malignant Neoplasms, Hollings Cancer CenterEpigenetic AlterationsAn increasing number of studies have demonstrated that microRNAs may be used as diagnostic, therapeutic and prognostic targets for human cancers, including HCC.28849033
Admitting diagnosisEpigenetic AlterationsThe results indicated that there were 35 strips of microRNA in the mild AD group, in which the difference of expression signal was >500 IU/ml.28849039
Admitting diagnosisEpigenetic AlterationsIt was concluded that microRNA-222 may affect the occurrence and development of AD through a variety of mechanisms, and may serve as a biomarker for the early diagnosis of AD.28849039
Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-543 inhibits proliferation, invasion and induces apoptosis of glioblastoma cells by directly targeting ADAM9.28849046
Primary malignant neoplasm, Glioblastoma MultiformeEpigenetic AlterationsThe abnormal expression of microRNAs (miRs) has been reported to be important in the formation and progression of various types of human cancer, including glioblastoma (GBM).28849046
Papillary thyroid carcinomaEpigenetic AlterationsMicroRNA-497 inhibits cellular proliferation, migration and invasion of papillary thyroid cancer by directly targeting AKT3.28849051
Papillary thyroid carcinoma, Neoplasms, F9 geneEpigenetic AlterationsEmerging studies have indicated the critical roles of microRNAs (miRs) in papillary thyroid cancer (PTC) formation and progression through function as tumor suppressors or oncogenes.28849051
OsteosarcomaEpigenetic AlterationsMicroRNA-643 regulates the expression of ZEB1 and inhibits tumorigenesis in osteosarcoma.28849077
Renal Cell Carcinoma PathwayEpigenetic AlterationsDownregulation of microRNA-15a suppresses the proliferation and invasion of renal cell carcinoma via direct targeting of eIF4E.28849086
NeoplasmsEpigenetic AlterationsThe downregulation of microRNA-15a has been reported in several human tumors.28849086
Non-Small Cell Lung CarcinomaEpigenetic AlterationsIdentification of long non-coding RNA 00312 and 00673 in human NSCLC tissues.28849087
Malignant NeoplasmsEpigenetic AlterationsThe long non-coding RNAs (lncRNAs) recently have been considered as key regulators of tumor malignant.28849087
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsThe clinical significance of microRNA (miR)-136-5p in hepatocellular carcinoma (HCC) has not been verified.28849100
Hollings Cancer CenterEpigenetic AlterationsmiR-136-5p may act as an anti-carcinoma miRNA, which is essential for HCC progression through the regulation of various signaling pathways.28849100
Neoplasms, Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB.28849154
Hypertensive diseaseEpigenetic AlterationsTherefore, other modified factors, including environmental factors, and nuclear gene and epigenetic modifications, may be involved in the pathogenesis of hypertension.28849157
PancreatitisEpigenetic AlterationsScreening and validation of differentially expressed extracellular miRNAs in acute pancreatitis.28849189
Barrett EsophagusEpigenetic AlterationsMicroRNA profile in neosquamous esophageal mucosa following ablation of Barretts esophagus.28852310
Barrett EsophagusEpigenetic AlterationsThese microRNAs were also more highly expressed in Barretts esophagus mucosa than matched proximal squamous and squamous mucosa from controls.28852310
Barrett EsophagusEpigenetic AlterationsNeosquamous mucosa arising after ablation of Barretts esophagus expresses microRNAs that may contribute to decreased barrier function and microRNAs that may be involved in the regulation of survival signaling pathways.28852310
Malignant Neoplasms, Squamous cell carcinoma, SERPINB3 wt Allele, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category TerminologyEpigenetic AlterationsDNA methylation has started a recent revolution in genomics biology by identifying key biomarkers for multiple cancers, including oral squamous cell carcinoma (OSCC), the most common head and neck squamous cell carcinoma.28852427
SERPINB3 wt AlleleEpigenetic AlterationsA multi-stage screening strategy was used to identify DNA-methylation-based signatures for OSCC prognosis.28852427
SERPINB3 wt AlleleEpigenetic AlterationsThe seven DNA methylation CpG sites were identified which were significantly associated with OSCC overall survival.28852427
SERPINB3 wt AlleleEpigenetic AlterationsPrognostic signature integrated of DNA methylation, gene expression, and clinical information provides a better prognostic prediction value for OSCC patients than that with clinical information only.28852427
Axis, Primary malignant neoplasmEpigenetic AlterationsLong Noncoding RNA FAL1 Promotes Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through the PTEN/AKT Signaling Axis in Non-Small Cell Lung Cancer.28854421
Primary malignant neoplasmEpigenetic AlterationsRecently, long non-coding RNAs (lncRNAs) have been found to have many biological effects in different cancer stages.28854421
CarcinogenesisEpigenetic AlterationsGlobal DNA methylation may affect chromosome structure and genomic stability and is involved in carcinogenesis.28854562
ArteriosclerosisEpigenetic AlterationsLittle is known regarding the epigenetic basis of atherosclerosis.28855511
Liver carcinomaEpigenetic AlterationsSerum long noncoding RNA urothelial carcinoma-associated 1: A novel biomarker for diagnosis and prognosis of hepatocellular carcinoma.28856933
Primary malignant neoplasmEpigenetic AlterationsObjective Long noncoding RNAs (lncRNAs) offer great potential as cancer biomarkers.28856933
Chronic Kidney DiseasesEpigenetic AlterationsIdentification of miR-16 as an endogenous reference gene for the normalization of urinary exosomal miRNA expression data from CKD patients.28859135
Amyotrophic Lateral SclerosisEpigenetic AlterationsIncrease in DNA methylation in patients with amyotrophic lateral sclerosis carriers of not fully penetrant SOD1 mutations.28859526
Antilymphocyte SerumEpigenetic AlterationsGlobal DNA methylation levels were significantly higher in blood DNA of ALS patients than in asymptomatic/paucisymptomatic carriers or family members non-carriers of SOD1 mutations, and a positive correlation between global DNA methylation levels and disease duration (months) was observed.28859526
Antilymphocyte SerumEpigenetic AlterationsThe present study suggests that global changes in DNA methylation might contribute to the ALS phenotype in carriers of not fully penetrant SOD1 mutations, thus reinforcing the role of epigenetic factors in modulating the phenotypic expression of the disease.28859526
Antilymphocyte SerumEpigenetic AlterationsWe collected DNA samples from five ALS families with not fully penetrant SOD1 mutations (p.Asn65Ser, p.Gly72Ser, p.Gly93Asp, and p.Gly130_Glu133del) searching for epigenetic differences among ALS patients, asymptomatic/paucisymptomatic carriers and non-carrier family members.28859526
Carcinoma of lungEpigenetic AlterationsmiR-493 is silenced in resistant lung cancer cell due to the aberrant DNA methylation.28859669
Carcinoma of lung, Primary malignant neoplasmEpigenetic AlterationsEpigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1).28859669
Primary malignant neoplasmEpigenetic AlterationsThe potential mechanisms regarding how methylation of microRNA(miRNA) CpG Island could regulate cancer cell chemo-resistance remains unclear.28859669
SF3B1 wt AlleleEpigenetic AlterationsTo date, most of the previous studies of miR-124 in MDS have focused on epigenetic changes and little is known about the underlying mechanism through which miR-124 regulates CDK6 expression.28861128
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsDown-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding.28863773
NeoplasmsEpigenetic AlterationsBoth miRNA-148a and miRNA-625-3p were down-regulated in the tumors compared to normal colonic mucosa.28863773
NeoplasmsEpigenetic AlterationsSignificantly lower expression of both miRNAs was noticed in tumors with budding phenomenon compared to tumors without it (median values of miRNA-148a were 0.314 and 0.753 respectively, p = 0.011, and 0.404 and 0.620 respectively for miRNA-625-3p, p = 0.036).28863773
NeoplasmsEpigenetic AlterationsSignificantly lower expression of miRNA-625-3p was detected in rectal tumors, compared to tumors in the colon (median 0.390 and 0.665 respectively, p = 0.037).28863773
NeoplasmsEpigenetic AlterationsThere was a significant relationship between low miRNA-148a and miRNA-625-3p expression and tumor budding, which is thought to represent epithelial-mesenchymal transition.28863773
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes.28863773
Clinical CoordinatorEpigenetic AlterationsBoth studied miRNAs may be associated with a more aggressive phenotype and could be the potential prognostic and predictive biomarkers in CRC.28863773
Hollings Cancer CenterEpigenetic AlterationsWe analyzed GPR155 expression, DNA methylation, and copy number in HCC cell lines.28863781
Hollings Cancer CenterEpigenetic AlterationsNo DNA methylation was detected, whereas copy number alterations were present in five (56%) HCC cell lines.28863781
Chronic Obstructive Airway DiseaseEpigenetic AlterationsDysregulation of microRNAs (miRNAs) has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), which is largely attributable to cigarette smoke (CS).28864214
Breast CarcinomaEpigenetic AlterationsHere we applied bisulfite sequencing to global mitochondrial DNA and whole genomic DNA methylation array from fifteen members of five three-female-generation families with one breast cancer patient in each family.28865962
Glioblastoma MultiformeEpigenetic AlterationsA 4-miRNAs signature predicts survival in glioblastoma multiforme patients.28869437
Lymphohistiocytosis, HemophagocyticEpigenetic AlterationsIn addition, we found out that the mean level of miR-133 (microRNA-133) was significant higher in LAHS than in benign disease associated HLH (18.83 +- 10.44 vs 5.82 +- 3.26, P 0.0001).28869447
Breast CarcinomaEpigenetic AlterationsLarge intergenic non-coding RNA-ROR as a potential biomarker for the diagnosis and dynamic monitoring of breast cancer.28869448
Peripheral Nervous System DiseasesEpigenetic AlterationsAberrant microRNA expression in patients with painful peripheral neuropathies.28870579
Peripheral Nervous System DiseasesEpigenetic AlterationsThus, peripheral neuropathies are associated with aberrant miRNA expression in white blood cells, sural nerve, and skin.28870579
Peripheral Nervous System DiseasesEpigenetic AlterationsThese miRNA patterns may help to identify factors that determine the painfulness of peripheral neuropathies and lead to druggable targets.28870579
Muscular AtrophyEpigenetic AlterationsThe course of the disease might reflect differential degree of muscle atrophy and signaling at miRNA levels.28870590
Antilymphocyte SerumEpigenetic AlterationsA significant over-expression of all miRNAs was observed in ALS patients versus controls, in male patients versus females, in patients with early onset versus patients with late onset, and in patients with long disease duration versus patients with short duration.28870590
Malignant Pleural Mesothelioma, NeoplasmsEpigenetic AlterationsTargomiRs are minicells (EnGeneIC Dream Vectors) loaded with miR-16-based mimic microRNA (miRNA) and targeted to EGFR that are designed to counteract the loss of the miR-15 and miR-16 family miRNAs, which is associated with unsuppressed tumour growth in preclinical models of malignant pleural mesothelioma.28870611
Primary malignant neoplasmEpigenetic AlterationsDNA methylation of leukocyte DNA has been proposed to be a biomarker for cancer that can be used to target patients for appropriate clinical implementation.28871451
Forecast of outcome, Adenocarcinoma of lung (disorder)Epigenetic AlterationsA Novel Long Non-Coding RNA, SOX21-AS1, Indicates a Poor Prognosis and Promotes Lung Adenocarcinoma Proliferation.28873379
Primary malignant neoplasmEpigenetic AlterationsIn recent years, long non-coding RNAs (lncRNAs) have been shown to be a novel class of regulators of cancer biological processes.28873379
melanomaEpigenetic AlterationsIRF6 is aberrantly silenced by DNA methylation of the 5 IRF6 CGI in melanoma.28877249
Primary malignant neoplasmEpigenetic AlterationsAlterations in Bronchial Airway miRNA Expression for Lung Cancer Detection.28877936
Carcinoma of lungEpigenetic AlterationsUsing epithelial brushings from the mainstem bronchus of patients undergoing bronchoscopy for suspected lung cancer (as part of the AEGIS-1/2 clinical trials), we profiled miRNA expression via small-RNA sequencing from 347 current and former smokers for which gene expression data were also available.28877936
Airway structureEpigenetic AlterationsFollowing removal of 6 low-quality samples, we used 138 patients (AEGIS-1) as a discovery set to identify four miRNAs (miR-146a-5p, miR-324-5p, miR-223-3p, and miR-223-5p) that were downregulated in the bronchial airway of lung cancer patients (ANOVA P < 0.002, FDR < 0.2).28877936
Carcinoma of lungEpigenetic AlterationsOur findings suggest that there are miRNAs whose expression is altered in the cytologically normal bronchial epithelium of smokers with lung cancer, and that they may regulate cancer-associated gene expression differences.28877936
Malignant tumor of colonEpigenetic AlterationsPrognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients.28878843
Stomach CarcinomaEpigenetic AlterationsmiRNA-4317 suppresses human gastric cancer cell proliferation by targeting ZNF322.28880489
Triple-Negative Breast Cancer FindingEpigenetic AlterationsPrognostic value of microRNA-9 and microRNA-155 expression in triple-negative breast cancer.28882698
Breast CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) are involved in regulation of epithelial-mesenchymal transition (EMT) during breast cancer progression.28882698
NeoplasmsEpigenetic AlterationsMicroRNA exerts a vital function in promoting or inhibiting tumor development.28884131
Hollings Cancer Center, Metastasis, Liver carcinoma, NeoplasmsEpigenetic AlterationsThe downregulation of microRNA-122 (miR-122) had been reported to be associated with tumor invasion and metastasis in hepatocellular carcinoma (HCC).28890291
Ischemic strokeEpigenetic AlterationsCirculating microRNAs (miRNAs) have been reported as diagnosis biomarkers and predictors in acute ischemic stroke (AIS).28892656
Subarachnoid Hemorrhage, AneurysmalEpigenetic AlterationsAltered Expression of MicroRNA-15a and Kruppel-Like Factor 4 in Cerebrospinal Fluid and Plasma After Aneurysmal Subarachnoid Hemorrhage.28893694
S-AdenosylhomocysteineEpigenetic AlterationsHowever, little is known about the role of microRNAs (miRNAs) in the phenotypic alteration after SAH.28893694
S-AdenosylhomocysteineEpigenetic AlterationsMicroarray analysis showed that 12 miRNAs including miR-15a were upregulated or downregulated both in the CSF and in plasma after SAH within 3 days.28893694
Squamous cell carcinoma of the head and neckEpigenetic AlterationsThere are important epigenetic differences between EBV-negative and EBV-positive NPCs, with EBV-negative NPC having a more similar hypermethylation profile to other head and neck squamous cell carcinomas than EBV-positive NPC.28893862
Communicable DiseasesEpigenetic AlterationsAfter adjusting for potential covariates in linear regression models, we found that HP infection, infection with virulent HP strains (CagA+) and severe CAG were significantly associated with an increase in DNA methylation age by ~0.4, 0.6 and 1 year (all P-values <0.05), respectively.28898235
Infection caused by Helicobacter pylori, Gastritis, AtrophicEpigenetic AlterationsAssociations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults.28898235
Carcinoma of lungEpigenetic AlterationsThus, epigenetic abnormalities may prime for changing oncogene senescence to addiction for a single key oncogene involved in lung cancer initiation.28898697
ovarian neoplasm, MetastasisEpigenetic AlterationsMicroRNA-30c inhibits metastasis of ovarian cancer by targeting metastasis-associated gene 1.28901313
Primary malignant neoplasmEpigenetic AlterationsThe involvement of passenger strands of miRNAs in cancer pathogenesis is a novel concept in miRNA research.28902136
Primary malignant neoplasmEpigenetic AlterationsThe ectopic expression of these miRNAs significantly inhibited cancer cell migration and invasion in ccRCC cells.28902136
Supraspinatus tearEpigenetic AlterationsDysregulated expression and DNA methylation of MMP and TIMP genes were found across the rotator cuff tendon samples of patients with supraspinatus tears.28902861
Tears body substanceEpigenetic AlterationsEpigenetic regulation of metalloproteinases and their inhibitors in rotator cuff tears.28902861
Tears body substanceEpigenetic AlterationsIn conclusion, MMPs and their inhibitors are regulated by epigenetic modifications and may play a role in rotator cuff tears.28902861
Primary malignant neoplasmEpigenetic AlterationsThe key mechanisms for this miRNA may be hsa-miR-3148-AR-pathways in cancer or hsa-miR-3148-PRKCA-pathways in cancer/glioma/ErbB signaling pathway.28904974
Primary malignant neoplasm, Glioblastoma Multiforme PathwayEpigenetic AlterationsAmong the downregulated miRNAs, MiR-3148 regulated the most target genes and was significantly enriched in pathways in cancer, glioma, and ErbB signaling pathway.28904974
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsFurthermore, our data revealed that SSTR1/sst1 expression might be regulated by specific miRNAs in PCa, including miR-24, which is downregulated in PCa samples and correlates inversely with SSTR1 expression.28905400
Division of Lung Diseases, Lung diseasesEpigenetic AlterationsThe significant Ago2-IP enrichment of targets of these miRNAs related to the TGF-b and/or Wnt pathways (NGF, DLD, HHEX) in TGF-b1-stimulated fibroblasts suggest a role for these miRNAs in lung diseases by affecting lung fibroblast function.28910321
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe prediction analyses of target genes and integrative analysis of mRNA and miRNA expression revealed eleven genes and eight miRNAs which were validated by RT-qPCR in plasma samples from 102 untreated PCa patients and 50 cancer-free individuals.28910345
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsThe combination of circulating mRNA and miRNA was useful for the diagnosis and prognosis of PCa.28910345
Prostate Cancer PathwayEpigenetic AlterationsCirculating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer.28910345
NeoplasmsEpigenetic AlterationsA total of 2,267 genes and 49 miRNAs were differentially expressed between normal and tumor samples.28910345
CHOANAL ATRESIA, POSTERIOREpigenetic AlterationsTwo genes, OR51E2 and SIM2, and two miRNAs, miR-200c and miR-200b, showed significant association with PCa.28910345
Hepatitis BEpigenetic AlterationsExpression Profiling of Cellular MicroRNA in Asymptomatic HBsAg Carriers and Chronic Hepatitis B Patients.28913356
Injury of liver, Hepatitis B, Complete atrioventricular blockEpigenetic AlterationsMicroRNAs (miRNAs) may serve as potential molecular markers to predict liver injury resulting from chronic hepatitis B (CHB).28913356
Complete atrioventricular blockEpigenetic AlterationsWe identified 79 and 203 differentially expressed miRNAs in the peripheral blood mononuclear cells of ASCs and CHB patients compared to HCs, respectively.28913356
Complete atrioventricular blockEpigenetic AlterationsSome of these miRNAs were common to ASCs and CHB patients, but another set of miRNAs that showed differential expression between ASCs and CHB patients was also identified.28913356
Arthritis, GoutyEpigenetic AlterationsMicroRNA-488 and -920 regulate the production of proinflammatory cytokines in acute gouty arthritis.28915828
Fibrosis AssessmentEpigenetic AlterationsBET-bromodomain inhibitors modulate epigenetic patterns at the diacylglycerol kinase alpha enhancer associated with radiation-induced fibrosis.28916223
Fibrosis AssessmentEpigenetic AlterationsWe have previously identified altered epigenetic patterns at a gene enhancer of the diacylglycerol kinase alpha (DGKA) locus in normal skin fibroblasts derived from fibrosis patients.28916223
Fibrosis AssessmentEpigenetic AlterationsInterference with epigenetic patterns of fibrosis predisposition may provide novel preventive therapies that improve radiotherapy.28916223
Cardiovascular DiseasesEpigenetic AlterationsWe found changes in miRNAs and other ex-RNAs with exercise (e.g., Y RNAs and tRNAs) implicated in cardiovascular disease.28916639
Perceived stress scaleEpigenetic AlterationsA major difference in miRNA expression patterns was observed between the lymphocyte populations from patients with pSS and controls.28916716
Sjogrens Syndrome", Autoimmune Diseases, Perceived stress scaleEpigenetic AlterationsMicroRNAs (miRNAs) play an important role in the pathogenesis of autoimmune diseases such as primary Sjogrens syndrome (pSS).28916716
Leukemia, Myelocytic, AcuteEpigenetic AlterationsMicro-RNA Profiling of Exosomes from Marrow-Derived Mesenchymal Stromal Cells in Patients with Acute Myeloid Leukemia: Implications in Leukemogenesis.28918518
Leukemia, Myelocytic, AcuteEpigenetic AlterationsGene regulatory networks in AML may be influenced by microRNAs (miRs) contained in exosomes derived from bone marrow mesenchymal stromal cells (MSCs).28918518
NeoplasmsEpigenetic AlterationsTumor and serum DNA methylation in women receiving preoperative chemotherapy with or without vorinostat in TBCRC008.28918548
Degenerative polyarthritisEpigenetic AlterationsMicroRNA-218-5p as a Potential Target for the Treatment of Human Osteoarthritis.28919376
Degenerative polyarthritisEpigenetic AlterationsEmerging evidence suggests that dysregulated microRNAs (miRNAs) play a pivotal role in osteoarthritis (OA), but the role of specific miRNAs remains unclear.28919376
AneurysmEpigenetic AlterationsAlginate oligosaccharide indirectly affects toll-like receptor signaling via the inhibition of microRNA-29b in aneurysm patients after endovascular aortic repair.28919708
Stomach CarcinomaEpigenetic AlterationsAssociation of microRNA Polymorphisms with the Risk of Gastric Cancer in a Romanian Population.28922434
Malignant Neoplasms, Stomach CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) play an important role in the occurrence and progression of human cancers, including gastric cancer.28922434
Primary malignant neoplasmEpigenetic AlterationsGiven their prevalence in the human genome, close correlation with gene expression and high chemical stability, these DNA epigenetic marks could serve as ideal biomarkers for cancer diagnosis.28925386
Squamous cell carcinomaEpigenetic AlterationsWe hypothesized that transformation of normal epidermis to cutaneous squamous cell carcinoma (cSCC) is causally linked to alterations in microRNAs (miRNA) expression.28925390
Squamous cell carcinomaEpigenetic AlterationsAlterations of microRNAs throughout the malignant evolution of cutaneous squamous cell carcinoma: the role of miR-497 in epithelial to mesenchymal transition of keratinocytes.28925390
Malignant Neoplasms, Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsDown-regulation of long non-coding RNA tumor suppressor candidate 7(TUSC7) contributes to tumorigenesis in several human cancers including glioma.28925483
Clinical Coordinator, NeoplasmsEpigenetic AlterationsWe have identified a DNA methylation profile regulating key cellular processes in CRC, resulting in a growth advantage to the tumor cells.28931069
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsGenetic and epigenetic alterations mark colorectal cancer (CRC).28931069
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsMicroRNAs (miRNAs) are short noncoding RNAs that play critical roles in human malignancies and can be used as biomarkers for cancer.28931080
Stomach CarcinomaEpigenetic AlterationsLong noncoding RNA (lncRNA) phosphatase and tensin homolog pseudogene 1 (PTENP1) is significantly downregulated in gastric cancer (GC), playing critical roles in GC progression.28931965
Secondary malignant neoplasm of rectumEpigenetic AlterationsMicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor.28932920
Clinical Coordinator, MetastasisEpigenetic AlterationsmiR-30a functions as a tumor-suppressive miRNA, which may provide a therapeutic strategy for metastasis of CRC.28932920
Neurodevelopmental Disorders, SyndromeEpigenetic AlterationsAn ever-increasing group of neurodevelopmental disorders due to derangements of epigenetic regulation involve both microdeletion and monogenic syndromes.28933030
Colorectal Cancer PathwayEpigenetic AlterationsLong non-coding RNA SNHG17 is an unfavourable prognostic factor and promotes cell proliferation by epigenetically silencing P57 in colorectal cancer.28933484
Malignant Neoplasms, Colorectal Cancer Pathway, Clinical CoordinatorEpigenetic AlterationsRecently, substantial evidence has demonstrated that long non-coding RNAs (lncRNAs) play critical roles in multiple cancers including colorectal cancer (CRC).28933484
InflammationEpigenetic AlterationsWe hypothesize that differential systemic levels of miRNA expression reflect miRNA dysregulation at sites of spinal inflammation or bone formation where these molecules contribute to the development of pathophysiological features typical of AxSpA.28938006
Axial spondyloarthritisEpigenetic AlterationsAssociation between circulating miRNAs and spinal involvement in patients with axial spondyloarthritis.28938006
Autoimmune DiseasesEpigenetic AlterationsDysregulation of miRNAs and their target genes contributes to the pathophysiology of autoimmune diseases.28938006
Malignant neoplasm of mouthEpigenetic AlterationsEpigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.28939082
SERPINB3 wt AlleleEpigenetic AlterationsMoreover, epigenetic therapy could be a promising strategy for the treatment of OSCC.28939082
Lichen PlanusEpigenetic AlterationsMicroRNAs in cutaneous lichen planus.28940245
Inflammatory dermatosisEpigenetic AlterationsMicroRNAs (miRNAs) are short RNAs encoded in both protein coding and noncoding areas of the genome, and have been found to be involved in the pathogenesis of some inflammatory skin diseases.28940245
Malignant NeoplasmsEpigenetic AlterationsDNA methylation in specific genomic regions, which had shown strongly association with disease genotypes, was an effective indicator to reveal the occurrence and development of cancers.28940471
Clinical CoordinatorEpigenetic AlterationsThese findings supported CNRIP1 and RUNX3 as potential DNA methylation biomarkers for CRC diagnosis and treatment, and our LC-MS/MS approach exhibited great advantages in the identification of regional DNA methylation biomarkers.28940471
Pancreatic carcinoma, MetastasisEpigenetic AlterationsLong non-coding RNA CRNDE sponges miR-384 to promote proliferation and metastasis of pancreatic cancer cells through upregulating IRS1.28940804
Malignant Neoplasms, Colorectal NeoplasmsEpigenetic AlterationsColorectal neoplasia differentially expressed (CRNDE), a vital cancer-related long non-coding RNA (lncRNA), has been brought to reports for playing quintessential functions in the growth and progression of several human malignancies.28940804
Primary malignant neoplasmEpigenetic AlterationsUltraconserved elements (UCEs) encoding noncoding RNAs serve as important regulators in cancer biology.28941722
Malignant tumor of colonEpigenetic AlterationsLong non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as a competing endogenous RNA.28943452
Multiple PregnancyEpigenetic AlterationsIn recent years, accumulating evidence indicates that long noncoding RNAs (lncRNAs) have emerged as powerful influence factors in the progression of multiple malignancies.28943452
Malignant tumor of colon, MetastasisEpigenetic AlterationsMoreover, HNF1A-AS1 functioned as an oncogene in metastasis of colon cancer in part through serving as a competing endogenous RNA to modulate miRNA-34a expression, subsequently with repression of miR-34a/SIRT1/p53 feedback loop and activation of canonical Wnt signaling pathway.28943452
NeoplasmsEpigenetic AlterationsThe data on positive correlation between the expression of microRNA-21 and microRNA-221 and negative receptor status of the tumor were confirmed.28944429
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThe expression of the tumor suppressing microRNA-125b decreased in samples of breast cancer expressing HER2 and ER and in triple negative breast cancer, which characterizes it as a universal marker of breast cancer.28944429
Breast CarcinomaEpigenetic AlterationsAn increase in the expression of microRNA-16 was shown in samples of breast cancer expressing HER2 and ER.28944429
Breast CarcinomaEpigenetic AlterationsThe expression of microRNA-17 decreased in triple negative breast cancer and increased in ER+, PR+, and HER+ types of breast cancer.28944429
Breast Carcinoma, NeoplasmsEpigenetic AlterationsSearch of MicroRNAs Regulating the Receptor Status of Breast Cancer In Silico and Experimental Confirmation of Their Expression in Tumors.28944429
Breast CarcinomaEpigenetic AlterationsThe expression of 9 microRNAs (16, 17, 21, 27, 125, 146, 155, 200a, and 221) was analyzed in 76 samples of breast cancer with various receptor phenotypes.28944429
Breast CarcinomaEpigenetic AlterationsThe expression of microRNAs 155, 27, and 200a did not differ in various types of breast cancer.28944429
Breast CarcinomaEpigenetic AlterationsMicroRNAs 16, 17, 21, 125b, 146b, and 221 can be promising markers for differential diagnostics of various phenotypes of breast cancer.28944429
Secondary malignant neoplasm of liver, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA (miR)-200 and miR-141 have been confirmed to be aberrantly expressed in colorectal cancer, however, whether miR-200 and miR-141 are involved in the progression of colorectal cancer, and their role in liver metastasis remain to be fully elucidated.28944840
Glioblastoma Multiforme PathwayEpigenetic AlterationsA total of 37 mRNAs and 10 miRNAs were identified, which were closely associated with the survival rates of patients with grade III glioma.28944855
Trauma Symptom Checklist for Children Questionnaire, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsPrevious studies have demonstrated that aberrantly expressed cancer-associated microRNAs (miRs) may be associated with tumorigenesis and tumor development in various types of cancer, including TSCC.28944863
Heart failure, Cardiac fibrosis, HypertrophyEpigenetic AlterationsmicroRNA 21 (miRNA-21) promotes the development of cardiac fibrosis, hypertrophy and heart failure.28944900
Heart failureEpigenetic AlterationsCirculating miRNA-21 is a promising biomarker for heart failure.28944900
Heart failureEpigenetic AlterationsFollow-up of the patients with heart failure indicated that miRNA-21-PV and miRNA-21-CS were correlated with prognosis, and miRNA-21-CS was efficient in predicting re-hospitalization for heart failure.28944900
Heart failureEpigenetic AlterationsCirculating miRNA-21 has potential to be a biomarker of heart failure.28944900
Liver carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-340 inhibits tumor cell proliferation, migration and invasion, and induces apoptosis in hepatocellular carcinoma.28944918
Liver carcinoma, Hollings Cancer CenterEpigenetic AlterationsMicroRNAs (miRs) are short RNAs that serve a role in the origination and progression of hepatocellular carcinoma (HCC).28944918
Malignant neoplasm of urinary bladderEpigenetic AlterationsLong non-coding RNA HULC promotes bladder cancer cells proliferation but inhibits apoptosis via regulation of ZIC2 and PI3K/AKT signaling pathway.28946549
Glioblastoma MultiformeEpigenetic AlterationsReduced circulating microRNA-203 predicts poor prognosis for glioblastoma.28946553
Primary malignant neoplasm, Glioblastoma MultiformeEpigenetic AlterationsMicroRNAs (miRNAs) have been demonstrated to play an important role in the development and progression of various types of cancer including glioblastoma (GBM).28946553
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) emerge as important regulators involved in malignant progression in some tumors.28946554
Malignant Neoplasms, Non-Small Cell Lung CarcinomaEpigenetic AlterationsBlood-circulating miRNAs have been reported to act as potential biomarkers in various cancers including non-small cell lung cancer (NSCLC).28946561
Metastasis, NeoplasmsEpigenetic AlterationsRecently, long noncoding RNAs (lncRNAs) have been served as key regulators implicated in tumor development and progression by promoting proliferation, invasion and metastasis.28946875
Acute heart failureEpigenetic AlterationsSerially measured circulating microRNAs and adverse clinical outcomes in patients with acute heart failure.28948688
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-21 (Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer.28957811
Clinical Coordinator, Carcinogenesis, Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-21 (miR-21) has been demonstrated to play an important role in carcinogenesis; however, its mechanism of action in colorectal cancer (CRC) has not been fully elucidated.28957811
Hollings Cancer Center, NeoplasmsEpigenetic AlterationsDown-regulation was observed for 11 miRNAs in HCC indicating their tumour suppression activity.28958640
Squamous cell carcinoma, Nasal Cavity and Paranasal Sinus CarcinomaEpigenetic AlterationsDeregulation of selected microRNAs in sinonasal carcinoma: Value of miR-21 as prognostic biomarker in sinonasal squamous cell carcinoma.28960576
Carcinogenesis, Triple-Negative Breast Cancer FindingEpigenetic AlterationsLong non-coding RNA ANRIL promotes carcinogenesis via sponging miR-199a in triple-negative breast cancer.28961506
Non-Small Cell Lung CarcinomaEpigenetic AlterationsThe diagnostic role of plasma circulating precursors of miRNA-944 and miRNA-3662 for non-small cell lung cancer detection.28964576
Carcinogenesis, NeoplasmsEpigenetic AlterationsTo date there is little known about role of miRNA precursors (pri-miRNA) in carcinogenesis and their utility as tumor markers.28964576
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmiRNA-944 and miRNA-3662 precursors as potential non-small cell lung cancer (NSCLC) markers were analyzed in plasma samples of 56 patients in an early stage of NSCLC and 100 healthy individuals.28964576
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCirculating pri-miRNA-944 and 3662 can improve non-invasive NSCLC detection of operable stages of SCC and AC.28964576
Carcinoma of lungEpigenetic AlterationsmiRNA precursors could be considered as novel potential lung cancer biomarkers.28964576
Colorectal Cancer PathwayEpigenetic AlterationsLong noncoding RNA ZEB1-AS1 expression predicts progression and poor prognosis of colorectal cancer.28967064
Breast Cancer Cell, Squamous cell carcinoma of esophagusEpigenetic AlterationsMicroRNAs (miRNAs) play important roles in the progression of human cancer including esophageal squamous cell carcinoma (ESCC).28968424
Malignant neoplasm of liverEpigenetic AlterationsOne-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.28968444
Primary malignant neoplasmEpigenetic AlterationsAn aberrant DNA methylation is a common feature in cancer but whether the link between one-carbon metabolism variants and cancer occurs through an altered DNA methylation is yet unclear.28968444
hearing impairmentEpigenetic AlterationsmiRNAs, which play important roles in inner ear development, were detected in all samples, i.e., in both young and old elderly subjects, whether with or without hearing loss.28968605
Retinoblastoma, Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-675 promotes glioma cell proliferation and motility by negatively regulating retinoblastoma 1.28970140
Glioblastoma Multiforme PathwayEpigenetic AlterationsPrevious studies indicated that microRNA (miR)-675 and its precursor lncRNA H19 were both overexpressed in glioma tissues, and H19 might play an oncogenic role.28970140
Glioblastoma Multiforme PathwayEpigenetic AlterationsIn addition, miR-675 may act as an oncogenic miRNA in glioma cells via regulating its target gene RB1.28970140
insulinomaEpigenetic AlterationsHere, we show at the pathway level that the majority of the insulinomas display mutations, copy number variants and/or dysregulation of epigenetic modifying genes, most prominently in the polycomb and trithorax families.28974674
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsLong non-coding RNA SBDSP1 (SBDSP1) had been reported to be increased in colorectal cancer (CRC), but its effects on prognosis were still unclear.28975982
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLong non-coding RNA Loc344887 is a potential prognostic biomarker in non-small cell lung cancer.28975987
Non-Small Cell Lung CarcinomaEpigenetic AlterationsLong non-coding RNA NmrA-like family domain containing 1 pseudogene (Loc344887) has been shown to be aberrantly expressed in non-small cell lung cancer (NSCLC).28975987
Primary malignant neoplasmEpigenetic AlterationsH19, a maternally expressed imprinted gene transcribing a long noncoding RNA, has previously been reported to be involved in tumorigenesis and cancer progression.28975993
Leukemia, Myelocytic, AcuteEpigenetic AlterationsBACKGROUND MicroRNAs (miRNAs) play an important role in the development and progression of acute myeloid leukemia (AML).28978904
Liver carcinomaEpigenetic AlterationsPlasma DNA methylation marker and hepatocellular carcinoma risk prediction model for the general population.28981677
Prostate Cancer PathwayEpigenetic AlterationsFor this purpose, RNA was extracted from urinary exosomes from 20 prostate cancer patients and 9 healthy males and the microRNAs were analyzed by next generation sequencing.28982366
Prostate Cancer PathwayEpigenetic AlterationsInterestingly, 5 microRNAs - miR-196a-5p, miR-34a-5p, miR-143-3p, miR-501-3p and miR-92a-1-5p - were significantly downregulated in exosomes from prostate cancer patients.28982366
Prostate Cancer PathwayEpigenetic AlterationsThese results suggest that specific microRNAs in urinary exosomes might serve as non-invasive biomarkers for prostate cancer.28982366
Hollings Cancer CenterEpigenetic AlterationsOn the other hand, miR-223 has been identified as one of the most down-regulated miRNAs in HCC, and its expression was shown to be negatively correlated with STMN1 expression.28982915
Glioblastoma Multiforme PathwayEpigenetic AlterationsCISD2 promotes the proliferation of glioma cells via suppressing beclin-1-mediated autophagy and is targeted by microRNA-449a.28983596
Stomach CarcinomaEpigenetic AlterationsA serum exosomal microRNA panel as a potential biomarker test for gastric cancer.28986250
Primary malignant neoplasmEpigenetic AlterationsBoth normal and cancer cells can generate and secrete exosomes, which are nanosized membrane vesicles that can transport microRNAs and proteins.28986250
Stomach CarcinomaEpigenetic AlterationsThe findings from several studies have suggested that circulating miRNAs are imbalanced with the genesis of gastric cancer (GC).28986250
Hepatobiliary DisorderEpigenetic AlterationsMicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease.28987423
Rheumatoid ArthritisEpigenetic AlterationsMicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3.28987940
Rheumatoid Arthritis, Right armEpigenetic AlterationsRheumatoid arthritis-fibroblast-like synoviocytes (RA-FLS) with aberrant expression of microRNA (miRNA) have been reported to be involved in the initiation, progression, and perpetuation of rheumatoid arthritis (RA).28987940
Clinical CoordinatorEpigenetic AlterationsmiRNA expression in CRC specimens and cell lines was confirmed using qPCR analysis.28990086
Clinical CoordinatorEpigenetic AlterationsRNA-seq data revealed miR-1914 as the most prominent miRNA in CRC specimens.28990086
Renal Cell Carcinoma PathwayEpigenetic AlterationsMicroRNA-24-2 is associated with cell proliferation, invasion, migration and apoptosis in renal cell carcinoma.28990105
Acute pulmonary embolismEpigenetic AlterationsDiagnostic value of circulating microRNA-27a/b in patients with acute pulmonary embolism.28990745
RetinoblastomaEpigenetic AlterationsHistone H3 lysine-9 (H3K9) methylation is essential for retinoblastoma protein (RB)-mediated heterochromatin formation, epigenetic silencing of S-phase genes and permanent cell cycle arrest or cellular senescence.28991226
Breast Carcinoma, NeoplasmsEpigenetic AlterationsFour oncogenic microRNAs (miR-155, miR-19a, miR-181b, and miR-24) and one tumor suppressor microRNA (let-7a) were shown to differentiate between high- and low-risk early breast cancer (EBC) and reflect the surgical tumor removal and adjuvant therapy.28994735
Breast Carcinoma, Best Case Imputation TechniqueEpigenetic AlterationsOncogenic microRNAs (oncomiRs) accumulate in serum due to their increased stability and thus serve as biomarkers in breast cancer (BC) pathogenesis.28994735
Breast Carcinoma, MetastasisEpigenetic AlterationsMicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1.29016617
NeoplasmsEpigenetic AlterationsIn the last years, microRNAs were screened as new tumor markers for their potential diagnostic and therapeutic relevance.29017393
Prostate Cancer Pathway, histone modificationEpigenetic AlterationsKLF4-binding and histone-modifications were analyzed by ChIP-qPCR in prostate cancer cell lines exhibiting differentially methylated IGF2-DMR0 (LNCaP hypomethylated and DU145 hypermethylated).29017567
Prostate Cancer PathwayEpigenetic AlterationsImpairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4.29017567
Liver carcinomaEpigenetic AlterationsHepatocellular carcinoma harbors numerous genomic and epigenomic aberrations of DNA copy numbers and DNA methylation.29018224
Liver carcinomaEpigenetic AlterationsHere, we profile DNA copy numbers, DNA methylation, and messenger RNA expression levels from 64 cases of hepatocellular carcinoma specimens.29018224
Malignant NeoplasmsEpigenetic AlterationsThere is an increasing body of evidence which highlights the critical functions of long non-coding RNAs in the carcinogenicity mechanism of a variety of cancers.29022495
Leukemia, Myelocytic, AcuteEpigenetic AlterationsDNA methyltransferase 3A (DNMT3A) catalyzes de novo DNA methylation and plays important roles in the pathogenesis of acute myeloid leukemia.29024628
Primary malignant neoplasmEpigenetic AlterationsInhibition of MicroRNA-21-5p Promotes the Radiation Sensitivity of Non-Small Cell Lung Cancer Through HMSH2.29024929
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-373 Inhibits Cell Proliferation and Invasion via Targeting BRF2 in Human Non-small Cell Lung Cancer A549 Cell Line.29025258
Papillary thyroid carcinomaEpigenetic AlterationsRoles of microRNA let-7b in papillary thyroid carcinoma by regulating HMGA2.29025376
NeoplasmsEpigenetic AlterationsMicroRNAs have been demonstrated to be abnormally expressed in tumors and associated with the development of the tumors.29025376
Primary malignant neoplasmEpigenetic AlterationsSingle nucleotide polymorphisms at microRNA-binding sites contribute to cancer susceptibility and progression by affecting the messenger RNA (mRNA) function of target genes.29029037
Cardiovascular DiseasesEpigenetic AlterationsCumulative evidence shows that long noncoding RNAs among noncoding RNAs play important roles in cardiovascular diseases.29030044
Acute myocardial infarctionEpigenetic AlterationsPlatelet microRNA for predicting acute myocardial infarction.29030746
Tongue DiseasesEpigenetic AlterationsCorrelation of altered expression of a long non-coding RNA, NEAT1, in peripheral blood mononuclear cells with dengue disease progression.29031635
Tongue DiseasesEpigenetic AlterationsThe association of long non-coding RNAs (lncRNAs) with dengue disease progression is currently unknown.29031635
Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented.29034803
Malignant NeoplasmsEpigenetic AlterationsPrevious studies had demonstrated that ANGPTL4 is highly expressed in some cancers, but downregulated, by DNA methylation, in others.29035390
Carcinoma, Transitional Cell, NeoplasmsEpigenetic AlterationsEpigenetic silencing of the dual-role signal mediator, ANGPTL4 in tumor tissues and its overexpression in the urothelial carcinoma microenvironment.29035390
Carcinoma, Transitional Cell, Ulcerative Colitis, CarcinogenesisEpigenetic AlterationsUrothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs).29035390
NeoplasmsEpigenetic AlterationsOncogenic microRNAs (miRs) are stable epigenetic inhibitors often deregulated in the tumour and detectable as biomarkers in non-cellular fractions of peripheral blood.29036928
TSPYL2 wt AlleleEpigenetic AlterationsWe herein asked whether these microRNAs can be used as plasma biomarkers for clinical CTCL monitoring.29036928
Primary malignant neoplasmEpigenetic AlterationsNo DNA methylation could be found in the selected CpG islands in two types of cancer cell lines by bisulfite sequencing.29037838
Carcinoma of lung, Colorectal Cancer PathwayEpigenetic AlterationsExpression and epigenetic regulation of cystatin B in lung cancer and colorectal cancer.29037838
ovarian neoplasmEpigenetic AlterationsMicroRNA-455 inhibits cell proliferation and invasion of epithelial ovarian cancer by directly targeting Notch1.29039517
Breast Cancer CellEpigenetic AlterationsFor instance, microRNA-455 (miR-455) is abnormally expressed in various types of human cancer.29039517
Stomach CarcinomaEpigenetic AlterationsLong noncoding RNAs (lncRNAs) serve important functions in many crucial biological processes; however, the effects of lncRNAs in early gastric cancer (EGC) are not entirely clear.29039538
Malignant Neoplasms, Metastasis, NeoplasmsEpigenetic AlterationsA growing body of evidence suggests that microRNA-363 (miR-363) plays crucial roles in tumor progression, development and metastasis, and confer resistance to chemotherapeutic drugs in several types of cancers.29039555
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1-mediated PTEN/AKT signalling pathway.29039575
Primary malignant neoplasmEpigenetic AlterationsDysregulated microRNAs (miRNAs) have potential regulatory roles in the development and progression of various cancer types.29039575
Clinical CoordinatorEpigenetic AlterationsTherefore, the investigation of the miRNAs involved in CRC formation and progression may lead to the development of highly effective therapeutic strategies for CRC.29039575
Acute myocardial infarction, NCI CTEP SDC Neuroendocrine Cancer Sub-Category Terminology, Chronic Lymphocytic LeukemiaEpigenetic AlterationsLong non-coding RNA MIAT has been established as a key player in the regulation of various biological and pathological processes including chronic lymphocytic leukemias, acute myocardial infarction and neuroendocrine prostate cancer.29039602
NeoplasmsEpigenetic AlterationsWe conclude that epigenetic downregulation of tumor suppressor KIBRA may involve impaired SP1 binding to functional methylation-sensitive KIBRA promoter elements as observed in human kidney clear cell carcinoma.29046731
NeoplasmsEpigenetic AlterationsUsing matched gene expression and DNA methylation data in EAC from TCGA and other publically available data, we also find that advanced methylomic drift is correlated with significant transcriptional repression of ~ 200 genes in important regulatory and developmental pathways, including several checkpoint and tumor suppressor-like genes.29046735
Barrett EsophagusEpigenetic AlterationsIdentification of a key role of widespread epigenetic drift in Barretts esophagus and esophageal adenocarcinoma.29046735
CarcinogenesisEpigenetic AlterationsHowever, the evolving patterns, functional consequences, and dynamics of epigenetic drift during carcinogenesis remain largely unexplored.29046735
Barrett Esophagus, Adenocarcinoma Of Esophagus, Primary malignant neoplasmEpigenetic AlterationsHere we analyze the evolution of epigenetic drift patterns during progression from normal squamous esophagus tissue to Barretts esophagus (BE) to esophageal adenocarcinoma (EAC) using 173 tissue samples from 100 (nonfamilial) BE patients, along with publically available datasets including The Cancer Genome Atlas (TCGA).29046735
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis.29048575
Clinical CoordinatorEpigenetic AlterationsWe provide the first evidence that variations in potential miRNA-binding target sites in the 3 UTR of PARP1 gene may modulate CRC risk and prognosis after therapy.29048575
Clinical CoordinatorEpigenetic AlterationsSimilarly, aberrant function and/or altered expression of microRNAs (miRNAs) often occur in CRC.29048575
Malignant Neoplasms, Carcinoma of lungEpigenetic AlterationsAltered microRNA expression has been found to be a common feature of several cancers, including lung carcinomas.29048613
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1.29048619
Carcinogenesis, NeoplasmsEpigenetic AlterationsAccumulating evidence has demonstrated that aberrant miRNAs were involved in carcinogenesis and tumor progression by regulating oncogenes or tumor suppressor expression.29048619
Clinical Coordinator, NeoplasmsEpigenetic AlterationsTumour progression and development in CRC is a multi-step process involving a large number of genetic and epigenetic alterations.29048669
Colorectal Cancer PathwayEpigenetic AlterationsMicroRNA-337 inhibits colorectal cancer progression by directly targeting KRAS and suppressing the AKT and ERK pathways.29048669
Primary malignant neoplasmEpigenetic AlterationsMicroRNA-337 (miR-337) has been reported to be downregulated in several cancer types.29048669
Clinical CoordinatorEpigenetic AlterationsPrevious studies indicated that abnormally expressed microRNAs play critical roles in CRC through regulation of oncogenic and tumour-suppressor genes.29048669
Clinical CoordinatorEpigenetic AlterationsHence, determination of the function of microRNAs may provide novel therapeutic targets for CRC diagnosis and treatments.29048669
Stomach Carcinoma, MetastasisEpigenetic AlterationsMicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1.29048674
Stomach CarcinomaEpigenetic AlterationsMicroRNAs (miRNAs) are a group of critical players in gastric cancer (GC).29048674
Malignant neoplasm of urinary bladder, Malignant NeoplasmsEpigenetic AlterationsMicroRNA-154 as a prognostic factor in bladder cancer inhibits cellular malignancy by targeting RSF1 and RUNX2.29048677
Breast Cancer Cell, MetastasisEpigenetic AlterationsRecent studies have demonstrated that microRNA-154 (miR-154) is involved in tumorigenesis, progression, invasion and metastasis in several types of human cancer.29048677
Glioblastoma Multiforme PathwayEpigenetic AlterationsLong non-coding RNA PAR5 inhibits the proliferation and progression of glioma through interaction with EZH2.29048683
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsEmerging evidence suggests that long non-coding RNAs (lncRNAs) may be involved in modulating various aspects of tumor biology and serve as potential therapeutic targets as well as novel biomarkers in the treatment of glioma.29048683
Weight decreasedEpigenetic AlterationsWe also generated a potential epigenetic predictor of weight loss using baseline DNA methylation at 5 CpG sites.29049890
Autoimmune stateEpigenetic AlterationsThe potential future use of L1 ORF2-reverse transcriptase inhibitors in autoimmunity supports further investigation of L1 epigenetic regulation by APOBEC3 enzymes.29057505
Gallbladder Carcinoma, MetastasisEpigenetic AlterationsPrognostic significance of long non-coding RNA MALAT1 for predicting the recurrence and metastasis of gallbladder cancer and its effect on cell proliferation, migration, invasion, and apoptosis.29058818
Stomach CarcinomaEpigenetic AlterationsNumerous studies have proved that microRNAs (miRNAs) play crucial roles in the tumorigenesis and progression of gastric cancer (GC).29060930
Metastasis, Liver carcinomaEpigenetic AlterationsMicroRNA-30a suppresses autophagy-mediated anoikis resistance and metastasis in hepatocellular carcinoma.29061507
Liver carcinomaEpigenetic AlterationsMiRNA-30a (miR-30a) was previously reported as one of metastatic hepatocellular carcinoma (HCC)-related microRNAs.29061507
Cardiac complicationEpigenetic AlterationsMicroRNA 499 gene expression in patients on hemodialysis with cardiovascular complications.29064177
Kidney Failure, Chronic, Cardiac complicationEpigenetic AlterationsIn conclusion, miRNA 499 levels are elevated in patients with ESRD with cardiovascular complications.29064177
Secondary malignant neoplasm of liver, NeoplasmsEpigenetic AlterationsCombinatory target prediction identified tenascin C as a predicted target of miR-198, one of the top 10 miRNAs downregulated in tumour stroma of CRCs with synchronous liver metastasis.29065427
Clinical Coordinator, Secondary malignant neoplasm of liverEpigenetic AlterationsAlterations of miRNAs in CRC stroma appear to form a metastasis-permissive environment that can elevate tenascin C to promote liver metastasis.29065427
Colorectal Cancer Pathway, NeoplasmsEpigenetic AlterationsMicroRNA-329 serves a tumor suppressive role in colorectal cancer by directly targeting transforming growth factor beta-1.29067459
Clinical Coordinator, Primary malignant neoplasmEpigenetic AlterationsIncreasing studies have demonstrated that the deregulation of microRNAs (miRNAs or miRs) is associated with the occurrence and development of multiple types of human cancer, including CRC.29067459
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsWe examined how dysregulated gene expression is associated with miRNA expression in this pathway in colorectal cancer (CRC).29068474
Colorectal Cancer PathwayEpigenetic AlterationsThe PI3K/AKT signaling pathway: Associations of miRNAs with dysregulated gene expression in colorectal cancer.29068474
Left Ventricular Hypertrophy, Hypertensive (finding)Epigenetic AlterationsMicroRNA profiling identifies miR-7-5p and miR-26b-5p as differentially expressed in hypertensive patients with left ventricular hypertrophy.29069223
Left Ventricular Hypertrophy, Hypertensive diseaseEpigenetic AlterationsWe employed miRNA PCR array to screen serum miRNAs profiles of patients with LVH, essential hypertension and healthy subjects.29069223
Cardiovascular DiseasesEpigenetic AlterationsRecent evidence suggests that cell-derived circulating miRNAs may serve as biomarkers of cardiovascular diseases.29069223
Left Ventricular HypertrophyEpigenetic AlterationsWe identified 75 differentially expressed miRNAs, including 49 upregulated miRNAs and 26 downregulated miRNAs between LVH and control patients.29069223
Renal Cell Carcinoma PathwayEpigenetic AlterationsMicroRNA-30a-5p Inhibits the Growth of Renal Cell Carcinoma by Modulating GRP78 Expression.29073630
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsMiR-30a-5p, a member of the microRNA-30 family (miR-30), is known to function as a tumor suppressor in several different cancers.29073630
Malignant NeoplasmsEpigenetic AlterationsExosomal miRNAs that play an important role in cell-cell communication have attracted major attention as potential diagnostic and prognostic biomarkers for various cancers.29076027
cervical cancerEpigenetic AlterationsRegulation of miRNA gene expression by DNA promoter methylation may represent a key mechanism to drive cervical cancer progression.29077234
CarcinogenesisEpigenetic AlterationsTaken together, we have identified deregulation of miRNAs by aberrant DNA promoter methylation, leading to its transcriptional silencing during cervical carcinogenesis, which can be potential targets for diagnosis and therapy.29077234
Primary malignant neoplasmEpigenetic AlterationsDysregulated miRNA-223 expression has been implicated in a wide range of cancer subtypes.29079174
Non-Small Cell Lung CarcinomaEpigenetic AlterationsCirculating long non-coding RNA AFAP1-AS1 is a potential diagnostic biomarker for non-small cell lung cancer.29080690
Clinical CoordinatorEpigenetic AlterationsRecently, data supported that DNA methylation have a role in CRC pathogenesis.29080834
Stomach Carcinoma, MetastasisEpigenetic AlterationsEnhanced expression of the long non-coding RNA SNHG16 contributes to gastric cancer progression and metastasis.29081409
Laryngeal Squamous Cell Carcinoma, Primary malignant neoplasmEpigenetic AlterationsAltered microRNAs (miRNAs) expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC).29082244
Impaired cognitionEpigenetic AlterationsAssociation Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline.29084334
Impaired cognitionEpigenetic AlterationsBrain gene expression and DNA methylation dysregulations are implicated in the alteration of brain tissue properties associated with late-life cognitive decline above and beyond the influence of common neuropathologic conditions.29084334
Colorectal Cancer PathwayEpigenetic AlterationsmicroRNAs are small non-protein-coding RNA molecules that regulate gene expression, and have a potential epigenetic role in disease progression and survival of colorectal cancer.29084506
Colorectal Cancer PathwayEpigenetic AlterationsIdentifying factors associated with the direction and significance of microRNA tumor-normal expression differences in colorectal cancer.29084506
Colorectal Cancer PathwayEpigenetic AlterationsOur results will serve as a publicly-available resource to provide clarifying information about various factors associated with the direction and significance of tumor-normal differential expression of microRNAs in colorectal cancer.29084506
ovarian neoplasmEpigenetic AlterationsDiagnostic potential for a serum miRNA neural network for detection of ovarian cancer.29087294
ovarian neoplasmEpigenetic AlterationsAmong 454 patients with various diagnoses, the miRNA neural network had 100% specificity for ovarian cancer.29087294
ovarian neoplasmEpigenetic AlterationsThese data suggest circulating miRNAs have potential to develop a non-invasive diagnostic test for ovarian cancer.29087294
Malignant NeoplasmsEpigenetic AlterationsSubunits of the SWI/SNF chromatin remodeling complex are frequently mutated in human cancers leading to epigenetic dependencies that are therapeutically targetable.29087303
AMD1 wt AlleleEpigenetic AlterationsHowever, the role of long noncoding RNAs (lncRNAs) in the development and progression of early AMD is unclear.29089757
Breast Carcinoma, Carcinogenesis, MetastasisEpigenetic AlterationsPrevious studies have indicated that large intergenic non-coding RNA regulator of reprogramming (lincRNA-ROR) plays an important role in regulating tumor carcinogenesis and metastasis; however, whether circulating lincRNA-ROR could function as a potential biomarker for breast cancer (BC) diagnosis and monitoring is unknown.29090518
Stomach Carcinoma, EIF5A2 gene, MetastasisEpigenetic AlterationsMicroRNA-599 inhibits metastasis and epithelial-mesenchymal transition via targeting EIF5A2 in gastric cancer.29091897
Stomach CarcinomaEpigenetic AlterationsThe reliable truth that exceptional miRNAs contribute to gastric cancer (GC) development and progression had been testified by researchers.29091897
cervical cancerEpigenetic AlterationsMicroRNA-150 promotes cell proliferation, migration, and invasion of cervical cancer through targeting PDCD4.29091902
Clinical CoordinatorEpigenetic AlterationsCRC develops through combinations of genetic and epigenetic changes.29094309
Chronic Kidney Diseases, Fibrosis AssessmentEpigenetic AlterationsOf 19 CpG sites significantly associated (P < 1e-07) with eGFR/CKD and replicated, five also associate with renal fibrosis in biopsies from CKD patients and show concordant DNA methylation changes in kidney cortex.29097680
Colorectal Cancer PathwayEpigenetic AlterationsAnalyzing epigenetic control of galectin expression indicates silencing of galectin-12 by promoter methylation in colorectal cancer.29098769
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsWe therefore analyzed epigenetic mechanisms for control of galectin expression in 9 colorectal cancer (CRC) cell lines.29098769
Transcriptional Regulator ATRX, Human, Malignant Neoplasms, Sarcoma - category (morphologic abnormality), Sarcoma, synovial sarcomaEpigenetic AlterationsAlong with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors.29100075
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology, Leukemia, Myelocytic, AcuteEpigenetic AlterationsDICER1 gene and miRNA dysregulation in mesenchymal stem cells of patients with myelodysplastic syndrome and acute myeloblastic leukemia.29102598
SF3B1 wt Allele, Leukemia, Myelocytic, AcuteEpigenetic AlterationsDICER1 gene expression was lower in MSC from MDS and AML patients than HC and some differentially expressed miRNAs indicated the potential involvement of DICER1 in the pathogenesis of MDS and AML.29102598
SF3B1 wt Allele, MIR30A wt Allele, Leukemia, Myelocytic, AcuteEpigenetic AlterationsqRT-PCR confirmation revealed down-regulated miRNAs (hsa-miR-30d-5p, hsa-miR-222-3p and hsa-miR-30a-3p in MDS; hsa-miR-1275, hsa-miR-4725-5p and hsa-miR-143-3p in AML) and over-expressed miRNAs (hsa-miR-4462 in MDS; hsa-miR-134-5p and hsa-miR-874-3p in AML) in MDS and AML.29102598
Primary malignant neoplasmEpigenetic AlterationsWe tested the DNA histograms, Cyclin D1 (CCND1) protein expression and CCND1 promoter DNA methylation in 40 pathologically confirmed specimens from As-BD patients to correlate with individuals invasive cancer occurrence in the 5-year follow-up.29103775
Renal Cell Carcinoma PathwayEpigenetic AlterationsMicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma.29104726
Prostate Cancer PathwayEpigenetic AlterationsPrevious studies suggest circulating, blood-based microRNAs (miRNAs) may serve as minimally invasive prostate cancer biomarkers, however there is limited data from prospective clinical trials.29105802
Medullary carcinoma of thyroidEpigenetic AlterationsMicroRNA-21 and long non-coding RNA MALAT1 are overexpressed markers in medullary thyroid carcinoma.29107050
Stomach CarcinomaEpigenetic AlterationsLong noncoding RNA LINC00675 enhances phosphorylation of vimentin on Ser83 to suppress gastric cancer progression.29107103
Stomach Carcinoma, Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (lncRNAs) play a crucial role in cancer development, but few lncRNAs have been functionally characterized in gastric cancer (GC).29107103
Primary malignant neoplasmEpigenetic AlterationsDNA methylation is an important epigenetic modification as a hallmark in cancer.29109788
Primary malignant neoplasmEpigenetic AlterationsRecently, long non-coding RNAs (lncRNAs) have been identified as new regulatory factors in human cancer cells.29110645
NeoplasmsEpigenetic AlterationsFurthermore, microRNA-93 (miR-93) and Musashi-1 mediated the tumor suppression of LOCCS knockdown.29110645
Malignant tumor of colonEpigenetic AlterationsThis comprehensive analysis of LOCCS in colon CSCs provides insight for elucidating important roles of the lncRNA-microRNA functional network in human colon cancer.29110645
Metastasis, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are small non-coding RNAs of approximately nucleotides that regulate several aspects of tumors pathogenesis, including migration, invasion, metastasis and epithelial-mesenchymal transition.29111166
Inflammatory, Mesothelioma, Primary malignant neoplasmEpigenetic AlterationsWe show that hypermethylation of p16/Ink4a and p19/Arf in CNT- and asbestos-induced inflammatory lesions precedes mesothelioma; this results in silencing of Cdkn2a (Ink4a/Arf) and loss of p16 and p19 protein, consistent with epigenetic alterations playing a gatekeeper role in cancer.29112861
Glioblastoma Multiforme PathwayEpigenetic AlterationsSuppression of microRNA-130b inhibits glioma cell proliferation and invasion, and induces apoptosis by PTEN/AKT signaling.29115407
Glioblastoma Multiforme PathwayEpigenetic AlterationsThe close association between the abnormal expression or mutation of microRNA (miRNA) and the tumorigenesis, progression and staging in glioma have been demonstrated previously.29115407
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsHowever, the expression pattern and specific role of microRNA-130b (miR-130b) in the tumor occurrence and progression of glioma are unclear.29115407
Pancreatic carcinoma, Primary malignant neoplasmEpigenetic AlterationsPrognostic microRNAs and their potential molecular mechanism in pancreatic cancer: A study based on The Cancer Genome Atlas and bioinformatics investigation.29115476
cervical cancer, MetastasisEpigenetic AlterationsmicroRNA-211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1.29115509
CarcinogenesisEpigenetic AlterationsAn increasing number of studies have reported that microRNAs (miRNAs) have important roles in cervical cancer carcinogenesis and progression through regulation of various critical protein-coding genes.29115509
Multiple System AtrophyEpigenetic AlterationsSerum microRNA expression profiling in patients with multiple system atrophy.29115515
Parkinson Disease, "Alzheimers Disease", Neurodegenerative Disorders, Amyotrophic Lateral SclerosisEpigenetic AlterationsIt has been reported that dysregulation of microRNA (miRNA/miR) serves an important role in neurodegenerative disorders including Alzheimers disease, Parkinsons disease and amyotrophic lateral sclerosis.29115515
Malignant NeoplasmsEpigenetic AlterationsHOX transcript antisense RNA (HOTAIR), a newly discovered long noncoding RNA (lncRNA), has been reported to be a poor prognostic marker in many types of cancers.29115524
melanomaEpigenetic AlterationsMicroRNA-326 inhibits melanoma progression by targeting KRAS and suppressing the AKT and ERK signalling pathways.29115540
Malignant Neoplasms, melanomaEpigenetic AlterationsAn increasing number of studies have reported that microRNA (miRNA) dysregulation is frequently observed in various types of human cancers, including melanoma.29115540
NeoplasmsEpigenetic AlterationsRecently, miRNA-326 (miR-326) has been reported to be differentially expressed in various types of tissues and play important roles in tumourigenesis and tumour development.29115540
melanomaEpigenetic AlterationsAbnormally expressed miRNAs play an important role in melanoma formation and progression by serving as potential biomarkers and therapeutic targets.29115540
Intracranial AneurysmEpigenetic AlterationsIdentification of key genes, transcription factors and microRNAs involved in intracranial aneurysm.29115560
SeizuresEpigenetic AlterationsDownregulation of microRNA-155 by preoperative administration of VPA may prevent postoperative seizure by upregulating the expression of SCN1A.29115566
CO-methylating acetyl-CoA synthase activityEpigenetic AlterationsThe data identified an ACS-specific DNA methylation profile with a large number of novel DM CpG sites, some of which may serve as candidate markers for the early diagnosis of ACS.29115576
Glioblastoma Multiforme PathwayEpigenetic AlterationsRole of the microRNA 181 family in glioma development.29115595
NeoplasmsEpigenetic AlterationsRecent evidence indicates that miRNAs have roles as tumor suppressors and oncogenes.29115595
NeoplasmsEpigenetic AlterationsmicroRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer.29115941
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs have recently emerged as powerful regulators of cancer processes and become a promising target in cancer therapy.29116653
Stomach CarcinomaEpigenetic AlterationsAssociations of Functional MicroRNA Binding Site Polymorphisms in IL23/Th17 Inflammatory Pathway Genes with Gastric Cancer Risk.29118466
Stomach CarcinomaEpigenetic AlterationsMicroRNA- (miRNA-) binding site single-nucleotide polymorphisms (SNPs) of inflammatory genes may alter gastric cancer (GC) susceptibility.29118466
Primary malignant neoplasmEpigenetic AlterationsCirculating cell-free miRNAs have emerged as promising minimally-invasive biomarkers for early detection, prognosis and monitoring of cancer.29121858
Neurodegenerative DisordersEpigenetic AlterationsCirculating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases.29121998
Antilymphocyte Serum, Parkinson Disease, Amyotrophic Lateral Sclerosis, Admitting diagnosis, palladium, "Alzheimers Disease", Frontotemporal dementiaEpigenetic AlterationsWe describe the assessment of circulating brain-enriched microRNAs as potential biomarkers for Alzheimers disease (AD), frontotemporal dementia (FTD), Parkinsons disease (PD), and amyotrophic lateral sclerosis (ALS).29121998
Rheumatoid Arthritis, Right armEpigenetic AlterationsEpigenetic mechanisms can integrate gene-environment interactions that mediate disease transition from preclinical to clinically overt rheumatoid arthritis (RA).29126434
Right armEpigenetic AlterationsWhole blood expression profiling identified significantly differential miRNA expression in patients with RA (13 miRNAs) and FDRs (10 miRNAs) compared with HCs.29126434
Right armEpigenetic AlterationsWe highlight systematically altered circulating miRNA expression in at-risk FDRs prior to RA onset, a profile they shared with patients with RA.29126434
Squamous cell carcinoma of esophagusEpigenetic AlterationsUp-regulated miR-548k promotes esophageal squamous cell carcinoma progression via targeting long noncoding RNA-LET.29126868
Malignant NeoplasmsEpigenetic AlterationsDysregulated noncoding RNAs have been observed in diverse cancers.29126868
DiseaseEpigenetic AlterationsLong noncoding RNAs (lncRNAs) represent a novel class of noncoding RNAs that are involved in a variety of biological processes and human diseases.29129807
MIR31HG gene, Primary malignant neoplasmEpigenetic AlterationsLong non-coding RNA Loc554202 (lncRNA Loc554202) has been reported to be involved in the development of several types of cancer.29129878
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsValid evidence has demonstrated that microRNAs have critical functions in cancer genesis and tumor progression.29130108
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-329 inhibits cell proliferation and tumor growth while facilitates apoptosis via negative regulation of KDM1A in gastric cancer.29130516
Stomach CarcinomaEpigenetic AlterationsAltered expression of microRNA (miRNA) is strongly implicated in gastric cancer (GC).29130516
GastritisEpigenetic AlterationsAs opposed to adjacent tissues and gastritis tissues, miRNA-329 was highly expressed and KDM1A was low expressed in GC tissues.29130516
Stomach CarcinomaEpigenetic AlterationsForced expression of miRNA-329 in gastric cancer cells significantly promotes their capacity of apoptosis but reduces proliferation, migration, and invasion.29130516
NeoplasmsEpigenetic AlterationsIn a nude mouse subcutaneous tumor system, in vivo tumor growth of BGC-823 was significantly inhibited after treatment of miRNA-329 mimics or siRNA against KDM1A.29130516
NeoplasmsEpigenetic AlterationsWe conclude that miRNA-329 functions as a tumor suppressor in GC, which could be achieved via transcriptional suppression of KDM1A.29130516
Coronary Artery DiseaseEpigenetic AlterationsEffects of MicroRNA-499 On the Inflammatory Damage of Endothelial Cells During Coronary Artery Disease Via the Targeting of PDCD4 Through the NF-Kb/TNF-a Signaling Pathway.29131009
Malignant neoplasm of kidneyEpigenetic AlterationsMicroRNA-21 functions as an oncogene and promotes cell proliferation and invasion via TIMP3 in renal cancer.29131259
Malignant Neoplasms, Refractory Cytopenia of ChildhoodEpigenetic AlterationsMore and more evidence identified microRNAs function as positive or negative regulatory factors in many cancers, but the role of miR-21 in RCC remains unclear.29131259
LymphomaEpigenetic AlterationsIn conclusion, we identified sets of dysregulated circulating miRNA that might serve as reliable biomarkers for relapsed lymphoma.29131834
ovarian neoplasmEpigenetic AlterationsCombining serum microRNA and CA-125 as prognostic indicators of preoperative surgical outcome in women with high-grade serous ovarian cancer.29132874
NeoplasmsEpigenetic AlterationsThis work demonstrates that hit-and-run epigenetic events can prevent senescence entry, which may facilitate tumour initiation.29133799
Colon Carcinoma, MetastasisEpigenetic AlterationsMicroRNAs and their role for T stage determination and lymph node metastasis in early colon carcinoma.29134398
Primary malignant neoplasmEpigenetic AlterationsIn recent years, several studies have proposed a diagnostic and prognostic role for miRNAs in cancer.29134398
Metastasis, NeoplasmsEpigenetic AlterationsAlthough miRNAs might not represent reliable biomarkers regarding lymph node metastasis status, they could support risk assessment in stage T1 tumors.29134398
Lupus NephritisEpigenetic AlterationsWe identified 24 circulating microRNAs with differential abundance between LN-IV and CTL groups, fourteen of these microRNAs are described for the first time to lupus nephritis (hsa-miR-589-3p, hsa-miR-1260b, hsa-miR-4511, hsa-miR-485-5p, hsa-miR-584-5p, hsa-miR-543, hsa-miR-153-3p, hsa-miR-6087, hsa-miR-3942-5p, hsa-miR-7977, hsa-miR-323b-3p, hsa-miR-4732-3p and hsa-miR-6741-3p).29136041
Autoimmune Diseases, Lupus ErythematosusEpigenetic AlterationsAltered miRNAs expression levels have been reported in human autoimmune diseases including lupus.29136041
Lupus NephritisEpigenetic AlterationsVariations in the expression pattern of peripheral blood circulating miRNAs specific for this class of lupus nephritis could be correlated with the pathophysiological status of this group of individuals.29136041
ArteriosclerosisEpigenetic AlterationsPlenty of lncRNAs and microRNAs have been identified to be critical mediators in the progression of atherosclerosis (AS).29136944
NeoplasmsEpigenetic AlterationsWe observed significant miRNA expression variations among the three tumor groups.29138809
NeoplasmsEpigenetic AlterationsThis study suggests that these miRNAs may have potential value as tumor markers and implications for further understanding the molecular basis of these tumor types.29138809
NeoplasmsEpigenetic AlterationsmicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that serve important roles in biological and pathological processes in several types of human tumors.29138826
Malignant Neoplasms, Renal Cell Carcinoma PathwayEpigenetic AlterationsmiRNA (miR)-660-5p is dysregulated in many human cancers; however, its role in renal cell carcinoma is currently unclear.29138826
Primary malignant neoplasmEpigenetic AlterationsLong noncoding RNAs (LncRNAs) have been shown to serve significant roles in the diagnosis and treatment of tongue cancer.29138845
Stomach CarcinomaEpigenetic AlterationsExpression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma.29138864
Weight decreasedEpigenetic AlterationsINSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program.29138870
Weight decreasedEpigenetic AlterationsDiet-induced weight loss is also associated with differential global DNA methylation.29138870
Weight decreasedEpigenetic AlterationsDNA methylation has been proposed as a predictive biomarker for weight loss response.29138870
Weight decreased, ObesityEpigenetic AlterationsIn conclusion, a combination of genetic and epigenetic biomarkers may be used to design personalized weight loss interventions, enabling adherence and ensuring improved outcomes for obesity treatment programs.29138870
NeoplasmsEpigenetic AlterationsThe HOX transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), plays an important role in the pathogenesis and progression of multiple tumors.29141248
NeoplasmsEpigenetic AlterationsMicroRNAs have been reported to play an important role in tumor development and progression by targeting oncogenes and tumor suppressors.29141872
Hypertensive disease, Chronic Kidney DiseasesEpigenetic AlterationsPlasma microRNA-155-5p is increased among patients with chronic kidney disease and nocturnal hypertension.29146158
Clinical CoordinatorEpigenetic AlterationsDNA methylation of the UQCRB promoter revealed that most CRC patients had high methylation levels (12/15 patients) in CRC tissues compared to non-tumor tissues.29147009
Lymphoid neoplasm, LymphomaEpigenetic AlterationsThese findings indicated that prenatal genetic or epigenetic changes influence risk of adult lymphoid neoplasms and suggest a difference in this association between aggressive and indolent lymphoma subtypes.29149251
ovarian neoplasmEpigenetic AlterationsDecoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition.29150601
Stomach Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) may function as tumor suppressor or onco-miRNAs and have critical roles in the pathogenesis of gastric cancer (GC).29152656
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-216b inhibits cell proliferation and invasion in glioma by directly targeting metadherin.29152659
Breast Cancer Cell, Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsA number of studies have indicated that the abnormal expression of specific microRNAs (miR) serves vital roles in the tumorigenesis and tumor development of human cancer, including glioma.29152659
Malignant neoplasm of liverEpigenetic AlterationsMicroRNA-137 has a suppressive role in liver cancer via targeting EZH2.29152663
Liver carcinoma, Breast Cancer Cell, Metastasis, Hollings Cancer CenterEpigenetic AlterationsA variety of microRNAs (miRs) have been demonstrated to be associated with the development and malignant progression of human cancer; however, the regulatory mechanism of miR-137 underlying hepatocellular carcinoma (HCC) growth and metastasis still remains to be fully revealed.29152663
Diabetes MellitusEpigenetic AlterationsFamily history of diabetes is associated with enhanced adipose lipolysis: Evidence for the implication of epigenetic factors.29153750
Diabetes Mellitus, LipolysisEpigenetic AlterationsMoreover, the influence on lipolysis was only observed in probands with a maternal history of diabetes, thereby supporting an epigenetic impact.29153750
NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) are tissue specific, small, non-coding RNAs regulating gene expression, which may act as extracellular messengers of biological signals derived from the cross-talk between the tumor and its surrounding microenvironment.29155727
Carcinoma of lungEpigenetic AlterationsMicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening.29155727
Primary malignant neoplasmEpigenetic AlterationsDNA Methylation of miR-7 is a Mechanism Involved in Platinum Response through MAFG Overexpression in Cancer Cells.29158814
Primary malignant neoplasmEpigenetic AlterationsMethods: We combined transcriptomic data from microRNA and mRNA under the influence of an epigenetic reactivation treatment in a panel of four paired cisplatin -sensitive and -resistant cell lines, followed by real-time expression and epigenetic validations for accurate candidate selection in 19 human cancer cell lines.29158814
ovarian neoplasmEpigenetic AlterationsConclusion: The basal methylation status of miR-7 before treatment may be a potential clinical epigenetic biomarker, predictor of the chemotherapy outcome to CDDP in ovarian cancer patients.29158814
Malignant neoplasm of ovaryEpigenetic AlterationsIn the current study, we sought to identify epigenetically regulated microRNAs as novel biomarkers of platinum resistance in lung and ovarian cancers, the ones with highest ratios of associated chemo-resistance.29158814
Malignant NeoplasmsEpigenetic AlterationsAberrant promoter DNA methylation of the cysteine dioxygenase 1 (CDO1) gene is found in various human cancers and is associated with clinical outcome.29161283
Ventricular Fibrillation, Cardiac ArrhythmiaEpigenetic AlterationsLarger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias.29162046
Primary malignant neoplasmEpigenetic AlterationsFolate metabolism is required for the production of DNA precursors and for proper DNA methylation reactions, and impaired folate metabolism has been often associated with cellular growth and cancer.29162511
Clinical Coordinator, Colorectal Cancer PathwayEpigenetic AlterationsSingle-nucleotide polymorphisms (SNPs) in the promoter region of long intergenic non-coding RNAs (lincRNAs) could play a regulatory role in its expression level and then get involved in colorectal cancer (CRC).29167551
Primary malignant neoplasmEpigenetic AlterationsThe prevalence of DNA methylation of the CpG island and shore within the promoter of the - 73C allele was much less than that of the - 73A allele in both gastric tissues and cancer cell lines.29168119
Malignant NeoplasmsEpigenetic AlterationsMicroRNAs (miRs) have been reported to play significantly roles in the initiation and progression of human cancers.29170127
Carcinoma of lungEpigenetic AlterationsIdentification of a serum microRNA expression signature for detection of lung cancer, involving miR-23b, miR-221, miR-148b and miR-423-3p.29173767
palladium, Lung diseasesEpigenetic AlterationsThe expression of serum miRNA from treatment-naive lung cancer patients (LC), benign pulmonary disease patients (PD) and healthy controls (HC) were examined by PCR array.29173767
palladium, hydrocortisoneEpigenetic AlterationsLogistic regression and receiver operating characteristics curve analyses were used to identify differentially expressed miRNA signatures that could distinguish LC from PD and HC.29173767
Liquid ChromatographyEpigenetic AlterationsThese 4-miRNA signatures (miR-23b, miR-221, miR-148b and miR-423-3p) may be considered as novel, non-invasive biomarker for LC diagnosis.29173767
Primary malignant neoplasmEpigenetic AlterationsSerum mircoRNAs (miRNAs), with their noticeable stability and unique expression pattern in patients with various diseases, are powerful novel non-invasive biomarkers for cancer detection.29173767
Carcinoma of lungEpigenetic AlterationsThe objective of this study was to identify specific serum miRNAs as potential diagnostic markers for detection of lung cancer.29173767
palladium, hydrocortisoneEpigenetic AlterationsTen miRNAs (let-7f, miR-126-3p, miR-148b, miR-151-5p, miR-199a-3p, miR-221, miR-23b, miR-26a, miR-27b, and miR-423-3p) in LC were significantly increased compared to those in PD and HC in biomarker-validation phase (P<0.05).29173767
Primary malignant neoplasmEpigenetic AlterationsBioinformatic analyses showed that predicted targets of these miRNAs might have a correlation with formation and development of cancer.29173767
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-30e-5p suppresses non-small cell lung cancer tumorigenesis by regulating USP22-mediated Sirt1/JAK/STAT3 signaling.29174979
Calcification of mitral valveEpigenetic AlterationsDownregulated MicroRNA-195 in the Bicuspid Aortic Valve Promotes Calcification of Valve Interstitial Cells via Targeting SMAD7.29176317
Liver carcinoma, NeoplasmsEpigenetic AlterationsLong Non-Coding RNA Linc-USP16 Functions As a Tumour Suppressor in Hepatocellular Carcinoma by Regulating PTEN Expression.29179215
NeoplasmsEpigenetic AlterationsRecent evidence has indicated the crucial regulatory roles of long non-coding RNAs (lncRNAs) in tumour biology.29179215
Tonsillar Squamous Cell Carcinoma, Human papilloma virus infectionEpigenetic AlterationsmiRNA-expression in tonsillar squamous cell carcinomas in relation to HPV infection and expression of the antileukoproteinase SLPI.29179866
EIPR1 geneEpigenetic AlterationsRT-q-PCR-validation of the four most differentially expressed miRNAs showed that miR-363 is expressed strongest in SLPI-negative/HPV-positive TSSC.29179866
Primary malignant neoplasmEpigenetic AlterationsThe expression of these three long noncoding RNAs was significantly higher in The Cancer Genome Atlas tumoral tissues.29182008
Non-Small Cell Lung Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNAs (miRNAs) have emerged as major regulators of tumour development and progression in non-small cell lung cancer (NSCLC).29183007
Mammary Gland Parenchyma, Primary malignant neoplasmEpigenetic AlterationsIn addition to intergroup comparisons, plasma miRNA expression levels of all groups were analyzed against RNASeq data from cancerous breast tissue via The Cancer Genome Atlas (TCGA).29183284
Breast Carcinoma, NeoplasmsEpigenetic AlterationsThe most striking findings revealed elevated tumor suppressor let-7 miRNA in luminal breast cancer patients, irrespective of subtype, and elevated miR-195 in plasma of TNBC breast cancer patients.29183284
Breast Carcinoma, NeoplasmsEpigenetic AlterationsRobust expression of tumor suppressor miRNAs let-7 and miR-195 detected in plasma of Saudi female breast cancer patients.29183284
MIRN195 microRNA, human, NeoplasmsEpigenetic AlterationsIn contrast, hsa-miR-195 and let-7 miRNAs were absent from cancerous TCGA tissue and strongly expressed in surrounding non-tumor tissue indicating that cancerous cells may selectively export tumor suppressor hsa-miR-195 and let-7 miRNAs in order to maintain oncogenesis.29183284
MIRN195 microRNA, human, Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsWhile studies have indicated that the restoration of let-7 and miR-195 may be a potential therapy for cancer, these results suggested that tumor cells may selectively export hsa-miR-195 and let-7 miRNAs thereby neutralizing their potential therapeutic effect.29183284
GlomerulonephritisEpigenetic AlterationsGenetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis.29184126
Rapidly progressive glomerulonephritisEpigenetic AlterationsHere we demonstrate that microRNA-92a (miR-92a) is enriched in podocytes of patients and mice with RPGN.29184126
ImmuneEpigenetic AlterationsWe demonstrate that miRNA induction in epithelial cells can break glomerular tolerance to immune injury.29184126
Malignant tumor of colonEpigenetic AlterationsDifferences in the expression of serum miRNAs in patients with colon cancer and healthy controls were identified using miRNA microarrays.29187262
Malignant tumor of colonEpigenetic AlterationsUsing these five miRNAs to construct a miRNA expression profile (or miRNA panel) will facilitate more effective diagnosis of colon cancer.29187262
Malignant tumor of colonEpigenetic AlterationsMicroarray hybridization revealed that 87 miRNAs were differentially expressed between the sera of patients with colon cancer and healthy controls.29187262
Disease, Primary malignant neoplasmEpigenetic AlterationsThe Mediator complex is a key regulator of gene transcription, and several studies have demonstrated altered expression of particular subunits in diverse human diseases, especially cancer.29187445
Breast CarcinomaEpigenetic AlterationsMicroRNA-588 is downregulated and may have prognostic and functional roles in human breast cancer.29187727
Breast Cancer CellEpigenetic AlterationsBACKGROUND We explored the expression pattern, prognostic potential, and functional role of microRNA-588 (miR-588) in human breast cancer (BC).29187727
Colorectal Cancer PathwayEpigenetic AlterationsThe NF-kB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression.29188362
Clinical CoordinatorEpigenetic AlterationsFocusing on the genes and their associated miRNAs within the entire signalling pathway provides a comprehensive understanding of this complex pathway as it relates to CRC and offers insight into potential therapeutic agents.29188362
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsDownregulation of microRNA-1274a induces cell apoptosis through regulation of BMPR1B in clear cell renal cell carcinoma.29192325
Conventional (Clear Cell) Renal Cell CarcinomaEpigenetic AlterationsOur previous studies of the microRNA (miRNA) expression signature in clear cell renal cell carcinoma (ccRCC) indicated that miRNA-1274a (miR-1274a) was significantly upregulated in clinical specimens, suggesting that miR-1274a may act as an oncogenic miRNA in ccRCC.29192325
Non-Small Cell Lung CarcinomaEpigenetic AlterationsComparative Transcriptome Profiling Reveals Coding and Noncoding RNA Differences in NSCLC from African Americans and European Americans.29196495
NeoplasmsEpigenetic AlterationsComparative molecular profiling used mRNA (n = 22 AAs and 19 EAs) and miRNA (n = 42 AAs and 55 EAs) expression arrays to track differences in paired fresh frozen normal tissues and lung tumor specimens from AAs and EAs.29196495
Primary malignant neoplasm, NeoplasmsEpigenetic AlterationsPathway enrichment, predicted drug response, tumor microenvironment infiltration, cancer immunotherapy antigen profiling, and miRNA target enrichment were assessed.Results: AA-enriched differential gene expression was characterized by stem cell and invasion pathways.29196495
ANOPHTHALMIA AND PULMONARY HYPOPLASIAEpigenetic AlterationsWe suggest that the intratumor histone H1.3 expression as reported herein, may serve as a new epigenetic biomarker for PDAC.29197353
Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNAs have been validated to play a crucial role in tumorigenesis of non-small cell lung cancer (NSCLC).29197876
Diabetes MellitusEpigenetic AlterationsA unique plasma microRNA profile defines type 2 diabetes progression.29200427
diabeticEpigenetic AlterationsIn conclusion, we observed the major perturbation of plasma circulating microRNA in NP pre-diabetic subjects and identified a unique microRNA profile that may become helpful in predicting diabetic development.29200427
Brugada Syndrome Ventricular Arrhythmia by ECG Finding, SCN5A geneEpigenetic AlterationsH558R, a common SCN5A polymorphism, modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters.29202755
Diffuse Large B-Cell LymphomaEpigenetic AlterationsRecently, promoter methylation of PCDH10 was found in diffuse large B-cell lymphoma (DLBCL) but not in normal lymph nodes, suggesting that its epigenetic aberrance is essential to the lymphomagenesis.29202805
Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA (lncRNA) H19 has been suggested to serve important roles in the progression of gastric cancer (GC); however, the mechanism involved is largely unknown.29207111
Breast Carcinoma, NeoplasmsEpigenetic AlterationsMicroRNA-133a acts as a tumour suppressor in breast cancer through targeting LASP1.29207145
Breast Carcinoma, NeoplasmsEpigenetic AlterationsMany microRNAs (miRs) have been demonstrated to play promoting or tumor suppressive roles in human cancers including breast cancer.29207145
cervical cancerEpigenetic AlterationsLong non-coding nuclear paraspeckle assembly transcript 1 acts as prognosis biomarker and increases cell growth and invasion in cervical cancer by sequestering microRNA-101.29207151
Chronic Lymphocytic LeukemiaEpigenetic AlterationsBoth defective DNA methylation and active DNA demethylation processes are emerging as important risk factors in chronic lymphocytic leukemia (CLL).29209431
Chronic Lymphocytic LeukemiaEpigenetic AlterationsCombining cytogenetic and epigenetic approaches in chronic lymphocytic leukemia improves prognosis prediction for patients with isolated 13q deletion.29209431
Chronic Lymphocytic LeukemiaEpigenetic AlterationsHowever, associations between 5-cytosine epigenetic markers and the most frequent chromosomal abnormalities detected in CLL remain to be established.29209431
Primary malignant neoplasmEpigenetic AlterationsIn cancer, glycolysis driving enzymes and their regulating microRNAs are one of the key focus of oncology research lately.29220380
Chronic Obstructive Airway DiseaseEpigenetic AlterationsRecent data have suggested that some miRNAs are involved in the pathogenesis of COPD.29223853
Pancreatic carcinomaEpigenetic AlterationsMicroRNA-195 Suppresses the Progression of Pancreatic Cancer by Targeting DCLK1.29224010
NeoplasmsEpigenetic AlterationsMicroRNA-195 (miR-195) plays an important role in many types of tumors.29224010
Clinical CoordinatorEpigenetic AlterationsFrequent aberrant DNA methylation is known to occur in selected genes and early during CRC development, which has emerged as a new epigenetic biomarker for early detection of CRC.29225717
Malignant tumor of colonEpigenetic AlterationsMicroRNA-transcription factor interactions and their combined effect on target gene expression in colon cancer cases.29226599
Colorectal Cancer PathwayEpigenetic AlterationsWe used known TF binding sites and validated miRNA targets to determine potential miRNA-TF-TG interactions, restricting interactions to those with a TF previously associated with altered risk of colorectal cancer death.29226599
thyroglobulinEpigenetic AlterationsAdditionally, miRNAs and TFs alter each others expression, making it difficult to ascertain the effect either one has on target gene (TG) expression.29226599
thyroglobulinEpigenetic AlterationsOur results show that TG expression is influenced by both miRNAs as well as TFs, and the influence of one regulator impacts the effect of the other on the shared TG expression.29226599
Primary malignant neoplasm, Squamous cell carcinoma of esophagusEpigenetic AlterationsOur results suggested that the miRNA machinery gene expression-associated miR-SNPs would modify cancer outcomes; in this light, XPO5 may be an important new target for ESCC therapy.29226993
Renal Cell CarcinomaEpigenetic AlterationsMicroRNA-155 (MiR-155) was found to be upregulated in renal carcinoma tissue.29228417
Carcinoma of lungEpigenetic AlterationsExpressions of microRNA-876-5p and its potential target BMP-4 were analysed in lung cancer cells and patient tissues.29229885
Carcinoma of lung, NeoplasmsEpigenetic AlterationsA xenograft tumour mouse model was established to address the roles of microRNA-876-5p and BMP-4 in lung cancer EMT in vivo.29229885
Carcinoma of lungEpigenetic AlterationsMicroRNA-876- 5p was decreased while BMP-4 was increased in lung cancer cells and tissues.29229885
Carcinoma of lung, MetastasisEpigenetic AlterationsMicroRNA-876-5p expression significantly inhibited the migration, invasion and EMT of lung cancer cells in vitro, as well as metastasis in vivo, which required BMP-4 expression.29229885
Carcinoma of lungEpigenetic AlterationsMicroRNA-876-5p suppresses EMT of lung cancer by directly down-regulating BMP-4, both of which could serve as potential therapeutic targets in the treatment of lung cancer.29229885
Squamous cell carcinoma of the head and neckEpigenetic AlterationsThe involvement of passenger strand miRNA in the regulation of HNSCC pathogenesis is a novel concept in RNA research.29233721
Primary malignant neoplasmEpigenetic AlterationsOur recent studies have revealed that both strands of pre-miRNAs, the guide strand and the passenger strand, are involved in cancer pathogenesis.29233721
Non-Small Cell Lung CarcinomaEpigenetic AlterationsmRNA and miRNA expression was determined using TaqMan assays in 110 early-stage NSCLC patients.29237428
DiseaseEpigenetic AlterationsCircular RNAs (circRNAs), which are stable and conserved non-coding RNA in mammalian cells, have been reported to be widely involved in the processes of cancer disease.29241190
Multiple Myeloma, Morular Metaplasia of the EndometriumEpigenetic AlterationsAs the promoter region of its host gene, EVL, is embedded in a CpG island, we postulated that miR-342-3p is an intronic miRNA co-regulated with its host gene by promoter DNA methylation in multiple myeloma (MM).29242101
Multiple MyelomaEpigenetic AlterationsEpigenetic silencing of EVL/miR-342 in multiple myeloma.29242101
Malignant Neoplasms, NeoplasmsEpigenetic AlterationsmiR-342-3p, localized to 14q32, is a tumor suppressor miRNA implicated in multiple cancers.29242101
Diffuse Large B-Cell LymphomaEpigenetic AlterationsTo identify biological correlates for treatment resistance, we profiled microRNAs (miRNAs) of matched primary and relapsed DLBCL by next-generation sequencing.29242506
cervical cancerEpigenetic AlterationsMiRNA-338-3p regulates cervical cancer cells proliferation by targeting MACC1 through MAPK signaling pathway.29243777
NeoplasmsEpigenetic AlterationsLong non-coding RNA CRNDE is a novel tumor promoter by modulating PI3K/AKT signal pathways in human gastric cancer.29243780
Malignant Neoplasms, Stomach CarcinomaEpigenetic AlterationsLong non-coding RNA CRNDE (CRNDE) recently emerged as a carcinogenic promoter in various cancers including gastric cancer (GC).29243780
Metastasis, Squamous cell carcinoma of esophagus, NeoplasmsEpigenetic AlterationsOur results thus suggest that LUCAT1 regulates the stability of DNMT1 and inhibits the expression of tumor suppressors through DNA methylation, leading to the formation and metastasis of ESCC.29247823
Squamous cell carcinoma of esophagusEpigenetic AlterationsThe long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.29247823
Malignant NeoplasmsEpigenetic AlterationsRecently, many long noncoding RNAs (lncRNAs) have been reported to be involved in various cancers.29247823
Head and Neck CarcinomaEpigenetic AlterationsAberrations in Wnt signaling pathway are related to the pathogenesis of head and neck carcinomas and their activation frequently results from epigenetic alterations.29254794
Oral Cavity Carcinoma, NeoplasmsEpigenetic AlterationsOur findings corroborate that DAB2 is a frequent target of epigenetic silencing in oral carcinomas and may be potentially used for tumor detection.29254794
Degenerative polyarthritisEpigenetic AlterationsWe identified a three-miRNA signature, hsa-miR-140-3p, hsa-miR-671-3p, and hsa-miR-33b-3p, in the serum of OA patients, predicted to regulate metabolic processes, which could serve as a potential biomarker for the evaluation of OA risk and progression.29255496
Degenerative polyarthritisEpigenetic AlterationsWe identified 279 differentially expressed miRNAs in the serum of OA patients compared to controls.29255496
Degenerative polyarthritisEpigenetic AlterationsqRT-PCR validation in seven selected out of the 77 miRNAs revealed 3 significantly downregulated miRNAs (hsa-miR-33b-3p, hsa-miR-671-3p, and hsa-miR-140-3p) in the serum of OA patients, which were in silico predicted to be enriched in pathways involved in metabolic processes.29255496
Glioblastoma MultiformeEpigenetic AlterationsMicroRNA-376a inhibits cell proliferation and invasion in glioblastoma multiforme by directly targeting specificity protein 1.29257212
Malignant NeoplasmsEpigenetic AlterationsmiRNA (miR)-376a is abnormally expressed in multiple human cancers; however, the expression pattern and role of miR-376a in GBM, and the underlying molecular mechanisms by which miR-376a exerts its functions remain to be elucidated.29257212
Primary malignant neoplasmEpigenetic AlterationsmicroRNAs (miRNAs) are aberrantly expressed in numerous cancer types, including GBM.29257212
MetastasisEpigenetic AlterationsAbnormally expressed miRNAs are commonly associated with malignant characteristics of GBM, including malignant growth, proliferation, apoptosis, invasion, metastasis and resistance to chemotherapy.29257212
Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miR)-455-5p has been identified as a biomarker for various types of cancer and may therefore be involved in the regulation of cancer development and progression.29257232
Primary malignant neoplasmEpigenetic AlterationsRecently, microRNAs (miRs) have been considered as novel therapeutic targets for the treatment of cancer.29257251
Metastasis, Primary malignant neoplasmEpigenetic AlterationsMicroRNA (miR)-185, which has been reported to be abnormally expressed in some types of cancer, exerts significant effects on the proliferation, apoptosis, drug resistance and metastasis of cancer cells.29257260
Intervertebral disc disorderEpigenetic AlterationsThe effects of long non-coding RNAs on the proliferation and development of IDD have attracted increasing attention.29257270
Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNA-103 suppresses glioma cell proliferation and invasion by targeting the brain-derived neurotrophic factor.29257320
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsMicroRNAs (miRNAs/miRs) are involved in tumour development of various human cancers, including glioma.29257320
Neoplasms, Glioblastoma Multiforme PathwayEpigenetic AlterationsTherefore, miRNAs may have potential tumour diagnostic, prognostic and therapeutic values in human glioma.29257320
NeoplasmsEpigenetic AlterationsMicroRNA-373 (miR-373) has been reported to be an oncogene in a number of solid human tumors.29257346
Metastasis, Adenocarcinoma of lung (disorder)Epigenetic AlterationsThe ceRNA network revealed that 10 microRNAs (miRs; including miR-16-5p and miR-214-3p), 123 long non-coding RNAs (including X-inactive specific transcript, H19 and metastasis associated lung adenocarcinoma transcript 1) and 408 circular RNAs (including ATP-binding cassette subfamily C member 1 hsa_circ_001569 and ISY1 splicing factor homolog hsa_circ_001859) may regulate the expression of FOXP3, IL-10 and CD274.29257349
Electrocardiogram: myocardial infarction (finding)Epigenetic AlterationsCirculating Long Noncoding RNA HOTAIR is an Essential Mediator of Acute Myocardial Infarction.29258067
Matrix Metalloproteinase 9, Diabetes MellitusEpigenetic AlterationsCrosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes.29261844
Diabetes MellitusEpigenetic AlterationsMMP-9 promoter has binding sites for many transcription factors, and in diabetes its promoter undergoes epigenetic modifications, including histone modifications and DNA methylation.29261844
Diabetes MellitusEpigenetic AlterationsActivation of Ezh2 in diabetes, via trimethylation of H3K27, facilitates recruitment of the enzymes responsible for regulation of DNA methylation of the MMP-9 promoter, resulting in its transcriptional activation.29261844
Diabetes MellitusEpigenetic AlterationsThus, a close crosstalk between H3K27 trimethylation and DNA methylation in diabetes plays a critical role in the maintenance of cellular epigenetic integrity of MMP-9.29261844
Primary malignant neoplasmEpigenetic AlterationsHistones undergo extensive post-translational modifications and this epigenetic regulation plays an important role in modulating transcriptional programs capable of driving cancer progression.29262808
Primary malignant neoplasmEpigenetic AlterationsAberrant circulating DNA methylation (DNAme) patterns are likely to provide a highly specific cancer signal.29268762
ovarian neoplasm, NeoplasmsEpigenetic AlterationsThe potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer.29268796
Squamous cell carcinoma of esophagusEpigenetic AlterationsTargeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC).29270239
Primary malignant neoplasmEpigenetic AlterationsDNA methylation has been implicated as a promising biomarker for precise cancer diagnosis.29270239
Squamous cell carcinoma of esophagusEpigenetic AlterationsHowever, limited DNA methylation-based biomarkers have been described in esophageal squamous cell carcinoma (ESCC).29270239
Squamous cell carcinoma of esophagus, Primary malignant neoplasmEpigenetic AlterationsA high-throughput DNA methylation dataset (100 samples) of ESCC from The Cancer Genome Atlas (TCGA) project was analyzed and validated along with another independent dataset (12 samples) from the Gene Expression Omnibus (GEO) database.29270239
Carcinoma of lungEpigenetic AlterationsBronchial biopsy specimen as a surrogate for DNA methylation analysis in inoperable lung cancer.29270240
Primary malignant neoplasmEpigenetic AlterationsMicroRNAs are small endogenous non-coding RNAs, which can frequently emerge as regulators in many cancer types.29275213
Left Ventricular HypertrophyEpigenetic AlterationsSerum MicroRNA-27b as a Screening Biomarker for Left Ventricular Hypertrophy.29276436
Squamous cell carcinoma of the head and neck, Tumor PromotersEpigenetic AlterationsHerein we report for the first time that miR-1275 could act as a tumor-promoter in SCCHN possibly by regulating its target gene via novel miRNA mechanisms.29278769
Squamous cell carcinoma of the head and neckEpigenetic AlterationsmiRNAs can play vital role in migration, invasion and proliferation in Squamous cell carcinoma of head and neck (SCCHN).29278769
Malignant Neoplasms, Primary malignant neoplasmEpigenetic AlterationsThe analysis of our original miRNA expression signatures of human cancers revealed that microRNA-150-5p (miR-150-5p) was downregulated in various types of cancer, indicating that miR-150-5p acts as an antitumor miRNA by targeting several oncogenic genes.29286099
Squamous cell carcinoma of lungEpigenetic AlterationsDownregulation of matrix metalloproteinase 14 by the antitumor miRNA, miR-150-5p, inhibits the aggressiveness of lung squamous cell carcinoma cells.29286099
Metastasis, Non-Small Cell Lung CarcinomaEpigenetic AlterationsMicroRNA-454 inhibits non-small cell lung cancer cells growth and metastasis via targeting signal transducer and activator of transcription-3.29286124
Non-Small Cell Lung CarcinomaEpigenetic AlterationsEmerging studies have suggested that microRNAs are dysregulated in NSCLC and serve important roles in NSCLC initiation and development.29286124
SF3B1 wt Allele, NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyEpigenetic AlterationsUtility of 5-Methylcytosine Immunohistochemical Staining to Assess Global DNA Methylation and Its Prognostic Impact in MDS Patients Background: DNA methylation plays a vital role in the pathogenesis of the myelodysplastic syndrome (MDS), a heterogeneous group of clonal hematopoietic stem cell (HSC) disorders.29286224
Vulval intraepithelial neoplasia, CARCINOMA OF VULVAEpigenetic AlterationsNormalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma.29299981
Vulval intraepithelial neoplasia, Squamous cell carcinoma of vulvaEpigenetic AlterationsOur work is the first report on reference microRNA selection for quantitative real-time polymerase chain reaction applications in vulvar intraepithelial neoplasia lesion and vulvar squamous cell carcinoma.29299981
Vulval intraepithelial neoplasia, Squamous cell carcinoma of vulvaEpigenetic AlterationsTo date, no suitable reference microRNAs for normalizing quantitative real-time polymerase chain reaction assays has been identified in vulvar intraepithelial neoplasia lesions and vulvar squamous cell carcinoma.29299981
Vulval intraepithelial neoplasia, Squamous cell carcinoma of vulvaEpigenetic AlterationsThe results pointed at hsa-miR-93-5p and hsa-miR-425-5p as microRNAs that retained the greatest robustness in plasma of vulvar intraepithelial neoplasia lesion and vulvar squamous cell carcinoma patients, respectively.29299981
Malignant neoplasm of larynx, NeoplasmsEpigenetic AlterationsThe secondary endpoint was to identify specific deregulated miRNAs with potential as prognostic biomarkers for tumour spread and nodal involvement, and specifically to search for a miRNA pattern pathognomonic for N+ laryngeal cancer and for N- tissues.29327732
Malignant neoplasm of larynx, Carcinoma of larynxEpigenetic AlterationsWe identified 20 miRNAs specific for laryngeal cancer and a tissue-specific miRNA signature that is predictive of lymph node metastases in laryngeal carcinoma characterised by 11 miRNAs, seven of which are overexpressed (upregulated) and four downregulated.29327732
NeoplasmsEpigenetic AlterationsThe discovery that miRNAs are frequently deregulated in tumours offers the opportunity to identify them as prognostic and diagnostic markers.29327732
Malignant Neoplasms, Aggressive behaviorEpigenetic AlterationsMicroRNAs have been shown to modulate the aggressiveness of various cancers, and have emerged as possible therapeutic agents for the management of GBM.29345288
Malignant Neoplasms, Colorectal Cancer PathwayEpigenetic AlterationsDeregulated levels of miRNA were found in many types of cancers including colorectal cancer.29355387
NeoplasmsEpigenetic AlterationsOur results showed an up-regulation of all measured miRNAs in tumor tissue compared to adjacent tissues.29355387
NeoplasmsEpigenetic AlterationsAs expected, tumors and adjacent tissues exhibited a significantly higher expression of leading miRNAs compared to passenger strand of miR-21 and miR-16.29355387
Congenital contractural arachnodactylyEpigenetic AlterationsAlthough aberrant DNA methylation in CCA has been reported by several investigators, little is known regarding the associations between them.29359783
Congenital contractural arachnodactylyEpigenetic AlterationsIn conclusion, the present study revealed the value of aberrant DNA methylation of HTATIP2 and UCHL1, which may serve as a potential predictive biomarker for CCA.29359783
Malignant neoplasm of endometriumEpigenetic AlterationsDNA methylation as mechanism of apoptotic resistance development in endometrial cancer patients.29372685
CarcinogenesisEpigenetic AlterationsAberrant DNA methylation changes result in deregulation of important apoptotic proteins during endometrial carcinogenesis and apoptosis resistance development.29372685
CarcinogenesisEpigenetic AlterationsWe observed as the first a significant difference in promoter DNA methylation status in genes: BCL2L11 (p < 0.001), CIDEB (p < 0.03) and GADD45A (p < 0.05) during endometrial carcinogenesis and BIK gene (p < 0.03) in different phases of normal menstrual cycle.29372685
Degenerative polyarthritisEpigenetic AlterationsRecent studies suggest that cytokines and microRNAs play a key role in the destruction of cartilage matrix in osteoarthritis (OA) tissues.29441883
Antilymphocyte Serum, Amyotrophic Lateral SclerosisEpigenetic AlterationsThe occurrence of mutations of TDP-43, FUS, and C9ORF72 in amyotrophic lateral sclerosis (ALS) suggests pathogenic alterations to RNA metabolism and specifically to microRNA (miRNA) biology.29458840
Antilymphocyte SerumEpigenetic AlterationsThen, we tested this set of miRNAs in the serum from sporadic ALS patients, observing a significant deregulation of hsa-miR-142-3p and hsa-miR-1249-3p.29458840
Chronic Lymphocytic LeukemiaEpigenetic AlterationsMicroRNA-155-5p Overexpression in Peripheral Blood Mononuclear Cells of Chronic Lymphocytic Leukemia Patients Is a Novel, Independent Molecular Biomarker of Poor Prognosis.29463948
InflammationEpigenetic AlterationsMicroRNA-155-5p (miR-155-5p) is a proinflammatory, oncogenic miRNA, involved in various physiological processes, including hematopoiesis, immunity, inflammation, and cell lineage differentiation.29463948
Extrahepatic CholangiocarcinomaEpigenetic AlterationsDNA Methylation Markers Improve the Sensitivity of Endoscopic Retrograde Cholangiopancreatography-Based Brushing Cytology in Extrahepatic Cholangiocarcinoma.29484968
Malignant Biliary ObstructionEpigenetic AlterationsIn conclusion, measurement of the DNA methylation status of HOXA1 and NEUROG1 genes in leftover brushed biliary cells might serve as a useful supplement in the detection of malignant biliary obstruction by increasing the sensitivity of diagnosis by routine cytology.29484968
Carcinoma, Ovarian EpithelialEpigenetic AlterationsLong non-coding RNAs (lncRNAs) have been proved to play important roles in the tumorigenesis and development of human epithelial ovarian cancer (EOC).29693889